Input: Interstitial pneumonitis and alveolar hemorrhage complicating use of rituximab: case report and review of the literature.

Interstitial pneumonitis and alveolar hemorrhage

rituximab

complicating


Input: We introduce a case of a sixty years old woman with several previous episodes of rhinitis, conjunctivitis and perspiration immediately after the administration of salmon calcitonin with nasal spray or intramuscular administration (Calsynar).

several previous episodes of rhinitis, conjunctivitis and perspiration immediately

salmon calcitonin with nasal spray or intramuscular administration (Calsynar)

a sixty years old woman

after


Input: In this article, we describe another case of subcutaneous changes following repeated glatiramer acetate injection, presented as localized panniculitis in the area around the injection sites, in a 46-year-old female patient who was treated with glatiramer acetate for 18 months.

subcutaneous changes

presented as localized panniculitis in the area around the injection sites

repeated glatiramer acetate injection

a 46-year-old female patient

following

a 46-year-old female patient

glatiramer acetate for 18 months

treated


Input: Eighty-two patients with various malignancies who received imipenem/cilastatin 143 times for neutropenic fever between March 1994 and October 1999 in Department of Pediatric Oncology, Gazi University, were identified.

Eighty-two patients with various malignancies

imipenem/cilastatin 143 times for neutropenic fever

received


Input: The present report first highlights the potentially life-threatening side effects associated with over-the-counter NSAIDs during DDAVP replacement therapy for central DI.

NSAIDs

potentially life-threatening side effects

associated with


Input: Case report: lack of control of diabetes and weight gain in a patient on initiation and rechallenge of therapy with olanzapine.

a patient

diabetes

weight gain

olanzapine

initiation and rechallenge


Input: Intravenous azithromycin-induced ototoxicity.

azithromycin

ototoxicity

induced


Input: Orally delivered PXD showed no evidence of clinical activity, when combined with weekly AUC2-carboplatin in PROC.

Orally delivered PXD

weekly AUC2-carboplatin

no

clinical activity


Input: We report such a series of patients who had transient asymptomatic bradycardia after being treated with continuous infusion 5-FU.

transient asymptomatic bradycardia

continuous infusion 5-FU

a series of patients

after


Input: Consolidation therapy with bortezomib/lenalidomide/ dexamethasone versus bortezomib/dexamethasone after a dexamethasone-based induction regimen in patients with multiple myeloma: a randomized phase III trial.

patients with multiple myeloma

Consolidation therapy with bortezomib/lenalidomide/ dexamethasone versus bortezomib/dexamethasone after a dexamethasone-based induction regimen

in


Input: Based on prior data suggesting that scheduling alterations of platinum would increase activity, the aim of the present study was to assess the potential therapeutic benefit of phenoxodiol (PXD), a novel biomodulator shown to have chemoresistance reversing potential, when combined with weekly AUC2-carboplatin in PROC patients.

phenoxodiol (PXD), a novel biomodulator shown to have chemoresistance reversing potential, when combined with weekly AUC2-carboplatin

potential therapeutic benefit

PROC patients

assess


Input: We also describe a new, noninvasive method to assess magnesium-induced neuromuscular block when curariform muscle relaxant was given simultaneously.

curariform muscle relaxant was given simultaneously

neuromuscular block

induced


Input: Our series of 3 patients supports a causal connection between bleomycin and scleroderma.

3 patients

bleomycin

scleroderma

supports


Input: In this paper, we report a patient with primary anti-phospholipid syndrome treated by corticosteroid, who developed disseminated nocardiosis.

a patient

corticosteroid

disseminated nocardiosis

developed


Input: Eye movement disorders in bone marrow transplant patients on cyclosporin and ganciclovir.

Eye movement disorders

bone marrow transplant patients

cyclosporin and ganciclovir

on


Input: Prolonged severe cholestasis induced by oxacillin derivatives.

Prolonged severe cholestasis

oxacillin derivatives

severe

induced


Input: Cisplatin was the common drug in the cases presented and therefore could be related to the INR elevations.

Cisplatin

the cases

INR elevations

could

related


Input: 5-Fluorouracil cardiotoxicity complicating treatment of stage IIB cervical cancer--case report.

cardiotoxicity

complicating


Input: RESULTS: A clinical diagnosis of fixed drug eruption owing to use of the PDE5 inhibitor tadalafil (Cialis) was made.

fixed drug eruption

PDE5 inhibitor tadalafil (Cialis)

owing


Input: Pancytopenia associated with 5-aminosalicylic acid use in a patient with Crohn's disease.

Pancytopenia

5-aminosalicylic acid

a patient with Crohn's disease

associated


Input: Fludarabine induced lung toxicity must be considered in all patients who develop unexplained lung disease while receiving fludarabine.

all patients who develop unexplained lung disease

Fludarabine induced lung toxicity

fludarabine

receiving


Input: Although other nitrites induce methemoglobinemia, exposure to methyl nitrite during phenylpropanolamine production appears to be a new cause of occupational methemoglobinemia.

methyl nitrite

occupational methemoglobinemia

appears to be

cause


Input: We report four cases of sensorimotor axonal neuropathy in children aged 10-15 years, treated with thalidomide for myxopapillary ependymoma, Crohn's disease and recurrent giant aphthous ulceration.

four cases

children aged 10-15 years

myxopapillary ependymoma, Crohn's disease and recurrent giant aphthous ulceration

sensorimotor axonal neuropathy

thalidomide

treated


Input: The patient died of respiratory failure after 8 days of steroid infusion and erlotinib discontinuation.

The patient

The

died of respiratory failure

8 days of steroid infusion and erlotinib discontinuation.

died

after


Input: Hypo-oestrogenic and anabolic/androgenic side-effects of danazol are well known by the gynaecologist and some of them are present in > 50% of patients being treated for endometriosis.

Hypo-oestrogenic and anabolic/androgenic

danazol

side-effects


Input: We believe that this is the first description of acute hepatitis caused by an idiosyncratic adverse reaction to gliclazide or to one of its metabolites.

acute hepatitis

gliclazide

idiosyncratic adverse reaction


Input: In view of our experience in the present case, it should be stressed that close monitoring of coagulation capacity is necessary in critically ill patients in order to avoid fatal haemorrhage after initiating warfarin therapy regardless of the dosage.

initiating warfarin therapy regardless of the dosage

haemorrhage

fatal

after


Input: We report a patient who developed acute pancreatitis during amiodarone therapy.

amiodarone

acute pancreatitis

a patient

during


Input: We report a 76-year-old man who developed an acute blistering eruption following high-dose penicillin treatment for pneumococcal septicaemia.

76-year-old man

acute blistering eruption

high-dose penicillin treatment

acute

developed


Input: OBJECTIVE: To report a case of colchicine-induced myopathy in a teenager with familial Mediterranean fever (FMF).

myopathy

a teenager with familial Mediterranean fever (FMF)

colchicine

induced


Input: We believe that mucositis was a contributing factor to this case of fatal hyperkalemia after administration of succinylcholine, with a mechanism similar to that reported with thermal injury.

succinylcholine

fatal hyperkalemia

mucositis

fatal

after


Input: Our experience supports hemodialysis for ESRF patients with atenolol toxicity.

ESRF patients with atenolol toxicity

hemodialysis

for


Input: Epirubicin-cyclophosphamide adjuvant chemotherapy plus tamoxifen administered concurrently versus sequentially: randomized phase III trial in postmenopausal node-positive breast cancer patients.

Epirubicin-cyclophosphamide adjuvant chemotherapy plus tamoxifen administered concurrently

postmenopausal node-positive breast cancer patients

administered


Input: Rupture of a cerebral aneurysm associated with nifedipine treatment.

nifedipine

Rupture of a cerebral aneurysm

associated


Input: An immediate hemolytic reaction induced by repeated administration of oxaliplatin.

immediate hemolytic reaction

repeated administration of oxaliplatin

induced


Input: Patient B developed perioral and upper extremity paresthesias during the fourth cycle of CAP alone (2500 mg/m2).

Patient B

perioral and upper extremity paresthesias

the fourth cycle of CAP alone (2500 mg/m2)

developed


Input: We describe four patients who had seizures while receiving ofloxacin; no other causes were evident.

ofloxacin

seizures

four patients

receiving


Input: The case history and toxicological findings of an infant fatality involving pseudoephedrine, brompheniramine, and dextromethorphan are presented.

pseudoephedrine, brompheniramine, and dextromethorphan

infant fatality

an infant

involving


Input: A drug interaction between zafirlukast and theophylline.

drug interaction

zafirlukast and theophylline

between


Input: Dipyrone, also known as metamizole, is an analgesic and antipyretic drug that was banned by the United States Food and Drug Administration because of its association with agranulocytosis.

agranulocytosis

Dipyrone, also known as metamizole

association


Input: A fatal case of pancytopenia due to levomepromazine.

pancytopenia

levomepromazine

A fatal case

due


Input: Reversible heart failure in a patient receiving etanercept for ankylosing spondylitis.

Reversible heart failure

a patient

etanercept

in


Input: The most likely cause of liver failure in this patient was, therefore, clarithromycin, which undergoes hepatic metabolism and has been reported to cause fulminant hepatic failure.

liver failure

clarithromycin

likely

cause


Input: Localized panniculitis and subsequent lipoatrophy with subcutaneous glatiramer acetate (Copaxone) injection for the treatment of multiple sclerosis.

Localized panniculitis and subsequent lipoatrophy

subcutaneous glatiramer acetate (Copaxone) injection

with


Input: glycopyrrolate (5.0 microg/kg) not only resulting in resolution of bradycardia but also resulting in an exaggerated increase of arterial blood pressure.

glycopyrrolate (5.0 microg/kg)

resolution of bradycardia

an exaggerated increase of arterial blood pressure

resulting


Input: This case underscores problems in clinical management with sulfadiazine hypersensitivity, potential immunosuppression from corticosteroids and selection of medications for recurrences of toxoplasmic chorioretinitis.

sulfadiazine

hypersensitivity

hypersensitivity

immunosuppression

corticosteroids

potential

from


Input: CONCLUSION: The results suggest that olanzapine may be useful in treating patients with clozapine-induced granulocytopenia without the risk of recurrence of hematologic side effects.

olanzapine

without the risk of recurrence of hematologic side effects

patients with clozapine-induced granulocytopenia

treating

clozapine

granulocytopenia

induced


Input: CONCLUSION: Patients with insulin allergy may not have complete resolution of their symptoms after standard desensitization, particularly those patients with concomitant protamine allergy.

standard desensitization

Patients with insulin allergy

concomitant protamine allergy

not

resolution


Input: To our knowledge, the syndrome of fever, pulmonary infiltrates, and pleural effusion following use of acyclovir has not been previously reported.

fever, pulmonary infiltrates, and pleural effusion

acyclovir

not

following


Input: We are concerned that the macular lesion was a retinal toxic effect of gentamicin because of the recent description of similar lesions occurring after the inadvertent intraocular injection of massive doses of this drug.

macular lesion

gentamicin

concerned

of


Input: Acute myocardial infarction during high-dose methylprednisolone therapy for Graves' ophthalmopathy.

high-dose methylprednisolone therapy

Acute myocardial infarction

Acute

during


Input: With itraconazole, hepatotoxic reactions have only very rarely been reported, and histologic data are lacking.

itraconazole

hepatotoxic

reported


Input: We describe in detail the first U.S. case report, of a 4(1/2)-year-old boy who experienced angioedema during treatment with oxcarbazepine.

oxcarbazepine

angioedema

a 4(1/2)-year-old boy

treatment


Input: Caution should be used when coadministering enfuvirtide and niacin to HIV-infected patients.

