Input: A 7-year-old boy developed a severe unilateral grand mal seizure at the age of 5 years (phenobarbitone therapy); 1.5 years later valproate (2-propylpentanoic acid, VPA) was added to the therapy.

A 7-year-old boy developed a severe unilateral grand mal seizure

at the age of 5 years (phenobarbitone therapy); 1.5 years later valproate (2-propylpentanoic acid, VPA) was added to the therapy.

therapy


Input: We report the first case of rhabdomyolysis related to the administration of clarithromycin without concurrent use of other medications.

rhabdomyolysis

administration of clarithromycin without concurrent use of other medications

related to


Input: The authors report a further case of methimazole-associated liver damage and present a brief review of eleven previous cases found in the literature.

methimazole

liver damage

a further case

eleven previous cases

associated


Input: A 67-year-old patient, with primary polymyositis and without previous evidence of liver disease, developed clinical and biochemical features of severe cholestasis 3 months after initiation of azathioprine therapy.

A 67-year-old patient, with primary polymyositis and without previous evidence of liver disease

3 months after initiation of azathioprine

cholestasis

severe

developed


Input: Hypersensitivity reaction following chloramphenicol administration in a patient with typhoid fever.

a patient with typhoid fever

Hypersensitivity reaction

chloramphenicol

following


Input: Allergic and irritant contact dermatitis to calcipotriol.

contact dermatitis

calcipotriol

Allergic and irritant

to


Input: A 23-year-old woman with systemic lupus erythematosus had a severe hypersensitivity reaction to the drug ibuprofen.

hypersensitivity reaction

ibuprofen

A 23-year-old woman with systemic lupus erythematosus

severe

had


Input: We present the first case of WES in an infant born to a mother taking haloperidol during her pregnancy.

WES

haloperidol

an infant born to a mother

case


Input: Despite treatment with levofloxacin, acyclovir, and voriconazole, the patient developed high fevers.

levofloxacin, acyclovir, and voriconazole

high fevers

patient

developed


Input: The 5 patients had severe renovascular disease which might thus represent a significant risk factor in the development of captopril-induced acute renal failure.

The 5 patients had severe renovascular disease

captopril

acute renal failure

might

induced


Input: METHODS: Growth retardation was observed in six severely asthmatic children after introduction of high-dose fluticasone propionate treatment (dry powder).

six severely asthmatic children

Growth retardation

introduction of high-dose fluticasone propionate treatment (dry powder)

after


Input: The toxic effects of methotrexate included elevated liver transaminases (3/4), nausea (2/4), abdominal pain (2/4), bone pain (2/4), mild neutropenia (1/4), and mild pruritus (1/4).

methotrexate

toxic effects

elevated liver transaminases (3/4), nausea (2/4), abdominal pain (2/4), bone pain (2/4), mild neutropenia (1/4), and mild pruritus (1/4)

mild

of


Input: CONCLUSION: Zidovudine is well a known cause of anaemia and thus should be used with caution in the initiation of antiretroviral therapy.

Zidovudine

anaemia

cause


Input: A 60-yr-old woman, established on paroxetine for depression, underwent excision of a chest wall myxofibrosarcoma and chest wall reconstruction.

A 60-yr-old woman

depression

paroxetine

underwent excision of a chest wall myxofibrosarcoma and chest wall reconstruction

established


Input: Papilloedema and hepatic dysfunction apparently induced by perhexiline maleate (Pexid).

Papilloedema and hepatic dysfunction

perhexiline maleate (Pexid)

induced


Input: The volatile anesthetic halothane undergoes substantial biotransformation generating metabolites that mediate hepatotoxicity.

volatile anesthetic halothane

hepatotoxicity

mediate


Input: Case 4: A 61-year-old male alcoholic who remained completely abstinent while taking cyanamide for 3 years showed slight elevation of serum transaminases.

elevation of serum transaminases

61-year-old male alcoholic who remained completely abstinent

cyanamide for 3 years

taking


Input: These observations indicate that submassive hepatic necrosis may result from treatment with propylthiouracil and are consistent with the notion that sensitization mechanisms may be responsible for the hepatic injury induced by this drug.

submassive hepatic necrosis

propylthiouracil

result


Input: Two children with rheumatic fever developed anicteric hepatitis while on high-dose aspirin therapy.

Two children with rheumatic fever

anicteric hepatitis

high-dose aspirin

developed


Input: The authors describe valproate-induced hyperammonemia and mental status changes in an 88-year-old man, the first known reported case in an elderly patient.

an 88-year-old man

valproate

hyperammonemia and mental status changes

induced


Input: The mechanism of the decrease in plasma potassium induced by phosphate treatment was investigated in a 24-year-old hypertensive patient with hypophosphatemic osteomalacia, who was the youngest of four patients, belonging to a 23 number kindred of five generations.

decrease in plasma potassium

phosphate treatment

a 24-year-old hypertensive patient with hypophosphatemic osteomalacia, who was the youngest of four patients, belonging to a 23 number kindred of five generations

induced


Input: In the two cases, a combination of iloprost, a stable prostacyclin analogue (1 to 2 ng/kg/mn) with aspirin and dipyridamole was shown to inhibit ex vivo the heparin-induced platelet aggregation.

two cases

iloprost, a stable prostacyclin analogue (1 to 2 ng/kg/mn) with aspirin and dipyridamole

inhibit ex vivo

heparin

platelet aggregation

induced


Input: Adrenaline dacryolith: detection by ultrasound examination of the nasolacrimal duct.

dacryolith

Adrenaline

Adrenaline dacryolith


Input: Ten days after itraconazole was started, he developed paralytic ileus, neurogenic bladder, mild left ptosis, and absence of deep reflexes, with severe paralysis of the lower extremities and mild weakness of the upper extremities.

itraconazole

paralytic ileus, neurogenic bladder, mild left ptosis, and absence of deep reflexes, with severe paralysis of the lower extremities and mild weakness of the upper extremities

severe

mild

mild

developed


Input: OBJECTIVE: The aim of this paper is to describe a case of increased libido during fluvoxamine therapy.

fluvoxamine therapy.

increased libido

a case

during


Input: An 8-year-old child with familial Mediterranean fever exhibited signs of colchicine intoxication while receiving prophylactic doses of the drug.

An 8-year-old child

colchicine intoxication

prophylactic doses of the drug

exhibited


Input: Furthermore, the warfarin dose was again increased after discontinuation of ropinirole due to common gastrointestinal adverse effects.

the warfarin dose was again increased after discontinuation of ropinirole

due to


Input: Serotonin syndrome following metaxalone overdose and therapeutic use of a selective serotonin reuptake inhibitor.

Serotonin syndrome

metaxalone overdose

following


Input: The aim of this report is to describe the clinical and electroencephalographic findings seen in an elderly woman without previous history of seizures who developed a nonconvulsive generalized status epilepticus following acute withdrawal of lorazepam.

an elderly woman

nonconvulsive generalized status epilepticus

acute withdrawal of lorazepam

following


Input: We describe a patient with androgen-independent prostate cancer in whom PSA continued to decrease for a period of 15 months after flutamide withdrawal.

a patient with androgen-independent prostate cancer

PSA continued to decrease for a period of 15 months

flutamide withdrawal

after


Input: Acute renal failure following intravenous immunoglobulin therapy in a HIV-infected patient.

a HIV-infected patient

intravenous immunoglobulin therapy

Acute renal failure

following


Input: After a total of four doses of linezolid, the patient reported further discomfort.

a total of four doses of linezolid

the patient

further discomfort

reported


Input: Although moderate myelosuppression is not uncommonly seen in patients treated with lenalidomide, aplastic anemia has not previously been reported to be associated with this agent.

lenalidomide

aplastic anemia

not

associated


Input: This paper contributed to the identification of possible reactions in the oral cavity due to antiretroviral medication.

antiretroviral medication

reactions in the oral cavity

possible

due


Input: Persistent light reactivity from systemic quinine.

Persistent light reactivity

systemic quinine

from


Input: Based on the clinical status of the patient, it was suspected that several conditions contributed to the abnormal hypersensitivity to warfarin.

abnormal hypersensitivity

warfarin

the patient

suspected

to


Input: Treatment of APL in pregnancy is controversial as the use of ATRA has been questioned due to the teratogenic effect of retinoids.

retinoids

teratogenic effect

questioned

due


Input: Diazepam use by pregnant women can be associated with a later presentation of withdrawal symptoms in the neonate than that induced by the use of other drugs.

later presentation of withdrawal symptoms in the neonate

neonate

Diazepam

associated


Input: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.

A 65-year-old patient

chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram

following initiation of fentanyl

confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome

developed


Input: This case highlights rapid onset of adrenal insufficiency in a patient with CF-related liver disease treated briefly with a moderate CYP3A4 inhibitor.

a patient with CF-related liver disease

briefly with a moderate CYP3A4 inhibitor

rapid onset of adrenal insufficiency

onset


Input: The biochemistry of paracetamol hepatotoxicity is outlined and the increased susceptibility of alcoholic patients to the hepatotoxic effects of paracetamol is remarked upon.

alcoholic patients

hepatotoxic effects

paracetamol

remarked


Input: The newborn manifested a four day course of lethargy with unexplained high lithium levels in the adult toxic range.

four day course of lethargy with unexplained high lithium levels

lithium

newborn

manifested


Input: The occurrence of severe AIHA in CLL patients treated with fludarabine has been reported by several authors.

fludarabine

severe AIHA

CLL patients

severe

treated


Input: Corneal endothelial dysfunction associated with amantadine toxicity.

Corneal endothelial dysfunction

amantadine

associated


Input: We describe the development of cutaneous scleroderma in 3 patients coincident with the use of bleomycin in low cumulative doses of less than 100 U.

cutaneous scleroderma

3 patients

the use of bleomycin in low cumulative doses of less than 100 U

development


Input: This case suggests that sarcoidosis and pravastatin, two entities not frequently associated with myotonia, may interact in a synergistic manner to produce severe clinical myotonia in humans.

humans.

severe clinical myotonia

pravastatin

may

severe

interact


Input: Disopyramide-induced heart block.

Disopyramide

heart block

induced


Input: Telescoped digits of the hands and feet developed in a 69-year-old male with severe chronic tophaceous gout during allopurinol treatment.

a 69-year-old male with severe chronic tophaceous gout

Telescoped digits of the hands and feet

allopurinol treatment

developed


Input: CONCLUSIONS: Jet-injection devices might constitute a helpful method to treat those patients affected by severe human insulin-induced lipoatrophy.

Jet-injection devices

patients

might

treat

lipoatrophy

insulin

severe

induced


Input: We describe a relatively healthy, 9-year-old boy who developed a CA-MRSA skin and soft tissue infection and was treated with TMP-SMX.

TMP-SMX

a relatively healthy, 9-year-old boy

treated


Input: Recurrent septicemia with lethal outcome during and after cyclosporine therapy in severe ulcerative colitis.

cyclosporine

Recurrent septicemia with lethal outcome

lethal

after


Input: Amifostine-induced fever: case report and review of the literature.

Amifostine

fever

induced


Input: We report a patient who developed spontaneous splenic infarction after the use of sumatriptan for the treatment of migraine headache.

spontaneous splenic infarction

a patient

sumatriptan

developed


Input: Hepatotoxicity associated with 6-thioguanine therapy for Crohn's disease.

