Input: Analysis of promoter and androgen regulatory sequences required for optimal transcription of the rat androgen-binding protein gene.

androgen-binding protein


Input: In a gntR deletion mutant, the expression of a chromosomal gntT:: lacZ fusion is both high and constitutive, confirming that GntR is the negative regulator of gntT.

gntR deletion mutant

gntT

lacZ

GntR

gntT


Input: Therefore, we conclude that DnaA may contact the beta subunit of RNA polymerase during activation of the pR promoter.

DnaA

RNA polymerase

pR promoter


Input: Expression of Bcl-XL inhibited the association of Apaf-1 with caspase-9 in mammalian cells.

Bcl-XL


Input: Whole-mount in situ hybridization to early mouse embryos of 9. 5-10. 5 days indicated a complex pattern of Arp1 expression spatially overlapping with the expression of All1.


Input: Creatine kinase release after hepatic artery embolization in patients with carcinoid tumors.

Creatine kinase


Input: Our observations suggest that members of the HMG-I family play an important role in SRF-dependent transcription and that their effect is mediated primarily by a protein-protein interaction.

HMG-I family

SRF


Input: We recently characterized a single yeast hnRNP methyltransferase (HMT1).

yeast hnRNP methyltransferase


Input: We recently characterized a single yeast hnRNP methyltransferase (HMT1).

yeast hnRNP methyltransferase


Input: Recombinant HRMT1L2 protein encoded by the most common 5'-variant exhibited methyltransferase activity in vitro.

Recombinant HRMT1L2 protein


Input: The possible roles of HRMT1L1 and HRMT1L2 in human disease are currently unknown.


Input: Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2).

human arginine methyltransferases


Input: To identify nuclear regulatory factors, we have located and functionally characterized the CCR5 gene promoter.

CCR5 gene promoter


Input: The interaction between piroxicam and poloxamer was studied by x-ray diffractometry (XRD), infrared (IR) spectroscopy and differential thermal analysis (DTA) with a solid dispersion, coprecipitate, or physical mixture.


Input: The results confirm that a single base change in the branchpoint consensus sequence of an intron can cause human disease although this sequence is poorly conserved in mammals.


Input: It bound to vitamin D receptor (VDR) but not retinoic acid Xalpha receptor (RXRalpha) in the human T cell line MT2 cells.

vitamin D receptor

VDR

retinoic acid Xalpha receptor

RXRalpha


Input: Based on the current literature, the mechanisms involved in the toxicity of OA indicate three major effects: (1) inhibition of mitochondrial respiration correlated with a depletion of ATP; (2) inhibition of tRNA-synthetase accompanied by a reduced protein synthesis; and (3) enhanced lipid peroxidation.

OA

tRNA-synthetase


Input: Another stem-loop called structure III near the 3'-end of repY sequesters both the 5'-rCGCC-3' sequence and the repZ ribosome-binding site.

repY

repZ ribosome-binding site


Input: The general transcription factor IIA (TFIIA) interacts with the TATA binding protein (TBP) and promoter DNA to mediate transcription activation in vitro.

transcription factor IIA

TFIIA

TATA binding protein

TBP


Input: Localization of 67 exons on a YAC contig spanning 1. 5 Mb around the multidrug resistance gene region of human chromosome 7q21. 1.

multidrug resistance gene region


Input: Using Southern blot analysis and restriction mapping of genomic YAC (yeast artificial chromosome) and cosmid clones, we located the human RIL gene 240-260 kb telomeric to the IRF1 gene and characterized its genomic structure.

human RIL gene

IRF1 gene


Input: U73 contains C, D and D' boxes and a 12-nucleotide antisense complementarity to the 28S ribosomal RNA.

28S ribosomal RNA


Input: However, mandibular position (S-N-B and S-N-Pog) was found to be significantly more retrusive in Class II when compared with Class I subjects.


Input: Echinostomiasis is aggravated by socioeconomic factors such as poverty, malnutrition, an explosively growing free-food market, a lack of supervised food inspection, poor or insufficient sanitation, other helminthiases, and declining economic conditions.


Input: The localization of ZAP-70 to the cell cortex is, therefore, regulated by the activity of SRC-family kinases, independently of their ability to phosphorylate immunoreceptor tyrosine-based activation motifs of the TCR.

SRC-family kinases

TCR


Input: The effect of nitric oxide synthase inhibitor on reperfusion injury of the brain under hypothermic circulatory arrest.

nitric oxide synthase


Input: UDP-GlcNAc: alpha-6-D-mannoside beta-1, 2-N-acetylglucosaminyltransferase II (GnT II; EC 2. 4. 1. 143) is essential for the normal assembly of complex Asn-linked glycans.

UDP-GlcNAc

alpha-6-D-mannoside beta-1, 2-N-acetylglucosaminyltransferase II

GnT II

EC 2. 4. 1. 143


Input: Taken together, these results suggest that silymarin may exert a strong anticarcinogenic effect against PCA and that this effect is likely to involve impairment of erbB1-SHC-mediated signaling pathway, induction of CDKIs, and a resultant G1 arrest.

SHC

CDKIs


Input: In connective tissue, cell structure contributes to type I collagen expression.

type I collagen


Input: A point mutation in Galphao and Galphai1 blocks interaction with regulator of G protein signaling proteins.

Galphao

G protein


Input: Indeed, it is shown that it mediates the formation of disulfide-linked homodimers and that the formation of homo-and heterodimers are mutually excluded.


Input: N., and Fanning, E.


Input: In patients with type IA maple syrup urine disease, the E1alpha subunit is affected, resulting in the loss of E1 and branched-chain ketoacid dehydrogenase catalytic activities.

E1alpha subunit

branched-chain ketoacid dehydrogenase


Input: All patients diagnosed of H. influenza type b meningitis were less than 3 years old.


Input: Immunohistochemically, anticytokeratin 19 antibody revealed strong staining in both epithelial and sarcomatous MPM tissues.

anticytokeratin 19 antibody


Input: Combined expression of c-Jun and p65 induced vigorous transcription of IL-2 promoter-and CD28RE-driven reporter constructs in both LFA-3-and B7-1-costimulated Jurkat cells.

c-Jun

CD28RE-driven reporter constructs


Input: Liquid chromatographic method for analysis of all-rac-alpha-tocopheryl acetate and retinyl palmitate in milk-based infant formula using matrix solid-phase dispersion.


Input: The ability to maintain expression of FAS1 in nmt1-451Dino2 Delta cells suggests the existence of another transcription factor, or factors, whose expression/activity is inversely related to overall levels of cellular protein N-myristoy-lation.


Input: The identified isolates of CSF (20 of 29) were: ECHO 30 (9), ECHO 11 (7), ECHO 9 (3) and ECHO 7 (1).


Input: There was no evidence of any persistent oscillation within the ULF band.


Input: A large deletion in the CTD-binding motif blocks down-regulation but does not affect the essential function of Nrd1.

CTD-binding motif


Input: Thus, included in the KG1a EST dataset are candidates for new human genes that may play roles in hematopoietic differentiative progression and lineage commitment.


Input: Sp1 and two Sp3 isoforms were detected as the primary cellular constituents of DNA-protein complexes formed with the NF-kappaB-proximal site.

Sp3 isoforms

NF-kappaB-proximal site


Input: The second patient had received pituitary-derived growth hormone for treatment of growth hormone deficiency, secondary to a third ventricle teratoma, exised 13 yr earlier.

pituitary-derived growth hormone

growth hormone


Input: Binding affinities of different nucleotide mono-, di-and triphosphates and non-hydrolyzable analogs indicate that the beta-phosphate moiety is required for substrate binding.


Input: [Treatment of early T1 small T2N breast cancers.


Input: Malaria had diminished significantly by the early 1940s, and this paper queries whether that reduction was due to the control projects of the thirties, and, if so, whether such projects should be a model for the current developing world, where malaria is a growing problem today.


Input: Fowlpox virus encodes nonessential homologs of cellular alpha-SNAP, PC-1, and an orphan human homolog of a secreted nematode protein.

cellular alpha-SNAP


Input: Further, Ser/Thr phosphorylation of downstream molecules Akt and p70 S6 kinase was inhibited.

Akt

p70 S6 kinase


Input: Quantitative evaluation of the steady state kinetics of MEK inhibition by these compounds reveals that U0126 has approximately 100-fold higher affinity for deltaN3-S218E/S222D MEK than does PD098059.

MEK

deltaN3-S218E/S222D MEK


Input: However, little is known regarding the genomic organization and developmental expression of the caveolin gene family.

caveolin gene family


Input: Tensile bond strengths between resin composite and bovine dentin using dentin adhesive systems (Clearfil Liner Bond II: LB II; Scotchbond Multi-Purpose: MP) bonding systems showed a large scatter among students and dentists.


Input: To better understand the role of Ets proteins in Ras transformation, we have now analyzed the effects of stably expressing a variety of Ets2 constructs in Ras-transformed NIH3T3 (DT) cells.

Ets proteins

Ras

Ets2 constructs

Ras


Input: Manipulation of the checkpoint regulators involved in cell cycle arrest and apoptosis may thus provide a novel strategy to cancer therapy.


Input: The diagnostic accuracy of serum PE-1 was 0. 80, and that of amylase 0. 97.

amylase


Input: We demonstrate that Ddc1p interacts physically in vivo with Mec3p, and this interaction requires Rad17p.


Input: Deleting SNF1 repressed meiosis at the same three steps that were inhibited by glucose, suggesting that glucose blocks meiosis by inhibiting Snf1.


Input: Ligand-independent activation of platelet-derived growth factor receptor is a necessary intermediate in lysophosphatidic, acid-stimulated mitogenic activity in L cells.

platelet-derived growth factor receptor


Input: In canrenoate-treated rats, ANP infusion caused greater increases in sodium excretion (FENA from 3. 05 +/-0. 71 to 7. 21 +/-0. 45%; P < 0. 05; n = 8) than saline infusion (FENA from 4. 16 +/-1. 11 to 5. 47 +/-0. 66%; n = 6), despite the hypocapnia.

ANP


Input: Identical c-erbB3 transcripts are expressed in normal human placental tissues.

c-erbB3 transcripts


Input: Downregulation of FUS expression in BCR/ABL-expressing 32Dcl3 cells was associated with suppression of growth factor-independent colony formation, restoration of G-CSF-induced granulocytic differentiation and reduced tumorigenic potential in vivo.

FUS

BCR

ABL

G-CSF


Input: We propose a model in which Sro7 function is involved in the targeting of the myosin proteins to their intrinsic pathways.

myosin proteins


Input: In experiments with the D1 antagonist SCH 23390, buprenorphine-induced depression was consistently blocked, but facilitation was unaffected.


Input: Acute idiopathic thrombocytopenic purpura presenting a high serum level of immunoglobulin E and eosinophilia in an elderly patient.

immunoglobulin E


Input: The purpose of this article is to discuss the factors involved in the selection of antibodies, radionuclides and labeling methods in the development of radioimmunotherapy (RIT) for non-Hodgkin' s lymphoma (NHL) from a single clinical study site through multicenter trials and commercialization.


Input: Transcriptional regulation of the GluR2 gene: neural-specific expression, multiple promoters, and regulatory elements.

GluR2 gene


Input: The binding of NF-ATp, although not NF-AT4, to this enhancer also occurs along with HTLV-I-mediated infection of human peripheral blood T-cells.

NF-ATp


Input: Thus, TRAF2 initiates SAPK and p38 activation by binding two proximal protein kinases: GCK and RIP.

SAPK

GCK

RIP


Input: Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38.

Tumor necrosis factor

stress-activated protein kinase

SAPK

Jun NH2-terminal kinase

JNK


Input: The activity of the minimal promoter was found to be controlled by a combination of the activities of the transcription factors Sp1, Sp3, and NF-Y.

NF-Y


Input: Pressure ulcers.


