Input: Cardiac toxicity related to BCNU has not been described well.

Cardiac toxicity

BCNU

related


Input: Aprepitant is a neurokinin(1) receptor antagonist that enhances prevention of chemotherapy-induced nausea and vomiting when added to conventional therapy with a corticosteroid and a 5-hydroxytryptamine(3) (5-HT(3)) antagonist.

Aprepitant

added to conventional therapy with a corticosteroid and a 5-hydroxytryptamine(3) (5-HT(3)) antagonist

prevention of chemotherapy-induced nausea and vomiting

enhances


Input: Thus, tacrolimus-induced HUS is a rare cause of ARF in nephrotic syndrome.

tacrolimus

HUS

induced


Input: Clinicians should be vigilant when monitoring for cardiotoxicity in patients receiving pentamidine throughout the duration of therapy.

cardiotoxicity

patients

pentamidine

receiving


Input: The present case is the first report of hypercalcemia induced by vitamin D3 ointment and thiazide simultaneously.

hypercalcemia

vitamin D3 ointment and thiazide simultaneously

The present case

induced


Input: CONCLUSION: Significant weight loss is a potential adverse event in patients with rheumatoid arthritis treated with leflunomide.

Significant weight loss

leflunomide

potential adverse even


Input: We have described a man with classic rheumatoid arthritis who had membranous nephropathy associated with nephrotic syndrome not related to gold or penicillamine therapy.

a man with classic rheumatoid arthritis

membranous nephropathy associated with nephrotic syndrome

gold or penicillamine therapy

not

not related


Input: Pharmacokinetics of etravirine in HIV-infected patients concomitantly treated with rifampin for tuberculosis.

HIV-infected patients

Pharmacokinetics of etravirine

concomitantly treated with rifampin

for


Input: We thus concluded that an excessive dose of AZ had probably destroyed the gastric mucosal barrier or thrombocytopenia due to bone marrow disorder and thus eventually led to the development of hemorrhagic gastritis.

excessive dose of AZ

destroyed the gastric mucosal barrier or thrombocytopenia

hemorrhagic gastritis

probably

had


Input: Acyclovir-induced neurotoxicity: concentration-side effect relationship in acyclovir overdose.

Acyclovir

neurotoxicity

induced


Input: Psoriasis-like skin reaction in a patient with rheumatoid arthritis after sulphasalazine therapy.

a patient with rheumatoid arthritis

Psoriasis-like skin reaction

sulphasalazine therapy

after


Input: We describe the clinical course of 2 patients with Crohn's disease (CD) in whom lymphoma was diagnosed after treatment with infliximab.

treatment with infliximab

2 patients with Crohn's disease (CD)

lymphoma

diagnosed


Input: Valproic acid is commonly and effectively used in the treatment of idiopathic generalized epilepsies, including juvenile absence epilepsy.

Valproic acid

commonly

used


Input: We report a case of intrathecal methotrexate neurotoxicity manifesting as left arm weakness and aphasia.

left arm weakness and aphasia

intrathecal methotrexate neurotoxicity

a case

manifesting


Input: According to the Drug Interaction Probability Scale, a causal relationship between the warfarin-cloxacillin interaction and increased INR value was rated "probable".

warfarin

cloxacillin

increased INR value

probable

relationship


Input: We present the cases of two female patients diagnosed with relapsing-remitting multiple sclerosis (RRMS) who developed inflammatory musculoskeletal manifestations, following IFN-beta therapy.

two female patients diagnosed with relapsing-remitting multiple sclerosis (RRMS)

inflammatory musculoskeletal manifestations

IFN-beta

developed


Input: Dystonia associated with carbamazepine administration: experience in brain-damaged children.

Dystonia

carbamazepine administration

brain-damaged children

associated with


Input: In all, 51 patients had a gastrointestinal event; the event rate was 1.1% with omeprazole and 2.9% with placebo at 180 days (hazard ratio with omeprazole, 0.34, 95% confidence interval [CI], 0.18 to 0.63; P<0.001).

gastrointestinal event

51 patients

1.1% with omeprazole and 2.9% with placebo

had


Input: CONCLUSION: We report a case of the use of pamidronate for significant hypercalcemia secondary to acute vitamin D poisoning.

pamidronate

a case

for


Input: Clopidogrel with or without omeprazole in coronary artery disease.

Clopidogrel with or without omeprazole

in


Input: The cases are important in documenting that drug-induced dystonias do occur in patients with dementia, that risperidone appears to have contributed to dystonia among elderly patients, and that the categorization of dystonic reactions needs further clarification.

patients with dementia

elderly patients

dystonia

risperidone

appears

contributed


Input: In addition, there is a report on prolonged ECT seizure related to ciprofloxacin, which has an epileptogenic property with a similar action to beta-lactam antibiotics.

prolonged ECT seizure

ciprofloxacin

related


Input: After abstinence from oolong tea his delirium resolved.

oolong tea

After


Input: Anaphylaxis to intrathecal diamorphine.

Anaphylaxis

intrathecal diamorphine

to


Input: This case suggests that acyclovir when given intravenously in doses of 10 mg/kg may result in increased serum lithium concentrations.

acyclovir

increased serum lithium concentrations

may

result


Input: After approximately two weeks of sertraline treatment he noted an intense itching sensation in his scalp after eating a piece of chocolate cake.

two weeks of sertraline

ntense itching sensation in his scalp

intense

noted


Input: Pigmentary aberrations are well known side effects of cytostatic chemotherapeutic agents.

Pigmentary aberrations

cytostatic chemotherapeutic agents

side effects


Input: CONCLUSION: Atovaquone should be added to the list of agents causing vortex keratopathy involving the corneal epithelium.

Atovaquone

vortex keratopathy involving the corneal epithelium

causing


Input: A generalized tonic-clonic seizure occurred a few minutes after injection of the morphine antagonist naloxone.

a few minutes after injection of the morphine antagonist naloxone

generalized tonic-clonic seizure

occurred


Input: CONCLUSION: Squamous metaplasia in these cases appears to be a consequence of progestin therapy.

Squamous metaplasia

progestin therapy

these cases

appears to be

consequence


Input: This association should be considered in the period after vasopressin-treated gastrointestinal hemorrhage.

vasopressin

gastrointestinal hemorrhage

after


Input: The gynecomastia regressed when the theophylline was discontinued.

theophylline

gynecomastia

discontinued


Input: Renal hypophosphatemia in this patient was caused by the erroneous intake of 1 g doxycycline.

the erroneous intake of 1 g doxycycline.

this patient

Renal hypophosphatemia

caused


Input: Despite a response of the meningeal tumor the patient developed in the third week of MTX treatment a progressive visual loss and loss of consciousness which worsened during subsequent Ara-C treatment and led to death within 3 weeks.

MTX treatment

subsequent Ara-C treatment

within 3 weeks.

the patient

a progressive visual loss and loss of consciousness

led to death

developed


Input: After seven months' continuous treatment for suspected tuberculosis with rifampicin and ethambutol a nine-year-old boy developed polyarthritis, rash and hepatitis in association with anti-native DNA antibodies and positive antinuclear factor.

seven months' continuous treatment

with rifampicin and ethambutol

a nine-year-old boy

polyarthritis, rash and hepatitis in association with anti-native DNA antibodies and positive antinuclear factor

developed


Input: A few recent individual case reports have suggested that a myasthenic syndrome may be associated with statin treatment, but this association is not well described.

myasthenic syndrome

statin treatment

A few recent individual case

associated


Input: Topical imiquimod and tumor necrosis factor (TNF)-alpha inhibitors have gained wide acceptance as safe and effective treatments for non-melanoma skin cancer (NMSC) and moderate to severe psoriasis, respectively.

Topical imiquimod

treatments

tumor necrosis factor (TNF)-alpha

treatments


Input: Focal renal cortical necrosis associated with zomepirac.

Focal renal cortical necrosis

zomepirac

associated


Input: We experienced 2 cases of mequitazine-induced photosensitivity reaction in patients who took mequitazine for their dermatologic problems.

photosensitivity reaction

patients

mequitazine

induced


Input: Carboplatin was substituted for cisplatin, and there were no further episodes of SIADH.

Carboplatin was substituted for cisplatin

no further

substituted


Input: Severe steroid-induced glaucoma following intravitreal injection of triamcinolone acetonide.

intravitreal injection of triamcinolone acetonide

glaucoma

Severe

induced


Input: CD20-negative T-cell-rich B-cell lymphoma as a progression of a nodular lymphocyte-predominant Hodgkin's lymphoma treated with rituximab: a molecular analysis using laser capture microdissection.

rituximab

CD20-negative T-cell-rich B-cell lymphoma

treated


Input: We report the case of an adult patient with acute lymphoblastic leukemia who presented with repeated transient ischemic attacks followed by a seizure during consolidation treatment with L-asparaginase.

an adult patient with acute lymphoblastic leukemia

consolidation treatment with L-asparaginase

repeated transient ischemic attacks followed by a seizure

presented


Input: Gemcitabine-related radiation recall in a patient with pancreatic cancer.

Gemcitabine

radiation recall

a patient with pancreatic cancer

related


Input: After development of the tics in 2, CBZ was continued at the same or higher dose, and the tics abated and then ceased spontaneously < or = 6 months.

tics

CBZ

development


Input: Thus any case of severe neutropenia occurring in a patient receiving olanzapine is alarming to clinicians.

severe neutropenia

a patient

olanzapine

severe

occurring


Input: We describe 3 AS patients treated with etanercept for active AS who developed new onset of CD while AS related symptoms responded well to etanercept.

3 AS patients

CD

etanercept for active AS

developed


Input: It is concluded that the aforementioned pathological manifestations were due to chemotherapy and included a pulmonary adverse reaction, a feature never previously associated with oxaliplatinum and 5-fluorouracil regimens.

a pulmonary adverse reaction

oxaliplatinum and 5-fluorouracil regimens

associated


Input: A case of colchicine-induced rhabdomyolysis is reported.

colchicine

rhabdomyolysis

induced


Input: Because of a recurrence of paroxysmal atrial fibrillation, the dose of the drug was increased to 1.4 g/day; 24 hours later AVT with syncope developed but responded promptly to atropine.

paroxysmal atrial fibrillation

the dose of the drug was increased to 1.4 g/day

AVT with syncope

developed

atropine

responded


Input: Three male patients aged 78-83 years are presented, in whom severe hepatotoxic reactions emerged after CPA administration.

CPA

severe hepatotoxic reactions

Three male patients aged 78-83 years

severe

after


Input: Exacerbations of the heart failure were temporally related to the administration of the antitumor antibiotics actinomycin-D (NSC-3053) and mithramycin (NSC-24559).

Exacerbations of the heart failure

antitumor antibiotics actinomycin-D (NSC-3053) and mithramycin (NSC-24559)

related


Input: Diffuse alveolar hemorrhage after leflunomide therapy in a patient with rheumatoid arthritis.

Diffuse alveolar hemorrhage

a patient with rheumatoid arthritis

leflunomide

after


Input: We report a case of a 64-year-old man with secondary adrenocortical insufficiency who has been on a chronic transdermal fentanyl treatment because of sciatic pain syndrome.

a 64-year-old man

secondary adrenocortical insufficiency

a chronic transdermal fentanyl treatment

with


Input: A 52-year-old, white female developed low-grade fever, cough, and dyspnea after 8 weeks treatment with sodium aurothiomalate for rheumatoid arthritis.