Hepatotoxicity

associated


Input: Neuropathy is a significant side effect of thalidomide therapy, which may limit its clinical use.

Neuropathy

thalidomide

significant

side effect


Input: A possible mechanism for focal neurological deficit in brain-damaged patients on phenytoin therapy is discussed.

phenytoin therapy

focal neurological deficit

brain-damaged patients

possible

mechanism


Input: Pulmonary toxicity with mefloquine.

Pulmonary toxicity

mefloquine

with


Input: Ciprofloxacin is one drug that has been reported to cause interstitial nephritis.

Ciprofloxacin

interstitial nephritis

cause


Input: Acute renal failure during lisinopril and losartan therapy for proteinuria.

Acute renal failure

lisinopril and losartan

during


Input: We present the first case of a patient with priapism after oral intake of the phenothiazine prothipendylhydrochloride.

a patient

priapism

oral intake of the phenothiazine prothipendylhydrochloride

after


Input: However, because diphenhydramine also exhibits type IA sodium channel blockade, cardiac toxicity is also possible.

diphenhydramine

also exhibits type IA sodium channel blockade, cardiac toxicity

also possible

because


Input: Ticlopidine-induced interstitial pulmonary disease: a case report.

Ticlopidine

interstitial pulmonary disease

induced


Input: Linezolid is a popular choice of antibiotic, especially for the treatment of orthopedic-related MRSA infections.

Linezolid

treatment


Input: We present a case of photo-onycholysis in a patient treated with doxycycline for acne vulgaris.

doxycycline

a patient

photo-onycholysis

treated


Input: Anticonvulsant hypersensitivity syndrome associated with Bellamine S, a therapy for menopausal symptoms.

Anticonvulsant hypersensitivity syndrome

Bellamine S, a therapy for menopausal symptoms

associated


Input: CASE SUMMARY: A 66-year-old white woman with a 10-year history of hypertension and bronchial asthma was switched from immediate-release verapamil hydrocloride 40 mg tid to sustained-release verapamil 240 mg/d po for better hypertension control.

A 66-year-old white woman with a 10-year history of hypertension and bronchial asthma

switched from immediate-release verapamil hydrocloride 40 mg tid to sustained-release verapamil 240 mg/d po

control


Input: Due to the severity of the rash, temozolomide was permanently discontinued.

temozolomide

rash

severity

Due


Input: Ovarian endometrioid carcinoma and endometriosis developing in a postmenopausal breast cancer patient during tamoxifen therapy: a case report and review of the literature.

Ovarian endometrioid carcinoma and endometriosis

a postmenopausal breast cancer patient

tamoxifen therapy

during


Input: CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.

central nervous system-related adverse effects, including headache, dizziness and insomnia

The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors

cause


Input: Terlipressin-induced ventricular arrhythmia.

Terlipressin

ventricular arrhythmia

induced


Input: CASE REPORT: We report a case of acute severe hepatitis resulting from erlotinib monotherapy in a patient with locally advanced pancreatic cancer.

acute severe hepatitis

erlotinib monotherapy

a patient with locally advanced pancreatic cancer

severe

resulting


Input: We highlight two instances of systemic allergic reaction, and discuss the potential side effects of local aprotinin injections in the orthopaedic setting as well as the evidence base for its use.

two instances

systemic allergic reaction

potential side effects

aprotinin

potential

of


Input: Acute pancreatitis associated with danazol treatment for endometriosis.

Acute pancreatitis

danazol treatment

Acute

associated


Input: CASE REPORT: We report the case of a 58 year old patient who, after 2 days of treatment with roxithromycin and betamethasone, manifested acute pancreatitis.

a 58 year old patient

after 2 days of treatment with roxithromycin

betamethasone

acute pancreatitis

manifested


Input: It should be recognized that ibuprofen may be associated with salt and water retention in the same fashion as previously described with phenylbutazone and indomethacin.

salt and water retention

ibuprofen

may

associated


Input: Gastric tumor, endometrial carcinoma and cervical adenocarcinoma in situ were detected after treatment with tamoxifen for breast cancer.

tamoxifen

Gastric tumor, endometrial carcinoma and cervical adenocarcinoma in situ

detected


Input: This therapy was also complicated by Warfarin-induced skin necrosis.

Warfarin

skin necrosis

induced


Input: Immobilization, while Paget's bone disease was present, and perhaps enhanced activation of dihydrotachysterol by rifampicin, could have led to increased calcium-release into the circulation.

dihydrotachysterol

increased calcium-release

enhanced

led


Input: Failure of plasmapheresis, corticosteroids and thionamides to ameliorate a case of protracted amiodarone-induced thyroiditis.

amiodarone

thyroiditis

induced

plasmapheresis, corticosteroids and thionamides

Failure

ameliorate


Input: Although neurotoxicity is a frequent complication of methotrexate therapy, fatal acute neurotoxicity is extremely uncommon, especially in adults.

neurotoxicity

methotrexate therapy

complication


Input: Intravenous sodium bicarbonate appears to be indicated prophylactically in combating the associated metabolic acidosis due to absorbed formic acid.

metabolic acidosis

absorbed formic acid

due

Intravenous sodium bicarbonate

appears to

combating


Input: Allopurinol-associated hand and foot deformities in chronic tophaceous gout.

Allopurinol

hand and foot deformities

associated


Input: The intramuscular challenge test with 25 UI of Miacalcic was positive with an immediate anaphylactic reaction.

25 UI of Miacalcic

immediate

anaphylactic reaction

reaction


Input: There are several documented case reports of serotonin toxicity when used with selective serotonin reuptake inhibitors.

selective serotonin reuptake inhibitors

serotonin toxicity

several documented case

reports


Input: A literature review revealed 83 other reported cases of rifampicin-induced renal insufficiency.

rifampicin

renal insufficiency

83 other reported cases

induced


Input: Complete regression of iatrogenic Kaposi's sarcoma due to corticosteroid treatment in a patient with tubercular pericarditis.

corticosteroid

a patient with tubercular pericarditis

regression


Input: DIAGNOSIS: Severe temozolomide-induced immunosuppression, exacerbated by corticosteroids, with profound T-cell lymphocytopenia and simultaneous opportunistic infections with Pneumocystis jiroveci pneumonia, brain abscess with Listeria monocytogenes, and cutaneous Kaposi's sarcoma.

temozolomide

exacerbated by corticosteroids

immunosuppression

T-cell lymphocytopenia

Pneumocystis jiroveci pneumonia

brain abscess with Listeria monocytogenes

cutaneous Kaposi's sarcoma

Severe

induced


Input: The use of cyclosporin has been associated with the development of cholelithiasis in transplant recipients.

cholelithiasis

transplant recipients

cyclosporin

development


Input: Rifampicin-induced adrenal insufficiency in the acquired immunodeficiency syndrome: difficulties in diagnosis and treatment.

Rifampicin

adrenal insufficiency

induced


Input: Bisphosphonate-related osteonecrosis of the skull base.

Bisphosphonate

osteonecrosis of the skull base

related


Input: Angioedema and dysphagia caused by contact allergy to inhaled budesonide.

contact allergy

Angioedema and dysphagia

budesonide

inhaled


Input: Emergence of Philadelphia positive chronic myeloid leukaemia during treatment with hydroxyurea for Philadelphia negative essential thrombocythaemia.

Emergence of Philadelphia positive chronic myeloid leukaemia

hydroxyurea

treatment


Input: Ciprofloxacin greatly increases concentrations and hypotensive effect of tizanidine by inhibiting its cytochrome P450 1A2-mediated presystemic metabolism.

Ciprofloxacin

concentrations and hypotensive effect of tizanidine

increases


Input: 2-CdA induces lymphocytopenia, which may explain the improvement in this patient's psoriasis.

patient's psoriasis

lymphocytopenia

may

induces


Input: There is a dose-effect relationship between doxorubicin and the incidence of symptomatic cardiac failure.

doxorubicin

symptomatic cardiac failure

relationship


Input: These are the first reported patients to show mfERG abnormalities that correspond to bitemporal visual field defects and add to the growing evidence that ethambutol damages the retina.

ethambutol

damages the retina

evidence


Input: Two days after administration of Kalimate enema, he had profuse hematochezia, and a sigmoidoscopy showed diffuse colonic mucosal necrosis in the rectum and sigmoid colon.

Two days after administration of Kalimate enema

he

profuse hematochezia

diffuse colonic mucosal necrosis in the rectum

after


Input: Conventional and diffusion-weighted MRI findings of methotrexate related sub-acute neurotoxicity.

methotrexate

sub-acute neurotoxicity

related


Input: Scleromyxedema in a patient with multiple sclerosis and monoclonal gammopathy on interferon beta-1a.

interferon beta-1a

Scleromyxedema

a patient with multiple sclerosis and monoclonal gammopathy

on


Input: The literature search revealed 22 cases of hypersensitivity reaction to cyclosporine.

22 cases

hypersensitivity reaction

cyclosporine

to


Input: The presence of a lymphocyte alveolitis with a predominance of CD4+ T cells in 3 RA patients and CD8+ T cells with a concomitant increase in neutrophils in another case suggests that immunologically mediated reactions may be one damage mechanism in MTX-induced pneumonitis.

MTX

a lymphocyte alveolitis with a predominance of CD4+ T cells

pneumonitis

CD8+ T cells with a concomitant increase in neutrophils

3 RA patients

induced


Input: The authors report two cases of delayed elimination of methotrexate in patients receiving ciprofloxacin, with severe toxicity.

delayed elimination

methotrexate

patients receiving ciprofloxacin

severe

of


Input: Severe acute encephalopathy following inadvertent intrathecal doxorubicin administration.

Severe acute encephalopathy

intrathecal doxorubicin administration

Severe

following


Input: Porcine factor VIII (pFVIII), which is used to control bleeding in patients with congenital or acquired haemophilia who have high-titre neutralizing antibodies to human FVIII, is not known to increase the risk of arterial or venous thrombosis.

risk of arterial or venous thrombosis.

Porcine factor VIII (pFVIII)

patients with congenital or acquired haemophilia who have high-titre neutralizing antibodies to human FVIII

risk

not

increase


Input: In all the patients, pellagra symptoms appeared during isoniazid therapy.

all the patients

pellagra symptoms

isoniazid therapy

appeared


Input: Fatal gemcitabine-induced pulmonary toxicity in metastatic gallbladder adenocarcinoma.

gemcitabine

pulmonary toxicity

Fatal

induced


Input: Olanzapine-induced hyperglycaemic coma and neuroleptic malignant syndrome: case report and review of literature.

Olanzapine

hyperglycaemic coma and neuroleptic malignant syndrome

induced


Input: Neurologic symptoms resolved after stopping CAP for 4 weeks in Patient A, with no recurrence after reinitiating CAP alone at 2000 mg/m2.

Neurologic symptoms resolved

stopping CAP for 4 weeks

after


Input: OBJECTIVE: To report a case of serotonin syndrome associated with interaction between fentanyl and citalopram, as evidenced by medication history, clinical features and reversal following discontinuation of fentanyl.

a case

serotonin syndrome

fentanyl and citalopram

interaction


Input: We report (to our knowledge, for the first time in a child) the emergence of psychosis in a 12-year old white girl with an increased efavirenz concentration and heterozygous gene polymorphism of the CYP2B6-G516T.

psychosis

a 12-year old white girl

heterozygous gene polymorphism of the CYP2B6-G516T

increased efavirenz concentration

emergence


Input: Severe erythroderma as a complication of continuous epoprostenol therapy.