Input: TBP can be phosphorylated in vitro by extracts of U937 cells or by bacterially expressed activated ERK2; the phosphorylation sites were mapped to ERK kinase consensus sites in the TBP amino-terminal domain.

TBP

ERK kinase consensus sites

TBP amino-terminal domain


Input: During the CR/PP diet only the HS subjects did not show the stress-induced rise in depression, decline in vigour and cortisol elevation that they showed after the PR/CP diet.


Input: Evidence for a novel MAPKKK-independent pathway controlling the stress activated Sty1/Spc1 MAP kinase in fission yeast.

MAPKKK


Input: Furthermore, we demonstrated that Galpha11 Q209L stimulated Src family kinase activity and induced tyrosine phosphorylation of several proteins in HEK-293 cells.

Galpha11 Q209L

Src family


Input: The micturition pressure was significantly decreased only after injection with BUP-4 in both normal and obstructed rats.


Input: Peroxisome proliferator-activated receptors (PPAR) modulate transcription by binding to specific peroxisome proliferator-response elements (PPRE) through heterodimerization with the 9-cis retinoic acid receptor (RXR).

Peroxisome proliferator-activated receptors

PPAR

9-cis retinoic acid receptor

RXR


Input: Molecular cloning and functional characterization of murine sphingosine kinase.

murine sphingosine kinase


Input: Our results show that, from a thermodynamical standpoint, melatonin may directly scavenge hydroxyl radicals both in vacuum and in aqueous solution.


Input: This sequence, Thr-Gly-X-X-Gly-Asp-Gly-Lys-Ile-Phe, forms part of the B-loop and is conserved in a wide variety of organisms that include bacteria, algae and archeabacteria.


Input: The only abundant viral transcript expressed during latency is the latency-related (LR) RNA.

latency-related

LR


Input: Expression of constitutively active MEK1, the kinase that activates ERKs, or overexpression of ERK2, but not JNK1, inhibited Stat3 activation.

ERKs


Input: MEKs and ERKs inhibited IL-6 activation of Stat3 harboring a mutation at serine-727, the major site for serine phosphorylation, similar to inhibition of wild-type Stat3, and inhibited Janus kinases Jak1 and Jak2 upstream of Stat3 in the Jak-STAT-signaling pathway.

MEKs

ERKs

wild-type Stat3

Janus kinases Jak1

Jak

STAT


Input: Genome plasticity in the distal tail fiber locus of the T-even bacteriophage: recombination between conserved motifs swaps adhesin specificity.

adhesin


Input: Whereas, in the single-chambered body box, PenH units (Enhanced Pause) reflect " effort of breathing. " This is measured as the pause between inspiration and expiration.


Input: This suggests that while underpredictions of pain do not hurt more, disruption on primary tasks and physiological impact are higher.


Input: Badcock and Westheimer (Spatial Vision 1 (1), 3-11, 1985) showed that a thin vertical line induces nearby zones of attraction and repulsion; this study extends those results by more closely examining the horizontal and vertical extents of the repulsion zone and by using an illusory contour to induce repulsion.


Input: desmethyltrimebutine was inactive.


Input: A 5. 0-kb transcript detected by the differential display amplicon 3G1 was found to correlate strongly with RAG1 mRNA expression in various human cell lines.

RAG1 mRNA


Input: The hBRAG gene was localized to the long arm of chromosome 10 (10q26).

hBRAG gene


Input: Genomic locus of chCTCF contains a GC-rich untranslated exon separated from seven coding exons by a long intron.

chCTCF


Input: Small GTPases of the Ypt/Rab family are involved in the regulation of vesicular transport.

Small GTPases

Ypt

Rab


Input: The GEF and GAP activities for Ypt1p localize to particulate cellular fractions.

GEF

GAP


Input: Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to noradrenaline and is selectively expressed in noradrenergic and adrenergic neurons and neuroendocrine cells.

Dopamine beta-hydroxylase

DBH


Input: Collectively, this study emphasizes a critical role of Phox2a as well as its functional synergism with other transcription factors (e. g., CREB, AP2, and Sp1) in transcriptional activation of the DBH gene.

CREB

DBH gene


Input: Sequence comparisons strongly suggest that the S27a and the ubiquitin coding sequences found in the genome of CP Rit were both derived from a bovine mRNA encoding a hybrid protein with the structure NH2-ubiquitin-S27a-COOH.

ubiquitin

ubiquitin


Input: J.


Input: There was a trend in all studies favouring PVI.


Input: This domain, although adjacent to the 5' edge of the SD sequence, does not inhibit ribosome binding as long as the single-stranded region of domain 3 is present.


Input: Previous genetic studies led to the conclusion that nitrate and nitrite induction of nasF operon expression is determined by a transcriptional antitermination mechanism.

nasF operon


Input: EGFR levels were found to be elevated 5-, 3.

EGFR


Input: Furthermore, LB1 gene mapped to chromosome 13q14, a region that has been involved as a chromosomal breakpoint in DLBL.

LB1 gene


Input: Wild-type AT1A receptors, expressed in Chinese hamster ovary cells, rapidly internalized after Ang II stimulation [t1/2 2. 3 min; maximal level of internalization (Ymax) 78. 2%], as did mutant receptors carrying single acidic substitutions (T332E, t1/2 2. 7 min, Ymax 76. 3%; S335D, t1/2 2. 4 min, Ymax 76. 7%; T336E, t1/2 2. 5 min, Ymax 78. 2%; S338D, t1/2 2. 6 min, Ymax 78. 4%).

Wild-type AT1A receptors

Ang II


Input: The activated glucocorticoid receptor forms a complex with Stat5 and enhances Stat5-mediated transcriptional induction.

glucocorticoid receptor


Input: T., Mahasneh, A., and Cote, G.


Input: RESULTS: The binding of 99mTc d, 1-HMPAO to human placenta ranged from 2. 95% +/-1. 5% to 5. 82% +/-0. 3% per 1 ml standard solution.


Input: CM reduced the nuclear binding activity of transcription factor AP-1.

transcription factor AP-1


Input: NF-kappaB, which is probably important for basal activity of the human NOS II promoter, is unlikely to function as a major effector of CM in DLD-1 cells.

NF-kappaB

human NOS II promoter


Input: RESULTS: The cardiac index significantly changed with varying PaCO2 levels (hypocapnia,-9%; hypercapnia, 13%).


Input: Sequencing of a 40-kb DNA segment of the FK506 gene cluster from Streptomyces sp.


Input: The predicted domain structures of FkbB and FkbC are analogous to that of FkbA and comprise 30 fatty-acid-synthase (FAS)-like domains arranged in 6 modules.

FkbB

FkbC

FkbA

fatty-acid-synthase

FAS


Input: The cwg2-1 mutation was identified as a guanine to adenine substitution at nucleotide 604 of the coding region, originating the change A202T in the cwg2p.

cwg2-1 mutation


Input: Handling on PND 9 did not result in elevated CORT levels in any of the groups.


Input: 633 +/-258 aggregates/ml at 0 rpm; P < 0. 001).


Input: These results indicate that the total number of subunit c in F0 should be a multiple of 2 and 3.


Input: BACKGROUND: The c-myc proto-oncogene has been suggested to play key roles in cell proliferation, differentiation, transformation and apoptosis.

c-myc proto-oncogene


Input: AMY-1 was localized in the cytoplasm in cells expressing c-myc at low levels, but in the nucleus in the cells of a high c-myc expression in transiently transfected cells.

c-myc

c-myc


Input: Antidepressant-like properties of some serotonin receptor ligands and calcium channel antagonists measured with the forced swimming test in mice.

serotonin receptor


Input: The various available data strongly suggesting an environmental toxic origin for the " sperm fall " will be presented as well as the most frequently suspected class of substances, the xenoestrogens.


Input: Examination of DNA: protein binding complexes by gel-shift analysis indicated that nuclear factors from both proliferative and growth-arrested cells bound to the DNA fragment spanning-949--722 bp.


Input: RESULTS: An herpetic seroconversion is observed with presence of type I herpes simplex virus (HSV I) nucleic acids in the recipient' s aqueous humor.


Input: GH failed to stimulate phosphorylation or activation of Jun N-terminal kinase under the conditions used.

GH

Jun N-terminal kinase


Input: CD4 lymphocyte and viral load levels suggested an optimal response to ARV therapy at the time LD developed.


Input: By DNase I footprint analysis of the PNR element, a palindrome of two high-affinity Ets-binding sites (CTTCCCTGGAAG) was identified.

DNase I

Ets-binding sites


Input: No mutations were found in follicular adenomas.


Input: Expression of lacZ from the promoter of the Escherichia coli spc operon cloned into vectors carrying the W205 trp-lac fusion.

lacZ

Escherichia coli spc operon

trp

lac


Input: RT-PCR analysis showed that PLP-H as well as PLP-C and PLP-D are expressed in all rat strains examined, confirming that PLP diversity is not due to strain differences.

PLP-H

PLP-C

PLP-D

PLP


Input: Molecular cloning and characterization of a new member of the rat placental prolactin (PRL) family, PRL-like protein H.

rat placental prolactin

PRL

PRL

protein H


Input: Thus, we have identified an activation target of a human activator, Oct-1, within its cognate basal transcription complex.


Input: The results raise the possibility that pH induced post-translational modifications of DdRPA are involved in events that halt cell proliferation and induce differentiation in Dictyostelium.

DdRPA


Input: P-CIP1, a novel protein that interacts with the cytosolic domain of peptidylglycine alpha-amidating monooxygenase, is associated with endosomes.

peptidylglycine alpha-amidating monooxygenase


Input: In this study we provide evidence that B-Myb is a direct physiological target for cyclin A/Cdk2.

B-Myb

cyclin A


Input: The highly amyloidogenic 42-residue form of Abeta (Abeta42) is the first species to be deposited in both sporadic and familial AD.

Abeta


Input: This model is supported by experiments showing that Cdr2 associates with the N-terminal regulatory domain of Wee1 in cell lysates and phosphorylates Wee1 in vitro.

N-terminal regulatory domain of Wee1


Input: RESULTS: Significant changes from pretreatment to posttreatment were observed (p < 0. 001).


Input: The tip of the button caused a perforation of the posterior stomach wall, leading to death.


Input: Also, the amplitude of the oscillatory potentials (O1 + O2 + O3 + O4) was significantly reduced in the early postoperative period.


Input: Both NUP98-HOXA9 chimeras transformed NIH 3T3 fibroblasts, and this transformation required the HOXA9 domains for DNA binding and PBX interaction.

HOXA9 domains

PBX


Input: Ethylene is involved in endosperm rupture and high-level betaGLU I expression; but, it does not affect the spatial and temporal pattern of betaGLU I expression.

betaGLU I

betaGLU I


Input: The divergence in primary structure between the sheep CRF1 and the other mammalian CRF1s is primarily localized to the extracellular amino terminal domain of the receptor (18 of 22 divergent residues, ovine vs human CRF1).

mammalian CRF1s

human CRF1


Input: Agonist-induced receptor internalization, determined as the percent of total [125I] Tyr0-oCRF bound located in the acid-resistant fraction of transfected Cos 7 cells, increased with time (0-60 min at 37 degrees C) for both wild-type and variant oCRF1.


Input: This c-Jun activity is inhibited by c-Fos, another protooncoprotein that can dimerize with c-Jun to form the transcription factor AP-1.

c-Jun

c-Fos

c-Jun


Input: CONCLUSION: Our study shows that (1) total body BMD and femoral neck BMD were significantly higher in the study group that performed weight-bearing exercises than in control subjects, (2) swimming exercise had no effect on BMD, and (3) although swimming is not a bone-building exercise, it can significantly improve shoulder, back, and grip muscle strength.


Input: Comparisons with other known germins and germin-like proteins indicate that these Arabidopsis GLP subfamilies are unique from wheat germin.

germins

germin-like proteins

GLP

germin


Input: However, there has not been any evidence of A. salmonicida infections, specifically furunculosis, associated with the fish in this loch.