Caution

HIV-infected patients

coadministering enfuvirtide and niacin

used


Input: Several case reports of aplastic anemia with use of acetazolamide, and two cases with use of methazolamide, have appeared in the literature.

aplastic anemia

acetazolamide

Several case

reports


Input: SSRIs and fentanyl are commonly co-administered, especially in the setting of chronic or malignant pain, as underlying depression may contribute to the pathogenesis of pain.

SSRIs and fentanyl are commonly co-administered

in


Input: In this report we present four patients treated with a combination of different psychotropic drugs, in whom asterixis was triggered either by adding carbamazepine (CBZ) to a treatment regimen, or by increasing its dosage.

four patients

asterixis

carbamazepine

triggered


Input: Squamous-cell carcinoma arising in a basal-cell epithelioma treated with 5-fluorouracil.

Squamous-cell carcinoma arising

treated


Input: The case of a bipolar patient who developed thyrotoxicosis with severe exophthalmos while on lithium therapy is described.

lithium

The case of a bipolar patient

thyrotoxicosis with severe exophthalmos

severe

on


Input: The patient received only the ophthalmic sulfonamide, and it was used for one day, but he developed Stevens-Johnson syndrome.

ophthalmic sulfonamide, and it was used for one day

The patient

he

Stevens-Johnson syndrome

developed


Input: Papillary necrosis associated with the HIV protease inhibitor indinavir.

indinavir

Papillary necrosis

associated


Input: A case is reported of a 40 year old woman treated with intraventricular IL-2 for leptomeningeal disease who developed progressive cognitive dysfunction.

a 40 year old woman

intraventricular IL-2

progressive cognitive dysfunction

developed


Input: We document the abrupt development of an extensive choroidal detachment after initiation of dorzolamide therapy in a surgically untreated eye with primary open-angle glaucoma.

extensive choroidal detachment

dorzolamide therapy

surgically untreated eye with primary open-angle glaucoma

abrupt

extensive

development


Input: Serotonin toxicity as a consequence of linezolid use in revision hip arthroplasty.

Serotonin toxicity

linezolid use in revision hip arthroplasty

Serotonin

consequence


Input: Gallstones and bile sludge are common side effects of octreotide therapy but rarely become symptomatic or require treatment.

Gallstones and bile sludge

octreotide therapy

side effects of


Input: The authors' results suggest that L-dopa may cause daytime somnolence in some patients with Parkinson's disease.

some patients with Parkinson's disease

daytime somnolence

L-dopa

cause


Input: Seventy-four per cent of patients with epileptogenic disorders seen at the Emergency Unit at Groote Schuur Hospital were on phenytoin and 11.6% of these had blood levels in the toxic range.

blood levels in the toxic range

phenytoin

Seventy-four per cent of patients with epileptogenic disorders

11.6% of these

had


Input: Based on the history and clinical features, a diagnosis of insulin-induced lipohypertrophy was made.

insulin

lipohypertrophy

induced


Input: An unusual presentation of spontaneous sub-conjunctival haematoma in a patient receiving warfarin.

spontaneous sub-conjunctival haematoma

a patient

warfarin

in


Input: He developed congestive heart failure 5 days after administration of cyclophosphamide.

congestive heart failure

5 days after administration of cyclophosphamide

developed


Input: Fulminant liver failure associated with clarithromycin.

Fulminant liver failure

clarithromycin

associated


Input: Nifedipine may induce, or aggravate, pre-existing, gastro-oesophageal reflux.

Nifedipine

gastro-oesophageal reflux

induce, or aggravate


Input: Rifampin-associated thrombocytopenia secondary to poor compliance.

Rifampin

thrombocytopenia secondary to poor compliance

associated


Input: CONCLUSIONS: There was a temporal relationship between the onset of nonconvulsive status epilepticus and initiation of ifosfamide infusion.

onset of nonconvulsive status epilepticus

initiation of ifosfamide infusion

relationship


Input: Gemcitabine-induced pericardial effusion and tamponade after unblocked cardiac irradiation.

Gemcitabine

pericardial effusion and tamponade

induced


Input: Although useful in the management of chronic alcoholism, disulfiram is being increasingly associated with a wide spectrum of side effects and untoward medical sequelae, which now include catatonia.

disulfiram

a wide spectrum of side effects and untoward medical sequelae, which now include catatonia

associated


Input: DISCUSSION: The Naranjo probability scale indicated a probable relationship between sertraline treatment and the onset of rhabdomyolysis.

sertraline

rhabdomyolysis

probable

relationship


Input: Severe Raynaud's phenomenon with yohimbine therapy for erectile dysfunction.

Raynaud's phenomenon

yohimbine

Severe

with


Input: Possible theophylline toxicity during anesthesia.

anesthesia

theophylline toxicity

Possible

during


Input: Calcification and ossification of the spinal arachnoid after intrathecal administration of Depo-Medrol.

Calcification and ossification of the spinal arachnoid

intrathecal administration of Depo-Medrol

after


Input: Circulating anticoagulant in the procainamide-induced lupus syndrome.

procainamide

lupus syndrome

induced


Input: This report describes a case of bilateral ptosis induced by chloroquine.

a case

bilateral ptosis

chloroquine

induced


Input: When the data of the 57 patients are evaluated, a reversible direct cytotoxic effect of ticlopidine on the pluripotent/bipotent hematopoietic progenitor stem cell is proposed.

57 patients

cytotoxic effect

ticlopidine

proposed


Input: We report a child with yolk sac tumor who developed localized pigmentation after the first course of chemotherapy regimen that included cisplatin, etoposide and bleomycin.

a child with yolk sac tumor

localized pigmentation

the first course of chemotherapy regimen that included cisplatin, etoposide and bleomycin

after


Input: Except hypothyroidism after radioiodine treatment (euthyroid under substitutional therapy), she suffered from no other diseases.

hypothyroidism

radioiodine treatment (euthyroid under substitutional therapy)

she

after


Input: Late lethal hepatitis B virus reactivation after rituximab treatment of low-grade cutaneous B-cell lymphoma.

rituximab

Late lethal hepatitis B virus reactivation

after


Input: Despite the low dosage of warfarin, international normalized ratio (INR) was markedly elevated from 1.15 to 11.28 for only 4 days, and bleeding symptoms concurrently developed.

low dosage of warfarin

international normalized ratio (INR) was markedly elevated

bleeding symptoms

developed


Input: The possible role of interferon beta in the pathogenesis of sarcoidosis in this patient is discussed.

this patient

interferon beta

sarcoidosis

possible

role


Input: We hypothesize that a pharmacodynamic or pharmacokinetic drug interaction between venlafaxine and trimipramine involving the CYP2D6 isoenzyme may have played a role in inducing the seizures.

seizures

venlafaxine and trimipramine

may

hypothesize

inducing


Input: A case is described of severe splenic hemorrhage and rupture which developed 3 h after completion of tPA infusion for suspected acute myocardial infarction.

severe splenic hemorrhage and rupture

3 h after completion of tPA infusion

severe

developed


Input: Three weeks later, the decerebrate rigidity and high BP remained, and tizanidine was initiated to see whether the decrease in muscle tone could facilitate hypertension control and motor recovery.

decerebrate rigidity and high BP

tizanidine

hypertension control and motor recovery

to see whether

initiated


Input: CONCLUSIONS: The administration of prostaglandin E1 to neonates can cause gastric-outlet obstruction due to antral hyperplasia.

prostaglandin E1

neonates

gastric-outlet obstruction due to antral hyperplasia

cause


Input: During and after IFN therapy we should consider the possibility of occurrence of IDDM as well as other autoimmune diseases and observe the clinical course carefully.

IFN therapy

IDDM as well as other autoimmune diseases

occurrence


Input: In two of these cases akathisia resolved after withdrawal of olanzapine and substitution by a classical or an atypical neuroleptic agent, respectively.

withdrawal of olanzapine and substitution by a classical

neuroleptic agent

akathisia

two of these cases

resolved

akathisia

withdrawal of olanzapine and substitution by

an atypical neuroleptic agent

resolved


Input: Captopril-related (and -induced?) asthma.

Captopril

asthma

related


Input: These findings suggest that clozapine-induced seizures can be successfully treated, that gradual dose titration can reduce the likelihood of further episodes of seizures and that concomitant use of a suitable mood stabilizer/anti-epileptic medication can improve the outcome of treatment-resistant schizophrenia.

clozapine

seizures

induced

gradual dose titration

concomitant use of a suitable mood stabilizer/anti-epileptic medication

the likelihood of further episodes of seizures

improve the outcome of treatment-resistant schizophrenia

treated


Input: According to the Naranjo probability scale, the papular eruption was probably caused by methotrexate.

papular eruption

methotrexate

probably

caused


Input: The patient's defects may be due to methimazole teratogenicity or could represent a previously undescribed syndrome affecting ectodermal structures.

methimazole

teratogenicity

may

due


Input: CONCLUSIONS: Itraconazole-induced liver injury presents with a cholestatic pattern of injury with damage to the interlobular bile ducts, possibly leading to ductopenia.

Itraconazole

liver injury presents with a cholestatic pattern of injury with damage to the interlobular bile ducts, possibly leading to ductopenia

induced


Input: Rhabdomyolysis resulting from the drug interaction between diltiazem and other HMG-CoA reductase inhibitors has been described in the literature.

Rhabdomyolysis

diltiazem and other HMG-CoA reductase inhibitors

resulting


Input: Acute angioedema response to topical 5-fluorouracil therapy.

angioedema

response


Input: Hypersensitivity reactions due to chloramphenicol are rarely reported in the literature.

Hypersensitivity reactions

chloramphenicol

due


Input: Diagnosis of sclerosing glomerulonephritis occurred in this patient during anastrozole use, suggesting a newly defined side effect of anastrozole.

sclerosing glomerulonephritis

patient

anastrozole

suggesting

during


Input: A patient with coccidioidal meningitis was treated with intrathecally administered amphotericin B, and an acute toxic delirium with EEG abnormalities developed.

intrathecally administered amphotericin B

an acute toxic delirium with EEG abnormalities

A patient with coccidioidal meningitis

treated with


Input: This case raises important questions about non-ketotic, hyperosmolar diabetic coma with antipsychotics, the possible association between hyperglycaemia and hyperthermia, and the direction of causality in this, the recognition of either syndrome when they co-exist and management issues in such patients.

non-ketotic, hyperosmolar diabetic coma

hyperglycaemia and hyperthermia

antipsychotics

possible

association


Input: CONCLUSIONS: Reversible lupus-like syndrome appears to be a rare but significant side effect of 5-ASA compounds.

Reversible lupus-like syndrome

appears

side effect


Input: A patient with chronic myeloid leukaemia treated with busulphan for 4-5 years, developed signs of busulphan toxicity and portal hypertension with ascites, oesophageal varices and jaundice.