A 52-year-old

white female

low-grade fever, cough, and dyspnea

sodium aurothiomalate

developed


Input: In both cases, high fever, skin rash, liver dysfunction and atypical lymphocytosis developed 3 weeks after initiating treatment with SASP.

high fever, skin rash, liver dysfunction and atypical lymphocytosis

SASP

In both cases

developed


Input: OBJECTIVE: To report a case of severe chloroquine toxicity in the presence of high-grade chloroquine-resistant Plasmodium vivax.

severe chloroquine toxicity

high-grade chloroquine-resistant Plasmodium vivax

chloroquine

severe

toxicity


Input: RESULTS: All cases developed corneal endothelial deposits after previous use of rifabutin.

All cases

corneal endothelial deposits

rifabutin

developed


Input: Two infants developed hyperkalemia shortly after cessation of prolonged ACTH therapy for infantile spasms.

Two infants

hyperkalemia

shortly after cessation of prolonged ACTH therapy

developed


Input: In this case, CIPS was considered to be probably associated with cyclosporine according to the Naranjo probability scale.

cyclosporine

CIPS

probably

associated


Input: Acute syphilitic posterior placoid chorioretinitis following intravitreal triamcinolone acetonide injection.

Acute syphilitic posterior placoid chorioretinitis

intravitreal triamcinolone acetonide injection

following


Input: Delayed pseudocyst of the pancreas can be a complication of intramuscular L-asparaginase.

intramuscular L-asparaginase

Delayed pseudocyst of the pancreas

can

can


Input: I report a 35-year-old woman with occult coronary artery disease who experienced cardiac arrest within minutes after receiving a first-time dose of subcutaneous sumatriptan for migraine.

a 35-year-old woman with occult coronary artery disease

cardiac arrest

within minutes after receiving a first-time dose of subcutaneous sumatriptan

experienced


Input: Epoprostenol (prostacyclin) is currently approved for treatment of primary pulmonary hypertension; however, it is being evaluated in other forms of pulmonary hypertension, particularly scleroderma.

Epoprostenol (prostacyclin)

treatment


Input: OBJECTIVE: To report a fatal case of toxic epidermal necrolysis in a man who was treated with oral ofloxacin for epididymitis.

fatal case of toxic epidermal necrolysis

man

oral ofloxacin

fatal

treated


Input: Massive pulmonary embolism due to late-onset heparin-induced thrombocytopenia following coronary artery bypass graft surgery: successful treatment with lepirudin.

Massive pulmonary embolism

heparin

due


Input: Value of high-dose cytarabine during interval therapy of a Berlin-Frankfurt-Munster-based protocol in increased-risk children with acute lymphoblastic leukemia and lymphoblastic lymphoma: results of the European Organization for Research and Treatment of Cancer 58881 randomized phase III trial.

high-dose cytarabine during interval therapy of a Berlin-Frankfurt-Munster-based protocol

increased-risk children with acute lymphoblastic leukemia and lymphoblastic lymphoma

risk

Value


Input: We report a case of fulminant hepatic failure associated with didanosine and masquerading as a surgical abdomen and compare the clinical, biologic, histologic, and ultrastructural findings with reports described previously.

a case

fulminant hepatic failure

didanosine

associated


Input: An objective causal assessment suggests that rhabdomyolysis, renal failure, and possibly hepatotoxicity were probably related to an amiodarone-simvastatin interaction.

rhabdomyolysis, renal failure, and possibly hepatotoxicity

an amiodarone-simvastatin interaction

probably

related


Input: Nail staining from hydroquinone cream.

hydroquinone cream

Nail staining

from


Input: The development of an IgG lambda-type monoclonal gammopathy and subsequent multiple myeloma in an epilepsy patient on diphenylhydantoin (DILANTIN) therapy for 20 years is reported.

an epilepsy patient

diphenylhydantoin (DILANTIN) therapy for 20 years

an IgG lambda-type monoclonal gammopathy and subsequent multiple myeloma

development


Input: Ibuprofen overdose is usually characterized by GI upset, dizziness, and mild sedation.

Ibuprofen overdose

GI upset, dizziness, and mild sedation

characterized


Input: His PD medications (pramipexole, entacapone, and immediate-release levodopa/carbidopa 100 mg/25 mg, 1.5 tablets 4 times daily) were administered via nasogastric tube.

His PD

pramipexole, entacapone, and immediate-release levodopa/carbidopa 100 mg/25 mg, 1.5 tablets 4 times daily

via nasogastric tube

administered


Input: CONCLUSIONS: This is the first report of a possible interaction between propafenone and citalopram, which caused propafenone adverse effects (eg, dizziness, falls) and mimicked coronary artery disease.

propafenone

citalopram

adverse effects (eg, dizziness, falls) and mimicked coronary artery disease

caused


Input: We report the case of a young healthy woman who presented an early overanticoagulation when receiving acenocoumarol for a first thromboembolic episode.

a young healthy woman

early overanticoagulation

acenocoumarol

presented


Input: A patient with acute changes suggesting acute hepatitis after parenteral amiodarone administration is described.

parenteral amiodarone administration

acute changes suggesting acute hepatitis

A patient

after


Input: Subsequently, he developed hyperglycemia (fasting blood glucose 138 mg/dL) that resolved when olanzapine was stopped and recurred (fasting blood glucose 150 mg/dL) after 2 days of rechallenge with olanzapine 2.5 mg twice daily.

olanzapine was stopped

resolved

hyperglycemia

recurred (fasting blood glucose 150 mg/dL)

2 days of rechallenge with olanzapine 2.5 mg twice daily

after


Input: Fulminant hepatitis with severe lactate acidosis in HIV-infected patients on didanosine therapy.

Fulminant hepatitis with severe lactate acidosis

didanosine

HIV-infected patients

on


Input: Persisent ocular hypertension following intravitreal ranibizumab.

Persisent ocular hypertension

intravitreal ranibizumab

following


Input: STUDY DESIGN: Case report of a 31-year-old woman who presented with toxic myelopathy due to intrathecal administration of doxorubicin.

intrathecal administration of doxorubicin.

toxic myelopathy

a 31-year-old woman

due


Input: The patient had a background of obsessive compulsive disorder treated with paroxetine.

paroxetine

The patient had a background of obsessive compulsive disorder

treated


Input: Clozapine is speculated to cause rhabdomyolysis in patients with defective calcium-activated K+ channels.

Clozapine

rhabdomyolysis

patients with defective calcium-activated K+ channels

speculated

cause


Input: CONCLUSIONS: We report the first case of gemcitabine-induced LABD.

gemcitabine

LABD

induced


Input: Nitrofurantoin-induced lung disease: two cases demonstrating resolution of apparently irreversible CT abnormalities.

Nitrofurantoin

lung disease

induced


Input: Trazodone-induced transient hypomanic symptoms and their management.

Trazodone

transient hypomanic symptoms

induced


Input: Acute aluminum toxicity after continuous intravesical alum irrigation for hemorrhagic cystitis.

Acute aluminum toxicity

continuous intravesical alum irrigation

after


Input: Amphotericin B-induced cutaneous leucocytoclastic vasculitis: case report.

Amphotericin B

cutaneous leucocytoclastic vasculitis

induced


Input: When measured, the serum lithium level had increased 4-fold during acyclovir therapy.

serum lithium level had increased 4-fold

acyclovir

during


Input: In this paper it is reported an evidence of pharmacokinetic interaction between clarithromycin and sirolimus in a kidney transplanted woman, suffering from pulmonary infection sustained by a bacterial pathogen, in particular Hemophilus Influenzae.

clarithromycin and sirolimus

a kidney transplanted woman, suffering from pulmonary infection sustained by a bacterial pathogen, in particular Hemophilus Influenzae

pharmacokinetic interaction

between


Input: A 25-year-old man with a history of mid-borderline (BB) Hansen's disease developing a reversal reaction after starting dapsone and rifampin therapy is presented.

dapsone and rifampin therapy

A 25-year-old man with a history of mid-borderline (BB) Hansen's disease

a reversal reaction

after


Input: In all cases, drugs in addition to quetiapine were detected, but in cases #1 and #2, the cause of death was considered to be a quetiapine overdose and the other drugs were not considered to be contributory.

cases #1 and #2

quetiapine overdose

death

death

cause


Input: Similar to antiarrhythmic drugs aggravating particular arrhythmias, antiepileptic drugs can paradoxically induce new seizure types or exacerbate existing ones.

antiepileptic drugs

new seizure types or exacerbate existing ones

induce


Input: We report here a rare case of ritodrine-hydrochloride-induced rhabdomyolysis in a pregnant patient with myotonic dystrophy.

ritodrine-hydrochloride

rhabdomyolysis

pregnant patient with myotonic dystrophy.

induced


Input: OBJECTIVE: To report the finding of squamous metaplasia within endometrial glands occurring as a result of progestin therapy of hyperplasia.

squamous metaplasia within endometrial glands

progestin therapy

as a result of


Input: IMPLICATIONS FOR NURSING PRACTICE: Nurses must understand the pharmacology, mechanism of action, clinical presentation, potentially lethal risks, and traumatic psychosocial stresses experienced by DPD-deficient patients with cancer receiving 5-FU therapy in order to develop timely interventions and alternative plans of care.

5-FU therapy

DPD-deficient patients with cancer

receiving


Input: Methotrexate is an effective but potentially toxic treatment for psoriasis.

Methotrexate

treatment


Input: Typical symptoms of active CD occurred 11, 12, and 26 months after start of etanercept therapy, respectively.

Typical symptoms of active CD

etanercept therapy

occurred


Input: This progressed to tracheal compression with stridor after he had taken some aspirin for relief of the neck pain.

tracheal compression with stridor

aspirin

he

progressed


Input: OBJECTIVE: To report a case of toxin-positive Clostridium difficile-induced colitis (CDIC) after use of clindamycin phosphate vaginal cream.

toxin-positive Clostridium difficile-induced colitis

clindamycin phosphate vaginal cream

after


Input: Severe vancomycin-induced anaphylactic reaction.

vancomycin

anaphylactic reaction

Severe

induced


Input: We report the case of a 74-year-old female patient who received the antide-pressant amitriptyline because of a major depression.

a 74-year-old female patient

a major depression

antide-pressant amitriptyline

received


Input: Rhabdomyolysis has been recognized as a complication of tocolytic therapy with ritodrine hydrochloride.

Rhabdomyolysis

ritodrine hydrochloride

complication


Input: Voriconazole (VRC) has not previously been reported to cause angio-oedema.

Voriconazole (VRC)

angio-oedema

not

cause


Input: CONCLUSION: Tamoxifen may cause malignant transformation of endometriosis through atypical endometriosis even in the postmenopausal state.

Tamoxifen

malignant transformation of endometriosis through atypical endometriosis

cause


Input: One patient had an episode of prostatitis, which was treated with levofloxacin immediately prior to tolterodine initiation.

levofloxacin

tolterodine

One patient

treated


Input: The first patient developed a monoarthritis 2 weeks after initiation of IFN-beta, which persisted during the 14 months of therapy and resolved with discontinuation of the medication.

The first patient

IFN-beta

monoarthritis

initiation


Input: The present report illustrates a rare case of refractory akathisia after interferon-alpha treatment and also that levodopa treatment would be theoretically and practically useful in reducing the neurotoxicity associated with interferon-alpha.

refractory akathisia

interferon-alpha treatment

after

neurotoxicity

interferon-alpha

associated

levodopa treatment

useful


Input: Rosaceiform eruption induced by erlotinib.