Severe erythroderma

continuous epoprostenol

Severe

complication


Input: FDE from cephalosporins has been rarely reported, and to the best of our knowledge there is no published report of ceftriaxone-induced FDE in the literature.

FDE

cephalosporins

from

ceftriaxone

FDE

induced


Input: CASE SUMMARY: A 58-year-old white woman developed fulminant liver failure while being treated with the macrolide antibiotic clarithromycin for pneumonia.

A 58-year-old white woman

fulminant liver failure

macrolide antibiotic clarithromycin for pneumonia

developed


Input: CONCLUSIONS: Marked elevation of serum CK may be a possible complication of olanzapine therapy.

Marked elevation of serum CK

olanzapine therapy

complication


Input: OBJECTIVE: To describe a case of severe skin necrosis resulting from peripheral intravenous administration of low-dose vasopressin in a patient with catecholamine-resistant septic shock.

a patient with catecholamine-resistant septic shock

skin necrosis

peripheral intravenous administration of low-dose vasopressin

severe

resulting


Input: Although the essential cause of PV is unclear, its onset has occasionally been associated with drug therapy, in particular penicillamine.

penicillamine

PV

associated


Input: Recurrent hypotension immediately after seizures in nortriptyline overdose.

Recurrent hypotension immediately after seizures

nortriptyline overdose

in


Input: We report a patient with recurrent, increasingly severe episodes of PPE, ultimately complicated by a severe bullous eruption, following successive cycles of high-dose cytarabine for the treatment of acute lymphoblastic leukaemia.

a patient

recurrent, increasingly severe episodes of PPE, ultimately complicated by a severe bullous eruption

cycles of high-dose cytarabine for the treatment of acute lymphoblastic leukaemia

severe

following


Input: Intravenous diazepam exacerbated the seizures.

seizures

Intravenous diazepam

exacerbated


Input: After nine previous uncomplicated cycles she developed severe anaphylaxis to cisplatin.

she

severe anaphylaxis

cisplatin

developed


Input: Cefuroxime-induced acute renal failure.

Cefuroxime

acute renal failure

induced


Input: We describe the clinical and liver biopsy morphologic features for 4 patients with minocycline-induced autoimmune hepatitis (group 1).

4 patients

minocycline

autoimmune hepatitis

induced


Input: Intravitreal triamcinolone acetonide for persisting cystoid macular edema after penetrating keratoplasty.

ntravitreal triamcinolone acetonide

for

penetrating keratoplasty

persisting cystoid macular edema

persisting

after


Input: We report a case of a 29-year-old liver transplant patient who suffered liver injury most likely induced by drug interaction between capecitabine and warfarin.

a 29-year-old liver transplant patient

liver injury

drug interaction between capecitabine and warfarin

most likely

induced


Input: DISCUSSION: Patients with 5-FU-induced ectropion experience tender, red, scaled lids, making contact lens wear difficult.

ectropion

tender, red, scaled lids

Patients with 5-FU-induced ectropion

induced


Input: Restless legs syndrome may thus be an adverse effect of IFN alpha treatment.

IFN alpha treatment.

Restless legs syndrome

may

adverse effect


Input: Treatment of chronic hepatitis C with interferon alpha (IFN-alpha) is relatively contraindicated in patients with psychiatric disorders because of possible severe psychiatric side effects.

interferon alpha (IFN-alpha)

patients with psychiatric disorders

possible severe psychiatric side effects

contraindicated


Input: METHODS: We report a patient who had an anaphylactic reaction during the intravenous infusion of cyclosporine.

a patient

anaphylactic reaction

intravenous infusion of cyclosporine

during


Input: Gabapentin toxicity in renal failure: the importance of dose adjustment.

Gabapentin

renal failure

toxicity


Input: We describe a case of a man treated with an EGFR-inhibitor (erlotinib) for a cell lung cancer who developed skin manifestations localized in an uncommon area and with an atypical evolution.

a man

EGFR-inhibitor (erlotinib)

skin manifestations localized in an uncommon area and with an atypical evolution

developed


Input: We describe a case of clozapine-induced seizures in a patient with treatment-resistant schizophrenia.

clozapine

seizures

a patient with treatment-resistant schizophrenia

induced


Input: Two fatal cases of poisoning by paracetamol are described.

paracetamol

Two fatal cases

poisoning

fatal

by


Input: The neurotoxicity seen with HDARAC is dose-related and has occurred in up to 60 percent of treated patients.

neurotoxicity

HDARAC

60 percent of treated patients

related


Input: The HIV protease inhibitor indinavir may cause nephrolithiasis and interstitial nephritis.

HIV protease inhibitor indinavir

nephrolithiasis and interstitial nephritis

may

cause


Input: BACKGROUND: Colchicine has a known adverse effect on wound healing through its inhibitory effect on tubulin-dependent cell functions and through collagenase activation.

Colchicine

wound healing

adverse effect


Input: Pneumocystis carinii pneumonia as a complication of methotrexate treatment of asthma.

Pneumocystis carinii pneumonia

methotrexate

complication


Input: 2-CdA typically causes a long-lasting state of immunodeficiency and the profound influence of this drug on the immune system has raised questions concerning the emergence of secondary neoplasms after its use.

a long-lasting state of immunodeficiency

emergence of secondary neoplasms after its use

questions

causes


Input: CONCLUSIONS: Topiramate may be associated with ciliochoroidal effusion with forward displacement of the lens-iris diaphragm and anterior chamber shallowing, resulting in acute myopia and angle-closure glaucoma.

Topiramate

acute myopia and angle-closure glaucoma

resulting


Input: Increased awareness is needed on the possible occurrence of LPD resembling gastric cancer in rheumatoid arthritis patients treated with MTX.

LPD

rheumatoid arthritis patients

MTX

occurrence


Input: A dapsone hypersensitivity syndrome, consisting of fever, headache, nausea, vomiting, lymphadenopathy, hepatitis, hemolysis, leukopenia, and mononucleosis, has been described in patients treated with the drug for leprosy.

dapsone

hypersensitivity syndrome, consisting of fever, headache, nausea, vomiting, lymphadenopathy, hepatitis, hemolysis, leukopenia, and mononucleosis

patients

treated


Input: CONCLUSIONS: Intravitreal injection of triamcinolone acetonide may be an additional tool in the treatment of therapy-resistant cystoid macular edema after penetrating keratoplasty.

Intravitreal injection of triamcinolone acetonide

treatment


Input: Since its FDA approval in 2002, there are no known citations of ezetimibe-induced pancreatitis.

ezetimibe

pancreatitis

no

induced


Input: Acute acoustic nerve palsy associated with vincristine therapy.

vincristine therapy

Acute acoustic nerve palsy

associated


Input: Review of all reported cases of the use of ATRA in pregnancy revealed no serious adverse outcomes or congenital anomalies although only very few cases had exposure in the first trimester.

ATRA

in pregnancy

adverse outcomes or congenital anomalies

no

revealed


Input: The first patient was a 57-year-old man with HIV and bipolar disease who developed rapid and severe weight gain when quetiapine was added to a stable atazanavir-ritonavir-based antiretroviral regimen.

a 57-year-old man with HIV and bipolar disease

rapid and severe weight gain

quetiapine was added to a stable atazanavir-ritonavir-based antiretroviral regimen

developed


Input: A 43-year-old woman with multiple sclerosis (MS) had nephrotic syndrome 21 months after starting treatment with interferon (IFN)-beta-1b (subcutaneous administration).

A 43-year-old woman with multiple sclerosis (MS)

nephrotic syndrome

21 months after starting treatment with interferon (IFN)-beta-1b (subcutaneous administration)

had


Input: RESULTS: An 81-year-old man with a history of neoplasies of the colon and prostate and anticoagulant treatment was referred for treatment of an ocular surface neoplasia on his left eye.

anticoagulant

an ocular surface neoplasia on his left eye

An 81-year-old man with a history of neoplasies of the colon and prostate

referred


Input: CONCLUSION: The present findings suggest that: (i) amantadine probably exerts its anti-dyskinetic effect by acting on the "indirect" pathway; (ii) the pathophysiological mechanisms of subthalamotomy induced dyskinesias may differ from those involved in L-dopa induced dyskinesias; (iii) dyskinesias induced by STN surgery resolve spontaneously as compensatory mechanisms develop.

amantadine

anti-dyskinetic effect

probably

exerts


Input: We report a case of a previously healthy, postmenopausal woman who developed anticonvulsant hypersensitivity syndrome while taking Bellamine S (belladonna alkaloids; ergotamine; phenobarbital) for hot flashes.

a previously healthy, postmenopausal woman

anticonvulsant hypersensitivity syndrome

Bellamine S (belladonna alkaloids; ergotamine; phenobarbital)

developed


Input: Skin rash began after 2 weeks of treatment, and signs of hepatocellular failure developed 3 weeks after phenobarbital had been started.

Skin rash

hepatocellular failure

phenobarbital

developed


Input: Ceftriaxone was approved in 1997 for the treatment of otitis media despite previous studies that documented an association of ceftriaxone with elevated hepato-biliary enzymes and transient biliary stasis.

elevated hepato-biliary enzymes and transient biliary stasis

ceftriaxone

association of


Input: A rare case of advanced ovarian carcinoma who developed difficulty walking 25 days after treatment with weekly paclitaxel.

difficulty walking

25 days after treatment with weekly paclitaxel

A rare case of advanced ovarian carcinoma

developed


Input: We report a case of cough following the administration of quinapril, with complete resolution after changing to the alternative ACE inhibitor fosinopril in a patient with essential hypertension.

cough

the administration of quinapril

patient with essential hypertension

following


Input: Liver disease induced by perhexiline maleate.

Liver disease

perhexiline maleate

induced by


Input: OBJECTIVE: To report the occurrence of anaphylactoid reactions to intraperitoneal cisplatin in 3 patients.

intraperitoneal cisplatin

3 patients.

anaphylactoid reactions

to


Input: In a female with acute lymphoblastic leukemia, inadvertent doxorubicin administration intrathecally caused severe, life-threatening, acute encephalopathy with high-pressure hydrocephalus.

female with acute lymphoblastic leukemia

severe, life-threatening, acute encephalopathy with high-pressure hydrocephalus

inadvertent doxorubicin administration intrathecally

severe, life-threatening, acute

caused


Input: These skin lesions may be induced or worsened during antiviral therapy with interferon-alpha (IFN).

skin lesions

antiviral therapy with interferon-alpha (IFN)

may

induced


Input: Clinicians should be aware of the proepileptogenic effect of venlafaxine and trimipramine at therapeutic doses and that this combination may eventually increase the risk of seizures.

increase the risk of seizures

venlafaxine and trimipramine at therapeutic doses

may

eventually


Input: We report the case of a 43-year-old man with ITP refractory to steroids and intravenous immunoglobulin who developed acute respiratory distress syndrome (ARDS) after a single infusion of rituximab.

single infusion of rituximab

acute respiratory distress syndrome (ARDS)

the case of a 43-year-old man with ITP refractory to steroids and intravenous immunoglobulin

developed


Input: She had been prescribed two mood stabilizers and suffered from anticholinergic adverse effects and the movement disorder tardive dyskinesia (TD).

prescribed two mood stabilizers

anticholinergic adverse effects and the movement disorder tardive dyskinesia (TD)

suffered from


Input: CASE REPORT: We describe here a case of a 60 year old female that experienced a relapse of symptomatic hyperlactatemia after being switched from stavudine to zidovudine and how the case was managed at the Infectious Diseases Institute, Kampala, Uganda.

a case of a 60 year old female

relapse of symptomatic hyperlactatemia

switched from stavudine to zidovudine

after


Input: This report describes two patients who developed acute myelocytic leukemia only after exposure to cyclophosphamide, methotrexate, and 5-fluorouracil adjuvant therapy.

two patients

acute myelocytic leukemia

exposure to cyclophosphamide, methotrexate, and 5-fluorouracil adjuvant therapy

developed


Input: Reversible corneal keratinization following trabeculectomy and treatment with 5-fluorouracil.

