Input: OBJECTIVE: To test the hypothesis that tumor necrosis factor (TNF)-alpha may mediate the loss and the dedifferentiation of subcutaneous fat tissue in the insulin-induced lipoatrophies of a diabetic patient who presented extensive lesions.

insulin

lipoatrophies

induced


Input: An evaluation of ovarian structure and function should be considered in women of reproductive age being treated with valproate for epilepsy, especially if they develop menstrual cycle disturbances during treatment.

women of reproductive age

valproate for epilepsy

menstrual cycle disturbances

develop


Input: Phenobarbital hepatotoxicity in an 8-month-old infant.

an 8-month-old infant

Phenobarbital

hepatotoxicity

in


Input: The authors report a case of Balint syndrome with irreversible posterior leukoencephalopathy on MRI following intrathecal methotrexate and cytarabine.

intrathecal methotrexate and cytarabine

Balint syndrome with irreversible posterior leukoencephalopathy on MRI

following


Input: According to the Naranjo probability scale, flecainide was the probable cause of the patient's delirium; the Horn Drug Interaction Probability Scale indicates a possible pharmacokinetic drug interaction between flecainide and paroxetine.

flecainide

delirium

the patient

probable

cause


Input: Contact dermatitis due to budesonide: report of five cases and review of the Japanese literature.

Contact dermatitis

budesonide

due


Input: Prolongation of the QT interval observed in a Japanese patient with vivax malaria following treatment with halofantrine.

a Japanese patient with vivax malaria

Prolongation of the QT interval

halofantrine

following


Input: We report three cases of severe hepatotoxicity related to benzarone, a benzofuran derivative.

three cases

severe hepatotoxicity

benzarone

related


Input: Four patients who manifested symptoms of the antiepileptic drug (AED) hypersensitivity syndrome during therapy with carbamazepine are reported.

Four patients

hypersensitivity syndrome

antiepileptic drug (AED)

during therapy with carbamazepine

symptoms of


Input: Minocycline as a cause of drug-induced autoimmune hepatitis.

autoimmune hepatitis

Minocycline

induced


Input: Secondary acute myeloid leukemia after etoposide therapy for haemophagocytic lymphohistiocytosis.

Secondary acute myeloid leukemia

etoposide therapy

after


Input: Allergic contact angioedema to benzoyl peroxide.

Allergic contact angioedema

benzoyl peroxide

to


Input: A 60-year-old white man with chronic bronchitis was noted to develop acute respiratory failure and metabolic acidosis four days after being started on methazolamide (Neptazane) for an ophthalmologic problem.

A 60-year-old white man with chronic bronchitis

acute respiratory failure and metabolic acidosis

methazolamide (Neptazane)

develop


Input: L-DOPA-induced excessive daytime sleepiness in PD: a placebo-controlled case with MSLT assessment.

L-DOPA

daytime sleepiness

induced


Input: CONCLUSIONS: It is probable that foscarnet contributed to the electrolyte disorders and symptomatology in this patient.

foscarnet

electrolyte disorders and symptomatology

this patient

probable

contributed


Input: Acute drug induced hepatitis due to erlotinib.

Acute drug induced hepatitis

erlotinib

due


Input: We observed 3 diabetic patients with intolerable dizziness followed by nausea and vomiting immediately after an initial administration of the alpha-glucosidase inhibitor, voglibose.

3 diabetic patients

intolerable dizziness followed by nausea and vomiting

an initial administration of the alpha-glucosidase inhibitor, voglibose

after


Input: Although risk factors for MTX-induced pulmonary toxicity are poorly understood, the presence in 3 out of 5 of our patients of pre-existing lung disease, represented by diffuse interstitial changes on chest X-ray, and mild bronchial asthma in two RA patients and by pulmonary silicosis in the patient with PsA may account for a predisposition to the development of MTX pneumonitis.

MTX

pulmonary toxicity

the presence in 3 out of 5 of our patients of pre-existing lung disease, represented by diffuse interstitial changes on chest X-ray, and mild bronchial asthma in two RA patients and by pulmonary silicosis in the patient with PsA

induced


Input: Acute esmolol toxicity may be self-limiting because of its extremely short half-life.

esmolol

toxicity

may

be


Input: The association with prolonged unopposed estrogen-like stimulation with tamoxifen as a possible factor in the development of ovarian endometrioid carcinoma is discussed.

development of ovarian endometrioid carcinoma

prolonged unopposed estrogen-like stimulation with tamoxifen

possible factor

with


Input: The other woman had rheumatoid arthritis and developed acute tubular necrosis after treatment with gentamicin and cefoxitin.

acute tubular necrosis

The other woman had rheumatoid arthritis

gentamicin and cefoxitin

developed


Input: One patient who received clindamycin had liver biopsy findings of marked cholestasis, portal inflammation, bile duct injury and bile duct paucity (ductopenia).

clindamycin

One patient

marked cholestasis, portal inflammation, bile duct injury and bile duct paucity (ductopenia)

marked

had


Input: A MEDLINE search (1966-January 2009) revealed one in vivo pharmacokinetic study on the interaction between flecainide, a CYP2D6 substrate, and paroxetine, a CYP2D6 inhibitor, as well as 3 case reports of flecainide-induced delirium.

flecainide

delirium

3 case reports

induced


Input: As these cases revealed, close monitoring of blood chemistry is mandatory after starting spironolactone, and patients should be advised to stop spironolactone immediately if diarrhoea develops.

spironolactone

diarrhoea

patients

develops


Input: When these cells are exposed to nicotinic acid, an exaggerated immune response is produced that may lead to pain, redness, and swelling at the injection site.

nicotinic acid

exaggerated immune response

pain, redness, and swelling at the injection sit

may

produced


Input: A case of heatstroke is reported in a 32-year-old man diagnosed with schizophrenia and on clozapine monotherapy.

heatstroke

clozapine monotherapy

a 32-year-old man diagnosed with schizophrenia

reported


Input: Paraplegia following intrathecal cytosine arabinoside.

Paraplegia

intrathecal cytosine arabinoside

following


Input: Cimetidine-induced fever.

Cimetidine

fever

induced


Input: This case report illustrates the neurotoxicity unique to HDARAC.

HDARAC

This case

neurotoxicity unique

to


Input: Agranulocytosis associated with ticlopidine: a possible benefit with filgastim.

ticlopidine

Agranulocytosis

associated


Input: Since SS is a clinical diagnosis, heightened clinician awareness of the possibility of SS among patients receiving SSRI or mirtazapine in combination with opioids may lead to earlier detection and avoidance of potentially lethal consequences.

potentially lethal consequences

patients

SSRI or mirtazapine in combination with opioids

lead to


Input: The mechanism by which sunitinib induces gynaecomastia is thought to be associated with an unknown direct action on breast hormonal receptors.

sunitinib

gynaecomastia

induces


Input: Some patients develop hypersensitivity rash in response to HCQ.

Some patients

hypersensitivity rash

HCQ

develop


Input: To report a case of serotonin toxicity, presenting in the postoperative period, caused by an interaction between paroxetine (a selective serotonin reuptake inhibitor, SSRI) and fentanyl (a phenylpiperidine opioid).

serotonin toxicity

paroxetine

fentanyl

caused


Input: However, to our knowledge, in newborns there have been no reported cases to date of thrombocytosis induced by enoxaparin.

newborns

thrombocytosis

enoxaparin

no

induced


Input: The case presented here documents adverse cardiac effects in a 28-year-old man who intentionally ingested 24 mg of risperidone--4 times the recommended dose.

adverse cardiac effects

28-year-old man

24 mg of risperidone

ingested


Input: Anaphylaxis to cisplatin following nine previous uncomplicated cycles.

Anaphylaxis

cisplatin following nine previous uncomplicated cycles

to


Input: To the best of the authors' knowledge, this is the first reported case of Propecia-associated cataract.

Propecia

cataract

associated


Input: Serotonin syndrome caused by interaction between citalopram and fentanyl.

Serotonin syndrome

citalopram and fentanyl

caused


Input: We report on three observations of parkinsonian patients with levo-dopa-induced diphasic dyskinesias, who received subcutaneous apomorphine to reduce the duration of abnormal movements.

levo-dopa

diphasic dyskinesias

parkinsonian patients

induced

parkinsonian patients

subcutaneous apomorphine

reduce


Input: This report presents a case of acute lung injury developing within hours after administration of mefloquine for a low-level Plasmodium falciparum malaria, which was persistent despite halofantrine therapy.

acute lung injury

persistent despite halofantrine therapy

administration of mefloquine for a low-level Plasmodium falciparum malaria

halofantrine therapy

after


Input: Warfarin-associated bleeding generally is considered deleterious; however, in our patient it unmasked an early stage of colon cancer and thus may have saved the patient's life.

Warfarin

bleeding

generally

associated

associated


Input: The clinical use of itraconazole in patients receiving multiple doses of oxycodone for pain relief may increase the risk of opioid-associated adverse effects.

itraconazole

receiving multiple doses of oxycodone

opioid-associated adverse effects

patients

may

increase


Input: Three cases of gold-related neuropathy are reported.

gold

neuropathy

Three cases

related


Input: We report the case of a man, treated with mesalazine for Crohn's disease who developed drug-induced pericarditis.

drug-induced pericarditis

a man

mesalazine

developed


Input: We report the occurrence of spontaneous intracranial bleeding in an human immunodeficiency virus (HIV)-infected adolescent with hemophilia A who was receiving amprenavir (APV).

spontaneous intracranial bleeding

an human immunodeficiency virus (HIV)-infected adolescent with hemophilia A

amprenavir (APV)

occurrence


Input: Under the suspicion of amiodarone-induced acute pancreatitis, amiodarone was substituted by propafenone.

amiodarone

acute pancreatitis

induced


Input: Evidence is shown in this report that adenosine was associated with dangerous worsening of arrhythmia in patients with atrial flutter.

dangerous worsening of arrhythmia

patients with atrial flutter

adenosine

associated


Input: Salicylate hepato toxicity in rheumatic fever.

Salicylate

hepato toxicity

toxicity


Input: A case of serotonin syndrome that developed during concurrent linezolid and fluoxetine is presented.

concurrent linezolid and fluoxetine

serotonin syndrome

developed


Input: Herein we report four patients who underwent liver transplantation and developed neutropenia while receiving MMF.

MMF

neutropenia

four patients who underwent liver transplantation

developed


Input: A study of in vitro reactivity to L-T4, as assessed by peripheral blood lymphocyte transformation, was carried out in a patient with Hashimoto's disease who developed leukopenia during treatment with L-T4.

leukopenia

a patient with Hashimoto's disease

developed


Input: Methemoglobinemia is another common finding among patients receiving dapsone therapy, but rarely does it result in prominent symptoms other than transient pallor.

dapsone therapy

patients

Methemoglobinemia

transient pallor

receiving


Input: During the first treatment, dysarthria and ataxia were seen after completion of the patient's eighth and final dose of HDARAC.

dysarthria and ataxia

HDARAC

the patient's

seen


Input: Four weeks earlier she had developed hepatopathy during a regimen of carbamazepine, lynestrenol and sodium valproate.

she

hepatopathy

carbamazepine, lynestrenol and sodium valproate

developed


Input: We consider asterixis to be an easily overlooked sign of neurotoxicity, which may occur even at low or moderate dosage levels, if certain drugs as lithium or clozapine are used in combination with CBZ.

even at low or moderate dosage levels

certain drugs as lithium or clozapine are used in combination with CBZ

asterixis

may

occur


Input: We report here a rare case of pleuropericarditis due to methotrexate.

pleuropericarditis

methotrexate

a rare case

due


Input: A case of phenytoin-induced hepatitis with mononucleosis is reported, and syndromes associated with phenytoin hypersensitivity reactions are discussed.

phenytoin

hepatitis with mononucleosis

induced


Input: We also discuss whether screening for DPD deficiency is warranted to identify patients at risk for severe toxicities from 5-FU treatment.