A patient with chronic myeloid leukaemia

busulphan for 4-5 years

busulphan toxicity and portal hypertension with ascites, oesophageal varices and jaundice

developed


Input: Several cases of lithium-induced Creutzfeldt-Jakob syndrome have been reported to date; all of them were elderly patients and a half had "therapeutic" lithium serum levels.

lithium

"therapeutic" lithium serum levels

Creutzfeldt-Jakob syndrome

elderly patients

induced


Input: There is, however, currently no data on the effect of combined hyperglycaemia and hyperinsulinaemia on the renal and ocular blood flow seen in diabetic patients on insulin therapy.

renal and ocular blood flow

combined hyperglycaemia and hyperinsulinaemia

diabetic patients

insulin therapy

no data

on


Input: Pemphigus vulgaris precipitated by glibenclamide therapy.

Pemphigus vulgaris

glibenclamide

precipitated


Input: Methimazole-associated cholestatic liver injury: case report and brief literature review.

Methimazole

cholestatic liver injury

associated


Input: The most likely cause of such hyponatremic episode is vinblastine.

vinblastine

hyponatremic episode

most likely

is


Input: Anti-tuberculous drugs had been stopped on the 2nd day of therapy due to development of optic neuritis secondary to ethambutol administration at another hospital.

optic neuritis secondary

ethambutol

to


Input: Based on this experience, we suggest that low-dose ketamine added to propofol may be associated with prevention of EA in children with a history of EA with propofol TIVA.

children with a history of EA with propofol TIVA

low-dose ketamine added to propofol

may

prevention


Input: Tetany in a child with AIDS receiving intravenous tobramycin.

Tetany

a child with AIDS

intravenous tobramycin

in


Input: Sideroblastic anemia due to linezolid in a patient with a left ventricular assist device.

Sideroblastic anemia

linezolid

patient with a left ventricular assist device

due


Input: Oral dapsone has been available for over 60 years and has been used to treat severe acne vulgaris; however, the oral formulation is known to cause dose-dependent haematological reactions and is currently indicated only for diseases such as dermatitis herpetiformis and Hansen's disease.

Oral dapsone

dose-dependent haematological reactions

cause


Input: Enalapril-induced anemia in two kidney transplant recipients.

Enalapril

two kidney transplant recipients

anemia

induced


Input: PURPOSE: To report two cases in which topical brimonidine resulted in apparent central nervous system depression and unresponsiveness in an infant.

topical brimonidine

apparent central nervous system depression and unresponsiveness

an infant

resulted


Input: BACKGROUND: Interferon beta has become standard therapy for reducing relapse frequency in relapsing/remitting Multiple Sclerosis (RRMS).

Interferon beta

standard therapy


Input: In this article lithium is not discussed, although there are a number of concerns about lithium's potential teratogenicity, and it has been implicated in Epstein's anomaly, a congenital heart defect among infants born to women taking lithium; as with other medications, however, the data have specific limitations.

lithium

Epstein's anomaly

implicated


Input: The risk of gastrointestinal bleeding during the treatment with antiagregants and anticoagulants, the risk of bradycardia in beta-blockade, possible interactions with other medications lowering the heart rate are discussed.

gastrointestinal bleeding

antiagregants and anticoagulants

risk

during

bradycardia

beta-blockade

risk

in


Input: Hepatotoxicity of paracetamol enhanced by ingestion of alcohol: report of two cases.

Hepatotoxicity

paracetamol

ingestion of alcohol

two cases.

enhanced


Input: Cancer patients who are receiving 5-FU treatment and are DPD deficient can develop severe side effects.

Cancer patients

are DPD deficient

receiving 5-FU

severe side effects

can

severe

develop


Input: A patient is described who developed a poorly differentiated sarcoma after cyclophosphamide was used to treat his rheumatoid arthritis.

A patient

his rheumatoid arthritis

poorly differentiated sarcoma

cyclophosphamide

developed


Input: Photo-onycholysis caused by olanzapine and aripiprazole.

Photo-onycholysis

olanzapine and aripiprazole

caused


Input: We observed 5 reactions in 3 patients that appear to be related to a high dose-infusion time ratio, indicating that dose and rate of infusion may be important factors in precipitating anaphylactoid reactions with cisplatin.

high dose-infusion time ratio

cisplatin

anaphylactoid reactions

3 patients

precipitating


Input: CONCLUSION: Fixed drug eruption is associated with many drugs but this is the first such report with omeprazole.

Fixed drug eruption

omeprazole

associated


Input: One type of SMON is associated with acrodermatitis enteropathica which has a very high frequency of occurrence in association with administration of clioquinol.

SMON

acrodermatitis enteropathica

clioquinol

a very high frequency

association


Input: We report a case of amiodarone-induced thyrotoxicosis of protracted duration, unresponsive to conventional thionamide therapy, with therapy limited by severe adverse drug reactions.

amiodarone

thyrotoxicosis

a case

induced


Input: The addition of ciprofloxacin to chronic simvastatin therapy led to the development of rhabdomyolysis.

ciprofloxacin

chronic simvastatin

rhabdomyolysis

led


Input: Nephropathy caused by methicillin therapy for staphylococcal septicemia.

Nephropathy

methicillin therapy for staphylococcal septicemia

caused


Input: Four patients in whom pulmonary oedema developed during tocolysis with hexoprenaline are described and the aetiological factors and pathogenesis of this potentially lethal complication discussed.

Four patients

pulmonary oedema

tocolysis with hexoprenaline

developed


Input: A case of skeletal fluorosis induced by prolonged treatment with niflumic acid, a fast-acting non-steroid antiinflammatory agent, is reported in a 35-year-old woman suffering from rheumatoid arthritis and treated, in addition, with corticosteroids.

niflumic acid

in addition, with corticosteroids

skeletal fluorosis

a 35-year-old woman suffering from rheumatoid arthritis

induced


Input: A 65-year-old man on warfarin therapy with a sudden spontaneous onset of sub-conjunctival haematoma associated with bloody tears was assessed in the clinic following a referral from an optometrist.

a sudden spontaneous onset of sub-conjunctival haematoma associated with bloody tears

A 65-year-old man

warfarin therapy

with


Input: This case report describes the development of asymptomatic visual field defects (VFDs) in a psychiatric patient with bipolar disorder receiving adjunctive tiagabine treatment.

tiagabine

patient

asymptomatic visual field defects

development


Input: Cardiorespiratory toxicity due to miconazole.

Cardiorespiratory toxicity

miconazole

due to


Input: Lovastatin-induced rhabdomyolysis possibly associated with clarithromycin and azithromycin.

clarithromycin

azithromycin

Lovastatin

rhabdomyolysis

possibly

induced


Input: For prevention of CYP2E1-mediated bioactivation, depending on protoxicant disposition, a second DSF dose might be necessary to completely prevent toxicity.

a second DSF dose

to


Input: We describe a patient with rheumatoid arthritis treated with gold salts, who developed bilateral interstitial pulmonary abnormalities and showed a dramatic response on corticosteroid therapy.

gold salts

bilateral interstitial pulmonary abnormalities

a patient with rheumatoid arthritis

treated with


Input: Pneumonitis is emerging as one of the most unpredictable and potentially serious, adverse effects of treatment with MTX.

MTX

Pneumonitis

potentially

with


Input: A chronic reaction associated with long-term treatment with nitrofurantoin has also been reported and causes irreversible pulmonary fibrosis.

long-term treatment with nitrofurantoin

irreversible pulmonary fibrosis

causes


Input: Nitrofurantoin-induced acute liver damage in pregnancy.

Nitrofurantoin

acute liver damage

pregnancy

induced


Input: A 58-yr-old male patient with essential thrombocythaemia (ET) developed chronic myeloid leukaemia (CML) after continuous uneventful treatment with hydroxyurea for 18 yr.

A 58-yr-old male patient with essential thrombocythaemia (ET)

chronic myeloid leukaemia (CML)

continuous uneventful treatment with hydroxyurea for 18 yr

developed


Input: A 64 year old man with recurrent metastatic squamous cell carcinoma of the head and neck developed severe skin rash and bone marrow aplasia 4 and 7 days, respectively, following a single dose of 40 mg/m2 methotrexate (MTX).

skin rash and bone marrow aplasia

a single dose of 40 mg/m2 methotrexate (MTX)

A 64 year old man with recurrent metastatic squamous cell carcinoma of the head and neck

severe

developed


Input: We present four cases in which the use of heparin was associated with hyperkalemia and discuss the pathophysiology.

four cases

heparin

hyperkalemia

associated


Input: Three cycles of chemotherapy had been administered without complications when, at the beginning of the fourth cycle, the patient developed clinical and laboratory abnormalities consistent with the development of the hemolytic-uremic syndrome.

hemolytic-uremic syndrome.

chemotherapy

at the beginning of the fourth cycle

the patient

developed


Input: Keratitis in methamphetamine abusers.

Keratitis

methamphetamine abusers

in


Input: A rechallenge, performed in both patients, confirmed the diagnosis of mesalamine-induced pancreatitis.

mesalamine

pancreatitis

both patients

induced


Input: Central nervous system toxicity associated with meperidine use in hepatic disease.

Central nervous system toxicity

meperidine

associated


Input: To our knowledge, this case is the first published report of levofloxacin-induced TEN.

levofloxacin

TEN

induced


Input: On the second day of hospitalization, it was noted that the patient's dyspnea and sinus bradycardia could be related to a recent increase in his timolol dosage.

dyspnea and sinus bradycardia

patient

a recent increase in his timolol dosage

could

related


Input: Three months following splenectomy, multiple abscesses occurred in the muscles of both thighs while the patient was receiving the third course of the CHOP regimen.

multiple abscesses occurred in the muscles of both thighs

the patient

Three months following splenectomy

third course of the CHOP regimen

while


Input: Methylene blue is used in a variety of surgical settings as well as for treatment of various types of hypotensive shock and methemoglobinaemia.

Methylene blue

treatment


Input: Methanol toxicity can cause severe central nervous system insult in which a characteristic pattern of bilateral putaminal injury is noted on brain imaging studies.

central nervous system insult

Methanol toxicity

severe

cause


Input: We believe that these skin eruptions belong to a spectrum of neutrophilic dermatoses that can be induced or aggravated by G-CSF therapy.

skin eruptions

G-CSF

believe

induced


Input: Although adverse reactions to protamine are reported infrequently and are usually mild, we recently observed the first fatal case of type I anaphylaxis resulting from protamine.

protamine

fatal case of type I anaphylaxis

fatal

resulting


Input: We have reported six cases of metoclopramide-induced parkinsonism seen in consultation over a two-year period.

six cases

metoclopramide

parkinsonism

induced


Input: Neutrophilic eccrine hidradenitis mimicking cutaneous vasculitis in a lupus patient: a complication of cyclophosphamide.

cyclophosphamide

Neutrophilic eccrine hidradenitis

a lupus patient

complication


Input: Gliclazide-induced acute hepatitis.

Gliclazide

acute hepatitis

induced


Input: A 16-year-old white male with acute biphenotypic leukemia developed evidence of the eosinophilia myalgia syndrome associated with total parenteral nutritional support with solutions containing tryptophan, which were given during his initial induction chemotherapy and also after autologous marrow transplantation.

A 16-year-old white male with acute biphenotypic leukemia

eosinophilia myalgia syndrome

total parenteral nutritional support with solutions containing tryptophan, which were given during his initial induction chemotherapy and also after autologous marrow transplantation

developed


Input: Subacute cholestatic hepatitis likely related to the use of senna for chronic constipation.