Reversible corneal keratinization

following


Input: CASE: We report a case of a woman with severe human insulin-induced lipoatrophy who has been treated exclusively with recombinant DNA human insulin since the onset of IDDM.

recombinant DNA human insulin

woman

severe human insulin-induced lipoatrophy

severe

treated


Input: METHOD: Case analysis of a poly-drug overdose (venlafaxine, topiramate, divalproex sodium, risperidone, and carbamazepine) presenting with mixed SS/NMS features and whose clinical management suggests a practical algorithm for treatment of undifferentiated SS/NMS in critical care settings.

a poly-drug overdose (venlafaxine, topiramate, divalproex sodium, risperidone, and carbamazepine)

mixed SS/NMS features

presenting


Input: Hyperpigmentation is one of the cutaneous side effects of chemotherapautic agents, but it is usually accepted as a cosmetic problem.

Hyperpigmentation

chemotherapautic agents

of


Input: Pancreatitis is a very rare adverse effect associated with the use of amiodarone, and only four cases of amiodarone-induced pancreatitis have been reported in literature.

pancreatitis

amiodarone

four cases

induced


Input: The latter form (Macrodantin) is reported to engender less gastrointestinal intolerance but it can produce the same adverse effects as the conventional form--liver damage, acute and chronic pulmonary reactions, peripheral neuropathy, blood dyscrasias and allergic reactions--and does so just as rapidly and floridly; one such case is reported here.

Macrodantin

less gastrointestinal intolerance

liver damage, acute and chronic pulmonary reactions, peripheral neuropathy, blood dyscrasias and allergic reactions

one such case

can

adverse effects


Input: CASE REPORT: A 29-year-old black man, HIV-infected since 1996, began highly active antiretroviral therapy (HAART) with zidovudine, lamivudine, and indinavir.

A 29-year-old black man, HIV-infected since 1996

highly active antiretroviral therapy (HAART) with zidovudine, lamivudine, and indinavir

began


Input: METHOD: The authors followed a patient with chronic HCV who received interferon and ribavirin and who developed hallucinations ultimately requiring psychiatric hospitalization.

a patient with chronic HCV

interferon and ribavirin

hallucinations

developed


Input: This case of linezolid-associated acute interstitial nephritis within the context of a drug rash with eosinophilia and systemic symptoms (DRESS) syndrome in a patient treated with linezolid raises concerns about the presumed renal safety of this drug.

acute interstitial nephritis within the context of a drug rash with eosinophilia and systemic symptoms (DRESS) syndrome

linezolid

associated


Input: Easily reversible hypoxemia and hypotension induced by nimodipine.

hypoxemia and hypotension

nimodipine

Easily reversible

induced


Input: Adverse effects of amiodarone including pulmonary toxicity, hepatotoxicity, aggravation of arrhythmia, and thyroid diseases are well understood.

amiodarone

pulmonary toxicity, hepatotoxicity, aggravation of arrhythmia, and thyroid diseases

including


Input: Chronic photosensitivity associated with hydrochlorothiazide ingestion occurred in four patients.

Chronic photosensitivity

four patients

hydrochlorothiazide ingestion

associated


Input: Chlorambucil central nervous toxicity: a significant side effect of chlorambucil therapy in childhood nephrotic syndrome.

Chlorambucil

central nervous toxicity

side effect


Input: The mechanism of action of this centrally acting muscle relaxant is unknown; however, the observation of serotonin syndrome in patients with metaxalone overdose suggests a role in the serotonergic pathway.

centrally acting muscle relaxant

metaxalone overdose

serotonin syndrome

patients

in


Input: In general, angiotensin converting enzyme (ACE) inhibitors should be discontinued in pregnancy, as they can induce an ACE fetopathy.

ACE fetopathy

angiotensin converting enzyme (ACE) inhibitors

pregnancy

can

induce


Input: Of 371 patients treated with 8MOP, three (0.8%) developed an acute dermatitis in the PUVA-treated areas.

acute dermatitis

Of 371 patients

three (0.8%)

treated with 8MOP

developed


Input: There is a putative role of liothyronine administration in precipitating or activating hyperthyroidism.

hyperthyroidism

liothyronine

precipitating or activating


Input: Neutropenic colitis during standard dose combination chemotherapy with nedaplatin and irinotecan for testicular cancer.

Neutropenic colitis

standard dose combination chemotherapy with nedaplatin and irinotecan for testicular cancer

during


Input: Brain metastases are a frequent finding in patients with advanced non-small cell lung cancer and concomitant administration of antiepileptic and chemotherapeutic drugs or epidermal growth factor receptor (EGFR) inhibitor is necessary in many cases.

concomitant administration of antiepileptic and chemotherapeutic drugs or epidermal growth factor receptor (EGFR) inhibitor

patients with advanced non-small cell lung cancer

necessary


Input: A female patient with HER2 positive, metastatic breast cancer presented with pulmonary infiltrates, and a plural effusion dyspnoea after several months of trastuzumab treatment.

A female patient with HER2 positive, metastatic breast cancer

trastuzumab

pulmonary infiltrates, and a plural effusion dyspnoea

presented


Input: Thrombocytosis under ciprofloxacin and tazobactam/piperacillin.

Thrombocytosis

ciprofloxacin and tazobactam/piperacillin

under


Input: Quinine and its isomer quinidine are well-known causes of iatrogenic hypoglycaemia, due to excessive insulin secretion.

Quinine and its isomer quinidine

iatrogenic hypoglycaemia, due to excessive insulin secretion

causes


Input: Therefore, it is reasonable to conclude that: 1) 2-CdA can induce durable complete remission in MCD patients but unfortunately it cannot cure the disease; 2) the possibility that 2-CdA may accelerate the transformation of MCD to NHL cannot be ruled out.

durable complete remission

can

induce

the transformation of MCD to NHL

possibility

accelerate


Input: Hyperammonemia secondary to valproic acid as a cause of lethargy in a postictal patient.

Hyperammonemia

valproic acid

a postictal patient

cause


Input: OBJECTIVE: To report on the possible development of serotonin syndrome in a patient receiving clomipramine after clozapine was withdrawn from the treatment regimen.

clomipramine

serotonin syndrome

patient

possible

receiving


Input: Fatal ventricular fibrillation after treatment with digoxin in a 27-year-old man with mitral leaflet prolapse syndrome.

digoxin

a 27-year-old man with mitral leaflet prolapse syndrome

Fatal ventricular fibrillation

Fatal

after


Input: Clostridium difficile colitis associated with cisplatin-based chemotherapy in ovarian cancer patients.

Clostridium difficile colitis

cisplatin-based chemotherapy

ovarian cancer patients.

associated


Input: Lithium-induced Creutzfeldt-Jakob syndrome.

Lithium

Creutzfeldt-Jakob syndrome

induced


Input: It is concluded that simultaneous administration of ciprofloxacin and tazobactam/piperacillin may cause marked thrombocytosis.

simultaneous administration of ciprofloxacin and tazobactam/piperacillin

marked thrombocytosis

may

cause


Input: Alone or in combination with corticosteroids, cyclosporine is an effective drug of choice for the resistant patients.

Alone or in combination with corticosteroids, cyclosporine

resistant patients

is


Input: Bull's-eye maculopathy associated with quinacrine therapy for malaria.

Bull's-eye maculopathy

quinacrine

associated


Input: Physicians should be aware that indinavir nephrolithiasis may cause papillary necrosis.

indinavir nephrolithiasis

papillary necrosis

may

cause


Input: Following the institution of intravenous therapy with acyclovir, the patient developed fever, hemoptysis, and a pleural friction rub.

acyclovir

the patient

fever, hemoptysis, and a pleural friction rub

developed


Input: Due to discomfort, diplopia and lagophthalmos, the haematoma necessitated suspension of warfarin therapy and a surgical evacuation.

discomfort, diplopia and lagophthalmos, the haematoma

warfarin therapy and a surgical evacuation

Due to


Input: Acute dystonia with thalamic and brainstem lesions after initial penicillamine treatment in Wilson's disease.

Acute dystonia with thalamic and brainstem lesions

penicillamine

after


Input: Fatal agranulocytosis in an Indian male receiving 100mg of dapsone daily, hospitalized for mid-borderline leprosy in type I reaction with triple nerve paralysis is reported.

mid-borderline leprosy in type I reaction with triple nerve paralysis

Fatal agranulocytosis

100mg of dapsone daily

Fatal

receiving


Input: The authors presented a case of pulmonary hypertension during lithium therapy, while she has been on lithium for 6 years.

pulmonary hypertension

lithium therapy

she

during


Input: BACKGROUND: Oxaliplatin is a platinum derivative, which is used in the treatment of colorectal cancer.

Oxaliplatin is a platinum derivative

treatment


Input: After having received gemcitabine on day 1 of the second course, the patient developed dry cough, subfebrile temperatures and dyspnea within 48 h.

received gemcitabine on day 1 of the second course

the patient

dry cough, subfebrile temperatures and dyspnea within 48 h

developed


Input: As linezolid has been shown to have hematologic side effects, blood count monitoring is recommended in patients receiving this drug for long-term therapy.

linezolid

hematologic side effects

have


Input: The role of Adriamycin in the production of cardiotoxicity is reviewed.

Adriamycin

cardiotoxicity

production


Input: He began taking propafenone only 6 days prior to admission because of uncontrolled atrial fibrillation and symptoms of fatigue.

propafenone

taking


Input: A 53-year-old man developed NMS without rigidity while taking olanzapine.

A 53-year-old man

NMS without rigidity

olanzapine

developed


Input: We report on a 14-year-old boy with severe haemophilia A who developed a portal vein thrombosis during continuous infusion of F VIII.

a 14-year-old boy with severe haemophilia A

a portal vein thrombosis

continuous infusion of F VIII

developed


Input: Suxamethonium apnoea terminated with commercial serumcholinesterase.

Suxamethonium apnoea

commercial serumcholinesterase

terminated


Input: Fatal multiple drug intoxication following acute sertraline use.

multiple drug intoxication

acute sertraline use

Fatal

following


Input: OBSERVATIONS: We observed aggravation and spreading of a psoriatic plaque when treated topically with the toll-like receptor (TLR) 7 agonist imiquimod.

aggravation and spreading of a psoriatic plaque

the toll-like receptor (TLR) 7 agonist imiquimod

observed


Input: Hypercalcemia in an AIDS patient treated with growth hormone.

Hypercalcemia

an AIDS patient

growth hormone

with


Input: Significant drug interaction: phenytoin toxicity due to erlotinib.

phenytoin toxicity

erlotinib

due


Input: A pharmacokinetic interaction between the selective serotonin reuptake inhibitor citalopram and a tricyclic antidepressant, clomipramine, was noted in a patient treated for major depression and obsessive-compulsive disorder.

