Input: Here we present the case of a woman who received high doses of methylprednisolone (1 g iv daily) for active Graves' ophthalmopathy, and developed severe hypertension followed by myocardial infarction on the fifth day of treatment.

a woman

high doses of methylprednisolone (1 g iv daily)

severe hypertension followed by myocardial infarction on the fifth day of treatment.

severe

received


Input: Severe cardiomyopathy following treatment with the tumour necrosis factor-alpha inhibitor adalimumab for Crohn's disease.

cardiomyopathy

treatment with the tumour necrosis factor-alpha inhibitor adalimumab

Severe

following


Input: There are now reports of liver failure following treatment of childhood cancers with AMD.

childhood cancers

liver failure

AMD

following


Input: Imatinib mesylate-related fatal acute hepatic failure in a patient with chronic myeloid leukaemia and chronic hepatitis B infection.

fatal acute hepatic failure

Imatinib mesylate

a patient with chronic myeloid leukaemia and chronic hepatitis B infection

fatal

related


Input: This phase 3, randomized, double-blind 1-yr study assessed the effects of combined RLX and ALN in 331 postmenopausal women with osteoporosis (femoral neck BMD T-score, less than -2).

combined RLX and ALN

331 postmenopausal women with osteoporosis (femoral neck BMD T-score, less than -2)

assessed

effects


Input: Phenytoin toxicity due to concomitant antituberculosis therapy.

Phenytoin toxicity

concomitant antituberculosis therapy.

due


Input: Hemodialysis should be performed for rapid reversal of mannitol-induced ARF.

mannitol

ARF

induced

Hemodialysis

performed


Input: Amiodarone is well recognized as an anti-arrhythmic drug containing a high dose of iodine with considerable potential to cause thyroid dysfunction.

Amiodarone

potential to cause thyroid dysfunction

recognized


Input: Pulmonary infiltrates and skin pigmentation associated with sulfasalazine.

sulfasalazine

Pulmonary infiltrates and skin pigmentation

associated


Input: Lithium treatment was terminated in 1975 because of lithium intoxication with a diabetes insipidus-like syndrome.

Lithium treatment

lithium intoxication with a diabetes insipidus-like syndrome

because


Input: The authors report a longitudinal case study of a woman with a history of bipolar affective disorder in which L-dopa shortened the manic-depressive cycle length when administered in a double-blind trial.

a woman with a history of bipolar affective disorder

L-dopa

shortened the manic-depressive cycle length

shortened


Input: Isoniazid causing breast tissue enlargement has been very rarely reported.

breast tissue enlargement

Isoniazid

causing


Input: The induction of hypoglycaemia with PAS in this patient suggests a potential role for PAS in the treatment of diabetes mellitus.

hypoglycaemia

PAS

this patient

induction


Input: Although both patients recovered from the colitis after the administration of vancomycin, the first case demonstrated a relapse of the colitis after receiving a subsequent course of the same chemotherapy with cisplatin.

vancomycin

both patients

recovered

a relapse of the colitis

a subsequent course of the same chemotherapy with cisplatin

receiving


Input: Acute dystonia during pegylated interferon alpha therapy in a case with chronic hepatitis B infection.

Acute dystonia

pegylated interferon alpha

therapy


Input: I saw two patients with kala-azar resistant to sodium stibogluconate who developed cardiac arrest after amphotericin infusion (in spite of tolerating a test dose).

two patients with kala-azar resistant to sodium stibogluconate

cardiac arrest

amphotericin infusion

developed


Input: CONCLUSIONS: Anastrozole may be the causative factor in patients with sclerosing glomerulonephritis.

Anastrozole

patients

sclerosing glomerulonephritis

may

causative


Input: We describe two cases of acute pancreatitis that occurred after long term mesalamine therapy for ulcerative colitis.

acute pancreatitis

mesalamine

two cases

occurred


Input: Amphotericin B (AmB) is effective, but its use is limited by toxicity: renal impairment, anaemia, fever, malaise, and hypokalaemia are common.

toxicity: renal impairment, anaemia, fever, malaise, and hypokalaemia

Amphotericin B (AmB)

common

by


Input: We believe that a drug interaction between terfenadine and ketoconazole resulted in the elevated terfenadine levels in plasma and in the cardiotoxicity previously seen only in cases of terfenadine overdose.

a drug interaction between terfenadine and ketoconazole

the elevated terfenadine levels in plasma and in the cardiotoxicity

resulted


Input: A case of halothane induced hepatitis is reported in a middle aged woman who underwent gastric surgery for morbid obesity.

a middle aged woman

halothane

gastric surgery for morbid obesity

hepatitis

induced


Input: Carbonic anhydrase inhibitors used in the treatment of glaucoma, seizure disorders, and hypertension are rarely associated with blood dyscrasias.

Carbonic anhydrase inhibitors

blood dyscrasias

rarely associated


Input: Administration of intrathecal Ara-C in the same dose over longer intervals within 3-5 days between consecutive doses resulted in mild, transient neurological symptoms (paresthesias) in only one of 30 patients so treated.

Administration of intrathecal Ara-C in the same dose over longer intervals within 3-5 days between consecutive doses

neurological symptoms

one of 30 patients

mild

resulted


Input: Anaphylaxis from isoniazid is a possible side effect to this commonly prescribed antibiotic.

isoniazid

commonly prescribed antibiotic

Anaphylaxis

possible

is


Input: Among 12 thyrotoxic patients, a patient with arrhythmogenic right ventricular dysplasia, who had been taking amiodarone for 4 years, developed thyrotoxicosis with subacute onset, accompanied by transiently positive thyrotropin (TSH) receptor antibody (TRAb), or thyrotropin-binding inhibiting immunoglobulin (TBII).

a patient with arrhythmogenic right ventricular dysplasia

amiodarone for 4 years

thyrotoxicosis with subacute onset, accompanied by transiently positive thyrotropin (TSH) receptor antibody (TRAb), or thyrotropin-binding inhibiting immunoglobulin (TBII)

developed


Input: Methotrexate-induced papular eruption following treatment of psoriasis.

Methotrexate

papular eruption

induced


Input: Sexual dysfunction associated with intrathecal baclofen use: a report of two cases.

Sexual dysfunction

intrathecal baclofen

two cases

associated


Input: Patients treated with L-asparaginase may present with hemorrhagic and thrombotic cerebrovascular events.

Patients

L-asparaginase

hemorrhagic and thrombotic cerebrovascular events

may

present


Input: Since imiquimod induces large amounts of type I interferon production from TLR7-expressing plasmacytoid dendritic cell precursors (PDCs), the natural interferon-producing cells of the peripheral blood, we asked whether PDCs are present in psoriatic skin.

imiquimod

large amounts of type I interferon production

induces


Input: Ptosis occurring 24 h after chloroquine therapy, with full recovery 48 h after cessation of chloroquine, has not been described previously.

Ptosis

full recovery 48 h after cessation of chloroquine

chloroquine therapy

full recovery

occurring


Input: Hypersensitivity pneumonitis-like syndrome associated with the use of lenalidomide.

Hypersensitivity pneumonitis-like syndrome

lenalidomide

associated


Input: Incidence of seizures in pediatric cancer patients treated with imipenem/cilastatin.

seizures

pediatric cancer patients

imipenem/cilastatin

treated


Input: One of these was clofazimine, an aniline aposafranine derivative known to produce a ceroid-like pigment in the tissues of patients treated with this drug or lepromatous leprosy.

clofazimine

a ceroid-like pigment

patients treated with this drug or lepromatous leprosy

produce


Input: Deposits of plasma proteins in the skin during treatment with carbamazepine and diphenylhydantoin.

carbamazepine and diphenylhydantoin

Deposits of plasma proteins in the skin

treatment


Input: 2-Chloro-deoxyadenosine induces durable complete remission in Castleman's disease but may accelerate its transformation to non-Hodgkin's lymphoma.

non-Hodgkin's lymphoma

may

accelerate


Input: Hypersensitivity to aspirin can be manifested as acute asthma, urticaria and/or angioedema, or a systemic anaphylactoid reaction.

aspirin

acute asthma

urticaria

angioedema

systemic anaphylactoid reaction

Hypersensitivity

can

manifested


Input: An exaggerated hypertensive response to glycopyrrolate therapy for bradycardia associated with high-dose dexmedetomidine.

bradycardia

high-dose dexmedetomidine

associated

glycopyrrolate

exaggerated hypertensive

response


Input: Only one patient, the youngest, did well on risperidone therapy.

the youngest

risperidone

did well


Input: Two elderly women suffered an acute deterioration of renal function after treatment with cefoxitin sodium.