Rosaceiform eruption

erlotinib.

induced


Input: The incidence of oral-verapamil-induced hypotension in the presence of concomitant beta-adrenergic blockade by the oral route is quite rare.

oral-verapamil

in the presence of concomitant beta-adrenergic blockade

hypotension

induced


Input: Until additional data are available, if intravenous acyclovir is administered concurrently with lithium, we recommend closely monitoring patients for signs of lithium toxicity and measuring serum lithium levels every second or third day.

intravenous acyclovir is administered concurrently with lithium

lithium toxicity

signs


Input: Disappointingly, with the dose schedule used in this protocol, HD Ara-C added to HD MTX, although well tolerated, failed to further decrease the incidence of CNS relapse or to improve the overall DFS.

HD Ara-C

HD MTX

further decrease the incidence of CNS relapse or to improve the overall DFS

failed


Input: Theophylline intoxication following viloxazine induced decrease in clearance.

Theophylline intoxication

viloxazine

following


Input: Cercarial encystment at concentrations of 25000 microg/l or higher was significantly impaired by all test metals; however, at lower concentrations only zinc demonstrated toxicity.

lower concentrations

zinc

toxicity

demonstrated


Input: PURPOSE: We report an unusual paradoxical effect of brimonidine.

unusual paradoxical effect

brimonidine

of


Input: Renal failure after high-dose methotrexate in a child homozygous for MTHFR C677T polymorphism.

Renal failure

high-dose methotrexate

a child homozygous for MTHFR C677T polymorphism

after


Input: Although his renal function recovered completely with high-dose leucovorin, hemodialysis, charcoal hemoperfusion, and carboxypeptidase G2, we present this case to emphasize that signs of renal toxicity may be present as early as 2 hours after the completion of a 4-hour MTX infusion, and to suggest that monitoring for MTX toxicity should perhaps begin within a few hours after the completion of 4-hour MTX infusion.

renal toxicity

2 hours after the completion of a 4-hour MTX infusion

after

high-dose leucovorin, hemodialysis, charcoal hemoperfusion, and carboxypeptidase G2

recovered


Input: Ten to 15% of patients treated with ifosfamide develop an encephalopathy.

Ten to 15% of patients

ifosfamide

encephalopathy.

develop


Input: METHODS: We queried 35 rheumatologists at the Robert Breck Brigham Arthritis Center to determine if weight loss had occurred as an adverse event in patients treated with leflunomide between November 1998 and January 2000.

weight loss

patients

leflunomide

queried

occurred


Input: This is the first report of a catatonic syndrome occurring in a patient receiving disulfiram treatment.

catatonic syndrome

disulfiram treatment

occurring


Input: Management of hypophosphatemia induced by high-flux hemodiafiltration for the treatment of vancomycin toxicity: intravenous phosphorus therapy versus use of a phosphorus-enriched dialysate.

intravenous phosphorus

phosphorus-enriched dialysate

Management


Input: Two weeks following rechallenge with alendronate sodium resulted in recurrence of his scleritis.

scleritis

alendronate sodium

Two weeks following

resulted


Input: We believe this is the first report of intrathecal diamorphine causing anaphylaxis.

intrathecal diamorphine

anaphylaxis

causing


Input: Clearance rates of cerivastatin metabolites in a patient with cerivastatin-induced rhabdomyolysis.

rhabdomyolysis

cerivastatin

induced


Input: This case report and several others point toward azathioprine as a clinically significant inducer of warfarin resistance.

azathioprine

warfarin resistance

inducer


Input: PURPOSE: To report a case of nodular scleritis following alendronate sodium.

nodular scleritis

alendronate sodium

following


Input: Most cardiac surgical patients have had previous exposure to heparin for diagnostic or therapeutic interventions and hence have an increased susceptibility to developing heparin-induced thrombocytopenia (HIT) postoperatively.

Most cardiac surgical patients

heparin

heparin-induced thrombocytopenia (HIT)

developing


Input: PURPOSE: We studied a case of vortex keratopathy that was associated with the use of atovaquone.

a case

vortex keratopathy

atovaquone

associated


Input: While on a maximal dose of phenylephrine she developed prominent positive U waves, which disappeared with the cessation of the drug.

maximal dose of phenylephrine

positive U waves

she

developed


Input: RESULTS: Two patients with ocular inflammation of unknown origin developed severe chorioretinitis after IVTA injection.

Two patients with ocular inflammation

IVTA injection

severe chorioretinitis

severe

developed


Input: Disopyramide was started on admission for supraventricular tachycardia.

Disopyramide

started


Input: A 50-year-old woman with a history of migraine without aura, predominantly occurring around her menstrual periods, developed a spinal cord lesion following the use of zolmitriptan.

zolmitriptan

a spinal cord lesion

A 50-year-old woman with a history of migraine without aura, predominantly occurring around her menstrual periods

developed


Input: The skin rash effect was most probably due, in first line, to olanzapine, but the cutaneous skin condition was triggered and aggravated by pravastatin, a 3-hydoxy-3-methylglutaryl-coenzyme A-(HMG-CoA)-reductase inhibitor, and lithium medication.

skin rash effect

cutaneous skin condition

olanzapine,

by pravastatin, a 3-hydoxy-3-methylglutaryl-coenzyme A-(HMG-CoA)-reductase inhibitor, and lithium

probably

due


Input: CONCLUSION: Anterior ischemic optic neuropathy may complicate treatment with interferon alfa.

Anterior ischemic optic neuropathy

interferon alfa

complicate


Input: After 5 weeks of therapy, she stopped taking pantoprazole due to general malaise.

general malaise

taking pantoprazole

After 5 weeks of therapy

due to


Input: We report the use of pamidronate for acute, severe hypercalcemia secondary to iatrogenic vitamin D poisoning.

pamidronate

for

vitamin D

hypercalcemia

severe

secondary


Input: According to the Naranjo probability scale, the relationship of gemcitabine treatment with cutaneous eruption in our patient is possible.

cutaneous eruption

our patient

gemcitabine treatment

possible

with


Input: Methylene blue was administered to a 58-yr-old woman undergoing a parathyroidectomy under general anesthesia.

a 58-yr-old woman undergoing a parathyroidectomy under general anesthesia

Methylene blue

administered to


Input: We describe two cases that illustrate the use of lithium in the treatment of veterans with PTSD who complained of serious problems with irritability or angry outbursts.

lithium

veterans with PTSD

serious problems with irritability or angry outbursts

complained of


Input: It is well-recognized that flucloxacillin may occasionally result in fatal hepatic injury.

flucloxacillin

hepatic injury

may

fatal

result


Input: Neurologic toxicity associated with hepatic artery infusion HAI of FUdR.

Neurologic toxicity

hepatic artery infusion HAI of FUdR

associated with


Input: Hyperkalemia as a late side effect of prolonged adrenocorticotropic hormone therapy for infantile spasms.

Hyperkalemia

adrenocorticotropic hormone

infantile spasms

of


Input: METHODS: We report two cases of pseudoporphyria caused by naproxen and oxaprozin.

two cases

pseudoporphyria

naproxen and oxaprozin

caused


Input: She was treated with an average weekly warfarin dose of 39 mg (5.5 mg daily) prior to beginning azathioprine therapy.

She

average weekly warfarin dose of 39 mg (5.5 mg daily) prior to beginning azathioprine therapy

treated


Input: When the disease recurred conventional amphotericin B was used again, but had to be stopped because of severe side effects.

amphotericin B

side effects

severe

of


Input: Widespread cutaneous vasculitis associated with diltiazem.

diltiazem

cutaneous vasculitis

associated


Input: The following describes a patient on a stable regimen of warfarin who developed severe hypoprothrombinemia and bleeding 4 weeks after starting gemfibrozil.

a patient

on a stable regimen of warfarin

4 weeks after starting gemfibrozil

hypoprothrombinemia and bleeding

severe

developed


Input: We report the case of a 40-year-old woman who developed fulminant hepatic failure and aplastic anaemia following a course of oral flucloxacillin.

a 40-year-old woman

fulminant hepatic failure and aplastic anaemia

a course of oral flucloxacillin

developed


Input: This case highlights the possible development of acute coronary syndrome as a side effect of Capecitabine therapy.

Capecitabine

acute coronary syndrome

This case

possible

development


Input: These results indicate that lithium may cause biochemical hyperparathyroidism.

lithium

biochemical hyperparathyroidism

may


Input: The relationship between infliximab treatment and lymphoma in Crohn's disease.

lymphoma

infliximab

between


Input: CONCLUSION: There may be an association between raloxifene and the development of malignant mixed mesodermal tumor.

raloxifene

malignant mixed mesodermal tumor

may

association


Input: Early recognition of renal toxicity of high-dose methotrexate therapy: a case report.

renal toxicity

high-dose methotrexate therapy

recognition


Input: The mild immunosuppression that occurs with methotrexate therapy probably places patients with rheumatoid arthritis at added risk of developing lymphoproliferative diseases, but coincidence cannot be excluded.

methotrexate

mild immunosuppression

lymphoproliferative diseases

patients with rheumatoid arthritis

probably

developing


Input: We attribute the clinical and radiographic findings to cytotoxic edema secondary to intrathecal methotrexate.

intrathecal methotrexate

cytotoxic edema

attribute

attribute


Input: Morphine, an opium alkaloid, frequently causes side effects such as hyperhidrosis and facial flushing, but serious cutaneous adverse drug reactions are seldom observed.

Morphine

hyperhidrosis

facial flushing

causes


Input: Severe aphthous stomatitis associated with oral calcineurin and mTOR inhibitors.

Severe aphthous stomatitis

oral calcineurin and mTOR inhibitors

Severe

associated


Input: A 79-year-old man with ischemic heart disease, chronic atrial fibrillation, chronic renal failure, hypothyroidism, and gout arthritis was hospitalized because of fatigue, myalgia, and leg weakness, shortly after starting treatment with colchicine.

A 79-year-old man with ischemic heart disease, chronic atrial fibrillation, chronic renal failure, hypothyroidism, and gout arthritis

fatigue, myalgia, and leg weakness

treatment with colchicine

after


Input: This report describes a case of paradoxical, intravenous valproic acid-induced seizure exacerbation in a child with juvenile absence epilepsy, documented by video-electroencephalography.

intravenous valproic acid

seizure exacerbation

a child with juvenile absence epilepsy

induced


Input: She was treated with acyclovir and subsequently developed VZV antigen-positive zoster.

acyclovir

She

VZV antigen-positive zoster

developed


Input: CONCLUSIONS: In these 3 cases, the unique positive ocular finding was corneal endothelial deposits, which may be related to the use of rifabutin.

rifabutin

corneal endothelial deposits

may

related


Input: Response of a promethazine-induced coma to flumazenil.

promethazine

coma

induced

flumazenil

Response


Input: First, a review of the literature produced 41 anecdotic cases of neutropenia or agranulocytosis during treatment with olanzapine (Zyprexa) reported in a total of 24 publications.

neutropenia or agranulocytosis

olanzapine (Zyprexa)

41 anecdotic cases

during


Input: Neurologic degeneration associated with nitrous oxide anesthesia in patients with vitamin B12 deficiency.

Neurologic degeneration

nitrous oxide anesthesia

patients with vitamin B12 deficiency

associated


Input: Previous therapy with antiarrhythmics had resulted in intolerable adverse effects or no effect on the arrhythmia.

antiarrhythmics

intolerable adverse effects

resulted

antiarrhythmics

no

effect


Input: Allergic contact dermatitis to compound tincture of benzoin.