A pharmacokinetic interaction

the selective serotonin reuptake inhibitor citalopram and a tricyclic antidepressant, clomipramine

a patient treated for major depression and obsessive-compulsive disorder

interaction


Input: They continued to rise for five more days before salicylate hepatotoxicity was suspected.

salicylate

hepatotoxicity

suspected

suspected


Input: The occurrence of neuromuscular blockade and the resulting potentiation of muscle relaxants during magnesium sulfate (MgSO4) administration is well known.

neuromuscular blockade

potentiation of muscle relaxants

magnesium sulfate

during


Input: Based on these findings, the patient was diagnosed with diabetes insipidus secondary to lithium therapy and was treated successfully with amiloride.

diabetes insipidus

lithium

diagnosed

successfully

amiloride

treated


Input: Gabapentin-induced mood changes with hypomanic features in adults.

adults

mood changes with hypomanic features

Gabapentin

induced


Input: Drug induced polymyositis secondary to leuprolide acetate (Lupron) therapy for prostate carcinoma.

leuprolide acetate (Lupron) therapy

Drug induced polymyositis

secondary to


Input: Incomplete posterior hyaloid detachment after intravitreal pegaptanib injection in diabetic macular edema.

Incomplete posterior hyaloid detachment

ntravitreal pegaptanib injection in diabetic macular edema

after


Input: This paper reports a case of fatal perhexiline maleate liver injury.

perhexiline maleate

liver injury

fatal

a case of


Input: During the second hospitalization it is possible that antipsychotic treatment combined with an antidepressant caused akathisia or there were symptoms of agitated depression and akathisia present at the same time, which is very difficult to determine in everyday clinical practice.

antipsychotic treatment combined with an antidepressant

akathisia

possible

caused


Input: OBJECTIVES: To describe the presentation and treatment of acute isoniazid (INH) neurotoxicity appearing at an inner-city municipal hospital.

isoniazid (INH) neurotoxicity

isoniazid (INH)

neurotoxicity


Input: Clozapine, an atypical antipsychotic, can be toxic at doses 4 times a moderate dose.

doses 4 times a moderate dose

Clozapine

toxic

be


Input: This article presents a 3(1/2)-year-old child on valproic acid, lamotrigine, and phenytoin who developed simultaneous hepatotoxicity and bone marrow toxicity during a parainfluenza virus type 3 infection.

a 3(1/2)-year-old child

valproic acid, lamotrigine, and phenytoin

simultaneous hepatotoxicity and bone marrow toxicity

developed


Input: Reversible cholestasis with bile duct injury following azathioprine therapy.

Reversible cholestasis with bile duct injury

azathioprine

following


Input: The authors report five cases of tremor related to itraconazole therapy, which occurred within 1-12 months of initiating treatment and resolved gradually following itraconazole withdrawal.

tremor

itraconazole therapy,

related


Input: OBJECTIVE: To report a case of phenolphthalein-induced toxic epidermal necrolysis (TEN) in a patient maintained on several other medications more commonly known to be associated with TEN.

toxic epidermal necrolysis (TEN)

a case of

a patient

phenolphthalein

maintained on several other medications more commonly known to be associated with TEN

induced


Input: Clinical symptoms and leukopenia normalized after discontinuation of CBZ and administration of prednisolone at 40 mg.

Clinical symptoms and leukopenia normalized

discontinuation of CBZ and administration of prednisolone at 40 mg

normalized


Input: A patient with alcoholic cerebellar degeneration had periodic alternating nystagmus during a period of phenytoin intoxication.

A patient with alcoholic cerebellar degeneration

phenytoin

periodic alternating nystagmus

during


Input: Extensive forearm deep venous thrombosis following a severe infliximab infusion reaction.

Extensive forearm deep venous thrombosis

nfusion reaction

infliximab

severe

following


Input: Severe acidosis from acetazolamide in a diabetic patient.

a diabetic patient

Severe acidosis

acetazolamide

Severe

from


Input: CONCLUSIONS: Clinicians should be aware that Crohn's disease is a potential novel adverse drug effect of Copaxone.

Crohn's disease

Copaxone

potential

effect


Input: ADR induced by drug treatment can be a side effect of treatment with antipsychotic drugs and other drugs; however, there have been no reports of lamivudine-induced ADR in the English literature.

lamivudine

ADR

no

induced


Input: CONCLUSIONS: The piloerection observed after the replacement of fluvoxamine with milnacipran in this patient appears to have been due to an increase in the alpha(1)-adrenoceptor occupancy by endogenous norepinephrine induced by milnacipran.

milnacipran

an increase in the alpha(1)-adrenoceptor occupancy by endogenous norepinephrine

induced

piloerection

this patient

milnacipran

observed


Input: Serotonin syndrome from the interaction of cyclobenzaprine with other serotoninergic drugs.

Serotonin syndrome

interaction of cyclobenzaprine with other serotoninergic drugs

from


Input: However, a recent post-marketing survey in Japan revealed that interstitial pneumonia occurred in 4 among approximately 2 000 Japanese patients treated with sorafenib.

4 among approximately 2 000 Japanese patients

sorafenib

interstitial pneumonia

occurred


Input: The other patient developed transient intraoperative hypertension immediately after inadvertent submucosal injection of concentrated epinephrine.

transient intraoperative hypertension immediately

inadvertent submucosal injection of concentrated epinephrine

The other patient

developed


Input: This experience supports the hypothesis that heparin can be readministered early to patients with heparin-associated thrombocytopenia and thrombosis, provided antiplatelet therapy is given.

heparin

antiplatelet therapy is given

hypothesis

readministered

heparin

thrombocytopenia and thrombosis

associated


Input: Pneumonitis with pleural and pericardial effusion and neuropathy during amiodarone therapy.

Pneumonitis with pleural and pericardial effusion and neuropathy

amiodarone therapy

during


Input: We report a case of interstitial pneumonitis induced by bicalutamide and/or leuprorelin acetate given as therapy for prostate cancer, in which the pneumonitis was successfully managed by steroid treatment.

interstitial pneumonitis

a case

bicalutamide and/or leuprorelin acetate given as therapy for prostate cancer

induced


Input: For those patients with a history of NMS, or even of isolated serum CK elevation during antipsychotic therapy, follow-up should be stricter.

patients with a history of NMS

isolated serum CK elevation

antipsychotic therapy

during


Input: Children with acute lymphoblastic leukemia (ALL), treated with L-asparaginase are at risk for cerebral thrombosis or hemorrhage because of coagulation protein deficiencies.

L-asparaginase

Children with acute lymphoblastic leukemia (ALL)

cerebral thrombosis or hemorrhage

coagulation protein deficiencies

risk


Input: Two of the five patients who worsened motorically also developed encephalopathy during risperidone treatment; the encephalopathy resolved when the patients were switched to clozapine treatment.

Two of the five patients who worsened motorically

encephalopathy

risperidone treatment

developed

Two of the five patients who worsened motorically

switched to clozapine treatment

resolved


Input: The effectiveness of sugammadex in reversing rocuronium-induced neuromuscular blockade (NMB) in the presence of drugs that may potentiate NMB remains to be fully established.

rocuronium

neuromuscular blockade (NMB)

induced

sugammadex

in the presence of drugs that may potentiate NMB

remains to be fully established

reversing


Input: Dexamethasone treatment of amiodarone-induced thyrotoxicosis (AIT) with or without persistent administration of the drug.

amiodarone

thyrotoxicosis (AIT)

induced


Input: Acyclovir neurotoxicity: clinical experience and review of the literature.

Acyclovir

neurotoxicity

experience


Input: Inadvertent exaggerated anticoagulation following use of bismuth subsalicylate in an enterally fed patient receiving warfarin therapy.

Inadvertent exaggerated anticoagulation

bismuth subsalicylate

warfarin therapy

an enterally fed patient

following


Input: We report the specifics of 12 cases of severe hypertension after the intraoperative use of topical phenylephrine, submucosal epinephrine, or both.

12 cases

intraoperative use of topical phenylephrine, submucosal epinephrine, or both

hypertension

severe

after


Input: The patient experienced muscle twitches, tremulousness, and anxiety on day 17 of foscarnet therapy.

muscle twitches, tremulousness, and anxiet

foscarnet therapy

patient

experienced


Input: A case of timolol-associated heart failure in a 73-year old white man is reported.

a 73-year old white man

timolol

heart failure

associated


Input: In December, he was prescribed 160 mg/day tebipenem pivoxil by an otolaryngologist for inflammation of the tympanic membrane.

160 mg/day tebipenem pivoxil

he

for


Input: A 65-year-old female patient presented with jaundice followed 2 days later by severe dyspnea and tachypnea which worsened when patient was lying flat, 1 week after the fourth dose of adalimumab.

1 week after the fourth dose of adalimumab

jaundice followed 2 days later by severe dyspnea and tachypnea which worsened when patient was lying flat

A 65-year-old female patient

presented


Input: Renal failure is a rare complication associated with the use of rifampicin for the treatment of tuberculosis, usually occurring well into the course of therapy.

Renal failure

rifampicin

associated


Input: An autopsy case of multiple psychotropic drug poisoning.

poisoning

multiple psychotropic drug

An autopsy case

poisoning


Input: Severe heparin associated thrombocytopenia is a rare complication of heparin therapy.

heparin

thrombocytopenia

Severe

associated


Input: Six patients at steady state in treatment with indinavir participated in the study.

Six patients

indinavir

treatment


Input: RESULTS: A 52-year-old woman with Parkinson disease who had taken amantadine for 6 years had bilateral corneal edema for 2 months at baseline.

A 52-year-old woman with Parkinson disease

bilateral corneal edema for 2 months at baseline

taken amantadine for 6 years

had


Input: We report a case of a patient with pulmonary hypertension and undifferentiated connective tissue disease who, after 2 months of treatment with epoprostenol, presented with rapidly progressive erythema, scaling, nausea and vomiting, and fever.

2 months of treatment with epoprostenol

rapidly progressive erythema, scaling, nausea and vomiting, and fever

a patient with pulmonary hypertension and undifferentiated connective tissue disease

presented


Input: Neuroleptic malignant syndrome in an adolescent receiving olanzapine-lithium combination therapy.

Neuroleptic malignant syndrome

olanzapine-lithium combination therapy

adolescent

receiving


Input: A lethal complication of peripheral vein vasopressin infusion.

complication

peripheral vein vasopressin infusion

lethal

complication


Input: Cutaneous eruptions occur in 3% of individuals administered carbamazepine.

Cutaneous eruptions

carbamazepine

3% of individuals

occur


Input: A 27 year old female with a complex history of congenital heart disease, cardiac surgery, heart failure, and arrhythmias was admitted for a Pseudomonas aeruginosa sternal wound infection and treated with intravenous antibiotics.

A 27 year old female with a complex history of congenital heart disease, cardiac surgery, heart failure, and arrhythmias

intravenous antibiotics

treated


Input: Hyperkalaemia with renal tubular dysfunction by oral therapy of sulfamethoxazole-trimethoprim (co-trimoxazole) is described in 2 elderly Japanese patients with lymphoid malignancy, who developed Pneumocystis carinii pneumonia and improved.

oral therapy of sulfamethoxazole-trimethoprim (co-trimoxazole)

2 elderly Japanese patients with lymphoid malignancy

Hyperkalaemia with renal tubular dysfunction

described


Input: This is the first report on the histopathological findings of thyroid tissue from a patient with amiodarone-induced hypothyroidism.

hypothyroidism

amiodarone

induced


Input: Acute pulmonary reactions to nitrofurantoin are an uncommon side effect of therapy and can cause minor or life-threatening pulmonary dysfunction.

