{"input": "In the 8 patients the difference betweent he mean diastolic values of delta PU and delta PM was-0. 54 +/-1. 0 (SD) mmHg.", "output": {"entities": {}}, "schema": []}
{"input": "The biochemistry of amniotic fluid with poor fetal growth.", "output": {"entities": {}}, "schema": []}
{"input": "Resistance to the simulated physiologic environment was tested by measured retention of mechanical properties after immersion times in pseudo-extracellular fluid (PECF) at 37 degrees C for as long as three years.", "output": {"entities": {}}, "schema": []}
{"input": "This expression assumes: (1) a laminar flow regimen during expiration, and (2) a constant CT value over the range of VT.", "output": {"entities": {}}, "schema": []}
{"input": "Their conduction velocity ranged from 0. 23 to 0. 98 m/sec (group C).", "output": {"entities": {}}, "schema": []}
{"input": "The major urinary metabolites were 3-(3-carboxyphenyl)-5-hydroxymethyl-2-oxazolidinone and a glucuronide of toloxatone.", "output": {"entities": {}}, "schema": []}
{"input": "The ventilation did not increase when PACO2 was increased.", "output": {"entities": {}}, "schema": []}
{"input": "Changes of thirtynine serum protein components following surgical stress.", "output": {"entities": {}}, "schema": []}
{"input": "These differences are smaller than those described in standard textbooks.", "output": {"entities": {}}, "schema": []}
{"input": "The present study examined the dependence of difference tone level [L (f2-f1)] on the following parameters of the two-tone input: f1, f2/f1 (f2 greater than f1), L1, L2, and L1 = L2.", "output": {"entities": {}}, "schema": []}
{"input": "With certain exceptions the method was considered suitable in the routine intravenous cholangiography.", "output": {"entities": {}}, "schema": []}
{"input": "Delayed mortality of mice following inhalation of acute doses of CH2O, SO2Cl2, and Br2.", "output": {"entities": {}}, "schema": []}
{"input": "Guinea pigs weighing 300 approximately 350 g were used.", "output": {"entities": {}}, "schema": []}
{"input": "None of the cystometrograms showed uninhibited detrusor contractions.", "output": {"entities": {}}, "schema": []}
{"input": "Treatment of Graves' disease.", "output": {"entities": {}}, "schema": []}
{"input": "Allergic reaction to Patent Blue Violet during lymphography.", "output": {"entities": {}}, "schema": []}
{"input": "One-third of the men with azoospermia and with sperm density of less than 10 million had marked FSH elevation and our experience confirms the work of others that this indicates a poor prognosis.", "output": {"entities": {"gene": [{"text": "FSH", "start": 96, "end": 99}]}}, "schema": []}
{"input": "It was concluded that both of these surgical procedures were as effective as pinealectomy in reversing the pineal-induced alterations in the reproductive physiology of the blind-anosmic female rat.", "output": {"entities": {}}, "schema": []}
{"input": "This implies that the groups do not just differ along one dimension, but along three dimensions.", "output": {"entities": {}}, "schema": []}
{"input": "Deep tans were induced over the backs of volunteers with repeated exposure to longwave ultraviolet radiation (UV-A).", "output": {"entities": {}}, "schema": []}
{"input": "Elimination of bagassosis in Louisiana paper manufacturing plant workers.", "output": {"entities": {}}, "schema": []}
{"input": "Evaluation of the Du Pont aca ammonia procedure.", "output": {"entities": {}}, "schema": []}
{"input": "2) The time-sharing principle was applied to gain high stability.", "output": {"entities": {}}, "schema": []}
{"input": "In three of the seven, inhalation of 2 ml normal saline produced FEV1 falls of 25% to 30%, but these falls were not as great as each subject' s reactions to the test solutions.", "output": {"entities": {}}, "schema": []}
{"input": "Potency of enflurane in dogs: comparison with halothane and isoflurane.", "output": {"entities": {}}, "schema": []}
{"input": "Measurement of magnesium absorption in man using stable 26Mg as a tracer.", "output": {"entities": {}}, "schema": []}
{"input": "Female mice were significantly more resistant to infection than males.", "output": {"entities": {}}, "schema": []}
{"input": "During the following 9 1/2 years three sequential liver biopsies were performed.", "output": {"entities": {}}, "schema": []}
{"input": "Thromboplastic and fibrynolytic activity of the blood after administration of intralipid in men with history of myocardial infarction up to 45 year of life", "output": {"entities": {}}, "schema": []}
{"input": "The authors report the clinicopathologic findings in four cases of adult women with rhabdomyosarcomas that originated in the endometrium or cervix, or both.", "output": {"entities": {}}, "schema": []}
{"input": "Urine antibodies could not be demonstrated in any other cases.", "output": {"entities": {}}, "schema": []}
{"input": "99mTc phytate, 198Au colloid, and 99mTc antimony sulfide have been used; the last appears to have been the most satisfactory.", "output": {"entities": {}}, "schema": []}
{"input": "A suspected hypothalamic dysfunction and a slightly impaired pituitary function manifested as GH deficiency were their common endocrinological features.", "output": {"entities": {"gene": [{"text": "GH", "start": 94, "end": 96}]}}, "schema": []}
{"input": "A one-way analysis of variance, performed separately for men and women for differences among the three phobic groups on field dependence, showed significance (rho less than. 05) for the females, with the famale agoraphobic being more field dependent than the female simple phobic groups, but not for the males.", "output": {"entities": {}}, "schema": []}
{"input": "Residues removed from transcripts by splicing were identified.", "output": {"entities": {}}, "schema": []}
{"input": "The histochemistry and ultrastructure of calcified cerebellar deposits described by Tonge et al.", "output": {"entities": {}}, "schema": []}
{"input": "A 36 year-old woman was given Ergotamine Tartrate 4. 5 mg p. d. during seven days, after an abortion (a still birth).", "output": {"entities": {}}, "schema": []}
{"input": "As expected, the heparin did produce increased recalcification times and the development of occasional subcutaneous hematomas.", "output": {"entities": {}}, "schema": []}
{"input": "The overall incidence of SIDS was 1. 43 per 1, 000 live births.", "output": {"entities": {}}, "schema": []}
{"input": "Significant increases in mean serum E2 concentration (100 to 150 pg/ml) were noted at 6 and 8 hours after administration on day 1 and at 8 hours on day 4.", "output": {"entities": {}}, "schema": []}
{"input": "We remain convinced that antilymphocyte globulin (ALG) is a potent immunosuppressive agent in humans.", "output": {"entities": {"gene": [{"text": "antilymphocyte globulin", "start": 25, "end": 48}, {"text": "ALG", "start": 50, "end": 53}]}}, "schema": []}
{"input": "Patients were subclassified into age-matched groups of primary untreated cancer (21), recurrent cancer (18), and \" cured \" patients who had been free of disease for at least 9 months (16).", "output": {"entities": {}}, "schema": []}
{"input": "Bacteriostatic and bacteriacidal activity of hydroxy-9 ellipticine in vitro", "output": {"entities": {}}, "schema": []}
{"input": "Personal satisfaction in nursing: an encounter with extremely hostile patients", "output": {"entities": {}}, "schema": []}
{"input": "The effect of hydrostatic pressure on the swimming activity of three hyponeustonic crustacea, Anomalocera patersoni, Pontella mediterranea, Labidocera wollastoni", "output": {"entities": {}}, "schema": []}
{"input": "Abnormal calcium metabolism in normocalcaemic sarcoidosis.", "output": {"entities": {}}, "schema": []}
{"input": "A five-phase experiment was designed to investigate (a) whether contingent music-listening would act as a reinforcer to increase arithmetic performance of EMR children and (b) whether this contingent reinforcement would affect preference for that reinforcer.", "output": {"entities": {}}, "schema": []}
{"input": "The responsiveness of visual cortex (VC) and superior colliculus (SC) was simultaneously compared following conditioning \" ON \" or \" OFF \" stimulation, in the rabbit.", "output": {"entities": {}}, "schema": []}
{"input": "During activity III, one patient developed angina.", "output": {"entities": {}}, "schema": []}
{"input": "Estimation of L-alanine in serum or plasma using the LKB reaction rate analyser.", "output": {"entities": {}}, "schema": []}
{"input": "Infants who died in the first 12 hours from' IVH only' had suffered severe birth asphyxia but in those who died later the main symptom was recurrent apnoea.", "output": {"entities": {}}, "schema": []}
{"input": "Wherever the site of the conditioning stimulation, these modifications disappeared after ischaemia of the leg.", "output": {"entities": {}}, "schema": []}
{"input": "Near term, under experimental conditions, maternal and fetal blood gases, pH, uterine and umbilical blood flows were measured or calculated.", "output": {"entities": {}}, "schema": []}
{"input": "It was concluded that patients with acute respiratory failure requiring artificial ventilation have two componenents of the pulmonary shunt, one parallel with and the other inversely related with the PAO2.", "output": {"entities": {}}, "schema": []}
{"input": "The most common cause of renal deterioration in the spinal cord injured patient is irreversible vesicoureteral reflux.", "output": {"entities": {}}, "schema": []}
{"input": "Circulatory arrest in the operating room.", "output": {"entities": {}}, "schema": []}
{"input": "Iodine-123 was satisfactorily imaged only with the MEC and pinhole collimators, which in turn yielded MTF values comparable to those measured for 99mTc.", "output": {"entities": {}}, "schema": []}
{"input": "Petrous meningioma en plaque presenting as a right middle ear tumor.", "output": {"entities": {}}, "schema": []}
{"input": "The difficulties to analyse prostaglandins (PG) by gas-liquid chromatography are mainly due to the lack of sensitivity of the gas-chromatograph itself (higher than 200 ng) and to the poor resolution of the packed columns.", "output": {"entities": {}}, "schema": []}
{"input": "Also, samples of serum were absorbed with the various solid-phase allergens and the reactivity of the remaining IgE antibodies was determined.", "output": {"entities": {"gene": [{"text": "IgE antibodies", "start": 112, "end": 126}]}}, "schema": []}
{"input": "Extramedullary plasmacytoma of the parotid gland", "output": {"entities": {}}, "schema": []}
{"input": "The recovered calves were tested for immunity to homologous severe challenge, 50 or 73 days after the first infection.", "output": {"entities": {}}, "schema": []}
{"input": "Oxygen tension of the small lymph vessels (PLO2) of the rabbit hind limb was measured with both a flow-through micro chamber and a polarographic catheter-tip oxygen electrode to obtain experimental data on the source of oxygen in the lymph.", "output": {"entities": {}}, "schema": []}
{"input": "I.", "output": {"entities": {}}, "schema": []}
{"input": "Since 1968, a steep decrease in the number of strains resistant to three or more antibiotics (multiple-resistant) and in strains of the 83A complex was noticed.", "output": {"entities": {}}, "schema": []}
{"input": "The contraceptive pattern of 157 women was analysed and 13. 8 percent were using inefficient methods.", "output": {"entities": {}}, "schema": []}
{"input": "I.", "output": {"entities": {}}, "schema": []}
{"input": "Nerve stimulation (1. 5-12 cycles/s) produced frequency-dependent reductions in CBF, a decrease of 50 percent occurring with the highest frequency.", "output": {"entities": {}}, "schema": []}
{"input": "Risk of infection in the treatment of fractures", "output": {"entities": {}}, "schema": []}
{"input": "Prolonged heavy work effected an increase of 10. 3 plus or minus 0. 9 mmHg in in vivo P50 (7. 30 PH-v, 41 degrees C-v, and 45 Pv-CO2); due entirely to the additive effects of increased venous temperature and [H +].", "output": {"entities": {}}, "schema": []}
{"input": "This sequence is almost identical with that of human luteinizing hormone (Sairam, M.", "output": {"entities": {"gene": [{"text": "human luteinizing hormone", "start": 47, "end": 72}]}}, "schema": []}
{"input": "At the very high dose levels used, sodium saccharin and sodium cyclamate were weak solitary carcinogens producing 4/253 and 3/228 bladder tumours respectively, and the first of these tumours did not appear for more than 80 weeks.", "output": {"entities": {}}, "schema": []}
{"input": "However, a 10--15% lengthening of the partial thromboplastin time is evident after 24 hours of storage.", "output": {"entities": {"gene": [{"text": "thromboplastin", "start": 46, "end": 60}]}}, "schema": []}
{"input": "No evidence of either positive or negative chemography was found.", "output": {"entities": {}}, "schema": []}
{"input": "A study of chromosomes of lymphocytes from patients treated with hycanthone.", "output": {"entities": {}}, "schema": []}
{"input": "Study of the physico-chemical state of plutonium-239 in a citrate solution-blood system", "output": {"entities": {}}, "schema": []}
{"input": "Maternal lactation", "output": {"entities": {}}, "schema": []}
{"input": "In both cases, at the end of exposure the same level of blood carboxyhemoglobin (COHb) (about 50%) was reached.", "output": {"entities": {"gene": [{"text": "blood carboxyhemoglobin", "start": 56, "end": 79}, {"text": "COHb", "start": 81, "end": 85}]}}, "schema": []}
{"input": "The results indicate that increased pulmonary blood flow and decreased pulmonary vascular resistance with advancing gestation are due to an increase in the total number of vessels and increased vasomotor reactivity is related to an increase in the total amount of smooth muscle while the thickness of muscle in individual vessels remains constant.", "output": {"entities": {}}, "schema": []}
{"input": "Reduction in dosage restored normal taste sense in all three, but in two the drug had to be discontinued because of persisting high transaminase levels.", "output": {"entities": {}}, "schema": []}
{"input": "A late diagnosis of retinoblastoma is an unquestionable fact that allows its growth and leads to a deterioration in the outlook.", "output": {"entities": {}}, "schema": []}
{"input": "The concept of \" structural identifiability \" is employed in this analysis to determine which model parameters can be and which cannot be determined \" uniquely \" from given input-output data; a step-by-step procedure based on an extension of this concept is presented for adapting the overall approach to the experimental design problem.", "output": {"entities": {}}, "schema": []}
{"input": "Acquired factor VIII inhibitor in non-hemophilic patients", "output": {"entities": {"gene": [{"text": "factor VIII", "start": 9, "end": 20}]}}, "schema": []}
{"input": "The study of calcium metabolism in ten thalassaemic children comperatively with controls after oral administration of 47Ca has shown diminished intestinal absorption.", "output": {"entities": {}}, "schema": []}
{"input": "AP was induced by intraductal infusion of two different concentrations of glycodeoxycholic acid (GDOC 17 mmol and 34 mmol).", "output": {"entities": {}}, "schema": []}
{"input": "Tissue plasminogen activator, its inhibitor and other parameters of fibrinolysis in blood of patients operated for mild hypertrophy of the prostate", "output": {"entities": {"gene": [{"text": "Tissue plasminogen activator", "start": 0, "end": 28}]}}, "schema": []}
{"input": "The mean (+/-SD) PaO2 increased from 80. 8 +/-26. 9 mmHg before to 89. 8 +/-27. 3 mmHg after the infusion (P < 0. 05) and the PaCO2 decreased from 42. 4 +/-8. 3 to 39. 6 +/-7. 9 mmHg (P < 0. 05).", "output": {"entities": {}}, "schema": []}
{"input": "The two drugs increase the rate of early diastolic filling.", "output": {"entities": {}}, "schema": []}
{"input": "We cloned the third human gene for the LD78, termed LD78 gamma and the sequence analysis showed that it is a 5'-truncated pseudogene.", "output": {"entities": {"gene": [{"text": "LD78", "start": 39, "end": 43}, {"text": "LD78 gamma", "start": 52, "end": 62}]}}, "schema": []}
{"input": "In the absence of histological criteria, which it is difficult to demand in view of the variability of results and potential dangers of endomyocardial biopsy involving such thin and fragile ventricular walls, the diagnosis of ACRV is based upon the concomitant existence of: (1) electrophysiological criteria: ventricular arrhythmias, in particular sustained monomorphous VT, with the particular feature of a very high degree of sensitivity to adrenergic stimulation (exercise), the existence of late potentials on the high amplification ECG, a highly specific sign, though unfortunately of poor sensitivity in localized froms, those which are most difficult to identify (2); segmentary morphological and kinetic RV abnormalities, most often resulting in localized akinetic or dyskinetic parietal vaulting, with stasis \" in situ \".", "output": {"entities": {}}, "schema": []}
{"input": "66: 469-479, 1992).", "output": {"entities": {}}, "schema": []}
{"input": "Possibly, the scr1-1 mutation does not affect signal recognition or translational arrest but instead results in maintenance of translational arrest of AEP synthesis.", "output": {"entities": {"gene": [{"text": "scr1-1 mutation", "start": 14, "end": 29}, {"text": "AEP", "start": 151, "end": 154}]}}, "schema": []}
{"input": "Both Rep78 and Rep68 cut the terminal AAV sequence at the same site (nucleotide 124).", "output": {"entities": {"gene": [{"text": "Rep78", "start": 5, "end": 10}, {"text": "Rep68", "start": 15, "end": 20}]}}, "schema": []}
{"input": "Nucleotide sequence analysis revealed that TAR-binding protein is very similar to the CREB2 protein.", "output": {"entities": {"gene": [{"text": "TAR-binding protein", "start": 43, "end": 62}, {"text": "CREB2 protein", "start": 86, "end": 99}]}}, "schema": []}
{"input": "A patient suffering from heparin-associated thrombocytopenia (HAT), recurrent arteriothromboses, and acute renal failure after treatment with standard heparin is described.", "output": {"entities": {}}, "schema": []}
{"input": "Comparison with the sequence databanks show that Tactile is a member of the immunoglobulin gene superfamily, with similarity to Drosophila amalgam, the melanoma Ag MUC-18, members of the carcinoembryonic Ag family, the poliovirus receptor, and the neural cell adhesion molecule.", "output": {"entities": {"gene": [{"text": "Tactile", "start": 49, "end": 56}, {"text": "immunoglobulin gene superfamily", "start": 76, "end": 107}, {"text": "Drosophila amalgam", "start": 128, "end": 146}, {"text": "melanoma Ag MUC-18", "start": 152, "end": 170}, {"text": "carcinoembryonic Ag family", "start": 187, "end": 213}, {"text": "poliovirus receptor", "start": 219, "end": 238}, {"text": "neural cell adhesion molecule", "start": 248, "end": 277}]}}, "schema": []}
{"input": "The phenotypes of the ICP0 nonsense mutants were intermediate between those of the wild-type virus and 7134 in that the more ICP0-coding sequence expressed by a given nonsense mutant, the more wild type-like was its phenotype.", "output": {"entities": {"gene": [{"text": "ICP0", "start": 22, "end": 26}, {"text": "ICP0-coding sequence", "start": 125, "end": 145}]}}, "schema": []}
{"input": "In contrast, gel mobility shift experiments have failed to reveal that HAP2 or HAP3 binds to domain 1 or that hap3 mutations affect the complexes bound to it.", "output": {"entities": {"gene": [{"text": "HAP2", "start": 71, "end": 75}, {"text": "HAP3", "start": 79, "end": 83}, {"text": "hap3", "start": 110, "end": 114}]}}, "schema": []}
{"input": "The experiment results showed: (i) not only 1O2, but also free radicals (O2-.. OH and YHPD-.) can be formed by the aid of YHPD; and (ii) as to the ability of producing 1O2, YHPD less than BHPD, while for generating O2-. and. OH, YHPD greater than BHPD.", "output": {"entities": {}}, "schema": []}
{"input": "Two points are indicated: first, the photosensitized damage of YHPD is interrelated to not only 1O2, but also free radicals (O2-.. OH and YHPD-.); second, although the photosensitized damage of YHPD is stronger than that of BHPD, yet the photosensitized damage is negatively correlated to the yield of 1O2 but positively correlated to those of O2-. and OH.", "output": {"entities": {}}, "schema": []}
{"input": "The unphosphorylated form of RNA polymerase II is designated IIA, whereas the phosphorylated form is designated IIO.", "output": {"entities": {"gene": [{"text": "RNA polymerase II", "start": 29, "end": 46}]}}, "schema": []}
{"input": "RNA polymerase IIA was recovered in transcriptionally active complexes in reactions in which the input enzyme was RNA polymerase IIA.", "output": {"entities": {"gene": [{"text": "RNA polymerase IIA", "start": 0, "end": 18}, {"text": "RNA polymerase IIA", "start": 114, "end": 132}]}}, "schema": []}
{"input": "Fructokinase activity is elevated up to twofold when Z. mobilis was grown on fructose instead of glucose, and there was a parallel increase in frk mRNA levels.", "output": {"entities": {"gene": [{"text": "Fructokinase", "start": 0, "end": 12}, {"text": "frk mRNA", "start": 143, "end": 151}]}}, "schema": []}
{"input": "The enhancer region of Akv murine leukemia virus contains the sequence motif ACAGATGG.", "output": {"entities": {}}, "schema": []}
{"input": "Two splice variants of ALF1 cDNA have been found, differing by a 72-bp insertion, coding for putative proteins of 682 and 706 amino acids.", "output": {"entities": {"gene": [{"text": "ALF1 cDNA", "start": 23, "end": 32}]}}, "schema": []}
{"input": "Cloning and primary structure of neurocan, a developmentally regulated, aggregating chondroitin sulfate proteoglycan of brain.", "output": {"entities": {}}, "schema": []}
{"input": "The-64/-37 region interacted with purified Sp1 and an unidentified protein (s), proximal regulatory factor (s) I (PRF-I).", "output": {"entities": {"gene": [{"text": "Sp1", "start": 43, "end": 46}, {"text": "proximal regulatory factor (s) I", "start": 80, "end": 112}, {"text": "PRF-I", "start": 114, "end": 119}]}}, "schema": []}
{"input": "This soluble form of the HGFr (sHGFr) bound HGF with an affinity similar to that of the authentic, membrane-associated receptor.", "output": {"entities": {"gene": [{"text": "HGFr", "start": 25, "end": 29}, {"text": "sHGFr", "start": 31, "end": 36}, {"text": "HGF", "start": 44, "end": 47}]}}, "schema": []}
{"input": "Also, the human glycoprotein alpha-subunit promoter was induced 10-fold by FSK in GH4 rat pituitary cells. (ABSTRACT TRUNCATED AT 400 WORDS)", "output": {"entities": {"gene": [{"text": "human glycoprotein alpha-subunit promoter", "start": 10, "end": 51}, {"text": "FSK", "start": 75, "end": 78}]}}, "schema": []}
{"input": "Some research studies have related this kind of tumors with prolonged ingestion of H2 inhibitors and others antacid.", "output": {"entities": {}}, "schema": []}
{"input": "The rationale for continuous dopaminergic stimulation in patients with Parkinson' s disease.", "output": {"entities": {}}, "schema": []}
{"input": "Amino acid sequence comparison revealed significant homology between the yeast and Escherichia coli gamma-glutamyl kinases throughout their lengths.", "output": {"entities": {"gene": [{"text": "yeast and Escherichia coli gamma-glutamyl kinases", "start": 73, "end": 122}]}}, "schema": []}
{"input": "This computation is performed by a parallel network of locally connected neuron-like elements.", "output": {"entities": {}}, "schema": []}
{"input": "Neither gene possesses a distinct transcriptional start site as shown by nuclease S1 analysis.", "output": {"entities": {"gene": [{"text": "nuclease S1", "start": 73, "end": 84}]}}, "schema": []}
{"input": "Gene and pseudogene of the mouse cation-dependent mannose 6-phosphate receptor.", "output": {"entities": {"gene": [{"text": "mannose 6-phosphate receptor", "start": 50, "end": 78}]}}, "schema": []}
{"input": "The chick axon-associated surface glycoprotein neurofascin is implicated in axonal growth and fasciculation as revealed by antibody perturbation experiments.", "output": {"entities": {"gene": [{"text": "neurofascin", "start": 47, "end": 58}]}}, "schema": []}
{"input": "Entry of yeast cells into the mitotic cell cycle (Start) involves a form of the CDC28 kinase that associates with G1-specific cyclins encoded by CLN1 and CLN2 (ref.", "output": {"entities": {"gene": [{"text": "CDC28 kinase", "start": 80, "end": 92}, {"text": "cyclins", "start": 126, "end": 133}, {"text": "CLN1", "start": 145, "end": 149}, {"text": "CLN2", "start": 154, "end": 158}]}}, "schema": []}
{"input": "From all clinically important yeasts species, a total of 96% were identified by ATB method according to conventional methods.", "output": {"entities": {}}, "schema": []}
{"input": "Consequently, significant differences between the measured and calculated methods were noted in oxygen uptake (213 +/-41 ml/min vs 193 +/-25 ml/min, p < 0. 001), oxygen delivery (780 +/-297 ml/min vs 716 +/-296 ml/min, p < 0. 001), and cardiac output (5. 8 +/-2. 2 L/min vs 5. 3 +/-1. 8 L/min, p < 0. 001).", "output": {"entities": {}}, "schema": []}
{"input": "Negatively supercoiled plasmid pUC19 did not compete, whereas an otherwise identical plasmid pUC19 (CG), which contained a (dG-dC) 7 segment in the Z-form was an excellent competitor.", "output": {"entities": {}}, "schema": []}
{"input": "In contrast, the lumenal domains of Sec12p, Stl1p and Stl2p are very different in size and do not show any appreciable homology.", "output": {"entities": {"gene": [{"text": "Sec12p", "start": 36, "end": 42}, {"text": "Stl1p", "start": 44, "end": 49}, {"text": "Stl2p", "start": 54, "end": 59}]}}, "schema": []}
{"input": "The gene sequence also identified a 340-nucleotide RNA in total yeast RNA and in purified RNase MRP enzyme preparations.", "output": {"entities": {"gene": [{"text": "RNase MRP enzyme", "start": 90, "end": 106}]}}, "schema": []}
{"input": "The RNase MRP RNA gene was deleted by insertional replacement and found to be essential for cellular viability, indicating a critical nuclear role for RNase MRP.", "output": {"entities": {"gene": [{"text": "RNase MRP RNA gene", "start": 4, "end": 22}, {"text": "RNase MRP", "start": 151, "end": 160}]}}, "schema": []}
{"input": "Mutational analysis of essential IncP alpha plasmid transfer genes traF and traG and involvement of traF in phage sensitivity.", "output": {"entities": {"gene": [{"text": "traF", "start": 67, "end": 71}, {"text": "traG", "start": 76, "end": 80}, {"text": "traF", "start": 100, "end": 104}]}}, "schema": []}
{"input": "The promoter was stimulated 8-20-fold by phorbol esters accounting for the previously observed transcriptional activation of protein kinase C beta.", "output": {"entities": {"gene": [{"text": "protein kinase C beta", "start": 125, "end": 146}]}}, "schema": []}
{"input": "In the eight patients with persistent generalized lymph-adenopathy (PGL) and nontender, nonenlarging nodes, pathologic analysis revealed lymphoid hyperplasia.", "output": {"entities": {}}, "schema": []}
{"input": "We found that both the E26 virus-encoded v-ets and the myeloid/B-cell-specific factor PU. 1 bind efficiently to this site in vitro.", "output": {"entities": {"gene": [{"text": "v-ets", "start": 41, "end": 46}, {"text": "myeloid/B-cell-specific factor PU. 1", "start": 55, "end": 91}]}}, "schema": []}
{"input": "Localization of the brachial plexus with the nerve stimulator is equally effective at the interscalene, supraclavicular, and axillary sites.", "output": {"entities": {}}, "schema": []}
{"input": "The second method, the \" macro \" assay, has a sensitivity range of 0. 03-5. 0 micrograms phosphorus with 100-500 microliters HClO4.", "output": {"entities": {}}, "schema": []}
{"input": "Anti-CRK antibodies detect a 53kDa protein in extracts of C. fasciculata in agreement with the size predicted from the nucleotide sequence of the cloned gene.", "output": {"entities": {"gene": [{"text": "Anti-CRK antibodies", "start": 0, "end": 19}]}}, "schema": []}
{"input": "Use of free-access minerals.", "output": {"entities": {}}, "schema": []}
{"input": "Respiratory interaction after spinal anesthesia and sedation with midazolam.", "output": {"entities": {}}, "schema": []}
{"input": "V.", "output": {"entities": {}}, "schema": []}
{"input": "Rice dwarf phytoreovirus segment S12 transcript is tricistronic in vitro.", "output": {"entities": {"gene": [{"text": "Rice dwarf phytoreovirus segment S12 transcript", "start": 0, "end": 47}]}}, "schema": []}
{"input": "Cold cardioplegia was administered at 45 mm Hg every 20 minutes for 2 hours.", "output": {"entities": {}}, "schema": []}
{"input": "Comparable amounts of alpha 5 beta 1 integrin were isolated from these cells by chromatography of detergent extracts on a fibronectin cell-binding fragment affinity column and elution with EDTA.", "output": {"entities": {"gene": [{"text": "alpha 5 beta 1 integrin", "start": 22, "end": 45}, {"text": "fibronectin", "start": 122, "end": 133}]}}, "schema": []}
{"input": "From this library, LEU2 and HIS3 cDNAs were recovered at a frequency of about 1 in 10 (4) and in 12 out of 13 cases these were expressed in a galactose-dependent manner.", "output": {"entities": {"gene": [{"text": "LEU2", "start": 19, "end": 23}, {"text": "HIS3", "start": 28, "end": 32}]}}, "schema": []}
{"input": "Among these, ACT1 was isolated four times, and NSR1 three times.", "output": {"entities": {"gene": [{"text": "ACT1", "start": 13, "end": 17}, {"text": "NSR1", "start": 47, "end": 51}]}}, "schema": []}
{"input": "BiP670 retains basal and Ca2 + ionophore A23187-inducible activities.", "output": {"entities": {"gene": [{"text": "BiP670", "start": 0, "end": 6}]}}, "schema": []}
{"input": "As a part of a large examination, total and free serum cholesterol, total lipid and triglyceride levels were determined.", "output": {"entities": {}}, "schema": []}
{"input": "DIBA was more sensitive and had a better negative predictive value and a lower false negative percentage than DFAT.", "output": {"entities": {}}, "schema": []}
{"input": "Caries and parodontitis have been one of the most spread diseases of mankind.", "output": {"entities": {}}, "schema": []}
{"input": "ME1a1, a 16-base-pair nuclear factor binding site residing between the c-MYC P1 and P2 transcription initiation sites, is required for P2 activity.", "output": {"entities": {"gene": [{"text": "ME1a1", "start": 0, "end": 5}, {"text": "c-MYC P1 and P2 transcription initiation sites", "start": 71, "end": 117}]}}, "schema": []}
{"input": "The next twenty years of prevention in Indian country: visionary, complex, and practical.", "output": {"entities": {}}, "schema": []}
{"input": "The cDNA has an open reading frame of 900 amino acids capable of encoding a 97-kDa protein.", "output": {"entities": {}}, "schema": []}
{"input": "The gene encoding TRP-2 maps to mouse chromosome 14, in the region of the coat colour mutation slaty.", "output": {"entities": {"gene": [{"text": "TRP-2", "start": 18, "end": 23}, {"text": "coat colour mutation slaty", "start": 74, "end": 100}]}}, "schema": []}
{"input": "A comparison of the amino acid sequence of the T. thermophilus enzyme with that of the Escherichia coli enzyme showed (i) a 37% overall similarity; (ii) the conservation of the Ser residue, which is known to be phosphorylated in the E. coli enzyme, and of the surrounding sequence; and (iii) the presence of 141 extra residues at the C terminus of the T. thermophilus enzyme.", "output": {"entities": {}}, "schema": []}
{"input": "Because single-chamber rate-adaptive atrial pacing leaves the patient exposed to the risk of future development of AV block and DDD pacing does not provide chronotropic support, it is likely that the new rate-adaptive dual-chamber (DDDR) devices will be used in a significant number of these patients. (ABSTRACT TRUNCATED AT 250 WORDS)", "output": {"entities": {}}, "schema": []}
{"input": "When transiently transfected into K562 cells, this Lg genomic clone is actively transcribed, suggesting that, although it possesses the characteristics of a processed pseudogene, it is likely to correspond to the gene encoding this new ferritin subunit.", "output": {"entities": {"gene": [{"text": "Lg", "start": 51, "end": 53}, {"text": "ferritin subunit", "start": 236, "end": 252}]}}, "schema": []}
{"input": "The p130 and p62 tyrosine-phosphorylated proteins that complexed v-Src SH2 in vitro also associated with v-Src in v-src-transformed Rat-2 cells; this in vivo binding was dependent on the v-Src SH2 domain.", "output": {"entities": {"gene": [{"text": "p130", "start": 4, "end": 8}, {"text": "p62", "start": 13, "end": 16}, {"text": "v-Src SH2", "start": 65, "end": 74}, {"text": "v-Src", "start": 105, "end": 110}, {"text": "v-src", "start": 114, "end": 119}, {"text": "v-Src SH2", "start": 187, "end": 196}]}}, "schema": []}
{"input": "These data support a possible biological significance of the frameshift to occur at this position of the large overlap by including the putative RNA template-binding site of the PLRV replicase in the ORF2a/ORF2b transframe protein.", "output": {"entities": {"gene": [{"text": "PLRV replicase", "start": 178, "end": 192}, {"text": "ORF2a/ORF2b transframe protein", "start": 200, "end": 230}]}}, "schema": []}
{"input": "The MET4 gene was cloned, and its sequence reveals that it encodes a protein related to the family of the bZIP transcriptional activators.", "output": {"entities": {"gene": [{"text": "MET4", "start": 4, "end": 8}, {"text": "bZIP transcriptional activators", "start": 106, "end": 137}]}}, "schema": []}
{"input": "It is believed that these domains are important for directing specific protein-protein interactions necessary for the proper functioning of Src.", "output": {"entities": {"gene": [{"text": "Src", "start": 140, "end": 143}]}}, "schema": []}
{"input": "The recently developed gamma-interferon (IFN-gamma) assay system for the diagnosis of bovine tuberculosis in cattle has been accredited by the Standing Committee on Agriculture for use in Australia.", "output": {"entities": {"gene": [{"text": "gamma-interferon", "start": 23, "end": 39}, {"text": "IFN-gamma", "start": 41, "end": 50}]}}, "schema": []}
{"input": "Control Tmuscle was 35. 8 +/-0. 7 degrees C, with control Wi, max being 51. 6 (SD 8. 7) W. kg-1.", "output": {"entities": {}}, "schema": []}
{"input": "However, other regions of the plasmid are also efficiently repaired.", "output": {"entities": {}}, "schema": []}
{"input": "Thus, the human D1A gene belongs to the category of tissue-specific, regulated genes that have housekeeping-type promoters.", "output": {"entities": {"gene": [{"text": "human D1A gene", "start": 10, "end": 24}]}}, "schema": []}
{"input": "Computer-aided \" FRAME \" analysis revealed four possible open reading frames (ORFs), three in one direction and one in the opposite direction.", "output": {"entities": {}}, "schema": []}
{"input": "Domain II is highly homologous to the LDL receptor and contains four repeats with perfect conservation of all 6 consecutive cysteines.", "output": {"entities": {"gene": [{"text": "LDL receptor", "start": 38, "end": 50}]}}, "schema": []}
{"input": "Here, we present evidence for a model in which mRNA sequences up to around 100 nucleotides downstream from the start codon of 21K fold back and base-pair to the 21K translation initiation region, thereby decreasing the translation initiation frequency.", "output": {"entities": {}}, "schema": []}
{"input": "In the last 20 years, the therapeutic uses of botulinum toxin, a potent neurotoxin, have been investigated.", "output": {"entities": {"gene": [{"text": "botulinum toxin", "start": 46, "end": 61}]}}, "schema": []}
{"input": "At the C-terminus of the protein is a domain that contains sequences very similar to those found in the breakpoint cluster region gene product, n-chimerin, and rho GAP, all of which have been shown to possess intrinsic GAP activity on small GTPases.", "output": {"entities": {"gene": [{"text": "n-chimerin", "start": 144, "end": 154}, {"text": "rho GAP", "start": 160, "end": 167}, {"text": "GAP", "start": 219, "end": 222}, {"text": "small GTPases", "start": 235, "end": 248}]}}, "schema": []}
{"input": "The circadian rhythmicity of sleep was pronounced.", "output": {"entities": {}}, "schema": []}
{"input": "The sequence data now permit a detailed interpretation of the X-ray crystallographic structure of the enzyme and the cloning and expression of the clostridial gene will facilitate site-directed mutagenesis.", "output": {"entities": {}}, "schema": []}
{"input": "AgMNPV and Orgyia pseudotsugata MNPV (OpMNPV) are similar in terms of promoter structure and polyhedrin primary sequence, and the polyhedrin gene of both viruses is transcribed in the anti-clockwise direction in relation to their physical maps.", "output": {"entities": {"gene": [{"text": "polyhedrin primary sequence", "start": 93, "end": 120}, {"text": "polyhedrin gene", "start": 130, "end": 145}]}}, "schema": []}
{"input": "These results are consistent with the roles that CCK and trypsin inhibitors are believed to play in the negative feedback control of pancreatic exocrine function.", "output": {"entities": {"gene": [{"text": "CCK", "start": 49, "end": 52}, {"text": "trypsin", "start": 57, "end": 64}]}}, "schema": []}
{"input": "A 724-bp segment of the 5'-flanking region consisting of the proximal E-box flanked upstream by a mammalian-specific 352-bp region was sufficient for maximal transcriptional activation in postconfluent BC3H1 myoblasts.", "output": {"entities": {}}, "schema": []}
{"input": "These results indicate that baculovirus-expressed TR mediates transcriptional activation and repression in a promoter-specific manner in vitro.", "output": {"entities": {"gene": [{"text": "TR", "start": 50, "end": 52}]}}, "schema": []}
{"input": "The serum erythropoietin (EPO) concentrations of 15 male triathletes (26. 3 U. ml-1) were significantly lower than those of 45 male distance runners (31. 6 U. ml-1; P less than 0. 05).", "output": {"entities": {"gene": [{"text": "erythropoietin", "start": 10, "end": 24}, {"text": "EPO", "start": 26, "end": 29}]}}, "schema": []}
{"input": "These results support the diagnostic validity of NFPD in CP/NCA patients, because such patients had a family history of panic disorder similar to patients with a more classical panic disorder presentation.", "output": {"entities": {}}, "schema": []}
{"input": "FDA regulations for growth factors and related products.", "output": {"entities": {}}, "schema": []}
{"input": "DESIGN: Serum aldosterone and plasma renin activity were measured supine prior to and 60, 90, 120 minutes after oral captopril, 25 mg.", "output": {"entities": {"gene": [{"text": "plasma renin", "start": 30, "end": 42}]}}, "schema": []}
{"input": "Both parents are clinically normal and unrelated.", "output": {"entities": {}}, "schema": []}
{"input": "UF-021 ophthalmic solution (0. 03 to 0. 24%), when topically applied to the eyes of rabbits, caused dose-dependent IOP reduction (2. 8 to 5. 2 mmHg), without transient IOP rise.", "output": {"entities": {}}, "schema": []}
{"input": "This is in contrast with the classical' oxygen debt hypothesis', which states that the oxygen debt and lactate clearance are linked.", "output": {"entities": {}}, "schema": []}
{"input": "In addition a greater proportion of women in the sweeping group had a cervical dilatation of 4 cm or more at the first vaginal examination in the labour ward (16/33 (49%) vs 5/32 (16%); OR 4. 39; 95% CI 1. 56 to 12. 32; P = 0. 005).", "output": {"entities": {}}, "schema": []}
{"input": "A control group of nine women (age 23-40 years) on oral contraceptives (Nordette-28) was also studied four times during a pill cycle.", "output": {"entities": {}}, "schema": []}
{"input": "Patients with an enzymatic activity below X--1 manifested a decrease of the content of IgA, IgG, IgM, T and B lymphocytes, and of phagocytic activity of neutrophils as compared to patients exhibiting a high enzymatic activity.", "output": {"entities": {"gene": [{"text": "IgA", "start": 87, "end": 90}, {"text": "IgG", "start": 92, "end": 95}, {"text": "IgM", "start": 97, "end": 100}]}}, "schema": []}
{"input": "The relation between myocardial beta-adrenergic receptor and left ventricular (LV) function was studied in 10 patients, aged 41 to 61 years (average 51), with LV volume overload mainly due to chronic mitral regurgitation.", "output": {"entities": {"gene": [{"text": "myocardial beta-adrenergic receptor", "start": 21, "end": 56}]}}, "schema": []}
{"input": "axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase.", "output": {"entities": {"gene": [{"text": "receptor tyrosine kinase", "start": 93, "end": 117}]}}, "schema": []}
{"input": "The single most important element, by linker-scanning analysis, is a 10-bp region that contains a CCAAT motif.", "output": {"entities": {}}, "schema": []}
{"input": "Capnography curves of 40 HVS patients, 40 non-HVS patients with psycho-somatic complaints and 26 healthy controls were analyzed.", "output": {"entities": {}}, "schema": []}
{"input": "However, alterations in electrostatic and hydrophobic interactions created by the three amino acid substitutions prevent the conformational change in the enzyme usually produced by calmodulin binding.", "output": {"entities": {"gene": [{"text": "calmodulin", "start": 181, "end": 191}]}}, "schema": []}
{"input": "Transfer RNA genes from Dictyostelium discoideum are frequently associated with repetitive elements and contain consensus boxes in their 5' and 3'-flanking regions.", "output": {"entities": {}}, "schema": []}
{"input": "Histamine-2 blockade in psoriasis", "output": {"entities": {}}, "schema": []}
{"input": "A third is a partial element terminating at a probable internal restriction site used for cloning.", "output": {"entities": {}}, "schema": []}
{"input": "No such benefits were seen for children with CD4 + counts below 0. 2 x 10 (9) per liter at entry.", "output": {"entities": {"gene": [{"text": "CD4 +", "start": 45, "end": 50}]}}, "schema": []}
{"input": "Because the human Antp TATAA binding protein is expressed in both lymphoid and non-lymphoid cells, we suggest that this homeobox gene has evolved a more general transcriptional regulatory function in higher eukaryotic cells.", "output": {"entities": {"gene": [{"text": "human Antp TATAA binding protein", "start": 12, "end": 44}, {"text": "homeobox gene", "start": 120, "end": 133}]}}, "schema": []}
{"input": "Venkatesan, and D.", "output": {"entities": {}}, "schema": []}
{"input": "Stable expression of the chimeric alpha i (54)/s polypeptide in Chinese hamster ovary (CHO) cells constitutively increased both cAMP synthesis and cAMP-dependent protein kinase activity.", "output": {"entities": {"gene": [{"text": "alpha i (54)/s", "start": 34, "end": 48}, {"text": "cAMP-dependent protein kinase", "start": 147, "end": 176}]}}, "schema": []}
{"input": "Surprisingly, there is no sequence homology between this region of Ly-6E and the established consensus for the interferon-stimulated response element, which has been shown functionally important to all previously characterized alpha/beta interferon-inducible promoters.", "output": {"entities": {"gene": [{"text": "Ly-6E", "start": 67, "end": 72}, {"text": "interferon-stimulated response element", "start": 111, "end": 149}, {"text": "alpha/beta interferon", "start": 227, "end": 248}]}}, "schema": []}
{"input": "Relatively large DNA rearrangements spanning the region with tandem direct repeats encoding the carboxy-terminal histone H1-like structure of AlgP were detected in several strains upon conversion from the mucoid to the nonmucoid phenotype.", "output": {"entities": {"gene": [{"text": "histone H1-like", "start": 113, "end": 128}, {"text": "AlgP", "start": 142, "end": 146}]}}, "schema": []}
{"input": "It is, however, extremely homologous to a third' non-classical' gene, HLA-5. 4, and to the chimpanzee gene, Ch28.", "output": {"entities": {"gene": [{"text": "HLA-5. 4", "start": 70, "end": 78}, {"text": "Ch28", "start": 108, "end": 112}]}}, "schema": []}
{"input": "Although the N13-N20 interpeak interval remained stable because of the parallel shift of the 2 peaks, the central conduction time measured from onset latencies of N11 and N20 significantly increased.", "output": {"entities": {}}, "schema": []}
{"input": "Isolation and characterization of the rat chromosomal gene for a polypeptide (pS1) antigenically related to statin.", "output": {"entities": {"gene": [{"text": "pS1", "start": 78, "end": 81}, {"text": "statin", "start": 108, "end": 114}]}}, "schema": []}
{"input": "Chem.", "output": {"entities": {}}, "schema": []}
{"input": "This report substantiates that at least two of the 18 kDa hsps in maize are products of different but related genes.", "output": {"entities": {"gene": [{"text": "hsps", "start": 58, "end": 62}]}}, "schema": []}
{"input": "Finally, some point mutations in the Gag-Pol PR domain inhibited activation of RT in trans by a wild-type PR, suggesting that the correct conformation of the PR domain in Gag-Pol is prerequisite for activation of RT.", "output": {"entities": {"gene": [{"text": "Gag", "start": 37, "end": 40}, {"text": "Pol", "start": 41, "end": 44}, {"text": "RT", "start": 79, "end": 81}, {"text": "PR", "start": 106, "end": 108}, {"text": "PR", "start": 158, "end": 160}, {"text": "Gag", "start": 171, "end": 174}, {"text": "Pol", "start": 175, "end": 178}, {"text": "RT", "start": 213, "end": 215}]}}, "schema": []}
{"input": "Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation.", "output": {"entities": {"gene": [{"text": "CDC2-related kinase", "start": 35, "end": 54}, {"text": "budding yeast cdc28", "start": 79, "end": 98}]}}, "schema": []}
{"input": "E., Hession, C., Goff, D., Griffiths, B., Tizard, R., Newman, B., Chi-Rosso, G., and Lobb, R., (1990) Cell 63, 1349-1356).", "output": {"entities": {}}, "schema": []}
{"input": "The above results mean that the increase in alpha-adrenergic receptors makes the prostate, which has been already hypertrophied, less elastic, inhibiting external urinary sphincter function.", "output": {"entities": {"gene": [{"text": "alpha-adrenergic receptors", "start": 44, "end": 70}]}}, "schema": []}
{"input": "An approximately 2-kilobase B2 transcript was expressed in all alfalfa organs tested.", "output": {"entities": {"gene": [{"text": "2-kilobase B2 transcript", "start": 17, "end": 41}]}}, "schema": []}
{"input": "In some early B cells and Abelson murine leukemia virus-transformed pre-B-cell lines, LT mRNA is constitutively expressed.", "output": {"entities": {"gene": [{"text": "LT mRNA", "start": 86, "end": 93}]}}, "schema": []}
{"input": "Testosterone, free testosterone, non-sex hormone-binding globulin-bound testosterone, and free androgen index: which testosterone measurement is most relevant to reproductive and sexual function in men with epilepsy?", "output": {"entities": {"gene": [{"text": "non-sex hormone-binding globulin", "start": 33, "end": 65}]}}, "schema": []}
{"input": "One patients had plasma C-peptide greater than 3 pM and was therefore excluded from analysis.", "output": {"entities": {"gene": [{"text": "plasma C-peptide", "start": 17, "end": 33}]}}, "schema": []}
{"input": "Complex repetitive discharges were observed in muscles of mdx mice but no complex repetitive discharges or other abnormalities were observed in muscles of normal control mice.", "output": {"entities": {}}, "schema": []}
{"input": "W. G.", "output": {"entities": {}}, "schema": []}
{"input": "A mouse brain beta-spectrin of cDNA was identified within a lambda Gt11 expression library using an antibody which specifically binds with the 235 kDa spectrin beta-subunit.", "output": {"entities": {"gene": [{"text": "mouse brain beta-spectrin", "start": 2, "end": 27}, {"text": "235 kDa spectrin beta-subunit", "start": 143, "end": 172}]}}, "schema": []}
{"input": "We obtained quantitative evidence on the coding of interaural time differences (ITDs) of click stimuli by 40 single neurons in the auditory cortex of anesthetized albino rats.", "output": {"entities": {}}, "schema": []}
{"input": "Pulmonary hypertension, with or without coronary arterial narrowing, is the major condition leading to isolated atrial infarction.", "output": {"entities": {}}, "schema": []}
{"input": "Diltiazem decreased the total body clearance from 34. 0 +/-8. 0 to 28. 6 +/-6. 1 mL/min (P less than. 01), and prolonged the elimination half-life from 12. 6 +/-3. 0 to 14. 3 +/-2. 5 hours (P less than. 01) of antipyrine without any changes in volume of distribution.", "output": {"entities": {}}, "schema": []}
{"input": "The model is able to anticipate why the effect of water fluoridation on caries prevalence is most pronounced when caries is diagnosed at cavity level.", "output": {"entities": {}}, "schema": []}
{"input": "An 8-h exposure to 10 mg DMEA/m3 corresponds to a postexposure plasma concentration and 2-h postexposure urinary excretion of 4. 9 mumol/l and 75 mmol/mol creatinine, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "Marked thrombocytopenia, depletion of serum fibrinogen and prolonged prothrombin and activated partial thromboplastin time, were recorded at 5 to 10 and 30 to 40 minutes after intravenous envenomation.", "output": {"entities": {"gene": [{"text": "serum fibrinogen", "start": 38, "end": 54}, {"text": "prothrombin", "start": 69, "end": 80}, {"text": "thromboplastin", "start": 103, "end": 117}]}}, "schema": []}
{"input": "Auditory threshold shifts, as measured by the auditory evoked brainstem response, were measured at 2, 4, 8, 12, 16, 20 and 24 kHz.", "output": {"entities": {}}, "schema": []}
{"input": "Interspecific backcross analysis using progeny derived from matings of (C57BL/6J x Mus spretus) F1 x C57BL/6J mice indicates that the thrombospondin gene is tightly linked to the Fshb, Actcl, Ltk, and B2M loci on murine chromosome 2.", "output": {"entities": {"gene": [{"text": "thrombospondin gene", "start": 134, "end": 153}, {"text": "Fshb", "start": 179, "end": 183}, {"text": "Actcl", "start": 185, "end": 190}, {"text": "Ltk", "start": 192, "end": 195}, {"text": "B2M loci", "start": 201, "end": 209}]}}, "schema": []}
{"input": "If delay has occurred between centrifugation and the measurement, causing substantial loss of CO2, equilibration of the sample with a gas mixture corresponding to PCO2 = 5. 3 kPa prior to the measurement is recommended.", "output": {"entities": {}}, "schema": []}
{"input": "The EPO levels were distinctly increased before transfusion; they did not significantly change just after transfusion, but subsequently decreased.", "output": {"entities": {"gene": [{"text": "EPO", "start": 4, "end": 7}]}}, "schema": []}
{"input": "Felodipine did not alter the baseline FEV1, but showed a small significant inhibitory effect upon histamine and AMP induced bronchoconstriction.", "output": {"entities": {}}, "schema": []}
{"input": "Relatively little is known regarding the role of 5-HT2 receptor activity in male rat sexual behavior.", "output": {"entities": {"gene": [{"text": "5-HT2 receptor", "start": 49, "end": 63}]}}, "schema": []}
{"input": "The present study reports visual evoked potential responses to pattern reversal (VEP-P) in ten third trimester pregnant women and changes in latency of NPN complex when compared with these responses in the non pregnant state.", "output": {"entities": {}}, "schema": []}
{"input": "In all instances the apparent alcohol responses were very small and never exceeded a reading of 1 microgram/100ml for breath samples more than 10min post-exposure.", "output": {"entities": {}}, "schema": []}
{"input": "The gene is 1, 139 base pairs (bp) long, and, like other members of the SIG family, the beta TG gene is divided into 3 exons.", "output": {"entities": {"gene": [{"text": "SIG family", "start": 72, "end": 82}, {"text": "beta TG gene", "start": 88, "end": 100}]}}, "schema": []}
{"input": "Thus, the positive effect of NS1 on the steady-state levels of P4 transcripts depends on the amplification of gene copy number and the integrity of the terminal repeats.", "output": {"entities": {"gene": [{"text": "NS1", "start": 29, "end": 32}, {"text": "P4 transcripts", "start": 63, "end": 77}]}}, "schema": []}
{"input": "It is transparent, cheap to be made, and easy to empty and was tested in 118 animals for two and four weeks.", "output": {"entities": {}}, "schema": []}
{"input": "The Thr161Val mutation causes a lethal phenotype in the fission yeast Schizosaccharomyces pombe, while replacement of Thr161 with glutamic acid, potentially mimicking phosphorylation, causes uncoordination of mitosis and multiple cytokinesis.", "output": {"entities": {}}, "schema": []}
{"input": "Deregulation of their expression may contribute to malignant transformation associated with HTLV-1 infection.", "output": {"entities": {}}, "schema": []}
{"input": "In conclusion, we observed a great regeneration ability following mechanical injury in the nasal mucosa.", "output": {"entities": {}}, "schema": []}
{"input": "There occurred a linear relationship between the drop in glucose-6-phosphatase dehydrogenase activity and in vitamin E level, on one hand, and the duration of poisoning with sodium nitrite.", "output": {"entities": {"gene": [{"text": "glucose-6-phosphatase dehydrogenase", "start": 57, "end": 92}]}}, "schema": []}
{"input": "A vector containing a transcriptionally inactive neomycin phosphotransferase II gene was used to select promoter sequences from a pool of random genomic DNA fragments.", "output": {"entities": {"gene": [{"text": "neomycin phosphotransferase II gene", "start": 49, "end": 84}]}}, "schema": []}
{"input": "Previous analysis of the 98-bp sequence has delineated several protein-binding domains that are recognized by nuclear factors present in human brain cells.", "output": {"entities": {}}, "schema": []}
{"input": "Naturally acquired antibodies were demonstrated in some rabbits kept on commercial farms.", "output": {"entities": {}}, "schema": []}
{"input": "Biol.", "output": {"entities": {}}, "schema": []}
{"input": "Nucleotide sequences between the env gene and the LTR of SFV-1 were determined.", "output": {"entities": {"gene": [{"text": "env gene", "start": 33, "end": 41}, {"text": "LTR of SFV-1", "start": 50, "end": 62}]}}, "schema": []}
{"input": "The human cDNA was used to demonstrate that tumor necrosis factor-alpha could rapidly stimulate MARCKS gene transcription in the human promyelocytic leukemia cell line HL60.", "output": {"entities": {"gene": [{"text": "tumor necrosis factor-alpha", "start": 44, "end": 71}, {"text": "MARCKS gene", "start": 96, "end": 107}]}}, "schema": []}
{"input": "Dd PK1 RNA decreases after 6 h of starvation to re-accumulate once the cells have aggregated.", "output": {"entities": {"gene": [{"text": "Dd PK1 RNA", "start": 0, "end": 10}]}}, "schema": []}
{"input": "Young CD-1 mice, 4 days old, exposed to 0. 1% nicotine sulfate on gestational days 6-20 were compared with untreated pups of the same age to determine its effect on the development of mandibular first molars.", "output": {"entities": {}}, "schema": []}
{"input": "USF synthesized in an in vitro transcription and translation system also binds to the ADH promoter as well as to the MLP.", "output": {"entities": {"gene": [{"text": "USF", "start": 0, "end": 3}, {"text": "ADH promoter", "start": 86, "end": 98}]}}, "schema": []}
{"input": "Arterial radioactivity content after the intravenous administration of HMPAO in seven human subjects was analyzed.", "output": {"entities": {}}, "schema": []}
{"input": "Linear regression analysis was performed and the following result was obtained: clearance (HMPAO) = 0. 07 + 0. 43. rCBF with a high significance (p less than 0. 001).", "output": {"entities": {}}, "schema": []}
{"input": "Saccharomyces cerevisiae has been used widely both as a model system for unraveling the biochemical, genetic, and molecular details of gene expression and the secretion process, and as a host for the production of heterologous proteins of biotechnological interest.", "output": {"entities": {}}, "schema": []}
{"input": "Formalin activated both SNO NS and NnS neurones, but, when they responded, NS neurones (n = 5) showed only the first phase of activity while NnS neurones showed either one (n = 13) or two phases (n = 6).", "output": {"entities": {}}, "schema": []}
{"input": "Uptake of ofloxacin by Escherichia coli", "output": {"entities": {}}, "schema": []}
{"input": "A deletion series of the 5' flanking region was created from position-1329 to-74 relative to the transcriptional initiation site and similarly examined in transgenic tobacco.", "output": {"entities": {}}, "schema": []}
{"input": "Toxicity was very mild with both regimens, although sedation was significantly higher in arm B (p less than 0. 001).", "output": {"entities": {}}, "schema": []}
{"input": "Limits of energy turnover in relation to physical performance were addressed in terms of upper and lower limit, changes during a training programme and how to regulate energy balance at a changing energy turnover.", "output": {"entities": {}}, "schema": []}
{"input": "Moreover, promoters containing a TATA box in the absence of Sp1 sites or Sp1 sites in the absence of a TATA box were equally inducible in vitro, as was an RNA polymerase III promoter.", "output": {"entities": {"gene": [{"text": "Sp1 sites", "start": 60, "end": 69}, {"text": "Sp1 sites", "start": 73, "end": 82}, {"text": "RNA polymerase III promoter", "start": 155, "end": 182}]}}, "schema": []}
{"input": "Ivermectin uptake and distribution in the plasma and tissue of Sudanese and Mexican patients infected with Onchocerca volvulus.", "output": {"entities": {}}, "schema": []}
{"input": "The currently proposed extended arch repair should be reserved for the small group of infants with transverse aortic arch to ascending aorta diameter ratios (arch indices) of less than 0. 25.", "output": {"entities": {}}, "schema": []}
{"input": "DNA hybridization analysis revealed that both pigmented and nonpigmented cells of Y. pestis possess a DNA locus homologous to the Escherichia coli fur gene.", "output": {"entities": {"gene": [{"text": "Escherichia coli fur gene", "start": 130, "end": 155}]}}, "schema": []}
{"input": "We report two patients receiving maintenance valproate, one with resolving acute hepatitis C and the other with chronic persistent hepatitis C, with incidental microvesicular steatosis demonstrated on oil-red O stains.", "output": {"entities": {}}, "schema": []}
{"input": "UDP-Gal: Gal beta 1----4GlcNAc alpha 1----3-galactosyltransferase is a terminal glycosyltransferase that is widely expressed in a variety of mammalian species, with the notable exception of man, apes, and Old World monkeys.", "output": {"entities": {"gene": [{"text": "UDP-Gal: Gal beta 1----4GlcNAc alpha 1----3-galactosyltransferase", "start": 0, "end": 65}, {"text": "terminal glycosyltransferase", "start": 71, "end": 99}]}}, "schema": []}
{"input": "A synthetic oligonucleotide containing the SRE sequence from the mouse c-fos gene promoter (-299 to-322) was radioactively labeled, used as a probe for the mobility shift assay and Southwestern (DNA-protein) blotting, and also used for sequence-specific affinity chromatography.", "output": {"entities": {"gene": [{"text": "mouse c-fos gene promoter", "start": 65, "end": 90}]}}, "schema": []}
{"input": "This study indicates that this dose-intense regimen can be safely administered, even with the use of purged marrow, with an acceptable toxicity profile.", "output": {"entities": {}}, "schema": []}
{"input": "INTERVENTIONS: Patients received rt-PA, heparin, and aspirin.", "output": {"entities": {"gene": [{"text": "rt-PA", "start": 33, "end": 38}]}}, "schema": []}
{"input": "Sequence analysis of the sMtCK genomic upstream sequences reveals a typical TATAA box within the 80 base pairs (bp) that, by transfection experiments, are sufficient to promote expression of chimeric plasmids with the chloramphenicol acetyltransferase reporter.", "output": {"entities": {"gene": [{"text": "sMtCK genomic upstream sequences", "start": 25, "end": 57}, {"text": "chloramphenicol acetyltransferase reporter", "start": 218, "end": 260}]}}, "schema": []}
{"input": "Sequence analysis of the sMtCK genomic upstream sequences reveals a typical TATAA box within the 80 base pairs (bp) that, by transfection experiments, are sufficient to promote expression of chimeric plasmids with the chloramphenicol acetyltransferase reporter.", "output": {"entities": {"gene": [{"text": "sMtCK genomic upstream sequences", "start": 25, "end": 57}, {"text": "chloramphenicol acetyltransferase reporter", "start": 218, "end": 260}]}}, "schema": []}
{"input": "The cDNA segment is flanked by the immunoglobulin gene recombination signal sequences so that the cDNA segment can invert and the human IL-2R L chain is subsequently expressed under the control of the SV40 promoter.", "output": {"entities": {"gene": [{"text": "immunoglobulin gene recombination signal sequences", "start": 35, "end": 85}, {"text": "human IL-2R L chain", "start": 130, "end": 149}, {"text": "SV40 promoter", "start": 201, "end": 214}]}}, "schema": []}
{"input": "Habituation of completely isolated neurons of the edible snail to electrical stimulation.", "output": {"entities": {}}, "schema": []}
{"input": "Insulin-like growth factor 1 (IGF-1) in burn patients.", "output": {"entities": {"gene": [{"text": "Insulin-like growth factor 1", "start": 0, "end": 28}, {"text": "IGF-1", "start": 30, "end": 35}]}}, "schema": []}
{"input": "The suppression was also demonstrated in a transient expression assay in vivo using isolated barley endosperms.", "output": {"entities": {}}, "schema": []}
{"input": "RNA gel retardation and competition analyses indicate that TRP-185 binding is strongly dependent on the TAR RNA loop sequences.", "output": {"entities": {"gene": [{"text": "TRP-185", "start": 59, "end": 66}]}}, "schema": []}
{"input": "This generalization of MFP involves defining an appropriate high-resolution cost function, parametrizing the search space of the environment and source, constructing solutions of the wave equation, and utilizing a nonlinear optimization method to search the parameter landscape for the global minimum of the cost function.", "output": {"entities": {}}, "schema": []}
{"input": "The original technique was developed in the 1960' s to analyze the inner ear fluid as a diagnostic procedure (i. e., diagnostic labyrinthotomy) in acoustic neuroma suspects.", "output": {"entities": {}}, "schema": []}
{"input": "Evolution of lesions did not necessarily follow a regular progression through the later stages of the vitelliform classification.", "output": {"entities": {}}, "schema": []}
{"input": "Urine specimens containing either phencyclidine (PCP) or 11-nor-delta 9-tetrahydrocannabinol-9-carboxylic acid (9-THC-COOH) were adulterated with sodium chloride, bleach, vinegar, potassium hydroxide, liquid soap, 2-propanol, and ammonia.", "output": {"entities": {}}, "schema": []}
{"input": "Along with previously mapped genes including Ly-1 and CD20, OSBP defines a new conserved syntenic group on the long arm of chromosome 11 in the human and the proximal end of chromosome 19 in the mouse.", "output": {"entities": {"gene": [{"text": "Ly-1", "start": 45, "end": 49}, {"text": "CD20", "start": 54, "end": 58}, {"text": "OSBP", "start": 60, "end": 64}]}}, "schema": []}
{"input": "Here we show that these synthetic binding sites have a more restricted and specific ability to enhance transcription when assayed in transformed embryos.", "output": {"entities": {}}, "schema": []}
{"input": "After base-line CBF was established, hexamethonium bromide (2 mg/kg iv), ipratropium bromide (0. 5 microgram/kg iv), indomethacin (2 mg/kg iv), or intravenous 0. 9% saline was administered.", "output": {"entities": {}}, "schema": []}
{"input": "This study suggests that BSPMs are useful in the assessment of AMI in terms of diagnosis, location and extent of myocardial infarct.", "output": {"entities": {}}, "schema": []}
{"input": "Examination of immediate-early transcription factor expression during the MDI regimen revealed that RA mediated an elevated, prolonged expression of c-Jun mRNA accompanied by diminished expression of c-Fos and Jun-B mRNAs.", "output": {"entities": {"gene": [{"text": "immediate-early transcription factor", "start": 15, "end": 51}, {"text": "c-Jun mRNA", "start": 149, "end": 159}, {"text": "c-Fos", "start": 200, "end": 205}, {"text": "Jun-B mRNAs", "start": 210, "end": 221}]}}, "schema": []}
{"input": "Although heart rate and diastolic pressure rose in some degree 1 min after intubation, free and total CA concentrations did not increase during study period.", "output": {"entities": {}}, "schema": []}
{"input": "Processing, secretion, and immunoreactivity of carboxy terminally truncated dengue-2 virus envelope proteins expressed in insect cells by recombinant baculoviruses.", "output": {"entities": {"gene": [{"text": "carboxy terminally truncated dengue-2 virus envelope proteins", "start": 47, "end": 108}]}}, "schema": []}
{"input": "Seven clones encoding interferon response element binding factors have been isolated from a mouse fibroblast lambda gt11 cDNA library by using a 32P end-labeled tandem trimer of the mouse (2'-5') oligoadenylate synthetase gene interferon response element as a probe.", "output": {"entities": {"gene": [{"text": "interferon response element binding factors", "start": 22, "end": 65}, {"text": "mouse (2'-5') oligoadenylate synthetase gene", "start": 182, "end": 226}]}}, "schema": []}
{"input": "DNA-protein UV cross-linking studies indicated that UHF-1 has an electrophoretic mobility on sodium dodecyl sulfate-acrylamide gels of approximately 85 kDa and suggested that additional proteins, specific to each promoter, bind to each site.", "output": {"entities": {"gene": [{"text": "UHF-1", "start": 52, "end": 57}]}}, "schema": []}
{"input": "The specific interaction between a defined structural element of the human immunodeficiency virus mRNA (RRE, the Rev response element) and the virus-encoded protein Rev has been implicated in the regulation of the export of unspliced or singly spliced mRNA from the nucleus to the cytoplasm.", "output": {"entities": {"gene": [{"text": "RRE", "start": 104, "end": 107}, {"text": "Rev response element", "start": 113, "end": 133}, {"text": "virus-encoded protein Rev", "start": 143, "end": 168}]}}, "schema": []}
{"input": "Radiation-induced changes in the area of alveoli and septa as well as collagen content were seen 11 weeks after irradiation.", "output": {"entities": {"gene": [{"text": "collagen", "start": 70, "end": 78}]}}, "schema": []}
{"input": "The first follow-up was at a nearly constant interval of 5. 1 years in Caerphilly and 3. 2 years in Speedwell; 251 major IHD events had occurred.", "output": {"entities": {}}, "schema": []}
{"input": "Once the proliferation of fibroblasts and collagen synthesis had led to an increase of mechanical strength, no negative effect on wound healing could be detected applying the same chemotherapeutic agents.", "output": {"entities": {"gene": [{"text": "collagen", "start": 42, "end": 50}]}}, "schema": []}
{"input": "During the years 1980-87 a total of 287 persons received disability pensions in the municipality of Nordreisa in northern Norway.", "output": {"entities": {}}, "schema": []}
{"input": "HeLa and Jurkat cell lines carrying the nef gene linked to the CMV promoter or the HIV-1 LTR were isolated by coselection for neomycin resistance.", "output": {"entities": {"gene": [{"text": "nef gene", "start": 40, "end": 48}, {"text": "HIV-1 LTR", "start": 83, "end": 92}]}}, "schema": []}
{"input": "Two patients had immediate adverse effects from NMF; one had a grand mal seizure and the other developed severe abdominal pain.", "output": {"entities": {}}, "schema": []}
{"input": "The muscles from the ischemic group had significantly lower (P less than. 05) values for capillary density and capillary to fiber ratio and significantly higher intercapillary distance than those from the normal group.", "output": {"entities": {}}, "schema": []}
{"input": "Serum TNF concentrations were elevated at diagnosis and gradually decreased toward the reference limits by week 16.", "output": {"entities": {"gene": [{"text": "Serum TNF", "start": 0, "end": 9}]}}, "schema": []}
{"input": "Conclusion: inlet type VSD and perimembranous type TOF have anatomic features in which the proximal His bundle tends to be jeopardized by suturing for VSD closure.", "output": {"entities": {}}, "schema": []}
{"input": "The remainder (18. 4%) was with IgA nephropathy, which was histologically mild.", "output": {"entities": {"gene": [{"text": "IgA", "start": 32, "end": 35}]}}, "schema": []}
{"input": "Grossly, the experimental vulvitis was identical to the field condition, and bacteria indistinguishable from the inoculated strains were reisolated.", "output": {"entities": {}}, "schema": []}
{"input": "3.", "output": {"entities": {}}, "schema": []}
{"input": "Hemorrhagic shock and bacterial translocation in a swine model.", "output": {"entities": {}}, "schema": []}
{"input": "A method for establishing stimulus control of ethanol responding was developed.", "output": {"entities": {}}, "schema": []}
{"input": "In all cases, high-level expression of the truncated avian integrins was obtained.", "output": {"entities": {"gene": [{"text": "truncated avian integrins", "start": 43, "end": 68}]}}, "schema": []}
{"input": "In adulthood these rats were hyperactive and learned the active avoidance response later than the controls.", "output": {"entities": {}}, "schema": []}
{"input": "The N-terminal 115 amino acids correspond to a putative DNA-binding domain and show significant sequence similarity with other cloned IFN response factors (IRF-1 and IRF-2).", "output": {"entities": {"gene": [{"text": "IFN response factors", "start": 134, "end": 154}, {"text": "IRF-1", "start": 156, "end": 161}, {"text": "IRF-2", "start": 166, "end": 171}]}}, "schema": []}
{"input": "The patients were divided into 3 subgroups: 1) 13 N + patients with multiple hot spots (greater than 2) (N + IM); 2) 24 N + patients with single hot spots (less than or equal to 2) (N + IS); 3) 12 N-patients with single hot spots (less than or equal to 2) (N-IS).", "output": {"entities": {}}, "schema": []}
{"input": "Further, they are consistent with the suggestion that sites homologous to the CAR1 URS may be situated in the 5'-flanking regions of multiple unrelated yeast genes.", "output": {"entities": {"gene": [{"text": "CAR1 URS", "start": 78, "end": 86}]}}, "schema": []}
{"input": "Uses of orthoclone OKT3 for prophylaxis of rejection and induction in initial nonfunction in kidney transplantation.", "output": {"entities": {"gene": [{"text": "OKT3", "start": 19, "end": 23}]}}, "schema": []}
{"input": "Uses of orthoclone OKT3 for prophylaxis of rejection and induction in initial nonfunction in kidney transplantation.", "output": {"entities": {}}, "schema": []}
{"input": "In Denmark only 1-3 cases of transfusion-associated hepatitis NANB (TAH-NANB) are registered annually or about 1 case per 100, 000 units transfused.", "output": {"entities": {}}, "schema": []}
{"input": "Hence, the replacement of Phe-62 with Ser specifically affects a determinant on the lambda I light chain that is necessary for the intracellular transport of this molecule.", "output": {"entities": {"gene": [{"text": "lambda I light chain", "start": 84, "end": 104}]}}, "schema": []}
{"input": "The deduced amino acid sequence has the greatest homology (61%) to the green alga Scenedemus obliquus plastocyanin.", "output": {"entities": {"gene": [{"text": "green alga Scenedemus obliquus plastocyanin", "start": 71, "end": 114}]}}, "schema": []}
{"input": "Higher fasting serum gastrin concentration (102. 0 +/-21. 1 vs 63. 3 +/-8. 3 ng. l-1), and greater postprandial gastrin release (AUC0-120: 16690 +/-2648 vs 10654 +/-1283 ng. l-1 min) were observed after VTP-HM than after VTP-Cas.", "output": {"entities": {"gene": [{"text": "gastrin", "start": 21, "end": 28}, {"text": "gastrin", "start": 112, "end": 119}]}}, "schema": []}
{"input": "The experimental group consisted of 61 examinees class II/2 orthodontic anomalies.", "output": {"entities": {}}, "schema": []}
{"input": "Subjects were 16 male chronic schizophrenics consisting of 8 DST suppressors and 8 nonsuppressors.", "output": {"entities": {}}, "schema": []}
{"input": "In this article we propose to find out the percentage of normal occlusion and the distribution of maloclusions, according to the anteroposterior relationship between the dental archs (following the ANGLE3 classification).", "output": {"entities": {}}, "schema": []}
{"input": "We have previously identified, by screening a lambda gt11 expression library, murine protein mXBP, which binds to a sequence which overlaps the 3' end of the murine class II major histocompatibility complex A alpha gene X box, a conserved transcription element found upstream of all class II genes.", "output": {"entities": {"gene": [{"text": "murine protein mXBP", "start": 78, "end": 97}, {"text": "murine class II major histocompatibility complex A alpha gene X box", "start": 158, "end": 225}]}}, "schema": []}
{"input": "A contiguous and sequentially occupied secondary Fur-binding site in entC was protected at higher Fur concentrations, extending the protected region to + 49, and sequestering the putative Shine-Dalgarno sequence.", "output": {"entities": {"gene": [{"text": "Fur-binding site", "start": 49, "end": 65}, {"text": "entC", "start": 69, "end": 73}, {"text": "Fur", "start": 98, "end": 101}]}}, "schema": []}
{"input": "The major promoter responds strongly to virus-encoded trans activators EIA and EIV and contains four elements: a TAGA motif analogous to the TATA box, two EIIF sites present in an inverted orientation, and an ATF/CREB site.", "output": {"entities": {"gene": [{"text": "EIA", "start": 71, "end": 74}, {"text": "EIV", "start": 79, "end": 82}, {"text": "EIIF sites", "start": 155, "end": 165}, {"text": "ATF", "start": 209, "end": 212}, {"text": "CREB", "start": 213, "end": 217}]}}, "schema": []}
{"input": "Luteinizing hormone-releasing hormone analog therapy of uterine fibroid: analysis of results obtained with buserelin administered intranasally and goserelin administered subcutaneously as a monthly depot.", "output": {"entities": {"gene": [{"text": "Luteinizing hormone-releasing hormone", "start": 0, "end": 37}]}}, "schema": []}
{"input": "Although there are no octamer elements in the adenovirus genome that are known to be important for transcription, there are octamer elements in the viral terminal repeat sequences.", "output": {"entities": {}}, "schema": []}
{"input": "A 4. 8-kilobase BamHI-HindIII fragment encoding the entire Neurospora crassa CuZn superoxide dismutase gene (herein designated sod-1) was isolated from a genomic library using two 60-base deoxyoligonucleotide probes corresponding to the published N. crassa amino acid sequence.", "output": {"entities": {"gene": [{"text": "BamHI", "start": 16, "end": 21}, {"text": "HindIII", "start": 22, "end": 29}, {"text": "entire Neurospora crassa CuZn superoxide dismutase gene", "start": 52, "end": 107}, {"text": "sod-1", "start": 127, "end": 132}]}}, "schema": []}
{"input": "Using appropriate synthetic HSE oligonucleotides, three types of clones with potential HSE binding domains were isolated from a tomato lambda gt11 expression library by DNA-ligand screening.", "output": {"entities": {}}, "schema": []}
{"input": "This result indicates that separate complexes exist containing ankyrin and fodrin with either uvomorulin or Na +, K +-ATPase.", "output": {"entities": {"gene": [{"text": "ankyrin", "start": 63, "end": 70}, {"text": "fodrin", "start": 75, "end": 81}, {"text": "uvomorulin", "start": 94, "end": 104}, {"text": "Na +, K +-ATPase", "start": 108, "end": 124}]}}, "schema": []}
{"input": "These genes are expressed within a few hours of the initiation of development; their mRNAs accumulate to a peak at 12 hr and persist until culmination.", "output": {"entities": {}}, "schema": []}
{"input": "In transient cotransfection assays using Chang liver cells (CCL 13), pM1 DNA exerts a 6-to 10-fold trans-activating effect on the expression of the pSV2CAT reporter plasmid.", "output": {"entities": {}}, "schema": []}
{"input": "We have determined the nucleotide (nt) sequence of the 7. 5-kb COR segment that encompasses a cluster of six genes (CYC1, UTR1, UTR3, OSM1, tRNA (Gly) and RAD7) located on chromosome X of the yeast Saccharomyces cerevisiae.", "output": {"entities": {"gene": [{"text": "7. 5-kb COR segment", "start": 55, "end": 74}, {"text": "CYC1", "start": 116, "end": 120}, {"text": "UTR1", "start": 122, "end": 126}, {"text": "UTR3", "start": 128, "end": 132}, {"text": "OSM1", "start": 134, "end": 138}, {"text": "tRNA (Gly)", "start": 140, "end": 150}, {"text": "RAD7", "start": 155, "end": 159}]}}, "schema": []}
{"input": "No recombination signal sequences have been found contiguous to the recombination point.", "output": {"entities": {}}, "schema": []}
{"input": "The antinociceptive properties, as measured by the tail-flick and hot-plate tests, and the motor effects of an intrathecally-administered benzodiazepine agonist midazolam, alone, and in combination with morphine, was examined in rats.", "output": {"entities": {}}, "schema": []}
{"input": "To identify these sites, the deduced amino acid sequence of the 3T3-L1 adipocyte insulin receptor of the mouse was determined.", "output": {"entities": {"gene": [{"text": "adipocyte insulin receptor", "start": 71, "end": 97}]}}, "schema": []}
{"input": "PAO blocks turnover of the phosphoryl group of pp15, causing its accumulation, and thereby appears to interrupt signal transmission from the receptor to the glucose-transport system.", "output": {"entities": {"gene": [{"text": "pp15", "start": 47, "end": 51}]}}, "schema": []}
{"input": "It is likely that the sequence similarities reflect a common molecular architecture of the two heme binding sites and of a copper binding site in these enzymes.", "output": {"entities": {}}, "schema": []}
{"input": "The TraD protein (83, 899 Da) contains three hydrophobic regions, of which two are located near the amino-terminal region.", "output": {"entities": {"gene": [{"text": "TraD protein (83, 899 Da)", "start": 4, "end": 29}]}}, "schema": []}
{"input": "The protein product of orfD, which is probably a new tra gene (named traX), contains 65% hydrophobic amino acids, especially rich in alanine and leucine.", "output": {"entities": {"gene": [{"text": "orfD", "start": 23, "end": 27}, {"text": "tra gene", "start": 53, "end": 61}, {"text": "traX", "start": 69, "end": 73}]}}, "schema": []}
{"input": "A gene in Drosophila melanogaster that maps cytologically to 2C1-3 on the distal portion of the X-chromosome encodes a member of the steroid/thyroid hormone receptor superfamily.", "output": {"entities": {"gene": [{"text": "steroid/thyroid hormone receptor superfamily", "start": 133, "end": 177}]}}, "schema": []}
{"input": "A portion of Region II also resembles part of the human c-jun oncoprotein' s leucine zipper, which in turn, has been demonstrated to be the heterodimerization site between the jun and fos oncoproteins.", "output": {"entities": {"gene": [{"text": "c-jun", "start": 56, "end": 61}, {"text": "jun", "start": 176, "end": 179}, {"text": "fos oncoproteins", "start": 184, "end": 200}]}}, "schema": []}
{"input": "To determine whether vanadate could inhibit PEPCK gene transcription, a series of chimeric genes containing several deletions in the P-enolypyruvate carboxykinase promoter between-550 and-68 was linked to the structural genes for either amino-3-glycosyl phosphotransferase (neo) or chloramphenicol acetyltransferase and introduced into hepatoma cells using three methods: (a) infection with a Moloney murine leukemia virus-based retrovirus, (b) transfection and stable selection for neo expression, or (c) transient expression of chloroamphenicol acetyltransferase.", "output": {"entities": {"gene": [{"text": "PEPCK gene", "start": 44, "end": 54}, {"text": "P-enolypyruvate carboxykinase promoter", "start": 133, "end": 171}, {"text": "amino-3-glycosyl phosphotransferase", "start": 237, "end": 272}, {"text": "neo", "start": 274, "end": 277}, {"text": "chloramphenicol acetyltransferase", "start": 282, "end": 315}, {"text": "neo", "start": 483, "end": 486}, {"text": "chloroamphenicol acetyltransferase", "start": 530, "end": 564}]}}, "schema": []}
{"input": "Significant correlations were obtained between changes in SSEP in response to AS and the presence of not deep residual-organic disturbances, so-called \" ground \" in psychogenic disorders.", "output": {"entities": {}}, "schema": []}
{"input": "Both strains grew very poorly, or not at all, on nonfermentable carbon sources and exhibited, at most, only 5% of wild-type ubiquinol-cytochrome c oxidoreductase activity.", "output": {"entities": {"gene": [{"text": "wild-type ubiquinol-cytochrome c oxidoreductase", "start": 114, "end": 161}]}}, "schema": []}
{"input": "Regulation of irgA by iron in V. cholerae occurs at the transcriptional level, and there is an interrupted dyad symmetric sequence in the vicinity of the promoter that is homologous to Fur binding sites of E. coli.", "output": {"entities": {"gene": [{"text": "irgA", "start": 14, "end": 18}, {"text": "Fur binding sites", "start": 185, "end": 202}]}}, "schema": []}
{"input": "The recombinant contains the normal beta A-globin gene, the mutant gene and Ylp vector sequences between the two copies.", "output": {"entities": {"gene": [{"text": "beta A-globin gene", "start": 36, "end": 54}]}}, "schema": []}
{"input": "The characterized Y' repeated sequence families provide an experimental system in which repeated sequence interactions and subsequent evolution can be studied.", "output": {"entities": {"gene": [{"text": "Y' repeated sequence families", "start": 18, "end": 47}]}}, "schema": []}
{"input": "However, primary transcripts of a variant tRNA (Val) (UAC) gene are processing deficient under standard growth conditions (30 degrees C), due to a slightly altered 5' flanking region.", "output": {"entities": {"gene": [{"text": "variant tRNA (Val) (UAC) gene", "start": 34, "end": 63}]}}, "schema": []}
{"input": "Three of the short ORFs in the central region of BIV have been identified by location and structural similarity to the nonstructural/regulatory genes (vif, tat, and rev) of other lentiviruses; we also discovered two unique ORFs, termed W and Y, which may serve as exons for novel genes.", "output": {"entities": {"gene": [{"text": "vif", "start": 151, "end": 154}, {"text": "tat", "start": 156, "end": 159}, {"text": "rev", "start": 165, "end": 168}]}}, "schema": []}
{"input": "The contribution that alternative splicing events in c-myb expression may make on c-myb function remains to be elucidated.", "output": {"entities": {"gene": [{"text": "c-myb", "start": 53, "end": 58}, {"text": "c-myb", "start": 82, "end": 87}]}}, "schema": []}
{"input": "IgG and IgM antibody activity was determined by adding a 1: 100 dilution of serum to plates coated with A60 antigen.", "output": {"entities": {"gene": [{"text": "IgG", "start": 0, "end": 3}, {"text": "IgM", "start": 8, "end": 11}, {"text": "A60 antigen", "start": 104, "end": 115}]}}, "schema": []}
{"input": "1, among which nine have been cloned and two (potentially functional) sequenced.", "output": {"entities": {}}, "schema": []}
{"input": "The urinary protein, serum albumin, BUN and SCr all had very significant improvement.", "output": {"entities": {"gene": [{"text": "albumin", "start": 27, "end": 34}]}}, "schema": []}
{"input": "Patients with detectable serum TNF levels had significantly lower serum T3 concentrations compared to those with undetectable levels [1. 072 +/-0. 588 vs.", "output": {"entities": {"gene": [{"text": "TNF", "start": 31, "end": 34}]}}, "schema": []}
{"input": "Rats with one olfactory bulb removed and the contralateral naris closed can detect odors.", "output": {"entities": {}}, "schema": []}
{"input": "Expression of the human T cell receptor (TCR) alpha gene is regulated by a T cell-specific transcriptional enhancer that is located 4. 5 kilobases (kb) 3' to the C alpha gene segment.", "output": {"entities": {"gene": [{"text": "T cell receptor (TCR) alpha gene", "start": 24, "end": 56}, {"text": "C alpha gene segment", "start": 162, "end": 182}]}}, "schema": []}
{"input": "The Ets-1 binding site was localized to a 17-base pair (bp) region from the 3' end of T alpha 2.", "output": {"entities": {"gene": [{"text": "Ets-1 binding site", "start": 4, "end": 22}, {"text": "T alpha 2", "start": 86, "end": 95}]}}, "schema": []}