Two elderly women

acute deterioration of renal function

treatment with cefoxitin sodium

after


Input: Physicians should suspect pulmonary toxicity in patients with respiratory distress after gemcitabine chemotherapy, mainly in elderly patients.

pulmonary toxicity

patients with respiratory distress

mainly in elderly patients

gemcitabine chemotherapy

suspect

after


Input: Delay of corneal wound healing in patients treated with colchicine.

patients

colchicine

Delay of corneal wound healing

treated


Input: Amiodarone-induced thyrotoxicosis associated with thyrotropin receptor antibody.

Amiodarone

thyrotoxicosis

induced


Input: CONCLUSION: All doctors need to be aware of the need to review the indications for gabapentin use during periods of acute illness, especially with regard to renal impairment.

gabapentin

renal impairment

regard


Input: EA signs were observed in all 7 patients in association with propofol TIVA but did not recur in any of 123 subsequent anesthetics sessions during which low-dose ketamine was added to propofol.

all 7 patients

propofol TIVA

low-dose ketamine was added to propofol

EA signs

observed


Input: The cause of death was multiple drug intoxication following acute use of sertraline, the manner of death was suicide, and the mechanism of death is an unexplained drug interaction and/or toxicity.

multiple drug intoxication

sertraline

unexplained

following


Input: On the next day, after a total dose of only 600 mg of danazol, gingival bleeding and purpura occurred.

gingival bleeding and purpura

On the next day, after a total dose of only 600 mg of danazol

occurred


Input: SLE receded after withdrawal of carbamazepine and treatment with anti-inflammatory drugs.

withdrawal of carbamazepine and treatment with anti-inflammatory drugs

after


Input: a 67-year-old man with bipolar disorder developed a Creutzfeldt-Jakob like syndrome during lithium carbonate treatment.

a 67-year-old man with bipolar disorder

Creutzfeldt-Jakob like syndrome

lithium carbonate

during


Input: A 42 year old man, treated for testicular carcinoma with combination chemotherapy that included bleomycin, developed life threatening interstitial pneumonitis.

42 year old man

combination chemotherapy that included bleomycin,

interstitial pneumonitis

life threatening

developed


Input: Disseminated eruptive giant mollusca contagiosa in an adult psoriasis patient during efalizumab therapy.

efalizumab therapy

an adult psoriasis patient

Disseminated eruptive giant mollusca contagiosa

during


Input: Significant clinical improvement of the porphyria followed withdrawal of the diphenylhydantoin.

withdrawal of the diphenylhydantoin

improvement


Input: Temozolomide was restarted 2 months later; the patient again developed a fever.

fever

the patient

Temozolomide

developed


Input: The patient's previous rash and the temporal relation of this event and the ingestion of phenolphthalein, as well as the similarity of this case to other reports, point to phenolphthalein as the cause of TEN in this patient.

ingestion of phenolphthalein

TEN

The patient's previous rash

cause


Input: Ciprofloxacin greatly elevates plasma concentrations of tizanidine and dangerously potentiates its hypotensive and sedative effects, mainly by inhibiting its CYP1A2-mediated metabolism, at least when administered 1 hour before tizanidine.

Ciprofloxacin

plasma concentrations of tizanidine and dangerously potentiates its hypotensive and sedative effects

elevates


Input: RESULTS: The patient, a 27-year-old married Japanese woman with borderline personality disorder, developed an increased libido with the administration of fluvoxamine.

The patient, a 27-year-old married Japanese woman with borderline personality disorder

increased libido

administration of fluvoxamine

developed


Input: Acute renal failure with severe tubulointerstitial changes in a patient with minimal change nephrotic syndrome treated with enalapril.

enalapril

a patient with minimal change nephrotic syndrome

Acute renal failure with severe tubulointerstitial changes

severe

in


Input: PURPOSE: A case of carbamazepine-induced hyperammonemia is presented.

A case

carbamazepine

hyperammonemia

induced


Input: The cough continued for the duration of therapy with quinapril.

cough

quinapril

continued


Input: OBJECTIVE: To report a case of Carbamazepine toxicity following the administration of Oxybutynin and Dantrolene.

Carbamazepine

Oxybutynin and Dantrolene

Carbamazepine toxicity

following


Input: Danazol induced thrombocytopenia.

Danazol

thrombocytopenia

induced


Input: Four elderly LTCF residents treated with serotonergic antidepressants including selective serotonin reuptake inhibitor (SSRI) or mirtazapine and opioids.

Four elderly LTCF residents

serotonergic antidepressants including selective serotonin reuptake inhibitor (SSRI) or mirtazapine and opioids

treated


Input: Detection of antineutrophil cytoplasmic antibody in a patient with L-tryptophan induced eosinophilia-myalgia syndrome.

patient

eosinophilia-myalgia syndrome

L-tryptophan

induced


Input: His impaired memory was found to be due to the atenolol he was on and he made a complete recovery on withdrawing the beta-blocker.

impaired memory

he

atenolol

due


Input: Tiagabine overdose causes an unusual array of neurological symptoms, many similar to reported adverse effects during therapeutic use.

Tiagabine overdose

an unusual array of neurological symptoms

causes


Input: This paper reports on a 6.9-year-old autistic male who developed repeated episodes of acute dystonic reactions associated with pimozide administration at the doses of 0.096 mg/kg/day and 0.032 mg/kg/day and 32 hours following pimozide withdrawal, as well as during subsequent thioridazine administration.

6.9-year-old autistic male

repeated episodes of acute dystonic reactions

pimozide administration at the doses of 0.096 mg/kg/day and 0.032 mg/kg/day and 32 hours following pimozide withdrawal, as well as during subsequent thioridazine administration

associated


Input: Cephalexin rash in infectious mononucleosis.

Cephalexin rash

Cephalexin

in


Input: He developed recurrent skin rash, fever, hypereosinophilia, and acute renal failure after rechallenge with chlorambucil.

recurrent skin rash, fever, hypereosinophilia, and acute renal failure

rechallenge with chlorambucil

developed


Input: Lower extremity arterial insufficiency after long-term methysergide maleate therapy.

Lower extremity arterial insufficiency

long-term methysergide maleate therapy

after


Input: Hepatolithiasis (intrahepatic stone) during octreotide therapy for acromegaly: a case report.

Hepatolithiasis (intrahepatic stone)

octreotide

during


Input: Acute unilateral total visual loss after retrogasserian phenol injection for the treatment of trigeminal neuralgia: a case report.

Acute unilateral total visual loss

retrogasserian phenol injection

after


Input: OBJECTIVE: Clozapine causes few extrapyramidal symptoms and is recommended as a treatment drug for severe tardive dyskinesia (TD).

Clozapine

few extrapyramidal symptoms

causes


Input: Methylphenidate-induced acute orofacial and extremity dyskinesia.

Methylphenidate

acute orofacial and extremity dyskinesia

induced


Input: Basilar invagination and mid-line skeletal abnormalities due to in utero exposure to phenytoin.

Basilar invagination and mid-line skeletal abnormalities

utero exposure to phenytoin

due


Input: DISCUSSION: To our knowledge, this is the first case report illustrating neuralgic amyotrophy triggered by exposure to the antibiotics vancomycin, tobramycin, and piperacillin/tazobactam.

neuralgic amyotrophy

antibiotics vancomycin, tobramycin, and piperacillin/tazobactam

triggered


Input: Alveolar-interstitial pneumopathy after gold-salts compounds administration, requiring mechanical ventilation.

Alveolar-interstitial pneumopathy

gold-salts compounds administration

after


Input: This study revealed that ketoconazole affected the disposition of rosiglitazone in humans, probably by the inhibition of CYP2C8 and CYP2C9, leading to increasing rosiglitazone concentrations that could increase the efficacy of rosiglitazone or its adverse events.

increasing rosiglitazone concentrations that could increase the efficacy of rosiglitazone or its adverse events

ketoconazole

humans

leading to


Input: We report a case of duloxetine-induced hyponatremia in an elderly patient treated with thiazide diuretics.

duloxetine

thiazide diuretics

hyponatremia

an elderly patient

induced


Input: Protamine-induced fatal anaphylaxis.