Allergic contact dermatitis

compound tincture of benzoin

to


Input: PURPOSE: To determine the cause of spontaneous choroidal hemorrhage in a 67-year-old man after a myocardial infarction and administration of tissue plasminogen activator.

spontaneous choroidal hemorrhage

67-year-old man after a myocardial infarction

tissue plasminogen activator

in


Input: Forty-one days later, she developed severe iatrogenic Cushing's syndrome due to the drug-drug interaction between triamcinolone and her boosted protease inhibitor therapy.

Forty-one days later

severe iatrogenic Cushing's syndrome

triamcinolone and her boosted protease inhibitor

she

severe

developed


Input: Pheripheral edema was observed in five female patients after taking proton pump inhibitors omeprazole, lansoprazole, or pantoprazole for 7-15 days for peptic acid diseases in recommended standard doses.

five female patients

Pheripheral edema

omeprazole, lansoprazole, or pantoprazole

taking


Input: We report the case of a child with metastatic osteosarcoma, who experienced an anaphylactic/anaphylactoid reaction to methotrexate.

anaphylactic/anaphylactoid reaction

methotrexate

a child with metastatic osteosarcoma

experienced


Input: It is tempting to speculate that interferon alpha may be involved in the pathogenesis of lichen nitidus.

interferon alpha

lichen nitidus

speculate

involved


Input: CONCLUSION: Alendronate led to nodular scleritis and rechallenge caused recurrence of scleritis.

Alendronate

nodular scleritis

led to


Input: A massive digitoxin (DGTX) intoxication in a 36-year-old man (35 mg DGTX) was treated by prolonged and repeated i.v.-infusions of Fab fragments of anti-digitalis antibodies (FAB).

prolonged and repeated i.v.-infusions of Fab fragments of anti-digitalis antibodies (FAB)

A massive digitoxin (DGTX) intoxication in a 36-year-old man (35 mg DGTX)

treated


Input: Gold-salt therapy may result in damage to proximal tubules that leak renal tubular antigens, which in turn complex with autoantibody and produce an autoimmune membranous nephropathy.

Gold-salt

damage to proximal tubules

may

result


Input: Only two case reports of adults with allergic contact dermatitis to this chemical exist in the literature, and we describe three more cases of children with recalcitrant atopic dermatitis found to have potential allergic contact dermatitis to bisabolol- a component of the Aquaphor emollient they were using to treat their atopic dermatitis.

three more cases of children with recalcitrant atopic dermatitis

potential allergic contact dermatitis

bisabolol- a component of the Aquaphor emollient

potential

have


Input: Recently, CD20-negative tumors have been described after Rituximab therapy.

Rituximab

CD20-negative tumors

after


Input: A 48-year-old woman who was treated for thyrotoxicosis with methimazole developed agranulocytosis.

A 48-year-old woman

methimazole

agranulocytosis

developed


Input: Methylene blue in the treatment and prevention of ifosfamide-induced encephalopathy: report of 12 cases and a review of the literature.

ifosfamide

encephalopathy

induced


Input: We report a case of a women in whom a malignant mixed mesodermal tumor was diagnosed while she was taking raloxifene, which is also a selective estrogen receptor modulator.

a women

a malignant mixed mesodermal tumor

while she was taking raloxifene

diagnosed


Input: Interactions between warfarin and cloxacillin can result in serious adverse reactions.

Interactions between warfarin and cloxacillin

serious adverse reactions

serious

result


Input: However, a large case-control study included three cases of either Stevens-Johnson syndrome or toxic epidermal necrolysis associated with ofloxacin use, but no details of the cases were given.

three cases

Stevens-Johnson syndrome or toxic epidermal necrolysis

ofloxacin

associated


Input: Acetazolamide may have accelerated the development of osteomalacia by several mechanisms, including increased renal calcium excretion.

Acetazolamide

osteomalacia

may

accelerated


Input: In conclusion, RSDS is a relevant osteoarticular complication in patients receiving either anticalcineurinic drug (CyA or tacrolimus), even under monotherapy or with a low steroid dose.

anticalcineurinic drug (CyA or tacrolimus)

RSDS

osteoarticular complication


Input: There have been several reported cases of omeprazole-induced AIN.

omeprazole

AIN

induced


Input: This interaction may be overlooked by clinicians, which may result in a serious bleeding risk for patients on warfarin.

serious bleeding risk

patients

warfarin

may

serious

result in


Input: Adriamycin-induced cardiomyopathy aggravated by cis-platinum nephrotoxicity requiring dialysis.

Adriamycin

cardiomyopathy

induced

cis-platinum

nephrotoxicity requiring dialysis

nephrotoxicity


Input: An 11-year-old boy who was treated with a relatively high dose of methotrimeprazine meleate (Levemepromazine) a phenothiazine antipsychotic drug, was admitted to the pediatric intensive care unit suffering from respiratory distress syndrome.

respiratory distress syndrome

relatively high dose of methotrimeprazine meleate (Levemepromazine)

An 11-year-old boy

suffering


Input: An adult male presented with central blindness after ingesting methanol.

An adult male

central blindness

ingesting methanol

presented


Input: All developed mucocutaneous side effects within 20 weeks of beginning im gold therapy, at a time when RA had improved markedly compared to pretreatment status.

im gold therapy

mucocutaneous side effects

beginning


Input: Two children, 1 with idiopathic nephrotic syndrome and 1 with endo-extracapillary glomerulonephritis, presented an episode of seizures and transient blindness at different times after i.v. pulse methylprednisolone (IVPMP) treatment.

Two children, 1 with idiopathic nephrotic syndrome and 1 with endo-extracapillary glomerulonephritis

seizures and transient blindness

i.v. pulse methylprednisolone (IVPMP) treatment

transient

after


Input: Stevens-Johnson syndrome in a boy with nephrotic syndrome during prednisolone therapy.

prednisolone

Stevens-Johnson syndrome

a boy with nephrotic syndrome

during


Input: To our knowledge, this is the first report of an angio-oedema associated with VRC.

angio-oedema

VRC

To our knowledge

associated


Input: Insulin-induced cardiac failure.

Insulin

cardiac failure

induced


Input: The symptoms disappeared with clemastine and betametasone treatment.

clemastine and betametasone

The symptoms disappeared

disappeared


Input: This report rules out other causes of toxic epidermal necrolysis and implicates ofloxacin in what appears to be an atypical presentation of drug-induced toxic epidermal necrolysis.

toxic epidermal necrolysis

ofloxacin

appears

drug-induced


Input: Controversy concerning the nephrotoxicity of lithium is discussed, and recommendations for the evaluation of renal failure during lithium therapy are provided.

nephrotoxicity

evaluation of renal failure

lithium

of


Input: A 56-year-old male parkinsonian patient developed a unique behavioral change following the oral administration of cinepazide, a cerebral vasodilator.

A 56-year-old male parkinsonian patient

a unique behavioral change

the oral administration of cinepazide, a cerebral vasodilator

developed


Input: The currently available clinical and neuropharmacologic data suggest that carbamazepine may be an antagonist of dopamine and that this property is responsible for the production of dystonia.

carbamazepine

dystonia

may

responsible


Input: Metamizole, a nonsteroidal antiinflammatory agent, is prohibited in the United States because of the risk of agranulocytosis but is widely used in Mexico and other countries.

Metamizole

agranulocytosis

risk


Input: We conclude that the use of hemopoietic colony stimulating factors might be a suitable means to achieve the correction of severe thionamide-induced hematologic adverse reactions.

thionamide

hematologic adverse reactions.

induced

hemopoietic colony stimulating factors

achieve


Input: Two case reports of bilateral granulomatous anterior uveitis are described in patients with open angle glaucoma treated with metripranolol 0.6% eye drops.

metripranolol 0.6% eye drops

Two case reports of bilateral granulomatous anterior uveitis

patients with open angle glaucoma

treated


Input: Regardless of a negative history of asthma, therefore, life-threatening bronchospasm must be considered a possible complication of propranolol therapy.

propranolol

life-threatening bronchospasm

possible

life-threatening

complication


Input: In the present paper the authors describe 2 female patients who developed incontinence secondary to the selective serotonin reuptake inhibitors paroxetine and sertraline, as well as a third who developed this side effect on venlafaxine.

2 female patients

incontinence

the selective serotonin reuptake inhibitors paroxetine and sertraline

developed


Input: Presented is a case story of a woman with classical rheumatoid arthritis, who during introduction of sulphasalazine (SASP) therapy developed a severe and lasting psoriasis-like skin reaction.

a woman with classical rheumatoid arthritis

during introduction of sulphasalazine (SASP) therapy

psoriasis-like skin reaction

severe

developed


Input: Interstitial granulomatous dermatitis associated with darifenacin.

Interstitial granulomatous dermatitis

darifenacin

associated


Input: Reversal of severe methanol-induced visual impairment: no evidence of retinal toxicity due to fomepizole.

methanol

visual impairment

severe

induced

fomepizole

retinal toxicity

no

due to


Input: Proton-pump inhibitors (PPIs) are believed to decrease the risk of such complications, though no randomized trial has proved this in patients receiving dual antiplatelet therapy.

Proton-pump inhibitors (PPIs)

believed


Input: The clinical course suggests that caffeine, which is present in oolong tea, was mainly responsible for the rhabdomyolysis as well as the delirium, although severe hyponatremia has been reported to cause rhabdomyolysis on rare occasions.

caffeine, which is present in oolong tea

rhabdomyolysis as well as the delirium

responsible


Input: Prevention of CNS relapse was satisfactorily achieved with HD IV MTX and intrathecal injections of MTX in children with increased-risk ALL or stage III and IV lymphoblastic lymphoma treated with our BFM-based treatment protocol in which cranial irradiation was omitted.

HD IV MTX and intrathecal injections of MTX

children with increased-risk ALL or stage III and IV lymphoblastic lymphoma

Prevention

children with increased-risk ALL or stage III and IV lymphoblastic lymphoma

our BFM-based treatment protocol in which cranial irradiation was omitted

treated


Input: Generalized lichen nitidus with involvement of the palms following interferon alpha treatment.

interferon alpha treatment

Generalized lichen nitidus with involvement of the palms

following


Input: Hemorrhagic cystitis is a significant toxic effect of cyclophosphamide therapy.

Hemorrhagic cystitis

cyclophosphamide

significant

significant toxic effect


Input: Secondary hyperparathyroidism in certain patients with lithium nephrotoxicity is also possible.

nephrotoxicity

Secondary hyperparathyroidism

certain patients

lithium

possible

in


Input: We report a case in which hemorrhage occurred in an asymptomatic falx meningioma known beforehand, after the internal use of low-dose aspirin for 16 months.

a case

low-dose aspirin for 16 months

hemorrhage

occurred


Input: Minor electrocardiographical changes were noted in five out of six patients who were not receiving a cardiac glycoside and four out of six who were receiving ouabain, and none of the 16 who were receiving digoxin.

four out of six

ouabain

electrocardiographical changes

Minor

receiving

electrocardiographical changes

cardiac glycoside

five out of six patients

not

receiving


Input: The allergic reaction started to develop after co-administration of pravastatin.

allergic reaction

co-administration of pravastatin

develop


Input: We propose that cyclophosphamide be added to the list of exposures potentially associated with hepatic angiosarcoma.

cyclophosphamide

hepatic angiosarcoma

potentially

associated


Input: The ocular motor disturbances are probably an expression of regional 5-FU neurotoxicity primarily affecting the brain stem.

