Input: DISCUSSION: Olanzapine, like other atypical antipsychotic drugs, may cause muscle injury with concomitant elevations of serum CK of muscle origin.

Olanzapine

atypical antipsychotic drugs

muscle injury with concomitant elevations of serum CK of muscle origin

may

cause


Input: Study 202 was an open-label, add-on study in patients with partial or generalized epilepsy treated with valproic acid (VPA), carbamazepine (CBZ), phenytoin (PHT), or topiramate (TPM) as monotherapy.

patients with partial or generalized epilepsy

valproic acid (VPA), carbamazepine (CBZ), phenytoin (PHT), or topiramate (TPM) as monotherapy

treated


Input: Dual antiplatelet therapy with aspirin and a P2Y12 receptor antagonist following placement of coronary stents is critical to prevent stent thrombosis and subsequent myocardial infarction.

aspirin and a P2Y12 receptor antagonist following placement of coronary stents

prevent


Input: Organometals also compromise the limbic system and result in deficits in learning and memory.

Organometals

compromise the limbic system

deficits in learning and memory

result


Input: Optic neuropathy associated with penicillamine therapy in a patient with rheumatoid arthritis.

Optic neuropathy

penicillamine

a patient with rheumatoid arthritis

associated


Input: We present the first case of ovarian endometrioid carcinoma and endometriosis in a postmenopausal patient who was treated with tamoxifen for breast cancer.

ovarian endometrioid carcinoma and endometriosis

postmenopausal patient

breast cancer.

tamoxifen

treated with


Input: There was a good correlation between the total dose of ACTH and the percentage decrease of brain parenchyma.

percentage decrease of brain parenchyma

total dose of ACTH

correlation


Input: We noted that the delirium resembled serotonin toxicity and that the patient had been taking paroxetine until 2 days before surgery.

paroxetine until 2 days before surgery

delirium resembled serotonin toxicity

taking


Input: Primary central nervous system lymphoma in a patient treated with natalizumab.

a patient

Primary central nervous system lymphoma

natalizumab

treated


Input: We retrospectively reviewed the records of 7 pediatric oncology patients who received low-dose ketamine in conjunction with propofol for total intravenous anesthesia (TIVA) repeatedly for radiation therapy.

7 pediatric oncology patients

low-dose ketamine in conjunction with propofol for total intravenous anesthesia (TIVA) repeatedly for radiation therapy

received


Input: We presume the cause for multiple organ failure could be the result of drug-drug interaction, atorvastatin and verapamil, as verapamil is known to increase the serum concentration of atorvastatin significantly.

multiple organ failure

interaction, atorvastatin and verapamil

presume

could

cause


Input: Hypersensitivity to zonisamide was confirmed by the skin patch test.

Hypersensitivity

zonisamide

to


Input: Pulmonary edema occurred 24 hours after intravenous ritodrine therapy and 10 hours after subcutaneous terbutaline therapy.

Pulmonary edema

24 hours after intravenous ritodrine therapy and 10 hours after subcutaneous terbutaline therapy

occurred


Input: Transient acute myopia resulting from isotretinoin (accutane) therapy.

Transient acute myopia

isotretinoin (accutane) therapy

resulting


Input: We report a case of fatal fulminant hepatitis caused by the use of disulfiram in a man with previously normal hepatocellular function.

a man

disulfiram

fatal fulminant hepatitis

fatal

caused


Input: OBJECTIVE: To describe two cases of rhabdomyolysis in patients taking lovastatin that were precipitated by the use of the newer macrolide antibiotics clarithromycin and azithromycin.

two cases

patients

rhabdomyolysis

lovastatin that were precipitated by the use of the newer macrolide antibiotics clarithromycin and azithromycin

taking


Input: Neutrophilic dermatoses in two children with idiopathic neutropenia: association with granulocyte colony-stimulating factor (G-CSF) therapy.

granulocyte colony-stimulating factor (G-CSF) therapy

two children with idiopathic neutropenia

Neutrophilic dermatoses

association


Input: The zinc/o-cymen-5-ol system has direct antimicrobial effects and inhibits oral disease-related processes.

zinc/o-cymen-5-ol system

antimicrobial effects

inhibits oral disease-related processes

inhibits


Input: Paroxetine is a selective serotonin reuptake inhibitor possessing anti-depressant activity.

Paroxetine

possessing


Input: A case of polymyositis with dilated cardiomyopathy associated with interferon alpha treatment for hepatitis B.

interferon alpha

A case

polymyositis with dilated cardiomyopathy

associated


Input: Phenytoin toxicity: an easily missed cause of cerebellar syndrome.

Phenytoin

cerebellar syndrome

cause


Input: Successful treatment of visceral leishmaniasis with allopurinol plus ketoconazole in an infant who developed pancreatitis caused by meglumine antimoniate.

an infant who developed pancreatitis caused by meglumine antimoniate

visceral leishmaniasis with allopurinol plus ketoconazole

treatment

pancreatitis

meglumine antimoniate

caused


Input: Hepatotoxicity after high-dose methylprednisolone for demyelinating disease.

Hepatotoxicity

high-dose methylprednisolone

after


Input: Interferon-alpha-induced focal segmental glomerulosclerosis in chronic myelogenous leukemia: a case report and review of the literature.

focal segmental glomerulosclerosis in chronic myelogenous leukemia

Interferon-alpha

induced


Input: Prior reports have emphasized the tubular and interstitial lesions associated with intermittent or discontinuous rifampin therapy for tuberculosis.

tubular and interstitial lesions

intermittent or discontinuous rifampin therapy

associated


Input: Transtentorial herniation caused by an intracranial mass lesion following high-dose methotrexate.

an intracranial mass lesion

Transtentorial herniation

high-dose methotrexate

following


Input: A case of prolonged suxamethonium apnoea successfully terminated by the infusion of a commercial preparation of serumcholinesterase is reported.

prolonged suxamethonium apnoea

the infusion of a commercial preparation of serumcholinesterase

terminated


Input: 53-year-old woman with a history of deep vein thrombosis and pulmonary embolism was receiving warfarin to prevent thromboembolic complications; her international normalized ratio (INR) had been stable for 1 month.

53-year-old woman with a history of deep vein thrombosis and pulmonary embolism

warfarin

prevent


Input: OBJECTIVE: To describe a patient with asymptomatic bronchial asthma and hypertension who developed an acute asthma attack after receiving sustained-release verapamil.

sustained-release verapamil

a patient with asymptomatic bronchial asthma and hypertension

acute asthma attack

after


Input: Severe hepatotoxicity related to benzarone: a report of three cases with two fatalities.

benzarone

hepatotoxicity

three cases

Severe

related


Input: We report on a 56-year-old female who exhibited drug refractory paroxysmal atrial fibrillation, in which marked prolongation of the QT interval and T wave inversion on electrocardiogram was demonstrated reproducibly shortly after the administration of oral pirmenol therapy.

a 56-year-old female

drug refractory paroxysmal atrial fibrillation, in which marked prolongation of the QT interval and T wave inversion

pirmenol

after


Input: Insulin-induced lipohypertrophy: report of a case with histopathology.

Insulin

lipohypertrophy

induced


Input: OBJECTIVE: To study therapy with indapamide impairing carbohydrate metabolism in essential hypertension patients and achieve earlier prevention, diagnoses and treatment of diabetes induced by indapamide.

indapamide

essential hypertension patients

study

therapy

diabetes

indapamide

induced


Input: We describe a patient with CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia) who paradoxically experienced worsening of Raynaud's phenomenon when using yohimbine for ED.

a patient with CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia)

worsening of Raynaud's phenomenon

yohimbine

experienced


Input: High-dose methotrexate-associated acute renal failure may be an avoidable complication.

High-dose methotrexate

acute renal failure

associated


Input: Chronic myelogenous leukemia (CML), hepatitis C, and interferon alpha (IFNalpha) have all been associated with renal dysfunction.

renal dysfunction

interferon alpha (IFNalpha)

associated


Input: CONCLUSIONS: Infectious endophthalmitis is a potential complication of intravitreal bevacizumab injection.

Infectious endophthalmitis

intravitreal bevacizumab injection

potential

complication


Input: RESULTS: One case of recurrent primary peritoneal carcinoma previously treated with a carboplatin-based regimen, developed a platinum hypersensitivity.

a carboplatin-based regimen

a platinum hypersensitivity

developed


Input: To our knowledge, these cases are the first published reports of lovastatin-induced rhabdomyolysis associated with azithromycin and clarithromycin.

lovastatin

associated with azithromycin and clarithromycin

rhabdomyolysis

induced


Input: Prick tests and intradermal tests with a series of dilutions of carboplatin and cisplatin were performed on three patients who had exhibited medium and severe hypersensitivity reactions to carboplatin.

carboplatin

medium and severe hypersensitivity reactions

three patients

medium and severe

exhibited


Input: A case of sideroblastic anemia is presented in a patient with a left ventricular assist device drive-line infection who was receiving linezolid, an antibiotic used for serious infections with gram-positive organisms.

sideroblastic anemia

a patient with a left ventricular assist device drive-line infection

receiving linezolid

presented


Input: Development of nephrotic syndrome in a patient with acute myeloblastic leukemia after treatment with macrophage-colony-stimulating factor.

macrophage-colony-stimulating factor

nephrotic syndrome

a patient with acute myeloblastic leukemia

after


Input: In patients with a known access to INH, seizures should be considered to be caused by INH toxicity unless proved otherwise.

INH

seizures

caused


Input: To our knowledge, this is the first case reported in the English literature of a generalized exanthem due to subcutaneous injection of enoxaparin.

subcutaneous injection of enoxaparin

generalized exanthem

the first case

To our knowledge

due


Input: This case illustrates the potential decoupling of PSA response from disease status in flutamide withdrawal.

potential decoupling of PSA response

flutamide withdrawa

illustrates


Input: Upon discontinuation of MTX, her ascites resolved, and her arthritis became more active.

discontinuation of MTX

her

resolved

discontinuation of MTX

her

arthritis became more active

active


Input: Colonic mucosal necrosis following administration of calcium polystryrene sulfonate (Kalimate) in a uremic patient.

Colonic mucosal necrosis

calcium polystryrene sulfonate (Kalimate)

uremic patient

administration


Input: Intracranial hemorrhage and focal seizures secondary to use of L-asparaginase during induction therapy of acute lymphocytic leukemia.

Intracranial hemorrhage and focal seizures

L-asparaginase

secondary to


Input: A fatal poisoning case involving etizolam, phenobarbital, promethazine and chlorpromazine is presented.

etizolam, phenobarbital, promethazine and chlorpromazine

A fatal poisoning

A fatal poisoning case

fatal

involving


Input: Rituximab-based therapy for gemcitabine-induced hemolytic uremic syndrome in a patient with metastatic pancreatic adenocarcinoma: a case report.

gemcitabine

hemolytic uremic syndrome

patient with metastatic pancreatic adenocarcinoma

induced


Input: Leukopenia due to parvovirus B19 in a Crohn's disease patient using azathioprine.

Leukopenia

parvovirus B19 in a Crohn's disease patient

azathioprine

due


Input: Fixed drug eruption of the scrotum due to methylphenidate.

Fixed drug eruption of the scrotum

methylphenidate

due


Input: Cytarabine-induced cerebellar syndrome: case report and literature review.