Protamine

anaphylaxis

fatal

induced


Input: We diagnosed this case as danazol induced thrombocytopenia.

danazol

thrombocytopenia

this case

induced


Input: One patient required nursing home placement and a feeding gastrostomy as a result of the worsening parkinsonism during risperidone treatment, but was able to return home and have the gastrostomy removed after switching from risperidone to clozapine.

One patient

required nursing home placement and a feeding gastrostomy as a result of the worsening parkinsonism

risperidone

treatment

One patient

was able to return home and have the gastrostomy removed

switching from risperidone to clozapine

after


Input: NMS is a drug-related response to various medications, such as Haloperidol, which the patient was receiving.

Haloperidol

patient

NMS

response


Input: In addition, ethambutol rarely causes visual loss during the early period or when given at lower doses.

ethambutol

during the early period or when given at lower doses

visual loss

causes


Input: The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.

behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused

day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d

he

stopped


Input: CONCLUSIONS: Hypersensitivity reactions to cyclosporine are due to Cremophor EL.

Hypersensitivity reactions to cyclosporine

Cremophor EL

due


Input: There are few reports in the literature related to sulfonylurea-induced hepatotoxicity.

sulfonylurea

hepatotoxicity

induced


Input: Radiation recall pneumonitis induced by gemcitabine.

Radiation recall pneumonitis

gemcitabine

induced


Input: Four days after the initial injection of 3.6 mg of goserelin acetate, severe dyspnea developed due to worsening pleuritis carcinomatosa, which was considered as a flare-up.

injection of 3.6 mg of goserelin acetate

severe dyspnea

worsening pleuritis carcinomatosa

severe

considered

developed


Input: Ropinirole was added to his current therapy for Parkinson disease, with a corresponding decrease in the dose of levodopa/carbidopa to allow levodopa sparing.

Ropinirole

a corresponding decrease in the dose of levodopa/carbidopa to allow levodopa sparing

added


Input: Recognizing early signs of HMSN, such as areflexia and pes cavus deformity, can prevent severe neurotoxicity of polychemotherapy by avoiding vincristine.

severe neurotoxicity of polychemotherapy

vincristine

severe

by


Input: This is the first report of pulmonary hypertension in an adult patient during lithium therapy.

an adult patient

lithium therapy.

pulmonary hypertension

during


Input: In this report, we present a case of hypoglycaemic coma associated with SP, an adverse reaction that is likely to be underreported and expected to occur with greater frequency as the use of SP increases.

hypoglycaemic coma

an adverse reaction that is likely to be underreported and expected to occur with greater frequency as the use of SP increases

SP

associated


Input: However, we have recently had four cases of clofibrate-induced myopathy in patients with diabetes insipidus due to hypothalamic lesions.

four cases

diabetes insipidus due to hypothalamic lesions

clofibrate

myopathy

induced


Input: One patient had MRI T2 abnormalities compatible with cyclosporin neurotoxicity.

One patient

cyclosporin

neurotoxicity

MRI T2 abnormalities

had


Input: Post-exposure prophylaxis for H1N1 with oseltamivir in renal allograft recipient--safe and effective without any immunosuppresive drug interaction.

oseltamivir

renal allograft recipient

safe and effective without any immunosuppresive drug interaction

Post-exposure prophylaxis


Input: Seven days after the introduction of amoxycillin (500 mg/8 h) for a probable respiratory infection, the patient developed spontaneous bruising, with an INR of 7.1.

Seven days after the introduction of amoxycillin (500 mg/8 h)

the patient

spontaneous bruising, with an INR of 7.1

developed


Input: To report a case in which significant hypotension occurred after initiation of tizanidine in a patient using the antihypertensive agent lisinopril.

hypotension

initiation of tizanidine

lisinopril

a patient

a case

after


Input: We herein describe a case of severe hyponatremia complicated by seizure and coma due to the intake of non-steroidal anti-inflammatory drugs (NSAIDs) in a patient on DDAVP replacement therapy for central diabetes insipidus (DI).

severe hyponatremia

seizure and coma

intake of non-steroidal anti-inflammatory drugs (NSAIDs)

on DDAVP replacement therapy

a patient

for central diabetes insipidus (DI)

severe

due to


Input: Each subject was treated according to the following sequence: baseline; phase 1 (days 1-6): cisapride 10 mg 4 times/day; washout (days 7-13); phase 2 (days 14-44): fluoxetine 20 mg/day; and phase 3 (days 45-52): cisapride 10 mg 4 times/day (days 45-51) plus fluoxetine 20 mg/day (days 45-52).

Each subject

baseline; phase 1 (days 1-6): cisapride 10 mg 4 times/day; washout (days 7-13); phase 2 (days 14-44): fluoxetine 20 mg/day; and phase 3 (days 45-52): cisapride 10 mg 4 times/day (days 45-51) plus fluoxetine 20 mg/day (days 45-52)

treated


Input: These findings are consistent with an immune-complex form of glomerulopathy in which gold is neither the antigen nor a hapten in the glomerular deposits, and they suggest the hypothesis that antibodies to tubular epithelial antigens induced by gold therapy may be a causative factor in the renal disease associated with gold therapy in rheumatoid arthritis.

gold therapy in rheumatoid arthritis

renal disease

may be

associated


Input: Induction of rapid mood cycling during L-dopa treatment in a bipolar patient.

rapid mood cycling

L-dopa

a bipolar patient

during


Input: To report a patient having a first-time seizure after receiving venlafaxine and trimipramine for depression.

venlafaxine and trimipramine

seizure

patient

receiving


Input: Paraplegia following prophylactic intrathecal cytosine arabinoside (Ara-C) is described in a patient with acute myelogenous leukemia in remission who received doses of 100 mg/m2/d for 5 consecutive days.

Paraplegia

prophylactic intrathecal cytosine arabinoside (Ara-C)

doses of 100 mg/m2/d for 5 consecutive days

a patient with acute myelogenous leukemia in remission

following


Input: Isoniazid induced gynaecomastia: a case report.

Isoniazid

gynaecomastia

induced


Input: One previous study of four transplant patients whose immediate post-transplantation immunosuppression utilized corticosteroids, cyclosporine, MMF, and anti-T-lymphocyte globulin noted anemia in 13% of them.

anemia

four transplant patients

immediate post-transplantation immunosuppression utilized corticosteroids, cyclosporine, MMF, and anti-T-lymphocyte globulin

noted


Input: Pleuropulmonary changes during treatment of Parkinson's disease with a long-acting ergot derivative, cabergoline.

cabergoline

Pleuropulmonary changes

during


Input: However, each infant demonstrated hemodynamic decompensation shortly after verapamil administration and required cardiopulmonary resuscitation.

each infant

hemodynamic decompensation

verapamil

demonstrated


Input: Long-term studies are needed to determine whether the insulin-sensitizing effects of the glitazones can prevent or delay premature atherosclerotic cardiovascular disease, morbidity, and death.

glitazones

prevent


Input: Probable propafenone-induced transient global amnesia.

propafenone

transient global amnesia

induced


Input: The patient continued to have fever and autonomic instability without evidence of infection which entirely resolved within 24 hours of reinstitution of full preadmission dosing of oral baclofen.

24 hours of reinstitution of full preadmission dosing of oral baclofen

fever and autonomic instability without evidence of infection which entirely resolved

have


Input: Traumatic late flap dehiscence and Enterobacter keratitis following LASIK.

LASIK

Traumatic late flap dehiscence and Enterobacter keratitis

following


Input: We report on a patient with subarachnoid haemorrhage who developed an acute life-threatening pseudo-obstruction of the colon, a variant of adynamic ileus, while being treated with intravenous nimodipine.

patient with subarachnoid haemorrhage

pseudo-obstruction of the colon

intravenous nimodipine

acute life-threatening

developed


Input: A 73-year-old woman presented with fever and cough 2 weeks after completing the third cycle of fludarabine for chronic lymphocytic leukemia (CLL).

A 73-year-old woman

fever and cough

2 weeks after completing the third cycle of fludarabine for chronic lymphocytic leukemia (CLL)

presented


Input: We report a case of myoclonus induced by quetiapine.

myoclonus

quetiapine

a case

induced


Input: A 21-year-old woman suffering from bipolar affective disorder developed systemic lupus erythematosus (SLE) with characteristic laboratory findings, 18 months after starting carbamazepine maintenance treatment.