{"input": "Human T-cell leukemia virus type I (HTLV-I) encodes a 40-kDa nuclear protein, Tax, which stimulates transcription from three 21-base pair (bp) repeats in its U3 region.", "output": {"entities": {"gene": [{"text": "Tax", "start": 78, "end": 81}]}}, "schema": []}
{"input": "We have now identified, after 21 serial undiluted passages of MHV, a small DI RNA, DIssF, which is efficiently packaged into virions.", "output": {"entities": {"gene": [{"text": "small DI RNA", "start": 69, "end": 81}, {"text": "DIssF", "start": 83, "end": 88}]}}, "schema": []}
{"input": "This, together with the data obtained with haloperidol, suggests that a minimal increase in the firing rate of LC cells (+ 140%) is required before it could influence the turnover of NA, as measured by DOPAC changes.", "output": {"entities": {}}, "schema": []}
{"input": "The Mauriceville and Varkud mitochondrial plasmids are closely related, closed-circular DNAs (3. 6 and 3. 7 kb, respectively) that have characteristics of mtDNA introns and retroid elements.", "output": {"entities": {}}, "schema": []}
{"input": "The circadian rhythm, however, was not affected and the difference between minimum (12. 00 h) and maximum (18. 50 h) serum concentrations was 31. 3%.", "output": {"entities": {}}, "schema": []}
{"input": "Most strains (95%) of S. lugdunensis produced a delta hemolysin like that seen with nine other species of CNS.", "output": {"entities": {"gene": [{"text": "delta hemolysin", "start": 48, "end": 63}]}}, "schema": []}
{"input": "Experiments showed that temporary arrest of pulmonary circulation under conditions of extracorporeal circulation is attended by the development of ischemia of the respiratory pulmonary tissue.", "output": {"entities": {}}, "schema": []}
{"input": "Taste reactivity tests were used to examine the orofacial responses of alcohol preferring (P) rats and alcohol nonpreferring (NP) rats to the taste of alcohol.", "output": {"entities": {}}, "schema": []}
{"input": "1 (\" long method \") and the HML method.", "output": {"entities": {}}, "schema": []}
{"input": "No causal relations may be inferred from the correlation between the level of trapezius activity and complaints, though it indicates that individual, inexpedient muscle activity patterns may constitute an important risk factor for development of musculo-skeletal complaints.", "output": {"entities": {}}, "schema": []}
{"input": "Analysis with additional anti-peptide antibodies specific for alpha, beta, or gamma PKC indicated that all three types of PKC are expressed in JK cells; however, JKPE cells lost a major approximately 82 kDa immunoreactive cytosolic protein detectable with anti-PKC alpha antibody.", "output": {"entities": {"gene": [{"text": "alpha, beta, or gamma PKC", "start": 62, "end": 87}, {"text": "PKC", "start": 122, "end": 125}, {"text": "anti-PKC alpha antibody", "start": 256, "end": 279}]}}, "schema": []}
{"input": "Erythrocyte protoporphyrin concentration increased significantly (P less than 0. 05) by 14 days in dogs fed the basal diet, and remained significantly high relative to that in dogs of the other dietary groups for the remainder of the study.", "output": {"entities": {}}, "schema": []}
{"input": "The coding sequences of the Crry gene encompass over 25 kb of DNA, whereas the Crry-ps sequences are included within a single 5. 6-kb Eco-R1 fragment.", "output": {"entities": {"gene": [{"text": "Crry gene", "start": 28, "end": 37}, {"text": "Crry", "start": 79, "end": 83}, {"text": "ps", "start": 84, "end": 86}, {"text": "5. 6-kb Eco-R1 fragment", "start": 126, "end": 149}]}}, "schema": []}
{"input": "The genomic and transcriptional complexity of the Crry and Crry-ps genes.", "output": {"entities": {"gene": [{"text": "Crry", "start": 50, "end": 54}, {"text": "Crry", "start": 59, "end": 63}, {"text": "ps", "start": 64, "end": 66}]}}, "schema": []}
{"input": "Determination of three-dimensional imaging properties of a light microscope system.", "output": {"entities": {}}, "schema": []}
{"input": "Methods used include Cobb angle and a segmental evaluation (T7-T12) of each of convex and concave rib-vertebra angles (RVAs), rib-vertebra angle differences (RVADs), vertebral rotation, tilt and displacement.", "output": {"entities": {}}, "schema": []}
{"input": "Lars has AIDS--a more dignified life with care at home.", "output": {"entities": {}}, "schema": []}
{"input": "Accumulations of Tl + 1 (202Tl label) were 6 times those for Ga or In in the brain and muscles, and. 1 times in plasma.", "output": {"entities": {}}, "schema": []}
{"input": "A poor correlation was also observed between PbB and ALAD activity of the stearate workers.", "output": {"entities": {"gene": [{"text": "ALAD", "start": 53, "end": 57}]}}, "schema": []}
{"input": "Since the UfAP and UTMP share many biosynthetic and structural features that include site of biosynthesis in the endometrium, P4-responsiveness, the presence of the mannose 6-phosphate lysosomal recognition marker, and considerable sequence similarity, the UfAP and the UTMP may have homologous function which for both still remains obscure.", "output": {"entities": {"gene": [{"text": "UfAP", "start": 10, "end": 14}, {"text": "UTMP", "start": 19, "end": 23}, {"text": "UfAP", "start": 257, "end": 261}, {"text": "UTMP", "start": 270, "end": 274}]}}, "schema": []}
{"input": "Fifteen light for dates infants and their placentae were compared to 15 well-grown infants and their placentae.", "output": {"entities": {}}, "schema": []}
{"input": "Treating renal anaemia with recombinant human erythropoietin.", "output": {"entities": {"gene": [{"text": "erythropoietin", "start": 46, "end": 60}]}}, "schema": []}
{"input": "Basing on experimental toxicity research it was established that, out of 50 atmosphere metal corrosion inhibitors, some 14 per cent were found extremely hazardous, 42 per cent--of high level hazardous, 33 percent--of moderate and 11 per cent--of low hazardous.", "output": {"entities": {}}, "schema": []}
{"input": "The effects on reflex latencies but not on paCO2 or pHa were blocked by naloxone (2 mg/kg), and were not present in morphine-tolerant animals.", "output": {"entities": {}}, "schema": []}
{"input": "Of the remaining seven, five reacted either with immediate and strong symptoms or had spontaneously reduced gluten intake, or had an acquired IgA deficiency.", "output": {"entities": {"gene": [{"text": "gluten", "start": 108, "end": 114}, {"text": "IgA", "start": 142, "end": 145}]}}, "schema": []}
{"input": "In addition serum IgE concentrations were not statistically different.", "output": {"entities": {"gene": [{"text": "serum IgE", "start": 12, "end": 21}]}}, "schema": []}
{"input": "The findings suggest that, although iodine deficiency is the most probable cause of goiter among immigrants of the 1928 cohort, where the native population is concerned (both men and women), some other goitrogenic factor (s) must be involved.", "output": {"entities": {}}, "schema": []}
{"input": "Co-administration of 5FU, angiotensin II and microspheres via the hepatic artery may reduce drug exposure in the systemic compartment and therefore may increase the therapeutic ratio of 5FU administration via the hepatic artery.", "output": {"entities": {"gene": [{"text": "angiotensin II", "start": 26, "end": 40}]}}, "schema": []}
{"input": "In contrast, 2, 397 (74%) had one or more risk factors (not low risk); of these, 5. 3% died in 6 weeks (p less than 0. 001).", "output": {"entities": {}}, "schema": []}
{"input": "Comparison of propofol and thiopentone as anaesthetic agents for electroconvulsive therapy.", "output": {"entities": {}}, "schema": []}
{"input": "Nonvascular ophthalmic and neurologic disorders that can be confused with amaurosis fugax are listed, and an algorithm for evaluation (which includes ophthalmic examination, laboratory studies, and noninvasive carotid artery studies) is given.", "output": {"entities": {}}, "schema": []}
{"input": "These characteristics of N22/P22 indicate that it is a localized synaptically dependent event conforming to a transverse dipole with dorsal negativity and a simultaneous anterior positivity.", "output": {"entities": {}}, "schema": []}
{"input": "We evaluated the likelihood of tissues to be positive for carcinoembryonic antigen and the intensity of carcinoembryonic antigen staining in specimens of villous adenomas, mixed polypoid villous adenomas, polypoid adenomas, and diverticulitis using the peroxidase-antiperoxidase technique.", "output": {"entities": {"gene": [{"text": "carcinoembryonic antigen", "start": 58, "end": 82}, {"text": "carcinoembryonic antigen", "start": 104, "end": 128}, {"text": "peroxidase", "start": 253, "end": 263}, {"text": "antiperoxidase", "start": 264, "end": 278}]}}, "schema": []}
{"input": "These results support the view that clonidine and 6-OHDA, but not alpha-MD, have central pressor actions in the rat that oppose their antihypertensive action.", "output": {"entities": {}}, "schema": []}
{"input": "We conclude that Hansel' s stain substantially improves the recognition of eosinophiluria as compared with Wright' s stain.", "output": {"entities": {}}, "schema": []}
{"input": "The study included 139 eyes with presumed ocular histoplasmosis syndrome (POHS) and age-related macular degeneration (AMD).", "output": {"entities": {}}, "schema": []}
{"input": "Rarely, patients with locally advanced, uncontrollable, non-metastatic prostatic cancer enjoy prolonged survival.", "output": {"entities": {}}, "schema": []}
{"input": "ATP gamma S inhibition can be overcome by high concentrations of ATP, dATP, araATP, or ddATP.", "output": {"entities": {}}, "schema": []}
{"input": "Enhancer and promoter elements directing activation and glucocorticoid repression of the alpha 1-fetoprotein gene in hepatocytes.", "output": {"entities": {"gene": [{"text": "alpha 1-fetoprotein gene", "start": 89, "end": 113}]}}, "schema": []}
{"input": "The gene is contained within a 1. 8-kilobase AccI-EcoRI restriction fragment mapping at map coordinates 0. 136 to 0. 148 in the UL region of the EHV-1 genome and is transcribed from right to left.", "output": {"entities": {"gene": [{"text": "AccI", "start": 45, "end": 49}, {"text": "EcoRI", "start": 50, "end": 55}]}}, "schema": []}
{"input": "Spontaneous sensitization to cross-reacting chemicals in a proportion of control animals is strongly suggested, somewhat akin to spontaneous sensitization in patients with anaphylactoid reactions to neuromuscular blockers on first exposure, and in whom IgE antibodies are detected.", "output": {"entities": {"gene": [{"text": "IgE antibodies", "start": 253, "end": 267}]}}, "schema": []}
{"input": "The 84. 1C mAb recognizes a site on IgE which is identical or very close to the Fc epsilon R binding site, and 95. 3 recognizes a site on IgE which is related, but not identical to the Fc epsilon R binding site.", "output": {"entities": {"gene": [{"text": "84. 1C mAb", "start": 4, "end": 14}, {"text": "IgE", "start": 36, "end": 39}, {"text": "Fc epsilon R binding site", "start": 80, "end": 105}, {"text": "IgE", "start": 138, "end": 141}, {"text": "Fc epsilon R binding site", "start": 185, "end": 210}]}}, "schema": []}
{"input": "Endocrine cells were studied by means of Grimelius' silver staining and immunostaining for chromogranin, a general marker of endocrine cells.", "output": {"entities": {"gene": [{"text": "chromogranin", "start": 91, "end": 103}]}}, "schema": []}
{"input": "A potential TATA box is located 29 base pairs upstream of the first transcription initiation site.", "output": {"entities": {}}, "schema": []}
{"input": "In 76% of 59 lead-toxic children, bone lead values measured by LXRF were equal to or greater than those measured in normal and industrially exposed adults.", "output": {"entities": {}}, "schema": []}
{"input": "When considered with the known neurotoxic effects on children of \" low levels \" of exposure to lead, these results also suggest that either an excessively narrow margin of safety or insufficient safety is provided by present U. S. guidelines, which classify an elevated blood lead concentration as 25 micrograms/dl or greater.", "output": {"entities": {}}, "schema": []}
{"input": "In resting 3T3 cells, jun-D is expressed at a higher level compared to c-jun and jun-B, and its transcription is stimulated only slightly by serum growth factors.", "output": {"entities": {"gene": [{"text": "jun-D", "start": 22, "end": 27}, {"text": "c-jun", "start": 71, "end": 76}, {"text": "jun-B", "start": 81, "end": 86}]}}, "schema": []}
{"input": "Functional rearranged antibody genes were detected with JH and VH heavy chain probes and with Jk and Vk light chain probes.", "output": {"entities": {"gene": [{"text": "JH", "start": 56, "end": 58}, {"text": "VH heavy chain", "start": 63, "end": 77}, {"text": "Jk", "start": 94, "end": 96}, {"text": "Vk light chain", "start": 101, "end": 115}]}}, "schema": []}
{"input": "Isolation of Weeksella virosa (formerly CDC group IIf) from a vaginal sample.", "output": {"entities": {}}, "schema": []}
{"input": "Growth of tracheal anastomoses in growing animals", "output": {"entities": {}}, "schema": []}
{"input": "The ORF1 product was required for competence, while ORF2, which was cotranscribed with ORF1 and encoded a predicted protein of 126 amino acids, was not.", "output": {"entities": {}}, "schema": []}
{"input": "In all sessions under IFN, the latency of the P100 component of the VEP was shortened as compared to baseline conditions.", "output": {"entities": {"gene": [{"text": "IFN", "start": 22, "end": 25}]}}, "schema": []}
{"input": "This paper presents the reasons why countries to which Chagas disease is endemic should carry out the relevant research themselves.", "output": {"entities": {}}, "schema": []}
{"input": "The PETCO2 measurement during precordial compression predicted the success of defibrillation with return of spontaneous circulation.", "output": {"entities": {}}, "schema": []}
{"input": "Gastric CO2/HCO3 was determined in absence of simultaneous inhibition of acid secretion by intra-and extragastric pCO2/pH measurements in 23 persons and calculated using the equation of Henderson-Hasselbalch. pCO2 was measured with use of a new electrode.", "output": {"entities": {}}, "schema": []}
{"input": "Inefficacy of phosphine fumigation against ticks.", "output": {"entities": {}}, "schema": []}
{"input": "According to the published sequence of the CHS1 gene, this fragment contains four repeats of a TGAAACA consensus sequence previously identified in the alpha-factor-inducible BAR1 promoter [Kronstad, J.", "output": {"entities": {"gene": [{"text": "CHS1 gene", "start": 43, "end": 52}, {"text": "alpha-factor", "start": 151, "end": 163}, {"text": "BAR1 promoter", "start": 174, "end": 187}]}}, "schema": []}
{"input": "Xenopus homolog of the mos protooncogene transforms mammalian fibroblasts and induces maturation of Xenopus oocytes.", "output": {"entities": {"gene": [{"text": "Xenopus homolog of the mos protooncogene", "start": 0, "end": 40}]}}, "schema": []}
{"input": "Southern blot analyses demonstrated a low, if not single, copy number for this gene and conservation of this domain in other vertebrates.", "output": {"entities": {}}, "schema": []}
{"input": "We conclude that (a) the likelihood of detecting carcinoma or atypical hyperplasia exclusively in the adipose tissue component of grossly benign breast biopsies is extremely low, and (b) a possible cost-effective method of sampling grossly benign breast biopsies consists of initially submitting a maximum of 10 blocks of fibrous parenchyma for each case, then examining the remaining tissue histologically only if carcinoma or atypical hyperplasia is found among these blocks.", "output": {"entities": {}}, "schema": []}
{"input": "A brief account of the 1988 seminar in Shanghai on viral hepatitis A", "output": {"entities": {}}, "schema": []}
{"input": "Erythrocytic stages of mammalian malarial parasites contain acristate mitochondria whose functions are not well understood.", "output": {"entities": {}}, "schema": []}
{"input": "Restriction maps of the cloned plasmids revealed that their chromosomal inserts consisted of overlapping fragments.", "output": {"entities": {}}, "schema": []}
{"input": "In contrast, a similar fragment lacking the 38-base-pair region had no such stabilizing effect.", "output": {"entities": {}}, "schema": []}
{"input": "This TC-II enhanson, which is identical to the kappa B motif from the kappa chain enhancer, was active in both lymphoid and non-lymphoid cells, which contrasts with the previously reported lymphoid cell specificity of the kappa B motif.", "output": {"entities": {"gene": [{"text": "TC-II enhanson", "start": 5, "end": 19}, {"text": "kappa B motif", "start": 47, "end": 60}, {"text": "kappa chain enhancer", "start": 70, "end": 90}, {"text": "kappa B motif", "start": 222, "end": 235}]}}, "schema": []}
{"input": "The DNA sequences predict proteins for SRP54sc and SRP54sp that are 47% and 52% identical to SRP54mam, respectively.", "output": {"entities": {"gene": [{"text": "SRP54sc", "start": 39, "end": 46}, {"text": "SRP54sp", "start": 51, "end": 58}, {"text": "SRP54mam", "start": 93, "end": 101}]}}, "schema": []}
{"input": "Antihistamines in asthma.", "output": {"entities": {}}, "schema": []}
{"input": "We have therefore evaluated the efficacy and safety of doxazosin, a new orally active selective alpha 1 blocker, in patients with systemic hypertension with concomitant airflow limitation.", "output": {"entities": {"gene": [{"text": "alpha 1", "start": 96, "end": 103}]}}, "schema": []}
{"input": "The discussion focuses primarily on the newer drugs like angiotensin converting enzyme inhibitors, alpha-adrenergic receptor blockers, and calcium antagonists.", "output": {"entities": {"gene": [{"text": "angiotensin converting enzyme", "start": 57, "end": 86}, {"text": "alpha-adrenergic receptor", "start": 99, "end": 124}]}}, "schema": []}
{"input": "A 736-bp sequence of the 5' flanking region adjacent to the cap site of the human AFP gene shows a 61% similarity with the corresponding region of the mouse AFP gene.", "output": {"entities": {"gene": [{"text": "human AFP gene", "start": 76, "end": 90}, {"text": "mouse AFP gene", "start": 151, "end": 165}]}}, "schema": []}
{"input": "Nodular involvement of the left lung and infiltration of the mucosa of the left lower lobe bronchus followed very gradually and a monoclonal gammopathy (IgA--Type Kappa) was demonstrated.", "output": {"entities": {"gene": [{"text": "IgA--Type Kappa", "start": 153, "end": 168}]}}, "schema": []}
{"input": "These data locate the aniridia gene (AN2) and a recurrent T-cell leukemia breakpoint (TCL2) in the marker sequence, on opposite sides of MIC1.", "output": {"entities": {"gene": [{"text": "aniridia gene", "start": 22, "end": 35}, {"text": "AN2", "start": 37, "end": 40}, {"text": "T-cell leukemia breakpoint", "start": 58, "end": 84}, {"text": "TCL2", "start": 86, "end": 90}, {"text": "MIC1", "start": 137, "end": 141}]}}, "schema": []}
{"input": "A fine-structure deletion map of human chromosome 11p: analysis of J1 series hybrids.", "output": {"entities": {}}, "schema": []}
{"input": "Most of them were situated at Sylvius fissure (13 cases).", "output": {"entities": {}}, "schema": []}
{"input": "Intracellular activity studies indicated that, at ten times MBC, only penicillin had any significant activity against intracellular staphylococci, reducing survival by 28%.", "output": {"entities": {}}, "schema": []}
{"input": "The lowest detectable concentration was 1. 0 ng/ml in the serum.", "output": {"entities": {}}, "schema": []}
{"input": "The antigen-specific IgG4 antibody seems to be an index in evaluating immunotherapy objectively.", "output": {"entities": {"gene": [{"text": "antigen-specific IgG4 antibody", "start": 4, "end": 34}]}}, "schema": []}
{"input": "The differential diagnosis of both affections is based on the clinical course, sialography and CT examination which along with modern ATB treatment significantly modify hitherto used surgical therapy.", "output": {"entities": {}}, "schema": []}
{"input": "An FP mutant, AcFP875-2, had a 1. 6-kbp insertion of S. frugiperda DNA near the 5' end of these transcripts which by S1 analysis were shown to initiate within the host cell sequence.", "output": {"entities": {"gene": [{"text": "FP mutant", "start": 3, "end": 12}, {"text": "AcFP875-2", "start": 14, "end": 23}, {"text": "S1", "start": 117, "end": 119}]}}, "schema": []}
{"input": "Postcoital contraception: a family planning study.", "output": {"entities": {}}, "schema": []}
{"input": "A 0. 5 rating was intended to characterize subjects in whom mild cognitive impairment due to senile dementia of the Alzheimer type was suspected but was insufficient in degree to warrant a diagnosis of definite dementia.", "output": {"entities": {}}, "schema": []}
{"input": "An implant may release a drug either by diffusion concurrent with dissolution of the polymeric implant material without depolymerization (Type A) or by bioerosion involving depolymerization (Type B).", "output": {"entities": {}}, "schema": []}
{"input": "Improved cosmesis, extension of the scope of the problems that can be addressed with this repair (including treatment of a distal urethrocutaneous fistula) and the ease with which the Arap procedure can be performed are the advantages that this operation has over other 1-stage distal hypospadias repairs.", "output": {"entities": {}}, "schema": []}
{"input": "The galactose transporter shows both sequence and structural homology with a superfamily of sugar transporters which includes the human HepG2-erythrocyte and fetal muscle glucose transporters, the rat brain and liver glucose transporters, the Escherichia coli xylose and arabinose permeases, and the S. cerevisiae glucose, maltose, and galactose transporters.", "output": {"entities": {"gene": [{"text": "galactose transporter", "start": 4, "end": 25}, {"text": "sugar transporters", "start": 92, "end": 110}, {"text": "human HepG2-erythrocyte and fetal muscle glucose transporters", "start": 130, "end": 191}, {"text": "rat brain and liver glucose transporters", "start": 197, "end": 237}, {"text": "Escherichia coli xylose and arabinose permeases", "start": 243, "end": 290}, {"text": "S. cerevisiae glucose, maltose, and galactose transporters", "start": 300, "end": 358}]}}, "schema": []}
{"input": "The calcium requirement for hypothermic storage of the cardiac explant.", "output": {"entities": {}}, "schema": []}
{"input": "The seventh cysteine residue of CTSE is located within the activation peptide region of the proenzyme.", "output": {"entities": {"gene": [{"text": "CTSE", "start": 32, "end": 36}]}}, "schema": []}
{"input": "With both wild-type and the mutant enzymes, ATP activates both [14C] Asp in equilibrium N-carbamyl-L-aspartate (C-Asp) and the [32P] carbamyl phosphate (C-P) in equilibrium Pi exchanges.", "output": {"entities": {}}, "schema": []}
{"input": "Mapping results suggested that the complementation group identified by these mutants is allelic to the ag alpha 1 mutation identified previously.", "output": {"entities": {"gene": [{"text": "ag alpha 1", "start": 103, "end": 113}]}}, "schema": []}
{"input": "Recently, an alternatively spliced form of c-myb-encoded mRNA has been identified in murine cells containing either normal or rearranged c-myb genes.", "output": {"entities": {"gene": [{"text": "c-myb-encoded mRNA", "start": 43, "end": 61}, {"text": "c-myb genes", "start": 137, "end": 148}]}}, "schema": []}
{"input": "Metformin plasma concentrations remained unchanged except for patients transferred from 1. 5 to 2. 0 g daily to 850 mg twice daily; in these patients plasma concentrations increased from 1. 83 +/-0. 87 to 2. 50 +/-0. 89 micrograms/l (p less than 0. 01).", "output": {"entities": {}}, "schema": []}
{"input": "A significant relationship existed during the evolution of the disease between CRS/BW and gas exchange parameters (FIO2 and a/AO2 ratio) (P less than 0. 01), but gas exchange improved earlier than lung mechanics.", "output": {"entities": {}}, "schema": []}
{"input": "Liquid chromatography with amperometric detection (LC/AD) is used to determine fluazifop acid produced from the metabolism or base hydrolysis of fluazifop-butyl in soybeans and soybean oil.", "output": {"entities": {}}, "schema": []}
{"input": "The dichloromethane is removed, mobile phase solvent is added, and aliquots are injected onto a PRP-1 liquid chromatographic column; fluazifop acid is separated from coextracted compounds and detected at an applied potential of + 1. 25 V, using an amperometric electrochemical detector in the oxidation mode.", "output": {"entities": {}}, "schema": []}
{"input": "The titer of anti HSV type 1 and anti HSV type 2 antibodies in the mothers' and cord blood was determined and compared.", "output": {"entities": {"gene": [{"text": "anti HSV type 1", "start": 13, "end": 28}, {"text": "anti HSV type 2 antibodies", "start": 33, "end": 59}]}}, "schema": []}
{"input": "Kidney weight and kidney-to-body weight ratio were significantly elevated at the highest dose level after 10 weeks and at the two higher dose levels after 15 weeks of exposure.", "output": {"entities": {}}, "schema": []}
{"input": "Swim-over: an alternative method for harvesting motile spermatozoa.", "output": {"entities": {}}, "schema": []}
{"input": "A raised amplitude of the aggregation of plates and a decrease in the threshold of their sensitivity to ADP were established in the persons with types IIa and IIb HLP and in CHD without HLP.", "output": {"entities": {}}, "schema": []}
{"input": "In Experiment 2, we again used classification, but the fixed standard 75 was not at the center of the range of target numbers (20, 21,...", "output": {"entities": {}}, "schema": []}
{"input": "Among booked patients the maternal mortality rate was 0. 32 and among unbooked patients 11. 13 per 1000 deliveries.", "output": {"entities": {}}, "schema": []}
{"input": "Evidence from the structure of a number of cDNA clones, as well as S1 nuclease and primer extension studies supports the hypothesis that the PTHrP gene contains at least two mRNA transcription start points that define two putative regulatory domains.", "output": {"entities": {"gene": [{"text": "S1 nuclease", "start": 67, "end": 78}, {"text": "PTHrP gene", "start": 141, "end": 151}]}}, "schema": []}
{"input": "The transcription initiation site was determined by S1 nuclease mapping.", "output": {"entities": {"gene": [{"text": "S1 nuclease", "start": 52, "end": 63}]}}, "schema": []}
{"input": "A larval albumin-like protein was not detectable by silver staining in serum of tadpoles before the beginning of metamorphosis at stage 48.", "output": {"entities": {"gene": [{"text": "larval albumin-like protein", "start": 2, "end": 29}]}}, "schema": []}
{"input": "Behaviorally, a pain-tolerant group (PT = 29 Ss) tolerated the entire 3-min test (means = 180 +/-0 sec), while a pain-sensitive group (PS = 13 Ss) averaged only 50. 31 +/-20. 81 sec of the cold-pressor test (t = 16. 75, P less than 0. 0001), replicating our earlier studies.", "output": {"entities": {}}, "schema": []}
{"input": "Isolated proteinuria (i. e. without hematuria and/or pyuria) is a frequent finding.", "output": {"entities": {}}, "schema": []}
{"input": "Lithium delays the circadian rhythm of wheel-running in Syrian hamsters at plasma concentrations (0. 59-0. 74 mM) that also cause toxic weight loss.", "output": {"entities": {}}, "schema": []}
{"input": "When two-dimensional polyacrylamide gel electrophoretic patterns of [35S] methionine-labeled proteins secreted from cells infected with parental and recombinant viruses were compared, a spot missing from the latter corresponded in molecular weigh and isoelectric point with that predicted from the N1L ORF.", "output": {"entities": {"gene": [{"text": "N1L ORF", "start": 298, "end": 305}]}}, "schema": []}
{"input": "Buflomedil (i. v.) induced a dose-dependent increase of cardiac output at 0. 16-0. 64 mg/kg, biphasic changes at 1. 28 and 2. 56 mg/kg and a marked decrease and subsequent slight increase at a large dose of 5. 12 mg/kg.", "output": {"entities": {}}, "schema": []}
{"input": "We use the term corticosteroid-dependent IA to refer to the serious problem of chronic IA requiring maintenance prednisone therapy.", "output": {"entities": {}}, "schema": []}
{"input": "The two IL6 mRNA species are generated by alternative polyadenylation at sites separated by a distance of 1. 2 kilobases.", "output": {"entities": {"gene": [{"text": "IL6 mRNA", "start": 8, "end": 16}]}}, "schema": []}
{"input": "In one acromegalic patient visual improvement was obtained while the abnormal GH secretion remained unaltered.", "output": {"entities": {"gene": [{"text": "GH", "start": 78, "end": 80}]}}, "schema": []}
{"input": "In contrast, the PPSF + DBP side showed large amounts of bone formation, and bone almost covered the implant.", "output": {"entities": {}}, "schema": []}
{"input": "In 44 evaluable patients the response rate was 50%, with one complete response.", "output": {"entities": {}}, "schema": []}
{"input": "Thus, multiple myogenic factors that vary qualitatively and quantitatively may be responsible for the different and complex modulatory programs of actin gene expression observed during in vivo muscle differentiation.", "output": {"entities": {"gene": [{"text": "actin gene", "start": 147, "end": 157}]}}, "schema": []}
{"input": "The effect of acetazolamide (ACZ) on HCO3-and Cl-activities in inner ear fluid was investigated by ion-selective microelectrode methods.", "output": {"entities": {}}, "schema": []}
{"input": "The predicted L mRNA was 6398 nucleotides long and contained a single open reading frame corresponding to an L protein encompassing 2109 amino acids with a MW of 241, 546.", "output": {"entities": {"gene": [{"text": "L mRNA", "start": 14, "end": 20}, {"text": "L protein encompassing 2109 amino acids", "start": 109, "end": 148}]}}, "schema": []}
{"input": "Aplastic crisis in sickle cell disorders: bone marrow necrosis and human parvovirus infection.", "output": {"entities": {}}, "schema": []}
{"input": "The bactericidal activity of six new rifamycin derivatives--rifabutin (RBU), FCE 22250 (F22), rifapentine (RPE), CGP 29861 (C29), CGP 7040 (C70) and CGP 27557 (C27) and rifampicin (RMP)--have been measured against log phase and, as a better test of sterilising activity, against stationary phase cultures of Mycobacterium tuberculosis, H37Rv.", "output": {"entities": {}}, "schema": []}
{"input": "Mo + SV M-MuLV-inoculated animals became moribund at 3 to 13 months postinoculation, whereas delta Mo + SV M-MuLV-inoculated animals became moribund at 6 to 24 months postinoculation.", "output": {"entities": {}}, "schema": []}
{"input": "RVEF and LVEF both increased by about 14% (p less than 0. 05 and p less than 0. 01).", "output": {"entities": {}}, "schema": []}
{"input": "The levels of NPY-ir in the rat vas deferens were not affected by either surgical or pharmacological treatment.", "output": {"entities": {"gene": [{"text": "NPY", "start": 14, "end": 17}]}}, "schema": []}
{"input": "The primary structure and cotranscription of the petCA genes encoding the Rieske-FeS (nuclear encoded in plants) and apocytochrome f proteins has been described previously (Kallas, T., Spiller, S., and Malkin, R.", "output": {"entities": {"gene": [{"text": "petCA genes", "start": 49, "end": 60}, {"text": "Rieske-FeS", "start": 74, "end": 84}, {"text": "nuclear encoded in plants", "start": 86, "end": 111}, {"text": "apocytochrome f proteins", "start": 117, "end": 141}]}}, "schema": []}
{"input": "The Nostoc petBD genes are not closely linked to the psbB gene (encoding the 51-kDa photosystem II polypeptide) and do not contain introns as do the closely related chloroplast genes.", "output": {"entities": {"gene": [{"text": "petBD genes", "start": 11, "end": 22}, {"text": "psbB gene", "start": 53, "end": 62}, {"text": "photosystem II polypeptide", "start": 84, "end": 110}]}}, "schema": []}
{"input": "RNA blot hybridizations identified an 1. 8-kb mRNA common to cytochrome b6 and subunit IV, and an intensely hybridizing 0. 8-kb mRNA specific to the subunit IV gene probe.", "output": {"entities": {"gene": [{"text": "cytochrome b6", "start": 61, "end": 74}]}}, "schema": []}
{"input": "All of the indigo-producing bacteria had an indoxyl phosphatase with a pI of 6. 4.", "output": {"entities": {"gene": [{"text": "indoxyl phosphatase", "start": 44, "end": 63}]}}, "schema": []}
{"input": "The number of polymerases active in vitro at the E strand promoter was similar to the number of polymerases at the L strand promoter.", "output": {"entities": {}}, "schema": []}
{"input": "A family of RNA molecules in the 2. 0-2. 2-kilobase range identified with a probe from this gene was overexpressed in the resistant cells.", "output": {"entities": {}}, "schema": []}
{"input": "Intravesical chemotherapy.", "output": {"entities": {}}, "schema": []}
{"input": "Studies were performed on several superficial veins from the rabbit face to examine the relationship between beta adrenoceptor subtype distribution, intrinsic myogenic tone and sympathetic nerve innervation.", "output": {"entities": {"gene": [{"text": "beta adrenoceptor subtype", "start": 109, "end": 134}]}}, "schema": []}
{"input": "Two polyadenylation sites were used, one at the end of the early (E) region of the viral DNA, the other at the end of the late (L) region.", "output": {"entities": {"gene": [{"text": "early (E) region", "start": 59, "end": 75}, {"text": "late (L) region", "start": 122, "end": 137}]}}, "schema": []}
{"input": "We propose that the technique of low-frequency kindling is a useful experimental model in assessing the effects of antipsychotic or antiepileptic drugs on the excitability of the limbic regions.", "output": {"entities": {}}, "schema": []}
{"input": "The biosynthesis and stability of the three mutant proteins were similar to those of the wild-type erbB protein, and all three retained the ability to transform chicken embryo fibroblasts.", "output": {"entities": {"gene": [{"text": "wild-type erbB protein", "start": 89, "end": 111}]}}, "schema": []}
{"input": "Codon usage in C. reinhardtii mitochondria is highly biased, with eight codons entirely absent from all protein-coding genes; however, even though codon usage is restricted, it appears that C. reinhardtii mtDNA cannot encode the minimum number of tRNAs needed to support mitochondrial protein synthesis.", "output": {"entities": {}}, "schema": []}
{"input": "Like scrotal testes, undescended testes were hypointense to fat on sequences with a short repetition time (TR) and echo time (TE) in all cases, and hyperintense or isointense to fat on long TR/TE sequences in all but two cases.", "output": {"entities": {}}, "schema": []}
{"input": "The East African dik-dik antelope represents a miniature model ruminant for comparative studies.", "output": {"entities": {}}, "schema": []}
{"input": "Efficacy and field evaluation of Bacillus thuringiensis (H-14) and B. sphaericus against floodwater mosquitoes in California.", "output": {"entities": {}}, "schema": []}
{"input": "2 cases of type II tyrosinosis (Richner-Hanhart syndrome)", "output": {"entities": {}}, "schema": []}
{"input": "This loss was independent of drug concentration and a correction factor was employed to calculate the true free diazepam concentration.", "output": {"entities": {}}, "schema": []}
{"input": "Effects of a perfluorochemical blood substitute on diazepam binding by human albumin.", "output": {"entities": {"gene": [{"text": "human albumin", "start": 71, "end": 84}]}}, "schema": []}
{"input": "A second promoter activity was identified in the region between the two major transcriptional start sites.", "output": {"entities": {}}, "schema": []}
{"input": "Computer analysis included digital averaging, followed by digital filtering in different frequency bands in order to determine the frequency range corresponding to notches and slurs.", "output": {"entities": {}}, "schema": []}
{"input": "We also examined the relationship between the side of sinusitis and the cleft side in patients with unilateral cleft palate.", "output": {"entities": {}}, "schema": []}
{"input": "Successful use of transureteroureterostomy to salvage ureterosigmoidostomy after anastomotic failure.", "output": {"entities": {}}, "schema": []}
{"input": "We have identified and characterized the structure of the Spec1 gene in the sea urchin Strongylocentrotus purpuratus.", "output": {"entities": {"gene": [{"text": "Spec1 gene", "start": 58, "end": 68}]}}, "schema": []}
{"input": "Functional flow was evaluated using laser Doppler flowmetry (LDF), for which the output signal, blood cell flux (BCF), is expressed in terms of volts.", "output": {"entities": {}}, "schema": []}
{"input": "Our data, however, did not suggest the existence of a conversion factor for LDF signal to absolute flow values from experiment to experiment.", "output": {"entities": {}}, "schema": []}
{"input": "Quantitative analysis of the coronary stenosis was assessed before and after PTCA, and the dilatation resulted in an increase in minimal luminal cross-sectional area from 1. 1 +/-0. 8 to 2. 7 +/-1. 2 mm2.", "output": {"entities": {}}, "schema": []}
{"input": "In a previous study (Brandl, C.", "output": {"entities": {}}, "schema": []}
{"input": "The seco-steroid hormone 1, 25-dihydroxyvitamin D3 is known to induce the expression of a calcium binding protein termed calbindin-D28K in a variety of target tissues.", "output": {"entities": {"gene": [{"text": "calbindin-D28K", "start": 121, "end": 135}]}}, "schema": []}
{"input": "In addition, the calbindin-D28K promoter is composed of a variety of simple repeated sequences, some of which are components of putative regulatory signals.", "output": {"entities": {"gene": [{"text": "calbindin-D28K promoter", "start": 17, "end": 40}]}}, "schema": []}
{"input": "Organ transplantation in Denmark.", "output": {"entities": {}}, "schema": []}
{"input": "A 114-base pair sequence of predominantly repeating purine-pyrimidine nucleotides separates these two d (AC) repeats.", "output": {"entities": {}}, "schema": []}
{"input": "Evidence for a role of endogenous corticotropin-releasing factor in cold, ether, immobilization, and traumatic stress.", "output": {"entities": {"gene": [{"text": "endogenous corticotropin-releasing factor", "start": 23, "end": 64}]}}, "schema": []}
{"input": "The 210 kDa precursor is converted slowly (t 1/2 = 2 h) by proteolytic processing into a 125 kDa (alpha') and 83 kDa (beta') species.", "output": {"entities": {}}, "schema": []}
{"input": "Its predicted amino acid sequence shows extensive homology to those of Drosophila hsp70, trout hsp70, Xenopus hsp70, yeast hsp70, and some homology to the heat-inducible dnaK gene product of Escherichia coli.", "output": {"entities": {"gene": [{"text": "Drosophila hsp70", "start": 71, "end": 87}, {"text": "trout hsp70", "start": 89, "end": 100}, {"text": "Xenopus hsp70", "start": 102, "end": 115}, {"text": "yeast hsp70", "start": 117, "end": 128}, {"text": "heat-inducible dnaK gene product", "start": 155, "end": 187}]}}, "schema": []}
{"input": "At temperatures permissive for transformation, 6m2 cells contain P58gag produced from the 4. 0-kilobase (kb) viral RNA genome and P85gag-mos translated from a 3. 5-kb spliced mRNA.", "output": {"entities": {"gene": [{"text": "P58gag", "start": 65, "end": 71}, {"text": "P85gag", "start": 130, "end": 136}, {"text": "mos", "start": 137, "end": 140}]}}, "schema": []}
{"input": "Multistep transformation by defined fragments of herpes simplex virus type 2 DNA: oncogenic region and its gene product.", "output": {"entities": {}}, "schema": []}
{"input": "One group (n = 9) was premedicated with midazolam, 0. 1 mg kg-1, and atropine 0. 2-0. 4 mg i. m.", "output": {"entities": {}}, "schema": []}
{"input": "In order to study the influence of iron overload on the polymorphonuclear leucocyte (PMN) metabolism of patients on chronic hemodialysis, generation of superoxide anion (O2-) by PMN in whole blood was compared in two groups of hemodialyzed patients: group A consisted of twenty-one individuals with serum ferritin levels above 1000 ng/ml and group B of nineteen individuals with serum ferritin levels below 1000 ng/ml.", "output": {"entities": {"gene": [{"text": "ferritin", "start": 305, "end": 313}, {"text": "ferritin", "start": 385, "end": 393}]}}, "schema": []}
{"input": "Diazepam (3 mg/kg) generalized to Ro 11-6896 whereas the structurally related Ro 5-4864 (3 mg/kg and 30 mg/kg) did not.", "output": {"entities": {}}, "schema": []}
{"input": "Five patients developed metastatic spread, and all of them died of tumor.", "output": {"entities": {}}, "schema": []}
{"input": "There were no interfering peaks in the quantitation of sulbactam.", "output": {"entities": {}}, "schema": []}
{"input": "Translation of specific cellular genes from the chimeric viral-cellular transcripts seems to be unlikely.", "output": {"entities": {}}, "schema": []}
{"input": "Two mutants, each representative of a separate pet complementation group, have been analyzed.", "output": {"entities": {"gene": [{"text": "pet", "start": 47, "end": 50}]}}, "schema": []}
{"input": "A centromere in S. cerevisiae consists of a region of DNA, approximately 150 bp in length, containing three important sequence elements, which are folded with proteins into a specific conformation in the chromatin (the yeast kinetochore).", "output": {"entities": {}}, "schema": []}
{"input": "Two separate NF1-binding loci were also found in the equivalent IE68 gene of HCMV (Towne) DNA, but in this case the DNA sequence and competition filter binding experiments indicated a maximum of only four to five consensus binding sites encompassing the promoter-enhancer region.", "output": {"entities": {"gene": [{"text": "NF1-binding loci", "start": 13, "end": 29}, {"text": "IE68 gene", "start": 64, "end": 73}]}}, "schema": []}
{"input": "The previously described four sets of 13-to 18-base-pair interspersed repeat elements between-55 and-580 provide most of the high basal transcriptional strength, whereas the arrangement of further upstream tandemly repeated NF1-binding sites may contribute significantly to the expanded biological host range for expression of SCMV IE94 compared with HCMV IE68.", "output": {"entities": {"gene": [{"text": "NF1-binding sites", "start": 224, "end": 241}, {"text": "SCMV IE94", "start": 327, "end": 336}, {"text": "HCMV IE68", "start": 351, "end": 360}]}}, "schema": []}
{"input": "Active lambda and kappa antibody gene rearrangement in Abelson murine leukemia virus-transformed pre-B cell lines.", "output": {"entities": {"gene": [{"text": "lambda and kappa antibody gene", "start": 7, "end": 37}]}}, "schema": []}
{"input": "Influence of cyclo-oxygenase inhibition and of leukotriene receptor blockade on pulmonary vascular pressure/cardiac index relationships in hyperoxic and in hypoxic dogs.", "output": {"entities": {"gene": [{"text": "cyclo-oxygenase", "start": 13, "end": 28}, {"text": "leukotriene receptor", "start": 47, "end": 67}]}}, "schema": []}
{"input": "Northern analyses of RNAs from mouse tissues and cell lines indicated that p11 mRNA levels vary widely.", "output": {"entities": {"gene": [{"text": "p11 mRNA", "start": 75, "end": 83}]}}, "schema": []}
{"input": "Morphine produced a dose-dependent bradycardia followed by tachycardia.", "output": {"entities": {}}, "schema": []}
{"input": "The PSS gene was subcloned into a 1. 1-kb fragment of the yeast DNA on the YEp13 vector.", "output": {"entities": {"gene": [{"text": "PSS gene", "start": 4, "end": 12}]}}, "schema": []}
{"input": "The gene is essential for yeast vegetative growth.", "output": {"entities": {}}, "schema": []}
{"input": "Bacteriologic culture of pancreatic tissue was positive in 6/8 IB and 3/17 NIB rats (p less than 0. 01).", "output": {"entities": {}}, "schema": []}
{"input": "These similarities suggest that these E2 proteins are structurally and evolutionarily related.", "output": {"entities": {"gene": [{"text": "E2 proteins", "start": 38, "end": 49}]}}, "schema": []}
{"input": "Histological examination revealed a small simple renal cyst associated with renal cell carcinoma.", "output": {"entities": {}}, "schema": []}
{"input": "Thus, prostacyclin enhanced the autoregulative property of the inner ear vessels.", "output": {"entities": {}}, "schema": []}
{"input": "The method is accurate, with good precision and adequate sensitivity.", "output": {"entities": {}}, "schema": []}
{"input": "Factors influencing the bond strength between glass polyalkenoate (ionomer) cements and dentine.", "output": {"entities": {}}, "schema": []}
{"input": "Van der Ende, R.", "output": {"entities": {}}, "schema": []}
{"input": "Clinical findings were: height 183 cm, weight 62 kg, increased length of lower limbs, P2-A2 pilosity and micropenis.", "output": {"entities": {}}, "schema": []}
{"input": "The 8 patients receiving Ir192 implant in addition to external radiation showed improved (p = 0. 06) survival compared to the 9 receiving external only: median 15 months (range 1. 5-34 + months) versus 7 months (range 2. 5-21 months).", "output": {"entities": {}}, "schema": []}
{"input": "No effect was found on grooming behavior.", "output": {"entities": {}}, "schema": []}
{"input": "Clinical and biological correlates of panic states.", "output": {"entities": {}}, "schema": []}
{"input": "Effects of long-term parenteral nutrition on gastrin release in dogs.", "output": {"entities": {"gene": [{"text": "gastrin", "start": 45, "end": 52}]}}, "schema": []}
{"input": "The mean weight and height velocities were 148% and 122% of the standard, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "In 64% a small cardiac vein does not exist, but its origin, the right marginal vein, joins the system of anterior cardiac veins.", "output": {"entities": {}}, "schema": []}
{"input": "The results of these experiments indicate that at least two upstream activator sequences (UAS) mediate maximum induction by galactose.", "output": {"entities": {}}, "schema": []}
{"input": "Reversal of the increase in apomorphine-induced stereotypy and aggression in REM sleep deprived rats by dopamine agonist pretreatments.", "output": {"entities": {}}, "schema": []}
{"input": "The genetic basis for the expression of a latent VH allotype in the rabbit was investigated.", "output": {"entities": {"gene": [{"text": "VH allotype", "start": 49, "end": 60}]}}, "schema": []}
{"input": "Potentiation of the thrombolytic efficacy of single-chain urokinase (Pro-urokinase) by heparin.", "output": {"entities": {"gene": [{"text": "single-chain urokinase", "start": 45, "end": 67}, {"text": "Pro-urokinase", "start": 69, "end": 82}]}}, "schema": []}
{"input": "The variability is most likely a result of alternative splicing of exons from the primary elastin transcripts.", "output": {"entities": {"gene": [{"text": "elastin transcripts", "start": 90, "end": 109}]}}, "schema": []}
{"input": "This led to the conclusion that the metatarsal artery should be used for toe MP joint grafts, while the unilateral proper digital artery is suitable for toe PIP joint grafts, together with concomitant or dorsal cutaneous vein.", "output": {"entities": {}}, "schema": []}
{"input": "Factors involved in specific transcription by mammalian RNA polymerase II: purification, genetic specificity, and TATA box-promoter interactions of TFIID.", "output": {"entities": {"gene": [{"text": "RNA polymerase II", "start": 56, "end": 73}, {"text": "TFIID", "start": 148, "end": 153}]}}, "schema": []}
{"input": "You make the diagnosis.", "output": {"entities": {}}, "schema": []}
{"input": "Conservative treatment of bladder carcinoma by partial cystectomy and interstitial iridium 192.", "output": {"entities": {}}, "schema": []}
{"input": "The results presented suggest that TIQ reduces the turnover rate of the nigrostriatal dopamine neurons after repeated administration for a long period in mice.", "output": {"entities": {}}, "schema": []}
{"input": "During a 28-week promotion bioassay, groups of 30 male CD-1 mice were treated once with 50 microliter of either DMBA (1. 0 mg/ml) or acetone, rested for 2 weeks, and then treated twice per week with test material for the remaining 25 weeks.", "output": {"entities": {}}, "schema": []}
{"input": "An 11-month-old girl suffering from Dandy-Walker malformation (DWM) associated with tetralogy of Fallot (TOF) is presented.", "output": {"entities": {}}, "schema": []}
{"input": "The median survival is not reached with a median follow-up time of 9. 6 years.", "output": {"entities": {}}, "schema": []}
{"input": "Critical evaluation of various methods of determining markers of fetal maturity in amniotic fluid", "output": {"entities": {}}, "schema": []}
{"input": "Neuromyelitis optica (Devic' s syndrome): not always multiple sclerosis.", "output": {"entities": {}}, "schema": []}
{"input": "Effect of the methods of cutaneous administration of methyl isobutyl ketone on its toxicity", "output": {"entities": {}}, "schema": []}
{"input": "The temporal and static plasma concentration-effect relationships were evaluated by pharmacodynamic modeling and linear regression.", "output": {"entities": {}}, "schema": []}
{"input": "Fourteen patients were in the multifocal disease group; 13 were detected by SPECT and 10 by TCT.", "output": {"entities": {}}, "schema": []}
{"input": "The SSB-poly (dT) affinity is too high to measure in buffers containing even 5 M NaCl; however, in 1. 8-2. 5 M NaBr, we measure alpha log Kobsd/alpha log [NaBr] =-5. 7 +/-0. 7, with a lower value of omega T/O = 130 +/-70.", "output": {"entities": {"gene": [{"text": "SSB", "start": 4, "end": 7}]}}, "schema": []}
{"input": "Minor differences were noted with latamoxef producing mild persistant elevation of prothrombin time (0. 7 second) associated with depression of factor II and factor VII.", "output": {"entities": {"gene": [{"text": "prothrombin", "start": 83, "end": 94}, {"text": "factor II", "start": 144, "end": 153}, {"text": "factor VII", "start": 158, "end": 168}]}}, "schema": []}
{"input": "Plasma renin activity does not predict the antihypertensive efficacy of chlorthalidone.", "output": {"entities": {"gene": [{"text": "Plasma renin", "start": 0, "end": 12}]}}, "schema": []}
{"input": "Cephradine 250 mg at night for 12 months was given as a prophylactic measure to 33 female patients of mean age 41. 6 years, who had a history in the preceding 12 months of between three and 24 (median = 7) episodes of frequency and/or dysuria.", "output": {"entities": {}}, "schema": []}
{"input": "The activity of the EGF receptor promoter can be modulated by E1A protein and receptor RNA levels increased by stimulation with phorbol ester or fetal calf serum.", "output": {"entities": {"gene": [{"text": "EGF receptor promoter", "start": 20, "end": 41}, {"text": "E1A protein", "start": 62, "end": 73}]}}, "schema": []}
{"input": "By Felix Lagrange, 1918.", "output": {"entities": {}}, "schema": []}
{"input": "The epidermal growth factor (EGF) receptor, which exhibits intrinsic protein tyrosine kinase activity, undergoes a rapid, intramolecular self-phosphorylation reaction following EGF activation.", "output": {"entities": {"gene": [{"text": "epidermal growth factor (EGF) receptor", "start": 4, "end": 42}, {"text": "protein tyrosine kinase", "start": 69, "end": 92}, {"text": "EGF", "start": 177, "end": 180}]}}, "schema": []}
{"input": "A case of AIDS-related complex (ARC/LAS) in a health worker", "output": {"entities": {}}, "schema": []}
{"input": "Vimentin positivity was noted in the undifferentiated and fibroblastic components.", "output": {"entities": {"gene": [{"text": "Vimentin", "start": 0, "end": 8}]}}, "schema": []}
{"input": "The spermicide nonoxynol-9 is a member of a homologous series of alkylphenol-ethoxylates (polyethoxyethanols) of general formula C9H19-C6H6-O-(CH2CH2O) n-1 CH2CH2OH.", "output": {"entities": {}}, "schema": []}
{"input": "Depending on the location and size of the mass, a wide range of clinical presentations is associated with the lesion.", "output": {"entities": {}}, "schema": []}
{"input": "The development and distribution of Trypanosoma congolense, T vivax and T brucei in the skin of goats was examined after the animals were bitten by infected Glossina morsitans centralis.", "output": {"entities": {}}, "schema": []}
{"input": "During the observation period of 0. 4-30 weeks, cardiac white spots on the right ventricle of BALB/c mice were first detected at three weeks (6 of 20 mice; 30%), and the maximal incidence of cardiac white spots was obtained at nine weeks (39 of 44 mice; 88%).", "output": {"entities": {}}, "schema": []}
{"input": "Increasing the RH beyond 32% resulted in solvation of the peroxy radical, sterically hindering the radical from entering the propagation transition state.", "output": {"entities": {}}, "schema": []}
{"input": "PATIENTS and METHODS: Thallium-201 myocardial scintigraphy was performed at rest and after 0. 56 mg/kg intravenous dipyridamole during four minutes in 16 patients with sarcoidosis.", "output": {"entities": {}}, "schema": []}
{"input": "Which cineangiographically assessed anatomic variable correlates best with functional measurements of stenosis severity? A comparison of quantitative analysis of the coronary cineangiogram with measured coronary flow reserve and exercise/redistribution thallium-201 scintigraphy.", "output": {"entities": {}}, "schema": []}
{"input": "Water content and equilibrium water partition in immature cartilage.", "output": {"entities": {}}, "schema": []}
{"input": "Ischemic heart disease, age of more than 75 years, and the fact that the patient was a woman were independent predictors of poor cardiac function.", "output": {"entities": {}}, "schema": []}
{"input": "Liquid chromatographic method for determination of citreoviridin in corn and rice.", "output": {"entities": {}}, "schema": []}
{"input": "The incidence of cryptosporidiosis in young children was determined by staining of faecal specimens with a modified Kinyoun stain.", "output": {"entities": {}}, "schema": []}
{"input": "The 4 degrees stimuli were found to elicit scalp distributions for the pattern reversal P100 and the pattern onset C1 consistent with striate and extrastriate visual cortical origins respectively.", "output": {"entities": {}}, "schema": []}
{"input": "A Golgi study of the sixth layer of the cerebral cortex.", "output": {"entities": {}}, "schema": []}
{"input": "Man and insect, past, present, future", "output": {"entities": {}}, "schema": []}
{"input": "Mean fluorosis scores, however, were similar.", "output": {"entities": {}}, "schema": []}
{"input": "Autonomic dysfunctions were restricted to tonic pupils.", "output": {"entities": {}}, "schema": []}
{"input": "On the other hand, if the measured angle ANB is smaller than the calculated angle, the skeletal relation is Class III.", "output": {"entities": {}}, "schema": []}
{"input": "These data should be useful in developing reagents for heterozygote detection and prenatal diagnosis of 11 beta-hydroxylase deficiency, the second most frequent cause of congenital adrenal hyperplasia.", "output": {"entities": {"gene": [{"text": "11 beta-hydroxylase", "start": 104, "end": 123}]}}, "schema": []}
{"input": "Neither ethanol nor estrogen has been shown to cause UROD-deficiency in animals.", "output": {"entities": {"gene": [{"text": "UROD", "start": 53, "end": 57}]}}, "schema": []}
{"input": "Although not common, the disorder is the most frequently diagnosed disturbance of porphyrin metabolism in many countries, and further insight into its unusual pathogenesis may clarify the hepatotoxic effects of the 4 etiologic agents.", "output": {"entities": {}}, "schema": []}
{"input": "This means that the loss of recessives must be calculated by using a hypergeometric and not a binomial model as Fisher did.", "output": {"entities": {}}, "schema": []}
{"input": "The poly (A) segment of the RNA was selectively cross-linked to the 72, 000-molecular-weight protein (72K protein).", "output": {"entities": {}}, "schema": []}
{"input": "Possible pathogenetic mechanisms of hemopoietic changes in response to space flight effects are described.", "output": {"entities": {}}, "schema": []}
{"input": "Development of a yeast system to assay mutational specificity.", "output": {"entities": {}}, "schema": []}
{"input": "As a last resort, it may be possible to maintain a patient on dialysis in reasonable health with a DiaTAP button graft complex infected with Staphylococcus epidermidis and intermittent positive blood cultures using long term vancomycin therapy.", "output": {"entities": {}}, "schema": []}
{"input": "Reward value of prosodic features of language for autistic, mentally retarded, and normal children.", "output": {"entities": {}}, "schema": []}
{"input": "Due to its relatively soluble chemical form, 90Sr was rapidly translocated from lung to bone where a substantial portion was retained for a long period of time.", "output": {"entities": {}}, "schema": []}
{"input": "Artificial ventilation was conducted using a tidal volume of 10 ml X kg-1 and a rate of 10 to 12 c X min-1.", "output": {"entities": {}}, "schema": []}
{"input": "Significantly lower heart rate reactivity and significantly less pronounced left temporal artery pulse amplitude responses were found in non-medicated TH subjects than in controls.", "output": {"entities": {}}, "schema": []}
{"input": "An epidemiological survey of rheumatic valve disease and rheumatic fever in primary and secondary school students in Jiangxi Province", "output": {"entities": {}}, "schema": []}
{"input": "Heat-labile-like enterotoxin (LT) was produced by 26 of 42 stool isolates (62%), while only 1 of the 42 isolates (2%) produced enterotoxinlike activity in suckling mice; 65% of the cytotoxin-producing strains also produced an LT-like material.", "output": {"entities": {"gene": [{"text": "LT", "start": 30, "end": 32}, {"text": "LT-like", "start": 226, "end": 233}]}}, "schema": []}
{"input": "The nucleotide sequences of the human and murine ornithine decarboxylase mRNAs share an 85% homology, even in their 3'-noncoding regions.", "output": {"entities": {"gene": [{"text": "human and murine ornithine decarboxylase mRNAs", "start": 32, "end": 78}]}}, "schema": []}
{"input": "The absolute concentrations of alpha 2-plasmin inhibitor, alpha 2-macroglobulin, and antithrombin III increased with exercise (all P less than 0. 005), but when concentrations were corrected for acute shifts of plasma water during exercise, the quantity of these inhibitors actually decreased (all P less than 0. 005).", "output": {"entities": {"gene": [{"text": "alpha 2-plasmin", "start": 31, "end": 46}, {"text": "alpha 2-macroglobulin", "start": 58, "end": 79}, {"text": "antithrombin III", "start": 85, "end": 101}]}}, "schema": []}
{"input": "In the normal, basal (unstimulated) condition there were no significant correlations (p greater than 0. 05) between the systolic blood pressure and dopamine (r = 0. 09), norepinephrine (r = 0. 26), or epinephrine (r = 0. 27), nor were there significant correlations between melatonin and dopamine (r =-0. 01), norepinephrine (r =-0. 26), or growth hormone (r = 0. 17).", "output": {"entities": {"gene": [{"text": "growth hormone", "start": 341, "end": 355}]}}, "schema": []}
{"input": "In cases of 1 degrees HPT, the plasma 1, 25-(OH) 2D level rose significantly in all cases (P less than 0. 05), although the pattern of the increase was not uniform.", "output": {"entities": {}}, "schema": []}
{"input": "It is largely predicted by lupus anticoagulant (estimated by activated partial thromboplastin time) and/or antibody to cardiolipin.", "output": {"entities": {"gene": [{"text": "thromboplastin", "start": 79, "end": 93}]}}, "schema": []}
{"input": "Data from 119 men and 40 women undergoing coronary angiography provide an opportunity to compare these associations in relation to a direct and continuous measure of atherosclerosis while controlling for age, sex, income, hypertension, serum cholesterol, smoking, angina, diabetes, family history of heart disease, Type A behavior pattern, and hostility.", "output": {"entities": {}}, "schema": []}
{"input": "The presence in such patients of antibodies to adrenaline and noradrenaline is indicative of considerable disruption of catecholamine biotransformation.", "output": {"entities": {}}, "schema": []}
{"input": "Effects of a low-energy laser beam on the cells of the newt embryo", "output": {"entities": {}}, "schema": []}
{"input": "Samples from 1415 neurological patients were used to study the diagnostic value of acid alpha 1-glycoprotein in the lumbar cerebrospinal fluid.", "output": {"entities": {"gene": [{"text": "acid alpha 1-glycoprotein", "start": 83, "end": 108}]}}, "schema": []}
{"input": "Comparison of the amino acid sequence of the M RNA product of Uukuniemi virus with that of Punta Toro and Rift Valley fever viruses showed in both cases a weak homology that was more pronounced for the proteins located at the COOH-terminal end of the precursor.", "output": {"entities": {"gene": [{"text": "M RNA product of Uukuniemi virus", "start": 45, "end": 77}]}}, "schema": []}
{"input": "The purpose of this study is twofold: (1) to present a parallel form of the Gudjonsson Suggestibility Scale (GSS, Form 1); (2) to study test-retest reliabilities of interrogative suggestibility.", "output": {"entities": {}}, "schema": []}
{"input": "The average deviations in the X-ray counts of the constant elements from the series means were used to correct the recorded count of the variable element in each block.", "output": {"entities": {}}, "schema": []}
{"input": "To evaluate the relative accuracy of continuous wave (CW) and high pulse repetition frequency (HPRF) Doppler for estimating aortic transvalvular pressure gradients, Doppler examinations with both devices were obtained in 87 consecutive patients with aortic valve disease.", "output": {"entities": {}}, "schema": []}
{"input": "The number of fecal pellets ingested peaked at 5 to 6 weeks old (13 pellets/day) and gradually decreased, thereafter (2. 1 pellets at 78 weeks old, 1. 5 pellets at 104 weeks old).", "output": {"entities": {}}, "schema": []}
{"input": "Two of these six cases showed mucosal spread without stromal invasion (type A); the remaining four cases presented a direct extension (type B) from muscle-invasive carcinomas of the bladder.", "output": {"entities": {}}, "schema": []}
{"input": "The development of a data base is described which can be used as common reference for ECG computer programs analyzing 12 or 15 simultaneously recorded leads.", "output": {"entities": {}}, "schema": []}
{"input": "Contraction of the tracheal muscle and the activity of stretch receptors in the trachea", "output": {"entities": {}}, "schema": []}
{"input": "The selenium level and glutathione peroxidase activity in the blood, liver, and stomach mucosa were significantly higher in the high-selenium diet group than in the low-selenium diet group.", "output": {"entities": {"gene": [{"text": "glutathione peroxidase", "start": 23, "end": 45}]}}, "schema": []}
{"input": "Amikacin was the most stable and tobramycin was the least stable aminoglycoside under the conditions tested.", "output": {"entities": {}}, "schema": []}
{"input": "This may explain in part a secular trend towards reduced birthweight for gestation in preterm infants.", "output": {"entities": {}}, "schema": []}
{"input": "Nickel is the most common cause of allergic contact dermatitis in Singapore, resulting in positive reactions in patch tests between 7 and 14%.", "output": {"entities": {}}, "schema": []}
{"input": "Findings of positive potentials showed that N1 originated in the area of ventral gray matter through the ventro-lateral column and N2 through the dorsal column.", "output": {"entities": {}}, "schema": []}
{"input": "Splenectomized patients are predisposed toward developing overwhelming bacterial infections.", "output": {"entities": {}}, "schema": []}
{"input": "The rats were used for the study of the effects of sepsis on the utilization of exogenous fat emulsion.", "output": {"entities": {}}, "schema": []}
{"input": "The possibility of a hereditary disorder leading to a minor defect in elastic fibre structure which could be responsible for the spontaneous lesions is discussed.", "output": {"entities": {}}, "schema": []}
{"input": "N-Substituted trimethylsilylcarbamates were tested as derivatizing reagents for gas chromatographic analysis.", "output": {"entities": {}}, "schema": []}
{"input": "The growing drug problem is also reflected in the increasing number of cases of hepatitis B and of drug-related deaths.", "output": {"entities": {}}, "schema": []}
{"input": "Under the same hematocrit and flow conditions, the rate of oxygen saturation decrease was significantly higher for the sickle cells than for normal cells.", "output": {"entities": {}}, "schema": []}
{"input": "The risk for these complications is increased by the following factors: multiple gestation, the combination of magnesium sulfate and beta-adrenergic agonist, and the use of adrenocortico-steroids to hasten fetal pulmonary maturity.", "output": {"entities": {}}, "schema": []}
{"input": "Intensification of human myocardial contractile activity as affected by blood serum", "output": {"entities": {}}, "schema": []}
{"input": "Inhibition of histalog-stimulated gastric secretion by 40 749 RP, a new long-acting gastric antisecretory agent.", "output": {"entities": {}}, "schema": []}
{"input": "Five-year prospective study of peripheral white blood cells in infectious mononucleosis.", "output": {"entities": {}}, "schema": []}
{"input": "Novel multigene families encoding highly repetitive peptide sequences.", "output": {"entities": {}}, "schema": []}
{"input": "The M-3 subtype was an adverse prognostic factor.", "output": {"entities": {}}, "schema": []}
{"input": "In addition, marked hypertension accompanied this disorder and all abnormalities, including the hypertension, responded to 1-desamino-8-D-arginine vasopressin therapy.", "output": {"entities": {"gene": [{"text": "1-desamino-8-D-arginine vasopressin", "start": 123, "end": 158}]}}, "schema": []}
{"input": "In 19 patients vagotomy not only curbed the bleeding but provided definitive therapy (Visick I-II); 4 patients died (mortality rate 16%).", "output": {"entities": {}}, "schema": []}
{"input": "A yeast DNA fragment carrying the gene CP A1 encoding the small subunit of the arginine pathway carbamoyl-phosphate synthetase has been sequenced.", "output": {"entities": {"gene": [{"text": "gene CP A1", "start": 34, "end": 44}, {"text": "carbamoyl-phosphate synthetase", "start": 96, "end": 126}]}}, "schema": []}
{"input": "The H2 receptor antagonists and sucralfate cost about the same and have few side effects.", "output": {"entities": {"gene": [{"text": "H2 receptor", "start": 4, "end": 15}]}}, "schema": []}
{"input": "Such studied acquired with low energy or medium energy collimation and a window centered on the 159 keV 123I photopeak contain appreciable septal breakthrough signals originating from Compton scatter of high energy photons primarily from 124I.", "output": {"entities": {}}, "schema": []}
{"input": "The concentrations of apo A-I and apo A-II of abstainers decreased significantly compared with the corresponding changes in controls.", "output": {"entities": {"gene": [{"text": "apo A-I", "start": 22, "end": 29}, {"text": "apo A-II", "start": 34, "end": 42}]}}, "schema": []}
{"input": "Thyrotropin-releasing hormone-induced contraction of urethral and vaginal muscle.", "output": {"entities": {"gene": [{"text": "Thyrotropin-releasing hormone", "start": 0, "end": 29}]}}, "schema": []}
{"input": "Results of this study indicate that GLC of short chain fatty acids produced on agar medium by anaerobes, combined with simple tests such as Gram' s stain and colonial morphology, may allow fir direct presumptive genus identification from an initial pure agar culture.", "output": {"entities": {}}, "schema": []}
{"input": "Tissue pressure, rCBF, and water content were measured from gray matter in the central core and the peripheral margin of the MCA territory over 6 h after MCAO.", "output": {"entities": {}}, "schema": []}
{"input": "Dissolution of the Pt-30% Ir microelectrode tip was observed by scanning electron microscopy at charge densities as low as 200 microC/cm2 X ph (1 A/cm2), whereas erosion of activated iridium microelectrodes occurred only at the highest charge and current densities (3200 microC/cm2 X ph, 16 A/cm2).", "output": {"entities": {}}, "schema": []}
{"input": "The results from the first five years of follow up in 1972 showed a 4. 7-fold excess mortality for ischaemic and other heart diseases (ICD A83-A84) compared with a comparable reference cohort of paper mill workers.", "output": {"entities": {}}, "schema": []}
{"input": "The primary CT findings were misinterpreted as a brain infarct or possibly a tumour.", "output": {"entities": {}}, "schema": []}
{"input": "However, kidneys perfused for 72 hr demonstrated more similar renal functions when tested by either IMPK or IBPK.", "output": {"entities": {}}, "schema": []}
{"input": "It has been reported that rat blood chloroform levels were significantly decreased after treatment with ClO2.", "output": {"entities": {}}, "schema": []}
{"input": "For this purpose, a simple respiration-control device has been developed that enables the patient to monitor breath-holding during successive scans.", "output": {"entities": {}}, "schema": []}
{"input": "In the 10 patients with a more severe degree of steatorrhea the decrease in fat loss approached 20% and a close relationship was found (r = 0. 84, p less than 0. 01) between the extent of the fatty acid loss on placebo and the decrease of this loss on taurine.", "output": {"entities": {}}, "schema": []}
{"input": "Polysorbate 80 did not have a direct stimulant or relaxant effect on either guinea pig ileum or rat uterus, however, it antagonised the contractions induced by acetylcholine, histamine, barium, 5-hydroxytryptamine and carbachol in a dose-dependent manner.", "output": {"entities": {}}, "schema": []}
{"input": "Either a UV detector set at 268 nm or an electrochemical (EC) detector set at a potential of + 0. 9 V (versus Ag/AgCl/3 M NaCl) was used to monitor the drug.", "output": {"entities": {}}, "schema": []}
{"input": "The mean transfer ratios of the drug into the genital tissues to the concentration in the uterine arterial blood were such that the transfer ratio into the portio vaginalis was the highest, followed by the uterine cervix and the myometrium, and that into the oviduct was the lowest with about 1/2 that into the portio vaginalis.", "output": {"entities": {}}, "schema": []}
{"input": "Lower extremity weight bearing under various standing conditions in independently ambulatory patients with hemiparesis.", "output": {"entities": {}}, "schema": []}
{"input": "These results were compared with those obtained in-D mothers and pups, after giving the mothers an oral supplement (10 i. u. vitamin D3/day) during the period of lactation (20 days).", "output": {"entities": {}}, "schema": []}
{"input": "Treatment with oxyphenylbutazone and hydrocortisone failed to inhibit the raised serum CPN levels.", "output": {"entities": {"gene": [{"text": "serum CPN", "start": 81, "end": 90}]}}, "schema": []}
{"input": "40, 000).", "output": {"entities": {}}, "schema": []}
{"input": "Duration of remission in advanced gastric cancer patients responding to sequential dose of MTX and 5-FU", "output": {"entities": {}}, "schema": []}
{"input": "The fast real-time digital processing of the N2 and flow signals incorporated filtering, delay compensation, and corrections for the effects of changes in gas composition and temperature.", "output": {"entities": {}}, "schema": []}
{"input": "National Institutes of Health Consensus Development Conference Statement.", "output": {"entities": {}}, "schema": []}
{"input": "Diagnosis: progressive multifocal leukoencephalopathy.", "output": {"entities": {}}, "schema": []}
{"input": "The imino proton of T3 in the O6meG. T 12-mer and G3 in the O6meG. N 12-mer helix, which are associated with the modification site, resonate at unusually high field (8. 5 to 9. 0 ppm) compared to imino protons in Watson-Crick base pairs (12. 5 to 14. 5 ppm).", "output": {"entities": {}}, "schema": []}
{"input": "Postnatal volumetric development of the prefrontal cortex in the rat.", "output": {"entities": {}}, "schema": []}
{"input": "We also observed that the predictive ability of the selected attitudes and orientations increased considerably from 1975 to 1982.", "output": {"entities": {}}, "schema": []}
{"input": "They also discuss the existing nomenclature.", "output": {"entities": {}}, "schema": []}
{"input": "Estral cycle in white rats in the low and high mountains of Kirghizia", "output": {"entities": {}}, "schema": []}
{"input": "Studies on the organic matrix of human ear ossicles", "output": {"entities": {}}, "schema": []}
{"input": "Sensitization to hyperlactatemia induced by phenformin after subtotal ablation of the pancreas.", "output": {"entities": {}}, "schema": []}
{"input": "Effect of variations in time interval between treatment with BCG and quartz dust on translocation of quartz dust from the lungs to their regional lymph nodes.", "output": {"entities": {}}, "schema": []}
{"input": "Metastasis of colon carcinoma to the lip.", "output": {"entities": {}}, "schema": []}
{"input": "Pre-beta-1 lipoprotein and early detection of risk factors for coronary heart disease.", "output": {"entities": {"gene": [{"text": "Pre-beta-1 lipoprotein", "start": 0, "end": 22}]}}, "schema": []}
{"input": "I.", "output": {"entities": {}}, "schema": []}
{"input": "A study in vivo of adrenergic receptors in the rectum and in the internal and sphincter of the cat.", "output": {"entities": {"gene": [{"text": "adrenergic receptors", "start": 19, "end": 39}]}}, "schema": []}
{"input": "Problems common to pediatrics and anesthesiology", "output": {"entities": {}}, "schema": []}
{"input": "Clinical course and nursing care of patients with decubitus ulcer--use of pillows stuffed with buckwheat chaff", "output": {"entities": {}}, "schema": []}
{"input": "Re-examining methylbenzene (toluene) as a treatment for Ancylostomum caninum.", "output": {"entities": {}}, "schema": []}
{"input": "Teratological studies on SF-837.", "output": {"entities": {}}, "schema": []}
{"input": "60th birthday of colonel prof. e. cerny m. d.", "output": {"entities": {}}, "schema": []}
{"input": "Morphology of bacteriophages of Klebsiella bacilli.", "output": {"entities": {}}, "schema": []}
{"input": "Benign intramural tumors of the esophagus", "output": {"entities": {}}, "schema": []}
{"input": "Methyl mercury intoxication in rat kidneys.", "output": {"entities": {}}, "schema": []}
{"input": "Disability insurance under social security.", "output": {"entities": {}}, "schema": []}
{"input": "Polycythemia-1973.", "output": {"entities": {}}, "schema": []}
{"input": "Analysis of clearance curve of rose bengal-I-131", "output": {"entities": {}}, "schema": []}
{"input": "VII.", "output": {"entities": {}}, "schema": []}
{"input": "Effect of a high-intensity SHF field on the blood coagulation system", "output": {"entities": {}}, "schema": []}
{"input": "Plastic solution of elbow joint ankylosis with a decorticated cylindrical flap", "output": {"entities": {}}, "schema": []}
{"input": "Effects of ionizing radiation in the human oral cavity and oropharynx: results of a survey.", "output": {"entities": {}}, "schema": []}
{"input": "The Twentieth Anniversary of the Pomeranian Medical Academy.", "output": {"entities": {}}, "schema": []}
{"input": "Study of antinuclear autoantibodies by immunofluorescence technic in collagen diseases", "output": {"entities": {"gene": [{"text": "collagen", "start": 69, "end": 77}]}}, "schema": []}
{"input": "Some reflexions apropos of a personal statistical study of 513 arterial embolisms", "output": {"entities": {}}, "schema": []}
{"input": "Reactivities to horse anti-lymphocyte globulin.", "output": {"entities": {"gene": [{"text": "horse anti-lymphocyte globulin", "start": 16, "end": 46}]}}, "schema": []}
{"input": "The effect of osmotic flow on the distribution of horseradish peroxidase within the intercellular spaces of toad bladder epithelium.", "output": {"entities": {"gene": [{"text": "horseradish peroxidase", "start": 50, "end": 72}]}}, "schema": []}
{"input": "Nitrogen-hydrogen tautomerism in porphyrins and chlorins.", "output": {"entities": {}}, "schema": []}
{"input": "A possible role for the mixed function oxidase enzyme system in the requirement for selenium in the rat.", "output": {"entities": {"gene": [{"text": "oxidase", "start": 39, "end": 46}]}}, "schema": []}
{"input": "Periodic breathing and apnea in preterm infants.", "output": {"entities": {}}, "schema": []}
{"input": "Working session report: in vivo-in vitro screening.", "output": {"entities": {}}, "schema": []}
{"input": "Dynamics of hospital stay in peptic ulcer patients", "output": {"entities": {}}, "schema": []}
{"input": "A case of M hemoglobinosis", "output": {"entities": {}}, "schema": []}
{"input": "Results of the official inspection of the commercial anti-inflammatory enzyme preparations containing chymotrypsin and trypsin by means of modified NF 13 methods", "output": {"entities": {"gene": [{"text": "chymotrypsin", "start": 102, "end": 114}, {"text": "trypsin", "start": 119, "end": 126}]}}, "schema": []}
{"input": "The content of glucosamine and galactosamine in tartar", "output": {"entities": {}}, "schema": []}
{"input": "The non-role of fluoride in the control of plasma calcium in the parathyroidectomized rat.", "output": {"entities": {}}, "schema": []}
{"input": "Modification of the growth of Tetrahymena by compounds which affect the adrenergic mechanism.", "output": {"entities": {}}, "schema": []}
{"input": "Factors influencing in vitro skin permeability factor production by Vibrio cholerae.", "output": {"entities": {"gene": [{"text": "skin permeability factor", "start": 29, "end": 53}]}}, "schema": []}
{"input": "Midge control in flood channels.", "output": {"entities": {}}, "schema": []}
{"input": "Tolerance test of HB 419 in animal experiments", "output": {"entities": {}}, "schema": []}
{"input": "The distribution of body fluids following hemorrhage and resuscitation in combat casualties.", "output": {"entities": {}}, "schema": []}
{"input": "Once more Hong Kong influenza in the Netherlands", "output": {"entities": {}}, "schema": []}
{"input": "Early disagnosis of cancer--50 per cent of all patients could be cured", "output": {"entities": {}}, "schema": []}
{"input": "Difficulties bound to measuring of sputum viscosity", "output": {"entities": {}}, "schema": []}
{"input": "The absolute configuration at C-2 in monocrotalic acid.", "output": {"entities": {}}, "schema": []}
{"input": "CO2 assimilation by chloroplasts illuminated on filter paper.", "output": {"entities": {}}, "schema": []}
{"input": "The effect of low dosage radiation on metabolism and function of the rat kidney damaged by ischemia", "output": {"entities": {}}, "schema": []}
{"input": "Quantitation of exocrine IgA in human serum in health and disease.", "output": {"entities": {"gene": [{"text": "exocrine IgA", "start": 16, "end": 28}]}}, "schema": []}
{"input": "Iodine metabolism in chronic thyroiditis.", "output": {"entities": {}}, "schema": []}
{"input": "Propagation and hormone production by human normal and malignant trophoblast in rats.", "output": {"entities": {}}, "schema": []}
{"input": "Morphogenesis of the trochanter produced by femoral regeneration in the phasmid Carausius morosus Br", "output": {"entities": {}}, "schema": []}
{"input": "3.", "output": {"entities": {}}, "schema": []}
{"input": "Nephrectomy applied to cattle", "output": {"entities": {}}, "schema": []}
{"input": "Evaluation of automatic blood cell counters.", "output": {"entities": {}}, "schema": []}
{"input": "The effect of a constant magnetic field on the phagocytic activity of Paramecia", "output": {"entities": {}}, "schema": []}
{"input": "Relations between adrenergic mechanisms and analgesic effects", "output": {"entities": {}}, "schema": []}
{"input": "The bearing of season and sequence of calving on frequency of male, female and total calvings in Hariana cows.", "output": {"entities": {}}, "schema": []}
{"input": "Effect of castration on pituitary and serum LH and FSH in testosterone-sterilized rats.", "output": {"entities": {"gene": [{"text": "pituitary and serum LH", "start": 24, "end": 46}, {"text": "FSH", "start": 51, "end": 54}]}}, "schema": []}
{"input": "The significance of the phenolphthalein sulphatase test for the differentiation and identification of Nocardia species.", "output": {"entities": {"gene": [{"text": "phenolphthalein sulphatase", "start": 24, "end": 50}]}}, "schema": []}
{"input": "Effect of heparin on the inactivation of serum lipoprotein lipase by the liver in unanesthetized dogs.", "output": {"entities": {"gene": [{"text": "serum lipoprotein lipase", "start": 41, "end": 65}]}}, "schema": []}
{"input": "Experimental chlorpromazine cataracts.", "output": {"entities": {}}, "schema": []}
{"input": "The need in the small hospital.", "output": {"entities": {}}, "schema": []}
{"input": "Statistics of the past 5 years", "output": {"entities": {}}, "schema": []}
{"input": "Naphthalene and paradichlorobenzene in clinical toxicology", "output": {"entities": {}}, "schema": []}
{"input": "Story of a hospital that filmed its employee orientation program.", "output": {"entities": {}}, "schema": []}
{"input": "Value of the method of passive hemagglutination with polysaccharide C in detecting C-reactive protein as compared to precipitation in capillaries and slide latex test with anti-CRP serum", "output": {"entities": {"gene": [{"text": "C-reactive protein", "start": 83, "end": 101}, {"text": "anti-CRP", "start": 172, "end": 180}]}}, "schema": []}
{"input": "Antimicrobial substance isolated from an acorn extract.", "output": {"entities": {}}, "schema": []}
{"input": "On the amount and significance of the effective glucose level in tumors.", "output": {"entities": {}}, "schema": []}
{"input": "The immuno-purified mRNA in the polysome complex was used to prepare cDNA with which to probe a D. melanogaster genomic library.", "output": {"entities": {}}, "schema": []}
{"input": "Eight recombinant DNA clones of endogenous murine leukemia virus (MuLV)-related DNA sequences have been isolated from a lambdaphage genomic library of Balb/c mouse DNA.", "output": {"entities": {}}, "schema": []}
{"input": "Mature mRNA for cytosolic phosphoenolpyruvate carboxykinase of the chicken is 2. 8 kilobases in length, similar to that previously noted for mRNA coding for the same enzyme in the rat.", "output": {"entities": {"gene": [{"text": "cytosolic phosphoenolpyruvate carboxykinase of the chicken", "start": 16, "end": 74}]}}, "schema": []}
{"input": "Upstream activation sites of the CYC1 gene of Saccharomyces cerevisiae are active when inverted but not when placed downstream of the \" TATA box \".", "output": {"entities": {"gene": [{"text": "CYC1 gene", "start": 33, "end": 42}]}}, "schema": []}
{"input": "Plasma and erthrocyte lipid profile and lipoprotein lipase activity in postheparin plasma on vasectomized rabbits were studied and also the incidence of atherosclerosis in different arterial beds.", "output": {"entities": {"gene": [{"text": "lipoprotein lipase", "start": 40, "end": 58}]}}, "schema": []}
{"input": "Propranolol also effectively controlled her familial tremor.", "output": {"entities": {}}, "schema": []}
{"input": "The distribution phase is followed by an elimination phase with a much longer half-life (mean value 375 min) and a volume of distribution of approximately 200-400 l.", "output": {"entities": {}}, "schema": []}
{"input": "Plasma secretin, pancreozymin, and somatostatin-like hormone in chronic renal failure patients.", "output": {"entities": {"gene": [{"text": "Plasma secretin", "start": 0, "end": 15}, {"text": "pancreozymin", "start": 17, "end": 29}, {"text": "somatostatin-like hormone", "start": 35, "end": 60}]}}, "schema": []}
{"input": "We have followed 37 phenytoin-treated patients with reduced serum IgA concentrations for 2-7 years.", "output": {"entities": {"gene": [{"text": "serum IgA", "start": 60, "end": 69}]}}, "schema": []}
{"input": "Unusual course of plasmocytosis.", "output": {"entities": {}}, "schema": []}
{"input": "Toxicity was significant in selected cases; three patients developed WBC counts less than 1, 000/mm3 and one of these patients died with sepsis.", "output": {"entities": {}}, "schema": []}
