Input: Sagittal sinus thrombosis associated with transient free protein S deficiency after L-asparaginase treatment: case report and review of the literature.

Sagittal sinus thrombosis associated with transient free protein S deficiency

L-asparaginase treatment

after


Input: This case demonstrates the association of selective IgA deficiency with remission in rheumatoid arthritis induced by fenclofenac as well as aurothiomalate and sulphasalazine.

fenclofenac

aurothiomalate

sulphasalazine

remission in rheumatoid arthritis

This case

induced


Input: This study provides the first evidence that co-administration of prolonged-release oxycodone and existing gabapentin therapy has a clinically meaningful effect in painful diabetic neuropathy.

co-administration of prolonged-release oxycodone and existing gabapentin therapy

clinically meaningful effect

has


Input: In the present case report, the concomitant administration of clarithromycin and sirolimus determined impressive increase of sirolimus trough blood concentrations from 6.2 up to 54 ng/mL and this increase was associated with an acute impairment of renal function, almost completely reversed upon both drugs discontinuation.

the concomitant administration of clarithromycin and sirolimus

acute impairment of renal function

associated


Input: In one case, the readministration of riluzole was followed by the relapse of hepatitis.

riluzole

the relapse of hepatitis

readministration


Input: Pseudoephedrine-induced hemorrhage associated with a cerebral vascular malformation.

Pseudoephedrine

hemorrhage associated with a cerebral vascular malformation

induced


Input: PURPOSE: To report a case of severe corticosteroid-induced glaucoma after intravitreal injection of triamcinolone acetate in a 34-year-old man without a history of glaucoma.

intravitreal injection of triamcinolone acetate

glaucoma

a 34-year-old man without a history of glaucoma

severe

induced


Input: A transient tonic pupillary response, denervation supersensitivity, and abnormal visual-evoked potentials in quinine toxicity, to our knowledge, have not been previously reported.

transient tonic pupillary response, denervation supersensitivity, and abnormal visual-evoked potentials

quinine

not

reported


Input: Two days' administration of levomepromazine 100 mg led him to a coma for 2 days.

Two days' administration of levomepromazine 100 mg

a coma for 2 days

led


Input: Methimazole-induced aplastic anemia in third exposure: successful treatment with recombinant human granulocyte colony-stimulating factor.

Methimazole

aplastic anemia

induced


Input: BACKGROUND: We describe the ophthalmic features and clinical course of two cases of acute syphilitic posterior placoid chorioretinitis (ASPPC) that developed after intravitreal triamcinolone acetonide (IVTA) injection.

acute syphilitic posterior placoid chorioretinitis

intravitreal triamcinolone acetonide (IVTA) injection

developed


Input: Skin rash and splinter hemorrhages from ganciclovir.

ganciclovir

Skin rash and splinter hemorrhages

from


Input: We present a pediatric patient with leukemia and a severe, L-asparaginase-induced necrotizing pancreatitis, treated successfully with percutaneous drainage used to flush the infected necrotic parts.

pediatric patient with leukemia and a severe, L-asparaginase-induced necrotizing pancreatitis

percutaneous drainage

flush the infected necrotic parts.

used to

L-asparaginase

necrotizing pancreatitis

induced


Input: Such anagen effluvium with lichenoid eruption following INH therapy has not been observed previously.

INH

anagen effluvium with lichenoid eruption

following


Input: We conclude that MB is an effective treatment for ifosfamide-induced encephalopathy.

ifosfamide

encephalopathy

induced

MB

treatment


Input: Hyponatraemia during low-dose carbamazepine therapy.

Hyponatraemia

low-dose carbamazepine

during


Input: Acute coronary syndrome induced by capecitabine therapy.

Acute coronary syndrome

capecitabine therapy

induced


Input: A case of severe visual loss following a single dose of vincristine is described.

a single dose of vincristine

A case

severe visual loss

severe

following


Input: We report a case of a young woman with SLE and thrombocytopenia, who developed severe perspiration, headache, and seizure after receiving cyclosporine.

young woman with SLE and thrombocytopenia

severe perspiration, headache, and seizure

cyclosporine

after


Input: Although gabapentin withdrawal has been previously reported and usually consists of anxiety, diaphoresis, and palpitations, this is the first reported patient with generalized seizures and status epilepticus secondary to gabapentin withdrawal.

generalized seizures and status epilepticus

secondary to gabapentin withdrawal

patient

with


Input: Self-limited edema is a well-recognized complication of insulin therapy.