A 21-year-old woman suffering from bipolar affective disorder

systemic lupus erythematosus (SLE)

18 months after starting carbamazepine maintenance treatment

developed


Input: Acyclovir produces neurologic symptoms that resemble extension of viral infection into the central nervous system.

Acyclovir

neurologic symptoms

produces


Input: Subcutaneous IL-2 is safe and well tolerated, with a mortality rate <3%.

Subcutaneous IL-2

mortality rate <3%

with


Input: Two patients with HLH developed etoposide-related secondary acute myeloid leukemia (sAML) following therapy for HLH.

Two patients with HLH

etoposide

secondary acute myeloid leukemia (sAML)

related


Input: We report a case of secondary glaucoma caused by epithelial downgrowth in which filtration surgery was performed with adjunctive use of subconjunctival 5-fluorouracil.

secondary glaucoma

epithelial downgrowth

filtration surgery was performed with adjunctive use of subconjunctival 5-fluorouracil

caused


Input: Mild serotonin syndrome associated with concurrent linezolid and fluoxetine.

concurrent linezolid and fluoxetine

serotonin syndrome

Mild

associated


Input: Risperidone versus clozapine in the treatment of psychosis in six patients with Parkinson's disease and other akinetic-rigid syndromes.

Risperidone versus clozapine

six patients with Parkinson's disease and other akinetic-rigid syndromes

treatment


Input: Hydroxyurea associated with concomitant occurrence of diffuse longitudinal melanonychia and multiple squamous cell carcinomas in an elderly subject.

Hydroxyurea

concomitant occurrence of diffuse longitudinal melanonychia and multiple squamous cell carcinomas

an elderly subject

associated


Input: Women (aged < or = 75 yr; > or = 2 yr since their last menstrual period) received placebo, RLX 60 mg/d, ALN 10 mg/d, or RLX 60 mg/d and ALN 10 mg/d combined.

Women (aged < or = 75 yr; > or = 2 yr since their last menstrual period)

RLX 60 mg/d, ALN 10 mg/d, or RLX 60 mg/d and ALN 10 mg/d combined

received


Input: Myoclonus and seizures in a patient with parkinsonism: induction by levodopa and its confirmation on SEPs.

Myoclonus and seizures

a patient with parkinsonism

levodopa

induction


Input: OBJECTIVE: To describe a probable case of transient global amnesia caused by propafenone.

transient global amnesia

propafenone

probable

caused


Input: We report the development of squamous-cell carcinoma within a basal-cell epithelioma that was treated with intralesional injections of 5-FU.

intralesional injections of 5-FU

squamous-cell carcinoma within a basal-cell epithelioma

treated


Input: This case report illustrates the use of continuous high-dose intracoronary nitroglycerin infusion through a 6 French coronary guiding catheter in the treatment of a patient with cocaine-induced refractory coronary vasospasm.

cocaine

refractory coronary vasospasm

induced

use of continuous high-dose intracoronary nitroglycerin infusion through a 6 French coronary guiding catheter

treatment


Input: Here, we describe levofloxacin-induced delirium with psychotic features in a relatively young, otherwise healthy female.

levofloxacin

delirium with psychotic features

relatively young, otherwise healthy female

induced


Input: Ticlopidine-induced phenytoin toxicity.

Ticlopidine

toxicity

induced


Input: Pancreatitis has been associated with the tetracycline class of antibiotics and concerns about tigecycline-induced acute pancreatitis have recently been raised.

acute pancreatitis

tigecycline

concerns

induced


Input: Abrupt, accidental withdrawal of trihexyphenidyl triggered severe exacerbation of the cranial dystonia associated with inspiratory stridor and acute respiratory difficulties, prompting emergency admission.

Abrupt, accidental withdrawal of trihexyphenidyl

exacerbation of the cranial dystonia associated with inspiratory stridor and acute respiratory difficulties

severe

triggered


Input: We report two patients with anhedonic ejaculation (ejaculation without orgasm) associated with initiation of treatment with desipramine.

two patients

desipramine

anhedonic ejaculation (ejaculation without orgasm)

associated


Input: We describe longitudinal diffusion-weighted MRI findings of sub-acute leukoencephalopathy following methotrexate therapy in a 24-year-old man diagnosed with pre-B-cell acute lymphoblastic leukemia (ALL), presenting with right-sided paralysis and aphasia after second consolidation with intrathecal triple-drug therapy given intrathecally.

longitudinal diffusion-weighted MRI findings of sub-acute leukoencephalopathy

methotrexate

a 24-year-old man

following

a 24-year-old man

second consolidation with intrathecal triple-drug therapy given intrathecally

presenting with right-sided paralysis and aphasia

after


Input: Therefore, although garenoxacin reportedly causes fewer adverse reactions for cardiac rhythms than third-generation quinolone antibiotics, one must be cautious of the interference of other drugs during hypokalemia in order to prevent TdP.

garenoxacin

adverse reactions for cardiac rhythms

fewer

causes

garenoxacin

hypokalemia

TdP

cautious

prevent


Input: A 45-year-old woman with steroid-dependent Crohn's colitis, successfully managed with maintenance infliximab infusions and methotrexate, developed a lupus-like syndrome eight months after her initial infusion.

A 45-year-old woman with steroid-dependent Crohn's colitis

lupus-like syndrome

maintenance infliximab infusions and methotrexate

eight months after her initial infusion

developed


Input: Severe neurotoxicity with methyl G: CALGB experience.

neurotoxicity

methyl G

Severe

with


Input: We report a case of a 60-year-old woman affected by squamous lung carcinoma, who developed paroxysmal supraventricular tachycardia during cisplatin and etoposide combination chemotherapy.

60-year-old woman affected by squamous lung carcinoma

paroxysmal supraventricular tachycardia

cisplatin and etoposide combination

developed


Input: The authors report a case of acute pancreatitis (AP) occurring in a patient under treatment with carbamazepine (CBZ) for post-traumatic petit mal epilepsy, and review the current literature of drug-induced AP.

acute pancreatitis

carbamazepine

a patient

occurring


Input: Acute ocular ischemic change may be associated with intravitreal injection of bevacizumab in patients with vascular compromised diabetic retinopathy and/or underlying stenosis of the carotid artery.

Acute ocular ischemic change

intravitreal injection of bevacizumab

patients with vascular compromised diabetic retinopathy and/or underlying stenosis of the carotid artery

associated


Input: All-trans-retinoic acid (ATRA) has been proved to be an effective treatment for acute promyelocytic leukemia (APL), inducing remission in more than 90% of cases.

All-trans-retinoic acid (ATRA)

more than 90% of cases

proved


Input: Vanishing bile duct and Stevens-Johnson syndrome associated with ciprofloxacin treated with tacrolimus.

Vanishing bile duct and Stevens-Johnson syndrome

ciprofloxacin

associated


Input: Antiasthmatic medications were prescribed, but the asthma symptoms did not improve.

Antiasthmatic medications were prescribed

not

improve


Input: Both 6-MP and AZA are widely used and are known to cause hepatotoxicity in a proportion of patients.

a proportion of patients

6-MP and AZA

hepatotoxicity

used


Input: Both raloxifene (RLX) and alendronate (ALN) can treat and prevent new vertebral fractures, increase bone mineral density (BMD), and decrease biochemical markers of bone turnover in postmenopausal women with osteoporosis.

Both raloxifene (RLX) and alendronate (ALN)

postmenopausal women with osteoporosis

increase bone mineral density (BMD)

decrease biochemical markers of bone turnover

treat


Input: We report a case of severe respiratory failure due to gold salt toxicity in a patient suffering from rheumatoid arthritis requiring mechanical ventilation.

respiratory failure

gold salt

a patient suffering from rheumatoid arthritis

severe

due


Input: We describe rupture of a cerebral arterial aneurysm in a 32 year old hypertensive woman following the introduction of nifedipine treatment.

rupture of a cerebral arterial aneurysm

a 32 year old hypertensive woman

nifedipine treatment

following


Input: Factors that suggested an association between the severe angioedematous reaction and BP topical application include the strong reaction to BP in the patch-test, the temporal relationship, the complete resolution of symptoms after the drug was withdrawn and the absence of other identified explanations.

severe angioedematous reaction

BP topical application

suggested

association


Input: RLX+ALN reduced bone turnover more than either drug alone, resulting in greater BMD increment, but whether this difference reflects better fracture risk reduction was not assessed in this study.