{"input": "At Cabras (Oristano), a town characterized by a high incidence of thalassaemia and G6PD deficiency less than half the people between 18 and 35 have a fair knowledge of genetic diseases and of their prevention.", "output": {"entities": {"gene": [{"text": "G6PD", "start": 83, "end": 87}]}}, "schema": []}
{"input": "Experience with the tensor fasciae latae free flap.", "output": {"entities": {}}, "schema": []}
{"input": "The abluminal surface is often almost entirely encircled by a thick layer of fibrillary connective tissue.", "output": {"entities": {}}, "schema": []}
{"input": "The customary coupling reagent sulfanilic acid has been replaced by 1, 3-dimethylbarbituric acid; CNCl is produced in the flow through system directly from KCN and chloramine T.", "output": {"entities": {}}, "schema": []}
{"input": "Among six different library isolates containing 6. 5-to 7-kb IAP units, some restriction sites were highly conserved whereas others varied in both occurrence and position.", "output": {"entities": {"gene": [{"text": "6. 5-to 7-kb IAP units", "start": 48, "end": 70}]}}, "schema": []}
{"input": "During the period from May to August, 1978, an epidemic of hand, foot and mouth disease (HFMD) occurred in Gifu prefecture.", "output": {"entities": {}}, "schema": []}
{"input": "We have investigated the requirements of the CH gene switch by characterizing two rearranged gamma 2b genes from a gamma 2b producing mouse myeloma (MPC-11).", "output": {"entities": {"gene": [{"text": "CH gene", "start": 45, "end": 52}, {"text": "rearranged gamma 2b genes", "start": 82, "end": 107}, {"text": "gamma 2b", "start": 115, "end": 123}]}}, "schema": []}
{"input": "WR-2721 (S-2-(3 aminopropylamino) ethylphosphorothioic acid) has been investigated for its ability to protect gut, lung, and testis, as well as fibrosarcoma (FSa) tumor nodules, in the lungs of mice from gamma-radiation injury.", "output": {"entities": {}}, "schema": []}
{"input": "The ensembles are considered to be one of the forms of activity of the structured morphofunctional cortical units, i. e. the columns.", "output": {"entities": {}}, "schema": []}
{"input": "The strong conservation of the inverted terminal repeat sequence may reflect a common integration mechanism for VL30 elements and MuLV proviruses.", "output": {"entities": {"gene": [{"text": "VL30 elements", "start": 112, "end": 125}]}}, "schema": []}
{"input": "In conclusion, these studies indicate that LiCl (1) decreases histamine-stimulated gastric acid secretion, and (2) diminishes bile-induced disruption of the gastric mucosal barrier in the canine Heidenhain pouch.", "output": {"entities": {}}, "schema": []}
{"input": "Gel route preparation of low fusing dental porcelain frit.", "output": {"entities": {}}, "schema": []}
{"input": "The dnaQ-lacZ and the rnh-lacZ fused genes were constructed and hybrid proteins with beta-galactosidase activity were produced.", "output": {"entities": {"gene": [{"text": "dnaQ", "start": 4, "end": 8}, {"text": "lacZ", "start": 9, "end": 13}, {"text": "rnh", "start": 22, "end": 25}, {"text": "lacZ", "start": 26, "end": 30}, {"text": "beta-galactosidase", "start": 85, "end": 103}]}}, "schema": []}
{"input": "The primary structure of the GAL7 5' flanking region has many features common to those of multicellular eukaryotic genes.", "output": {"entities": {"gene": [{"text": "GAL7 5' flanking region", "start": 29, "end": 52}]}}, "schema": []}
{"input": "Sweet oranges, mandarin, grapefruit, lemon, and lime are generally used for processing.", "output": {"entities": {}}, "schema": []}
{"input": "Bepridil, a calcium antagonist with a half-life of approximately 42 hours, was compared with placebo in a double-blind, randomized, crossover trial.", "output": {"entities": {}}, "schema": []}
{"input": "Climatic treatment of children with respiratory allergy", "output": {"entities": {}}, "schema": []}
{"input": "The susceptibility of the PPNG strains to clinically relevant antibiotics varied with the plasmid pattern; this stresses the necessity of permanent surveillance of gonococcal infections and of regular evaluation of the recommendations for antimicrobial treatment.", "output": {"entities": {}}, "schema": []}
{"input": "If facilities for measurements of O2 consumption and hence metabolic rate are available, these should be utilized.", "output": {"entities": {}}, "schema": []}
{"input": "This generally means an energy intake of 1. 4 to 1. 6 times the energy expenditure, with a N intake of 250 to 400 mg/kg/day.", "output": {"entities": {}}, "schema": []}
{"input": "The statistical analysis of data of TRH test on a sample of 57 healthy volunteers has permitted an evaluation of the upper limits of the normal thyrotropin response; the secretory area (As) was shown to be more discriminating.", "output": {"entities": {"gene": [{"text": "TRH", "start": 36, "end": 39}, {"text": "thyrotropin", "start": 144, "end": 155}]}}, "schema": []}
{"input": "Transitory subclinical and permanent hypothyroidism in the course of subacute thyroiditis (de Quervain).", "output": {"entities": {}}, "schema": []}
{"input": "It is concluded that axillo-axillary by-pass is a simple solution for a complex haemodynamic, clinical and therapeutic problem.", "output": {"entities": {}}, "schema": []}
{"input": "Endothelium of the central ear artery of an anesthetized rabbit is damaged by placing artery forceps on the ear directly over the vessel.", "output": {"entities": {}}, "schema": []}
{"input": "Hydrocortisone seems to be unable to hinder the postdenervation changes in the muscle membrane whereas high doses of the hormone are able to induce changes in the muscle membrane.", "output": {"entities": {}}, "schema": []}
{"input": "Significant clinical differences between the patients treated with and without AMB were longer survival time following diagnosis of illness (P less than 0. 05) and more frequent cranial nerve signs in the treated patients (P = 0. 089).", "output": {"entities": {}}, "schema": []}
{"input": "Catch-up growth was observed only for a 12-month period in 4 children with a bone age of 7 to 8 years.", "output": {"entities": {}}, "schema": []}
{"input": "The present paper elucidates the existing discrepancies, and offers a consistent terminology incorporating also such terms as \" additivity \", \" potentiation \", and \" simple similarity \".", "output": {"entities": {}}, "schema": []}
{"input": "Brainstem auditory evoked responses (BAERs) and quantitative saccadic eye movement studies provide information on the integrity of pathways traversing the brainstem.", "output": {"entities": {}}, "schema": []}
{"input": "The salient clinical features, the problems of management and the modern approaches to the reconstruction of facial deformities seen in this disease are described.", "output": {"entities": {}}, "schema": []}
{"input": "The rational for the prophylactic treatment, the therapy of the meningopathy and AIL-AIEOP protocols are exposed.", "output": {"entities": {}}, "schema": []}
{"input": "Hepatitis B vaccine", "output": {"entities": {}}, "schema": []}
{"input": "The Sarns 51F cavoatrial cannula decompressed the venous system as efficiently as the double caval cannulas.", "output": {"entities": {}}, "schema": []}
{"input": "Three experiments contrasted the effects of 6-hydroxydopamine-induced lesions of the ventral noradrenergic and dorsal noradrenergic projections, predominantly to hypothalamus and cortex, respectively, upon body weight changes and food-related behaviour in the rat.", "output": {"entities": {}}, "schema": []}
{"input": "Female Wistar rats were fed a liquid diet, Sustacal, which contained ethanol (40% of calories) or isocaloric sucrose.", "output": {"entities": {}}, "schema": []}
{"input": "Introductory remarks.", "output": {"entities": {}}, "schema": []}
{"input": "Combination of a Shwachman syndrome and a complex granulocyte function disorder in a girl", "output": {"entities": {}}, "schema": []}
{"input": "Trial 3 broiler chickens were maintained on control feed until they reached 3 weeks of age at which time they were taken off of feed for 2. 5 hr and then placed on either control feed or feed containing 4. 0 ppm ochratoxin A, and heart rate and blood pressure were measured every half hour through 7 hr.", "output": {"entities": {}}, "schema": []}
{"input": "While these findings may reflect the sensitivity of a thick myocardial wall to ischaemia during surgery, the postoperative recovery was not related to the serum CK-MB level.", "output": {"entities": {"gene": [{"text": "serum CK-MB", "start": 155, "end": 166}]}}, "schema": []}
{"input": "Using a MOS-Hypersil reversed-phase column with a phosphate buffer--acetonitrile mobile phase, baseline separation of antipyrine, its metabolites 3-hydroxymethylantipyrine, norantipyrine and 4-hydroxyantipyrine, and the internal standard, phenacetin, was achieved within 6 min.", "output": {"entities": {}}, "schema": []}
{"input": "Serum lipids and lipoproteins of 29 insulin dependent diabetic children have been determined and related to the metabolic status of the patients.", "output": {"entities": {"gene": [{"text": "insulin", "start": 36, "end": 43}]}}, "schema": []}
{"input": "The AD components were markedly more dependent on the affective state of the rat then was the V1 component.", "output": {"entities": {}}, "schema": []}
{"input": "HBB concentration in the fetuses indicated little, if any accumulation.", "output": {"entities": {}}, "schema": []}
{"input": "All samples exhibited a decline in ethanol concentration, with most losses falling within the expected 20 to 40 mg% range.", "output": {"entities": {}}, "schema": []}
{"input": "Pilot study of blood coagulation in gout patients.", "output": {"entities": {}}, "schema": []}
{"input": "Further, the reduction in 5-hydroxytryptophan (5-HTP) accumulation by LSD showed regional differences in inhibition by methiothepin (hypothalamus greater than cortex greater than striatum) which paralleled the autoreceptor antagonist activity of methiothepin in vitro. (ABSTRACT TRUNCATED AT 250 WORDS)", "output": {"entities": {}}, "schema": []}
{"input": "Effects of methiothepin and lysergic acid diethylamide on serotonin release in vitro and serotonin synthesis in vivo: possible relation to serotonin autoreceptor function.", "output": {"entities": {"gene": [{"text": "serotonin autoreceptor", "start": 139, "end": 161}]}}, "schema": []}
{"input": "In a recent measles epidemic in El Paso, TX, 120, 000 records were screened using these criteria, and as a result 13, 000 students were vaccinated.", "output": {"entities": {}}, "schema": []}
{"input": "Twenty-one percent of these patients had neurologic disease that appeared to be responsible for the tinnitus.", "output": {"entities": {}}, "schema": []}
{"input": "Bullous angiolymphoid hyperplasia with eosinophilia", "output": {"entities": {}}, "schema": []}
{"input": "The hypertension with elevated PRA, however, was resistant to the angiotensin II (AII) analog [Sar1, Ile8] ALL.", "output": {"entities": {"gene": [{"text": "angiotensin II", "start": 66, "end": 80}, {"text": "AII", "start": 82, "end": 85}]}}, "schema": []}
{"input": "Volume of distribution of total DMDZ (range, 1. 33 to 6. 30 l/kg) and of unbound DMDZ after correction for protein binding (range, 43 to 243 l/kg) was larger in women than in men of all ages, and in the elderly as opposed to the young.", "output": {"entities": {}}, "schema": []}
{"input": "Effects of dopamine and of a dopaminergic blocker, haloperidol, on the responses of carotid body chemoreceptors to hypoxia and hypercapnia were investigated in 16 anesthetized cats.", "output": {"entities": {}}, "schema": []}
{"input": "1.", "output": {"entities": {}}, "schema": []}
{"input": "The alterations in differentiation of osteoprogenitor cells, together with the failure of mineralization, resulted in significantly lower rates of bone formation (as measured by fluorochrome labeling) in the magnesium-deficient rats.", "output": {"entities": {}}, "schema": []}
{"input": "The role of DNA rearrangement and alternative RNA processing in the expression of immunoglobulin delta genes.", "output": {"entities": {"gene": [{"text": "immunoglobulin delta genes", "start": 82, "end": 108}]}}, "schema": []}
{"input": "There is now a significative difference between age group 1-5 and the others (p Less Than 0, 02).", "output": {"entities": {}}, "schema": []}
{"input": "Factor VIII procoagulant activity, antigen concentration and von Willebrand activity as ristocetin cofactor were determined several times in 10 patients with DIC.", "output": {"entities": {"gene": [{"text": "Factor VIII", "start": 0, "end": 11}, {"text": "von Willebrand", "start": 61, "end": 75}, {"text": "ristocetin cofactor", "start": 88, "end": 107}]}}, "schema": []}
{"input": "In silicosis, significant relationships between patients and sons were not seen with respect to arterial blood gas determinations and ventilatory responses except for Paco2 of patients and hypercapnic ventilatory responses of sons.", "output": {"entities": {}}, "schema": []}
{"input": "For steers the urinary N values were 403 and 295 mg/kg W0. 75 at 200 and 350 kg live weight respectively and total N excretion including faecal N was 408 and 320 mg/kg W0. 75.", "output": {"entities": {}}, "schema": []}
{"input": "TEMTU and DPTU were the most potent teratogens.", "output": {"entities": {}}, "schema": []}
{"input": "Similar observations were made with unilateral pneumothorax of 15 cmH2O for 30 min.", "output": {"entities": {}}, "schema": []}
{"input": "Fibromuscular intimal thickening was seen in the ascending and thoracic aorta of the swine fed 62, 500 IU of vitamin D3/kg of diet for three months duration; and after 3 months of vitamin D3 withdrawal, atherosclerotic lesions were found.", "output": {"entities": {}}, "schema": []}
{"input": "Detection of exercise-induced asynergy by M-mode echocardiography.", "output": {"entities": {}}, "schema": []}
{"input": "Both groups were subjected to tests of delayed hypersensitivity with Candidin, Trycophytin and Tuberculin.", "output": {"entities": {"gene": [{"text": "Candidin", "start": 69, "end": 77}, {"text": "Trycophytin", "start": 79, "end": 90}, {"text": "Tuberculin", "start": 95, "end": 105}]}}, "schema": []}
{"input": "Efficacy of cervical spine immobilization methods.", "output": {"entities": {}}, "schema": []}
{"input": "Circulating platelets may be activated by exposed triple-helical collagen in atherosclerotic lesions in Mg-deficient ruminants.", "output": {"entities": {"gene": [{"text": "collagen", "start": 65, "end": 73}]}}, "schema": []}
{"input": "In the ultramarathon runner the testosterone levels sharply rose at the beginning of the training session (from the 7, 20 ng/ml to 11, 50 ng/ml after 20' training), and subsequently decrease after 3 hours (9, 20 ng/ml) and at the end of the 6 hours training (4, 60 ng/ml).", "output": {"entities": {}}, "schema": []}
{"input": "Terbutaline; a beta2-adrenergic agonist, and aminophyllin, a phosphodiesterase inhibitor, were given separately, or in combination, to rabbit fetuses on the 28th day of gestation.", "output": {"entities": {}}, "schema": []}
{"input": "The hyperacute phase of posterolateral myocardial infarction.", "output": {"entities": {}}, "schema": []}
{"input": "After a year of planning in the Laboratory Assistants' School in Stockholm: new education for laboratory assistants is now arranged", "output": {"entities": {}}, "schema": []}
{"input": "The electrocardiogram.", "output": {"entities": {}}, "schema": []}
{"input": "The Authors have proposed to develop this research employing a preparation containing exclusively a cortisonic, the desametazone, in order to evaluate the alterations of the dentinogenesis to be attributed to such component.", "output": {"entities": {}}, "schema": []}
{"input": "Secretory IgA and serum immunoglobulins as indices of the local immunity of the intestinal mucosa in acute leukemias", "output": {"entities": {"gene": [{"text": "Secretory IgA", "start": 0, "end": 13}, {"text": "serum immunoglobulins", "start": 18, "end": 39}]}}, "schema": []}
{"input": "Fluorometric methods can also provide information about porphyrin binding sites that is useful in understanding porphyrin transport and clearance.", "output": {"entities": {}}, "schema": []}
{"input": "The monoexponential rate of clearance of tracer--obtained from the portion of the residue-detection curve reflecting metabolism of fatty acid incorporated into neutral lipids--correlated directly with induced changes in tension-time index after injections into the left atrium (r = 0. 96, n = 12), right atrium (r = 0. 86, n = 14), and ear vein (r = 0. 93, n = 14).", "output": {"entities": {}}, "schema": []}
{"input": "Specific IgE levels decreased slightly, but always remained within the pathological range.", "output": {"entities": {"gene": [{"text": "IgE", "start": 9, "end": 12}]}}, "schema": []}
{"input": "Correlation between intraocular involvement and systemic outcome was poor.", "output": {"entities": {}}, "schema": []}
{"input": "The results indicate that folate compounds decrease formate accumulation after methanol by stimulating formate oxidation or utilization and suggest a possible use for folates in the treatment of certain cases of human methanol poisoning.", "output": {"entities": {}}, "schema": []}
{"input": "The \" cracked-tooth \" syndrome.", "output": {"entities": {}}, "schema": []}
{"input": "The foregoing results show that CXD has high efficacy and safety and it can be said that it is a drug required in the pediatric field.", "output": {"entities": {}}, "schema": []}
{"input": "Based on peptide map similarities, partial amino-terminal sequence data, and common genetic origin, it is suggested that p60 and p62 have identical amino acid sequences carboxy-terminal to the p60 initiator methionine (residue 21 of p62).", "output": {"entities": {"gene": [{"text": "p60", "start": 121, "end": 124}, {"text": "p62", "start": 129, "end": 132}, {"text": "p60", "start": 193, "end": 196}, {"text": "p62", "start": 233, "end": 236}]}}, "schema": []}
{"input": "Diagnosis of phenylalanine hydroxylase deficiency (phenylketonuria).", "output": {"entities": {"gene": [{"text": "phenylalanine hydroxylase", "start": 13, "end": 38}]}}, "schema": []}
{"input": "The uncomplicated cases of typhoid fever were found to have an intact CMIR as compared to the complicated cases.", "output": {"entities": {}}, "schema": []}
{"input": "There was a significant correlation between tubular diameter and spg (r = 0. 68, P less than 0. 001) suggesting that tubular diameter measurements in histological sections could be used to predict sperm production.", "output": {"entities": {}}, "schema": []}
{"input": "The differential investigation of lipoproteins, however, showed that the high-density lipoprotein (HDL) fractions are absolutely or relatively decreased with respect to low-density lipoproteins (LDL) in cerebral infarcts and in transient ischaemic attacks.", "output": {"entities": {"gene": [{"text": "high-density lipoprotein", "start": 73, "end": 97}, {"text": "HDL", "start": 99, "end": 102}, {"text": "low-density lipoproteins", "start": 169, "end": 193}, {"text": "LDL", "start": 195, "end": 198}]}}, "schema": []}
{"input": "A note on some consequences of UV vision in birds.", "output": {"entities": {}}, "schema": []}
{"input": "Parasitological and pathological findings in capuchin monkeys infected with Schistosoma japonicum or Schistosoma mansoni.", "output": {"entities": {}}, "schema": []}
{"input": "In the past, immunology in Singapore was mainly confined to serology for the diagnosis of certain infectious diseases.", "output": {"entities": {}}, "schema": []}
{"input": "Modification of enteral resorption by cytostatic therapy", "output": {"entities": {}}, "schema": []}
{"input": "In vitro penetration tests of human sperm into cervical mucus were introduced in order to study the interaction between sperm and cervical mucus.", "output": {"entities": {}}, "schema": []}
{"input": "Vibrio fluvialis (group F vibrio) in Maharashtra.", "output": {"entities": {}}, "schema": []}
{"input": "The hormonal response to a standardized bicycle exercise test was studied in 11 male cadets exposed to a course of 107 h of continuous activity with less than 2 h sleep.", "output": {"entities": {}}, "schema": []}
{"input": "At an ambient temperature of 25 degrees C, the responses to spinal cooling are reduced during the dark phase.", "output": {"entities": {}}, "schema": []}
{"input": "Ulcer appeared on the angulus of the stomach at the 28th week and resulted in ulcer scar at the 42nd week.", "output": {"entities": {}}, "schema": []}
{"input": "Results of the recognition task revealed significant effects of consonant voicing, position and vowel context on syllable recognition.", "output": {"entities": {}}, "schema": []}
{"input": "Visual response properties of neurons in four extrastriate visual areas of the owl monkey (Aotus trivirgatus): a quantitative comparison of medial, dorsomedial, dorsolateral, and middle temporal areas.", "output": {"entities": {}}, "schema": []}
{"input": "A unified approach to the standardization of allergens.", "output": {"entities": {}}, "schema": []}
{"input": "A dose-dependent fall in GABA content was observed; GABA decrease was evident 15 min after the administration, reached its nadir at 60 min and disappeared at 120 minutes.", "output": {"entities": {}}, "schema": []}
{"input": "For monocytes, as measured on the Hematrak, it was 13. 4%.", "output": {"entities": {}}, "schema": []}
{"input": "Evoked potential and single unit responses to olfactory nerve volleys in the isolated turtle olfactory bulb.", "output": {"entities": {}}, "schema": []}
{"input": "While all deletions within the sequence coding for the mature tRNA led to inactivity of the mutated genes, substitution of the central portion by concatenated Hind III linkers produced gene units active in transcription.", "output": {"entities": {"gene": [{"text": "concatenated Hind III linkers", "start": 146, "end": 175}]}}, "schema": []}
{"input": "Survival was calculated both from the date of onset and from the date of diagnosis.", "output": {"entities": {}}, "schema": []}
{"input": "With Sair and So2, mean vital capacity was reduced by 44% from control.", "output": {"entities": {}}, "schema": []}
{"input": "Of the 117 patients (out of the 136) with serologic evidence of chronic thyroiditis who could be studied, eight (7%) had hyperthyroidism and 45 (38%) were hypothyroid.", "output": {"entities": {}}, "schema": []}
{"input": "The new semi-synthetic oral cephalosporin, CGP 9, 000, has been evaluated in a large number of hospitalized patients with urinary infections.", "output": {"entities": {}}, "schema": []}
{"input": "Current status of chemotherapy for Hodgkin' s disease", "output": {"entities": {}}, "schema": []}
{"input": "Over a period of 15 days 16% of the dose administered was excreted with faeces and 0. 9% in the urine.", "output": {"entities": {}}, "schema": []}
{"input": "Electron microscopic picture of the cerebral cortex in rats cooled to 22 degrees C", "output": {"entities": {}}, "schema": []}
{"input": "Thirty-one age-matched, conscious, virgin, male Sprague-Dawley rats and spontaneously hypertensive rats (SHRs) were individually injected with a single subcutaneous dose of 85 mg/kg dl-isoproterenol to determine the degree and time course of drug-induced cardiac failure and functional recovery.", "output": {"entities": {}}, "schema": []}
{"input": "Prevention of transfusion reactions by the use of saline washed red blood cells.", "output": {"entities": {}}, "schema": []}
{"input": "The geometric mean hemagglutination-inhibition antibody titers (GMT) of non-immunized, once-immunized, and twice-immunized chickens were compared at 2-week intervals following primary immunization, secondary immunization, and challenge.", "output": {"entities": {}}, "schema": []}
{"input": "100 more than in the summer coat).", "output": {"entities": {}}, "schema": []}
{"input": "Two new artifacts in automated coagulation testing.", "output": {"entities": {}}, "schema": []}
{"input": "This relatively simple and easily performed technique of measuring deep muscle temperature appears to be a useful adjunct in choosing the amputation level.", "output": {"entities": {}}, "schema": []}
{"input": "Changes in immunologic reactivity in subjects receiving transfer factor could not be distinguished from those in subjects receiving placebo.", "output": {"entities": {"gene": [{"text": "transfer factor", "start": 56, "end": 71}]}}, "schema": []}
{"input": "Charcoal-facilitated dialysis.", "output": {"entities": {}}, "schema": []}
{"input": "Retinal changes in pigmentary retinopathy in children", "output": {"entities": {}}, "schema": []}
{"input": "As a result, beta-apo-8'-carotenoic acid ethyl ester (apo-EE) was used as a reference standard in Experiments 4 to 6.", "output": {"entities": {}}, "schema": []}
{"input": "Six hours after the last administration, uterus of Gf and Cv mice were weight 337. 6 mg% and 423. 5 mg% respectively, the difference was statistically significant (p less than 0. 01).", "output": {"entities": {}}, "schema": []}
{"input": "Analysis of an autopsy population.", "output": {"entities": {}}, "schema": []}
{"input": "Autoradiographic localisation of its cellular distribution in the kidney.", "output": {"entities": {}}, "schema": []}
{"input": "Microscopic anatomy and cell population dynamics.", "output": {"entities": {}}, "schema": []}
{"input": "In 11 patients with Horton' s headache morphological investigations (differential white blood cell count), cytoenzymatic determinations (alkaline and acid phosphatase, non-specific esterase) and cytoimmunological tests (IgM and IgG binding) were carried out on capillary blood neutrophils obtained from the area of pain, non-painful area of the skin on the head on the contralateral side, and from the finger.", "output": {"entities": {"gene": [{"text": "alkaline and acid phosphatase", "start": 137, "end": 166}, {"text": "non-specific esterase", "start": 168, "end": 189}, {"text": "IgM", "start": 220, "end": 223}, {"text": "IgG", "start": 228, "end": 231}]}}, "schema": []}
{"input": "The resulting R protein terminates five codons downstream of the frameshift site at the V protein stop codon.", "output": {"entities": {"gene": [{"text": "R protein", "start": 14, "end": 23}, {"text": "V protein", "start": 88, "end": 97}]}}, "schema": []}
{"input": "BSE and farmworkers.", "output": {"entities": {}}, "schema": []}
{"input": "Peroxisome proliferator-activated receptors (PPARs) and retinoid X receptors (RXRs) are nuclear hormone receptors that are activated by fatty acids and 9-cis-retinoic acid, respectively.", "output": {"entities": {"gene": [{"text": "Peroxisome proliferator-activated receptors", "start": 0, "end": 43}, {"text": "PPARs", "start": 45, "end": 50}, {"text": "retinoid X receptors", "start": 56, "end": 76}, {"text": "RXRs", "start": 78, "end": 82}, {"text": "nuclear hormone receptors", "start": 88, "end": 113}]}}, "schema": []}
{"input": "The number of lactotropes, somatotropes, thyrotropes, and gonadotropes was not altered compared with controls, indicating that in the adult pituitary, POMC products are not required to maintain the distribution of cell types.", "output": {"entities": {"gene": [{"text": "POMC products", "start": 151, "end": 164}]}}, "schema": []}
{"input": "In electrophoretic mobility shift assays, the PERE formed three major complexes (P1, P2 and P3) with proteins in nuclear extracts from HeLa or 293 cells.", "output": {"entities": {"gene": [{"text": "PERE", "start": 46, "end": 50}]}}, "schema": []}
{"input": "That sequence strongly promoted the transcription of the promotorless chloramphenicol acetyltranferase (CAT) gene in cells of pancreatic origin (AR-42J) but not in cells of non-pancreatic origin (Rat 2 and IEC 6).", "output": {"entities": {"gene": [{"text": "chloramphenicol acetyltranferase", "start": 70, "end": 102}, {"text": "CAT", "start": 104, "end": 107}]}}, "schema": []}
{"input": "In the absence of E1A243, YY1 represses CRE-dependent transcription of c-fos by physically interacting with ATF/CREB proteins bound to the-67 CRE.", "output": {"entities": {"gene": [{"text": "E1A243", "start": 18, "end": 24}, {"text": "YY1", "start": 26, "end": 29}, {"text": "c-fos", "start": 71, "end": 76}, {"text": "ATF", "start": 108, "end": 111}, {"text": "CREB", "start": 112, "end": 116}]}}, "schema": []}
{"input": "TPBF has two potential coiled-coil regions, a basic region, a proline-rich region, a histidine-rich N terminus, and a nuclear targeting sequence.", "output": {"entities": {"gene": [{"text": "TPBF", "start": 0, "end": 4}]}}, "schema": []}
{"input": "To confirm the GapIII protein activity, constructs containing different GapIII-GRD domains were transformed into iral mutant yeast to determine their relative ability to replace IRA1 functionally.", "output": {"entities": {"gene": [{"text": "GapIII protein", "start": 15, "end": 29}, {"text": "GapIII", "start": 72, "end": 78}, {"text": "GRD", "start": 79, "end": 82}, {"text": "iral", "start": 113, "end": 117}, {"text": "IRA1", "start": 178, "end": 182}]}}, "schema": []}
{"input": "A water-vapour giga-maser in the active galaxy TXFS2226-184.", "output": {"entities": {}}, "schema": []}
{"input": "These incisors were studied by scanning electron microscopy-energy dispersive spectroscopy analysis (SEM-EDS) and light microscopy to examine the calciotraumatic lines of strontium in the rat incisor labial dentin.", "output": {"entities": {}}, "schema": []}
{"input": "Mechanism of enhancement of DNA expression consequent to cointernalization of a replication-deficient adenovirus and unmodified plasmid DNA.", "output": {"entities": {}}, "schema": []}
{"input": "Hepatitis B surface antigen was detected in 2 patients, with negative hepatitis C virus antibody.", "output": {"entities": {"gene": [{"text": "Hepatitis B surface antigen", "start": 0, "end": 27}, {"text": "hepatitis C virus antibody", "start": 70, "end": 96}]}}, "schema": []}
{"input": "Liver transplantation in one patient resolved metabolic complications but did not improve PMN count or the infectious status, while neutropenia was corrected by G-CSF.", "output": {"entities": {"gene": [{"text": "G-CSF", "start": 161, "end": 166}]}}, "schema": []}
{"input": "Joys and F.", "output": {"entities": {}}, "schema": []}
{"input": "Tyrosine phosphorylation of cellular proteins is the earliest identifiable event following T-cell antigen receptor (TCR) stimulation and is essential for activating downstream signaling machinery.", "output": {"entities": {"gene": [{"text": "T-cell antigen receptor", "start": 91, "end": 114}, {"text": "TCR", "start": 116, "end": 119}]}}, "schema": []}
{"input": "The interferon-induced RNA-dependent protein kinase (PKR) is considered to play an important role in the cellular defense against viral infection and, in addition, has been suggested to be a tumor suppressor gene because of its growth-suppressive properties.", "output": {"entities": {"gene": [{"text": "interferon", "start": 4, "end": 14}, {"text": "RNA-dependent protein kinase", "start": 23, "end": 51}, {"text": "PKR", "start": 53, "end": 56}]}}, "schema": []}
{"input": "Moreover, Lck was reversibly co-immunoprecipitated with p95Vav, and the stoichiometry of binding increased in anti-CD3-treated Jurkat cells.", "output": {"entities": {"gene": [{"text": "Lck", "start": 10, "end": 13}, {"text": "p95Vav", "start": 56, "end": 62}, {"text": "anti-CD3", "start": 110, "end": 118}]}}, "schema": []}
{"input": "Interleukin-8 (IL-8) is a potent inflammatory mediator that belongs to the family of C-X-C chemokines.", "output": {"entities": {"gene": [{"text": "Interleukin-8", "start": 0, "end": 13}, {"text": "IL-8", "start": 15, "end": 19}, {"text": "C-X-C chemokines", "start": 85, "end": 101}]}}, "schema": []}
{"input": "Three mutants (pms1, pms2 and pms3) isolated earlier from MW104-1B were shown to correct in vitro constructed plasmids with defined DNA mismatches (G/T, A/C, G/G, etc.) poorly (Kramer et al., 1989a).", "output": {"entities": {"gene": [{"text": "pms1", "start": 15, "end": 19}, {"text": "pms2", "start": 21, "end": 25}, {"text": "pms3", "start": 30, "end": 34}]}}, "schema": []}
{"input": "Hematopoietic growth factors are being used to accelerate the recovery of myelopoiesis following high-dose chemotherapy in cancer patients.", "output": {"entities": {"gene": [{"text": "Hematopoietic growth factors", "start": 0, "end": 28}]}}, "schema": []}
{"input": "A particularly striking HpaII tiny fragment island, extending over nearly 2, 000 base pairs, surrounds the USF2 translation initiation site.", "output": {"entities": {"gene": [{"text": "HpaII", "start": 24, "end": 29}, {"text": "USF2 translation initiation site", "start": 107, "end": 139}]}}, "schema": []}
{"input": "Dilutions of H-2b or H-2d NP peptides indicated that 3-4 logs less H-2b NP peptide was required to sensitize syngeneic target cells for CTL-specific lysis, suggesting that the differing affinities of H-2b and H-2d major histocompatibility complex molecules for their peptides likely account for the total removal of NP CTL in the H-2b mice but only partial removal in H-2d mice made to express thymic NP.", "output": {"entities": {"gene": [{"text": "H-2b or H-2d NP peptides", "start": 13, "end": 37}, {"text": "H-2b NP peptide", "start": 67, "end": 82}, {"text": "major histocompatibility complex molecules", "start": 214, "end": 256}]}}, "schema": []}
{"input": "Although both transfected cell lines contain FGF-1 cell surface receptors as judged by crosslinking studies, the wild-type transfectants are refractory to exogenous FGF-1, whereas the mutant transfectants respond normally. (ABSTRACT TRUNCATED AT 250 WORDS)", "output": {"entities": {"gene": [{"text": "FGF-1 cell surface receptors", "start": 45, "end": 73}, {"text": "FGF-1", "start": 165, "end": 170}]}}, "schema": []}
{"input": "The median post-treatment, pre-operative serum PSA was 0. 4 ng/ml.", "output": {"entities": {"gene": [{"text": "serum PSA", "start": 41, "end": 50}]}}, "schema": []}
{"input": "The amino acid sequences of the predicted RfbA and RfbB homologs showed identities of 75. 7% (87. 9% total similarity) and 78. 0% (86. 5% total similarity), respectively.", "output": {"entities": {"gene": [{"text": "RfbA", "start": 42, "end": 46}, {"text": "RfbB homologs", "start": 51, "end": 64}]}}, "schema": []}
{"input": "In this paper we report that ligand binding induced tyrosine phosphorylation in BaF3 cells engineered to express the murine Mpl receptor (BaF3/mMpl).", "output": {"entities": {"gene": [{"text": "murine Mpl receptor", "start": 117, "end": 136}, {"text": "mMpl", "start": 143, "end": 147}]}}, "schema": []}
{"input": "A chicken paxillin cDNA was also cloned and is predicted to encode a protein approximately 90% identical to human paxil-lin.", "output": {"entities": {"gene": [{"text": "chicken paxillin cDNA", "start": 2, "end": 23}, {"text": "human paxil-lin", "start": 108, "end": 123}]}}, "schema": []}
{"input": "In vivo association between Shb-SH3 domain proteins v-Src and Eps8 was detected by coimmunoprecipitation.", "output": {"entities": {"gene": [{"text": "Shb", "start": 28, "end": 31}, {"text": "SH3", "start": 32, "end": 35}, {"text": "v-Src", "start": 52, "end": 57}, {"text": "Eps8", "start": 62, "end": 66}]}}, "schema": []}
{"input": "As expected, the insulin effect to increase ras GTP formation and MAP kinase activity was negligible in A/K1018 cells but normal, or supernormal, in Y/F2 cells.", "output": {"entities": {"gene": [{"text": "insulin", "start": 17, "end": 24}, {"text": "ras GTP", "start": 44, "end": 51}, {"text": "MAP kinase", "start": 66, "end": 76}]}}, "schema": []}
{"input": "Appropriate restriction sites allow one to insert virtually any desired cDNA fragment directly behind the epitope-specific sequence and before a long poly (A) tail.", "output": {"entities": {}}, "schema": []}
{"input": "The gene product of cotS was confirmed to be identical to Cot40-2 by SDS-PAGE and immunoblotting from Escherichia coli transformed with a plasmid containing the cotS region.", "output": {"entities": {"gene": [{"text": "cotS", "start": 20, "end": 24}, {"text": "Cot40-2", "start": 58, "end": 65}, {"text": "cotS region", "start": 161, "end": 172}]}}, "schema": []}
{"input": "The optimal care of CHF patient includes the recognition and management of these electrolyte disturbances.", "output": {"entities": {}}, "schema": []}
{"input": "METHODS: rHb1. 1 or human serum albumin was administered intravenously to fasting male volunteers.", "output": {"entities": {"gene": [{"text": "rHb1. 1", "start": 9, "end": 16}, {"text": "human serum albumin", "start": 20, "end": 39}]}}, "schema": []}
{"input": "A mutant (residues 1-332) showed complete Ca2 +/CaM-dependent activity.", "output": {"entities": {"gene": [{"text": "CaM", "start": 48, "end": 51}]}}, "schema": []}
{"input": "The two bases immediately flanking the 5' end of the element proved to be very important to its function as a UAS element as did the two bases immediately 3' of the bHLH core motif.", "output": {"entities": {}}, "schema": []}
{"input": "These results indicate that the PCNA gene is a likely target gene of E2F.", "output": {"entities": {"gene": [{"text": "PCNA gene", "start": 32, "end": 41}, {"text": "E2F", "start": 69, "end": 72}]}}, "schema": []}
{"input": "Differential sensitivity of the MMPI-2 depression scales and subscales.", "output": {"entities": {}}, "schema": []}
{"input": "The chloramphenicol-resistance transposon Tn4451 undergoes precise conjugative deletion from its parent plasmid plP401 in Clostridium perfringens and precise spontaneous excision from multicopy plasmids in Escherichia coli.", "output": {"entities": {"gene": [{"text": "chloramphenicol-resistance transposon Tn4451", "start": 4, "end": 48}]}}, "schema": []}
{"input": "A general model for ARE-mediated mRNA degradation involving a potential role for certain heterogeneous nuclear ribonucleoproteins and ARE-binding proteins is proposed.", "output": {"entities": {"gene": [{"text": "ARE-binding proteins", "start": 134, "end": 154}]}}, "schema": []}
{"input": "Individual mutations in motifs III, IV, and V had distinctive effects on the affinity of enzyme for GTP, the rate of covalent catalysis (EpG formation), or the transfer of GMP from enzyme to RNA.", "output": {"entities": {}}, "schema": []}
{"input": "Mutational analysis of mRNA capping enzyme identifies amino acids involved in GTP binding, enzyme-guanylate formation, and GMP transfer to RNA.", "output": {"entities": {"gene": [{"text": "mRNA capping enzyme", "start": 23, "end": 42}]}}, "schema": []}
{"input": "Staphylococcal enterotoxin A involvement in the illness of a 20-month-old burn patient.", "output": {"entities": {"gene": [{"text": "Staphylococcal enterotoxin A", "start": 0, "end": 28}]}}, "schema": []}
{"input": "These results suggest that G beta gamma-stimulated Shc phosphorylation represents an early step in the pathway leading to p21ras activation, similar to the mechanism utilized by growth factor tyrosine kinase receptors.", "output": {"entities": {"gene": [{"text": "G beta gamma", "start": 27, "end": 39}, {"text": "Shc", "start": 51, "end": 54}, {"text": "p21ras", "start": 122, "end": 128}, {"text": "growth factor tyrosine kinase receptors", "start": 178, "end": 217}]}}, "schema": []}
{"input": "Negative-staining, refractile mycobacteria in Romanowsky-stained smears.", "output": {"entities": {}}, "schema": []}
{"input": "Here we focused on the role of the 5' proximal regulatory cassette (-190; + 53 bp) of the rat enkephalin (rENK) gene in the developmental regulation of the enkephalin phenotype.", "output": {"entities": {"gene": [{"text": "rat enkephalin", "start": 90, "end": 104}, {"text": "rENK", "start": 106, "end": 110}, {"text": "enkephalin", "start": 156, "end": 166}]}}, "schema": []}
{"input": "Unexpectedly, all ENK-specific motifs formed specific and highly abundant protein-DNA complexes when nuclear extracts from the human tumor cell line (HeLa), which does not express ENK, were used.", "output": {"entities": {"gene": [{"text": "ENK-specific motifs", "start": 18, "end": 37}, {"text": "ENK", "start": 180, "end": 183}]}}, "schema": []}
{"input": "Infant aged 3. 5 years presents persistence of primordial vitreous body with crystalline dislocation in the camera aquosa and secondary buphthalmos of the left eye and microphthalmos with dislocation of the crystalline in the vitreous body of the right eye.", "output": {"entities": {}}, "schema": []}
{"input": "Imaging features of splenic epidermoid cyst with pathologic correlation.", "output": {"entities": {}}, "schema": []}
{"input": "SL1 trans-splicing specified by AU-rich synthetic RNA inserted at the 5' end of Caenorhabditis elegans pre-mRNA.", "output": {"entities": {"gene": [{"text": "SL1", "start": 0, "end": 3}]}}, "schema": []}
{"input": "Overexpression of wild-type p53 also induces apoptosis in an LCL.", "output": {"entities": {"gene": [{"text": "wild-type p53", "start": 18, "end": 31}]}}, "schema": []}
{"input": "These observations lead to the proposal that the RNAP II CTD might be an in vivo target for the activated p42mapk and p44mapk MAP kinases.", "output": {"entities": {"gene": [{"text": "RNAP II CTD", "start": 49, "end": 60}, {"text": "p42mapk", "start": 106, "end": 113}, {"text": "p44mapk MAP kinases", "start": 118, "end": 137}]}}, "schema": []}
{"input": "We also isolated two alternatively spliced forms of human CD6 cDNA lacking sequences encoding membrane-proximal regions of the cytoplasmic domain which maintain the same reading frame as CD6-PB1.", "output": {"entities": {"gene": [{"text": "human CD6 cDNA", "start": 52, "end": 66}, {"text": "CD6", "start": 187, "end": 190}, {"text": "PB1", "start": 191, "end": 194}]}}, "schema": []}
{"input": "We have isolated a Drosophila melanogaster (Dm) cDNA encoding a polypeptide that has extensive sequence similarity to the mammalian MAPKAPK-2.", "output": {"entities": {"gene": [{"text": "mammalian MAPKAPK-2", "start": 122, "end": 141}]}}, "schema": []}
{"input": "A 2. 4-kb MAPKAPK-2 message is expressed throughout development, while two shorter transcripts of 2. 3 and 1. 8 kb appear to be specifically expressed in the germline.", "output": {"entities": {"gene": [{"text": "2. 4-kb MAPKAPK-2 message", "start": 2, "end": 27}]}}, "schema": []}
{"input": "The integrity of the cDNA sequence was confirmed by analysis of several overlapping genomic clones that span the GAR1 gene.", "output": {"entities": {"gene": [{"text": "GAR1 gene", "start": 113, "end": 122}]}}, "schema": []}
{"input": "Phorbol esters stimulated phosphorylation of CSK 35H proteins, thus emphasizing that sequences isolated according to PKC binding activity in vitro are also PKC substrates in vivo.", "output": {"entities": {"gene": [{"text": "CSK 35H proteins", "start": 45, "end": 61}, {"text": "PKC", "start": 117, "end": 120}, {"text": "PKC", "start": 156, "end": 159}]}}, "schema": []}
{"input": "One of these is surrounded by an adenine-uridine rich region that can form an 11-base pair stem structure.", "output": {"entities": {}}, "schema": []}
{"input": "Additionally, the enzyme shows activity towards triglycerides such as olive oil and tributyrin and towards egg-yolk emulsions.", "output": {"entities": {}}, "schema": []}
{"input": "The nucleotide sequence directly upstream of fimA contains two open reading frames, ORF5 and ORF1, whose deduced protein products are homologous to members of a superfamily of ATP-binding cassette membrane transport proteins, including both prokaryotic and eukaryotic uptake and export systems.", "output": {"entities": {"gene": [{"text": "fimA", "start": 45, "end": 49}, {"text": "ATP-binding cassette membrane transport proteins", "start": 176, "end": 224}]}}, "schema": []}
{"input": "The ORF3 probe also hybridized to a 540 bp transcript consistent with the size of ORF3 alone and supportive of the mutagenesis data of non-linkage.", "output": {"entities": {}}, "schema": []}
{"input": "Mean growth changes in this Class II sample were comparable to those previously reported for male subjects with Class I malocclusions over the same age period, suggesting a similarity in postpubertal development between these two groups.", "output": {"entities": {}}, "schema": []}
{"input": "By in vitro immunoprecipitations and gel shift assays, we identified two classes of high affinity Engrailed-binding sites upstream of each of the two polyhomeotic transcription units.", "output": {"entities": {"gene": [{"text": "Engrailed-binding sites", "start": 98, "end": 121}]}}, "schema": []}
{"input": "Subjects with a short postexposure time and a dioxin burden > 0. 6 pg/m3 had a significantly higher risk of hypoergy than unexposed subjects (hypoergy I: OR = 9. 51, 95% CI = 1. 96-42. 02; hypoergy II: OR = 2. 92, 95% CI = 1. 14-7. 5).", "output": {"entities": {}}, "schema": []}
{"input": "Analysis of this sequence combined with that previously reported for the 5'-flanking region directly proximal to the start of transcription revealed several putative regulatory sequences.", "output": {"entities": {}}, "schema": []}
{"input": "The experimental design represents a 2 x 3 factorial arrangement of treatments with three dietary levels of incorporation of RSB (0, 50, and 100%), and chickens either infected or uninfected.", "output": {"entities": {}}, "schema": []}
{"input": "A cDNA clone corresponding to the putative GA 20-oxidase genomic sequence was constructed with the reverse transcription-PCR method, and the identity of the cDNA clone was confirmed by analyzing the capability of the fusion protein expressed in Escherichia coli to convert GA53 to GA44 and GA19 to GA20.", "output": {"entities": {"gene": [{"text": "GA 20", "start": 43, "end": 48}, {"text": "oxidase", "start": 49, "end": 56}, {"text": "GA53", "start": 273, "end": 277}, {"text": "GA44", "start": 281, "end": 285}, {"text": "GA19", "start": 290, "end": 294}, {"text": "GA20", "start": 298, "end": 302}]}}, "schema": []}
{"input": "Total cholesterol was also reduced at week 12 by 17. 0% (20 mg/day) and 15. 7% (20-30 mg/day), and at week 52 by 20. 4% (< or = 20 mg/day) and 19. 2% (> or = 30 mg/day).", "output": {"entities": {}}, "schema": []}
{"input": "Piperacillin-tazobactam can be used for the treatment of infections caused by gram-negative, gram-positive, aerobic, and anaerobic bacteria.", "output": {"entities": {}}, "schema": []}
{"input": "This apparently anomalous structure/activity relationship raises important issues for understanding the evolution of regulatory peptides and the mechanisms that control their expression.", "output": {"entities": {}}, "schema": []}
{"input": "This paper summarises the experimental evidence upon which the clinical trials of aldose reductase inhibitors in diabetic patients have been initiated and the results of published drug trials in these patients.", "output": {"entities": {"gene": [{"text": "aldose reductase", "start": 82, "end": 98}]}}, "schema": []}
{"input": "Increase in urinary calcium and oxalate after fructose infusion.", "output": {"entities": {}}, "schema": []}
{"input": "The Babcock Surgical Clinic.", "output": {"entities": {}}, "schema": []}
{"input": "Histopathological features of relapsed leprosy.", "output": {"entities": {}}, "schema": []}
{"input": "One of these factors, HRF-1, recognizes a cis element consisting of an inverted palindromic motif.", "output": {"entities": {"gene": [{"text": "HRF-1", "start": 22, "end": 27}]}}, "schema": []}
{"input": "Regulation of Gax homeobox gene transcription by a combination of positive factors including myocyte-specific enhancer factor 2.", "output": {"entities": {"gene": [{"text": "Gax homeobox gene", "start": 14, "end": 31}, {"text": "myocyte-specific enhancer factor 2", "start": 93, "end": 127}]}}, "schema": []}
{"input": "The carboxyl-terminal transactivation domain of heat shock factor 1 is negatively regulated and stress responsive.", "output": {"entities": {"gene": [{"text": "heat shock factor 1", "start": 48, "end": 67}]}}, "schema": []}
{"input": "The RAT3 gene encodes an 1157-amino acid protein without similarity to other known proteins.", "output": {"entities": {"gene": [{"text": "RAT3 gene", "start": 4, "end": 13}]}}, "schema": []}
{"input": "CCAAT/enhancer-binding protein isoforms beta and delta are expressed in mammary epithelial cells and bind to multiple sites in the beta-casein gene promoter.", "output": {"entities": {"gene": [{"text": "CCAAT/enhancer-binding protein isoforms beta and delta", "start": 0, "end": 54}, {"text": "beta-casein gene promoter", "start": 131, "end": 156}]}}, "schema": []}
{"input": "We have found that the expression of GTPase-deficient mutants of alpha 12 (alpha 12Q229L) or alpha 13 (alpha 13Q226L) leads to robust activation of the Jun kinase/stress-activated protein kinase (JNK/SAPK) pathway.", "output": {"entities": {"gene": [{"text": "GTPase", "start": 37, "end": 43}, {"text": "alpha 12", "start": 65, "end": 73}, {"text": "alpha 12Q229L", "start": 75, "end": 88}, {"text": "alpha 13", "start": 93, "end": 101}, {"text": "alpha 13Q226L", "start": 103, "end": 116}, {"text": "Jun kinase", "start": 152, "end": 162}, {"text": "stress-activated protein kinase", "start": 163, "end": 194}, {"text": "JNK", "start": 196, "end": 199}, {"text": "SAPK", "start": 200, "end": 204}]}}, "schema": []}
{"input": "Using mutagenesis, we have identified two mutations of the second actin-binding domain that can also suppress the act1 mutations of interest.", "output": {"entities": {"gene": [{"text": "actin-binding domain", "start": 66, "end": 86}, {"text": "act1", "start": 114, "end": 118}]}}, "schema": []}
{"input": "The normal cell cycle is regulated by several molecules, such as the tumor-suppressor protein pRb, the G1 cyclins, the cyclin-dependent kinases, and their inhibitors.", "output": {"entities": {"gene": [{"text": "tumor-suppressor protein pRb", "start": 69, "end": 97}, {"text": "G1 cyclins", "start": 103, "end": 113}, {"text": "cyclin-dependent kinases", "start": 119, "end": 143}]}}, "schema": []}
{"input": "These results are very useful for deciding on the doses of hormones and the expected serum estradiol level in HRT for Japanese women.", "output": {"entities": {}}, "schema": []}
{"input": "Comparison of 1. 5 Tesla and 0. 35 Tesla field strength magnetic resonance imaging scans in the morphometric evaluation of the lumbar intervertebral foramina.", "output": {"entities": {}}, "schema": []}
{"input": "A new vector, pHBK280, was designed to facilitate this analysis.", "output": {"entities": {}}, "schema": []}
{"input": "Here we describe an in vitro assay where the NS3-4A polyprotein, NS3, the serine proteinase domain (the N-terminal 181 residues of NS3), and the NS4A cofactor were produced by cell-free translation and tested for trans-processing of radiolabeled substrates.", "output": {"entities": {"gene": [{"text": "NS3-4A polyprotein", "start": 45, "end": 63}, {"text": "NS3", "start": 65, "end": 68}, {"text": "serine proteinase domain (the N-terminal 181 residues of NS3)", "start": 74, "end": 135}, {"text": "NS4A cofactor", "start": 145, "end": 158}]}}, "schema": []}
{"input": "In contrast, over-expression of RAR beta only poorly restored differentiation, although it could replace RAR gamma for the activation of target genes.", "output": {"entities": {"gene": [{"text": "RAR beta", "start": 32, "end": 40}, {"text": "RAR gamma", "start": 105, "end": 114}]}}, "schema": []}
{"input": "The 5'-terminus of the p-gvpF-M mRNA was located 169 nucleotides upstream of p-gvpF within p-gvpE.", "output": {"entities": {"gene": [{"text": "p-gvpF-M mRNA", "start": 23, "end": 36}, {"text": "p-gvpF", "start": 77, "end": 83}, {"text": "p-gvpE", "start": 91, "end": 97}]}}, "schema": []}
{"input": "However, the relative binding affinity for the motifs is different.", "output": {"entities": {}}, "schema": []}
{"input": "The transport of a genetically engineered chimeric transmembrane protein connected to this ER leader sequence was as efficient as that of the original protein from which the ER sequence has been derived.", "output": {"entities": {}}, "schema": []}
{"input": "A polymorphic bipartite motif signals nuclear targeting of early auxin-inducible proteins related to PS-IAA4 from pea (Pisum sativum).", "output": {"entities": {"gene": [{"text": "PS-IAA4 from pea (Pisum sativum)", "start": 101, "end": 133}]}}, "schema": []}
{"input": "The plant hormone auxin transcriptionally activates early genes.", "output": {"entities": {"gene": [{"text": "early genes", "start": 52, "end": 63}]}}, "schema": []}
{"input": "A new non-LTR retrotransposon provides evidence for multiple distinct site-specific elements in Crithidia fasciculata miniexon arrays.", "output": {"entities": {}}, "schema": []}
{"input": "The CVA16. 4 proteolipid transcript is the most prevalent of the two proteolipid messages in expanding ovules harvested 10 d post-anthesis.", "output": {"entities": {"gene": [{"text": "CVA16. 4 proteolipid transcript", "start": 4, "end": 35}]}}, "schema": []}
{"input": "The synthetic DNA sequence was constructed to achieve efficient base pairing with Escherichia coli 16S ribosomal RNA, avoidance of internal secondary structure, and optimal codon usage for high-level protein expression in accord with the known preferences in E. coli.", "output": {"entities": {"gene": [{"text": "Escherichia coli 16S ribosomal RNA", "start": 82, "end": 116}]}}, "schema": []}
{"input": "Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate the expression of tissue-specific genes in a number of mammalian and insect systems.", "output": {"entities": {}}, "schema": []}
{"input": "EsaR can repress its own expression but seems not to regulate the expression of esaI.", "output": {"entities": {"gene": [{"text": "EsaR", "start": 0, "end": 4}, {"text": "esaI", "start": 80, "end": 84}]}}, "schema": []}
{"input": "We conclude that, in comparison to reports from other regions, Scandinavian renal transplant recipients are at high risk of dying of IHD.", "output": {"entities": {}}, "schema": []}
{"input": "Veterinary certification for livestock export.", "output": {"entities": {}}, "schema": []}
{"input": "Diffuse white matter injury can be attributed to radiation and associated with neurological deficits, but leukoencephalopathy is rarely observed in the absence of chemotherapy.", "output": {"entities": {}}, "schema": []}
{"input": "The ectopic expression of Oct-3/4 in hybrid cells under a constitutive promoter is sufficient for transcriptional activation of an octamer-dependent promoter.", "output": {"entities": {"gene": [{"text": "Oct-3/4", "start": 26, "end": 33}]}}, "schema": []}
{"input": "We here demonstrate that a temperature-sensitive fission yeast mutant which has a mutation in a homologous gene, and two of three additional (mtr1/prp20/srm1) mutants accumulate nuclear poly (A) + RNA at 37 degrees C.", "output": {"entities": {"gene": [{"text": "mtr1", "start": 142, "end": 146}, {"text": "prp20", "start": 147, "end": 152}, {"text": "srm1", "start": 153, "end": 157}]}}, "schema": []}
{"input": "Since RCC1p acts as GNRP for Ran, a small nuclear GTPase of the ras superfamily, we have identified two homologs of Ran in S. cerevisiae (CNR1 and CNR2).", "output": {"entities": {"gene": [{"text": "RCC1p", "start": 6, "end": 11}, {"text": "GNRP", "start": 20, "end": 24}, {"text": "Ran", "start": 29, "end": 32}, {"text": "small nuclear GTPase", "start": 36, "end": 56}, {"text": "ras superfamily", "start": 64, "end": 79}, {"text": "Ran", "start": 116, "end": 119}, {"text": "CNR1", "start": 138, "end": 142}, {"text": "CNR2", "start": 147, "end": 151}]}}, "schema": []}
{"input": "Prostate specific antigen shows the metastatic cases better [correction of worse] than prostatic acid phosphatase.", "output": {"entities": {"gene": [{"text": "Prostate specific antigen", "start": 0, "end": 25}, {"text": "prostatic acid phosphatase", "start": 87, "end": 113}]}}, "schema": []}
{"input": "Of these carriers 149 were diagnosed to be asymptomatic clinically, biochemically and echographically.", "output": {"entities": {}}, "schema": []}
{"input": "Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product.", "output": {"entities": {"gene": [{"text": "proto-oncogene c-kit", "start": 58, "end": 78}, {"text": "c-kit product", "start": 160, "end": 173}]}}, "schema": []}
{"input": "Insulin-like growth factor-binding protein-2 (IGF-BP-2) transcription in rat liver varies with developmental age and fasting.", "output": {"entities": {"gene": [{"text": "Insulin-like growth factor-binding protein-2", "start": 0, "end": 44}, {"text": "IGF-BP-2", "start": 46, "end": 54}]}}, "schema": []}
{"input": "The presence of the RV 5' (+) SL sequence had the primary enhancing effect on translation.", "output": {"entities": {}}, "schema": []}
{"input": "By contrast, all proteins initiated with a methionine placed one residue upstream of the natural N terminus of PR failed to show specific proteolysis.", "output": {"entities": {"gene": [{"text": "PR", "start": 111, "end": 113}]}}, "schema": []}
{"input": "Reverse transcriptase and protease activities of avian leukosis virus Gag-Pol fusion proteins expressed in insect cells.", "output": {"entities": {"gene": [{"text": "Reverse transcriptase", "start": 0, "end": 21}, {"text": "Gag", "start": 70, "end": 73}, {"text": "Pol", "start": 74, "end": 77}]}}, "schema": []}
{"input": "PATIENTS AND METHODS: We report our experience with seven children with active small bowel Crohn' s disease given a casein-based, polymeric feed rich in TGF-beta 2 (Specific Polymeric Diet; Nestle-Clintec; Vevey, Switzerland) as complete nutrition for 8 weeks.", "output": {"entities": {"gene": [{"text": "casein", "start": 116, "end": 122}, {"text": "TGF-beta 2", "start": 153, "end": 163}]}}, "schema": []}
{"input": "The leader sequence of the isolated cDNA clone contains several small open reading frames upstream of the initiation codon of the largest open reading frame coding for the homeodomain protein.", "output": {"entities": {"gene": [{"text": "homeodomain protein", "start": 172, "end": 191}]}}, "schema": []}
{"input": "Experimental adhesion prophylaxis with recombinant tissue plasminogen activator.", "output": {"entities": {"gene": [{"text": "recombinant tissue plasminogen activator", "start": 39, "end": 79}]}}, "schema": []}
{"input": "To determine which sequences in the rat P450c17 promoter may be responsible for basal and cAMP-stimulated gene transcription, deletion constructs containing between-1, 560 and-53 base pairs of 5'-flanking DNA from the rat P450c17 gene were ligated to plasmids expressing the reporter gene luciferase and transfected into two mouse cell lines, adrenal Y-1 cells, and testicular Leydig MA-10 cells.", "output": {"entities": {"gene": [{"text": "rat P450c17 promoter", "start": 36, "end": 56}, {"text": "rat P450c17 gene", "start": 218, "end": 234}, {"text": "luciferase", "start": 289, "end": 299}]}}, "schema": []}
{"input": "We have cloned and sequenced the mouse NMO1 cDNA, which encodes the NAD (P) H: menadione oxidoreductase [also called NAD (P) H: (quinone acceptor) oxidoreductase; quinone reductase; azo dye reductase; DT diaphorase; EC 1. 6. 99. 2].", "output": {"entities": {"gene": [{"text": "mouse NMO1 cDNA", "start": 33, "end": 48}, {"text": "NAD (P) H: menadione oxidoreductase", "start": 68, "end": 103}, {"text": "NAD (P) H: (quinone acceptor) oxidoreductase", "start": 117, "end": 161}, {"text": "quinone reductase", "start": 163, "end": 180}, {"text": "azo dye reductase", "start": 182, "end": 199}, {"text": "DT diaphorase", "start": 201, "end": 214}, {"text": "EC 1. 6. 99. 2", "start": 216, "end": 230}]}}, "schema": []}
{"input": "Mutations in the VPS45 gene, a SEC1 homologue, result in vacuolar protein sorting defects and accumulation of membrane vesicles.", "output": {"entities": {"gene": [{"text": "VPS45 gene", "start": 17, "end": 27}, {"text": "SEC1", "start": 31, "end": 35}]}}, "schema": []}
{"input": "In 293 cells, expression of the NF-kappa B inhibitor, I kappa B-alpha, reduced the stimulatory activity of LMP.", "output": {"entities": {"gene": [{"text": "NF-kappa B", "start": 32, "end": 42}, {"text": "I kappa B-alpha", "start": 54, "end": 69}, {"text": "LMP", "start": 107, "end": 110}]}}, "schema": []}
{"input": "Binding of meAda is necessary to activate transcription of the adaptive response genes; accordingly, in vitro transcription of aidB is dependent on the presence of meAda.", "output": {"entities": {"gene": [{"text": "meAda", "start": 11, "end": 16}, {"text": "aidB", "start": 127, "end": 131}, {"text": "meAda", "start": 164, "end": 169}]}}, "schema": []}
{"input": "No significant differences were identified between groups for pH, PaCO2, intracranial pressure, heart rate, brain temperature, or glucose levels.", "output": {"entities": {}}, "schema": []}
{"input": "Weak allergenicity of recombinant hirudin CGP 39393 (REVASC) in immunocompetent volunteers.", "output": {"entities": {"gene": [{"text": "recombinant hirudin CGP 39393", "start": 22, "end": 51}]}}, "schema": []}
{"input": "Each dietary treatment was fed to six pen replicates of five chicks per pen for 21 d.", "output": {"entities": {}}, "schema": []}
{"input": "The NarX and NarQ proteins with amino acid substitutions at the first conserved histidine position were also unable to dephosphorylate NarL-phosphate in vitro.", "output": {"entities": {"gene": [{"text": "NarX", "start": 4, "end": 8}, {"text": "NarQ proteins", "start": 13, "end": 26}, {"text": "NarL", "start": 135, "end": 139}]}}, "schema": []}
{"input": "The Ng/RC3 and PKC-gamma genes have a similar expression pattern in the brain during development.", "output": {"entities": {"gene": [{"text": "Ng/RC3", "start": 4, "end": 10}, {"text": "PKC-gamma genes", "start": 15, "end": 30}]}}, "schema": []}
{"input": "Structure and regulation of the gene encoding the neuron-specific protein kinase C substrate neurogranin (RC3 protein).", "output": {"entities": {"gene": [{"text": "protein kinase C", "start": 66, "end": 82}, {"text": "neurogranin", "start": 93, "end": 104}, {"text": "RC3 protein", "start": 106, "end": 117}]}}, "schema": []}
{"input": "As in Tb, U6 is a single-copy gene and two tRNA genes, tRNAGln and tRNAIle, are found upstream to the gene.", "output": {"entities": {"gene": [{"text": "U6", "start": 10, "end": 12}, {"text": "tRNAGln", "start": 55, "end": 62}, {"text": "tRNAIle", "start": 67, "end": 74}]}}, "schema": []}
{"input": "2.", "output": {"entities": {}}, "schema": []}
{"input": "Two mammalian enzymes, the haem-controlled repressor (HCR) and the double-stranded RNA-activated inhibitor (dsI), phosphorylate Ser-51 of the alpha subunit, thereby inhibiting the exchange of bound nucleotides on, and thus the recycling of, eIF-2.", "output": {"entities": {"gene": [{"text": "haem-controlled repressor", "start": 27, "end": 52}, {"text": "HCR", "start": 54, "end": 57}, {"text": "double-stranded RNA-activated inhibitor", "start": 67, "end": 106}, {"text": "dsI", "start": 108, "end": 111}, {"text": "eIF-2", "start": 241, "end": 246}]}}, "schema": []}
{"input": "A triple Ser--> Ala mutant form of yeast eIF-2 alpha was found to be no longer phosphorylated by either of the yeast (or mammalian) casein kinase activities in vitro.", "output": {"entities": {"gene": [{"text": "eIF-2 alpha", "start": 41, "end": 52}, {"text": "casein kinase", "start": 132, "end": 145}]}}, "schema": []}
{"input": "Binding activity in rat liver nuclear extracts includes these orphan receptors as judged from electromobility supershift experiments and from results obtained with expressed receptors, although the element in CYP2C11 did not bind HNF-4.", "output": {"entities": {"gene": [{"text": "CYP2C11", "start": 209, "end": 216}, {"text": "HNF-4", "start": 230, "end": 235}]}}, "schema": []}
{"input": "Transcript analysis reveals that lethal B block substitutions reduce U6 RNA synthesis at least 10-fold in vivo and 20-fold in vitro.", "output": {"entities": {"gene": [{"text": "B block", "start": 40, "end": 47}, {"text": "U6 RNA", "start": 69, "end": 75}]}}, "schema": []}
{"input": "Lung function tests (EFR) were performed on these patients for a period of 19. 2 +/-3. 4 months.", "output": {"entities": {}}, "schema": []}
{"input": "Staphylococcus aureus and CNS showed high or moderate resistance rates to methicillin (DMPPC).", "output": {"entities": {}}, "schema": []}
{"input": "Hybridization signals were also detected with total DNAs of Rhizobium leguminosarum bv. phaseoli, Rhodobacter capsulatus and Escherichia coli, but not those of Xanthomonas campestris pv. campestris and Pseudomonas putida.", "output": {"entities": {}}, "schema": []}
{"input": "Serum induction of a MEF2 reporter gene was not observed in a line of NIH 3T3 cells which contain low MEF2 site binding activity.", "output": {"entities": {"gene": [{"text": "MEF2 reporter gene", "start": 21, "end": 39}, {"text": "MEF2 site", "start": 102, "end": 111}]}}, "schema": []}
{"input": "Since AP-1 is an important mediator of tumor promoter action, these findings may explain the anti-tumor-promoting activity of phenolic antioxidants.", "output": {"entities": {"gene": [{"text": "AP-1", "start": 6, "end": 10}]}}, "schema": []}
{"input": "The second complex, when purified, contained four protein components including the 36-kDa protein.", "output": {"entities": {}}, "schema": []}
{"input": "The study was repeated after administration of oral amiodarone, 50 mg/kg/day for 2 days in 8 divided doses (mean dose 6. 9 +/-0. 4 g).", "output": {"entities": {}}, "schema": []}
{"input": "The other two clones, Ash-m and-s, had nucleotide sequences identical with Ash-l cDNA in the amino-terminal region.", "output": {"entities": {"gene": [{"text": "Ash-m and-s", "start": 22, "end": 33}, {"text": "Ash-l", "start": 75, "end": 80}]}}, "schema": []}
{"input": "MATERIAL AND METHODS: Of the 17 men and 17 women, who were 21 to 80 years of age, 27 had hereditary motor and sensory neuropathy type I and 7 had acquired demyelinating polyneuropathy.", "output": {"entities": {}}, "schema": []}
{"input": "Muscle GSH-Px activity after prolonged exercise, training, and selenium supplementation.", "output": {"entities": {"gene": [{"text": "Muscle GSH-Px", "start": 0, "end": 13}]}}, "schema": []}
{"input": "We found that PML was expressed at a lower level in S, G2, and M phases and at a significantly higher level in G1 phase.", "output": {"entities": {"gene": [{"text": "PML", "start": 14, "end": 17}]}}, "schema": []}
{"input": "The roxithromycin doses that were chosen for these studies were less than achievable blood levels.", "output": {"entities": {}}, "schema": []}
{"input": "We demonstrate here that the-DEDDDL sequence stabilizes GDP binding to Ran, and that the domain is required for high affinity interaction with a Ran-binding protein, HTF9A/RanBP1.", "output": {"entities": {"gene": [{"text": "Ran", "start": 71, "end": 74}, {"text": "Ran-binding protein", "start": 145, "end": 164}, {"text": "HTF9A", "start": 166, "end": 171}, {"text": "RanBP1", "start": 172, "end": 178}]}}, "schema": []}
{"input": "Serial followup strength data for 2 patients were compared to change in creatinine kinase (CK) levels.", "output": {"entities": {"gene": [{"text": "creatinine kinase", "start": 72, "end": 89}, {"text": "CK", "start": 91, "end": 93}]}}, "schema": []}
{"input": "Transfection of non-deleted expression vector into NIH3T3 cells results in acquisition of focus-forming activity while a deleted form of expression vector fails to show this activity even in the presence of basic FGF.", "output": {"entities": {"gene": [{"text": "basic FGF", "start": 207, "end": 216}]}}, "schema": []}
{"input": "All ribosomal protein (rp) gene promoters from Saccharomyces cerevisiae studied so far contain either (usually two) binding sites for the global gene regulator Rap1p or one binding site for another global factor, Abf1p.", "output": {"entities": {"gene": [{"text": "ribosomal protein", "start": 4, "end": 21}, {"text": "rp", "start": 23, "end": 25}, {"text": "Rap1p", "start": 160, "end": 165}, {"text": "Abf1p", "start": 213, "end": 218}]}}, "schema": []}
{"input": "CONCLUSION: The MTD for CPT-11 administered in a 3 consecutive-days-every-3 weeks schedule in this patient population is 115 mg/m2/day.", "output": {"entities": {}}, "schema": []}
{"input": "Otte, Mol.", "output": {"entities": {}}, "schema": []}
{"input": "A secondary phosphorylation of CREB341 at Ser129 is required for the cAMP-mediated control of gene expression.", "output": {"entities": {"gene": [{"text": "CREB341", "start": 31, "end": 38}]}}, "schema": []}
{"input": "A role for glycogen synthase kinase-3 in the control of gene expression.", "output": {"entities": {"gene": [{"text": "glycogen synthase kinase-3", "start": 11, "end": 37}]}}, "schema": []}
{"input": "Reconstitution of complexes containing p62 and the src family kinase p59fyn in HeLa cells demonstrated that complex formation resulted in tyrosine phosphorylation of p62 and was mediated by both the SH3 and SH2 domains of p59fyn.", "output": {"entities": {"gene": [{"text": "p62", "start": 39, "end": 42}, {"text": "src family kinase p59fyn", "start": 51, "end": 75}, {"text": "p62", "start": 166, "end": 169}, {"text": "SH3", "start": 199, "end": 202}, {"text": "SH2 domains", "start": 207, "end": 218}, {"text": "p59fyn", "start": 222, "end": 228}]}}, "schema": []}
{"input": "Protein cHMGI binds preferentially to AT-rich DNA with a half-saturation value of 1. 1 nM.", "output": {"entities": {"gene": [{"text": "Protein cHMGI", "start": 0, "end": 13}]}}, "schema": []}
{"input": "The U14 genes of mouse as well as rat, hamster, human, Xenopus and trout are encoded within introns of the constitutively expressed 70-kDa-cognate-heat-shock protein gene (hsc70).", "output": {"entities": {"gene": [{"text": "U14 genes", "start": 4, "end": 13}, {"text": "70-kDa-cognate-heat-shock protein gene", "start": 132, "end": 170}, {"text": "hsc70", "start": 172, "end": 177}]}}, "schema": []}
{"input": "Inclusion in this family of proteins suggests that FliQ and FliR may participate in an export pathway required for flagellum assembly.", "output": {"entities": {"gene": [{"text": "FliQ", "start": 51, "end": 55}, {"text": "FliR", "start": 60, "end": 64}]}}, "schema": []}
{"input": "Coronary vasoconstriction caused by endothelin-1 is enhanced by ischemia-reperfusion and by norepinephrine present in concentrations typically observed after neonatal cardiopulmonary bypass.", "output": {"entities": {"gene": [{"text": "endothelin-1", "start": 36, "end": 48}]}}, "schema": []}
{"input": "Atcys1, Athyp1, AKin10 and the ORF are very close to each other and organized in the same polarity; hence, the intergenic regions probably contain, within less than 0. 5 kb, all the regulatory elements necessary to govern initiation and termination of transcription.", "output": {"entities": {"gene": [{"text": "Atcys1", "start": 0, "end": 6}, {"text": "Athyp1", "start": 8, "end": 14}, {"text": "AKin10", "start": 16, "end": 22}]}}, "schema": []}
{"input": "Southern blot hybridization experiments suggest the presence of one copy of Atcys1, Athyp1 and AKin10 per haploid genome, and Northern blot analysis demonstrates that the three genes are differentially expressed in roots, shoots and leaves.", "output": {"entities": {"gene": [{"text": "Atcys1", "start": 76, "end": 82}, {"text": "Athyp1", "start": 84, "end": 90}, {"text": "AKin10", "start": 95, "end": 101}]}}, "schema": []}
{"input": "Between the subgroups of dementia disorders there were no significant differences in basal cortisol levels.", "output": {"entities": {}}, "schema": []}
{"input": "Basal components of the transcription apparatus (RNA polymerase II, TATA-binding protein) contain activation domains: is the repetitive C-terminal domain (CTD) of RNA polymerase II a \" portable enhancer domain \"? Regions rich in serine, threonine, and proline residues can be found in transcriptional activation domains, as well as in the N-terminal parts of mammalian TATA-binding proteins, where they are interrupted by polyglutamine stretches.", "output": {"entities": {"gene": [{"text": "RNA polymerase II", "start": 49, "end": 66}, {"text": "TATA-binding protein", "start": 68, "end": 88}, {"text": "RNA polymerase II", "start": 163, "end": 180}, {"text": "mammalian TATA-binding proteins", "start": 359, "end": 390}]}}, "schema": []}
{"input": "Mutagenesis of IM1 enhances the ability of c-Fos to activate an AP1 bearing promoter.", "output": {"entities": {"gene": [{"text": "IM1", "start": 15, "end": 18}, {"text": "c-Fos", "start": 43, "end": 48}, {"text": "AP1 bearing promoter", "start": 64, "end": 84}]}}, "schema": []}
{"input": "Self or foreign cellular proteins provide peptides for presentation by major histocompatibility complex (MHC) class I molecules on the surface of antigen presenting cells (APC).", "output": {"entities": {"gene": [{"text": "major histocompatibility complex (MHC) class I molecules", "start": 71, "end": 127}]}}, "schema": []}
{"input": "However, cotransfection studies indicate that RVR does not activate transcription when this hormone response element is linked to a reporter gene but rather acts as a potent competitive repressor of ROR alpha function.", "output": {"entities": {"gene": [{"text": "RVR", "start": 46, "end": 49}, {"text": "ROR alpha", "start": 199, "end": 208}]}}, "schema": []}
{"input": "Molecular cloning and sequencing of a cDNA encoding SR beta revealed that SR beta is a transmembrane protein and, like SR alpha and SRP54, is a member of the GTPase superfamily.", "output": {"entities": {"gene": [{"text": "SR beta", "start": 52, "end": 59}, {"text": "SR beta", "start": 74, "end": 81}, {"text": "SR alpha", "start": 119, "end": 127}, {"text": "SRP54", "start": 132, "end": 137}, {"text": "GTPase superfamily", "start": 158, "end": 176}]}}, "schema": []}
{"input": "To understand the function of receptor-linked tyrosine phosphatases in neural development, we sought to identify LAR isoforms preferentially expressed in the nervous system and cellular processes regulating LAR alternative splicing.", "output": {"entities": {"gene": [{"text": "receptor-linked tyrosine phosphatases", "start": 30, "end": 67}, {"text": "LAR isoforms", "start": 113, "end": 125}, {"text": "LAR", "start": 207, "end": 210}]}}, "schema": []}
{"input": "135 students had a count of less than 50 eggs/10 ml. urine and 56 had more than 50 eggs/10ml.", "output": {"entities": {}}, "schema": []}
{"input": "Chrispeels [1993] EMBO J 12: 2241-2247).", "output": {"entities": {}}, "schema": []}
{"input": "The mRNAs of the GRF genes are encoded by six exons interrupted by five introns.", "output": {"entities": {"gene": [{"text": "GRF genes", "start": 17, "end": 26}]}}, "schema": []}
{"input": "A major task for sports scientists may be to verify empirically the nature of an integrated model of the sport performer.", "output": {"entities": {}}, "schema": []}
{"input": "Removal of the GST domain from GST-Tax by thrombin restores Tax' s ability to assemble a ternary Tax-CREB-21-bp-repeat complex. (ABSTRACT TRUNCATED AT 400 WORDS)", "output": {"entities": {"gene": [{"text": "GST domain", "start": 15, "end": 25}, {"text": "GST", "start": 31, "end": 34}, {"text": "Tax", "start": 35, "end": 38}, {"text": "thrombin", "start": 42, "end": 50}, {"text": "Tax", "start": 60, "end": 63}, {"text": "Tax", "start": 97, "end": 100}, {"text": "CREB", "start": 101, "end": 105}]}}, "schema": []}
{"input": "Specific binding was not observed with either the orthologous rat or mouse fragments using human or rodent extracts.", "output": {"entities": {}}, "schema": []}
{"input": "We have attempted to clone two recessive extragenic suppressors of such ts mutants (sdp1 for mutation pol3-14 and sdp5-1 for mutation pol3-11) by transforming thermoresistant haploid strains pol3-14 sdp1 and pol3-11 sdp5-1 with wild-type genomic libraries in singlecopy or multicopy vectors.", "output": {"entities": {"gene": [{"text": "sdp1", "start": 84, "end": 88}, {"text": "mutation pol3-14", "start": 93, "end": 109}, {"text": "sdp5-1", "start": 114, "end": 120}, {"text": "mutation pol3-11", "start": 125, "end": 141}, {"text": "pol3-14 sdp1", "start": 191, "end": 203}, {"text": "pol3-11 sdp5-1", "start": 208, "end": 222}]}}, "schema": []}
{"input": "In acute-phase livers, we observed a dramatic reduction in HNF-3 alpha expression which correlates with a decrease in the expression of its target gene, the TTR gene.", "output": {"entities": {"gene": [{"text": "HNF-3 alpha", "start": 59, "end": 70}, {"text": "TTR gene", "start": 157, "end": 165}]}}, "schema": []}
{"input": "Similarly, in mammalian cells PBP74 is synthesized as a pre-protein that requires membrane potential-dependent import into mitochondria for its maturation.", "output": {"entities": {"gene": [{"text": "PBP74", "start": 30, "end": 35}]}}, "schema": []}
{"input": "The first open reading frame of the blueberry scorch carlavirus (BBScV) genome encodes a putative replication-associated protein of 223 kDa (p223).", "output": {"entities": {"gene": [{"text": "p223", "start": 141, "end": 145}]}}, "schema": []}
{"input": "From sequence alignments with phylogenetically related viruses, including tymoviruses, we predicted that p223 contained a papain-like proteinase domain with a putative catalytic cysteine994 and histidine1075.", "output": {"entities": {"gene": [{"text": "p223", "start": 105, "end": 109}, {"text": "papain-like proteinase domain", "start": 122, "end": 151}]}}, "schema": []}
{"input": "The p97-depleted nuclei remained largely competent for nuclear protein import.", "output": {"entities": {"gene": [{"text": "p97", "start": 4, "end": 7}]}}, "schema": []}
{"input": "Using gel retardation assays with HepG2 nuclear extract, we demonstrated the presence of a specific protein which bound to the NRE fragment.", "output": {"entities": {}}, "schema": []}
{"input": "Twenty-two consecutive patients with ischaemic ulcers had tcPO2 measured and the ankle/brachial (ABI) and toe/brachial (TBI) indices calculated.", "output": {"entities": {}}, "schema": []}
{"input": "TcPO2 measurement appears to be a reliable technique that can influence ischaemic ulcer management.", "output": {"entities": {}}, "schema": []}
{"input": "Expression of h6. 1 in COS-1 cells led to the production of a typical type IV PDE activity in that cAMP, but not cGMP, served as substrate and its activity was insensitive to either Ca2 +/CaM or cGMP but was inhibited by low concentrations of rolipram. (ABSTRACT TRUNCATED AT 400 WORDS)", "output": {"entities": {"gene": [{"text": "type IV PDE", "start": 70, "end": 81}, {"text": "CaM", "start": 188, "end": 191}]}}, "schema": []}
{"input": "The PSD2 gene was heterologously expressed by infection of Sf-9 insect cells with recombinant baculovirus, resulting in a 10-fold increase in PSD activity.", "output": {"entities": {"gene": [{"text": "PSD2 gene", "start": 4, "end": 13}, {"text": "PSD", "start": 142, "end": 145}]}}, "schema": []}
{"input": "Like Epo, HNF-4 is expressed in kidney, liver, and Hep3B cells but not in HeLa cells.", "output": {"entities": {"gene": [{"text": "Epo", "start": 5, "end": 8}, {"text": "HNF-4", "start": 10, "end": 15}]}}, "schema": []}
{"input": "Moreover, the hypoxia-induced expression of the endogenous Epo gene was significantly inhibited in Hep3B cells stably transfected with HNF-4 delta C.", "output": {"entities": {"gene": [{"text": "Epo gene", "start": 59, "end": 67}, {"text": "HNF-4 delta C", "start": 135, "end": 148}]}}, "schema": []}
{"input": "These observations indicate that there are multiple mechanisms by which an individual transcript can be degraded following deadenylation.", "output": {"entities": {}}, "schema": []}
{"input": "Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor.", "output": {"entities": {"gene": [{"text": "Small Maf proteins", "start": 0, "end": 18}, {"text": "Fos", "start": 39, "end": 42}, {"text": "NF-E2 transcription factor", "start": 88, "end": 114}]}}, "schema": []}
{"input": "Both factors demonstrated significant correlations with rCBF in the medial prefrontal cortex and frontal polar cortex while for each factor there were also unique patterns of correlations with posterior brain regions.", "output": {"entities": {}}, "schema": []}
{"input": "The resulting integrated physical, genetic, and cytogenetic map constitutes a resource for the characterization of genes that may be involved in the WAGR syndrome.", "output": {"entities": {}}, "schema": []}
{"input": "Three classes of test objects were considered: (1) a multicompartment test object for 31P MRS measurements performed with slice-selective sequences; (2) a two-compartment test object for volume-selection 1H MRS; and (3) two-compartment test objects for assessing the performance of experimental systems using ISIS as volume localization sequence in 31P MRS.", "output": {"entities": {}}, "schema": []}
{"input": "Pregnancy screening by uterine artery Doppler velocimetry--which criterion performs best? OBJECTIVE: To test whether repeating Doppler studies of the uteroplacental circulation late in gestation will improve the test' s power for predicting pregnancy-induced hypertension and fetal growth restriction (FGR), and whether analysis based on a combination of quantitative and qualitative assessments of the uterine arterial waveforms will yield better results than analysis based on either alone.", "output": {"entities": {}}, "schema": []}
{"input": "Analysis of disassociation rates indicates that the Grf10-Swi5-DNA complex has a longer half-life than protein-DNA complexes that contain only Swi5 or Grf10.", "output": {"entities": {"gene": [{"text": "Grf10", "start": 52, "end": 57}, {"text": "Swi5", "start": 58, "end": 62}, {"text": "Swi5", "start": 143, "end": 147}, {"text": "Grf10", "start": 151, "end": 156}]}}, "schema": []}
{"input": "The mutant allele of the alpha 1-tubulin gene was designated tua1-1.", "output": {"entities": {"gene": [{"text": "alpha 1-tubulin gene", "start": 25, "end": 45}, {"text": "tua1-1", "start": 61, "end": 67}]}}, "schema": []}
{"input": "Analysis of a set of deletion constructs in transient transfection assays measuring heterologous reporter gene (luciferase) activity demonstrated that the 182-bp 5'-flanking region provides full promoter activity in IL-2-stimulated L2 cells.", "output": {"entities": {"gene": [{"text": "luciferase", "start": 112, "end": 122}, {"text": "IL-2", "start": 216, "end": 220}]}}, "schema": []}
{"input": "Northern analysis of RNA samples isolated from ammonium-grown cultures of the ntcA mutant showed reduced amounts of glnA message and the absence of a 1. 7-kb transcript.", "output": {"entities": {"gene": [{"text": "ntcA mutant", "start": 78, "end": 89}, {"text": "glnA message", "start": 116, "end": 128}]}}, "schema": []}
{"input": "In order to define potential candidate genes for inherited disorders characterized by aberrant gene expression, we utilized Kruppel-related sequences to isolate zinc finger-containing cDNAs.", "output": {"entities": {"gene": [{"text": "Kruppel-related sequences", "start": 124, "end": 149}]}}, "schema": []}
{"input": "The isolated POT1 clones hybridized to a 1. 4 kb RNA species, which was induced approximately 30-fold when oleate was the carbon source.", "output": {"entities": {"gene": [{"text": "POT1", "start": 13, "end": 17}]}}, "schema": []}
{"input": "The Y. lipolytica genomic POT1 gene was disrupted by replacing 120 bp of its coding sequence with 2. 7 kbp of DNA including the Y. lipolytica LEU2 gene.", "output": {"entities": {"gene": [{"text": "POT1", "start": 26, "end": 30}, {"text": "LEU2 gene", "start": 142, "end": 151}]}}, "schema": []}
{"input": "The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium.", "output": {"entities": {"gene": [{"text": "Notch homologue mouse Notch 3", "start": 10, "end": 39}, {"text": "epidermal growth factor-repeats", "start": 55, "end": 86}]}}, "schema": []}
{"input": "Immunoreactive AR content in transfected COS-1 cells was not influenced by exposure to 8-Br-cAMP.", "output": {"entities": {"gene": [{"text": "AR", "start": 15, "end": 17}]}}, "schema": []}
{"input": "Internal biliary drainage, unlike external drainage, does not suppress the regeneration of cholestatic rat liver after partial hepatectomy.", "output": {"entities": {}}, "schema": []}
{"input": "ORF 2 potentially encoded a hydrophobic protein of 29, 705 Da with six potential membrane-spanning regions.", "output": {"entities": {}}, "schema": []}
{"input": "Plasmids were constructed with the mouse promoter region linked to the reporter gene chloramphenicol acetyltransferase (CAT), and transiently and stably transfected in the INS-1 cells.", "output": {"entities": {"gene": [{"text": "reporter gene chloramphenicol acetyltransferase", "start": 71, "end": 118}, {"text": "CAT", "start": 120, "end": 123}]}}, "schema": []}