Self-limited edema

insulin

complication


Input: It is very likely that the dexamethasone used in the antiemetic drug regimen contributed to the development of osteonecrosis in these patients.

dexamethasone

osteonecrosis

these patients

likely

contributed


Input: A case is presented of a patient who experienced benzodiazepine withdrawal symptoms on discontinuation of nefazodone, an antidepressant that inhibits the cytochrome P450 3A4 isoenzyme.

a patient

benzodiazepine withdrawal symptoms

nefazodone

discontinuation


Input: Isotretinoin, a drug used for the treatment of acne, has been shown to have teratogenic effects.

teratogenic effects

Isotretinoin

shown

have


Input: The capacity of zuclopenthixol to induce priapism is thought to be due to its antagonist activity on alpha-adrenergic receptors.

zuclopenthixol

priapism

induce


Input: Two patients treated for chronic myeloid leukemia with high doses of CCNU (1100 mg/m2 and 1240 mg/m2, respectively) developed a fatal pulmonary fibrosis.

Two patients

chronic myeloid leukemia

CCNU (1100 mg/m2 and 1240 mg/m2, respectively)

pulmonary fibrosis

fatal

developed


Input: CONCLUSIONS: There is very little published information regarding ofloxacin-induced toxic epidermal necrolysis.

ofloxacin

toxic epidermal necrolysis

induced


Input: Our case is the second one in which hemorrhage from a meningioma may have been induced by aspirin prophylaxis.

hemorrhage from a meningioma

aspirin prophylaxis

Our case is the second one

may

induced


Input: Methemoglobinemia after axillary block with bupivacaine and additional injection of lidocaine in the operative field.

Methemoglobinemia

axillary block with bupivacaine and additional injection of lidocaine in the operative field

after


Input: Nonconvulsive status epilepticus: the role of morphine and its antagonist.

Nonconvulsive status epilepticus

morphine and its antagonist

the role


Input: Acute myeloid leukemia evolving from essential thrombocythemia in two patients treated with hydroxyurea.

two patients

hydroxyurea

Acute myeloid leukemia

treated


Input: Central nervous system manifestations of an ibuprofen overdose reversed by naloxone.

naloxone

by


Input: BACKGROUND: Aphthous stomatitis, a common mucocutaneous disorder, is a well accepted complication of sirolimus therapy.

Aphthous stomatitis

sirolimus

complication


Input: The goal of this article was to describe a potential drug-drug interaction between propafenone and citalopram, which caused symptoms of propafenone adverse effects.

symptoms of propafenone adverse effects

drug-drug interaction between propafenone and citalopram

potential

caused


Input: Temporary neurologic abnormalities were observed in one out of 23 patients undergoing chemotherapy with high-dose methotrexate (HD-MTX) for osteogenic sarcoma.

Temporary neurologic abnormalities

one out of 23 patients

chemotherapy with high-dose methotrexate (HD-MTX)

Temporary

observed


Input: This is the first report of a possible interaction between propafenone and citalopram, which caused propafenone adverse effects (eg, dizziness, falls) and mimicked coronary artery disease.

propafenone adverse effects (eg, dizziness, falls) and mimicked coronary artery disease

propafenone and citalopram

propafenone

possible

caused


Input: Spontaneous bacterial peritonitis induced by intraarterial vasopressin therapy.

intraarterial vasopressin therapy

Spontaneous bacterial peritonitis

induced


Input: Ciclesonide reduces the need for oral steroid use in adult patients with severe, persistent asthma.