Subacute cholestatic hepatitis

use of senna

related to


Input: Palmar-plantar erythrodysaesthesia (PPE) is an uncommon cutaneous complication of cytotoxic chemotherapy which generally presents as a painful erythema involving the palms and soles.

Palmar-plantar erythrodysaesthesia (PPE)

an uncommon cutaneous complication

a painful erythema involving the palms and soles

cytotoxic chemotherapy

complication


Input: We report a case of an 11-year-old boy who experienced an anaphylactic reaction after administration of bacitracin ointment.

an 11-year-old boy

an anaphylactic reaction

after administration of bacitracin ointment

experienced


Input: The patient was found to have no motile sperm with a normal sperm count, while taking a dose of 400 mg/day of carbamazepine.

The patient

no motile sperm with a normal sperm count

400 mg/day of carbamazepine

found


Input: A fatal pancytopenia occurred in a patient with an history of depression with hypomanic rebounds, admitted for a manic episode and treated with levomepromazine, diazepam and lithium carbonate.

A fatal pancytopenia

a patient with an history of depression with hypomanic rebounds

treated with levomepromazine, diazepam and lithium carbonate

fatal

occurred


Input: Oxatomide is an antiallergic drug used for the treatment of diseases mediated by type I allergy.

Oxatomide

used


Input: Toxic hepatitis induced by disulfiram in a non-alcoholic.

Toxic hepatitis

disulfiram

a non-alcoholic

induced


Input: Accordingly, camptocormia is a dose-dependent side effect of valproate.

camptocormia

valproate

effect


Input: The uncomplicated long-term use of adequately-dosed AZA and stable non-toxic metabolite levels could not acknowledge TPMT deficiency as a primary cause of the leukopenia.

leukopenia

long-term use of adequately-dosed AZA and stable non-toxic metabolite levels could not acknowledge TPMT deficiency

cause


Input: CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.

65-year-old patient

confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome

chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram

following initiation of fentanyl

developed


Input: Such a case induced by hypothyroidism complicating long-term therapy with amiodarone in a 45 year old woman with pre-excitation is presented.

a 45 year old woman with pre-excitation

hypothyroidism

long-term therapy with amiodarone

complicating


Input: The diagnosis was based on the rapid onset of renal failure, presence of eosinophilia, skin rash, and characteristic renal biopsy finding, following the administration of ampicillin.

ampicillin

rapid onset of renal failure, presence of eosinophilia, skin rash, and characteristic renal biopsy

following


Input: 46-year-old woman developed painful ulcers over her lower abdomen in the form of reticulate erythema after injecting interferon beta-1b subcutaneously for multiple sclerosis.

46-year-old woman

painful ulcers over her lower abdomen in the form of reticulate erythema

injecting interferon beta-1b subcutaneously

developed


Input: Lupus-like syndrome caused by 5-aminosalicylic acid in patients with inflammatory bowel disease.

Lupus-like syndrome

5-aminosalicylic acid

patients with inflammatory bowel disease

caused


Input: Fatal acute tubular necrosis occurred in 1 patient in whom intravesical formalin was used to control massive persistent hemorrhage from radiation cystitis.

acute tubular necrosis

1 patient

intravesical formalin

Fatal

occurred


Input: The hypercalcemia responded to discontinuation of rhGH and a single dose of intravenous pamidronate disodium and has not recurred in 8 months of follow-up.

discontinuation of rhGH and a single dose of intravenous pamidronate disodium

has not recurred in 8 months of follow-up

responded


Input: The administration of "sweet spirits of nitre" (4% ethyl nitrite CH3CH2ONO in 70% ethyl alcohol) was followed by acute methemoglobinemia and severe anoxic metabolic acidosis in infant twins, Methylene blue administration reversed methemoglobinemia in both, but one twin died from the consequences of hypoxemia.

"sweet spirits of nitre" (4% ethyl nitrite CH3CH2ONO in 70% ethyl alcohol)

acute methemoglobinemia and severe anoxic metabolic acidosis

infant twins

followed

"sweet spirits of nitre" (4% ethyl nitrite CH3CH2ONO in 70% ethyl alcohol)

one twin

died from the consequences of hypoxemia

died

died

infant twins

Methylene blue

reversed


Input: The authors describe three families in whom the occurrence of FVS in all the siblings strongly suggests hereditary susceptibility to valproic acid-induced adverse outcome.

valproic acid-induced

three families

all the siblings

FVS

susceptibility


Input: We hypothesize that capecitabine-induced headache is vascular in nature.

capecitabine

headache

induced


Input: A lupus-like syndrome associated with infliximab therapy.

infliximab

A lupus-like syndrome

associated


Input: A case report of a patient with probable cisplatin and bleomycin-induced TMA is presented.

a patient with probable cisplatin

bleomycin

TMA

induced


Input: In some cases this seems to happen because spironolactone causes diarrhoea.

spironolactone

diarrhoea

seems

causes


Input: Painful neutrophilic skin lesions were observed in two children receiving granulocyte colony-stimulating factor (G-CSF) for treatment of idiopathic neutropenia.

two children

granulocyte colony-stimulating factor (G-CSF)

Painful neutrophilic skin lesions

observed


Input: Apparent central nervous system depression in infants after the use of topical brimonidine.

Apparent central nervous system depression

infants

topical brimonidine

after


Input: To our knowledge, this is the first report of insulin-induced lipohypertrophy with detailed histological examinations.

insulin

lipohypertrophy

induced


Input: Tigecycline-induced acute pancreatitis: case report and literature review.

acute pancreatitis

Tigecycline

induced


Input: Polymyositis is a rare complication of interferon alpha treatment as a result of immune-modulating role of the drug itself.

interferon alpha treatment

Polymyositis

complication of


Input: Sodium thiosulfate is a neutralizing agent for cisplatin that protects against renal damage.

Sodium thiosulfate is a neutralizing agent for cisplatin

protects against renal damage

protects


Input: Anaphylactic reaction to bacitracin ointment.

bacitracin ointment

Anaphylactic

reaction


Input: Severe bleomycin lung toxicity: reversal with high dose corticosteroids.

bleomycin

Severe bleomycin lung toxicity

Severe

toxicity


Input: CONCLUSIONS: Although mirtazapine offers clinicians a combination of strong efficacy and good safety, we suggest bearing SS in mind when prescribing this drug, especially in frail, elderly patients with underlying chronic conditions.

SS

frail, elderly patients with underlying chronic conditions

mirtazapine

bearing


Input: Five cases of clindamycin-associated pseudomembranous colitis in leukaemic patients are reported.

clindamycin

pseudomembranous colitis

leukaemic patients

associated


Input: Three days after receiving intravitreal injection of bevacizumab (1.25 mg in 0.1 ml), he developed acute vision loss and change of consciousness.

intravitreal injection of bevacizumab (1.25 mg in 0.1 ml),

acute vision loss and change of consciousness

he

developed


Input: The proposed cause of the nausea and anorexia was digoxin toxicity secondary to a drug-drug interaction with ciprofloxacin.

nausea and anorexia was digoxin toxicity

ciprofloxacin

proposed cause

secondary


Input: Mitomycin C (MMC) is an alkylating agent that has been recently associated with the hemolytic-uremic syndrome (HUS).

Mitomycin C (MMC)

the hemolytic-uremic syndrome (HUS)

associated


Input: Muscle biopsy revealed variation in muscle fiber size and few vacuolated fibers which were features of colchicine-induced myopathy.

colchicine

variation in muscle fiber size and few vacuolated fibers

myopathy

induced


Input: We describe a patient who developed NEH on three separate occasions provoked by two different chemotherapeutic agents--cytarabine and mitoxantrone.

cytarabine and mitoxantrone

NEH

a patient

provoked


Input: Orofacial dyskinesia appeared 5 hours after methylphenidate administration, persisted for 10 hours, and had completely resolved within 2 days.

Orofacial dyskinesia

5 hours after methylphenidate

appeared


Input: Present results suggested that coadministration of mexiletine increased blood tizanidine concentrations and enhanced tizanidine pharmacodynamics in terms of reduction in blood pressure and adverse symptoms.

tizanidine pharmacodynamics in terms of reduction in blood pressure and adverse symptoms

coadministration of mexiletine increased blood tizanidine concentrations

suggested

enhanced


Input: Bilateral acoustic (VIII) nerve palsy in this patient was most likely a manifestation of vincristine neurotoxicity.

Bilateral acoustic (VIII) nerve palsy

neurotoxicity

this patient

vincristine

most likely


Input: Acute leukopenia associated with silver sulfadiazine therapy.

Acute leukopenia

silver sulfadiazine

associated


Input: We describe two cases of PSVT that changed to non-sustained polymorphic ventricular tachycardia after administration of verapamil.

non-sustained polymorphic ventricular tachycardia

administration of verapamil.

two cases of PSVT

changed


Input: We described the occurrence of L-dopa-induced myoclonus and seizures in a case of parkinsonism with its SEPs findings.

L-dopa

myoclonus and seizures

case of parkinsonism

induced


Input: Retrospectively, bucillamine was believed to be the cause of the giant hypertrophy because of its structural similarity to D-penicillamine, which was the subject of an abundance of reports of mammary hyperplasia.

bucillamine

giant hypertrophy

cause of


Input: We speculate that platelet activation induced by pFVIII may have contributed to thrombosis and suggest that pFVIII be used with caution in elderly patients with pre-existing cardiovascular risk factors.

pFVIII

thrombosis

may

contributed


Input: Restoration of vancomycin susceptibility in Enterococcus faecalis by antiresistance determinant gene transfer.

Restoration of vancomycin susceptibility in Enterococcus faecalis

antiresistance determinant gene transfer

by


Input: Dental and gingival pain as side effects of niacin therapy.

Dental and gingival pain

niacin

side effects


Input: We describe a case of significant elevation of serum transaminases in a patient treated with 6-TG for a flare of Crohn's disease.

significant elevation of serum transaminases

a patient

elevation


Input: A patient developed transient, acute myopia while on isotretinoin (Accutane) therapy for acne.

acne

A patient

transient, acute myopia

isotretinoin (Accutane)

developed


Input: CONCLUSIONS: The pathogenesis of methotrexate-induced papular eruption in collagen vascular diseases may suggest cutaneous small-vessel vasculitis.

papular eruption

methotrexate

may

induced


Input: Aminophylline hypersensitivity apparently due to ethylenediamine.

Aminophylline hypersensitivity

ethylenediamine

apparently

due


Input: The main clinical features of this 58-year-old female patient were laboratory evidence of leucopenia and cholestasis, and biopsy features of fatty liver parenchyma degeneration with granulocytic portal infiltration and bile stasis, demonstrated 20 days after the initiation of antithyroid therapy with 20 mg methimazole daily.

antithyroid therapy with 20 mg methimazole daily

this 58-year-old female

leucopenia and cholestasis, and biopsy features of fatty liver parenchyma degeneration with granulocytic portal infiltration and bile stasis

demonstrated


Input: In one patient the vasculitis resolved after termination of the ciprofloxacin therapy; in the other patient the ciprofloxacin-induced hemorrhagic vasculitis was superimposed on a severe forefoot infection, leading to progressive gangrene and a below-knee amputation.

ciprofloxacin

hemorrhagic vasculitis was superimposed on a severe forefoot infection, leading to progressive gangrene and a below-knee amputation

patient

severe

induced

one patient the vasculitis

termination of the ciprofloxacin therapy

resolved


Input: Excluding other causes, Pentasa-associated pancytopenia was considered.