{"input": "Specifically, this study determined the influence of: (1) an awareness strategy, (2) a non-awareness strategy, (3) a Five-Step Approach strategy and (4) a control condition.", "output": {"entities": {}}, "schema": []}
{"input": "Mutually exclusive interaction of the adenovirus E4-6/7 protein and the retinoblastoma gene product with internal domains of E2F-1 and DP-1.", "output": {"entities": {"gene": [{"text": "adenovirus E4-6/7 protein", "start": 38, "end": 63}, {"text": "retinoblastoma gene product", "start": 72, "end": 99}, {"text": "E2F-1", "start": 125, "end": 130}, {"text": "DP-1", "start": 135, "end": 139}]}}, "schema": []}
{"input": "The transverse magnetization decays mentioned above exhibited two components, a T2 fast (T2f) and a T2 slow (T2s) component.", "output": {"entities": {}}, "schema": []}
{"input": "Expression of a dominant-negative ras gene also blocks TIS10/PGS2 induction by v-src.", "output": {"entities": {"gene": [{"text": "dominant-negative ras gene", "start": 16, "end": 42}, {"text": "TIS10", "start": 55, "end": 60}, {"text": "PGS2", "start": 61, "end": 65}, {"text": "v-src", "start": 79, "end": 84}]}}, "schema": []}
{"input": "Human T-cell leukemia virus type I Tax activation of NF-kappa B/Rel involves phosphorylation and degradation of I kappa B alpha and RelA (p65)-mediated induction of the c-rel gene.", "output": {"entities": {"gene": [{"text": "Tax", "start": 35, "end": 38}, {"text": "NF-kappa B", "start": 53, "end": 63}, {"text": "Rel", "start": 64, "end": 67}, {"text": "I kappa B alpha", "start": 112, "end": 127}, {"text": "RelA (p65)", "start": 132, "end": 142}, {"text": "c-rel gene", "start": 169, "end": 179}]}}, "schema": []}
{"input": "These RZR subtypes represent members of a new family of orphan nuclear receptors that most likely regulate specific gene expression.", "output": {"entities": {"gene": [{"text": "RZR", "start": 6, "end": 9}, {"text": "orphan nuclear receptors", "start": 56, "end": 80}]}}, "schema": []}
{"input": "Interestingly, these response elements display dramatically reduced affinity for retinoic acid receptor-retinoid-X receptor heterodimers.", "output": {"entities": {"gene": [{"text": "retinoic acid receptor", "start": 81, "end": 103}, {"text": "retinoid-X receptor", "start": 104, "end": 123}]}}, "schema": []}
{"input": "Remarkably, U21 contains a long stretch (13 nt.) of complementarity to a highly conserved sequence in 28S rRNA.", "output": {"entities": {"gene": [{"text": "U21", "start": 12, "end": 15}, {"text": "28S rRNA", "start": 102, "end": 110}]}}, "schema": []}
{"input": "These results provide evidence of a bypass of p53-induced Waf1/Cip1-mediated cell cycle regulatory pathways by a member of the myb oncogene family.", "output": {"entities": {"gene": [{"text": "p53", "start": 46, "end": 49}, {"text": "Waf1", "start": 58, "end": 62}, {"text": "Cip1", "start": 63, "end": 67}, {"text": "myb oncogene family", "start": 127, "end": 146}]}}, "schema": []}
{"input": "All groups were challenged subsequently with naloxone (0. 4 mg/kg) in the distinctive environment and then observed for signs of opiate withdrawal.", "output": {"entities": {}}, "schema": []}
{"input": "There were 9 patients in NYHA class III and 8 in class IV. (ABSTRACT TRUNCATED AT 250 WORDS)", "output": {"entities": {}}, "schema": []}
{"input": "TG-day and TG-night were 19. 4 +/-6. 1%, 26. 6 +/-5. 3%, (750 mm3 < T.", "output": {"entities": {}}, "schema": []}
{"input": "Ten volunteers were tested at 18, 000 ft (5, 486 m), and through 12, 000, 8, 000, and 5, 000 ft (3, 657, 2, 438, and 1, 524 m) with directional sounds recorded via a dummy head microphone and presented binaurally.", "output": {"entities": {}}, "schema": []}
{"input": "Upon differentiation with retinoic acid (RA), transcription of the Rex-1 gene decreases rapidly.", "output": {"entities": {"gene": [{"text": "Rex-1 gene", "start": 67, "end": 77}]}}, "schema": []}
{"input": "In general, the filtration rate in relevant areas appears to be an integrative and easily determined parameter, reflecting hormonal and neurogenic vascular as well as local interstitial control of the Starling forces.", "output": {"entities": {}}, "schema": []}
{"input": "Homozygous null embryos also displayed abnormalities in heart development, consistent with the conclusion that Tek is necessary for endocardial/myocardial interactions during development.", "output": {"entities": {"gene": [{"text": "Tek", "start": 111, "end": 114}]}}, "schema": []}
{"input": "A strong trithorax binding site was found at the cytological location of the fork head gene, a region-specific homeotic gene not located within a homeotic complex.", "output": {"entities": {"gene": [{"text": "trithorax binding site", "start": 9, "end": 31}, {"text": "fork head gene", "start": 77, "end": 91}, {"text": "homeotic gene", "start": 111, "end": 124}, {"text": "homeotic complex", "start": 146, "end": 162}]}}, "schema": []}
{"input": "C/EBP alpha also activates the promoter of the rat class-I ADH gene in a sequence-specific manner [Potter et al., Arch.", "output": {"entities": {"gene": [{"text": "C/EBP alpha", "start": 0, "end": 11}, {"text": "rat class-I ADH gene", "start": 47, "end": 67}]}}, "schema": []}
{"input": "C/EBP alpha also activates the promoter of the rat class-I ADH gene in a sequence-specific manner [Potter et al., Arch.", "output": {"entities": {"gene": [{"text": "C/EBP alpha", "start": 0, "end": 11}, {"text": "rat class-I ADH gene", "start": 47, "end": 67}]}}, "schema": []}
{"input": "Segments with more reduced BMIPP uptake than MIBI uptake (mismatching) showed either normal wall motion or demonstrated inotropic reserve during dobutamine stimulation.", "output": {"entities": {}}, "schema": []}
{"input": "The present data also indicate that patients with TGBM nephropathy often have concomitant IgA nephropathy and mesangial proliferative glomerulonephritis.", "output": {"entities": {"gene": [{"text": "IgA", "start": 90, "end": 93}]}}, "schema": []}
{"input": "A full-length cDNA clone isolated from a rat lung library was predicted to encode a 55-kDa protein containing at its amino terminus a targeting domain that binds to the ANP-receptor kinase-like domain and containing at its carboxyl terminus a putative protein-serine phosphatase domain.", "output": {"entities": {"gene": [{"text": "ANP-receptor kinase-like domain", "start": 169, "end": 200}, {"text": "protein-serine phosphatase", "start": 252, "end": 278}]}}, "schema": []}
{"input": "A high-resolution restriction map of over 200 kb of contiguous DNA containing N-myc has been generated by subcloning YACs into cosmids.", "output": {"entities": {"gene": [{"text": "N-myc", "start": 78, "end": 83}]}}, "schema": []}
{"input": "In the present article, the causes of death or ill-being as found in 10 consecutive carcinogenicity studies--5 studies with 2400 OFA (Sprague-Dawley-derived) and Wistar rats and 5 studies with 2400 OF1 and NMRI mice--were re-examined.", "output": {"entities": {}}, "schema": []}
{"input": "Surprisingly, Northern (RNA) blot analysis and reverse transcriptase-PCRs performed after transfection of COS-7 or HeLa cells with these viral RNAs revealed that Y88S and Y88L RNAs replicated at only very low levels.", "output": {"entities": {"gene": [{"text": "reverse transcriptase", "start": 47, "end": 68}, {"text": "Y88S", "start": 162, "end": 166}, {"text": "Y88L RNAs", "start": 171, "end": 180}]}}, "schema": []}
{"input": "Moreover, the ability to selectivity arrest elongation by polIII at defined positions within the tRNA gene transcription unit has permitted the identification of discrete functional properties of paused mammalian polIII ternary complexes.", "output": {"entities": {"gene": [{"text": "polIII", "start": 58, "end": 64}, {"text": "mammalian polIII ternary complexes", "start": 203, "end": 237}]}}, "schema": []}
{"input": "A recent index (Fluorosis Risk Index) developed by Pendrys (1990) is also included in this review.", "output": {"entities": {}}, "schema": []}
{"input": "The role of HIV tat, which is the main enhancing factor for viral LTR, in the regulation of IL-2 gene transcription has been studied following transient expression of the tat gene in phorbol ester and calcium ionophore-activated Jurkat cells transfected with IL-2 promoter-chloramphenicol acetyltransferase reporter constructs.", "output": {"entities": {"gene": [{"text": "HIV tat", "start": 12, "end": 19}, {"text": "viral LTR", "start": 60, "end": 69}, {"text": "IL-2 gene", "start": 92, "end": 101}, {"text": "tat gene", "start": 171, "end": 179}, {"text": "IL-2", "start": 259, "end": 263}, {"text": "chloramphenicol acetyltransferase", "start": 273, "end": 306}]}}, "schema": []}
{"input": "Splice variations in genes coding for the transmembrane FGF receptor (FGFR) result in isoforms that vary in the ectodomain, intracellular juxtamembrane domain, and the intracellular kinase domain.", "output": {"entities": {"gene": [{"text": "transmembrane FGF receptor", "start": 42, "end": 68}, {"text": "FGFR", "start": 70, "end": 74}]}}, "schema": []}
{"input": "The git1, git3, git5, git7, git8 and git10 genes act upstream of adenylate cyclase, presumably encoding an adenylate cyclase activation pathway.", "output": {"entities": {"gene": [{"text": "git1", "start": 4, "end": 8}, {"text": "git3", "start": 10, "end": 14}, {"text": "git5", "start": 16, "end": 20}, {"text": "git7", "start": 22, "end": 26}, {"text": "git8", "start": 28, "end": 32}, {"text": "git10 genes", "start": 37, "end": 48}, {"text": "adenylate cyclase", "start": 65, "end": 82}, {"text": "adenylate cyclase", "start": 107, "end": 124}]}}, "schema": []}
{"input": "Deletion studies identified a distal response element that is responsible for the cytokine response and has properties of an inducible transcriptional enhancer.", "output": {"entities": {}}, "schema": []}
{"input": "No drop in oxygen saturation (SaO2) or visual evidence of transient electroencephalographic (EEG) arousals can be found at repeat polysomnography.", "output": {"entities": {}}, "schema": []}
{"input": "This sequenced region of the V beta locus contains an average number of repetitive DNA elements (21 Alu, three L1, three MER, and three retrovirus-related elements.", "output": {"entities": {"gene": [{"text": "Alu", "start": 100, "end": 103}, {"text": "L1", "start": 111, "end": 113}]}}, "schema": []}
{"input": "However, by an NS35-specific RNA capture assay, the multimers were shown to possess the RNA-binding activity previously demonstrated for NS35.", "output": {"entities": {"gene": [{"text": "NS35-specific RNA", "start": 15, "end": 32}, {"text": "NS35", "start": 137, "end": 141}]}}, "schema": []}
{"input": "Ketamine in the treatment of bronchospasm during mechanical ventilation.", "output": {"entities": {}}, "schema": []}
{"input": "The molecular basis for commitment of progenitors to the eosinophil lineage and mechanisms by which eosinophil-specific genes are expressed and regulated during differentiation is unknown.", "output": {"entities": {}}, "schema": []}
{"input": "Thus, YMIP is a functional homolog of RMIP and represents a new component of the yeast mitochondrial import machinery.", "output": {"entities": {"gene": [{"text": "YMIP", "start": 6, "end": 10}, {"text": "RMIP", "start": 38, "end": 42}]}}, "schema": []}
{"input": "Tryptic cleavage and peptide sequence analysis demonstrated that the 98-kD protein is identical to a recently cloned protein, special A-T-rich binding protein 1 (SATB1), that binds selectively to nuclear matrix/scaffold-associated regions of DNA (MARs/SARs).", "output": {"entities": {"gene": [{"text": "special A-T-rich binding protein 1", "start": 126, "end": 160}, {"text": "SATB1", "start": 162, "end": 167}]}}, "schema": []}
{"input": "Heparin had no effect on rAC-st myosin light chain phosphatase activity, while the B subunit-containing forms were stimulated 2-3-fold.", "output": {"entities": {"gene": [{"text": "rAC-st myosin light chain phosphatase", "start": 25, "end": 62}]}}, "schema": []}
{"input": "BACKGROUND AND DESIGN: Fifty-nine melanocytic nevi with eccentric foci of hyperpigmentation (\" small dark dots \") that measured primarily 1 to 2 mm in diameter were prospectively examined to determine the histologic correlates of the dark dots.", "output": {"entities": {}}, "schema": []}
{"input": "A single NMSC was present in 69. 4%, two in 16%, three in 6. 4%, four in 3. 5%, five to nine in 4. 2%, and 0. 5% had ten or more.", "output": {"entities": {}}, "schema": []}
{"input": "The two ParA proteins that are produced as a result of independent translation initiation at two different start codons within the same open reading frame were overexpressed in Escherichia coli and partially purified.", "output": {"entities": {"gene": [{"text": "ParA proteins", "start": 8, "end": 21}]}}, "schema": []}
{"input": "To get further insights into the molecular mechanisms that control tal-1 expression, we have isolated 5' sequences of the murine gene and compared them to their human counterparts.", "output": {"entities": {"gene": [{"text": "tal-1", "start": 67, "end": 72}]}}, "schema": []}
{"input": "These results demonstrate that a diverse set of carboxyl-terminal sequence motifs and posttranslational modifications lead to functional Ras proteins in yeast.", "output": {"entities": {"gene": [{"text": "Ras proteins", "start": 137, "end": 149}]}}, "schema": []}
{"input": "Binding of U2 small nuclear ribonucleoprotein (snRNP) to the pre-mRNA is an early and important step in spliceosome assembly.", "output": {"entities": {"gene": [{"text": "U2 small nuclear ribonucleoprotein", "start": 11, "end": 45}]}}, "schema": []}
{"input": "Our results indicate that the KRAB domain present in the non-finger region of many ZFP genes quenches transcription possibly due to specific protein-protein interactions between the KRAB-A domain and components of the proximal transcriptional apparatus.", "output": {"entities": {"gene": [{"text": "KRAB domain", "start": 30, "end": 41}, {"text": "ZFP genes", "start": 83, "end": 92}, {"text": "KRAB-A domain", "start": 182, "end": 195}]}}, "schema": []}
{"input": "Marine oils and cardiovascular reactivity.", "output": {"entities": {}}, "schema": []}
{"input": "Significant alterations in CBC results and serum CRP concentration, compared with baseline values, were lacking in dogs of the control group.", "output": {"entities": {"gene": [{"text": "serum CRP", "start": 43, "end": 52}]}}, "schema": []}
{"input": "The newly recognised skeletogenital syndrome.", "output": {"entities": {}}, "schema": []}
{"input": "Ras-and ultra-violet-responsive protein kinases that phosphorylate c-Jun on serine residues at positions 63 and 73 and stimulate its transcriptional activity have been identified.", "output": {"entities": {"gene": [{"text": "Ras-and ultra-violet-responsive protein kinases", "start": 0, "end": 47}, {"text": "c-Jun", "start": 67, "end": 72}]}}, "schema": []}
{"input": "A short sequence surrounding the major JNK phosphorylation site of c-Jun is conserved in c-Fos and is part of its activation domain, suggesting that c-Fos may be similarly regulated.", "output": {"entities": {"gene": [{"text": "JNK", "start": 39, "end": 42}, {"text": "c-Jun", "start": 67, "end": 72}, {"text": "c-Fos", "start": 89, "end": 94}, {"text": "c-Fos", "start": 149, "end": 154}]}}, "schema": []}
{"input": "c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK.", "output": {"entities": {"gene": [{"text": "c-Fos", "start": 0, "end": 5}, {"text": "H-Ras-activated protein kinase", "start": 45, "end": 75}, {"text": "JNK", "start": 90, "end": 93}, {"text": "ERK", "start": 98, "end": 101}]}}, "schema": []}
{"input": "Essential features of this model are bending of the DNA double helix and contact of operator sites with repressor domains bearing sequence homologies with the helix-turn-helix (HTH) motifs of other DNA-binding proteins.", "output": {"entities": {}}, "schema": []}
{"input": "The binding of transcription factor AP-1 and vitamin D receptor (VDR) to the composite AP-1 plus vitamin-D-responsive promoter region (AP-1 + VDRE) of the human osteocalcin gene was characterized in osteocalcin-producing (MG-63) and non-producing (U2-Os, SaOs-2) human osteosarcoma cell lines.", "output": {"entities": {"gene": [{"text": "AP-1", "start": 36, "end": 40}, {"text": "vitamin D receptor", "start": 45, "end": 63}, {"text": "VDR", "start": 65, "end": 68}, {"text": "AP-1 plus vitamin-D-responsive promoter", "start": 87, "end": 126}, {"text": "AP-1 + VDRE", "start": 135, "end": 146}, {"text": "human osteocalcin gene", "start": 155, "end": 177}, {"text": "osteocalcin", "start": 199, "end": 210}]}}, "schema": []}
{"input": "2.", "output": {"entities": {}}, "schema": []}
{"input": "The LTR-binding activities of VBP, a1/EBP, and B-cell nuclear extract protein were compared and mapped by gel shift, DNase I footprinting, and methylation interference assays.", "output": {"entities": {"gene": [{"text": "VBP", "start": 30, "end": 33}, {"text": "a1/EBP", "start": 35, "end": 41}, {"text": "B-cell nuclear extract protein", "start": 47, "end": 77}, {"text": "DNase I", "start": 117, "end": 124}]}}, "schema": []}
{"input": "These results suggest that leader-mRNA fusion in coronavirus transcription does not require direct RNA-RNA interaction between complementary sequences.", "output": {"entities": {}}, "schema": []}
{"input": "These results suggest that leader-mRNA fusion in coronavirus transcription does not require direct RNA-RNA interaction between complementary sequences.", "output": {"entities": {}}, "schema": []}
{"input": "To determine whether P35 could activate the 39k promoter in the absence of IE1, the p35 open reading frame was cloned under the control of the ie1 promoter.", "output": {"entities": {"gene": [{"text": "P35", "start": 21, "end": 24}, {"text": "IE1", "start": 75, "end": 78}, {"text": "p35", "start": 84, "end": 87}, {"text": "ie1 promoter", "start": 143, "end": 155}]}}, "schema": []}
{"input": "In addition, a microsatellite repeat polymorphism with a heterozygosity of 71% at the RET locus and a restriction fragment length polymorphism with a heterozygosity of 42% detected by a lambda clone from the D10S94 locus have been developed for high-resolution genetic linkage mapping and predictive diagnostic testing.", "output": {"entities": {"gene": [{"text": "RET locus", "start": 86, "end": 95}, {"text": "D10S94 locus", "start": 208, "end": 220}]}}, "schema": []}
{"input": "However, tyrA can be expressed efficiently from an internal promoter which appears to lie within the 3' portion of aroF.", "output": {"entities": {"gene": [{"text": "tyrA", "start": 9, "end": 13}, {"text": "aroF", "start": 115, "end": 119}]}}, "schema": []}
{"input": "Within the span of attenuator region encoding the three stem-loop structures of mRNA secondary configuration, hot spots of base-residue divergence were localized to looped-out regions.", "output": {"entities": {}}, "schema": []}
{"input": "Previous studies showed that mutations in the 6K protein led to the slow release of aberrant, multi-cored infectious virions.", "output": {"entities": {}}, "schema": []}
{"input": "The RFLP patterns of the isolates from six of these patients remained essentially unchanged (two strains showed one additional band) despite the development of drug resistance.", "output": {"entities": {}}, "schema": []}
{"input": "Southern analysis on genomic DNA isolated from tissues and cell lines from several mouse strains using mCD22 cDNA demonstrated that the Cd22 locus encoding mCD22 is a single copy gene of < or = 30 kb.", "output": {"entities": {"gene": [{"text": "mCD22 cDNA", "start": 103, "end": 113}, {"text": "Cd22 locus", "start": 136, "end": 146}, {"text": "mCD22", "start": 156, "end": 161}]}}, "schema": []}
{"input": "The tyrosine hydroxylase gene (TH) contains a single copy of a consensus CRE at-45 to-38 base pair (bp) upstream of the transcription initiation site.", "output": {"entities": {"gene": [{"text": "tyrosine hydroxylase gene", "start": 4, "end": 29}, {"text": "TH", "start": 31, "end": 33}]}}, "schema": []}
{"input": "Fenoldopam, a dopamine receptor agonist, has been shown, in animal experiments, to improve renal perfusion.", "output": {"entities": {"gene": [{"text": "dopamine receptor", "start": 14, "end": 31}]}}, "schema": []}
{"input": "The results indicate that hrpRS and hrpL are part of a regulatory cascade in which HrpR and HrpS activate expression of hrpL and HrpL, a putative sigma factor, induces expression of HrpL-responsive genes.", "output": {"entities": {"gene": [{"text": "hrpRS", "start": 26, "end": 31}, {"text": "hrpL", "start": 36, "end": 40}, {"text": "HrpR", "start": 83, "end": 87}, {"text": "HrpS", "start": 92, "end": 96}, {"text": "hrpL", "start": 120, "end": 124}, {"text": "HrpL", "start": 129, "end": 133}, {"text": "sigma factor", "start": 146, "end": 158}, {"text": "HrpL-responsive genes", "start": 182, "end": 203}]}}, "schema": []}
{"input": "All other normal and transformed lymphoid and nonlymphoid cell lines and normal tissues were negative for PANG expression except for the brain, wherein unique 4. 0-and 6. 1-kb transcripts were detected.", "output": {"entities": {"gene": [{"text": "PANG", "start": 106, "end": 110}]}}, "schema": []}
{"input": "L., Greer, J. & Carter, G.", "output": {"entities": {}}, "schema": []}
{"input": "Western blotting (immunoblotting) with an antiserum to a partial SOD expressed in Escherichia coli revealed two proteins with estimated molecular masses of 19 and 29 kDa.", "output": {"entities": {"gene": [{"text": "SOD", "start": 65, "end": 68}]}}, "schema": []}
{"input": "Members of the myocyte-specific enhancer-binding factor 2 (MEF2) family of transcription factors bind a conserved A/T-rich sequence in the control regions of numerous muscle-specific genes.", "output": {"entities": {"gene": [{"text": "myocyte-specific enhancer-binding factor 2", "start": 15, "end": 57}, {"text": "MEF2", "start": 59, "end": 63}]}}, "schema": []}
{"input": "Seven of these had counterparts in the US of herpes simplex type 1 (HSV-1), pseudorabies virus (PRV), and equine herpesvirus type 1 (EHV-1).", "output": {"entities": {}}, "schema": []}
{"input": "The previously described enhanced translation of spinach L12 mRNA from its two tandem AUG codons and the two functional rpl12 genes in Arabidopsis probably provide two mechanisms for generating the four copies of L12/chloroplast ribosome, qualitatively different from those attempted in eubacteria.", "output": {"entities": {"gene": [{"text": "L12 mRNA", "start": 57, "end": 65}, {"text": "rpl12 genes", "start": 120, "end": 131}, {"text": "L12/chloroplast ribosome", "start": 213, "end": 237}]}}, "schema": []}
{"input": "Genomic DNA clones containing the T-cell-specific human MAL gene were isolated.", "output": {"entities": {"gene": [{"text": "T-cell-specific human MAL gene", "start": 34, "end": 64}]}}, "schema": []}
{"input": "Expression of the dibasic proprotein processing enzyme furin is directed by multiple promoters.", "output": {"entities": {"gene": [{"text": "furin", "start": 55, "end": 60}]}}, "schema": []}
{"input": "Certain spt10 spontaneous alleles are good suppressors but have a normal growth rate, suggesting that the SPT10 protein may have two distinct functions.", "output": {"entities": {"gene": [{"text": "spt10", "start": 8, "end": 13}, {"text": "SPT10 protein", "start": 106, "end": 119}]}}, "schema": []}
{"input": "In Rat 1a cells, m1R stimulation of phospholipase C beta and the marked rise in intracellular calcium stimulated cyclic AMP (cAMP) synthesis, resulting in the activation of protein kinase A.", "output": {"entities": {"gene": [{"text": "m1R", "start": 17, "end": 20}, {"text": "phospholipase C beta", "start": 36, "end": 56}, {"text": "protein kinase A", "start": 173, "end": 189}]}}, "schema": []}
{"input": "The mutations did not affect the repression of CPA1 by arginine.", "output": {"entities": {"gene": [{"text": "CPA1", "start": 47, "end": 51}]}}, "schema": []}
{"input": "A segment of mRNA encoding the leader peptide of the CPA1 gene confers repression by arginine on a heterologous yeast gene transcript.", "output": {"entities": {"gene": [{"text": "CPA1 gene", "start": 53, "end": 62}]}}, "schema": []}
{"input": "Structure and expression of the alternative sigma factor, RpoN, in Rhodobacter capsulatus; physiological relevance of an autoactivated nifU2-rpoN superoperon.", "output": {"entities": {"gene": [{"text": "sigma factor", "start": 44, "end": 56}, {"text": "RpoN", "start": 58, "end": 62}, {"text": "nifU2", "start": 135, "end": 140}, {"text": "rpoN", "start": 141, "end": 145}]}}, "schema": []}
{"input": "Insertion of short oligonucleotides encoding the basic amino acid motifs 726-GRKRKSP-732 from IE175 and 500-VRPRKRR-506 from IE110 into deleted cytoplasmic forms of the two proteins restored the karyophilic phenotype and confirmed that these motifs are both necessary and sufficient for proper nuclear localization.", "output": {"entities": {"gene": [{"text": "IE175", "start": 94, "end": 99}, {"text": "IE110", "start": 125, "end": 130}]}}, "schema": []}
{"input": "Mapping of intracellular localization domains and evidence for colocalization interactions between the IE110 and IE175 nuclear transactivator proteins of herpes simplex virus.", "output": {"entities": {"gene": [{"text": "IE110", "start": 103, "end": 108}, {"text": "IE175", "start": 113, "end": 118}]}}, "schema": []}
{"input": "The revertant TATA boxes accelerated the kinetics of HIV replication when present in the context of an LTR containing a Sp1 mutation (deletion or site specific); no effect was observed on the infectivity of wild-type HIV.", "output": {"entities": {"gene": [{"text": "Sp1", "start": 120, "end": 123}]}}, "schema": []}
{"input": "Mitochondrial Mas70p signal anchor sequence.", "output": {"entities": {"gene": [{"text": "Mitochondrial Mas70p signal anchor sequence", "start": 0, "end": 43}]}}, "schema": []}
{"input": "Response to treatment was better in patients with less pretreatment (one-two prior treatments) than in heavily pretreated ones (more than three) and this relation was found to be statistically significant (p < 0. 05).", "output": {"entities": {}}, "schema": []}
{"input": "The class II Escherichia coli alanine tRNA synthetase aminoacylates RNA miniduplexes, which reconstruct the acceptor end of alanine tRNA with the critical G3: U70 base pair.", "output": {"entities": {"gene": [{"text": "class II Escherichia coli alanine tRNA synthetase aminoacylates RNA miniduplexes", "start": 4, "end": 84}, {"text": "alanine tRNA", "start": 124, "end": 136}]}}, "schema": []}
{"input": "A second study group, with intact cardiac innervation, consisted of 19 patients with stable angina pectoris class I to III.", "output": {"entities": {}}, "schema": []}
{"input": "Thus, we have separated the signal function from the anchor function of the 6. 7K SA domain.", "output": {"entities": {}}, "schema": []}
{"input": "Exposure to higher TPA concentrations decreased the content of these transcripts.", "output": {"entities": {}}, "schema": []}
{"input": "Our results indicate that the minimal requirements for induction of PEPCK by PKA and inhibition by insulin include: 1) the CREB activation domain, 2) the PEPCK TATA sequence, and 3) insulin-responsive hepatoma cells.", "output": {"entities": {"gene": [{"text": "PEPCK", "start": 68, "end": 73}, {"text": "PKA", "start": 77, "end": 80}, {"text": "insulin", "start": 99, "end": 106}, {"text": "CREB activation domain", "start": 123, "end": 145}, {"text": "PEPCK TATA sequence", "start": 154, "end": 173}, {"text": "insulin", "start": 182, "end": 189}]}}, "schema": []}
{"input": "Topical L-NNA attenuated the hypercapnic increase of CoBF by 52 +/-6% and CeBF by 29 +/-5% after 45-min exposure.", "output": {"entities": {}}, "schema": []}
{"input": "Restriction analysis and Southern hybridization revealed the presence of Tn5422 in all the plasmid-mediated cadmium-resistant L. monocytogenes strains tested but not in strains encoding cadmium resistance on the chromosome.", "output": {"entities": {"gene": [{"text": "Tn5422", "start": 73, "end": 79}]}}, "schema": []}
{"input": "The 7-day treatment resulted in a decrease in mitochondrial uptake of Rh123 and an increase in NAO uptake.", "output": {"entities": {}}, "schema": []}
{"input": "Thrombotic thrombocytopenic purpura in systemic lupus erythematosus.", "output": {"entities": {}}, "schema": []}
{"input": "Women' s opportunities for paid work outside the home are constrained by their role as primary carer within the family, writes Trudy Wynne.", "output": {"entities": {}}, "schema": []}
{"input": "Interestingly, the interaction of ZAP-70 with the motif was dependent on the presence of both ZAP-70 SH2 domains and both of the tyrosine residues in the motif, suggesting that ZAP-70 interacts with two phosphotyrosine residues and that the binding of the two SH2 domains is cooperative.", "output": {"entities": {"gene": [{"text": "ZAP-70", "start": 34, "end": 40}, {"text": "ZAP-70 SH2 domains", "start": 94, "end": 112}, {"text": "ZAP-70", "start": 177, "end": 183}, {"text": "SH2 domains", "start": 260, "end": 271}]}}, "schema": []}
{"input": "PRL-1 is able to dephosphorylate phosphotyrosine substrates, and mutation of the active-site cysteine residue abolishes this activity.", "output": {"entities": {"gene": [{"text": "PRL-1", "start": 0, "end": 5}]}}, "schema": []}
{"input": "50 kDa and 130-170 kDa were detected.", "output": {"entities": {}}, "schema": []}
{"input": "This strategy was used to place both the Tn903 neo gene and the Rhodosporidium toruloides phenylalanine ammonia lyase (PAL)-encoding gene under the transcriptional control of pPGK:: REP2.", "output": {"entities": {"gene": [{"text": "Tn903 neo gene", "start": 41, "end": 55}, {"text": "Rhodosporidium toruloides phenylalanine ammonia lyase", "start": 64, "end": 117}, {"text": "PAL", "start": 119, "end": 122}, {"text": "pPGK", "start": 175, "end": 179}, {"text": "REP2", "start": 182, "end": 186}]}}, "schema": []}
{"input": "In the case of congenital protein C deficiency, vitamin K antagonists must be started cautiously due to the risk of skin necrosis.", "output": {"entities": {"gene": [{"text": "protein C", "start": 26, "end": 35}]}}, "schema": []}
{"input": "In addition, we observe that the hUBF-promoter interaction is highly sensitive to the antagonistic effects of cisplatin-DNA adducts.", "output": {"entities": {"gene": [{"text": "hUBF-promoter", "start": 33, "end": 46}]}}, "schema": []}
{"input": "Simultaneous, bilateral and permanent ventilation with a diaphragm pacing in childhood: the implantation technique and indications", "output": {"entities": {}}, "schema": []}
{"input": "The pyrR and pyrP genes encoded polypeptides with calculated molecular masses of 19. 9 and 45. 2 kDa, respectively.", "output": {"entities": {"gene": [{"text": "pyrR", "start": 4, "end": 8}, {"text": "pyrP genes", "start": 13, "end": 23}]}}, "schema": []}
{"input": "To identify the precise location of the phosphorylation site on the 64-kDa protein, a step-by-step mutagenesis procedures was followed.", "output": {"entities": {}}, "schema": []}
{"input": "Co-transfection of a tat expressing plasmid with these viruses containing the tat ORF mutations resulted in higher levels of virus production demonstrating that the effects of both mutants are tat specific.", "output": {"entities": {"gene": [{"text": "tat", "start": 21, "end": 24}, {"text": "tat ORF", "start": 78, "end": 85}]}}, "schema": []}
{"input": "Analysis of the gag and rev proteins in the transfected cells demonstrated that these proteins were not detectable in cells transfected with the tat mutants but could be readily detected when the mutations were complemented in trans with a tat expression vector.", "output": {"entities": {"gene": [{"text": "gag", "start": 16, "end": 19}, {"text": "rev proteins", "start": 24, "end": 36}, {"text": "tat mutants", "start": 145, "end": 156}]}}, "schema": []}
{"input": "SIN-1 had no influence on either the ischemic parameters in the surface electrocardiogram (ECG) or the intracoronary ECG.", "output": {"entities": {}}, "schema": []}
{"input": "Stimulation of [3H] PA production upon CD3 cross-linking was 77% lower in permeabilized CD45-cells than in CD45 + cells, consistent with the reduced activity of p59fyn in CD45-cells.", "output": {"entities": {"gene": [{"text": "CD3", "start": 39, "end": 42}, {"text": "CD45-", "start": 88, "end": 93}, {"text": "CD45 +", "start": 107, "end": 113}, {"text": "p59fyn", "start": 161, "end": 167}, {"text": "CD45-", "start": 171, "end": 176}]}}, "schema": []}
{"input": "A Dictyostelium transformant overexpressing DdPTPa does not develop normally.", "output": {"entities": {"gene": [{"text": "DdPTPa", "start": 44, "end": 50}]}}, "schema": []}
{"input": "We postulate that CaM binding by HIV envelope proteins is likely to exert diverse modulatory effects, and the mechanism for HIV-induced cytotoxicity may involve, in part, inhibition of CaM-regulated cellular functions.", "output": {"entities": {"gene": [{"text": "CaM", "start": 18, "end": 21}, {"text": "HIV envelope proteins", "start": 33, "end": 54}, {"text": "CaM", "start": 185, "end": 188}]}}, "schema": []}
{"input": "There was no apparent effect of growth temperature on the steady-state levels of fad7 mRNA in wild type plants.", "output": {"entities": {"gene": [{"text": "fad7 mRNA", "start": 81, "end": 90}]}}, "schema": []}
{"input": "A second important molecule in TCR signal transduction is the guanine nucleotide binding protein, p21ras, which is coupled to the TCR by a protein tyrosine kinase dependent mechanism.", "output": {"entities": {"gene": [{"text": "TCR", "start": 31, "end": 34}, {"text": "guanine nucleotide binding protein", "start": 62, "end": 96}, {"text": "p21ras", "start": 98, "end": 104}, {"text": "TCR", "start": 130, "end": 133}, {"text": "protein tyrosine kinase", "start": 139, "end": 162}]}}, "schema": []}
{"input": "A series of 5'-deletions revealed that the fragment-218 to + 4 from the TSS had the highest promoter activity, nearly 1000-fold greater than the promoterless chloramphenicol acetyltransferase construct.", "output": {"entities": {"gene": [{"text": "chloramphenicol acetyltransferase construct", "start": 158, "end": 201}]}}, "schema": []}
{"input": "The lemdr1 gene was cloned in the expression vector pALTNEO and transfected into wild-type L. enriettii and the resulting transfected cells were resistant to vinblastine but at lower levels than in the selected mutant cells.", "output": {"entities": {"gene": [{"text": "lemdr1 gene", "start": 4, "end": 15}]}}, "schema": []}
{"input": "The bioavailability of etodolac from capsules exposed to stressed conditions was compared in both dogs and humans to capsules stored at RT conditions.", "output": {"entities": {}}, "schema": []}
{"input": "As regards lipid metabolism, the mean values for total triglycerides, cholesterol, LDL-cholesterol and HDL-cholesterol seen at the end of five years of Norplant-2 rod use and six months postremoval were similar to the preinsertion mean.", "output": {"entities": {"gene": [{"text": "LDL-cholesterol", "start": 83, "end": 98}, {"text": "HDL-cholesterol", "start": 103, "end": 118}]}}, "schema": []}
{"input": "To our knowledge this is the first case in which a probable association between cholelithiasis and Wildervanck' s syndrome has been recorded.", "output": {"entities": {}}, "schema": []}
{"input": "Addition of phalloidin-stabilized F-actin nuclei and phalloidin restored L266D actin' s ability to polymerize at 4 degrees C.", "output": {"entities": {"gene": [{"text": "F-actin", "start": 34, "end": 41}, {"text": "actin", "start": 79, "end": 84}]}}, "schema": []}
{"input": "Northern (RNA) analysis demonstrated expression of human PI 3-kinase in all tissues and cell lines tested.", "output": {"entities": {"gene": [{"text": "PI 3-kinase", "start": 57, "end": 68}]}}, "schema": []}
{"input": "These results demonstrate the existence of different PI 3-kinase isoforms and define a family of genes encoding distinct PI 3-kinase catalytic subunits that can associate with p85.", "output": {"entities": {"gene": [{"text": "PI 3-kinase isoforms", "start": 53, "end": 73}, {"text": "PI 3-kinase catalytic subunits", "start": 121, "end": 151}, {"text": "p85", "start": 176, "end": 179}]}}, "schema": []}
{"input": "One complex most likely contained Sp1, and another complex showed S-phase-specific binding, suggesting a direct role in the cell-cycle-dependent R1 gene expression.", "output": {"entities": {"gene": [{"text": "Sp1", "start": 34, "end": 37}, {"text": "R1 gene", "start": 145, "end": 152}]}}, "schema": []}
{"input": "The rate of enzymic stimulation induced by a given nitrate correlates closely with the rate of measured NO production from the nitrate molecule.", "output": {"entities": {}}, "schema": []}
{"input": "Two patients were treated successfully with a combination of metronidazole (a tissue amoebicide) and diloxanide (a lumenal amoebicide).", "output": {"entities": {}}, "schema": []}
{"input": "We have identified in the 5' untranslated region of the Drosophila copia retrotransposon, 3' to the left LTR, a sequence for transcriptional regulation by homeoproteins.", "output": {"entities": {"gene": [{"text": "Drosophila copia retrotransposon", "start": 56, "end": 88}]}}, "schema": []}
{"input": "By using the full-length cytoplasmic domain and mutants with progressive carboxy-terminal deletions, internal deletions, or point mutations, we identified the first 150 amino acid residues of LIFR as the minimal region necessary for signaling.", "output": {"entities": {"gene": [{"text": "LIFR", "start": 192, "end": 196}]}}, "schema": []}
{"input": "Oligonucleotide competitors were used to evaluate the accessibility of the TATA-binding site in TIF-IB, TFIID, and TFIIIB.", "output": {"entities": {"gene": [{"text": "TIF-IB", "start": 96, "end": 102}, {"text": "TFIID", "start": 104, "end": 109}, {"text": "TFIIIB", "start": 115, "end": 121}]}}, "schema": []}
{"input": "The 227-to-239 region blocked ADR1 activity independently of the TAD present on ADR1, ADR1 DNA binding, and specific ADH2 promoter sequences.", "output": {"entities": {"gene": [{"text": "ADR1", "start": 30, "end": 34}, {"text": "TAD", "start": 65, "end": 68}, {"text": "ADR1", "start": 80, "end": 84}, {"text": "ADR1", "start": 86, "end": 90}, {"text": "ADH2 promoter sequences", "start": 117, "end": 140}]}}, "schema": []}
{"input": "TGF beta 1 expression is largely governed by three AP-1 binding sites located in two different promoters of this gene.", "output": {"entities": {"gene": [{"text": "TGF beta 1", "start": 0, "end": 10}, {"text": "AP-1 binding sites", "start": 51, "end": 69}]}}, "schema": []}
{"input": "Repeated administration of GRg2 20 mg/kg i. p. significantly improved the CYP-induced recognitional deficits by increasing the CYP-decreased rate from 55. 8 +/-9. 6 to 80. 8 +/-4. 2 in d 3 learning acquisition (F (1, 14) = 5. 6, p < 0. 05), from 53. 4 +/-8. 4 to 60. 0 +/-8. 2 in 48 h memory acquisition (F (1, 14) = 7. 5, p < 0. 05) and from 55. 0 +/-5. 5 to 88. 3 +/-2. 5 in 24 h memory retention (F (1, 12) 27. 5, p < 0. 01) as well as from 60. 0 +/-6. 8 to 85. 6 +/-6. 9 in 48 h memory retrieval (F (1, 12) = 5. 2, p < 0. 05), respectively.", "output": {"entities": {}}, "schema": []}
{"input": "The therapeutic action of cyclosporin A (Sandimmun): its application in rheumatoid arthritis.", "output": {"entities": {}}, "schema": []}
{"input": "Pentazocine analgesia: is there a niche for Talwin Nx? Pentazocine can be a useful analgesic agent for the management of acute dental pain.", "output": {"entities": {}}, "schema": []}
{"input": "In addition, REP21 plants were resistant to an unusually broad range of tobamoviruses including tomato mosaic virus, tobacco mild green mosaic virus, TMV-U5, green tomato atypical mosaic virus, and ribgrass mosaic virus.", "output": {"entities": {}}, "schema": []}
{"input": "In our studies, we utilized HIV-1 HXB2 and HIV-1 Z2Z6 core enhancers because the Z2Z6 strain has a single point mutation flanking the right ETS-binding site.", "output": {"entities": {"gene": [{"text": "HXB2", "start": 34, "end": 38}, {"text": "Z2Z6 core enhancers", "start": 49, "end": 68}, {"text": "Z2Z6", "start": 81, "end": 85}, {"text": "ETS-binding site", "start": 140, "end": 156}]}}, "schema": []}
{"input": "Because of the small number of visceral angiography procedures performed (38), no definitive conclusions could be drawn as to the differences between ionic and nonionic agents regarding grade-2 and grade-3 adverse events.", "output": {"entities": {}}, "schema": []}
{"input": "The Stryker frame modification to the standard Dornier HM3 lithotriptor allows for improved visualization and easier localization of distal ureteral calculi compared to the standard gantry.", "output": {"entities": {}}, "schema": []}
{"input": "Glomerular mesangial cells expressed an abundant 1. 1 kb mRNA transcript for Id1, but in contrast to other cell types Id1 mRNA was expressed in both randomly cycling cells and in serum-deprived, quiescent cultures.", "output": {"entities": {"gene": [{"text": "Id1", "start": 77, "end": 80}, {"text": "Id1 mRNA", "start": 118, "end": 126}]}}, "schema": []}
{"input": "A single 1. 8-kb transcript mRNA was detected by Northern (RNA) blot analysis, and its 5' end maps to a position 51 bp upstream from the site of initiation of protein synthesis.", "output": {"entities": {}}, "schema": []}
{"input": "The sequence similarity has suggested that SCG10 and stathmin have been derived from structurally and evolutionarily related genes.", "output": {"entities": {"gene": [{"text": "SCG10", "start": 43, "end": 48}, {"text": "stathmin", "start": 53, "end": 61}]}}, "schema": []}
{"input": "These data are consistent with the idea that the neuron-specific SCG10 gene evolved by duplication and modification of the more broadly expressed stathmin/Lap18 gene.", "output": {"entities": {"gene": [{"text": "neuron-specific SCG10 gene", "start": 49, "end": 75}, {"text": "stathmin", "start": 146, "end": 154}, {"text": "Lap18", "start": 155, "end": 160}]}}, "schema": []}
{"input": "We found that T3 (10 (-8) M) selectively stimulates transcription from rGH-TRE-and TREpal-, but not ME-TRE-and F2-TRE-, containing templates in which these TREs are linked in front of the rGH minimal promoter containing only the TATA box binding protein, but not any other proximal binding protein, sequence.", "output": {"entities": {"gene": [{"text": "rGH", "start": 71, "end": 74}, {"text": "rGH minimal promoter", "start": 188, "end": 208}, {"text": "TATA box binding protein", "start": 229, "end": 253}]}}, "schema": []}
{"input": "However, artificially ventilated rats, pretreated with MK-801, were more sensitive (lethal cocaine dose, 76. 6 +/-8. 0 mg/kg, n = 5) than vehicle pretreated rats (129. 4 +/-15. 8 mg/kg, n = 6), indicating that MK-801 may increase both the respiratory and the cardiac toxicity of cocaine in urethane anesthetized rats.", "output": {"entities": {}}, "schema": []}
{"input": "ENV also was secreted from P. pastoris using the S. cerevisiae alpha-factor prepro secretion leader and the S. cerevisiae invertase signal sequence.", "output": {"entities": {"gene": [{"text": "ENV", "start": 0, "end": 3}, {"text": "S. cerevisiae alpha-factor prepro secretion leader", "start": 49, "end": 99}, {"text": "S. cerevisiae invertase signal sequence", "start": 108, "end": 147}]}}, "schema": []}
{"input": "The following evidence indicates that the 69-kD protein is a common, rather than a U1-specific, protein, possibly associating with the snRNP core particles by protein-protein interaction.", "output": {"entities": {"gene": [{"text": "U1", "start": 83, "end": 85}]}}, "schema": []}
{"input": "Praziquantel and Albendazole were found effective in the treatment of neurocysticercosis, but because of serious side effects encountered in some cases, the drugs should be used cautiously in selected cases only.", "output": {"entities": {}}, "schema": []}
{"input": "Transcriptional analysis of a series of deletion mutants of the gene in the nuclear extracts prepared from the middle silk gland of 2-day-old fifth instar larvae revealed the presence of multiple cis-regulatory elements located both upstream and downstream of the initiation site.", "output": {"entities": {}}, "schema": []}
{"input": "One of these elements, the homeodomain-binding element, was identified to mediate negative regulation.", "output": {"entities": {"gene": [{"text": "homeodomain-binding element", "start": 27, "end": 54}]}}, "schema": []}
{"input": "Monospecific antibodies raised against rat cytochrome P-450 1A1 recognized a protein in the hepatic microsomes of the double-crested cormorant, and also in those of the great blue heron (Ardea herodias), using immunoblotting.", "output": {"entities": {"gene": [{"text": "rat cytochrome P-450 1A1", "start": 39, "end": 63}]}}, "schema": []}
{"input": "Mutations in the nuclear gene CBP1 of Saccharomyces cerevisiae result in degradation of mitochondrially encoded cytochrome b (cob) RNA; thus, the cells are unable to respire.", "output": {"entities": {"gene": [{"text": "nuclear gene CBP1 of Saccharomyces cerevisiae", "start": 17, "end": 62}, {"text": "mitochondrially encoded cytochrome b", "start": 88, "end": 124}, {"text": "cob", "start": 126, "end": 129}]}}, "schema": []}
{"input": "The 5' ends of F3R late transcripts were located to an A within the sequence 5'-TAAAG, 41 nt downstream from the early promoter and 17 nt upstream from the initiation codon.", "output": {"entities": {"gene": [{"text": "F3R", "start": 15, "end": 18}]}}, "schema": []}
{"input": "NF-kappa B p65, p50, and Rel functionally synergize with C/EBP alpha, C/EBP beta, and C/EBP delta.", "output": {"entities": {"gene": [{"text": "NF-kappa B p65", "start": 0, "end": 14}, {"text": "p50", "start": 16, "end": 19}, {"text": "Rel", "start": 25, "end": 28}, {"text": "C/EBP alpha", "start": 57, "end": 68}, {"text": "C/EBP beta", "start": 70, "end": 80}, {"text": "C/EBP delta", "start": 86, "end": 97}]}}, "schema": []}
{"input": "It could be detected exclusively in the culture medium of cDNA-transfected COS cells.", "output": {"entities": {}}, "schema": []}
{"input": "The first group of sequential BMB showed a significant progress to myelofibrosis in so-called \" Chronic Megakaryocytic-Granulocytic Myelosis \"--CMGM-, which corresponds to Agnogenic Myeloid Metaplasia-AMM-in 72. 4% (21/29 patients), as well as in CML with megakaryocytic increase-CML. MI-in 39. 2% (20/51).", "output": {"entities": {}}, "schema": []}
{"input": "These lesions were asymptomatic, but both were characterized clinically by central ulceration.", "output": {"entities": {}}, "schema": []}
{"input": "Release of this selective pressure, however, gave way to homologous resolution of the cointegrate structures.", "output": {"entities": {}}, "schema": []}
{"input": "The equivalent of the third ligand, H-87, is T-47 in the PSTAIRE sequence motif.", "output": {"entities": {}}, "schema": []}
{"input": "Botulinum toxin: preferred treatment for hemifacial spasm.", "output": {"entities": {"gene": [{"text": "Botulinum toxin", "start": 0, "end": 15}]}}, "schema": []}
{"input": "2-AP induced marked, steady rises in mRNA accumulation from both transfected and chromosomally integrated HIV-1 constructs but no increases from an endogenous gene encoding gamma-actin or glucose 6-phosphate dehydrogenase.", "output": {"entities": {"gene": [{"text": "gamma-actin", "start": 173, "end": 184}, {"text": "glucose 6-phosphate dehydrogenase", "start": 188, "end": 221}]}}, "schema": []}
{"input": "On the other hand, the structures of the b-Zip domain are well conserved among these Maf-related proteins.", "output": {"entities": {"gene": [{"text": "Maf-related proteins", "start": 85, "end": 105}]}}, "schema": []}
{"input": "The Functional Independence Measure: a comparative study of clinician and self ratings.", "output": {"entities": {}}, "schema": []}
{"input": "Polymyxin B was given intravenously for 1 week postburn in doses designed to neutralize circulating endotoxemia.", "output": {"entities": {}}, "schema": []}
{"input": "SvO2 can be determined in vitro and in vivo.", "output": {"entities": {}}, "schema": []}
{"input": "The transverse relaxation time (T2) and apparent diffusion coefficient of water were determined.", "output": {"entities": {}}, "schema": []}
{"input": "These findings suggest a functional cross-talk between RB protein and p21ras, which balances the cell phenotype between normal and transformed states.", "output": {"entities": {"gene": [{"text": "RB protein", "start": 55, "end": 65}, {"text": "p21ras", "start": 70, "end": 76}]}}, "schema": []}
{"input": "The other transmembrane regions as well as the nucleoplasmic domain are not required for sorting.", "output": {"entities": {}}, "schema": []}
{"input": "These cell lines, selected for the ability to support the replication of a temperature-sensitive VP5 mutant, were used to isolate VP5 and VP23 null mutants.", "output": {"entities": {"gene": [{"text": "VP5 mutant", "start": 97, "end": 107}, {"text": "VP5", "start": 130, "end": 133}, {"text": "VP23", "start": 138, "end": 142}]}}, "schema": []}
{"input": "The E1 nuclear transport motif is highly conserved in the animal and human papillomaviruses and is encoded in a similar region in the related E1 genes.", "output": {"entities": {"gene": [{"text": "E1 nuclear transport motif", "start": 4, "end": 30}, {"text": "E1 genes", "start": 142, "end": 150}]}}, "schema": []}
{"input": "The E1 replication protein of bovine papillomavirus type 1 contains an extended nuclear localization signal that includes a p34cdc2 phosphorylation site.", "output": {"entities": {"gene": [{"text": "E1 replication protein", "start": 4, "end": 26}, {"text": "p34cdc2", "start": 124, "end": 131}]}}, "schema": []}
{"input": "In the present study, beta-funaltrexamine (beta-FNA) and naltrindole (NTI) (nonequilibrium mu-and delta-antagonist, respectively) were used to precipitate withdrawal in butorphanol-dependent rats.", "output": {"entities": {}}, "schema": []}
{"input": "Mutations at the extreme C-terminus of EIAV Tat impaired both RNA binding and activation domain functions, suggesting effects on secondary or tertiary structure.", "output": {"entities": {"gene": [{"text": "EIAV Tat", "start": 39, "end": 47}]}}, "schema": []}
{"input": "This observation suggests that the methyl-directed repair system utilizes the proximal d (GATC) sequence to direct correction.", "output": {"entities": {}}, "schema": []}
{"input": "Lithium phthalocyanine (LiPc) is a prototype of another generation of synthetic, metallic-organic, paramagnetic crystallites that appear very useful for in vitro and in vivo electron paramagnetic resonance oximetry.", "output": {"entities": {}}, "schema": []}
{"input": "IE2-IE2 interactions were mapped to a domain containing a putative helix-turn-helix motif located near the C terminus of IE2, between amino acids 456 and 539.", "output": {"entities": {"gene": [{"text": "IE2", "start": 0, "end": 3}, {"text": "IE2", "start": 4, "end": 7}, {"text": "IE2", "start": 121, "end": 124}]}}, "schema": []}
{"input": "Precipitation using GST fusion proteins containing Fyn SH2, SH3, and SH2/SH3 domains revealed that PI 3-kinase bound principally to the SH3 domain of Fyn.", "output": {"entities": {"gene": [{"text": "GST fusion proteins", "start": 20, "end": 39}, {"text": "Fyn SH2", "start": 51, "end": 58}, {"text": "SH3", "start": 60, "end": 63}, {"text": "SH2", "start": 69, "end": 72}, {"text": "SH3", "start": 73, "end": 76}, {"text": "PI 3-kinase", "start": 99, "end": 110}, {"text": "SH3 domain", "start": 136, "end": 146}, {"text": "Fyn", "start": 150, "end": 153}]}}, "schema": []}
{"input": "A sheep testicular cDNA library constructed in pcDNA1 vector was screened with a probe generated by polymerase chain reaction (PCR) and corresponding to a 1. 6 kb fragment of the rat luteinizing hormone receptor cDNA.", "output": {"entities": {"gene": [{"text": "rat luteinizing hormone receptor cDNA", "start": 179, "end": 216}]}}, "schema": []}
{"input": "Two putative Rev proteins with apparent molecular masses of 18 and 16 kDa were expressed by p2/2 and p176, while p20 expressed only a 16-kDa species.", "output": {"entities": {"gene": [{"text": "Rev proteins", "start": 13, "end": 25}, {"text": "p2/2", "start": 92, "end": 96}, {"text": "p176", "start": 101, "end": 105}, {"text": "p20", "start": 113, "end": 116}]}}, "schema": []}
{"input": "Defects of fibrillin (FBN1), a glycoprotein component of the extracellular microfibril, cause Marfan syndrome.", "output": {"entities": {"gene": [{"text": "fibrillin", "start": 11, "end": 20}, {"text": "FBN1", "start": 22, "end": 26}]}}, "schema": []}
{"input": "A region approximately 100 bp upstream from the transcription start point of virB was identified as being necessary for full activation of this promoter by VirF.", "output": {"entities": {"gene": [{"text": "virB", "start": 77, "end": 81}, {"text": "VirF", "start": 156, "end": 160}]}}, "schema": []}
{"input": "METHODS: Fifty-one healthy eyes, 169 ocular hypertensive eyes with normal visual fields, and 132 glaucomatous eyes with early visual field defects were evaluated with qualitative and quantitative measures of structural damage to the optic nerve and nerve fiber layer.", "output": {"entities": {}}, "schema": []}
{"input": "Consistent with the hypothesis that it acts as transcriptional regulator, wild-type p53 protein binds DNA and activates transcription of several promoters.", "output": {"entities": {"gene": [{"text": "wild-type p53 protein", "start": 74, "end": 95}]}}, "schema": []}
{"input": "Instead, mRNA of 2. 0 and 2. 8 kb are detected in varying abundance.", "output": {"entities": {}}, "schema": []}
{"input": "The sequence of the HIR1 gene predicts an 88-kDa protein with three repeats of a motif found in the G beta subunit of retinal transducin and in a yeast transcriptional repressor, Tup1.", "output": {"entities": {"gene": [{"text": "HIR1 gene", "start": 20, "end": 29}, {"text": "G beta subunit", "start": 100, "end": 114}, {"text": "retinal transducin", "start": 118, "end": 136}, {"text": "Tup1", "start": 179, "end": 183}]}}, "schema": []}
{"input": "All of these data suggest that replication of UV-damaged templates occurs in vitro as it does in vivo and that this replication results in mutation fixation.", "output": {"entities": {}}, "schema": []}
{"input": "Biol.", "output": {"entities": {}}, "schema": []}
{"input": "265, 1102-1110).", "output": {"entities": {}}, "schema": []}
{"input": "The use of this model for investigating pathophysiologically significant issues in denervating diseases is illustrated with five different sets of parameters.", "output": {"entities": {}}, "schema": []}
{"input": "We describe a novel cytoplasmic tyrosine kinase, termed BPK (B cell progenitor kinase), which is expressed in all stages of the B lineage and in myeloid cells.", "output": {"entities": {"gene": [{"text": "cytoplasmic tyrosine kinase", "start": 20, "end": 47}, {"text": "BPK", "start": 56, "end": 59}, {"text": "B cell progenitor kinase", "start": 61, "end": 85}]}}, "schema": []}
{"input": "However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.", "output": {"entities": {"gene": [{"text": "L-plastin", "start": 9, "end": 18}]}}, "schema": []}
{"input": "Finally, we present evidence that fimbrin is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine.", "output": {"entities": {"gene": [{"text": "fimbrin", "start": 34, "end": 41}, {"text": "plastin isoform", "start": 62, "end": 77}]}}, "schema": []}
{"input": "The DNase I footprint extended 5' in the silencer region to include an inverted repeat of a six-nucleotide motif (epsilon-267 to-278 bp) which shares 5 of 6 bases with the GATA-1 consensus sequence.", "output": {"entities": {"gene": [{"text": "DNase I", "start": 4, "end": 11}, {"text": "GATA-1 consensus sequence", "start": 172, "end": 197}]}}, "schema": []}
{"input": "Furthermore, competitor containing the YY1 consensus sequence competed for protein B binding, whereas competitor containing a perfect yeast ABF-1 consensus sequence did not. (ABSTRACT TRUNCATED AT 400 WORDS)", "output": {"entities": {"gene": [{"text": "YY1 consensus sequence", "start": 39, "end": 61}, {"text": "protein B", "start": 75, "end": 84}, {"text": "yeast ABF-1 consensus sequence", "start": 134, "end": 164}]}}, "schema": []}
{"input": "Naval personnel who exceed standards for% BF can be separated from active duty.", "output": {"entities": {}}, "schema": []}
{"input": "Weak promoter activity was observed for the promoter of the C1 and C2 ORFs (C1-C2 gene) and for the promoter of the V1 ORF.", "output": {"entities": {"gene": [{"text": "C1", "start": 60, "end": 62}, {"text": "C2", "start": 67, "end": 69}, {"text": "C1", "start": 76, "end": 78}, {"text": "C2", "start": 79, "end": 81}, {"text": "V1 ORF", "start": 116, "end": 122}]}}, "schema": []}
{"input": "The activity of the coat protein promoter of chloris striate mosaic virus is enhanced by its own and C1-C2 gene products.", "output": {"entities": {"gene": [{"text": "coat protein promoter", "start": 20, "end": 41}, {"text": "C1", "start": 101, "end": 103}, {"text": "C2", "start": 104, "end": 106}]}}, "schema": []}
{"input": "The amino acid sequence alignment of TC II with that of other Cbl binding proteins (rat intrinsic factor, human transcobalamin I and porcine haptocorrin) revealed only 33% overall homology.", "output": {"entities": {"gene": [{"text": "TC II", "start": 37, "end": 42}, {"text": "Cbl binding proteins", "start": 62, "end": 82}, {"text": "rat intrinsic factor", "start": 84, "end": 104}, {"text": "human transcobalamin I", "start": 106, "end": 128}, {"text": "porcine haptocorrin", "start": 133, "end": 152}]}}, "schema": []}
{"input": "This short communication compares a novel fluorimetric microplate enzyme immunoassay (FEIA) with a commercial time-resolved fluoroimmunoassay for the determination of thyrotropin in dried blood spots.", "output": {"entities": {"gene": [{"text": "thyrotropin", "start": 167, "end": 178}]}}, "schema": []}
{"input": "The evaluation was performed using a retrospective study design with newborn blood samples from three screening centres.", "output": {"entities": {}}, "schema": []}
{"input": "When ligated to the proIL-1 beta cap site-proximal region (located between-131 to + 12), both the proIL-1 beta and the simian virus 40 enhancer elements functioned more efficiently in monocytes than in HeLa cells, which are not normally competent for IL-1 beta expression.", "output": {"entities": {"gene": [{"text": "proIL-1 beta cap site-proximal region", "start": 20, "end": 57}, {"text": "proIL-1 beta", "start": 98, "end": 110}, {"text": "simian virus 40 enhancer elements", "start": 119, "end": 152}, {"text": "IL-1 beta", "start": 251, "end": 260}]}}, "schema": []}
{"input": "Therefore, PC-PLC is a component of a signal transduction pathway leading to transcription of c-fos and junB that collaborates with c-myc and is independent of PKC-delta and Ras activation.", "output": {"entities": {"gene": [{"text": "PC-PLC", "start": 11, "end": 17}, {"text": "c-fos", "start": 94, "end": 99}, {"text": "junB", "start": 104, "end": 108}, {"text": "c-myc", "start": 132, "end": 137}, {"text": "PKC-delta", "start": 160, "end": 169}, {"text": "Ras", "start": 174, "end": 177}]}}, "schema": []}
{"input": "Southern blot analysis using probes from the 3' portions of the genomic and B. napus MA and MB cDNA clones showed that MA type myrosinases are encoded by approximately 4 genes, while MB type myrosinases are encoded by more than 10 genes in B. napus.", "output": {"entities": {"gene": [{"text": "B. napus MA", "start": 76, "end": 87}, {"text": "MB cDNA", "start": 92, "end": 99}, {"text": "MA type myrosinases", "start": 119, "end": 138}, {"text": "MB type myrosinases", "start": 183, "end": 202}]}}, "schema": []}
{"input": "Type II could be divided further into two forms (IIA and IIB) that may represent two underscribed species or developmental stages of the same species.", "output": {"entities": {}}, "schema": []}
{"input": "In the present study we demonstrated a unique mechanism of action of 8-Cl-cAMP in the regulation of these kinase isozymes in HL-60 human promyelocytic leukemia cells.", "output": {"entities": {}}, "schema": []}
{"input": "There are, however, several differences between the two new ars sequences.", "output": {"entities": {}}, "schema": []}
{"input": "Pokeweed mitogen (PWM) or anti-CD3 significantly increases c-jun messenger RNA (mRNA) levels in T cells.", "output": {"entities": {"gene": [{"text": "Pokeweed mitogen", "start": 0, "end": 16}, {"text": "PWM", "start": 18, "end": 21}, {"text": "anti-CD3", "start": 26, "end": 34}, {"text": "c-jun messenger RNA (mRNA)", "start": 59, "end": 85}]}}, "schema": []}
{"input": "Following seizure induction, MABP increased to 105 mm Hg and brain pHi fell to 6. 79 +/-0. 03 within 15 min and remained at this level for 1 h (P < 0. 001).", "output": {"entities": {}}, "schema": []}
{"input": "Sterile mutants of Saccharomyces cerevisiae were isolated from alpha * cells having the a/alpha aar1-6 genotype (exhibiting alpha mating ability and weak a mating ability as a result of a defect in a1-alpha 2 repression).", "output": {"entities": {"gene": [{"text": "a/alpha aar1-6", "start": 88, "end": 102}, {"text": "a1-alpha 2", "start": 198, "end": 208}]}}, "schema": []}
{"input": "OBJECTIVE: Our purpose was to determine the simultaneous concentrations of serum cotinine in both fetal and maternal blood.", "output": {"entities": {}}, "schema": []}
{"input": "5 micrograms/l was detected in urine from some non-occupationally exposed persons.", "output": {"entities": {}}, "schema": []}
{"input": "Finger associated box-zinc finger proteins (FAX-ZFPs) constitute a subfamily of the many C2H2 type ZFPs in Xenopus laevis.", "output": {"entities": {"gene": [{"text": "Finger associated box-zinc finger proteins", "start": 0, "end": 42}, {"text": "FAX-ZFPs", "start": 44, "end": 52}, {"text": "C2H2 type ZFPs", "start": 89, "end": 103}]}}, "schema": []}
{"input": "Further evidence for a clustered organization of FAX-ZFP transcription units is provided by Southern blot analysis of large genomic restriction fragments separated by transverse field gel electrophoresis, and by in situ hybridization on intact chromosomes.", "output": {"entities": {"gene": [{"text": "FAX", "start": 49, "end": 52}, {"text": "ZFP", "start": 53, "end": 56}]}}, "schema": []}
{"input": "Mutational analyses have demonstrated the importance of sequences within the 327 bp segment that contain a putative cyclic AMP responsive element binding protein (CREB) binding site for TGF-beta 1 and PMA responsiveness and putative PU-1 and Sp1 binding sites for basal promoter activity.", "output": {"entities": {"gene": [{"text": "cyclic AMP responsive element binding protein", "start": 116, "end": 161}, {"text": "CREB", "start": 163, "end": 167}, {"text": "TGF-beta 1", "start": 186, "end": 196}, {"text": "PU-1", "start": 233, "end": 237}, {"text": "Sp1 binding sites", "start": 242, "end": 259}]}}, "schema": []}
{"input": "(1992) J.", "output": {"entities": {}}, "schema": []}
{"input": "We obtained the prevalence of IgG antibodies against Trypanosoma cruzi among 1076 blood donors at the Instituto Nacional de Cardiologia \" Ignacio Chavez \" in Mexico City.", "output": {"entities": {"gene": [{"text": "IgG antibodies", "start": 30, "end": 44}]}}, "schema": []}
{"input": "Examination of the immediate sequence 5' to the mRNA start site reveals no TATA box and multiple known enhancer sequences.", "output": {"entities": {}}, "schema": []}
{"input": "Pseudosubstrate (19-36), derived from the C-terminus of Ca-dependent PKC isotypes, inhibited beta-PKC but not nPKC activity using either Histone IIIS or peptide (19-31) as substrate.", "output": {"entities": {"gene": [{"text": "Ca-dependent PKC isotypes", "start": 56, "end": 81}, {"text": "beta-PKC", "start": 93, "end": 101}, {"text": "nPKC", "start": 110, "end": 114}, {"text": "Histone IIIS", "start": 137, "end": 149}]}}, "schema": []}
{"input": "This may account, at least in part, for the ability of excess wt p53 to inhibit cell proliferation and to interfere with neoplastic processes.", "output": {"entities": {"gene": [{"text": "wt p53", "start": 62, "end": 68}]}}, "schema": []}
{"input": "Northern blot analysis of total cellular RNA indicated that xylP encodes a 1. 3-kb transcript which is induced by xylan.", "output": {"entities": {"gene": [{"text": "xylP", "start": 60, "end": 64}]}}, "schema": []}
{"input": "These data show that PTH and cAMP can repress collagen promoter activity in calvariae from transgenic mice, suggesting that the alpha 1 (I) collagen promoter may contain cis elements down-stream of-2. 3 kilobases that mediate PTH and cAMP repression of collagen gene expression in bone.", "output": {"entities": {"gene": [{"text": "PTH", "start": 21, "end": 24}, {"text": "collagen promoter", "start": 46, "end": 63}, {"text": "alpha 1 (I) collagen promoter", "start": 128, "end": 157}, {"text": "PTH", "start": 226, "end": 229}, {"text": "collagen gene", "start": 253, "end": 266}]}}, "schema": []}
{"input": "The yeast gene that encodes eIF-5, designated TIF5, has been isolated and expressed in Escherichia coli to yield a catalytically active eIF-5 protein.", "output": {"entities": {"gene": [{"text": "eIF-5", "start": 28, "end": 33}, {"text": "TIF5", "start": 46, "end": 50}, {"text": "eIF-5 protein", "start": 136, "end": 149}]}}, "schema": []}
{"input": "Xylose-and arabinose-containing polymers were better digested than was cellulose for both breads.", "output": {"entities": {}}, "schema": []}
{"input": "The alpha-subunit by itself binds to telomeric DNA.", "output": {"entities": {}}, "schema": []}
{"input": "We conclude that the alpha-subunit of the telomere-binding protein, like many transcription factors, has separable DNA-binding and protein-protein interaction domains.", "output": {"entities": {"gene": [{"text": "telomere-binding protein", "start": 42, "end": 66}]}}, "schema": []}
{"input": "Calcification of a cariogenic Streptococcus and of Corynebacterium (Bacterionema) matruchotii.", "output": {"entities": {}}, "schema": []}
{"input": "A comparison of the promoters for muMIP-1 beta and muMIP-1 alpha reveals a conserved CK-1 element, but transient expression studies in RAW 264. 7 macrophages with proximal fragments of either the muMIP-1 beta or the muMIP-1 alpha 5' promoter fused to a human growth hormone reporter gene link LPS-inducibility in both to promoter segments near to, but not identical with, the consensus CK-1 sequence.", "output": {"entities": {"gene": [{"text": "muMIP-1 beta", "start": 34, "end": 46}, {"text": "muMIP-1 alpha", "start": 51, "end": 64}, {"text": "muMIP-1 beta", "start": 196, "end": 208}, {"text": "muMIP-1 alpha 5' promoter", "start": 216, "end": 241}, {"text": "human growth hormone reporter gene", "start": 253, "end": 287}]}}, "schema": []}
{"input": "Sequence analysis and identification of two hyp regulatory mutants.", "output": {"entities": {"gene": [{"text": "hyp regulatory mutants", "start": 44, "end": 66}]}}, "schema": []}
{"input": "The gene encoding the receptor for macrophage colony-stimulating factor 1 (CSF-1), the c-fms protooncogene, is selectively expressed in immature and mature mononuclear phagocytes and trophoblasts.", "output": {"entities": {"gene": [{"text": "macrophage colony-stimulating factor 1", "start": 35, "end": 73}, {"text": "CSF-1", "start": 75, "end": 80}, {"text": "c-fms protooncogene", "start": 87, "end": 106}]}}, "schema": []}
{"input": "Since the regulation of SWI4 is required for normal cell cycle progression, we have characterized cis-and trans-acting regulators of SWI4 transcription.", "output": {"entities": {"gene": [{"text": "SWI4", "start": 24, "end": 28}, {"text": "SWI4", "start": 133, "end": 137}]}}, "schema": []}
{"input": "It also suggests that there is another pathway which can activate SWI4 transcription in the absence of SWI6.", "output": {"entities": {"gene": [{"text": "SWI4", "start": 66, "end": 70}, {"text": "SWI6", "start": 103, "end": 107}]}}, "schema": []}
{"input": "Multiple SWI6-dependent cis-acting elements control SWI4 transcription through the cell cycle.", "output": {"entities": {"gene": [{"text": "SWI6", "start": 9, "end": 13}, {"text": "SWI4", "start": 52, "end": 56}]}}, "schema": []}
{"input": "Biol.", "output": {"entities": {}}, "schema": []}
{"input": "Patient characteristics associated with deep wounds as well as patient and wound characteristics predictive of the extent of healing and time required for healing were identified.", "output": {"entities": {}}, "schema": []}
{"input": "Yeast mutants lacking a functional NOP1 gene can be complemented by human fibrillarin but are temperature sensitive for growth and impaired in pre-rRNA processing.", "output": {"entities": {"gene": [{"text": "NOP1 gene", "start": 35, "end": 44}, {"text": "human fibrillarin", "start": 68, "end": 85}]}}, "schema": []}
{"input": "The patients were divided into ischaemia and non-ischaemia groups on the basis of the change in lactate extraction ratio during balloon inflation.", "output": {"entities": {}}, "schema": []}
{"input": "Both immunophilins may have important roles in receptor assembly and may represent a new category of ligand-and calcium-dependent modulators of protein function.", "output": {"entities": {"gene": [{"text": "immunophilins", "start": 5, "end": 18}]}}, "schema": []}
{"input": "Umweltchem.", "output": {"entities": {}}, "schema": []}
{"input": "Contrary to expectations, we find a relatively high level of variation in the stripe 2 enhancer region, including point substitutions and insertion/deletions in binding sites, and a comparable level of variation in the other noncoding regions.", "output": {"entities": {"gene": [{"text": "stripe 2", "start": 78, "end": 86}]}}, "schema": []}
{"input": "I report here that induction of HSP82 is regulated by the early meiotic IME1-IME2 transcriptional cascade.", "output": {"entities": {"gene": [{"text": "HSP82", "start": 32, "end": 37}, {"text": "IME1", "start": 72, "end": 76}, {"text": "IME2", "start": 77, "end": 81}]}}, "schema": []}
{"input": "Refugees living in Lund and repatriated to Chile considered their health as bad in a higher proportion than their Swedish counterparts, with an odds ratio of 3. 48 (2. 03-5. 66) and 4. 78 (2. 1-10. 25) respectively.", "output": {"entities": {}}, "schema": []}
{"input": "This study underlines the importance of terminal SC5b-9 complement complex as a suitable marker in the evaluation of complement activation during cardiopulmonary bypass.", "output": {"entities": {"gene": [{"text": "SC5b-9 complement complex", "start": 49, "end": 74}]}}, "schema": []}
{"input": "Striking sequence similarities (57 and 53%) were observed with yeast mitochondrial proteins, SMF1 and SMF2, especially within putative functional domains: exon 6 encoding the second transmembrane spanning domain, site of the murine susceptibility mutation; and exon 11 encoding a conserved transport motif.", "output": {"entities": {"gene": [{"text": "SMF1", "start": 93, "end": 97}, {"text": "SMF2", "start": 102, "end": 106}, {"text": "murine susceptibility", "start": 225, "end": 246}]}}, "schema": []}
{"input": "Furthermore, we have identified a soluble form of ERp57/GRP58 by Western blotting and biosynthetic labeling.", "output": {"entities": {"gene": [{"text": "ERp57", "start": 50, "end": 55}, {"text": "GRP58", "start": 56, "end": 61}]}}, "schema": []}
{"input": "Consistent with the hepatic and epidermal expression of histidase, this finding suggests that histidase transcription may be regulated by these factors.", "output": {"entities": {"gene": [{"text": "histidase", "start": 56, "end": 65}, {"text": "histidase", "start": 94, "end": 103}]}}, "schema": []}
{"input": "Unlike ARF, the ARP immunoreactivity was detected in plasma membranes but not in cytosol of fractionated 3T3-L1 cells.", "output": {"entities": {"gene": [{"text": "ARF", "start": 7, "end": 10}, {"text": "ARP", "start": 16, "end": 19}]}}, "schema": []}
{"input": "An infectious origin should always be excluded since specific etiologic therapy may be implemented.", "output": {"entities": {}}, "schema": []}
{"input": "All three NR isoforms are expressed in cv.", "output": {"entities": {"gene": [{"text": "NR isoforms", "start": 10, "end": 21}]}}, "schema": []}
{"input": "All three NR isoforms are expressed in cv.", "output": {"entities": {"gene": [{"text": "NR", "start": 10, "end": 12}]}}, "schema": []}
{"input": "The Arabidopsis FAD7 gene encodes a chloroplast omega-3 fatty acid desaturase that catalyzes the desaturation of lipid-linked dienoic fatty acids (18: 2 and 16: 2).", "output": {"entities": {"gene": [{"text": "Arabidopsis FAD7 gene", "start": 4, "end": 25}, {"text": "chloroplast omega-3 fatty acid desaturase", "start": 36, "end": 77}]}}, "schema": []}
{"input": "Certain transcript patterns in Epifagus plastids are highly complex and similar to those of tobacco operons.", "output": {"entities": {}}, "schema": []}
{"input": "The XS2 gene down-regulates but does not abolish expression of LU genes and does not affect expression of CD44.", "output": {"entities": {"gene": [{"text": "XS2 gene", "start": 4, "end": 12}, {"text": "LU genes", "start": 63, "end": 71}, {"text": "CD44", "start": 106, "end": 110}]}}, "schema": []}
{"input": "Diabetes care: a guideline to the facilities needed to support internationally endorsed standards.", "output": {"entities": {}}, "schema": []}
{"input": "The gene was uniquely mapped with odds > 1, 000: 1 on chromosome 3p in Centre d' Etude du Polymorphisme Humain pedigrees.", "output": {"entities": {}}, "schema": []}
{"input": "Human LAF-4 readily hybridized with genes in mouse and chicken, thus showing that this gene family has been highly conserved during vertebrate evolution.", "output": {"entities": {"gene": [{"text": "Human LAF-4", "start": 0, "end": 11}]}}, "schema": []}
{"input": "Cycles were repeated every 3 weeks.", "output": {"entities": {}}, "schema": []}
{"input": "Upstream of-37, the 5' untranslated sequences of the isolates differ in both length and sequence.", "output": {"entities": {}}, "schema": []}
{"input": "SBF binds to the promoter prior to the activation of transcription in late G1, suggesting that Cln/Cdc28 kinase regulates the ability of previously bound SBF to activate transcription.", "output": {"entities": {"gene": [{"text": "SBF", "start": 0, "end": 3}, {"text": "Cln", "start": 95, "end": 98}, {"text": "Cdc28", "start": 99, "end": 104}, {"text": "SBF", "start": 154, "end": 157}]}}, "schema": []}
{"input": "However, it remains an open question whether vertebrate Hox genes expressed under the control of Drosophila regulatory sequences can substitute the function of Drosophila Hox genes.", "output": {"entities": {"gene": [{"text": "vertebrate Hox genes", "start": 45, "end": 65}, {"text": "Drosophila Hox genes", "start": 160, "end": 180}]}}, "schema": []}
{"input": "This approach places gHoxb-1 into the normal embryonic spatiotemporal context in which lab acts.", "output": {"entities": {"gene": [{"text": "gHoxb-1", "start": 21, "end": 28}]}}, "schema": []}
{"input": "We propose that CTS1 and CTS2 of Ci are members of two distinct classes of fungal chitinases, an observation not previously reported for a single fungus.", "output": {"entities": {"gene": [{"text": "CTS1 and CTS2 of Ci", "start": 16, "end": 35}, {"text": "fungal chitinases", "start": 75, "end": 92}]}}, "schema": []}
{"input": "The purpose of the study reported here was to investigate whether differences in T1 and T2 between tumors are mainly a consequence of differences in the fractional volume of the extracellular compartment.", "output": {"entities": {}}, "schema": []}
{"input": "A mutant areA product truncated immediately after the last residue of the highly conserved GATA (DNA-binding) domain retains partial function.", "output": {"entities": {"gene": [{"text": "mutant areA product", "start": 2, "end": 21}, {"text": "GATA (DNA-binding) domain", "start": 91, "end": 116}]}}, "schema": []}
{"input": "This region contains a motif with partial identity with the binding site for the ubiquitous transcription factor upstream stimulatory factor (USF), which binds to the human insulin promoter.", "output": {"entities": {"gene": [{"text": "upstream stimulatory factor", "start": 113, "end": 140}, {"text": "USF", "start": 142, "end": 145}, {"text": "human insulin promoter", "start": 167, "end": 189}]}}, "schema": []}
{"input": "The Clb5 kinase, which promotes S phase, remains active during the G2-phase arrest of cells of the parental strain, but its activity declines rapidly in sim mutants.", "output": {"entities": {"gene": [{"text": "Clb5 kinase", "start": 4, "end": 15}, {"text": "sim mutants", "start": 153, "end": 164}]}}, "schema": []}
{"input": "The C/D ratio was equal to or over 0. 6 in 9 cases (16 eyes), and the values were inconsistent between both eyes in 55% of the patients.", "output": {"entities": {}}, "schema": []}
{"input": "(1989), which is identical to the SSC1 gene (Smith et al., 1988).", "output": {"entities": {"gene": [{"text": "SSC1 gene", "start": 34, "end": 43}]}}, "schema": []}
{"input": "This region also contains a gene specifying a Leu-tRNA precursor and a remnant of a tau element.", "output": {"entities": {"gene": [{"text": "Leu-tRNA precursor", "start": 46, "end": 64}]}}, "schema": []}
{"input": "Occupational exposure to hepatitis B virus and human immunodeficiency virus: a comparative risk analysis.", "output": {"entities": {}}, "schema": []}
{"input": "In these constructs, GUS expression was driven by promoter regions derived from the Arabidopsis alcohol dehydrogenase (Adh1), maize ubiquitin (Ubi1), rice actin (Act1) and CaMV 35S genes.", "output": {"entities": {"gene": [{"text": "GUS", "start": 21, "end": 24}, {"text": "Arabidopsis alcohol dehydrogenase", "start": 84, "end": 117}, {"text": "Adh1", "start": 119, "end": 123}, {"text": "maize ubiquitin", "start": 126, "end": 141}, {"text": "Ubi1", "start": 143, "end": 147}, {"text": "rice actin", "start": 150, "end": 160}, {"text": "Act1", "start": 162, "end": 166}, {"text": "CaMV 35S genes", "start": 172, "end": 186}]}}, "schema": []}
{"input": "Its organization and regulation indicate that the S. pombe URA1 gene product appears very similar to the S. cerevisiae URA2 gene product.", "output": {"entities": {"gene": [{"text": "S. pombe URA1 gene product", "start": 50, "end": 76}, {"text": "S. cerevisiae URA2 gene product", "start": 105, "end": 136}]}}, "schema": []}
{"input": "(ii) opening of KATP attenuates, inhibition of the channel exacerbates functional consequences of coronary occlusion, and (iii) KATP opening attenuates reperfusion-induced VF, but it triggers ischemia-induced VF.", "output": {"entities": {}}, "schema": []}
{"input": "Effects of repeated exposures of hydrogen sulphide on rat hippocampal EEG.", "output": {"entities": {}}, "schema": []}
{"input": "Pseudomembranous conjunctivitis following bone marrow transplantation: immunopathological and ultrastructural study of one case.", "output": {"entities": {}}, "schema": []}
{"input": "In view of the presence of SECIS elements in the open reading frames (ORFs) of bacterial selenoproteins, we examine the effects in the type 1 deiodinase of extending the ORF into the SECIS element, and find that this dramatically inhibits SECIS function.", "output": {"entities": {"gene": [{"text": "bacterial selenoproteins", "start": 79, "end": 103}, {"text": "type 1 deiodinase", "start": 135, "end": 152}]}}, "schema": []}
{"input": "This spindle defect of pds1 mutants results from a temperature-sensitive step that occurs around the G1/S boundary about the time of spindle assembly.", "output": {"entities": {"gene": [{"text": "pds1 mutants", "start": 23, "end": 35}]}}, "schema": []}
{"input": "In the point mutant we observed normal repair of endonuclease III site (i. e. as wild type), but no removal of CPDs at the MAT alpha and HML alpha loci.", "output": {"entities": {"gene": [{"text": "endonuclease III site", "start": 49, "end": 70}, {"text": "MAT alpha", "start": 123, "end": 132}, {"text": "HML alpha loci", "start": 137, "end": 151}]}}, "schema": []}
{"input": "However, for the evaluable cases, the performances of the CD3500 and the STKS were broadly similar and generally correlated well with the manual reference procedure.", "output": {"entities": {}}, "schema": []}
{"input": "In conclusion, IgM class CIC is the predominant CIC in acute hepatitis A and correlated with disease activity.", "output": {"entities": {"gene": [{"text": "IgM", "start": 15, "end": 18}]}}, "schema": []}
{"input": "Left atrial volumes were greater in old compared with young subjects (maximal: 31 +/-10 cm3/m2 vs 24 +/-8 cm3/m2, p = 0. 02; at onset of atrial systole: 23 +/-8 cm3/m2 vs 15 +/-5 cm3/m2, p = 0. 0002; minimal: 13 +/-5 cm3/m2 vs 9 +/-4 cm3/m2, p = 0. 001).", "output": {"entities": {}}, "schema": []}
{"input": "We observed abundant levels of Rev-erbA alpha mRNA in dividing C2C12 myoblasts, which were suppressed when the cells differentiated into postmitotic multinucleated myotubes.", "output": {"entities": {"gene": [{"text": "Rev", "start": 31, "end": 34}, {"text": "erbA alpha", "start": 35, "end": 45}]}}, "schema": []}
{"input": "We then demonstrated that 1) GAL4-REV-erbA alpha chimeras that contain the' AB' region and lack the' E' region activated transcription of GAL4 response elements in the presence of 8-Br-cAMP and 2) the ligand-binding domain (LBD) contains an active transcriptional silencer.", "output": {"entities": {"gene": [{"text": "GAL4", "start": 29, "end": 33}, {"text": "REV", "start": 34, "end": 37}, {"text": "erbA alpha", "start": 38, "end": 48}, {"text": "GAL4 response elements", "start": 138, "end": 160}]}}, "schema": []}
{"input": "TNF Treatment of cell activated the p38 MAP kinase pathway, as revealed by increased phosphorylation of p38 MAP kinase itself, activation of the substrate protein MAPKAP kinase-2, and culminating in the phosphorylation of the heat shock protein 27 (hsp27).", "output": {"entities": {"gene": [{"text": "TNF", "start": 0, "end": 3}, {"text": "p38 MAP kinase", "start": 36, "end": 50}, {"text": "p38 MAP kinase", "start": 104, "end": 118}, {"text": "MAPKAP kinase-2", "start": 163, "end": 178}, {"text": "heat shock protein 27", "start": 226, "end": 247}, {"text": "hsp27", "start": 249, "end": 254}]}}, "schema": []}
{"input": "However, while the sequence similarity between the membrane exons of avian mIgY and mammalian mIgG and IgE is striking, the overall similarity with Xenopus mIgY is very low.", "output": {"entities": {"gene": [{"text": "avian mIgY", "start": 69, "end": 79}, {"text": "mammalian mIgG and IgE", "start": 84, "end": 106}, {"text": "Xenopus mIgY", "start": 148, "end": 160}]}}, "schema": []}
{"input": "The novel hematopoietic growth factor FLT3 ligand (FL) is the cognate ligand for the FLT3, tyrosine kinase receptor (R), also referred to as FLK-2 and STK-1.", "output": {"entities": {"gene": [{"text": "hematopoietic growth factor FLT3 ligand", "start": 10, "end": 49}, {"text": "FL", "start": 51, "end": 53}, {"text": "FLT3", "start": 85, "end": 89}, {"text": "tyrosine kinase receptor", "start": 91, "end": 115}, {"text": "R", "start": 117, "end": 118}, {"text": "FLK-2", "start": 141, "end": 146}, {"text": "STK-1", "start": 151, "end": 156}]}}, "schema": []}
{"input": "In contrast to the selective expression of the receptor, FL expression was detected in 90-100% of the various cell types of leukemia cell lines from all hematopoietic cell lineages.", "output": {"entities": {"gene": [{"text": "FL", "start": 57, "end": 59}]}}, "schema": []}
{"input": "LY290181 appears to inhibit uPA promoter activation by blocking phorbol ester-stimulated binding of nuclear proteins to the uPA PEA3/12-0-tetradecanoylphorbol 13-acetate responsive element (TRE).", "output": {"entities": {"gene": [{"text": "uPA promoter", "start": 28, "end": 40}, {"text": "uPA PEA3", "start": 124, "end": 132}]}}, "schema": []}
{"input": "The protein folds correctly with two disulfide bonds and a free thiol group at Cys25.", "output": {"entities": {}}, "schema": []}
{"input": "No significant differences existed between the two age groups in baseline characteristics, including treatment protocol, performance status, and serum lactate dehydrogenase (LDH) level.", "output": {"entities": {"gene": [{"text": "serum lactate dehydrogenase", "start": 145, "end": 172}, {"text": "LDH", "start": 174, "end": 177}]}}, "schema": []}