Ciclesonide

adult patients

reduces


Input: Five cases (four from the literature and one new case) are presented in which patients unsuspected of having vitamin B12 deficiency developed subacute combined degeneration of the spinal cord following nitrous oxide anesthesia.

subacute combined degeneration of the spinal cord

Five cases (four from the literature and one new case) are presented in which patients unsuspected of having vitamin B12 deficiency

nitrous oxide anesthesia

developed


Input: CASE SUMMARY: We report the case of a 31-year-old patient hospitalized due to behavioral alterations and treated with oral zuclopenthixol, an antipsychotic from the thioxanthene family, who developed an acute, painful erection.

a 31-year-old patient

oral zuclopenthixol

acute, painful erection

developed


Input: Three cases of acute renal toxicity in patients receiving long-term therapy with mitomycin C and 5-fluorouracil are reported.

acute renal toxicity

patients

mitomycin C and 5-fluorouracil

long-term

reported


Input: A 40-year-old man with a long standing history of rheumatoid arthritis was treated with MTX over a 6 month period and developed an overwhelming hepatic necrosis.

A 40-year-old man with a long standing history of rheumatoid arthritis

MTX over a 6 month period

an overwhelming hepatic necrosis

overwhelming

developed


Input: In case 1, a total daily dose of 25 mg sertraline, with nondetectable sertraline and desmethylsertraline blood levels, resulted in a doubling of the lamotrigine blood level with symptoms of toxicity.

a total daily dose of 25 mg sertraline

In case 1

doubling of the lamotrigine blood level with symptoms of toxicity

resulted


Input: Since the bronchospasm was relieved with discontinuation of propranolol and supportive bronchodilator therapy, the bronchospasm was believed to be caused by propranolol.

bronchospasm

propranolol

caused


Input: A depressed woman with no history of bipolar illness developed a manic episode during treatment with fluoxetine.

A depressed woman with no history of bipolar illness

manic episode

fluoxetine

during


Input: Priapism associated with trazodone therapy: case report.

Priapism

trazodone therapy

associated


Input: OBJECTIVE: To report the occurrence of anterior ischemic optic neuropathy as a complication of treatment with interferon alfa and to consider the possible underlying mechanisms for this association.

anterior ischemic optic neuropathy

interferon alfa

possible underlying mechanisms

complication


Input: Mequitazine seemed to play a part similar to chlorpromazine, and absence of mequitazine-induced photosensitivity may be due to a relatively low dosage of the drug.

mequitazine

due to a relatively low dosage of the drug

photosensitivity

may

induced


Input: Although various manifestations of pentamidine-induced cardiotoxicity have been reported, to our knowledge, second-degree heart block associated with this agent has not been described.

pentamidine

cardiotoxicity

induced

pentamidine

second-degree heart block

not been described

associated


Input: The mean weekly warfarin dose while the patient was receiving emtricitabine monotherapy was 13.3 mg (95% CI 12.7 to 13.8), with a mean international normalized ratio (INR) of 2.8 (95% CI 2.5 to 3.1).

The mean weekly warfarin dose

emtricitabine monotherapy was 13.3 mg (95% CI 12.7 to 13.8)

the patient

receiving


Input: We report a case of penile fibrosis after intracavernous self-injection of a combination of phentolamine and papaverine.

penile fibrosis

intracavernous self-injection of a combination of phentolamine and papaverine

after


Input: This is, to the best of our knowledge, the first report of a case in which agranulocytosis followed treatment with both propylthiouracil and methimazole in the same patient.

agranulocytosis

both propylthiouracil and methimazole

the same patient

followed


Input: Itch and skin rash from chocolate during fluoxetine and sertraline treatment: case report.

Itch and skin rash

chocolate during fluoxetine and sertraline treatment

from


Input: Oxycodone-gabapentin co-administration was associated with less escape medication use (P = 0.03) and fewer nights of disturbed sleep (P < 0.05).

Oxycodone-gabapentin co-administration

less escape medication use (P = 0.03) and fewer nights of disturbed sleep (P < 0.05)

associated


Input: Gynecomastia in epileptics treated with phenobarbital, phenytoin and fluoresone: two case reports.

Gynecomastia

phenobarbital, phenytoin and fluoresone

with


Input: Captopril-induced lichen planus pemphigoides with pemphigus-like features.