Input: Improving the evidence base for anaesthesia.


Input: Plasma CCK levels were determined at regular intervals.

CCK


Input: Consistent with these findings, relatively weak transcriptional silencing by the native VDR was observed using the osteopontin VDRE.

VDR

osteopontin


Input: A motif (TGATGTCA) which matches a CREB site and is similar to an AP-1 site is embedded within ER2.

CREB site

AP-1 site


Input: Conventionally, four nominal allotypic variants, b4, b5, b6 and b9 have been shown to be co-dominantly expressed at the Ckappa1 gene locus.

Ckappa1 gene locus


Input: Therefore, in order to search for the latent genes, we used allotype-specific oligonucleotides for b5, b6 and b9 to probe DNAs from both normal and T. brucei-infected rabbits by Southern blotting.


Input: TRAF2 is known to associate with TRADD, and expression of a dominant-negative N-terminal deletion TRAF2 mutant was found to partially inhibit LMP1-induced JNK activation in 293 cells.

TRADD

TRAF2 mutant

JNK


Input: These data further define a role for TRADD and TRAF2 in JNK activation and confirm that LMP1 utilizes signalling mechanisms used by the TNF receptor/CD40 family to elicit its pleiotropic activities.

TRADD

JNK

TNF receptor


Input: Epstein-Barr virus-encoded latent membrane protein 1 activates the JNK pathway through its extreme C terminus via a mechanism involving TRADD and TRAF2.

Epstein-Barr virus-encoded latent membrane protein 1

JNK

TRADD


Input: In contrast, transiently transfected cells expressing EBNA-3 revealed a sixfold increase in EBNA-3 protein expression from the genomic EBNA-3 gene compared to EBNA-3 cDNA.

EBNA-3 protein

EBNA-3 gene

EBNA-3 cDNA


Input: However, serial passages of fetal lamb kidney (FLK) cells, which are sensitive to infection with BLV, after transient transfection revealed that mutation of a second tyrosine residue in the N-terminal motif completely prevented the propagation of the virus.


Input: To search for transcriptional regulators, we used a fragment of the SpHE promoter containing several individual elements instead of the conventional bait that contains a multimerized cis element.

SpHE promoter


Input: As expected for a positive SpHE transcriptional regulator, the timing of SpEts4 gene expression precedes the transient expression of SpHE in the very early sea urchin blastula.

SpHE transcriptional regulator

SpEts4 gene

SpHE


Input: Induction of anaesthesia was standardised: fentanyl (3 micrograms/kg), thiopentone (5 mg/kg), atracurium (0. 4 mg/kg).


Input: Conserved and distinct roles of kreisler in regulation of the paralogous Hoxa3 and Hoxb3 genes.

kreisler

Hoxb3 genes


Input: Moreover, this enhancement of transcriptional activation by COUP-TFI requires specifically the AF-1 transactivation function of ER and can be observed in the presence of E2 or 4-hydroxytamoxifen but not ICI 164384.

COUP-TFI

ER


Input: Recombinant Ffh has a melting point of tm = 89 degreesC.

Recombinant Ffh


Input: This region of hsp90 mediates ATP-independent chaperone activity, overlaps the hsp90 dimerization domain, and includes structural elements important for steroid receptor interaction.

hsp90 dimerization domain

steroid receptor


Input: The RNA polymerase III-recruiting factor TFIIIB induces a DNA bend between the TATA box and the transcriptional start site.

RNA polymerase III-recruiting factor TFIIIB


Input: Analysis of hematopoietic growth factor prescriptions in 19 french cancer centers

hematopoietic growth factor


Input: Chem.


Input: These results suggest that the c-met gene is also a target of p53 gene regulation.

c-met gene

p53 gene


Input: Pokeweed antiviral protein (PAP) from Phytolacca americana is a highly specific N-glycosidase removing adenine residues (A4324 in 28S rRNA and A2660 in 23S rRNA) from intact ribosomes of both eukaryotes and prokaryotes.

Pokeweed antiviral protein

PAP

N-glycosidase

28S rRNA

23S rRNA


Input: Among these 360 ZFPs, a novel ZFP cDNA named HFHZ (human fetal heart ZFP) with sequence homology to a Kruppel-associated box (KRAB) was identified.

ZFPs

ZFP cDNA

HFHZ

human fetal heart ZFP

Kruppel-associated box

KRAB


Input: The 3. 3-fold higher expression in the fetal heart than in the adult heart suggests that HFHZ mRNA is downregulated in the process of development.

HFHZ mRNA


Input: CONTEXT: ThinPrep, AutoPap, and Papnet are 3 new technologies that increase the sensitivity and cost of cervical cancer screening.


Input: Experiments on narcotized cats demonstrated that the derivatives of 2-mercaptobenzimidazole possessing the properties of specific bradycardic agents and coded as CM-251, CM-266, and CM-345, reduce the mean rise of segment ST on numerous leads of the epicardial electrogram during 5-min occlusion of the anterior descending branch of the left coronary artery.


Input: Expression of the second gene (XT3) was found to be conserved in human kidney, and partial sequence was obtained from a human cDNA library.


Input: Internal modes of a soliton.


Input: (2) Erythroid 32D Epo1 cells showed a lower level of bulk PKC catalytic activity, lacked the expression of epsilon and eta PKC isoforms, and showed a weak or absent upregulation of the remaining isoforms, except betaI, upon readdition of Epo to growth factor-starved cells.

PKC

epsilon and eta PKC isoforms

betaI

Epo


Input: We used expression cloning to identify interleukin-6 (IL-6) as one factor that suppressed growth of a pre-B-cell variant line, 1A9-M.


Input: Airflow through the dust trap was controlled with a vacuum pump.


Input: Several mutations disrupted the endonuclease and helicase activities; however, only one amino-terminal-charge cluster mutant protein (D40A-D42A-D44A) completely lost AAV hairpin DNA binding activity.

helicase

amino-terminal-charge cluster mutant protein


Input: Here we describe the identification and characterization of several Sp100 splice variant proteins and support their existence by elucidation of the 3'-end of the Sp100 gene.

Sp100 splice variant proteins

Sp100 gene


Input: It was demonstrated that the processing signals in the transcript, i. e. both donor splice sites and the polyadenylation site located in the muscle-specific intron, have to be weak.


Input: Chirality-glass and spin-glass correlations in the two-dimensional random-bond XY model.


Input: Echo modulation in Pr3 +: YAlO3.


Input: Mechanisms of visible-light emission from electro-oxidized porous silicon.


Input: Optically detected librons and phonons in crystalline C60.


Input: Factors influencing direct-immersion (DI)-SPME process were also checked and chosen experimentally.


Input: In contrast, an amino-terminal fragment containing the C/H1 domain was sufficient for coactivation of Zta transcription and viral reactivation function.

Zta


Input: In addition, a potent splicing enhancer sequence isolated in the selection specifically binds a 20-kDa SR protein.

20-kDa SR protein


Input: These data suggest that other Ras effectors can collaborate with PI 3-kinase and with each other to activate Pak.

Ras effectors

PI 3-kinase

Pak


Input: Electrophoretic mobility-shift assays performed with the HNF-3 X and Y sites demonstrated that both sites are capable of binding HNF-3alpha and HNF-3beta.


Input: Proteins known to bind the PEPCK CRE include the CRE-binding protein (CREB) and members of the CCAAT/enhancer-binding protein (C/EBP) family.

PEPCK

CRE-binding protein

CREB

CCAAT/enhancer-binding protein

C/EBP


Input: This construct, termed pDeltaCREC/EBP, binds C/EBPalpha and beta but not CREB, yet it confers a nearly complete glucocorticoid response when transiently transfected into H4IIE rat hepatoma cells.

pDeltaCREC

EBP

C/EBPalpha and beta

CREB


Input: Systematic functional analysis of V1a/V2 hybrid receptors showed that the second intracellular loop of the V1a receptor is required and sufficient for efficient coupling to Gq/11, whereas the third intracellular loop of the V2 receptor is required and sufficient for coupling to Gs.

V1a/V2 hybrid receptors

V1a receptor

V2 receptor

Gs


Input: The fatigue exercise showed relatively high blood lactate concentration [12. 5 (SD 2. 6) mmol x l (-1)] and an increase of serum creatine kinase (CK) activity delayed by 2 days [540 (SD 407) U x l (-1)].

serum creatine kinase

CK


Input: New Langevin equations for a translating and simultaneously rotating asymmetric top.


Input: In the brain, muscarinic receptors mediate motor and memory function by interaction with their ligand acetylcholine.

muscarinic receptors


Input: In this study, we investigated the signal transduction pathways that are involved in OM-induced LDLR transcription.

OM

LDLR


Input: The Lp mouse mutant provides a model for the severe human neural tube defect (NTD), cranio-rachischisis.

Lp mouse mutant


Input: Therefore, high set-up accuracy and reproducibility are mandatory.


Input: CPDs at these three sites may partially displace TFIIIA, thereby enabling rapid repair.

TFIIIA


Input: There was no difference in the hormone receptor status between the cases without lymph node metastases and with lymph node metastases,' clandestine' or macrometastases.


Input: Gel filtration, sedimentation velocity, and immunoprecipitation experiments revealed that beta4 is a component of a multisubunit complex (AP-4) that also contains the sigma4 polypeptide and two additional adaptor subunit homologs named mu4 (mu-ARP2) and epsilon.


Input: We show that the mouse genome contains four copies of the ubc-9 gene.

ubc-9 gene


Input: Independent splicing events involve three previously described cassette exons, which are predicted to encode most of the second transmembrane domain.


Input: Each of these genes contains a putative upstream ORF, while STA2 has two additional in-frame AUG codons 5' to the major cistron.


Input: Primary and secondary structural elements required for synthesis of barley yellow dwarf virus subgenomic RNA1.


Input: The H-reflex recovery curve was obtained after stimulation of the median nerve at the elbow and recording from the flexor carpi radialis.


Input: To identify additional non-Sir factors that affect rDNA silencing, we performed a genetic screen designed to isolate mutations which alter the expression of reporter genes integrated within the rDNA.

Sir factors


Input: In this study, we elucidate signaling pathways induced by photodynamic therapy (PDT) with hypericin.


Input: These results indicate that ATF-2 plays a central role in TGF-beta signaling by acting as a common nuclear target of both Smad and TAK1 pathways.

TGF-beta

Smad


Input: FASEB Federal Funding Consensus Conference FY 2000.


Input: Analysis of the protein sequences of these two replicases, together with previously characterized H. pylori plasmid replication proteins, supports the formation of a distinct class of H. pylori plasmid proteins.

replicases

H. pylori plasmid replication proteins

H. pylori plasmid proteins


Input: The algorithm also limited TG to 20 and 64%, apoB to 6 and 20%, and Lp (a) to 15 and 56%, of low-and high-risk groups, respectively.

apoB

Lp (a)


Input: Conformational studies combining secondary structure predictions, CD and NMR spectroscopy together with ELISA assays, showed that the greater is the propensity of the epitope for helix formation the higher is the recognition by anti-K159.


Input: Schwab and England ADL scores in the " off " state were improved by 18% and in the " on " state the scores declined by 2%.


Input: Sequence analysis revealed that the MEMA protein is identical with a 160 kDa nuclear' domain rich in serines' (DRS) protein occurring free in the nucleoplasm and in U2-ribonucleoprotein structures.

MEMA protein

160 kDa nuclear' domain rich in serines' (DRS) protein

U2-ribonucleoprotein structures


Input: Dopaminergic modulation of transcallosal activity of cat motor cortical neurons.


Input: The induced respiratory burst was investigated by the intracellular oxidative transformation of dihydrorhodamine 123 to the fluorescent dye rhodamine 123 via flow cytometry.


Input: JCAHO asks for hospitals' patience.


Input: 25-OH-D3 did not adversely affect animal health at the proposed use level of 99 micrograms/kg feed when replacing vitamin D3 in turkey rations.