RLX

ALN

bone turnover more than either drug alone, resulting in greater BMD increment

reduced


Input: Hepatotoxicity related to itraconazole: report of three cases.

itraconazole

Hepatotoxicity

three cases

related


Input: This report presents a case of colon perforation which occurred 4 months after treatment with intraperitoneal chromic phosphate for stage IB ovarian papillary serous cystadenocarcinoma.

colon perforation

intraperitoneal chromic phosphate

occurred


Input: Flutamide withdrawal syndrome is characterized by a decrease in prostate-specific antigen (PSA) after flutamide withdrawal in a subset of patients with progressing metastatic carcinoma of the prostate.

flutamide

decrease in prostate-specific antigen (PSA)

subset of patients with progressing metastatic carcinoma of the prostate

withdrawal


Input: Bradycardia and congestive heart failure associated with ocular timolol maleate.

Bradycardia and congestive heart failure

ocular timolol maleate

associated


Input: CONCLUSIONS: Patients receiving intravitreal injections of bevacizumab should be evaluated for potential systemic risk factors such as carotid insufficiency, coagulopathy and poorly controlled diabetes mellitus.

carotid insufficiency, coagulopathy and poorly controlled diabetes mellitus

intravitreal injections of bevacizumab

risk


Input: Severe serotonin toxicity may result from metaxalone abuse in individuals using a selective serotonin reuptake inhibitor therapeutically.

serotonin toxicity

metaxalone abuse

using a selective serotonin reuptake inhibitor therapeutically

Severe

result


Input: The purpose of this article is to present the first case-series of posterior reversible encephalopathy syndrome (PRES) associated with L-asparaginase treatment.

L-asparaginase treatment

posterior reversible encephalopathy syndrome (PRES)

associated


Input: Eruptive epidermoid cysts resulting from treatment with imiquimod.

imiquimod

Eruptive epidermoid cysts

resulting


Input: Carbamazepine-related hyponatremia following cardiopulmonary bypass.

Carbamazepine

hyponatremia

related


Input: Fulminant hepatic failure is a rare complication of disulfiram treatment for alcoholism.

Fulminant hepatic failure

disulfiram

complication


Input: Implications: Clinicians should be aware of the possibility of increased toxicity of ropivacaine when used together with inhibitors of CYP1A2.

ropivacaine

inhibitors of CYP1A2

toxicity

possibility

increased


Input: Evidence obtained indicated that the Reye-like syndrome might be caused by calcium hopantenate possibly due to the induction of pantothenic acid deficiency.

Reye-like syndrome

calcium hopantenate

might

caused


Input: Hepatopathy subsided after the cessation of carbamazepine and lynestrenol.

carbamazepine

lynestrenol

Hepatopathy subsided

after


Input: This article presents a patient with hypoparathyroidism who was treated with calcium carbonate and calcitriol resulting in two admissions to the hospital for milk-alkali syndrome.

calcium carbonate and calcitriol

two admissions to the hospital for milk-alkali syndrome

a patient with hypoparathyroidism

resulting


Input: Recurrent hyponatremia associated with citalopram and mirtazapine.

Recurrent hyponatremia

citalopram and mirtazapine

associated


Input: A case report of a sharp rise in International Normalized Ratio (INR) values during a patient's concomitant use of warfarin and the antineoplastic agent vismodegib is presented.

a sharp rise in International Normalized Ratio (INR) values

a patient

concomitant use of warfarin and the antineoplastic agent vismodegib

during


Input: In this report we described a case of juvenile idiopathic arthritis patient who developed thymic enlargement (true thymic hyperplasia), mediastinal lymphadenopathy and pleurisy associated with systemic symptoms under Etanercept treatment.

a case of juvenile idiopathic arthritis patient

thymic enlargement (true thymic hyperplasia), mediastinal lymphadenopathy and pleurisy associated with systemic symptoms

Etanercept

developed


Input: A 52-year-old woman developed symmetric sensorimotor polyneuropathy and cerebellar syndrome after 24 months of amiodarone treatment.

A 52-year-old woman

symmetric sensorimotor polyneuropathy

cerebellar syndrome

amiodarone

developed


Input: The case of a patient under tibolone therapy for two years who developed a mixed-type liver injury with prolonged cholestasis and features of the vanishing bile duct syndrome following a ten weeks treatment with St. John wort (Hypericum Perforatum) infusions is reported.

under tibolone therapy

a ten weeks treatment with St. John wort (Hypericum Perforatum) infusions

a patient under tibolone therapy

a mixed-type liver injury with prolonged cholestasis and features of the vanishing bile duct syndrome

developed


Input: OBJECTIVE: To report a case of a diffuse papular eruption following treatment of psoriasis with methotrexate injections.

diffuse papular eruption

methotrexate injections

following


Input: Prolonged severe 5-fluorouracil-associated neurotoxicity in a patient with dihydropyrimidine dehydrogenase deficiency.

a patient with dihydropyrimidine dehydrogenase deficiency

neurotoxicity

severe

associated


Input: Life-threatening interstitial lung disease associated with trastuzumab: case report.

trastuzumab

Life-threatening interstitial lung disease

case

associated


Input: Thalidomide neuropathy is often associated with proximal weakness and may progress even after discontinuation of treatment, in the phenomenon of 'coasting'.

neuropathy

proximal weakness

Thalidomide

often

associated


Input: RESULTS: Our patient developed Crohn's disease while on Copaxone treatment as a consequence of long-term immunosuppression.

Crohn's disease

long-term immunosuppression

patient

Copaxone

developed


Input: Acute vision loss after intravitreal injection of bevacizumab (avastin) associated with ocular ischemic syndrome.

Acute vision loss

ocular ischemic syndrome

intravitreal injection of bevacizumab (avastin)

after


Input: Development of persistent late onset asthma following treatment with captopril.

captopril

persistent late onset asthma

persistent

following


Input: Herein, we describe a patient with AIDS who presented to medical attention with pancytopenia 48 months postchemotherapy with etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab (R-EPOCH) for diffuse large B-cell lymphoma.

a patient with AIDS

48 months postchemotherapy with etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab (R-EPOCH)

medical attention with pancytopenia

presented


Input: However, prolongation of 5-FU half-life and an increase in INR have been reported with the concurrent use of 5-FU and warfarin.

prolongation of 5-FU half-life and an increase in INR

the concurrent use of 5-FU and warfarin

reported


Input: Graves' hyperthyroidism following transient thyrotoxicosis during interferon therapy for chronic hepatitis type C.

Graves' hyperthyroidism following transient thyrotoxicosis

interferon

during


Input: We report a case of acute generalized exanthematous pustulosis (AGEP) in a 50-year-old woman that was attributed to the ingestion of nimesulide.

acute generalized exanthematous pustulosis (AGEP)

a 50-year-old woman

ingestion of nimesulide

attributed


Input: This case demonstrates the value of DWI in evaluation and diagnosis of sub-acute toxic leukoencephalopathy in patients being treated with methotrexate.

sub-acute toxic leukoencephalopathy

methotrexate

patients

in


Input: We report the first histopathologically documented case of oral mucosa pigmentation after OLP treatment with topical tacrolimus.

topical tacrolimus

oral mucosa pigmentation

treatment


Input: Progressive hypoxemia mandated endotracheal intubation 1 week after rituximab administration and led to death 4 weeks after admission.

Progressive hypoxemia

led to death

rituximab administration

after


Input: Angiotensin converting enzyme blockers and their influence on the endothelial dysfunction, but the risk of hyperpotassemia are showed.

Angiotensin converting enzyme blockers

hyperpotassemia

risk

showed


Input: This is the first report of a fatal outcome from serotonin toxicity, precipitated by an interaction between methylene blue and venlafaxine.

methylene blue

venlafaxine

serotonin toxicity

fatal

precipitated


Input: A helicoidal CT scan showed diffuse and severe interstitial pneumonitis, and lung biopsy confirmed accelerated usual interstitial pneumonia consistent with drug-induced toxicity.

diffuse and severe interstitial pneumonitis

accelerated usual interstitial pneumonia

toxicity

drug

induced


Input: We report a case of severe hypotension associated with intravenous valproate used to treat status epilepticus in an 11-year-old girl.

intravenous valproate

hypotension

an 11-year-old girl

severe

associated


Input: Relief by naloxone of morphine-induced spasm of the sphincter of Oddi in a post-cholecystectomy patient.

naloxone

post-cholecystectomy patient.