Captopril

lichen planus pemphigoides

induced


Input: The literature on thiabendazole-induced cholestasis and its association with sicca complex is reviewed.

thiabendazole

cholestasis

induced


Input: How low can you go? Use of very low dosage of gold in patients with mucocutaneous reactions.

very low dosage of gold

patients with mucocutaneous reactions

Use


Input: A 55-year-old HIV-positive African woman received a single epidural triamcinolone injection for pain relief of postherpetic neuralgia.

A 55-year-old HIV-positive African woman

a single epidural triamcinolone injection

received


Input: Anaphylactoid shock, disseminated intravascular coagulation, and anuric renal failure requiring dialysis occurred in a patient receiving zomepirac sodium for toothache.

a patient

toothache

zomepirac sodium

Anaphylactoid shock, disseminated intravascular coagulation, and anuric renal failure requiring dialysis

occurred


Input: During dose-finding studies for intravenous proton pump inhibitors omeprazole and pantoprazole, three of six young female volunteers receiving omeprazole and two young female volunteers receiving pantoprazole developed peripheral edema within 8 hr when high doses of the proton pump inhibitors were applied by continuous infusion together with large volumes of fluid.

three of six young female volunteers

omeprazole

high doses of the proton pump inhibitors were applied by continuous infusion together with large volumes of fluid

peripheral edema within 8 hr

developed

peripheral edema within 8 hr

pantoprazole

high doses of the proton pump inhibitors were applied by continuous infusion together with large volumes of fluid

two young female volunteers

developed


Input: Intravenous levodopa 25 mg ameliorated his akathisia symptoms drastically.

Intravenous levodopa 25 mg

ameliorated


Input: Cyclosporine-induced pain syndrome in a child undergoing hematopoietic stem cell transplant.

Cyclosporine

pain syndrome

a child undergoing hematopoietic stem cell transplant

induced


Input: Visual loss after a single small dose of vincristine has never been reported.

Visual loss

a single small dose of vincristine

never

after


Input: Slow acetylator genotypes as a possible risk factor for infectious mononucleosis-like syndrome induced by salazosulfapyridine.

infectious mononucleosis-like syndrome

salazosulfapyridine

possible

induced by


Input: Clinicians should be aware of raltegravir-induced DRESS syndrome as well as the potential for drug-drug interactions due to protease inhibitor-based therapy.

raltegravir

DRESS syndrome

potential

induced


Input: CONCLUSION: Under certain circumstances topical brimonidine can cause paradoxical raised IOP necessitating vigilance in follow-up of patients on topical brimonidine.

patients on topical brimonidine

raised IOP

topical brimonidine

certain

cause


Input: Pharmacokinetic modeling suggested that the patient's initial over-treatment was as reported and that the predicted maximum serum concentration of chloroquine (902 micro g/L) was within the range seen in fatal chloroquine overdose.

the patient's

chloroquine (902 micro g/L)

fatal

over-treatment


Input: There was no apparent cardiovascular interaction between clopidogrel and omeprazole, but our results do not rule out a clinically meaningful difference in cardiovascular events due to use of a PPI.

PPI

cardiovascular

no

do not rule out

due


Input: Anaphylactic/anaphylactoid reactions to methotrexate are rare.

Anaphylactic/anaphylactoid reactions

methotrexate

to


Input: Continuous bladder irrigation of a 1% alum solution is a simple and generally safe method of chemical cautery to treat the bleeding urothelium.

Continuous bladder irrigation of a 1% alum solution

treat


Input: The temporal relationship suggests that the spinal cord infarction may be related to the use of zolmitriptan.

zolmitriptan

spinal cord infarction

may

related


Input: Delusional parasitosis associated with phenelzine.

Delusional parasitosis

phenelzine

associated


Input: CONCLUSION: The administration of tissue plasminogen activator was responsible for the large extent of hemorrhage and should be considered in the differential diagnosis of hemorrhagic choroidal detachment.

tissue plasminogen activator

large extent of hemorrhage

should be considered

responsible


Input: Dihydropyrimidine dehydrogenase deficiency: a pharmacogenetic defect causing severe adverse reactions to 5-fluorouracil-based chemotherapy.

severe adverse reactions

5-fluorouracil-based chemotherapy

severe

to


Input: Interferon-beta (IFN-beta) is a type I interferon used in the management of multiple sclerosis.