Acute pulmonary reactions

can cause minor or life-threatening pulmonary dysfunction

nitrofurantoin

can

minor or life-threatening

are


Input: High-dose cytosine arabinoside may benefit patients with refractory acute leukemia.

High-dose cytosine arabinoside

patients with refractory acute leukemia

may

benefit


Input: Life-threatening hyponatremia caused by vinblastine.

hyponatremia

vinblastine

caused


Input: We report a myeloma patient who developed severe paralytic ileus during bortezomib therapy, which presented in the context of progressive constipation without other known causes and which regressed promptly with medical management after drug cessation, suggesting a direct causal relationship.

a myeloma patient

paralytic ileus

presented in the context of progressive constipation without other known causes and which regressed promptly with medical management after drug cessation

bortezomib therapy

severe

developed


Input: Here, we report on the drug safety of coumarin with special respect to liver reaction.

coumarin

liver reaction

report

respect


Input: However, EO-induced noncardiogenic pulmonary edema has not been reported in human.

EO

noncardiogenic pulmonary edema

human

not

induced


Input: Since the thrombocyte count started to increase immediately after initiation and dropped immediately after discontinuation of ciprofloxacin and tazobactam/piperacillin and all other drugs were discontinued already before or were started after the nadir of the thrombocyte count, these two antibiotics were regarded causative.

discontinuation of ciprofloxacin and tazobactam/piperacillin

the thrombocyte count started to increase immediately after initiation and dropped immediately

Since


Input: However, in 1993, a clinical study involving 400 patients on the Thai-Burmese border revealed cardiac effects of antimalarial treatment with halofantrine, including one sudden death after the treatment.

halofantrine

400 patients on the Thai-Burmese border

cardiac effects

sudden death

effects


Input: Tetracycline-induced benign intracranial hypertension.

Tetracycline

benign intracranial hypertension

induced


Input: Only one case of a generalized maculopapular rash with enoxaparin has been reported in Europe.

one case

generalized maculopapular rash

enoxaparin

with


Input: After 3- to 13-month period of therapy without indapamide, glucose levels of all patients decreased and diabetes disappeared.

3- to 13-month period of therapy without indapamide

glucose levels of all patients decreased and diabetes disappeared

After


Input: The favourable outcome in these two patients contrasts with the fatal outcome of the two other reported cases of nitrofurantoin induced BOOP.

nitrofurantoin

BOOP

two patients

induced


Input: Skin necrosis after extravasation of low-dose vasopressin administered for septic shock.

vasopressin

Skin necrosis

extravasation


Input: The patient was previously on phenytoin and was initiated on ticagrelor for antiplatelet therapy following stent placement.

The patient

previously on phenytoin

initiated on ticagrelor

following stent placement

for


Input: Clonidine-induced bradycardia in patients with spinal cord injury.

Clonidine

bradycardia

patients with spinal cord injury

induced


Input: MI related to the use of activated and non-activated PCCs predominantly affects young patients who often have no preceding history of, or risk factors for, MI and tends to be associated with large cumulative doses of concentrate.

MI

activated and non-activated PCCs

large cumulative doses of concentrate

young patients who often have no preceding history of, or risk factors for, MI

related


Input: To our knowledge, we describe the first reported case of isolated paresthesia and peripheral neuropathy, without systemic involvement, secondary to sulindac administration.

isolated paresthesia and peripheral neuropathy

sulindac administration

To our knowledge

secondary


Input: To report a probable case of ticlopidine-induced phenytoin toxicity.

phenytoin

ticlopidine

a probable case

phenytoin toxicity

probable

induced


Input: Two patients are described in whom subtle cognitive impairments are associated with therapeutic doses of amoxapine.

therapeutic doses of amoxapine

subtle cognitive impairments

Two patients

subtle

associated


Input: Itraconazole is particularly attractive in fungal prophylaxis for cancer patients due to its broad spectrum, including Candida and Aspergillus.

Itraconazole

cancer patients

attractive

prophylaxis


Input: The authors think that although lamivudine is widely used and well tolerated, it can cause ADRs, which are reversible after drug withdrawal.

ADRs

lamivudine

cause


Input: Psoriasis induced by interferon-alpha.

Psoriasis

interferon-alpha

induced


Input: We report the first case of IHA associated with cefuroxime administration.

IHA

cefuroxime

the first case

associated


Input: We report a 16-year-old male who developed nephrotic syndrome related to membranous glomerulopathy with clinical and serological evidence of systemic lupus erythematosus after treatment with griseofulvin.

a 16-year-old male

treatment with griseofulvin

nephrotic syndrome related to membranous glomerulopathy with clinical and serological evidence of systemic lupus erythematosus

after


Input: CONCLUSION: In some abstainers who take cyanamide for several years, thin septum-like liver fibrosis progresses along with the emergence of ground-glass hepatocytes.

some abstainers

take cyanamide for several years

thin septum-like liver fibrosis progresses along with the emergence of ground-glass hepatocytes

In


Input: Metabolic acidosis induced by acetazolamide.

acetazolamide

Metabolic acidosis

induced


Input: In this paper we report a case of nimodipine overdosage resulting in prolonged hypotension and hypoxemia, which was successfully treated with calcium gluconate.

nimodipine overdosage

prolonged hypotension and hypoxemia

resulting

calcium gluconate

treated


Input: Valproic acid also displaces warfarin from the protein binding sites resulting in significant INR changes but this type of drug interaction is less well known.

Valproic acid also displaces warfarin from the protein binding sites

significant INR changes

less well known

resulting


Input: Therapy with IFN-alpha may be associated with a number of neuropsychiatric symptoms, such as Parkinsonism, akathisia, seizure, and depressive disorders.

neuropsychiatric symptoms, such as Parkinsonism, akathisia, seizure, and depressive disorders

Therapy with IFN-alpha

associated with


Input: DISCUSSION: The main adverse effects of leflunomide consist of diarrhea, nausea, liver enzyme elevation, hypertension, alopecia, and allergic skin reactions.

leflunomide

diarrhea, nausea, liver enzyme elevation, hypertension, alopecia, and allergic skin reactions

effects


Input: In a single practice during the 21 years 1971-1991, the incidence of gestational diabetes in pregnancies in which norethisterone was prescribed was 32.4% (22 of 69) in comparison with 7.1% in pregnancies in which the women did not take norethisterone (137 of 1,684) (p < 0.001).

gestational diabetes

pregnancies

norethisterone

incidence


Input: The development of systemic lupus erythematosus (SLE) after 38 months of therapy with recombinant human interferon gamma (rIFN-gamma) was observed in a patient with rheumatoid arthritis.

after 38 months

recombinant human interferon gamma

systemic lupus erythematosus

a patient with rheumatoid arthritis.

development


Input: To the best of our knowledge no comparable case and no discussion of possible complications of aspirin prophylaxis in patients with brain tumours have been published.

patients with brain tumours

aspirin prophylaxis

no

complications


Input: CASE REPORT: We present a case of a 28-yr-old male who developed a severe case of nephrotic syndrome while being treated for relapsing/remitting Multiple Sclerosis (RRMS) with weekly injections of interferon beta 1a.

28-yr-old male

relapsing/remitting Multiple Sclerosis (RRMS)

nephrotic syndrome

weekly injections of interferon beta 1a

severe case

developed


Input: This is the third report of reversible hepatic decompensation associated with prolonged MTX therapy in patients with rheumatoid arthritis.

reversible hepatic decompensation

MTX

patients with rheumatoid arthritis

associated


Input: CONCLUSIONS: Acute severe hepatitis though rare is occasionally observed with EGFR inhibitors gefitinib or erlotinib.

EGFR inhibitors gefitinib or erlotinib

Acute severe hepatitis

severe

observed


Input: Propafenone is an established class IC antiarrhythmic drug commonly used in the treatment of atrial fibrillation.

Propafenone

treatment


Input: Reversible nonthrombocytopenic palpable purpura associated with metoclopramide.

metoclopramide

Reversible nonthrombocytopenic palpable purpura

associated


Input: Physicians who use sulfasalazine to treat patients with inflammatory bowel disease should be aware of the signs of sulfasalazine-induced lupus syndrome.

sulfasalazine

sulfasalazine

lupus syndrome

induced


Input: Transient hemiparesis caused by phenytoin toxicity.

Transient hemiparesis

phenytoin toxicity

caused


Input: Sensorineural hearing loss due to quinine therapy for malaria has frequently been mentioned in the literature but has not been a subject of research during the last decades.

quinine

Sensorineural hearing loss

frequently been mentioned

due


Input: We report a 78-year-old man who had acute unilateral total visual loss after retrogasserian phenol injection for the treatment of trigeminal neuralgia.

retrogasserian phenol injection

a 78-year-old man

acute unilateral total visual loss

after


Input: Four months after receiving an orthotopic liver transplant, a 51-year-old man was admitted for progressive liver failure and severe hepatocellular necrosis thought to be due to tacrolimus.

tacrolimus

progressive liver failure and severe hepatocellular necrosis

Four months after receiving an orthotopic liver transplant, a 51-year-old man

due to


Input: Patients receiving neutral protamine Hagedorn (NPH) insulin are at increased risk for the development of protamine hypersensitivity.

protamine hypersensitivity

Patients

neutral protamine Hagedorn (NPH) insulin

increased risk

development


Input: The second patient, who developed cholestasis after receiving trimethoprim-sulfamethoxazole, had marked duct paucity in the liver biopsy.

The second patient

cholestasis

duct paucity

trimethoprim-sulfamethoxazole

developed


Input: We describe a patient who became hypothyroid while taking ferrous sulfate.

hypothyroid

ferrous sulfate

a patient

became


Input: Allergy to cloxacillin with normal tolerance to amoxicillin and cefuroxime.

Allergy

cloxacillin

to


Input: Triazolam-induced nocturnal bingeing with amnesia.

Triazolam

nocturnal bingeing with amnesia

induced


Input: Ticlopidine-induced aplastic anemia (TIAA) is considered very uncommon.

Ticlopidine

aplastic anemia (TIAA)

uncommon

induced


Input: One case report describes an interaction between simvastatin and the anticoagulant acenocoumarol, which resulted in an elevated INR.

simvastatin and the anticoagulant acenocoumarol

elevated INR

One case

resulted


Input: A 35-year-old woman presented with neurotoxicity correlated to an i.v. regimen of 5-fluorouracil as episodes of acute confusional state and abnormalities of symmetrically restricted diffusion in the periventricular white matter and corpus callosum.

an i.v. regimen of 5-fluorouracil

neurotoxicity

acute confusional state and abnormalities of symmetrically restricted diffusion in the periventricular white matter and corpus callosum

A 35-year-old woman

correlated


Input: Ampicillin may aggravate clinical and experimental myasthenia gravis.

Ampicillin

myasthenia gravis

may

aggravate


Input: In the present paper, we discuss the first Japanese vivax malaria patient whose QT interval was prolonged after treatment with halofantrine.