Input: As such the findings support existing studies that have identified given social characteristics of drink drivers.


Input: Analysis of lacZ transcriptional fusions shows that the KdgR-binding sites negatively affect the expression of rsmB.

lacZ transcriptional fusions

KdgR-binding sites

rsmB


Input: In the cell-free import assay, beta-catenin rapidly migrates into the nucleus without the exogenous addition of cytosol, Ran, or ATP/GTP.

beta-catenin

Ran


Input: In ischemic and hypoxic hypoxia, a strong correlation was found between cyt a, a3 oxidation level and VO2 in both ischemic and hypoxic hypoxia (r2 =. 90 and. 87, respectively).


Input: Each recombinant product was a fusion protein with a B domain of Staphylococcal protein A (SPA).

Staphylococcal protein A

SPA


Input: Polypyrimidine and ssDNA binding by the isolated VH domain of immunization-induced anti-Z-DNA Ab resembles the activity of natural autoantibodies and suggests that VH-dependent binding to a ligand mimicked by polypyrimidines may play a role in B cell selection before immunization with Z-DNA.

VH domain

VH


Input: INTERVENTIONS: Study patients were randomly divided into four parallel groups to receive either terbinafine 250 mg a day for 12 or 16 weeks (groups T12 and T16) or itraconazole 400 mg a day for 1 week in every 4 weeks for 12 or 16 weeks (groups I3 and I4).


Input: Bacteria can also cause a labyrinthitis acting directly on the inner ear: among these, Treponemas Pallidum, a spirochaete which causes syphilis and Borrelia Burgdorferi, a spirochaete that causes Lyme Disease, must be mentioned.


Input: Initial control of bleeding is similar, but eradication is achieved in fewer sessions with EVL.


Input: Canalith repositioning is the mainstay of treatment.


Input: Solution structure and mechanism of the MutT pyrophosphohydrolase.

MutT pyrophosphohydrolase


Input: The binding of PH domains to Gbetagamma was inhibited by preincubation of Gbetagamma with the GDP-bound but not the GTP-bound form of Gialpha.

PH domains

Gbetagamma

Gbetagamma

Gialpha


Input: Two-dimensional gel electrophoresis of anti-p59fyn immunoprecipitates obtained from non-transformed resting human T lymphocytes resulted in the identification of an oligomeric protein complex which is constitutively formed between Fyn and several additional phosphoproteins (pp43, pp72, pp85, the protein tyrosine kinase Pyk2, as well as the two recently cloned adaptor proteins, SKAP55 and SLAP-130).

Fyn

protein tyrosine kinase Pyk2


Input: The gene structure of Elk1 spans 15. 2 kb and consists of seven exons and six introns.


Input: Sequence analysis suggests that TtrA contains a molybdopterin guanine dinucleotide cofactor and a [4Fe-4S] cluster, that TtrB binds four [4Fe-4S] clusters, and that TtrC is an integral membrane protein containing a quinol oxidation site.

TtrA

TtrB

TtrC


Input: Previous work has shown that spleen necrosis virus (SNV) long terminal repeats (LTRs) are associated with Rex/Rex-responsive element-independent expression of bovine leukemia virus RNA and supports the hypothesis that SNV RNA contains a cis-acting element that interacts with cellular Rex-like proteins.

spleen necrosis virus (SNV) long terminal repeats

Rex

Rex

cellular Rex-like proteins


Input: Online LATCH demonstrates a shift in identification of the library as an isolated unit to an interactive resource center.


Input: We calculated differences in late occlusion rates by the chi2 (chi-square) test, and found these differences were significant (P =. 04).


Input: We describe a genetic system for further characterizing the role of the extreme C-terminus of the beta subunit of E. coli RNA polymerase.

E. coli RNA polymerase


Input: The enhanced binding of c-Abl to DNA containing 5-methylcytosine residues may result from an increased propensity of the double helix to denature locally coupled with a protein-induced reduction in the base stacking interaction.

c-Abl


Input: We further demonstrate that the Stress-Activated-Protein-Kinase (SAPK) target sites of ATF2, Thr69 and Thr71 are not required for the formation of the p300/CBP-ATF2 multiprotein complex.

Stress-Activated-Protein-Kinase

SAPK

CBP


Input: O. novo-ulmi RNA-7, previously believed to be a satellite-like RNA, is shown to be a defective RNA, derived from OnuMV4-Ld RNA by multiple internal deletions.

O. novo-ulmi RNA-7

OnuMV4-Ld RNA


Input: The paramyxovirus fusion (F) protein mediates membrane fusion.

paramyxovirus fusion (F) protein


Input: In the present study, we show that SRm160/300 is required for a purine-rich ESE to promote the splicing of a pre-mRNA derived from the Drosophila doublesex gene.

ESE

Drosophila doublesex gene


Input: The coefficient of determination, r2, of the other scores ranged from 0. 56 to 0. 61.


Input: While determination of the protein content of the formulae gave no valid information, RAST/EAST inhibition was highest for cow' s milk, followed by the partially hydrolysed whey formula, partially hydrolysed whey/casein formula, soy/pork collagen formula, and the amino acid formula.

casein

soy/pork collagen


Input: In light of the importance of GnRHR, the molecular mechanisms underlying the transcriptional regulation of the human GnRHR (hGnRHR) gene become a key issue in understanding human reproduction.

GnRHR

human GnRHR

hGnRHR


Input: Competitive mobility shift assays using either alphaT3-1 nuclear extract or recombinant SF-1 protein clearly indicated that SF-1 is able to interact specifically with this GSE element positioned at-134.

recombinant SF-1 protein

GSE element


Input: Grade 3 mucositis was reported in 1 patient.


Input: In a heterologous transcriptional system in which the upstream regions of oIFNtau were inserted in front of simian virus 40 (SV40) promoter, the regions between bases-654 and-555 were determined as being the enhancer region required for oIFNtau-SV40-CAT transactivation.

oIFNtau

simian virus 40 (SV40) promoter

oIFNtau

CAT


Input: In co-transfection studies, the expression of c-Jun plus c-Fos enhanced the transactivation of oIFNtau-CAT but the expression of GATA-1, GATA-2 or GATA-3 did not.

c-Jun

c-Fos

oIFNtau

CAT


Input: The relatively mild defects observed in Rpd3 mutants suggest that the recently identified Groucho and dCtBP corepressor proteins do not function solely through the recruitment of histone deacetylases.

Rpd3 mutants

Groucho

dCtBP corepressor proteins

histone deacetylases


Input: Both carbachol (100 microM) and EGF (10 nM) induced Ras activation.

EGF

Ras


Input: Dominant negative Sos did not affect carbachol stimulation of HA-ERK2 but inhibited the stimulatory effect of EGF by 60%.

Sos

HA

EGF


Input: Hrs has a FYVE double zinc finger domain, which specifically binds phosphatidylinositol (3)-phosphate and is conserved in several proteins involved in vesicular traffic.

Hrs


Input: Three subgenomes also comprised 15 to 75 nucleotides derived from the 5' part of the NS2 gene.

NS2 gene


Input: The hybrid viruses were found to accumulate to high levels in infected plants, to form stable virions, and to be mechanically transmissible.


Input: Nevertheless cryopreservation of spermatozoa in a medium containing neither SP nor biological substances could offer an acceptable cryoprotection of spermatozoa to be used in assisted fertilization procedures, especially for intracytoplasmic sperm injection.


Input: EMSA with crude nuclear extracts demonstrated that stimulation with CD40L results in the induction of NF-kappaB complexes that bind to each of the three NF-kappaB sites and are composed mainly of p50 and RelB, but also include c-Rel and p65.

NF-kappaB complexes

NF-kappaB sites

RelB

c-Rel


Input: The major transcription factors controlling arginine metabolism in Escherichia coli and Bacillus subtilis, ArgR and AhrC, respectively, are homologous multimeric proteins that form l-arginine-dependent DNA-binding complexes capable of repressing transcription of the biosynthetic genes (both), activating transcription of catabolic genes (AhrC only) or facilitating plasmid dimer resolution (both).

ArgR

AhrC

AhrC


Input: The studied protein fragments consist of residues Arg183-His267 of the human ER and residues Lys438-Gln520 of the rat GR.

human ER

GR


Input: CONCLUSIONS: Turbutest is a valuable tool in asthmatic patients' training, allowing identification and improvement of an inadequate inhalation technique with Turbuhaler.


Input: The potency of the effect of Nim (0. 5 mg. kg-1 i. p.) was similar to that of NBP (10 mg. kg-1 i. p.).


Input: CONCLUSION: NBP pre-treatment or post-treatment markedly enhanced the rCBF to striatum in RMCAO rats.


Input: The aim of this study was to investigate the spontaneous reports of suspected adverse drug reactions, observed in elderly patients (over 65 years of age) in Sicily (Italy) during the period from 1 January 1995 to 31 December 1997.


Input: The high density lipoprotein (HDL) receptor mediates the uptake of cholesterol and cholesteryl esters, substrates for steroidogenesis, from an HDL particle in the adrenal gland and gonads.

high density lipoprotein (HDL) receptor

HDL


Input: Ozagrel, ifenprodil, cinnarizine and dilazep were more effective than pentoxifylline in increasing rCBF at the HPC.


Input: Using sequence information from human BMAL1 (hBMAL1) cDNAs previously reported by our laboratory, we have isolated and characterized cDNAs encoding three splice variants of the mouse BMAL1 (mBMAL1) gene.

human BMAL1

mouse BMAL1


Input: Comparison with the bHLH/PAS family genes revealed that the intron/exon splice pattern of mBMAL1 most closely matches that of the mAhr, which suggests that BMAL1 and Ahr belong to the same subclass and may be derived from a common primordial gene.

bHLH

PAS

mAhr

Ahr


Input: We were able to detect significant differences in functional residual capacity adjusted for weight or height, and compliance of the respiratory system adjusted for weight or lung volume in the ILD infants compared to the healthy controls or infants who had PPHN, indicating that these PFTs were sensitive enough to determine abnormal lung function in this age group.


Input: Classical ligand-activated nuclear receptors (e. g. thyroid hormone receptor, retinoic acid receptor), orphan nuclear receptors (e. g.

thyroid hormone receptor

retinoic acid receptor

orphan nuclear receptors


Input: We have shown previously that in contrast to other extracellular matrix molecules pepsin-solubilized collagen VI (CVI) can stimulate DNA synthesis of various mesenchymal cell types, apparently independent of integrin-mediated signal transduction.

pepsin

collagen VI

CVI

integrin


Input: The enzyme displays optimal activity at about 0. 5 mM pantoate (k (cat) 0. 63 s (-1)) and at pH 7. 8.


Input: Taken together, these results demonstrate that the RP, like the 20S proteasome, is functionally and structurally conserved among eukaryotes and indicate that the plant RPT subunits, like their yeast counterparts, have non-redundant functions.

RP

20S proteasome

plant RPT subunits


Input: Structure and expression of the mouse growth hormone receptor/growth hormone binding protein gene.

mouse growth hormone receptor

growth hormone binding protein gene


Input: Repair of double-strand breaks (DSBs) in chromosomal DNA by nonhomologous end-joining (NHEJ) is not well characterized in the yeast Saccharomyces cerevisiae.


Input: Thus, elongin C is found to oligomerize in solution and to undergo significant structural rearrangements upon binding of two different partner proteins.

elongin C


Input: Gel filtration and co-immunoprecipitation analyses reveal that Mad2p tightly associates with another spindle checkpoint component, Mad1p.


Input: John leonard dawson


Input: Microcirculatory oxygenation and shunting in sepsis and shock.


Input: The present investigation conducted in a population of 258 dentally aware individuals in the age range 20-69 years, was initiated to elucidate the relationship between tobacco smoking and supragingival calculus, taking into account possible confounding factors such as age, gender, oral hygiene and gingival inflammation.