{"input": "Conversely, when VDR is overexpressed, vitamin D3 attenuates 9-cis RA induction from an RXR-responsive element.", "output": {"entities": {"gene": [{"text": "VDR", "start": 17, "end": 20}, {"text": "RXR", "start": 88, "end": 91}]}}, "schema": []}
{"input": "Mutations within conserved region 2 (CR2) of E1A that inhibit the binding of E1A to the retinoblastoma gene product (pRb) further enhanced the stimulation of transcription from the PEPCK promoter by 2 3-fold compared with wild type E1A.", "output": {"entities": {"gene": [{"text": "E1A", "start": 45, "end": 48}, {"text": "E1A", "start": 77, "end": 80}, {"text": "retinoblastoma gene product", "start": 88, "end": 115}, {"text": "pRb", "start": 117, "end": 120}, {"text": "PEPCK promoter", "start": 181, "end": 195}, {"text": "wild type E1A", "start": 222, "end": 235}]}}, "schema": []}
{"input": "Using autoantibodies from a Sjogren' s syndrome patient, we have previously identified a 230-kDa peripheral membrane protein associated with the cytosolic face of the trans-Golgi (Kooy, J., Toh, B.", "output": {"entities": {}}, "schema": []}
{"input": "Apart from two proline-rich regions (amino acids 1-117 and 239-270), p230 contains a very high frequency of heptad repeats, characteristic of alpha-helices that form dimeric coiled-coil structures. p230 also includes the sequence ESLALEELEL (amino acids 538-546), a motif found in the granin family of acidic proteins present in secretory granules of neuroendocrine cells.", "output": {"entities": {"gene": [{"text": "p230", "start": 69, "end": 73}, {"text": "p230", "start": 198, "end": 202}, {"text": "granin family", "start": 285, "end": 298}]}}, "schema": []}
{"input": "They were found to stimulate at nanomolar concentrations the turnover of biosynthetically labeled ceramide, glucosylceramide, and lactosylceramide.", "output": {"entities": {}}, "schema": []}
{"input": "These findings suggest that the increase in V O2 may have been a consequence of the increase in Q O2 rather than a response to the procedure itself.", "output": {"entities": {}}, "schema": []}
{"input": "Consistent with ErbB-2 being a shared receptor subunit, its tyrosine phosphorylation was increased by both heterologous ligands and it mediated a trans-inhibitory effect of NDF on EGF binding.", "output": {"entities": {"gene": [{"text": "ErbB-2", "start": 16, "end": 22}, {"text": "NDF", "start": 173, "end": 176}, {"text": "EGF", "start": 180, "end": 183}]}}, "schema": []}
{"input": "Identification of a consensus cyclin-dependent kinase phosphorylation site unique to the nuclear form of human deoxyuridine triphosphate nucleotidohydrolase.", "output": {"entities": {"gene": [{"text": "cyclin-dependent kinase phosphorylation site", "start": 30, "end": 74}, {"text": "human deoxyuridine triphosphate nucleotidohydrolase", "start": 105, "end": 156}]}}, "schema": []}
{"input": "VDR/RXR bound well to the VDREs and to DR4 and DR5 using the electrophoretic mobility shift assay.", "output": {"entities": {"gene": [{"text": "VDR", "start": 0, "end": 3}, {"text": "RXR", "start": 4, "end": 7}]}}, "schema": []}
{"input": "The sequence and isolated cDNAs will provide useful reagents for studying the expression of Brca1 in the mouse, and for testing the importance of the evolutionarily conserved domains.", "output": {"entities": {"gene": [{"text": "Brca1", "start": 92, "end": 97}]}}, "schema": []}
{"input": "A study was performed to compare the ONLINE and EMIT II immunoassays with gas chromatographic/mass spectrometric (GC/MS) analysis of methaqualone metabolites on urine using samples obtained from a clinical study.", "output": {"entities": {}}, "schema": []}
{"input": "Isolation by PCR of a cDNA clone from pea petals with similarity to petunia and wheat zinc finger proteins.", "output": {"entities": {"gene": [{"text": "wheat zinc finger proteins", "start": 80, "end": 106}]}}, "schema": []}
{"input": "Exposure of peripheral blood T cells from young subjects to PHA or cross-linked anti-CD3 monoclonal antibodies stimulated rapid increases in MAPK and MEK enzymatic activity.", "output": {"entities": {"gene": [{"text": "PHA", "start": 60, "end": 63}, {"text": "anti-CD3 monoclonal antibodies", "start": 80, "end": 110}, {"text": "MAPK", "start": 141, "end": 145}, {"text": "MEK", "start": 150, "end": 153}]}}, "schema": []}
{"input": "Deletion analysis of rOC promoter-chloramphenicol acetyltransferase constructs demonstrates that an AML-1-binding sequence within the proximal promoter (-138 to-130 nt) contributes to 75% of the level of osteocalcin gene expression.", "output": {"entities": {"gene": [{"text": "rOC promoter", "start": 21, "end": 33}, {"text": "chloramphenicol acetyltransferase", "start": 34, "end": 67}, {"text": "AML-1-binding sequence", "start": 100, "end": 122}, {"text": "osteocalcin gene", "start": 204, "end": 220}]}}, "schema": []}
{"input": "Escherichia coli BL21 (DE3) plysS, harbouring a recombinant plasmid containing the catalase-peroxidase gene, produced a large amount of proteins that co-migrated on SDS/PAGE with the native enzyme.", "output": {"entities": {"gene": [{"text": "catalase", "start": 83, "end": 91}, {"text": "peroxidase", "start": 92, "end": 102}]}}, "schema": []}
{"input": "Cdk2 formed a complex with cyclin D1 in this system.", "output": {"entities": {"gene": [{"text": "Cdk2", "start": 0, "end": 4}, {"text": "cyclin D1", "start": 27, "end": 36}]}}, "schema": []}
{"input": "The Cdk2-cyclin-D1 complex did not phosphorylate any tested substrates, such as H1 histone, pRB, SV40 large T antigen, p53, E2F-1 or a preparation of nuclear proteins from HeLa cells; in contrast, Cdk2-cyclin-E and Cdk2-cyclin-A phosphorylated these proteins.", "output": {"entities": {"gene": [{"text": "Cdk2", "start": 4, "end": 8}, {"text": "cyclin-D1", "start": 9, "end": 18}, {"text": "H1 histone", "start": 80, "end": 90}, {"text": "pRB", "start": 92, "end": 95}, {"text": "SV40 large T antigen", "start": 97, "end": 117}, {"text": "p53", "start": 119, "end": 122}, {"text": "E2F-1", "start": 124, "end": 129}, {"text": "Cdk2", "start": 197, "end": 201}, {"text": "cyclin-E", "start": 202, "end": 210}, {"text": "Cdk2", "start": 215, "end": 219}, {"text": "cyclin-A", "start": 220, "end": 228}]}}, "schema": []}
{"input": "Cyclin-dependent kinase-2 (Cdk2) forms an inactive complex with cyclin D1 since Cdk2 associated with cyclin D1 is not phosphorylated by Cdk7-cyclin-H.", "output": {"entities": {"gene": [{"text": "Cyclin-dependent kinase-2", "start": 0, "end": 25}, {"text": "Cdk2", "start": 27, "end": 31}, {"text": "cyclin D1", "start": 64, "end": 73}, {"text": "Cdk2", "start": 80, "end": 84}, {"text": "cyclin D1", "start": 101, "end": 110}, {"text": "Cdk7", "start": 136, "end": 140}, {"text": "cyclin-H", "start": 141, "end": 149}]}}, "schema": []}
{"input": "A human cytoplasmic signaling protein has been cloned that possesses the same structural arrangement of SH3-SH2-SH3 domains as Grb2.", "output": {"entities": {"gene": [{"text": "SH3", "start": 104, "end": 107}, {"text": "SH2", "start": 108, "end": 111}, {"text": "SH3", "start": 112, "end": 115}, {"text": "Grb2", "start": 127, "end": 131}]}}, "schema": []}
{"input": "Cloning of individual ZI domains upstream of a minimal promoter demonstrated that the ZIA, ZIC, and ZID domains, but not the ZIB domain, are TPA responsive.", "output": {"entities": {}}, "schema": []}
{"input": "Sp1 binds two sites in the CD11c promoter in vivo specifically in myeloid cells and cooperates with AP1 to activate transcription.", "output": {"entities": {"gene": [{"text": "Sp1", "start": 0, "end": 3}, {"text": "CD11c promoter", "start": 27, "end": 41}, {"text": "AP1", "start": 100, "end": 103}]}}, "schema": []}
{"input": "We found that 120 bp of the enhancer' s transcriptional core becomes DNase I hypersensitive early in B-cell development.", "output": {"entities": {"gene": [{"text": "DNase I", "start": 69, "end": 76}]}}, "schema": []}
{"input": "A developmentally modulated chromatin structure at the mouse immunoglobulin kappa 3' enhancer.", "output": {"entities": {"gene": [{"text": "mouse immunoglobulin kappa 3' enhancer", "start": 55, "end": 93}]}}, "schema": []}
{"input": "Heme oxygenase 1 is an essential enzyme in heme catabolism that cleaves heme to form biliverdin, iron, and carbon monoxide.", "output": {"entities": {"gene": [{"text": "Heme oxygenase 1", "start": 0, "end": 16}]}}, "schema": []}
{"input": "An inactive analog of wortmannin, WM12, did not affect TCR/CD3-induced Erk2 activation, and wortmannin had no effect on the activity of Erk2 when added directly to the in vitro assays.", "output": {"entities": {"gene": [{"text": "TCR", "start": 55, "end": 58}, {"text": "CD3", "start": 59, "end": 62}, {"text": "Erk2", "start": 71, "end": 75}, {"text": "Erk2", "start": 136, "end": 140}]}}, "schema": []}
{"input": "Defects in the Schizosaccharomyces pombe (Sp) cell cycle-controlling genes prevent the cell cycle progression.", "output": {"entities": {}}, "schema": []}
{"input": "To determine the signal recognition particle (SRP)-SRP receptor (Srb) system in Bacillus subtilis (Bs), we cloned the Bs srb gene, which encodes a homologue of the mammalian SRP receptor alpha-subunit [Oguro et al., DNA Res.", "output": {"entities": {"gene": [{"text": "signal recognition particle", "start": 17, "end": 44}, {"text": "SRP", "start": 46, "end": 49}, {"text": "SRP receptor", "start": 51, "end": 63}, {"text": "Srb", "start": 65, "end": 68}, {"text": "Bs srb gene", "start": 118, "end": 129}, {"text": "mammalian SRP receptor alpha-subunit", "start": 164, "end": 200}]}}, "schema": []}
{"input": "Promoter activity was high in cell lines that expressed high levels of endogenous D3 mRNA, as indicated by Northern blot analyses, and was significantly reduced when the promoter was truncated to-122 bp.", "output": {"entities": {"gene": [{"text": "D3 mRNA", "start": 82, "end": 89}]}}, "schema": []}
{"input": "This phenomenon did not require DNA binding by the \" interfering \" receptor but required it to be hormone-bound, indicating that a transcriptionally active form of the interfering receptor is essential for the interfering effect.", "output": {"entities": {}}, "schema": []}
{"input": "A cis-acting DNA element located between TATA box and transcription initiation site is critical in response to regulatory sequences in human angiotensinogen gene.", "output": {"entities": {"gene": [{"text": "angiotensinogen gene", "start": 141, "end": 161}]}}, "schema": []}
{"input": "The promoter of the rat PGS-2 gene contains a CAAT enhancer-binding protein consensus site (CAAT box) which can confer hormone inducibility to a PGS-2. CAT reporter gene, as well as a putative E-box region.", "output": {"entities": {"gene": [{"text": "rat PGS-2 gene", "start": 20, "end": 34}, {"text": "CAAT enhancer-binding protein consensus site (CAAT box)", "start": 46, "end": 101}, {"text": "PGS-2", "start": 145, "end": 150}, {"text": "CAT", "start": 152, "end": 155}]}}, "schema": []}
{"input": "SETTING--Delhi, urban India, 1985-6.", "output": {"entities": {}}, "schema": []}
{"input": "Selective translation initiation by ribosome jumping in adenovirus-infected and heat-shocked cells.", "output": {"entities": {}}, "schema": []}
{"input": "Furthermore, we have identified a 43-bp region of the 24p3 promoter required for the Dex responsiveness.", "output": {"entities": {"gene": [{"text": "24p3 promoter", "start": 54, "end": 67}]}}, "schema": []}
{"input": "Our data demonstrate directly that Rpm1r is transcribed with its substrates, tRNA met f and tRNAPro, from a promoter located upstream of the tRNA met f gene and suggest that a portion also originates from a second promoter, located between the tRNA met f gene and RPM1.", "output": {"entities": {"gene": [{"text": "Rpm1r", "start": 35, "end": 40}, {"text": "tRNA met f", "start": 77, "end": 87}, {"text": "tRNAPro", "start": 92, "end": 99}, {"text": "tRNA met f gene", "start": 141, "end": 156}, {"text": "tRNA met f gene", "start": 244, "end": 259}, {"text": "RPM1", "start": 264, "end": 268}]}}, "schema": []}
{"input": "Furthermore, strains with mutant RPM1 genes also accumulate precursor Rpm1r, suggesting that mutations in either gene can lead to similar biogenesis defects.", "output": {"entities": {"gene": [{"text": "mutant RPM1 genes", "start": 26, "end": 43}, {"text": "precursor Rpm1r", "start": 60, "end": 75}]}}, "schema": []}
{"input": "Merlie, Cold Spring Harbor Symp.", "output": {"entities": {}}, "schema": []}
{"input": "Substantial evidence supports a critical role for the activation of the Raf-1/MEK/mitogen-activated protein kinase pathway in oncogenic Ras-mediated transformation.", "output": {"entities": {"gene": [{"text": "Raf-1", "start": 72, "end": 77}, {"text": "MEK", "start": 78, "end": 81}, {"text": "mitogen-activated protein kinase", "start": 82, "end": 114}, {"text": "Ras", "start": 136, "end": 139}]}}, "schema": []}
{"input": "Stylohyoid chain ossification: choice of the surgical approach.", "output": {"entities": {}}, "schema": []}
{"input": "63. 3 micromol/1, p < 0. 01) and area under the plasma concentration-time curve extrapolated to infinity AUC 9 (0-infinity) (518. 7 vs.", "output": {"entities": {}}, "schema": []}
{"input": "Mean increase of milk protein yield was 46 g/d with Met plus Lys, and mean increase of true protein content was 1. 1 g/kg of milk.", "output": {"entities": {}}, "schema": []}
{"input": "A chimeric VP16-Tat construct containing the leucine mutations showed no increased AP-1 responsiveness in comparison with that of the VP16 activation domain alone.", "output": {"entities": {"gene": [{"text": "VP16", "start": 11, "end": 15}, {"text": "Tat", "start": 16, "end": 19}, {"text": "AP-1", "start": 83, "end": 87}, {"text": "VP16 activation domain", "start": 134, "end": 156}]}}, "schema": []}
{"input": "Despite significant lethality and cardiovascular dysfunction, in the septic group on Days 1 and 2, septic versus control animals had no significant differences in mean metabolic cart measured (Vo2DIR, ml/kg/min; Day 1: 11. 9 versus 12. 4, p = 0. 81; Day 2: 14. 2 versus 13. 5, p = 0. 72, respectively) and intravascular catheter calculated (Vo2INDIR, ml/kg/min; Day 1: 11. 2 versus 11. 2, p = 0. 99; Day 2: 12. 8 versus 15. 4, p = 0. 49, respectively).", "output": {"entities": {}}, "schema": []}
{"input": "Although IL-2 and IFN-alpha activated STAT1 alpha and STAT5, IL-2 predominantly activated STAT5, while IFN-alpha predominantly activated STAT1 alpha.", "output": {"entities": {"gene": [{"text": "IL-2", "start": 9, "end": 13}, {"text": "IFN-alpha", "start": 18, "end": 27}, {"text": "STAT1 alpha", "start": 38, "end": 49}, {"text": "STAT5", "start": 54, "end": 59}, {"text": "IL-2", "start": 61, "end": 65}, {"text": "STAT5", "start": 90, "end": 95}, {"text": "IFN-alpha", "start": 103, "end": 112}, {"text": "STAT1 alpha", "start": 137, "end": 148}]}}, "schema": []}
{"input": "One complex containing a 70 D protein was found to be associated specifically with transcriptionally active leukemia cells.", "output": {"entities": {}}, "schema": []}
{"input": "Our results confirm the participation of intron 1 in transcriptional regulation of the c-myb gene (in mouse and human) and implicate multiple and complex regulatory mechanisms of activation during myelomonocytic differentiation and leukemic cell growth control.", "output": {"entities": {"gene": [{"text": "c-myb gene", "start": 87, "end": 97}]}}, "schema": []}
{"input": "Limited role for PCR-based diagnosis of Whipple' s disease from peripheral blood mononuclear cells.", "output": {"entities": {}}, "schema": []}
{"input": "The Pro-258--> Leu (P258L) mutation caused constitutive receptor signaling that was equivalent to about 45% of the maximum level observed in wild-type cells stimulated with alpha-factor.", "output": {"entities": {"gene": [{"text": "alpha-factor", "start": 173, "end": 185}]}}, "schema": []}
{"input": "CONCLUSIONS: Our findings suggest that pre-treatment with coenzyme Q10 may play a protective role during routine vascular procedures requiring abdominal aortic cross clamping by attenuating the degree of peroxidative damage.", "output": {"entities": {}}, "schema": []}
{"input": "In a screen for genes with oncogenic potential expressed by the murine B6SUtA1 myeloid progenitor cell line, we isolated a 2.", "output": {"entities": {}}, "schema": []}
{"input": "The mechanism involves Gbetagamma subunit-mediated increases in tyrosine phosphorylation of the Shc adapter protein, Shc * Grb2 complex formation, and recruitment of Ras guanine nucleotide exchange factor activity.", "output": {"entities": {"gene": [{"text": "Gbetagamma", "start": 23, "end": 33}, {"text": "Shc adapter protein", "start": 96, "end": 115}, {"text": "Shc", "start": 117, "end": 120}, {"text": "Grb2", "start": 123, "end": 127}, {"text": "Ras guanine nucleotide exchange factor", "start": 166, "end": 204}]}}, "schema": []}
{"input": "The cis-acting elements that control promoter activity include binding sites for transcription factors Sp1 and alphaCbf, a 60-kDa CCAAT box-binding protein.", "output": {"entities": {"gene": [{"text": "Sp1", "start": 103, "end": 106}, {"text": "alphaCbf", "start": 111, "end": 119}, {"text": "60-kDa CCAAT box-binding protein", "start": 123, "end": 155}]}}, "schema": []}
{"input": "There was a general broadening of proton resonances for a three-nucleotide segment centered about the lesion site which resulted in a tentative assignment for the sugar protons of the C7 residue in the spectrum of the adduct duplex.", "output": {"entities": {}}, "schema": []}
{"input": "Using immunogold electron microscopy, we found that p58/p45 and p54 are localized on both sides of the nuclear pore complex, like p62.", "output": {"entities": {"gene": [{"text": "p58", "start": 52, "end": 55}, {"text": "p45", "start": 56, "end": 59}, {"text": "p54", "start": 64, "end": 67}, {"text": "p62", "start": 130, "end": 133}]}}, "schema": []}
{"input": "Transcription initiation sites of the rat II beta-, III beta, and O beta-globin genes were determined to be 52 base pairs (bp) 5'-upstream of the translation initiation codon (ATG), in each gene by primer extension analysis.", "output": {"entities": {"gene": [{"text": "II beta-, III beta, and O beta-globin", "start": 42, "end": 79}]}}, "schema": []}
{"input": "Aggravating process induced by indomethacin on chronic gastric lesion in rat.", "output": {"entities": {}}, "schema": []}
{"input": "We have been studying the interaction of the oncogenic human polyomavirus BK (BKV) with the tumor-suppressor protein p53 to understand the biology of this virus as well as to understand the basic mechanisms of p53 transactivation.", "output": {"entities": {"gene": [{"text": "tumor-suppressor protein p53", "start": 92, "end": 120}, {"text": "p53", "start": 210, "end": 213}]}}, "schema": []}
{"input": "Site S-II also spans a 23 bp sequence containing two tandem consensus binding sites with three base pair mismatches in each and a one base pair deletion.", "output": {"entities": {}}, "schema": []}
{"input": "Unaided attempts to quit smoking are generally unsuccessful.", "output": {"entities": {}}, "schema": []}
{"input": "The experience of the lateral rhinotomy approach in transsphenoidal surgery of acromegaly has been favourable.", "output": {"entities": {}}, "schema": []}
{"input": "Possible relationship between hyperinsulinemia and glomerular hypertrophy in nephrosclerosis.", "output": {"entities": {}}, "schema": []}
{"input": "Blood GSH-Px activity was measured with a spectrophotometer, using a modification of a previously described assay.", "output": {"entities": {"gene": [{"text": "GSH-Px", "start": 6, "end": 12}]}}, "schema": []}
{"input": "The concentrations of vitamin A precursors and vitamin E in the hay were below currently recommended dietary levels for llamas, and alfalfa hay appears to provide an unreliable source of vitamins A and E in this species.", "output": {"entities": {}}, "schema": []}
{"input": "Eight cats infected with H. pylori were used in the study.", "output": {"entities": {}}, "schema": []}
{"input": "However, as determined by PCR with primers specific for the 26-kDa product, the majority of cats at 2 and 4 weeks p. t. had gastric fluid samples which were positive for H. pylori and three of three cats at 2 weeks p. t. had dental plaque which was positive for H. pylori.", "output": {"entities": {}}, "schema": []}
{"input": "The most frequent causes of the meningitis was the external ventricular drainage (14. 8%), post-neurosurgical (0. 8%) and head injury (0. 0007%).", "output": {"entities": {}}, "schema": []}
{"input": "In vitro interaction studies, using proteins fused to glutathione-S-transferase, showed that RBP-J kappa and Su (H) bind directly to the RAM23 regions of mouse Notch1 and Drosophila Notch, respectively.", "output": {"entities": {"gene": [{"text": "glutathione-S-transferase", "start": 54, "end": 79}, {"text": "RBP-J kappa", "start": 93, "end": 104}, {"text": "Su (H)", "start": 109, "end": 115}, {"text": "RAM23 regions", "start": 137, "end": 150}, {"text": "mouse Notch1", "start": 154, "end": 166}, {"text": "Drosophila Notch", "start": 171, "end": 187}]}}, "schema": []}
{"input": "Twelve genomic fragments containing novel response elements are described, and the transcription unit associated with one of them, NN-84AG, was characterized in detail.", "output": {"entities": {"gene": [{"text": "NN-84AG", "start": 131, "end": 138}]}}, "schema": []}
{"input": "Members of the Ras subfamily of small GTP-binding proteins have been shown to be promiscuous towards a variety of putative effector molecules such as the protein kinase c-Raf and the Ral-specific guanine nucleotide exchange factor (Ral-GEF).", "output": {"entities": {"gene": [{"text": "Ras subfamily", "start": 15, "end": 28}, {"text": "small GTP-binding proteins", "start": 32, "end": 58}, {"text": "protein kinase c-Raf", "start": 154, "end": 174}, {"text": "Ral-specific guanine nucleotide exchange factor", "start": 183, "end": 230}, {"text": "Ral-GEF", "start": 232, "end": 239}]}}, "schema": []}
{"input": "The cDNA encoded a mature protein of 240 amino acids, including a 29-amino acid signal sequence.", "output": {"entities": {}}, "schema": []}
{"input": "Biol.", "output": {"entities": {}}, "schema": []}
{"input": "The effect of ligustrazine hydrochloride (LTH) on depressing pulmonary artery hypertension has been proved in recent studies.", "output": {"entities": {}}, "schema": []}
{"input": "In the same period we pointed out an increase of hematocrit (from 29% to 35%) and of the Hb (from 9. 3 to 11. 2 g/dl).", "output": {"entities": {"gene": [{"text": "Hb", "start": 89, "end": 91}]}}, "schema": []}
{"input": "The structure of these genes suggests a common ancestor for all viperid PLA2 genes.", "output": {"entities": {"gene": [{"text": "viperid PLA2 genes", "start": 64, "end": 82}]}}, "schema": []}
{"input": "Chloroplast mutator (chm) of Arabidopsis is a recessive nuclear mutation that causes green and white variegation in leaves and is inherited in a non-Mendelian fashion.", "output": {"entities": {"gene": [{"text": "Chloroplast mutator", "start": 0, "end": 19}, {"text": "chm", "start": 21, "end": 24}]}}, "schema": []}
{"input": "Also like the thrombin receptor, PAR2 can be activated by the hexapeptide corresponding to its tethered ligand sequence independent of receptor cleavage.", "output": {"entities": {"gene": [{"text": "thrombin receptor", "start": 14, "end": 31}, {"text": "PAR2", "start": 33, "end": 37}]}}, "schema": []}
{"input": "Such an increase in the steady-state testicular TIMP-2 mRNA level apparently is not the result of an up-regulation by germ cells because germ cells cocultured with Sertoli cells failed to elicit an increase in the Sertoli cell steady-state TIMP-2 mRNA level.", "output": {"entities": {"gene": [{"text": "testicular TIMP-2 mRNA", "start": 37, "end": 59}, {"text": "TIMP-2 mRNA", "start": 240, "end": 251}]}}, "schema": []}
{"input": "In the SPK and PTA category, anti-T-cell therapy significantly lowered the risk of graft loss.", "output": {"entities": {}}, "schema": []}
{"input": "Five-year survivals amounted to 100%, 86. 2%, 59. 4%, 29. 8%, and 20% for stages I, II, III, IVA and IVB respectively.", "output": {"entities": {}}, "schema": []}
{"input": "Targeted disruption of the OGG1 gene in yeast revealed a second OG glycosylase/lyase protein, tentatively named Ogg2, which differs from Ogg1 in that it preferentially acts on OG: G.", "output": {"entities": {"gene": [{"text": "OGG1 gene", "start": 27, "end": 36}, {"text": "OG glycosylase/lyase protein", "start": 64, "end": 92}, {"text": "Ogg2", "start": 112, "end": 116}, {"text": "Ogg1", "start": 137, "end": 141}]}}, "schema": []}
{"input": "Sequence analysis of the isolated genomic clone revealed that the DNA binding domain of this orphan receptor is most homologous to the human TR2 receptor.", "output": {"entities": {"gene": [{"text": "human TR2 receptor", "start": 135, "end": 153}]}}, "schema": []}
{"input": "Genomic DNA hybridization suggests that SpSHR2 is a single-copy gene in the S. purpuratus genome.", "output": {"entities": {"gene": [{"text": "SpSHR2", "start": 40, "end": 46}]}}, "schema": []}
{"input": "Its hydropathy profile predicts seven transmembrane spans and a hydrophilic amino terminus of approximately 100 residues, and it suggests the presence of an amphiphilic alpha-helix (L-61 to F-97) in close proximity to the first strongly hydrophobic segment of ProW.", "output": {"entities": {"gene": [{"text": "ProW", "start": 260, "end": 264}]}}, "schema": []}
{"input": "There are four polyglutamine motifs interspersed with histidine-rich regions.", "output": {"entities": {}}, "schema": []}
{"input": "Quantitative analysis of plasmid loss rates in cdc28-1N strains carrying plasmids with multiple replication origins suggests that a defect in initiating DNA replication probably causes this plasmid loss phenotype.", "output": {"entities": {"gene": [{"text": "cdc28-1N", "start": 47, "end": 55}]}}, "schema": []}
{"input": "Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity.", "output": {"entities": {"gene": [{"text": "Platelet-derived growth factor", "start": 0, "end": 30}, {"text": "phosphatidylinositol 3-kinase", "start": 55, "end": 84}, {"text": "SH2-domain-containing proteins", "start": 121, "end": 151}, {"text": "Ras", "start": 168, "end": 171}]}}, "schema": []}
{"input": "Almost complete sequence identity was found between the 3' end of the DXS6673E gene and two expressed sequence tags (ESTs) and between the 5' end of the DXS6673E gene and a third EST.", "output": {"entities": {"gene": [{"text": "DXS6673E gene", "start": 70, "end": 83}, {"text": "DXS6673E gene", "start": 153, "end": 166}]}}, "schema": []}
{"input": "Several of the exon boundaries correspond to the boundaries of functional domains in the p55 protein.", "output": {"entities": {"gene": [{"text": "p55 protein", "start": 89, "end": 100}]}}, "schema": []}
{"input": "Tristetraprolin (TTP) is the prototype of a group of potential transcription factors that contain two or more unusual CCCH zinc fingers.", "output": {"entities": {"gene": [{"text": "Tristetraprolin", "start": 0, "end": 15}, {"text": "TTP", "start": 17, "end": 20}]}}, "schema": []}
{"input": "The ewes were returned to normoxia, and monitoring was continued for 1 h.", "output": {"entities": {}}, "schema": []}
{"input": "Feline leukemia viruses (FeLVs), which are replication-competent oncoretroviruses of the domestic cat species, are contagiously transmitted in natural environments.", "output": {"entities": {}}, "schema": []}
{"input": "Both verapamil and propranolol can exhibit additive effects with adenosine in prolonging AV nodal conduction time; however, only verapamil can reduce the dose of adenosine required to produce AV nodal block.", "output": {"entities": {}}, "schema": []}
{"input": "RVR' loss of function' studies by constitutive over-expression of a dominant negative RVR delta E resulted in increased levels of p21Cip1/Waf1 and myogenin mRNAs after serum withdrawal.", "output": {"entities": {"gene": [{"text": "RVR", "start": 0, "end": 3}, {"text": "RVR delta E", "start": 86, "end": 97}, {"text": "p21Cip1", "start": 130, "end": 137}, {"text": "Waf1", "start": 138, "end": 142}, {"text": "myogenin mRNAs", "start": 147, "end": 161}]}}, "schema": []}
{"input": "These two repeat motifs are organized in an extremely well-ordered pattern in each domain, which suggests that SbHRGP3 belongs to a new group of proteins having the repeat motifs of two distinct groups of dicot extensins.", "output": {"entities": {"gene": [{"text": "SbHRGP3", "start": 111, "end": 118}, {"text": "dicot extensins", "start": 205, "end": 220}]}}, "schema": []}
{"input": "Two classes of inactive receptors were identified: one in which both transcriptional activation and dimerization were compromised and a second in which only transcriptional activation was abolished.", "output": {"entities": {}}, "schema": []}
{"input": "Here we localize a transferable 40-amino acid region within the LBDs of RXR, RAR, TR, and chicken ovalbumin upstream promoter transcription factor that is critical for determining identity in the heterodimeric interaction and for high-affinity DNA binding.", "output": {"entities": {"gene": [{"text": "LBDs", "start": 64, "end": 68}, {"text": "RXR", "start": 72, "end": 75}, {"text": "RAR", "start": 77, "end": 80}, {"text": "TR", "start": 82, "end": 84}, {"text": "chicken ovalbumin upstream promoter transcription factor", "start": 90, "end": 146}]}}, "schema": []}
{"input": "OKA and calyculin A do not decrease OCFRE DNA-protein interactions, suggesting that important protein-protein interactions are phosphatase regulated.", "output": {"entities": {"gene": [{"text": "OCFRE", "start": 36, "end": 41}]}}, "schema": []}
{"input": "IMPLICATIONS: Given the small size of this study and the inconsistency of results among the few prospective studies of ovarian cancer conducted to test these associations, replications of these findings are highly desirable.", "output": {"entities": {}}, "schema": []}
{"input": "We have performed toeprinting analyses on repA mRNA of plasmid R1, both free and in duplex with the antisense RNA, CopA.", "output": {"entities": {"gene": [{"text": "repA mRNA", "start": 42, "end": 51}, {"text": "CopA", "start": 115, "end": 119}]}}, "schema": []}
{"input": "Previous work showed that repA (initiator protein) expression requires tap (leader peptide) translation.", "output": {"entities": {"gene": [{"text": "repA", "start": 26, "end": 30}, {"text": "tap", "start": 71, "end": 74}]}}, "schema": []}
{"input": "Tonsillectomy is an effective means of prophylaxis for upper respiratory infection in habitual angina patients.", "output": {"entities": {}}, "schema": []}
{"input": "These results were corroborated in a subsequent study in which 30 hypogonadal men were supplemented with SLT 5 mg three times daily for 6 months.", "output": {"entities": {}}, "schema": []}
{"input": "The elevations achieved by LDEE given s. c. were higher than those achieved after i. p. administration and lasted for longer periods.", "output": {"entities": {}}, "schema": []}
{"input": "Many human viruses are able to develop suitable strategies for modifying apoptosis in virus-infected cells and in virus-primed T cells.", "output": {"entities": {}}, "schema": []}
{"input": "Taken together, these observations indicate that the C-terminal 24 amino acids are sufficient for NodO secretion although the region adjacent to this domain appears to affect secretion efficiency.", "output": {"entities": {"gene": [{"text": "NodO", "start": 98, "end": 102}]}}, "schema": []}
{"input": "The model also predicts that blood flow shunt fraction (Qs/QT) is directly related to the oxygen sine-wave amplitude perturbations transmitted to end-expired air and arterial and mixed-venous blood through two simple equations.", "output": {"entities": {}}, "schema": []}
{"input": "Discrimination between HIV-1 and HIV-2 showed evidence for the presence of HIV-1 only.", "output": {"entities": {}}, "schema": []}
{"input": "However, an intrinsic DNA-binding subunit for HiNF-D was not identified.", "output": {"entities": {"gene": [{"text": "HiNF-D", "start": 46, "end": 52}]}}, "schema": []}
{"input": "The HiNF-D (CDP/cut) complex with the H4 promoter is immunoreactive with antibodies against CDP/cut and pRB but not p107, whereas the CDP/cut complex with a nonhistone promoter (gp91-phox) reacts only with CDP and p107 antibodies.", "output": {"entities": {"gene": [{"text": "HiNF-D", "start": 4, "end": 10}, {"text": "CDP", "start": 12, "end": 15}, {"text": "cut", "start": 16, "end": 19}, {"text": "H4 promoter", "start": 38, "end": 49}, {"text": "CDP", "start": 92, "end": 95}, {"text": "cut", "start": 96, "end": 99}, {"text": "pRB", "start": 104, "end": 107}, {"text": "p107", "start": 116, "end": 120}, {"text": "CDP", "start": 134, "end": 137}, {"text": "cut", "start": 138, "end": 141}, {"text": "gp91", "start": 178, "end": 182}, {"text": "phox", "start": 183, "end": 187}, {"text": "CDP", "start": 206, "end": 209}, {"text": "p107", "start": 214, "end": 218}]}}, "schema": []}
{"input": "Eight-four ACOAs were tested in order to examine the fit of the model to the data by path analysis with LISREL VII.", "output": {"entities": {}}, "schema": []}
{"input": "Using anchored PCR, a VL element rearranged to CL2 was isolated.", "output": {"entities": {"gene": [{"text": "VL element", "start": 22, "end": 32}, {"text": "CL2", "start": 47, "end": 50}]}}, "schema": []}
{"input": "A subset of these DMP1 recognition sequences containing a GGA trinucleotide core can also function as Ets-responsive elements.", "output": {"entities": {"gene": [{"text": "DMP1 recognition sequences", "start": 18, "end": 44}, {"text": "Ets-responsive elements", "start": 102, "end": 125}]}}, "schema": []}
{"input": "In both settings, it can be phosphorylated by cyclin D-dependent kinases, suggesting that its transcriptional activity may normally be regulated through such mechanisms.", "output": {"entities": {"gene": [{"text": "cyclin D-dependent kinases", "start": 46, "end": 72}]}}, "schema": []}
{"input": "Enterococcus faecium strains with vanA-mediated glycopeptide resistance were isolated by enrichment culture from the intestines and feces of several animal species, mainly horses and dogs (8% positive), chickens (7% positive), and pigs (6% positive).", "output": {"entities": {}}, "schema": []}
{"input": "Oncogenic activation of the tyrosine kinase domain of the human trk proto-oncogene by fusion to a cell adhesion molecule.", "output": {"entities": {"gene": [{"text": "tyrosine kinase domain", "start": 28, "end": 50}, {"text": "human trk proto-oncogene", "start": 58, "end": 82}]}}, "schema": []}
{"input": "Physiol.", "output": {"entities": {}}, "schema": []}
{"input": "They suggest that decreased steady-state levels of IME1 and IME2 mRNA were not merely the result of non-specific adverse affects on nucleic acid metabolism caused by the yvh1 disruption.", "output": {"entities": {"gene": [{"text": "IME1", "start": 51, "end": 55}, {"text": "IME2 mRNA", "start": 60, "end": 69}, {"text": "yvh1", "start": 170, "end": 174}]}}, "schema": []}
{"input": "RNase protection analysis of two rRNA fragments whose genes are adjacent provided evidence for a polycistronic transcript containing sequences from both, as well as separate small RNAs.", "output": {"entities": {"gene": [{"text": "RNase", "start": 0, "end": 5}]}}, "schema": []}
{"input": "These two contigs contain a total of 163 open reading frames (ORFs) in 26-29 putative operons; 56 ORFs could be identified with reasonable certainty.", "output": {"entities": {}}, "schema": []}
{"input": "The evidence in support of this was derived from the fact that the affinity or interaction between the two subunits was impaired as indicated by the first order rate constant of hCG alpha 1 beta (km = 4. 1 x 10 (-2) min-1) at pH 3. 0 at 23 degrees C which is one order of magnitude greater relative to rehCG (kw = 4. 6 x 10 (-3) min-1).", "output": {"entities": {"gene": [{"text": "hCG alpha 1 beta", "start": 178, "end": 194}, {"text": "rehCG", "start": 302, "end": 307}]}}, "schema": []}
{"input": "Rifabutin has substantial efficacy when combined with other agents.", "output": {"entities": {}}, "schema": []}
{"input": "Leukemia-inhibitory factor (LIF) is a neuropoietin able to regulate the differentiation and the survival of many cell types, which include some neuronal populations.", "output": {"entities": {"gene": [{"text": "Leukemia-inhibitory factor", "start": 0, "end": 26}, {"text": "LIF", "start": 28, "end": 31}, {"text": "neuropoietin", "start": 38, "end": 50}]}}, "schema": []}
{"input": "Paracrine activation of the HIV-1 LTR promoter by the viral Tat protein is mechanistically similar to trans-activation within a cell.", "output": {"entities": {"gene": [{"text": "HIV-1 LTR promoter", "start": 28, "end": 46}, {"text": "viral Tat protein", "start": 54, "end": 71}]}}, "schema": []}
{"input": "RUSH-1 beta is a 95-kDa truncated version of RUSH-1 alpha that results from alternative splicing of a 57-bp exon as confirmed by genomic cloning.", "output": {"entities": {"gene": [{"text": "RUSH-1 beta", "start": 0, "end": 11}, {"text": "RUSH-1 alpha", "start": 45, "end": 57}]}}, "schema": []}
{"input": "The mobility shift assay of the 65 bp (-318/-254) fragment with nuclear extract from the dark-adapted sample showed an additional band, not seen with the light-grown sample.", "output": {"entities": {}}, "schema": []}
{"input": "Moreover, the same mutations alter the structure of junB 5' flanking DNA within chromatin.", "output": {"entities": {"gene": [{"text": "junB", "start": 52, "end": 56}]}}, "schema": []}
{"input": "RESULTS: The age distribution was 28 to 83 years old (mean was 54. 1 years).", "output": {"entities": {}}, "schema": []}
{"input": "The ERH expression profile is similar, to that of An3, which localizes to the animal hemisphere of oocytes and is abundantly expressed in the embryo.", "output": {"entities": {"gene": [{"text": "ERH", "start": 4, "end": 7}, {"text": "An3", "start": 50, "end": 53}]}}, "schema": []}
{"input": "When the degree of exercise was maximal, mPAP was maintained, SVI decreased, HR was unchanged, and CO and VO2 decreased.", "output": {"entities": {}}, "schema": []}
{"input": "327 and 736 protocols of postmortem examinations from Moscow hospitals N 31 and 57, respectively, were evaluated statistically.", "output": {"entities": {}}, "schema": []}
{"input": "The effect of six arginine mutations of oxidative phosphorylation and AAC expression.", "output": {"entities": {"gene": [{"text": "AAC", "start": 70, "end": 73}]}}, "schema": []}
{"input": "The RI alpha gene is composed of nine coding exons of varying lengths, separated by introns, giving the gene a total length of at least 21 kb. our recent cloning of a processed RI alpha pseudogene with a 5'-noncoding region different from the previously reported RI alpha complementary RNA indicated that the RI alpha gene may have multiple leader exons giving rise to alternately spliced messenger RNAs (mRNAs).", "output": {"entities": {"gene": [{"text": "RI alpha gene", "start": 4, "end": 17}, {"text": "RI alpha pseudogene", "start": 177, "end": 196}, {"text": "RI alpha complementary RNA", "start": 263, "end": 289}, {"text": "RI alpha gene", "start": 309, "end": 322}]}}, "schema": []}
{"input": "This establishes Rad3/Mec1 as the only conserved protein which is required for all the DNA structure checkpoints in both yeast model systems.", "output": {"entities": {"gene": [{"text": "Rad3", "start": 17, "end": 21}, {"text": "Mec1", "start": 22, "end": 26}]}}, "schema": []}
{"input": "The identification of the hepatitis C virus as the major cause of liver disease both in dialysis patients and in transplant patients has focused attention on the epidemiology and the impact of continuing infection in these patient groups.", "output": {"entities": {}}, "schema": []}
{"input": "Stable transfection of the BL cell line Raji with constructs containing core promoter mutations confirmed that the proximal Sp1 site and the TATA box are essential for the activation of promoter P1 by the Ig kappa enhancers.", "output": {"entities": {"gene": [{"text": "Sp1 site", "start": 124, "end": 132}, {"text": "Ig kappa enhancers", "start": 205, "end": 223}]}}, "schema": []}
{"input": "The first identification of the active 37LRP/p40 gene presented in this study is a critical step toward the isolation of the corresponding human gene and the understanding of the molecular mechanisms involved in the up-regulation of its expression during tumor invasion and metastasis.", "output": {"entities": {"gene": [{"text": "37LRP", "start": 39, "end": 44}, {"text": "p40", "start": 45, "end": 48}]}}, "schema": []}
{"input": "The promoter region (P1) corresponding to the main group of transcription initiation sites is devoid of TATA and CAAT boxes but has putative binding sites for the transcription factor SP1 and is embedded in a large G + C-rich domain of a CpG island, features shared by the promoters of constitutively expressed housekeeping genes.", "output": {"entities": {"gene": [{"text": "transcription factor SP1", "start": 163, "end": 187}]}}, "schema": []}
{"input": "The STAT-1 signaling pathway provides at least one mechanism for activation of the CAEV LTR by IFN-gamma in monocytes.", "output": {"entities": {"gene": [{"text": "STAT-1", "start": 4, "end": 10}, {"text": "CAEV LTR", "start": 83, "end": 91}, {"text": "IFN-gamma", "start": 95, "end": 104}]}}, "schema": []}
{"input": "Unlike wild-type p53, the delta proAE mutant cDNA can be stably expressed in tumor derived cell lines with few immediate detrimental effects.", "output": {"entities": {"gene": [{"text": "wild-type p53", "start": 7, "end": 20}, {"text": "delta proAE mutant cDNA", "start": 26, "end": 49}]}}, "schema": []}
{"input": "Several artifacts occurred that interfered with visualization of the diaphragm.", "output": {"entities": {}}, "schema": []}
{"input": "During skeletal muscle development, different types of muscle fibers are generated, which express different combinations of muscle-specific gene products.", "output": {"entities": {}}, "schema": []}
{"input": "Its transcription product, a 1. 3 kb mRNA, is polyadenylated at a site containing consensus eukaryotic polyadenylation signals and mapping 87 bp downstream of the translation termination codon for CG30.", "output": {"entities": {"gene": [{"text": "CG30", "start": 197, "end": 201}]}}, "schema": []}
{"input": "BCL-2, an inhibitor of apoptosis in a wide variety of cell types, has been reported to prevent oxidative stress-induced cell death.", "output": {"entities": {"gene": [{"text": "BCL-2", "start": 0, "end": 5}]}}, "schema": []}
{"input": "Full-length AT-PHH1, and both AT-PHH1 and AT-PHH1 delta C-513 (truncated to be approximately the size of microbial photolyase genes) cDNAs, were overexpressed, respectively, in yeast and Escherichia coli mutants hypersensitive to ultraviolet light.", "output": {"entities": {"gene": [{"text": "Full-length AT-PHH1", "start": 0, "end": 19}, {"text": "AT-PHH1", "start": 30, "end": 37}, {"text": "AT-PHH1 delta C-513", "start": 42, "end": 61}, {"text": "microbial photolyase genes", "start": 105, "end": 131}]}}, "schema": []}
{"input": "Serotonin concentration in the blood of patients with hemorrhagic fever with renal syndrome", "output": {"entities": {}}, "schema": []}
{"input": "Control examination was performed at the end of each period.", "output": {"entities": {}}, "schema": []}
{"input": "The total number of specimens was 131 with 78 nonsmokers and 53 smokers.", "output": {"entities": {}}, "schema": []}
{"input": "In Experiment 1, pups that had received an injection of the noncompetitive N-methyl-D-aspartate receptor antagonist MK-801 (0. 1 mg/kg, i. p.) either 30 min before or immediately after conditioning spent less time over the conditioned odor than saline-treated controls.", "output": {"entities": {"gene": [{"text": "N-methyl-D-aspartate receptor", "start": 75, "end": 104}]}}, "schema": []}
{"input": "Serotonin receptors in suicide victims with major depression.", "output": {"entities": {"gene": [{"text": "Serotonin receptors", "start": 0, "end": 19}]}}, "schema": []}
{"input": "Experimental data showed that these abnormal proteins are constitutively localized in the nucleus, have lost the transcriptional repressor functions typical of normal NF-kappa B2p52 and may be capable of transactivation activity.", "output": {"entities": {"gene": [{"text": "NF-kappa B2p52", "start": 167, "end": 181}]}}, "schema": []}
{"input": "Because L-plastin expression in tissue-specifically regulated in both humans and rodents, it is likely that similar mechanisms regulate L-plastin gene expression in human and rodent cells and that they could be identified by comparing the function and nucleotide sequences of the human and murine L-plastin gene promoters.", "output": {"entities": {"gene": [{"text": "L-plastin", "start": 8, "end": 17}, {"text": "L-plastin gene", "start": 136, "end": 150}, {"text": "L-plastin", "start": 297, "end": 306}]}}, "schema": []}
{"input": "How does a nurse go about maintaining her level of competence when she is one of the few local practitioners in her field? Vancouver sex therapist Bianca Rucker is doing it by cultivating a network of colleagues and mentors in related fields both at home and across the continent.", "output": {"entities": {}}, "schema": []}
{"input": "Finally, antibody binding to site IIIa on the hCG-ectodomain complex was also hindered by an anti-peptide mAb directed against a peptide encoded by the eighth exon (pE x 8) of the LHR.", "output": {"entities": {"gene": [{"text": "hCG-ectodomain complex", "start": 46, "end": 68}, {"text": "LHR", "start": 180, "end": 183}]}}, "schema": []}
{"input": "In rlf2 mutants, telomeric chromatin is perturbed: Telomeric silencing is reduced and Rap1p localization is altered.", "output": {"entities": {"gene": [{"text": "rlf2 mutants", "start": 3, "end": 15}, {"text": "Rap1p", "start": 86, "end": 91}]}}, "schema": []}
{"input": "This 0. 74 kb cDNA contains an open reading frame (ORF) of 477 bp encoding a polypeptide of 159 amino acids (aa) which differs at only one position (position 65) from the human U1-C protein.", "output": {"entities": {"gene": [{"text": "human U1-C protein", "start": 171, "end": 189}]}}, "schema": []}
{"input": "However, the action of each cognate ligand and the accessory cellular factors that can differentially regulate the transcriptional responses of a heterodimer-DNA complex are not well understood.", "output": {"entities": {}}, "schema": []}
{"input": "We have measured the MBF on incisors and its direction in three dimensions for different jaw openings in ten subjects.", "output": {"entities": {}}, "schema": []}
{"input": "Clinically meaningful decreases due to alkalinization alone within 30 minutes are unlikely.", "output": {"entities": {}}, "schema": []}
{"input": "In co-transfection studies, an AP-2 but not an Egr-1 expression vector activated VPF/VEGF transcription, thus indicating that AP-2 protein is functionally important in TGF alpha-induced VPF/VEGF gene expression.", "output": {"entities": {"gene": [{"text": "AP-2", "start": 31, "end": 35}, {"text": "Egr-1", "start": 47, "end": 52}, {"text": "VPF", "start": 81, "end": 84}, {"text": "VEGF", "start": 85, "end": 89}, {"text": "AP-2 protein", "start": 126, "end": 138}, {"text": "TGF alpha", "start": 168, "end": 177}, {"text": "VPF", "start": 186, "end": 189}, {"text": "VEGF", "start": 190, "end": 194}]}}, "schema": []}
{"input": "Cytohesin-1, a protein abundant in cells of the immune system, has been proposed to be a human homolog of the Saccharomyces cerevisiae Sec7 gene product, which is crucial in protein transport.", "output": {"entities": {"gene": [{"text": "Cytohesin-1", "start": 0, "end": 11}, {"text": "Saccharomyces cerevisiae Sec7 gene product", "start": 110, "end": 152}]}}, "schema": []}
{"input": "In this regard, it differs from a recently reported BFA-sensitive ARF-GEP that contains a Sec7 domain.", "output": {"entities": {"gene": [{"text": "ARF", "start": 66, "end": 69}, {"text": "GEP", "start": 70, "end": 73}, {"text": "Sec7 domain", "start": 90, "end": 101}]}}, "schema": []}
{"input": "The recombinant protein was purified to homogeneity by (NH4) 2SO4-precipitation and affinity chromatography on 5' AMP-Sepharose.", "output": {"entities": {}}, "schema": []}
{"input": "Derepression of gene expression mediated by the 5' upstream region of the isocitrate lyase gene of Candida tropicalis is controlled by two distinct regulatory pathways in Saccharomyces cerevisiae.", "output": {"entities": {"gene": [{"text": "isocitrate lyase gene of Candida tropicalis", "start": 74, "end": 117}]}}, "schema": []}
{"input": "99mTc-HMPAO was distributed in the territories of the ACA and MCA in the two patients who were treated with intraarterial infusion of papaverine from the C4 segment, but was distributed only to the territory of the ACA in four patients who were treated with intraarterial infusion of papaverine from the C1 segment at 1 ml/min.", "output": {"entities": {}}, "schema": []}
{"input": "This brief review analyses these interactions and defines clinical settings where antibiotic-induced endotoxin release may prove to be clinically relevant.", "output": {"entities": {}}, "schema": []}
{"input": "These changes in virus entry features may result in coronaviruses with novel pathogenic properties.", "output": {"entities": {}}, "schema": []}
{"input": "Effect of Azadirachta indica hydroalcoholic leaf extract on the cardiovascular system.", "output": {"entities": {}}, "schema": []}
{"input": "In cellular supernatant fraction, SHRSP showed a decrease of magnesium in many tissues and an elevation of the calcium to magnesium ratio when compared to age-matched WKY and SHRSR.", "output": {"entities": {}}, "schema": []}
{"input": "The reduced NO production in these cells was associated with low levels of mRNA of inducible NO synthetase.", "output": {"entities": {"gene": [{"text": "inducible NO synthetase", "start": 83, "end": 106}]}}, "schema": []}
{"input": "Apart from iron regulation, sodA expression was affected by changes in DNA topology induced by coumermycin A but not by the global virulence regulatory Bvg system.", "output": {"entities": {"gene": [{"text": "sodA", "start": 28, "end": 32}, {"text": "Bvg system", "start": 152, "end": 162}]}}, "schema": []}
{"input": "In the present study, we have isolated and sequenced several p15E cDNA gene fragments amplified by means of polymerase chain reaction (PCR) from parental (P815) and xenogenized (P815/DTIC) tumour cells.", "output": {"entities": {"gene": [{"text": "p15E cDNA gene fragments", "start": 61, "end": 85}]}}, "schema": []}
{"input": "Transcriptional activity was measured by slot-blot hybridization with steady-state RNA isolated from lacZ + M. smegmatis clones.", "output": {"entities": {"gene": [{"text": "lacZ + M. smegmatis", "start": 101, "end": 120}]}}, "schema": []}
{"input": "Movement time and kinematic characteristics were analyzed together with the magnitude of cerebral blood flow to identify areas of brain activity proportionate to task and movement variables.", "output": {"entities": {}}, "schema": []}
{"input": "Areas with significantly greater rCBF for targeting were the left motor cortex, left intraparietal sulcus, and left caudate.", "output": {"entities": {}}, "schema": []}
{"input": "Recent studies have demonstrated that the U1 snRNP is recruited to the 5' splice site by protein/protein interactions involving the SR domains of the U1-70K protein and SF2/ASF.", "output": {"entities": {"gene": [{"text": "U1 snRNP", "start": 42, "end": 50}, {"text": "SR", "start": 132, "end": 134}, {"text": "U1-70K protein", "start": 150, "end": 164}, {"text": "SF2", "start": 169, "end": 172}, {"text": "ASF", "start": 173, "end": 176}]}}, "schema": []}
{"input": "Thus, the tri-snRNP-specific 27K protein could potentially be involved in SR protein-mediated protein/protein interactions and, additionally, its phosphorylation state could modulate pre-mRNA splicing.", "output": {"entities": {"gene": [{"text": "SR", "start": 74, "end": 76}]}}, "schema": []}
{"input": "Although methods to align the control and activation fMR images may correct for some of this motional error, they will be incomplete in correcting for those that depend on spatial orientation.", "output": {"entities": {}}, "schema": []}
{"input": "Three women have had abnormal endocervical follow up cytology suggestive of residual disease.", "output": {"entities": {}}, "schema": []}
{"input": "This site is upstream from the TATA box used in somatic cells.", "output": {"entities": {}}, "schema": []}
{"input": "An aromatic stacking interaction between subunits helps mediate DNA sequence specificity: operator site discrimination by phage lambda cI repressor.", "output": {"entities": {"gene": [{"text": "phage lambda cI repressor", "start": 122, "end": 147}]}}, "schema": []}
{"input": "We have characterized a panel of 6 monoclonal antibodies raised against human platelet talin by Western blotting, immune precipitation, and immunofluorescence, and shown that antibodies TA205 and TD77 disrupt actin stress fibers and focal adhesions, and inhibit cell motility when microinjected into human fibroblasts.", "output": {"entities": {"gene": [{"text": "human platelet talin", "start": 72, "end": 92}, {"text": "antibodies TA205", "start": 175, "end": 191}, {"text": "TD77", "start": 196, "end": 200}, {"text": "actin", "start": 209, "end": 214}]}}, "schema": []}
{"input": "Here we report the purification of this larger form as an approximately 320-kDa particle that contains mRNP3 + 4 and nine additional polypeptides, including mRNA-binding polypeptides of 34 and 36 kDa and a doublet of 110/105 kDa that proved to be nucleolin.", "output": {"entities": {"gene": [{"text": "mRNP3 + 4", "start": 103, "end": 112}, {"text": "nucleolin", "start": 247, "end": 256}]}}, "schema": []}
{"input": "This study indicates that the phenotype of myofibrillar disarray seen in HCM patients which harbor either of these two mutations may not be directly due to the failure of the mutant myosin heavy chain protein to assemble and form normal sarcomeres, but may rather be a secondary effect possibly resulting from the chronic stress of decreased beta MHC function.", "output": {"entities": {"gene": [{"text": "mutant myosin heavy chain protein", "start": 175, "end": 208}, {"text": "beta MHC", "start": 342, "end": 350}]}}, "schema": []}
{"input": "A method for the simultaneous determination of de (N-methyl)-N-ethyl-8, 9-anhydroerythromycin A 6, 9-hemiacetal (EM523, I) and its three metabolites in human plasma and urine has been developed using high-performance liquid chromatography (HPLC) with chemiluminescence (CL) detection.", "output": {"entities": {}}, "schema": []}
{"input": "Cotransfection of Ets-2 and p44 mitogen-activated protein (MAP) kinase expression vectors strongly potentiated HB-EGF promoter activation in response to deltaRaf-1: ER.", "output": {"entities": {"gene": [{"text": "Ets-2", "start": 18, "end": 23}, {"text": "p44 mitogen-activated protein (MAP) kinase", "start": 28, "end": 70}, {"text": "HB", "start": 111, "end": 113}, {"text": "EGF", "start": 114, "end": 117}, {"text": "deltaRaf-1", "start": 153, "end": 163}, {"text": "ER", "start": 165, "end": 167}]}}, "schema": []}
{"input": "The Rlm1 protein, a member of the MADS box family of transcription factors, functions downstream of Mpk1 in the pathway.", "output": {"entities": {"gene": [{"text": "Rlm1 protein", "start": 4, "end": 16}, {"text": "MADS box family", "start": 34, "end": 49}, {"text": "Mpk1", "start": 100, "end": 104}]}}, "schema": []}
{"input": "The likelihood that a common region of deletions would contain a tumor suppressor is strongly enhanced by coincidence of that region with a chromosome fragment suppressing tumorigenicity upon introduction in tumor cells.", "output": {"entities": {}}, "schema": []}
{"input": "The carboxyl-terminal CCCC module is structurally related to the DNA-binding domain of the erythroid transcription factor GATA-1.", "output": {"entities": {"gene": [{"text": "erythroid transcription factor GATA-1", "start": 91, "end": 128}]}}, "schema": []}
{"input": "The different holoenzyme RNA polymerases generated upon reconstituting these mutants independently with core RNA polymerase (alpha2beta beta') have shown reduced transcriptional activity in comparison to the enzyme containing wild-type sigma factor.", "output": {"entities": {"gene": [{"text": "holoenzyme RNA polymerases", "start": 14, "end": 40}, {"text": "core RNA polymerase", "start": 104, "end": 123}, {"text": "alpha2beta beta'", "start": 125, "end": 141}, {"text": "wild-type sigma factor", "start": 226, "end": 248}]}}, "schema": []}
{"input": "These data are consistent with a model in which GATA-5 performs a unique temporally and spatially restricted function in the embryonic heart and lung.", "output": {"entities": {"gene": [{"text": "GATA-5", "start": 48, "end": 54}]}}, "schema": []}
{"input": "The similar phenotypes of bur6 and bur3 (mot1) mutations suggest that Bur6p and Mot1p have related, but not identical, functions in modulating the activity of the general transcription machinery in vivo.", "output": {"entities": {"gene": [{"text": "bur6", "start": 26, "end": 30}, {"text": "bur3", "start": 35, "end": 39}, {"text": "mot1", "start": 41, "end": 45}, {"text": "Bur6p", "start": 70, "end": 75}, {"text": "Mot1p", "start": 80, "end": 85}]}}, "schema": []}
{"input": "A genetic screen applied to mutants in the branch site region shows that all positions in the conserved TACTAAC sequence are important for intron recognition.", "output": {"entities": {}}, "schema": []}
{"input": "Implication of PAF and acetylhydrolase (PAF-AH) activity in periodontal disease.", "output": {"entities": {"gene": [{"text": "PAF", "start": 15, "end": 18}, {"text": "acetylhydrolase", "start": 23, "end": 38}, {"text": "PAF-AH", "start": 40, "end": 46}]}}, "schema": []}
{"input": "A polypeptide encoded by the NTS 16 open reading frame has sequence similarity to the catalytic domain of several receptor protein kinases from plants including the S-receptor kinases implicated in the rejection of self-pollen in Brassica species and the Pto gene product of tomato which confers resistance to a bacterial pathogen.", "output": {"entities": {"gene": [{"text": "receptor protein kinases from plants", "start": 114, "end": 150}, {"text": "S-receptor kinases", "start": 165, "end": 183}, {"text": "Pto gene product of tomato", "start": 255, "end": 281}]}}, "schema": []}
{"input": "The atp 1 and atp 2 types of cDNA sequences were the most redundant among the 28 different isoperoxidases identified among about 200 peroxidase encoding ESTs.", "output": {"entities": {"gene": [{"text": "atp 1", "start": 4, "end": 9}, {"text": "atp 2", "start": 14, "end": 19}, {"text": "isoperoxidases", "start": 91, "end": 105}, {"text": "peroxidase encoding ESTs", "start": 133, "end": 157}]}}, "schema": []}
{"input": "Glycemic response to malted, popped and roller dried wheat-legume based foods in normal subjects.", "output": {"entities": {}}, "schema": []}
{"input": "4. 26 +/-1. 54 mmol/l, P < 0. 01), and systolic BP responses to intravenous norepinephrine and angiotensin II were significantly higher on glibenclamide than on metformin (P < 0. 02 and P < 0. 05, respectively).", "output": {"entities": {"gene": [{"text": "angiotensin II", "start": 95, "end": 109}]}}, "schema": []}
{"input": "Is leishmaniasis endemic on the island of Minorca (Spain)? A human visceral case after living 13 years in Minorca.", "output": {"entities": {}}, "schema": []}
{"input": "RESULTS: Surprisingly, PAF blockade increased mortality after trauma (5 of 11 WEB-2086 animals versus 1 of 9 vehicle animals; p = 0. 15) and depressed cardiac index and O2 delivery at 72 hours (p < 0. 05).", "output": {"entities": {"gene": [{"text": "PAF", "start": 23, "end": 26}]}}, "schema": []}
{"input": "This finding is the first example of utilization of noncomplementary dinucleotide primer by an RNA polymerase.", "output": {"entities": {"gene": [{"text": "RNA polymerase", "start": 95, "end": 109}]}}, "schema": []}
{"input": "Pure T1 and dual-T1 images were visually evaluated for image quality (IQ) on a five-point scale (0 = unacceptable to 4 = excellent).", "output": {"entities": {}}, "schema": []}
{"input": "This conformer features a Type I beta-turn and has extensive hydrophobic contacts with the FKBP12 binding surface.", "output": {"entities": {"gene": [{"text": "FKBP12", "start": 91, "end": 97}]}}, "schema": []}
{"input": "Children' s temperament and maternal socialization at Time 1 (n = 103, aged 2-3 years) were considered predictors of future conscience, assessed using new observational and narrative measures.", "output": {"entities": {}}, "schema": []}
{"input": "One P1 genomic clone and six subsequent plasmid subclones were isolated and analyzed for the exon-intron organization of the Ctpct gene.", "output": {"entities": {"gene": [{"text": "Ctpct gene", "start": 125, "end": 135}]}}, "schema": []}
{"input": "Congruent with empirical predictions, the most homesick children perceived low control over homesickness and separation, and coped by relinquishing control.", "output": {"entities": {}}, "schema": []}
{"input": "We also review the role of grains in the formation of complex molecules in interstellar molecular clouds.", "output": {"entities": {}}, "schema": []}
{"input": "The C-LIP also was compared with transcather arterial embolization (TAE; C-LIP followed by gelatin sponge) and percutaneous ethanol injection therapy (PEIT).", "output": {"entities": {}}, "schema": []}
{"input": "We also demonstrate that preformed triplexes are quite stable when precipitated with ethanol and resuspended in water.", "output": {"entities": {}}, "schema": []}
{"input": "Transfection experiments using preformed triplexes with a reporter plasmid containing the collagen promoter sequence showed significant inhibition of transcription when compared with a control phosphorothioate ODN.", "output": {"entities": {"gene": [{"text": "collagen promoter sequence", "start": 90, "end": 116}]}}, "schema": []}
{"input": "Thus, an increase in plasma TBG and a shift from adrenal androgen and mineralocorticoid steroid secretion towards cortisol secretion may be endocrine markers for progression of the disease in patients with HIV-infection.", "output": {"entities": {"gene": [{"text": "plasma TBG", "start": 21, "end": 31}]}}, "schema": []}
{"input": "Latanoprost produces an additional reduction of intraocular pressure (IOP) when used in combination with timolol, pilocarpine, acetazolamide and dipivefrin.", "output": {"entities": {}}, "schema": []}
{"input": "Transient overexpression of c-Jun induced tenascin-C expression in primary REF and in FR3T3, an established fibroblast cell line.", "output": {"entities": {"gene": [{"text": "c-Jun", "start": 28, "end": 33}, {"text": "tenascin-C", "start": 42, "end": 52}]}}, "schema": []}
{"input": "Selected parameters: heart rate (HR), arterial blood pressure (ABP) and arterial O2 saturation (SaO2) monitored by pulsoximetry were measured during the procedure.", "output": {"entities": {}}, "schema": []}
{"input": "We have tested this proposal by carrying out circular dichroism (CD) and NMR experiments on the Skn domain and five truncated proteins.", "output": {"entities": {"gene": [{"text": "Skn domain", "start": 96, "end": 106}]}}, "schema": []}
{"input": "Genes for ocs element binding factors (OBFs), belonging to a specific class of basic-region leucine zipper (bZIP) transcription factors, have been isolated in a number of plants.", "output": {"entities": {"gene": [{"text": "ocs element binding factors", "start": 10, "end": 37}, {"text": "OBFs", "start": 39, "end": 43}, {"text": "basic-region leucine zipper (bZIP) transcription factors", "start": 79, "end": 135}]}}, "schema": []}
{"input": "SRE activity is dependent upon the activation by phosphorylation of a ternary complex factor; included among the ternary complex factors is Elk-1.", "output": {"entities": {"gene": [{"text": "Elk-1", "start": 140, "end": 145}]}}, "schema": []}
{"input": "A xylE transcriptional fusion to the putative mxbD promoter showed low-level expression in wild-type cells grown on one-carbon (C1) compounds and no detectable expression in cells grown on succinate.", "output": {"entities": {"gene": [{"text": "xylE transcriptional fusion", "start": 2, "end": 29}, {"text": "mxbD promoter", "start": 46, "end": 59}]}}, "schema": []}
{"input": "Pax-3 is a paired-type homeobox gene that is specifically expressed in the dorsal and posterior neural tube.", "output": {"entities": {"gene": [{"text": "Pax-3", "start": 0, "end": 5}, {"text": "paired-type homeobox gene", "start": 11, "end": 36}]}}, "schema": []}
{"input": "Instead, they contained dendritic cells that express melanogenic marker proteins such as tyrosinase and tyrosinase-related protein 1.", "output": {"entities": {"gene": [{"text": "tyrosinase", "start": 89, "end": 99}, {"text": "tyrosinase-related protein 1", "start": 104, "end": 132}]}}, "schema": []}
{"input": "These mutations create stop codons in exon 7 and 8, respectively, and probably result in truncated proteins lacking HLH-Zip or Zip structure.", "output": {"entities": {}}, "schema": []}
{"input": "These six amino acids are part of an amphipathic helix that is highly conserved among nuclear hormone receptors and contains the core domain of the ligand-dependent transactivation function, AF-2.", "output": {"entities": {"gene": [{"text": "nuclear hormone receptors", "start": 86, "end": 111}]}}, "schema": []}
{"input": "Surprisingly, the RXR-specific ligand 9-cis-retinoic acid induced binding of SRC-1 to the RXR component of the TRE-bound heterodimer.", "output": {"entities": {"gene": [{"text": "RXR", "start": 18, "end": 21}, {"text": "SRC-1", "start": 77, "end": 82}, {"text": "RXR component", "start": 90, "end": 103}]}}, "schema": []}
{"input": "Using PRL-R tagged both in the N-terminal or C-terminal regions of the mature receptor excludes the possibility of a cleaved fragment which could have been subsequently imported into the nucleus.", "output": {"entities": {"gene": [{"text": "PRL-R", "start": 6, "end": 11}]}}, "schema": []}
{"input": "Transcription of these genes was also elevated in gut and lung during freezing, but mRNA levels in these tissues were lower than in liver.", "output": {"entities": {}}, "schema": []}
{"input": "The most important one among them is Cyclosporin A, which is a selective immunosuppressive drug.", "output": {"entities": {}}, "schema": []}
{"input": "Using a conditional-lethal mutant allele of SUP45 (sup45-2) and a combination of in vivo and in vitro approaches, we demonstrate that the product of the SUP45 gene (Sup45p or eRF1) is a factor required for translation termination in yeast.", "output": {"entities": {"gene": [{"text": "SUP45", "start": 44, "end": 49}, {"text": "sup45-2", "start": 51, "end": 58}, {"text": "SUP45 gene", "start": 153, "end": 163}, {"text": "Sup45p", "start": 165, "end": 171}, {"text": "eRF1", "start": 175, "end": 179}]}}, "schema": []}
{"input": "She was able to stand unaided by 3 years of age with then progressive worsening of motor abilities.", "output": {"entities": {}}, "schema": []}
{"input": "Merosin positive congenital muscular dystrophy with mental deficiency, epilepsy and MRI changes in the cerebral white matter.", "output": {"entities": {"gene": [{"text": "Merosin", "start": 0, "end": 7}]}}, "schema": []}
{"input": "Also, transient overexpression of this protein in C2C12 cells reduced the transcription of a CAT-reporter regulated by an E12/MyoD driven enhancer.", "output": {"entities": {"gene": [{"text": "CAT", "start": 93, "end": 96}, {"text": "E12", "start": 122, "end": 125}, {"text": "MyoD", "start": 126, "end": 130}]}}, "schema": []}
{"input": "Type I position-vestibular-pause (PVP I) and vestibular-only (V I) neurons, as well as a smaller number of other type I and type II eye-plus-vestibular neurons were studied.", "output": {"entities": {}}, "schema": []}
{"input": "Using mouse-human somatic hybrids and FISH analysis, the PE-2 gene is localized to human chromosome 19q13. 2, a region involved in translocations and deletions in leukemias and several solid tumors, suggesting that this novel ETS factor may play a role in carcinogenesis.", "output": {"entities": {"gene": [{"text": "PE-2 gene", "start": 57, "end": 66}, {"text": "ETS factor", "start": 226, "end": 236}]}}, "schema": []}
{"input": "Sequence divergence is observed in untranslated regions which allows the definition of gene-specific probes.", "output": {"entities": {}}, "schema": []}
{"input": "In adherent macrophages, absence of CD45 led to the hyperphosphorylation and hyperactivation of p56/59 (hck) and p53/56 (lyn), but not of p58 (c-fgr).", "output": {"entities": {"gene": [{"text": "CD45", "start": 36, "end": 40}, {"text": "p56/59", "start": 96, "end": 102}, {"text": "hck", "start": 104, "end": 107}, {"text": "p53/56", "start": 113, "end": 119}, {"text": "lyn", "start": 121, "end": 124}, {"text": "p58", "start": 138, "end": 141}, {"text": "c-fgr", "start": 143, "end": 148}]}}, "schema": []}
{"input": "Secretion in milk and transplacental transfer of two iodized oils, Lipiodol UF and Oriodol, in rabbits.", "output": {"entities": {}}, "schema": []}
{"input": "The RNA-binding and RNA-DNA helicase activities of the Escherichia coli transcription termination factor rho have been investigated using natural RNA molecules that are 255 and 391 nucleotide residues in length and that contain the trp t' rho-dependent termination sequence of E. coli.", "output": {"entities": {"gene": [{"text": "RNA-DNA helicase", "start": 20, "end": 36}, {"text": "Escherichia coli transcription termination factor rho", "start": 55, "end": 108}, {"text": "trp t' rho-dependent termination sequence", "start": 232, "end": 273}]}}, "schema": []}
{"input": "The serum levels of beta-human chorionic gonadotropin (HCG) and placental alkaline phosphatase (PLAP) were not elevated.", "output": {"entities": {"gene": [{"text": "beta-human chorionic gonadotropin", "start": 20, "end": 53}, {"text": "HCG", "start": 55, "end": 58}, {"text": "placental alkaline phosphatase", "start": 64, "end": 94}, {"text": "PLAP", "start": 96, "end": 100}]}}, "schema": []}
{"input": "Thus E14. 1TG3B1 is a useful ES cell line for modifying the mouse genome using the HPRT gene as a selection marker and for transmission at a high frequency into the mouse germ line.", "output": {"entities": {"gene": [{"text": "HPRT gene", "start": 83, "end": 92}]}}, "schema": []}
{"input": "OBJECTIVE: This study was designed to analyze the common cause of asthenopia, mixed astigmatism.", "output": {"entities": {}}, "schema": []}
{"input": "One RNA construct which consisted of 112 nucleotides (nt) from nt 639 to nt 750 formed a heterodimeric complex with the RNA which consisted of 200 nucleotides from nt 551 to nt 750.", "output": {"entities": {}}, "schema": []}
{"input": "However, we could not find the homologous regions with guanine nucleotide exchange factors or GTPase-activating proteins in the c-cbl gene.", "output": {"entities": {"gene": [{"text": "guanine nucleotide exchange factors", "start": 55, "end": 90}, {"text": "GTPase-activating proteins", "start": 94, "end": 120}, {"text": "c-cbl gene", "start": 128, "end": 138}]}}, "schema": []}
{"input": "Aryl hydrocarbon receptor nuclear translocator (ARNT) is a component of the transcription factors, aryl hydrocarbon receptor (AhR) and hypoxia-inducible factor 1, which transactivate their target genes, such as CYP1A1 and erythropoietin, in response to xenobiotic aromatic hydrocarbons and to low O2 concentration, respectively.", "output": {"entities": {"gene": [{"text": "Aryl hydrocarbon receptor nuclear translocator", "start": 0, "end": 46}, {"text": "ARNT", "start": 48, "end": 52}, {"text": "aryl hydrocarbon receptor", "start": 99, "end": 124}, {"text": "AhR", "start": 126, "end": 129}, {"text": "hypoxia-inducible factor 1", "start": 135, "end": 161}, {"text": "CYP1A1", "start": 211, "end": 217}, {"text": "erythropoietin", "start": 222, "end": 236}]}}, "schema": []}
{"input": "We also provide evidence that gar2 is phosphorylated in vitro by a p13 (suc1)-Sepharose-bound kinase from Schizosaccharomyces pombe extracts that displays cell cycle-regulated activity similar to that of the p34 (cdc2 (kinase.", "output": {"entities": {"gene": [{"text": "gar2", "start": 30, "end": 34}, {"text": "p13", "start": 67, "end": 70}, {"text": "suc1", "start": 72, "end": 76}, {"text": "p34", "start": 208, "end": 211}, {"text": "cdc2", "start": 213, "end": 217}]}}, "schema": []}
{"input": "However, by immobilized metal affinity chromatography assay, self-association of PR-A was 3. 5-fold more efficient than that of either the DhLBD or hLBD constructs.", "output": {"entities": {"gene": [{"text": "PR-A", "start": 81, "end": 85}]}}, "schema": []}
{"input": "The overall results of this paper are consistent with the conclusion that the carboxyl-terminal LBD is not sufficient for mediating PR dimerization and that multiple regions, including the hinge and amino-terminal sequences, contribute either directly or indirectly to homodimerization of PR.", "output": {"entities": {"gene": [{"text": "PR", "start": 132, "end": 134}, {"text": "PR", "start": 289, "end": 291}]}}, "schema": []}
{"input": "Colorectal carcinoma: therapeutic approach in patients already treated with metastasis resection", "output": {"entities": {}}, "schema": []}
{"input": "Alternative splicing of ClC-6 (a member of the CIC chloride-channel family) transcripts generates three truncated isoforms one of which, ClC-6c, is kidney-specific.", "output": {"entities": {"gene": [{"text": "ClC-6", "start": 24, "end": 29}, {"text": "CIC chloride-channel family", "start": 47, "end": 74}, {"text": "ClC-6c", "start": 137, "end": 143}]}}, "schema": []}
{"input": "The frequency of positive anti-GM1 antibody titers in the Guillain-Barre syndrome patients with PEN 19 isolates was higher than that in the Guillain-Barre syndrome and Fisher' s syndrome patients without PEN 19 isolates.", "output": {"entities": {"gene": [{"text": "anti-GM1 antibody", "start": 26, "end": 43}]}}, "schema": []}
{"input": "NF-kappa B/Rel transcription factors participate in the activation of numerous genes involved in immune regulation/inflammation including cytokines, cell surface receptors, adhesion molecules, and acute phase proteins.", "output": {"entities": {"gene": [{"text": "NF-kappa B", "start": 0, "end": 10}, {"text": "Rel", "start": 11, "end": 14}]}}, "schema": []}
{"input": "However, mean food intake in the 40% group was half that of the ACT group (p < 0. 001) and significantly less (p < 0. 01) than the SEP group, which consumed amounts equivalent to 65% of daily requirement.", "output": {"entities": {}}, "schema": []}
{"input": "We have separated a dermatan sulfate proteoglycan, epiphycan, from decorin and biglycan by using dissociative extraction of bovine fetal epiphyseal cartilage, followed by sequential ion-exchange, gel permeation, hydrophobic, and Zn2 + chelate chromatographic steps.", "output": {"entities": {"gene": [{"text": "decorin", "start": 67, "end": 74}]}}, "schema": []}
{"input": "The mean times to detection of all mycobacteria with BACTEC 9000 MB and BACTEC 460 TB were similar (10. 3 and 10. 0 days, respectively).", "output": {"entities": {}}, "schema": []}
{"input": "Though the BACTEC 9000 MB system is recommended for respiratory specimens, we demonstrated that it can be successfully used also for recovery of mycobacteria from clinical specimens from various extrapulmonary sites.", "output": {"entities": {}}, "schema": []}
{"input": "A pre-boutonniere deformity was simulated by dividing the central slip.", "output": {"entities": {}}, "schema": []}
{"input": "This regulation requires two HMG-box proteins: the ubiquitous Ste11 transcription factor and the M cell-controlling protein Mat1-Mc.", "output": {"entities": {"gene": [{"text": "HMG-box proteins", "start": 29, "end": 45}, {"text": "Ste11 transcription factor", "start": 62, "end": 88}, {"text": "Mat1-Mc", "start": 124, "end": 131}]}}, "schema": []}
{"input": "Neither of these proteins, individually or as a pair, can bind the alpha-globin 3' UTR unless they are complexed with the remaining non-poly (C) binding proteins of the alpha-complex.", "output": {"entities": {"gene": [{"text": "alpha-globin 3' UTR", "start": 67, "end": 86}, {"text": "alpha-complex", "start": 169, "end": 182}]}}, "schema": []}
{"input": "(1996a) Biochemistry 35, 1589-1598].", "output": {"entities": {}}, "schema": []}
{"input": "A prospective observational study was conducted to identify early indicators of acute dengue virus infection.", "output": {"entities": {}}, "schema": []}
{"input": "It is present in the nucleus of the cells in which it is expressed and can phosphorylate and activate the cyclic AMP response element binding proteins CREB and CREM tau in a manner analogous to protein kinase A.", "output": {"entities": {"gene": [{"text": "cyclic AMP response element binding proteins CREB", "start": 106, "end": 155}, {"text": "CREM tau", "start": 160, "end": 168}, {"text": "protein kinase A", "start": 194, "end": 210}]}}, "schema": []}
{"input": "These cells fail to generate the signals to phosphorylate CREB and produce significantly less of the cytokine Interleukin-2 (IL-2) in response to agents that either increase intracellular Ca2 + and/or activate protein kinase C.", "output": {"entities": {"gene": [{"text": "CREB", "start": 58, "end": 62}, {"text": "Interleukin-2", "start": 110, "end": 123}, {"text": "IL-2", "start": 125, "end": 129}, {"text": "protein kinase C", "start": 210, "end": 226}]}}, "schema": []}
{"input": "Both of these dogs had low serum IgG (3. 5 to 7. 2 mg/ml) and the second littermate also had reduced serum IgA (< 0. 1 to 0. 15 mg/ml).", "output": {"entities": {"gene": [{"text": "IgG", "start": 33, "end": 36}, {"text": "IgA", "start": 107, "end": 110}]}}, "schema": []}
{"input": "CONCLUSIONS: Valproate appears to inhibit the glucuronidation of carbamazepine-10, 11-trans-diol, and probably also inhibits the conversion of carbamazepine-10, 11-epoxide to this trans-diol derivative, rather than simply inhibiting the latter reaction only.", "output": {"entities": {}}, "schema": []}
{"input": "Proteinuria in a young man.", "output": {"entities": {}}, "schema": []}
{"input": "Neural blockade in chronic and cancer pain.", "output": {"entities": {}}, "schema": []}
{"input": "Five cell strains of human dermal fibroblasts were each treated with three samples of burn blister fluid and the effect compared with the rate of contraction of free floating fibroblast populated collagen lattices (FPCL).", "output": {"entities": {"gene": [{"text": "collagen", "start": 196, "end": 204}]}}, "schema": []}
{"input": "It is thus one of the key enzymes involved in the triiodothyronine-mediated control of growth, differentiation and basal metabolism in vertebrates.", "output": {"entities": {}}, "schema": []}
{"input": "We had previously analyzed repair rates of cyclobutane pyrimidine dimers at nucleotide resolution along the human JUN gene in normal fibroblasts and found very efficient repair of sequences near the transcription initiation site but slow repair along the promoter.", "output": {"entities": {"gene": [{"text": "human JUN gene", "start": 108, "end": 122}]}}, "schema": []}
{"input": "The used expression system could allow to produce mutated forms of SsEF-2 obtained by mutagenesis of the corresponding gene.", "output": {"entities": {"gene": [{"text": "SsEF-2", "start": 67, "end": 73}]}}, "schema": []}
{"input": "Crosstalk among the pathways may explain how some forms of stress can contribute to the development of a malignancy.", "output": {"entities": {}}, "schema": []}
{"input": "MEASUREMENTS AND MAIN RESULTS: Lung elastance (EL) and resistance (RL) were calculated from measurements of airway pressure, esophageal pressure, and airway flow in five anesthetized, paralyzed dogs during sinusoidal forcing at a constant mean airway pressure of 10 cmH2O in a wide range of breathing frequencies (0. 2 to 1. 0 Hz in intervals of 0. 2) and tidal volumes (50, 100, 200, and to 300 mL).", "output": {"entities": {}}, "schema": []}
{"input": "Because the biosynthetic pathway to the vacuole intersects with the endocytic pathway, internalization of a bulk membrane endocytic marker FM 4-64 was assayed in the sop mutants.", "output": {"entities": {"gene": [{"text": "sop mutants", "start": 166, "end": 177}]}}, "schema": []}
{"input": "Naltrexone has been recently approved by the Food and Drug Administration for the treatment of alcohol dependence.", "output": {"entities": {}}, "schema": []}
{"input": "Consistent with this model, a synthetic construct containing three tandem copies of the native LDL receptor SREBP site linked to a single Sp1 site was also significantly activated in a buttonhead-independent fashion.", "output": {"entities": {"gene": [{"text": "LDL receptor SREBP", "start": 95, "end": 113}, {"text": "Sp1 site", "start": 138, "end": 146}, {"text": "buttonhead", "start": 185, "end": 195}]}}, "schema": []}
{"input": "Analysis of the 5' flanking region of the gene also revealed the presence of multiple TATA and CAAT sequences.", "output": {"entities": {}}, "schema": []}
{"input": "Analysis of the 5' flanking region of the gene also revealed the presence of multiple TATA and CAAT sequences.", "output": {"entities": {}}, "schema": []}
{"input": "The m7GpppN cap structure of eukaryotic mRNA is formed cotranscriptionally by the sequential action of three enzymes: RNA triphosphatase, RNA guanylyltransferase, and RNA (guanine-7)-methyltransferase.", "output": {"entities": {"gene": [{"text": "RNA triphosphatase", "start": 118, "end": 136}, {"text": "RNA guanylyltransferase", "start": 138, "end": 161}, {"text": "RNA (guanine-7)-methyltransferase", "start": 167, "end": 200}]}}, "schema": []}
{"input": "CONCLUSION: Patients wit clinically palpable neck disease (N1-3), histological evidence of metastatic nodal disease, extracapsular spread, and three or more positive lymph nodes are at greater risk of developing failure at distant sites.", "output": {"entities": {}}, "schema": []}
{"input": "4.", "output": {"entities": {}}, "schema": []}
{"input": "Area under the drug concentration-time curves (AUC0-24 hr) for MTX were 2379 and 3534 ng * hr/ml from PG-2. 5% Azone and PG-7. 5% Azone systems respectively.", "output": {"entities": {}}, "schema": []}
{"input": "There were differences between males (p < 0. 05) for most of the characteristics studied.", "output": {"entities": {}}, "schema": []}
{"input": "Although previous data have suggested that Rev uses the same export pathway as uracil-rich small nuclear RNAs and 5S ribosomal RNA, the CTE seems to interact with evolutionarily conserved factors that are essential for cellular mRNA export.", "output": {"entities": {"gene": [{"text": "Rev", "start": 43, "end": 46}, {"text": "5S ribosomal RNA", "start": 114, "end": 130}]}}, "schema": []}
{"input": "S2F, a leaf-specific trans-acting factor, binds to a novel cis-acting element and differentially activates the RPL21 gene.", "output": {"entities": {"gene": [{"text": "S2F", "start": 0, "end": 3}, {"text": "RPL21 gene", "start": 111, "end": 121}]}}, "schema": []}
{"input": "Polarised expression of human intestinal N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase (human meprin) alpha and beta subunits in Madin-Darby canine kidney cells.", "output": {"entities": {"gene": [{"text": "N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase", "start": 41, "end": 90}, {"text": "human meprin", "start": 92, "end": 104}]}}, "schema": []}
{"input": "Neither mutant exhibited derepression of the silent mating type loci.", "output": {"entities": {"gene": [{"text": "silent mating type loci", "start": 45, "end": 68}]}}, "schema": []}
{"input": "In contrast to the wild-type protein, expression of p45 NF-E2 lacking this activation domain in an NF-E2 null cell line fails to support enhancer-dependent transcription in transient assays.", "output": {"entities": {"gene": [{"text": "p45 NF-E2", "start": 52, "end": 61}, {"text": "NF-E2", "start": 99, "end": 104}]}}, "schema": []}
{"input": "These findings suggest one potential mechanism for direct recruitment of distal regulatory regions of the globin loci to the individual promoters.", "output": {"entities": {"gene": [{"text": "globin loci", "start": 106, "end": 117}]}}, "schema": []}
{"input": "The promoter region showed no consensus TATA box but it contains CCAAT and CreA boxes known to be involved in both stress and carbon-catabolite regulation of fungal promoters.", "output": {"entities": {"gene": [{"text": "CreA", "start": 75, "end": 79}]}}, "schema": []}