Relief

post-cholecystectomy patient.

morphine

spasm of the sphincter of Oddi

induced


Input: The results of the ultrasound examination combined with clinical anamnesis allowed diagnosis of gastric mucosa foveolar hyperplasia due to prolonged PGE1 therapy.

prolonged PGE1 therapy

gastric mucosa foveolar hyperplasia

due


Input: To our knowledge, no prior cases of penicillamine-induced TTP in RA have been reported.

penicillamine

TTP

no

induced


Input: Alternating sinus rhythm and intermittent sinoatrial block induced by propranolol.

Alternating sinus rhythm and intermittent sinoatrial block

propranolol

induced


Input: The noted increase in the theophylline level after zafirlukast administration is in contrast to the original reports by the manufacturer.

increase in the theophylline level

zafirlukast administration

after


Input: The cause is presumed to be secondary to hypercoagulability due to asparaginase-induced antithrombin III deficiency.

antithrombin III deficiency

asparaginase

presumed

induced


Input: Troglitazone-induced fulminant hepatic failure.

Troglitazone

fulminant hepatic failure

induced


Input: A sixty-year-old woman with advanced breast cancer, previously treated with cisplatin, developed an irreversible lethal renal failure with anuria, the day after 5 g/m2 bolus ifosfamide.

A sixty-year-old woman with advanced breast cancer, previously treated with cisplatin

an irreversible lethal renal failure with anuria

the day after 5 g/m2 bolus ifosfamide

irreversible

developed


Input: With the negative viral serologies, the clinical picture was most consistent with an infectious mononucleosis-like syndrome produced by the minocycline ingestion.

minocycline ingestion

infectious mononucleosis-like syndrome

produced


Input: High-grade endometrial stromal sarcoma after tamoxifen therapy for breast cancer.

High-grade endometrial stromal sarcoma

tamoxifen

after


Input: We report here two cases of dyserythropoietic anaemia associated with long-term linezolid use that share striking similarities to chloramphenicol-associated myelotoxicity.

dyserythropoietic anaemia

long-term linezolid

associated


Input: Dipyrone-induced granulocytopenia: a case for awareness.

Dipyrone

granulocytopenia

a case

induced


Input: We report the case of a patient with chronic hepatitis C infection who developed severe anaemia during antiviral treatment with peginterferon alfa/ribavirin when oseltamivir was added to treat influenza.

severe anaemia

peginterferon alfa/ribavirin

oseltamivir

a patient with chronic hepatitis C infection

developed


Input: Both patients were then treated with a carboplatin alternative to cisplatin in the following courses, which resulted in neither a relapse of the colitis nor a recurrence of the malignancies up to this time.

Both patients

carboplatin

neither a relapse of the colitis nor a recurrence of the malignancies

neither

resulted


Input: It is rare to develop simultaneous toxicities while on anticonvulsants.

toxicities

anticonvulsants

develop


Input: Because of serious side effects of an increase in the QT interval causing torsades de pointes, dofetilide must be initiated with close monitoring of the QT interval in an inpatient setting.

dofetilide

QT interval causing torsades de pointes

serious

increase


Input: It should be emphasized that the recurrence of nephrotic syndrome was observed after the following chemotherapy, including M-CSF, whereas the bone marrow still remained completely remitted.

nephrotic syndrome

the bone marrow still remained completely remitted

chemotherapy, including M-CSF

after


Input: We present a patient with human immunodeficiency virus infection under treatment with foscarnet for CMV retinitis who complained of thirst and polyuria.

a patient with human immunodeficiency virus infection

foscarnet

thirst and polyuria

complained


Input: This represents the first report of nonconvulsive status epilepticus induced by ifosfamide.

nonconvulsive status epilepticus

ifosfamide

induced


Input: BACKGROUND: Headaches have been reported as a potential side effect of capecitabine therapy.

Headaches

capecitabine

of


Input: When DSCG was withdrawn, urticaria vanished and the child remained symptom-free.

urticaria vanished

symptom-free

DSCG was withdrawn

the child

remained


Input: Hepatotoxic effects in a child receiving valproate and carnitine.

Hepatotoxic effects

a child

valproate and carnitine

receiving


Input: We report a case of Graves' hyperthyroidism induced by long-term interferon (IFN) therapy.

Graves' hyperthyroidism

a case

long-term interferon (IFN) therapy

induced


Input: Bleomycin and cyclophosphamide toxicity simulating metastatic nodules to the lungs in childhood cancer.

Bleomycin and cyclophosphamide toxicity

metastatic nodules to the lungs

childhood cancer

simulating


Input: The patient presented with fulminant microangiopathic hemolytic anemia and thrombocytopenia within 48 hr of initiating therapy with trimethoprim-sulfamethoxazole.

The patient

fulminant microangiopathic hemolytic anemia and thrombocytopenia

within 48 hr of initiating therapy with trimethoprim-sulfamethoxazole

presented


Input: Pneumocystis pneumonia should be considered in asthmatic patients taking methotrexate who present with fever, pulmonary infiltrates, and hypoxia.

Pneumocystis pneumonia

fever, pulmonary infiltrates, and hypoxia

methotrexate

asthmatic patients

should

taking


Input: Acute respiratory distress syndrome after rituximab infusion.

Acute respiratory distress syndrome

rituximab infusion

after


Input: CONCLUSION: Gemcitabine-induced recall pneumonitis is a rarely reported phenomenon and should be taken into account even after extended time interval to the previous radiotherapy.

Gemcitabine

recall pneumonitis

induced


Input: In a 61-year-old man receiving chronic low-dosage amiodarone an interstitial pneumopathy was observed.

chronic low-dosage amiodarone

a 61-year-old man

interstitial pneumopathy

observed


Input: A 75-year-old man developed bilateral lower leg edema 6 months after switching from troglitazone to pioglitazone.

A 75-year-old man

bilateral lower leg edema

6 months after switching from troglitazone to pioglitazone

developed


Input: An acute ischaemic event associated with the use of venlafaxine: a case report and proposed pathophysiological mechanisms.

venlafaxine

An acute ischaemic event

a case

associated


Input: Oseltamivir was effective for post-exposure prophylaxis of H1N1 in close contact.

Oseltamivir

post-exposure prophylaxis


Input: Herein, we present a patient with severe and prolonged hypoglycemia after long-acting octreotide treatment.

long-acting octreotide treatment

a patient

severe and prolonged hypoglycemia

severe

after


Input: Worsening pneumonitis due to a pharmacokinetic drug-drug interaction between everolimus and voriconazole in a renal transplant patient.

a renal transplant patient

Worsening pneumonitis

pharmacokinetic drug-drug interaction between everolimus and voriconazole

due to


Input: Vocal cord paralysis as a consequence of peritonsillar infiltration with bupivacaine.

Vocal cord paralysis

peritonsillar infiltration with bupivacaine

consequence


Input: The sulfonamides are the best verified drug-trigger for erythema multiforme and Stevens-Johnson syndrome.

sulfonamides

erythema multiforme and Stevens-Johnson syndrome

drug-trigger


Input: Edema associated with ibuprofen therapy.

Edema

ibuprofen

associated


Input: A patient is presented with typical hyperthyroidism, who developed a severe proximal muscle weakness and a raised creatine phosphokinase after treatment for hyperthyroidism with propylthiouracil (100 mg orally, three times a day).

A patient is presented with typical hyperthyroidism

severe proximal muscle weakness and a raised creatine phosphokinase

treatment for hyperthyroidism with propylthiouracil (100 mg orally, three times a day)

severe

after


Input: Atorvastatin is the most potent of this class of agents currently available and is commonly used in the treatment of hyperlipidemia.

Atorvastatin

most potent

treatment


Input: However, there are few reports in the literature of ampicillin as a cause of acute interstitial nephritis.

ampicillin

acute interstitial nephritis

cause


Input: Optic neuropathy in ethambutol-treated renal tuberculosis.

Optic neuropathy

ethambutol

treated


Input: This case study describes an atypical case of refractory, sodium warfarin-induced necrotizing fasciitis and myonecrosis.

sodium warfarin

necrotizing fasciitis and myonecrosis

induced


Input: OBJECTIVE: To report a case of possible foscarnet-induced severe hypomagnesemia and other electrolyte disorders.

a case

foscarnet

severe hypomagnesemia and other electrolyte disorders

possible

induced


Input: However, the occurrence and management of akathisia induced by fluvoxamine have not been described.

akathisia

fluvoxamine

induced


Input: Nephrotic syndrome associated with interferon-beta-1b therapy for multiple sclerosis.