Pentasa

pancytopenia

associated


Input: RESULTS: A patient developed a bilaterally symmetric bull's-eye maculopathy 45 years after taking quinacrine for 18 months as prophylaxis against malaria.

A patient

bilaterally symmetric bull's-eye maculopathy

45 years after taking quinacrine for 18 months

developed


Input: Possible digoxin toxicity associated with concomitant ciprofloxacin therapy.

digoxin toxicity

ciprofloxacin

digoxin

Possible

associated


Input: The exophthalmos improved dramatically within 72 hours of the withdrawal of lithium.

within 72 hours of the withdrawal of lithium

improved


Input: We report two cases of neutropenia following captopril use in cardiac patients with trisomy 21.

two cases of

cardiac patients with trisomy 21

neutropenia

captopril use

following


Input: We report a case of hyponatremia associated with a grand mal seizure in a 28 month-old child after intra-nasal desmopressin administration for high fluid intake with nocturnal enuresis.

hyponatremia associated with a grand mal seizure

a 28 month-old child

intra-nasal desmopressin administration

after


Input: He developed fever, nausea, diarrhea, and malaise and stopped taking on the third day after commencing Pentasa.

Pentasa

fever, nausea, diarrhea, and malaise

He

developed


Input: Livedo reticularis associated with interferon alpha therapy in two melanoma patients.

two melanoma patients

interferon alpha therapy

Livedo reticularis

associated


Input: A 60-year-old woman with diabetes mellitus (type 2) developed an acute icteric hepatitis-like illness 6 weeks after the initiation of gliclazide therapy.

A 60-year-old woman with diabetes mellitus (type 2)

6 weeks after the initiation of gliclazide therapy

an acute icteric hepatitis-like illness

developed


Input: Thus cabergoline may cause similar pleuropulmonary abnormalities to bromocriptine.

bromocriptine

cabergoline

pleuropulmonary abnormalities

may

cause


Input: Although the existence of an acute pericarditis or an acute myocarditis as possible causes of the ST elevation cannot be fully ruled out, the sudden onset, prominent magnitude, and brief duration of the ST elevation are perhaps more indicative of an acute ischemic event, possibly related to a transient coronary vasoconstriction induced by the dopamine infusion.

transient coronary vasoconstriction

dopamine

induced


Input: Acute sensorineural hearing loss following intravenous ketoralac administration.

Acute sensorineural hearing loss

intravenous ketoralac

following


Input: Trimethoprim-sulfamethoxazole-induced hypersensitivity syndrome associated with reactivation of human herpesvirus-6.

Trimethoprim-sulfamethoxazole

hypersensitivity syndrome associated with reactivation of human herpesvirus-6

induced


Input: A patient is described who developed a rapid onset of pulmonary fibrosis following treatment with a new non-steroidal anti-inflammatory drug, nabumetone.

A patient

pulmonary fibrosis

nabumetone

developed


Input: To report a case of increased international normalized ratio (INR) in a geriatric patient receiving warfarin and ropinirole.

warfarin and ropinirole

a geriatric patient

increased international normalized ratio (INR)

case


Input: There is documentation of ocular toxicity with ethambutol when administered at dosages generally pronounced as being safe.

ocular toxicity

ethambutol

with


Input: k bipolar manic-depressive patient, developed while on lithium prophylaxis, akathisia at therapeutic serum lithium levels and subsequently bucco-linguo-masticatory dyskinesia.

lithium

at therapeutic serum lithium levels

k bipolar manic-depressive patient

bucco-linguo-masticatory dyskinesia

akathisia

developed


Input: We describe a patient who had a systemic allergic contact dermatitis to 8-MOP develop during her second course of PUVA treatment for psoriasis.

a patient

systemic allergic contact dermatitis to 8-MOP

PUVA

develop


Input: Seizures were treated with diazepam.

diazepam

treated


Input: Paradoxical seizures in phenytoin toxicity.

Paradoxical seizures

phenytoin toxicity

seizures


Input: CASE SUMMARY: Two children with attention deficit disorder treated with methylphenidate as a simple drug developed fixed drug eruption of the scrotum.

fixed drug eruption of the scrotum

Two children with attention deficit disorder

methylphenidate as a simple drug

developed


Input: While the patient was receiving both drugs, platelet aggregation studies revealed less platelet inhibition than would be expected in a patient not taking a concomitant inducer of ticagrelor metabolism.

less platelet inhibition than would be expected

a patient

taking a concomitant inducer of ticagrelor metabolism.

revealed


Input: Metformin-associated lactic acidosis precipitated by diarrhea.

Metformin

lactic acidosis

associated


Input: To date, only 1 death attributable to risperidone overdose has been reported.

death

risperidone overdose

attributable


Input: Systemic allergic contact dermatitis to 8-methoxypsoralen (8-MOP).

8-methoxypsoralen (8-MOP)

Systemic allergic contact dermatitis

to


Input: A case of a 21-year-old woman who had developed mild hepatotoxicity while receiving choline magnesium trisalicylate therapy is described.

a 21-year-old woman

mild hepatotoxicity

choline magnesium trisalicylate

receiving


Input: Early ritonavir-induced maculopapular eruption.

ritonavir

maculopapular eruption

induced


Input: In our patient, an objective causality scale showed that therapeutic doses of colchicine for FMF were the definite cause of myopathy, even though his renal and hepatic function were normal.

therapeutic doses of colchicine for FMF

our patient

his renal and hepatic function were normal

myopathy

cause


Input: Thrombocytosis induced by enoxaparin has been reported as a rare adverse effect of this medication in adults.

Thrombocytosis

enoxaparin

induced


Input: A woman with a 20-year history of acral pustular psoriasis of Hallopeau and recurrent pustular lesions of the forearms and lower legs, developed a B-cell lymphoma of the lip following 4 1/2 years of treatment with razoxane.

A woman with a 20-year history of acral pustular psoriasis of Hallopeau and recurrent pustular lesions of the forearms and lower legs

a B-cell lymphoma of the lip

4 1/2 years of treatment with razoxane

developed


Input: The evidence of high plasmatic levels of CBZ and the absence of other aetiologic factors lead the authors to conclude that the overdose of CBZ could have represented the precipitating of the episode of acute pancreatitis.

overdose of CBZ

acute pancreatitis

precipitating


Input: In this report, we describe a fatal gemcitabine-induced pulmonary toxicity in a patient with gallbladder metastatic adenocarcinoma.

gemcitabine

pulmonary toxicity

a patient with gallbladder metastatic adenocarcinoma

fatal

induced


Input: Progressive interstitial fibrosis with roentgenographic honeycombing developed in the case of a psoriatic patient who had been on a regimen of methotrexate for 18 years.

Progressive interstitial fibrosis with roentgenographic honeycombing

a psoriatic patient

a regimen of methotrexate for 18 years

developed


Input: In this report, one patient who developed gangrene after bleomycin and vincristine/vinblastine chemotherapy for AIDS-related Kaposi's sarcoma and another HIV-infected patient who exhibited symptoms of severe Raynaud's phenomenon related to the same regimen are presented.

one patient

gangrene

bleomycin and vincristine/vinblastine

severe

developed


Input: These multiple overlapping factors probably lead to rhabdomyolysis in a minority of patients receiving vasopressin infusion.

rhabdomyolysis

patients

vasopressin

lead


Input: Due to the increasing use of TMP-SMX in children, clinicians should be aware of this potentially life-threatening, immunemediated hypersensitivity reaction.

children

TMP-SMX

life-threatening, immunemediated hypersensitivity

potentially

life-threatening

reaction


Input: Given that discontinuation of nitrofurantoin and introduction of methylprednisolon therapy significantly lowered liver enzyme levels, restoring most of them to normal, we concluded that this was probably the case of toxic liver damage caused by nitrofurantoin.

toxic liver damage

nitrofurantoin

probably

caused


Input: Slow acetylators, who comprise roughly 50% of the South African population, are likely to develop clinical and biochemical features of phenytoin toxicity when this drug is given together with antituberculosis therapy.

phenytoin

together with antituberculosis

Slow acetylators

clinical and biochemical features of phenytoin toxicity

likely

develop


Input: Therefore there is the potential for significant concentration-related adverse effects when phenytoin is coadministered with other CYP2C9 substrates.

significant concentration-related adverse effects

phenytoin

other CYP2C9 substrates

potentia


Input: Putaminal infarct in methanol intoxication: case report and role of brain imaging studies.

methanol

Putaminal infarct in methanol intoxication

intoxication


Input: Progressive interstitial lung disease from prolonged methotrexate therapy.

Progressive interstitial lung disease

prolonged methotrexate therapy

from


Input: The case reported here is of a child given a large dose of intravenous iron sucrose (16 mg/kg) over 3 hours, who subsequently developed features of systemic iron toxicity.

a large dose of intravenous iron sucrose

systemic iron toxicity

a child

developed


Input: We report a patient with advanced colonic carcinoma who was treated with concomitant chemoirradiation with oxaliplatin and developed a peculiar dermnatitis in the irradiated field after being exposed to subsequent chemotherapy with oxaliplatin.

a patient with advanced colonic carcinoma who was treated with concomitant chemoirradiation with oxaliplatin

exposed to subsequent chemotherapy with oxaliplatin

a peculiar dermnatitis in the irradiated field

developed


Input: Recombinant human interferon-alpha has been used in the treatment of several cancers, but there have been several reports that it may exacerbate psoriasis or trigger off its onset.

Recombinant human interferon-alpha

exacerbate psoriasis

may

trigger


Input: This is the first case of HBV reactivation occurring during the year following rituximab monotherapy in the absence of any other immunosuppressive factor.

HBV reactivation

the year following rituximab monotherapy in the absence of any other immunosuppressive factor

occurring


Input: Systemic lupus erythematosus during penicillamine therapy for rheumatoid arthritis.

Systemic lupus erythematosus

penicillamine therapy

during


Input: In the absence of mucositis or diarrhea, severe dermatologic toxicity following a single low dose of the drug suggests an 'allergic' or acute hypersensitivity reaction to MTX in this patient.

dermatologic toxicity

an 'allergic' or acute hypersensitivity reaction

a single low dose of the drug

MTX

this patient

severe

following


Input: Erosion of psoriatic plaques after chronic methotrexate administration.

Erosion of psoriatic plaques

methotrexate

after


Input: Cardiac decompensation following verapamil therapy in infants with supraventricular tachycardia.

infants with supraventricular tachycardia

Cardiac decompensation

verapamil therapy

following


Input: We report two cases of tenofovir (TDF)-associated nephrotoxicity in perinatally HIV-infected adolescents.

tenofovir (TDF)

nephrotoxicity

perinatally HIV-infected adolescents

associated


Input: RESULTS: Including our own patient, a total of 26 cases of gemcitabine-associated HUS were identified.

gemcitabine

HUS

associated


Input: Even though only a few cases of this adverse event have been reported in the literature, severe docetaxel-induced pulmonary toxicity needs to be considered in the differential diagnosis when such patients present with respiratory symptoms.

docetaxel

pulmonary toxicity

respiratory symptoms

severe

induced


Input: In this article, the authors report a 7-year-old male patient who presented with orofacial and limb dyskinesia after his first dose of methylphenidate treatment for a diagnosis of attention-deficit/hyperactivity disorder; he was also receiving sodium valproate treatment for epilepsy.

a 7-year-old male patient

orofacial and limb dyskinesia

first dose of methylphenidate

after

a 7-year-old male patient

sodium valproate

receiving


Input: The first case concerns a 70-year-old man who developed severe aplastic anemia 7 weeks after treatment with 500 mg of ticlopidine daily.