{"input": "In support of this interpretation we demonstrate that MQ9b binds strongly 5 of 17 motif-positive, pathogen-derived synthetic peptides.", "output": {"entities": {"gene": [{"text": "MQ9b", "start": 54, "end": 58}]}}, "schema": []}
{"input": "These discoloration' s can be treated in several ways but up to lately tooth structure had to be removed in an irreversible manner in order to provide sufficient bulk for the new restorative material.", "output": {"entities": {}}, "schema": []}
{"input": "Overexpression of BAG-1 also protected certain cell lines from heat shock-induced cell death.", "output": {"entities": {"gene": [{"text": "BAG-1", "start": 18, "end": 23}]}}, "schema": []}
{"input": "The 5' flanking region contains potential binding sites for TATA-binding protein, Sp1, nuclear factor 1 (NF1), CAAT-box binding protein (C/EBP), hepatocyte nuclear factors 1 and 5 (HNF1, HNF5) and activator proteins 1 and 2 (AP1, AP2).", "output": {"entities": {"gene": [{"text": "TATA-binding protein", "start": 60, "end": 80}, {"text": "Sp1", "start": 82, "end": 85}, {"text": "nuclear factor 1", "start": 87, "end": 103}, {"text": "NF1", "start": 105, "end": 108}, {"text": "CAAT-box binding protein", "start": 111, "end": 135}, {"text": "C/EBP", "start": 137, "end": 142}, {"text": "hepatocyte nuclear factors 1 and 5", "start": 145, "end": 179}, {"text": "HNF1", "start": 181, "end": 185}, {"text": "HNF5", "start": 187, "end": 191}, {"text": "activator proteins 1 and 2", "start": 197, "end": 223}, {"text": "AP1", "start": 225, "end": 228}, {"text": "AP2", "start": 230, "end": 233}]}}, "schema": []}
{"input": "The recognition specificity of the p55 PDZ domain appears to be unique, since the three PDZ domains of hDlg (human lymphocyte homologue of the Drosophila discs large tumor suppressor) do not bind the cytoplasmic domain of glycophorin C.", "output": {"entities": {"gene": [{"text": "p55 PDZ domain", "start": 35, "end": 49}, {"text": "PDZ domains", "start": 88, "end": 99}, {"text": "hDlg", "start": 103, "end": 107}, {"text": "Drosophila discs large tumor suppressor", "start": 143, "end": 182}, {"text": "glycophorin C", "start": 222, "end": 235}]}}, "schema": []}
{"input": "In the United States high-MW HES 480 which is difficult to degrade is most frequently used and results in a larger in vivo MW and subsequent decrease in factor VIII/von Willebrand factor levels.", "output": {"entities": {"gene": [{"text": "factor VIII", "start": 153, "end": 164}, {"text": "von Willebrand factor", "start": 165, "end": 186}]}}, "schema": []}
{"input": "In our previous studies, transcriptional activation was shown to correlate with IEP86 binding to both the TATA-box binding protein (TBP) and the transcription factor bound upstream.", "output": {"entities": {"gene": [{"text": "IEP86", "start": 80, "end": 85}, {"text": "TATA-box binding protein", "start": 106, "end": 130}, {"text": "TBP", "start": 132, "end": 135}]}}, "schema": []}
{"input": "Previously, we reported that scanthrough translation, where the initiating AUG of a primary open reading frame is bypassed, is most likely to account for the presentation of cryptic epitopes from alternative reading frames within the influenza A PR/8/34 nucleoprotein gene.", "output": {"entities": {"gene": [{"text": "influenza A PR/8/34 nucleoprotein gene", "start": 234, "end": 272}]}}, "schema": []}
{"input": "The deduced amino acid sequence of the gene has significant homology to the interferon regulatory factors (IRFs).", "output": {"entities": {"gene": [{"text": "interferon regulatory factors", "start": 76, "end": 105}, {"text": "IRFs", "start": 107, "end": 111}]}}, "schema": []}
{"input": "The pheromone response pathway activates transcription of Ty5 retrotransposons located within silent chromatin of Saccharomyces cerevisiae.", "output": {"entities": {"gene": [{"text": "Ty5 retrotransposons", "start": 58, "end": 78}]}}, "schema": []}
{"input": "The malate synthase gene, MLS1, of the yeast Saccharomyces cerevisiae is transcriptionally regulated by the carbon source in the growth medium.", "output": {"entities": {"gene": [{"text": "malate synthase gene", "start": 4, "end": 24}, {"text": "MLS1", "start": 26, "end": 30}]}}, "schema": []}
{"input": "By deletion analysis of the MLS1 control region, we identified two sites, UAS1 and UAS2, as important for efficient derepression of the gene.", "output": {"entities": {"gene": [{"text": "MLS1", "start": 28, "end": 32}]}}, "schema": []}
{"input": "Prior to meals 2 to 3 times daily, 1-2 tablespoons of Alzoon are recommended.", "output": {"entities": {}}, "schema": []}
{"input": "These results suggest that UBP41 may play an important role in the recycling of ubiquitin by hydrolysis of branched poly-ubiquitin chains generated by the action of 26 S proteasome on poly-ubiquitinated protein substrates, as well as in the production of free ubiquitin from linear poly-ubiquitin chains and of certain ribosomal proteins from ubiquitin fusion proteins.", "output": {"entities": {"gene": [{"text": "UBP41", "start": 27, "end": 32}, {"text": "ubiquitin", "start": 80, "end": 89}, {"text": "branched poly-ubiquitin chains", "start": 107, "end": 137}, {"text": "26 S proteasome", "start": 165, "end": 180}, {"text": "ubiquitinated", "start": 189, "end": 202}, {"text": "linear poly-ubiquitin chains", "start": 275, "end": 303}, {"text": "ubiquitin fusion proteins", "start": 343, "end": 368}]}}, "schema": []}
{"input": "The regurgitation of large vitreous injections.", "output": {"entities": {}}, "schema": []}
{"input": "Attenuation from the vit A2 consensus ERE is not necessarily dependent on DNA binding as the TR alpha DNA binding mutant was still able to inhibit E-dependent transactivation.", "output": {"entities": {"gene": [{"text": "vit A2", "start": 21, "end": 27}, {"text": "TR alpha", "start": 93, "end": 101}]}}, "schema": []}
{"input": "Null mutations in daf-3 suppress mutations in genes encoding this TGF-beta signal, its receptors, and associated Smad signal transduction proteins. daf-3 encodes a Smad protein that is most closely related to mammalian DPC4, and is expressed throughout development in many of the tissues that are remodeled during dauer development.", "output": {"entities": {"gene": [{"text": "daf-3", "start": 18, "end": 23}, {"text": "TGF-beta", "start": 66, "end": 74}, {"text": "Smad signal transduction proteins", "start": 113, "end": 146}, {"text": "daf-3", "start": 148, "end": 153}, {"text": "Smad protein", "start": 164, "end": 176}, {"text": "mammalian DPC4", "start": 209, "end": 223}]}}, "schema": []}
{"input": "We have overexpressed, purified, characterized, and crystallized the BTB/POZ domain from PLZF (PLZF-BTB/POZ).", "output": {"entities": {"gene": [{"text": "BTB", "start": 69, "end": 72}, {"text": "PLZF", "start": 89, "end": 93}, {"text": "PLZF", "start": 95, "end": 99}, {"text": "BTB", "start": 100, "end": 103}]}}, "schema": []}
{"input": "Furthermore, deletion and mutation analyses of the VCAM-1 promoter performed with chloramphenicol acetyltransferase constructs revealed that Tax was trans activating the VCAM-1 promoter via two NF-kappaB sites present at bp-72 and-57 in the VCAM-1 gene promoter, with both of them being required for the Tax-induced expression of this adhesion molecule.", "output": {"entities": {"gene": [{"text": "VCAM-1 promoter", "start": 51, "end": 66}, {"text": "chloramphenicol acetyltransferase constructs", "start": 82, "end": 126}, {"text": "Tax", "start": 141, "end": 144}, {"text": "VCAM-1 promoter", "start": 170, "end": 185}, {"text": "NF-kappaB sites", "start": 194, "end": 209}, {"text": "VCAM-1 gene promoter", "start": 241, "end": 261}, {"text": "Tax", "start": 304, "end": 307}]}}, "schema": []}
{"input": "The AGM and NIH/Swiss mouse CCR5 proteins are 97. 7 to 98. 3% and 79. 8% identical to the human protein, respectively.", "output": {"entities": {"gene": [{"text": "AGM and NIH/Swiss mouse CCR5 proteins", "start": 4, "end": 41}]}}, "schema": []}
{"input": "Recently, roles also have been suggested for the nuclear trans-factor GATA-1 in regulating progenitor cell proliferation.", "output": {"entities": {"gene": [{"text": "GATA-1", "start": 70, "end": 76}]}}, "schema": []}
{"input": "(ii) An AF G-CSF level > 2000 pg/ml is a strong positive predictor of CAM.", "output": {"entities": {"gene": [{"text": "G-CSF", "start": 11, "end": 16}]}}, "schema": []}
{"input": "[Pulmonary vascular resistance (PVR) during 10% O2-PVR during 21% O2/PVR during 21% O2] x 100 was termed as hypoxic pulmonary vasoconstriction (HPV).", "output": {"entities": {}}, "schema": []}
{"input": "An unusual cysteine triplet conserved in the sequences of TB domains is localized to the hydrophobic core, at the C-terminus of an alpha-helix.", "output": {"entities": {"gene": [{"text": "TB domains", "start": 58, "end": 68}]}}, "schema": []}
{"input": "Protein phosphatases play a critical role in the regulation of the eukaryotic cell cycle and signal transduction.", "output": {"entities": {}}, "schema": []}
{"input": "Re: \" Assessing the direction of causality in cross-sectional studies \".", "output": {"entities": {}}, "schema": []}
{"input": "Restriction enzyme mapping, subcloning, and DNA sequencing analysis of recombinant phage lambda and P1 clones revealed that exons encoding the 1. 9-kb mouse TS mRNA are dispersed over > 150 kb genomic DNA.", "output": {"entities": {"gene": [{"text": "mouse TS mRNA", "start": 151, "end": 164}]}}, "schema": []}
{"input": "Transfection analyses indicated that the expression of Tbxas1 is controlled by a short (70-bp) positive regulatory sequence and several upstream repressive elements.", "output": {"entities": {"gene": [{"text": "Tbxas1", "start": 55, "end": 61}]}}, "schema": []}
{"input": "Electromobility shift and cotransfection assays demonstrated that HNF1alpha, but not HNF4, bound to its cognate site and transactivated G6Pase gene expression.", "output": {"entities": {"gene": [{"text": "HNF1alpha", "start": 66, "end": 75}, {"text": "HNF4", "start": 85, "end": 89}, {"text": "G6Pase gene", "start": 136, "end": 147}]}}, "schema": []}
{"input": "Differential regulation of the pre-C and pregenomic promoters of human hepatitis B virus by members of the nuclear receptor superfamily.", "output": {"entities": {"gene": [{"text": "pre-C", "start": 31, "end": 36}, {"text": "nuclear receptor superfamily", "start": 107, "end": 135}]}}, "schema": []}
{"input": "These results implicate a precursor-specific base-paired structure involving sequences on both sides of the mature cleavage site in the 3' processing of human U2 RNA.", "output": {"entities": {"gene": [{"text": "human U2 RNA", "start": 153, "end": 165}]}}, "schema": []}
{"input": "The mouse M-lysozyme downstream enhancer has been previously characterized on several levels of gene regulation.", "output": {"entities": {"gene": [{"text": "mouse M-lysozyme downstream enhancer", "start": 4, "end": 40}]}}, "schema": []}
{"input": "Bitter cassava contains cyanogenic glycosides; processing breaks them down to acetone cyanohydrin and hydrogen cyanide.", "output": {"entities": {}}, "schema": []}
{"input": "First, two MCTs using a long electrode, 3 cm in size, were performed in the central area of the tumor, and eight MCTs by a short electrode, 2 cm in size, were done in the peripheral and surrounding area of the tumor.", "output": {"entities": {}}, "schema": []}
{"input": "We also show by immunogold electron microscopy immunocytochemistry that amphiphysin I is localized in the nerve terminal cytomatrix and is partially associated with endocytic intermediates.", "output": {"entities": {"gene": [{"text": "amphiphysin I", "start": 72, "end": 85}]}}, "schema": []}
{"input": "The prescription for apoplexy includes C1-7, T1-9 and L2-4.", "output": {"entities": {}}, "schema": []}
{"input": "Thus, dpp and omb promote both dorsal leg cell fate as well as transdetermination-competent leg disc cells.", "output": {"entities": {"gene": [{"text": "dpp", "start": 6, "end": 9}, {"text": "omb", "start": 14, "end": 17}]}}, "schema": []}
{"input": "These observations provide strong support for the idea that expression of mutant tRNA can confer a mutator phenotype, including the UVM-constitutive phenotype observed in mutA and mutC cells.", "output": {"entities": {"gene": [{"text": "mutA", "start": 171, "end": 175}, {"text": "mutC", "start": 180, "end": 184}]}}, "schema": []}
{"input": "We now demonstrate that CCAAT/enhancer-binding protein (C/EBP) delta is a major component of a PGE2-stimulated DNA-protein complex involving HS3D and find that C/EBPdelta transactivates IGF-I promoter 1 through this site.", "output": {"entities": {"gene": [{"text": "CCAAT/enhancer-binding protein (C/EBP) delta", "start": 24, "end": 68}, {"text": "HS3D", "start": 141, "end": 145}, {"text": "C/EBPdelta", "start": 160, "end": 170}, {"text": "IGF-I promoter 1", "start": 186, "end": 202}]}}, "schema": []}
{"input": "Interleukin-1 levels remained low throughout the course.", "output": {"entities": {"gene": [{"text": "Interleukin-1", "start": 0, "end": 13}]}}, "schema": []}
{"input": "Southern blot analysis of endonuclease-digested genomic DNA from primary chick embryo fibroblasts (CEF) suggested that MEK2 is a single-copy gene in this vertebrate species.", "output": {"entities": {"gene": [{"text": "MEK2", "start": 119, "end": 123}]}}, "schema": []}
{"input": "SCID V (D) J recombination can be partly rescued in T-lymphocytes by either DNA-damaging agents (gamma-irradiation and bieomycin) or a null mutation of the p53 gene, possibly because of transiently elevated DNA repair activity in response to DNA damage or to delayed apoptosis in the absence of p53.", "output": {"entities": {"gene": [{"text": "V", "start": 5, "end": 6}, {"text": "D", "start": 8, "end": 9}, {"text": "J", "start": 11, "end": 12}, {"text": "p53 gene", "start": 156, "end": 164}, {"text": "p53", "start": 295, "end": 298}]}}, "schema": []}
{"input": "The existence of these two categories of strains offers a new genetic system in which the properties of a potential invertebrate retrovirus can be tested.", "output": {"entities": {}}, "schema": []}
{"input": "TSA treatment, however, did not detectably alter enhancer factor binding or the positioning of nuc-1 on the majority of the chromatin templates indicating that protein acetylation and chromatin remodeling may be limiting steps that occur only on transcriptionally competent templates, or that remodeling of nuc-1 requires additional factors.", "output": {"entities": {"gene": [{"text": "nuc-1", "start": 95, "end": 100}, {"text": "nuc-1", "start": 307, "end": 312}]}}, "schema": []}
{"input": "Y15170 (Surf-2, Surf-4), Y15171 (Surf-3, Surf-1, Surf-6), and Y15172 (Surf-5.)]", "output": {"entities": {"gene": [{"text": "Y15170", "start": 0, "end": 6}, {"text": "Surf-2", "start": 8, "end": 14}, {"text": "Surf-4", "start": 16, "end": 22}, {"text": "Y15171", "start": 25, "end": 31}, {"text": "Surf-3", "start": 33, "end": 39}, {"text": "Surf-1", "start": 41, "end": 47}, {"text": "Surf-6", "start": 49, "end": 55}, {"text": "Y15172", "start": 62, "end": 68}, {"text": "Surf-5", "start": 70, "end": 76}]}}, "schema": []}
{"input": "The mean values of the first three components were not significantly different in ARVD patients and control subjects.", "output": {"entities": {}}, "schema": []}
{"input": "However, the signaling cascade utilized by the urokinase receptor is only incompletely understood.", "output": {"entities": {"gene": [{"text": "urokinase receptor", "start": 47, "end": 65}]}}, "schema": []}
{"input": "The interaction between DDB and E2F1 can also be detected by coimmunoprecipitation experiments.", "output": {"entities": {"gene": [{"text": "DDB", "start": 24, "end": 27}, {"text": "E2F1", "start": 32, "end": 36}]}}, "schema": []}
{"input": "Lysine-ketoglutarate reductase and saccharopine dehydrogenase from Arabidopsis thaliana: nucleotide sequence and characterization.", "output": {"entities": {"gene": [{"text": "Lysine-ketoglutarate reductase", "start": 0, "end": 30}, {"text": "saccharopine dehydrogenase", "start": 35, "end": 61}]}}, "schema": []}
{"input": "The pel gene from an Amycolata sp. encoding a pectate lyase (EC 4. 2. 2. 2) was isolated by activity screening a genomic DNA library in Streptomyces lividans TK24.", "output": {"entities": {"gene": [{"text": "pel gene", "start": 4, "end": 12}, {"text": "pectate lyase", "start": 46, "end": 59}, {"text": "EC 4. 2. 2. 2", "start": 61, "end": 74}]}}, "schema": []}
{"input": "In the clinical study, the defect size shown by BMIPP imaging was greater in anterior than in inferior infarcts (p < 0. 001) and correlated well with the risk area revealed by contrast ventriculography (r = 0. 80, p < 0. 0001) CONCLUSION: The above preliminary data, admittedly from a small group of patients, suggest that tomographic BMIPP imaging provides an accurate quantification of defect size by means of a simple threshold technique and, in the subacute phase, permits determination of the amount of myocardium at risk after acute myocardial infarction.", "output": {"entities": {}}, "schema": []}
{"input": "The promoter for HMG-CoA synthase contains two binding sites for the sterol regulatory element-binding proteins (SREBPs).", "output": {"entities": {"gene": [{"text": "HMG-CoA synthase", "start": 17, "end": 33}, {"text": "sterol regulatory element-binding proteins", "start": 69, "end": 111}, {"text": "SREBPs", "start": 113, "end": 119}]}}, "schema": []}
{"input": "Although RAD17, RAD24 and MEC3 are not required for cell cycle arrest when S phase is inhibited by hydroxyurea (HU), they do contribute to the viability of yeast cells grown in the presence of HU, possibly because they are required for the repair of HU-induced DNA damage.", "output": {"entities": {"gene": [{"text": "RAD17", "start": 9, "end": 14}, {"text": "RAD24", "start": 16, "end": 21}, {"text": "MEC3", "start": 26, "end": 30}]}}, "schema": []}
{"input": "Protein C deficiency or protein S deficiency was the only identified risk factor for 5. 4% (2 patients) and 13. 5% (5 patients), respectively, of these 37 children.", "output": {"entities": {"gene": [{"text": "Protein C", "start": 0, "end": 9}, {"text": "protein S", "start": 24, "end": 33}]}}, "schema": []}
{"input": "A reciprocal binding assay using IM-9 cells as a source of SHP-1 and SHP-2 revealed specific association of SHP-2 (but not SHP-1) with a glutathione S-transferase fusion incorporating GHR cytoplasmic domain residues 485-620, but only if the fusion was first rendered tyrosine-phosphorylated.", "output": {"entities": {"gene": [{"text": "SHP-1", "start": 59, "end": 64}, {"text": "SHP-2", "start": 69, "end": 74}, {"text": "SHP-2", "start": 108, "end": 113}, {"text": "SHP-1", "start": 123, "end": 128}, {"text": "glutathione S-transferase fusion", "start": 137, "end": 169}, {"text": "GHR cytoplasmic domain residues 485-620", "start": 184, "end": 223}]}}, "schema": []}
{"input": "We have used mutation-directed chemical cross-linking with bis (sulfosuccinimidyl) suberate (BS3) to investigate the architecture of the gp41 oligomer.", "output": {"entities": {"gene": [{"text": "gp41 oligomer", "start": 137, "end": 150}]}}, "schema": []}
{"input": "Consistent with previous reports, addition of a myristoylation signal to mSos1 (MyrSos1) rendered it transforming for NIH 3T3 cells and deletion of the mSos C terminus (MyrSos1-deltaC) did not interfere with this activity.", "output": {"entities": {"gene": [{"text": "mSos1", "start": 73, "end": 78}, {"text": "MyrSos1", "start": 80, "end": 87}, {"text": "mSos C terminus", "start": 152, "end": 167}, {"text": "MyrSos1-deltaC", "start": 169, "end": 183}]}}, "schema": []}
{"input": "Demonstration of tissue lesions after intramuscular injection by determination of creatine kinase in blood", "output": {"entities": {"gene": [{"text": "creatine kinase", "start": 82, "end": 97}]}}, "schema": []}
{"input": "Levels of the MEK inhibitor PD98059 that block EGF-induced mitogenesis and MAP kinase phosphorylation also abrogate EGF-induced focal adhesion disassembly and cell motility.", "output": {"entities": {"gene": [{"text": "MEK", "start": 14, "end": 17}, {"text": "EGF", "start": 47, "end": 50}, {"text": "MAP kinase", "start": 75, "end": 85}, {"text": "EGF", "start": 116, "end": 119}]}}, "schema": []}
{"input": "Surprisingly, the COOH-terminal domain of RanGAP1 was also found to harbor a nuclear localization signal.", "output": {"entities": {"gene": [{"text": "RanGAP1", "start": 42, "end": 49}]}}, "schema": []}
{"input": "Here, we present evidence that exposure of DT40 lymphoma B cells to low energy electromagnetic field (EMF) results in a tyrosine kinase-dependent activation of phospholipase Cgamma2 (PLC-gamma2) leading to increased inositol phospholipid turnover.", "output": {"entities": {"gene": [{"text": "tyrosine kinase", "start": 120, "end": 135}, {"text": "phospholipase Cgamma2", "start": 160, "end": 181}, {"text": "PLC-gamma2", "start": 183, "end": 193}]}}, "schema": []}
{"input": "PATIENTS AND METHOD: Since 1986, 62 patients were irradiated stereotactically.", "output": {"entities": {}}, "schema": []}
{"input": "Training for audit.", "output": {"entities": {}}, "schema": []}
{"input": "Cytoskeletal polarization of T cells is regulated by an immunoreceptor tyrosine-based activation motif-dependent mechanism.", "output": {"entities": {}}, "schema": []}
{"input": "Here we have examined the ability of the cellular protein YB-1 to modulate transcription of the HIV-1 promoter in a human astrocytic cell line (U-87MG), a neuronal cell line (SK-N-MC) and lymphoid cells (Jurkat) by transfection assay.", "output": {"entities": {"gene": [{"text": "YB-1", "start": 58, "end": 62}, {"text": "HIV-1 promoter", "start": 96, "end": 110}]}}, "schema": []}
{"input": "Substrates for p210 (bcr-abl) are likely to be involved in the pathogenesis of CML.", "output": {"entities": {"gene": [{"text": "p210", "start": 15, "end": 19}, {"text": "bcr", "start": 21, "end": 24}, {"text": "abl", "start": 25, "end": 28}]}}, "schema": []}
{"input": "The COOH-terminal region of the transcripts contained fifteen triplet repeats (GCT; alanine) at nucleotide 465 to 509, which is significantly expanded compared to the rat RL14.", "output": {"entities": {"gene": [{"text": "rat RL14", "start": 167, "end": 175}]}}, "schema": []}
{"input": "Control of fatty liver syndrome in a Jersey herd by a change of diet and the use of recombinant bovine somatotrophin.", "output": {"entities": {"gene": [{"text": "somatotrophin", "start": 103, "end": 116}]}}, "schema": []}
{"input": "During organogenesis, HFH-8 expression is found in the splanchnic mesoderm in close apposition of the gut endoderm, suggesting a role in mesenchymal-epithelial induction of lung and gut morphogenesis.", "output": {"entities": {"gene": [{"text": "HFH-8", "start": 22, "end": 27}]}}, "schema": []}
{"input": "However, laparoscopy failed to establish inoperability in any cases of carcinoma spread to areas not accessible to laparoscopic visualization.", "output": {"entities": {}}, "schema": []}
{"input": "No difference in telomere length was seen in mutants affected in the regulation of Cdc2, whereas some of the DNA repair mutants examined had slightly longer telomeres than did the wild type.", "output": {"entities": {"gene": [{"text": "Cdc2", "start": 83, "end": 87}]}}, "schema": []}
{"input": "Sp1 can activate transcription through immunoglobulin kappa-chain enhancer or P-selectin promoter NF-kappaB sites. p50 homodimers replace Sp1 from the P-selectin promoter by binding site competition and thereby either inhibit basal Sp1-driven expression or, in concert with Bcl-3, stimulate expression.", "output": {"entities": {"gene": [{"text": "Sp1", "start": 0, "end": 3}, {"text": "immunoglobulin kappa-chain enhancer", "start": 39, "end": 74}, {"text": "P-selectin promoter NF-kappaB sites", "start": 78, "end": 113}, {"text": "p50 homodimers", "start": 115, "end": 129}, {"text": "Sp1", "start": 138, "end": 141}, {"text": "P-selectin promoter", "start": 151, "end": 170}, {"text": "Sp1", "start": 232, "end": 235}, {"text": "Bcl-3", "start": 274, "end": 279}]}}, "schema": []}
{"input": "For the 5HT5A receptor the addition of yohimbine resulted in a similar but smaller effect.", "output": {"entities": {"gene": [{"text": "5HT5A receptor", "start": 8, "end": 22}]}}, "schema": []}
{"input": "CONCLUSIONS: XCoe2 may play a pivotal role in the transcriptional cascade that specifies primary neurons in Xenopus embryos: by maintaining Delta-Notch signalling, XCoe2 stabilises the higher neural potential of selected progenitor cells that express X-ngnr-1, ensuring the transition between neural competence and irreversible commitment to a neural fate; and it promotes neuronal differentiation by activating XNeuroD expression, directly or indirectly.", "output": {"entities": {"gene": [{"text": "XCoe2", "start": 13, "end": 18}, {"text": "Delta", "start": 140, "end": 145}, {"text": "Notch", "start": 146, "end": 151}, {"text": "XCoe2", "start": 164, "end": 169}, {"text": "X-ngnr-1", "start": 251, "end": 259}, {"text": "XNeuroD", "start": 412, "end": 419}]}}, "schema": []}
{"input": "RESULTS: Patients in Group A had a higher incidence of posterolateral wall motion abnormalities (p < 0. 001) on radionuclide ventriculography, a larger infarct area (as evidenced by higher peak creatine kinase levels) (p < 0. 02) and a lower left ventricular ejection fraction (LVEF) at hospital discharge (p < 0. 008) than those in Group B.", "output": {"entities": {"gene": [{"text": "creatine kinase", "start": 194, "end": 209}]}}, "schema": []}
{"input": "In all cells, the accumulation of high Dsg protein levels required calcium and was not observed in low calcium (0. 05-0. 07 mM) media.", "output": {"entities": {"gene": [{"text": "Dsg protein", "start": 39, "end": 50}]}}, "schema": []}
{"input": "RESULTS: Using information in the dbEST database of expressed sequence tags, we isolated an Arabidopsis thaliana gene (GCR1) that encodes a protein with seven predicted membrane-spanning domains and other features characteristic of 7TM receptors.", "output": {"entities": {"gene": [{"text": "GCR1", "start": 119, "end": 123}, {"text": "7TM receptors", "start": 232, "end": 245}]}}, "schema": []}
{"input": "E1A represses apolipoprotein AI enhancer activity in liver cells through a pRb-and CBP-independent pathway.", "output": {"entities": {"gene": [{"text": "E1A", "start": 0, "end": 3}, {"text": "apolipoprotein AI enhancer", "start": 14, "end": 40}, {"text": "pRb", "start": 75, "end": 78}, {"text": "CBP", "start": 83, "end": 86}]}}, "schema": []}
{"input": "M-66 identified the 14-kDa protein in another MMTV bearing T-cell lymphoma, EL-4.", "output": {"entities": {"gene": [{"text": "M-66", "start": 0, "end": 4}]}}, "schema": []}
{"input": "RT-PCR indicated that p21 mRNA was induced 1. 4-, 2. 0-, and 3. 1-fold in the 2-day neonatal, 7-day neonatal, and adult stages, respectively, compared to the 17-day fetal stage.", "output": {"entities": {"gene": [{"text": "p21 mRNA", "start": 22, "end": 30}]}}, "schema": []}
{"input": "Ganciclovir and foscarnet efficacy in AIDS-related CMV polyradiculopathy.", "output": {"entities": {}}, "schema": []}
{"input": "BACKGROUND AND OBJECTIVES: The sexually transmitted diseases (STD) control program for female sex workers (FSW) in Lima, Peru, provided periodic serological tests for syphilis and cervical smears for gonococci, but not medication for STD or condoms.", "output": {"entities": {}}, "schema": []}
{"input": "In order to examine the potential role of transcriptional silencing during productive HSV-1 infection, recombinant viruses were generated in which wild-type or mutant ICP34. 5 promoters controlling the expression of a chloramphenicol acetyltransferase reporter gene were inserted into the thymidine kinase gene of the viral genome.", "output": {"entities": {"gene": [{"text": "wild-type or mutant ICP34. 5 promoters", "start": 147, "end": 185}, {"text": "chloramphenicol acetyltransferase reporter gene", "start": 218, "end": 265}, {"text": "thymidine kinase gene", "start": 289, "end": 310}]}}, "schema": []}
{"input": "Members of the meis1 and pbx homeodomain protein families cooperatively bind a cAMP-responsive sequence (CRS1) from bovine CYP17.", "output": {"entities": {"gene": [{"text": "meis1", "start": 15, "end": 20}, {"text": "pbx homeodomain protein families", "start": 25, "end": 57}, {"text": "bovine CYP17", "start": 116, "end": 128}]}}, "schema": []}
{"input": "The RAS-cyclic AMP-dependent protein kinase cAPK pathway prevents the UAS activity of IREu in the presence of glucose as the sole carbon source, while the transcriptional activators Msn2p and Msn4p promote the UAS activity of this repeat in the presence of acetate.", "output": {"entities": {"gene": [{"text": "RAS", "start": 4, "end": 7}, {"text": "cyclic AMP-dependent protein kinase cAPK", "start": 8, "end": 48}, {"text": "IREu", "start": 86, "end": 90}, {"text": "Msn2p", "start": 182, "end": 187}, {"text": "Msn4p", "start": 192, "end": 197}]}}, "schema": []}
{"input": "Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) is an example of highly regulated alternative splicing in which exons IIIb and IIIc are utilized in a mutually exclusive manner in different cell types.", "output": {"entities": {"gene": [{"text": "fibroblast growth factor receptor 2", "start": 24, "end": 59}, {"text": "FGF-R2", "start": 61, "end": 67}]}}, "schema": []}
{"input": "SNAC or PBS was infused for 6. 5 h, beginning 30 min before ischemia and continuing throughout the duration of reperfusion.", "output": {"entities": {}}, "schema": []}
{"input": "Moreover, it is the assumptions behind steady-state O2 uptake that do not permit proper interpretation of energy expenditure during EPOC; 1 l O2 not = 20. 9 kJ.", "output": {"entities": {}}, "schema": []}
{"input": "The predicted amino acid sequence of m-Staf is highly homologous to that of Staf, another selenocysteine tRNA gene transcription activating factor of Xenopus laevis.", "output": {"entities": {"gene": [{"text": "m-Staf", "start": 37, "end": 43}, {"text": "Staf", "start": 76, "end": 80}, {"text": "selenocysteine tRNA gene transcription activating factor", "start": 90, "end": 146}]}}, "schema": []}
{"input": "Recent studies have revealed unconventional myosin V to be an important actin-based molecular motor involved in vesicular movement.", "output": {"entities": {"gene": [{"text": "myosin V", "start": 44, "end": 52}, {"text": "actin", "start": 72, "end": 77}]}}, "schema": []}
{"input": "Furthermore, a minor start site was localized 179 bp upstream of the major site using reverse transcriptase-polymerase chain reaction with various P1 primers (primer walking), primer extension, and cDNA cloning.", "output": {"entities": {"gene": [{"text": "reverse transcriptase", "start": 86, "end": 107}]}}, "schema": []}
{"input": "Analysis of promoter and androgen regulatory sequences required for optimal transcription of the rat androgen-binding protein gene.", "output": {"entities": {"gene": [{"text": "androgen-binding protein", "start": 101, "end": 125}]}}, "schema": []}
{"input": "In a gntR deletion mutant, the expression of a chromosomal gntT:: lacZ fusion is both high and constitutive, confirming that GntR is the negative regulator of gntT.", "output": {"entities": {"gene": [{"text": "gntR deletion mutant", "start": 5, "end": 25}, {"text": "gntT", "start": 59, "end": 63}, {"text": "lacZ", "start": 66, "end": 70}, {"text": "GntR", "start": 125, "end": 129}, {"text": "gntT", "start": 159, "end": 163}]}}, "schema": []}
{"input": "Therefore, we conclude that DnaA may contact the beta subunit of RNA polymerase during activation of the pR promoter.", "output": {"entities": {"gene": [{"text": "DnaA", "start": 28, "end": 32}, {"text": "RNA polymerase", "start": 65, "end": 79}, {"text": "pR promoter", "start": 105, "end": 116}]}}, "schema": []}
{"input": "Expression of Bcl-XL inhibited the association of Apaf-1 with caspase-9 in mammalian cells.", "output": {"entities": {"gene": [{"text": "Bcl-XL", "start": 14, "end": 20}, {"text": "Apaf-1", "start": 50, "end": 56}, {"text": "caspase-9", "start": 62, "end": 71}]}}, "schema": []}
{"input": "Whole-mount in situ hybridization to early mouse embryos of 9. 5-10. 5 days indicated a complex pattern of Arp1 expression spatially overlapping with the expression of All1.", "output": {"entities": {"gene": [{"text": "Arp1", "start": 107, "end": 111}, {"text": "All1", "start": 168, "end": 172}]}}, "schema": []}
{"input": "Creatine kinase release after hepatic artery embolization in patients with carcinoid tumors.", "output": {"entities": {"gene": [{"text": "Creatine kinase", "start": 0, "end": 15}]}}, "schema": []}
{"input": "Our observations suggest that members of the HMG-I family play an important role in SRF-dependent transcription and that their effect is mediated primarily by a protein-protein interaction.", "output": {"entities": {"gene": [{"text": "HMG-I family", "start": 45, "end": 57}, {"text": "SRF", "start": 84, "end": 87}]}}, "schema": []}
{"input": "We recently characterized a single yeast hnRNP methyltransferase (HMT1).", "output": {"entities": {"gene": [{"text": "yeast hnRNP methyltransferase", "start": 35, "end": 64}, {"text": "HMT1", "start": 66, "end": 70}]}}, "schema": []}
{"input": "We recently characterized a single yeast hnRNP methyltransferase (HMT1).", "output": {"entities": {"gene": [{"text": "yeast hnRNP methyltransferase", "start": 35, "end": 64}, {"text": "HMT1", "start": 66, "end": 70}]}}, "schema": []}
{"input": "Recombinant HRMT1L2 protein encoded by the most common 5'-variant exhibited methyltransferase activity in vitro.", "output": {"entities": {"gene": [{"text": "Recombinant HRMT1L2 protein", "start": 0, "end": 27}]}}, "schema": []}
{"input": "The possible roles of HRMT1L1 and HRMT1L2 in human disease are currently unknown.", "output": {"entities": {"gene": [{"text": "HRMT1L1", "start": 22, "end": 29}, {"text": "HRMT1L2", "start": 34, "end": 41}]}}, "schema": []}
{"input": "Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2).", "output": {"entities": {"gene": [{"text": "human arginine methyltransferases", "start": 52, "end": 85}, {"text": "HRMT1L1", "start": 87, "end": 94}, {"text": "HRMT1L2", "start": 99, "end": 106}]}}, "schema": []}
{"input": "To identify nuclear regulatory factors, we have located and functionally characterized the CCR5 gene promoter.", "output": {"entities": {"gene": [{"text": "CCR5 gene promoter", "start": 91, "end": 109}]}}, "schema": []}
{"input": "The interaction between piroxicam and poloxamer was studied by x-ray diffractometry (XRD), infrared (IR) spectroscopy and differential thermal analysis (DTA) with a solid dispersion, coprecipitate, or physical mixture.", "output": {"entities": {}}, "schema": []}
{"input": "The results confirm that a single base change in the branchpoint consensus sequence of an intron can cause human disease although this sequence is poorly conserved in mammals.", "output": {"entities": {}}, "schema": []}
{"input": "It bound to vitamin D receptor (VDR) but not retinoic acid Xalpha receptor (RXRalpha) in the human T cell line MT2 cells.", "output": {"entities": {"gene": [{"text": "vitamin D receptor", "start": 12, "end": 30}, {"text": "VDR", "start": 32, "end": 35}, {"text": "retinoic acid Xalpha receptor", "start": 45, "end": 74}, {"text": "RXRalpha", "start": 76, "end": 84}]}}, "schema": []}
{"input": "Based on the current literature, the mechanisms involved in the toxicity of OA indicate three major effects: (1) inhibition of mitochondrial respiration correlated with a depletion of ATP; (2) inhibition of tRNA-synthetase accompanied by a reduced protein synthesis; and (3) enhanced lipid peroxidation.", "output": {"entities": {"gene": [{"text": "OA", "start": 76, "end": 78}, {"text": "tRNA-synthetase", "start": 207, "end": 222}]}}, "schema": []}
{"input": "Another stem-loop called structure III near the 3'-end of repY sequesters both the 5'-rCGCC-3' sequence and the repZ ribosome-binding site.", "output": {"entities": {"gene": [{"text": "repY", "start": 58, "end": 62}, {"text": "repZ ribosome-binding site", "start": 112, "end": 138}]}}, "schema": []}
{"input": "The general transcription factor IIA (TFIIA) interacts with the TATA binding protein (TBP) and promoter DNA to mediate transcription activation in vitro.", "output": {"entities": {"gene": [{"text": "transcription factor IIA", "start": 12, "end": 36}, {"text": "TFIIA", "start": 38, "end": 43}, {"text": "TATA binding protein", "start": 64, "end": 84}, {"text": "TBP", "start": 86, "end": 89}]}}, "schema": []}
{"input": "Localization of 67 exons on a YAC contig spanning 1. 5 Mb around the multidrug resistance gene region of human chromosome 7q21. 1.", "output": {"entities": {"gene": [{"text": "multidrug resistance gene region", "start": 69, "end": 101}]}}, "schema": []}
{"input": "Using Southern blot analysis and restriction mapping of genomic YAC (yeast artificial chromosome) and cosmid clones, we located the human RIL gene 240-260 kb telomeric to the IRF1 gene and characterized its genomic structure.", "output": {"entities": {"gene": [{"text": "human RIL gene", "start": 132, "end": 146}, {"text": "IRF1 gene", "start": 175, "end": 184}]}}, "schema": []}
{"input": "U73 contains C, D and D' boxes and a 12-nucleotide antisense complementarity to the 28S ribosomal RNA.", "output": {"entities": {"gene": [{"text": "U73", "start": 0, "end": 3}, {"text": "28S ribosomal RNA", "start": 84, "end": 101}]}}, "schema": []}
{"input": "However, mandibular position (S-N-B and S-N-Pog) was found to be significantly more retrusive in Class II when compared with Class I subjects.", "output": {"entities": {}}, "schema": []}
{"input": "Echinostomiasis is aggravated by socioeconomic factors such as poverty, malnutrition, an explosively growing free-food market, a lack of supervised food inspection, poor or insufficient sanitation, other helminthiases, and declining economic conditions.", "output": {"entities": {}}, "schema": []}
{"input": "The localization of ZAP-70 to the cell cortex is, therefore, regulated by the activity of SRC-family kinases, independently of their ability to phosphorylate immunoreceptor tyrosine-based activation motifs of the TCR.", "output": {"entities": {"gene": [{"text": "ZAP-70", "start": 20, "end": 26}, {"text": "SRC-family kinases", "start": 90, "end": 108}, {"text": "TCR", "start": 213, "end": 216}]}}, "schema": []}
{"input": "The effect of nitric oxide synthase inhibitor on reperfusion injury of the brain under hypothermic circulatory arrest.", "output": {"entities": {"gene": [{"text": "nitric oxide synthase", "start": 14, "end": 35}]}}, "schema": []}
{"input": "UDP-GlcNAc: alpha-6-D-mannoside beta-1, 2-N-acetylglucosaminyltransferase II (GnT II; EC 2. 4. 1. 143) is essential for the normal assembly of complex Asn-linked glycans.", "output": {"entities": {"gene": [{"text": "UDP-GlcNAc", "start": 0, "end": 10}, {"text": "alpha-6-D-mannoside beta-1, 2-N-acetylglucosaminyltransferase II", "start": 12, "end": 76}, {"text": "GnT II", "start": 78, "end": 84}, {"text": "EC 2. 4. 1. 143", "start": 86, "end": 101}]}}, "schema": []}
{"input": "Taken together, these results suggest that silymarin may exert a strong anticarcinogenic effect against PCA and that this effect is likely to involve impairment of erbB1-SHC-mediated signaling pathway, induction of CDKIs, and a resultant G1 arrest.", "output": {"entities": {"gene": [{"text": "erbB1", "start": 164, "end": 169}, {"text": "SHC", "start": 170, "end": 173}, {"text": "CDKIs", "start": 215, "end": 220}]}}, "schema": []}
{"input": "In connective tissue, cell structure contributes to type I collagen expression.", "output": {"entities": {"gene": [{"text": "type I collagen", "start": 52, "end": 67}]}}, "schema": []}
{"input": "A point mutation in Galphao and Galphai1 blocks interaction with regulator of G protein signaling proteins.", "output": {"entities": {"gene": [{"text": "Galphao", "start": 20, "end": 27}, {"text": "Galphai1", "start": 32, "end": 40}, {"text": "G protein", "start": 78, "end": 87}]}}, "schema": []}
{"input": "Indeed, it is shown that it mediates the formation of disulfide-linked homodimers and that the formation of homo-and heterodimers are mutually excluded.", "output": {"entities": {}}, "schema": []}
{"input": "N., and Fanning, E.", "output": {"entities": {}}, "schema": []}
{"input": "In patients with type IA maple syrup urine disease, the E1alpha subunit is affected, resulting in the loss of E1 and branched-chain ketoacid dehydrogenase catalytic activities.", "output": {"entities": {"gene": [{"text": "E1alpha subunit", "start": 56, "end": 71}, {"text": "E1", "start": 110, "end": 112}, {"text": "branched-chain ketoacid dehydrogenase", "start": 117, "end": 154}]}}, "schema": []}
{"input": "All patients diagnosed of H. influenza type b meningitis were less than 3 years old.", "output": {"entities": {}}, "schema": []}
{"input": "Immunohistochemically, anticytokeratin 19 antibody revealed strong staining in both epithelial and sarcomatous MPM tissues.", "output": {"entities": {"gene": [{"text": "anticytokeratin 19 antibody", "start": 23, "end": 50}]}}, "schema": []}
{"input": "Combined expression of c-Jun and p65 induced vigorous transcription of IL-2 promoter-and CD28RE-driven reporter constructs in both LFA-3-and B7-1-costimulated Jurkat cells.", "output": {"entities": {"gene": [{"text": "c-Jun", "start": 23, "end": 28}, {"text": "p65", "start": 33, "end": 36}, {"text": "IL-2", "start": 71, "end": 75}, {"text": "CD28RE-driven reporter constructs", "start": 89, "end": 122}, {"text": "LFA-3", "start": 131, "end": 136}, {"text": "B7-1", "start": 141, "end": 145}]}}, "schema": []}
{"input": "Liquid chromatographic method for analysis of all-rac-alpha-tocopheryl acetate and retinyl palmitate in milk-based infant formula using matrix solid-phase dispersion.", "output": {"entities": {}}, "schema": []}
{"input": "The ability to maintain expression of FAS1 in nmt1-451Dino2 Delta cells suggests the existence of another transcription factor, or factors, whose expression/activity is inversely related to overall levels of cellular protein N-myristoy-lation.", "output": {"entities": {"gene": [{"text": "FAS1", "start": 38, "end": 42}, {"text": "nmt1", "start": 46, "end": 50}, {"text": "451Dino2", "start": 51, "end": 59}]}}, "schema": []}
{"input": "The identified isolates of CSF (20 of 29) were: ECHO 30 (9), ECHO 11 (7), ECHO 9 (3) and ECHO 7 (1).", "output": {"entities": {}}, "schema": []}
{"input": "There was no evidence of any persistent oscillation within the ULF band.", "output": {"entities": {}}, "schema": []}
{"input": "A large deletion in the CTD-binding motif blocks down-regulation but does not affect the essential function of Nrd1.", "output": {"entities": {"gene": [{"text": "CTD-binding motif", "start": 24, "end": 41}, {"text": "Nrd1", "start": 111, "end": 115}]}}, "schema": []}
{"input": "Thus, included in the KG1a EST dataset are candidates for new human genes that may play roles in hematopoietic differentiative progression and lineage commitment.", "output": {"entities": {}}, "schema": []}
{"input": "Sp1 and two Sp3 isoforms were detected as the primary cellular constituents of DNA-protein complexes formed with the NF-kappaB-proximal site.", "output": {"entities": {"gene": [{"text": "Sp1", "start": 0, "end": 3}, {"text": "Sp3 isoforms", "start": 12, "end": 24}, {"text": "NF-kappaB-proximal site", "start": 117, "end": 140}]}}, "schema": []}
{"input": "The second patient had received pituitary-derived growth hormone for treatment of growth hormone deficiency, secondary to a third ventricle teratoma, exised 13 yr earlier.", "output": {"entities": {"gene": [{"text": "pituitary-derived growth hormone", "start": 32, "end": 64}, {"text": "growth hormone", "start": 82, "end": 96}]}}, "schema": []}
{"input": "Binding affinities of different nucleotide mono-, di-and triphosphates and non-hydrolyzable analogs indicate that the beta-phosphate moiety is required for substrate binding.", "output": {"entities": {}}, "schema": []}
{"input": "[Treatment of early T1 small T2N breast cancers.", "output": {"entities": {}}, "schema": []}
{"input": "Malaria had diminished significantly by the early 1940s, and this paper queries whether that reduction was due to the control projects of the thirties, and, if so, whether such projects should be a model for the current developing world, where malaria is a growing problem today.", "output": {"entities": {}}, "schema": []}
{"input": "Fowlpox virus encodes nonessential homologs of cellular alpha-SNAP, PC-1, and an orphan human homolog of a secreted nematode protein.", "output": {"entities": {"gene": [{"text": "cellular alpha-SNAP", "start": 47, "end": 66}, {"text": "PC-1", "start": 68, "end": 72}]}}, "schema": []}
{"input": "Further, Ser/Thr phosphorylation of downstream molecules Akt and p70 S6 kinase was inhibited.", "output": {"entities": {"gene": [{"text": "Akt", "start": 57, "end": 60}, {"text": "p70 S6 kinase", "start": 65, "end": 78}]}}, "schema": []}
{"input": "Quantitative evaluation of the steady state kinetics of MEK inhibition by these compounds reveals that U0126 has approximately 100-fold higher affinity for deltaN3-S218E/S222D MEK than does PD098059.", "output": {"entities": {"gene": [{"text": "MEK", "start": 56, "end": 59}, {"text": "deltaN3-S218E/S222D MEK", "start": 156, "end": 179}]}}, "schema": []}
{"input": "However, little is known regarding the genomic organization and developmental expression of the caveolin gene family.", "output": {"entities": {"gene": [{"text": "caveolin gene family", "start": 96, "end": 116}]}}, "schema": []}
{"input": "Tensile bond strengths between resin composite and bovine dentin using dentin adhesive systems (Clearfil Liner Bond II: LB II; Scotchbond Multi-Purpose: MP) bonding systems showed a large scatter among students and dentists.", "output": {"entities": {}}, "schema": []}
{"input": "To better understand the role of Ets proteins in Ras transformation, we have now analyzed the effects of stably expressing a variety of Ets2 constructs in Ras-transformed NIH3T3 (DT) cells.", "output": {"entities": {"gene": [{"text": "Ets proteins", "start": 33, "end": 45}, {"text": "Ras", "start": 49, "end": 52}, {"text": "Ets2 constructs", "start": 136, "end": 151}, {"text": "Ras", "start": 155, "end": 158}]}}, "schema": []}
{"input": "Manipulation of the checkpoint regulators involved in cell cycle arrest and apoptosis may thus provide a novel strategy to cancer therapy.", "output": {"entities": {}}, "schema": []}
{"input": "The diagnostic accuracy of serum PE-1 was 0. 80, and that of amylase 0. 97.", "output": {"entities": {"gene": [{"text": "PE-1", "start": 33, "end": 37}, {"text": "amylase", "start": 61, "end": 68}]}}, "schema": []}
{"input": "We demonstrate that Ddc1p interacts physically in vivo with Mec3p, and this interaction requires Rad17p.", "output": {"entities": {"gene": [{"text": "Ddc1p", "start": 20, "end": 25}, {"text": "Mec3p", "start": 60, "end": 65}, {"text": "Rad17p", "start": 97, "end": 103}]}}, "schema": []}
{"input": "Deleting SNF1 repressed meiosis at the same three steps that were inhibited by glucose, suggesting that glucose blocks meiosis by inhibiting Snf1.", "output": {"entities": {"gene": [{"text": "SNF1", "start": 9, "end": 13}, {"text": "Snf1", "start": 141, "end": 145}]}}, "schema": []}
{"input": "Ligand-independent activation of platelet-derived growth factor receptor is a necessary intermediate in lysophosphatidic, acid-stimulated mitogenic activity in L cells.", "output": {"entities": {"gene": [{"text": "platelet-derived growth factor receptor", "start": 33, "end": 72}]}}, "schema": []}
{"input": "In canrenoate-treated rats, ANP infusion caused greater increases in sodium excretion (FENA from 3. 05 +/-0. 71 to 7. 21 +/-0. 45%; P < 0. 05; n = 8) than saline infusion (FENA from 4. 16 +/-1. 11 to 5. 47 +/-0. 66%; n = 6), despite the hypocapnia.", "output": {"entities": {"gene": [{"text": "ANP", "start": 28, "end": 31}]}}, "schema": []}
{"input": "Identical c-erbB3 transcripts are expressed in normal human placental tissues.", "output": {"entities": {"gene": [{"text": "c-erbB3 transcripts", "start": 10, "end": 29}]}}, "schema": []}
{"input": "Downregulation of FUS expression in BCR/ABL-expressing 32Dcl3 cells was associated with suppression of growth factor-independent colony formation, restoration of G-CSF-induced granulocytic differentiation and reduced tumorigenic potential in vivo.", "output": {"entities": {"gene": [{"text": "FUS", "start": 18, "end": 21}, {"text": "BCR", "start": 36, "end": 39}, {"text": "ABL", "start": 40, "end": 43}, {"text": "G-CSF", "start": 162, "end": 167}]}}, "schema": []}
{"input": "We propose a model in which Sro7 function is involved in the targeting of the myosin proteins to their intrinsic pathways.", "output": {"entities": {"gene": [{"text": "Sro7", "start": 28, "end": 32}, {"text": "myosin proteins", "start": 78, "end": 93}]}}, "schema": []}
{"input": "In experiments with the D1 antagonist SCH 23390, buprenorphine-induced depression was consistently blocked, but facilitation was unaffected.", "output": {"entities": {}}, "schema": []}
{"input": "Acute idiopathic thrombocytopenic purpura presenting a high serum level of immunoglobulin E and eosinophilia in an elderly patient.", "output": {"entities": {"gene": [{"text": "immunoglobulin E", "start": 75, "end": 91}]}}, "schema": []}
{"input": "The purpose of this article is to discuss the factors involved in the selection of antibodies, radionuclides and labeling methods in the development of radioimmunotherapy (RIT) for non-Hodgkin' s lymphoma (NHL) from a single clinical study site through multicenter trials and commercialization.", "output": {"entities": {}}, "schema": []}
{"input": "Transcriptional regulation of the GluR2 gene: neural-specific expression, multiple promoters, and regulatory elements.", "output": {"entities": {"gene": [{"text": "GluR2 gene", "start": 34, "end": 44}]}}, "schema": []}
{"input": "The binding of NF-ATp, although not NF-AT4, to this enhancer also occurs along with HTLV-I-mediated infection of human peripheral blood T-cells.", "output": {"entities": {"gene": [{"text": "NF-ATp", "start": 15, "end": 21}, {"text": "NF-AT4", "start": 36, "end": 42}]}}, "schema": []}
{"input": "Thus, TRAF2 initiates SAPK and p38 activation by binding two proximal protein kinases: GCK and RIP.", "output": {"entities": {"gene": [{"text": "TRAF2", "start": 6, "end": 11}, {"text": "SAPK", "start": 22, "end": 26}, {"text": "p38", "start": 31, "end": 34}, {"text": "GCK", "start": 87, "end": 90}, {"text": "RIP", "start": 95, "end": 98}]}}, "schema": []}
{"input": "Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38.", "output": {"entities": {"gene": [{"text": "Tumor necrosis factor", "start": 0, "end": 21}, {"text": "stress-activated protein kinase", "start": 35, "end": 66}, {"text": "SAPK", "start": 68, "end": 72}, {"text": "Jun NH2-terminal kinase", "start": 74, "end": 97}, {"text": "JNK", "start": 99, "end": 102}, {"text": "p38", "start": 108, "end": 111}]}}, "schema": []}
{"input": "The activity of the minimal promoter was found to be controlled by a combination of the activities of the transcription factors Sp1, Sp3, and NF-Y.", "output": {"entities": {"gene": [{"text": "Sp1", "start": 128, "end": 131}, {"text": "Sp3", "start": 133, "end": 136}, {"text": "NF-Y", "start": 142, "end": 146}]}}, "schema": []}
{"input": "Pressure ulcers.", "output": {"entities": {}}, "schema": []}
{"input": "TBP can be phosphorylated in vitro by extracts of U937 cells or by bacterially expressed activated ERK2; the phosphorylation sites were mapped to ERK kinase consensus sites in the TBP amino-terminal domain.", "output": {"entities": {"gene": [{"text": "TBP", "start": 0, "end": 3}, {"text": "ERK2", "start": 99, "end": 103}, {"text": "ERK kinase consensus sites", "start": 146, "end": 172}, {"text": "TBP amino-terminal domain", "start": 180, "end": 205}]}}, "schema": []}
{"input": "During the CR/PP diet only the HS subjects did not show the stress-induced rise in depression, decline in vigour and cortisol elevation that they showed after the PR/CP diet.", "output": {"entities": {}}, "schema": []}
{"input": "Evidence for a novel MAPKKK-independent pathway controlling the stress activated Sty1/Spc1 MAP kinase in fission yeast.", "output": {"entities": {"gene": [{"text": "MAPKKK", "start": 21, "end": 27}, {"text": "Sty1", "start": 81, "end": 85}, {"text": "Spc1", "start": 86, "end": 90}]}}, "schema": []}
{"input": "Furthermore, we demonstrated that Galpha11 Q209L stimulated Src family kinase activity and induced tyrosine phosphorylation of several proteins in HEK-293 cells.", "output": {"entities": {"gene": [{"text": "Galpha11 Q209L", "start": 34, "end": 48}, {"text": "Src family", "start": 60, "end": 70}]}}, "schema": []}
{"input": "The micturition pressure was significantly decreased only after injection with BUP-4 in both normal and obstructed rats.", "output": {"entities": {}}, "schema": []}
{"input": "Peroxisome proliferator-activated receptors (PPAR) modulate transcription by binding to specific peroxisome proliferator-response elements (PPRE) through heterodimerization with the 9-cis retinoic acid receptor (RXR).", "output": {"entities": {"gene": [{"text": "Peroxisome proliferator-activated receptors", "start": 0, "end": 43}, {"text": "PPAR", "start": 45, "end": 49}, {"text": "9-cis retinoic acid receptor", "start": 182, "end": 210}, {"text": "RXR", "start": 212, "end": 215}]}}, "schema": []}
{"input": "Molecular cloning and functional characterization of murine sphingosine kinase.", "output": {"entities": {"gene": [{"text": "murine sphingosine kinase", "start": 53, "end": 78}]}}, "schema": []}
{"input": "Our results show that, from a thermodynamical standpoint, melatonin may directly scavenge hydroxyl radicals both in vacuum and in aqueous solution.", "output": {"entities": {}}, "schema": []}
{"input": "This sequence, Thr-Gly-X-X-Gly-Asp-Gly-Lys-Ile-Phe, forms part of the B-loop and is conserved in a wide variety of organisms that include bacteria, algae and archeabacteria.", "output": {"entities": {}}, "schema": []}
{"input": "The only abundant viral transcript expressed during latency is the latency-related (LR) RNA.", "output": {"entities": {"gene": [{"text": "latency-related", "start": 67, "end": 82}, {"text": "LR", "start": 84, "end": 86}]}}, "schema": []}
{"input": "Expression of constitutively active MEK1, the kinase that activates ERKs, or overexpression of ERK2, but not JNK1, inhibited Stat3 activation.", "output": {"entities": {"gene": [{"text": "MEK1", "start": 36, "end": 40}, {"text": "ERKs", "start": 68, "end": 72}, {"text": "ERK2", "start": 95, "end": 99}, {"text": "JNK1", "start": 109, "end": 113}, {"text": "Stat3", "start": 125, "end": 130}]}}, "schema": []}
{"input": "MEKs and ERKs inhibited IL-6 activation of Stat3 harboring a mutation at serine-727, the major site for serine phosphorylation, similar to inhibition of wild-type Stat3, and inhibited Janus kinases Jak1 and Jak2 upstream of Stat3 in the Jak-STAT-signaling pathway.", "output": {"entities": {"gene": [{"text": "MEKs", "start": 0, "end": 4}, {"text": "ERKs", "start": 9, "end": 13}, {"text": "IL-6", "start": 24, "end": 28}, {"text": "Stat3", "start": 43, "end": 48}, {"text": "wild-type Stat3", "start": 153, "end": 168}, {"text": "Janus kinases Jak1", "start": 184, "end": 202}, {"text": "Jak2", "start": 207, "end": 211}, {"text": "Stat3", "start": 224, "end": 229}, {"text": "Jak", "start": 237, "end": 240}, {"text": "STAT", "start": 241, "end": 245}]}}, "schema": []}
{"input": "Genome plasticity in the distal tail fiber locus of the T-even bacteriophage: recombination between conserved motifs swaps adhesin specificity.", "output": {"entities": {"gene": [{"text": "adhesin", "start": 123, "end": 130}]}}, "schema": []}
{"input": "Whereas, in the single-chambered body box, PenH units (Enhanced Pause) reflect \" effort of breathing. \" This is measured as the pause between inspiration and expiration.", "output": {"entities": {}}, "schema": []}
{"input": "This suggests that while underpredictions of pain do not hurt more, disruption on primary tasks and physiological impact are higher.", "output": {"entities": {}}, "schema": []}
{"input": "Badcock and Westheimer (Spatial Vision 1 (1), 3-11, 1985) showed that a thin vertical line induces nearby zones of attraction and repulsion; this study extends those results by more closely examining the horizontal and vertical extents of the repulsion zone and by using an illusory contour to induce repulsion.", "output": {"entities": {}}, "schema": []}
{"input": "desmethyltrimebutine was inactive.", "output": {"entities": {}}, "schema": []}
{"input": "A 5. 0-kb transcript detected by the differential display amplicon 3G1 was found to correlate strongly with RAG1 mRNA expression in various human cell lines.", "output": {"entities": {"gene": [{"text": "RAG1 mRNA", "start": 108, "end": 117}]}}, "schema": []}
{"input": "The hBRAG gene was localized to the long arm of chromosome 10 (10q26).", "output": {"entities": {"gene": [{"text": "hBRAG gene", "start": 4, "end": 14}]}}, "schema": []}
{"input": "Genomic locus of chCTCF contains a GC-rich untranslated exon separated from seven coding exons by a long intron.", "output": {"entities": {"gene": [{"text": "chCTCF", "start": 17, "end": 23}]}}, "schema": []}
{"input": "Small GTPases of the Ypt/Rab family are involved in the regulation of vesicular transport.", "output": {"entities": {"gene": [{"text": "Small GTPases", "start": 0, "end": 13}, {"text": "Ypt", "start": 21, "end": 24}, {"text": "Rab", "start": 25, "end": 28}]}}, "schema": []}
{"input": "The GEF and GAP activities for Ypt1p localize to particulate cellular fractions.", "output": {"entities": {"gene": [{"text": "GEF", "start": 4, "end": 7}, {"text": "GAP", "start": 12, "end": 15}, {"text": "Ypt1p", "start": 31, "end": 36}]}}, "schema": []}
{"input": "Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to noradrenaline and is selectively expressed in noradrenergic and adrenergic neurons and neuroendocrine cells.", "output": {"entities": {"gene": [{"text": "Dopamine beta-hydroxylase", "start": 0, "end": 25}, {"text": "DBH", "start": 27, "end": 30}]}}, "schema": []}
{"input": "Collectively, this study emphasizes a critical role of Phox2a as well as its functional synergism with other transcription factors (e. g., CREB, AP2, and Sp1) in transcriptional activation of the DBH gene.", "output": {"entities": {"gene": [{"text": "Phox2a", "start": 55, "end": 61}, {"text": "CREB", "start": 139, "end": 143}, {"text": "AP2", "start": 145, "end": 148}, {"text": "Sp1", "start": 154, "end": 157}, {"text": "DBH gene", "start": 196, "end": 204}]}}, "schema": []}
{"input": "Sequence comparisons strongly suggest that the S27a and the ubiquitin coding sequences found in the genome of CP Rit were both derived from a bovine mRNA encoding a hybrid protein with the structure NH2-ubiquitin-S27a-COOH.", "output": {"entities": {"gene": [{"text": "S27a", "start": 47, "end": 51}, {"text": "ubiquitin", "start": 60, "end": 69}, {"text": "ubiquitin", "start": 203, "end": 212}, {"text": "S27a", "start": 213, "end": 217}]}}, "schema": []}
{"input": "J.", "output": {"entities": {}}, "schema": []}
{"input": "There was a trend in all studies favouring PVI.", "output": {"entities": {}}, "schema": []}
{"input": "This domain, although adjacent to the 5' edge of the SD sequence, does not inhibit ribosome binding as long as the single-stranded region of domain 3 is present.", "output": {"entities": {}}, "schema": []}
{"input": "Previous genetic studies led to the conclusion that nitrate and nitrite induction of nasF operon expression is determined by a transcriptional antitermination mechanism.", "output": {"entities": {"gene": [{"text": "nasF operon", "start": 85, "end": 96}]}}, "schema": []}
{"input": "EGFR levels were found to be elevated 5-, 3.", "output": {"entities": {"gene": [{"text": "EGFR", "start": 0, "end": 4}]}}, "schema": []}
{"input": "Furthermore, LB1 gene mapped to chromosome 13q14, a region that has been involved as a chromosomal breakpoint in DLBL.", "output": {"entities": {"gene": [{"text": "LB1 gene", "start": 13, "end": 21}]}}, "schema": []}
{"input": "Wild-type AT1A receptors, expressed in Chinese hamster ovary cells, rapidly internalized after Ang II stimulation [t1/2 2. 3 min; maximal level of internalization (Ymax) 78. 2%], as did mutant receptors carrying single acidic substitutions (T332E, t1/2 2. 7 min, Ymax 76. 3%; S335D, t1/2 2. 4 min, Ymax 76. 7%; T336E, t1/2 2. 5 min, Ymax 78. 2%; S338D, t1/2 2. 6 min, Ymax 78. 4%).", "output": {"entities": {"gene": [{"text": "Wild-type AT1A receptors", "start": 0, "end": 24}, {"text": "Ang II", "start": 95, "end": 101}]}}, "schema": []}
{"input": "The activated glucocorticoid receptor forms a complex with Stat5 and enhances Stat5-mediated transcriptional induction.", "output": {"entities": {"gene": [{"text": "glucocorticoid receptor", "start": 14, "end": 37}, {"text": "Stat5", "start": 59, "end": 64}, {"text": "Stat5", "start": 78, "end": 83}]}}, "schema": []}
{"input": "T., Mahasneh, A., and Cote, G.", "output": {"entities": {}}, "schema": []}
{"input": "RESULTS: The binding of 99mTc d, 1-HMPAO to human placenta ranged from 2. 95% +/-1. 5% to 5. 82% +/-0. 3% per 1 ml standard solution.", "output": {"entities": {}}, "schema": []}
{"input": "CM reduced the nuclear binding activity of transcription factor AP-1.", "output": {"entities": {"gene": [{"text": "transcription factor AP-1", "start": 43, "end": 68}]}}, "schema": []}
{"input": "NF-kappaB, which is probably important for basal activity of the human NOS II promoter, is unlikely to function as a major effector of CM in DLD-1 cells.", "output": {"entities": {"gene": [{"text": "NF-kappaB", "start": 0, "end": 9}, {"text": "human NOS II promoter", "start": 65, "end": 86}]}}, "schema": []}
{"input": "RESULTS: The cardiac index significantly changed with varying PaCO2 levels (hypocapnia,-9%; hypercapnia, 13%).", "output": {"entities": {}}, "schema": []}
{"input": "Sequencing of a 40-kb DNA segment of the FK506 gene cluster from Streptomyces sp.", "output": {"entities": {}}, "schema": []}
{"input": "The predicted domain structures of FkbB and FkbC are analogous to that of FkbA and comprise 30 fatty-acid-synthase (FAS)-like domains arranged in 6 modules.", "output": {"entities": {"gene": [{"text": "FkbB", "start": 35, "end": 39}, {"text": "FkbC", "start": 44, "end": 48}, {"text": "FkbA", "start": 74, "end": 78}, {"text": "fatty-acid-synthase", "start": 95, "end": 114}, {"text": "FAS", "start": 116, "end": 119}]}}, "schema": []}
{"input": "The cwg2-1 mutation was identified as a guanine to adenine substitution at nucleotide 604 of the coding region, originating the change A202T in the cwg2p.", "output": {"entities": {"gene": [{"text": "cwg2-1 mutation", "start": 4, "end": 19}, {"text": "cwg2p", "start": 148, "end": 153}]}}, "schema": []}
{"input": "Handling on PND 9 did not result in elevated CORT levels in any of the groups.", "output": {"entities": {}}, "schema": []}
{"input": "633 +/-258 aggregates/ml at 0 rpm; P < 0. 001).", "output": {"entities": {}}, "schema": []}
{"input": "These results indicate that the total number of subunit c in F0 should be a multiple of 2 and 3.", "output": {"entities": {"gene": [{"text": "F0", "start": 61, "end": 63}]}}, "schema": []}
{"input": "BACKGROUND: The c-myc proto-oncogene has been suggested to play key roles in cell proliferation, differentiation, transformation and apoptosis.", "output": {"entities": {"gene": [{"text": "c-myc proto-oncogene", "start": 16, "end": 36}]}}, "schema": []}
{"input": "AMY-1 was localized in the cytoplasm in cells expressing c-myc at low levels, but in the nucleus in the cells of a high c-myc expression in transiently transfected cells.", "output": {"entities": {"gene": [{"text": "AMY-1", "start": 0, "end": 5}, {"text": "c-myc", "start": 57, "end": 62}, {"text": "c-myc", "start": 120, "end": 125}]}}, "schema": []}
{"input": "Antidepressant-like properties of some serotonin receptor ligands and calcium channel antagonists measured with the forced swimming test in mice.", "output": {"entities": {"gene": [{"text": "serotonin receptor", "start": 39, "end": 57}]}}, "schema": []}
{"input": "The various available data strongly suggesting an environmental toxic origin for the \" sperm fall \" will be presented as well as the most frequently suspected class of substances, the xenoestrogens.", "output": {"entities": {}}, "schema": []}
{"input": "Examination of DNA: protein binding complexes by gel-shift analysis indicated that nuclear factors from both proliferative and growth-arrested cells bound to the DNA fragment spanning-949--722 bp.", "output": {"entities": {}}, "schema": []}
{"input": "RESULTS: An herpetic seroconversion is observed with presence of type I herpes simplex virus (HSV I) nucleic acids in the recipient' s aqueous humor.", "output": {"entities": {}}, "schema": []}
{"input": "GH failed to stimulate phosphorylation or activation of Jun N-terminal kinase under the conditions used.", "output": {"entities": {"gene": [{"text": "GH", "start": 0, "end": 2}, {"text": "Jun N-terminal kinase", "start": 56, "end": 77}]}}, "schema": []}
{"input": "CD4 lymphocyte and viral load levels suggested an optimal response to ARV therapy at the time LD developed.", "output": {"entities": {"gene": [{"text": "CD4", "start": 0, "end": 3}]}}, "schema": []}
{"input": "By DNase I footprint analysis of the PNR element, a palindrome of two high-affinity Ets-binding sites (CTTCCCTGGAAG) was identified.", "output": {"entities": {"gene": [{"text": "DNase I", "start": 3, "end": 10}, {"text": "Ets-binding sites", "start": 84, "end": 101}]}}, "schema": []}
{"input": "No mutations were found in follicular adenomas.", "output": {"entities": {}}, "schema": []}
{"input": "Expression of lacZ from the promoter of the Escherichia coli spc operon cloned into vectors carrying the W205 trp-lac fusion.", "output": {"entities": {"gene": [{"text": "lacZ", "start": 14, "end": 18}, {"text": "Escherichia coli spc operon", "start": 44, "end": 71}, {"text": "trp", "start": 110, "end": 113}, {"text": "lac", "start": 114, "end": 117}]}}, "schema": []}
{"input": "RT-PCR analysis showed that PLP-H as well as PLP-C and PLP-D are expressed in all rat strains examined, confirming that PLP diversity is not due to strain differences.", "output": {"entities": {"gene": [{"text": "PLP-H", "start": 28, "end": 33}, {"text": "PLP-C", "start": 45, "end": 50}, {"text": "PLP-D", "start": 55, "end": 60}, {"text": "PLP", "start": 120, "end": 123}]}}, "schema": []}
{"input": "Molecular cloning and characterization of a new member of the rat placental prolactin (PRL) family, PRL-like protein H.", "output": {"entities": {"gene": [{"text": "rat placental prolactin", "start": 62, "end": 85}, {"text": "PRL", "start": 87, "end": 90}, {"text": "PRL", "start": 100, "end": 103}, {"text": "protein H", "start": 109, "end": 118}]}}, "schema": []}
{"input": "Thus, we have identified an activation target of a human activator, Oct-1, within its cognate basal transcription complex.", "output": {"entities": {"gene": [{"text": "Oct-1", "start": 68, "end": 73}]}}, "schema": []}
{"input": "The results raise the possibility that pH induced post-translational modifications of DdRPA are involved in events that halt cell proliferation and induce differentiation in Dictyostelium.", "output": {"entities": {"gene": [{"text": "DdRPA", "start": 86, "end": 91}]}}, "schema": []}
{"input": "P-CIP1, a novel protein that interacts with the cytosolic domain of peptidylglycine alpha-amidating monooxygenase, is associated with endosomes.", "output": {"entities": {"gene": [{"text": "P-CIP1", "start": 0, "end": 6}, {"text": "peptidylglycine alpha-amidating monooxygenase", "start": 68, "end": 113}]}}, "schema": []}
{"input": "In this study we provide evidence that B-Myb is a direct physiological target for cyclin A/Cdk2.", "output": {"entities": {"gene": [{"text": "B-Myb", "start": 39, "end": 44}, {"text": "cyclin A", "start": 82, "end": 90}, {"text": "Cdk2", "start": 91, "end": 95}]}}, "schema": []}
{"input": "The highly amyloidogenic 42-residue form of Abeta (Abeta42) is the first species to be deposited in both sporadic and familial AD.", "output": {"entities": {"gene": [{"text": "Abeta", "start": 44, "end": 49}, {"text": "Abeta42", "start": 51, "end": 58}]}}, "schema": []}
{"input": "This model is supported by experiments showing that Cdr2 associates with the N-terminal regulatory domain of Wee1 in cell lysates and phosphorylates Wee1 in vitro.", "output": {"entities": {"gene": [{"text": "Cdr2", "start": 52, "end": 56}, {"text": "N-terminal regulatory domain of Wee1", "start": 77, "end": 113}, {"text": "Wee1", "start": 149, "end": 153}]}}, "schema": []}
{"input": "RESULTS: Significant changes from pretreatment to posttreatment were observed (p < 0. 001).", "output": {"entities": {}}, "schema": []}
{"input": "The tip of the button caused a perforation of the posterior stomach wall, leading to death.", "output": {"entities": {}}, "schema": []}
{"input": "Also, the amplitude of the oscillatory potentials (O1 + O2 + O3 + O4) was significantly reduced in the early postoperative period.", "output": {"entities": {}}, "schema": []}
{"input": "Both NUP98-HOXA9 chimeras transformed NIH 3T3 fibroblasts, and this transformation required the HOXA9 domains for DNA binding and PBX interaction.", "output": {"entities": {"gene": [{"text": "NUP98", "start": 5, "end": 10}, {"text": "HOXA9", "start": 11, "end": 16}, {"text": "HOXA9 domains", "start": 96, "end": 109}, {"text": "PBX", "start": 130, "end": 133}]}}, "schema": []}
{"input": "Ethylene is involved in endosperm rupture and high-level betaGLU I expression; but, it does not affect the spatial and temporal pattern of betaGLU I expression.", "output": {"entities": {"gene": [{"text": "betaGLU I", "start": 57, "end": 66}, {"text": "betaGLU I", "start": 139, "end": 148}]}}, "schema": []}
{"input": "The divergence in primary structure between the sheep CRF1 and the other mammalian CRF1s is primarily localized to the extracellular amino terminal domain of the receptor (18 of 22 divergent residues, ovine vs human CRF1).", "output": {"entities": {"gene": [{"text": "CRF1", "start": 54, "end": 58}, {"text": "mammalian CRF1s", "start": 73, "end": 88}, {"text": "human CRF1", "start": 210, "end": 220}]}}, "schema": []}
{"input": "Agonist-induced receptor internalization, determined as the percent of total [125I] Tyr0-oCRF bound located in the acid-resistant fraction of transfected Cos 7 cells, increased with time (0-60 min at 37 degrees C) for both wild-type and variant oCRF1.", "output": {"entities": {"gene": [{"text": "Tyr0-oCRF", "start": 84, "end": 93}, {"text": "oCRF1", "start": 245, "end": 250}]}}, "schema": []}
{"input": "This c-Jun activity is inhibited by c-Fos, another protooncoprotein that can dimerize with c-Jun to form the transcription factor AP-1.", "output": {"entities": {"gene": [{"text": "c-Jun", "start": 5, "end": 10}, {"text": "c-Fos", "start": 36, "end": 41}, {"text": "c-Jun", "start": 91, "end": 96}, {"text": "AP-1", "start": 130, "end": 134}]}}, "schema": []}
{"input": "CONCLUSION: Our study shows that (1) total body BMD and femoral neck BMD were significantly higher in the study group that performed weight-bearing exercises than in control subjects, (2) swimming exercise had no effect on BMD, and (3) although swimming is not a bone-building exercise, it can significantly improve shoulder, back, and grip muscle strength.", "output": {"entities": {}}, "schema": []}
{"input": "Comparisons with other known germins and germin-like proteins indicate that these Arabidopsis GLP subfamilies are unique from wheat germin.", "output": {"entities": {"gene": [{"text": "germins", "start": 29, "end": 36}, {"text": "germin-like proteins", "start": 41, "end": 61}, {"text": "GLP", "start": 94, "end": 97}, {"text": "germin", "start": 132, "end": 138}]}}, "schema": []}
{"input": "However, there has not been any evidence of A. salmonicida infections, specifically furunculosis, associated with the fish in this loch.", "output": {"entities": {}}, "schema": []}
{"input": "Improving the evidence base for anaesthesia.", "output": {"entities": {}}, "schema": []}
{"input": "Plasma CCK levels were determined at regular intervals.", "output": {"entities": {"gene": [{"text": "CCK", "start": 7, "end": 10}]}}, "schema": []}
{"input": "Consistent with these findings, relatively weak transcriptional silencing by the native VDR was observed using the osteopontin VDRE.", "output": {"entities": {"gene": [{"text": "VDR", "start": 88, "end": 91}, {"text": "osteopontin", "start": 115, "end": 126}]}}, "schema": []}
{"input": "A motif (TGATGTCA) which matches a CREB site and is similar to an AP-1 site is embedded within ER2.", "output": {"entities": {"gene": [{"text": "CREB site", "start": 35, "end": 44}, {"text": "AP-1 site", "start": 66, "end": 75}, {"text": "ER2", "start": 95, "end": 98}]}}, "schema": []}
{"input": "Conventionally, four nominal allotypic variants, b4, b5, b6 and b9 have been shown to be co-dominantly expressed at the Ckappa1 gene locus.", "output": {"entities": {"gene": [{"text": "Ckappa1 gene locus", "start": 120, "end": 138}]}}, "schema": []}
{"input": "Therefore, in order to search for the latent genes, we used allotype-specific oligonucleotides for b5, b6 and b9 to probe DNAs from both normal and T. brucei-infected rabbits by Southern blotting.", "output": {"entities": {}}, "schema": []}
{"input": "TRAF2 is known to associate with TRADD, and expression of a dominant-negative N-terminal deletion TRAF2 mutant was found to partially inhibit LMP1-induced JNK activation in 293 cells.", "output": {"entities": {"gene": [{"text": "TRAF2", "start": 0, "end": 5}, {"text": "TRADD", "start": 33, "end": 38}, {"text": "TRAF2 mutant", "start": 98, "end": 110}, {"text": "LMP1", "start": 142, "end": 146}, {"text": "JNK", "start": 155, "end": 158}]}}, "schema": []}
{"input": "These data further define a role for TRADD and TRAF2 in JNK activation and confirm that LMP1 utilizes signalling mechanisms used by the TNF receptor/CD40 family to elicit its pleiotropic activities.", "output": {"entities": {"gene": [{"text": "TRADD", "start": 37, "end": 42}, {"text": "TRAF2", "start": 47, "end": 52}, {"text": "JNK", "start": 56, "end": 59}, {"text": "LMP1", "start": 88, "end": 92}, {"text": "TNF receptor", "start": 136, "end": 148}, {"text": "CD40", "start": 149, "end": 153}]}}, "schema": []}
{"input": "Epstein-Barr virus-encoded latent membrane protein 1 activates the JNK pathway through its extreme C terminus via a mechanism involving TRADD and TRAF2.", "output": {"entities": {"gene": [{"text": "Epstein-Barr virus-encoded latent membrane protein 1", "start": 0, "end": 52}, {"text": "JNK", "start": 67, "end": 70}, {"text": "TRADD", "start": 136, "end": 141}, {"text": "TRAF2", "start": 146, "end": 151}]}}, "schema": []}
{"input": "In contrast, transiently transfected cells expressing EBNA-3 revealed a sixfold increase in EBNA-3 protein expression from the genomic EBNA-3 gene compared to EBNA-3 cDNA.", "output": {"entities": {"gene": [{"text": "EBNA-3", "start": 54, "end": 60}, {"text": "EBNA-3 protein", "start": 92, "end": 106}, {"text": "EBNA-3 gene", "start": 135, "end": 146}, {"text": "EBNA-3 cDNA", "start": 159, "end": 170}]}}, "schema": []}
{"input": "However, serial passages of fetal lamb kidney (FLK) cells, which are sensitive to infection with BLV, after transient transfection revealed that mutation of a second tyrosine residue in the N-terminal motif completely prevented the propagation of the virus.", "output": {"entities": {}}, "schema": []}
{"input": "To search for transcriptional regulators, we used a fragment of the SpHE promoter containing several individual elements instead of the conventional bait that contains a multimerized cis element.", "output": {"entities": {"gene": [{"text": "SpHE promoter", "start": 68, "end": 81}]}}, "schema": []}
{"input": "As expected for a positive SpHE transcriptional regulator, the timing of SpEts4 gene expression precedes the transient expression of SpHE in the very early sea urchin blastula.", "output": {"entities": {"gene": [{"text": "SpHE transcriptional regulator", "start": 27, "end": 57}, {"text": "SpEts4 gene", "start": 73, "end": 84}, {"text": "SpHE", "start": 133, "end": 137}]}}, "schema": []}
{"input": "Induction of anaesthesia was standardised: fentanyl (3 micrograms/kg), thiopentone (5 mg/kg), atracurium (0. 4 mg/kg).", "output": {"entities": {}}, "schema": []}
{"input": "Conserved and distinct roles of kreisler in regulation of the paralogous Hoxa3 and Hoxb3 genes.", "output": {"entities": {"gene": [{"text": "kreisler", "start": 32, "end": 40}, {"text": "Hoxa3", "start": 73, "end": 78}, {"text": "Hoxb3 genes", "start": 83, "end": 94}]}}, "schema": []}
{"input": "Moreover, this enhancement of transcriptional activation by COUP-TFI requires specifically the AF-1 transactivation function of ER and can be observed in the presence of E2 or 4-hydroxytamoxifen but not ICI 164384.", "output": {"entities": {"gene": [{"text": "COUP-TFI", "start": 60, "end": 68}, {"text": "ER", "start": 128, "end": 130}]}}, "schema": []}
{"input": "Recombinant Ffh has a melting point of tm = 89 degreesC.", "output": {"entities": {"gene": [{"text": "Recombinant Ffh", "start": 0, "end": 15}]}}, "schema": []}
{"input": "This region of hsp90 mediates ATP-independent chaperone activity, overlaps the hsp90 dimerization domain, and includes structural elements important for steroid receptor interaction.", "output": {"entities": {"gene": [{"text": "hsp90", "start": 15, "end": 20}, {"text": "hsp90 dimerization domain", "start": 79, "end": 104}, {"text": "steroid receptor", "start": 153, "end": 169}]}}, "schema": []}
{"input": "The RNA polymerase III-recruiting factor TFIIIB induces a DNA bend between the TATA box and the transcriptional start site.", "output": {"entities": {"gene": [{"text": "RNA polymerase III-recruiting factor TFIIIB", "start": 4, "end": 47}]}}, "schema": []}
{"input": "Analysis of hematopoietic growth factor prescriptions in 19 french cancer centers", "output": {"entities": {"gene": [{"text": "hematopoietic growth factor", "start": 12, "end": 39}]}}, "schema": []}
{"input": "Chem.", "output": {"entities": {}}, "schema": []}
{"input": "These results suggest that the c-met gene is also a target of p53 gene regulation.", "output": {"entities": {"gene": [{"text": "c-met gene", "start": 31, "end": 41}, {"text": "p53 gene", "start": 62, "end": 70}]}}, "schema": []}
{"input": "Pokeweed antiviral protein (PAP) from Phytolacca americana is a highly specific N-glycosidase removing adenine residues (A4324 in 28S rRNA and A2660 in 23S rRNA) from intact ribosomes of both eukaryotes and prokaryotes.", "output": {"entities": {"gene": [{"text": "Pokeweed antiviral protein", "start": 0, "end": 26}, {"text": "PAP", "start": 28, "end": 31}, {"text": "N-glycosidase", "start": 80, "end": 93}, {"text": "28S rRNA", "start": 130, "end": 138}, {"text": "23S rRNA", "start": 152, "end": 160}]}}, "schema": []}
{"input": "Among these 360 ZFPs, a novel ZFP cDNA named HFHZ (human fetal heart ZFP) with sequence homology to a Kruppel-associated box (KRAB) was identified.", "output": {"entities": {"gene": [{"text": "ZFPs", "start": 16, "end": 20}, {"text": "ZFP cDNA", "start": 30, "end": 38}, {"text": "HFHZ", "start": 45, "end": 49}, {"text": "human fetal heart ZFP", "start": 51, "end": 72}, {"text": "Kruppel-associated box", "start": 102, "end": 124}, {"text": "KRAB", "start": 126, "end": 130}]}}, "schema": []}
{"input": "The 3. 3-fold higher expression in the fetal heart than in the adult heart suggests that HFHZ mRNA is downregulated in the process of development.", "output": {"entities": {"gene": [{"text": "HFHZ mRNA", "start": 89, "end": 98}]}}, "schema": []}
{"input": "CONTEXT: ThinPrep, AutoPap, and Papnet are 3 new technologies that increase the sensitivity and cost of cervical cancer screening.", "output": {"entities": {}}, "schema": []}
{"input": "Experiments on narcotized cats demonstrated that the derivatives of 2-mercaptobenzimidazole possessing the properties of specific bradycardic agents and coded as CM-251, CM-266, and CM-345, reduce the mean rise of segment ST on numerous leads of the epicardial electrogram during 5-min occlusion of the anterior descending branch of the left coronary artery.", "output": {"entities": {}}, "schema": []}
{"input": "Expression of the second gene (XT3) was found to be conserved in human kidney, and partial sequence was obtained from a human cDNA library.", "output": {"entities": {"gene": [{"text": "XT3", "start": 31, "end": 34}]}}, "schema": []}
{"input": "Internal modes of a soliton.", "output": {"entities": {}}, "schema": []}
{"input": "(2) Erythroid 32D Epo1 cells showed a lower level of bulk PKC catalytic activity, lacked the expression of epsilon and eta PKC isoforms, and showed a weak or absent upregulation of the remaining isoforms, except betaI, upon readdition of Epo to growth factor-starved cells.", "output": {"entities": {"gene": [{"text": "Epo1", "start": 18, "end": 22}, {"text": "PKC", "start": 58, "end": 61}, {"text": "epsilon and eta PKC isoforms", "start": 107, "end": 135}, {"text": "betaI", "start": 212, "end": 217}, {"text": "Epo", "start": 238, "end": 241}]}}, "schema": []}
{"input": "We used expression cloning to identify interleukin-6 (IL-6) as one factor that suppressed growth of a pre-B-cell variant line, 1A9-M.", "output": {"entities": {"gene": [{"text": "interleukin-6", "start": 39, "end": 52}, {"text": "IL-6", "start": 54, "end": 58}]}}, "schema": []}
{"input": "Airflow through the dust trap was controlled with a vacuum pump.", "output": {"entities": {}}, "schema": []}
{"input": "Several mutations disrupted the endonuclease and helicase activities; however, only one amino-terminal-charge cluster mutant protein (D40A-D42A-D44A) completely lost AAV hairpin DNA binding activity.", "output": {"entities": {"gene": [{"text": "helicase", "start": 49, "end": 57}, {"text": "amino-terminal-charge cluster mutant protein", "start": 88, "end": 132}]}}, "schema": []}
{"input": "Here we describe the identification and characterization of several Sp100 splice variant proteins and support their existence by elucidation of the 3'-end of the Sp100 gene.", "output": {"entities": {"gene": [{"text": "Sp100 splice variant proteins", "start": 68, "end": 97}, {"text": "Sp100 gene", "start": 162, "end": 172}]}}, "schema": []}
{"input": "It was demonstrated that the processing signals in the transcript, i. e. both donor splice sites and the polyadenylation site located in the muscle-specific intron, have to be weak.", "output": {"entities": {}}, "schema": []}
{"input": "Chirality-glass and spin-glass correlations in the two-dimensional random-bond XY model.", "output": {"entities": {}}, "schema": []}
{"input": "Echo modulation in Pr3 +: YAlO3.", "output": {"entities": {}}, "schema": []}
{"input": "Mechanisms of visible-light emission from electro-oxidized porous silicon.", "output": {"entities": {}}, "schema": []}
{"input": "Optically detected librons and phonons in crystalline C60.", "output": {"entities": {}}, "schema": []}
{"input": "Factors influencing direct-immersion (DI)-SPME process were also checked and chosen experimentally.", "output": {"entities": {}}, "schema": []}
{"input": "In contrast, an amino-terminal fragment containing the C/H1 domain was sufficient for coactivation of Zta transcription and viral reactivation function.", "output": {"entities": {"gene": [{"text": "Zta", "start": 102, "end": 105}]}}, "schema": []}
{"input": "In addition, a potent splicing enhancer sequence isolated in the selection specifically binds a 20-kDa SR protein.", "output": {"entities": {"gene": [{"text": "20-kDa SR protein", "start": 96, "end": 113}]}}, "schema": []}
{"input": "These data suggest that other Ras effectors can collaborate with PI 3-kinase and with each other to activate Pak.", "output": {"entities": {"gene": [{"text": "Ras effectors", "start": 30, "end": 43}, {"text": "PI 3-kinase", "start": 65, "end": 76}, {"text": "Pak", "start": 109, "end": 112}]}}, "schema": []}
{"input": "Electrophoretic mobility-shift assays performed with the HNF-3 X and Y sites demonstrated that both sites are capable of binding HNF-3alpha and HNF-3beta.", "output": {"entities": {"gene": [{"text": "HNF-3", "start": 57, "end": 62}, {"text": "HNF-3alpha", "start": 129, "end": 139}, {"text": "HNF-3beta", "start": 144, "end": 153}]}}, "schema": []}
