Input: After therapy with parenteral amiodarone (2300 mg in 3 days) and other measures, signs of congestive heart failure disappeared; subsequently the patient developed jaundice, marked increase in serum transaminase levels and fall in prothrombin time, and histologic changes of severe centrilobular necrosis were observed in hepatic biopsy.

parenteral amiodarone (2300 mg in 3 days) and other measures

jaundice, marked increase in serum transaminase levels and fall in prothrombin time, and histologic changes of severe centrilobular necrosis were observed in hepatic biopsy

severe

After


Input: We report one case of non-Hodgkin lymphoma in a patient, with a 30-year history of rheumatoid arthritis, taking low dose methotrexate weekly over a 10-month period.

non-Hodgkin lymphoma

a patient, with a 30-year history of rheumatoid arthritis

low dose methotrexate weekly over a 10-month period

taking


Input: We recommend the cautious use of alum irrigation in patients with renal impairment and monitoring of serum aluminum levels to prevent excessive accumulation and toxicity.

patients

alum irrigation

excessive accumulation and toxicity.

to


Input: RESULTS: A 44-year-old man taking naproxen for chronic low back pain and a 20-year-old woman on oxaprozin for rheumatoid arthritis presented with tense bullae and cutaneous fragility on the face and the back of the hands.

a 20-year-old woman

oxaprozin

tense bullae and cutaneous fragility on the face and the back of the hands

presented

tense bullae and cutaneous fragility on the face and the back of the hands

A 44-year-old man

naproxen

presented


Input: CASE REPORT: We report a case of intracerebral hemorrhage occurring in a middle-aged man who suffered from chronic sinusitis and had been ingesting pseudoephedrine daily for one year.

intracerebral hemorrhage

middle-aged man who suffered from chronic sinusitis

ingesting pseudoephedrine daily for one year

occurring


Input: Lymphoma developing in a patient with rheumatoid arthritis taking methotrexate.

Lymphoma

a patient with rheumatoid arthritis

methotrexate

developing


Input: The Naranjo probability scale suggests a highly probable relationship between AIN and pantoprazole therapy in this patient.

AIN

pantoprazole

patient

highly probable

relationship


Input: In one case, disulfiram was the only potential teratogen exposed to the fetus.

disulfiram

teratogen

fetus

potential

exposed


Input: Pancreatitis has been noted to be a complication in 2-16% of patients undergoing treatment with L-asparaginase for a variety of pediatric neoplasms.

Pancreatitis

in 2-16% of patients

L-asparaginase for a variety of pediatric neoplasms

complication


Input: Myopathy, including rhabdomyolysis, is a well-known, albeit rare complication of statin therapy.

Myopathy, including rhabdomyolysis

statin

complication


Input: Management and successful desensitization in methotrexate-induced anaphylaxis.

methotrexate

anaphylaxis

induced


Input: Mitomycin-C induced hemolytic uremic syndrome: a case report.

Mitomycin-C

hemolytic uremic syndrome

induced


Input: Acute hepatic failure is a rare and potentially lethal complication of propylthiouracil (PTU) use for hyperthyroidism.

propylthiouracil (PTU)

Acute hepatic failure

complication


Input: Monoclonal gammopathy and subsequent multiple myeloma in a patient on chronic diphenylhydantoin therapy.

chronic diphenylhydantoin therapy.

a patient

Monoclonal gammopathy and subsequent multiple myeloma

on


Input: Unexpected severe reversible cyclosporine A-induced nephrotoxicity in a patient with systemic lupus erythematosus and tubulointerstitial renal disease.

cyclosporine A

nephrotoxicity

a patient with systemic lupus erythematosus and tubulointerstitial renal disease

severe

induced


Input: As far as we know, this is the first case report of acute hemorrhagic gastritis associated with AZ intoxication.

acute hemorrhagic gastritis

AZ intoxication

AZ

associated


Input: Toxic epidermal necrolysis resulted after 19 days of treatment with 5-fluorocytosine and amphotericin B.

19 days of treatment with 5-fluorocytosine and amphotericin B

Toxic epidermal necrolysis

after


Input: Since 1979, over 30 published case reports have documented the relationship between phenylpropanolamine and stroke.

phenylpropanolamine

stroke

relationship


Input: CASE SUMMARY: A 61-year-old woman with no apparent risk factors for liver injury developed acute hepatitis one week after the final dose of a long-term course of pulse itraconazole therapy (200 mg orally twice daily, 1 wk on, 3 wk off, for 24 wk) for onychomycosis.

A 61-year-old woman with no apparent risk factors for liver injury

acute hepatitis

long-term course of pulse itraconazole therapy (200 mg orally twice daily, 1 wk on, 3 wk off, for 24 wk)

developed


Input: We experienced a case of chronic renal failure in a patient suffering from acute hemorrhagic gastritis associated with AZ intoxication.

a case of chronic renal failure in a patient

acute hemorrhagic gastritis

AZ

associated with


Input: Rhabdomyolysis caused by tocolysis with oral ritodrine hydrochloride in a pregnant patient with myotonic dystrophy.

Rhabdomyolysis

tocolysis with oral ritodrine hydrochloride

a pregnant patient with myotonic dystrophy

caused


Input: While sulindac failed to affect significantly warfarin-induced hypoprothrombinemia in normal male volunteers, it markedly prolonged prothrombin time in a patient with a renal tubular defect who had been anticoagulated with warfarin.

markedly prolonged prothrombin time

a patient with a renal tubular defect

sulindac

had been anticoagulated with warfarin

in

warfarin

hypoprothrombinemia

induced

sulindac

affect significantly warfarin-induced hypoprothrombinemia

normal male volunteers

failed

affect


Input: Painful erosion of psoriatic plaques is a less common sign of methotrexate toxicity that may precede evidence of bone marrow suppression.

Painful erosion of psoriatic plaques

methotrexate toxicity

bone marrow suppression

methotrexate

sign


Input: Drug-induced hepatitis in an acromegalic patient during combined treatment with pegvisomant and octreotide long-acting repeatable attributed to the use of pegvisomant.

hepatitis

combined treatment with pegvisomant and octreotide long-acting repeatable

an acromegalic patient

induced


Input: We report the first case of a patient in a promethazine-induced coma responding to treatment with flumazenil.

a patient in a promethazine-induced coma

treatment with flumazenil

responding to


Input: Ocular hypertension occurred 1 month after the second ranibizumab injection in patients 1 and 3, and 1 month after the first ranibizumab in patient 2.

Ocular hypertension

1 month after the second ranibizumab injection

patients 1 and 3

in patient 2

occurred


Input: Priapism associated with zuclopenthixol.

zuclopenthixol

Priapism

associated


Input: Reversible MR imaging and MR spectroscopy abnormalities in association with metronidazole therapy.

Reversible MR imaging and MR spectroscopy abnormalities

metronidazole therapy

association


Input: PURPOSE: The aim of this study was to report on the possible development of corneal endothelial deposits resulting from the use of rifabutin.

corneal endothelial deposits

rifabutin

possible

resulting


Input: OBJECTIVE: To report a case of calcineurin-induced pain syndrome (CIPS) in a child undergoing his second hematopoietic stem cell transplant (HSCT).

calcineurin

pain syndrome (CIPS)

a child undergoing his second hematopoietic stem cell transplant (HSCT)

induced


Input: We experienced a male patient with psoriasis and hypertension whose conditions were treated with tacalcitol ointment and thiazide, respectively, resulting in hypercalciuria and hypercalcemia.

a male patient with psoriasis and hypertension

tacalcitol ointment and thiazide

hypercalciuria and hypercalcemia

resulting


Input: To our knowledge, this is the first granulomatous reaction described after calcium hydroxylapatite injection.

granulomatous reaction

calcium hydroxylapatite injection

after


Input: Previous studies have demonstrated the interaction of MTX and a variety of non-steroidal, anti-inflammatory drugs (NSAIDs) with various clinical manifestations including acute renal failure, pancytopenia, vomiting, diarrhea, elevated liver transaminases, jaundice, mucosal ulcerations, and pyrexia.

MTX and a variety of non-steroidal, anti-inflammatory drugs (NSAIDs)

acute renal failure, pancytopenia, vomiting, diarrhea, elevated liver transaminases, jaundice, mucosal ulcerations, and pyrexia

manifestations


Input: We present a case report of a patient with alveolar hydatid disease, whose treatment with mebendazole was brief due to side effects of alopecia and granulocytopenia; and review the features of this disease which, with increasing international migration, may be encountered more frequently in Australia.

a patient with alveolar hydatid disease

mebendazole

alopecia and granulocytopenia

due


Input: Niacin causes a reversible toxic cystoid maculopathy that occurs in approximately 0.67% of patients taking high doses of the drug.

Niacin

high doses

reversible toxic cystoid maculopathy

approximately 0.67% of patients

causes


Input: When tuberculosis patients on isoniazid eat certain varieties of fish they may develop a histamine reaction.

histamine reaction

tuberculosis patients

isoniazid

may

develop


Input: CONCLUSIONS: Priapism is an uncommon but potentially serious adverse effect of zuclopenthixol that practitioners, as with many other antipsychotics, should be aware of.

Priapism

zuclopenthixol

potentially

serious

serious adverse effect


Input: To report a case of possible interaction of smokeless tobacco with warfarin in a patient treated after several thromboembolic events.

warfarin

possible interaction of smokeless tobacco with warfarin

treated


Input: Hepatotoxicity induced by cyproterone acetate: a report of three cases.

Hepatotoxicity

cyproterone acetate

induced by


Input: Neurotoxicity of intrathecal methotrexate: MR imaging findings.

Neurotoxicity

intrathecal methotrexate

of


Input: Isonicotinic acid hydrazide induced anagen effluvium and associated lichenoid eruption.

Isonicotinic acid hydrazide

anagen effluvium and associated lichenoid eruption

induced


Input: Only one case of severe symptomatic hepatitis occurring after pulse therapy with itraconazole for onychomycosis and requiring transplantation has been reported previously.

one case

severe symptomatic hepatitis

pulse therapy with itraconazole

occurring


Input: The elicitation of a movement disorder by trazodone: case report.

trazodone

movement disorder

by


Input: Pulmonary fibrosis subsequent to high doses of CCNU for chronic myeloid leukemia.

high doses of CCNU

Pulmonary fibrosis

subsequent


Input: PURPOSE/OBJECTIVES: To describe the pharmacogenetic syndrome of dihydropyrimidine dehydrogenase (DPD) deficiency, which predisposes patients with cancer to potentially lethal adverse reactions following 5-fluorouracil (5-FU)-based chemotherapy.

dihydropyrimidine dehydrogenase (DPD) deficiency

5-fluorouracil (5-FU)-based chemotherapy

lethal adverse reactions

predisposes


Input: We report a case of sustained hypotension after administration of parenteral verapamil.

sustained hypotension

administration of parenteral verapamil

after


Input: Methadone has two roles in human immunodeficiency viral infection: pain management and treatment of opioid abuse.

Methadone

pain management and treatment of opioid abuse

has two roles


Input: Each time he arrived at the anticoagulation clinic after his BCG therapy, his INR was supratherapeutic, except after his fourth treatment (INR of 2.5), which can be explained by residual effects from the phytonadione he received a week earlier.

BCG

phytonadione

INR was supratherapeutic

residual effects


Input: A 70-year-old man had been treated with warfarin for atrial fibrillation.