70-year-old man

severe aplastic anemia

7 weeks after treatment with 500 mg of ticlopidine daily

developed


Input: CASE REPORT: A six-year-old boy with transfusion-dependent beta-thalassaemia developed a unilateral hearing loss shortly after commencing desferrioxamine therapy.

A six-year-old boy with transfusion-dependent beta-thalassaemia

a unilateral hearing loss

commencing desferrioxamine therapy

developed


Input: Syncope in a 65-year-old woman after nitrate ingestion.

Syncope

a 65-year-old woman

nitrate ingestion

after


Input: Both the longitudinal melanonychia and the multiple skin cancers first appeared after approximately 6 months of hydroxyurea treatment.

longitudinal melanonychia and the multiple skin cancers

approximately 6 months of hydroxyurea treatment

appeared


Input: Multifocal inflammatory leukoencephalopathy associated with levamisole therapy.

Multifocal inflammatory leukoencephalopathy

levamisole therapy

associated with


Input: The observation of cutaneous vasculitis during administration of propylthiouracil suggested that clinical awareness of this complication should be of considerable importance.

cutaneous vasculitis

propylthiouracil

during


Input: Physicians should be aware of the potential for developing a gemcitabine-induced radiation recall reaction resulting in hemodynamically significant pericardial effusion.

gemcitabine

radiation recall reaction resulting in hemodynamically significant pericardial effusion

induced


Input: OBJECTIVE: To describe a case of cefazolin-induced leukopenia in a critically ill patient who developed this adverse reaction upon rechallenge with cefoxitin.

cefazolin

leukopenia

a critically ill patient

induced


Input: The second patient suffered from high blood pressure, which was controlled with beta-blocker drugs.

The second patient suffered from high blood pressure

beta-blocker drugs

controlled


Input: The female patient received clozapine in a daily dose of 400 mg, which induced agranulocytosis after 2 months.

The female patient

agranulocytosis

clozapine in a daily dose of 400 mg

after 2 months

induced


Input: We report a case of interstitial pulmonary disease that occurred together with lymphocytic colitis during treatment with ticlopidine.

interstitial pulmonary disease

lymphocytic colitis

ticlopidine

a case

during


Input: Increased ocular pressure in two patients with narrow angle glaucoma treated with venlafaxine.

venlafaxine

Increased ocular pressure

two patients with narrow angle glaucoma

in


Input: Although they had complex medical problems, the high serum concentrations of ampicillin at the time of seizures without their recurrence after discontinuing the antibiotic suggest that the seizures were related to the ampicillin therapy.

seizures

ampicillin therapy

related


Input: Glaucoma secondary to epithelial downgrowth and 5-fluorouracil.

Glaucoma

secondary


Input: Of particular interest in this patient is the fluctuation of the QT interval at a stable dose of methadone, suggesting that a single normal electrocardiogram (ECG) does not guarantee that the patient is not at risk of ventricular arrhythmias.

fluctuation of the QT interval

this patient

a stable dose of methadone

at


Input: This is the first report of acute kidney injury due to zonisamide-induced DRESS/DIHS.

zonisamide

acute kidney injury due to

DRESS/DIHS

induced


Input: Although both the spontaneous occurrence of SLE and the psychosis as a sign of CNS involvement of SLE cannot be excluded, SLE could be considered as an adverse effect of carbamazepine.

SLE

carbamazepine

could

considered


Input: BACKGROUND: Cyanamide, an aversive agent widely used in Japan, is known to induce various degrees of hepatic lesion with ground-glass inclusion bodies.

various degrees of hepatic lesion with ground-glass inclusion bodies

Cyanamide

induce


Input: Oxcarbazepine-associated angioedema manifested by swelling of the face, eyes, lips, or tongue or difficulty swallowing or breathing (or both) is a rare but potentially life-threatening reaction for which early recognition and management are vital.

Oxcarbazepine

angioedema manifested by swelling of the face, eyes, lips, or tongue or difficulty swallowing or breathing (or both)

associated


Input: The combination therapy of interferon alpha and ribavirin was given to a 50-year-old female with CHC who had not responded to a previous treatment by interferon alpha.

a 50-year-old female with CHC who had not responded to a previous treatment by interferon alpha

combination therapy of interferon alpha and ribavirin

given


Input: Peripheral neuropathy associated with capecitabine.

Peripheral neuropathy

capecitabine.

associated


Input: DESIGN: We reviewed the medical records of four patients, who were seen by us between July 2000 and February 2004 for sudden onset of a central neurological syndrome within days of intrathecal MTX.

MTX

a central neurological syndrome

medical records of four patients

intrathecal


Input: Prothipendylhydrochloride-induced priapism: case report.

Prothipendylhydrochloride

priapism

induced


Input: Interstitial pneumonia probably associated with sorafenib treatment: An alert of an adverse event.

sorafenib treatment:

Interstitial pneumonia

probably

associated


Input: He had hypokalemia (K 2.3 mmol/L) induced by licorice and also had received disopyramide for arrhythmia, bicalutamide for prostate cancer, and silodosin for prostate hypertrophy.

hypokalemia (K 2.3 mmol/L)

licorice and also had received disopyramide for arrhythmia, bicalutamide for prostate cancer, and silodosin for prostate hypertrophy

induced


Input: Use of the Naranjo adverse drug reaction probability scale indicated a probable relationship (score of 5) between the patient's development of hepatotoxicity and the TMP-SMX therapy.

TMP-SMX therapy

hepatotoxicity

patient's

probable

development


Input: Since its introduction in 2012, vismodegib has been implicated as a possible factor in seven reports of patient deaths.

vismodegib

deaths

seven reports of patient

possible

implicated


Input: Acceleration of ventricular response to atrial flutter after intravenous adenosine.

intravenous adenosine.

Acceleration of ventricular response

after


Input: Possible induction of diabetes by treatment of hypertension with indapamide (with four case reports).

diabetes

indapamide

Possible

induction


Input: Physicians should be aware of the potential for the development of RS among children who are receiving long-term aspirin therapy for the treatment of systemic inflammatory illnesses.

RS

children

long-term aspirin therapy

potential

development


Input: While a lower systemic steroid dosage may have been the provoking factor, we feel that an adverse reaction to oleic acid, a dispersing agent in the aerosol freon vehicle, is a strong possibility.

oleic acid

adverse reaction

strong possibility

to


Input: Baclofen withdrawal syndrome resulting from underdosing of oral baclofen should be considered as a potential source of prolonged fever in the intensive care unit.

Baclofen withdrawal syndrome

prolonged fever in the intensive care unit

underdosing of oral baclofen

potential source

resulting


Input: We present a case of sotalol-induced bradycardia reversed by glucagon.

sotalol

bradycardia

a case

induced


Input: Hyperammonemia has been described as a complication of valproic acid therapy but may often be overlooked as a cause of lethargy in the postictal patient who presents to the emergency department.

Hyperammonemia

valproic acid therapy

complication


Input: Methylene blue has been found to be a potent inhibitor of monoamine oxidase (MAO), and several cases of serotonin toxicity have been reported recently following its administration.

Methylene blue

serotonin toxicity

several cases

following


Input: She had just finished a 3-week course of intravenous tobramycin for bronchiectasis and had an elevated serum tobramycin trough level 1 week before the onset of tetany.

a 3-week course of intravenous tobramycin

elevated serum tobramycin trough level 1 week before the onset of tetany

had


Input: In a postural challenge test after administration of isosorbide dinitrate (5 mg), blood pressure decreased from 120/67 to 65/35 mmHg, followed by syncope with a sudden decrease in pulse rate from 85 to 60 beats/min.

administration of isosorbide dinitrate (5 mg)

blood pressure decreased

syncope

a sudden decrease in pulse rate

after


Input: The condition improved slowly after stopping medication and systemic steroids.

steroids

condition improved

stopping


Input: Acetaminophen is a widely used analgesic that can cause acute liver failure when consumed above a maximum daily dose.

Acetaminophen

acute liver failure

cause


Input: Patients treated with 5-ASA compounds who experience acute inflammatory symptoms or clinical deterioration not related to their gastrointestinal disease should be screened to rule out a lupus-like reaction.

Patients

who experience acute inflammatory symptoms or clinical deterioration not related to their gastrointestinal disease

5-ASA compounds

lupus-like reaction

rule out

experience


Input: Successful treatment with arsenic trioxide of a patient with ATRA-resistant relapse of acute promyelocytic leukemia.

a patient with ATRA-resistant relapse of acute promyelocytic leukemia

arsenic trioxide

treatment


Input: Drug rash with eosinophilia and systemic symptoms after chlorambucil treatment in chronic lymphocytic leukaemia.

Drug rash with eosinophilia and systemic symptoms

chlorambucil

after


Input: She manifested all the clinical symptoms and signs of caffeine toxicity.

She

caffeine

all the clinical symptoms and signs of caffeine toxicity.

manifested


Input: Quinine-induced hearing loss.

Quinine

hearing loss

induced


Input: Ezetimibe-induced acute pancreatitis.

Ezetimibe

acute pancreatitis

induced


Input: We report a case of drug-induced pemphigus caused by an angiotensin-converting enzyme inhibitor, captopril.

pemphigus

captopril

a case

induced


Input: We conclude that low-dose HU therapy in patients with thalassemia intermedia may increase total Hb levels sufficiently to eliminate the need for transfusions.

in patients with thalassemia intermedia

low-dose HU therapy

increase total Hb levels

may

therapy


Input: There is the risk of convulsions occurring in susceptible patients following the use of the new anaesthetic agents which are capable of inducing CNS excitability.

convulsions

susceptible patients

the use of the new anaesthetic agents which are capable of inducing CNS excitability

occurring


Input: A patient with psoriasis is described who had an abnormal response to the glucose tolerance test without other evidence of diabetes and then developed postprandial hyperglycemia and glycosuria during a period of topical administration of a corticosteroid cream, halcinonide cream 0.1%, under occlusion.

postprandial hyperglycemia and glycosuria

a period of topical administration of a corticosteroid cream, halcinonide cream 0.1%, under occlusion

A patient with psoriasis is described who had an abnormal response to the glucose tolerance test without other evidence of diabetes

developed


Input: Although there is one case report of cholesterol crystal embolization following t-PA therapy with only extrarenal manifestations (N Engl J Med 321:1270, 1989), this is the first reported case of atheroembolic acute renal failure following t-PA therapy.

t-PA therapy

atheroembolic acute renal failure

following

t-PA

cholesterol crystal embolization

with only extrarenal manifestations

following


Input: A young woman developed galactorrhea during treatment with a new dibenzoxazepine antidepressant, amoxapine.