Input: Interaction of HRI with Hsc70 was required for the transformation of HRI, as the Hsc70 antagonist clofibric acid inhibited the folding of HRI into a mature-competent conformation.

HRI

HRI

HRI


Input: In the budding yeast, Saccharomyces cerevisiae, replicators can function outside the chromosome as autonomously replicating sequence (ARS) elements; however, within chromosome III, certain ARSs near the transcriptionally silent HML locus show no replication origin activity.

HML locus


Input: These results suggest that, for the HML ARS cluster (ARS303, ARS320, and ARS302), inactivity of origins is independent of local transcriptional silencing, even though origins and silencers share key cis-and trans-acting components.

HML


Input: We report the construction of an approximately 1. 7-Mb sequence-ready YAC/BAC clone contig of 8p22-p23.


Input: The recruitment of constitutively phosphorylated p185 (neu) and the activated mitogenic pathway proteins to this membrane-microfilament interaction site provides a physical model for integrating the assembly of the mitogenic pathway with the transmission of growth factor signal to the cytoskeleton.

neu


Input: ECG-gated myocardial Technetium-99m sestamibi SPECT is a useful technique to measure myocardial perfusion and function simultaneously.


Input: The controversy of significance testing: misconceptions and alternatives.


Input: The arrangement of these cutoff-levels leads to a sensitivity of 85% at a specificity of 55% for Protein S100 when measured by RIA, and to a sensitivity of 77% at a specificity of 61% when measured by LIA.

Protein S100


Input: Null alleles of SAS4 and SAS5 bypassed the role of the Abf1p binding site of the HMR-E silencer but not the role of the ACS or Rap1p binding site.

Abf1p binding site

HMR-E silencer

ACS

Rap1p binding site


Input: RESULTS: 256 Periods of TTP or PUNP were reported by men and 174 by women.


Input: Cytokine-induced NF-kappa B DNA binding activity, RelA nuclear translocation, I kappa B alpha degradation, I kappa B serine 32 phosphorylation, and I kappa B kinase (IKK) activity were blocked by curcumin treatment.

NF-kappa B

RelA

I kappa B alpha

I kappa B

I kappa B kinase

IKK


Input: To estimate the locations of sources with the TF-MUSIC algorithm, we first set the target region on the spectrogram of the somatosensory responses.


Input: Immunohistochemical staining with MIB-1 and p53 antibodies showed low (< 1%) and negative reaction.

p53 antibodies


Input: Two patients with recurrent tumors had high S-phase fractions both on the first resected specimens and at the time of the second operation.


Input: Treatment of unstable angina: role of antithrombotic therapy.


Input: Mutations of the RET gene, encoding a receptor tyrosine kinase, have been associated with the inherited cancer syndromes MEN 2A and MEN 2B.

RET gene

receptor tyrosine kinase


Input: Protein kinase A-Ialpha subunit-directed antisense inhibition of ovarian cancer cell growth: crosstalk with tyrosine kinase signaling pathway.

Protein kinase A-Ialpha

tyrosine kinase


Input: During both encephalopathy episodes, CSF protein and immunoglobulin G (IgG) levels were elevated without an increased IgG index or IgG synthesis rate.

immunoglobulin G

IgG

IgG

IgG


Input: SCOB testing of food-restricted animals, using a multiple fixed ratio (FR)/fixed interval (FI) schedule (FR20: FI120), was conducted prior to each exposure to maintain the operant behavior; the data from Weeks-1, 4, 8, and 13 were evaluated for evidence of neurotoxicity.


Input: Differential expression was confirmed by Northern blot analysis employing multiple normal and tumor cell lines.


Input: Several genes or transcriptional units were identified, including the 3' end of ribosomal s6 kinase (Rsk3); two apparently intronless and ORF-less genes; and Gpr31, an intronless, putative G-protein coupled receptor.

ribosomal s6 kinase

G-protein coupled receptor


Input: The results suggest that GATA-5 may have specific downstream targets and that GATA-4,-5, and-6 can only partially substitute for each other in cardiogenesis.

GATA-4,-5, and-6


Input: This study was designed to compare the efficacy of efegatran plus streptokinase versus heparin plus accelerated tissue plasminogen activator (TPA) in coronary reperfusion in acute MI.

streptokinase

tissue plasminogen activator

TPA


Input: From February 1991 to August 1997, 124 patients with endometrial carcinoma were treated postoperatively with high-dose-rate vaginal vault brachytherapy as the only adjuvant treatment.


Input: Twelve patients had stage IBG3, 14 had ICG1, 9 had ICG2, and 3 had ICG3 disease.


Input: For EPV 3, 10, or 40, the bias exceeded 25% for 7, 3, and 1 in the 8-predictor model respectively, when a conventional selection criterion was used (alpha = 0. 05).


Input: Me (2) SO-induced neuronal differentiation of N1E-115 neuroblastoma cells increased both the expression of the endogenous Ntr-1 gene and reporter genes driven by NTR-1 promoter sequences by 3-4-fold.

endogenous Ntr-1 gene

NTR-1 promoter sequences


Input: Although the Src tyrosine kinase induces constitutive Stat3 phosphorylation on tyrosine, activation of Stat3-mediated gene regulation requires both tyrosine and serine phosphorylation of Stat3.

Src tyrosine kinase


Input: RESULTS: Factors associated with significantly (P <. 05) increased risk of treatment failure in a Cox multivariate analysis included age older than 45 years (relative hazard, 1. 17; 95% confidence interval [CI], 1. 02-1. 33), Karnofsky performance score less than 90% (1. 27; 95% CI, 1. 07-1. 51), absence of hormone receptors (1. 31; 95% CI, 1. 15-1. 51), prior use of adjuvant chemotherapy (1. 31; 95% CI, 1. 10-1. 56), initial disease-free survival interval after adjuvant treatment of no more than 18 months (1. 99; 95% CI, 1. 62-2. 43), metastases in the liver (1. 47; 95% CI, 1. 20-1. 80) or central nervous system (1. 56; 95% CI, 0. 99-2. 46 [approaches significance]) vs soft tissue, bone, or lung, 3 or more sites of metastatic disease (1. 32; 95% CI, 1. 13-1. 54), and incomplete response vs complete response to standard-dose chemotherapy (1. 65; 95% CI, 1. 36-1. 99).


Input: The proteasome is a large complex consisting of two multisubunit structures, the 20S and 19S (PA700) or P28 complexes, that combine to form the 26S particles.

P28 complexes

26S particles


Input: We have cloned cDNA and genomic DNA for a mouse gene encoding a protein with significant sequence similarity to conserved domains found in proteins of the Spo11p family.

Spo11p family


Input: RT-PCR and in situ hybridization analyses of a time course of juvenile testis development indicate that Spo11 expression begins in early meiotic Prophase I, prior to the pachytene stage, with increasing accumulation of mRNA through the pachytene stage.


Input: Animals were put to death 8 weeks later and the grafts were sterilely explanted and analyzed via microbiologic culture and standard histologic procedures for evidence of infection.


Input: Oseltamivir (GS4104), which can be administered orally, is the prodrug of GS4071, a potent and selective inhibitor of influenzavirus neuraminidases.

influenzavirus neuraminidases


Input: We also show that activation of protein kinase A (PKA) signaling is sufficient to down-regulate caveolin-1 protein expression and promoter activity.

protein kinase A

PKA

caveolin-1 protein


Input: Phosphatidylinositol 3-kinase requirement in activation of the ras/C-raf-1/MEK/ERK and p70 (s6k) signaling cascade by the insulinomimetic agent vanadyl sulfate.

Phosphatidylinositol 3-kinase

ras

MEK

ERK


Input: For example, introduction of immunogenic and purification tag sequences into the C-terminal coding region significantly decreased bop gene mRNA and protein accumulation.

bop gene mRNA


Input: We recommend that paracervical block with lignocaine should be used in conjunction with i. v. sedation/analgesia during egg collection performed through the transvaginal route under ultrasound guidance (TUGOR) to reduce the pain of the procedure.


Input: This report describes a patient with a previous inferior acute myocardial infarction who developed right ventricular infarction with significant anterior lead ST segment elevation (V1-V4) caused by the loss of two large right ventricular branches during a coronary angioplasty of the right coronary artery.


Input: PURPOSE: Previous WR-2721 human pharmacokinetic studies were limited to plasma levels in patients receiving platinum-based compounds, and none includes the effects of WR-2721 on endogenous thiols.


Input: CONCLUSIONS: In addition to the superiority of octafluoropropane-filled microspheres to air-filled microspheres for LV opacification, the efficacy of OCTA is relatively unaffected by impaired LV function and is less susceptible to the effects of poor echogenicity than AIR.


Input: These kinases belong to a new subfamily related to the Trk subfamily.

Trk subfamily


Input: The data indicate that etr-1 is essential for muscle development in C. elegans, perhaps by playing a role in post-transcriptional processing of some muscle component, and thus suggesting a possible conservation of gene function with human CUG-bp.

human CUG-bp


Input: Detection of poisoning by Impila (Callilepis laureola) in a mother and child.


Input: In HCMV (Towne)-infected HF cells at 24 to 48 h, IE2 also accumulated in newly formed viral DNA replication compartments containing the polymerase processivity factor (UL44), the single-stranded DNA binding protein (SSB; UL57), the UL112-113 accessory protein, and newly incorporated bromodeoxyuridine (BrdU).

polymerase processivity factor

single-stranded DNA binding protein

SSB

UL112-113 accessory protein


Input: Macroscopic researches on heart vascularization have indicated that the angioarchitecture of the conducting system differs from that of the normal myocardium.


Input: However, reoperation for bulky cervical disease (group 3) rarely results in normal calcitonin levels and is associated with a high incidence of permanent hypoparathyroidism.

calcitonin


Input: We present a case of carcinoma of the breast presenting concurrently with SSc that subsequently progressed to dialysis-dependent renal failure in just 1 month.


Input: The GPI anchor moiety is either absent or present at a very low level in the polypeptide expressed from the cDNA that contained both the signal peptide and GPI signal sequences.


Input: They self-completed the SF-36 questionnaire and their QoL was described and retrospectively compared to that of historical controls.


Input: There was a trend toward an association between IENF and sural nerve unmyelinated fiber densities (r = 0. 32, p = 0. 054).


Input: FISH using a whole chromosome 4 paint demonstrated multiple rearrangements involving chromosome 4 in MCF-7 AdVp3000 and MCF-7 MX, while S1-M1-80 contained only a simple reciprocal translocation.


Input: The MXR gene encodes a half-transporter and the absence of cytogenetic evidence of coamplification of other regions suggests that a partner may not be overexpressed, and instead the MXR half-transporter homodimerizes to mediate drug transport.

MXR gene

MXR half-transporter


Input: Serum insulin-like growth factor I (IGF-I) SD score increased from-2. 2 and-4. 2 in men and women, respectively, to 1. 8 and-0. 9 at 6 months and 0. 8 and-0. 7 at 12 months.

Serum insulin-like growth factor I

IGF-I


Input: The level of serum creatine kinase was significantly high 2 days after ESWIB, but it recovered in a week.

serum creatine kinase


Input: Several 7SL RNA-encoding sequences and various intergenic spacers were amplified from the individual HindIII fragments of about 1. 3 and 2. 8 kb.

7SL RNA-encoding sequences

HindIII fragments


Input: Analysis of its genomic region revealed that the 13-kb Cdc6 gene is divided into 12 exons by 11 introns.

Cdc6 gene


Input: Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo.

myosin-binding subunit

MBS

myosin phosphatase

Rho-kinase


Input: Because the Pit-1 sites in the hGH-N gene promoter are insufficient for such gene activation in vivo, these data suggested a unique chromatin-mediated developmental role for Pit-1 in the hGH LCR.

Pit-1 sites

hGH-N gene promoter

hGH LCR


Input: Recombinant prenylcysteine lyase was produced in a baculovirus-Sf9 expression system.