The ocular motor disturbances

neurotoxicity

probably

expression


Input: Complications of chemotherapy for a synovial sarcoma in an eight-year old boy included cisplatinum nephrotoxicity and adriamycin cardiotoxicity.

an eight-year old boy

nephrotoxicity

cisplatinum

nephrotoxicity

an eight-year old boy

adriamycin

cardiotoxicity

cardiotoxicity


Input: Bacterial infection is a frequent event in renal transplant recipients and often requires the use of antimicrobial agents.

renal transplant recipients

Bacterial infection

antimicrobial agents

frequent

event


Input: Study results suggest that ciclesonide significantly reduces the need for OCS in patients with severe, persistent asthma, while maintaining asthma control.

ciclesonide

patients with severe, persistent asthma

reduces


Input: CONCLUSION: This is, to our knowledge, the first report of severe myelopathy following accidental intrathecal administration of doxorubicin.

severe myelopathy

intrathecal administration of doxorubicin

to our knowledge

following


Input: Multiple sclerosis-like disease secondary to alpha interferon.

alpha interferon

Multiple sclerosis-like disease

secondary


Input: We report a case of a patient with mild chronic renal insufficiency who had been taking simvastatin for over a year and developed acute weakness within 3 weeks after the start of treatment with colchicine for acute gouty bursitis.

a patient with mild chronic renal insufficiency

taking simvastatin for over a year

3 weeks after the start of treatment with colchicine for acute gouty bursitis

acute weakness

developed


Input: Shortly after chemotherapy and an injection of pegfilgrastim, the patient developed poorly defined, rapidly progressive erythema, edema, and pain in his right forearm.

pegfilgrastim

poorly defined, rapidly progressive erythema, edema, and pain in his right forearm

the patient

developed


Input: To describe a probable interaction between enteral feeds and levodopa leading to neuroleptic malignant-like syndrome (NMLS) in a polytrauma patient with Parkinson's disease (PD).

a polytrauma patient with Parkinson's disease (PD)

neuroleptic malignant-like syndrome (NMLS)

interaction between enteral feeds and levodopa

probable

leading


Input: Second, we report a case of neutropenia, which proved to be fatal in a schizophrenia patient receiving olanzapine and thiazide.

neutropenia

a schizophrenia patient

olanzapine and thiazide

fatal

receiving


Input: While mild to moderate application site reactions (ASRs) are a well-known and common phenomenon associated with imiquimod, the potential of TNF-alpha blockers to elicit cutaneous inflammatory reactions has only recently been recognized.

TNF-alpha blockers

cutaneous inflammatory reactions

potential

elicit

application site reactions (ASRs)

imiquimod

mild to moderate

associated


Input: Nineteen cases of allergic contact dermatitis to compound tincture of benzoin are described.

allergic contact dermatitis

compound tincture of benzoin

Nineteen cases

described


Input: We report 3 children with epilepsy who developed facial motor tics after initiation of CBZ for complex partial seizures.

3 children with epilepsy

facial motor tics

CBZ

after


Input: The toxicity of cadmium, zinc and cadmium/zinc mixtures at concentrations ranging from 1000 to 50000 microg/l were investigated against cercariae and metacercariae of Parorchis acanthus obtained from the dog whelk Nucella lapillus.

toxicity

cadmium, zinc and cadmium/zinc mixtures at concentrations ranging from 1000 to 50000 microg/l

against


Input: We report the syndrome of inappropriate antidiuresis as a much earlier side-effect of carbamazepine administration in a 29-year Nigerian female patient with generalized tonic-elonic seizures.

a 29-year Nigerian female patient with generalized tonic-elonic seizures

syndrome of inappropriate antidiuresis

carbamazepine

side-effect


Input: A patient was treated with warfarin for atrial fibrillation.

A patient

warfarin

treated


Input: Mood stabilizer therapy and pravastatin: higher risk for adverse skin reactions?

adverse skin reactions

Mood stabilizer therapy and pravastatin

risk

risk


Input: Pulmonary leukostasis secondary to all-trans retinoic acid in the treatment of acute promyelocytic leukemia in first relapse.

Pulmonary leukostasis

all-trans retinoic acid

secondary


Input: A 74-year-old hypercholestrerolaemic woman taking cerivastatin (0.15 mg/day) for 22 days complained of general muscle weakness and muscle pain.

A 74-year-old hypercholestrerolaemic woman

cerivastatin (0.15 mg/day)

general muscle weakness and muscle pain.

complained


Input: There have been only two reports of cimetidine-induced hepatitis.

hepatitis

cimetidine

induced


Input: A case is reported of theophylline intoxication due to a dramatic decrease in theophylline clearance following concomitant administration of viloxazine.

theophylline intoxication

concomitant administration of viloxazine

due


Input: Anterior ischemic optic neuropathy secondary to interferon alfa.

Anterior ischemic optic neuropathy

interferon alfa

secondary


Input: PURPOSE: To describe bilateral optic neuritis that occurred as an adverse effect of recombinant and natural interferon alpha administration.

bilateral optic neuritis

recombinant and natural interferon alpha administration

occurred


Input: Rofecoxib, used for dysmenorrhea, caused a herpetiform fixed drug eruption predominantly involving the lips with classic clinical and histological findings in a red-brown lesion on the dorsal hand.

Rofecoxib

herpetiform fixed drug eruption predominantly involving the lips with classic clinical and histological findings in a red-brown lesion on the dorsal hand

caused


Input: Statin-associated myasthenia gravis: report of 4 cases and review of the literature.

Statin

myasthenia gravis

4 cases

associated


Input: Two reports of spindle coma are noted with alcohol and imipramine.

Two reports

alcohol and imipramine

spindle coma

noted


Input: Cataracts induced by intermittent Decadron used as an antiemetic.

Cataracts

Decadron

induced


Input: Severe osteomalacia was present in two epileptic patients who were under long-term treatment with congeners of phenytoin, phenobarbital, and acetazolamide.

osteomalacia

two epileptic patients

long-term treatment with congeners of phenytoin, phenobarbital, and acetazolamide

Severe

present


Input: Careful observations on hepatotoxicity are suggested when acetaminophen is prescribed with caffeine.

hepatotoxicity

acetaminophen

caffeine

with


Input: Erosion of psoriatic plaques: an early sign of methotrexate toxicity.

methotrexate

Erosion of psoriatic plaques

of


Input: After extensive neurological 'work up', we realized that the anisocoria was related to the transdermal scopolamine patch that we had prescribed for weaning off the opioid.

anisocoria

transdermal scopolamine patch

related


Input: Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial.

tifacogin (recombinant tissue factor pathway inhibitor)

in


Input: CASE: A malignant mixed mesodermal tumor was diagnosed in a 64-year-old woman with a bicornuate uterus while she was taking raloxifene for osteoporosis prevention.

A malignant mixed mesodermal tumor

raloxifene

a 64-year-old woman with a bicornuate uterus

diagnosed


Input: After rechallenge with monotherapy pegvisomant, however, the hepatic enzyme disturbances reappeared within a few weeks, indicating that most likely pegvisomant alone and not the long-acting somatostatin analog or the combination of these two drugs was responsible for this case of drug-induced hepatitis.

pegvisomant

hepatic enzyme disturbances reappeared

hepatitis

responsible


Input: To evaluate the long-term (up to 5 years exposure) safety and efficacy of lacosamide as adjunctive therapy in patients with uncontrolled partial-onset seizures taking one to three concomitant antiepileptic drugs (AEDs) in open-label extension trial SP756 (NCT00522275).

long-term (up to 5 years exposure)

lacosamide as adjunctive therapy

taking one to three concomitant antiepileptic drugs (AEDs)

in


Input: Complete remission of the nephrosis occurred after discontinuation of hydroxychloroquine therapy.

discontinuation of hydroxychloroquine

nephrosis

occurred


Input: CONCLUSIONS: Clinicians treating elderly patients with olanzapine should be aware of the potential for rapidly developing hyperglycemia and monitor such patients accordingly.

olanzapine

rapidly developing hyperglycemia

elderly patients

potential

with


Input: We describe a case of PRES in a patient with collapsing focal glomeruloesclerosis (collapsing FGS) with complete recovery after withdrawal of cyclosporine (CSA).

a patient with collapsing focal glomeruloesclerosis (collapsing FGS)

withdrawal of cyclosporine (CSA)

complete recovery


Input: DISCUSSION: The occurrence of priapism in our patient was related to zuclopenthixol.

priapism

zuclopenthixol

our patient

related


Input: Hepatic angiosarcoma occurring after cyclophosphamide therapy: case report and review of the literature.

Hepatic angiosarcoma

cyclophosphamide therapy

occurring


Input: After completion of induction-consolidation phase, children with increased-risk (risk factor > 0.8 or T-lineage) ALL or stage III and IV lymphoblastic lymphoma were randomized to receive four courses of HD MTX (5 g/m(2) over 24 hours every 2 weeks) and four intrathecal administrations of MTX (Arm A) or the same treatment schedule with additional HD IV Ara-C (1 g/m(2) in bolus injection 12 and 24 hours after the start of each MTX infusion) (Arm B).

children with increased-risk (risk factor > 0.8 or T-lineage) ALL or stage III and IV lymphoblastic lymphoma

After completion of induction-consolidation phase

four courses of HD MTX (5 g/m(2) over 24 hours every 2 weeks) and four intrathecal administrations of MTX (Arm A) or the same treatment schedule with additional HD IV Ara-C (1 g/m(2) in bolus injection 12 and 24 hours after the start of each MTX infusion) (Arm B)

receive


Input: The dose-limiting toxicity of KW-2149 is pulmonary toxicity.

pulmonary

toxicity


Input: Flucloxacillin-induced aplastic anaemia and liver failure.

Flucloxacillin

aplastic anaemia and liver failure

induced


Input: Thus, we confirm that desensitization may be a safe procedure in patients with cancer who experience methotrexate-induced anaphylaxis.

patients with cancer

methotrexate

anaphylaxis

induced


Input: We further used immunohistochemistry (IHC) to examine the relative role of platelet-derived growth factor-B (PDGF-B), insulin-like growth factor I (IGF-I), transforming growth factor-beta1 (TGF-beta1) and cyclooxygenase-2 (COX-2) in the pathogenesis of BCNU-related pulmonary fibrosis.

BCNU

pulmonary fibrosis

related


Input: Physicians using this "new" drug must be aware of the potential danger of sulfonamide-induced injury to the urinary tract.

sulfonamide

injury to the urinary tract

potential

induced


Input: RESULTS: Brimonidine was observed to cause IOP elevation, confirmed on rechallenge, scoring 8 (strong probability) on an adverse drug reaction probability score.

Brimonidine

IOP elevation

cause


Input: Severe leukopenia associated with mild hepatotoxicity in an HIV carrier treated with nevirapine.

an HIV carrier

nevirapine

leukopenia

Severe

with


Input: The clinical effect and safety of Lp-TAE alone and combined with radiofrequency (RF) capacitive hyperthermia (HT) were evaluated in 20 patients with hepatocellular carcinoma (HCC) associated with cirrhosis of the liver.

Lp-TAE alone and combined with radiofrequency (RF) capacitive hyperthermia (HT)

20 patients with hepatocellular carcinoma (HCC)

evaluated

effect and safety


Input: Fibrosis of corpus cavernosum after intracavernous injection of phentolamine/papaverine.