{"input": "Proteins known to bind the PEPCK CRE include the CRE-binding protein (CREB) and members of the CCAAT/enhancer-binding protein (C/EBP) family.", "output": {"entities": {"gene": [{"text": "PEPCK", "start": 27, "end": 32}, {"text": "CRE-binding protein", "start": 49, "end": 68}, {"text": "CREB", "start": 70, "end": 74}, {"text": "CCAAT/enhancer-binding protein", "start": 95, "end": 125}, {"text": "C/EBP", "start": 127, "end": 132}]}}, "schema": []}
{"input": "This construct, termed pDeltaCREC/EBP, binds C/EBPalpha and beta but not CREB, yet it confers a nearly complete glucocorticoid response when transiently transfected into H4IIE rat hepatoma cells.", "output": {"entities": {"gene": [{"text": "pDeltaCREC", "start": 23, "end": 33}, {"text": "EBP", "start": 34, "end": 37}, {"text": "C/EBPalpha and beta", "start": 45, "end": 64}, {"text": "CREB", "start": 73, "end": 77}]}}, "schema": []}
{"input": "Systematic functional analysis of V1a/V2 hybrid receptors showed that the second intracellular loop of the V1a receptor is required and sufficient for efficient coupling to Gq/11, whereas the third intracellular loop of the V2 receptor is required and sufficient for coupling to Gs.", "output": {"entities": {"gene": [{"text": "V1a/V2 hybrid receptors", "start": 34, "end": 57}, {"text": "V1a receptor", "start": 107, "end": 119}, {"text": "Gq/11", "start": 173, "end": 178}, {"text": "V2 receptor", "start": 224, "end": 235}, {"text": "Gs", "start": 279, "end": 281}]}}, "schema": []}
{"input": "The fatigue exercise showed relatively high blood lactate concentration [12. 5 (SD 2. 6) mmol x l (-1)] and an increase of serum creatine kinase (CK) activity delayed by 2 days [540 (SD 407) U x l (-1)].", "output": {"entities": {"gene": [{"text": "serum creatine kinase", "start": 123, "end": 144}, {"text": "CK", "start": 146, "end": 148}]}}, "schema": []}
{"input": "New Langevin equations for a translating and simultaneously rotating asymmetric top.", "output": {"entities": {}}, "schema": []}
{"input": "In the brain, muscarinic receptors mediate motor and memory function by interaction with their ligand acetylcholine.", "output": {"entities": {"gene": [{"text": "muscarinic receptors", "start": 14, "end": 34}]}}, "schema": []}
{"input": "In this study, we investigated the signal transduction pathways that are involved in OM-induced LDLR transcription.", "output": {"entities": {"gene": [{"text": "OM", "start": 85, "end": 87}, {"text": "LDLR", "start": 96, "end": 100}]}}, "schema": []}
{"input": "The Lp mouse mutant provides a model for the severe human neural tube defect (NTD), cranio-rachischisis.", "output": {"entities": {"gene": [{"text": "Lp mouse mutant", "start": 4, "end": 19}]}}, "schema": []}
{"input": "Therefore, high set-up accuracy and reproducibility are mandatory.", "output": {"entities": {}}, "schema": []}
{"input": "CPDs at these three sites may partially displace TFIIIA, thereby enabling rapid repair.", "output": {"entities": {"gene": [{"text": "TFIIIA", "start": 49, "end": 55}]}}, "schema": []}
{"input": "There was no difference in the hormone receptor status between the cases without lymph node metastases and with lymph node metastases,' clandestine' or macrometastases.", "output": {"entities": {}}, "schema": []}
{"input": "Gel filtration, sedimentation velocity, and immunoprecipitation experiments revealed that beta4 is a component of a multisubunit complex (AP-4) that also contains the sigma4 polypeptide and two additional adaptor subunit homologs named mu4 (mu-ARP2) and epsilon.", "output": {"entities": {"gene": [{"text": "AP-4", "start": 138, "end": 142}]}}, "schema": []}
{"input": "We show that the mouse genome contains four copies of the ubc-9 gene.", "output": {"entities": {"gene": [{"text": "ubc-9 gene", "start": 58, "end": 68}]}}, "schema": []}
{"input": "Independent splicing events involve three previously described cassette exons, which are predicted to encode most of the second transmembrane domain.", "output": {"entities": {}}, "schema": []}
{"input": "Each of these genes contains a putative upstream ORF, while STA2 has two additional in-frame AUG codons 5' to the major cistron.", "output": {"entities": {"gene": [{"text": "STA2", "start": 60, "end": 64}]}}, "schema": []}
{"input": "Primary and secondary structural elements required for synthesis of barley yellow dwarf virus subgenomic RNA1.", "output": {"entities": {}}, "schema": []}
{"input": "The H-reflex recovery curve was obtained after stimulation of the median nerve at the elbow and recording from the flexor carpi radialis.", "output": {"entities": {}}, "schema": []}
{"input": "To identify additional non-Sir factors that affect rDNA silencing, we performed a genetic screen designed to isolate mutations which alter the expression of reporter genes integrated within the rDNA.", "output": {"entities": {"gene": [{"text": "Sir factors", "start": 27, "end": 38}]}}, "schema": []}
{"input": "In this study, we elucidate signaling pathways induced by photodynamic therapy (PDT) with hypericin.", "output": {"entities": {}}, "schema": []}
{"input": "These results indicate that ATF-2 plays a central role in TGF-beta signaling by acting as a common nuclear target of both Smad and TAK1 pathways.", "output": {"entities": {"gene": [{"text": "ATF-2", "start": 28, "end": 33}, {"text": "TGF-beta", "start": 58, "end": 66}, {"text": "Smad", "start": 122, "end": 126}, {"text": "TAK1", "start": 131, "end": 135}]}}, "schema": []}
{"input": "FASEB Federal Funding Consensus Conference FY 2000.", "output": {"entities": {}}, "schema": []}
{"input": "Analysis of the protein sequences of these two replicases, together with previously characterized H. pylori plasmid replication proteins, supports the formation of a distinct class of H. pylori plasmid proteins.", "output": {"entities": {"gene": [{"text": "replicases", "start": 47, "end": 57}, {"text": "H. pylori plasmid replication proteins", "start": 98, "end": 136}, {"text": "H. pylori plasmid proteins", "start": 184, "end": 210}]}}, "schema": []}
{"input": "The algorithm also limited TG to 20 and 64%, apoB to 6 and 20%, and Lp (a) to 15 and 56%, of low-and high-risk groups, respectively.", "output": {"entities": {"gene": [{"text": "apoB", "start": 45, "end": 49}, {"text": "Lp (a)", "start": 68, "end": 74}]}}, "schema": []}
{"input": "Conformational studies combining secondary structure predictions, CD and NMR spectroscopy together with ELISA assays, showed that the greater is the propensity of the epitope for helix formation the higher is the recognition by anti-K159.", "output": {"entities": {"gene": [{"text": "anti-K159", "start": 228, "end": 237}]}}, "schema": []}
{"input": "Schwab and England ADL scores in the \" off \" state were improved by 18% and in the \" on \" state the scores declined by 2%.", "output": {"entities": {}}, "schema": []}
{"input": "Sequence analysis revealed that the MEMA protein is identical with a 160 kDa nuclear' domain rich in serines' (DRS) protein occurring free in the nucleoplasm and in U2-ribonucleoprotein structures.", "output": {"entities": {"gene": [{"text": "MEMA protein", "start": 36, "end": 48}, {"text": "160 kDa nuclear' domain rich in serines' (DRS) protein", "start": 69, "end": 123}, {"text": "U2-ribonucleoprotein structures", "start": 165, "end": 196}]}}, "schema": []}
{"input": "Dopaminergic modulation of transcallosal activity of cat motor cortical neurons.", "output": {"entities": {}}, "schema": []}
{"input": "The induced respiratory burst was investigated by the intracellular oxidative transformation of dihydrorhodamine 123 to the fluorescent dye rhodamine 123 via flow cytometry.", "output": {"entities": {}}, "schema": []}
{"input": "JCAHO asks for hospitals' patience.", "output": {"entities": {}}, "schema": []}
{"input": "25-OH-D3 did not adversely affect animal health at the proposed use level of 99 micrograms/kg feed when replacing vitamin D3 in turkey rations.", "output": {"entities": {}}, "schema": []}
{"input": "As such the findings support existing studies that have identified given social characteristics of drink drivers.", "output": {"entities": {}}, "schema": []}
{"input": "Analysis of lacZ transcriptional fusions shows that the KdgR-binding sites negatively affect the expression of rsmB.", "output": {"entities": {"gene": [{"text": "lacZ transcriptional fusions", "start": 12, "end": 40}, {"text": "KdgR-binding sites", "start": 56, "end": 74}, {"text": "rsmB", "start": 111, "end": 115}]}}, "schema": []}
{"input": "In the cell-free import assay, beta-catenin rapidly migrates into the nucleus without the exogenous addition of cytosol, Ran, or ATP/GTP.", "output": {"entities": {"gene": [{"text": "beta-catenin", "start": 31, "end": 43}, {"text": "Ran", "start": 121, "end": 124}]}}, "schema": []}
{"input": "In ischemic and hypoxic hypoxia, a strong correlation was found between cyt a, a3 oxidation level and VO2 in both ischemic and hypoxic hypoxia (r2 =. 90 and. 87, respectively).", "output": {"entities": {}}, "schema": []}
{"input": "Each recombinant product was a fusion protein with a B domain of Staphylococcal protein A (SPA).", "output": {"entities": {"gene": [{"text": "Staphylococcal protein A", "start": 65, "end": 89}, {"text": "SPA", "start": 91, "end": 94}]}}, "schema": []}
{"input": "Polypyrimidine and ssDNA binding by the isolated VH domain of immunization-induced anti-Z-DNA Ab resembles the activity of natural autoantibodies and suggests that VH-dependent binding to a ligand mimicked by polypyrimidines may play a role in B cell selection before immunization with Z-DNA.", "output": {"entities": {"gene": [{"text": "VH domain", "start": 49, "end": 58}, {"text": "VH", "start": 164, "end": 166}]}}, "schema": []}
{"input": "INTERVENTIONS: Study patients were randomly divided into four parallel groups to receive either terbinafine 250 mg a day for 12 or 16 weeks (groups T12 and T16) or itraconazole 400 mg a day for 1 week in every 4 weeks for 12 or 16 weeks (groups I3 and I4).", "output": {"entities": {}}, "schema": []}
{"input": "Bacteria can also cause a labyrinthitis acting directly on the inner ear: among these, Treponemas Pallidum, a spirochaete which causes syphilis and Borrelia Burgdorferi, a spirochaete that causes Lyme Disease, must be mentioned.", "output": {"entities": {}}, "schema": []}
{"input": "Initial control of bleeding is similar, but eradication is achieved in fewer sessions with EVL.", "output": {"entities": {}}, "schema": []}
{"input": "Canalith repositioning is the mainstay of treatment.", "output": {"entities": {}}, "schema": []}
{"input": "Solution structure and mechanism of the MutT pyrophosphohydrolase.", "output": {"entities": {"gene": [{"text": "MutT pyrophosphohydrolase", "start": 40, "end": 65}]}}, "schema": []}
{"input": "The binding of PH domains to Gbetagamma was inhibited by preincubation of Gbetagamma with the GDP-bound but not the GTP-bound form of Gialpha.", "output": {"entities": {"gene": [{"text": "PH domains", "start": 15, "end": 25}, {"text": "Gbetagamma", "start": 29, "end": 39}, {"text": "Gbetagamma", "start": 74, "end": 84}, {"text": "Gialpha", "start": 134, "end": 141}]}}, "schema": []}
{"input": "Two-dimensional gel electrophoresis of anti-p59fyn immunoprecipitates obtained from non-transformed resting human T lymphocytes resulted in the identification of an oligomeric protein complex which is constitutively formed between Fyn and several additional phosphoproteins (pp43, pp72, pp85, the protein tyrosine kinase Pyk2, as well as the two recently cloned adaptor proteins, SKAP55 and SLAP-130).", "output": {"entities": {"gene": [{"text": "anti-p59fyn", "start": 39, "end": 50}, {"text": "Fyn", "start": 231, "end": 234}, {"text": "pp43", "start": 275, "end": 279}, {"text": "pp72", "start": 281, "end": 285}, {"text": "pp85", "start": 287, "end": 291}, {"text": "protein tyrosine kinase Pyk2", "start": 297, "end": 325}, {"text": "SKAP55", "start": 380, "end": 386}, {"text": "SLAP-130", "start": 391, "end": 399}]}}, "schema": []}
{"input": "The gene structure of Elk1 spans 15. 2 kb and consists of seven exons and six introns.", "output": {"entities": {"gene": [{"text": "Elk1", "start": 22, "end": 26}]}}, "schema": []}
{"input": "Sequence analysis suggests that TtrA contains a molybdopterin guanine dinucleotide cofactor and a [4Fe-4S] cluster, that TtrB binds four [4Fe-4S] clusters, and that TtrC is an integral membrane protein containing a quinol oxidation site.", "output": {"entities": {"gene": [{"text": "TtrA", "start": 32, "end": 36}, {"text": "TtrB", "start": 121, "end": 125}, {"text": "TtrC", "start": 165, "end": 169}]}}, "schema": []}
{"input": "Previous work has shown that spleen necrosis virus (SNV) long terminal repeats (LTRs) are associated with Rex/Rex-responsive element-independent expression of bovine leukemia virus RNA and supports the hypothesis that SNV RNA contains a cis-acting element that interacts with cellular Rex-like proteins.", "output": {"entities": {"gene": [{"text": "spleen necrosis virus (SNV) long terminal repeats", "start": 29, "end": 78}, {"text": "Rex", "start": 106, "end": 109}, {"text": "Rex", "start": 110, "end": 113}, {"text": "cellular Rex-like proteins", "start": 276, "end": 302}]}}, "schema": []}
{"input": "Online LATCH demonstrates a shift in identification of the library as an isolated unit to an interactive resource center.", "output": {"entities": {}}, "schema": []}
{"input": "We calculated differences in late occlusion rates by the chi2 (chi-square) test, and found these differences were significant (P =. 04).", "output": {"entities": {}}, "schema": []}
{"input": "We describe a genetic system for further characterizing the role of the extreme C-terminus of the beta subunit of E. coli RNA polymerase.", "output": {"entities": {"gene": [{"text": "E. coli RNA polymerase", "start": 114, "end": 136}]}}, "schema": []}
{"input": "The enhanced binding of c-Abl to DNA containing 5-methylcytosine residues may result from an increased propensity of the double helix to denature locally coupled with a protein-induced reduction in the base stacking interaction.", "output": {"entities": {"gene": [{"text": "c-Abl", "start": 24, "end": 29}]}}, "schema": []}
{"input": "We further demonstrate that the Stress-Activated-Protein-Kinase (SAPK) target sites of ATF2, Thr69 and Thr71 are not required for the formation of the p300/CBP-ATF2 multiprotein complex.", "output": {"entities": {"gene": [{"text": "Stress-Activated-Protein-Kinase", "start": 32, "end": 63}, {"text": "SAPK", "start": 65, "end": 69}, {"text": "ATF2", "start": 87, "end": 91}, {"text": "p300", "start": 151, "end": 155}, {"text": "CBP", "start": 156, "end": 159}, {"text": "ATF2", "start": 160, "end": 164}]}}, "schema": []}
{"input": "O. novo-ulmi RNA-7, previously believed to be a satellite-like RNA, is shown to be a defective RNA, derived from OnuMV4-Ld RNA by multiple internal deletions.", "output": {"entities": {"gene": [{"text": "O. novo-ulmi RNA-7", "start": 0, "end": 18}, {"text": "OnuMV4-Ld RNA", "start": 113, "end": 126}]}}, "schema": []}
{"input": "The paramyxovirus fusion (F) protein mediates membrane fusion.", "output": {"entities": {"gene": [{"text": "paramyxovirus fusion (F) protein", "start": 4, "end": 36}]}}, "schema": []}
{"input": "In the present study, we show that SRm160/300 is required for a purine-rich ESE to promote the splicing of a pre-mRNA derived from the Drosophila doublesex gene.", "output": {"entities": {"gene": [{"text": "SRm160/300", "start": 35, "end": 45}, {"text": "ESE", "start": 76, "end": 79}, {"text": "Drosophila doublesex gene", "start": 135, "end": 160}]}}, "schema": []}
{"input": "The coefficient of determination, r2, of the other scores ranged from 0. 56 to 0. 61.", "output": {"entities": {}}, "schema": []}
{"input": "While determination of the protein content of the formulae gave no valid information, RAST/EAST inhibition was highest for cow' s milk, followed by the partially hydrolysed whey formula, partially hydrolysed whey/casein formula, soy/pork collagen formula, and the amino acid formula.", "output": {"entities": {"gene": [{"text": "casein", "start": 213, "end": 219}, {"text": "soy/pork collagen", "start": 229, "end": 246}]}}, "schema": []}
{"input": "In light of the importance of GnRHR, the molecular mechanisms underlying the transcriptional regulation of the human GnRHR (hGnRHR) gene become a key issue in understanding human reproduction.", "output": {"entities": {"gene": [{"text": "GnRHR", "start": 30, "end": 35}, {"text": "human GnRHR", "start": 111, "end": 122}, {"text": "hGnRHR", "start": 124, "end": 130}]}}, "schema": []}
{"input": "Competitive mobility shift assays using either alphaT3-1 nuclear extract or recombinant SF-1 protein clearly indicated that SF-1 is able to interact specifically with this GSE element positioned at-134.", "output": {"entities": {"gene": [{"text": "recombinant SF-1 protein", "start": 76, "end": 100}, {"text": "SF-1", "start": 124, "end": 128}, {"text": "GSE element", "start": 172, "end": 183}]}}, "schema": []}
{"input": "Grade 3 mucositis was reported in 1 patient.", "output": {"entities": {}}, "schema": []}
{"input": "In a heterologous transcriptional system in which the upstream regions of oIFNtau were inserted in front of simian virus 40 (SV40) promoter, the regions between bases-654 and-555 were determined as being the enhancer region required for oIFNtau-SV40-CAT transactivation.", "output": {"entities": {"gene": [{"text": "oIFNtau", "start": 74, "end": 81}, {"text": "simian virus 40 (SV40) promoter", "start": 108, "end": 139}, {"text": "oIFNtau", "start": 237, "end": 244}, {"text": "CAT", "start": 250, "end": 253}]}}, "schema": []}
{"input": "In co-transfection studies, the expression of c-Jun plus c-Fos enhanced the transactivation of oIFNtau-CAT but the expression of GATA-1, GATA-2 or GATA-3 did not.", "output": {"entities": {"gene": [{"text": "c-Jun", "start": 46, "end": 51}, {"text": "c-Fos", "start": 57, "end": 62}, {"text": "oIFNtau", "start": 95, "end": 102}, {"text": "CAT", "start": 103, "end": 106}, {"text": "GATA-1", "start": 129, "end": 135}, {"text": "GATA-2", "start": 137, "end": 143}, {"text": "GATA-3", "start": 147, "end": 153}]}}, "schema": []}
{"input": "The relatively mild defects observed in Rpd3 mutants suggest that the recently identified Groucho and dCtBP corepressor proteins do not function solely through the recruitment of histone deacetylases.", "output": {"entities": {"gene": [{"text": "Rpd3 mutants", "start": 40, "end": 52}, {"text": "Groucho", "start": 90, "end": 97}, {"text": "dCtBP corepressor proteins", "start": 102, "end": 128}, {"text": "histone deacetylases", "start": 179, "end": 199}]}}, "schema": []}
{"input": "Both carbachol (100 microM) and EGF (10 nM) induced Ras activation.", "output": {"entities": {"gene": [{"text": "EGF", "start": 32, "end": 35}, {"text": "Ras", "start": 52, "end": 55}]}}, "schema": []}
{"input": "Dominant negative Sos did not affect carbachol stimulation of HA-ERK2 but inhibited the stimulatory effect of EGF by 60%.", "output": {"entities": {"gene": [{"text": "Sos", "start": 18, "end": 21}, {"text": "HA", "start": 62, "end": 64}, {"text": "ERK2", "start": 65, "end": 69}, {"text": "EGF", "start": 110, "end": 113}]}}, "schema": []}
{"input": "Hrs has a FYVE double zinc finger domain, which specifically binds phosphatidylinositol (3)-phosphate and is conserved in several proteins involved in vesicular traffic.", "output": {"entities": {"gene": [{"text": "Hrs", "start": 0, "end": 3}]}}, "schema": []}
{"input": "Three subgenomes also comprised 15 to 75 nucleotides derived from the 5' part of the NS2 gene.", "output": {"entities": {"gene": [{"text": "NS2 gene", "start": 85, "end": 93}]}}, "schema": []}
{"input": "The hybrid viruses were found to accumulate to high levels in infected plants, to form stable virions, and to be mechanically transmissible.", "output": {"entities": {}}, "schema": []}
{"input": "Nevertheless cryopreservation of spermatozoa in a medium containing neither SP nor biological substances could offer an acceptable cryoprotection of spermatozoa to be used in assisted fertilization procedures, especially for intracytoplasmic sperm injection.", "output": {"entities": {}}, "schema": []}
{"input": "EMSA with crude nuclear extracts demonstrated that stimulation with CD40L results in the induction of NF-kappaB complexes that bind to each of the three NF-kappaB sites and are composed mainly of p50 and RelB, but also include c-Rel and p65.", "output": {"entities": {"gene": [{"text": "CD40L", "start": 68, "end": 73}, {"text": "NF-kappaB complexes", "start": 102, "end": 121}, {"text": "NF-kappaB sites", "start": 153, "end": 168}, {"text": "p50", "start": 196, "end": 199}, {"text": "RelB", "start": 204, "end": 208}, {"text": "c-Rel", "start": 227, "end": 232}, {"text": "p65", "start": 237, "end": 240}]}}, "schema": []}
{"input": "The major transcription factors controlling arginine metabolism in Escherichia coli and Bacillus subtilis, ArgR and AhrC, respectively, are homologous multimeric proteins that form l-arginine-dependent DNA-binding complexes capable of repressing transcription of the biosynthetic genes (both), activating transcription of catabolic genes (AhrC only) or facilitating plasmid dimer resolution (both).", "output": {"entities": {"gene": [{"text": "ArgR", "start": 107, "end": 111}, {"text": "AhrC", "start": 116, "end": 120}, {"text": "AhrC", "start": 339, "end": 343}]}}, "schema": []}
{"input": "The studied protein fragments consist of residues Arg183-His267 of the human ER and residues Lys438-Gln520 of the rat GR.", "output": {"entities": {"gene": [{"text": "human ER", "start": 71, "end": 79}, {"text": "GR", "start": 118, "end": 120}]}}, "schema": []}
{"input": "CONCLUSIONS: Turbutest is a valuable tool in asthmatic patients' training, allowing identification and improvement of an inadequate inhalation technique with Turbuhaler.", "output": {"entities": {}}, "schema": []}
{"input": "The potency of the effect of Nim (0. 5 mg. kg-1 i. p.) was similar to that of NBP (10 mg. kg-1 i. p.).", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSION: NBP pre-treatment or post-treatment markedly enhanced the rCBF to striatum in RMCAO rats.", "output": {"entities": {}}, "schema": []}
{"input": "The aim of this study was to investigate the spontaneous reports of suspected adverse drug reactions, observed in elderly patients (over 65 years of age) in Sicily (Italy) during the period from 1 January 1995 to 31 December 1997.", "output": {"entities": {}}, "schema": []}
{"input": "The high density lipoprotein (HDL) receptor mediates the uptake of cholesterol and cholesteryl esters, substrates for steroidogenesis, from an HDL particle in the adrenal gland and gonads.", "output": {"entities": {"gene": [{"text": "high density lipoprotein (HDL) receptor", "start": 4, "end": 43}, {"text": "HDL", "start": 143, "end": 146}]}}, "schema": []}
{"input": "Ozagrel, ifenprodil, cinnarizine and dilazep were more effective than pentoxifylline in increasing rCBF at the HPC.", "output": {"entities": {}}, "schema": []}
{"input": "Using sequence information from human BMAL1 (hBMAL1) cDNAs previously reported by our laboratory, we have isolated and characterized cDNAs encoding three splice variants of the mouse BMAL1 (mBMAL1) gene.", "output": {"entities": {"gene": [{"text": "human BMAL1", "start": 32, "end": 43}, {"text": "hBMAL1", "start": 45, "end": 51}, {"text": "mouse BMAL1", "start": 177, "end": 188}, {"text": "mBMAL1", "start": 190, "end": 196}]}}, "schema": []}
{"input": "Comparison with the bHLH/PAS family genes revealed that the intron/exon splice pattern of mBMAL1 most closely matches that of the mAhr, which suggests that BMAL1 and Ahr belong to the same subclass and may be derived from a common primordial gene.", "output": {"entities": {"gene": [{"text": "bHLH", "start": 20, "end": 24}, {"text": "PAS", "start": 25, "end": 28}, {"text": "mBMAL1", "start": 90, "end": 96}, {"text": "mAhr", "start": 130, "end": 134}, {"text": "BMAL1", "start": 156, "end": 161}, {"text": "Ahr", "start": 166, "end": 169}]}}, "schema": []}
{"input": "We were able to detect significant differences in functional residual capacity adjusted for weight or height, and compliance of the respiratory system adjusted for weight or lung volume in the ILD infants compared to the healthy controls or infants who had PPHN, indicating that these PFTs were sensitive enough to determine abnormal lung function in this age group.", "output": {"entities": {}}, "schema": []}
{"input": "Classical ligand-activated nuclear receptors (e. g. thyroid hormone receptor, retinoic acid receptor), orphan nuclear receptors (e. g.", "output": {"entities": {"gene": [{"text": "thyroid hormone receptor", "start": 52, "end": 76}, {"text": "retinoic acid receptor", "start": 78, "end": 100}, {"text": "orphan nuclear receptors", "start": 103, "end": 127}]}}, "schema": []}
{"input": "We have shown previously that in contrast to other extracellular matrix molecules pepsin-solubilized collagen VI (CVI) can stimulate DNA synthesis of various mesenchymal cell types, apparently independent of integrin-mediated signal transduction.", "output": {"entities": {"gene": [{"text": "pepsin", "start": 82, "end": 88}, {"text": "collagen VI", "start": 101, "end": 112}, {"text": "CVI", "start": 114, "end": 117}, {"text": "integrin", "start": 208, "end": 216}]}}, "schema": []}
{"input": "The enzyme displays optimal activity at about 0. 5 mM pantoate (k (cat) 0. 63 s (-1)) and at pH 7. 8.", "output": {"entities": {}}, "schema": []}
{"input": "Taken together, these results demonstrate that the RP, like the 20S proteasome, is functionally and structurally conserved among eukaryotes and indicate that the plant RPT subunits, like their yeast counterparts, have non-redundant functions.", "output": {"entities": {"gene": [{"text": "RP", "start": 51, "end": 53}, {"text": "20S proteasome", "start": 64, "end": 78}, {"text": "plant RPT subunits", "start": 162, "end": 180}]}}, "schema": []}
{"input": "Structure and expression of the mouse growth hormone receptor/growth hormone binding protein gene.", "output": {"entities": {"gene": [{"text": "mouse growth hormone receptor", "start": 32, "end": 61}, {"text": "growth hormone binding protein gene", "start": 62, "end": 97}]}}, "schema": []}
{"input": "Repair of double-strand breaks (DSBs) in chromosomal DNA by nonhomologous end-joining (NHEJ) is not well characterized in the yeast Saccharomyces cerevisiae.", "output": {"entities": {}}, "schema": []}
{"input": "Thus, elongin C is found to oligomerize in solution and to undergo significant structural rearrangements upon binding of two different partner proteins.", "output": {"entities": {"gene": [{"text": "elongin C", "start": 6, "end": 15}]}}, "schema": []}
{"input": "Gel filtration and co-immunoprecipitation analyses reveal that Mad2p tightly associates with another spindle checkpoint component, Mad1p.", "output": {"entities": {"gene": [{"text": "Mad2p", "start": 63, "end": 68}, {"text": "Mad1p", "start": 131, "end": 136}]}}, "schema": []}
{"input": "John leonard dawson", "output": {"entities": {}}, "schema": []}
{"input": "Microcirculatory oxygenation and shunting in sepsis and shock.", "output": {"entities": {}}, "schema": []}
{"input": "The present investigation conducted in a population of 258 dentally aware individuals in the age range 20-69 years, was initiated to elucidate the relationship between tobacco smoking and supragingival calculus, taking into account possible confounding factors such as age, gender, oral hygiene and gingival inflammation.", "output": {"entities": {}}, "schema": []}
{"input": "Interaction of HRI with Hsc70 was required for the transformation of HRI, as the Hsc70 antagonist clofibric acid inhibited the folding of HRI into a mature-competent conformation.", "output": {"entities": {"gene": [{"text": "HRI", "start": 15, "end": 18}, {"text": "Hsc70", "start": 24, "end": 29}, {"text": "HRI", "start": 69, "end": 72}, {"text": "Hsc70", "start": 81, "end": 86}, {"text": "HRI", "start": 138, "end": 141}]}}, "schema": []}
{"input": "In the budding yeast, Saccharomyces cerevisiae, replicators can function outside the chromosome as autonomously replicating sequence (ARS) elements; however, within chromosome III, certain ARSs near the transcriptionally silent HML locus show no replication origin activity.", "output": {"entities": {"gene": [{"text": "HML locus", "start": 228, "end": 237}]}}, "schema": []}
{"input": "These results suggest that, for the HML ARS cluster (ARS303, ARS320, and ARS302), inactivity of origins is independent of local transcriptional silencing, even though origins and silencers share key cis-and trans-acting components.", "output": {"entities": {"gene": [{"text": "HML", "start": 36, "end": 39}, {"text": "ARS303", "start": 53, "end": 59}, {"text": "ARS320", "start": 61, "end": 67}, {"text": "ARS302", "start": 73, "end": 79}]}}, "schema": []}
{"input": "We report the construction of an approximately 1. 7-Mb sequence-ready YAC/BAC clone contig of 8p22-p23.", "output": {"entities": {}}, "schema": []}
{"input": "The recruitment of constitutively phosphorylated p185 (neu) and the activated mitogenic pathway proteins to this membrane-microfilament interaction site provides a physical model for integrating the assembly of the mitogenic pathway with the transmission of growth factor signal to the cytoskeleton.", "output": {"entities": {"gene": [{"text": "p185", "start": 49, "end": 53}, {"text": "neu", "start": 55, "end": 58}]}}, "schema": []}
{"input": "ECG-gated myocardial Technetium-99m sestamibi SPECT is a useful technique to measure myocardial perfusion and function simultaneously.", "output": {"entities": {}}, "schema": []}
{"input": "The controversy of significance testing: misconceptions and alternatives.", "output": {"entities": {}}, "schema": []}
{"input": "The arrangement of these cutoff-levels leads to a sensitivity of 85% at a specificity of 55% for Protein S100 when measured by RIA, and to a sensitivity of 77% at a specificity of 61% when measured by LIA.", "output": {"entities": {"gene": [{"text": "Protein S100", "start": 97, "end": 109}]}}, "schema": []}
{"input": "Null alleles of SAS4 and SAS5 bypassed the role of the Abf1p binding site of the HMR-E silencer but not the role of the ACS or Rap1p binding site.", "output": {"entities": {"gene": [{"text": "SAS4", "start": 16, "end": 20}, {"text": "SAS5", "start": 25, "end": 29}, {"text": "Abf1p binding site", "start": 55, "end": 73}, {"text": "HMR-E silencer", "start": 81, "end": 95}, {"text": "ACS", "start": 120, "end": 123}, {"text": "Rap1p binding site", "start": 127, "end": 145}]}}, "schema": []}
{"input": "RESULTS: 256 Periods of TTP or PUNP were reported by men and 174 by women.", "output": {"entities": {}}, "schema": []}
{"input": "Cytokine-induced NF-kappa B DNA binding activity, RelA nuclear translocation, I kappa B alpha degradation, I kappa B serine 32 phosphorylation, and I kappa B kinase (IKK) activity were blocked by curcumin treatment.", "output": {"entities": {"gene": [{"text": "NF-kappa B", "start": 17, "end": 27}, {"text": "RelA", "start": 50, "end": 54}, {"text": "I kappa B alpha", "start": 78, "end": 93}, {"text": "I kappa B", "start": 107, "end": 116}, {"text": "I kappa B kinase", "start": 148, "end": 164}, {"text": "IKK", "start": 166, "end": 169}]}}, "schema": []}
{"input": "To estimate the locations of sources with the TF-MUSIC algorithm, we first set the target region on the spectrogram of the somatosensory responses.", "output": {"entities": {}}, "schema": []}
{"input": "Immunohistochemical staining with MIB-1 and p53 antibodies showed low (< 1%) and negative reaction.", "output": {"entities": {"gene": [{"text": "MIB-1", "start": 34, "end": 39}, {"text": "p53 antibodies", "start": 44, "end": 58}]}}, "schema": []}
{"input": "Two patients with recurrent tumors had high S-phase fractions both on the first resected specimens and at the time of the second operation.", "output": {"entities": {}}, "schema": []}
{"input": "Treatment of unstable angina: role of antithrombotic therapy.", "output": {"entities": {}}, "schema": []}
{"input": "Mutations of the RET gene, encoding a receptor tyrosine kinase, have been associated with the inherited cancer syndromes MEN 2A and MEN 2B.", "output": {"entities": {"gene": [{"text": "RET gene", "start": 17, "end": 25}, {"text": "receptor tyrosine kinase", "start": 38, "end": 62}]}}, "schema": []}
{"input": "Protein kinase A-Ialpha subunit-directed antisense inhibition of ovarian cancer cell growth: crosstalk with tyrosine kinase signaling pathway.", "output": {"entities": {"gene": [{"text": "Protein kinase A-Ialpha", "start": 0, "end": 23}, {"text": "tyrosine kinase", "start": 108, "end": 123}]}}, "schema": []}
{"input": "During both encephalopathy episodes, CSF protein and immunoglobulin G (IgG) levels were elevated without an increased IgG index or IgG synthesis rate.", "output": {"entities": {"gene": [{"text": "immunoglobulin G", "start": 53, "end": 69}, {"text": "IgG", "start": 71, "end": 74}, {"text": "IgG", "start": 118, "end": 121}, {"text": "IgG", "start": 131, "end": 134}]}}, "schema": []}
{"input": "SCOB testing of food-restricted animals, using a multiple fixed ratio (FR)/fixed interval (FI) schedule (FR20: FI120), was conducted prior to each exposure to maintain the operant behavior; the data from Weeks-1, 4, 8, and 13 were evaluated for evidence of neurotoxicity.", "output": {"entities": {}}, "schema": []}
{"input": "Differential expression was confirmed by Northern blot analysis employing multiple normal and tumor cell lines.", "output": {"entities": {}}, "schema": []}
{"input": "Several genes or transcriptional units were identified, including the 3' end of ribosomal s6 kinase (Rsk3); two apparently intronless and ORF-less genes; and Gpr31, an intronless, putative G-protein coupled receptor.", "output": {"entities": {"gene": [{"text": "ribosomal s6 kinase", "start": 80, "end": 99}, {"text": "Rsk3", "start": 101, "end": 105}, {"text": "Gpr31", "start": 158, "end": 163}, {"text": "G-protein coupled receptor", "start": 189, "end": 215}]}}, "schema": []}
{"input": "The results suggest that GATA-5 may have specific downstream targets and that GATA-4,-5, and-6 can only partially substitute for each other in cardiogenesis.", "output": {"entities": {"gene": [{"text": "GATA-5", "start": 25, "end": 31}, {"text": "GATA-4,-5, and-6", "start": 78, "end": 94}]}}, "schema": []}
{"input": "This study was designed to compare the efficacy of efegatran plus streptokinase versus heparin plus accelerated tissue plasminogen activator (TPA) in coronary reperfusion in acute MI.", "output": {"entities": {"gene": [{"text": "streptokinase", "start": 66, "end": 79}, {"text": "tissue plasminogen activator", "start": 112, "end": 140}, {"text": "TPA", "start": 142, "end": 145}]}}, "schema": []}
{"input": "From February 1991 to August 1997, 124 patients with endometrial carcinoma were treated postoperatively with high-dose-rate vaginal vault brachytherapy as the only adjuvant treatment.", "output": {"entities": {}}, "schema": []}
{"input": "Twelve patients had stage IBG3, 14 had ICG1, 9 had ICG2, and 3 had ICG3 disease.", "output": {"entities": {}}, "schema": []}
{"input": "For EPV 3, 10, or 40, the bias exceeded 25% for 7, 3, and 1 in the 8-predictor model respectively, when a conventional selection criterion was used (alpha = 0. 05).", "output": {"entities": {}}, "schema": []}
{"input": "Me (2) SO-induced neuronal differentiation of N1E-115 neuroblastoma cells increased both the expression of the endogenous Ntr-1 gene and reporter genes driven by NTR-1 promoter sequences by 3-4-fold.", "output": {"entities": {"gene": [{"text": "endogenous Ntr-1 gene", "start": 111, "end": 132}, {"text": "NTR-1 promoter sequences", "start": 162, "end": 186}]}}, "schema": []}
{"input": "Although the Src tyrosine kinase induces constitutive Stat3 phosphorylation on tyrosine, activation of Stat3-mediated gene regulation requires both tyrosine and serine phosphorylation of Stat3.", "output": {"entities": {"gene": [{"text": "Src tyrosine kinase", "start": 13, "end": 32}, {"text": "Stat3", "start": 54, "end": 59}, {"text": "Stat3", "start": 103, "end": 108}, {"text": "Stat3", "start": 187, "end": 192}]}}, "schema": []}
{"input": "RESULTS: Factors associated with significantly (P <. 05) increased risk of treatment failure in a Cox multivariate analysis included age older than 45 years (relative hazard, 1. 17; 95% confidence interval [CI], 1. 02-1. 33), Karnofsky performance score less than 90% (1. 27; 95% CI, 1. 07-1. 51), absence of hormone receptors (1. 31; 95% CI, 1. 15-1. 51), prior use of adjuvant chemotherapy (1. 31; 95% CI, 1. 10-1. 56), initial disease-free survival interval after adjuvant treatment of no more than 18 months (1. 99; 95% CI, 1. 62-2. 43), metastases in the liver (1. 47; 95% CI, 1. 20-1. 80) or central nervous system (1. 56; 95% CI, 0. 99-2. 46 [approaches significance]) vs soft tissue, bone, or lung, 3 or more sites of metastatic disease (1. 32; 95% CI, 1. 13-1. 54), and incomplete response vs complete response to standard-dose chemotherapy (1. 65; 95% CI, 1. 36-1. 99).", "output": {"entities": {}}, "schema": []}
{"input": "The proteasome is a large complex consisting of two multisubunit structures, the 20S and 19S (PA700) or P28 complexes, that combine to form the 26S particles.", "output": {"entities": {"gene": [{"text": "20S", "start": 81, "end": 84}, {"text": "19S", "start": 89, "end": 92}, {"text": "PA700", "start": 94, "end": 99}, {"text": "P28 complexes", "start": 104, "end": 117}, {"text": "26S particles", "start": 144, "end": 157}]}}, "schema": []}
{"input": "We have cloned cDNA and genomic DNA for a mouse gene encoding a protein with significant sequence similarity to conserved domains found in proteins of the Spo11p family.", "output": {"entities": {"gene": [{"text": "Spo11p family", "start": 155, "end": 168}]}}, "schema": []}
{"input": "RT-PCR and in situ hybridization analyses of a time course of juvenile testis development indicate that Spo11 expression begins in early meiotic Prophase I, prior to the pachytene stage, with increasing accumulation of mRNA through the pachytene stage.", "output": {"entities": {"gene": [{"text": "Spo11", "start": 104, "end": 109}]}}, "schema": []}
{"input": "Animals were put to death 8 weeks later and the grafts were sterilely explanted and analyzed via microbiologic culture and standard histologic procedures for evidence of infection.", "output": {"entities": {}}, "schema": []}
{"input": "Oseltamivir (GS4104), which can be administered orally, is the prodrug of GS4071, a potent and selective inhibitor of influenzavirus neuraminidases.", "output": {"entities": {"gene": [{"text": "influenzavirus neuraminidases", "start": 118, "end": 147}]}}, "schema": []}
{"input": "We also show that activation of protein kinase A (PKA) signaling is sufficient to down-regulate caveolin-1 protein expression and promoter activity.", "output": {"entities": {"gene": [{"text": "protein kinase A", "start": 32, "end": 48}, {"text": "PKA", "start": 50, "end": 53}, {"text": "caveolin-1 protein", "start": 96, "end": 114}]}}, "schema": []}
{"input": "Phosphatidylinositol 3-kinase requirement in activation of the ras/C-raf-1/MEK/ERK and p70 (s6k) signaling cascade by the insulinomimetic agent vanadyl sulfate.", "output": {"entities": {"gene": [{"text": "Phosphatidylinositol 3-kinase", "start": 0, "end": 29}, {"text": "ras", "start": 63, "end": 66}, {"text": "C-raf-1", "start": 67, "end": 74}, {"text": "MEK", "start": 75, "end": 78}, {"text": "ERK", "start": 79, "end": 82}, {"text": "p70", "start": 87, "end": 90}, {"text": "s6k", "start": 92, "end": 95}]}}, "schema": []}
{"input": "For example, introduction of immunogenic and purification tag sequences into the C-terminal coding region significantly decreased bop gene mRNA and protein accumulation.", "output": {"entities": {"gene": [{"text": "bop gene mRNA", "start": 130, "end": 143}]}}, "schema": []}
{"input": "We recommend that paracervical block with lignocaine should be used in conjunction with i. v. sedation/analgesia during egg collection performed through the transvaginal route under ultrasound guidance (TUGOR) to reduce the pain of the procedure.", "output": {"entities": {}}, "schema": []}
{"input": "This report describes a patient with a previous inferior acute myocardial infarction who developed right ventricular infarction with significant anterior lead ST segment elevation (V1-V4) caused by the loss of two large right ventricular branches during a coronary angioplasty of the right coronary artery.", "output": {"entities": {}}, "schema": []}
{"input": "PURPOSE: Previous WR-2721 human pharmacokinetic studies were limited to plasma levels in patients receiving platinum-based compounds, and none includes the effects of WR-2721 on endogenous thiols.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSIONS: In addition to the superiority of octafluoropropane-filled microspheres to air-filled microspheres for LV opacification, the efficacy of OCTA is relatively unaffected by impaired LV function and is less susceptible to the effects of poor echogenicity than AIR.", "output": {"entities": {}}, "schema": []}
{"input": "These kinases belong to a new subfamily related to the Trk subfamily.", "output": {"entities": {"gene": [{"text": "Trk subfamily", "start": 55, "end": 68}]}}, "schema": []}
{"input": "The data indicate that etr-1 is essential for muscle development in C. elegans, perhaps by playing a role in post-transcriptional processing of some muscle component, and thus suggesting a possible conservation of gene function with human CUG-bp.", "output": {"entities": {"gene": [{"text": "etr-1", "start": 23, "end": 28}, {"text": "human CUG-bp", "start": 233, "end": 245}]}}, "schema": []}
{"input": "Detection of poisoning by Impila (Callilepis laureola) in a mother and child.", "output": {"entities": {}}, "schema": []}
{"input": "In HCMV (Towne)-infected HF cells at 24 to 48 h, IE2 also accumulated in newly formed viral DNA replication compartments containing the polymerase processivity factor (UL44), the single-stranded DNA binding protein (SSB; UL57), the UL112-113 accessory protein, and newly incorporated bromodeoxyuridine (BrdU).", "output": {"entities": {"gene": [{"text": "IE2", "start": 49, "end": 52}, {"text": "polymerase processivity factor", "start": 136, "end": 166}, {"text": "UL44", "start": 168, "end": 172}, {"text": "single-stranded DNA binding protein", "start": 179, "end": 214}, {"text": "SSB", "start": 216, "end": 219}, {"text": "UL57", "start": 221, "end": 225}, {"text": "UL112-113 accessory protein", "start": 232, "end": 259}]}}, "schema": []}
{"input": "Macroscopic researches on heart vascularization have indicated that the angioarchitecture of the conducting system differs from that of the normal myocardium.", "output": {"entities": {}}, "schema": []}
{"input": "However, reoperation for bulky cervical disease (group 3) rarely results in normal calcitonin levels and is associated with a high incidence of permanent hypoparathyroidism.", "output": {"entities": {"gene": [{"text": "calcitonin", "start": 83, "end": 93}]}}, "schema": []}
{"input": "We present a case of carcinoma of the breast presenting concurrently with SSc that subsequently progressed to dialysis-dependent renal failure in just 1 month.", "output": {"entities": {}}, "schema": []}
{"input": "The GPI anchor moiety is either absent or present at a very low level in the polypeptide expressed from the cDNA that contained both the signal peptide and GPI signal sequences.", "output": {"entities": {}}, "schema": []}
{"input": "They self-completed the SF-36 questionnaire and their QoL was described and retrospectively compared to that of historical controls.", "output": {"entities": {}}, "schema": []}
{"input": "There was a trend toward an association between IENF and sural nerve unmyelinated fiber densities (r = 0. 32, p = 0. 054).", "output": {"entities": {}}, "schema": []}
{"input": "FISH using a whole chromosome 4 paint demonstrated multiple rearrangements involving chromosome 4 in MCF-7 AdVp3000 and MCF-7 MX, while S1-M1-80 contained only a simple reciprocal translocation.", "output": {"entities": {}}, "schema": []}
{"input": "The MXR gene encodes a half-transporter and the absence of cytogenetic evidence of coamplification of other regions suggests that a partner may not be overexpressed, and instead the MXR half-transporter homodimerizes to mediate drug transport.", "output": {"entities": {"gene": [{"text": "MXR gene", "start": 4, "end": 12}, {"text": "MXR half-transporter", "start": 182, "end": 202}]}}, "schema": []}
{"input": "Serum insulin-like growth factor I (IGF-I) SD score increased from-2. 2 and-4. 2 in men and women, respectively, to 1. 8 and-0. 9 at 6 months and 0. 8 and-0. 7 at 12 months.", "output": {"entities": {"gene": [{"text": "Serum insulin-like growth factor I", "start": 0, "end": 34}, {"text": "IGF-I", "start": 36, "end": 41}]}}, "schema": []}
{"input": "The level of serum creatine kinase was significantly high 2 days after ESWIB, but it recovered in a week.", "output": {"entities": {"gene": [{"text": "serum creatine kinase", "start": 13, "end": 34}]}}, "schema": []}
{"input": "Several 7SL RNA-encoding sequences and various intergenic spacers were amplified from the individual HindIII fragments of about 1. 3 and 2. 8 kb.", "output": {"entities": {"gene": [{"text": "7SL RNA-encoding sequences", "start": 8, "end": 34}, {"text": "HindIII fragments", "start": 101, "end": 118}]}}, "schema": []}
{"input": "Analysis of its genomic region revealed that the 13-kb Cdc6 gene is divided into 12 exons by 11 introns.", "output": {"entities": {"gene": [{"text": "Cdc6 gene", "start": 55, "end": 64}]}}, "schema": []}
{"input": "Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo.", "output": {"entities": {"gene": [{"text": "myosin-binding subunit", "start": 19, "end": 41}, {"text": "MBS", "start": 43, "end": 46}, {"text": "myosin phosphatase", "start": 51, "end": 69}, {"text": "Rho-kinase", "start": 73, "end": 83}]}}, "schema": []}
{"input": "Because the Pit-1 sites in the hGH-N gene promoter are insufficient for such gene activation in vivo, these data suggested a unique chromatin-mediated developmental role for Pit-1 in the hGH LCR.", "output": {"entities": {"gene": [{"text": "Pit-1 sites", "start": 12, "end": 23}, {"text": "hGH-N gene promoter", "start": 31, "end": 50}, {"text": "Pit-1", "start": 174, "end": 179}, {"text": "hGH LCR", "start": 187, "end": 194}]}}, "schema": []}
{"input": "Recombinant prenylcysteine lyase was produced in a baculovirus-Sf9 expression system.", "output": {"entities": {"gene": [{"text": "Recombinant prenylcysteine lyase", "start": 0, "end": 32}]}}, "schema": []}
{"input": "Mycoplasma hominis infections are easily missed because conventional methods for bacterial detection may fail.", "output": {"entities": {}}, "schema": []}
{"input": "For this purpose, we used a series of plasmid constructs encoding different forms of the envelope glycoprotein E of the flavivirus tick-borne encephalitis virus.", "output": {"entities": {"gene": [{"text": "envelope glycoprotein E of the flavivirus tick-borne encephalitis virus", "start": 89, "end": 160}]}}, "schema": []}
{"input": "By an induced-fit mechanism, contacts with the anticodon can activate formation of a robust transition state at a site over 70 A away.", "output": {"entities": {}}, "schema": []}
{"input": "This revealed a minimum of six novel OSBP-related proteins, designated ORP-1 to ORP-6.", "output": {"entities": {"gene": [{"text": "OSBP-related proteins", "start": 37, "end": 58}, {"text": "ORP-1", "start": 71, "end": 76}, {"text": "ORP-6", "start": 80, "end": 85}]}}, "schema": []}
{"input": "In conclusion: (i) TECRA kit is suggested to be used for screening SE producing strains; (ii) SET-RPLA and RIDASCREEN kits are suitable for epidemiological investigation of SE types, but the lack of ability for detecting SEE, long time required for testing with SET-RPLA kit and high background when using RIDASCREEN kit must be overcome; and (iii) because of the complicated test procedures and the lack of ability for detecting SEE, the practicality of SET-EIA kit in screening and epidemiological research purposes is low.", "output": {"entities": {}}, "schema": []}
{"input": "Comparison of immunoassay kits for detection of staphylococcal enterotoxins produced by Staphylococcus aureus", "output": {"entities": {"gene": [{"text": "staphylococcal enterotoxins", "start": 48, "end": 75}]}}, "schema": []}
{"input": "Sequence analysis of the promoter region showed no TATA box but identified consensus binding motifs for Sp1, CREB, and half sites of the estrogen receptor binding site.", "output": {"entities": {"gene": [{"text": "Sp1", "start": 104, "end": 107}, {"text": "CREB", "start": 109, "end": 113}, {"text": "estrogen receptor binding site", "start": 137, "end": 167}]}}, "schema": []}
{"input": "Sak kinase gene structure and transcriptional regulation.", "output": {"entities": {"gene": [{"text": "Sak kinase", "start": 0, "end": 10}]}}, "schema": []}
{"input": "Based on a type I error of 0. 05, our study had a power greater than or equal to 75% to detect group differences in treatment effect of greater than or equal to 15% to 20%.", "output": {"entities": {}}, "schema": []}
{"input": "However, no genetic alteration was detected in any of the cancers examined.", "output": {"entities": {}}, "schema": []}
{"input": "Statins: lower lipids and better bones? Although statins are widely used as cholesterol-lowering drugs, a recent study suggests that these compounds have anabolic effects on bone and could be developed into new treatments for common metabolic bone diseases such as osteoporosis", "output": {"entities": {"gene": [{"text": "Statins", "start": 0, "end": 7}]}}, "schema": []}
{"input": "Leukocyte cultures, prepared from blood drawn from these 18 children at 6 months of age, produced lower yields of IFN than those of the remaining 53 children, when stimulated with adenovirus (P < 0. 001), coronavirus (P < 0. 001) or rhinovirus (P = 0. 002).", "output": {"entities": {"gene": [{"text": "IFN", "start": 114, "end": 117}]}}, "schema": []}
{"input": "In the BF ECT group the-age based dose would have been similarly dependent on the initial seizure threshold level.", "output": {"entities": {}}, "schema": []}
{"input": "Haycocknema perplexum n. g., n. sp.", "output": {"entities": {}}, "schema": []}
{"input": "Hypothermia After Cardiac Arrest (HACA) Study Group.", "output": {"entities": {}}, "schema": []}
{"input": "Two US commercial cultivars (Tehama and Vina), three European commercial cultivars (Esterhazy, 139, G120) and five New Zealand selections (Rex, Dublin' s Glory, Meyric, McKinster, Stanley) were evaluated.", "output": {"entities": {}}, "schema": []}
{"input": "Previously, we showed that the APRE is a cytokine [tumor necrosis factor-alpha (TNFalpha)]-inducible enhancer by binding the heterodimeric nuclear factor-kappaB (NF-kappaB) complex Rel A x NF-kappaB1.", "output": {"entities": {"gene": [{"text": "tumor necrosis factor-alpha", "start": 51, "end": 78}, {"text": "TNFalpha", "start": 80, "end": 88}, {"text": "heterodimeric nuclear factor-kappaB", "start": 125, "end": 160}, {"text": "NF-kappaB", "start": 162, "end": 171}, {"text": "Rel A", "start": 181, "end": 186}, {"text": "NF-kappaB1", "start": 189, "end": 199}]}}, "schema": []}
{"input": "Angiotensin II induces nuclear factor (NF)-kappaB1 isoforms to bind the angiotensinogen gene acute-phase response element: a stimulus-specific pathway for NF-kappaB activation.", "output": {"entities": {"gene": [{"text": "Angiotensin II", "start": 0, "end": 14}, {"text": "nuclear factor (NF)-kappaB1 isoforms", "start": 23, "end": 59}, {"text": "angiotensinogen gene", "start": 72, "end": 92}, {"text": "NF-kappaB", "start": 155, "end": 164}]}}, "schema": []}
{"input": "Arhythmacanthus Yamaguti, 1935 is maintained as a synonym of Heterosentis because the distinction between two and three hook types is made equivocal when the transition between the apical and subapical hooks is gradual.", "output": {"entities": {}}, "schema": []}
{"input": "We describe a case of acetaminophen overdose that was treated with both hemodialysis (HD) and NAC due to severe intoxication and slow drug clearance.", "output": {"entities": {}}, "schema": []}
{"input": "Following conditioning, a single coat of adhesive was applied and light-cured.", "output": {"entities": {}}, "schema": []}
{"input": "Upon tyrosine phosphorylation at the ITIMs, these molecules recruit SH2 domain-containing phosphatases such as SH2-containing tyrosine phosphatase-1 and negatively regulate cell activity.", "output": {"entities": {"gene": [{"text": "SH2", "start": 68, "end": 71}, {"text": "SH2", "start": 111, "end": 114}, {"text": "tyrosine phosphatase-1", "start": 126, "end": 148}]}}, "schema": []}
{"input": "These results suggest that VP1 was efficiently transported to the nucleus and localized in the discrete subnuclear regions, possibly with VP2 and VP3.", "output": {"entities": {"gene": [{"text": "VP1", "start": 27, "end": 30}, {"text": "VP2", "start": 138, "end": 141}, {"text": "VP3", "start": 146, "end": 149}]}}, "schema": []}
{"input": "The case for completing the lymphadenectomy when positive lymph nodes are found during radical hysterectomy for cervical carcinoma.", "output": {"entities": {}}, "schema": []}
{"input": "Isolation of cDNAs encoding gibbon and monkey platelet and T cell activation antigen 1 (PTA1).", "output": {"entities": {"gene": [{"text": "cDNAs encoding gibbon and monkey platelet and T cell activation antigen 1", "start": 13, "end": 86}, {"text": "PTA1", "start": 88, "end": 92}]}}, "schema": []}
{"input": "All clones and strains produced have been deposited in the EUROFAN genetic stock centre (EUROSCARF, Frankfurt).", "output": {"entities": {}}, "schema": []}
{"input": "High resolution computed tomography of the lungs in patients with rheumatoid arthritis.", "output": {"entities": {}}, "schema": []}
{"input": "Actins show two different forms of N-terminal processing dependent on their N-terminal sequence.", "output": {"entities": {"gene": [{"text": "Actins", "start": 0, "end": 6}]}}, "schema": []}
{"input": "All four domains were linked via proline-threonine-rich peptides.", "output": {"entities": {}}, "schema": []}
{"input": "METHODS: The former group included patients who had been treated with at least four PGE1 alpha-ciclodestrina, short-term treatment cycles per year while the latter was a historical reference group managed without prostaglandins.", "output": {"entities": {}}, "schema": []}
{"input": "Zebrafish cyclops (cyc) encodes a Transforming Growth Factor beta (TGFbeta) signaling factor closely related to mouse Nodal.", "output": {"entities": {"gene": [{"text": "cyclops", "start": 10, "end": 17}, {"text": "cyc", "start": 19, "end": 22}, {"text": "Transforming Growth Factor beta", "start": 34, "end": 65}, {"text": "TGFbeta", "start": 67, "end": 74}, {"text": "Nodal", "start": 118, "end": 123}]}}, "schema": []}
{"input": "The genome organization of the mite-transmitted wheat streak mosaic virus (WSMV) appears to parallel that of members of the Potyviridae with monopartite genomes, but there are substantial amino acid dissimilarities with other potyviral polyproteins.", "output": {"entities": {}}, "schema": []}
{"input": "The two-hybrid assay was then performed using full-length genes of CI, HC-Pro, P1, P3, and CP, but no heterologous interactions were detected.", "output": {"entities": {"gene": [{"text": "CI", "start": 67, "end": 69}, {"text": "HC-Pro", "start": 71, "end": 77}, {"text": "P1", "start": 79, "end": 81}, {"text": "P3", "start": 83, "end": 85}, {"text": "CP", "start": 91, "end": 93}]}}, "schema": []}
{"input": "Diverse endogenous light chains contribute to basement membrane reactivity in nonautoimmune mice transgenic for an anti-laminin Ig heavy chain.", "output": {"entities": {"gene": [{"text": "anti-laminin Ig heavy chain", "start": 115, "end": 142}]}}, "schema": []}
{"input": "Mechanisms of tachyphylaxis in regional anesthesia of long duration", "output": {"entities": {}}, "schema": []}
{"input": "Dermatology is no exception.", "output": {"entities": {}}, "schema": []}
{"input": "Molecular cloning of a novel human I-mfa domain-containing protein that differently regulates human T-cell leukemia virus type I and HIV-1 expression.", "output": {"entities": {"gene": [{"text": "human I-mfa domain-containing protein", "start": 29, "end": 66}]}}, "schema": []}
{"input": "The central (R) domain is responsible for receptor-binding activity whereas the N-terminal (T) domain mediates translocation, the process by which the C-terminal cytotoxic domain is transported from the receptor to the site of its cytotoxicity.", "output": {"entities": {}}, "schema": []}
{"input": "We have previously demonstrated that expression of the gene for the reproductive neuropeptide, GnRH, is repressed by the glutamate/NO/cyclic GMP (cGMP) signal transduction pathway through cGMP-dependent protein kinase in the hypothalamic GnRH-secreting neuronal cell line GT1-7.", "output": {"entities": {"gene": [{"text": "GnRH", "start": 95, "end": 99}, {"text": "cGMP-dependent protein kinase", "start": 188, "end": 217}, {"text": "GnRH", "start": 238, "end": 242}]}}, "schema": []}
{"input": "MSSPs are believed to regulate DNA replication, transcription, apopotosis and cell cycle progression by interacting with the C-MYC protein.", "output": {"entities": {"gene": [{"text": "MSSPs", "start": 0, "end": 5}, {"text": "C-MYC protein", "start": 125, "end": 138}]}}, "schema": []}
{"input": "As no complete PPARgamma antagonists have been described hitherto, we have constructed a dominant-negative mutant receptor to inhibit wild-type PPARgamma action.", "output": {"entities": {"gene": [{"text": "PPARgamma", "start": 15, "end": 24}, {"text": "PPARgamma", "start": 144, "end": 153}]}}, "schema": []}
{"input": "Forty 4-month old SD female rats were randomly divided into four groups, namely sham operation, bilateral ovariectomy, ovariectomy plus supplementary ethinyl estradiol (0. 2 microgram/100 g B.", "output": {"entities": {}}, "schema": []}
{"input": "The requirement of 3' complementarity for a ligation reaction is reaffirmed by results from 1 nt insertions on either the 3'-or 5'-side of the nick.", "output": {"entities": {}}, "schema": []}
{"input": "Expression in early postnatal pituitary and in pre-somatotrophic cells suggests that Zn-16 could play a role in pituitary development prior to somatotroph differentiation.", "output": {"entities": {"gene": [{"text": "Zn-16", "start": 85, "end": 90}]}}, "schema": []}
{"input": "Mouse growth hormone transcription factor Zn-16: unique bipartite structure containing tandemly repeated zinc finger domains not reported in rat Zn-15.", "output": {"entities": {"gene": [{"text": "Mouse growth hormone transcription factor Zn-16", "start": 0, "end": 47}, {"text": "rat Zn-15", "start": 141, "end": 150}]}}, "schema": []}
{"input": "The CCAAT core sequence mutants in which both CIII and CI/CII were abolished, also increased the promoter activity.", "output": {"entities": {}}, "schema": []}
{"input": "Finally, the mechanism of ASK1 activation involves, in part, homo-oligomerization.", "output": {"entities": {"gene": [{"text": "ASK1", "start": 26, "end": 30}]}}, "schema": []}
{"input": "Two other patients underwent PRFR.", "output": {"entities": {}}, "schema": []}
{"input": "The variations were caused by opposite shifts in TSH frequency distribution in mothers and neonates.", "output": {"entities": {"gene": [{"text": "TSH", "start": 49, "end": 52}]}}, "schema": []}
{"input": "However, such a mechanism was not detected in preliminary observations on M. synoviae.", "output": {"entities": {}}, "schema": []}
{"input": "The expression of the yam8 (+) cDNA in the mid1 mutant cells partially remediated the mid phenotype and resulted in a slight increase in Ca (2 +) uptake activity.", "output": {"entities": {"gene": [{"text": "yam8 (+) cDNA", "start": 22, "end": 35}, {"text": "mid1 mutant", "start": 43, "end": 54}]}}, "schema": []}
{"input": "TIP30 has an intrinsic kinase activity required for up-regulation of a subset of apoptotic genes.", "output": {"entities": {"gene": [{"text": "TIP30", "start": 0, "end": 5}]}}, "schema": []}
{"input": "Alternatively, PC12-E2 cells were submitted to treatment with antibodies to the fibroblast growth factor (FGF) receptor, inhibitors of the nonreceptor tyrosine kinase p59 (fyn), PLC, PKC and MEK and an activator of PKC, phorbol-12-myristate-13-acetate (PMA).", "output": {"entities": {"gene": [{"text": "fibroblast growth factor (FGF) receptor", "start": 80, "end": 119}, {"text": "nonreceptor tyrosine kinase p59", "start": 139, "end": 170}, {"text": "fyn", "start": 172, "end": 175}, {"text": "PLC", "start": 178, "end": 181}, {"text": "PKC", "start": 183, "end": 186}, {"text": "MEK", "start": 191, "end": 194}, {"text": "PKC", "start": 215, "end": 218}]}}, "schema": []}
{"input": "Approximately 20% of ALCLs that express ALK do not contain the t (2; 5), suggesting that other genetic abnormalities can result in aberrant ALK expression.", "output": {"entities": {"gene": [{"text": "ALK", "start": 40, "end": 43}, {"text": "ALK", "start": 140, "end": 143}]}}, "schema": []}
{"input": "In addition, expected decreases in ATIC enzymatic function in ATIC-ALK-containing lymphomas may render these tumors more sensitive to antifolate drugs such as methotrexate.", "output": {"entities": {"gene": [{"text": "ATIC", "start": 35, "end": 39}, {"text": "ATIC", "start": 62, "end": 66}, {"text": "ALK", "start": 67, "end": 70}]}}, "schema": []}
{"input": "Manganese ions were found to be essential for autophosphorylation of BGLF4, and magnesium can stimulate the activity.", "output": {"entities": {"gene": [{"text": "BGLF4", "start": 69, "end": 74}]}}, "schema": []}
{"input": "An amino-acid sequence comparison revealed that Bacillus YM55-1 aspartase shared 71% homology with Bacillus subtilis aspartase and 49% with Escherichia coli and Pseudomonas fluorescens aspartases.", "output": {"entities": {"gene": [{"text": "Bacillus YM55-1 aspartase", "start": 48, "end": 73}, {"text": "Bacillus subtilis aspartase", "start": 99, "end": 126}, {"text": "Pseudomonas fluorescens aspartases", "start": 161, "end": 195}]}}, "schema": []}
{"input": "Unique to this system, the activity of TraR is negatively modulated by an antiactivator called TraM.", "output": {"entities": {"gene": [{"text": "TraR", "start": 39, "end": 43}, {"text": "TraM", "start": 95, "end": 99}]}}, "schema": []}
{"input": "As assessed by a genetic assay that measures AAI-dependent DNA binding, TraM inhibited TraR function before and after the transcription factor had bound to its DNA recognition site.", "output": {"entities": {"gene": [{"text": "TraM", "start": 72, "end": 76}, {"text": "TraR", "start": 87, "end": 91}]}}, "schema": []}
{"input": "Collectively, the results suggest that ARF binding to Mdm2 induces a conformational change that facilitates nucleolar import of the ARF-Mdm2 complex and p53-dependent cell cycle arrest.", "output": {"entities": {"gene": [{"text": "ARF", "start": 39, "end": 42}, {"text": "Mdm2", "start": 54, "end": 58}, {"text": "ARF", "start": 132, "end": 135}, {"text": "Mdm2", "start": 136, "end": 140}, {"text": "p53", "start": 153, "end": 156}]}}, "schema": []}
{"input": "The AtERF genes were differentially regulated by ethylene and by abiotic stress conditions, such as wounding, cold, high salinity, or drought, via ETHYLENE-INSENSITIVE2 (EIN2)-dependent or-independent pathways.", "output": {"entities": {"gene": [{"text": "AtERF genes", "start": 4, "end": 15}, {"text": "ETHYLENE-INSENSITIVE2", "start": 147, "end": 168}, {"text": "EIN2", "start": 170, "end": 174}]}}, "schema": []}
{"input": "Electrophoretic mobility shift assays revealed that Sp1 binds to two different regions in the proximal promoter, a typical Sp1 site located at (-38;-33) and a G/C-rich region between (-67;-62).", "output": {"entities": {"gene": [{"text": "Sp1", "start": 52, "end": 55}, {"text": "Sp1 site", "start": 123, "end": 131}]}}, "schema": []}
{"input": "Eight patients received 1. 5 mg of adefovir dipivoxil per kg of body weight, and six patients received 3. 0 mg of adefovir dipivoxil per kg.", "output": {"entities": {}}, "schema": []}
{"input": "Most likely they might represent regulatory RNAs or transcribed transposable elements.", "output": {"entities": {}}, "schema": []}
{"input": "Here we describe the cloning, tissue-specific expression pattern, and functional characterization of two novel TEF-1 isoforms, TEF-1beta and TEF-1gamma.", "output": {"entities": {"gene": [{"text": "TEF-1 isoforms", "start": 111, "end": 125}, {"text": "TEF-1beta", "start": 127, "end": 136}, {"text": "TEF-1gamma", "start": 141, "end": 151}]}}, "schema": []}
{"input": "The comparison of the expression patterns of the known Kv4 family members shows subtype specificity with significant overlaps.", "output": {"entities": {"gene": [{"text": "Kv4 family members", "start": 55, "end": 73}]}}, "schema": []}
{"input": "Preliminary use of the Nottingham Eczema Severity Score would support further development as a research tool for a simple assessment of disease severity that could be used in epidemiological studies.", "output": {"entities": {}}, "schema": []}
{"input": "Advanced adenoma was defined as an adenoma larger than 10 mm or an adenoma of any size with villous component, high-grade dysplasia or invasive carcinoma.", "output": {"entities": {}}, "schema": []}
{"input": "To understand whether Shc localization in membrane rafts is sufficient to regulate Shc function, we constructed a Shc chimera containing the Ras membrane localization motif at the C-terminus.", "output": {"entities": {"gene": [{"text": "Shc", "start": 22, "end": 25}, {"text": "Shc", "start": 83, "end": 86}, {"text": "Shc chimera", "start": 114, "end": 125}, {"text": "Ras membrane localization motif", "start": 141, "end": 172}]}}, "schema": []}
{"input": "RegA is a positive yet nonessential regulator of tol-oprL expression.", "output": {"entities": {"gene": [{"text": "RegA", "start": 0, "end": 4}, {"text": "tol", "start": 49, "end": 52}, {"text": "oprL", "start": 53, "end": 57}]}}, "schema": []}
{"input": "Schlegel, J.", "output": {"entities": {}}, "schema": []}
{"input": "The early dg. of rejection and especially acute rejection, it' s adequate management, decreased risk for the future chronic rejection nephropathy.", "output": {"entities": {}}, "schema": []}
{"input": "Extracellular-regulated kinase (ERK) activation and molecular coupling of the adaptor proteins p130 Crk-associated substrate (CAS) and c-CrkII (Crk) represent two distinct pathways that induce cell invasion and protect cells from apoptosis in a three-dimensional collagen matrix.", "output": {"entities": {"gene": [{"text": "Extracellular-regulated kinase", "start": 0, "end": 30}, {"text": "ERK", "start": 32, "end": 35}, {"text": "p130 Crk-associated substrate", "start": 95, "end": 124}, {"text": "CAS", "start": 126, "end": 129}, {"text": "c-CrkII", "start": 135, "end": 142}, {"text": "Crk", "start": 144, "end": 147}, {"text": "collagen", "start": 263, "end": 271}]}}, "schema": []}
{"input": "The evolution of the CCR5 cis-regulatory region versus the open reading frame as well as among different domains of the open reading frame differed from one another.", "output": {"entities": {"gene": [{"text": "CCR5 cis-regulatory region", "start": 21, "end": 47}]}}, "schema": []}
{"input": "Scanning mutations throughout the AC element interfered with induction but allowed us to define five overlapping sites for regulatory factors in AC and to design probes binding just one or two factors.", "output": {"entities": {}}, "schema": []}
{"input": "Bites by two species of adders (Vipera aspis and Vipera berus) can lead to extensive swelling with multiorgan failure.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSION: Treatment of sepsis with the platelet-activating factor antagonist BB-882 offers no advantage over placebo on survival, hemodynamic status, respiratory function, or organ failure scores.", "output": {"entities": {"gene": [{"text": "platelet-activating factor", "start": 41, "end": 67}]}}, "schema": []}
{"input": "In vivo dimethyl sulfate footprinting of the cyclin E promoter revealed several regions of protection and hypersensitivity that were unique to infected cells.", "output": {"entities": {"gene": [{"text": "cyclin E promoter", "start": 45, "end": 62}]}}, "schema": []}
{"input": "A total of 194 STSs map to this interval of 3 Mb, giving an average marker resolution of approximately one per 15 kb.", "output": {"entities": {}}, "schema": []}
{"input": "Recently, a mutation in the amino-terminus of IB1 was associated with diabetes.", "output": {"entities": {"gene": [{"text": "IB1", "start": 46, "end": 49}]}}, "schema": []}
{"input": "Biol.", "output": {"entities": {}}, "schema": []}
{"input": "These data show that the alpha-helix domain of p57 (Kip2), which is conserved in the Cip/Kip proteins, is implicated in protein-protein interaction and confers a specific regulatory mechanism, outside of their Cdk-inhibitory activity, by which the p57 (Kip2) family members positively act on myogenic differentiation.", "output": {"entities": {"gene": [{"text": "p57", "start": 47, "end": 50}, {"text": "Kip2", "start": 52, "end": 56}, {"text": "Cip", "start": 85, "end": 88}, {"text": "Kip", "start": 89, "end": 92}, {"text": "Cdk", "start": 210, "end": 213}, {"text": "p57", "start": 248, "end": 251}, {"text": "Kip2", "start": 253, "end": 257}]}}, "schema": []}
{"input": "The somatoform conundrum: a question of nosological valves.", "output": {"entities": {}}, "schema": []}
{"input": "Intra-operative ultrasound (IOUS) has been widely used in an attempt to overcome these difficulties, but is limited by its two-dimensional nature, inter-user variability, and image obliteration with ablative or resectional techniques.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSIONS: This randomized study shows that Vivostat fibrin sealant is effective in preventing air leakage after small lung resections in pigs, even at high inspiratory pressures.", "output": {"entities": {"gene": [{"text": "fibrin", "start": 55, "end": 61}]}}, "schema": []}
{"input": "Hailey-Hailey disease is caused by mutations in ATP2C1 encoding a novel Ca (2 +) pump.", "output": {"entities": {"gene": [{"text": "ATP2C1", "start": 48, "end": 54}]}}, "schema": []}
{"input": "A cause of increase of alkaline phosphatase in children", "output": {"entities": {"gene": [{"text": "alkaline phosphatase", "start": 23, "end": 43}]}}, "schema": []}
{"input": "Significantly, two proximal GATA-1-binding sites (-118/-113 and-98/-93) and a region located within-518 to-315bp of the mouse ALAS2 promoter were essential for transcriptional activation during chemically induced differentiation of MEL cells, implying their importance in conferring erythroid specificity to the ALAS2 transcriptional activation.", "output": {"entities": {"gene": [{"text": "GATA-1-binding sites", "start": 28, "end": 48}, {"text": "mouse ALAS2 promoter", "start": 120, "end": 140}, {"text": "ALAS2", "start": 312, "end": 317}]}}, "schema": []}
{"input": "The HMG domain of both HMG20 proteins is most similar to that of yeast NHP6A (38% to 42%).", "output": {"entities": {"gene": [{"text": "HMG domain", "start": 4, "end": 14}, {"text": "HMG20 proteins", "start": 23, "end": 37}, {"text": "yeast NHP6A", "start": 65, "end": 76}]}}, "schema": []}
{"input": "IgM and IgG anti A and anti B antibody status of 100 antenatal O group mothers (who had non O group husbands) were studied.", "output": {"entities": {"gene": [{"text": "IgM", "start": 0, "end": 3}, {"text": "IgG anti A", "start": 8, "end": 18}, {"text": "anti B antibody", "start": 23, "end": 38}]}}, "schema": []}
{"input": "In an attempt to understand Wee1 regulation during cell cycle, yeast two-hybrid screening was used to identify Wee1-binding protein (s).", "output": {"entities": {"gene": [{"text": "Wee1", "start": 28, "end": 32}, {"text": "Wee1-binding protein (s)", "start": 111, "end": 135}]}}, "schema": []}
{"input": "Retroviral transduction of T/T (L) causes a rapidly fatal myeloproliferative disease in a murine bone marrow transplant (BMT) model, whereas T/T (F) causes a long-latency, pre-B-cell lymphoblastic lymphoma.", "output": {"entities": {"gene": [{"text": "T/T (L)", "start": 27, "end": 34}, {"text": "T/T (F)", "start": 141, "end": 148}]}}, "schema": []}
{"input": "The codon usage is particularly marked for the gag, pol, and env genes.", "output": {"entities": {"gene": [{"text": "gag", "start": 47, "end": 50}, {"text": "pol", "start": 52, "end": 55}, {"text": "env genes", "start": 61, "end": 70}]}}, "schema": []}
{"input": "Slap negatively regulates Src mitogenic function but does not revert Src-induced cell morphology changes.", "output": {"entities": {"gene": [{"text": "Slap", "start": 0, "end": 4}, {"text": "Src", "start": 26, "end": 29}, {"text": "Src", "start": 69, "end": 72}]}}, "schema": []}
{"input": "We examine current models of the effects of aging on mean response time and show how they might be reinterpreted.", "output": {"entities": {}}, "schema": []}
{"input": "The effects of these mutations on protein function require further examination.", "output": {"entities": {}}, "schema": []}
{"input": "Kaposi' s sarcoma-associated herpesvirus viral interferon regulatory factor confers resistance to the antiproliferative effect of interferon-alpha.", "output": {"entities": {"gene": [{"text": "viral interferon regulatory factor", "start": 41, "end": 75}, {"text": "interferon-alpha", "start": 130, "end": 146}]}}, "schema": []}
{"input": "AMDA white paper identifies ways to improve pharmaceutical care in SNFs.", "output": {"entities": {}}, "schema": []}
{"input": "Because the mutant defective in DNA binding also fails to stimulate Abf1 ARS1 DNA-binding activity, our results suggest that Cdc6 DNA-binding activity may play a pivotal role in the initiation of DNA replication.", "output": {"entities": {"gene": [{"text": "Abf1", "start": 68, "end": 72}, {"text": "Cdc6", "start": 125, "end": 129}]}}, "schema": []}
{"input": "The structural study of peptides belonging to the terminal domains of histone H1 can be considered as a step toward the understanding of the function of H1 in chromatin.", "output": {"entities": {"gene": [{"text": "histone H1", "start": 70, "end": 80}, {"text": "H1", "start": 153, "end": 155}]}}, "schema": []}
{"input": "The recovery rates for the MB/BacT, MGIT 960, and solid media were 91. 6, 87. 4, and 54. 7%, respectively, for all mycobacteria; the recovery rates were 93. 6, 88. 9, and 63. 4%, respectively, for M. tuberculosis complex alone, and 87. 5, 84. 4, and 37. 5%, respectively, for all nontuberculous mycobacteria.", "output": {"entities": {}}, "schema": []}
{"input": "SELECTION CRITERIA: Randomised and possibly randomised trials using acupuncture to treat asthma and asthma-like symptoms.", "output": {"entities": {}}, "schema": []}
{"input": "SELECTION CRITERIA: Randomised trials comparing children undergoing systematic therapy focusing on the family in conjunction with asthma medication, with children taking asthma medication only.", "output": {"entities": {}}, "schema": []}
{"input": "The models were tested by studying their response to disturbances of the afferent signal from the bladder.", "output": {"entities": {}}, "schema": []}
{"input": "We also show that p65 binds to these targets with almost equal affinity and that different residues have variable roles in binding different kappaB targets.", "output": {"entities": {"gene": [{"text": "p65", "start": 18, "end": 21}, {"text": "kappaB targets", "start": 141, "end": 155}]}}, "schema": []}
{"input": "To illustrate its performance, measurements of photoluminescence in GaAs/AlGaAs heterostructures are presented.", "output": {"entities": {}}, "schema": []}
{"input": "D5/D1 (CT) or D5/D1D (CT) tail substitution mutants displayed a rank order of potency and agonist affinities virtually mimicking wild-type (wt) D1 receptors, as indexed by both ligand binding and dopamine-stimulated cAMP accumulation assays, and, similar to wt D1 receptors, did not exhibit receptor constitutive activity or responsiveness to inverse agonists.", "output": {"entities": {"gene": [{"text": "D5/D1 (CT)", "start": 0, "end": 10}, {"text": "D5/D1D (CT)", "start": 14, "end": 25}, {"text": "wild-type (wt) D1 receptors", "start": 129, "end": 156}, {"text": "D1 receptors", "start": 261, "end": 273}]}}, "schema": []}
{"input": "Modeling also revealed a very hydrophobic surface due to the absence of H12, exposing residues from H3, loop 3-4, H4, and H11.", "output": {"entities": {}}, "schema": []}
{"input": "The immune system is closely integrated with the neuroendocrine system, and infection-induced increases in cytokines such as IL-1, IL-6 and TNF have numerous effects on the central nervous system.", "output": {"entities": {"gene": [{"text": "IL-1", "start": 125, "end": 129}, {"text": "IL-6", "start": 131, "end": 135}, {"text": "TNF", "start": 140, "end": 143}]}}, "schema": []}
{"input": "Flavonoids from Brosimum acutifolium.", "output": {"entities": {}}, "schema": []}
{"input": "Although the OC promoter is activated in a C terminus dependent manner, the MDR, LTR and BSP promoters are repressed by three distinct mechanisms, either independent of or involving the AML C terminus, or requiring only the conserved C-terminal pentapeptide VWRPY.", "output": {"entities": {"gene": [{"text": "OC promoter", "start": 13, "end": 24}, {"text": "MDR", "start": 76, "end": 79}, {"text": "BSP promoters", "start": 89, "end": 102}, {"text": "AML C terminus", "start": 186, "end": 200}]}}, "schema": []}
{"input": "Therefore, analogs of vitamin D3 have been investigated in a number of trials showing improvement of psoriasis.", "output": {"entities": {}}, "schema": []}
{"input": "The network evolution was interpreted by an approach based on the Flory model.", "output": {"entities": {}}, "schema": []}
{"input": "Biologically significant amounts of platelet activating factor were eluted from the sorbent during the entire treatment time.", "output": {"entities": {"gene": [{"text": "platelet activating factor", "start": 36, "end": 62}]}}, "schema": []}
{"input": "Mucin gene expression has been shown to be altered in many intestinal diseases and especially cancers of the gastrointestinal tract.", "output": {"entities": {"gene": [{"text": "Mucin gene", "start": 0, "end": 10}]}}, "schema": []}
{"input": "E2F-1 is a transcription factor that regulates cell cycle progression into S-phase.", "output": {"entities": {"gene": [{"text": "E2F-1", "start": 0, "end": 5}]}}, "schema": []}
{"input": "Taken together, these results indicate that MAP kinase stimulates the hPL-B enhancer by an NF-IL-6-dependent pathway.", "output": {"entities": {"gene": [{"text": "MAP kinase", "start": 44, "end": 54}, {"text": "hPL-B enhancer", "start": 70, "end": 84}, {"text": "NF-IL-6", "start": 91, "end": 98}]}}, "schema": []}
{"input": "Using adenoviral transfer of IkappaBalpha (IkappaBalpha overexpression), the production of TNF-alpha induced by whole GBS was inhibited by only 20%.", "output": {"entities": {"gene": [{"text": "IkappaBalpha", "start": 29, "end": 41}, {"text": "IkappaBalpha", "start": 43, "end": 55}, {"text": "TNF-alpha", "start": 91, "end": 100}]}}, "schema": []}
{"input": "The delta srb10 mutation also influenced on the transcript levels of meiosis-inducing genes called IME1 and IME2: the mutation elevated the transcript level of IME1 but reduced that of IME2, resulting in partial defects in premeiotic DNA synthesis and meiosis.", "output": {"entities": {"gene": [{"text": "delta srb10 mutation", "start": 4, "end": 24}, {"text": "IME1", "start": 99, "end": 103}, {"text": "IME2", "start": 108, "end": 112}, {"text": "IME1", "start": 160, "end": 164}, {"text": "IME2", "start": 185, "end": 189}]}}, "schema": []}
{"input": "We also found that environmental conditions for meiosis finely regulate the transcript levels of KIN28 and CCL1, such that nitrogen starvation first elevates them but subsequent alkalization of medium decreases them.", "output": {"entities": {"gene": [{"text": "KIN28", "start": 97, "end": 102}, {"text": "CCL1", "start": 107, "end": 111}]}}, "schema": []}
{"input": "The effect of acute, mid-cervical spinal cord lesions on neuronal and reflex activity evoked by the noxious visceral stimulus, colorectal distension (CRD; 80 mmHg, 20 s), was determined in halothane-anesthetized rats.", "output": {"entities": {}}, "schema": []}
{"input": "The results suggest that the role of S. argyrostoma in the dissemination of Trichinella larvae in nature is limited in comparison to the role played by mammals with scavenger and cannibalistic behavior.", "output": {"entities": {}}, "schema": []}
{"input": "The equilibrium dissociation binding constant for the interaction of TnrA with the nrgAB promoter fragment was 7. 7 nM under the conditions used here.", "output": {"entities": {"gene": [{"text": "TnrA", "start": 69, "end": 73}, {"text": "nrgAB promoter fragment", "start": 83, "end": 106}]}}, "schema": []}
{"input": "Phd antibody-immunoreactive peptides are seen in light-adapted mouse retinal cytosolic and nuclear extracts.", "output": {"entities": {"gene": [{"text": "Phd", "start": 0, "end": 3}]}}, "schema": []}
{"input": "In contrast to the morphological criteria, the few data available from recent studies at the genetic level have suggested that EPVs infecting different insect orders are phylogenetically distant.", "output": {"entities": {}}, "schema": []}
{"input": "Prevention, differential diagnosis and therapy of travel diarrhea", "output": {"entities": {}}, "schema": []}
{"input": "Mutation analysis demonstrates that the motif TCCCCT is critical for PyRo1 interaction.", "output": {"entities": {"gene": [{"text": "PyRo1", "start": 69, "end": 74}]}}, "schema": []}
{"input": "Our results suggest that proteasome inhibition leads to upregulation of specific members of transcription factor families controlling cellular stress response and proliferation.", "output": {"entities": {}}, "schema": []}
{"input": "In hemodialyzed patients (Epo and Non-Epo group) leptin levels were significantly higher when compared to CAPD patients (Epo and Non-Epo group, respectively).", "output": {"entities": {"gene": [{"text": "Epo", "start": 26, "end": 29}, {"text": "Epo", "start": 38, "end": 41}, {"text": "leptin", "start": 49, "end": 55}, {"text": "Epo", "start": 121, "end": 124}, {"text": "Epo", "start": 133, "end": 136}]}}, "schema": []}
{"input": "ID-PaGIA diphtheria toxin polymer particle diagnostic agent manufactured by DiaMed AG, Switzerland, was tried at bacteriological laboratory of Institute of Childhood Infections in St.", "output": {"entities": {"gene": [{"text": "diphtheria toxin", "start": 9, "end": 25}]}}, "schema": []}
{"input": "Topics reviewed here include: data supporting the association of myositis with cancer and the appropriate evaluations for malignancy in a myositis patient; an approach to the assessment of patients with dermatomyositis sine myositis; the usefulness of the clinicopathological and serological classifications; a discussion of whether childhood and adult myositis are the same or different entities; a review of those prognostic factors to consider in the clinical management of myositis patients; current approaches and their limitations for assessing disease activity and damage.", "output": {"entities": {}}, "schema": []}
{"input": "The outer diameter and the thickness of the rotor are 60 mm and 8 mm, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSIONS: There is a relation in the topography of some visual field areas assessed by SWAP and the inferotemporal neuroretinal rim area, which may play a role in the diagnosis and follow-up of suspected glaucoma.", "output": {"entities": {}}, "schema": []}
{"input": "ACE-2 has a hydrophobic C terminus of H type.", "output": {"entities": {"gene": [{"text": "ACE-2", "start": 0, "end": 5}]}}, "schema": []}
{"input": "We concluded that activation of c-fosER mediated transcriptional inhibition of p21 (Cip1/WAF1) through a previously uncharacterized AP-1 site, revealing an important role for c-fos in negative control of cell cycle regulatory genes.", "output": {"entities": {"gene": [{"text": "c-fosER", "start": 32, "end": 39}, {"text": "p21", "start": 79, "end": 82}, {"text": "Cip1", "start": 84, "end": 88}, {"text": "WAF1", "start": 89, "end": 93}, {"text": "AP-1 site", "start": 132, "end": 141}, {"text": "c-fos", "start": 175, "end": 180}]}}, "schema": []}
{"input": "The first symptoms of enzootic calcinosis were noted in March 1998, when some of the cows developed locomotor abnormalities.", "output": {"entities": {}}, "schema": []}