Cytarabine

cerebellar syndrome

induced


Input: We report a case of glaucoma induced by doxetaxel therapy for metastatic breast cancer.

a case

glaucoma

doxetaxel therapy for metastatic breast cancer

induced


Input: Myoclonus was induced and enhanced by L-dopa, developing into generalized seizures.

L-dopa

developing into generalized seizures

Myoclonus

induced and enhanced


Input: During analysis of 28 patients receiving CAP with concomitant radiation (XRT) for pancreatic cancer (resected or locally advanced), two patients developed signs and symptoms consistent with peripheral neuropathy.

CAP with concomitant radiation (XRT)

two patients

peripheral neuropathy

developed


Input: A liver biopsy in 2012 revealed marked fibrosis, leading the patient to start hepatitis C treatment with peginterferon alfa-2a, ribavirin and boceprevir.

fibrosis, leading the patient

peginterferon alfa-2a, ribavirin and boceprevir

treatment


Input: Knowledge regarding potential adverse effects of CAP is paramount and dose modification is indicated with development of neurotoxicity.

CAP

neurotoxicity

potential

adverse effects


Input: We present a case of significant over-anticoagulation temporally associated with a bout of protracted diarrhea in a patient on warfarin therapy.

protracted diarrhea

warfarin

over-anticoagulation


Input: New oral therapies for type 2 diabetes mellitus:

oral therapies

for


Input: The case histories are presented of two patients who developed lung disease associated with the use of nitrofurantoin with histological features of bronchiolitis obliterans organising pneumonia (BOOP), a rare but recognised form of drug induced injury.

the use of nitrofurantoin

two patients

lung disease

with histological features of bronchiolitis obliterans organising pneumonia (BOOP)

developed


Input: A 57-year-old woman with right bundle branch block +LPH and ventricular premature contractions developed complete heart block (CHB) following administration of disopyramide phosphate (Norpace).

A 57-year-old woman with right bundle branch block +LPH and ventricular premature contractions

complete heart block (CHB)

disopyramide phosphate (Norpace)

developed


Input: METHODS: In an institutional practice setting, two women, aged 25 and 45, developed acute myopia after starting topiramate for epilepsy.

two women, aged 25 and 45

acute myopia

topiramate

developed


Input: Diffusion-weighted MRI correlates of subacute methotrexate-related neurotoxicity.

subacute

neurotoxicity

methotrexate

related


Input: ARDS is rarely associated with rituximab infusion for lympho-proliferative disorders, but it should be considered by those administering rituximab, especially when a patient develops severe pulmonary symptoms soon after infusion.

a patient

ARDS

severe pulmonary symptoms

infusion

rituximab

after


Input: Seven of the eight cases of acute leukemia occurred in a series of 553 patients treated with Treosulfan for ovarian cancer in the period from 1970 to 1977 and followed closely for a total of 1159 patient-years up to February 1978.

acute leukemia

Treosulfan

Seven of the eight cases

occurred


Input: Desipramine-associated SIADH in an elderly woman: case report.

Desipramine

SIADH

an elderly woman

associated


Input: Can propofol precipitate pancreatitis in patients with Cushing's syndrome?

patients with Cushing's syndrome?

propofol

pancreatitis

Can

precipitate


Input: This case presents the possibility of anaphylaxis to topical 5-FU treatments and/or the interaction with angiotensin converting enzyme inhibitors.

anaphylaxis

angiotensin converting enzyme inhibitors

possibility

to


Input: After stopping indapamide, glucose tolerance impairing may be reversed.

indapamide, glucose tolerance impairing

may

stopping


Input: We describe a case of needle-track cutaneous seeding of hepatocellular carcinoma (HCC) after sonographically guided percutaneous ethanol injection (PEI).

needle-track cutaneous seeding of hepatocellular carcinoma

sonographically guided percutaneous ethanol injection

after


Input: Zidovudine use in pregnancy: a report on 104 cases and the occurrence of birth defects.

Zidovudine

birth defects

occurrence


Input: A patient with seropositive rheumatoid arthritis developed ascites while taking weekly doses of methotrexate (MTX).

A patient with seropositive rheumatoid arthritis

ascites

taking weekly doses of methotrexate (MTX)

developed


Input: High incidence of adverse events in healthy volunteers receiving rifampicin and adjusted doses of lopinavir/ritonavir tablets.

rifampicin and adjusted doses of lopinavir/ritonavir tablets

healthy volunteers

High incidence of adverse events

receiving


Input: We report here a case of TEN after administration of ciprofloxacin.

a case

TEN

ciprofloxacin

administration


Input: Zidovudine induced pure red cell aplasia: a case report.

Zidovudine

pure red cell aplasia

a case

induced


Input: A case of recall pneumonitis induced by gemcitabine is reported.

gemcitabine

recall pneumonitis

A case

induced


Input: Albuterol-induced hypokalemia and its potential cardiac toxicity are discussed briefly.

Albuterol

hypokalemia and its potential cardiac toxicity

induced


Input: In the absence of an ideal dose-intense FU monotherapy regimen, monthly FU with low-dose LV provides a simple and economical means by which to achieve adequate FU efficacy in the treatment of advanced colorectal cancer.

monthly FU with low-dose LV

treatment


Input: OBJECTIVE: To report a patient developing fulminant liver failure while being treated with clarithromycin for pneumonia.

fulminant liver failure

a patient

clarithromycin

treated


Input: The abnormal rhythm disappeared with the withdrawal of propranolol and when the drug was restarted a 2/1 S-A block was seen.

propranolol

2/1 S-A block

seen


Input: The Naranjo probability scale indicated a probable relationship between apnea and exposure to lamotrigine through breast-feeding in this infant.

apnea

lamotrigine through breast-feeding

in this infant

probable

a probable relationship


Input: Listeria brain abscess, Pneumocystis pneumonia and Kaposi's sarcoma after temozolomide.

temozolomide

Listeria brain abscess, Pneumocystis pneumonia and Kaposi's sarcoma

after


Input: Since amiodarone was first marketed in 1992 in Japan, the incidence of amiodarone-induced thyrotoxicosis (AIT) has been increasing.

amiodarone

thyrotoxicosis (AIT)

induced


Input: The occurrence of a myocardial infarction is reported after chemotherapy containing etoposide, in a man with no risk factors for coronary heart disease.

chemotherapy containing etoposide

myocardial infarction

a man with no risk factors for coronary heart disease

after


Input: The use of beclomethasone diproprionate inhaler complicated by the development of an eosinophilic pneumonia reaction.

beclomethasone diproprionate inhaler

eosinophilic pneumonia reaction

development


Input: Nephrotic syndrome related to systemic lupus erythematosus after griseofulvin therapy.

griseofulvin

Nephrotic syndrome related to systemic lupus erythematosus

after


Input: Theoretical basal ganglia toxicologic mechanisms of methanol poisoning are reviewed, and the role of brain imaging studies will regard to diagnosis, prognosis and impact on management is discussed.

methanol

poisoning

mechanisms


Input: We report a case of drug-induced Kaposi's sarcoma (KS) on the sole of the right foot in a 71-year-old man, treated for 6 months with corticosteroid therapy (prednisolone 25 mg/day) for pericardial effusion.

a case of

a 71-year-old man

for pericardial effusion

Kaposi's sarcoma (KS)

6 months with corticosteroid therapy (prednisolone 25 mg/day)

induced


Input: We present a case of acute epinephrine toxicity resulting in acute myocardial ischemia in a young boy with combined variable immunodeficiency syndrome who developed severe allergic reaction to intravenous immunoglobulin, and was subsequently given epinephrine by mistake intravenously rather than subcutaneously.

a young boy with combined variable immunodeficiency syndrome

acute epinephrine

intravenous immunoglobulin, and was subsequently given epinephrine by mistake intravenously rather than subcutaneously

acute myocardial ischemia

severe allergic reaction

toxicity


Input: Albeit rare among Western patients, such lithium-associated thyroid dysfunctions appeared to be more likely to occur in Hong Kong Chinese.

lithium

thyroid dysfunctions

Hong Kong Chinese

associated


Input: Metaxalone has only recently been associated with serotonin syndrome.

serotonin syndrome

Metaxalone

associated


Input: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is reported in up to 18.6% of patients treated with intravenous bisphosphonates and can result in significant morbidity.

osteonecrosis of the jaw (BRONJ)

18.6% of patients

intravenous bisphosphonates

significant

related


Input: Growth and adrenal suppression in asthmatic children treated with high-dose fluticasone propionate.

Growth and adrenal suppression

asthmatic children

high-dose fluticasone propionate

in


Input: A diagnosis of infliximab-induced lupus was made and the drug treatment was withdrawn.

infliximab

lupus

induced


Input: AIMS: To identify the  human cytochrome P450 enzyme (s) involved in the in vitro metabolism of rosiglitazone, a potential oral antidiabetic agent for the treatment of type 2 diabetes-mellitus.

rosiglitazone

potential oral


Input: Neurotoxicity can occur at any time using high-dose cytosine therapy.

Neurotoxicity

high-dose cytosine

occur


Input: The possibility of phenytoin hypersensitivity reactions should be considered when patients receiving phenytoin have unusual symptoms, particularly fever, rash, and lymphadenopathy.

phenytoin hypersensitivity

fever, rash, and lymphadenopathy

phenytoin

possibility

receiving


Input: Magnesium tocolysis as the cause of urinary calculus during pregnancy.

Magnesium tocolysis

urinary calculus during pregnancy

cause


Input: Ocular ethambutol toxicity.

toxicity

Ocular ethambutol

toxicity


Input: Fatal intravascular autoimmune hemolytic anemia after fludarabine treatment for chronic lymphocytic leukemia.

Fatal intravascular autoimmune hemolytic anemia

fludarabine treatment

Fatal

after


Input: A 74-year-old patient with idiopathic Parkinson's disease was evaluated for unintended sleep episodes that occurred after long-term treatment with 400 mg/day of L-dopa.

A 74-year-old patient with idiopathic Parkinson's disease

long-term treatment with 400 mg/day of L-dopa

unintended sleep episodes

after


Input: Thrombotic thrombocytopenic purpura (TTP) developed in a patient with seropositive rheumatoid arthritis (RA) after 2 1/2 months of treatment with penicillamine.

Thrombotic thrombocytopenic purpura (TTP)

a patient with seropositive rheumatoid arthritis (RA)

2 1/2 months of treatment with penicillamine

developed


Input: Phenolphthalein-induced toxic epidermal necrolysis.

Phenolphthalein

toxic epidermal necrolysis

induced


Input: We present a case of ethylenediamine-induced delayed hypersensitivity reaction in a 46-year-old woman who received parenteral aminophylline for an acute asthma exacerbation.

ethylenediamine

delayed hypersensitivity reaction

a 46-year-old woman

induced

a 46-year-old woman

parenteral aminophylline

received


Input: Physicians should be aware of the potentially lethal side effects of dapsone.

dapsone

lethal side effects

potentially

lethal

of


Input: Acute myocardial necrosis during administration of amsacrine.

Acute myocardial necrosis

amsacrine

during


Input: Rapid identification of speech loss linked to FK506 may be important because reduction or cessation of the drug may be associated with reverse of speech loss.

speech loss

linked


Input: Fatal pulmonary fibrosis following 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy.

pulmonary fibrosis

1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy

Fatal

following


Input: The increasing prevalence of methamphetamine abuse and the severity of the associated ulcers should alert ophthalmologists to the problem of methamphetamine-related keratitis.

associated ulcers

keratitis

methamphetamine abuse

methamphetamine

severity

related


Input: MDS was diagnosed 8.4 months after beginning TMZ.