Fibrosis of corpus cavernosum

intracavernous injection of phentolamine/papaverine

after


Input: We have cared for three children in whom four episodes of dystonia proceeding to opisthotonus occurred in association with carbamazepine use.

carbamazepine

three children

four episodes of dystonia proceeding to opisthotonus

occurred


Input: Juvenile absence epilepsy exacerbated by valproic acid.

valproic acid

Juvenile absence epilepsy exacerbated

Juvenile absence epilepsy

exacerbated


Input: These cases were chosen for study because they were all deaths as a result of suicidal ingestion of drugs in which quetiapine was considered a significant factor.

quetiapine

they were all deaths

deaths

considered


Input: We present a case of hypereosinophilia related to zafirlukast therapy.

zafirlukast therapy.

hypereosinophilia

a case

related


Input: In patients with methotrexate-induced anaphylaxis, discontinuation of treatment may increase the risk of death due to cancer progression.

treatment

In patients with methotrexate-induced anaphylaxis

death due to cancer progression

may

discontinuation

methotrexate

anaphylaxis

induced


Input: Pentazocine-induced fibrous myopathy and localized neuropathy.

Pentazocine

fibrous myopathy and localized neuropathy

induced


Input: Intensive high-flux hemodiafiltration is often used in the management of vancomycin toxicity.

Intensive high-flux hemodiafiltration

management


Input: Here we present the case of a generalized lichen nitidus with involvement of the palms in a patient with hepatitis C after systemic treatment with interferon alpha and ribavirin.

a generalized lichen nitidus with involvement of the palms

a patient with hepatitis C

systemic treatment with interferon alpha and ribavirin

after


Input: The authors describe a woman with chronic schizophrenia who experienced delirium, grand mal seizure, and photosensitivity after the addition of propranolol to her neuroleptic regimen.

a woman with chronic schizophrenia

delirium, grand mal seizure, and photosensitivity

propranolol

after


Input: We report a case of an infant with complex congenital heart disease who was placed on captopril for afterload reduction following cardiac surgery and subsequently developed pulmonary infiltrates with eosinophilia.

an infant with complex congenital heart disease

captopril

pulmonary infiltrates with eosinophilia

developed


Input: Possible pathophysiological mechanisms which may have been operative in this case include: a direct central nervous system (CNS) toxic effect of valproic acid; a paradoxical epileptogenic effect secondary to the drug; and an indirect CNS toxic effect mediated through valproic acid-induced hyperammonemia.

a direct central nervous system (CNS) toxic effect

a paradoxical epileptogenic effect

hyperammonemia

valproic acid

induced


Input: We report a case of serotonin syndrome induced by pharmacokinetic and pharmacodynamic interactions between three different selective serotonin-reuptake inhibitors (SSRI) and possibly ciprofloxacin.

a case

serotonin syndrome

interactions between three different selective serotonin-reuptake inhibitors (SSRI) and possibly ciprofloxacin

possibly

induced


Input: Generalised pustular psoriasis induced by cyclosporin a withdrawal responding to the tumour necrosis factor alpha inhibitor etanercept.

Generalised pustular psoriasis

cyclosporin a withdrawal

induced

the tumour necrosis factor alpha inhibitor etanercept

responding


Input: A 36-y-o patient with schizophrenia, who had consumed gradually increasing quantities of oolong tea that eventually reached 15 L each day, became delirious and was admitted to a psychiatric hospital.

A 36-y-o patient with schizophrenia

gradually increasing quantities of oolong tea that eventually reached 15 L each day

delirious

became


Input: Intraventricular nafcillin-induced seizures in a neonate.

nafcillin

Intraventricular

seizures

a neonate

induced


Input: Nevertheless, the coagulopathy seemed to be most closely associated with the administration of the cephalosporin.

cephalosporin

coagulopathy

seemed

associated with


Input: Intrahepatic cholestasis and sicca complex after thiabendazole.

Intrahepatic cholestasis and sicca complex

thiabendazole

after


Input: We recommended periodic examination of the serum proteins in patients receiving diphenylhydantoin in order to detect development of monoclonal gammopathy.

patients

diphenylhydantoin

detect development of monoclonal gammopathy

receiving


Input: Moxalactam is more likely to be associated with platelet dysfunction.

Moxalactam

platelet dysfunction

more likely

associated


Input: This prompted us to suspect that ddI might be responsible for fulminant hepatitis in all three AIDS patients.

ddI

fulminant hepatitis

three AIDS patients

might

be responsible for


Input: Two patients, each receiving warfarin for stroke prophylaxis in association with chronic atrial fibrillation, developed adverse effects after the initiation of tolterodine for urinary disorders.

Two patients

receiving warfarin for stroke prophylaxis in association with chronic atrial fibrillation

after the initiation of tolterodine for urinary disorders

adverse effects

developed


Input: CASE SUMMARY: A 45-year-old HIV-positive man (CD4+ count 450 cells/mm(3) and history of AIDS-defining illness) presented with JHR after an initial intravenous dose of penicillin G for presumed neurosyphilis.

A 45-year-old HIV-positive man (CD4+ count 450 cells/mm(3) and history of AIDS-defining illness)

JHR

an initial intravenous dose of penicillin G

after


Input: The second patient developed both autoimmune thyroid disease and a refractory pre-patellar bursitis after 50 months of IFN-beta therapy.

second patient

both autoimmune thyroid disease and a refractory pre-patellar bursitis

50 months of IFN-beta therapy

developed


Input: We report an additional case of isotretinoin teratogenicity in which the patient had agenesis of the cerebellar vermis, multiple leptomeningeal neuroglial heterotopias, hydrocephalus, and abnormalities of the corticospinal tracts.

isotretinoin

patient

agenesis of the cerebellar vermis, multiple leptomeningeal neuroglial heterotopias, hydrocephalus, and abnormalities of the corticospinal tracts

teratogenicity


Input: Reversible sclerotic changes of lumbar spine and femur due to long-term oral isotretinoin therapy.

Reversible sclerotic changes of lumbar spine and femur

long-term oral isotretinoin

due


Input: A case of priapism associated with trazodone is described.

A case

priapism

trazodone

associated


Input: Severe adenovirus pneumonia (AVP) following infliximab infusion for the treatment of Crohn's disease.

adenovirus pneumonia

infliximab infusion

Severe

following


Input: No other endogenous or exogenous cause for the gynecomastia could be found except for the theophylline.

theophylline

gynecomastia

cause


Input: This is a case of pseudoephedrine-induced intracerebral hemorrhage in a patient with an underlying vascular malformation.

pseudoephedrine

intracerebral hemorrhage

a patient with an underlying vascular malformation

induced


Input: A 58-year-old woman developed unilateral acute angle-closure glaucoma four days after the application of a patch of transdermal scopolamine delivery system (TRANSDERM-V).

four days after the application of a patch of transdermal scopolamine delivery system (TRANSDERM-V)

A 58-year-old woman

unilateral acute angle-closure glaucoma

after


Input: We report a 50-year-old male patient with a 15-year history of psoriasis including mutilating psoriatic arthritis, in whom the withdrawal of cyclosporin A induced a generalised pustular exacerbation and a aggravation of the joint condition.

a 50-year-old male patient with a 15-year history of psoriasis including mutilating psoriatic arthritis

the withdrawal of cyclosporin A

a generalised pustular exacerbation and a aggravation of the joint condition

induced


Input: Six days after starting acyclovir she exhibited signs of lithium toxicity.

she

lithium toxicity

Six days after starting acyclovir

after


Input: Toxicity of cadmium and zinc to encystment and in vitro excystment of Parorchis acanthus (Digenea: Philophthalmidae).

cadmium and zinc

Toxicity

Toxicity


Input: The syndrome of irreversible lithium-effectuated neurotoxicity (SILENT).

syndrome of irreversible lithium-effectuated neurotoxicity (SILENT)

lithium

effectuated


Input: One patient on ouabain also developed cardiomyopathy.

One patient

ouabain

cardiomyopathy

developed


Input: Data suggest that tamoxifen is involved in the pathogenesis.

tamoxifen

pathogenesis

suggest

involved


Input: Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy.

Intrahepatic cholestasis and cutaneous bullae

glibenclamide therapy

associated


Input: Prolonged-release oxycodone enhances the effects of existing gabapentin therapy in painful diabetic neuropathy patients.

Prolonged-release oxycodone

gabapentin therapy

painful diabetic neuropathy patients

enhances


Input: OBJECTIVE: To describe what is believed, as of November 4, 2003, to be the first case published in the literature of acute interstitial nephritis (AIN) due to pantoprazole.

pantoprazole

acute interstitial nephritis (AIN)

acute

due


Input: We report a patient of organic bipolar affective disorder who developed hiccups with the atypical antipsychotic aripiprazole.

a patient of organic bipolar affective disorder

hiccups

the atypical antipsychotic aripiprazole

developed


Input: A 28 year-old man with chronic hepatitis B was administered interferon-alpha (5 x 10(6) IU) intramuscularly once a day for 28 days.

interferon-alpha (5 x 10(6) IU) intramuscularly once a day for 28 days

A 28 year-old man with chronic hepatitis B

administered


Input: The case of a patient taking high-dosage olanzapine who experienced parkinsonism after smoking cessation is reported.

a patient

high-dosage olanzapine

smoking cessation

parkinsonism

experienced


Input: A 65-year-old woman with bipolar disorder and complicated cardiovascular disease who was on maintenance lithium therapy developed a movement disorder following high doses of trazodone for treatment of an acute depression.

high doses of trazodone

a movement disorder

A 65-year-old woman with bipolar disorder and complicated cardiovascular disease who was on maintenance lithium therapy

following


Input: The most common complication of warfarin use is adverse bleeding.

adverse bleeding

warfarin

use


Input: To report a case of autonomic, neurological and neuromuscular instability following methylene blue infusion for parathyroidectomy; to advance the argument for a diagnosis of serotonin syndrome; and to consider this diagnosis in previous, unexplained reports of adverse reactions amongst patients undergoing parathyroidectomy using methylene blue.

methylene blue infusion for parathyroidectomy

autonomic, neurological and neuromuscular instability

following


Input: PVT during chemotherapy in children is a rare event and appears to be closely related to intensive chemotherapy containing busulfan and to be associated with HVOD.

PVT

intensive chemotherapy containing busulfan and to be associated with HVOD

HVOD

appears

related


Input: It is hoped that this case report creates awareness that ofloxacin-induced toxic epidermal necrolysis is possible.

ofloxacin

toxic epidermal necrolysis is possible

possible

induced


Input: Concomitant use of simvastatin and amiodarone resulting in severe rhabdomyolysis: a case report and review of the literature.

rhabdomyolysis

Concomitant use of simvastatin and amiodarone

a case

severe

resulting


Input: CONCLUSIONS: This report indicates clindamycin phosphate vaginal cream as the most probable cause of CDIC due to the temporal relationship between the occurrence of diarrhea and clindamycin administration, lack of concomitant medications, and documentation of C. difficile toxin.

clindamycin phosphate vaginal cream

CDIC

probable

cause


Input: A case of intercerebral hematoma due to warfarin-induced coagulopathy is presented.

warfarin

coagulopathy

intercerebral hematoma

induced


Input: Severe visual loss after a single dose of vincristine in a patient with spinal cord astrocytoma.

Severe visual loss

a single dose of vincristine

a patient with spinal cord astrocytoma

Severe

after


Input: Clonazepam, thioridazine, beta-blockers, anticholinergics, and bromocriptine did not ameliorate his akathisia.

Clonazepam, thioridazine, beta-blockers, anticholinergics, and bromocriptine

his

not

ameliorate


Input: Musculoskeletal complaints were the presenting symptoms in four of 44 children (9%) treated for relapsed Wilms' tumors with ifosfamide, a derivative of cyclophosphamide.

ifosfamide

Musculoskeletal complaints

four of 44 children (9%)

with


Input: Cutaneous exposure to warfarin-like anticoagulant causing an intracerebral hemorrhage: a case report.