Nephrotic syndrome

interferon-beta-1b therapy

associated with


Input: OBSERVATIONS: A 48-year-old woman presented with disfiguring facial edema 10 weeks after she began antiviral therapy with peginterferon alfa-2a and ribavirin for chronic hepatitis C infection.

A 48-year-old woman

disfiguring facial edema

10 weeks

antiviral therapy with peginterferon alfa-2a and ribavirin

after


Input: Two of these patients, who also received the anti-emetic prochlorperazine, lost consciousness for 48-72 h and then fully recovered.

Two of these patients

anti-emetic prochlorperazine

lost consciousness for 48-72 h and then fully recovered

lost


Input: We present a depressive patient who developed mild parkinsonian signs and camptocormia after the introduction of olanzapine.

mild parkinsonian signs and camptocormia

introduction of olanzapine

depressive patient

mild

developed


Input: The case report discussed is, to our knowledge, the third of its kind regarding bone fluorosis resulting from use of this nicotinic derivative.

nicotinic derivative

bone fluorosis

use


Input: We report a case of Thrombotic Thrombocytopenic Purpura occurring as an allergic response to trimethoprim-sulfamethoxazole therapy (Bactrim, Septra) in a Jehovah's Witness patient.

Thrombotic Thrombocytopenic Purpura

allergic response

trimethoprim-sulfamethoxazole

Jehovah's Witness patient

to


Input: A 25-year-old white woman with chronic depression was treated with venlafaxine 150 mg/d and trimipramine 50 mg/d.

venlafaxine 150 mg/d and trimipramine 50 mg/d

A 25-year-old white woman with chronic depression

treated


Input: A 31-year-old female developed multiple episodes of grand mal seizures after combination chemotherapy with cisplatin, vinblastine and bleomycin for germ cell ovarian cancer stage Ic.

A 31-year-old female

multiple episodes of grand mal seizures

combination chemotherapy with cisplatin, vinblastine and bleomycin

developed


Input: Nephrogenic diabetes insipidus and renal tubular acidosis secondary to foscarnet therapy.

foscarnet

Nephrogenic diabetes insipidus and renal tubular acidosis

secondary


Input: PURPOSE: Topiramate-induced angle-closure glaucoma (TiACG) is believed to be related to its sulfonamide moiety.

Topiramate

angle-closure glaucoma (TiACG)

induced


Input: These toxicities resolved after the cessation of anticonvulsants, and her seizures were managed acutely with scheduled lorazepam.

lorazepam

managed


Input: This article reports the occurrence of rifampin-associated thrombocytopenia in an indigent patient after a four-month lapse in therapy for pulmonary tuberculosis.

rifampin

after a four-month lapse in therapy for pulmonary tuberculosis

thrombocytopenia

an indigent patient

associated


Input: Drug-induced psychosis resulted from the administration of quinacrine hydrochloride at a dosage of 100 mg twice daily for the treatment of discoid lupus.

administration of quinacrine hydrochloride at a dosage of 100 mg twice daily

psychosis resulted

induced


Input: We report a case of a scleroderma-like reaction induced by long-term administration of UFT.

a scleroderma-like reaction

long-term administration of UFT

a case

induced


Input: We report four cases of hemodynamically significant pericardial effusion in patients with refractory lymphoma who were receiving gemcitabine, all of whom had a history of mediastinal radiation without subcarinal blocking.

hemodynamically significant pericardial effusion

had a history of mediastinal radiation without subcarinal blocking

gemcitabine

in


Input: Both had impaired lung function and abnormal computed tomographic scans, and their condition improved when nitrofurantoin was withdrawn and corticosteroid treatment commenced.

nitrofurantoin was withdrawn and corticosteroid treatment commenced

Both had impaired lung function and abnormal computed tomographic scans

improved


Input: OBJECTIVE: The purpose of this study was to report the concomitant occurrence of multiple squamous cell carcinomas and diffuse nail hyperpigmentation associated with hydroxyurea treatment, and to describe a successful therapeutic approach using imiquimod 5%.

multiple squamous cell carcinomas and diffuse nail hyperpigmentation

hydroxyurea

associated


Input: We present a case report of a patient who developed a prolonged QT while being treated with oral methadone for a chronic pain syndrome.

oral methadone

prolonged QT

a patient

treated


Input: In this article, we describe a Japanese patient with severe interstitial pneumonia probably caused by sorafenib treatment for metastatic renal cell carcinoma.

a Japanese patient

severe interstitial pneumonia

sorafenib

severe

probably

caused


Input: Neurotoxicity occurs most often with intermittent high dose 5-FU as bolus injection or 24- to 48-h infusions.

Neurotoxicity

intermittent high dose 5-FU as bolus injection or 24- to 48-h infusions

occurs


Input: Lovastatin also reportedly has caused increases in INR when coadministered with warfarin.

Lovastatin

increases in INR

caused


Input: Pravastatin does not appear to interact with warfarin but has caused an increased INR when combined with the anticoagulant fluindione.

increased INR

Pravastatin

combined with the anticoagulant fluindion

not

caused


Input: Bromocriptine-induced schizophrenia.

Bromocriptine

schizophrenia

induced


Input: Pulmonary toxicity associated with erlotinib.

Pulmonary toxicity

erlotinib

associated


Input: Multicentric hepatocellular carcinoma following phosphate diethylstilbestrol therapy for prostatic cancer.

Multicentric hepatocellular carcinoma

phosphate diethylstilbestrol

following


Input: Rapid onset of quetiapine-induced diabetic ketoacidosis in an elderly patient: a case report.

quetiapine

diabetic ketoacidosis

an elderly patient

induced


Input: A 57-year-old woman developed pulmonary sarcoidosis during therapy with interferon beta for advanced renal cell carcinoma metastatic to mediastinal lymph nodes.

57-year-old woman

pulmonary sarcoidosis

interferon beta for advanced renal cell carcinoma metastatic to mediastinal lymph nodes

developed


Input: Mesalamine-induced hypersensitivity pneumonitis.

Mesalamine

hypersensitivity pneumonitis

induced


Input: A girl with cystic fibrosis and cyclic neutropenia developed an erythematous papular eruption without fever or neutrophilia 7 months after commencing therapy with G-CSF.

7 months after commencing therapy with G-CSF.

A girl with cystic fibrosis and cyclic neutropenia

erythematous papular eruption without fever or neutrophilia

developed


Input: Lichen planus and acne provoked by gold.

Lichen planus and acne

gold

provoked


Input: To the best of our knowledge only two previous cases of AML have been linked to treatment of HCL with purine analogs, both with 2-chlorodeoxyadenosine.

AML

purine analogs, both with 2-chlorodeoxyadenosine

linked


Input: There are no previous reports in the literature about the emergence of CML during treatment with hydroxyurea.

CML

treatment with hydroxyurea

during


Input: Intravenous valproate associated with significant hypotension in the treatment of status epilepticus.

Intravenous valproate

significant hypotension

associated


Input: Torsade de pointes associated with moxifloxacin: a rare but potentially fatal adverse event.

moxifloxacin

Torsade de pointes

fatal

associated


Input: We report serious adverse effects due to interaction between orally administered voriconazole and everolimus in a renal transplant recipient.

serious adverse effects

interaction between orally administered voriconazole and everolimus

a renal transplant recipient

due to


Input: Horner's syndrome and demyelinating peripheral neuropathy caused by high-dose cytosine arabinoside.

Horner's syndrome and demyelinating peripheral neuropathy

high-dose cytosine arabinoside

caused


Input: Fatal radiation myelopathy after high-dose busulfan and melphalan chemotherapy and radiotherapy for Ewing's sarcoma: a review of the literature and implications for practice.

radiation myelopathy

high-dose busulfan

melphalan

Fatal

after


Input: This is the first description, to our knowledge, of ductopenia apparently caused by clindamycin.

ductopenia

clindamycin

to our knowledge

caused


Input: Mefloquine-associated hypoglycaemia in a cachectic AIDS patient.

Mefloquine

hypoglycaemia

cachectic AIDS patient

associated


Input: Patients who commonly require linezolid as an antimicrobial are those with complex infections where other antibiotic treatment has failed.