Recombinant prenylcysteine lyase


Input: Mycoplasma hominis infections are easily missed because conventional methods for bacterial detection may fail.


Input: For this purpose, we used a series of plasmid constructs encoding different forms of the envelope glycoprotein E of the flavivirus tick-borne encephalitis virus.

envelope glycoprotein E of the flavivirus tick-borne encephalitis virus


Input: By an induced-fit mechanism, contacts with the anticodon can activate formation of a robust transition state at a site over 70 A away.


Input: This revealed a minimum of six novel OSBP-related proteins, designated ORP-1 to ORP-6.

OSBP-related proteins


Input: In conclusion: (i) TECRA kit is suggested to be used for screening SE producing strains; (ii) SET-RPLA and RIDASCREEN kits are suitable for epidemiological investigation of SE types, but the lack of ability for detecting SEE, long time required for testing with SET-RPLA kit and high background when using RIDASCREEN kit must be overcome; and (iii) because of the complicated test procedures and the lack of ability for detecting SEE, the practicality of SET-EIA kit in screening and epidemiological research purposes is low.


Input: Comparison of immunoassay kits for detection of staphylococcal enterotoxins produced by Staphylococcus aureus

staphylococcal enterotoxins


Input: Sequence analysis of the promoter region showed no TATA box but identified consensus binding motifs for Sp1, CREB, and half sites of the estrogen receptor binding site.

CREB

estrogen receptor binding site


Input: Sak kinase gene structure and transcriptional regulation.

Sak kinase


Input: Based on a type I error of 0. 05, our study had a power greater than or equal to 75% to detect group differences in treatment effect of greater than or equal to 15% to 20%.


Input: However, no genetic alteration was detected in any of the cancers examined.


Input: Statins: lower lipids and better bones? Although statins are widely used as cholesterol-lowering drugs, a recent study suggests that these compounds have anabolic effects on bone and could be developed into new treatments for common metabolic bone diseases such as osteoporosis

Statins


Input: Leukocyte cultures, prepared from blood drawn from these 18 children at 6 months of age, produced lower yields of IFN than those of the remaining 53 children, when stimulated with adenovirus (P < 0. 001), coronavirus (P < 0. 001) or rhinovirus (P = 0. 002).

IFN


Input: In the BF ECT group the-age based dose would have been similarly dependent on the initial seizure threshold level.


Input: Haycocknema perplexum n. g., n. sp.


Input: Hypothermia After Cardiac Arrest (HACA) Study Group.


Input: Two US commercial cultivars (Tehama and Vina), three European commercial cultivars (Esterhazy, 139, G120) and five New Zealand selections (Rex, Dublin' s Glory, Meyric, McKinster, Stanley) were evaluated.


Input: Previously, we showed that the APRE is a cytokine [tumor necrosis factor-alpha (TNFalpha)]-inducible enhancer by binding the heterodimeric nuclear factor-kappaB (NF-kappaB) complex Rel A x NF-kappaB1.

tumor necrosis factor-alpha

TNFalpha

heterodimeric nuclear factor-kappaB

NF-kappaB

Rel A


Input: Angiotensin II induces nuclear factor (NF)-kappaB1 isoforms to bind the angiotensinogen gene acute-phase response element: a stimulus-specific pathway for NF-kappaB activation.

Angiotensin II

nuclear factor (NF)-kappaB1 isoforms

angiotensinogen gene

NF-kappaB


Input: Arhythmacanthus Yamaguti, 1935 is maintained as a synonym of Heterosentis because the distinction between two and three hook types is made equivocal when the transition between the apical and subapical hooks is gradual.


Input: We describe a case of acetaminophen overdose that was treated with both hemodialysis (HD) and NAC due to severe intoxication and slow drug clearance.


Input: Following conditioning, a single coat of adhesive was applied and light-cured.


Input: Upon tyrosine phosphorylation at the ITIMs, these molecules recruit SH2 domain-containing phosphatases such as SH2-containing tyrosine phosphatase-1 and negatively regulate cell activity.

tyrosine phosphatase-1


Input: These results suggest that VP1 was efficiently transported to the nucleus and localized in the discrete subnuclear regions, possibly with VP2 and VP3.


Input: The case for completing the lymphadenectomy when positive lymph nodes are found during radical hysterectomy for cervical carcinoma.


Input: Isolation of cDNAs encoding gibbon and monkey platelet and T cell activation antigen 1 (PTA1).

cDNAs encoding gibbon and monkey platelet and T cell activation antigen 1


Input: All clones and strains produced have been deposited in the EUROFAN genetic stock centre (EUROSCARF, Frankfurt).


Input: High resolution computed tomography of the lungs in patients with rheumatoid arthritis.


Input: Actins show two different forms of N-terminal processing dependent on their N-terminal sequence.

Actins


Input: All four domains were linked via proline-threonine-rich peptides.


Input: METHODS: The former group included patients who had been treated with at least four PGE1 alpha-ciclodestrina, short-term treatment cycles per year while the latter was a historical reference group managed without prostaglandins.


Input: Zebrafish cyclops (cyc) encodes a Transforming Growth Factor beta (TGFbeta) signaling factor closely related to mouse Nodal.

cyclops

cyc

Transforming Growth Factor beta

TGFbeta

Nodal


Input: The genome organization of the mite-transmitted wheat streak mosaic virus (WSMV) appears to parallel that of members of the Potyviridae with monopartite genomes, but there are substantial amino acid dissimilarities with other potyviral polyproteins.


Input: The two-hybrid assay was then performed using full-length genes of CI, HC-Pro, P1, P3, and CP, but no heterologous interactions were detected.

CI

HC-Pro

CP


Input: Diverse endogenous light chains contribute to basement membrane reactivity in nonautoimmune mice transgenic for an anti-laminin Ig heavy chain.

anti-laminin Ig heavy chain


Input: Mechanisms of tachyphylaxis in regional anesthesia of long duration


Input: Dermatology is no exception.


Input: Molecular cloning of a novel human I-mfa domain-containing protein that differently regulates human T-cell leukemia virus type I and HIV-1 expression.

human I-mfa domain-containing protein


Input: The central (R) domain is responsible for receptor-binding activity whereas the N-terminal (T) domain mediates translocation, the process by which the C-terminal cytotoxic domain is transported from the receptor to the site of its cytotoxicity.


Input: We have previously demonstrated that expression of the gene for the reproductive neuropeptide, GnRH, is repressed by the glutamate/NO/cyclic GMP (cGMP) signal transduction pathway through cGMP-dependent protein kinase in the hypothalamic GnRH-secreting neuronal cell line GT1-7.

GnRH

cGMP-dependent protein kinase

GnRH


Input: MSSPs are believed to regulate DNA replication, transcription, apopotosis and cell cycle progression by interacting with the C-MYC protein.

MSSPs

C-MYC protein


Input: As no complete PPARgamma antagonists have been described hitherto, we have constructed a dominant-negative mutant receptor to inhibit wild-type PPARgamma action.

PPARgamma

PPARgamma


Input: Forty 4-month old SD female rats were randomly divided into four groups, namely sham operation, bilateral ovariectomy, ovariectomy plus supplementary ethinyl estradiol (0. 2 microgram/100 g B.


Input: The requirement of 3' complementarity for a ligation reaction is reaffirmed by results from 1 nt insertions on either the 3'-or 5'-side of the nick.


Input: Expression in early postnatal pituitary and in pre-somatotrophic cells suggests that Zn-16 could play a role in pituitary development prior to somatotroph differentiation.


Input: Mouse growth hormone transcription factor Zn-16: unique bipartite structure containing tandemly repeated zinc finger domains not reported in rat Zn-15.

Mouse growth hormone transcription factor Zn-16

rat Zn-15


Input: The CCAAT core sequence mutants in which both CIII and CI/CII were abolished, also increased the promoter activity.


Input: Finally, the mechanism of ASK1 activation involves, in part, homo-oligomerization.


Input: Two other patients underwent PRFR.


Input: The variations were caused by opposite shifts in TSH frequency distribution in mothers and neonates.

TSH


Input: However, such a mechanism was not detected in preliminary observations on M. synoviae.


Input: The expression of the yam8 (+) cDNA in the mid1 mutant cells partially remediated the mid phenotype and resulted in a slight increase in Ca (2 +) uptake activity.

yam8 (+) cDNA

mid1 mutant


Input: TIP30 has an intrinsic kinase activity required for up-regulation of a subset of apoptotic genes.


Input: Alternatively, PC12-E2 cells were submitted to treatment with antibodies to the fibroblast growth factor (FGF) receptor, inhibitors of the nonreceptor tyrosine kinase p59 (fyn), PLC, PKC and MEK and an activator of PKC, phorbol-12-myristate-13-acetate (PMA).

fibroblast growth factor (FGF) receptor

nonreceptor tyrosine kinase p59

fyn

PLC

PKC

MEK

PKC


Input: Approximately 20% of ALCLs that express ALK do not contain the t (2; 5), suggesting that other genetic abnormalities can result in aberrant ALK expression.

ALK

ALK


Input: In addition, expected decreases in ATIC enzymatic function in ATIC-ALK-containing lymphomas may render these tumors more sensitive to antifolate drugs such as methotrexate.

ATIC

ATIC

ALK


Input: Manganese ions were found to be essential for autophosphorylation of BGLF4, and magnesium can stimulate the activity.


Input: An amino-acid sequence comparison revealed that Bacillus YM55-1 aspartase shared 71% homology with Bacillus subtilis aspartase and 49% with Escherichia coli and Pseudomonas fluorescens aspartases.

Bacillus YM55-1 aspartase

Bacillus subtilis aspartase

Pseudomonas fluorescens aspartases


Input: Unique to this system, the activity of TraR is negatively modulated by an antiactivator called TraM.

TraR

TraM


Input: As assessed by a genetic assay that measures AAI-dependent DNA binding, TraM inhibited TraR function before and after the transcription factor had bound to its DNA recognition site.

TraM

TraR


Input: Collectively, the results suggest that ARF binding to Mdm2 induces a conformational change that facilitates nucleolar import of the ARF-Mdm2 complex and p53-dependent cell cycle arrest.

ARF

ARF


Input: The AtERF genes were differentially regulated by ethylene and by abiotic stress conditions, such as wounding, cold, high salinity, or drought, via ETHYLENE-INSENSITIVE2 (EIN2)-dependent or-independent pathways.

AtERF genes


Input: Electrophoretic mobility shift assays revealed that Sp1 binds to two different regions in the proximal promoter, a typical Sp1 site located at (-38;-33) and a G/C-rich region between (-67;-62).

Sp1 site


Input: Eight patients received 1. 5 mg of adefovir dipivoxil per kg of body weight, and six patients received 3. 0 mg of adefovir dipivoxil per kg.


Input: Most likely they might represent regulatory RNAs or transcribed transposable elements.


Input: Here we describe the cloning, tissue-specific expression pattern, and functional characterization of two novel TEF-1 isoforms, TEF-1beta and TEF-1gamma.

TEF-1 isoforms


Input: The comparison of the expression patterns of the known Kv4 family members shows subtype specificity with significant overlaps.

Kv4 family members


Input: Preliminary use of the Nottingham Eczema Severity Score would support further development as a research tool for a simple assessment of disease severity that could be used in epidemiological studies.


Input: Advanced adenoma was defined as an adenoma larger than 10 mm or an adenoma of any size with villous component, high-grade dysplasia or invasive carcinoma.


Input: To understand whether Shc localization in membrane rafts is sufficient to regulate Shc function, we constructed a Shc chimera containing the Ras membrane localization motif at the C-terminus.

Shc

Shc

Shc chimera

Ras membrane localization motif


Input: RegA is a positive yet nonessential regulator of tol-oprL expression.

RegA

tol

oprL


Input: Schlegel, J.


Input: The early dg. of rejection and especially acute rejection, it' s adequate management, decreased risk for the future chronic rejection nephropathy.