MDS

8.4 months after beginning TMZ

diagnosed


Input: Uveitis associated with rifabutin therapy: a clinical alert.

Uveitis

rifabutin therapy

associated


Input: We report a case of a patient with ciprofloxacin-induced SJS and acute onset of VBDS, and reviewed the related literature.

ciprofloxacin

SJS

acute onset of VBDS

a patient

induced


Input: This case supports the assessment that MH and diabetes are associated diseases and that cresol could possibly trigger MH.

cresol

MH

possibly

trigger


Input: Neonatal mydriasis: intravenous lidocaine adverse reaction.

Neonatal mydriasis

lidocaine

Neonatal

adverse reaction


Input: Acute renal failure in a patient treated by continuous povidone-iodine mediastinal irrigation.

Acute renal failure

a patient

continuous povidone-iodine mediastinal irrigation

in


Input: To our knowledge, this is the first case of griseofulvin-exacerbated lupus in which nephrotic syndrome has been observed.

griseofulvin

lupus

nephrotic syndrome

the first case

To our knowledge

exacerbated


Input: After reviewing the literature we suggest the CPM was a complication of lithium toxicity which affected the lateral geniculate nucleus which produced blindness.

CPM

lithium toxicity

blindness

lithium

suggest

complication


Input: A 71-year-old man, who had a history of a previous bullous drug reaction to a sulfonamide, began receiving an ophthalmic preparation that contained sulfacetamide sodium.

A 71-year-old man

sulfonamide

bullous

reaction


Input: The authors report on two patients with corneal ulcers refractory to conventional treatment while the patients were undergoing oral colchicine therapy.

two patients

oral colchicine therapy

corneal ulcers

undergoing


Input: Vancomycin-induced vasculitis.

Vancomycin

vasculitis

induced


Input: Based on our findings, it is thus concluded that cisplatin may cause C. difficile colitis.

cisplatin

C. difficile colitis

may

cause


Input: Nephrotic syndrome associated with lithium therapy.

Nephrotic syndrome

lithium therapy

associated


Input: We report 2 patients who developed polyarteritis nodosa following vaccination against hepatitis B.

2 patients

polyarteritis nodosa

vaccination against hepatitis B

developed


Input: We recommend the cautious use of ketorolac in patients with underlying illnesses where NSAID-induced ototoxicity could result in adverse otologic consequences.

ketorolac

patients with underlying illnesses

NSAID-induced ototoxicity could result in adverse otologic consequences

could

where


Input: Colitis as a manifestation of infliximab-associated disseminated cryptococcosis.

Colitis

infliximab

associated


Input: A 15-month-old girl with rhinopharyngitis was treated with a nasal solution containing the imidazoline derivative naphazoline.

A 15-month-old girl with rhinopharyngitis

a nasal solution containing the imidazoline derivative naphazoline

treated


Input: Three diabetic cases of acute dizziness due to initial administration of voglibose.

Three diabetic cases

acute dizziness

initial administration of voglibose

due


Input: Fatal cold medication intoxication in an infant.

Fatal cold medication intoxication

cold medication

infant

in


Input: Case study: a modified topical treatment regimen for sodium warfarin-induced necrotizing fasciitis.

sodium warfarin

necrotizing fasciitis

induced


Input: Marked QT prolongation and torsades de pointes secondary to acute ischemia in an elderly man taking dofetilide for atrial fibrillation: a cautionary tale.

dofetilide

an elderly man

Marked QT prolongation and torsades de pointes secondary to acute ischemia

taking


Input: Methylphenidate and dextroamphetamine-induced peripheral vasculopathy.

Methylphenidate and dextroamphetamine

peripheral vasculopathy

induced


Input: The reversal of heparin by protamine may cause severe hemodynamic deterioration, characterized by systemic hypotension, pulmonary hypertension, and bronchoconstriction.

severe hemodynamic deterioration

systemic hypotension, pulmonary hypertension, and bronchoconstriction

The reversal of heparin by protamine

may

cause


Input: OBJECTIVE: To report a case of severe apnea in an infant exposed to lamotrigine through breast-feeding.

severe apnea

an infant

exposed to lamotrigine through breast-feeding

severe

in


Input: Hemodynamic collapse following labetalol administration in preeclampsia.

Hemodynamic collapse

labetalol

following


Input: We report a case of a 35-year old female who developed new onset type II diabetes mellitus with hyperosmolar hyperglycaemic coma and acute renal failure following treatment with a SGA for a first manic episode.

35-year old female

type II diabetes mellitus with hyperosmolar hyperglycaemic coma and acute renal failure

treatment with a SGA

developed


Input: We report the occurrence of renal failure due to cholesterol crystal embolization following thrombolytic therapy with intravenous recombinant tissue-type plasminogen activator (t-PA).

thrombolytic therapy with intravenous recombinant tissue-type plasminogen activator (t-PA)

renal failure due to cholesterol crystal embolization

occurrence


Input: The asthma resolved within 24 hours following three albuterol inhalations.

three albuterol inhalations

resolved


Input: Administration of amantadine was associated with psychotic decompensations in two schizophrenic patients being maintained on concomitant neuroleptic medication.

concomitant neuroleptic medication

amantadine

psychotic decompensations

two schizophrenic patients

associated


Input: Clinicians should be aware of fasting hypoglycemia as an unusual but potentially serious complication of disopyramide therapy.

disopyramide

fasting hypoglycemia

potentially

complication


Input: To the best of our knowledge, this is the first reported patient with captopril-induced pemphigus in whom no new lesions developed after subsequent treatment with enalapril.

captopril

pemphigus

patient

induced


Input: Fortunately, a hypersensitivity reaction to one formulation of cyclosporine does not preclude use of a different formulation.

hypersensitivity reaction

one formulation of cyclosporine

to


Input: She developed a severe urticarial rash 3 weeks following initiation of therapy with Enoxaparin.

urticarial rash

Enoxaparin

severe

developed


Input: Fatal toxic epidermal necrolysis related to lamotrigine administration.

Fatal toxic epidermal necrolysis

lamotrigine administration

Fatal

related to


Input: OBJECTIVE: To document a case of serotonin syndrome (SS) associated with mirtazapine monotherapy, review the previously reported cases of SS associated with this tetracyclic antidepressant, and discuss the possible pathogenic mechanisms leading to this serious adverse drug reaction.

a case

serotonin syndrome (SS)

mirtazapine monotherapy

associated


Input: CONCLUSION: Therapy with indapamide may induce diabetes in essential hypertension patients.

diabetes

indapamide

essential hypertension patients

may

induce


Input: Placebo-controlled clinical trials of recombinant human interleukin-11 (rhIL-11, also known as oprelvekin [Neumega]) in patients with nonmyeloid malignancies have demonstrated significant efficacy in preventing postchemotherapy platelet nadirs of < or = 20,000/microL, and reducing the need for platelet transfusions while continuing chemotherapy without dose reductions.

patients with nonmyeloid malignancies

recombinant human interleukin-11 (rhIL-11, also known as oprelvekin [Neumega])

preventing


Input: A patient with rheumatoid arthritis developed an acute intrahepatic cholestasis after 100 mg of sodium aurothiomalate.

A patient with rheumatoid arthritis

acute intrahepatic cholestasis

100 mg of sodium aurothiomalate

developed


Input: We concluded that the colonic ulcer and the sigmoidovesical fistula had been caused by the administration of calcium polystyrene sulfonate and sorbitol.

calcium polystyrene sulfonate and sorbitol

colonic ulcer and the sigmoidovesical fistula

caused


Input: Rosiglitazone, a thiazolidinedione antidiabetic medication used in the treatment of Type 2 diabetes mellitus, is predominantly metabolized by the cytochrome P450 (CYP) enzyme CYP2C8.

Rosiglitazone

a thiazolidinedione antidiabetic medication

used


Input: Interstitial lung disease (ILD) related to therapy with the drug gefitinib has been well reported.

Interstitial lung disease (ILD)

therapy with the drug gefitinib

related


Input: According to the Naranjo adverse drug reaction probability scale, tigecycline was the probable cause of her acute pancreatitis.

acute pancreatitis

tigecycline

probable

cause


Input: We report a case of severe anemia, which responded well to steroid therapy, in a patient receiving IL-2 plus IFN-alpha for metastatic renal cell carcinoma.

IL-2 plus IFN-alpha

a patient

severe anemia

severe

receiving

steroid

responded


Input: The patient's movements resolved following diphenhydramine administration.

diphenhydramine

resolved


Input: The spectrum of nitrofurantoin lung injury continues to widen.

lung injury

nitrofurantoin

widen


Input: We describe a patient with a complex medication regimen who was admitted for rhabdomyolysis and accompanying acute renal failure, along with acute hepatitis, thought to be secondary to a drug interaction between atorvastatin and diltiazem.

a patient

atorvastatin

diltiazem

rhabdomyolysis and accompanying acute renal failure, along with acute hepatitis

secondary


Input: The current study investigated the visual fields and visual electrophysiology of eight patients with known vigabatrin-attributed visual field loss, three of whom were reported previously.

vigabatrin

visual field loss

eight patients

attributed


Input: Although the literature on the use of risperidone in elderly patients with dementia consists largely of uncontrolled trials, case reports, and chart reviews, it appears that this agent is effective for managing agitation in this population and does so with a low frequency of extrapyramidal symptoms (EPS).

use of risperidone

elderly patients with dementia

is


Input: Temozolomide-induced desquamative skin rash in a patient with metastatic melanoma.

Temozolomide

desquamative skin rash

a patient with metastatic melanoma

induced


Input: The calcium channel blockers are a group of drugs that have recently become available for the treatment of angina.

calcium channel blockers

treatment


Input: We report on a young adolescent with benign intracranial hypertension which we attribute to the use of minocycline for acne.

minocycline

a young adolescent

benign intracranial hypertension

attribute


Input: A 10-year-old asthmatic boy began to suffer from urticarial rash and moderately severe bronchospasm after 8 weeks' treatment with disodium cromoglycate.

A 10-year-old asthmatic boy

urticarial rash and moderately severe bronchospasm

8 weeks' treatment with disodium cromoglycate

after


Input: Panic anxiety after abrupt discontinuation of mianserin.

Panic anxiety

abrupt discontinuation of mianserin

after


Input: This case and other published evidence should alert physicians to the possibility of fatal erlotinib-induced ILD.