5-FU treatment

severe toxicities

patients

severe

risk


Input: We report a case of reversible encephalopathy syndrome in a 16-year-old girl with acute myelogenous leukemia (AML), who is undergoing during consolidation chemotherapy composed of BH-AC (N4-behenoyl-1-beta-D-arabinofuranosyl cytosine) and idarubicin.

reversible encephalopathy syndrome

a 16-year-old girl with acute myelogenous leukemia (AML)

consolidation chemotherapy composed of BH-AC (N4-behenoyl-1-beta-D-arabinofuranosyl cytosine) and idarubicin

undergoing


Input: Concurrent use of vismodegib and warfarin was deemed the probable cause of acute INR elevation in this case, suggesting the need for close monitoring of INR values in patients receiving this combination of drugs.

vismodegib and warfarin

acute INR elevation

probable

cause


Input: Captopril is an angiotensin-converting enzyme (ACE) inhibitor and their cutaneous side-effects are documented, but little has been published concerning the usefulness of patch test when they occur.

cutaneous side-effects

Captopril

documented


Input: High-dose methylprednisolone in a pregnant woman with Crohn's disease and adrenal suppression in her newborn.

a pregnant woman with Crohn's disease

High-dose methylprednisolone

adrenal suppression in her newborn

in


Input: Cardiac hypersensitivity and myopericarditis have been reported during long-term treatment with mesalazine.

Cardiac hypersensitivity and myopericarditis

long-term treatment with mesalazine

reported


Input: It is concluded that 'cerebral atrophy' on CT scans may represent an accumulative effect of ACTH and that ACTH should be given with the utmost discretion, and in as low a dose as possible.

cerebral atrophy

ACTH

may

represent


Input: Two cases of polymorphic ventricular tachycardia induced by the administration of verapamil against paroxysmal supraventricular tachycardia.

polymorphic ventricular tachycardia

verapamil

induced


Input: Fatal acute encephalomyelitis after a single dose of intrathecal methotrexate.

Fatal acute encephalomyelitis

single dose of intrathecal methotrexate

Fatal

after


Input: The authors report one case of incomplete posterior hyaloid detachment (PHD) following intravitreal pegaptanib to treat DME.

incomplete posterior hyaloid detachment (PHD)

intravitreal pegaptanib

one case

following


Input: Pulmonary edema as a delayed complication of ritodrine therapy.

Pulmonary edema

ritodrine

complication


Input: Carbamazepine toxicity following Oxybutynin and Dantrolene administration: a case report.

Oxybutynin and Dantrolene

Carbamazepine toxicity

following


Input: Multiple seizures after bupropion overdose in a small child.

Multiple seizures

bupropion overdose

a small child

after


Input: Sorafenib, a multitargeted kinase inhibitor used for the treatment of unresectable hepatocellular carcinoma and advanced renal cell carcinomas, received FDA approval in 2005.

Sorafenib

a multitargeted kinase inhibitor

treatment


Input: Triiodothyronine-induced thyrotoxicosis in ophthalmic Graves disease.

Triiodothyronine

thyrotoxicosis

induced


Input: Bleomycin induced hyperpigmentation with yolk sac tumor.

Bleomycin

hyperpigmentation with yolk sac tumor

induced


Input: PURPOSE: To describe bilateral corneal endothelial dysfunction in a patient with Parkinson disease who was treated with long-term amantadine.

bilateral corneal endothelial dysfunction

a patient with Parkinson disease

long-term amantadine

in


Input: A case of severe acute hepatitis caused by cyproterone acetate in a 71 year old man with prostatic carcinoma is reported with a review of the literature on hepatic reactions to this drug.

acute hepatitis

cyproterone acetate

a 71 year old man with prostatic carcinoma

severe

caused


Input: Insulin-dependent diabetes mellitus associated with danazol.

danazol

Insulin-dependent diabetes mellitus

associated


Input: CONCLUSIONS: Topical brimonidine may be associated with central nervous system depression in infants.

Topical brimonidine

central nervous system depression

infants

may

associated


Input: Flecainide-associated pneumonitis with acute respiratory failure in a patient with the LEOPARD syndrome.

a patient with the LEOPARD syndrome

Flecainide

pneumonitis with acute respiratory failure

associated


Input: Seizure with hyponatremia in a child prescribed desmopressin for nocturnal enuresis.

desmopressin

Seizure with hyponatremia

a child

in


Input: Risks and benefits of co-treatment should be carefully considered and therapeutic alternatives to NSAIDs should be recommended to patients with central DI in order to improve DDAVP safety.

therapeutic alternatives to NSAIDs

patients with central DI

in order to improve DDAVP safety

recommended


Input: She had been treated by Carbamazepine 1000 mg/day for neuropathic pain for 2 years without clinical or laboratory signs of toxicity.

Carbamazepine 1000 mg/day

She

treated


Input: The chemotherapeutics, including vincristine, actinomycin D, and epirubicin in case 1 and vincristine and actinomycin D in case 2, were given before the hepatotoxicity developed.

vincristine and actinomycin D

hepatotoxicity developed

given

hepatotoxicity developed

chemotherapeutics, including vincristine, actinomycin D, and epirubicin

given


Input: After a second dose of metoclopramide, these symptoms recurred and were associated with confusion, agitation, fever, diaphoresis, tachypnea, tachycardia, and hypertension.

second dose of metoclopramide

confusion, agitation, fever, diaphoresis, tachypnea, tachycardia, and hypertension

associated


Input: We report the first case of tuberculous uveitis due to etanercept.

tuberculous uveitis

etanercept

due to


Input: Acute hyperphosphatemia caused by sodium phosphate enema in a patient with liver dysfunction and chronic renal failure.

Acute hyperphosphatemia

sodium phosphate enema

a patient with liver dysfunction and chronic renal failure

caused


Input: We discuss the association between carbamazepine and hyponatremia and the causes of hyponatremia after cardiopulmonary bypass.

carbamazepine

hyponatremia

association


Input: Use of the Naranjo adverse drug reaction probability algorithm indicated a probable relationship between serotonin syndrome and treatment with lithium and venlafaxine.

serotonin syndrome

treatment with lithium and venlafaxine

probable

a probable relationship between


Input: The exact mechanism of IVIG-associated acute renal failure remains unclear.

IVIG

acute renal failure

unclear

associated


Input: We report on 7 patients (2 women, 5 men) with chronic renal failure, who developed under a high dosage of the new diuretic muzolimine (range 240 to 1440 mg per day) fatal neuromyeloencephalopathy.

a high dosage of the new diuretic muzolimine (range 240 to 1440 mg per day)

fatal neuromyeloencephalopathy

7 patients (2 women, 5 men) with chronic renal failure

fatal

developed


Input: Two renal transplant patients developed anemia during treatment of hypertension with enalapril medication.

Two renal transplant patients

anemia

enalapril medication

developed


Input: Sotalol-induced bradycardia reversed by glucagon.

glucagon

reversed

Sotalol

bradycardia

induced


Input: The development of cutaneous ecchymosis associated with a sudden fall in hemoglobin after the administration of alteplase should strongly suggest the possibility of diffuse subfascial hematoma.

cutaneous ecchymosis

a sudden fall in hemoglobin

diffuse subfascial hematoma

alteplase

strongly sugges

development


Input: We report a case of papillary necrosis in a patient treated with indinavir.

papillary necrosis

indinavir

a patient

treated


Input: Generalized maculopapular and papular purpuric eruptions are perhaps the most common thionamide-induced reactions.

Generalized maculopapular and papular purpuric eruptions

reactions

thionamide

perhaps

induced


Input: Imidazoline intoxication due to overdose or accidental ingestion but also after normal therapeutic usage is frequent in children.

children

Imidazoline

overdose or accidental ingestion but also after normal therapeutic usage

intoxication

due


Input: A 50-year-old diabetic and hypertensive male patient is reported who had ticlopidine-induced marrow aplasia partially responsive to colony-stimulating factors and corticosteroids, but experienced complete recovery with cyclosporine.

ticlopidine

50-year-old diabetic and hypertensive male patient

marrow aplasia

induced

50-year-old diabetic and hypertensive male patient

experienced complete recovery

cyclosporine

with


Input: A patient with intracranial osteosarcoma that arose 16 years after radiation therapy for hereditary retinoblastoma developed fatal cerebral edema and brainstem herniation after she received a single dose of intravenous methotrexate.

a single dose of intravenous methotrexate

cerebral edema and brainstem herniation

A patient with intracranial osteosarcoma that arose 16 years after radiation therapy for hereditary retinoblastoma

fatal

developed


Input: Neutropenia is an infrequent complication following administration of the angiotensin-converting enzyme (ACE) inhibitor, captopril.

Neutropenia

the angiotensin-converting enzyme (ACE) inhibitor, captopril

following


Input: INTRODUCTION: We describe the neurointensive care (NIC) management of a patient with severe cerebral swelling and raised intracranial pressure (ICP) after severe sodium valproic acid (VPA) intoxication.

patient

severe cerebral swelling and raised intracranial pressure (ICP)

intoxication

sodium valproic acid (VPA)

severe

after


Input: Lithium therapy was discontinued because of poor compliance to the medication and intolerable polyuria.

Lithium

polyuria

because


Input: Both PAN and methotrexate have been independently demonstrated to cause sensorineural hearing loss.

sensorineural hearing loss

PAN and methotrexate

cause


Input: CONCLUSION: A 26-year-old man with bipolar disorder developed hyperammonemia three weeks after initiating carbamazepine therapy.

A 26-year-old man with bipolar disorder

hyperammonemia

three weeks after initiating carbamazepine therapy

developed


Input: We report two adults who received gabapentin (GBP) and subsequently developed behavioural side effects.

gabapentin (GBP)

behavioural side effects

two adults

developed


Input: Atrial fibrillation was induced by diltiazem in two patients and verapamil induced syncope in one patient.

diltiazem

two patients

Atrial fibrillation

induced

verapamil

syncope

one patient

induced


Input: We can conclude that in this case, as in many others, akathisia as a possible adverse effect of psychopharmacs was very hard to identify.

psychopharmacs

akathisia

this case

possible

adverse effect


Input: Although HAART is very important in the treatment of HIV, its side effects are responsible for patients' non-adherence to medications.

HAART

non-adherence to medications

patients

side effects


Input: A case of acute subdural haematoma originating spontaneously from an angiomatous meningioma in a patient receiving prophylactic aspirin therapy is presented.

acute subdural haematoma

an angiomatous meningioma in a patient

aspirin

presented


Input: Long known to psychiatrists, monoamine oxidase inhibitors (MAOIs) and complications of their use may be unfamiliar to medical and surgical practitioners who may thus unwittingly precipitate a hypertensive crisis or serotonin syndrome.

monoamine oxidase inhibitors (MAOIs)

hypertensive crisis or serotonin syndrome

precipitate


Input: According to the Naranjo adverse drug reaction probability scale, the likelihood that temozolomide was responsible for the adverse drug reaction of fever was probable (score of 6).

temozolomide

fever

probable

adverse drug reaction


Input: OBJECTIVE: To describe the development of valproate-related reproductive endocrine disorders in women with epilepsy.

women with epilepsy

reproductive endocrine disorders

valproate

related


Input: Alprazolam-induced mania: two clinical cases.