Japanese vivax malaria patient

halofantrine

QT interval was prolonged

after


Input: The Center for Disease Control has received numerous reports of an eosinophilia-myalgia syndrome related to products containing L-tryptophan.

products containing L-tryptophan

eosinophilia-myalgia syndrome

related


Input: Disopyramide (Norpace)-induced hypoglycemia.

Disopyramide (Norpace)

hypoglycemia

induced


Input: A case report of the hypersensitivity syndrome occurring in a patient being treated with dapsone for a brown recluse spider bite is presented.

dapsone

hypersensitivity syndrome

a patient

treated


Input: AIMS: To present a case of piloerection after replacing fluvoxamine maleate with milnacipran hydrochloride, and to analyse this effect based on receptor occupancy theory.

piloerection

fluvoxamine maleate

after


Input: Serotonin syndrome after concomitant linezolid and meperidine therapy has not been described.

Serotonin syndrome

linezolid and meperidine

not

after


Input: She presented to clinic with nausea and anorexia within a few days of addition of ciprofloxacin to her current regimen of medications, which included digoxin.

addition of ciprofloxacin to her current regimen of medications, which included digoxin

nausea and anorexia

She

presented


Input: Disulfiram-induced fulminant hepatic failure in an active duty soldier.

an active duty soldier

Disulfiram

fulminant hepatic failure

induced


Input: BACKGROUND: We report six cases of psychosis in patients with akinetic-rigid syndromes who were treated with risperidone.

six cases

patients with akinetic-rigid syndromes

risperidone

treated


Input: Colonic necrosis is known as a rare complication following the administration of Kayexalate (sodium polystryrene sulfonate) in sorbitol.

Colonic necrosis

Kayexalate (sodium polystryrene sulfonate) in sorbitol

following


Input: Anaphylaxis to cisplatin is an infrequent life-threatening complication which may occur even in patients who have received prior treatment with cisplatin.

Anaphylaxis

cisplatin

patients

life-threatening

occur


Input: Piloerection induced by replacing fluvoxamine with milnacipran.

Piloerection

replacing fluvoxamine with milnacipran

induced


Input: Ethambutol is an antimicrobial agent used frequently to treat tuberculosis.

Ethambutol

frequently

treat


Input: The purpose of this review is to increase awareness among physicians and other health care professionals that DIC may be a rare but potentially severe complication of anti-D IGIV treatment.

DIC

anti-D IGIV

complication


Input: Four Chinese female patients who suffered from manic-depressive disorder and underlying autoimmune thyroiditis developed transient episodes of thyrotoxicosis during maintenance lithium therapy.

transient episodes of thyrotoxicosis

Four Chinese female patients who suffered from manic-depressive disorder and underlying autoimmune thyroiditis

maintenance lithium therapy

during


Input: Neurointensive care management of raised intracranial pressure caused by severe valproic acid intoxication.

raised intracranial pressure

valproic acid

caused


Input: Primary ovarian large B-cell lymphoma in patient with juvenile rheumatoid arthritis treated with low dose Methotrexate.

patient with juvenile rheumatoid arthritis

low dose Methotrexate

Primary ovarian large B-cell lymphoma

in


Input: Asterixis induced by carbamazepine therapy.

carbamazepine

Asterixis

induced


Input: Ifosfamide is a known nephrotoxic drug with demonstrated tubulopathies.

tubulopathies

Ifosfamide

with


Input: A case of noncardiogenic pulmonary edema by ethanolamine oleate.

ethanolamine oleate

noncardiogenic pulmonary edema

A case

by


Input: A boy with chronic neutropenia and recurrent inflammatory skin lesions developed multiple erythematous nodules following administration of G-CSF.

A boy with chronic neutropenia and recurrent inflammatory skin lesions

multiple erythematous nodules

G-CSF

developed


Input: Fulminant hepatitis and lymphocyte sensitization due to propylthiouracil.

propylthiouracil

Fulminant hepatitis

lymphocyte sensitization

Fulminant

due


Input: We report on three patients with acute schizophrenia, who developed severe akathisia during treatment with olanzapine (20-25 mg/d).

three patients with acute schizophrenia

akathisia

olanzapine (20-25 mg/d)

severe

with


Input: AIMS/HYPOTHESIS: There is evidence that insulin and glucose cause renal and ocular vasodilation.

insulin and glucose

renal and ocular vasodilation

cause


Input: A cause-effect relationship to capecitabine was suggested due to resolution of headache with capecitabine withdrawal and reappearance with capecitabine rechallenge.

capecitabine

headache

relationship to


Input: This is a report of a case of anuric ARF after high-dose mannitol infusion for treatment of narrow-angle glaucoma that readily responded to acute hemodialysis.

a case

anuric ARF

high-dose mannitol infusion

readily

after


Input: She was treated with sorafenib at 400 mg daily.

She

sorafenib at 400 mg daily

treated


Input: The clinical course suggested that recombinant alpha-2b peginterferon plus ribavirin provoked type 1 diabetes mellitus, therefore, in patients who are candidates for interferon therapy the presence of pancreatic autoantibodies and the fasting plasma glucose level should be investigated before and during treatment.

recombinant alpha-2b peginterferon plus ribavirin

type 1 diabetes mellitus

provoked


Input: Rhabdomyolysis following clarithromycin monotherapy.

Rhabdomyolysis

clarithromycin monotherapy

following


Input: In addition to its known effect on gallbladder stasis, octreotide alters bile acid composition and may thus hasten intrahepatic sludge and stone formation.

gallbladder stasis

alters bile acid composition and may thus hasten intrahepatic sludge and stone formation

octreotide

effect on


Input: A 17-year-old boy with acute lymphoblastic leukemia developed acute renal failure within 48 h of an intravenous high-dose methotrexate (5 g/m2) infusion.

17-year-old boy with acute lymphoblastic leukemia

acute renal failure

intravenous high-dose methotrexate (5 g/m2) infusion

developed


Input: Splenic hemorrhage: a complication of tissue plasminogen activator treatment.

Splenic hemorrhage

tissue plasminogen activator treatment

complication of


Input: CONCLUSIONS: Cefazolin was a probable cause of this patient's leukopenia.

Cefazolin

patient

leukopenia

probable

cause


Input: Paradoxical cerebral cortical hyperexcitability following flupirtine overdose.

Paradoxical cerebral cortical hyperexcitability

flupirtine overdose

following


Input: Autopsy evidence of herpesvirus infection was found in visceral organs of four leukemic patients who had received large doses of cytarabine (cytosine arabinoside; Ara-C) shortly before their death.

herpesvirus infection

four leukemic patients

large doses of cytarabine

found


Input: Heparin-induced hyperkalemia.

Heparin

hyperkalemia

induced


Input: Although myelosuppression is mild, immunosuppression and superinfection are potential hazards of treatment with DCF.

DCF

myelosuppression

immunosuppression and superinfection

mild

potential

hazards


Input: The photosensitivity is still present 3 years after the withdrawal of quinine.

withdrawal of quinine

photosensitivity is still present 3 years

after


Input: Interference with the cortisol axis by the microtubule antagonist, CPH82.

Interference with the cortisol axis

by


Input: Physicians should be aware of the possible association between the use of alteplase and the development of subfascial hemorrhage.

subfascial hemorrhage

alteplase

possible

development


Input: The clinical findings and laboratory studies suggested an autoimmune cell-mediated hypersensitivity reaction triggered by phenobarbital.

phenobarbital

an autoimmune cell-mediated hypersensitivity reaction

triggered


Input: Anaphylactic reaction to oral prednisone: a case report and review of the literature.

Anaphylactic reaction

oral prednisone

a case

to


Input: Prolonged prostate-specific antigen response in flutamide withdrawal syndrome despite disease progression.

flutamide

Prolonged prostate-specific antigen response

in


Input: None of them had a history of cardiac disease, and with the possible exception of one case of cardiac arrest, where the patient received doxorubicin, no predisposing factors could be found.

cardiac arrest

doxorubicin

the patient

received


Input: We report a case of IDDM which occurred during interferon therapy for chronic hepatitis.

IDDM

interferon therapy

a case

occurred


Input: Though physicians treating large populations of patients with HIV are well aware of this complication, only one other report of nevirapine-associated SJS has been documented in the dermatology literature.

nevirapine

SJS

patients with HIV

associated


Input: We report a case of baclofen withdrawal syndrome resulting from oral baclofen underdosing.

baclofen withdrawal syndrome

oral baclofen underdosing

resulting


Input: A 35-year-old nephrotic man developed acute renal failure with serum creatinine to 1543 micromol/l after a month of therapy with enalapril.

a month of therapy with enalapril

acute renal failure with serum creatinine to 1543 micromol/l

A 35-year-old nephrotic man

acute

after


Input: Comparable adverse effects, such as disorientation and temporary amnesia, have been reported in patients in the analogous agent, propranolol.

propranolol

disorientation and temporary amnesia

patients

been reported


Input: This is an image and brief case report of a 13-year-old boy who presented with severe rash and systemic symptoms after starting oxcarbazepine.

oxcarbazepine

severe rash and systemic symptoms

a 13-year-old boy

severe

after


Input: Renal damage associated with long term use of lithium carbonate.

Renal damage

lithium carbonate

associated


Input: Triamcinolone acetonide induced secondary adrenal insufficiency related to impaired CYP3A4 metabolism by coadministration of nefazodone.

Triamcinolone acetonide

coadministration of nefazodone

secondary adrenal insufficiency

induced


Input: Hepatocellular damage following therapeutic intravenous iron sucrose infusion in a child.

a child

Hepatocellular damage

intravenous iron sucrose infusion

following


Input: We report a 43-year-old woman who developed sore throat, swelling of the lips and oral cavity and dysphagia, 2 weeks after the use of budesonide spray (Budefat) for treatment of bronchial asthma.

a 43-year-old woman

sore throat, swelling of the lips and oral cavity and dysphagia

2 weeks after the use of budesonide spray (Budefat)

developed


Input: Among the risk factors studied, two appear to increase the risk of ARE: the prescription of thiabendazole to treat strongyloidiasis during the melarsoprol cure and the bad general clinical conditions of patients.

prescription of thiabendazole

during the melarsoprol cure

increase the risk of ARE

appear to

appear to


Input: Review of this and previously reported cases indicates the need for early diagnosis of amiodarone pneumonitis, immediate withdrawal of amiodarone, and prompt but continued steroid therapy to ensure full recovery.

amiodarone

pneumonitis

of

immediate withdrawal of amiodarone, and prompt but continued steroid therapy

recovery


Input: A second possibility is an interaction between clarithromycin and isradipine, potentially increasing the hepatic toxicity of isradipine.

hepatic toxicity

interaction between clarithromycin and isradipine

potentially

increasing


Input: We report two cases of cerebrospinal fluid eosinophilia (CSFE) secondary to the intraventricular administration of vancomycin.

intraventricular administration of vancomycin

cerebrospinal fluid eosinophilia (CSFE)

two cases

secondary


Input: We describe two patients who experienced serious quetiapine adverse effects potentially mediated through an interaction with ritonavir-boosted atazanavir.

two patients

serious quetiapine adverse effects

ritonavir-boosted atazanavir

potentially

experienced


Input: The patient was diagnosed with carbamazepine toxicity related to the introduction of ritonavir.

ritonavir

patient

carbamazepine toxicity

related


Input: Caution should be exercised, especially in patients who are given voriconazole or fluconazole during long-lasting fentanyl treatment, because insidiously elevated fentanyl concentration may lead to respiratory depression.

patients

fentanyl

respiratory depression

lead


Input: This review presents the first case series of DIC associated with acute hemoglobinemia or hemoglobinuria following anti-D IGIV administration for ITP.