This case

erlotinib

ILD

possibility

induced


Input: Recent reports suggest that concomitant administration of CYP3A inhibitors with fentanyl may lead to dangerous drug interactions.

concomitant administration of CYP3A inhibitors with fentanyl

drug interactions

may

dangerous

lead


Input: Post-exposure prophylaxis of H1N1 with oseltamivir was safe, effective and well tolerated to prevent H1N1 influenza A virus infection in newly transplanted renal allograft recipient receiving triple immunosuppression without any interaction with tacrolimus level.

newly transplanted renal allograft recipient

oseltamivir

without any interaction with tacrolimus level

safe, effective and well tolerated to prevent H1N1 influenza A virus infection

prophylaxis


Input: DISCUSSION: Central nervous system (CNS) toxicity has been described with ifosfamide, with most cases reported in the pediatric population.

in the pediatric population

ifosfamide

Central nervous system (CNS) toxicity

described


Input: Despite the underlying hepatitis C, this case represents renal abnormalities consistent with IFNalpha therapy for CML.

renal abnormalities

this case

IFNalpha therapy

consistent


Input: CONCLUSION: To the best of our knowledge, this is the first time colchicine intoxication in this age group has been described in the English literature.

colchicine

colchicine intoxication

intoxication


Input: We have seen a case of terminal malignant melanoma in which clinical manifestations, indicative of anterior spinal artery syndrome, developed following the injection of 0.3 ml of 10% phenol-glycerine into the cervical subarachnoid space at the C4--C5 level for the control of severe right arm pain.

terminal malignant melanoma in which clinical manifestations, indicative of anterior spinal artery syndrome

the injection of 0.3 ml of 10% phenol-glycerine into the cervical subarachnoid space at the C4--C5 level

developed


Input: Colchicine-induced myopathy in renal failure.

Colchicine

myopathy

induced


Input: This report suggests that bleomycin lung toxicity may be reversible if treated aggressively.

bleomycin

lung toxicity

may

toxicity


Input: DISCUSSION: NMS is a rare but potentially fatal reaction associated with neuroleptic drugs.

neuroleptic drugs

NMS

fatal

associated


Input: Scleroderma in association with the use of bleomycin: a report of 3 cases.

Scleroderma

bleomycin

3 cases

association


Input: Linezolid-associated acute interstitial nephritis and drug rash with eosinophilia and systemic symptoms (DRESS) syndrome.

Linezolid

acute interstitial nephritis and drug rash with eosinophilia and systemic symptoms (DRESS) syndrome

associated


Input: A 3-year-old boy diagnosed with acute lymphoblastic leukemia received induction chemotherapy.

A 3-year-old boy diagnosed with acute lymphoblastic leukemia

induction chemotherapy

received


Input: Interferon and other immunostimulatory medications can lead to an exacerbation of this preexisting low-grade chronic inflammation that is quite similar to interferon-triggered sarcoidosis.

Interferon and other immunostimulatory medications

exacerbation of this preexisting low-grade chronic inflammation

lead


Input: Intravenous cytarabine and methotrexate appear to act synergistically to enhance the potential for central nervous system toxicity.

Intravenous cytarabine and methotrexate

central nervous system toxicity

enhance


Input: We suggest adding this side effect to the list of untoward effects of lidocaine and to the differential diagnosis of fixed dilated pupils in neonates treated with lidocaine.

lidocaine

neonates

side effect

treated


Input: CONCLUSIONS: Topical INF alpha 2-beta is a valid choice for the treatment of CIN in patients for whom surgery is not possible.

Topical INF alpha 2-beta

patients for whom surgery is not possible

a valid choice


Input: We report 3 patients who developed cutaneous vasculitis which is a rare and serious side-effect during antithyroid drug therapy.

3 patients

cutaneous vasculitis

during antithyroid drug therapy

developed


Input: Prominent eye movements during NREM sleep and REM sleep behavior disorder associated with fluoxetine treatment of depression and obsessive-compulsive disorder.

Prominent eye movements during NREM sleep and REM sleep behavior disorder

fluoxetine treatment

depression and obsessive-compulsive disorder

associated


Input: Allergic reaction to gemfibrozil manifesting as eosinophilic gastroenteritis.

gemfibrozil

eosinophilic gastroenteritis

Allergic reaction


Input: We suggest that sarcoidosis may develop in chronic hepatitis C patients during interferon alpha and/or ribavirin treatment, and diagnostic tests for this adverse effect should be performed during the follow-ups.

sarcoidosis

chronic hepatitis C patients

interferon alpha and/or ribavirin

may

develop


Input: Azole antifungals, prescribed prophylactically to avoid severe infections in immunosuppressed organ transplant recipients, can interact with drug substrates of CYP3A4.

Azole antifungals

drug substrates of CYP3A4

immunosuppressed organ transplant recipients

interact


Input: We present the case of a 5-year-old girl who developed bilateral vocal cord paralysis following preoperative peritonsillar bupivacaine infiltration.

a 5-year-old girl

bilateral vocal cord paralysis

preoperative peritonsillar bupivacaine infiltration

following


Input: One patient suffered coronary artery vasospasm, attributed to the use of topical 1:1000 epinephrine during surgery.

topical 1:1000 epinephrine during surgery

coronary artery vasospasm

One patient

attributed


Input: Trimethoprim-sulfamethoxazole-induced aseptic meningitis.

aseptic meningitis

Trimethoprim-sulfamethoxazole

induced


Input: We describe a patient with metastatic prostate cancer who developed nonoliguric renal failure during treatment with suramin.

suramin

a patient with metastatic prostate cancer

nonoliguric renal failure

during


Input: In conclusion, this case strongly suggests that gliclazide can induce acute icteric liver necro-inflammation which may be misdiagnosed clinically as acute viral hepatitis.

gliclazide

acute icteric liver necro-inflammation

this case

strongly suggests

induce


Input: After administration of Oxybutynin concomitantly with an increase in the dose of Dantrolene, she presented the clinical symptoms and laboratory finding of Carbamazepine intoxication.

she

Oxybutynin concomitantly with an increase in the dose of Dantrolene

Carbamazepine

clinical symptoms and laboratory finding of Carbamazepine intoxication

After


Input: A methotrexate overdosage was shown at 36 h after infusion associated with a severe renal failure.

methotrexate overdosage was shown at 36 h after infusion

severe renal failure

methotrexate

severe

associated


Input: Ceftriaxone-induced fixed drug eruption: first report.

Ceftriaxone

fixed drug eruption

induced


Input: We report the case of a 20-year-old female with polyarteritis nodosa (PAN) who developed bilateral sensorineural hearing loss 25 minutes after receiving 30 mg of intravenous ketoralac.

20-year-old female with polyarteritis nodosa (PAN)

bilateral sensorineural hearing loss

30 mg of intravenous ketoralac

developed


Input: We report an 82-year-old man who developed ventricular tachycardia and Torsades de Pointes (TdP) after oral administration of garenoxacin, a novel quinolone antibiotic agent that differs from the third-generation quinolones, for pneumonia.

oral administration of garenoxacin

an 82-year-old man

ventricular tachycardia and Torsades de Pointes (TdP)

after


Input: Lethargy in a newborn: lithium toxicity or lab error?

lithium

Lethargy

a newborn

toxicity


Input: Simultaneous toxicities in a child on multiple anticonvulsants.

a child

multiple anticonvulsants.

Simultaneous toxicities

on


Input: We report a 71-year male with castration-resistant metastatic prostate cancer who was treated with weekly docetaxel for 12 weeks and developed significant eye irritation and dryness during treatment.

significant eye irritation and dryness

a 71-year male with castration-resistant metastatic prostate cancer

weekly docetaxel for 12 weeks

developed


Input: In addition, a 31-year-old man with obsessive-compulsive disorder developed RBD soon after starting fluoxetine therapy, which persisted at PSG study 19 months after fluoxetine discontinuation.

a 31-year-old man with obsessive-compulsive disorder

RBD

which persisted at PSG study 19 months after fluoxetine discontinuation

starting fluoxetine therapy

developed


Input: Propafenone associated severe central nervous system and cardiovascular toxicity due to mirtazapine: a case of severe drug interaction.

Propafenone

mirtazapine

central nervous system and cardiovascular toxicity

severe

due to


Input: Neurotoxicity of intrathecal administration of amphotericin B.

Neurotoxicity

intrathecal administration of amphotericin B

of


Input: Parenteral pyridoxine, the specific antidote for INH-induced refractory seizures, should be readily available in every emergency department in the areas similarly experiencing increasing trends of TB.

INH

refractory seizures

induced


Input: DISCUSSION: Rhabdomyolysis is a clinical syndrome resulting from the destruction of skeletal muscle that may progress to renal failure Several drugs have been associated with rhabdomyolysis, including lovastatin, a hydroxymethylglutaryl-coenzyme A reductase inhibitor.

lovastatin, a hydroxymethylglutaryl-coenzyme A reductase inhibitor

Rhabdomyolysis is a clinical syndrome resulting from the destruction of skeletal muscle that may progress to renal failure

associated


Input: Thrombocytosis associated with enoxaparin: A very rare cause in newborns.

Thrombocytosis

enoxaparin

newborns

associated


Input: The spectrum of renal lesions occurring during antituberculous therapy, particularly in association with rifampin, may be wider than previously suspected.

antituberculous therapy, particularly in association with rifampin

The spectrum of renal lesions occurring

during


Input: Native arterial thrombosis, though recognized as a severe complication of thrombin injection, has not been well described in the literature.

Native arterial thrombosis

thrombin injection

severe

complication


Input: After treatment with levetiracetam, seizures recurred and intravenous loading with valproic acid was administered, but resulted in a rapid increase in international normalized ratio (INR) to 7.6.

levetiracetam

seizures

recurred

intravenous loading with valproic acid

administered


Input: Acute hepatitis with prolonged cholestasis and disappearance of interlobular bile ducts following tibolone and Hypericum perforatum (St. John's wort).

tibolone and Hypericum perforatum (St. John's wort)

Acute hepatitis with prolonged cholestasis and disappearance of interlobular bile ducts

following


Input: METHODS: Five cases of contact dermatitis due to budesonide, a nonhalogenated steroid, are described.

contact dermatitis

budesonide

Five cases

due to


Input: This sulfonamide like nephropathy should be differentiated from acetazolamide-related calcium phosphate nephrolithiasis.

calcium phosphate nephrolithiasis.

acetazolamide

related


Input: Aripiprazole was subsequently discontinued secondary to its lack of efficacy for OCD and the development of a movement disorder.

Aripiprazole

a movement disorder

development


Input: Gigantomastia induced by bucillamine.

Gigantomastia

bucillamine

induced


Input: Hypersensitivity to carboplatin has been reported in up to 44% of patients receiving this antineoplastic agent, usually occurring after several courses of treatment.

44% of patients

Hypersensitivity

carboplatin

after several courses of treatment

to


Input: CONCLUSIONS: In our reported case, a local hyperproduction of TNF-alpha from macrophages that was induced by the injected insulin could explain the dedifferentiation of the adipocytes of the subcutaneous tissue and the reversion that was induced by the local injection of dexamethasone.

injected insulin

local hyperproduction of TNF-alpha from macrophages

dedifferentiation of the adipocytes of the subcutaneous tissue

reported case

induced


Input: Both venlafaxine and trimipramine have been associated with seizures, mainly after overdose.

overdose

venlafaxine and trimipramine

seizures

associated


Input: Thirty-six patients with AL received, in a three-month period, 51 cycles of combined chemotherapy which included, in all of them, cytosine arabinoside (ARA-C); among them, along with myelosuppression, five experienced fever, infectious complications, gastrointestinal tract symptoms and severe myalgias.

fever, infectious complications, gastrointestinal tract symptoms and severe myalgias

chemotherapy

cytosine arabinoside (ARA-C)

five

experienced


Input: Infliximab-induced lupus in Crohn's disease: a case report.

Infliximab

a case

lupus

induced


Input: The infection tended to subside with the AMPH administration.