Alprazolam

mania

two clinical cases

induced


Input: Bronchiolitis obliterans organising pneumonia associated with the use of nitrofurantoin.

use of nitrofurantoin

Bronchiolitis obliterans organising pneumonia

associated with


Input: To our knowledge, this recurrence of amiodarone pulmonary toxicity has not been reported previously.

amiodarone

pulmonary toxicity

toxicity


Input: A patient treated with itraconazole (ITCZ) under the diagnosis of Aspergillus flavus-induced chronic hypertrophic pachymeningitis is presented.

A patient

itraconazole (ITCZ)

treated


Input: Severe autoimmune hemolytic anemia following rituximab therapy in a patient with a lymphoproliferative disorder.

Severe autoimmune hemolytic anemia

rituximab therapy

a patient with a lymphoproliferative disorder

following


Input: The renal consequences of indinavir-associated nephrotoxicity are uncertain.

indinavir

nephrotoxicity

uncertain

associated


Input: BACKGROUND: reports on delated cutaneous reactions to captopril have been seldom reported.

captopril

delated cutaneous reactions

reported


Input: Bismuth subsalicylate 30 mL every 4 hours was prescribed for diarrhea.

Bismuth subsalicylate 30 mL every 4 hours

prescribed


Input: A drug interaction between the alpha(2)-adrenergic agonist medetomidine and lignocaine is suspected and highlights the potential for seizures following the subcutaneous administration of relatively large doses of lignocaine under medetomidine sedation.

seizures

subcutaneous administration of relatively large doses of lignocaine under medetomidine sedation

potential

following


Input: Oesophageal ulceration due to emepronium bromide.

Oesophageal ulceration

emepronium bromide

due to


Input: Development of sarcoidosis during interferon alpha 2b and ribavirin combination therapy for chronic hepatitis C--a case report and review of the literature.

sarcoidosis

interferon alpha 2b and ribavirin

Development


Input: CONCLUSION: The findings in these two patients suggest that colchicine may delay corneal wound healing.

delay corneal wound healing

colchicine

two patients

may

delay


Input: Gemcitabine-associated hemolytic-uremic syndrome.

Gemcitabine

hemolytic-uremic syndrome

associated


Input: Case study: adverse response to clonidine.

adverse response

clonidine

to


Input: In this report, a patient who had undergone a renal transplantation as a result of malignant hypertension, and who was on immunosuppressive therapy consisting of cyclosporin, prednisone and azathioprine, developed thrombosis of the central retinal vein 5 years following the transplantation.

thrombosis of the central retinal vein

a patient

on immunosuppressive therapy consisting of cyclosporin, prednisone and azathioprine

undergone a renal transplantation as a result of malignant hypertension

developed


Input: In each of the three reported patients, alteration of eyelid appearance with deepening of the lid sulcus was evident as the result of topical bimatoprost therapy.

topical bimatoprost

three reported patients

alteration of eyelid appearance with deepening of the lid sulcus

evident


Input: PURPOSE: To report a case of traumatic flap dehiscence and Enterobacter keratitis 34 months after LASIK.

34 months after LASIK

traumatic flap dehiscence and Enterobacter keratitis

after


Input: CONCLUSIONS: The risk of drug-induced rhabdomyolysis due to the potential interaction between lovastatin and azithromycin or clarithromycin should be considered before the concomitant use of these agents.

rhabdomyolysis

lovastatin

azithromycin

clarithromycin

due


Input: Ten years of behavioral data are presented to support the hypothesis that phenobarbital was exacerbating maladaptive behaviors.

phenobarbital

maladaptive behaviors

exacerbating


Input: Terbinafine-induced cholestatic liver disease.

Terbinafine

cholestatic liver disease.

induced


Input: The proteasome inhibitor Bortezomib has been identified as a potent enhancer of TRAIL-induced apoptosis in several human cancers.

apoptosis in several human cancers

proteasome inhibitor Bortezomib has been identified as a potent enhancer of TRAIL

induced


Input: METHODS: A retrospective report of the first case of gemcitabine-related HUS, in a patient with metastatic pancreatic adenocarcinoma, treated with a variety of standard therapies in addition to rituximab is presented.

gemcitabine

HUS

a patient with metastatic pancreatic adenocarcinoma

related


Input: Their parkinsonism improved on discontinuation of metoclopramide therapy.

discontinuation of metoclopramide therapy

Their parkinsonism

improved


Input: Lichen planus induced by hepatitis B vaccination: a new case and review of the literature.

Lichen planus

hepatitis B vaccination

induced


Input: A total of 40 healthy volunteers were planned to start with 600 mg rifampicin once daily from days 1-5.

40 healthy volunteers

600 mg rifampicin once daily from days 1-5

start


Input: Skin necrosis secondary to low-molecular weight heparin in a patient with antiphospholipid antibody syndrome.

a patient with antiphospholipid antibody syndrome

Skin necrosis

low-molecular weight heparin

secondary to


Input: Exacerbation of anthracycline-induced early chronic cardiomyopathy with ATRA: role of B-type natriuretic peptide as an indicator of cardiac dysfunction.

anthracycline

with ATRA

early chronic cardiomyopathy

induced


Input: Fixed drug eruption in hands caused by omeprazole.

omeprazole

Fixed drug eruption in hands

caused


Input: FK506, which began to be administered 12 days earlier, rose to a level of 44 ng/mL (normal range, 10-20 ng/mL) 1 day before neurologic abnormalities began.

FK506, which began to be administered 12 days earlier, rose to a level of 44 ng/mL (normal range, 10-20 ng/mL)

neurologic abnormalities began

before


Input: Sweet's syndrome is an acute febrile neutrophilic dermatosis that is a known complication of the administration of filgrastim, a drug that causes increased neutrophil proliferation and differentiation.

filgrastim

Sweet's syndrome is an acute febrile neutrophilic dermatosis

increased neutrophil proliferation and differentiation

causes


Input: Although it would be expected that, like other type IA toxicities, diphenhydramine-induced cardiotoxicity could be responsive to hypertonic sodium bicarbonate, this finding is largely unappreciated.

diphenhydramine

cardiotoxicity

induced

hypertonic sodium bicarbonate

could

responsive


Input: We describe a patient who experienced chronic nausea and an episode of confusion while treated with a small, stable dose of oral morphine in the setting of mild renal insufficiency.

a patient

chronic nausea and an episode of confusion

a small, stable dose of oral morphine

experienced


Input: Bulbar and pseudobulbar palsy complicating therapy with high-dose cytosine arabinoside in children with leukemia.

children with leukemia

Bulbar and pseudobulbar palsy

high-dose cytosine arabinoside

complicating


Input: The development of erythroid leukemia plus carcinoma in these two men suggests mutagenic change secondary to cyclophosphamide therapy.

cyclophosphamide therapy

development of erythroid leukemia plus carcinoma

mutagenic change

two men

suggests


Input: Administration of thiazide diuretics also has been the cause of hyponatremia.

thiazide diuretics

hyponatremia

cause


Input: Serotonin syndrome is a potentially lethal adverse drug reaction that may occur in patients taking proserotoninergic medications.

Serotonin syndrome

patients

proserotoninergic medications

lethal

may

occur


Input: However, there remain questions concerning whether these drugs, especially methimazole (MMI), may be associated with aplasia cutis congenita (ACC) and how best to avoid impairment of fetal thyroid function during their use.

methimazole

aplasia cutis congenita

questions

associated


Input: An 18-year-old man with attention-deficit-hyperactivity disorder (ADHD) was prescribed varenicline for smoking cessation.

An 18-year-old man with attention-deficit-hyperactivity disorder (ADHD)

varenicline

prescribed


Input: The condition should be suspected in patients who develop unexplained abdominal pain or collapse following vasopressin treatment.

patients

unexplained abdominal pain or collapse

vasopressin

suspected

develop


Input: The present observation suggests, that a batch of different testing doses, including lower testing doses may help to differentiate between an allergic type of contact dermatitis and an irritant type of reaction after treatment with calcipotriol.

calcipotriol

an allergic type of contact dermatitis

an irritant type of reaction

may

after treatment


Input: Acute erythroid leukemia after cyclophosphamide therapy for multiple myeloma: report of two cases.

Acute erythroid leukemia

cyclophosphamide therapy

two cases

after


Input: A combination of behavioural and cognitive adverse effects is illustrated in this case report of a recurrent triazolam-induced eating disorder.

triazolam

eating disorder

induced


Input: 5-fluorouracil (5-FU)-associated peripheral neuropathy is an uncommon event.

peripheral neuropathy

associated


Input: Insulin-induced lipoatrophy in type I diabetes.

Insulin

lipoatrophy

induced


Input: This article describes a patient with suspected ciprofloxacin-induced interstitial nephritis.

ciprofloxacin

a patient

interstitial nephritis

suspected

induced


Input: We report 3 cases of HIV-1 infected patients who experienced symptomatic angiolipomas shortly after starting antiretroviral therapy including the protease inhibitor indinavir.

3 cases of HIV-1 infected patients

symptomatic angiolipomas

antiretroviral therapy including the protease inhibitor indinavir

shortly after

experienced


Input: Depressive symptoms disappeared after interferon therapy was stopped.

interferon therapy

Depressive symptoms

after


Input: Coumarin is reported to elevate liver function tests (LFT) values.

Coumarin

elevate liver function tests (LFT) values

reported


Input: Decreased plasma cortisol level during alprazolam treatment of panic disorder: a case report.

Decreased plasma cortisol level

alprazolam

during


Input: Severe diffuse interstitial pneumonitis induced by carmustine (BCNU).

diffuse interstitial pneumonitis

carmustine (BCNU)

Severe

induced


Input: Fever, pulmonary infiltrates, and pleural effusion following acyclovir therapy for herpes zoster ophthalmicus.

Fever, pulmonary infiltrates, and pleural effusion

acyclovir therapy for herpes zoster ophthalmicus

following


Input: We propose a mechanism of vancomycin-induced mast cell degranulation and subsequent release of eosinophil chemotactic factor as a cause of CSFE.

mast cell degranulation and subsequent release of eosinophil chemotactic factor as a cause of CSFE

vancomycin

propose

induced


Input: Within 3 weeks of beginning continuous daily isoniazid and rifampin therapy for pulmonary tuberculosis, a patient developed acute renal failure.

Within 3 weeks of beginning continuous daily isoniazid and rifampin

a patient

acute renal failure

developed


Input: We report four cases of severe corneal ulceration in methamphetamine abusers.

four cases

corneal ulceration

methamphetamine

severe

in


Input: Diagnosis: practolol induced sclerosing peritonitis.

practolol

sclerosing peritonitis

induced


Input: We report the first biopsy confirmed occurrence of acute interstitial nephritis in a patient receiving treatment with Sunitinib for metastatic renal cell cancer.

acute interstitial nephritis

patient

Sunitinib

occurrence


Input: Multiple pulmonary nodules: an unusual presentation of fludarabine pulmonary toxicity: case report and review of literature.