A 70-year-old man

warfarin

treated


Input: This is a case report of fatal cryptococcal meningitis in a child with systemic lupus erythematosus being treated with prednisolone and azathioprine.

fatal cryptococcal meningitis

a child with systemic lupus erythematosus

prednisolone and azathioprine

in


Input: Acute hemorrhagic gastritis associated with acetazolamide intoxication in a patient with chronic renal failure.

Acute hemorrhagic gastritis

acetazolamide

a patient with chronic renal failure

associated


Input: Although the movement disorder could not with certainty be attributed to trazodone alone, the drug at least acted as an eliciting agent.

movement disorder

trazodone

attributed


Input: CONCLUSIONS: Prolonged exposure to itraconazole, administered either continuously or intermittently, may precipitate severe and irreversible hepatotoxic events.

severe and irreversible hepatotoxic events

Prolonged exposure to itraconazole, administered either continuously or intermittently

may

precipitate


Input: In two patients with mycosis fungoides, a squamous cell carcinoma developed during therapy with psoralens plus long-wave ultraviolet radiation (PUVA).

two patients with mycosis fungoides

psoralens plus long-wave ultraviolet radiation (PUVA)

squamous cell carcinoma

developed


Input: Scrotal ulceration induced by all-trans retinoic acid in a patient with acute promyelocytic leukemia.

a patient with acute promyelocytic leukemia.

all-trans retinoic acid

Scrotal ulceration

induced


Input: A 61 year-old male patient developed gynecomastia after starting theophylline.

A 61 year-old male patient

gynecomastia

theophylline

developed


Input: Several possible explanations of the mechanism of renal failure associated with the use of dextran-40 are discussed.

renal failure

associated


Input: We present a case of the syndrome of inappropriate antidiuretic hormone (SIADH) secondary to cisplatin therapy in a patient with advanced-stage large cell neuroendocrine carcinoma of the cervix.

a patient with advanced-stage large cell neuroendocrine carcinoma of the cervix

syndrome of inappropriate antidiuretic hormone (SIADH)

cisplatin therapy

secondary


Input: An 80-year-old white female, followed up at the Memory Clinic for mild cognitive impairment, had been taking propafenone 900 mg/d for >10 years for paroxysmal atrial fibrillation without adverse effects.

An 80-year-old white female

propafenone 900 mg/d for >10 years

for


Input: A total of 109 patients had a cardiovascular event, with event rates of 4.9% with omeprazole and 5.7% with placebo (hazard ratio with omeprazole, 0.99; 95% CI, 0.68 to 1.44; P = 0.96); high-risk subgroups did not show significant heterogeneity.

cardiovascular event

4.9% with omeprazole and 5.7% with placebo

109 patients

had


Input: The mechanism of anaphylactoid reaction to zomepirac in this case, therefore, remains unclear.

zomepirac

anaphylactoid

remains unclear

reaction


Input: New onset of CD may be considered as an immune-mediated injury induced by etanercept.

CD

immune-mediated injury

etanercept

induced


Input: This supports the well-reported potential of bleomycin to trigger acral vascular toxicity.

bleomycin

acral vascular toxicity

trigger


Input: Results of a Phase III, double-blind, randomized, parallel-group, non-inferiority study evaluating the safety and efficacy of isotretinoin-Lidose in patients with severe recalcitrant nodular acne.

patients with severe recalcitrant nodular acne

isotretinoin-Lidose

evaluating the safety and efficacy

of


Input: This treatment has the potential to cause severe vision loss as a result of intractable corticosteroid-induced glaucoma.

severe vision loss

glaucoma

corticosteroid

induced


Input: Therefore, parenteral amiodarone was implicated as the cause of acute hepatitis in this patient.

this patient

parenteral amiodarone

acute hepatitis

cause


Input: Twenty-four hours after the administration of gemcitabine, a symmetric, bullous, herpetiform eruption appeared on his trunk and upper limbs.

administration of gemcitabine

a symmetric, bullous, herpetiform eruption appeared on his trunk and upper limbs

after


Input: The rate of overt upper gastrointestinal bleeding was also reduced with omeprazole as compared with placebo (hazard ratio, 0.13; 95% CI, 0.03 to 0.56; P = 0.001).

omeprazole

reduced


Input: The association of phenothiazine overdose and respiratory distress syndrome merits consideration.

phenothiazine overdose

respiratory distress syndrome

association


Input: Patients from endemic areas referred to transplant centers may be at high risk for disseminated histoplasmosis when treated with long-term prednisone for graft-versus-host disease.

Patients

disseminated histoplasmosis

long-term prednisone

with


Input: Atypical endometriosis may act as a precancerous lesion in the process of tamoxifen-induced malignant transformation of endometriosis.

malignant transformation of endometriosis

tamoxifen

induced


Input: A 28 year old white schizophrenic male has been under risperidone monotherapy for about one year when he developed dyskinetic movements.

A 28 year old white schizophrenic male

risperidone monotherapy

dyskinetic movements

developed


Input: Subjects receiving ivacaftor were 55% less likely to have a pulmonary exacerbation than were patients receiving placebo, through week 48 (P<0.001).

ivacaftor

receiving

placebo

receiving


Input: Spinal cord infarction during use of zolmitriptan: a case report.

use of zolmitriptan

Spinal cord infarction

during


Input: Case 2, a 29-year-old woman, developed bilateral optic neuritis combined with numbness of the lower extremities as well as bowel and bladder dysfunction after a 22-month use of recombinant interferon alpha-2b for chronic myelogenous leukemia.

a 29-year-old woman

bilateral optic neuritis combined with numbness of the lower extremities as well as bowel and bladder dysfunction

22-month use of recombinant interferon alpha-2b

after


Input: These features have not previously been reported as side effects of glibenclamide therapy, but intrahepatic cholestasis may occur with chlorpropamide, a similar sulphonylurea agent.

intrahepatic cholestasis

chlorpropamide

may

occur


Input: Risperidone-induced tardive dyskinesia.

tardive dyskinesia

Risperidone

induced


Input: Caution in longterm usage and early recognition of pentazocine toxicity as a neuromuscular complication are important in order to prevent irreversible drug-induced fibrous myopathy and localized neuropathy.

pentazocine

toxicity

complication


Input: Based upon the observed fall of the filtration fraction, the rise in the relative clearance of 99Tc-dimercaptosuccinic acid and the increase in proteinuria, we suggest that in this case the tubules and/or interstitium are the main targets for cyclosporine A nephrotoxicity.

fall of the filtration fraction, the rise in the relative clearance of 99Tc-dimercaptosuccinic acid and the increase in proteinuria

cyclosporine A

suggest

observed


Input: Niacin maculopathy.

Niacin

maculopathy

maculopathy


Input: We report a case in which a potential drug interaction between clobazam and etravirine may have led to increased concentrations of clobazam and its pharmacologically active metabolite, N-desmethylclobazam, causing neurotoxic symptoms.

interaction between clobazam and etravirine

increased concentrations of clobazam and its pharmacologically active metabolite, N-desmethylclobazam

neurotoxic symptoms

potential

may

led


Input: A review of the literature revealed two other cases of hepatic angiosarcoma in patients after long-term cyclophosphamide treatment.

hepatic angiosarcoma

patients

long-term cyclophosphamide treatment

after


Input: We present a case of cutaneous leucocytoclastic vasculitis in which amphotericin B might presumably be the aetiological factor.

a case

cutaneous leucocytoclastic vasculitis

amphotericin B

might presumably

be


Input: There have been numerous case reports of hyperglycemia with olanzapine in the literature, but none reported hyperglycemia within days of initiation of the medication.

hyperglycemia

olanzapine

with


Input: This case report describes two severe antiretroviral drug adverse reactions that occurred in the same patient.

same patient

antiretroviral drug

adverse reactions

severe

occurred


Input: We report the first case presenting with successive anaphylactic reaction and extra-pyramidal syndrome after treatment with thiethylperazine maleate (thiethylperazine).

successive anaphylactic reaction and extra-pyramidal syndrome

treatment with thiethylperazine maleate (thiethylperazine)

after


Input: Renal failure associated with the use of dextran-40.

Renal failure

associated


Input: Acute lung injury associated with 5-fluorouracil and oxaliplatinum combined chemotherapy.

Acute lung injury

5-fluorouracil and oxaliplatinum combined chemotherapy

associated


Input: Type II heparin-induced thrombocytopenia (HIT) is an immunological disorder characterized by antibodies to heparin-platelet factor 4 complexes and a high risk of thrombotic complications.

Type II heparin

thrombocytopenia

induced


Input: RESULTS: Similar to previous findings of drug-induced vortex keratopathy, atovaquone vortex keratopathy is presumably caused by its lipophilic properties.

atovaquone

its lipophilic properties

vortex keratopathy

presumably

caused


Input: Gangrene of the fingertips after bleomycin and methotrexate.

Gangrene of the fingertips

bleomycin and methotrexate

after


Input: These cases demonstrate that CBZ can induce simple motor tics in children.

CBZ

simple motor tics

children

induce


Input: Esophageal spasm following propranolol overdose relieved by glucagon.

Esophageal spasm

propranolol overdose

following


Input: She was thus diagnosed as having AZ intoxication.

She

AZ

AZ intoxication

having


Input: Severe rhabdomyolysis following massive ingestion of oolong tea: caffeine intoxication with coexisting hyponatremia.

caffeine intoxication with coexisting hyponatremia

massive ingestion of oolong tea

Severe

following


Input: The ulcer did not respond to antibiotic treatment and healed shortly after withholding ATRA.

antibiotic treatment

not

respond

withholding ATRA

healed


Input: Gemfibrozil-warfarin drug interaction resulting in profound hypoprothrombinemia.

Gemfibrozil-warfarin drug interaction

profound hypoprothrombinemia

resulting


Input: Drug-induced eosinophilia is a non-dose-dependent side effect of clozapine.

eosinophilia

clozapine

induced


Input: Vortex keratopathy associated with atovaquone.

Vortex keratopathy

atovaquone

associated with


Input: DIAGNOSIS: Sustained ventricular tachycardia possibly owing to thalidomide treatment.

Sustained ventricular tachycardia

thalidomide

possibly

owing to


Input: In one instance a systemic hypoglycemic reaction resulting in head trauma and confusion ended in an emegency hospital admission following the substitution of acetohexamide for acetazolamide.

acetohexamide

systemic hypoglycemic reaction resulting in head trauma and confusion

following


Input: However, an association of Ritalin with glaucoma has been reported.

Ritalin

glaucoma

association


Input: After a two-month interruption of interferon administration, natural interferon alpha was given but followed by another episode of the same neurological manifestations.

interferon alpha

neurological manifestations

followed by


Input: This article discusses the clinical manifestations of the serotonin syndrome and highlights reported cases of serotonin syndrome specifically related to an interaction between SSRIs and fentanyl, a commonly used opioid in anesthesia practice.

serotonin syndrome

SSRIs and fentanyl

cases

related


Input: While the mechanism of dextran-associated renal failure remains unsolved, plasma exchange seems to be effective therapy.

dextran

renal failure

associated

plasma exchange

effective


Input: The use of pamidronate for hypercalcemia secondary to acute vitamin D intoxication.

pamidronate

for

vitamin D

hypercalcemia

secondary


Input: Early overanticoagulation with acenocoumarol due to a genetic polymorphism of cytochrome P450 CYP2C9.

acenocoumarol

Early overanticoagulation

with


Input: We report an unusual pattern of supravenous hyperpigmentation occurring after CHOP chemotherapy.