AMPH administration

infection tended

subside


Input: CONTEXT: Acute drug induced hepatitis has not been commonly associated with epidermal growth factor receptor (EGFR) inhibitors.

epidermal growth factor receptor (EGFR) inhibitors

Acute drug induced hepatitis

not

associated


Input: We report a case of fatal pulmonary toxicity in a patient with advanced non-small cell lung cancer who received erlotinib.

erlotinib

pulmonary toxicity

a patient with advanced non-small cell lung cancer

fatal

received


Input: We describe a patient with idiopathic RLS who developed augmentation after 8 months of levodopa treatment.

a patient with idiopathic RLS

augmentation

after 8 months of levodopa treatment

developed


Input: This communication describes a patient who developed Schneiderian first-rank symptoms in the course of treatment with fluvoxamine.

Schneiderian first-rank symptoms

fluvoxamine

a patient

developed


Input: In addition to the recognized arrhythmic complications, the authors emphasize myocardial necrosis as a possible further manifestation of amsacrine-related cardiotoxicity.

myocardial necrosis

cardiotoxicity

amsacrine

possible

related


Input: The authors caution that treatment with alprazolam may be complicated by the induction of mania.

treatment with alprazolam

mania

induction of


Input: The use of rituximab has been uncommonly associated with delayed pulmonary toxicity.

rituximab

delayed pulmonary toxicity

associated


Input: We believe that the acute renal failure in our patient was associated with anastrozole.

acute renal failure

patient

anastrozole

associated


Input: On the fifth day of tocolysis with magnesium sulfate, nifedipine, terbutaline and betamethasone, edema developed in both labia.

edema

in both labia

On the fifth day of tocolysis with magnesium sulfate, nifedipine, terbutaline and betamethasone

developed


Input: Two patients with extrinsic asthma and coexistent insulin-dependent diabetes mellitus sustained an anaphylactoid reaction after the intravenous administration of 50% solution of dextrose.

intravenous administration of 50% solution of dextrose

Two patients with extrinsic asthma and coexistent insulin-dependent diabetes mellitus

anaphylactoid reaction

after


Input: Cardiac arrest after esmolol administration: a review of acute beta-blocker toxicity.

esmolol

Cardiac arrest

after


Input: We suggest that nicotinic acid was the cause of his liver disease, that this case is of particular note because of the rather short period of therapy before the onset of liver injury and the severity of the hepatic failure, and that the probable increased use of nicotinic acid for serum cholesterol control makes it especially important for physicians and their patients to be alert to the signs of hepatotoxicity.

nicotinic acid

liver disease

cause


Input: METHODS: Two patients with exudative age-related macular degeneration were treated sequentially with an intravitreal injection of bevacizumab and developed signs of severe but painless infectious endophthalmitis 2 days later.

Two patients

intravitreal injection of bevacizumab

2 days later

infectious endophthalmitis

severe

developed


Input: Ibuprofen-induced meningitis: detection of intrathecal IgG synthesis and immune complexes.

Ibuprofen

meningitis

induced


Input: Tardive oculogyric crisis during treatment with clozapine: report of three cases.

Tardive oculogyric crisis

clozapine

three cases

with


Input: Myasthenia gravis during low-dose IFN-alpha therapy for chronic hepatitis C.

Myasthenia gravis

low-dose IFN-alpha therapy

during


Input: We herein report this rare case of acute onset of nephrotic syndrome during interferon-alpha retreatment.

acute onset of nephrotic syndrome

interferon-alpha

during


Input: Para-aminosalicylic acid-induced hypoglycaemia in a patient with diabetic nephropathy.

a patient with diabetic nephropathy

Para-aminosalicylic acid

hypoglycaemia

induced


Input: Ischaemia following selfadministered intra-arterial injection of methylphenidate and diamorphine.

Ischaemia

selfadministered intra-arterial injection of methylphenidate and diamorphine

following


Input: Mitomycin C-related hemolytic uremic syndrome in cancer patients.

Mitomycin C

hemolytic uremic syndrome

cancer patients

related


Input: The second had acute cystitis and was treated by sulphonamide and the third developed myopia coincident with metronidazole treatment for trichomonas vaginalis.

myopia

metronidazole treatment

the third

developed

sulphonamide

treated


Input: Acute bilateral phrenic neuropathy following treatment with adalimumab.

Acute bilateral phrenic neuropathy

adalimumab

following


Input: Hypoxemia improved during continuous tolazoline infusion, but gastrointestinal bleeding occurred.

gastrointestinal bleeding

Hypoxemia improved during continuous tolazoline infusion

occurred


Input: BACKGROUND: NVP is a non-nucleoside reverse transcriptase inhibitor used in the treatment of Human Immunodeficiency Virus (HIV) infection.

NVP

used


Input: A 62-year-old Indian with diabetic nephropathy controlled with metformin, developed miliary tuberculosis for which he was treated with rifampicin, isoniazid and ethambutol.

miliary tuberculosis

A 62-year-old Indian with diabetic nephropathy

metformin

developed

rifampicin, isoniazid and ethambutol

treated


Input: A patient with acute esophageal variceal bleeding developed fatal rhabdomyolysis during treatment with a continuous intravenous infusion of vasopressin.

continuous intravenous infusion of vasopressin

A patient with acute esophageal variceal bleeding

fatal rhabdomyolysis

fatal

during


Input: Preliminary results suggest that the higher concentrations of dextrose induce increased histamine release from blood cells, and that this phenomenon is more marked in diabetic, and particularly diabetic-allergic, individuals.

higher concentrations of dextrose

increased histamine release from blood cells

diabetic, and particularly diabetic-allergic, individuals

induce


Input: All patients beginning HMG-CoA reductase inhibitor therapy should be counseled regarding the signs and symptoms of muscle injury; particular attention should be paid to those patients who are taking medications that may interact.

All patients

HMG-CoA reductase inhibitor

the signs and symptoms of muscle injury

regarding


Input: Interferon-alpha-induced hyperthyroidism: a three-stage evolution from silent thyroiditis towards Graves' disease.

Interferon-alpha

hyperthyroidism

Graves' disease

induced


Input: Acute severe intoxication with carbamazepine is associated with seizures, coma and respiratory depression.

carbamazepine

Acute severe intoxication

associated


Input: CONCLUSION: We have introduced a case of anaphylaxis by calcitonin that suggest an IgE mediated hypersensitivity reaction.

a case

anaphylaxis

calcitonin

by


Input: PURPOSE: To describe transient structured visual hallucinations in a patient with vascular age-related macular degeneration (AMD), following an intravitreal Avastin-injection.

transient structured visual hallucinations

a patient with vascular age-related macular degeneration (AMD)

an intravitreal Avastin-injection

transient

following


Input: Bortezomib-induced paralytic ileus is a potential gastrointestinal side effect of this first-in-class anticancer proteasome inhibitor.

Bortezomib

paralytic ileus

induced


Input: Fatal gemcitabine-induced pulmonary toxicity in metastatic   gallbladder adenocarcinoma.

pulmonary toxicity

gemcitabine

induced


Input: It is suggested that the fatal stroke may have resulted from arterial spasm caused by ergotamine overdosage and possibly complicated by thrombosis.

stroke

arterial spasm

ergotamine overdosage

may

fatal

caused


Input: During the anti-tuberculous therapy, visual loss can be related to ethambutol toxicity or the tuberculosis infection itself.

visual loss

ethambutol

related


Input: Elevated International Normalized Ratio in a patient concurrently using warfarin and vismodegib.

warfarin and vismodegib

Elevated International Normalized Ratio

a patient

using


Input: Occurrence of IDDM during interferon therapy for chronic viral hepatitis.

IDDM

interferon therapy

during


Input: Pseudomembranous colitis readily occurs in at least certain population groups receiving trimethoprim-sulfamethoxazole.

Pseudomembranous colitis

certain population groups

trimethoprim-sulfamethoxazole

occurs


Input: RESULTS: Budesonide use can cause contact dermatitis.

Budesonide

contact dermatitis

cause


Input: Hypertension develops in most patients after transplantation when immunosuppression is based on cyclosporine and prednisone.

Hypertension

most patients

after transplantation

immunosuppression is based on cyclosporine and prednisone

when


Input: It was concluded that potassium loss occurred by a non-renal (intestinal) route in phosphate-induced hypokalemia.

potassium loss

hypokalemia

phosphate

induced


Input: We have described three patients with hepatitis C for whom IFN-alpha and ribavirin were prescribed and who developed two successive phases of silent thyroiditis followed by hyperthryroidism relapse due to Graves' disease.

three patients with hepatitis C

IFN-alpha and ribavirin

two successive phases of silent thyroiditis followed by hyperthryroidism relapse due to Graves' disease

developed


Input: Hepatotoxicity associated with choline magnesium trisalicylate: case report and review of salicylate-induced hepatotoxicity.

Hepatotoxicity

choline magnesium trisalicylate

case

associated


Input: CONCLUSIONS: The 3 cases presented here illustrate the development of reproductive endocrine disorders after the initiation of valproate therapy in women with epilepsy.

The 3 cases

women with epilepsy

reproductive endocrine disorders

after the initiation of valproate therapy

development


Input: A 43-year-old white man developed a shallow erosion of a psoriatic plaque after chronic administration of methotrexate.

A 43-year-old white man

shallow erosion of a psoriatic plaque

chronic administration of methotrexate

after


Input: CONCLUSIONS: SD-OCT and AO detected abnormalities that correlate topographically with visual field loss from hydroxychloroquine toxicity as demonstrated by HVF 10-2 and may be useful in the detection of subclinical abnormalities that precede symptoms or objective visual field loss.

visual field loss

hydroxychloroquine

from


Input: Leflunomide-induced toxic epidermal necrolysis in a patient with rheumatoid arthritis.

Leflunomide

toxic epidermal necrolysis

a patient with rheumatoid arthritis

induced


Input: Delayed bowel injury is an infrequently observed complication of chromic phosphate administration.

chromic phosphate administration

Delayed bowel injury

complication


Input: Therefore, amantadine was permanently discontinued and the cornea cleared again.

amantadine

cornea cleared

was


Input: CONCLUSION: We believe that risperidone is not a substitute for clozapine in treating psychosis in parkinsonian patients and should be used with caution.

risperidone

parkinsonian patients

not

treating

parkinsonian patients

clozapine

treating


Input: Spontaneous splenic infarction associated with sumatriptan use.

Spontaneous splenic infarction

sumatriptan

associated


Input: DISCUSSION: Anaphylactoid reactions have been described previously with cisplatin administration.

Anaphylactoid reactions

cisplatin

with


Input: The current report describes a man who was prescribed zonisamide for epilepsy and subsequently developed widespread skin rash, acute kidney injury, high-grade fever, eosinophilia, liver dysfunction, lymphadenopathy and an increase in antihuman herpesvirus-6 immunoglobulin G titer.

widespread skin rash, acute kidney injury, high-grade fever, eosinophilia, liver dysfunction, lymphadenopathy and an increase in antihuman herpesvirus-6 immunoglobulin G titer

a man

zonisamide for epilepsy

developed


Input: The toxicity of cadmium, zinc, and cadmium/zinc mixtures at concentrations ranging from 10000 to 10 microg/l was investigated.

toxicity

cadmium, zinc, and cadmium/zinc mixtures at concentrations ranging from 10000 to 10 microg/l

of


Input: We present a case of an elderly woman with a pre-existing history of ischaemic heart disease, who was treated with venlafaxine, and developed acute myocardial ischaemia within the first week of treatment.

venlafaxine

acute myocardial ischaemia within the first week of treatment

an elderly woman with a pre-existing history of ischaemic heart disease

developed


Input: Here, we describe a case of Vogt-Koyanagi-Harada disease occurring 4 months after the start of interferon alpha treatment, probably induced by the immunomodulatory effects of interferon.