Multiple pulmonary nodules

fludarabine

presentation


Input: Clozapine-induced tardive dyskinesia in schizophrenic patients taking clozapine as a first-line antipsychotic drug.

schizophrenic patients

Clozapine

tardive dyskinesia

induced


Input: Recently, her serum theophylline levels had increased to the toxic range (133.2 micromol/L [24 microg/mL]) shortly after the addition of zafirlukast (Accolate, Zeneca Pharmaceuticals, Wilmington, Del) to her regimen.

theophylline levels had increased to the toxic range

zafirlukast

her

after


Input: Withdrawal emergent syndrome in an infant associated with maternal haloperidol therapy.

Withdrawal emergent syndrome

an infant

maternal haloperidol therapy

associated


Input: Diphenylhydantoin apparently adversely affected both the clinical and biochemical parameters of the acute intermittent porphyria.

Diphenylhydantoin

adversely affected both the clinical and biochemical parameters of the acute intermittent porphyria

affected


Input: Successful recovery from interstitial pneumonitis, induced by bicalutamide and leuprorelin acetate given as treatment for prostate cancer.

bicalutamide and leuprorelin acetate

interstitial pneumonitis

induced


Input: Gold-induced pneumonitis.

Gold

pneumonitis

induced


Input: OBJECTIVE: To report a case of significant hepatic and renal failure with the use of argatroban in a patient with heparin-induced thrombocytopenia (HIT) requiring continuous veno-veno hemodialysis (CVVHD).

significant hepatic and renal failure

argatroban

a patient with heparin-induced thrombocytopenia (HIT) requiring continuous veno-veno hemodialysis (CVVHD)

significant

use

heparin

thrombocytopenia

induced


Input: Visceral leishmaniasis and macrophagic activation syndrome in a patient with rheumatoid arthritis under treatment with adalimumab.

adalimumab

Visceral leishmaniasis and macrophagic activation syndrome

a patient with rheumatoid arthritis

under


Input: He was diagnosed with possible serotonin syndrome; his symptoms resolved after clomipramine was stopped but before clozapine was restarted eight days later.

possible serotonin syndrome

clozapine

He

resolved


Input: Disseminated intravascular coagulation associated with acute hemoglobinemia or hemoglobinuria following Rh(0)(D) immune globulin intravenous administration for immune thrombocytopenic purpura.

Rh(0)(D) immune globulin intravenous

Disseminated intravascular coagulation associated with acute hemoglobinemia or hemoglobinuria

following


Input: Two patients had ampicillin-associated seizures.

ampicillin

seizures

associated


Input: A patient developed restless legs symptoms paralleling the course of interferon-alpha (IFN alpha) therapy for chronic hepatitis C.

A patient

restless legs symptoms

interferon-alpha (IFN alpha) therapy

developed


Input: While many can benefit from coadministration of serotonergic antidepressants and opioids, it appears that some individuals are at increased risk for SS.

SS

some individuals

coadministration of serotonergic antidepressants and opioids

risk


Input: Stomatitis, diarrhea, dermatitis, and myelosuppression are the main toxicities of 5-FU.

diarrhea

dermatitis

myelosuppression

Stomatitis

toxicities


Input: After treatment with cimetidine, there was a rapid deterioration with decreased oxygen saturation and arterial PO2 values.

cimetidine

a rapid deterioration with decreased oxygen saturation and arterial PO2 values

was


Input: We describe a case of advanced ovarian carcinoma who developed difficulty walking because of marked pain in the lower extremities and loss of proprioception 25 days after treatment with weekly taxol (80 mg/m(2)x3).

difficulty walking because of marked pain in the lower extremities and loss of proprioception

25 days after treatment with weekly taxol (80 mg/m(2)x3)

a case of advanced ovarian carcinoma

marked

developed


Input: Agranulocytosis and granulocytopenia associated with quetiapine.

Agranulocytosis and granulocytopenia

quetiapine

associated


Input: The multiple comedones and ruptured epidermoid cysts are newly reported adverse effects of imiquimod therapy.

multiple comedones and ruptured epidermoid cysts

imiquimod therapy

reported


Input: We conclude that neurosurgeons and neurologists should be aware of calcium antagonist--related ileus in patients treated with nimodipine.

calcium antagonist

nimodipine

ileus

patients

related


Input: Hyperpigmentation during interferon-alpha therapy for chronic hepatitis C virus infection.

Hyperpigmentation

interferon-alpha therapy

during


Input: Chlorambucil-induced chromosome damage to human lymphocytes is dose-dependent and cumulative.

Chlorambucil

chromosome damage

induced


Input: Carbamazepine hypersensitivity syndrome is a rare, life-threatening condition.

Carbamazepine

hypersensitivity syndrome

is


Input: Case report: dapsone hypersensitivity syndrome associated with treatment of the bite of a brown recluse spider.

dapsone

hypersensitivity syndrome

associated


Input: Acute asymptomatic hepatitis in a healthy normal volunteer exposed to 2 oral doses of amodiaquine and artesunate.

Acute asymptomatic hepatitis

a healthy normal volunteer

2 oral doses of amodiaquine and artesunate

exposed


Input: The authors report a case of focal myocardial necrosis, presenting clinically as an acute myocardial infarction during the administration of the antineoplastic drug, amsacrine, in a patient without coronary artery disease.

a patient without coronary artery disease

amsacrine

focal myocardial necrosis, presenting clinically as an acute myocardial infarction

during


Input: Baclofen and oxazepam were prescribed secondary to right-sided hemiparesis contractures.

oxazepam

Baclofen

prescribed


Input: DISCUSSION: A review of the cases of SS with implication of mirtazapine as the cause was performed.

mirtazapine

SS

implication of


Input: A small number of oxaliplatin-related hemolytic and/or thrombocytopenic reactions have been reported.

oxaliplatin

hemolytic and/or thrombocytopenic reactions

related


Input: CASE SUMMARY: A 39-year-old white Jewish schizophrenic man treated with olanzapine developed an elevated serum CK concentration with a peak concentration of 4000 IU/L (normal < 230).

A 39-year-old white Jewish schizophrenic man

an elevated serum CK concentration

olanzapine

developed


Input: Severe water intoxication secondary to the concomitant intake of non-steroidal anti-inflammatory drugs and desmopressin: a case report and review of the literature.

Severe water intoxication

the concomitant intake of non-steroidal anti-inflammatory drugs and desmopressin

Severe

secondary to


Input: An apparent link is described between the use of MMF with prednisone to treat pemphigus vulgaris and the development of red blood cell anemia.

red blood cell anemia

MMF with prednisone to treat pemphigus vulgaris

apparent

development


Input: Other potential causes of renal failure were not present in our patient and his renal function gradually recovered with the cessation of suramin treatment.

cessation of suramin treatmen

our patient

his renal function gradually recovered

recovered


Input: Massive CBZ OD may produce a reversible encephalopathy that includes cortical hyperexcitability, a profound burst-suppression EEG pattern, and cranial nerve areflexia.

Massive CBZ OD

reversible encephalopathy that includes cortical hyperexcitability, a profound burst-suppression EEG pattern, and cranial nerve areflexia

may

produce


Input: This is the first report of a fluoxetine-related death in a child with a confirmed genetic polymorphism of the CYP2D6 gene that results in impaired drug metabolism.

fluoxetine

death

a child with a confirmed genetic polymorphism of the CYP2D6 gene that results in impaired drug metabolism

related


Input: We report a case of reversible DKA and new-onset DM that developed in a demented patient who was treated with quetiapine for 14 days.

quetiapine for 14 days

demented patient

reversible DKA and new-onset DM

developed


Input: We describe 3 cases of diphenhydramine-induced cardiac toxicity that were responsive to bicarbonate.

diphenhydramine

cardiac toxicity

3 cases

induced

3 cases

bicarbonate

responsive


Input: The patient's arthritis flared after the second infusion of infliximab, which was discontinued.

arthritis flared

patient's

second infusion of infliximab

after


Input: CONCLUSION: Marked visual field constriction appears to be associated with vigabatrin therapy.

Marked visual field constriction

vigabatrin therapy

associated


Input: Possible serotonin syndrome associated with clomipramine after withdrawal of clozapine.

serotonin syndrome associated with clomipramine

withdrawal of clozapine

Possible

after


Input: A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy.

A 14-year-old female

systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA)

administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy

developed


Input: There was a clear relationship between restarting the Accutane and recurrence of the transient myopia.

Accutane

recurrence of the transient myopia

a clear relationship


Input: Graves' hyperthyroidism following transient thyrotoxicosis during interferon therapy for chronic hepatitis type C.

Graves' hyperthyroidism following transient thyrotoxicosis

interferon therapy

during


Input: Masculinization of a female fetus occurred in 5 of 39 (12.8%) exposed to norethisterone; all were cases of clitoral hypertrophy not requiring surgical treatment.

Masculinization of a female fetus

clitoral hypertrophy

5 of 39 (12.8%)

norethisterone

not requiring surgical treatment

exposed


Input: She continued taking verapamil for 6 months, then, on her own, stopped all medications including the sustained-release verapamil, and her asthma symptoms disappeared.

She

continued taking verapamil for 6 months, then, on her own, stopped all medications including the sustained-release verapamil

disappeared


Input: Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.

cisplatin

involving intrahepatic artery infusion

one

manifested general erythema, dyspnea, and hypotension

reactions

the other

cisplatin

involving intravenous infusion

manifested abdominal pain, general erythema, and fever

reactions


Input: CONCLUSION: There are only a few confirmed cases of gemcitabine-associated HUS despite the widespread use of the drug.

gemcitabine

HUS

few

associated


Input: In these patients, long-acting octreotide may trigger serious hypoglycemia.

these patients

long-acting octreotide

serious hypoglycemia

trigger


Input: Usefulness of antiplatelet drugs in the management of heparin-associated thrombocytopenia and thrombosis.

heparin

thrombocytopenia and thrombosis

associated

antiplatelet drugs

Usefulness


Input: An intertrigo-like eruption from pegylated liposomal doxorubicin.

pegylated liposomal doxorubicin

intertrigo-like eruption

from


Input: We report a case of NEH masquerading as cutaneous vasculitis in a woman receiving cyclophosphamide for lupus nephritis.

cyclophosphamide

NEH masquerading as cutaneous vasculitis

a woman

for lupus nephritis

in


Input: The diagnosis of hypothermia was delayed until it was apparent for several days but resolved with the discontinuation of risperidone and continuation of clozapine.

discontinuation of risperidone and continuation of clozapine

resolved


Input: Unaccountable severe hypercalcemia in a patient treated for hypoparathyroidism with dihydrotachysterol.

dihydrotachysterol

Unaccountable severe hypercalcemia

patient

treated


Input: Anaphylaxis to calcitonin.

Anaphylaxis

calcitonin

to


Input: However, he developed acute renal failure, hyperkalemia, and hyperuricemia 30 d after receiving the sorafenib treatment.

he

sorafenib

acute renal failure, hyperkalemia, and hyperuricemia

developed


Input: Mycobacterium marinum infection complicating Crohn's disease, treated with infliximab.

infliximab

treated


Input: Current immunosuppressive therapies are effective but can be associated with significant adverse reactions.

Current immunosuppressive therapies

significant adverse reactions.

can be

associated


Input: This report describes the first association (exclusive of drug overdose) of symptomatic torsades de pointes occurring with the use of terfenadine in a patient who was taking the recommended prescribed dose of this drug in addition to cefaclor, ketoconazole, and medroxyprogesterone.

terfenadine

taking the recommended prescribed dose of this drug in addition to cefaclor, ketoconazole, and medroxyprogesterone

symptomatic torsades de pointes

a patient

occurring


Input: Tamoxifen is suggested to be carcinogenic both through direct genotoxic and epigenetic mechanisms.