Cutaneous exposure to warfarin-like anticoagulant

an intracerebral hemorrhage

a case

causing


Input: Gemcitabine should be added to the list of drugs known to cause radiation recall.

Gemcitabine

radiation recall

cause


Input: A paradoxical ocular effect of brimonidine.

paradoxical ocular effect

brimonidine

of


Input: Fixed drug eruption to rofecoxib.

Fixed drug eruption

rofecoxib

to


Input: DISCUSSION: No published clinical studies in patients receiving clindamycin vaginal cream for bacterial vaginosis have documented C. difficile toxin in stool samples of patients with diarrhea.

receiving clindamycin vaginal cream

patients

for


Input: Acute interstitial nephritis due to pantoprazole.

Acute interstitial nephritis

pantoprazole

due


Input: Physicians should keep in mind that taxanes such as paclitaxel have the potential to cause pneumonitis and lung fibrosis.

taxanes such as paclitaxel

pneumonitis and lung fibrosis

potential

cause


Input: Infant twins sustained severe circumoral and pharyngeal burns from a concentrated solution of benzalkonium (Zephiran) chloride prescribed for treatment of candidiasis.

Infant twins

severe circumoral and pharyngeal burns

a concentrated solution of benzalkonium (Zephiran) chloride

severe

sustained


Input: Isotretinoin teratogenicity.

Isotretinoin

teratogenicity

Isotretinoin teratogenicity


Input: Hepatitis following cimetidine administration.

Hepatitis

cimetidine

following


Input: We report the case of an 11-month-old female infant with a depressed level of consciousness after ingestion of ibuprofen whose mental status markedly improved with administration of naloxone.

an 11-month-old female infant

a depressed level of consciousness

ingestion of ibuprofen

after


Input: Investigation confirmed the diagnosis of rhabdomyolysis, and discontinuation of colchicine resulted in resolution of clinical and biochemical features of rhabdomylysis.

colchicine

rhabdomylysis

resulted


Input: A 73 year-old patient with Wolff-Parkinson-White syndrome and paroxysmic supraventricular tachycardia developed an acute reversible encephalopathy within 15 days of initiation of flecainide.

73 year-old patient with Wolff-Parkinson-White syndrome and paroxysmic supraventricular tachycardia

acute reversible encephalopathy

flecainide

acute

developed


Input: Since the depressive symptoms returned sertraline medication was initiated.

sertraline

initiated


Input: Supravenous hyperpigmentation in association with CHOP chemotherapy of a CD30 (Ki-1)-positive anaplastic large-cell lymphoma.

Supravenous hyperpigmentation

CHOP chemotherapy

association


Input: A 33-year-old male presented with brown discolouration of the fingernails following the application of 4% hydroquinone in sorbolene cream and 0.1% tretinoin cream to the face intermittently for 9 months.

A 33-year-old male

brown discolouration of the fingernails

4% hydroquinone in sorbolene cream and 0.1% tretinoin cream to the face intermittently for 9 months

application


Input: We describe two cases of sulfadiazine-induced crystalluria and renal failure in patients with acquired immunodeficiency syndrome, review the pertinent literature, and discuss the pathogenesis.

two cases

patients with acquired immunodeficiency syndrome

sulfadiazine

crystalluria and renal failure

induced


Input: Acute eosinophilic pneumonia caused by calcium stearate, an additive agent for an oral antihistaminic medication.

calcium stearate, an additive agent for an oral antihistaminic medication

Acute eosinophilic pneumonia

caused


Input: The cause of death was determined to be acute intoxication by olanzapine, and the manner of death was accidental.

death

acute intoxication

olanzapine

by


Input: Long lasting respiratory depression induced by morphine-6-glucuronide?

Long lasting respiratory depression

induced


Input: A toxic encephalopathy characterized by depressed level of consciousness, marked irritability, and ataxia developed in seven children, 5 years of age and younger, following administration of an antiemetic combination of pentobarbital and pyrilamine maleate.

administration of an antiemetic combination of pentobarbital and pyrilamine maleate

A toxic encephalopathy characterized by depressed level of consciousness, marked irritability, and ataxia

seven children, 5 years of age and younger

developed


Input: Oculomotor disturbances associated with 5-fluorouracil chemotherapy.

Oculomotor disturbances

5-fluorouracil chemotherapy

associated


Input: While doxorubicin was administered, the patient presented thoracic pain and breathing distress due to superior vena cava perforation by the central catheter and subsequent extravasation of the drug into the mediastinum.

doxorubicin

patient

thoracic pain and breathing distress

presented


Input: An 18-year-old Japanese man weighing 53 kg with an anaplastic large cell lymphoma received continuous IV administration of TAC as post-transplantation prophylaxis against graft-versus-host disease (GVHD) after an allogeneic bone marrow transplantation (BMT).

An 18-year-old Japanese man weighing 53 kg with an anaplastic large cell lymphoma

received continuous IV administration of TAC

allogeneic bone marrow transplantation (BMT)

graft-versus-host disease (GVHD)

prophylaxis


Input: Intravenous administration of levodopa ameliorated a refractory akathisia case induced by interferon-alpha.

Intravenous administration of levodopa

ameliorated

interferon-alpha.

refractory akathisia

induced


Input: Patients with lymphoblastic lymphoma who had treatment with L-asparaginase and steroid are predisposed to the development of cortical venous thrombosis and may have this syndrome in addition to a dural puncture headache.

L-asparaginase and steroid

cortical venous thrombosis

dural puncture headache

Patients with lymphoblastic lymphoma

may

predisposed


Input: Because sumatriptan can cause coronary artery vasospasm, patients with significant risk factors for coronary artery disease should be carefully evaluated for cardiovascular disease prior to the use of sumatriptan.

sumatriptan

coronary artery vasospasm

cause


Input: This article describes the case of a 25-year-old man found dead at home who had been prescribed olanzapine for schizophrenia.

25-year-old man

schizophrenia

dead

olanzapine

found


Input: A 67-year-old man developed diarrhea shortly after a 10-day course of oral ampicillin.

A 67-year-old man

diarrhea

a 10-day course of oral ampicillin

developed


Input: Prominent positive U waves appearing with high-dose intravenous phenylephrine.

Prominent positive U waves

high-dose intravenous phenylephrine

appearing


Input: Severe acidosis in patients taking metformin--rapid reversal and survival despite high APACHE score.

metformin

Severe acidosis

patients

taking


Input: Seizures and transient blindness following intravenous pulse methylprednisolone in children with primary glomerulonephritis.

Seizures and transient blindness

intravenous pulse methylprednisolone

children with primary glomerulonephritis

following


Input: We report on a patient with acromegaly who developed severe drug-induced hepatitis during combined treatment with the long-acting somatostatin-analog octreotide and the GH receptor antagonist pegvisomant.

hepatitis

long-acting somatostatin-analog octreotide

GH receptor antagonist pegvisomant

a patient with acromegaly

severe

developed


Input: The primary efficacy population consisted of 1754 patients (> or =18 years) with severe sepsis and a high INR (> or =1.2) randomly assigned to intravenous infusion of either tifacogin (0.025 mg/kg per hour for 96 hours, n = 880) or placebo (arginine citrate buffer, n = 874), and 201 patients with a low INR (<1.2) randomly assigned to receive the same dose of either tifacogin or placebo.

1754 patients (> or =18 years) with severe sepsis and a high INR

tifacogin

assigned


Input: We report a case of a 23-year-old man who developed a vancomycin-induced anaphylactic reaction in the treatment of methicillin-resistant Staphylococcus aureus infection.

a 23-year-old man

vancomycin

a vancomycin-induced anaphylactic reaction

developed


Input: Recovery of the tubular dysfunction took 15 days following cessation of the offending drug, Amikacin.

15 days following cessation of the offending drug, Amikacin

Recovery


Input: L-asparaginase-induced pancreatitis has been reported during or closely following administration of the drug.

L-asparaginase

pancreatitis

induced


Input: These novel findings may offer specific therapeutic targets in the treatment of BCNU-associated pulmonary fibrosis.

pulmonary fibrosis

BCNU

associated


Input: A 58-year-old man with advanced renal cell carcinoma developed grade 3 proteinuria (8.5 g/24 h) without microscopic hematuria or renal insufficiency five days after temsirolimus infusion.

A 58-year-old man with advanced renal cell carcinoma

grade 3 proteinuria (8.5 g/24 h) without microscopic hematuria or renal insufficiency

five days after temsirolimus infusion

developed


Input: A 2-year-old mentally retarded boy with frontal lobe epilepsy presented with an episode that resembled heat stroke during the administration of zonisamide.

zonisamide

A 2-year-old mentally retarded boy with frontal lobe epilepsy

an episode that resembled heat stroke

resembled

during


Input: [Serotonin syndrome following methylene blue infusion during parathyroidectomy: a case report and literature review].

Serotonin syndrome

methylene blue infusion during parathyroidectomy

following


Input: Two patients treated with 5-fluorouracil (5-FU) for disseminated adenocarcinoma of the colon developed cerebellar dysfunction typical of 5-FU neurotoxicity.

5-fluorouracil (5-FU)

Two patients

cerebellar dysfunction

treated


Input: Once extensive microbiological studies proved negative, corticosteroids were given and a complete remission of clinical and radiological abnormalities was achieved.

corticosteroids

a complete remission of clinical and radiological abnormalities was achieved

achieved


Input: Disseminated muscular cysticercosis with myositis induced by praziquantel therapy.

Disseminated muscular cysticercosis with myositis

praziquantel therapy

induced


Input: Cardiomyopathy after widely separated courses of adriamycin exacerbated by actinomycin-D and mithramycin.

Cardiomyopathy

exacerbated

widely separated courses of adriamycin

actinomycin-D and mithramycin

exacerbated


Input: Linear immunoglobulin A bullous dermatosis induced by gemcitabine.

gemcitabine

Linear immunoglobulin A bullous dermatosis

induced


Input: The temporal association of the course of tolterodine with an elevated INR, the return to the previous warfarin dose-INR response relationship after tolterodine discontinuation, and the absence of other causes for the elevated INR were factors found in both patients.

tolterodine

elevated INR

both patients

temporal association

course

both patients

tolterodine discontinuation

return to the previous warfarin dose-INR response relationship

return


Input: The harlequin color change and association with prostaglandin E1.

harlequin color change

prostaglandin E1

association


Input: A case of tuberculosis in a patient on Efalizumab and Etanercept for treatment of refractory palmopustular psoriasis and psoriatic arthritis.

Efalizumab and Etanercept

a patient

tuberculosis

treatment


Input: Although the two local anesthetics usually do not cause methemoglobinemia, we suspect that the displacement of lidocaine from protein binding by bupivacaine, in combination with metabolic acidosis and treatment with other oxidants, was the reason for the development of methemoglobinemia.

methemoglobinemia

the displacement of lidocaine from protein binding by bupivacaine, in combination with metabolic acidosis and treatment with other oxidants

suspect

reason


Input: Nephrotic range pseudoproteinuria in a tolmetin-treated patient.