Vogt-Koyanagi-Harada disease

4 months after the start of interferon alpha

a case

probably

occurring


Input: Capecitabine-induced headache responding to diltiazem.

headache

Capecitabine

induced


Input: Serotonin syndrome after concomitant treatment with linezolid and meperidine.

Serotonin syndrome

concomitant treatment with linezolid and meperidine

after


Input: We report on a child with fatal valproate-related hepatotoxic effects despite this supplementation.

valproate

hepatotoxic effects

a child

fatal

related


Input: Acute isoniazid neurotoxicity in an urban hospital.

isoniazid

Acute

neurotoxicity

in


Input: In vitro inhibition of hematopoiesis in a patient with systemic sclerosis treated with D-penicillamine.

a patient with systemic sclerosis

vitro inhibition of hematopoiesis

D-penicillamine

inhibition


Input: Rhabdomyolysis has been reported in patients receiving hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors when coadministered with agents that may inhibit their metabolism.

Rhabdomyolysis

hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors when coadministered with agents that may inhibit their metabolism

patients

receiving


Input: A 55-year-old woman presented an episode of acute urticaria and labial angioedema 60 minutes after ingesting 500 mg of cloxacillin for a skin abscess.

A 55-year-old woman

a skin abscess

acute urticaria and labial angioedema

ingesting 500 mg of cloxacillin

presented


Input: Acne provoked by gold seems not to have been described elsewhere.

Acne

gold

provoked


Input: Taxanes are widely used chemotherapeutic agents with the potential to induce pulmonary injury through a variety of mechanisms.

Taxanes

pulmonary injury

potential

induce


Input: PURPOSE: To report two cases of acute endophthalmitis following intravitreal bevacizumab injection.

intravitreal bevacizumab injection

two cases

acute endophthalmitis

following


Input: This is a case report of subtle, mild hypothermia in a 54-year old female patient receiving risperidone for schizophrenia.

mild hypothermia

a 54-year old female patient

risperidone

subtle

receiving


Input: Mycophenolate mofetil-induced neutropenia in liver transplantation.

Mycophenolate mofetil

neutropenia in liver transplantation

induced


Input: Replicate brain magnetic resonance imaging examinations after six weeks and 11 months of penicillamine therapy documented the development of new brain lesions during this period, while liver biopsy specimen data disclosed that excellent hepatic decoppering had occurred.

new brain lesions

six weeks and 11 months of penicillamine therapy

development

six weeks and 11 months of penicillamine therapy

excellent hepatic decoppering

occurred


Input: According to the literature, chlorambucil central nervous toxicity is found almost exclusively in childhood nephrotic syndrome.

childhood nephrotic syndrome

chlorambucil

central nervous toxicity

found


Input: Administration of lamotrigine, especially in combination with valproic acid, may lead to the development of TEN.

TEN

Administration of lamotrigine

with valproic acid

may

development


Input: Docetaxel induced Meibomian duct inflammation and blockage is the likely cause of this presentation in a patient with no history of eyelid masses in the past.

Docetaxel

Meibomian duct inflammation and blockage

a patient with no history of eyelid masses in the past

likely

induced


Input: We describe a unique case of disseminated cryptococcosis presenting as colitis that mimicked an exacerbation of Crohn's disease in a TNF-alpha inhibitor recipient.

an exacerbation of Crohn's disease

a TNF-alpha inhibitor

recipient

in


Input: Rhabdomyolysis associated with the use of intravenous vasopressin.

Rhabdomyolysis

intravenous vasopressin

associated


Input: Administration of intravenous nitroglycerin in a patient with idiopathic pulmonary hypertension resulted in an increase in pulmonary artery pressure associated with a decrease in blood flow that is best explained by an increase in pulmonary vascular resistance.

intravenous nitroglycerin

a patient with idiopathic pulmonary hypertension

increase in pulmonary artery pressure associated with a decrease in blood flow that is best explained by an increase in pulmonary vascular resistance

Administration


Input: The increased libido disappeared after fluvoxamine was discontinued.

increased libido

fluvoxamine

after


Input: Coadministration of antidepressant agents such as nefazodone, or any other drug that inhibits the CYP3A4 isoenzyme subfamily, should be anticipated to interfere with tacrolimus metabolism.

tacrolimus

Coadministration of antidepressant agents such as nefazodone, or any other drug that inhibits the CYP3A4 isoenzyme subfamily

tacrolimus metabolism

should be anticipated

interfere


Input: CONCLUSIONS: We conclude that a high dose combined with a short infusion time increases the risk of anaphylactoid reactions with the administration of intraperitoneal cisplatin.

anaphylactoid reactions

a high dose combined with a short infusion time

administration of intraperitoneal cisplatin

risk

with


Input: Human insulin-induced lipoatrophy.

Human insulin

lipoatrophy

induced


Input: Severe hepatotoxicity from phenobarbital occurred in an infant boy who had a complicated illness with chronic bilateral subdural hematomas and sepsis.

phenobarbital

Severe hepatotoxicity

an infant boy who had a complicated illness with chronic bilateral subdural hematomas and sepsis.

Severe

from


Input: Cholestatic liver disease with ductopenia (vanishing bile duct syndrome) after administration of clindamycin and trimethoprim-sulfamethoxazole.

clindamycin and trimethoprim-sulfamethoxazole

Cholestatic liver disease with ductopenia (vanishing bile duct syndrome)

after


Input: The authors suggest that in the absence of any proven benefit of itraconazole prophylaxis, and given the interaction of this drug with vincristine leading to severe and even potentially fatal toxicities, the combination use of these drugs should be avoided.

itraconazole

vincristine

severe and even potentially fatal toxicities

severe and even potentially fatal

leading


Input: The determinant role of individual pharmacogenetic profile in the occurrence of tacrolimus nephrotoxicity is presented and discussed.

tacrolimus nephrotoxicity

tacrolimus

occurrence


Input: These findings suggest that bicytopenia in this patient was caused by D-Pen and may be due to different sensitivities in the hematopoietic lineage.

D-Pen

bicytopenia

patient

caused


Input: We strongly suspect that this lethal anuria was mainly due to ifosfamide, occurring in a patient having received previous cisplatin chemotherapy and with poor kidney perfusion due to transient hypotension.

lethal anuria

ifosfamide

having received previous cisplatin chemotherapy

a patient having received previous cisplatin chemotherapy and with poor kidney perfusion due to transient hypotension

suspect

occurring


Input: Clinicians have been aware of lithium toxicity for many years and traditionally have administered thiazide diuretics for lithium-induced polyuria and nephrogenic diabetes insipidus.

thiazide diuretics

administered


Input: We report the first case of acute renal failure with hyperkalemia associated with the recently marketed direct renin inhibitor aliskiren.

acute renal failure with hyperkalemia

renin inhibitor aliskiren

associated


Input: The authors describe a patient with hemiparesis who developed the syndrome of irreversible lithium-effectuated neurotoxicity (SILENT) while being treated with lithium for a manic episode.

a patient with hemiparesis

irreversible lithium-effectuated neurotoxicity (SILENT)

lithium for a manic episode

developed


Input: over the past 3 years there have been several reports of uveitis associated with rifabutin therapy.

uveitis

rifabutin therapy

associated


Input: Propylthiouracil-induced cutaneous vasculitis.

Propylthiouracil

cutaneous vasculitis

induced


Input: It has been reported that fluoroquinolone antimicrobials prolong the corrected QT interval but rarely cause torsade de pointes.

fluoroquinolone antimicrobials

corrected QT interval but rarely cause torsade de pointes

prolong


Input: Succinylcholine-induced hyperkalemia in a patient with mucositis secondary to chemotherapy.

Succinylcholine

a patient with mucositis

hyperkalemia

induced


Input: To our knowledge, this is the first case of spontaneous remission of MTX-associated gastric LPD after discontinuation of MTX therapy.

the first case

MTX

gastric LPD

associated


Input: We describe a patient with acute myeloblastic leukemia (AML) who developed nephrotic syndrome after receiving several courses of chemotherapy, including macrophage-colony-stimulating factor (M-CSF).

a patient with acute myeloblastic leukemia (AML)

several courses of chemotherapy, including macrophage-colony-stimulating factor (M-CSF)

nephrotic syndrome

after


Input: Actinomycin D associated hepatic veno-occlusive disease--a report of 2 cases.

Actinomycin D

hepatic veno-occlusive disease

associated


Input: Our patient developed both nephrogenic diabetes insipidus and renal tubular acidosis with a temporal pattern that demonstrated a link between foscarnet therapy and these abnormalities.

foscarnet

nephrogenic diabetes insipidus and renal tubular acidosis

patient

developed


Input: We report a case of acne fulminans occurring during treatment with 13-cis-retinoic acid for cystic acne.

a case

13-cis-retinoic acid

acne fulminans

occurring


Input: Verapamil is widely used for the termination of paroxysmal supraventricular tachycardia (PSVT) with little proarrhythmic effect.

Verapamil

proarrhythmic effect

little

with


Input: Acute kidney injury caused by zonisamide-induced hypersensitivity syndrome.

zonisamide

hypersensitivity syndrome

induced


Input: Our findings suggest that hyperkalemia can develop with the use of low-dose heparin, within seven days of initiating heparin therapy, and that patients with diabetes mellitus or chronic renal insufficiency are especially predisposed to this complication.

hyperkalemia

low-dose heparin, within seven days of initiating heparin therapy

patients with diabetes mellitus or chronic renal insufficiency

develop


Input: We report a case of Zidovudine induced anaemia and bone marrow aplasia in a patient infected with HIV.

anaemia and bone marrow aplasia

Zidovudine

a patient infected with HIV

induced


Input: We present the case of an adult Crohn's disease patient with a parvovirus B19 infection and leukopenia during long-term AZA therapy.

adult Crohn's disease patient

long-term AZA therapy

a parvovirus B19 infection and leukopenia

during


Input: Pathogenesis of methotrexate-induced papular eruption in psoriasis may involve immune mechanisms other than those of methotrexate-induced cutaneous vasculitis in collagen vascular disease.

methotrexate

papular eruption in psoriasis

cutaneous vasculitis in collagen vascular disease

induced


Input: CASES: Two postmenopausal women treated with tamoxifen and progestational agents for breast carcinoma developed uterine enlargement and intermittent spotting.

Two postmenopausal women

tamoxifen and progestational

uterine enlargement and intermittent spotting

developed


Input: Tumor lysis syndrome after transcatheter arterial infusion of cisplatin and embolization therapy for liver metastases of melanoma.

Tumor lysis syndrome

transcatheter arterial infusion of cisplatin and embolization

after


Input: Oxcarbazepine-induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS).

Oxcarbazepine

Eosinophilia and Systemic Symptoms (DRESS)

induced


Input: Worsening of neurologic syndrome in patients with Wilson's disease with initial penicillamine therapy.