Input: Extracellular-regulated kinase (ERK) activation and molecular coupling of the adaptor proteins p130 Crk-associated substrate (CAS) and c-CrkII (Crk) represent two distinct pathways that induce cell invasion and protect cells from apoptosis in a three-dimensional collagen matrix.

Extracellular-regulated kinase

ERK

p130 Crk-associated substrate

CAS

c-CrkII

Crk

collagen


Input: The evolution of the CCR5 cis-regulatory region versus the open reading frame as well as among different domains of the open reading frame differed from one another.

CCR5 cis-regulatory region


Input: Scanning mutations throughout the AC element interfered with induction but allowed us to define five overlapping sites for regulatory factors in AC and to design probes binding just one or two factors.


Input: Bites by two species of adders (Vipera aspis and Vipera berus) can lead to extensive swelling with multiorgan failure.


Input: CONCLUSION: Treatment of sepsis with the platelet-activating factor antagonist BB-882 offers no advantage over placebo on survival, hemodynamic status, respiratory function, or organ failure scores.

platelet-activating factor


Input: In vivo dimethyl sulfate footprinting of the cyclin E promoter revealed several regions of protection and hypersensitivity that were unique to infected cells.

cyclin E promoter


Input: A total of 194 STSs map to this interval of 3 Mb, giving an average marker resolution of approximately one per 15 kb.


Input: Recently, a mutation in the amino-terminus of IB1 was associated with diabetes.


Input: Biol.


Input: These data show that the alpha-helix domain of p57 (Kip2), which is conserved in the Cip/Kip proteins, is implicated in protein-protein interaction and confers a specific regulatory mechanism, outside of their Cdk-inhibitory activity, by which the p57 (Kip2) family members positively act on myogenic differentiation.

Cip

Kip

Cdk


Input: The somatoform conundrum: a question of nosological valves.


Input: Intra-operative ultrasound (IOUS) has been widely used in an attempt to overcome these difficulties, but is limited by its two-dimensional nature, inter-user variability, and image obliteration with ablative or resectional techniques.


Input: CONCLUSIONS: This randomized study shows that Vivostat fibrin sealant is effective in preventing air leakage after small lung resections in pigs, even at high inspiratory pressures.

fibrin


Input: Hailey-Hailey disease is caused by mutations in ATP2C1 encoding a novel Ca (2 +) pump.


Input: A cause of increase of alkaline phosphatase in children

alkaline phosphatase


Input: Significantly, two proximal GATA-1-binding sites (-118/-113 and-98/-93) and a region located within-518 to-315bp of the mouse ALAS2 promoter were essential for transcriptional activation during chemically induced differentiation of MEL cells, implying their importance in conferring erythroid specificity to the ALAS2 transcriptional activation.

GATA-1-binding sites

mouse ALAS2 promoter


Input: The HMG domain of both HMG20 proteins is most similar to that of yeast NHP6A (38% to 42%).

HMG domain

HMG20 proteins

yeast NHP6A


Input: IgM and IgG anti A and anti B antibody status of 100 antenatal O group mothers (who had non O group husbands) were studied.

IgM

IgG anti A

anti B antibody


Input: In an attempt to understand Wee1 regulation during cell cycle, yeast two-hybrid screening was used to identify Wee1-binding protein (s).

Wee1-binding protein (s)


Input: Retroviral transduction of T/T (L) causes a rapidly fatal myeloproliferative disease in a murine bone marrow transplant (BMT) model, whereas T/T (F) causes a long-latency, pre-B-cell lymphoblastic lymphoma.

T/T (L)

T/T (F)


Input: The codon usage is particularly marked for the gag, pol, and env genes.

gag

pol

env genes


Input: Slap negatively regulates Src mitogenic function but does not revert Src-induced cell morphology changes.

Slap

Src

Src


Input: We examine current models of the effects of aging on mean response time and show how they might be reinterpreted.


Input: The effects of these mutations on protein function require further examination.


Input: Kaposi' s sarcoma-associated herpesvirus viral interferon regulatory factor confers resistance to the antiproliferative effect of interferon-alpha.

viral interferon regulatory factor

interferon-alpha


Input: AMDA white paper identifies ways to improve pharmaceutical care in SNFs.


Input: Because the mutant defective in DNA binding also fails to stimulate Abf1 ARS1 DNA-binding activity, our results suggest that Cdc6 DNA-binding activity may play a pivotal role in the initiation of DNA replication.


Input: The structural study of peptides belonging to the terminal domains of histone H1 can be considered as a step toward the understanding of the function of H1 in chromatin.

histone H1


Input: The recovery rates for the MB/BacT, MGIT 960, and solid media were 91. 6, 87. 4, and 54. 7%, respectively, for all mycobacteria; the recovery rates were 93. 6, 88. 9, and 63. 4%, respectively, for M. tuberculosis complex alone, and 87. 5, 84. 4, and 37. 5%, respectively, for all nontuberculous mycobacteria.


Input: SELECTION CRITERIA: Randomised and possibly randomised trials using acupuncture to treat asthma and asthma-like symptoms.


Input: SELECTION CRITERIA: Randomised trials comparing children undergoing systematic therapy focusing on the family in conjunction with asthma medication, with children taking asthma medication only.


Input: The models were tested by studying their response to disturbances of the afferent signal from the bladder.


Input: We also show that p65 binds to these targets with almost equal affinity and that different residues have variable roles in binding different kappaB targets.

kappaB targets


Input: To illustrate its performance, measurements of photoluminescence in GaAs/AlGaAs heterostructures are presented.


Input: D5/D1 (CT) or D5/D1D (CT) tail substitution mutants displayed a rank order of potency and agonist affinities virtually mimicking wild-type (wt) D1 receptors, as indexed by both ligand binding and dopamine-stimulated cAMP accumulation assays, and, similar to wt D1 receptors, did not exhibit receptor constitutive activity or responsiveness to inverse agonists.

D5/D1 (CT)

D5/D1D (CT)

wild-type (wt) D1 receptors

D1 receptors


Input: Modeling also revealed a very hydrophobic surface due to the absence of H12, exposing residues from H3, loop 3-4, H4, and H11.


Input: The immune system is closely integrated with the neuroendocrine system, and infection-induced increases in cytokines such as IL-1, IL-6 and TNF have numerous effects on the central nervous system.

TNF


Input: Flavonoids from Brosimum acutifolium.


Input: Although the OC promoter is activated in a C terminus dependent manner, the MDR, LTR and BSP promoters are repressed by three distinct mechanisms, either independent of or involving the AML C terminus, or requiring only the conserved C-terminal pentapeptide VWRPY.

OC promoter

MDR

BSP promoters

AML C terminus


Input: Therefore, analogs of vitamin D3 have been investigated in a number of trials showing improvement of psoriasis.


Input: The network evolution was interpreted by an approach based on the Flory model.


Input: Biologically significant amounts of platelet activating factor were eluted from the sorbent during the entire treatment time.

platelet activating factor


Input: Mucin gene expression has been shown to be altered in many intestinal diseases and especially cancers of the gastrointestinal tract.

Mucin gene


Input: E2F-1 is a transcription factor that regulates cell cycle progression into S-phase.


Input: Taken together, these results indicate that MAP kinase stimulates the hPL-B enhancer by an NF-IL-6-dependent pathway.

MAP kinase

hPL-B enhancer


Input: Using adenoviral transfer of IkappaBalpha (IkappaBalpha overexpression), the production of TNF-alpha induced by whole GBS was inhibited by only 20%.

IkappaBalpha

IkappaBalpha

TNF-alpha


Input: The delta srb10 mutation also influenced on the transcript levels of meiosis-inducing genes called IME1 and IME2: the mutation elevated the transcript level of IME1 but reduced that of IME2, resulting in partial defects in premeiotic DNA synthesis and meiosis.

delta srb10 mutation


Input: We also found that environmental conditions for meiosis finely regulate the transcript levels of KIN28 and CCL1, such that nitrogen starvation first elevates them but subsequent alkalization of medium decreases them.


Input: The effect of acute, mid-cervical spinal cord lesions on neuronal and reflex activity evoked by the noxious visceral stimulus, colorectal distension (CRD; 80 mmHg, 20 s), was determined in halothane-anesthetized rats.


Input: The results suggest that the role of S. argyrostoma in the dissemination of Trichinella larvae in nature is limited in comparison to the role played by mammals with scavenger and cannibalistic behavior.


Input: The equilibrium dissociation binding constant for the interaction of TnrA with the nrgAB promoter fragment was 7. 7 nM under the conditions used here.

TnrA

nrgAB promoter fragment


Input: Phd antibody-immunoreactive peptides are seen in light-adapted mouse retinal cytosolic and nuclear extracts.

Phd


Input: In contrast to the morphological criteria, the few data available from recent studies at the genetic level have suggested that EPVs infecting different insect orders are phylogenetically distant.


Input: Prevention, differential diagnosis and therapy of travel diarrhea


Input: Mutation analysis demonstrates that the motif TCCCCT is critical for PyRo1 interaction.


Input: Our results suggest that proteasome inhibition leads to upregulation of specific members of transcription factor families controlling cellular stress response and proliferation.


Input: In hemodialyzed patients (Epo and Non-Epo group) leptin levels were significantly higher when compared to CAPD patients (Epo and Non-Epo group, respectively).

Epo

Epo

leptin

Epo

Epo


Input: ID-PaGIA diphtheria toxin polymer particle diagnostic agent manufactured by DiaMed AG, Switzerland, was tried at bacteriological laboratory of Institute of Childhood Infections in St.

diphtheria toxin


Input: Topics reviewed here include: data supporting the association of myositis with cancer and the appropriate evaluations for malignancy in a myositis patient; an approach to the assessment of patients with dermatomyositis sine myositis; the usefulness of the clinicopathological and serological classifications; a discussion of whether childhood and adult myositis are the same or different entities; a review of those prognostic factors to consider in the clinical management of myositis patients; current approaches and their limitations for assessing disease activity and damage.


Input: The outer diameter and the thickness of the rotor are 60 mm and 8 mm, respectively.


Input: CONCLUSIONS: There is a relation in the topography of some visual field areas assessed by SWAP and the inferotemporal neuroretinal rim area, which may play a role in the diagnosis and follow-up of suspected glaucoma.


Input: ACE-2 has a hydrophobic C terminus of H type.


Input: We concluded that activation of c-fosER mediated transcriptional inhibition of p21 (Cip1/WAF1) through a previously uncharacterized AP-1 site, revealing an important role for c-fos in negative control of cell cycle regulatory genes.

c-fosER

AP-1 site

c-fos


Input: The first symptoms of enzootic calcinosis were noted in March 1998, when some of the cows developed locomotor abnormalities.


Input: Screening, counseling, and treatment for alcohol and illicit drug use should be essential components in comprehensive HBP care.


Input: Transcriptional regulation of the mouse cytosolic chaperonin subunit gene Ccta/t-complex polypeptide 1 by selenocysteine tRNA gene transcription activating factor family zinc finger proteins.

mouse cytosolic chaperonin subunit gene Ccta/t-complex polypeptide 1

selenocysteine tRNA gene transcription activating factor family zinc finger proteins


Input: We have shown that the epidural (EPI) delivery of morphine encapsulated in multivesicular liposomes (DepoFoam drug delivery system) produces a sustained clearance of morphine and a prolonged analgesia.


Input: Following EPI-C0401, but not saline or DepoFoam vehicle, there were transient (< 72 hr) decreases in food consumption, arousal, hindlimb muscle tone, and body temperature.


Input: Resistance ratios for the other field strains obtained by comparison with the R5 strain ranged from 24. 5 to 239 for topical application and from 1. 2 to 9. 8 for the glass jar method.


Input: Reliability of cervical range of motion using the OSI CA 6000 spine motion analyser on asymptomatic and symptomatic subjects.