Patients

complex infections

linezolid as an antimicrobial

require


Input: In three of these patients the infection was clinically unsuspected; in the fourth, cutaneous herpes zoster developed after administration of 300 mg of cytarabine daily for the preceding five days.

three of these patients

300 mg of cytarabine daily for the preceding five days

cutaneous herpes zoster

developed


Input: Patients receiving linezolid for more than 28 days should be monitored for signs of peripheral and optic neuropathy.

linezolid for more than 28 days

Patients

peripheral and optic neuropathy

should

monitored


Input: Atrioventricular block complicating amiodarone-induced hypothyroidism in a patient with pre-excitation and rate-dependent bilateral bundle branch block.

amiodarone

a patient with pre-excitation and rate-dependent bilateral bundle branch block

hypothyroidism

induced


Input: Lithium is known to cause acute renal failure and tubulo-interstitial disease, but the recently described association with proteinuria or nephrotic syndrome is little recognized.

Lithium

acute renal failure and tubulo-interstitial disease

proteinuria or nephrotic syndrome

association


Input: A 40-year-old man with advanced HIV infection and Mycobacterium avium complex infection experienced rapid cognitive decline after commencement of ethambutol, and symptoms fully resolved with cessation.

40-year-old man with advanced HIV infection and Mycobacterium avium complex infection

rapid cognitive decline

commencement of ethambutol

after


Input: Ciprofloxacin-induced hemorrhagic vasculitis is a rare side effect.

Ciprofloxacin

hemorrhagic vasculitis

induced


Input: Given that significant thyroid disorders may be only mildly symptomatic and thus may escape clinical detection, we suggest that thyroid function should be tested in any patient with otherwise unexplained changes in warfarin dose requirements, particularly if concomitantly treated with amiodarone.

significant thyroid disorders

warfarin

with amiodarone

changes


Input: Myotonia associated with sarcoidosis: marked exacerbation with pravastatin.

pravastatin

exacerbation

Myotonia

sarcoidosis

associated


Input: This observation questions the suitability of aspirin as prophylaxis for vascular disease in patients with meningiomas.

aspirin

patients with meningiomas

questions

prophylaxis


Input: Delayed neurotoxicity of intraventricular interleukin-2: a case report.

Delayed neurotoxicity

intraventricular interleukin-2

a case report

of


Input: We stress the potential of benzarone to cause hepatotoxicity, which usually resembles severe chronic active hepatitis.

hepatotoxicity

severe chronic active hepatitis

benzarone

potential

severe

cause


Input: We describe a patient with Wilson's disease who presented with neurologic disease, was treated with D-penicillamine, and suffered sudden neurologic deterioration coincident with therapy.

a patient with Wilson's disease who presented with neurologic disease

sudden neurologic deterioration

D-penicillamine

suffered


Input: We report the case of a 21-year-old female patient with dapsone hypersensitivity syndrome.

a 21-year-old female patient

dapsone

hypersensitivity syndrome

with


Input: The adverse events related to ribavirin and drug-drug interactions during therapy for hepatitis C are discussed.

ribavirin

adverse events

related


Input: Insulin-dependent diabetes mellitus developed in a young woman 8 weeks after the initiation of danazol for treatment of pelvic endometriosis.

8 weeks after the initiation of danazol

Insulin-dependent diabetes mellitus

a young woman

after


Input: Four cases of fat embolism are described in infants receiving prolonged intravenous infusion of fat (Intralipid 20%).

fat embolism

Four cases

infants

prolonged intravenous infusion of fat (Intralipid 20%)

receiving


Input: Oral adverse effects due to the use of Nevirapine.

Nevirapine

adverse effects

due


Input: PURPOSE: A case of probable enoxaparin-induced hepatotoxicity is described.

enoxaparin

hepatotoxicity

probable

induced


Input: Tizanidine was used again after her BP had stabilized, but did not produce similar problems.

Tizanidine

problems

not

produce


Input: It is suggested therefore that methotrexate be added to the list of agents capable of inducing diffuse interstitial pulmonary fibrosis.

methotrexate

diffuse interstitial pulmonary fibrosis

inducing


Input: The delayed encephalopathy developed 9 and 22 months respectively after the first dose of intrathecal methotrexate.

delayed encephalopathy

intrathecal methotrexate

developed


Input: Severe systemic hypersensitivity reaction to ibuprofen occurring after prolonged therapy.

ibuprofen

prolonged therapy

Severe systemic hypersensitivity reaction

Severe

after


Input: In patients with chronic heart failure, spironolactone added to conventional treatment may lead to serious and, occasionally, fatal hyperkalaemia.

spironolactone

patients with chronic heart failure

serious and, occasionally, fatal hyperkalaemia

may

lead


Input: We report a case of acute hyperphosphatemia secondary to rectal administration of sodium phosphate and sodium biphosphate (Fleet enema).

acute hyperphosphatemia

rectal administration of sodium phosphate and sodium biphosphate (Fleet enema)

secondary


Input: Visual changes secondary to initiation of amiodarone: a case report and review involving ocular management in cardiac polypharmacy.

Visual changes

amiodarone

a case

secondary


Input: This is the first case, to our knowledge, of onset of prolonged infliximab-induced lupus.

lupus

infliximab

induced


Input: A patient with developmental disabilities who had no history of movement disorders developed EPS following initiation of aripiprazole.

EPS

initiation of aripiprazole

A patient with developmental disabilities who had no history of movement disorders

following


Input: Case report: life-threatening hypoglycaemia associated with sulfadoxine-pyrimethamine, a commonly used antimalarial drug.

life-threatening hypoglycaemia

sulfadoxine-pyrimethamine

Case

associated


Input: Diphenhydramine-induced wide complex dysrhythmia responds to treatment with sodium bicarbonate.

treatment with sodium bicarbonate

to


Input: Prenatal cytomegalovirus (CMV) infection associated with severe brain damage was detected in an infant whose mother had been treated with prednisolone and azathioprine for systemic lupus erythematosus (SLE).

Prenatal cytomegalovirus (CMV) infection associated with severe brain damage

prednisolone and azathioprine

an infant whose mother had been treated with prednisolone and azathioprine for systemic lupus erythematosus (SLE)

treated


Input: Methotrexate may rarely provoke serositis, even with low doses and after just a few weeks of therapy.

Methotrexate

serositis

provoke


Input: Prescription analyses by pharmacists and literature research have permitted us to suggest that a drug-drug interaction between methotrexate and proton pump inhibitors (PPI) was responsible for this renal failure.

methotrexate and proton pump inhibitors (PPI)

renal failure

responsible


Input: Asthma and urticaria during disodium cromoglycate treatment.

Asthma and urticaria

disodium cromoglycate treatment

during


Input: We suggest that the previous classification of nitrofurantoin induced lung injury into "acute" and "chronic" injury is an oversimplification in view of the wide variety of pathological entities that have subsequently emerged.

nitrofurantoin

lung injury

induced


Input: Hepatitis with bridging fibrosis and reversible hepatic insufficiency in a woman with rheumatoid arthritis taking methotrexate.

methotrexate

a woman with rheumatoid arthritis

Hepatitis with bridging fibrosis and reversible hepatic insufficiency

taking


Input: Primary CNS lymphoma regressed on withdrawal of MM.

withdrawal of MM

Primary CNS lymphoma

regressed


Input: Pemphigus foliaceus induced by rifampicin.

Pemphigus foliaceus

rifampicin

induced


Input: L-T4 stimulated lymphocyte transformation in this patient.

lymphocyte transformation

this patient

stimulated


Input: A 53-year-old man developed lower leg edema 4 weeks after rosiglitazone was increased from 4 mg once/day to 4 mg twice/day.

A 53-year-old man

lower leg edema

4 weeks after rosiglitazone was increased from 4 mg once/day to 4 mg twice/day

after


Input: A mentally retarded 23-year-old woman with myoclonic astatic epilepsy developed an abnormal posture of extreme forward flexion, called camptocormia, during valproate monotherapy.

valproate

A mentally retarded 23-year-old woman with myoclonic astatic epilepsy

abnormal posture of extreme forward flexion, called camptocormia,

during


Input: After 5 days of treatment with IL-2, the patient developed a hemorrhagic lesion that progressed to toxic epidermal necrolysis, as well as grade 4 pancytopenia.

5 days of treatment with IL-2

patient

a hemorrhagic lesion that progressed to toxic epidermal necrolysis, as well as grade 4 pancytopenia

developed


Input: Acute pancreatitis after long-term 5-aminosalicylic acid therapy.

Acute pancreatitis

long-term 5-aminosalicylic acid therapy

after