Worsening of neurologic syndrome

patients with Wilson's disease

penicillamine therapy

in


Input: Patient A reported right leg weakness (foot drop) during week 4 of CAP-XRT (1600 mg/m2).

Patient A

right leg weakness

week 4 of CAP-XRT (1600 mg/m2)

during


Input: A child in whom a phenobarbital hypersensitivity drug reaction developed which consisted of fever, a pruritic desquamating erythrodermic rash, alopecia, icterus, protein-losing enteropathy, myositis, and nephritis, is described.

A child

phenobarbital

hypersensitivity drug reaction

which consisted of fever, a pruritic desquamating erythrodermic rash, alopecia, icterus, protein-losing enteropathy, myositis, and nephritis

developed


Input: Detection of activated eosinophils in nasal polyps of an aspirin-induced asthma patient.

aspirin

asthma

induced


Input: We recommend that clinicians monitor patients for signs and symptoms of pancreatitis, including abdominal pain, during treatment with tigecycline.

tigecycline

pancreatitis, including abdominal pain

recommend

treatment


Input: We describe a patient who experienced a lichenoid eruption after the initiation of salsalate for relief of arthritic pain.

a patient

lichenoid eruption

the initiation of salsalate

after


Input: Concomitant administration of lithium with olanzapine may place patients at risk for NMS.

lithium

olanzapine

patients

NMS

at risk for

administration


Input: We report the case of an 87-year-old white woman with myasthenia gravis who presented with nausea, shortness of breath, azotemia, and hyperkalemia shortly after completing a course of intravenous immunoglobulin (IVIG).

nausea, shortness of breath, azotemia, and hyperkalemia

intravenous immunoglobulin

an 87-year-old white woman with myasthenia gravis

presented


Input: Linezolid should be discontinued immediately in patients experiencing these adverse effects.

adverse effects

Linezolid

patients

discontinued


Input: PURPOSE: Symptomatic visual field constriction thought to be associated with vigabatrin has been reported.

Symptomatic visual field constriction

vigabatrin

associated


Input: Clinically significant adverse events from a drug interaction between quetiapine and atazanavir-ritonavir in two patients.

two patients

interaction between quetiapine and atazanavir-ritonavir

Clinically significant

significant

adverse events


Input: OBJECTIVE: To report two cases of fixed drug eruption induced by methylphenidate.

two cases

methylphenidate

fixed drug eruption

induced


Input: Linezolid is an oxazolidinone antibacterial agent indicated for serious gram-positive infections.

Linezolid

indicated


Input: A search of the United States Food and Drug Administration's Adverse Event Reporting System identified nine cases of oxcarbazepine-associated angioedema in pediatric patients aged 16 years and younger.

oxcarbazepine

angioedema

pediatric patients aged 16 years and younger

associated


Input: Monitoring of liver function tests should be mandatory in patients receiving high doses of cyproterone acetate; the drug should be withdrawn immediately if abnormal liver function tests are found.

abnormal liver function

receiving high doses of cyproterone acetate

patients

abnormal


Input: In six cases CT scans did not return to their original state after ACTH therapy.

six cases

CT scans did not return to their original state

ACTH

after


Input: This report describes a probable case of infliximab-induced membranous nephropathy.

infliximab

membranous nephropathy

induced


Input: Thrombotic thrombocytopenic purpura during penicillamine therapy in rheumatoid arthritis.

Thrombotic thrombocytopenic purpura

penicillamine

during


Input: OBJECTIVE: The purpose of this study was to determine whether desensitization to NPH insulin, as well as standard insulin desensitization, could control allergic symptoms in a patient allergic to both NPH and regular insulin.

desensitization to NPH insulin, as well as standard insulin desensitization

a patient allergic to both NPH and regular insulin

whether

control


Input: Fulminant hepatic failure developed in a 24-year-old black woman who had been treated with propylthiouracil and propranolol for hyperthyroidism.

a 24-year-old black woman

Fulminant hepatic failure

propylthiouracil and propranolol

developed


Input: However, as the use of hepatitis B vaccination is growing, adverse side effects, including mental nerve neuropathy, should be observed with an increased frequency.

hepatitis B vaccination

mental nerve neuropathy

observed


Input: Acute coronary events following cisplatin-based chemotherapy.

Acute coronary events

cisplatin-based chemotherapy

following


Input: Capecitabine (CAP) is a pro-drug of 5-FU and peripheral neuropathy associated with CAP has not been reported.

peripheral neuropathy

CAP

not

associated


Input: PURPOSE: To report a case of angiographically documented cystoid macula edema occurring after switching a pseudophakic patient from latanoprost to bimatoprost.

a pseudophakic patient

from latanoprost to bimatoprost.

case of angiographically documented cystoid macula edema

switching


Input: The clinical picture was identical to that of chloroquine and hydroxychloroquine maculopathy.

chloroquine and hydroxychloroquine

maculopathy

identical


Input: CONCLUSION: A woman receiving enoxaparin every 12 hours developed signs and symptoms of hepatotoxicity after the second dose.

A woman

enoxaparin every 12 hours

after the second dose

signs and symptoms of hepatotoxicity

developed


Input: A case of liver damage following treatment with Danazol for fibrocystic breast disease is reported.

liver damage

Danazol

following


Input: Antacid and sucralfate-induced hypophosphatemic osteomalacia: a case report and review of the literature.

Antacid and sucralfate

hypophosphatemic osteomalacia

a case

induced


Input: We report a case of senna-induced cholestatic hepatitis which was not diagnosed at presentation.

senna

a case

cholestatic hepatitis

induced


Input: Five patients are described in whom only gentamicin sulfate appeared responsible for acute renal failure.

acute renal failure

Five patients

gentamicin sulfate

appeared

responsible


Input: However, in order to avoid neuropathic side effects, patients under thalidomide therapy should be monitored every 6 months with nerve conduction studies while taking the drug.

neuropathic side effects

patients

thalidomide therapy

under


Input: Videopolysomnographic and pharmacokinetic studies with monitoring of plasma levodopa levels demonstrated marked motor hyperactivity during augmentation, with anarchic discharges of motor unit potentials, tonic grouped discharges and flexor spasms, associated with painful dysesthesia.

levodopa

marked motor hyperactivity during augmentation, with anarchic discharges of motor unit potentials, tonic grouped discharges and flexor spasms, associated with painful dysesthesia

demonstrated


Input: Antibiotic-associated colitis (pseudomembranous colitis) developed in four patients with spinal cord injury and taking oral trimethoprim-sulfamethoxazole.

four patients with spinal cord injury

oral trimethoprim-sulfamethoxazole

Antibiotic-associated colitis (pseudomembranous colitis)

developed


Input: We report the case of a 27-year-old Indian woman who developed maculopapular rash and angioedema secondary to carbamazepine administration.

a 27-year-old Indian woman

maculopapular rash and angioedema

carbamazepine administration

developed


Input: We reviewed the literature in an attempt to characterize the pattern and predictors of TMP/SMX-induced aseptic meningitis.

TMP/SMX

aseptic meningitis

induced


Input: Mean time between initiation of gemcitabine therapy and onset of HUS was 7.4 +/- 3.5 months, or 21.9 +/- 10.9 doses of gemcitabine.

7.4 +/- 3.5 months, or 21.9 +/- 10.9 doses of gemcitabine

HUS

onset


Input: Aluminum intoxication, along with other factors, was considered to be the cause of TC development.

Aluminum intoxication

TC development

considered

cause


Input: Agranulocytosis during clozapine therapy.

clozapine therapy

Agranulocytosis

during


Input: It was highly suspected that finasteride was associated with the anterior subcapsular opacity on the lens, and the patient therefore discontinued use of finasteride.

finasteride

anterior subcapsular opacity on the lens

the patient

highly suspected

associated


Input: Life-threatening cranial dystonia following trihexyphenidyl withdrawal.

cranial dystonia

trihexyphenidyl withdrawal

Life-threatening

following


Input: The risk of cardiac decompensation in infants with supraventricular tachycardia and congestive cardiac failure should be kept in mind prior to administration of verapamil.

cardiac decompensation

verapamil

infants with supraventricular tachycardia and congestive cardiac failure

risk


Input: We describe serotonin syndrome after concomitant use of linezolid and meperidine in a 27-year-old man with acute leukemia.

serotonin syndrome

concomitant use of linezolid and meperidine

a 27-year-old man with acute leukemia

after


Input: Recent studies have shown that under experimental conditions ferrous sulfate may reduce the gastrointestinal absorption of orally administered levothyroxine sodium in patients with primary hypothyroidism.

reduce the gastrointestinal absorption of orally administered levothyroxine sodium

ferrous sulfate

orally administered levothyroxine sodium

patients with primary hypothyroidism

may

reduce


Input: We report here a case of cardiovascular and neurological depression induced by oxymetalzoline in a toddler.

oxymetalzoline

cardiovascular and neurological depression

a toddler

induced


Input: The association between heparin and priapism is often recognized; abnormal platelet aggregation could play a role in the pathogenesis of this side effect.

heparin

priapism

association


Input: Posterior leukoencephalopathy following cisplatin, bleomycin and vinblastine therapy for germ cell tumor of the ovary.

Posterior leukoencephalopathy

cisplatin, bleomycin and vinblastine therapy for germ cell tumor of the ovary

following


Input: OBJECTIVE: To report a case of cutaneous and hematologic toxicity in a patient treated with IL-2.

a patient

cutaneous and hematologic toxicity

case


Input: Flecainide is a rare cause of hypersensitivity pneumonitis, and few cases have been reported.

Flecainide

hypersensitivity pneumonitis

cause


Input: The patient developed grade 3 capecitabine-induced headache.

capecitabine

headache

induced


Input: We report a case of biopsy-proven acute tubulointerstitial nephritis associated with a second course of flurbiprofen, a nonsteroidal anti-inflammatory drug of the propionic acid class.

a second course of flurbiprofen

biopsy-proven acute tubulointerstitial nephritis

associated


Input: Although an association between exposure to bleomycin and the development of scleroderma has been suspected, few cases are reported.

bleomycin

scleroderma

few cases

suspected

development


Input: A 74-year-old man received oral administration of pilsicainide, a pure sodium channel blocker with slow recovery kinetics, to convert paroxysmal atrial fibrillation to sinus rhythm and developed loss of consciousness two days later.

A 74-year-old man

oral administration of pilsicainide

two days later

loss of consciousness

developed


Input: Aggressive endometrial carcinoma in a breast cancer patient treated with tamoxifen with normal transvaginal ultrasonography.

Aggressive endometrial carcinoma

tamoxifen

breast cancer patient

with normal transvaginal ultrasonography

treated


Input: Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints.

dapsone

the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints

include


Input: The association of venlafaxine treatment with ischaemic events could be explained by its unique pharmacological and haemodynamic properties.

ischaemic events

venlafaxine treatment

association


Input: This selective closure of the ductus arteriosus suggests that the affected twin was predisposed to hypoxia and thus was more susceptible to ductal closure in response to indomethacin exposure.

ductal closure

indomethacin exposure

susceptible

response


Input: This pattern is suggestive of renal toxicity due to tobramycin.

renal toxicity

tobramycin

suggestive

due to


Input: OBJECTIVE: To evaluate the efficacy of the administration of insulin by a jet-injector device in stopping and reversing severe human insulin-induced lipoatrophy.

severe human

lipoatrophy

insulin

induced


Input: This is a unique autopsy case of hepatocellular carcinoma closely related to diethylstilbestrol (DES) therapy for prostatic cancer.

a unique autopsy case

diethylstilbestrol (DES)

hepatocellular carcinoma

related


Input: Argatroban for heparin-induced thrombocytopenia in hepato-renal failure and CVVHD.