CHOP

supravenous hyperpigmentation

after


Input: Proton MRS examination demonstrated a persistent lactate elevation during metronidazole treatment.

persistent lactate elevation

metronidazole

during


Input: Encephalopathy and seizures induced by intravesical alum irrigations.

intravesical alum irrigations

Encephalopathy and seizures

induced


Input: Dermal side reactions to SSRI-drugs in these patients may be due to high activity in the serotonergic system at the dermal and epidermo-dermal junctional area rather than a hypersensitivity to the drug molecule itself.

Dermal side reactions

these patients

SSRI-drugs

to


Input: CASE SUMMARY: A febrile 36-year-old seaman from Mumbai (Bombay) was prescribed >5 times the usual dose of chloroquine for malaria diagnosed empirically onboard ship.

A febrile 36-year-old seaman from Mumbai (Bombay)

>5 times the usual dose of chloroquine

prescribed


Input: MATERIALS AND METHODS: We present two cases of significant morbidity related to primary and secondary perforation of the bladder following two instillations of epirubicin.

two instillations of epirubicin

two cases

significant morbidity related to primary and secondary perforation of the bladder

following


Input: Angio-oedema as an unusual tolerable side effect of voriconazole therapy.

Angio-oedema

voriconazole

as


Input: Oxycodone-gabapentin reduced pain score by 33% from baseline to end of treatment.

Oxycodone-gabapentin

reduced pain score by 33% from baseline

reduced


Input: OBJECTIVE: We report a patient who developed neutropenia on clozapine, but behind the cell count decrease showed to be a diurnal variation of the white blood cells (WBC).

neutropenia

diurnal variation of the white blood cells (WBC)

clozapine

a patient

developed


Input: RESULTS: Five of 70 patients who had begun leflunomide therapy had significant weight loss that could not be linked to other identifiable etiologies.

Five of 70 patients

leflunomide

significant weight loss

had


Input: Only one report links phenylpropanolamine consumption to an intracerebral hemorrhage in a patient with an AVM.

phenylpropanolamine

intracerebral hemorrhage

a patient with an AVM

links


Input: Anaphylactic reaction and unrelated, subsequent, known side effects during therapy with thiethylperazine.

thiethylperazine

Anaphylactic reaction

during


Input: PURPOSE: To investigate the concentration-side effect relationship in a patient with severe acyclovir-induced neurotoxicity and to summarize the information available in the literature about central nervous system side effects due to acyclovir.

acyclovir

neurotoxicity

central nervous system side effects

severe

induced


Input: Radiation recall from gemcitabine is rare, but can potentially arise in any site that has been previously irradiated.

Radiation recall

gemcitabine

from


Input: Most cases of pancreatitis associated with L-asparaginase toxicity are self-limiting and respond favorably to nasogastric decompression and intravenous hyperalimentation.

pancreatitis

L-asparaginase

Most cases

associated


Input: Shortly after commencing the drug, the patient developed a severe adverse drug reaction manifesting as Drug Reaction (or Rash) with Eosinophilia and Systemic Symptoms (DRESS) syndrome.

Shortly after commencing the drug

severe adverse drug reaction manifesting as Drug Reaction (or Rash) with Eosinophilia and Systemic Symptoms (DRESS) syndrome

the patient

developed


Input: This report presents a potential case of risperidone-induced tardive dyskinesia.

tardive dyskinesia

risperidone

a potential case

potential

induced


Input: The patient described feeling cold with worsening headache and chills approximately one hour after infusion of the first dose of penicillin.

feeling cold with worsening headache and chills

The patient

one hour after infusion of the first dose of penicillin

after


Input: Early-onset pentamidine-associated second-degree heart block and sinus bradycardia: case report and review of the literature.

Early-onset

second-degree heart block and sinus bradycardia

pentamidine

case

associated


Input: Fatal pulmonary fibrosis associated with BCNU: the relative role of platelet-derived growth factor-B, insulin-like growth factor I, transforming growth factor-beta1 and cyclooxygenase-2.

pulmonary fibrosis

BCNU

Fatal

associated


Input: CONCLUSIONS: This case suggests that losartan can induce late-onset angioedema in patients with normal renal function and that the reaction can recur after initial resolution of the symptoms.

losartan

late-onset angioedema

patients with normal renal function

induce


Input: Two cases of widespread cutaneous vasculitis are described in association with diltiazem, a recently introduced calcium antagonist.

diltiazem, a recently introduced calcium antagonist

widespread cutaneous vasculitis

widespread

association


Input: The incidence of angioedema secondary to losartan, an angiotensin II receptor antagonist, is unknown.

angioedema

losartan, an angiotensin II receptor antagonist

secondary


Input: We report the case of a young man, affected by rheumatoid arthritis who developed a rapid-onset short-of-breath, hemoptysis, and severe weakness, about 2 weeks after the administration of leflunomide.

a young man

a rapid-onset short-of-breath, hemoptysis, and severe weakness

about 2 weeks after the administration of leflunomide

severe

developed


Input: Toxicity related to chloroquine treatment of resistant vivax malaria.

Toxicity

chloroquine

related


Input: Patients with vitamin B12 deficiency are exceedingly sensitive to neurologic deterioration following nitrous oxide anesthesia.

Patients with vitamin B12 deficiency

neurologic deterioration

nitrous oxide anesthesia

following


Input: However here we reported two patients, presenting with PD during high dose colchicine treatment for familiar mediterranean fever (FMF).

high dose colchicine treatment

PD

two patients,

during


Input: We report two patients with infectious mononucleosis-like syndrome induced by salazosulfapyridine (SASP).

salazosulfapyridine (SASP).

two patients

infectious mononucleosis-like syndrome

induced


Input: Myocardial ischemia associated with high-dose carmustine infusion.

Myocardial ischemia

high-dose carmustine infusion

associated


Input: Hepatic drug interaction between tacrolimus and lansoprazole in a bone marrow transplant patient receiving voriconazole and harboring CYP2C19 and CYP3A5 heterozygous mutations.

a bone marrow transplant patient receiving voriconazole and harboring CYP2C19 and CYP3A5 heterozygous mutations

tacrolimus and lansoprazole

voriconazole

Hepatic drug interaction

between


Input: Gabapentin withdrawal presenting as status epilepticus.

Gabapentin withdrawal

status epilepticus

presenting


Input: Atypical ventricular tachycardia (torsade de pointes) induced by amiodarone: arrhythmia previously induced by quinidine and disopyramide.

amiodarone

Atypical ventricular tachycardia (torsade de pointes)

induced


Input: Colchicine-induced rhabdomyolysis is a rare complication, and the postulated mechanisms and risk factors for this severe complication are discussed.

Colchicine

rhabdomyolysis

induced


Input: Spindle coma in benzodiazepine toxicity: case report.

benzodiazepine

Spindle coma

in


Input: A typical case of dextran-40 associated acute renal failure is presented.

acute renal failure

associated


Input: After the second infliximab infusion, he was found to have a severe transient neutropenia (0.5 x 10(9)/L).

infliximab

severe transient neutropenia (0.5 x 10(9)/L)

he

found


Input: Lithium for irritability in post-traumatic stress disorder.

Lithium

for


Input: Iatrogenic hypercalcemia due to vitamin D3 ointment (1,24(OH)2D3) combined with thiazide diuretics in a case of psoriasis.

Iatrogenic hypercalcemia

vitamin D3 ointment (1,24(OH)2D3) combined with thiazide diuretics

due


Input: A case of mania associated with fluoxetine.

A case

mania

fluoxetine

associated


Input: RESULTS: Extensive squamous metaplasia was found in endometrial glands following progestin therapy.

progestin therapy

Extensive squamous metaplasia was found in endometrial glands

following


Input: Acute generalized exanthematous pustulosis caused by morphine, confirmed by positive patch test and lymphocyte transformation test.

Acute generalized exanthematous pustulosis

morphine

caused


Input: Eleven days after initiation of therapy with amiodarone, the patient experienced syncope and was noted to have recurrent episodes of polymorphous ventricular tachycardia.

Eleven days after initiation of therapy with amiodarone

the patient

syncope and was noted to have recurrent episodes of polymorphous ventricular tachycardia

experienced


Input: Prolonged used of hydroxyurea in patients with ET may lead to therapy-associated acute leukemia.

hydroxyurea

patients with ET

therapy-associated acute leukemia

may

associated


Input: Metastatic osteomyelitis following BCG vaccination.

Metastatic osteomyelitis

BCG vaccination

following


Input: Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma.

valproic acid

coma

Carbamyl phosphate synthetase-1 deficiency

induced


Input: We describe two patients in whom painful erosions of their psoriasis developed as the presenting sign of methotrexate toxicity and review the literature, emphasizing the risk factors associated with this manifestation.

two patients

painful erosions of their psoriasis

methotrexate

of


Input: Methysergide-induced retroperitoneal fibrosis: successful outcome and two new laboratory features.

Methysergide

retroperitoneal fibrosis

induced


Input: We describe 2 children with cerebral palsy who suffered significant morbidity immediately after treatment with hyperbaric oxygen.

significant morbidity immediately

2 children with cerebral palsy

treatment with hyperbaric oxygen

significant

suffered


Input: A patient is described with polycythemia vera who was taking anticoagulants and developed a spontaneous retropharyngeal hemorrhage after a violent sneezing episode.

anticoagulants

polycythemia vera

a spontaneous retropharyngeal hemorrhage after a violent sneezing episode

A patient

developed


Input: CD4 T-lymphocyte depletion, myelosuppression, and subsequent severe infections are the major side effects of fludarabine phosphate therapy.

fludarabine phosphate

CD4 T-lymphocyte depletion, myelosuppression, and subsequent severe infections

severe

of


Input: Penicillin-induced Jarisch-Herxheimer reaction.

Penicillin

Jarisch-Herxheimer reaction

induced


Input: The authors suggest that risperidone may increase affect in patients with schizophrenia and that some patients, especially those with anxiety, may have difficulty managing the increase.

risperidone

patients with schizophrenia

increase affect

may

increase


Input: We cared for a patient with progressive renal impairment who presented with blurred vision, QRS broadening and cardiac failure due to chronic cibenzoline intoxication.

blurred vision, QRS broadening and cardiac failure

chronic cibenzoline intoxication

a patient with progressive renal impairment

due


Input: In a postoperative patient with pre-existent myasthenia gravis, oral verapamil caused a marked exacerbation in myasthenic weakness.

a postoperative patient with pre-existent myasthenia gravis

oral verapamil

marked exacerbation in myasthenic weakness

marked

caused


Input: An objective causality assessment suggests that the JHR in our patient was probably related to penicillin.

JHR

patient

penicillin

probably

related


Input: RESULTS: A 34-year-old man acquired visual field defects and severe vision loss in both eyes after intravitreal injection of triamcinolone for diabetic macular edema.

intravitreal injection of triamcinolone

A 34-year-old man

visual field defects and severe vision loss in both eyes

severe

after


Input: Simvastatin-amiodarone interaction resulting in rhabdomyolysis, azotemia, and possible hepatotoxicity.

Simvastatin-amiodarone interaction

rhabdomyolysis, azotemia, and possible hepatotoxicity

resulting


Input: A 73-year-old woman receiving high-dosage olanzapine for bipolar disorder developed parkinsonism after smoking cessation.

parkinsonism

A 73-year-old woman

high-dosage olanzapine

smoking cessation

after


Input: Fatal pulmonary fibrosis induced by paclitaxel: a case report and review of the literature.

pulmonary fibrosis

paclitaxel

Fatal

induced


Input: Raltegravir-induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome - implications for clinical practice and patient safety.