Interferon-beta (IFN-beta) is a type I interferon

used in


Input: Quetiapine-induced leucopenia and thrombocytopenia.

Quetiapine

leucopenia and thrombocytopenia.

induced


Input: CONCLUSION: Severe and sustained ocular hypertension may occur after intravitreal ranibizumab.

intravitreal ranibizumab

Severe and sustained ocular hypertension

may

Severe and sustained

after


Input: BACKGROUND: To describe the occurrence of ocular hypertension in four patients following injection of ranibizumab intravitreally.

ocular hypertension

four patients

ranibizumab

occurrence


Input: Vancomycin is widely used against methicillin-resistant Staphylococcus aureus infections, but it is associated with many adverse effects such as nephrotoxicity, ototoxicity, gastrointestinal disturbances, blood disorders, and two types of hypersensitivity reactions - an anaphylactoid reaction known as "red man syndrome" and anaphylaxis.

Vancomycin

nephrotoxicity, ototoxicity, gastrointestinal disturbances, blood disorders, and two types of hypersensitivity reactions - an anaphylactoid reaction known as "red man syndrome" and anaphylaxis

associated


Input: We report a case of unintentional overdose of oral pilocarpine tablets that resulted in bradycardia, mild hypotension, and muscarinic symptoms in a patient with Sjogren's syndrome.

pilocarpine

bradycardia, mild hypotension, and muscarinic symptoms

resulted


Input: Moreover, treatment with immunosuppressive drugs such as cyclosporine, cisplatin, tacrolimus, and interferon-alpha can induce a condition resembling RPLS.

RPLS

immunosuppressive drugs such as cyclosporine, cisplatin, tacrolimus, and interferon-alpha

can

induce


Input: Case 1, a 62-year-old woman, developed bilateral optic neuritis with decreased sensation of vibration and increased deep tendon reflex in the lower extremities after a seven-month use of recombinant interferon alpha-2a for chronic active hepatitis C.

a seven-month use of recombinant interferon alpha-2a for chronic active hepatitis C.

a 62-year-old woman

bilateral optic neuritis with decreased sensation of vibration and increased deep tendon reflex in the lower extremities

after


Input: A syndrome of increased affect in response to risperidone among patients with schizophrenia.

patients with schizophrenia

A syndrome of increased affect

risperidone

response


Input: Therapy with IFN-beta has rarely been associated with the development of autoimmune disorders.

IFN-beta

autoimmune disorders

rarely been associated

development


Input: Despite these antithrombotic effects, the patient developed repeated venous thromboembolism during treatment with low-molecular-weight heparin.

repeated venous thromboembolism

treatment with low-molecular-weight heparin

during


Input: Hyponatraemia developed after rechallenge with controlled release carbamazepine.

Hyponatraemia

rechallenge with controlled release carbamazepine

developed


Input: Azathioprine-induced warfarin resistance.

Azathioprine

warfarin resistance.

induced


Input: Reversible valproic acid-induced dementia: a case report.

dementia

valproic acid

induced


Input: Parenteral-verapamil-induced sustained hypotension.

Parenteral-verapamil

sustained hypotension

induced


Input: The main side-effects of Lp-TAE combined with HT were low-grade fever, localized pain, myelo-suppression and liver dysfunction, but these were transient and eventually disappeared.

Lp-TAE combined with HT

low-grade fever, localized pain, myelo-suppression and liver dysfunction

side-effects


Input: Unique behavioral change with cinepazide in parkinsonism.

cinepazide

Unique behavioral change

with


Input: The literature of vincristine optic nerve toxicity is reviewed.

vincristine

optic nerve toxicity

toxicity


Input: PATIENTS: Two patients, ages 40 and 51 years, undergoing treatment with interferon alfa for malignant neoplasms experienced sudden bilateral, sequential visual loss with disc-related field defects and segmental optic disc edema.