Argatroban

for


Input: Falling backward in two elderly patients taking bupropion.

two elderly patients

bupropion

Falling backward

taking


Input: METHODS: Three patients with apparent itraconazole-induced liver injury were studied.

itraconazole

liver injury

Three patients

induced


Input: Six patients developed peripheral neuropathy and five patients bone marrow depression, blood transfusions were given to three patients and in all five patients bone marrow function normalized after cessation of linezolid.

all five patients

cessation of linezolid

normalized

blood transfusions

cessation of linezolid

three patients

given

linezolid

Six patients

peripheral neuropathy

developed

linezolid

five patients

bone marrow depression

developed


Input: To our knowledge, four cases of interstitial pneumonitis associated with fludarabine have been reported in medical literature.

interstitial pneumonitis

fludarabine

associated


Input: Normalization of generalized retinal function and progression of maculopathy after cessation of therapy in a case of severe hydroxychloroquine retinopathy with 19 years follow-up.

Normalization of generalized retinal function and progression of maculopathy

cessation of therapy

hydroxychloroquine

a case of severe hydroxychloroquine retinopathy

severe

after


Input: Interferon-induced psychosis as a "psychiatric contraindication" to hepatitis C treatment: a review and case-based discussion.

psychosis

Interferon

induced


Input: Prolongation of the QT interval and ventricular tachyarrhymias have been described in patients on amiodarone therapy.

Prolongation of the QT interval and ventricular tachyarrhymias

patients

amiodarone therapy

described


Input: Aripiprazole, 5 mg daily, was initiated in November 2004 as an augmentation strategy for the diagnosis of OCD.

Aripiprazole

5 mg daily

augmentation


Input: Serious adverse events experienced by patients with chronic heart failure taking spironolactone.

Serious adverse events

spironolactone

patients with chronic heart failure

experienced


Input: Review of the literature relating to methicillin-induced nephropathy suggests a hypersensitivity origin for this disorder, but immunologic and ultrastructural investigation to date has failed to elucidate pathogenesis.

methicillin

nephropathy

hypersensitivity

suggests

induced


Input: ARDS has been associated with the administration of other monoclonal antibodies, such as infliximab, gemtuzumab ozogamicin, and OKT3 and is believed to be directly mediated by release of proinflammatory cytokines.

ARDS

the administration of other monoclonal antibodies, such as infliximab, gemtuzumab ozogamicin, and OKT3

associated


Input: CASE REPORT: Soon after initiation of amiodarone HCl (200 mg/day), a 76-year-old man came to us with symptoms of visual "shining," glare, color vision anomalies, and gradually decreased vision.

a 76-year-old man

symptoms of visual "shining," glare, color vision anomalies, and gradually decreased vision

amiodarone HCl

after initiation


Input: An insulin-dependent diabetic patient with nephropathy developed severe acidosis after treatment with acetazolamide for glaucoma.

severe acidosis

An insulin-dependent diabetic patient with nephropathy

acetazolamide for glaucoma

severe

developed


Input: Severe hypo-alpha-lipoproteinemia during treatment with rosiglitazone.

hypo-alpha-lipoproteinemia

rosiglitazone

Severe

during


Input: Peripheral neuropathy and cerebellar syndrome associated with amiodarone therapy.

Peripheral neuropathy and cerebellar syndrome

amiodarone

associated


Input: CONCLUSIONS: We report this case of the concomitant appearance of multiple skin cancers and nail changes associated with hydroxyurea use.

multiple skin cancers and nail changes

hydroxyurea

case

associated


Input: As this relapse coincided with development of a strong delayed-type hypersensitivity response to tuberculin and improved after treatment with the anti-inflammatory agent oxpentifylline, it was probably caused by restoration of pathogen-specific cellular immunity.

a strong delayed-type hypersensitivity response

tuberculin

development

anti-inflammatory agent oxpentifylline

improved


Input: Itraconazole-related increased vincristine neurotoxicity: case report and review of literature.

Itraconazole

increased vincristine neurotoxicity

related


Input: A 62-year-old Caucasian man with atrial fibrillation who was taking warfarin reported an episode of hematochezia; his international normalized ratio (INR) was 1.74.

A 62-year-old Caucasian man with atrial fibrillation

warfarin

hematochezia

episode


Input: Severe anaemia related to oseltamivir during treatment of chronic hepatitis C: a new drug interaction?

anaemia

oseltamivir during treatment of chronic hepatitis C

Severe

related


Input: BACKGROUND: How to best treat psychotic patients who have had past clozapine-induced agranulocytosis or granulocytopenia remains a problem.

psychotic patients

clozapine

agranulocytosis or granulocytopenia

induced


Input: Cystoid macular edema in a low-risk patient after switching from latanoprost to bimatoprost.

Cystoid macular edema

low-risk patient

switching from latanoprost to bimatoprost

in


Input: Physicians should therefore be aware of its occurrence and carefully monitor serum levels of CPK, GOT and GPT during the treatment of diabetes insipidus with clofibrate, especially in patients with associated hypothyroidism, latent or overt, which possibly favors the development of myopathy.

patients with associated hypothyroidism, latent or overt

clofibrate

myopathy.

possibly

development


Input: Flurbiprofen-associated acute tubulointerstitial nephritis.

Flurbiprofen

acute tubulointerstitial nephritis

associated


Input: CONCLUSION: We believe this to be the first reported case of rhGH-induced hypercalcemia in an HIV-infected patient.

rhGH

hypercalcemia

an HIV-infected patient

induced


Input: A case of basilar invagination which is thought to have arisen from the patient's intrauterine exposure to phenytoin is presented.

basilar invagination

phenytoin

exposure


Input: Methotrexate pneumonitis in nonsurgical treatment of ectopic pregnancy.

nonsurgical treatment

Methotrexate pneumonitis

in


Input: Two patients who were receiving Tolazoline by infusion developed duodenal ulceration and subsequent intestinal perforation.

Two patients

receiving Tolazoline by infusion

duodenal ulceration and subsequent intestinal perforation

developed


Input: We report the case of a 14-year-old female with acute promyelocytic leukemia who developed symptomatic cardiomyopathy only 4 months into treatment with a combination of daunomycin and all-trans retinoic acid (ATRA).

a 14-year-old female with acute promyelocytic leukemia

symptomatic cardiomyopathy

4 months into treatment with a combination of daunomycin and all-trans retinoic acid (ATRA)

acute

developed


Input: Hepatotoxicity seen with erlotinib, a small molecule tyrosine kinase inhibitor to EGFR, is usually transient with mild elevation of transaminases.

erlotinib

Hepatotoxicity

transient with mild elevation of transaminases

seen


Input: RESULTS: A previously healthy 42-year-old woman presented with acute-onset delirium with psychotic features as a consequence of levofloxacin therapy.

A previously healthy 42-year-old woman

acute-onset delirium with psychotic features

levofloxacin therapy

as a consequence of


Input: Although limb dyskinesia after methylphenidate is a commonly reported side effect, to the authors' knowledge this is only the second reported case to develop both orofacial and limb dyskinesia in the acute period after the first dose of methylphenidate.

the second reported case

orofacial and limb dyskinesia

methylphenidate

only the second reported case

develop


Input: Phenylpropanolamine-induced psychosis.

Phenylpropanolamine

psychosis

induced


Input: Graft versus host-like illness in a child with phenobarbital hypersensitivity.

a child

Graft versus host-like illness

hypersensitivity

phenobarbital

hypersensitivity


Input: The wide use of phenytoin during the recent tuberculosis epidemic makes it imperative to suspect this drug interaction in patients exhibiting clinical features that might be related to phenytoin toxicity.

phenytoin

phenytoin toxicity

patients

suspect

suspect


Input: We report a case of MMC-related hemolytic uremic syndrome, and discuss the etiologic parameters, clinical aspects, prognosis and treatment modalities of this severe syndrome.

MMC

hemolytic uremic syndrome

severe

related


Input: Myasthenic patients receiving ampicillin should be closely monitored for possible acute exacerbations.

ampicillin

Myasthenic patients

acute exacerbations

possible

receiving


Input: The male patient was treated with 225-mg/day clozapine and the time to the diagnosis of agranulocytosis was 6 weeks.

The male patient

225-mg/day clozapine

agranulocytosis

diagnosis


Input: Alprazolam withdrawal delirium unresponsive to diazepam: case report.

diazepam

unresponsive

to


Input: These findings support previous studies that showed that the use of aspirin during the antecedent illness may be a risk factor for the development of RS.

aspirin

RS

may

development


Input: Chloroquine-induced bilateral ptosis.

Chloroquine

bilateral ptosis

induced


Input: DISCUSSION: To our knowledge this is the first reported case of tuberculous uveitis following treatment with etanercept.

tuberculous uveitis

etanercept

with


Input: Hyponatremia is a known adverse effect of duloxetine, and it can lead to potentially life-threatening complications.

duloxetine

Hyponatremia

potentially life-threatening complications

life-threatening

adverse


Input: A 22-year-old drug-abuser injected flunitrazepam tablets dissolved in tap water into her left femoral artery and presented with clinical signs of acute ischaemia of the left leg.

A 22-year-old drug-abuser

injected flunitrazepam tablets dissolved in tap water into her left femoral artery

acute ischaemia of the left leg

presented


Input: A patient with Parkinson's disease, initially treated with bromocriptine and subsequently with cabergoline, developed progressive pleuropulmonary abnormalities during the latter therapy.

A patient with Parkinson's disease

initially treated with bromocriptine and subsequently with cabergoline

progressive pleuropulmonary abnormalities during the latter therapy

developed


Input: Although interferon gamma has been implicated in the pathogenesis of sarcoidosis, only a few cases of sarcoidosis associated with interferon alpha therapy have been reported.

interferon gamma

sarcoidosis

pathogenesis

sarcoidosis

interferon alpha

only a few cases

associated


Input: Camptocormia, a new side effect of sodium valproate.

Camptocormia

sodium valproate

of


Input: Many patients with cardiac arrhythmias require concomitant therapy with warfarin and amiodarone.

Many patients with cardiac arrhythmias

concomitant therapy with warfarin and amiodarone

require


Input: We report the case histories of two patients with histologically confirmed adenocarcinoma of the prostate, both of whom had been treated with steroidal anti-androgen therapy in the form of cyproterone acetate prior to radical or palliative pelvic irradiation, and who subsequently developed femoral head avascular necrosis.

two patients with histologically confirmed adenocarcinoma of the prostate

steroidal anti-androgen therapy in the form of cyproterone acetate prior to radical or palliative pelvic irradiation

femoral head avascular necrosis.

treated


Input: Thus, the possible in vivo effects of insulin on adipocytes were clearly observed in this case of insulin-induced lipohypertrophy.

insulin

lipohypertrophy

possible

induced


Input: After the addition of citalopram, a desmethylclomipramine plasma level increase and an 8-hydroacy-desmethylclomipramine plasma level decrease were observed.

desmethylclomipramine plasma level increase and an 8-hydroacy-desmethylclomipramine plasma level decrease

citalopram

After