Raltegravir

Eosinophilia and Systemic Symptoms (DRESS) syndrome

induced


Input: A 10-year-old boy with osteosarcoma and normal renal function manifested laboratory evidence of impending renal toxicity and extreme elevation of aspartate aminotrasferase and alanine aminotransferase within 2 hours after the completion of a 4-hour infusion of high-dose methotrexate (MTX) (12 g/m2), and went on to develop acute renal failure with life-threatening hyperkalemia 29 hours later.

10-year-old boy with osteosarcoma and normal renal function

impending renal toxicity and extreme elevation of aspartate aminotrasferase and alanine aminotransferase

acute renal failure with life-threatening hyperkalemia 29 hours later

4-hour infusion of high-dose methotrexate (MTX) (12 g/m2)

life-threatening

develop


Input: Transient trazodone-induced hypomanic symptoms occurred in three depressed patients.

three depressed patients

trazodone

hypomanic symptoms

induced


Input: We describe a case of disseminated muscular cysticercosis followed by myositis (fever, diffuse myalgia, weakness of the lower limbs, and inflammatory reaction around dying cysticerci) induced by praziquantel therapy, an event not described previously.

a case

disseminated muscular cysticercosis followed by myositis (fever, diffuse myalgia, weakness of the lower limbs, and inflammatory reaction around dying cysticerci)

praziquantel therapy

induced


Input: Drug-induced fever should be considered in patients who have unexplained high temperatures during diltiazem therapy.

fever

unexplained high temperatures

diltiazem therapy

induced


Input: Hemodialysis was also shown to reverse ifosfamide-related neurotoxicity.

ifosfamide

neurotoxicity

related

Hemodialysis

reverse


Input: Palpable purpuric skin lesions on the anterior surface of both legs appeared on the 55th day of amphotericin B treatment.

Palpable purpuric skin lesions on the anterior surface of both legs

55th day of amphotericin B treatment

appeared


Input: Transient left homonymous hemianopsia and encephalopathy following treatment of testicular carcinoma with cisplatinum, vinblastine, and bleomycin.

cisplatinum, vinblastine, and bleomycin

Transient left homonymous hemianopsia and encephalopathy

following


Input: We report a 46-yr-old woman with ovarian carcinoma who developed porphyria cutanea tarda while undergoing treatment with cisplatin and cyclophosphamide.

a 46-yr-old woman with ovarian carcinoma

porphyria cutanea tarda

cisplatin and cyclophosphamide

developed


Input: In one child, a second course of carbamazepine resulted in a return of the dystonia.

one child

a second course of carbamazepine

a return of the dystonia

resulted


Input: Does acyclovir increase serum lithium levels?

acyclovir

lithium

serum lithium levels

Does

increase


Input: Sulfadiazine crystalluria revisited.

Sulfadiazine

crystalluria

revisited


Input: Administration of sumatriptan in subarachnoid haemorrhage (SAH) patients, misdiagnosed as migraine patients, may induce symptomatic cerebral vasospasm with potentially dangerous consequences.

sumatriptan

patients

symptomatic cerebral vasospasm

may

induce


Input: Six of 13 outpatients with schizophrenia who participated in a ten-week open trial of risperidone had an initial good response to the medication followed by development of intolerable affect, including feelings of agitation and depression and periods of crying and insomnia.

Six of 13 outpatients with schizophrenia

a ten-week open trial of risperidone

intolerable affect, including feelings of agitation and depression and periods of crying and insomnia

development


Input: Pulmonary edema during acute infusion of epoprostenol in a patient with pulmonary hypertension and limited scleroderma.

acute infusion of epoprostenol

a patient with pulmonary hypertension and limited scleroderma

during


Input: Recent reports have shown that Decadron (dexamethasone; Merck Sharp & Dohme, West Point, Pa) has a significant antiemetic effect on cisplatin-induced vomiting.

Decadron

antiemetic


Input: Pleuropulmonary fibrosis after long-term treatment with the dopamine agonist pergolide for Parkinson Disease.

long-term treatment with the dopamine agonist pergolide

Pleuropulmonary fibrosis

after


Input: An infertile patient with amenorrhea-galactorrhea syndrome lost vision during a pregnancy occurring after Bromocryptine treatment.

Bromocryptine

lost vision

An infertile patient with amenorrhea-galactorrhea syndrome

after


Input: CONCLUSIONS: The observation that neurotoxicity developed with a delay of 24 to 48 hours after acyclovir peak serum concentrations could explain the wide range of acyclovir levels reported in similar cases.

neurotoxicity

acyclovir

developed


Input: Two cases of mequitazine-induced photosensitivity reactions.

mequitazine

photosensitivity reactions

induced


Input: Rhabdomyolysis associated with clozapine treatment in a patient with decreased calcium-dependent potassium permeability of cell membranes.

clozapine

Rhabdomyolysis

a patient with decreased calcium-dependent potassium permeability of cell membranes

with


Input: A 47 year-old woman who had a 4-year history of intramuscular pentazocine injections in the lower extremities, developed gradual stiffness and weakness of the lower extremities.

A 47 year-old woman

a 4-year history of intramuscular pentazocine injections in the lower extremities

gradual stiffness and weakness of the lower extremities

developed


Input: The possibility of severe rhabdomyolysis should be considered in a patient with water intoxication due to massive ingestion of caffeine-containing beverages.

a patient

massive ingestion of caffeine-containing beverages

severe rhabdomyolysis

water intoxication

severe

due to


Input: CASE SUMMARY: A 25-year-old postpartum white woman developed multiple watery stools and abdominal cramping on day 6 of therapy with clindamycin vaginal cream for bacterial vaginosis.

A 25-year-old postpartum white woman

multiple watery stools and abdominal cramping

clindamycin vaginal cream for bacterial vaginosis

developed


Input: Dose-dependent olanzapine-associated leukopenia: three case reports.

leukopenia

olanzapine

three case

associated


Input: He became completely premorbid 2 weeks after administration of levodopa.

levodopa

premorbid

He

after


Input: The authors describe a case of interstitial granulomatous dermatitis associated with darifenacin.

interstitial granulomatous dermatitis

darifenacin

associated


Input: Amiodarone was the third drug to induce AVT in this patient; she received 200 mg/day six days per week for six months.

Amiodarone

200 mg/day six days per week for six months

AVT

patient

she

induce


Input: A young diamond dealer developed visual impairment attributed to bilateral posterior subcapsular cataracts following only four courses of intermittent Decadron used as part of a five-drug antiemetic regimen for cisplatin-associated nausea.

A young diamond dealer

visual impairment attributed to bilateral posterior subcapsular cataracts

only four courses of intermittent Decadron used as part of a five-drug antiemetic regimen

following


Input: OBJECTIVE: To report a case of angioedema associated with losartan administration.

a case

angioedema

losartan administration

associated


Input: The authors present a case report of a granulomatous reaction leading to urethral prolapse, 3 months after the transurethral injection of calcium hydroxylapatite.

granulomatous reaction

urethral prolapse

3 months after the transurethral injection of calcium hydroxylapatite

a case report

leading


Input: Epstein-Barr virus-associated lymphoproliferative disorder in a patient with rheumatoid arthritis on methotrexate and rofecoxib: idiosyncratic reaction or pharmacogenetics?

Epstein-Barr virus-associated lymphoproliferative disorder

a patient with rheumatoid arthritis

methotrexate and rofecoxib

in


Input: On the other hand, aspirin may have promoted the enlargement of spontaneous hemorrhage from meningioma.

aspirin

enlargement of spontaneous hemorrhage from meningioma

may

promoted


Input: The two groups did not differ significantly in the rate of serious adverse events, though the risk of diarrhea was increased with omeprazole.

omeprazole

risk of diarrhea was increased

increased


Input: Treatment of a patient with severe digitoxin intoxication by Fab fragments of anti-digitalis antibodies.

Fab fragments of anti-digitalis antibodies

a patient with severe digitoxin intoxication

severe

Treatment


Input: Development of porphyria cutanea tarda after treatment with cyclophosphamide.

porphyria cutanea tarda

cyclophosphamide

after


Input: We report a premature infant who developed seizures associated with intraventricular administration of nafcillin and discuss the need for electroencephalographic monitoring of patients receiving intraventricular antibiotics.

intraventricular administration of nafcillin

seizures

a premature infant

associated with


Input: OBJECTIVE: To present a single case of zuclopenthixol-induced priapism and a literature review.

zuclopenthixol

priapism

induced


Input: CASE REPORT: We hereby report a case of radiation recall dermatitis and myositis occurring on gemcitabine monotherapy, five months after completing chemoradiation for locally advanced pancreatic cancer.

radiation recall dermatitis and myositis

gemcitabine monotherapy, five months after completing chemoradiation

occurring


Input: Stroke-like syndrome after gold sodium thiomalate induced vasomotor reaction.

vasomotor reaction

Stroke-like syndrome

gold sodium thiomalate

after


Input: MTX-induced hepatic injury and liver enzyme elevations have been demonstrated after treatment of leukemia, gestational disease and during treatment of psoriasis and rheumatoid arthritis.

MTX

hepatic injury and liver enzyme elevations

induced

treatment of leukemia, gestational disease and during treatment of psoriasis and rheumatoid arthritis

demonstrated


Input: An adverse drug reaction (ADR) induced by fluoxetine was suspected and fluoxetine treatment was discontinued.

An adverse drug reaction (ADR)

fluoxetine

suspected

induced


Input: New onset of Crohn's disease during treatment of active ankylosing spondylitis with etanercept.

etanercept

New onset of Crohn's disease

during


Input: Fatal hepatitis after long-term pulse itraconazole treatment for onychomycosis.

long-term pulse itraconazole treatment

Fatal hepatitis

Fatal

after


Input: Fatal outcome of intravesical formalin instillation, with changes mimicking renal tuberculosis.

intravesical formalin instillation

with changes mimicking renal tuberculosis

Fatal outcome

Fatal

of


Input: Both reactions were caused due to this anti-emetic drug, but an additive effect of clemastine fumarate, prescribed to treat the anaphylactic reaction, is suggested by the sequence of events.

clemastine fumarate

additive effect

suggested


Input: Reversible posterior leukoencephalopathy syndrome in systemic lupus erythematosus with thrombocytopenia treated with cyclosporine.

cyclosporine

treated


Input: Among patients receiving aspirin and clopidogrel, prophylactic use of a PPI reduced the rate of upper gastrointestinal bleeding.

PPI

reduced the rate of upper gastrointestinal bleeding

patients receiving aspirin and clopidogrel

prophylactic use


Input: Clofazimine enteropathy in a pediatric bone marrow transplant recipient.

a pediatric bone marrow transplant recipient

Clofazimine

enteropathy

in


Input: Anisocoria from transdermal scopolamine.

Anisocoria

transdermal scopolamine

from


Input: His fever resolved, but he developed symptoms consistent with those of chloroquine toxicity.

symptoms consistent with those of chloroquine toxicity

chloroquine

he

developed


Input: A 36-year-old man being treated with cisplatinum, vinblastine, and bleomycin for testicular carcinoma developed a dense left homonymous hemianopsia, encephalopathy, and a partial nondominant parietal lobe syndrome.

A 36-year-old man

testicular carcinoma

cisplatinum, vinblastine, and bleomycin

dense left homonymous hemianopsia, encephalopathy, and a partial nondominant parietal lobe syndrome

developed


Input: We report the first death associated with rhabdomyolysis in a patient treated with a statin and a protease inhibitor, which produced a significant drug-drug interaction.

a patient

a statin and a protease inhibitor

death associated with rhabdomyolysis

significant

treated


Input: Methotrexate (MTX) is a commonly used second line agent for RA, and there have been several recent reports of Epstein-Barr virus (EBV)-associated polyclonal B cell lymphoproliferative disorder in MTX-treated RA patients.