Tamoxifen

carcinogenic both through direct genotoxic and epigenetic mechanisms

suggested


Input: DISCUSSION: Colchicine, the most important drug in treatment of FMF, can cause myopathy in patients with impaired renal and hepatic function.

Colchicine

myopathy

patients with impaired renal and hepatic function

cause


Input: In the presented case fluvoxamine-induced akathisia in an OCD patient was partially resistant to the anticholinergic agent biperiden, and was successfully treated with the 5-HT2A/5-HT2C antagonist mianserin.

fluvoxamine-induced akathisia in an OCD patient

5-HT2A/5-HT2C antagonist mianserin

treated


Input: SUBSEQUENT COURSE: The nephrosis resolved almost completely once the interferon was stopped and after immunosuppressive treatment.

interferon was stopped and after immunosuppressive treatment

resolved


Input: In two patients, apomorphine remained effective in the morning, but increased the intensity of the dyskinesias in the afternoon.

In two patients

apomorphine

intensity of the dyskinesias in the afternoon

increased


Input: Transient asymptomatic bradycardia in patients on infusional 5-fluorouracil.

infusional 5-fluorouracil.

Transient asymptomatic bradycardia

patients

Transient

on


Input: In 2006, he was diagnosed with deep vein thrombosis and pulmonary embolism and was started on warfarin.

he

warfarin

started


Input: Scleritis complicating zoledronic acid infusion.

Scleritis

zoledronic acid infusion

complicating


Input: A 22-year-old black man developed fever, chills, fatigue, night sweats, tender lymphadenopathy, and a generalized, pruritic, macular eruption 3 weeks after starting minocycline therapy for acne.

fever, chills, fatigue, night sweats, tender lymphadenopathy, and a generalized, pruritic, macular eruption

minocycline therapy

A 22-year-old black man

developed


Input: Ticlopidine-induced aplastic anemia: two new case reports, review, and meta-analysis of 55 additional cases.

Ticlopidine

aplastic anemia

induced


Input: This is the second report of acute lung injury and diffuse alveolar damage caused by mefloquine.

acute lung injury and diffuse alveolar damage

mefloquine

caused


Input: A case of Erythema Multiforme Bullosum in patient of lepromatous leprosy with pulmonary tuberculosis due to Rifampicin is described.

Erythema Multiforme Bullosum

patient of lepromatous leprosy with pulmonary tuberculosis

Rifampicin

due to


Input: Life-threatening alterations in heart rate after the use of adenosine in atrial flutter.

adenosine

Life-threatening alterations in heart rate

Life-threatening

after


Input: We report a case of pancytopenia in a 23-year-old man with Crohn's disease who was treated with 5-aminosalicylic acid (Pentasa; Nisshin, Tokyo, Japan) 3.0 g/day.

a 23-year-old man with Crohn's disease

pancytopenia

5-aminosalicylic acid (Pentasa; Nisshin, Tokyo, Japan) 3.0 g/day

treated with


Input: The ampicillin rash occurring in cases of infectious mononucleosis is well documented.

The ampicillin rash

ampicillin

occurring


Input: The major side effect of infliximab is infection.

infliximab

infection

of


Input: An asymptomatic HIV-infected woman experienced right-sided renal colicky pain during treatment with indinavir.

An asymptomatic HIV-infected woman

right-sided renal colicky pain

indinavir

experienced


Input: The case resembles two previously reported cases of optic neuropathy which occurred in patients with Wilson's disease who were receiving penicillamine.

optic neuropathy

patients with Wilson's disease

penicillamine

occurred


Input: Cutaneous ulceration: an unusual complication of intravenous pentamidine therapy.

Cutaneous ulceration

intravenous pentamidine

unusual

complication


Input: Pulmonary hemorrhage is an uncommon feature in the HUS, and seems to appear especially in the HUS associated with MMC therapy.

Pulmonary hemorrhage

MMC

appear


Input: Immunosuppression elicited by the extensive administration of prednisolone was suspected for the initiation of the generalized mite infestation.

extensive administration of prednisolone

mite infestation

generalized


Input: The episode appeared to have been precipitated by toxicity due to ingestion of a large amount of phenytoin.

a large amount of phenytoin.

The episode appeared to have been precipitated by toxicity

due


Input: Cardiopulmonary arrest following intravenous phenytoin loading.

Cardiopulmonary arrest

intravenous phenytoin loading

following


Input: Although taxol has shown significant activity in advanced ovarian cancer, peripheral neuropathy is likely to become the major dose-limiting toxicity.

taxol

peripheral neuropathy

toxicity


Input: Syringotropic hypersensitivity reaction associated with infliximab and leflunomide combination therapy in a child with psoriatic arthritis.

Syringotropic hypersensitivity reaction

infliximab and leflunomide combination therapy

a child with psoriatic arthritis

associated


Input: Corticosteroid therapy was continued for 8 months since there was still improvement of pulmonary function studies.

Corticosteroid

for 8 months

improvement


Input: OBJECTIVE: To describe a case of sertraline-induced rhabdomyolysis in an elderly patient with dementia and comorbidities.

sertraline

rhabdomyolysis

an elderly patient with dementia and comorbidities

induced


Input: Beyond the predictable pharmacokinetic drug-drug interaction requiring a significant warfarin dose reduction, the iodine-rich amiodarone affects the thyroid gland, causing overt hypothyroidism or thyrotoxicosis in 14%-18% of cases.

iodine-rich amiodarone

overt hypothyroidism or thyrotoxicosis

causing


Input: Toxic epidermal necrolysis associated with interleukin-2.

Toxic epidermal necrolysis

associated


Input: The pulmonary toxicity of gold salts is an uncommon cause of life-threatening respiratory failure.

pulmonary toxicity

life-threatening respiratory failure

gold salts

cause


Input: With its characteristics, tizanidine has the potential to compromise hemodynamic stability during concomitant angiotensin-converting enzyme inhibitor use.

tizanidine

during concomitant angiotensin-converting enzyme inhibitor use

compromise hemodynamic stability

potential

compromise


Input: Premature closure of the ductus arteriosus: variable response among monozygotic twins after in utero exposure to indomethacin.

monozygotic twins

in utero exposure to indomethacin

Premature closure of the ductus arteriosus

after


Input: Possible mechanisms by which clonidine decreases spasticity are described, probable mechanisms of induced bradycardia are reviewed, and specific treatment recommendations for the use of clonidine in spinal cord injured patients are presented.

clonidine

bradycardia

induced


Input: This is the first report of a possible association between an acute cardiovascular event and venlafaxine.

an acute cardiovascular event

venlafaxine

possible

association


Input: Since early symptoms of the toxic effects of theophylline can mimic peptic ulcer disease, cimetidine might be prescribed for the gastrointestinal symptoms with subsequent worsening of theophylline poisoning.

cimetidine

might

prescribed


Input: Acute renal failure in a patient receiving treatment with suramin.

Acute renal failure

a patient

suramin

in


Input: A further case of anaphylactoid reaction to methylprednisolone is reported.

anaphylactoid reaction

methylprednisolone

to


Input: Pulmonary hemorrhage as a clinical manifestation of hemolytic-uremic syndrome associated with mitomycin C therapy.

Pulmonary hemorrhage

hemolytic-uremic syndrome

mitomycin C therapy

associated


Input: EEG abnormalities were observed in two of the nine children during chlorambucil therapy.

chlorambucil

EEG abnormalities

two of the nine children

observed


Input: Discontinuation of the itraconazole caused resolution of the drug eruption.

itraconazole

drug eruption

caused


Input: The addition of intrathecal methotrexate to treatment protocols has increased survival rates in children with acute lymphoblastic leukemia but is also associated with varying degrees of neurotoxicity.

varying degrees of neurotoxicity

The addition of intrathecal methotrexate to treatment protocols

in children with acute lymphoblastic leukemia

associated


Input: We conclude that the presence of this metabolic defect combined with topical 5-FU (a drug demonstrating a narrow therapeutic index) results in the unusual presentation of life-threatening toxicity after treatment with a topical drug.

unusual presentation of life-threatening toxicity

topical 5-FU (a drug demonstrating a narrow therapeutic index)

this metabolic defect

life-threatening

results in


Input: Six patients with rheumatoid arthritis developed a syndrome resembling lupus erythematosus while being treated with penicillamine.

Six patients with rheumatoid arthritis

syndrome resembling lupus erythematosus

penicillamine

developed


Input: This case highlights the need to monitor liver enzymes in patients treated with 6-TG and identifies the need for additional research focused on the mechanism of thiopurine-induced hepatic injury.

thiopurine

hepatic injury

patients treated with 6-TG

induced


Input: During clarithromycin coadministration, four out of the seven patients developed moderate-to-severe toxic symptoms of carbamazepine, such as drowsiness, dizziness, and ataxia, which resolved within 5 days after clarithromycin discontinuation.

four out of the seven patients

During clarithromycin coadministration

carbamazepine

moderate-to-severe toxic symptoms of carbamazepine, such as drowsiness, dizziness, and ataxia

severe

developed

5 days after clarithromycin discontinuation

resolved


Input: 5-Fluorouracil (5-FU) is an analogue of pyrimidine nucleosides that is widely used in the treatment of head and neck, breast, ovarian, and colon cancer.

5-Fluorouracil (5-FU) is an analogue of pyrimidine nucleosides

used


Input: Fulminant fatal cardiotoxicity following cyclophosphamide therapy.

cyclophosphamide

Fulminant fatal cardiotoxicity

following


Input: The reaction in our patient appeared after tizanidine initiation and improved after both lisinopril and tizanidine were discontinued.

tizanidine initiation

patient

reaction

after

patient

both lisinopril and tizanidine

improved


Input: We describe the exceptional development of AML and lung cancer in a patient with previously diagnosed CLL in minimal residual disease status after fludarabine treatment followed by autologous peripheral blood stem-cell transplantation.

fludarabine

autologous peripheral blood stem-cell transplantation

AML

lung cancer

a patient with previously diagnosed CLL in minimal residual disease status

development


Input: Valproate-induced hyperammonemia as a cause of altered mental status.

Valproate

altered mental status

hyperammonemia

induced


Input: We report 5 cases of acute reversible renal failure coinciding with the onset of treatment with captopril in patients with severe drug-resistant hypertension.

captopril

patients with severe drug-resistant hypertension

acute reversible renal failure

acute

onset of treatment


Input: We report a case of contact dermatitis due to sodium bisulfite in Tathion eye drops.

contact dermatitis

sodium bisulfite

due


Input: The first patient is undergoing hemodialysis and, though responding to sunitinib, is having significant fatigue and hypertension.

sunitinib

The first patient

significant fatigue and hypertension

having


Input: CCBs should be considered in the treatment of 5-FU or capecitabine-induced headaches.

CCBs

treatment


Input: Furosemide, spironolactone, allopurinol, and hydroxyurea were considered possible causes of the reaction and were discontinued.

Furosemide, spironolactone, allopurinol, and hydroxyurea

reaction

causes


Input: PATIENTS: One patient with mucositis secondary to chemotherapy.

chemotherapy

mucositis

One patient

secondary


Input: A patient with monocular open-angle glaucoma had trichiasis, a condition associated with the use of a prostaglandin analog.

A patient with monocular open-angle glaucoma

trichiasis

a prostaglandin analog

had


Input: A 53-year-old African American male with HIV was prescribed warfarin 5 mg/day for 12 months after diagnosis of idiopathic deep vein thrombosis and bilateral pulmonary emboli (target INR 2.5 [range 2.0-3.0]).