Two patients, ages 40 and 51 years

interferon alfa

bilateral, sequential visual loss with disc-related field defects and segmental optic disc edema

experienced


Input: Neurological improvement and rehabilitation potential following toxic myelopathy due to intrathecal injection of doxorubicin.

toxic myelopathy

intrathecal injection of doxorubicin

due to


Input: Generalised cutaneous rash associated with ganciclovir therapy has rarely been reported in literature.

Generalised cutaneous rash

ganciclovir therapy

associated with


Input: Anaphylaxis after the injection of chymopapain occurs in about 1% of such cases.

Anaphylaxis

the injection of chymopapain

cases

occurs


Input: Heat stroke-like episode in a child caused by zonisamide.

Heat stroke-like episode

zonisamide

a child

caused


Input: An interaction between methylene blue and serotonergic agents may give rise to the serotonin syndrome.

methylene blue and serotonergic agents

serotonin syndrome

may

rise


Input: These cases suggest the possibility that, in some patients, leukopenia or agranulocytosis during olanzapine treatment might be dose-related.

in some patients

olanzapine treatment

leukopenia or agranulocytosis

possibility

during


Input: Adult respiratory distress syndrome after treatment with pegylated interferon alpha-2a and ribavirin.

Adult respiratory distress syndrome

pegylated interferon alpha-2a and ribavirin

with


Input: CONCLUSIONS: The increasing prevalence of Type 2 diabetes and its treatment with metformin might result in more cases of lactic acidosis.

metformin

lactic acidosis

result


Input: Sustained ventricular tachycardia in a thalidomide-treated patient with primary plasma-cell leukemia.

thalidomide

Sustained ventricular tachycardia

patient with primary plasma-cell leukemia

treated


Input: The second is a 29-year-old man with CD in whom nodular sclerosing Hodgkin's lymphoma was diagnosed 3 weeks after infusion with infliximab.

a 29-year-old man with CD

nodular sclerosing Hodgkin's lymphoma

3 weeks after infusion with infliximab

diagnosed


Input: We suggest discontinuing gemcitabine if radiation recall is observed.

discontinuing gemcitabine

radiation recall

if


Input: OBJECTIVE: To report the occurrence of acute cytolytic hepatitis in a patient exposed to pulse itraconazole therapy for 24 weeks and provide a concise review of the literature on cases of itraconazole-induced hepatitis.

acute cytolytic hepatitis

a patient

pulse itraconazole therapy for 24 weeks

exposed to


Input: These findings should lead to further study of the role of lithium in the treatment of this symptom complex in patients with PTSD.

lithium

patients with PTSD

treatment


Input: She was placed on adjuvant Adriamycin (doxorubicin) chemotherapy, but 6 months later died of Adriamycin toxicity.

adjuvant Adriamycin (doxorubicin) chemotherapy

died of Adriamycin toxicity

She

toxicity


Input: BACKGROUND: Ovarian cancer arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy is rare.

Ovarian cancer

a postmenopausal woman

tamoxifen

arising


Input: L-asparaginase-induced pancreatitis is an uncommon but potential lethal complication of the treatment of leukemia.

L-asparaginase

pancreatitis

uncommon

potential lethal

induced


Input: An 89-year-old man receiving long-term anticoagulation with warfarin sodium (total weekly dosage of 19 mg) arrived at the anticoagulation clinic for his monthly visit.

An 89-year-old man

long-term anticoagulation with warfarin sodium (total weekly dosage of 19 mg)

receiving


Input: Treatment with tifacogin had no effect on all-cause mortality in patients with severe sepsis and high INR.

patients with severe sepsis and high INR

tifacogin

mortality

no

effect


Input: Although lung specimens were lacking from these three patients, it is suggested that the pulmonary toxicity of CCNU may be dose-related.

pulmonary toxicity

three patients

CCNU

may

related


Input: Concomitant use of clarithromycin or other potent inhibitors of CYP3A4 with repaglinide may enhance its blood glucose-lowering effect and increase the risk of hypoglycemia.

Concomitant use of clarithromycin or other potent inhibitors of CYP3A4 with repaglinide

blood glucose-lowering effect and increase the risk of hypoglycemia

may

enhance


Input: Drug-induced fever due to diltiazem.

diltiazem

fever

due to