RA patients

MTX-treated

Epstein-Barr virus (EBV)-associated polyclonal B cell lymphoproliferative disorder

reports


Input: To describe a case of azathioprine-induced warfarin resistance, present a literature review on warfarin-azathioprine interactions, and provide recommendations on appropriate management of this clinically significant interaction.

azathioprine

warfarin resistance

induced


Input: Pulmonary fibrosis is a complication of paclitaxel therapy that may occur despite treatments with corticosteroids.

paclitaxel therapy

Pulmonary fibrosis

complication


Input: Two patients with adrenal carcinoma treated with 2,2-bis (2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane (o,p'-DDD) as adjuvant therapy were studied.

Two patients with adrenal carcinoma

2,2-bis (2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane (o,p'-DDD) as adjuvant therapy

treated


Input: METHODS: Repeated blood samples were drawn in a patient with severe acyclovir overdose who developed coma and nonoliguric renal failure.

coma and nonoliguric renal failure

a patient

acyclovir overdose

severe

developed


Input: An 8-year-old girl, who had been vaccinated with BCG without subsequent regional reactions, developed osteomyelitis in the left calcaneus 7 months later.

8-year-old girl

osteomyelitis

BCG

developed


Input: Since this amount of FAB was insufficient to bind all DGTX present in the serum, cardiac DGTX toxicity (total AV-block) persisted.

DGTX

cardiac DGTX toxicity (total AV-block)

persisted


Input: Abnormalities of the pupil and visual-evoked potential in quinine amblyopia.

amblyopia

Abnormalities of the pupil and visual-evoked potential

quinine

in


Input: A case is reported in which severe hypocalcemia, with a low plasma parathyroid hormone (PTH) concentration, resulted from the therapeutic use of magnesium sulfate for toxemia of pregnancy.

magnesium sulfate

severe hypocalcemia, with a low plasma parathyroid hormone (PTH) concentration

severe

resulted


Input: Concurrent acute megaloblastic anaemia and pneumonitis: a severe side-effect of low-dose methotrexate therapy during rheumatoid arthritis.

low-dose methotrexate

Concurrent acute megaloblastic anaemia and pneumonitis

severe

of


Input: Patients should be informed about the risk of osteonecrosis when taking dexamethasone as an antiemetic drug.

Patients

osteonecrosis

dexamethasone

risk


Input: We report a patient with inoperable pancreatic cancer who developed gastrointestinal bleeding secondary to radiation-recall related to gemcitabine and review literature.

gemcitabine

a patient with inoperable pancreatic cancer

gastrointestinal bleeding

radiation-recall

developed


Input: We report a case of SJS in a 14-year-old male with nephrotic syndrome, who was treated with oral prednisolone for 6 weeks.

a 14-year-old male

SJS

oral prednisolone for 6 weeks

with


Input: A 45-year-old woman with thyrotoxicosis developed agranulocytosis after treatment with propylthiouracil.

A 45-year-old woman with thyrotoxicosis

agranulocytosis

propylthiouracil

developed


Input: We wish to call for cautious approach at time of cessation of prolonged ACTH therapy because of possible unexpected and only partially understood hazardous side effects such as hyperkalemia.

cessation of prolonged ACTH

hyperkalemia

of


Input: Haemolytic-uraemic syndrome complicating long-term mitomycin C and 5-fluorouracil therapy for gastric carcinoma.

Haemolytic-uraemic syndrome

long-term mitomycin C and 5-fluorouracil therapy

complicating


Input: Although this article focuses on serotonin syndrome as a result of an adverse interaction of selective serotonin reuptake inhibitors (SSRI) and fentanyl, it is important for not only anesthesia professionals, but all clinicians--such as those in emergency medicine and critical care--to be aware of this syndrome and its management.

serotonin syndrome

selective serotonin reuptake inhibitors

fentanyl

result


Input: Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy are described in a 61-year-old diabetic patient who presented wit hypoglycaemic coma.

glibenclamide

Intrahepatic cholestasis and cutaneous bullae

a 61-year-old diabetic patient who presented wit hypoglycaemic coma

associated


Input: In the presented case, the temporal relationship between the administration of cloxacillin and increased INR suggests that the cloxacillin was responsible for the enhanced warfarin activity.

cloxacillin

enhanced warfarin activity.

increased INR

case

suggests

administration


Input: Cardiac arrest following use of sumatriptan.

Cardiac arrest

sumatriptan

following


Input: We report four cases of encephalopathy coincident with elevated aluminum levels as well as one patient who developed seizures while receiving continuous bladder irrigations with alum.

seizures

receiving continuous bladder irrigations with alum

one patient

developed


Input: Nine azotemic patients who developed a coagulopathy associated with the use of either cephalosporin or moxalactam antibiotics are reported.

Nine azotemic patients

coagulopathy

cephalosporin or moxalactam antibiotics

associated


Input: This report suggests that the poor prognosis previously given to fetuses exposed to disulfiram in the first trimester may not be warranted.

disulfiram

poor prognosis

fetuses

may

not

exposed


Input: We hypothesize that caffeine toxicity injured the muscle cells, which were fragile due to the potassium depletion induced by the coexisting hyponatremia, to result in unusually severe rhabdomyolysis.

caffeine toxicity

muscle cells, which were fragile due to the potassium depletion induced by the coexisting hyponatremia, to result in unusually severe rhabdomyolysis

hypothesize

injured


Input: The aim of this paper is to report the case of rosaceiform eruption induced by erlotinib in an 81-year-old-man and to discuss the pathogenetic role of Demodex folliculorum mites, found in the present patient, using skin scraping.

rosaceiform eruption

Demodex folliculorum mites

erlotinib

skin scraping

an 81-year-old-man

induced


Input: An 11-year-old boy developed a severe enteropathy 2 years after initiation of clofazimine treatment for graft-versus-host disease.

An 11-year-old boy

graft-versus-host disease

severe enteropathy

clofazimine treatment

developed


Input: The authors conclude that among patients taking high doses of oral niacin only those who experience visual symptoms need to be ophthalmologically evaluated.

high doses of oral niacin

visual symptoms

patients

taking


Input: Reflex sympathetic dystrophy syndrome in renal transplanted patients under immunosuppression with tacrolimus.

Reflex sympathetic dystrophy syndrome

renal transplanted patients

tacrolimus

with


Input: We report the case of an 11-year-old female treated for mediastinal T-cell lymphoma who presented renal failure following the second cycle of high-dose methotrexate (HDMTX).

an 11-year-old female treated for mediastinal T-cell lymphoma

renal failure

following the second cycle of high-dose methotrexate (HDMTX)

presented


Input: We report three cases of patients who developed leukopenia during olanzapine treatment.

three cases of patients

leukopenia

olanzapine treatment

developed


Input: Rapid onset of muscle weakness (rhabdomyolysis) associated with the combined use of simvastatin and colchicine.

Rapid onset of muscle weakness (rhabdomyolysis)

the combined use of simvastatin and colchicine

associated with


Input: A 35-year-old man with seropositive rheumatoid arthritis developed selective IgA deficiency during treatment with fenclofenac.

A 35-year-old man with seropositive rheumatoid arthritis

selective IgA deficiency

fenclofenac

during


Input: In this report, two newborns with congenital heart anomalies demonstrated the harlequin color change, one whose skin findings showed a course related to the dose of systemic prostaglandin E1, suggesting a possible association.

two newborns with congenital heart anomalies

harlequin color change

prostaglandin E1

possible association.

related


Input: Nonspecific but significant abnormalities have been described in the infants of women treated with disulfiram in the first trimester of their pregnancies.

disulfiram

abnormalities

infants

treated


Input: These data indicated that infliximab possibly triggered production of granulocyte and neutrophil autoantibodies with resultant autoimmune agranulocytosis.

infliximab

production of granulocyte and neutrophil autoantibodies with resultant autoimmune agranulocytosis

triggered


Input: Ovarian endometrioid adenocarcinoma arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy for breast cancer: a case report.

a postmenopausal woman

Ovarian endometrioid adenocarcinoma

tamoxifen therapy

under


Input: Tacrolimus-induced HUS: an unusual cause of acute renal failure in nephrotic syndrome.

Tacrolimus

HUS

induced


Input: OBJECTIVE: To report the clinical course of a woman with cryptococcal meningitis and no previous cardiac disease who developed a fatal cardiac arrhythmia after an acute overdose of amphotericin B and to review its toxicity.

a woman with cryptococcal meningitis and no previous cardiac disease

a fatal cardiac arrhythmia

an acute overdose of amphotericin B

developed


Input: We report a case of a bullous lichenoid eruption due to the intake of captopril.

bullous lichenoid eruption

captopril

a case

due


Input: The hypoadrenalism was overcome by increasing steroid replacement therapy.

increasing steroid replacement therapy

overcome


Input: DIAGNOSIS: Interferon alpha-2b-induced cardiomyopathy.

Interferon alpha-2b

cardiomyopathy

induced


Input: Choroidal hemorrhage associated with systemic tissue plasminogen activator.

systemic tissue plasminogen activator

Choroidal hemorrhage

associated


Input: Clozapine-induced eosinophilia and switch to quetiapine in a patient with chronic schizophrenia with suicidal tendencies.

Clozapine

eosinophilia

a patient with chronic schizophrenia with suicidal tendencies

induced

a patient with chronic schizophrenia with suicidal tendencies

quetiapine

switch


Input: Adverse effects of propafenone after long-term therapy with the addition of citalopram.

long-term therapy with the addition of citalopram

Adverse effects

after


Input: The case of an adult who developed both hepatic dysfunction and an impaired macrophage migration after exposure to cimetidine is discussed.

hepatic dysfunction and an impaired macrophage migration

cimetidine is discussed

an adult

developed


Input: We report 4 patients who developed symptoms of myasthenia gravis within 2 weeks of starting treatment with a statin drug.

4 patients

symptoms of myasthenia gravis

within 2 weeks of starting treatment with a statin

developed


Input: After only the third dose of pentamidine, it was noted that the patient's heart rate had decreased to 48 beats/minute.

third dose of pentamidine

patient's

heart rate had decreased to 48 beats/minute

After


Input: A 44-year-old woman is described in whom amiodarone, disopyramide, and quinidine, administered alone separately, induced atypical ventricular tachycardia (AVT, torsade de pointes).

A 44-year-old woman

amiodarone, disopyramide, and quinidine

atypical ventricular tachycardia (AVT, torsade de pointes)

induced


Input: Azathioprine was the probable causative agent of warfarin resistance according to the Naranjo probability scale, and a possible causative agent according to the Drug Interaction Probability Scale.

Azathioprine

warfarin resistance

probable

causative agent


Input: Disulfiram has been used effectively to deter alcohol consumption in patients with a history of alcohol abuse.

Disulfiram

patients with a history of alcohol abuse

used


Input: Nevirapine is a non-nucleoside reverse transcriptase inhibitor used in the treatment of human immunodeficiency virus (HIV)-infected patients and in post-exposure prophylaxis.

Nevirapine

human immunodeficiency virus (HIV)-infected patients

treatment


Input: Vasospasm associated with ergotamine is a well-known phenomenon.