A 53-year-old African American male with HIV

warfarin 5 mg/day for 12 months

prescribed


Input: After treatment with a beta-sympathomimetic drug (Partusisten) one fetus developed supraventricular tachycardia.

a beta-sympathomimetic drug (Partusisten)

one fetus

supraventricular tachycardia.

developed


Input: Serotonin syndrome developed in a patient taking concurrent linezolid and fluoxetine.

a patient

concurrent linezolid and fluoxetine

Serotonin syndrome

developed


Input: RESULTS: A male and a female patient with spasticity treated with intrathecal baclofen were recognized to have sexual dysfunction side effects from treatment.

A male and a female patient with spasticity

intrathecal baclofen

sexual dysfunction

treated


Input: OBJECTIVE: To describe a patient with ifosfamide-induced nonconvulsive status epilepticus.

patient

ifosfamide

nonconvulsive status epilepticus

induced


Input: Upper gastrointestinal haemorrhage is a serious complication of aspirin and clopidogrel (dual) anti-platelet therapy with a high morbidity and mortality.

Upper gastrointestinal haemorrhage

aspirin and clopidogrel (dual)

complication


Input: Flecainide overdose can rapidly result in profound cardiovascular collapse, and is associated with a relatively high mortality.

Flecainide overdose

profound cardiovascular collapse, and is associated with a relatively high mortality

result


Input: Sulfasalazine-induced lupus erythematosus.

Sulfasalazine

lupus erythematosus

induced


Input: Reye syndrome (RS) is believed to occur infrequently among children receiving long-term aspirin therapy.

Reye syndrome (RS)

long-term aspirin

children

occur


Input: Propecia-associated bilateral cataract.

Propecia

bilateral cataract

associated


Input: After 39 hours on argatroban, the infusion was stopped when minor bleeding was observed with a concurrent activated partial thromboplastin time (aPTT) of 100 seconds.

argatroban

minor bleeding was observed with a concurrent activated partial thromboplastin time (aPTT) of 100 seconds

minor

After


Input: Anaphylactoid reaction to methylprednisolone pulsed therapy for multiple sclerosis.

methylprednisolone pulsed therapy

Anaphylactoid reaction

to


Input: Warfarin-induced skin necrosis and heparin-induced thrombocytopenia following mitral valve replacement for marantic endocarditis.

Warfarin

skin necrosis

induced

heparin

thrombocytopenia

induced


Input: Surprisingly, we found that three patients appeared to develop tardive OGC while taking clozapine.

tardive OGC

clozapine

three patients

appeared

develop


Input: We report a fatal case of toxic epidermal necrolysis (TEN) resulting from a high dose of cytosine arabinoside (ARA-C).

toxic epidermal necrolysis (TEN)

high dose of cytosine arabinoside (ARA-C)

fatal

resulting from


Input: On the fifth day after administration of a high dose of ARA-C (2 g/m2 intravenously every 12 hours), she developed bullous lesions on the hands and soles that disseminated, evolving to necrosis, sepsis, and death on the 22nd day.

high dose of ARA-C

bullous lesions on the hands and soles that disseminated, evolving to necrosis, sepsis, and death

developed


Input: We describe 2 patients with cutaneous lupus erythematosus who developed severe dapsone reaction after low dose therapy, with a fatal outcome in one.

2 patients with cutaneous lupus erythematosus

low dose therapy

severe dapsone reaction

with a fatal outcome in one

fatal

after


Input: A patient with ulcerative colitis developed skin pigmentation and diffuse pulmonary shadowing without respiratory symptomatology, while taking sulfasalazine.

sulfasalazine

A patient with ulcerative colitis

skin pigmentation and diffuse pulmonary shadowing without respiratory symptomatology

developed


Input: This is a case report involving a patient who was treated with topical 5-FU cream and subsequently developed a severe case of angioedema.

a patient

topical 5-FU cream

a severe case of angioedema

developed


Input: Cessation of D-Pen and the start of corticosteroid therapy were followed by recovery from bicytopenia.

Cessation of D-Pen and the start of corticosteroid therapy

recovery from bicytopenia

followed


Input: Prevention of infection by immunization, together with early recognition and prompt antiviral treatment are critical.

immunization, together with early recognition and prompt antiviral treatment

Prevention


Input: A case of normotensive scleroderma renal crisis after high-dose methylprednisolone treatment.

normotensive scleroderma renal crisis

high-dose methylprednisolone treatment

A case

after


Input: OBJECTIVES: A delayed stroke-like leukoencephalopathy has been observed in patients receiving methotrexate (MTX) for childhood leukemia.

delayed stroke-like leukoencephalopathy

methotrexate (MTX)

patients

childhood leukemia

has been observed


Input: Duloxetine-induced hyponatremia in an elderly patient treated with thiazide diuretics.

Duloxetine

hyponatremia

an elderly patient treated with thiazide diuretics

induced


Input: The following is a case report analysis intended to draw attention to the need for better care coordination by describing the observed relationship of olanzapine to metabolic changes manifested as uncontrolled diabetes mellitus and weight gain.

olanzapine

metabolic changes manifested as uncontrolled diabetes mellitus and weight gain

relationship


Input: Arsenic trioxide has recently been introduced as a promising new agent to treat refractory acute promyelocytic leukemia (APL).

Arsenic trioxide

treat


Input: Although the t-AML developed following oral etoposide therapy, the child had previously received high-dose, multiagent chemotherapy, and rearrangement of the MLL gene was not demonstrated.

the child

the t-AML

oral etoposide therapy

high-dose, multiagent chemotherapy

developed


Input: Heat stroke in schizophrenia during clozapine treatment: rapid recognition and management.

Heat stroke

clozapine

during


Input: The same symptoms recurred few days after taking nitrendipine.

nitrendipine

few days after

same symptoms

taking


Input: The authors report two cases of acute dystonic reactions (ADRs) as a side effect of lamivudine.

two cases

acute dystonic reactions (ADRs)

lamivudine

effect


Input: Isoniazid-induced anaphylaxis.

Isoniazid

anaphylaxis

induced


Input: Histopathology of the thyroid in amiodarone-induced hypothyroidism.

amiodarone

hypothyroidism

induced


Input: Deepening of lid sulcus from topical bimatoprost therapy.

Deepening of lid sulcus

bimatoprost

from


Input: Gastro-oesophageal reflux associated with nifedipine.

Gastro-oesophageal reflux

nifedipine

associated


Input: CASE SUMMARY: A 68-year-old woman developed a dry, irritating cough within one month of starting quinapril therapy for the treatment of essential hypertension.

quinapril therapy

A 68-year-old woman

a dry, irritating cough

starting


Input: Sertraline-induced rhabdomyolysis in an elderly patient with dementia and comorbidities.

Sertraline

rhabdomyolysis

an elderly patient with dementia and comorbidities

induced


Input: After the dose of methylprednisolone was reduced from 40 mg to 20 mg i.v. q6h and shifted to other anti-asthma treatment by procaterol metered dose inhaler via spacer, the psychotic reaction disappeared a few hours later.

After the dose of methylprednisolone was reduced from 40 mg to 20 mg i.v. q6h and shifted to other anti-asthma treatment by procaterol metered dose inhaler via spacer

a few hours later

disappeared


Input: Sirolimus works differently from the immunosuppressants currently available, and except for increased lipid levels, the adverse reaction profile of sirolimus does not appear to overlap to any great extent with that associated with cyclosporine or tacrolimus.

increased lipid levels

Sirolimus works differently from the immunosuppressants currently available

for


Input: Patient was on warfarin for a prior deep venous thrombosis.

warfarin

for


Input: Quetiapine-induced myoclonus.

Quetiapine

myoclonus

induced


Input: Dyspnea possibly associated with controlled-release morphine sulfate tablets.

Dyspnea

controlled-release morphine sulfate tablets

possibly

associated


Input: The incidence of ARE suddenly exceeded 10% of the patients treated by melarsoprol during August 1992 and September 1993.

melarsoprol

patients

ARE

by


Input: A patient with disseminated herpes zoster developed a syndrome of inappropriate antidiuretic hormone and profound hyponatremia secondary to the administration of adenine arabinoside.

adenine arabinoside

syndrome of inappropriate antidiuretic hormone and profound hyponatremia

A patient with disseminated herpes zoster

profound

developed


Input: One patient with systemic lupus erythematosus developed erythema multiforme after taking griseofulvin.

One patient with systemic lupus erythematosus

erythema multiforme

griseofulvin

after


Input: We report a rare case of colonic mucosal necrosis following Kalimate (calcium polystryrene sulfonate), an analogue of Kayexalate without sorbitol in a 34-yr-old man.

a 34-yr-old man

colonic mucosal necrosis

Kalimate (calcium polystryrene sulfonate), an analogue of Kayexalate without sorbitol

following


Input: Bilateral anterior uveitis associated with clomiphene citrate.

Bilateral anterior uveitis

clomiphene citrate

associated


Input: Progressive anemia following combination therapy with interferon-alpha and interleukin-2 in a patient with metastatic renal cell carcinoma.

Progressive anemia

a patient with metastatic renal cell carcinoma

combination therapy with interferon-alpha and interleukin-2

following


Input: Metoclopramide-induced parkinsonism.

Metoclopramide

parkinsonism

induced


Input: A 12 year old patient with atrial flutter is presented, in whom intravenous adenosine was followed by acceleration of the heart rate to a potentially dangerous arrhythmia.

12 year old patient with atrial flutter

intravenous adenosine

acceleration of the heart rate to a potentially dangerous arrhythmia

potentially

followed by


Input: Similar to reports in patients receiving gefitinib, those with pathologic findings of UIP on resected lung specimens or known pulmonary fibrosis may be at particular risk for erlotinib pulmonary toxicity.

gefitinib

patients

erlotinib pulmonary toxicity.

receiving


Input: Eleven days after increase of the trimipramine dosage to 100 mg/d, she was hospitalized because of seizures suggesting a secondary generalized grand-mal episode.

Eleven days after increase of the trimipramine dosage to 100 mg/d

she

seizures suggesting a secondary generalized grand-mal episode

hospitalized


Input: AIM: To report a patient with diabetic rubeosis who suffered from acute retinal ischemic change and stroke after intravitreal injection of bevacizumab.

patient with diabetic rubeosis

acute retinal ischemic change and stroke

intravitreal injection of bevacizumab

acute

suffered


Input: Stevens-Johnson syndrome caused by the antiretroviral drug nevirapine.

Stevens-Johnson syndrome

antiretroviral drug nevirapine

caused by


Input: From these data, acute generalized dystonia with brainstem and thalamic lesions may occur in WD patients after an initial d-penicillamine therapy.

an initial d-penicillamine therapy

WD patients

acute generalized dystonia with brainstem and thalamic lesions

may occur

acute

after


Input: Although this combination agent has been associated with a hypersensitivity syndrome involving cutaneous skin eruptions, pediatric cases of TMP-SMX-induced hepatotoxicity are rare.

TMP-SMX

hepatotoxicity

pediatric cases

induced


Input: Drug resistant tuberculosis requires more complex and longer treatment with alternative substances.

complex and longer treatment with alternative substances

requires


Input: Intracranial haemorrhage from a meningioma in a patient receiving aspirin prophylaxis: a case report.