A young woman

galactorrhea

during treatment with a new dibenzoxazepine antidepressant, amoxapine

developed


Input: After ruling out a hydrotelluric source of fluorine, the patient's fluorosis was linked to chronic use of niflumic acid, following the publication in 1978 of the 2 previously reported cases affected by this drug.

fluorosis

the patient's

chronic use of niflumic acid

linked to


Input: The hospital course of the acute renal failure is presented with a review of the literature on cases of acute renal failure after IVIG.

acute renal failure

IVIG

after


Input: We report 3 cases of children with acute lymphoblastic leukemia who developed seizures and altered sensorium after L-asparaginase therapy.

3 cases of children with acute lymphoblastic leukemia

seizures and altered sensorium

L-asparaginase

after


Input: Caution with use of cimetidine in tolazoline induced upper gastrointestinal bleeding.

tolazoline

upper gastrointestinal bleeding

induced


Input: Other thiazolidinediones currently in clinical trials may be able to provide the therapeutic benefits of troglitazone without significant hepatotoxicity.

thiazolidinediones

provide


Input: OBJECTIVE: To report a case of neuroleptic malignant syndrome (NMS) associated with fluphenazine in a schizophrenic patient and review the literature related to this condition.

a case of neuroleptic malignant syndrome (NMS)

fluphenazine

schizophrenic patient

associated


Input: CONCLUSIONS: Because of its structural similarity to the other vinca alkaloids, vinorelbine is believed to be responsible for SIADH in our patient.

vinorelbine

SIADH

responsible


Input: Abnormal retinal function associated with isotretinoin therapy for acne.

Abnormal retinal function

isotretinoin

associated


Input: To our knowledge , this is the first reported case of bromide intoxication due to pyridostigmine bromide administration.

first reported case

bromide intoxication

pyridostigmine bromide

due


Input: In deciding if tamoxifen therapy is warranted, all potentially life-threatening adverse events associated with tamoxifen should be considered, including endometrial adenocarcinoma or uterine sarcoma.

tamoxifen

potentially life-threatening adverse events

including endometrial adenocarcinoma or uterine sarcoma

associated with


Input: We report the case of a patient with chronic lymphocytic leukemia (CLL) who developed fatal intravascular autoimmune hemolytic anemia (AIHA) after fludarabine treatment.

a patient with chronic lymphocytic leukemia (CLL)

fatal intravascular autoimmune hemolytic anemia (AIHA)

fludarabine treatment

after


Input: A 59-year-old woman with myasthenia gravis who received a large dose of pyridostigmine bromide developed postoperative psychosis and was diagnosed as having bromide intoxication.

a large dose of pyridostigmine bromide

postoperative psychosis and was diagnosed as having bromide intoxication.

A 59-year-old woman with myasthenia gravis

developed


Input: This is a report of a renal transplant patient with Pneumocystis pneumonia who developed chemical cellulitis and ulceration following the extravasation of intravenous pentamidine into the soft tissues of the left hand and forearm.

chemical cellulitis and ulceration

a renal transplant patient with Pneumocystis pneumonia

intravenous pentamidine into the soft tissues of the left hand and forearm

developed


Input: Attempts were made to stop and then restart the theophylline therapy at progressively lower doses; however, with each attempt, the patient's reaction to the drug became more toxic, with serum theophylline levels ranging between 99.9 and 149.9 micromol/L (18 and 27 microg/mL).

theophylline therapy

patient

reaction to the drug became more toxic

became


Input: Dyspnea, hypoxemia, and pleuritic chest pain occurred within 24 hours of rituximab administration, and there was no other apparent explanation.

Dyspnea, hypoxemia, and pleuritic chest pain

rituximab administration

occurred


Input: Dermatitis to captopril.

captopril

to


Input: Histological examination of the dacryolith suggested its derivation from breakdown products of adrenaline.

dacryolith

breakdown products of adrenaline

suggested

from


Input: Two patients developed diabetic coma when taking a combination of a thiazide diuretic and propranolol.

Two patients

diabetic coma

a combination of a thiazide diuretic and propranolol

developed


Input: Platinum-resistant ovarian cancer (PROC) constitutes a therapeutic dilemma with limited efficacy from traditional cytotoxic agents.

traditional cytotoxic agents

limited efficacy

from


Input: A patient suffering from heparin-associated thrombocytopenia (HAT), recurrent arteriothromboses, and acute renal failure after treatment with standard heparin is described.

standard heparin

thrombocytopenia (HAT), recurrent arteriothromboses, and acute renal failure

A patient

after


Input: Despite minimal short-term side effects and apparent efficacy, chronic treatment of MG with MM may be associated with increased risk of lymphoproliferative disorders.

MG with MM

increased risk of lymphoproliferative

may be

associated


Input: We report the case of a patient with multiple myeloma who developed acute life-threatening water intoxication following treatment with oral indomethacin and low dose intravenous cyclophosphamide.

acute life-threatening water intoxication

oral indomethacin and low dose intravenous cyclophosphamide

a patient with multiple myeloma

life-threatening

developed


Input: Multifocal electroretinographic abnormalities in ethambutol-induced visual loss.

ethambutol

visual loss

induced


Input: She was on etanercept and methotrexate for rheumatoid arthritis.

She

etanercept and methotrexate

for


Input: Central nervous system effects secondary to ciprofloxacin treatment are uncommon and usually consist only of minor dizziness or mild headache, although rare occurrences of seizures and hallucinations have been reported.

secondary to ciprofloxacin treatment

minor dizziness or mild headache, although rare occurrences of seizures and hallucinations

consist


Input: We present a case of a 20-year-old woman who ingested 900 mg of glyburide causing refractory hypoglycemia resistant to treatment with intravenous dextrose, glucagon, and diazoxide.

a 20-year-old woman

900 mg of glyburide

refractory hypoglycemia

ingested


Input: Etoposide-related myocardial infarction.

Etoposide

myocardial infarction

related


Input: Contrary to previous recommendations, our experience cautions against the further use of high-dose cytarabine in patients who develop PPE, and is a timely reminder of the potential toxicity of this agent, which is now increasingly being used as first-line treatment in the management of haematologic malignancies.

high-dose cytarabine

PPE

potential

toxicity


Input: She had been on Copaxone 20 mg/day treatment for 2 years when she first exhibited gastrointestinal symptoms.

Copaxone 20 mg/day treatment for 2 years

she

gastrointestinal symptoms

exhibited


Input: The authors present an elderly patient with mixed dementia who developed TD at multiple sites, (including respiratory dyskinesia [RD], limb dyskinesia, and orofacial dyskinesia) following abrupt withdrawal of risperidone therapy.

elderly patient with mixed dementia

TD at multiple sites, (including respiratory dyskinesia [RD], limb dyskinesia, and orofacial dyskinesia)

abrupt withdrawal of risperidone therapy

developed


Input: Interferon-based treatments have the potential to decrease the burden of disease, but are complicated by side effects, including neuropsychiatric symptoms.

Interferon

neuropsychiatric symptoms

potential

complicated


Input: Long-term efficacy of adding fenofibric acid to moderate-dose statin therapy in patients with persistent elevated triglycerides.

patients with persistent elevated triglycerides

adding fenofibric acid to moderate-dose statin therapy

efficacy


Input: Type 1 diabetes mellitus provoked by peginterferon alpha-2b plus ribavirin treatment for chronic hepatitis C.

peginterferon alpha-2b plus ribavirin treatment

Type 1 diabetes mellitus

provoked


Input: A 61-year-old man with early diffuse cutaneous scleroderma with myositis and progressive interstitial pneumonia developed generalized erythema with high fever 3 weeks after taking sulfamethoxazole/trimethoprim.

A 61-year-old man with early diffuse cutaneous scleroderma with myositis and progressive interstitial pneumonia

sulfamethoxazole/trimethoprim

generalized erythema with high fever

taking


Input: Serotonin toxicity caused by an interaction between fentanyl and paroxetine.

Serotonin toxicity

an interaction between fentanyl and paroxetine

caused


Input: The sub-conjunctival haematoma in a patient receiving warfarin can pose a significant management challenge.

sub-conjunctival haematoma

warfarin

receiving


Input: Toxic optic neuropathy associated with ethambutol: implications for current therapy.

ethambutol

Toxic optic neuropathy

associated


Input: The site of thrombosis and the chronological relationship with the IIR implicates a hypersensitivity to infliximab in the causation of the venous thrombosis in this case.

venous thrombosis

infliximab

causation


Input: One week after the initial-dose of adalimumab (160 mg), which was initiated due to an acute exacerbation of Crohn's disease, the patient developed a fulminant cardiomyopathy.

One week after the initial-dose of adalimumab (160 mg)

fulminant cardiomyopathy

an acute exacerbation of Crohn's disease, the patient

developed


Input: RESULTS: Ethambutol, and to a lesser extent isoniazid, are both implicated in the development of visually related side effects.

Ethambutol

isoniazid

visually related side effects

development


Input: We report a case of an inadvertent increase in the international normalized ratio (INR) after the addition of bismuth subsalicylate for the treatment of diarrhea in an enterally fed patient receiving warfarin therapy.

addition of bismuth subsalicylate

warfarin therapy

an enterally fed patient

inadvertent increase in the international normalized ratio (INR)

after


Input: Oral triazolam is potentially hazardous to patients receiving systemic antimycotics ketoconazole or itraconazole.

triazolam

hazardous

patients

potentially

to


Input: LFT elevation is transient and the low risk of the SB-LOT therapy to increase LFT value can be limited when risk factors are considered.

SB-LOT

risk

the low risk


Input: Nineteen cases of unusual enhanced vincristine neurotoxicity related to itraconazole have been reported in children.

Nineteen cases

children

unusual enhanced vincristine neurotoxicity

itraconazole

related


Input: Extended-release tolterodine 4 mg/day was then prescribed to manage overactive bladder.

Extended-release tolterodine 4 mg/day

prescribed


Input: Although it is difficult to be certain of the direct link of amiodarone on the basis of a single case, it is reasonable to presume that this histopathology is associated with amiodarone-induced hypothyroidism and that involution changes represent the hypofunctional status of this drug-induced disorder.

amiodarone

hypothyroidism

a single case

induced


Input: The present report describes the first case of acute pancreatitis associated with danazol treatment of endometriosis.

the first case

acute pancreatitis

danazol treatment of endometriosis

associated


Input: Awareness of this route of intoxication might be important in patients in whom neurologic or psychiatric symptoms develop while large amounts of lidocaine cream are being used.

neurologic or psychiatric symptoms

large amounts of lidocaine cream are being used

develop


Input: Cephalosporin-induced leukopenia following rechallenge with cefoxitin.

cefoxitin

Cephalosporin

leukopenia

induced


Input: Thrombotic thrombocytopenic purpura induced by trimethoprim-sulfamethoxazole in a Jehovah's Witness.

Thrombotic thrombocytopenic purpura

trimethoprim-sulfamethoxazole

a Jehovah's Witness

induced


Input: This eruption appears to be a distinct cutaneous toxicity of PLD.

eruption

distinct cutaneous toxicity

PLD

appears

of


Input: Granulocytopenia and agranulocytosis are considered among the most dangerous adverse effects of clozapine.