Vasospasm

ergotamine

associated


Input: After a six-week course of low-dose cyclosporine A, she developed a severe but reversible loss of glomerular filtration rate and effective renal plasma flow despite of low cyclosporine A plasma levels.

After a six-week course of low-dose cyclosporine A

loss of glomerular filtration rate and effective renal plasma flow

severe

developed


Input: We report a case of severe simvastatin-induced rhabdomyolysis triggered by the addition of amiodarone to previously well-tolerated chronic statin therapy.

simvastatin

the addition of amiodarone to previously well-tolerated chronic statin therapy

rhabdomyolysis

severe

induced


Input: In January 2010, a 50-year-old transgender female with HIV infection and recurrent deep vein thrombosis began treatment with the TRIO study regimen.

a 50-year-old transgender female

TRIO

treatment


Input: In vitro inhibition of CYP2C9 by zafirlukast is consistent with clinical studies showing impaired clearance of  S-warfarin and enhanced anti-thrombotic effects, although the in vitro IC(50) value is higher than the usual range of clinically relevant plasma concentrations.

zafirlukast

impaired clearance of  S-warfarin and enhanced anti-thrombotic effects

consistent

showing


Input: Although it is difficult to solely attribute intratumoral hemorrhage to aspirin, we have to be careful when prescribing aspirin for patients who have asymptomatic meningioma.

patients who have asymptomatic meningioma

aspirin

intratumoral hemorrhage

difficult

attribute


Input: CONCLUSIONS: The fundus picture shown in these cases may be typical of ASPPC after IVTA injection.

ASPPC

IVTA injection

after


Input: The probable proarrhythmic action of amiodarone, although rare, is reviewed along with a discussion of the novel use of intravenous magnesium sulfate therapy.

proarrhythmic

amiodarone

action


Input: We present two cases of severe, atypical ASRs which occurred during NMSC treatment with imiquimod in the context of infliximab administration for psoriasis, and consider the grounds supporting a non-fortuitous association.

imiquimod in the context of infliximab administration

atypical ASRs

severe

occurred


Input: A case of propranolol overdose complicated by esophageal spasm preventing extrication of an orogastric lavage tube and relieved by intravenous glucagon is presented.

propranolol overdose

esophageal spasm preventing extrication of an orogastric lavage tube

complicated

intravenous glucagon

relieved


Input: Fenclofenac-induced selective IgA deficiency in rheumatoid arthritis.

Fenclofenac

selective IgA deficiency in rheumatoid arthritis

induced


Input: Naproxen, the most common offender, has been associated with a dimorphic clinical pattern: a PCT-like presentation and one simulating erythropoietic protoporphyria in the pediatric population.

Naproxen

erythropoietic protoporphyria

pediatric population

common

associated


Input: Zafirlukast is a cysteinyl leukotriene antagonist used to treat allergic and exercise-induced asthma.

Zafirlukast is a cysteinyl leukotriene antagonist

treat


Input: Rapidly developing hyperglycemia during treatment with olanzapine.

olanzapine

Rapidly developing hyperglycemia

during


Input: The first patient was a 61-year-old man with a 30-year history of fistulizing CD in whom B-cell non-Hodgkin's lymphoma was diagnosed 9 months after treatment with infliximab.

The first patient was a 61-year-old man with a 30-year history of fistulizing CD

B-cell non-Hodgkin's lymphoma

9 months after treatment with infliximab

diagnosed


Input: Recognition of a potential drug-induced Fanconi syndrome is important when managing pediatric oncology patients previously treated with ifosfamide.

drug-induced Fanconi syndrome

pediatric oncology patients

ifosfamide

potential

treated


Input: We report a patient with chronic renal failure and ischemic heart disease who developed clinically significant methemoglobinemia after an axillary block with bupivacaine and additional injection of lidocaine in the operative field.

a patient with chronic renal failure and ischemic heart disease

clinically significant methemoglobinemia

an axillary block with bupivacaine and additional injection of lidocaine in the operative field

developed


Input: Amikacin-induced type 5 Bartter-like syndrome with severe hypocalcemia.

Amikacin

type 5 Bartter-like syndrome with severe hypocalcemia

severe

induced


Input: L-asparaginase-induced severe necrotizing pancreatitis successfully treated with percutaneous drainage.

percutaneous drainage

treated

L-asparaginase

severe necrotizing pancreatitis

induced


Input: This report describes the first case of insulin-induced cardiac failure in a patient without underlying heart disease.

cardiac failure

insulin

a patient without underlying heart disease

induced


Input: OBJECTIVE: To determine the frequency of weight loss in patients treated with leflunomide for rheumatoid arthritis at an arthritis referral center.

weight loss

patients

leflunomide

loss


Input: INH, which is a leading cause of drug eruptions in the above group of drugs was withdrawn.

drug eruptions

INH

a leading cause


Input: Complications associated with primary and secondary perforation of the bladder following immediate instillations of epirubicin after transurethral resection of superficial urothelial tumours.

Complications associated with primary and secondary perforation of the bladder

instillations of epirubicin

following


Input: Ofloxacin: a probable cause of toxic epidermal necrolysis.

Ofloxacin

toxic epidermal necrolysis

probable

cause


Input: Fatal lung fibrosis caused by paclitaxel toxicity has not been reported In this report, we describe the case of a 62-year-old woman who received six cycles of paclitaxel and carboplatin as combination chemotherapy for advanced ovarian cancer.

62-year-old woman

advanced ovarian cancer

six cycles of paclitaxel and carboplatin as combination chemotherapy

Fatal lung fibrosis

received


Input: A 21-year-old patient developed rhabdomyolysis during his nineteenth week of treatment with clozapine for drug-resistant schizophrenia.

A 21-year-old patient

rhabdomyolysis

during his nineteenth week of treatment with clozapine

developed


Input: Cisplatin-induced syndrome of inappropriate antidiuretic hormone (SIADH) in a patient with neuroendocrine tumor of the cervix: a case report and review of the literature.

Cisplatin

syndrome of inappropriate antidiuretic hormone (SIADH)

a patient with neuroendocrine tumor of the cervix

induced


Input: Myoglobinuria and acute renal failure associated with intravenous vasopressin infusion.

Myoglobinuria and acute renal failure

intravenous vasopressin infusion

associated


Input: We report the first case of fulminant adult respiratory distress syndrome (ARDS) associated with pegylated interferon alpha-2a (pegIFNalpha-2a) and ribavirin use for hepatitis C, complicated by subsequent and ultimately fatal sepsis and multiorgan failure.

adult respiratory distress syndrome (ARDS)

pegylated interferon alpha-2a (pegIFNalpha-2a) and ribavirin

fatal

associated


Input: Catatonia associated with disulfiram therapy.

Catatonia

disulfiram therapy

associated


Input: To date, no relation has ever been suggested between TNF-alpha inhibitors and increased susceptibility to developing exaggerated ASRs with imiquimod.

TNF-alpha inhibitors

imiquimod

exaggerated ASRs

no

susceptibility

developing


Input: Losartan-induced angioedema.

angioedema

Losartan

induced


Input: However, dermatologists should be cautious about a photosensitivity reaction induced by mequitazine or other phenothiazine-derivative drugs.

photosensitivity

mequitazine

induced


Input: Oxycodone-gabapentin also significantly improved pain relief vs gabapentin alone (P = 0.003).

Oxycodone-gabapentin

improved


Input: In 2 of the 3 cases the patients were also taking lithium carbonate and beta-blockers, both of which could have contributed to the incontinence.

the patients

lithium carbonate and beta-blockers

incontinence

could

contributed


Input: Pulmonary fibrosis is a severe complication associated with bis-chloronitrosourea (BCNU) therapy.

Pulmonary fibrosis is a severe complication

bis-chloronitrosourea (BCNU) therapy

severe

associated


Input: We report here a 26-year-old female with diffuse large B-cell lymphoma who died of severe pulmonary fibrosis 81 days after the administration of high-dose BCNU (600 mg/m2).

26-year-old female with diffuse large B-cell lymphoma

high-dose BCNU (600 mg/m2)

died of severe pulmonary fibrosis

died

administration


Input: The patient was given methimazole instead of propylthiouracil but, 10 weeks later, agranulocytosis again occurred.

The patient

methimazole

agranulocytosis

occurred


Input: Three months after starting citalopram, she experienced episodes of chest tightness and dizziness.

citalopram

chest tightness and dizziness

she

experienced


Input: Although differential diagnostic alternatives can be considered in all described cases it is very likely that vincristine does cause severe visual loss in a small number of patients.

vincristine

severe visual loss

a small number of patients

severe

very likely

cause


Input: This case is remarkable since 1) ECM developed after subcutaneous and not after intramuscular injection, 2) the injection was given by the patient himself, and 3) glatiramer acetate can induce skin necrosis as a side effect.

glatiramer acetate

skin necrosis

induce


Input: SSRI-drugs increase serotonin concentrations and are known to have pruritus and other dermal side effects.

SSRI-drugs

increase serotonin concentrations

pruritus and other dermal side effects.

increase


Input: Dabigatran etexilate and concomitant use of non-steroidal anti-inflammatory drugs or acetylsalicylic acid in patients undergoing total hip and total knee arthroplasty: no increased risk of bleeding.

patients undergoing total hip and total knee arthroplasty

Dabigatran etexilate and concomitant use of non-steroidal anti-inflammatory drugs or acetylsalicylic acid

no increased risk of bleeding

no

in


Input: Our literature review revealed an additional six cases of onset of inflammatory arthritis in MS patients receiving IFN-beta.

inflammatory arthritis

receiving IFN-beta

six cases

in MS patients

onset


Input: Two years later, 24 hours following an increase in the dose of disopyramide from 300 to 600 mg/day, AVT with syncope occurred; isoproterenol abolished the arrhythmia instantly.

Two years later, 24 hours following an increase in the dose of disopyramide from 300 to 600 mg/day

AVT with syncope

occurred

isoproterenol

abolished


Input: The patient was initially treated with hydration and furosemide but developed congestive heart failure.

The patient

congestive heart failure

furosemide

developed


Input: We present an interesting case of an HIV-positive woman on antiretroviral therapy having tubal pregnancies on two separate occasions with Implanon in place.

an HIV-positive woman

antiretroviral

tubal pregnancies

having


Input: We hypothesize that decreased renal elimination of MTX induced by the COX-2 inhibitor resulted in enhanced hematopoietic toxicity and immunosuppression causing the EBV-associated lymphoproliferative disease.

MTX

enhanced hematopoietic toxicity and immunosuppression

causing the EBV-associated lymphoproliferative disease

resulted


Input: Temsirolimus-induced glomerulopathy.

Temsirolimus

glomerulopathy

induced


Input: OBJECTIVE: To report a case of linear immunoglobulin (Ig) A bullous dermatosis (LABD) induced by gemcitabine.

a case

linear immunoglobulin (Ig) A bullous dermatosis (LABD)

gemcitabine

induced


Input: This patient developed sequential symptoms including alternative hemiparesis, dysarthria and altered consciousness 5 days after the second course of HD-MTX (8 gm/m2 by 6 h continuous infusion) with leucovorin rescue.

patient

sequential symptoms including alternative hemiparesis, dysarthria and altered consciousness

the second course of HD-MTX (8 gm/m2 by 6 h continuous infusion) with leucovorin rescue

developed


Input: Adult and adolescent patients (> or = 12 years old; n = 141) with severe, persistent, oral steroid (prednisone)-dependent asthma.