Intracranial haemorrhage from a meningioma

a patient

aspirin

in


Input: The objective of this report is to describe a case of fixed drug eruption that occurred during omeprazole treatment.

fixed drug eruption

during omeprazole treatment

occurred


Input: Case 2: A 43-year-old male alcoholic remained completely abstinent with cyanamide treatment for 5 years and complained of general fatigue.

A 43-year-old male alcoholic

completely abstinent with cyanamide treatment for 5 years

general fatigue

complained


Input: Delayed hypersensitivity to flurbiprofen.

Delayed hypersensitivity

flurbiprofen

to


Input: Propafenone-induced ataxia: report of three cases.

ataxia

Propafenone

three cases

induced


Input: Delavirdine and efavirenz (but not nevirapine) also were strong inhibitors of CYP3A, consistent with clinical hazards of initial cotreatment with either of these drugs and substrates of CYP3A.

Delavirdine and efavirenz (but not nevirapine)

clinical hazards

consistent with


Input: This is the first report of UFT-induced scleroderma-like reaction.

UFT

scleroderma-like reaction

induced


Input: Can roxithromycin and betamethasone induce acute pancreatitis? A case report.

roxithromycin and betamethasone

acute pancreatitis

induce


Input: Up to four percent of patients treated with imatinib may develop hepatotoxicity, which usually resolves with discontinuation of the drug.

Up to four percent of patients

imatinib

hepatotoxicity

may

develop


Input: Schneiderian first-rank symptoms associated with fluvoxamine treatment: a case report.

fluvoxamine

Schneiderian first-rank symptoms

associated


Input: Peripheral and optic neuropathy was usually seen after several months of linezolid therapy (median 5 mo), lactic acidosis after several weeks (median 6 wks), and serotonin syndrome after several days (median 4 days).

Peripheral and optic neuropathy

lactic acidosis after several weeks (median 6 wks), and serotonin syndrome after several days (median 4 days)

several months of linezolid therapy (median 5 mo)

after


Input: Muzolimine-induced severe neuromyeloencephalopathy: report of seven cases.

Muzolimine

neuromyeloencephalopathy

severe

induced


Input: We conclude peripheral neuropathy with 5-FU is rare.

peripheral neuropathy

rare

with


Input: Additionally, danazol produces hepatocellular damage in approximately 10% of women.

danazol

hepatocellular damage

10% of women

produces


Input: CONCLUSIONS: We report a typical symptoms of Charles-Bonnet syndrome (CBS) in patients with severe AMD after intravitreal Avastin-injections.

typical symptoms of Charles-Bonnet syndrome (CBS)

patients with severe AMD

intravitreal Avastin-injections

after


Input: Proconvulsive tendency of imipenem/cilastatin is one of its well-known side effects.

imipenem/cilastatin

Proconvulsive tendency

side effects


Input: A 49-year-old man with Crohn's disease treated with prednisone and mesalamine (5-ASA) developed worsening respiratory distress and fever.

49-year-old man with Crohn's disease

worsening respiratory distress and fever.

prednisone and mesalamine (5-ASA)

worsening

developed


Input: OBJECTIVE: This case report outlines a significant type of morbidity due to continued use of gabapentin during an episode of acute renal failure.

gabapentin

a significant type of morbidity

This case

use


Input: Acute delirium resulting from levofloxacin therapy is an exceedingly rare complication that has been thought to occur more commonly in elderly patients.

elderly patients

Acute delirium

levofloxacin

exceedingly rare

resulting


Input: Selective estrogen receptor modulator raloxifene-associated aggravation of nonalcoholic steatohepatitis.

raloxifene

aggravation of nonalcoholic steatohepatitis

associated


Input: The day after methotrexate administration, the patient complained of severe back pain and urinary retention.

The day after methotrexate administration

severe back pain and urinary retention

complained


Input: Pulmonary toxicity secondary to procarbazine.

Pulmonary toxicity

procarbazine

secondary


Input: In keeping with findings in the literature, the aortic wall in this case was damaged by secondary changes following irradiation and Bleomycin treatment.

aortic wall in this case was damaged

irradiation and Bleomycin treatment.

following


Input: It has been suggested that PPE caused by cytarabine does not recur with subsequent cytarabine re-challenge.

PPE

cytarabine

not

caused


Input: CONCLUSIONS: The value of multihormonal therapy in breast carcinoma is not established, and the addition of progestogens to tamoxifen may not reduce of developing endometrial lesions, including carcinoma.

endometrial lesions

carcinoma

addition of progestogens to tamoxifen

may

may not reduce


Input: Inappropriate antidiuretic hormone following adenine arabinoside administration.

Inappropriate antidiuretic hormone

adenine arabinoside

following


Input: Ampicillin-associated seizures.

Ampicillin

seizures

associated


Input: We describe a case of fibrosing alveolitis, diagnosed by lung biopsy, in a patient receiving amiodarone which responded to corticosteroid therapy.

fibrosing alveolitis

a patient

amiodarone which responded to corticosteroid therapy

receiving


Input: Furosemide-associated fever.

Furosemide

fever

associated


Input: Thymic enlargement in a patient with juvenile idiopathic arthritis during etanercept therapy.

Thymic enlargement

a patient with juvenile idiopathic arthritis

etanercept

during


Input: Fatal methylene blue associated serotonin toxicity.

methylene blue

serotonin toxicity

Fatal

associated


Input: Mannitol-induced ARF responds promptly to hemodialysis with rapid resolution of anuria and recovery of renal failure.

ARF

anuria

renal failure

Mannitol

induced


Input: We report a rare case of recurrent (stuttering) priapism in a patient with protein C deficiency while maintained on Warfarin therapy.

recurrent (stuttering) priapism

a patient with protein C deficiency

maintained on Warfarin therapy

while


Input: Angioedema and maculopapular eruptions associated with carbamazepine administration.

Angioedema and maculopapular eruptions

carbamazepine administration.

associated


Input: Mental nerve neuropathy as a result of hepatitis B vaccination.

hepatitis B vaccination

Mental nerve neuropathy

result


Input: We describe a premenopausal woman who, while having tamoxifen due to a diagnosis of in situ ductal carcinoma, developed endometriosis requiring surgery.

a premenopausal woman

tamoxifen

endometriosis

requiring surgery

developed


Input: Disseminated cellulitic cryptococcosis in the setting of prednisone monotherapy for pemphigus vulgaris.

Disseminated cellulitic cryptococcosis

prednisone monotherapy

in the setting of


Input: We describe a 63 year old woman with a suppurative mediastinitis, treated with continuous PI irrigation who developed an acute oliguric renal failure.

a 63 year old woman with a suppurative mediastinitis

continuous PI irrigation

acute oliguric renal failure

developed


Input: A young woman with epilepsy had tonic-clonic seizures during antineoplastic therapy with adriamycin and cisplatin.

antineoplastic therapy with adriamycin and cisplatin.

A young woman with epilepsy

tonic-clonic seizures

had


Input: CONCLUSIONS: This patient's rhabdomyolysis was probably induced by sertraline therapy.

This patient

rhabdomyolysis

sertraline

probably

induced


Input: Nephrotic syndrome in a multiple sclerosis patient treated with interferon beta 1a.

Nephrotic syndrome

a multiple sclerosis patient

interferon beta 1a

treated


Input: In our patient, DIAN possibly was related to cefuroxime, but the patient did not experience associated allergic symptoms.

cefuroxime

DIAN

our patient

related to


Input: We describe the case of a nonatopic 17-year-old girl with bronchial asthma and aspirin intolerance who developed a dramatic anaphylactic reaction to oral prednisone.

a nonatopic 17-year-old girl with bronchial asthma and aspirin intolerance

a dramatic anaphylactic reaction

oral prednisone

developed


Input: CASE SUMMARY: A 10-year-old white girl with bilateral optic glioma developed a hypersensitivity reaction to carboplatin after nine courses.

A 10-year-old white girl with bilateral optic glioma

hypersensitivity reaction

carboplatin after nine courses

developed


Input: Liver function should be carefully monitored when rifampicin and lopinavir/ritonavir are combined in patients.

patients

Liver function should be carefully monitored

rifampicin and lopinavir/ritonavir are combined

monitored

when


Input: We report three patients, all of whom had preexisting diabetic dyslipidemia, who showed a profound reduction in plasma HDL cholesterol and apolipoprotein AI levels soon after the initiation of rosiglitazone therapy.

three patients

profound reduction in plasma HDL cholesterol and apolipoprotein AI levels

rosiglitazone therapy

initiation


Input: This finding suggests that fluvoxamine can precipitate Schneiderian first-rank symptoms in some susceptible patients.

fluvoxamine

Schneiderian first-rank symptoms

some susceptible patients

suggests

precipitate


Input: Warfarin-associated thoracic aortic dissection in an elderly woman.

Warfarin

thoracic aortic dissection

an elderly woman

associated


Input: This is the first report of an adverse effect of fetal renal circulation by maternal ingestion of nimesulide.

first report of an adverse effect of fetal renal circulation

maternal ingestion of nimesulide

nimesulide

fetal renal circulation

adverse effect


Input: Diarrhea-associated over-anticoagulation in a patient taking warfarin: therapeutic role of cholestyramine.

warfarin

Diarrhea-associated over-anticoagulation

patient

over-anticoagulation


Input: A 72-year-old white man suddenly developed combative behavior, refused to leave his room, stopped eating, and began falling to the floor 6 weeks after being given ticlopidine.

A 72-year-old white man

combative behavior, refused to leave his room, stopped eating, and began falling to the floor

6 weeks after being given ticlopidine

developed


Input: The case history confirms that gold treatment, even in the same patient, can give rise to a wide range of skin disturbances, which in many cases do not break out until long after the drug has been withdrawn.

gold

wide range of skin disturbances, which in many cases do not break out until long after the drug has been withdrawn

in the same patient,

give rise


Input: Lithium neurotoxicity should be considered in Creutzfeldt-Jakob disease differential diagnosis, serial electroencephalograms being the most valuable.

Lithium

Lithium neurotoxicity

should

considered


Input: The authors describe a case of neuroleptic malignant syndrome that occurred in a patient on amitriptyline and lithium carbonate.

neuroleptic malignant syndrome

amitriptyline and lithium carbonate

a patient

occurred


Input: The findings were judged to be consistent with soft-tissue injury associated with intravenous administration of phenytoin, also termed purple glove syndrome.

intravenous administration of phenytoin

soft-tissue injury

associated


Input: However, as illustrated by these and other cases reported to date, the onset of troglitazone-induced liver injury is insidious and temporally variable.

troglitazone

liver injury is insidious and temporally variable

induced


Input: Soon after its introduction in 1952, chlorpromazine was noted to induce symptoms resembling Parkinson's disease.

chlorpromazine

symptoms resembling Parkinson's disease

induce


Input: Erythromycin is a macrolide antibiotic that may increase the risk of lovastatin-induced rhabdomyolysis.