Input: Activation of PKA by 8-bromo-cyclic AMP or forskolin, and inhibition of PKC by calphostin C, resulted in a significant decrease in 3TP activity as well as in vitro ERK kinase activity in CRAC.

PKA

PKC

ERK kinase


Input: Mus81p also shares homology with motifs found in the XPF endonuclease superfamily.

XPF endonuclease superfamily


Input: Double mutant analysis suggests that Rad54p and Mus81p act in one pathway for the repair of, or tolerance to, UV-induced DNA damage.


Input: SELECTION CRITERIA: All controlled trials where adults with schizophrenia or similar illnesses were randomised to quetiapine, placebo or other neuroleptic drugs and where clinically relevant outcomes were reported.


Input: Six distinct Ets mRNAs were identified: Ets2, Fli1, GABPalpha, SAP1, Elk1, and PE1.

Ets mRNAs

GABPalpha


Input: A 2 kb transcript was isolated from brain that encodes a approximately 57 kDa protein; the predicted protein contains the known N-terminal Ets domain of PE1 and a novel C-terminal domain with signficant homology to murine ERF.

N-terminal Ets domain

murine ERF


Input: Twenty eligible patients with cirrhosis were randomized into two groups: 10 patients treated with 6 million units of natural IFN-beta twice a week for 36 months and 10 patients without IFN therapy.

IFN-beta

IFN


Input: It is now well accepted that the p53 C-terminus plays a central role in controlling the activity of the wild-type molecule.

p53 C-terminus


Input: The transcription factor Jun (c-Jun) functions as a recipient of extracellular growth signals and converts them into patterns of gene expression.

Jun

c-Jun


Input: This compound is the main bioactive metabolite of trimebutine II (Debridat, CAS 39133-31-8), an antispasmodic widely used for intestinal diseases since 1969.


Input: This enabled the formation of stem-loop templates with the fusion point of the chimeric transcript in the loop and the use of MLL primers in two-sided PCR.

MLL


Input: It contains 25 exons coding for a 4. 7kb transcript including large 5'-and 3'-(1218bp and 701bp, respectively) untranslated regions (UTRs).


Input: The limit between the cecum and the ascending colon was externally marked by the sulcus cecocolicus dorsalis and ventralis.


Input: These results further support an important role for CBF2 in mediating EBNA2 transactivation; they identify the hnRNP protein AUF1 as a major component of CBF2 and are also the first evidence of a cis-acting sequence other than a CBF1 binding element that is able to confer responsiveness to EBNA2.

hnRNP protein AUF1

CBF1 binding element


Input: Viruses were isolated from 9 lungs: 7 with PI-3V, 1 with NCP BVDV type 1, and 1 with both BVHV-1 and BVDV.


Input: Splicing of the K-SAM alternative exon of the fibroblast growth factor receptor 2 gene is heavily dependent on the U-rich sequence IAS1 lying immediately downstream from its 5' splice site.

K-SAM

fibroblast growth factor receptor 2 gene


Input: During treatment, the phosphorylation state of Rb shifted to a hypophosphorylated form. mRNA for the HPV E6/E7 genes decreased; however, significant changes in the E7 protein were not observed, while increased levels of Rb immunoprecipitated with anti-E7 antibodies were observed.

Rb

E7 protein

Rb

anti-E7 antibodies


Input: Five of the Aeromonas strains and one of V cholerae non-O1 were positive for enterotoxin activity.


Input: The 2 cDNAs differed in the length of their respective 3' untranslated regions, of 577 bp in Cp. F6 and 72 bp in Cp. F10, in both of which a putative polyadenylation signal was identified.

Cp. F6

Cp. F10


Input: Platelet counts and function as well as fibrinogen and von Willebrand factor (vWF) levels were determined in each sample.

fibrinogen

von Willebrand factor

vWF


Input: The aim of our study was to evaluate the level of oxidative stress in healthy controls (CTL) compared with CRF and HD patients before (pre-HD) and after (post-HD) the dialysis session, carried out on a high biocompatible polyacrylonitrile membrane AN69.


Input: Indirect plasma parameters such as vitamin E, thiol and uric acid levels were also quantified.


Input: The results indicate that the relationship between comprehension and production is different at different stages in development.


Input: On long-term follow-up, there was no significant difference in the incidence of hospitalizations (1 per 2. 1 vs.


Input: The tumor-suppressor protein p53 is involved in maintaining genomic stability.

tumor-suppressor protein p53


Input: Abrogation of p53 function by E6 resulted in an increase in the spontaneous mutation frequencies at the heterozygous thymidine kinase (TK) locus but not at the hemizygous hypoxanthine phosphoribosyl transferase (HPRT) locus.

thymidine kinase

TK

hypoxanthine phosphoribosyl transferase

HPRT


Input: Cytogenetic analysis of LOH mutants by chromosome painting indicated a mosaic of chromosomal aberrations involving chromosome 17, in which partial chromosome deletions, amplifications, and multiple translocations appeared heterogeneously in a single mutant.


Input: These results support a model in which p53 protein contributes to the maintenance of genomic integrity through recombinational repair.

p53 protein


Input: In patients with type II tumors, the pattern of lymphatic spread was primarily directed toward the paracardial, lesser curvature, and left gastric artery nodes; esophagectomy offered no survival benefit over extended gastrectomy in these patients.


Input: The muskox is a new host record for T. gondii.


Input: Mucosal application of NCX-4016, however, did not cause PD reduction and luminal H + loss, but produced a marked hyperemia, resulting in no damage in the stomach of both normal and STZ-diabetic rats.


Input: The amino acid sequence of matrilysin-2 also contains a threonine residue adjacent to the Zn-binding site that has been defined as a specific feature of matrilysin.

matrilysin


Input: Regarding " the relation between sexual orientation and penile size, " by A.


Input: Analysis of Standard Reference Material 1846, Infant Formula, gave a mean value of 0. 95 +/-0. 088 mg vitamin K/kg (K or K1?) (n = 31) with a coefficient of variation of 9. 26.


Input: The Spo0F residues making up the hydrophobic patch are very similar in all response regulators suggesting that the binding is initiated through the same residues in all interacting response regulator-kinase pairs.

Spo0F residues


Input: While mutations in K-Rev that inactivate any one of these properties also blocked K-Rev-dependent nuclear RNA export, several K-Rev mutants were comparable to wild type when assayed for any of these individual activities yet nevertheless defective for RNA export.

K-Rev

K-Rev

K-Rev mutants


Input: These results suggest that Cdc42p is in fact required for pheromone response and that interaction with the PAK Ste20p is critical for that role.

PAK Ste20p


Input: Symptoms, however, appear to correlate poorly with oesophagitis; hence, severe symptoms do not indicate there is greater oesophageal damage.


Input: The variable phenotype of the allotetraploids could not be explained by cytological abnormalities.


Input: It is now estimated that inactivation mutants of PTEN exist in 60% of all forms of solid tumors.

PTEN


Input: We have demonstrated that the activity of ILK is constitutively elevated in PTEN mutant cells.

ILK

PTEN mutant


Input: The detector has the advantage of finding both ST segment deviations and entire ST-T complex changes thereby providing a wider characterization of the potential ischemic events.


Input: Primary adrenal hypersensitivity to ACTH drive in obesity has also been suggested.

ACTH


Input: In addition, a noncanonical C/EBP-binding site within the Gadd45gamma promoter where C/EBPbeta and C/EBPdelta could bind, was identified by electrophoretic mobility shift assay (EMSA) and reporter gene analysis.

C/EBP-binding site

Gadd45gamma promoter

C/EBPbeta

C/EBPdelta


Input: From two inhibitor scaffolds, we have identified potent and selective inhibitors for sensitized kinases from five distinct subfamilies.


Input: By progressive 5'-deletion studies, we have identified a 248-bp DNA fragment (-1018 to-771, relative to the translation start site) at the 5'-flanking region of the human GnRHR gene that is responsible for the GnRHa-mediated down-regulation of human GnRHR promoter activity.

human GnRHR gene

human GnRHR promoter


Input: Intracellular localization studies using the mDAP-3/EGFP fusion protein, cell fractionation and protease protection experiments localized mDAP-3 to the mitochondrial matrix.

EGFP


Input: Reporter gene expression analyses indicate that both WASP promoters show high levels of expression in different hematopoietic cell lines.

WASP promoters


Input: Altogether these results suggest that, in KG1a cells, TNFalpha can stimulate in parallel PC-PLC and PLD, whose lipid products activate in turn mitogen-activated protein kinase (MAP kinase) and NF-kappaB signalling respectively.

TNFalpha

PC-PLC

PLD

mitogen-activated protein kinase

MAP kinase

NF-kappaB


Input: Polysome and 40S ribosome fractions were severely decreased in the krr1 mutant and Kri1p-depleted cells.

40S ribosome

krr1 mutant


Input: They also negatively modulate the PI 3-kinase catalytic activity but to different extents, dependent on the unique N-terminal structure of each isoform.

PI 3-kinase


Input: The Drosophila melanogaster suppressor of sable gene, su (s), encodes a novel, 150-kDa nuclear RNA binding protein, SU (S), that negatively regulates RNA accumulation from mutant alleles of other genes that have transposon insertions in the 5' transcribed region.

Drosophila melanogaster suppressor of sable gene

su (s)

SU (S)


Input: As a result, we have defined two arginine-rich motifs (ARM1 and ARM2) that mediate the RNA binding activity of SU (S).

SU (S)


Input: Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit nuclear factor-kappa B-dependent gene activation at multiple levels in the human monocytic cell line THP-1.

Vasoactive intestinal peptide

pituitary adenylate cyclase-activating polypeptide

nuclear factor-kappa B-dependent gene


Input: Overexpression of Trdpm1 in a dpm1 (+):: his7/dpm1 (+) S. pombe diploid resulted in a 4-fold increase in specific DPM synthase activity.

dpm1 (+)

his7/dpm1 (+)

DPM synthase


Input: The N-terminal small segment of yeast TAF145 (yTAF145) binds to TBP and thereby inhibits TBP function.

yeast TAF145

TBP

TBP


Input: These probable border sequences are closely related to those of other known T-regions and define a second T-region of pTiChry5, called T-right (TR), that confers production of the Amadoriopines.


Input: Another cis-acting element, exonic splicing suppressor 1 (ESS1), represses use of the nt 3225 3' splice site.


Input: 5'-RACE analysis suggested a single transcription initiation site 187 bp upstream from the translational start site.


Input: Thromboelastography is a test that could potentially correlate with the degree of anticoagulation produced by low molecular weight heparin.


Input: Expression of a hybrid protein containing the cytoplasmic C-terminal half of UhpB fused to glutathione S-transferase (GST) also interfered with Uhp signaling.

UhpB

glutathione S-transferase

GST

Uhp


Input: RESULTS: Glaucoma suspects were divided into two groups according to their SWAP results: high risk (with SWAP abnormalities) and low risk (with normal SWAP result).


Input: To begin to understand this role, we overexpressed ATF-2 in a human cancer cell line.


Input: Botulinum toxin A in the treatment of hemiplegic spastic foot drop--clinical and functional outcomes.

Botulinum toxin A


Input: The U17/U16 and the U16 + gene products transactivated the HIV LTR.

U16 + gene products

HIV LTR


Input: The Cili-2 sequences possess similarity to the RNaseH domain of Lian-Aa1, a mosquito non-LTR retrotransposon.

Cili-2 sequences

RNaseH domain

Lian

mosquito non-LTR retrotransposon


Input: This dynamic response strongly suggests that the p53 and Rb tumor suppressor pathways are intact in HeLa cells and that repression of HPV E6 and E7 mobilizes these pathways in an orderly fashion to deliver growth inhibitory signals to the cells.

Rb

HPV E6


Input: Effects of spatial and temporal smoothing on stimulated brillouin scattering in the independent-hot-spot model limit The influence of laser beam smoothing on stimulated Brillouin backscattering (SBBS) is studied analytically in the limit of the independent hot spot model.