Adult and adolescent patients

oral steroid (prednisone)

asthma

severe, persistent,

dependent


Input: DISCUSSION: Amphotericin B deoxycholate has been reported to produce significant cardiac toxicity, with ventricular arrhythmias and bradycardia reported in overdoses in children and in adults with preexisting cardiac disease, even when administered in conventional dosages and infusion rates.

Amphotericin B deoxycholate

conventional dosages and infusion rates

cardiac toxicity, with ventricular arrhythmias and bradycardia

in children and in adults with preexisting cardiac disease

produce


Input: Diarrhoea, T-CD4+ lymphopenia and bilateral patchy pulmonary infiltrates developed in a male 60 yrs of age, who was treated with oxaliplatinum and 5-fluorouracil for unresectable rectum carcinoma.

male 60 yrs of age

oxaliplatinum and 5-fluorouracil

Diarrhoea, T-CD4+ lymphopenia and bilateral patchy pulmonary infiltrates

developed


Input: Thus, tardive seizures in our cases are thought to be related to piperacillin and cefotiam.

tardive seizures

piperacillin and cefotiam

related


Input: A 55-yr-old man developed prolonged jaundice and sicca complex after a course of thiabendazole therapy.

A 55-yr-old man

a course of thiabendazole

prolonged jaundice and sicca complex

after


Input: Methylphenidate (Ritalin)-associated cataract and glaucoma.

Methylphenidate (Ritalin)

cataract and glaucoma

associated


Input: Simvastatin-nelfinavir interaction implicated in rhabdomyolysis and death.

Simvastatin-nelfinavir interaction

rhabdomyolysis and death

death

implicated


Input: Uncontrolled headache induced by oxcarbazepine.

Uncontrolled headache

oxcarbazepine

induced


Input: We now present four cases of RSDS in kidney transplant recipients treated with tacrolimus.

RSDS

four cases

kidney transplant recipients

tacrolimus

treated


Input: Transient neurological disturbances induced by the chemotherapy of high-dose methotrexate for osteogenic sarcoma.

Transient neurological disturbances

the chemotherapy of high-dose methotrexate

induced


Input: Long-term safety and efficacy in patients with uncontrolled partial-onset seizures treated with adjunctive lacosamide: results from a Phase III open-label extension trial.

patients with uncontrolled partial-onset seizures

adjunctive lacosamide

treated


Input: A variety of movement disorders are known to occur in association with carbamazepine (CBZ) therapy in adults and children, but development of tics has been described infrequently and only in patients with underlying Tourette's syndrome or other movement disorders.

movement disorders

carbamazepine (CBZ) therapy

adults and children

occur


Input: On the day before this visit, he had received the third of six serial weekly BCG bladder instillations for the treatment of bladder cancer.

he

bladder cancer

the third of six serial weekly BCG bladder instillations

received


Input: Following a closed mitral valvotomy, she received quinidine, 1.2 g/day, without interruption for 17 years.

quinidine, 1.2 g/day

received


Input: We describe a patient in whom noncardiogenic pulmonary edema developed during intrabiliary infusion of monooctanoin.

noncardiogenic pulmonary edema

intrabiliary infusion of monooctanoin

a patient

developed


Input: Mitomycin-C is used widely in the treatment of malignancies and is associated with serious dose related adverse effects including the occurrence of hemolytic uremic syndrome.

hemolytic uremic syndrome

Mitomycin-C

associated


Input: Valproic acid induced coma is presented in an adult patient without a history of metabolic disease.

Valproic acid

coma

adult patient without a history of metabolic disease

induced


Input: Three patients with no history of asthma or allergy developed bronchospasm while taking propranolol for hypertension.

Three patients with no history of asthma or allergy

bronchospasm

propranolol

developed


Input: To report two cases of warfarin therapy in which the addition of tolterodine resulted in prolonged international normalized ratios (INRs).

two cases

warfarin therapy in which the addition of tolterodine

prolonged international normalized ratios (INRs)

resulted


Input: In addition, an immediate erythematous macule was observed on the photopatch test site of mequitazine directly after UV exposure which was similar to the immediate erythema noted in chlorpromazine photoallergy.

an immediate erythematous macule

mequitazine directly after UV exposure

observed


Input: Acetazolamide-accelerated anticonvulsant osteomalacia.

Acetazolamide

anticonvulsant osteomalacia

accelerated


Input: Both patients suddenly became hypotensive after injection of chymopapain into a disk.

Both patients

hypotensive

injection of chymopapain into a disk

became


Input: Large dose of methylphenidate may cause cataract and glaucoma.

methylphenidate

cataract and glaucoma

may

cause


Input: Total blindness with a transient tonic pupillary response, denervation supersensitivity, and abnormal visual-evoked potentials developed in a 54-year-old man after the use of quinine sulfate for leg cramps.

quinine sulfate

Total blindness with a transient tonic pupillary response, denervation supersensitivity, and abnormal visual-evoked

a 54-year-old man

after


Input: Carbamazepine-induced tics.

Carbamazepine

tics

induced


Input: Three patients are reported without a history of angina pectoris who had clinical and electrocardiographic evidence of myocardial ischemia during and immediately after BCNU infusion.

Three patients are reported without a history of angina pectoris

myocardial ischemia

during and immediately after BCNU infusion

had


Input: A rare debilitating neurological adverse effect of ranolazine due to drug interaction with clarithromycin.

debilitating neurological

ranolazine

clarithromycin

adverse effect


Input: Septic knee arthritis after intra-articular hyaluronate injection.

Septic knee arthritis

intra-articular hyaluronate injection

after


Input: The concomitant use, however, of colchicine and statin has been associated with the rapid onset of muscle weakness.

colchicine and statin

the rapid onset of muscle weakness

associated


Input: Successful treatment of hyperthyroidism with amiodarone in a patient with propylthiouracil-induced acute hepatic failure.

amiodarone

a patient with propylthiouracil-induced acute hepatic failure

treatment

propylthiouracil

acute hepatic failure

induced


Input: Olanzapine-induced parkinsonism associated with smoking cessation.

associated with smoking cessation

Olanzapine

parkinsonism

induced


Input: CASE: We present an 11-year old male with Budd-Chiari syndrome who experienced profound worsening of chronic aphthous ulcers after immunosuppressive therapy was changed from tacrolimus to sirolimus.

an 11-year old male with Budd-Chiari syndrome

profound worsening of chronic aphthous ulcers

immunosuppressive therapy was changed from tacrolimus to sirolimus

profound

experienced


Input: We report the cases of two patients who developed acute hepatitis after taking riluzole at the recommended dose (100 mg daily) for 7 and 4 weeks, respectively.

riluzole at the recommended dose (100 mg daily) for 7 and 4 weeks

two patients

acute hepatitis

taking


Input: An interaction between levodopa and enteral nutrition resulting in neuroleptic malignant-like syndrome and prolonged ICU stay.

levodopa and enteral nutrition

neuroleptic malignant-like syndrome and prolonged ICU stay

resulting


Input: Until further data are available, clinicians should be vigilant for a possible drug interaction when tolterodine therapy is initiated in a patient maintained on warfarin therapy.

tolterodine therapy

possible drug interaction

a patient

possible

initiated


Input: The itch spread to the arms, abdomen and legs and the patient treated himself with clemastine and the itch disappeared.

clemastine

The itch spread to the arms, abdomen and legs and the patient

himself

itch disappeared

disappeared


Input: In this case report we present a rare drug interaction between erythromycin and ergotamine at normal doses causing lower extremity ischemia in a 36-year-old woman.

a rare drug interaction between erythromycin and ergotamine at normal doses

lower extremity ischemia

a 36-year-old woman

causing


Input: Neutropenia and agranulocytosis are risks known to occur with phenothiazines and clozapine.

phenothiazines and clozapine.

Neutropenia and agranulocytosis

risks

occur


Input: She had been taking rifampin prior to admission for acid-fast bacilli.

rifampin

She

taking


Input: The responsibility of CCNU in the pathogenesis of pulmonary fibrosis seems very likely.

CCNU

pathogenesis of pulmonary fibrosis

seems very likely

responsibility


Input: Malignant mixed mullerian tumor of the uterus in a patient taking raloxifene.

raloxifene

Malignant mixed mullerian tumor of the uterus

a patient

taking


Input: Fatal overdoses associated with quetiapine.

quetiapine

Fatal overdoses

Fatal

associated


Input: Gemcitabine-induced rectus abdominus radiation recall.

Gemcitabine

rectus abdominus radiation recall

induced


Input: We report on a serious side effect in a severely depressed 55-year-old woman, who presented an erythematous pigmented skin rash on the whole body under combination treatment with antidepressants, atypical antipsychotic drugs, the mood stabilizer lithium and the lipid-lowering drug pravastatin.

depressed 55-year-old woman

erythematous pigmented skin rash on the whole body

combination treatment with antidepressants, atypical antipsychotic drugs, the mood stabilizer lithium and the lipid-lowering drug pravastatin

presented


Input: We present a 20-year-old woman with Basedow-Graves' disease who developed PTU-induced fulminant hepatitis, which progressed to acute hepatic failure with grade III hepatic encephalopathy.

a 20-year-old woman with Basedow-Graves' disease

fulminant hepatitis, which progressed to acute hepatic failure with grade III hepatic encephalopathy

PTU

induced


Input: The European Organization for Research and Treatment of Cancer 58881 study was designed to test in a prospective multicentric randomized trial the value of high-dose (HD) intravenous (IV) cytarabine (Ara-C) added to HD IV methotrexate (MTX) to reduce the incidence of CNS and systemic relapses in children with increased-risk acute lymphoblastic leukemia (ALL) or stage III and IV lymphoblastic lymphoma treated with a Berlin-Frankfurt-Munster (BFM)-based regimen.

high-dose (HD) intravenous (IV) cytarabine (Ara-C) added to HD IV methotrexate (MTX)

reduce the incidence of CNS and systemic relapses

children with increased-risk acute lymphoblastic leukemia (ALL) or stage III and IV lymphoblastic lymphoma

test

to


Input: The authors postulate that two types of combined lithium-neuroleptic toxicity occur: a neuroleptic malignant extrapyramidal syndrome and a lithium toxicity that occurs in combination with phenothiazines, primarily thioridazine.

lithium

neuroleptic toxicity

occur

lithium

in combination with phenothiazines, primarily thioridazine

a neuroleptic malignant extrapyramidal syndrome and a lithium toxicity

occurs


Input: Trans-catheter hepatic arterial injection of lipiodol soluble anti-cancer agent SMANCS and ADR suspension in lipiodol combined with arterial embolization and local hyperthermia for treatment of hepatocellular carcinoma.

Trans-catheter hepatic arterial injection of lipiodol soluble anti-cancer agent SMANCS and ADR suspension in lipiodol combined with arterial embolization and local hyperthermia

treatment


Input: Gynecomastia associated with theophylline.

Gynecomastia

theophylline

associated


Input: Arthritis and bursitis in multiple sclerosis patients treated with interferon-beta.

multiple sclerosis patients

interferon-beta

treated


Input: To our knowledge, drug-induced fever has not been reported with the use of diltiazem hydrochloride, a commonly prescribed calcium channel blocker.

fever

drug

with the use of diltiazem hydrochloride, a commonly prescribed calcium channel blocker

not

induced


Input: Case studies in heparin-induced thrombocytopenia.

thrombocytopenia

heparin

induced


Input: We describe a 41 yr old leprosy patient treated for 10 yrs with clofazimine who underwent laparotomy for severe abdominal pain.

a 41 yr old leprosy patient

10 yrs with clofazimine

severe abdominal pain

severe

for


Input: Osteonecrosis is a serious side effect of antiemetic treatment with dexamethasone and this serious complication should be incorporated in the current guidelines.