{"input": "Screening, counseling, and treatment for alcohol and illicit drug use should be essential components in comprehensive HBP care.", "output": {"entities": {}}, "schema": []}
{"input": "Transcriptional regulation of the mouse cytosolic chaperonin subunit gene Ccta/t-complex polypeptide 1 by selenocysteine tRNA gene transcription activating factor family zinc finger proteins.", "output": {"entities": {"gene": [{"text": "mouse cytosolic chaperonin subunit gene Ccta/t-complex polypeptide 1", "start": 34, "end": 102}, {"text": "selenocysteine tRNA gene transcription activating factor family zinc finger proteins", "start": 106, "end": 190}]}}, "schema": []}
{"input": "We have shown that the epidural (EPI) delivery of morphine encapsulated in multivesicular liposomes (DepoFoam drug delivery system) produces a sustained clearance of morphine and a prolonged analgesia.", "output": {"entities": {}}, "schema": []}
{"input": "Following EPI-C0401, but not saline or DepoFoam vehicle, there were transient (< 72 hr) decreases in food consumption, arousal, hindlimb muscle tone, and body temperature.", "output": {"entities": {}}, "schema": []}
{"input": "Resistance ratios for the other field strains obtained by comparison with the R5 strain ranged from 24. 5 to 239 for topical application and from 1. 2 to 9. 8 for the glass jar method.", "output": {"entities": {}}, "schema": []}
{"input": "Reliability of cervical range of motion using the OSI CA 6000 spine motion analyser on asymptomatic and symptomatic subjects.", "output": {"entities": {}}, "schema": []}
{"input": "Activation of PKA by 8-bromo-cyclic AMP or forskolin, and inhibition of PKC by calphostin C, resulted in a significant decrease in 3TP activity as well as in vitro ERK kinase activity in CRAC.", "output": {"entities": {"gene": [{"text": "PKA", "start": 14, "end": 17}, {"text": "PKC", "start": 72, "end": 75}, {"text": "3TP", "start": 131, "end": 134}, {"text": "ERK kinase", "start": 164, "end": 174}]}}, "schema": []}
{"input": "Mus81p also shares homology with motifs found in the XPF endonuclease superfamily.", "output": {"entities": {"gene": [{"text": "Mus81p", "start": 0, "end": 6}, {"text": "XPF endonuclease superfamily", "start": 53, "end": 81}]}}, "schema": []}
{"input": "Double mutant analysis suggests that Rad54p and Mus81p act in one pathway for the repair of, or tolerance to, UV-induced DNA damage.", "output": {"entities": {"gene": [{"text": "Rad54p", "start": 37, "end": 43}, {"text": "Mus81p", "start": 48, "end": 54}]}}, "schema": []}
{"input": "SELECTION CRITERIA: All controlled trials where adults with schizophrenia or similar illnesses were randomised to quetiapine, placebo or other neuroleptic drugs and where clinically relevant outcomes were reported.", "output": {"entities": {}}, "schema": []}
{"input": "Six distinct Ets mRNAs were identified: Ets2, Fli1, GABPalpha, SAP1, Elk1, and PE1.", "output": {"entities": {"gene": [{"text": "Ets mRNAs", "start": 13, "end": 22}, {"text": "Ets2", "start": 40, "end": 44}, {"text": "Fli1", "start": 46, "end": 50}, {"text": "GABPalpha", "start": 52, "end": 61}, {"text": "SAP1", "start": 63, "end": 67}, {"text": "Elk1", "start": 69, "end": 73}, {"text": "PE1", "start": 79, "end": 82}]}}, "schema": []}
{"input": "A 2 kb transcript was isolated from brain that encodes a approximately 57 kDa protein; the predicted protein contains the known N-terminal Ets domain of PE1 and a novel C-terminal domain with signficant homology to murine ERF.", "output": {"entities": {"gene": [{"text": "N-terminal Ets domain", "start": 128, "end": 149}, {"text": "PE1", "start": 153, "end": 156}, {"text": "murine ERF", "start": 215, "end": 225}]}}, "schema": []}
{"input": "Twenty eligible patients with cirrhosis were randomized into two groups: 10 patients treated with 6 million units of natural IFN-beta twice a week for 36 months and 10 patients without IFN therapy.", "output": {"entities": {"gene": [{"text": "IFN-beta", "start": 125, "end": 133}, {"text": "IFN", "start": 185, "end": 188}]}}, "schema": []}
{"input": "It is now well accepted that the p53 C-terminus plays a central role in controlling the activity of the wild-type molecule.", "output": {"entities": {"gene": [{"text": "p53 C-terminus", "start": 33, "end": 47}]}}, "schema": []}
{"input": "The transcription factor Jun (c-Jun) functions as a recipient of extracellular growth signals and converts them into patterns of gene expression.", "output": {"entities": {"gene": [{"text": "Jun", "start": 25, "end": 28}, {"text": "c-Jun", "start": 30, "end": 35}]}}, "schema": []}
{"input": "This compound is the main bioactive metabolite of trimebutine II (Debridat, CAS 39133-31-8), an antispasmodic widely used for intestinal diseases since 1969.", "output": {"entities": {}}, "schema": []}
{"input": "This enabled the formation of stem-loop templates with the fusion point of the chimeric transcript in the loop and the use of MLL primers in two-sided PCR.", "output": {"entities": {"gene": [{"text": "MLL", "start": 126, "end": 129}]}}, "schema": []}
{"input": "It contains 25 exons coding for a 4. 7kb transcript including large 5'-and 3'-(1218bp and 701bp, respectively) untranslated regions (UTRs).", "output": {"entities": {}}, "schema": []}
{"input": "The limit between the cecum and the ascending colon was externally marked by the sulcus cecocolicus dorsalis and ventralis.", "output": {"entities": {}}, "schema": []}
{"input": "These results further support an important role for CBF2 in mediating EBNA2 transactivation; they identify the hnRNP protein AUF1 as a major component of CBF2 and are also the first evidence of a cis-acting sequence other than a CBF1 binding element that is able to confer responsiveness to EBNA2.", "output": {"entities": {"gene": [{"text": "CBF2", "start": 52, "end": 56}, {"text": "EBNA2", "start": 70, "end": 75}, {"text": "hnRNP protein AUF1", "start": 111, "end": 129}, {"text": "CBF2", "start": 154, "end": 158}, {"text": "CBF1 binding element", "start": 229, "end": 249}, {"text": "EBNA2", "start": 291, "end": 296}]}}, "schema": []}
{"input": "Viruses were isolated from 9 lungs: 7 with PI-3V, 1 with NCP BVDV type 1, and 1 with both BVHV-1 and BVDV.", "output": {"entities": {}}, "schema": []}
{"input": "Splicing of the K-SAM alternative exon of the fibroblast growth factor receptor 2 gene is heavily dependent on the U-rich sequence IAS1 lying immediately downstream from its 5' splice site.", "output": {"entities": {"gene": [{"text": "K-SAM", "start": 16, "end": 21}, {"text": "fibroblast growth factor receptor 2 gene", "start": 46, "end": 86}, {"text": "IAS1", "start": 131, "end": 135}]}}, "schema": []}
{"input": "During treatment, the phosphorylation state of Rb shifted to a hypophosphorylated form. mRNA for the HPV E6/E7 genes decreased; however, significant changes in the E7 protein were not observed, while increased levels of Rb immunoprecipitated with anti-E7 antibodies were observed.", "output": {"entities": {"gene": [{"text": "Rb", "start": 47, "end": 49}, {"text": "E6", "start": 105, "end": 107}, {"text": "E7", "start": 108, "end": 110}, {"text": "E7 protein", "start": 164, "end": 174}, {"text": "Rb", "start": 220, "end": 222}, {"text": "anti-E7 antibodies", "start": 247, "end": 265}]}}, "schema": []}
{"input": "Five of the Aeromonas strains and one of V cholerae non-O1 were positive for enterotoxin activity.", "output": {"entities": {}}, "schema": []}
{"input": "The 2 cDNAs differed in the length of their respective 3' untranslated regions, of 577 bp in Cp. F6 and 72 bp in Cp. F10, in both of which a putative polyadenylation signal was identified.", "output": {"entities": {"gene": [{"text": "Cp. F6", "start": 93, "end": 99}, {"text": "Cp. F10", "start": 113, "end": 120}]}}, "schema": []}
{"input": "Platelet counts and function as well as fibrinogen and von Willebrand factor (vWF) levels were determined in each sample.", "output": {"entities": {"gene": [{"text": "fibrinogen", "start": 40, "end": 50}, {"text": "von Willebrand factor", "start": 55, "end": 76}, {"text": "vWF", "start": 78, "end": 81}]}}, "schema": []}
{"input": "The aim of our study was to evaluate the level of oxidative stress in healthy controls (CTL) compared with CRF and HD patients before (pre-HD) and after (post-HD) the dialysis session, carried out on a high biocompatible polyacrylonitrile membrane AN69.", "output": {"entities": {}}, "schema": []}
{"input": "Indirect plasma parameters such as vitamin E, thiol and uric acid levels were also quantified.", "output": {"entities": {}}, "schema": []}
{"input": "The results indicate that the relationship between comprehension and production is different at different stages in development.", "output": {"entities": {}}, "schema": []}
{"input": "On long-term follow-up, there was no significant difference in the incidence of hospitalizations (1 per 2. 1 vs.", "output": {"entities": {}}, "schema": []}
{"input": "The tumor-suppressor protein p53 is involved in maintaining genomic stability.", "output": {"entities": {"gene": [{"text": "tumor-suppressor protein p53", "start": 4, "end": 32}]}}, "schema": []}
{"input": "Abrogation of p53 function by E6 resulted in an increase in the spontaneous mutation frequencies at the heterozygous thymidine kinase (TK) locus but not at the hemizygous hypoxanthine phosphoribosyl transferase (HPRT) locus.", "output": {"entities": {"gene": [{"text": "p53", "start": 14, "end": 17}, {"text": "E6", "start": 30, "end": 32}, {"text": "thymidine kinase", "start": 117, "end": 133}, {"text": "TK", "start": 135, "end": 137}, {"text": "hypoxanthine phosphoribosyl transferase", "start": 171, "end": 210}, {"text": "HPRT", "start": 212, "end": 216}]}}, "schema": []}
{"input": "Cytogenetic analysis of LOH mutants by chromosome painting indicated a mosaic of chromosomal aberrations involving chromosome 17, in which partial chromosome deletions, amplifications, and multiple translocations appeared heterogeneously in a single mutant.", "output": {"entities": {}}, "schema": []}
{"input": "These results support a model in which p53 protein contributes to the maintenance of genomic integrity through recombinational repair.", "output": {"entities": {"gene": [{"text": "p53 protein", "start": 39, "end": 50}]}}, "schema": []}
{"input": "In patients with type II tumors, the pattern of lymphatic spread was primarily directed toward the paracardial, lesser curvature, and left gastric artery nodes; esophagectomy offered no survival benefit over extended gastrectomy in these patients.", "output": {"entities": {}}, "schema": []}
{"input": "The muskox is a new host record for T. gondii.", "output": {"entities": {}}, "schema": []}
{"input": "Mucosal application of NCX-4016, however, did not cause PD reduction and luminal H + loss, but produced a marked hyperemia, resulting in no damage in the stomach of both normal and STZ-diabetic rats.", "output": {"entities": {}}, "schema": []}
{"input": "The amino acid sequence of matrilysin-2 also contains a threonine residue adjacent to the Zn-binding site that has been defined as a specific feature of matrilysin.", "output": {"entities": {"gene": [{"text": "matrilysin-2", "start": 27, "end": 39}, {"text": "matrilysin", "start": 153, "end": 163}]}}, "schema": []}
{"input": "Regarding \" the relation between sexual orientation and penile size, \" by A.", "output": {"entities": {}}, "schema": []}
{"input": "Analysis of Standard Reference Material 1846, Infant Formula, gave a mean value of 0. 95 +/-0. 088 mg vitamin K/kg (K or K1?) (n = 31) with a coefficient of variation of 9. 26.", "output": {"entities": {}}, "schema": []}
{"input": "The Spo0F residues making up the hydrophobic patch are very similar in all response regulators suggesting that the binding is initiated through the same residues in all interacting response regulator-kinase pairs.", "output": {"entities": {"gene": [{"text": "Spo0F residues", "start": 4, "end": 18}]}}, "schema": []}
{"input": "While mutations in K-Rev that inactivate any one of these properties also blocked K-Rev-dependent nuclear RNA export, several K-Rev mutants were comparable to wild type when assayed for any of these individual activities yet nevertheless defective for RNA export.", "output": {"entities": {"gene": [{"text": "K-Rev", "start": 19, "end": 24}, {"text": "K-Rev", "start": 82, "end": 87}, {"text": "K-Rev mutants", "start": 126, "end": 139}]}}, "schema": []}
{"input": "These results suggest that Cdc42p is in fact required for pheromone response and that interaction with the PAK Ste20p is critical for that role.", "output": {"entities": {"gene": [{"text": "Cdc42p", "start": 27, "end": 33}, {"text": "PAK Ste20p", "start": 107, "end": 117}]}}, "schema": []}
{"input": "Symptoms, however, appear to correlate poorly with oesophagitis; hence, severe symptoms do not indicate there is greater oesophageal damage.", "output": {"entities": {}}, "schema": []}
{"input": "The variable phenotype of the allotetraploids could not be explained by cytological abnormalities.", "output": {"entities": {}}, "schema": []}
{"input": "It is now estimated that inactivation mutants of PTEN exist in 60% of all forms of solid tumors.", "output": {"entities": {"gene": [{"text": "PTEN", "start": 49, "end": 53}]}}, "schema": []}
{"input": "We have demonstrated that the activity of ILK is constitutively elevated in PTEN mutant cells.", "output": {"entities": {"gene": [{"text": "ILK", "start": 42, "end": 45}, {"text": "PTEN mutant", "start": 76, "end": 87}]}}, "schema": []}
{"input": "The detector has the advantage of finding both ST segment deviations and entire ST-T complex changes thereby providing a wider characterization of the potential ischemic events.", "output": {"entities": {}}, "schema": []}
{"input": "Primary adrenal hypersensitivity to ACTH drive in obesity has also been suggested.", "output": {"entities": {"gene": [{"text": "ACTH", "start": 36, "end": 40}]}}, "schema": []}
{"input": "In addition, a noncanonical C/EBP-binding site within the Gadd45gamma promoter where C/EBPbeta and C/EBPdelta could bind, was identified by electrophoretic mobility shift assay (EMSA) and reporter gene analysis.", "output": {"entities": {"gene": [{"text": "C/EBP-binding site", "start": 28, "end": 46}, {"text": "Gadd45gamma promoter", "start": 58, "end": 78}, {"text": "C/EBPbeta", "start": 85, "end": 94}, {"text": "C/EBPdelta", "start": 99, "end": 109}]}}, "schema": []}
{"input": "From two inhibitor scaffolds, we have identified potent and selective inhibitors for sensitized kinases from five distinct subfamilies.", "output": {"entities": {}}, "schema": []}
{"input": "By progressive 5'-deletion studies, we have identified a 248-bp DNA fragment (-1018 to-771, relative to the translation start site) at the 5'-flanking region of the human GnRHR gene that is responsible for the GnRHa-mediated down-regulation of human GnRHR promoter activity.", "output": {"entities": {"gene": [{"text": "human GnRHR gene", "start": 165, "end": 181}, {"text": "human GnRHR promoter", "start": 244, "end": 264}]}}, "schema": []}
{"input": "Intracellular localization studies using the mDAP-3/EGFP fusion protein, cell fractionation and protease protection experiments localized mDAP-3 to the mitochondrial matrix.", "output": {"entities": {"gene": [{"text": "mDAP-3", "start": 45, "end": 51}, {"text": "EGFP", "start": 52, "end": 56}, {"text": "mDAP-3", "start": 138, "end": 144}]}}, "schema": []}
{"input": "Reporter gene expression analyses indicate that both WASP promoters show high levels of expression in different hematopoietic cell lines.", "output": {"entities": {"gene": [{"text": "WASP promoters", "start": 53, "end": 67}]}}, "schema": []}
{"input": "Altogether these results suggest that, in KG1a cells, TNFalpha can stimulate in parallel PC-PLC and PLD, whose lipid products activate in turn mitogen-activated protein kinase (MAP kinase) and NF-kappaB signalling respectively.", "output": {"entities": {"gene": [{"text": "TNFalpha", "start": 54, "end": 62}, {"text": "PC-PLC", "start": 89, "end": 95}, {"text": "PLD", "start": 100, "end": 103}, {"text": "mitogen-activated protein kinase", "start": 143, "end": 175}, {"text": "MAP kinase", "start": 177, "end": 187}, {"text": "NF-kappaB", "start": 193, "end": 202}]}}, "schema": []}
{"input": "Polysome and 40S ribosome fractions were severely decreased in the krr1 mutant and Kri1p-depleted cells.", "output": {"entities": {"gene": [{"text": "40S ribosome", "start": 13, "end": 25}, {"text": "krr1 mutant", "start": 67, "end": 78}, {"text": "Kri1p", "start": 83, "end": 88}]}}, "schema": []}
{"input": "They also negatively modulate the PI 3-kinase catalytic activity but to different extents, dependent on the unique N-terminal structure of each isoform.", "output": {"entities": {"gene": [{"text": "PI 3-kinase", "start": 34, "end": 45}]}}, "schema": []}
{"input": "The Drosophila melanogaster suppressor of sable gene, su (s), encodes a novel, 150-kDa nuclear RNA binding protein, SU (S), that negatively regulates RNA accumulation from mutant alleles of other genes that have transposon insertions in the 5' transcribed region.", "output": {"entities": {"gene": [{"text": "Drosophila melanogaster suppressor of sable gene", "start": 4, "end": 52}, {"text": "su (s)", "start": 54, "end": 60}, {"text": "SU (S)", "start": 116, "end": 122}]}}, "schema": []}
{"input": "As a result, we have defined two arginine-rich motifs (ARM1 and ARM2) that mediate the RNA binding activity of SU (S).", "output": {"entities": {"gene": [{"text": "SU (S)", "start": 111, "end": 117}]}}, "schema": []}
{"input": "Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit nuclear factor-kappa B-dependent gene activation at multiple levels in the human monocytic cell line THP-1.", "output": {"entities": {"gene": [{"text": "Vasoactive intestinal peptide", "start": 0, "end": 29}, {"text": "pituitary adenylate cyclase-activating polypeptide", "start": 34, "end": 84}, {"text": "nuclear factor-kappa B-dependent gene", "start": 93, "end": 130}]}}, "schema": []}
{"input": "Overexpression of Trdpm1 in a dpm1 (+):: his7/dpm1 (+) S. pombe diploid resulted in a 4-fold increase in specific DPM synthase activity.", "output": {"entities": {"gene": [{"text": "Trdpm1", "start": 18, "end": 24}, {"text": "dpm1 (+)", "start": 30, "end": 38}, {"text": "his7/dpm1 (+)", "start": 41, "end": 54}, {"text": "DPM synthase", "start": 114, "end": 126}]}}, "schema": []}
{"input": "The N-terminal small segment of yeast TAF145 (yTAF145) binds to TBP and thereby inhibits TBP function.", "output": {"entities": {"gene": [{"text": "yeast TAF145", "start": 32, "end": 44}, {"text": "yTAF145", "start": 46, "end": 53}, {"text": "TBP", "start": 64, "end": 67}, {"text": "TBP", "start": 89, "end": 92}]}}, "schema": []}
{"input": "These probable border sequences are closely related to those of other known T-regions and define a second T-region of pTiChry5, called T-right (TR), that confers production of the Amadoriopines.", "output": {"entities": {}}, "schema": []}
{"input": "Another cis-acting element, exonic splicing suppressor 1 (ESS1), represses use of the nt 3225 3' splice site.", "output": {"entities": {}}, "schema": []}
{"input": "5'-RACE analysis suggested a single transcription initiation site 187 bp upstream from the translational start site.", "output": {"entities": {}}, "schema": []}
{"input": "Thromboelastography is a test that could potentially correlate with the degree of anticoagulation produced by low molecular weight heparin.", "output": {"entities": {}}, "schema": []}
{"input": "Expression of a hybrid protein containing the cytoplasmic C-terminal half of UhpB fused to glutathione S-transferase (GST) also interfered with Uhp signaling.", "output": {"entities": {"gene": [{"text": "UhpB", "start": 77, "end": 81}, {"text": "glutathione S-transferase", "start": 91, "end": 116}, {"text": "GST", "start": 118, "end": 121}, {"text": "Uhp", "start": 144, "end": 147}]}}, "schema": []}
{"input": "RESULTS: Glaucoma suspects were divided into two groups according to their SWAP results: high risk (with SWAP abnormalities) and low risk (with normal SWAP result).", "output": {"entities": {}}, "schema": []}
{"input": "To begin to understand this role, we overexpressed ATF-2 in a human cancer cell line.", "output": {"entities": {"gene": [{"text": "ATF-2", "start": 51, "end": 56}]}}, "schema": []}
{"input": "Botulinum toxin A in the treatment of hemiplegic spastic foot drop--clinical and functional outcomes.", "output": {"entities": {"gene": [{"text": "Botulinum toxin A", "start": 0, "end": 17}]}}, "schema": []}
{"input": "The U17/U16 and the U16 + gene products transactivated the HIV LTR.", "output": {"entities": {"gene": [{"text": "U17", "start": 4, "end": 7}, {"text": "U16", "start": 8, "end": 11}, {"text": "U16 + gene products", "start": 20, "end": 39}, {"text": "HIV LTR", "start": 59, "end": 66}]}}, "schema": []}
{"input": "The Cili-2 sequences possess similarity to the RNaseH domain of Lian-Aa1, a mosquito non-LTR retrotransposon.", "output": {"entities": {"gene": [{"text": "Cili-2 sequences", "start": 4, "end": 20}, {"text": "RNaseH domain", "start": 47, "end": 60}, {"text": "Lian", "start": 64, "end": 68}, {"text": "Aa1", "start": 69, "end": 72}, {"text": "mosquito non-LTR retrotransposon", "start": 76, "end": 108}]}}, "schema": []}
{"input": "This dynamic response strongly suggests that the p53 and Rb tumor suppressor pathways are intact in HeLa cells and that repression of HPV E6 and E7 mobilizes these pathways in an orderly fashion to deliver growth inhibitory signals to the cells.", "output": {"entities": {"gene": [{"text": "p53", "start": 49, "end": 52}, {"text": "Rb", "start": 57, "end": 59}, {"text": "HPV E6", "start": 134, "end": 140}, {"text": "E7", "start": 145, "end": 147}]}}, "schema": []}
{"input": "Effects of spatial and temporal smoothing on stimulated brillouin scattering in the independent-hot-spot model limit The influence of laser beam smoothing on stimulated Brillouin backscattering (SBBS) is studied analytically in the limit of the independent hot spot model.", "output": {"entities": {}}, "schema": []}
{"input": "Association of stress during delivery with increased numbers of nucleated cells and hematopoietic progenitor cells in umbilical cord blood.", "output": {"entities": {}}, "schema": []}
{"input": "Transformation of the sconC3 mutant with sconB + restores the wild-type phenotype.", "output": {"entities": {"gene": [{"text": "sconC3 mutant", "start": 22, "end": 35}, {"text": "sconB +", "start": 41, "end": 48}]}}, "schema": []}
{"input": "RESULTS: The main effect of muscle pain, compared to non-painful stimulation, was a significant and long-lasting increase of delta (1-3 Hz) power and an alpha-1 (9-11 Hz) power increase over the contralateral parietal locus.", "output": {"entities": {}}, "schema": []}
{"input": "Based on 16S rRNA gene sequence analysis, the 11 species having two tuf genes all have a common ancestor, while the six species having only one copy diverged from the enterococcal lineage before that common ancestor.", "output": {"entities": {"gene": [{"text": "16S rRNA gene sequence", "start": 9, "end": 31}, {"text": "tuf genes", "start": 68, "end": 77}]}}, "schema": []}
{"input": "This transcriptional regulation occurs through modulation of the forkhead transcription factor FKHR-L1, and IL-3 inhibited FKHR-L1 activity in a PI3K-dependent manner.", "output": {"entities": {"gene": [{"text": "forkhead transcription factor FKHR-L1", "start": 65, "end": 102}, {"text": "IL-3", "start": 108, "end": 112}, {"text": "FKHR-L1", "start": 123, "end": 130}, {"text": "PI3K", "start": 145, "end": 149}]}}, "schema": []}
{"input": "Taken together, these observations indicate that inhibition of p27 (KIP1) transcription through PI3K-induced FKHR-L1 phosphorylation provides a novel mechanism of regulating cytokine-mediated survival and proliferation.", "output": {"entities": {"gene": [{"text": "p27", "start": 63, "end": 66}, {"text": "KIP1", "start": 68, "end": 72}, {"text": "PI3K", "start": 96, "end": 100}, {"text": "FKHR-L1", "start": 109, "end": 116}]}}, "schema": []}
{"input": "DNase I genomic footprinting revealed that the c-Myb site is occupied in a tissue-specific fashion in vivo.", "output": {"entities": {"gene": [{"text": "DNase I", "start": 0, "end": 7}, {"text": "c-Myb site", "start": 47, "end": 57}]}}, "schema": []}
{"input": "We conclude that c-Myb regulates the RAG-2 promoter in T cells by binding to this consensus c-Myb binding site.", "output": {"entities": {"gene": [{"text": "c-Myb", "start": 17, "end": 22}, {"text": "RAG-2 promoter", "start": 37, "end": 51}, {"text": "consensus c-Myb binding site", "start": 82, "end": 110}]}}, "schema": []}
{"input": "RESULTS: Average age at symptom onset was 41. 2 years.", "output": {"entities": {}}, "schema": []}
{"input": "Unlike the mammalian proteins, XFGF3 is efficiently secreted as a Mr 31, 000 glycoprotein, gp31, which undergoes proteolytic cleavage to produce an NH2-terminally truncated product, gp27.", "output": {"entities": {"gene": [{"text": "XFGF3", "start": 31, "end": 36}, {"text": "gp31", "start": 91, "end": 95}, {"text": "gp27", "start": 182, "end": 186}]}}, "schema": []}
{"input": "NH2-terminal trimming of Xenopus and mammalian FGF3s may therefore be a prerequisite of optimal biological activity.", "output": {"entities": {"gene": [{"text": "mammalian FGF3s", "start": 37, "end": 52}]}}, "schema": []}
{"input": "Here, we identified three cis-elements required for replication within the 200 bp promoter, using autonomously replicating plasmids carrying various mutations and deletions.", "output": {"entities": {}}, "schema": []}
{"input": "The objectives of the present study were to evaluate the effects of adding Equex to a TRIS-extender, diluting the semen in 1 or 2 steps, freezing according to 2 methods, thawing at 2 rates, and the interactions between these treatments, on the post-thaw survival of dog spermatozoa at 38 degrees C.", "output": {"entities": {}}, "schema": []}
{"input": "Molecular cloning and expression of human UDP-d-Xylose: proteoglycan core protein beta-d-xylosyltransferase and its first isoform XT-II.", "output": {"entities": {"gene": [{"text": "human UDP-d-Xylose: proteoglycan core protein beta-d-xylosyltransferase", "start": 36, "end": 107}, {"text": "isoform XT-II", "start": 122, "end": 135}]}}, "schema": []}
{"input": "Oncogenic signalling by E2F1 has recently been linked to stabilization and activation of the tumour suppressor p53 (refs 1, 3, 4).", "output": {"entities": {"gene": [{"text": "E2F1", "start": 24, "end": 28}, {"text": "p53", "start": 111, "end": 114}]}}, "schema": []}
{"input": "We describe the identification and initial characterization of neurobeachin, a neuron-specific multidomain protein of 327 kDa with a high-affinity binding site (K (d), 10 nm) for the type II regulatory subunit of protein kinase A (PKA RII).", "output": {"entities": {"gene": [{"text": "neurobeachin", "start": 63, "end": 75}, {"text": "type II regulatory subunit of protein kinase A", "start": 183, "end": 229}, {"text": "PKA RII", "start": 231, "end": 238}]}}, "schema": []}
{"input": "Antimicrobial Susceptibility of Klebsiella pneumoniae Producing Extended-Spectrum beta-lactamase (ESBL) Isolated in Hospitals in Brazil.", "output": {"entities": {"gene": [{"text": "Extended-Spectrum beta-lactamase", "start": 64, "end": 96}, {"text": "ESBL", "start": 98, "end": 102}]}}, "schema": []}
{"input": "CONCLUSION: Our results suggest that AIF peak saturation leads to a significant systematic error in the determination of CBV and CBF values and has necessarily to be taken into account for dynamic contrast-enhanced MR perfusion studies.", "output": {"entities": {}}, "schema": []}
{"input": "Toward this end, we prepared synthetic proteins with either the catalytic domain of FAP-1 (C-terminal 399 amino acids) or its inactive form (Cys2408--> Ser) fused to glutathione-S-transferase (GST).", "output": {"entities": {"gene": [{"text": "FAP-1 (C-terminal 399 amino acids)", "start": 84, "end": 118}, {"text": "glutathione-S-transferase", "start": 166, "end": 191}, {"text": "GST", "start": 193, "end": 196}]}}, "schema": []}
{"input": "Furthermore, transfection of cells with the spacer-RING domain alone suppressed the antiapoptotic function of the N-terminal BIR domain of c-IAP1 and induced apoptosis.", "output": {"entities": {"gene": [{"text": "BIR", "start": 125, "end": 128}, {"text": "c-IAP1", "start": 139, "end": 145}]}}, "schema": []}
{"input": "MS characteristics of coumarins, psoralens and polymethoxylated flavones with different substitution patterns were determined on the basis of the response obtained with the APcI interface.", "output": {"entities": {}}, "schema": []}
{"input": "Copyright 2000 Academic Press.", "output": {"entities": {}}, "schema": []}
{"input": "Plectin and desmoplakin have GSR-containing domains at their C-termini and we further demonstrate that the GSR-containing domain of plectin, but not desmoplakin, can bind to MTs in vivo.", "output": {"entities": {"gene": [{"text": "Plectin", "start": 0, "end": 7}, {"text": "desmoplakin", "start": 12, "end": 23}, {"text": "plectin", "start": 132, "end": 139}, {"text": "desmoplakin", "start": 149, "end": 160}]}}, "schema": []}
{"input": "Characterization of the microtubule binding domain of microtubule actin crosslinking factor (MACF): identification of a novel group of microtubule associated proteins.", "output": {"entities": {"gene": [{"text": "microtubule actin crosslinking factor", "start": 54, "end": 91}, {"text": "MACF", "start": 93, "end": 97}, {"text": "microtubule associated proteins", "start": 135, "end": 166}]}}, "schema": []}
{"input": "Fecal samples were collected at the beginning and end of each trial period and were analyzed for gastrointestinal nematode eggs and Giardia cyst.", "output": {"entities": {}}, "schema": []}
{"input": "The aim of this study was to determine the risk factors for background diabetic retinopathy (BDR) and PDR by following 394 Japanese patients with early-onset type 2 diabetes diagnosed before 30 years of age (mean age 27, mean blood pressure at entry 116/73 mm Hg).", "output": {"entities": {}}, "schema": []}
{"input": "These cells produced P2Y (11) mRNA during culture.", "output": {"entities": {"gene": [{"text": "P2Y (11) mRNA", "start": 21, "end": 34}]}}, "schema": []}
{"input": "Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex.", "output": {"entities": {"gene": [{"text": "tumor suppressor ING1", "start": 81, "end": 102}, {"text": "mSin3", "start": 112, "end": 117}, {"text": "HDAC1", "start": 118, "end": 123}]}}, "schema": []}
{"input": "As hypothesized, believers showed relatively higher right hemispheric activation and reduced hemispheric asymmetry of functional complexity.", "output": {"entities": {}}, "schema": []}
{"input": "Nucleotide sequence, genome organization and phylogenetic analysis of pineapple mealybug wilt-associated virus-2.", "output": {"entities": {}}, "schema": []}
{"input": "Adjuvant therapy for colon cancer] Surgery alone may fail to cure a considerable number of locally advanced colon cancers.", "output": {"entities": {}}, "schema": []}
{"input": "Effects of Trypanosoma vivax on pregnancy of Yankasa sheep and the results of homidum chloride chemotherapy.", "output": {"entities": {}}, "schema": []}
{"input": "NF kappa B was activated to a much greater extent by roscovitine in the WT cells than in Y8 cells.", "output": {"entities": {"gene": [{"text": "NF kappa B", "start": 0, "end": 10}]}}, "schema": []}
{"input": "Additionally, MIP-2A antagonizes cell growth regulatory role of MBP-1.", "output": {"entities": {"gene": [{"text": "MIP-2A", "start": 14, "end": 20}, {"text": "MBP-1", "start": 64, "end": 69}]}}, "schema": []}
{"input": "3. 04 +/-1. 2, P < 0. 0001), large accelerations/30 min (1. 46 +/-1. 96 vs.", "output": {"entities": {}}, "schema": []}
{"input": "In addition, we identified two mutations, Delta M1281 and IVS51 + 5G--> A, in a German USH1 patient.", "output": {"entities": {"gene": [{"text": "USH1", "start": 87, "end": 91}]}}, "schema": []}
{"input": "Nuclease probing and structure-directed mutagenesis revealed that the 105-nt TE (TE105) forms a cruciform secondary structure containing four helices connected by single-stranded regions.", "output": {"entities": {}}, "schema": []}
{"input": "Tele-Talk has the extra capability of operating in live conference situations using microphone input.", "output": {"entities": {}}, "schema": []}
{"input": "Perfusion technique for perfusion-assisted direct coronary artery bypass (PADCAB).", "output": {"entities": {}}, "schema": []}
{"input": "As well, mixtures of (LA) (12) with the longer chain PEs exhibit unusual biomodal enthalpy variations, suggesting peptide immiscibility in thicker gel state bilayers.", "output": {"entities": {}}, "schema": []}
{"input": "Energy expenditure was obtained using a primed, 3-hour infusion of NaH (13) CO (3'), breath (13) CO (2) enrichment determination by isotope ratio mass spectroscopy, and the application of a standard regression equation.", "output": {"entities": {}}, "schema": []}
{"input": "Workload, UAPs, and you.", "output": {"entities": {}}, "schema": []}
{"input": "Naltrexone hydrochloride is a synthetic opioid receptor antagonist recently used in efforts to provide rapid opioid detoxification.", "output": {"entities": {"gene": [{"text": "opioid receptor", "start": 40, "end": 55}]}}, "schema": []}
{"input": "Derivation and initial characterization of a mouse mammary tumor cell line carrying the polyomavirus middle T antigen: utility in the development of novel cancer therapeutics.", "output": {"entities": {"gene": [{"text": "polyomavirus middle T antigen", "start": 88, "end": 117}]}}, "schema": []}
{"input": "Hypomorphic dSLBP alleles support zygotic development but cause female sterility.", "output": {"entities": {"gene": [{"text": "dSLBP alleles", "start": 12, "end": 25}]}}, "schema": []}
{"input": "We mapped the DGCR6 gene to chromosome 22q11 within a low copy repeat, termed sc11. 1a, and identified a second copy of the gene, DGCR6L, within the duplicate locus, termed sc11. 1b.", "output": {"entities": {"gene": [{"text": "DGCR6 gene", "start": 14, "end": 24}, {"text": "DGCR6L", "start": 130, "end": 136}]}}, "schema": []}
{"input": "Recruitment of an RNA polymerase II complex is mediated by the constitutive activation domain in CREB, independently of CREB phosphorylation.", "output": {"entities": {"gene": [{"text": "RNA polymerase II complex", "start": 18, "end": 43}, {"text": "CREB", "start": 97, "end": 101}, {"text": "CREB", "start": 120, "end": 124}]}}, "schema": []}
{"input": "The observed phenotypes may be explained by (i) a selective disruption of very-low-density lipoprotein secretion due to decreased expression of genes encoding apolipoprotein B and microsomal triglyceride transfer protein, (ii) an increase in hepatic cholesterol uptake due to increased expression of the major high-density lipoprotein receptor, scavenger receptor BI, and (iii) a decrease in bile acid uptake to the liver due to down-regulation of the major basolateral bile acid transporters sodium taurocholate cotransporter protein and organic anion transporter protein 1.", "output": {"entities": {"gene": [{"text": "very-low-density lipoprotein", "start": 74, "end": 102}, {"text": "apolipoprotein B", "start": 159, "end": 175}, {"text": "microsomal triglyceride transfer protein", "start": 180, "end": 220}, {"text": "high-density lipoprotein receptor", "start": 310, "end": 343}, {"text": "scavenger receptor BI", "start": 345, "end": 366}, {"text": "basolateral bile acid transporters sodium taurocholate cotransporter protein", "start": 458, "end": 534}, {"text": "organic anion transporter protein 1", "start": 539, "end": 574}]}}, "schema": []}
{"input": "Inactivity of the human cytomegalovirus (HCMV) major immediate-early regulatory region (MIERR), which is composed of promoter, enhancer, unique region, and modulator, is linked to lack of HCMV replication in latently infected cells and in other nonpermissive cell types, including human embryonal NTera2 carcinoma (NT2) cells.", "output": {"entities": {"gene": [{"text": "human cytomegalovirus (HCMV) major immediate-early regulatory region", "start": 18, "end": 86}, {"text": "MIERR", "start": 88, "end": 93}]}}, "schema": []}
{"input": "Both Z and R expression resulted in PML dispersion in EBV-positive cells.", "output": {"entities": {"gene": [{"text": "Z", "start": 5, "end": 6}, {"text": "R", "start": 11, "end": 12}]}}, "schema": []}
{"input": "Immunofluorescence studies in C2C12 myotubes show that Smad2 and MEF2A co-localise in the nucleus of multinuclear myotubes during differentiation.", "output": {"entities": {"gene": [{"text": "Smad2", "start": 55, "end": 60}, {"text": "MEF2A", "start": 65, "end": 70}]}}, "schema": []}
{"input": "Southern blot analysis of genomic DNA from somatic cell hybrids showed that endothelial-TACC-related cDNA maps to chromosome 10.", "output": {"entities": {"gene": [{"text": "endothelial-TACC-related cDNA", "start": 76, "end": 105}]}}, "schema": []}
{"input": "The presence of truncated receptor isoforms in diverse species suggests that these proteins may have important functional roles in regulating EGFR activity.", "output": {"entities": {"gene": [{"text": "EGFR", "start": 142, "end": 146}]}}, "schema": []}
{"input": "The continuing development of ligands that function as selective estrogens or antiestrogens for ERalpha or ERbeta should allow optimized tissue selectivity of these agents for menopausal hormone replacement therapy and the treatment and prevention of breast cancer.", "output": {"entities": {"gene": [{"text": "ERalpha", "start": 96, "end": 103}, {"text": "ERbeta", "start": 107, "end": 113}]}}, "schema": []}
{"input": "Behavioural tests with 192 specimen of the roman garden snail Helix pomatia L. were performed in order to clarify whether the thermopreferendum of this pulmonate is influenced not only by the temperature of the substratum but also by air temperature.", "output": {"entities": {}}, "schema": []}
{"input": "Increased erythropoietin synthesis in patients with COLD or left heart failure is related to alterations in renal haemodynamics.", "output": {"entities": {"gene": [{"text": "erythropoietin", "start": 10, "end": 24}]}}, "schema": []}
{"input": "Using immunochemical co-precipitation methods, we also found that the two proteins are bound in vivo.", "output": {"entities": {}}, "schema": []}
{"input": "An additional 9 patients achieved normal levels with adjunctive drug therapy.", "output": {"entities": {}}, "schema": []}
{"input": "For immunological methods, identification of such antigens with intermolecular variability, e. g., the structural aescin analogs, is of unknown validity.", "output": {"entities": {}}, "schema": []}
{"input": "Blood from dams was collected prior to inoculation and at time of necropsy for measurement of IgM and IgG antibodies to M. pulmonis.", "output": {"entities": {"gene": [{"text": "IgM", "start": 94, "end": 97}, {"text": "IgG antibodies", "start": 102, "end": 116}]}}, "schema": []}
{"input": "Single amino acid substitutions at the acyl-CoA-binding domain interrupt 14 [C] palmitoyl-CoA binding of ACBP2, an Arabidopsis acyl-CoA-binding protein with ankyrin repeats.", "output": {"entities": {"gene": [{"text": "ACBP2", "start": 105, "end": 110}, {"text": "acyl-CoA-binding protein", "start": 127, "end": 151}, {"text": "ankyrin", "start": 157, "end": 164}]}}, "schema": []}
{"input": "The bovine PGHS-2 cDNA was cloned by a combination of reverse transcription-polymerase chain reaction and cDNA library screening.", "output": {"entities": {"gene": [{"text": "bovine PGHS-2 cDNA", "start": 4, "end": 22}]}}, "schema": []}
{"input": "The regulation of PGHS-2 mRNA and protein was studied in primary cultures of bovine uterine stromal cells stimulated with phorbol 12-myristate 13-acetate (PMA; 100 nM).", "output": {"entities": {"gene": [{"text": "PGHS-2 mRNA", "start": 18, "end": 29}]}}, "schema": []}
{"input": "Anti-nucleolin mAb was used to confirm the antigenic properties of this p95 component.", "output": {"entities": {"gene": [{"text": "Anti-nucleolin mAb", "start": 0, "end": 18}, {"text": "p95 component", "start": 72, "end": 85}]}}, "schema": []}
{"input": "Furthermore, stable expression of a constitutively active form of chicken Notch1 or Notch2 in a B cell line results in a down-regulation of surface IgM expression, which is accompanied by the reduction of IgH gene transcripts.", "output": {"entities": {"gene": [{"text": "Notch1", "start": 74, "end": 80}, {"text": "Notch2", "start": 84, "end": 90}, {"text": "IgM", "start": 148, "end": 151}, {"text": "IgH gene transcripts", "start": 205, "end": 225}]}}, "schema": []}
{"input": "The effects of the transfected receptors were associated with antagonism of activator protein 1 (AP-1) activity.", "output": {"entities": {"gene": [{"text": "activator protein 1", "start": 76, "end": 95}, {"text": "AP-1", "start": 97, "end": 101}]}}, "schema": []}
{"input": "Recent studies using isolated rat adipocytes and chemically synthesized PIG compounds point to IRS1/3 tyrosine phosphorylation by p59Lyn kinase as the site of cross-talk, the negative regulation of which by interaction with caveolin is apparently abrogated by PIG.", "output": {"entities": {"gene": [{"text": "IRS1/3", "start": 95, "end": 101}, {"text": "p59Lyn kinase", "start": 130, "end": 143}, {"text": "caveolin", "start": 224, "end": 232}]}}, "schema": []}
{"input": "As an oral, nontoxic compound with a mechanism of action distinct from that of ABL tyrosine kinase inhibition, FTI SCH66336 shows promise for the treatment of BCR/ABL-induced leukemia.", "output": {"entities": {"gene": [{"text": "ABL tyrosine kinase", "start": 79, "end": 98}, {"text": "BCR", "start": 159, "end": 162}, {"text": "ABL", "start": 163, "end": 166}]}}, "schema": []}
{"input": "We conclude that RPMS acts as a negative regulator of EBNA2 and Notch activity through its interactions with the CBF1-associated corepressor complex.", "output": {"entities": {"gene": [{"text": "RPMS", "start": 17, "end": 21}, {"text": "EBNA2", "start": 54, "end": 59}, {"text": "Notch", "start": 64, "end": 69}, {"text": "CBF1-associated corepressor complex", "start": 113, "end": 148}]}}, "schema": []}
{"input": "Transactivation of oIFNtau enhancer-reporter constructs was primarily regulated by three regions containing AP-1 site, GATA like sequence and site (s) unidentified.", "output": {"entities": {"gene": [{"text": "oIFNtau", "start": 19, "end": 26}, {"text": "AP-1 site", "start": 108, "end": 117}, {"text": "GATA like sequence", "start": 119, "end": 137}]}}, "schema": []}
{"input": "Copyright 2000 John Wiley & Sons, Ltd.", "output": {"entities": {}}, "schema": []}
{"input": "Fluorimetric determination of methylmercury as an ion-association complex with rhodamine B in the presence of iodide.", "output": {"entities": {}}, "schema": []}
{"input": "Cells containing alpha subunits that lacked a distal domain (term-3) or had the alternatively spliced alpha-2 distal domain showed markedly decreased ability to support tyrosine phosphorylation of Jak-2 and its substrates or to up-regulate CD86.", "output": {"entities": {"gene": [{"text": "Jak-2", "start": 197, "end": 202}, {"text": "CD86", "start": 240, "end": 244}]}}, "schema": []}
{"input": "In Saccharomyces cerevisiae, eIF6 is encoded by a single-copy essential gene.", "output": {"entities": {"gene": [{"text": "eIF6", "start": 29, "end": 33}]}}, "schema": []}
{"input": "TaqMan analysis of gene expression following chronic FA treatment showed neither a decrease in the amount of leptin receptor (Ob-R) mRNA, nor an increase in the negative regulators of STAT signalling, SOCS3 (suppressors of cytokine signalling) or cytokine inducible sequence (CIS).", "output": {"entities": {"gene": [{"text": "leptin receptor", "start": 109, "end": 124}, {"text": "Ob-R", "start": 126, "end": 130}, {"text": "STAT", "start": 184, "end": 188}, {"text": "SOCS3", "start": 201, "end": 206}, {"text": "suppressors of cytokine signalling", "start": 208, "end": 242}, {"text": "cytokine inducible sequence", "start": 247, "end": 274}, {"text": "CIS", "start": 276, "end": 279}]}}, "schema": []}
{"input": "The blood levels of lactate, pyruvate and amino acids were not elevated.", "output": {"entities": {}}, "schema": []}
{"input": "The expression of alpha-amylase can be transactivated by the transcription factor GAMyb, which is itself induced by GA.", "output": {"entities": {"gene": [{"text": "alpha-amylase", "start": 18, "end": 31}, {"text": "GAMyb", "start": 82, "end": 87}]}}, "schema": []}
{"input": "Only nine patients were offered surgery (six were resected and three were found inoperable).", "output": {"entities": {}}, "schema": []}
{"input": "Adjuvant and neoadjuvant treatment of breast cancer.", "output": {"entities": {}}, "schema": []}
{"input": "Sequence analysis revealed significant differences between the 5' region of the beta subunit gene and the corresponding regions of the homologous GlyR alpha subunit genes; it also identified a novel exon (exon 0) that encodes most of the 5'-untranslated portion of the GlyR beta mRNA.", "output": {"entities": {"gene": [{"text": "homologous GlyR alpha subunit genes", "start": 135, "end": 170}, {"text": "GlyR beta mRNA", "start": 269, "end": 283}]}}, "schema": []}
{"input": "Anecdotal observations scattered throughout the literature have often provided clues to underlying variations in humans' ability to handle dietary chemicals.", "output": {"entities": {}}, "schema": []}
{"input": "The human cytomegalovirus (HCMV) major immediate-early protein IE2 is a nuclear phosphoprotein that is believed to be a key regulator in both lytic and latent infections.", "output": {"entities": {"gene": [{"text": "human cytomegalovirus (HCMV) major immediate-early protein IE2", "start": 4, "end": 66}]}}, "schema": []}
{"input": "OBJECTIVE: To determine whether RSTD predicts coronary anatomy during acute coronary occlusion.", "output": {"entities": {}}, "schema": []}
{"input": "We have now tested all known mammalian Groucho family members for their ability to interact specifically with individual Tcf/Lef family members.", "output": {"entities": {"gene": [{"text": "mammalian Groucho family members", "start": 29, "end": 61}, {"text": "Tcf", "start": 121, "end": 124}, {"text": "Lef", "start": 125, "end": 128}]}}, "schema": []}
{"input": "We show here that the in vitro transcription extract contains a binding activity that is specific for the initiator element and thus may participate in recruiting RNA polymerase II to the SL RNA gene promoter.", "output": {"entities": {"gene": [{"text": "RNA polymerase II", "start": 163, "end": 180}]}}, "schema": []}
{"input": "The 438 bp EcoRI fragment, which was detected by Southern hybridization, reveals an open reading frame which encodes a protein of 103 amino acids.", "output": {"entities": {"gene": [{"text": "438 bp EcoRI fragment", "start": 4, "end": 25}]}}, "schema": []}
{"input": "Furthermore, this kinase-deficient mutant inhibited 2-MeSADP-induced caspase-3 stimulation and the associated decrease in cell number.", "output": {"entities": {"gene": [{"text": "caspase-3", "start": 69, "end": 78}]}}, "schema": []}
{"input": "A 20-base pair oligonucleotide containing this nonamer confers up-regulation by hypoxia and inhibition by unsaturated fatty acids when placed upstream of a heterologous promoter in a lacZ reporter construct.", "output": {"entities": {"gene": [{"text": "lacZ reporter construct", "start": 183, "end": 206}]}}, "schema": []}
{"input": "Deletion analyses implicate the N-terminal 110 amino acids of Grb14 and ankyrin repeats 10-19 of tankyrase 2 in mediating this interaction.", "output": {"entities": {"gene": [{"text": "Grb14", "start": 62, "end": 67}, {"text": "ankyrin", "start": 72, "end": 79}, {"text": "tankyrase 2", "start": 97, "end": 108}]}}, "schema": []}
{"input": "Finally a 10-nucleotide region flanking the exon 4 protein-binding site is homologous to instability elements within five other transcripts, suggesting that a common coding region determinant may exist.", "output": {"entities": {}}, "schema": []}
{"input": "Analysis of regulatory regions in the promoter of the ctr4 (+) copper transporter gene in fission yeast Schizosaccharomyces pombe reveals the identity of a conserved copper-signaling element (CuSE), which is recognized by the transcription factor Cuf1.", "output": {"entities": {"gene": [{"text": "ctr4 (+) copper transporter gene", "start": 54, "end": 86}, {"text": "transcription factor Cuf1", "start": 226, "end": 251}]}}, "schema": []}
{"input": "WRN helicase resolves alternate DNA structures including tetraplex and triplex DNA, and Holliday junctions.", "output": {"entities": {"gene": [{"text": "WRN helicase", "start": 0, "end": 12}]}}, "schema": []}
{"input": "These data suggest that ADAM-TS12 may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion.", "output": {"entities": {"gene": [{"text": "ADAM-TS12", "start": 24, "end": 33}]}}, "schema": []}
{"input": "Biol.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSIONS: Using icodextrin-based instead of glucose-based PD fluids can largely reduce the formation of Amadori albumin and AGEs.", "output": {"entities": {"gene": [{"text": "albumin", "start": 115, "end": 122}]}}, "schema": []}
{"input": "In contrast, exogenous PTHrP1-34 and 1-86 peptides did not significantly affect IL-8 production; moreover, PTHrP-neutralizing antibodies did not inhibit the production of IL-8 by transfected PTHrP.", "output": {"entities": {"gene": [{"text": "exogenous PTHrP1-34 and 1-86 peptides", "start": 13, "end": 50}, {"text": "IL-8", "start": 80, "end": 84}, {"text": "PTHrP-neutralizing antibodies", "start": 107, "end": 136}, {"text": "IL-8", "start": 171, "end": 175}, {"text": "PTHrP", "start": 191, "end": 196}]}}, "schema": []}
{"input": "Our results suggest that WASP activates transcription following TCR stimulation in a manner that is independent of its role in Arp2/3-directed actin polymerization.", "output": {"entities": {"gene": [{"text": "WASP", "start": 25, "end": 29}, {"text": "TCR", "start": 64, "end": 67}, {"text": "Arp2/3", "start": 127, "end": 133}, {"text": "actin", "start": 143, "end": 148}]}}, "schema": []}
{"input": "These data define a conserved pathway wherein sequential histone modifications establish a \" histone code \" essential for the epigenetic inheritance of heterochromatin assembly.", "output": {"entities": {"gene": [{"text": "histone", "start": 57, "end": 64}, {"text": "histone", "start": 93, "end": 100}]}}, "schema": []}
{"input": "The Delta6CCI virus was extremely attenuated in replication capacity yet retained infectiousness for CEMx174 and MT4 cells.", "output": {"entities": {}}, "schema": []}
{"input": "PABP is a modular protein, with four N-terminal RNA-binding domains and an extensive C terminus.", "output": {"entities": {"gene": [{"text": "PABP", "start": 0, "end": 4}]}}, "schema": []}
{"input": "In addition, another derivative of pCMVJS21 (pCMVJS21DeltaGP) in which the gag, pol (and orf-x) coding sequences were deleted also gave transformed foci.", "output": {"entities": {"gene": [{"text": "gag", "start": 75, "end": 78}, {"text": "pol", "start": 80, "end": 83}, {"text": "orf-x", "start": 89, "end": 94}]}}, "schema": []}
{"input": "In contrast, neither I. argentina nor I. theezans exerted any effect on BF or intestinal propulsion.", "output": {"entities": {}}, "schema": []}
{"input": "These data reveal a complex network of interactions between GTPases in the ARF family and their effectors and reveal a potential for cross-talk not demonstrated previously.", "output": {"entities": {"gene": [{"text": "GTPases", "start": 60, "end": 67}, {"text": "ARF family", "start": 75, "end": 85}]}}, "schema": []}
{"input": "A mutation in the C domain of Rb, L901Q, has been identified that completely abolishes cdk4/D1 phosphorylation of the isolated C domain.", "output": {"entities": {"gene": [{"text": "Rb", "start": 30, "end": 32}, {"text": "cdk4", "start": 87, "end": 91}, {"text": "D1", "start": 92, "end": 94}]}}, "schema": []}
{"input": "We previously showed that this proteolysis 1) can be acutely promoted by the phorbol ester phorbol 12-myristate 13-acetate (PMA), 2) requires a metalloprotease activity, 3) generates both shed GHBP and a membrane-associated GHR transmembrane/cytoplasmic domain remnant, and 4) results in down-regulation of GHR abundance and GH signaling.", "output": {"entities": {"gene": [{"text": "metalloprotease", "start": 144, "end": 159}, {"text": "GHBP", "start": 193, "end": 197}, {"text": "membrane-associated GHR transmembrane/cytoplasmic domain", "start": 204, "end": 260}, {"text": "GHR", "start": 307, "end": 310}, {"text": "GH", "start": 325, "end": 327}]}}, "schema": []}
{"input": "These disorders include low-back pain, saddle anesthesia, bilateral sciatica, then motor weakness of the lower extremities or chronic paraplegia and, bladder dysfunction.", "output": {"entities": {}}, "schema": []}
{"input": "Sural nerve biopsy showed mild thickening of the perineurium, vascular alterations with inflammatory cell infiltration in the perineurium, and remarkable loss of large and small myelinated fibers.", "output": {"entities": {}}, "schema": []}
{"input": "When this CCAAT box was inserted into a heterologous promoter construct, OA induction was dependent on an intact CCAAT box.", "output": {"entities": {}}, "schema": []}
{"input": "The JHRLSS has been used in prior studies to assess RLS severity, but has not previously been validated in relation to direct measures of the morbidity associated with RLS.", "output": {"entities": {}}, "schema": []}
{"input": "Our results suggest that the C-terminal region of Crk contains negative regulatory elements important for both Abl and FAK dependent signal pathways, and offers a paradigm for an autoinhibitory region in the SH3 linker/C-terminal SH3 domain.", "output": {"entities": {"gene": [{"text": "Crk", "start": 50, "end": 53}, {"text": "Abl", "start": 111, "end": 114}, {"text": "FAK", "start": 119, "end": 122}, {"text": "SH3", "start": 208, "end": 211}, {"text": "SH3", "start": 230, "end": 233}]}}, "schema": []}
{"input": "This unique location of cavernous malformation is associated with a risk of permanent loss of the vision.", "output": {"entities": {}}, "schema": []}
{"input": "The MSL complex is specifically localized on the male X chromosome to increase its expression approximately 2-fold.", "output": {"entities": {"gene": [{"text": "MSL complex", "start": 4, "end": 15}]}}, "schema": []}
{"input": "Consistent effects on pVHL function were observed for all mutations within each subclass.", "output": {"entities": {"gene": [{"text": "pVHL", "start": 22, "end": 26}]}}, "schema": []}
{"input": "Here, we identify Rsc3 and Rsc30 as novel components of the essential yeast remodeler RSC complex.", "output": {"entities": {"gene": [{"text": "Rsc3", "start": 18, "end": 22}, {"text": "Rsc30", "start": 27, "end": 32}, {"text": "yeast remodeler RSC complex", "start": 70, "end": 97}]}}, "schema": []}
{"input": "Early indicators of the effect of a breast cancer screening program for low-income women.", "output": {"entities": {}}, "schema": []}
{"input": "Linear eight-or nine-residue D-peptides derived from the pocket-binding domain of the cyclic molecules also bind specifically.", "output": {"entities": {}}, "schema": []}
{"input": "Here we present evidence that the distal half (Stem 2) of the conserved base-paired stem structure found in all hY RNAs also plays a critical role in the export process.", "output": {"entities": {"gene": [{"text": "hY RNAs", "start": 112, "end": 119}]}}, "schema": []}
{"input": "Here we provide the first evidence for the involvement of GCN1-GCN2 interaction in activation of GCN2 per se.", "output": {"entities": {"gene": [{"text": "GCN1", "start": 58, "end": 62}, {"text": "GCN2", "start": 63, "end": 67}, {"text": "GCN2", "start": 97, "end": 101}]}}, "schema": []}
{"input": "Expression of human RACK1 efficiently relieves E1A-mediated growth inhibition in HF7c and protects human tumor cells from E1A-induced apoptosis.", "output": {"entities": {"gene": [{"text": "human RACK1", "start": 14, "end": 25}, {"text": "E1A", "start": 47, "end": 50}, {"text": "E1A", "start": 122, "end": 125}]}}, "schema": []}
{"input": "Molecular analysis of the pRA2 partitioning region: ParB autoregulates parAB transcription and forms a nucleoprotein complex with the plasmid partition site, parS.", "output": {"entities": {"gene": [{"text": "ParB", "start": 52, "end": 56}, {"text": "parAB", "start": 71, "end": 76}, {"text": "parS", "start": 158, "end": 162}]}}, "schema": []}
{"input": "SERS spectra were obtained by vacuum evaporation and casting of p-NTP onto silver island films, and also from colloidal silver solutions.", "output": {"entities": {}}, "schema": []}
{"input": "Copyright 2001 Academic Press.", "output": {"entities": {}}, "schema": []}
{"input": "These corrections do not involve sequences predicted to function as transcription factor binding sites.", "output": {"entities": {}}, "schema": []}
{"input": "A patient is described with skin lesions resembling Kaposi' s sarcoma (KS).", "output": {"entities": {}}, "schema": []}
{"input": "The images showed rapid, predominantly urinary excretion of 99mTc ciprofloxacin, with low to absent brain, lung and bone marrow uptake and low liver uptake and excretion.", "output": {"entities": {}}, "schema": []}
{"input": "To this end, an expression cassette consisting of the gene for a green fluorescent protein (GFP) flanked at its 3' end by EAV-specific transcription-regulating sequences was constructed.", "output": {"entities": {"gene": [{"text": "green fluorescent protein", "start": 65, "end": 90}, {"text": "GFP", "start": 92, "end": 95}]}}, "schema": []}
{"input": "In addition, severe vision loss can be seen with interferon alfa-2b-associated retinopathy.", "output": {"entities": {"gene": [{"text": "interferon alfa-2b", "start": 49, "end": 67}]}}, "schema": []}
{"input": "The mechanism of the induction of 3beta-HSD type 1 gene expression was further characterized in ZR-75-1 human breast cancer cells.", "output": {"entities": {"gene": [{"text": "3beta-HSD type 1 gene", "start": 34, "end": 55}]}}, "schema": []}
{"input": "The application of the biotechnology at the plants for treatment of the surface storm waters from the industrial zone Telychka of the city of Kyiv has allowed the content of petroleum in water dropped to the Dnieper to be constantly reduced 50-100 times.", "output": {"entities": {}}, "schema": []}
{"input": "Fans in tunnels and open windows at aboveground locations appeared to greatly reduce the likelihood of high PH3 concentrations in enclosed areas.", "output": {"entities": {}}, "schema": []}
{"input": "The first case of HCV seroconversion in Portugal after the introduction of HCV NAT screening.", "output": {"entities": {}}, "schema": []}
{"input": "The observed triplexes depend on the length of the repeat.", "output": {"entities": {}}, "schema": []}
{"input": "We used stored plasma samples from 409 patients in the National Institute of Neurological Diseases and Stroke (NINDS) tissue plasminogen activator (t-PA) Stroke Trial to examine the relationship between an apolipoprotein (Apo) E2 or an Apo E4 phenotype and a favorable outcome 3 months after stroke, the risk of intracerebral hemorrhage, and the response to intravenous t-PA therapy.", "output": {"entities": {"gene": [{"text": "tissue plasminogen activator", "start": 118, "end": 146}, {"text": "t-PA", "start": 148, "end": 152}, {"text": "apolipoprotein (Apo) E2", "start": 206, "end": 229}, {"text": "Apo E4", "start": 236, "end": 242}, {"text": "t-PA", "start": 370, "end": 374}]}}, "schema": []}
{"input": "Colorectal cancer was shown to disproportionately overburden Ashkenazi Jews, who may also be at increased risk for ovarian, pancreatic and stomach cancer, and non-Hodgkin' s lymphoma.", "output": {"entities": {}}, "schema": []}
{"input": "RANTES (regulated upon activation, normally T-cell expressed and presumably secreted) is a CC chemokine which recruits and activates monocytes, lymphocytes, and eosinophils, all cell types present in the lung inflammatory infiltrate induced by RSV infection.", "output": {"entities": {"gene": [{"text": "RANTES", "start": 0, "end": 6}, {"text": "regulated upon activation, normally T-cell expressed and presumably secreted", "start": 8, "end": 84}]}}, "schema": []}
{"input": "Five modalities of nonpharmacologic approaches are recommended at present for lifestyle modification and control of arterial blood pressure elevation: 1) weight reduction to ideal body weight, since it reduces risk of hypertension as well as overall cardiovascular morbidity and mortality; 2) dietary sodium restriction to less than 2 g a day, without assurance that it will normalize arterial pressure although it may help reduce dosage and numbers of prescribed antihypertensive drugs; 3) moderation of alcohol consumption to less than 1 ounce a day; 4) a regular isotonic exercise program; and 5) cessation of tobacco consumption.", "output": {"entities": {}}, "schema": []}
{"input": "Ga-67 and Tl-201 scintigraphy in extramedullary plasmacytoma: a case report.", "output": {"entities": {}}, "schema": []}
{"input": "Arterial blood gas tensions were similar across all ventilation modes.", "output": {"entities": {}}, "schema": []}
{"input": "As expected, homologous loxP sequences efficiently underwent Cre-mediated recombination.", "output": {"entities": {"gene": [{"text": "homologous loxP sequences", "start": 13, "end": 38}, {"text": "Cre", "start": 61, "end": 64}]}}, "schema": []}
{"input": "The Van der Hoeve' s syndrome lesions as poorly mineralized, with low calcium salt and apparent increase of phosphates.", "output": {"entities": {}}, "schema": []}
{"input": "A 5-month-old infant with persistent congenital stridor and acute respiratory distress is presented.", "output": {"entities": {}}, "schema": []}
{"input": "PURPOSE: The objective of this study was to assess first embryo cleavage (FEC) 25-27 h after intracytoplasmic sperm injection (ICSI) as a parameter for the embryo selection process.", "output": {"entities": {}}, "schema": []}
{"input": "In 35 of those patients DD was measured also with microlatex tests--Tinaquant and BC d-dimer.", "output": {"entities": {}}, "schema": []}
{"input": "Cytosolic acetyl-CoA synthetase (AceCS1) activates acetate to supply the cells with acetyl-CoA for lipid synthesis.", "output": {"entities": {"gene": [{"text": "Cytosolic acetyl-CoA synthetase", "start": 0, "end": 31}, {"text": "AceCS1", "start": 33, "end": 39}]}}, "schema": []}
{"input": "Tolerance in renal transplantation after allogeneic bone marrow transplantation-6-year follow-up.", "output": {"entities": {}}, "schema": []}
{"input": "Foreigners return.", "output": {"entities": {}}, "schema": []}
{"input": "The present chemotherapy of AE is based on the administration of benzimidazole carbamate derivatives, such as mebendazole and albendazole.", "output": {"entities": {}}, "schema": []}
{"input": "Topological and mutational analysis of Saccharomyces cerevisiae Ste14p, founding member of the isoprenylcysteine carboxyl methyltransferase family.", "output": {"entities": {"gene": [{"text": "Saccharomyces cerevisiae Ste14p", "start": 39, "end": 70}, {"text": "isoprenylcysteine carboxyl methyltransferase family", "start": 95, "end": 146}]}}, "schema": []}
{"input": "Hormonal regulation of multiple promoters of the rat mitochondrial glycerol-3-phosphate dehydrogenase gene: identification of a complex hormone-response element in the ubiquitous promoter B.", "output": {"entities": {"gene": [{"text": "rat mitochondrial glycerol-3-phosphate dehydrogenase gene", "start": 49, "end": 106}]}}, "schema": []}
{"input": "The telomerase RNA-protein complex responsible for maintenance of telomeric DNA at chromosome ends, is usually inactive in most primary somatic human cells, but is specifically activated with in vitro immortalization and during tumorigenesis.", "output": {"entities": {"gene": [{"text": "telomerase RNA-protein complex", "start": 4, "end": 34}]}}, "schema": []}
{"input": "Our results show that CVN specifically recognizes with nanomolar affinity Man (9) GlcNAc (2) and the D1D3 isomer of Man (8) GlcNAc (2).", "output": {"entities": {"gene": [{"text": "CVN", "start": 22, "end": 25}]}}, "schema": []}
{"input": "Zhu, V.", "output": {"entities": {}}, "schema": []}
{"input": "The novel approach to insulin administration known as chronic intermittent intravenous insulin therapy (CIIIT) delivers insulin in a pulsatile fashion and achieves physiological insulin concentration in the portal vein.", "output": {"entities": {"gene": [{"text": "insulin", "start": 22, "end": 29}, {"text": "insulin", "start": 87, "end": 94}, {"text": "insulin", "start": 120, "end": 127}, {"text": "insulin", "start": 178, "end": 185}]}}, "schema": []}
{"input": "The activity of Rac1 leads to STAT3 translocation to the nucleus coincident with STAT3-dependent gene expression.", "output": {"entities": {"gene": [{"text": "Rac1", "start": 16, "end": 20}, {"text": "STAT3", "start": 30, "end": 35}, {"text": "STAT3", "start": 81, "end": 86}]}}, "schema": []}
{"input": "Mss4 also acts as a relatively inefficient guanine nucleotide exchange factor (GEF).", "output": {"entities": {"gene": [{"text": "Mss4", "start": 0, "end": 4}, {"text": "guanine nucleotide exchange factor", "start": 43, "end": 77}, {"text": "GEF", "start": 79, "end": 82}]}}, "schema": []}
{"input": "She has since developed a positive anti-cardiolipin antibody but does not meet diagnostic criteria for systemic lupus erythematosis. CONCLUSION: The presence of known autoimmune disease in a woman with POF should not dissuade the clinician from evaluating for a potential genetic cause.", "output": {"entities": {"gene": [{"text": "anti-cardiolipin antibody", "start": 35, "end": 60}]}}, "schema": []}
{"input": "Effects of aerosol-vapor JP-8 jet fuel on the functional observational battery, and learning and memory in the rat.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSION: There are no differences in the measurement data derived from this method and actual measurement data from an object created by the computer-aided dental design program.", "output": {"entities": {}}, "schema": []}
{"input": "Many factors do influence the educational outcome in students and large statistical power (such as meta analysis) should be helpful to eliminate many sources of error.", "output": {"entities": {}}, "schema": []}
{"input": "Our results demonstrated that 50% of the hepatic artery-alone ALT graft showed almost normal structure histologically at 1 month after grafting, with bile secretion preserved.", "output": {"entities": {}}, "schema": []}
{"input": "The human ABCG1 gene encodes a member of the ATP-binding cassette (ABC) superfamily of transporter proteins and is highly induced when macrophages are incubated with oxysterols.", "output": {"entities": {"gene": [{"text": "human ABCG1 gene", "start": 4, "end": 20}, {"text": "ATP-binding cassette", "start": 45, "end": 65}, {"text": "ABC", "start": 67, "end": 70}, {"text": "transporter proteins", "start": 87, "end": 107}]}}, "schema": []}
{"input": "C/EBPbeta LIP overexpressing HC11 cells did not express beta-casein mRNA (mammary epithelial cell differentiation marker) in response to lactogenic hormones.", "output": {"entities": {"gene": [{"text": "C/EBPbeta LIP", "start": 0, "end": 13}, {"text": "beta-casein mRNA", "start": 56, "end": 72}]}}, "schema": []}
{"input": "EXAFS measurements around the Ge-K edge have been carried out for liquid Ge-Si alloys for the first time to investigate the local structure around a Ge atom.", "output": {"entities": {}}, "schema": []}
{"input": "Although metabolized by the cytochrome P-450 (CYP) system, venlafaxine inhibits CYP 2D6 and 3A4 to a far lesser extent than do the SSRIs.", "output": {"entities": {"gene": [{"text": "cytochrome P-450", "start": 28, "end": 44}, {"text": "CYP", "start": 46, "end": 49}, {"text": "CYP 2D6 and 3A4", "start": 80, "end": 95}]}}, "schema": []}
{"input": "Analysis of the promoter sequence revealed the presence of a major transcriptional start site, a canonical TATA box and putative cis regulatory elements for pituitary specific expression as well as an E-responsive element.", "output": {"entities": {}}, "schema": []}
{"input": "Novel intronic promoter in the rat ER alpha gene responsible for the transient transcription of a variant receptor.", "output": {"entities": {"gene": [{"text": "rat ER alpha gene", "start": 31, "end": 48}]}}, "schema": []}
{"input": "Pitx2 rescues the GABAergic differentiation defect and partially rescues the axon guidance and behavioral phenotypes of unc-30 mutants, indicating a high degree of functional conservation between these evolutionarily related genes.", "output": {"entities": {"gene": [{"text": "Pitx2", "start": 0, "end": 5}, {"text": "unc-30 mutants", "start": 120, "end": 134}]}}, "schema": []}
{"input": "We have previously shown that the adenoviral 12S E1A protein modulates the phosphorylation status of p130 and p107 without apparent changes in the cell cycle dependent phosphorylation of the retinoblastoma protein.", "output": {"entities": {"gene": [{"text": "adenoviral 12S E1A protein", "start": 34, "end": 60}, {"text": "p130", "start": 101, "end": 105}, {"text": "p107", "start": 110, "end": 114}, {"text": "retinoblastoma protein", "start": 191, "end": 213}]}}, "schema": []}
{"input": "The prevalence of tobacco dependence diagnosed according to the ICD-10 criteria was higher in alcohol-dependent individuals (58. 1%) than in nondrinkers or social drinkers (12. 8%).", "output": {"entities": {}}, "schema": []}
{"input": "Diffuse myalgias were more frequent in patients with than without an MMF lesion at deltoid muscle biopsy (P < 0. 0001).", "output": {"entities": {}}, "schema": []}
{"input": "Additionally, a CaCO3-CO2/N2 buffered solution was necessary to maintain a pH of 8.", "output": {"entities": {}}, "schema": []}
{"input": "Copyright 2001 S.", "output": {"entities": {}}, "schema": []}
{"input": "NF-kappaB is involved in the regulation of CD154 (CD40 ligand) expression in primary human T cells.", "output": {"entities": {"gene": [{"text": "NF-kappaB", "start": 0, "end": 9}, {"text": "CD154", "start": 43, "end": 48}, {"text": "CD40 ligand", "start": 50, "end": 61}]}}, "schema": []}
{"input": "Mutation of the octamer element also significantly reduced the ability of HDAC1 to confer repression of inducible HLA-DRA promoter activation.", "output": {"entities": {"gene": [{"text": "HDAC1", "start": 74, "end": 79}, {"text": "HLA-DRA promoter", "start": 114, "end": 130}]}}, "schema": []}
{"input": "In such conditions, the following kinetic reactions have been studied: N2 (A) + N2 (A)--> N2 (C, B, V') + N2 (X), N2 (A) + N2 (X, V > 5)--> N2 (X) + N2 (B, V') in pure N2 post-discharges and N2 (A) + CH4--> products, C + N + M2--> CN (B, V') + M2, N2 (X, V > 4) + CN--> N2 (X) + CN (B, A, V'), in N2-1% CH4 post-discharges.", "output": {"entities": {}}, "schema": []}
{"input": "Six of the gstC' mutants, primarily in the C-terminal half of C', exhibited a defect in the ability to bind L protein.", "output": {"entities": {"gene": [{"text": "gstC' mutants", "start": 11, "end": 24}, {"text": "C'", "start": 62, "end": 64}, {"text": "L protein", "start": 108, "end": 117}]}}, "schema": []}
{"input": "A proposal of 50 performance indicators divided into five different groups is presented here, namely structural indicators, operational indicators, water and service quality indicators, personnel indicators and economic indicators.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSIONS: ChromaFlo-enhanced IVUS demonstrates colorized blood flow inside the vessel lumen, which is helpful in distinguishing echolucent disease from luminal blood flow and can also be used to perform peripheral interventions in patients with renal failure or allergy, avoiding the use of contrast media.", "output": {"entities": {}}, "schema": []}
{"input": "The hatcher incubators of both companies were also persistently contaminated with Salmonella livingstone and Salmonella thomasville in company A and with Salmonella senftenberg in company B.", "output": {"entities": {}}, "schema": []}
{"input": "At both companies sites Salmonella enteritidis and Salmonella typhimurium Tr104 were also isolated occasionally from various locations.", "output": {"entities": {}}, "schema": []}
{"input": "E2F1-mediated transcriptional inhibition of the plasminogen activator inhibitor type 1 gene.", "output": {"entities": {"gene": [{"text": "E2F1", "start": 0, "end": 4}, {"text": "plasminogen activator inhibitor type 1 gene", "start": 48, "end": 91}]}}, "schema": []}
{"input": "The small copepod Pseudonychocamptus proximus progressively replaced the large Tisbe furcata in sand filters during the fall of 1995 and was responsible for the large increase in meiofaunal biomass observed after spring 1996.", "output": {"entities": {}}, "schema": []}
{"input": "The probability of treatment with lamotrigine being maintained for six months was 86%, for twelve months 61% and for three years 31%.", "output": {"entities": {}}, "schema": []}
{"input": "Data from in vitro splicing assays, UV crosslinking and RNA-binding competition experiments indicates a strong correlation between the binding affinities of PSI for the SELEX sequences and their ability to modulate splicing of P element IVS3 in vitro.", "output": {"entities": {"gene": [{"text": "PSI", "start": 157, "end": 160}, {"text": "P element IVS3", "start": 227, "end": 241}]}}, "schema": []}
{"input": "This paper describes the results of an initial study on the application of linear solvation energy relationships (LSERs) to the prediction of internal standard compounds in reversed-phase liquid chromatographic (RPLC) method development.", "output": {"entities": {}}, "schema": []}
{"input": "ICAM-1 has been suggested a predictor of the onset of GO.", "output": {"entities": {"gene": [{"text": "ICAM-1", "start": 0, "end": 6}]}}, "schema": []}
{"input": "Northern blot analysis with one of the PARNAs revealed a highly abundant signal of approximately 2. 0 kilobases (kb) present in all cell lines tested.", "output": {"entities": {"gene": [{"text": "PARNAs", "start": 39, "end": 45}]}}, "schema": []}
{"input": "The corresponding orifice voltages for the three instruments were 20/50/80 V (API 365), 30/90/130 V (API 2000) and 40/80/120 V (API 3000).", "output": {"entities": {}}, "schema": []}
{"input": "The LA 50s derived from this combined data when compared with our earlier series from 1965 to 1970 also did not show a significant change in mortality.", "output": {"entities": {}}, "schema": []}
{"input": "Treatment of ischemic heart disease in the elderly", "output": {"entities": {}}, "schema": []}
{"input": "A peculiar people: \" the physiological aspects of Mormonism 1850-1975. \"", "output": {"entities": {}}, "schema": []}
{"input": "She drank alcohol once or twice a week and regularly took an analgesic preparation, containing aspirin and acetaminophen, for alleviation of headaches.", "output": {"entities": {}}, "schema": []}
{"input": "The most important risk factors are: 1) genetic; 2) Epstein-Barr virus (infectious mononucleosis); 3) congenital and acquired immunodeficiency; 4) occupational exposure (the wood industry).", "output": {"entities": {}}, "schema": []}
{"input": "OBJECTIVES: The objective of this review was to assess the effects of prophylactic prostaglandin use in the third stage of labour.", "output": {"entities": {}}, "schema": []}
{"input": "Under our conditions, the combination O3/UV did not improve the degradation rate obtained by ozonation.", "output": {"entities": {}}, "schema": []}
{"input": "On the other hand, hepatic arterial infusion therapy prolongs the survival of H3 patients only.", "output": {"entities": {}}, "schema": []}
{"input": "Finally, there are a growing number of arguments favouring the use of ACE inhibitors very early in patients with diabetes mellitus.", "output": {"entities": {"gene": [{"text": "ACE", "start": 70, "end": 73}]}}, "schema": []}
{"input": "Is clopidogrel superior to aspirin in secondary prevention of vascular disease? The cornerstone in clinical evidence of the relative efficacy of thienopyridines (clopidogrel, ticlopidine) versus aspirin in the secondary prevention of vascular disease is the Clopidogrel versus Aspirin in Patients at Risk of Ischaemic Events trial.", "output": {"entities": {}}, "schema": []}
{"input": "We hypothesize that proprioception may be used to calibrate the efference copy during development and in response to perturbations by signaling potential mismatches between eye movement information derived from the efferent command and the actual motion of the eye transduced by the proprioceptive organs.", "output": {"entities": {}}, "schema": []}
{"input": "The severity of clinical course was expressed by means of SOFA score (group A 0. 3-1-1. 3 point, group B 2. 2-2. 9-2. 6 point, group C 7. 4-8. 3-7. 7 point) and APACHE II score (group A 3. 7-7. 6-8. 1 point, group B 8. 6-11. 1-10. 5 point, group C 16. 3-15. 2-14. 3 point).", "output": {"entities": {}}, "schema": []}
{"input": "These results were compared with the estimates of penetration from steady-state calculations, square root of time calculations, and a biologically based mathematical model.", "output": {"entities": {}}, "schema": []}
{"input": "Treadmill training at least for 2 weeks can reduce the infarction size and edema caused by MCA occlusion (P < 0. 01).", "output": {"entities": {}}, "schema": []}
{"input": "Modality-specific areas (e. g., right Wernicke, left fusiform gyrus, Broca BA44, supramarginal gyrus), appear to cope with the computations relevant to making contact with these more abstract dimensions.", "output": {"entities": {}}, "schema": []}
{"input": "We found no correlation between plasma COP and body weight at the same age (r2 = 0. 05, P = 0. 155).", "output": {"entities": {}}, "schema": []}
{"input": "Both toxins in a dose 10-fold surpassing the maximum permissible concentration increased activity of glutathione peroxidase in brain tissue; moreover, toluene increased chemiluminescence intensity, which attested to activation of free radical processes.", "output": {"entities": {"gene": [{"text": "glutathione peroxidase", "start": 101, "end": 123}]}}, "schema": []}
{"input": "The performance of pH-sensitive particles is attributed to their ability to release the drug selectively in the upper part of the intestine in a molecular or amorphous form.", "output": {"entities": {}}, "schema": []}
{"input": "Comparison of remnant-like lipoprotein particles in postmenopausal women with and without coronary artery disease and in men with coronary artery disease.", "output": {"entities": {}}, "schema": []}
{"input": "Because results of recent randomized trials indicate minimal efficacy of continuing MAC prophylaxis in patients who respond to potent combination antiretroviral therapy, the observed high incidence of macrolide-resistant bacterial colonization of the respiratory tract in this trial supports the discontinuation of macrolide prophylaxis in all AIDS patients whose CD4 counts have risen above 100 cells/microL.", "output": {"entities": {"gene": [{"text": "CD4", "start": 364, "end": 367}]}}, "schema": []}
{"input": "METHODS: 302 consecutive patients with BS and 438 patients with other rheumatological conditions were surveyed for the presence or absence of the features of BS by means of a standard form which had been prepared according to ISG criteria.", "output": {"entities": {}}, "schema": []}
{"input": "A computer program, ACCESS-IAQ, is developed to simulate the airflow pattern, the time history of the contaminant concentrations in the occupied zone, and the inhalation exposures.", "output": {"entities": {}}, "schema": []}
{"input": "Classification according to the ILAR criteria was possible in 321 patients; 290 patients had a disease duration > or = 3 months and were classified according to the EULAR criteria.", "output": {"entities": {}}, "schema": []}
{"input": "We conducted a clinical and pathologic review of nine patients with immature ovarian teratoma.", "output": {"entities": {}}, "schema": []}
{"input": "The results are discussed in relation to acoustical models of sound propagation and physiology, and it is suggested that height-dependent degradation within a forest is an important selection pressure for transmissibility in avian communication.", "output": {"entities": {}}, "schema": []}
{"input": "In sterilized milk there was a slight decrease of linoleic acid (C18: 2n6;-0. 7% vs. fresh; P = 0. 006) and arachidonic acid (C20: 4n6;-2. 5%; P = 0. 045).", "output": {"entities": {}}, "schema": []}
{"input": "The electrodes themselves do not need to be polished prior to their use but are observed to be slightly recessed from the surrounding insulating surface.", "output": {"entities": {}}, "schema": []}
{"input": "Because the DPPD gene is not present in non-tuberculous bacilli, these results suggest that this molecule can be an additional tool for a more specific diagnosis of tuberculosis.", "output": {"entities": {"gene": [{"text": "DPPD gene", "start": 12, "end": 21}]}}, "schema": []}
{"input": "Patients with a secondary cardiac event had more common Type A behavior patterns and higher Bortner scores than patients without a secondary cardiac event.", "output": {"entities": {}}, "schema": []}
{"input": "Interestingly, continuation of the interferon therapy in the presence of a mild-to-moderate exacerbation of sarcoidosis may be safe in a minority of patients with noncritical organ involvement.", "output": {"entities": {"gene": [{"text": "interferon", "start": 35, "end": 45}]}}, "schema": []}
{"input": "There was no difference in apnea duration between the supine and prone positions.", "output": {"entities": {}}, "schema": []}
{"input": "TNFalpha and IL-6 levels were determined in the culture supernatants.", "output": {"entities": {"gene": [{"text": "TNFalpha", "start": 0, "end": 8}, {"text": "IL-6", "start": 13, "end": 17}]}}, "schema": []}
{"input": "Therefore, this study has demonstrated that prenatal disturbance can induce a lasting change in cytokine biology, which persists well beyond the fetal and infant stage.", "output": {"entities": {}}, "schema": []}
{"input": "Based on analytic precisions, a +/-2% urine-plasma difference was set as the cut-off value.", "output": {"entities": {}}, "schema": []}
{"input": "Schistosoma mansoni schistosomiasis] Schistosomosis are parasitic diseases caused by blood flukes of the Schistosoma genus.", "output": {"entities": {}}, "schema": []}
{"input": "Emphysematous cholecystitis: sonographic findings.", "output": {"entities": {}}, "schema": []}
{"input": "Age was categorized into four groups: 20-44, 45-64, 65-74, and 75 +. RESULTS: At the initiation of dialysis PD patients were approximately 6 years younger (P < 0. 0001) than HD patients.", "output": {"entities": {}}, "schema": []}
{"input": "The utility of such analyses in the design of ceramic/substrate bilayer systems for optimal resistance to lifetime-threatening damage is discussed.", "output": {"entities": {}}, "schema": []}
{"input": "Adjacent to those lesions, and in homologous contralateral structures, FMZ binding was analysed in four pairs of cortical 9 x 9-mm regions of interest (ROIs) placed on transaxial and coronal slices, respectively, as well as in the lesion volume and its mirror region.", "output": {"entities": {}}, "schema": []}
{"input": "Because a close correlation between regional decreases in FMZ binding and spiking activity was recently demonstrated in neocortical epilepsies, abnormal peri-lesional FMZ binding may bear some relation to the mechanisms of epileptogenesis in symptomatic epilepsies.", "output": {"entities": {}}, "schema": []}
{"input": "We found three out of four original (Volkan' s) groups of linking objects, but also an additional one, hitherto undescribed, comprising objects used for designing a memorial shrine to the deceased.", "output": {"entities": {}}, "schema": []}
{"input": "One CKD patient' s journey.", "output": {"entities": {}}, "schema": []}
{"input": "In patients who respond to quetiapine, therapy should be continued at the optimal dose that maintains remission, within the range of 150 to 750 mg/d.", "output": {"entities": {}}, "schema": []}
{"input": "With such analysis, one can test hypotheses about the structure of latent variability within a given data set.", "output": {"entities": {}}, "schema": []}
{"input": "In this study we wanted to assess the DR using the' combined test' in an unselected population of self-referred pregnant women at a false-positive rate (FPR) of about 5%.", "output": {"entities": {}}, "schema": []}