Nephrotic range pseudoproteinuria

tolmetin

patient

in


Input: With the first cyclosporine dose, the patient complained of leg pain that was most severe during the cyclosporine infusion.

first cyclosporine dose

leg pain

With

complained


Input: We report on a patient who developed acute rhabdomyolysis after taking cerivastatin.

cerivastatin

a patient

acute rhabdomyolysis

after


Input: In a patient suffering from rheumatoid arthritis, we report the first simultaneous occurrence of two side effects of low-dose methotrexate: an acute megaloblastic anaemia and a pneumonitis.

patient suffering from rheumatoid arthritis

acute megaloblastic anaemia and a pneumonitis

low-dose methotrexate

acute

an


Input: We describe a 57-year-old man with acral erythrocyanosis progressing to acute digital ischemia and gangrene that developed after combined chemotherapy (bleomycin and methotrexate) used to treat a metastatic squamous cell carcinoma of the hypopharynx.

a 57-year-old man with acral erythrocyanosis

acute digital ischemia and gangrene

combined chemotherapy (bleomycin and methotrexate)

developed


Input: We report a case of long lasting respiratory depression after intravenous administration of morphine to a 7 year old girl with haemolytic uraemic syndrome.

a case of long lasting respiratory depression

intravenous administration of morphine

a 7 year old girl with haemolytic uraemic syndrome

long lasting

after


Input: Although adverse effects are usually mild, the author reports here a case of leucocytopenia and thrombocytopenia with quetiapine treatment that required its discontinuation.

quetiapine

leucocytopenia and thrombocytopenia

a case

with


Input: Noncardiogenic pulmonary edema during intrabiliary infusion of mono-octanoin.

Noncardiogenic pulmonary edema

intrabiliary infusion of mono-octanoin

during


Input: Cardiac glycosides are thought to prevent doxorubicin cardiomyopathy by competitively inhibiting doxorubicin at its receptor sites, but ouabain has a much shorter half life than doxorubicin and its metabolites and so is less effective than digoxin.

Cardiac glycosides

thought to


Input: Three hundred and thirty eight patients with moderate to severe painful diabetic neuropathy despite receiving their maximum tolerated dose of gabapentin, had oral prolonged-release oxycodone or placebo tablets added to their therapy for up to 12 weeks.

Three hundred and thirty eight patients with moderate to severe painful diabetic neuropathy

gabapentin

oral prolonged-release oxycodone or placebo tablets added to their therapy for up to 12 weeks

receiving


Input: We assessed the bleeding risk in patients treated with thromboprophylactic dabigatran etexilate, with and without concomitant NSAID or ASA.

thromboprophylactic dabigatran etexilate, with and without concomitant NSAID or ASA

bleeding

patients

treated


Input: Dapsone-induced erythroderma with Beau's lines.

Dapsone

erythroderma with Beau's lines

induced


Input: Methotrexate-induced hepatic necrosis requiring liver transplantation in a patient with rheumatoid arthritis.

a patient with rheumatoid arthritis

Methotrexate

hepatic necrosis

induced


Input: We present three cases from the Provincial Toxicology Center of British Columbia, Canada in which suicidal overdose deaths were associated with quetiapine.

quetiapine

suicidal overdose deaths

associated


Input: Both patients developed hypoadrenalism while on o,p'-DDD and apparently adequate dexamethasone replacement therapy.

Both patients

hypoadrenalism

o,p'-DDD and apparently adequate dexamethasone replacement therapy

developed


Input: In the other patient, a 78-year-old woman, Neisseria mucosa knee arthritis occurred after a single sodium hyaluronate injection.

a 78-year-old woman

Neisseria mucosa knee arthritis

a single sodium hyaluronate injection

occurred


Input: Implanon   failure in an HIV-positive woman on antiretroviral therapy resulting in two ectopic pregnancies.

an HIV-positive woman

two ectopic pregnancies

Implanon   failure

on antiretroviral therapy

resulting


Input: Massive prolapse of the urethral mucosa following periurethral injection of calcium hydroxylapatite for stress urinary incontinence.

Massive prolapse of the urethral mucosa

periurethral injection of calcium hydroxylapatite

following


Input: A 35-year-old female with borderline lepromatous (BL) leprosy who suffered from dapsone-induced erythroderma is reported.

dapsone

A 35-year-old female with borderline lepromatous (BL) leprosy

erythroderma

induced


Input: Well-known signs of methotrexate toxicity include bone marrow suppression and oral and gastrointestinal ulceration.

methotrexate

bone marrow suppression and oral and gastrointestinal ulceration

signs


Input: Hemorrhage from a falx meningioma after internal use of low-dose aspirin.

Hemorrhage from a falx meningioma

internal use of low-dose aspirin

after


Input: Severe respiratory syncytial virus pulmonary infection in a patient treated with fludarabine for chronic lymphocytic leukemia.

Severe respiratory syncytial virus pulmonary infection

a patient

fludarabine

Severe

treated


Input: Nonsustained polymorphous ventricular tachycardia during amiodarone therapy for atrial fibrillation complicating cardiomyopathy.

Nonsustained polymorphous ventricular tachycardia

amiodarone therapy

during


Input: Severe abdominal pain in low dosage clofazimine.

low dosage clofazimine

abdominal pain

Severe

in


Input: Behavioral side effects associated with clonazepam may include agitation, aggression, hyperactivity, irritability, property destruction, and temper tantrums.

clonazepam

agitation, aggression, hyperactivity, irritability, property destruction, and temper tantrums

may

associated


Input: Coagulopathy associated with the use of cephalosporin or moxalactam antibiotics in acute and chronic renal failure.

Coagulopathy

cephalosporin or moxalactam antibiotics

associated


Input: Pamidronate therapy should be considered in patients with hypercalcemia secondary to acute vitamin D poisoning.

hypercalcemia

vitamin D

secondary

Pamidronate

therapy


Input: Use of the Naranjo probability scale indicated a highly probable relationship between the observed cardiac toxicity and amphotericin B deoxycholate therapy in this patient.

amphotericin B deoxycholate

patient

cardiac toxicity

highly probable

relationship


Input: Captopril-induced pulmonary infiltrates with eosinophilia in an infant with congenital heart disease.

Captopril

pulmonary infiltrates with eosinophilia

an infant with congenital heart disease

induced


Input: Chronic fentanyl application induces adrenocortical insufficiency.

adrenocortical insufficiency

Chronic fentanyl

induces


Input: After discontinuing captopril and starting systemic steroids, her symptomatology rapidly improved, and her eosinophilia and radiographic abnormalities both resolved.

discontinuing captopril and starting systemic steroids

her eosinophilia and radiographic abnormalities both resolved

resolved


Input: We present a surprising case of a woman schizophrenic patient treated with clozapine suffering from EPS.

clozapine

EPS

a woman schizophrenic patient

suffering


Input: Therefore, we concluded that this patient's pulmonary disease was caused by calcium stearate, an additive for an antihistaminic drug.

this patient's

pulmonary disease

calcium stearate

an additive for an antihistaminic drug

caused


Input: Benzocaine-induced methemoglobinemia has been reported in man, dogs, and cats.

man, dogs, and cats

Benzocaine

methemoglobinemia

induced


Input: We report two cases of fulminant hepatic failure in HIV-1-infected patients treated with didanosine (ddI).

fulminant hepatic failure

HIV-1-infected patients

didanosine (ddI)

fulminant

of


Input: Leflunomide-associated weight loss in rheumatoid arthritis.

Leflunomide

weight loss

associated


Input: Antiretroviral-induced hepatic steatosis and lactic acidosis: case report and review of the literature.

Antiretroviral

hepatic steatosis and lactic acidosis

case

induced


Input: A woman developed delusional parasitosis when taking phenelzine.

A woman

delusional parasitosis

phenelzine

developed


Input: Percutaneous absorption of warfarin causing coagulopathy, reported three times in the past, is a significant risk if protective measures, such as gloves, are not used.

coagulopathy

Percutaneous absorption of warfarin

a significant risk

causing


Input: We present two cases of nitrofurantoin-induced pulmonary toxicity in which the initial HRCT showed a widespread reticular pattern and associated distortion of the lung parenchyma, thought to represent established fibrosis.

pulmonary toxicity in which the initial HRCT showed a widespread reticular pattern and associated distortion of the lung parenchyma, thought to represent established fibrosis

nitrofurantoin

induced


Input: Colchicine-induced rhabdomyolysis.

Colchicine

rhabdomyolysis

induced


Input: We report a case of severe AVP three weeks following the administration of infliximab for the treatment of Crohn's disease (CD).

AVP

infliximab

severe

following


Input: In each patient, the initiation of tolterodine was associated with a significant increase in the patient's INR measured 10-14 days later.

significant increase in the patient's INR

the initiation of tolterodine

each patient

associated with


Input: DATA SYNTHESIS: Genetic deficiencies in DPD, the rate-limiting enzyme responsible for 5-FU catabolism, may occur in 3% or more of patients with cancer putting them at increased risk for unusually severe adverse reactions (e.g., diarrhea, stomatitis, mucositis, myelosuppression, neurotoxicity) to standard doses of 5-FU.

Genetic deficiencies in DPD, the rate-limiting enzyme responsible for 5-FU catabolism, may occur in 3% or more of patients with cancer

standard doses of 5-FU

increased risk for unusually severe adverse reactions (e.g., diarrhea, stomatitis, mucositis, myelosuppression, neurotoxicity)

putting


Input: According to the Drug Interaction Probability Scale, the development of supratherapeutic INRs was probably associated with concomitant acetaminophen and moxifloxacin use.

concomitant acetaminophen and moxifloxacin use

development of supratherapeutic INRs

probably

associated


Input: Both colchicine and statin therapy may be associated with myopathy, which usually occurs after several months of therapy.

myopathy

colchicine and statin therapy

may

associated


Input: Cephalosporins are most likely associated with Vitamin K deficiency.

Cephalosporins

Vitamin K deficiency.

most likely

associated


Input: Embolia cutis medicamentosa following subcutaneous injection of glatiramer acetate.

Embolia cutis medicamentosa

subcutaneous injection of glatiramer acetate

following


Input: Reversible valproic acid-induced dementia was documented in a 21-year-old man with epilepsy who had a 3-year history of insidious progressive decline in global cognitive abilities documented by serial neuropsychological studies.

valproic acid

Reversible

dementia

a 21-year-old man with epilepsy who had a 3-year history of insidious progressive decline in global cognitive abilities

induced


Input: We describe the case of a 50-year-old woman with advanced non-small cell lung cancer who developed status epilepticus shortly after receiving cisplatin and gemcitabine chemotherapy.

a 50-year-old woman with advanced non-small cell lung cancer

status epilepticus

cisplatin and gemcitabine chemotherapy

developed


Input: Here, we report a case of angio-oedema associated with VRC therapy.

angio-oedema

VRC therapy

associated


Input: Multiple syncopal episodes started to occur during thalidomide treatment, and a Holter electrocardiogram showed multiple abnormalities, with an episode of sustained ventricular tachycardia.

during thalidomide treatment

Multiple syncopal episodes

and a Holter electrocardiogram showed multiple abnormalities, with an episode of sustained ventricular tachycardia

occur


Input: A 25-year-old woman sought medical attention because of iliocaval manifestations of retroperitoneal fibrosis while she was taking methysergide.

A 25-year-old woman

she

methysergide

iliocaval manifestations of retroperitoneal fibrosis

while


Input: Nodular scleritis following alendronate therapy.

Nodular scleritis

alendronate

following


Input: Thus, tolterodine was ineffective in both patients and was discontinued one to two days before the elevated INRs were determined during routine clinic visits.

tolterodine

both patients

ineffective

ineffective


Input: However, the use of lithium should be avoided with any patient who is purging, since it may exacerbate the loss of intracellular potassium, thereby increasing the risk of cardiac toxicity.

lithium

patient who is purging

loss of intracellular potassium

increasing the risk of cardiac toxicity

exacerbate


Input: Neurophysiological mechanisms which aid in elucidating the role of disulfiram in the etiology of catatonia are discussed.

disulfiram

catatonia

etiology