Osteonecrosis

antiemetic treatment with dexamethasone

serious

side effect


Input: We report the development of scrotal ulcer in a patient with acute promyleocytic leukemia (APL) within 10 days of treatment with ATRA at a dose of 40 mg orally twice daily.

a patient with acute promyleocytic leukemia (APL)

within 10 days of treatment with ATRA at a dose of 40 mg orally twice daily

scrotal ulcer

development


Input: After initiation of topical vitamin D3 ointment (20 micro g/g of tacalcitol) 10 g/day for the skin lesions, both the serum level of calcium and urinary excretion of calcium increased gradually.

serum level of calcium and urinary excretion of calcium increased

After initiation of topical vitamin D3 ointment (20 micro g/g of tacalcitol) 10 g/day

increased


Input: Vancomycin is the most frequently implicated drug, but other agents have been reported to cause LABD.

LABD

Vancomycin

cause


Input: Vision declined after treatment with methylprednisolone, after which fundus examination became consistent with progressive outer retinal necrosis.

Vision declined

methylprednisolone

after


Input: Eight days after the end of interferon treatment, he showed signs of inability to sit still for ten seconds and walked around constantly.

signs of inability to sit still for ten seconds and walked around constantly

he

Eight days after the end of interferon treatment

inability


Input: Drug-induced agranulocytosis during treatment with infliximab in enteropathic spondyloarthropathy.

Drug-induced agranulocytosis

infliximab

during


Input: Aripiprazole-induced hiccups: a case report.

Aripiprazole

hiccups

induced


Input: The hepatic enzyme disturbances normalized after discontinuation of pegvisomant.

pegvisomant

The hepatic enzyme disturbances

after


Input: We present a case of a 58-year-old female patient with Graves' disease who developed AA in the third exposure to methimazole (MMI).

a 58-year-old female patient with Graves' disease

AA

in the third exposure to methimazole (MMI)

developed


Input: CONCLUSIONS: This is the second case report that describes gemcitabine-induced radiation recall in rectus abdominus muscles after gemcitabine-based radiation therapy.

gemcitabine

radiation recall in rectus abdominus muscles

induced


Input: One patient was an 80-year-old woman who was admitted for Staphylococcus aureus knee arthritis after several intraarticular injections of sodium hyaluronate and corticosteroids.

an 80-year-old woman

Staphylococcus aureus knee arthritis

sodium hyaluronate and corticosteroids

after


Input: Association of zomepirac administration with renal cortical necrosis is not known to have been previously demonstrated.

zomepirac

renal cortical necrosis

Association


Input: Vasomotor reactions after gold sodium thiomalate are well recognized.

Vasomotor reactions

gold sodium thiomalate

after


Input: Moxifloxacin-acetaminophen-warfarin interaction during bacille Calmette-Guerin treatment for bladder cancer.

Moxifloxacin-acetaminophen-warfarin interaction

bacille Calmette-Guerin treatment

during


Input: In four patients, thrombosis occurred 2-45 days after severe hepatic veno-occlusive disease (HVOD) secondary to intensive chemotherapy containing busulfan.

four patients

thrombosis occurred

severe hepatic veno-occlusive disease (HVOD)

intensive chemotherapy containing busulfan

secondary


Input: An adolescent male developed acute pancreatitis and pseudocyst of the pancreas 16 weeks after cessation of intramuscular L-asparaginase.

cessation of intramuscular L-asparaginase

An adolescent male

acute pancreatitis and pseudocyst of the pancreas

after


Input: A CFTR potentiator in patients with cystic fibrosis and the G551D mutation.

CFTR potentiator

patients with cystic fibrosis and the G551D mutation

in


Input: Quinapril is an angiotensin-converting enzyme inhibitor (ACE-inhibitor) and overdose can lead to prolonged hypotension and, less frequently, transient renal impairment.

Quinapril

prolonged hypotension and, less frequently, transient renal impairment

can lead to


Input: We describe a renal transplant recipient maintained on cyclosporine and prednisone developing Nocardia Asteroides brain abscess.

a renal transplant recipient

maintained on cyclosporine and prednisone

Nocardia Asteroides brain abscess

developing


Input: After an extensive review of the literature, we believe that this is the first communication of the successful use of amiodarone to control hyperthyroidism in a patient with PTU-induced fulminant hepatitis.

amiodarone

a patient with PTU-induced fulminant hepatitis

control

PTU

fulminant hepatitis

induced


Input: After identification of the index patient, additional inquiry revealed that the patient's mother was hospitalized previously for overwhelming sepsis associated with metamizole use.

the patient's mother

overwhelming sepsis

metamizole

overwhelming

associated


Input: We report here on a heretofore undescribed respiratory syncytial virus (RSV) infection in a patient with a long-standing history of refractory CLL that was treated with fludarabine phosphate.

respiratory syncytial virus (RSV) infection

a patient with a long-standing history of refractory CLL

fludarabine phosphate

treated


Input: A 77-year-old woman with no history of epilepsy presented a probable nonconvulsive status epilepticus while receiving continuous intravenous morphine for back pain relating to vertebral metastasis of a malignant lymphoma.

A 77-year-old woman with no history of epilepsy

continuous intravenous morphine

a probable nonconvulsive status epilepticus

receiving


Input: Oral corticosteroids (OCS) may be associated with systemic adverse events (AEs), which can be reduced by replacing OCS with inhaled corticosteroids (ICS).

systemic adverse events (AEs)

Oral corticosteroids (OCS)

may

associated


Input: Development of Peyronie's disease during long-term colchicine treatment.

Peyronie's disease

long-term colchicine treatment

during


Input: The principle treatment for DPD-deficient patients with severe acute 5-FU reactions is supportive care; however, the administration of thymidine potentially may reverse severe 5-FU-induced neurologic symptoms such as encephalopathy and coma.

thymidine

DPD-deficient patients with severe acute 5-FU reactions

reverse

neurologic symptoms such as encephalopathy and coma

induced


Input: Adverse reaction in a patient with aspirin-induced asthma treated with zafirlukast.

a patient

aspirin

asthma

induced


Input: The nephrotic syndrome developed in a patient receiving therapy with gold for rheumatoid arthritis.

nephrotic syndrome

a patient

therapy with gold

developed


Input: This observation adds another dimension to the previously reported renal complications of nonsteroidal anti-inflammatory agents, especially zomepirac.

nonsteroidal anti-inflammatory agents, especially zomepirac

renal complications

reported


Input: Clinical, spectroscopic, and imaging abnormalities resolved with discontinuation of metronidazole.

Clinical, spectroscopic, and imaging abnormalities

metronidazole

resolved


Input: In two other patients (one after OLTX and one with Crohn's disease), a raltegravir-based HIV therapy was started while patients received 1 or 2 mg of tacrolimus twice daily.

two other patients (one after OLTX and one with Crohn's disease)

raltegravir

1 or 2 mg of tacrolimus twice daily.

received


Input: Reversible cardiomyopathy caused by administration of interferon alpha.

Reversible cardiomyopathy

administration of interferon alpha

caused by


Input: Metipranolol associated granulomatous anterior uveitis: not so uncommon as thought.

Metipranolol

granulomatous anterior uveitis

associated


Input: There was an increase in serious adverse events with bleeding in the tifacogin group in both cohorts (6.5% tifacogin and 4.8% placebo for high INR; 6.0% tifacogin and 3.3% placebo for low INR).

bleeding

tifacogin

adverse events


Input: We also describe a case of timolol-induced ocular pemphigoid.

timolol

ocular pemphigoid

a case

induced


Input: A 70-year-old man was admitted to our hospital because of dyspnea after taking an antihistaminic agent (homochlorcyclizine hydrochloride) for itching.

A 70-year-old man

an antihistaminic agent (homochlorcyclizine hydrochloride)

dyspnea

taking


Input: Methadone withdrawal when starting an antiretroviral regimen including nevirapine.

an antiretroviral regimen including nevirapine

Methadone withdrawal

starting


Input: The oligohidrosis caused by zonisamide was reversible in that the patient regained the ability to sweat within 2 weeks of the cessation of drug administration.

the patient

zonisamide

cessation of drug administration

regained the ability to sweat within 2 weeks

of the


Input: Radiation recall related to gemcitabine has been reported in lung and breast cancer.

Radiation recall

gemcitabine

related


Input: It carries a well-known risk of neutropenia and agranulocytosis, which necessitates the immediate discontinuation of clozapine.

neutropenia and agranulocytosis

clozapine

immediate discontinuation

risk


Input: Vicriviroc (SCH 417690), a CCR5 receptor antagonist, is currently under investigation for the treatment of human immunodeficiency virus infection.

Vicriviroc (SCH 417690), a CCR5 receptor antagonist

treatment


Input: Children receiving zonisamide should be monitored for oligohidrosis and the development of neurological symptoms associated with an elevation of body temperature.

Children

zonisamide

oligohidrosis

development of neurological symptoms associated

monitored


Input: This concerns 2 male patients who experienced incontinence while taking venlafaxine.

2 male patients

incontinence

venlafaxine

experienced


Input: Polyarthritis, hepatitis and anti-native DNA antibodies after treatment with ethambutol and rifampicin.

Polyarthritis, hepatitis and anti-native DNA antibodies

ethambutol and rifampicin

after


Input: We report an HIV-infected woman who developed mild leukopenia as the first sign of a nevirapine-related adverse event, which was followed by skin and hepatic toxicity associated with a more severe leukopenia.

mild leukopenia

followed by skin and hepatic toxicity associated with a more severe leukopeni

HIV-infected woman

nevirapine

mild

developed


Input: OBJECTIVE: To report a case of rapidly occurring hyperglycemia that occurred in a geriatric patient 3 days after treatment with olanzapine.

hyperglycemia

a geriatric patient

olanzapine

occurring


Input: Tifacogin administration was associated with an increase in risk of bleeding, irrespective of baseline INR.

Tifacogin

an increase in risk of bleeding

associated


Input: Gynecomastia developed in two epileptic patients some months after the addition of oral fluoresone 750 mg daily to the phenobarbital and phenytoin already being administered.

Gynecomastia

two epileptic patients

some months after the addition of oral fluoresone 750 mg daily to the phenobarbital and phenytoin already being administered

developed


Input: The authors describe a case of combined lithium and haloperidol toxicity characterized by hyperpyrexia, severe rigidity, mutism, and development of irreversible tardive dyskinesia.

combined lithium and haloperidol

hyperpyrexia, severe rigidity, mutism, and development of irreversible tardive dyskinesia

toxicity


Input: Occasionally, despite good therapeutic response, clozapine must be stopped due to dangerous side effects such as agranulocytosis.

clozapine

dangerous side effects such as agranulocytosis

due to


Input: Three cases of pseudocyst of the pancreas in two women and one man have previously been reported with the use of intravenous L-asparaginase.

pseudocyst of the pancreas

two women and one man

intravenous L-asparaginase

reported


Input: We report a case of Ritalin-associated cataract and glaucoma.

Ritalin

cataract and glaucoma

associated


Input: We discuss a patient who developed severe renal tubular dysfunction secondary to short-term therapy with Amikacin, resulting in refractory hypokalemia, hypocalcemia, hypomagnesemia, metabolic alkalosis, and polyuria.

severe renal tubular dysfunction

resulting in refractory hypokalemia, hypocalcemia, hypomagnesemia, metabolic alkalosis, and polyuria

short-term therapy with Amikacin

developed