Erythromycin

ncrease the risk of lovastatin-induced rhabdomyolysis

may

induced


Input: A 23-year-old white male patient was originally admitted to receive intravenous chemotherapy for acute myelogenous leukemia.

intravenous chemotherapy

A 23-year-old white male patient

receive


Input: We present two children with acute lymphocytic leukemia who developed leukoencephalopathy following administration of a combination of intravenous ara = C and methotrexate during the consolidation phase of chemotherapy.

two children with acute lymphocytic leukemia

leukoencephalopathy

administration of a combination of intravenous ara = C and methotrexate during the consolidation phase of chemotherapy

developed


Input: Lethal anuria complicating high dose ifosfamide chemotherapy in a breast cancer patient with an impaired renal function.

a breast cancer patient with an impaired renal function

high dose ifosfamide chemotherapy

anuria

Lethal

complicating


Input: CONCLUSIONS: Low dosages of quinacrine used for malaria prophylaxis can be associated with a delayed, severe maculopathy indistinguishable from chloroquine maculopathy in certain patients.

a delayed, severe maculopathy

Low dosages of quinacrine used for malaria prophylaxis

severe

associated

Low dosages of quinacrine used for malaria prophylaxis

chloroquine maculopathy

certain patients.

associated


Input: When pilsicainide is prescribed in patients with coronary artery disease or renal dysfunction, close attention must be paid to avoid life-threatening arrhythmias due to high plasma concentrations of the drug.

pilsicainide

life-threatening arrhythmias

patients with coronary artery disease or renal dysfunction,

due


Input: We describe a case of severe aplastic anemia (AA) that was probably induced by lenalidomide.

lenalidomide

severe aplastic anemia (AA)

a case

probably

induced


Input: We present a case report of a patient with typhoid fever who experienced a hypersensitivity reaction subsequent to the infusion of chloramphenicol sodium succinate.

a patient with typhoid fever

hypersensitivity reaction

the infusion of chloramphenicol sodium succinate

subsequent to


Input: This confirmed the history of captopril-related asthma.

captopril

asthma

related


Input: Four cases of adverse experiences with clonidine are described.

Four cases

clonidine

adverse experiences

with


Input: OBJECTIVE: To report a case of reversible nonthrombocytopenic palpable purpura associated with metoclopramide.

reversible nonthrombocytopenic palpable purpura

metoclopramide

associated


Input: Three patients received respectively 190 mg, 175 mg, and 196 mg of methotrexate and developed bilateral pulmonary infiltrates without evidence of peripheral blood eosinophilia.

Three patients

received respectively 190 mg, 175 mg, and 196 mg of methotrexate

bilateral pulmonary infiltrates without evidence of peripheral blood eosinophilia

developed


Input: Clinicians should be aware of the possibility that vinorelbine may cause SIADH and possibly hypokalemia.

vinorelbine

SIADH and possibly hypokalemia

may

cause


Input: We report a case of a 34-year-old man on carbamazepine for complex partial seizures who developed acute liver and renal failure on less than 2.5 grams a day of acetaminophen.

carbamazepine

less than 2.5 grams a day of acetaminophen

acute liver and renal failure

a 34-year-old man

on


Input: Fever and maculopapular rashes appeared at 10 days after phenytoin initiation, and then the drug was discontinued.

phenytoin

Fever and maculopapular rashes

appeared


Input: We report AZA-induced drug eruption that developed in two cases of systemic scleroderma with polymyositis.

AZA

drug eruption

two cases of systemic scleroderma with polymyositis

induced


Input: Safety aspects of a coumarin-troxerutin combination regarding liver function in a double-blind placebo-controlled study.

coumarin-troxerutin combination

liver function

Safety aspects


Input: Vogt-Koyanagi-Harada disease occurring during interferon alpha therapy for chronic hepatitis C.

Vogt-Koyanagi-Harada disease

interferon alpha

occurring


Input: Glucose and insulin exert additive ocular and renal vasodilator effects on healthy humans.

healthy humans

additive ocular and renal vasodilator effects

Glucose and insulin

exert


Input: Two patients with osteomyelitis who developed reversible cholestatic jaundice during treatment with oxacillin derivatives are described.

Two patients with osteomyelitis

reversible cholestatic jaundice

oxacillin

developed


Input: DATA SYNTHESIS: A 49-year-old man developed symptoms of severe psychosis concomitant with ciprofloxacin (250 mg bid) treatment.

A 49-year-old man

ciprofloxacin

psychosis

severe

developed


Input: Beneficial effect of low-dose mianserin on fluvoxamine-induced akathisia in an obsessive-compulsive patient.

fluvoxamine

akathisia

obsessive-compulsive patient

induced

obsessive-compulsive patient

low-dose mianserin

Beneficial


Input: Potential causes of methamphetamine-related keratitis can be divided into four categories resulting from (a) direct pharmacologic and physical effects of methamphetamine; (b) the toxic effects of diluting or "cutting" agents such as lidocaine and quinine; (c) effects related to the route of drug administration (intravenous, inhalation, smoking); and (d) manufacture-related effects of exposure to unintentional caustic contaminants in the final product.

methamphetamine

keratitis

related


Input: Pulmonary oedema after hexoprenaline administration in preterm labour.

Pulmonary oedema

hexoprenaline

after


Input: Venlafaxine-associated seizures at therapeutic doses have not been reported in the literature.

Venlafaxine

seizures

not

associated


Input: Methotrexate-induced pneumonitis in patients with rheumatoid arthritis and psoriatic arthritis: report of five cases and review of the literature.

Methotrexate

pneumonitis

patients with rheumatoid arthritis and psoriatic arthritis

induced


Input: She was receiving phenytoin sodium 300 mg/day; carbamazepine 200 mg four times daily had been discontinued four days before admission because of leukopenia.

leukopenia

carbamazepine 200 mg four times daily

because


Input: Thoracoscopic biopsy to confirm metastasis revealed instead fibrotic lesions apparently attributable to bleomycin or cyclophosphamide.

fibrotic lesions

bleomycin or cyclophosphamide

apparently

attributable


Input: We present a case of hemolytic-uremic syndrome that developed during the 4th cycle of combination chemotherapy with oxaliplatin, 5-fluorouracil and leucovorin.

hemolytic-uremic syndrome

during the 4th cycle of combination chemotherapy with oxaliplatin, 5-fluorouracil and leucovorin

developed


Input: We report the case of a lung cancer patient with bronquiloalveolar carcinoma (BAC) presenting with BOOP after chemotherapy with docetaxel and gemcitabine producing severe respiratory insufficiency, and simulating a progression of the tumor.

lung cancer patient with bronquiloalveolar carcinoma (BAC)

producing severe respiratory insufficiency, and simulating a progression of the tumor

BOOP

chemotherapy with docetaxel and gemcitabine

after


Input: Relapse in the external auditory canal of acute promyelocytic leukemia after treatment with all-trans retinoic acid.

Relapse in the external auditory canal of acute promyelocytic leukemia

treatment with all-trans retinoic acid

after


Input: Acute neutrophilic dermatosis induced by all-trans-retinoic acid treatment for acute promyelocytic leukemia.

Acute neutrophilic dermatosis

all-trans-retinoic acid

induced by


Input: Fluphenazine-induced neuroleptic malignant syndrome in a schizophrenic patient.

Fluphenazine

neuroleptic malignant syndrome

a schizophrenic patient

induced


Input: Biopsy-proven acute interstitial nephritis associated with the tyrosine kinase inhibitor sunitinib: a class effect?

acute interstitial nephritis

tyrosine kinase inhibitor sunitinib

associated


Input: We describe two women who developed HUS after MMC therapy and presented massive pulmonary bleeding.

two women

HUS

massive pulmonary bleeding

MMC

massive

after


Input: Alternating sinus rhythm and intermittent sinoatrial (S-A) block was observed in a 57-year-old woman, under treatment for angina with 80 mg propranolol daily.

80 mg propranolol daily.

a 57-year-old woman

Alternating sinus rhythm and intermittent sinoatrial (S-A) block

treatment


Input: These case reports provide evidence that 5-aminosalicylic acid may induce acute pancreatitis after long term treatment.

5-aminosalicylic acid

acute pancreatitis

induce


Input: During that time, he had also been taking amphetamine-dextroamphetamine (Adderall) on work days for his ADHD.

amphetamine-dextroamphetamine (Adderall)

he

taking


Input: Therefore, we diagnosed her eruption as contact dermatitis due to sodium bisulfite.

sodium bisulfite

r eruption as contact dermatitis

diagnosed


Input: Macular infarction after endophthalmitis treated with vitrectomy and intravitreal gentamicin.

Macular infarction

endophthalmitis treated with vitrectomy and intravitreal gentamicin

after


Input: Since tamoxifen therapy can induce endometrial disorders, surveillance schemes of women taking tamoxifen have been recommended.

tamoxifen therapy

endometrial disorders

women

induce


Input: Warfarin-associated bleeding complication saved life.

Warfarin

bleeding complication saved life

associated


Input: METHODS/RESULTS: This paper presents a new case of rifabutin uveitis and a review of the various published reports to date.

rifabutin

uveitis

new case

presents


Input: Acute abdomen due to endometriosis in a premenopausal woman taking tamoxifen.

Acute abdomen due to endometriosis

tamoxifen

taking


Input: DISCUSSION: Methotrexate-induced papular eruption is rarely reported shortly after beginning methotrexate therapy in patients with acute exacerbation of collagen vascular diseases.

Methotrexate

papular eruption

patients with acute exacerbation of collagen vascular diseases

induced


Input: We describe 3 patients on concomitant amiodarone and warfarin who developed amiodarone-induced thyrotoxicosis heralded by a significant decrease in warfarin requirements.

amiodarone-induced thyrotoxicosis

3 patients

concomitant amiodarone and warfarin

developed

amiodarone

thyrotoxicosis

induced


Input: The aim of this post-hoc analysis of data from a Phase III clinical trial (VISTA; NCT00298831) was to investigate the impact of antibiotics on recovery from rocuronium-induced NMB after administration of sugammadex for reversal, and compared the neuromuscular recovery in patients who received antibiotics preoperatively with those who did not.

rocuronium

NMB

induced

antibiotics

recovery


Input: All patients had taken phenytoin for variable time periods (range 16-80 days; mean: 40) and were on the medication when the skin lesions first appeared.

phenytoin for variable time periods (range 16-80 days; mean: 40)

All patients

skin lesions

appeared


Input: One should therefore be aware of possible extrapyramidal side effects with olanzapine that are reduced compared to classical neuroleptic drugs but not completely eliminated.

extrapyramidal side effects

olanzapine

possible

with


Input: A patient who had been treated with large doses of thyroid hormone for several years developed features of secondary hypothyroidism after thyroid hormone withdrawal.

A patient

thyroid hormone withdrawal

secondary hypothyroidism

developed


Input: This article discusses the possibility that simultaneous use of valproic acid, lamotrigine, and phenytoin could give this combination of toxicities and that concurrent viral infection may increase this risk.

valproic acid, lamotrigine, and phenytoin

toxicities

concurrent viral infection

possibility

give


Input: A second patient with a similar glucose tolerance test result showed postprandial hyperglycemia when treated similarly with betamethasone valerate cream 0.1%.

postprandial hyperglycemia

betamethasone valerate cream 0.1%

showed


Input: Phenytoin-induced hypersensitivity reactions.

Phenytoin

hypersensitivity reactions.

induced


Input: A 54-year-old man developed TEN 4 weeks after beginning lamotrigine for complex partial seizures related to a glioblastoma multiforme brain tumor.

A 54-year-old man

complex partial seizures related to a glioblastoma multiforme brain tumor

TEN

4 weeks after beginning lamotrigine

developed


Input: The occurrence of acute hepatitis is best known for ketoconazole.

ketoconazole

acute hepatitis

for


Input: Optic neuropathy developed in a patient with rheumatoid arthritis who had been receiving D-penicillamine for about 1 year.

Optic neuropathy

a patient with rheumatoid arthritis

D-penicillamine for about 1 year

developed


Input: Stupor and fast activity on electroencephalography in a child treated with valproate.

a child

valproate

Stupor

fast activity on electroencephalography

with