DIC associated with acute hemoglobinemia or hemoglobinuria

anti-D IGIV administration

following


Input: Risperidone is a frequently used member of a new class of atypical antipsychotics-the serotonin-dopamine antagonists (SDAs)-due to its comparatively high efficacy and low D2/5HT2 binding ratio, which results in a low incidence of extrapyramidal side effects including tardive dyskinesia (TD).

Risperidone

tardive dyskinesia

results


Input: A 5-month-old infant became lethargic and poorly responsive after receiving 1 drop of brimonidine in each eye.

A 5-month-old infant

lethargic and poorly responsive

receiving 1 drop of brimonidine in each eye

became


Input: The authors report 2 cases of renal damage associated with lithium carbonate treatment.

renal damage

lithium carbonate treatment

2 cases

associated


Input: It was hypothesized that valproic acid may interfere with glucuronidation of lamotrigine, leading to increased serum lamotrigine levels, or perhaps alter the drug's metabolism, resulting in accumulation of a toxic intermediate metabolite.

valproic acid may interfere with glucuronidation of lamotrigine

increased serum lamotrigine levels, or perhaps alter the drug's metabolism, resulting in accumulation of a toxic intermediate metabolite

hypothesized

leading


Input: Portal vein thrombosis in a patient with severe haemophilia A and F V G1691A mutation during continuous infusion of F VIII after intramural jejunal bleeding--successful thrombolysis under heparin therapy.

continuous infusion of F VIII

a patient with severe haemophilia A and F V G1691A mutation

Portal vein thrombosis

during

heparin

successful thrombolysis

therapy


Input: A healthy, 30-year-old man, exposed to sulindac on two separate occasions, had an incapacitating isolated idential sensory neuropathy.

incapacitating isolated idential sensory neuropathy

A healthy, 30-year-old man

sulindac

exposed


Input: Clofibrate-induced myopathy in patients with diabetes insipidus.

Clofibrate

myopathy

patients with diabetes insipidus

induced


Input: This is the first histologically confirmed case of NASH that was aggravated by raloxifene.

NASH

raloxifene

the first histologically confirmed case

aggravated


Input: To date, eight cases of TEN and one of SJS related to lamotrigine administration have been reported in the literature.

lamotrigine

TEN

SJS

related


Input: ARA-C is frequently associated with dermatologic toxicity, but this is only the second case of toxic epidermal necrolysis described in connection with this drug.

ARA-C

dermatologic toxicity

associated


Input: Hyperglycemia and diabetic coma: possible relationship to diuretic-propranolol therapy.

Hyperglycemia and diabetic coma

propranolol

to


Input: Potential mechanisms involved in the occurrence of ischemic colitis in patients receiving tegaserod are also discussed.

ischemic colitis

tegaserod

patients

occurrence


Input: Anaphylaxis to intravenous cyclosporine and tolerance to oral cyclosporine: case report and review.

Anaphylaxis

intravenous cyclosporine

case

to


Input: CASE REPORT: A woman of 80 years, on long-term warfarin therapy presented with an acute dissecting thoracic aortic aneurysm; on investigation the only precipitating factor found was an international normalised ratio of 4.8.

A woman of 80 years

on long-term warfarin

acute dissecting thoracic aortic aneurysm

presented


Input: A patient with an allergy to a macrolide antibiotic was given tacrolimus and developed a sudden cutaneous reaction.

sudden cutaneous reaction

A patient with an allergy to a macrolide antibiotic

given tacrolimus

developed


Input: This case suggests the importance of careful observation for extramedullary relapse in patients who are treated with ATRA.

extramedullary relapse

patients

ATRA

suggests

treated


Input: Olanzapine-associated neuroleptic malignant syndrome.

Olanzapine

neuroleptic malignant syndrome

associated


Input: Acute dystonia induced by lamivudine.

Acute dystonia

lamivudine

induced


Input: We report in detail an unusual adverse reaction to infliximab therapy, a drug-induced lupus-like clinical syndrome.

infliximab

lupus-like clinical syndrome

induced


Input: RESULTS: Quetiapine was associated with leucopenia in two patients and clinically apparent agranulocytosis in one patient.

Quetiapine

leucopenia

two patients

associated

Quetiapine

clinically apparent agranulocytosis

one patient

associated


Input: Oral intake and acarbose were withheld and the ileus spontaneously resolved after 2 days.

Oral intake and acarbose

the ileus spontaneously resolved

after


Input: No explanation for this delay was found, other than the possibility that magnesium sulfate treatment impeded lactogenesis.

magnesium sulfate

lactogenesis

impeded


Input: Although its side effects are few, tamoxifen increases the incidence of proliferative lesions of the endometrium, which theoretically should be preventable with progestational agents.

tamoxifen

incidence of proliferative lesions of the endometrium

increases


Input: Three senile patients developed fatal acute encephalopathy while receiving calcium hopantenate.

Three senile patients

encephalopathy

calcium hopantenate

fatal

developed


Input: Renal injury due to anastrozole has not been published in the English literature.

Renal injury

anastrozole

not

due


Input: Facial, tongue, and arm movements were first reported approximately five weeks after the initiation of aripiprazole.

initiation of aripiprazole

Facial, tongue, and arm movements

after


Input: Restless legs syndrome due to interferon-alpha.

Restless legs syndrome

interferon-alpha

due


Input: HUS has been reported after several anticancer chemotherapies and most often after mitomycin C-based chemotherapy regimens.

HUS

several anticancer chemotherapies and most often after mitomycin C-based chemotherapy regimens

reported


Input: Although the association between SJS/TEN and the sulfonamide class of antibiotics is well established, the increasing prevalence of CA-MRSA has left practitioners with limited regimens to effectively treat skin and soft tissue infections (SSTIs) in the outpatient setting.

sulfonamide class of antibiotics

SJS/TEN

CA-MRSA

association


Input: Acute non-lymphocytic leukemia occurred in eight women following long-term treatment with Treosulfan (= dihydroxybusulfan) for ovarian carcinoma.

Acute non-lymphocytic leukemia

eight women

Treosulfan (= dihydroxybusulfan)

occurred


Input: Elderly patients for whom nitrate has been prescribed should be warned of the occurrence of hypotension, leading to unconsciousness.

Elderly patients

nitrate

hypotension

unconsciousness

occurrence


Input: A patient receiving vancomycin for a serious staphylococcal infection had a lupus-like syndrome characterized by a malar rash, pain and erythema of the cartilage of both ears, and tender erythematous and hemorrhagic lesions of the finger tips.

vancomycin

a lupus-like syndrome characterized by a malar rash, pain and erythema of the cartilage of both ears, and tender erythematous and hemorrhagic lesions of the finger tips

serious

had


Input: Seven patients with hematologic malignancies who were treated with miconazole for either suspected or proven fungal infections developed eight episodes of major adverse cardiorespiratory and anaphylactic reactions.

Seven patients with hematologic malignancies

miconazole

eight episodes of major adverse cardiorespiratory and anaphylactic reactions

developed


Input: We report the first case, to our knowledge, of rituximab-related autoimmune hemolytic anemia.

rituximab

autoimmune hemolytic anemia

first

related


Input: Anaphylactoid reactions with intraperitoneal cisplatin.

intraperitoneal cisplatin

Anaphylactoid reactions

with


Input: Tremor: a newly described adverse event with long-term itraconazole therapy.

long-term itraconazole therapy

Tremor

with


Input: Treatment-related myelodysplastic syndrome after temozolomide for recurrent high-grade glioma.

myelodysplastic syndrome

temozolomide

after


Input: It occasionally accompanies the heparin-associated thrombocytopenia and thrombosis syndrome.

heparin

thrombocytopenia and thrombosis syndrome

associated


Input: We report an unusual case of massive fluoxetine ingestion resulting in neurological and cardiovascular toxicity resulting in death.

massive fluoxetine ingestion

neurological and cardiovascular toxicity resulting in death

an unusual case

resulting in


Input: Although dyspnea associated with verapamil administration has been reported, this is the first report of an elderly asymptomatic asthmatic patient with hypertension who developed an acute asthma attack following sustained-release verapamil administration.

an elderly asymptomatic asthmatic patient with hypertension

an acute asthma attack

sustained-release verapamil administration

developed


Input: The bleeding resolved on discontinuation of APV.

discontinuation of APV

resolved


Input: We describe a case of infection with Mycobacterium abscessus in a 67-year-old woman receiving infliximab as a component of her therapy for RA.

a 67-year-old woman

RA

infection with Mycobacterium abscessus

infliximab as a component of her therapy

receiving


Input: Renal toxicities have been reported in less than one percent of the patients receiving ciprofloxacin therapy.

Renal toxicities

ciprofloxacin therapy.

less than one percent of the patients

reported


Input: Taxane-induced glaucoma.

Taxane

glaucoma

induced


Input: Ciprofloxacin-induced toxic epidermal necrolysis in a patient with systemic lupus erythematosus.

Ciprofloxacin

toxic epidermal necrolysis

a patient with systemic lupus erythematosus.

nduced


Input: Hypotension due to interaction between lisinopril and tizanidine.

interaction between lisinopril and tizanidine

Hypotension

due to


Input: Development of an extensive skin rash following a single dose of MTX may be an early warning sign for life-threatening bone marrow aplasia.

extensive skin rash

MTX

following


Input: Anaphylactoid reaction to 50% solution of dextrose.

Anaphylactoid reaction

50% solution of dextrose

to


Input: Hypokalemia after normal doses of neubulized albuterol (salbutamol).

Hypokalemia

normal doses of neubulized albuterol (salbutamol)

after


Input: Although praziquantel administration may have been effective in killing the parasite in both patients, we are concerned about the production of marked inflammation as a result of treatment.

marked inflammation

praziquantel

parasite in both patients

may

production


Input: We describe a patient who developed granulocytopenia and fever after taking dipyrone and discuss the available literature.

a patient

granulocytopenia and fever

taking dipyrone

developed


Input: Spectral-domain optical coherence tomography and adaptive optics may detect hydroxychloroquine retinal toxicity before symptomatic vision loss.

hydroxychloroquine

symptomatic vision loss

before


Input: A 64-year-old man presented with proteinuria during postoperative interferon (IFN)-beta therapy against malignant melanoma.

proteinuria

postoperative interferon (IFN)-beta therapy

A 64-year-old man

during


Input: Ethambutol toxicity manifesting as acute onset psychosis.

Ethambutol

acute onset psychosis

toxicity


Input: Cholesterol crystal embolization-associated renal failure after therapy with recombinant tissue-type plasminogen activator.

therapy with recombinant tissue-type plasminogen activator

Cholesterol crystal embolization-associated renal failure

after


Input: METHODS: A 76-year-old woman with primary open-angle glaucoma and no history of ocular surgery developed a choroidal detachment 12 hours after initiation of therapy with dorzolamide eye drops.

A 76-year-old woman with primary open-angle glaucoma and no history of ocular surgery

choroidal detachment

12 hours after initiation of therapy with dorzolamide eye drops

developed


Input: Life-threatening hyperkalemia induced by arginine.

hyperkalemia

arginine

Life-threatening

induced