Granulocytopenia and agranulocytosis

clozapine

among


Input: RESULTS: We recently experienced a case of fatal erlotinib-induced ILD, diagnosed based on clinical and radiologic findings, which occurred in a patient with radiation fibrosis.

erlotinib

ILD

a patient with radiation fibrosis

fatal

induced


Input: Unusual hypersensitivity to warfarin in a critically ill patient.

warfarin

a critically ill patient

Unusual hypersensitivity

to


Input: Flumazenil reversal of benzodiazepine-induced sedation for a patient with severe pre-ECT anxiety.

benzodiazepine

sedation

a patient with severe pre-ECT anxiety

induced

a patient with severe pre-ECT anxiety

Flumazenil

reversal


Input: We report a case of seizure associated with L-asparaginase therapy but no evidence of hemorrhagic or thrombotic cerebrovascular events.

seizure

L-asparaginase therapy

associated


Input: Here we describe a patient with Crohn's disease who developed a severe infliximab infusion reaction (IIR), complicated 1 day later by severe swelling of the forearm and hand ipsilateral to the site of infliximab infusion.

a patient with Crohn's disease

infliximab infusion

severe infliximab infusion reaction (IIR), complicated 1 day later by severe swelling of the forearm and hand ipsilateral

developed


Input: She died within six weeks of developing congestive heart failure coupled with liver failure due to haemosiderosis despite regular use of desferrioxamine.

regular use of desferrioxamine

died within six weeks of developing congestive heart failure coupled with liver failure

died

despite


Input: A 56-year-old Caucasian man who received concomitant chemotherapy and radiation for head and neck cancer developed fever concurrent with the administration of amifostine.

A 56-year-old Caucasian man

fever

concomitant chemotherapy and radiation for head and neck cancer

concurrent with the administration of amifostine

developed


Input: In this study, we report on three individual patients who received BTX-B and who subsequently developed parasympathetic dysfunction of the visual system after injections of BTX-B at remote sites.

three individual patients

BTX-B

BTX-B

parasympathetic dysfunction of the visual system

developed


Input: Minocycline-induced autoimmune hepatitis is usually identical to sporadic autoimmune hepatitis.

Minocycline

autoimmune hepatitis

induced


Input: BACKGROUND: Reproductive endocrine disorders characterized by menstrual disorders, polycystic ovaries, and hyperandrogenism seem to be common among women treated with sodium valproate for epilepsy.

women

Reproductive endocrine disorders characterized by menstrual disorders, polycystic ovaries, and hyperandrogenism

sodium valproate for epilepsy

seem

treated


Input: Two cases of lepromatous leprosy with erythema nodosum leprosum who were on high doses of clofazimine, showed discoloration of nail plate, subungual hyperkeratosis and onycholysis.

Two cases of lepromatous leprosy with erythema nodosum leprosum

high doses of clofazimine

discoloration of nail plate, subungual hyperkeratosis and onycholysis

showed


Input: Doxycycline-induced photo-onycholysis.

Doxycycline

photo-onycholysis

induced


Input: Case report: acute renal failure after administering intravenous immunoglobulin.

acute renal failure

administering intravenous immunoglobulin

after


Input: Sweet's syndrome associated with sargramostim (granulocyte-macrophage colony stimulating factor) treatment.

sargramostim (granulocyte-macrophage colony stimulating factor) treatment

Sweet's syndrome

associated


Input: This is a rare case of ARDS associated with lithium intoxication.

ARDS

lithium

rare case

associated


Input: Intravenous haloperidol is generally well tolerated, but multiform ventricular tachycardia has been reported.

Intravenous haloperidol

multiform ventricular tachycardia

reported


Input: To report a case of rhabdomyolysis and acute hepatitis associated with the coadministration of atorvastatin and diltiazem.

coadministration of atorvastatin and diltiazem

rhabdomyolysis and acute hepatitis

associated


Input: Ten hours after the second methotrexate injection, the patient experienced a diffuse pruritic papular eruption located mainly on the limbs.

diffuse pruritic papular eruption located mainly on the limbs

the patient

Ten hours after the second methotrexate injection

experienced


Input: Flecainide and pharmacologically similar agents that interact with sodium channels may cause delirium in susceptible patients.

susceptible patients

delirium

Flecainide and pharmacologically similar agents that interact with sodium channels

may

cause


Input: An elderly man with procainamide hydrochloride-induced lupus syndrome had a circulating anticoagulant against factor XI and a biologic false-positive (BFP) test result for syphilis.

procainamide hydrochloride

lupus

An elderly man

induced


Input: In one patient, treatment with DCA was associated with a decrease in blood lactate levels from 11.2 mM before treatment to 0.8 mM 16 h later.

one patient

DCA

decrease in blood lactate levels

associated


Input: We report a case of noncardiogenic pulmonary edema developed after therapeutic trial of EO as sclerosing agent for esophageal varix.

noncardiogenic pulmonary edema

EO

developed


Input: That review suggested that patients receiving anti-D IGIV be monitored for those and other potential complications of hemoglobinemia, particularly disseminated intravascular coagulation (DIC).

patients

receiving anti-D IGIV

hemoglobinemia, particularly disseminated intravascular coagulation (DIC)

potential

complications


Input: Seizures associated with therapeutic doses of venlafaxine and trimipramine.

therapeutic doses of venlafaxine and trimipramine

Seizures

associated


Input: BACKGROUND: The risk/benefit ratio of warfarin therapy changes in the over 75s, when haemorrhagic side-effects become more common.

warfarin therapy

haemorrhagic side-effects

over 75s

become


Input: Norethisterone in these 69 pregnancies accounted for 33.3% (5 of 15) cases of clitoral hypertrophy diagnosed in 100,756 consecutive births.

Norethisterone

69 pregnancies

clitoral hypertrophy

accounted


Input: Interstitial fibrosis of the lung is a potential complication of methotrexate therapy for psoriasis.

Interstitial fibrosis of the lung

methotrexate

complication


Input: This is the first reported fatality due to this drug interaction and only the second case of serotonin syndrome reported with oxcarbazepine.

serotonin syndrome

oxcarbazepine

reported


Input: Purple glove syndrome, named for its distinctive purple discoloration and swelling of the hands in the distribution of a glove, is an uncommon complication of intravenous phenytoin administration through small dorsal veins of the hands.

Purple glove syndrome

purple discoloration and swelling of the hands in the distribution of a glove

intravenous phenytoin administration through small dorsal veins of the hands

complication


Input: Possible linkage of amprenavir with intracranial bleeding in an HIV-infected hemophiliac.

an HIV-infected hemophiliac

amprenavir

intracranial bleeding

Possible

linkage


Input: Inadvertent subsequent rechallenge with celiprolol led to recurrence of the pneumonitis, 10 weeks after drug readministration.

Inadvertent subsequent rechallenge with celiprolol

10 weeks after drug readministration

recurrence of the pneumonitis

led to


Input: Flecainide had been started 2 weeks prior for atrial fibrillation.

Flecainide

for


Input: In the absence of evidence of a potential role for concomitant medication i.e. hydroxychloroquine sulfate to play a role in the clinical, biochemical and morphological picture, an interaction between the herbal preparation and tibolone was suspected as the likely cause of liver damage.

an interaction between the herbal preparation and tibolone

liver damage

suspected

suspected


Input: Its overall toxicity is considerably less compared to standard induction chemotherapy; however, it is associated with a high incidence of a potentially fatal symptom complex referred to as "retinoic acid syndrome." This report describes a patient with APL who developed the syndrome a few weeks after initiating induction therapy with ATRA despite being treated for hyperleukocytosis.

a patient with APL

symptom complex referred to as "retinoic acid syndrome."

a few weeks after initiating induction therapy with ATRA despite being treated for hyperleukocytosis

fatal

developed


Input: During intravenous treatment with terlipressin for recurrent gastrointestinal (GI) bleeding, a 50-year-old male with no history of heart disease developed a newly prolonged QT interval and torsade de pointes.

a 50-year-old male with no history of heart disease

a newly prolonged QT interval and torsade de pointes

During intravenous treatment with terlipressin for recurrent gastrointestinal (GI) bleeding

developed


Input: It is concluded that chloral hydrate and methaqualone may be administered safely without additional caution in prothrombin test monitoring during oral anticoagulant therapy.

chloral hydrate and methaqualone

during oral anticoagulant therapy

may be

without

caution


Input: Amiodarone hydrochloride, a new antiarrhythmic agent, has been associated with pulmonary toxicity characterized by cough, dyspnea and diffuse pulmonary infiltrates.

Amiodarone hydrochloride

pulmonary toxicity characterized by cough, dyspnea and diffuse pulmonary infiltrates

associated


Input: Although major hazards of treatment of hypophosphatemic osteomalacia with phosphate and calcitriol are secondary hyperparathyroidism and vitamin D intoxication, potassium loss also should be kept in mind.

hypophosphatemic osteomalacia with phosphate and calcitriol

secondary hyperparathyroidism and vitamin D intoxication, potassium loss

major hazards


Input: He had priapism following the use of olanzapine.

priapism

olanzapine

following


Input: CONCLUSION: Our case shows a fatal side effect of erlotinib.

side effect

erlotinib

fatal

of


Input: Data have been published regarding the possibility that tamoxifen may be responsible for the subsequent development of carcinoma of the corpus uteri in these patients.

tamoxifen

subsequent development of carcinoma of the corpus uteri

these patients

may

responsible


Input: Corticosteroids may be useful for therapy of some features of this syndrome, such as thrombocytopenia.

Corticosteroids

may

be useful


Input: Eosinophilic cystitis after bladder instillation with dimethyl sulfoxide.

bladder instillation with dimethyl sulfoxide

Eosinophilic cystitis

after


Input: Beginning ductopenia was present in two, suggesting that itraconazole might be responsible for the occurrence of prolonged drug-induced cholangiopathy.

ductopenia

itraconazole

two

might be

responsible


Input: A 15-kg weight gain developed in a patient during the third week of ibuprofen therapy.

A 15-kg weight gain

a patient

ibuprofen

developed


Input: Cefoxitin-associated renal failure.

Cefoxitin

renal failure

associated


Input: The rash seen in this patient, who was treated with cephalexin, may be similar to the rash seen with ampicillin treatment of patients with infectious mononucleosis.

patient

cephalexin

rash

seen

ampicillin treatment

patients

infectious mononucleosis

seen


Input: Two of our patients developed TD after 23 months and 34 months of ziprasidone monotherapy, respectively.

Two of our patients

TD

ziprasidone

developed


Input: We describe two dark-skinned patients who developed hyperpigmented skin and tongue lesions during combination therapy with IFN and ribavirin.

combination therapy with IFN and ribavirin.

two dark-skinned patients

hyperpigmented skin and tongue lesions

during


Input: Attenuation of asparaginase-induced hyperglycemia after substitution of the Erwinia carotovora for the Escherichia coli enzyme preparation.

substitution of the Erwinia carotovora for the Escherichia coli enzyme preparation

Attenuation of asparaginase-induced hyperglycemia

after


Input: It remains to be seen whether the hepatotoxicity associated with troglitazone is a drug-class effect or specific to troglitazone.

hepatotoxicity

troglitazone

whether

associated


Input: Ampicillin-induced interstitial nephritis with generalised exfoliative dermatitis.

Ampicillin

interstitial nephritis with generalised exfoliative dermatitis

induced


Input: High-dose intravenous mannitol infusion in various clinical settings may result in acute renal failure (ARF).

High-dose intravenous mannitol infusion

acute renal failure

may

result