Input: During her third cycle, she again received cisplatin 100 mg/m2 over 30 minutes and developed palmar pruritus, urticaria, and edema.

cisplatin 100 mg/m2 over 30 minutes

she

palmar pruritus, urticaria, and edema

developed


Input: The case of a patient with infectious mononucleosis treated with cephalexin who later showed a rash is presented and the previous literature is reviewed.

cephalexin

rash

a patient with infectious mononucleosis

showed


Input: After 1 week of nefazodone therapy the patient experienced headache, confusion, and "gray areas" in her vision, without abnormal ophthalmologic findings.

headache, confusion, and "gray areas" in her vision, without abnormal ophthalmologic findings

patient

her

After 1 week of nefazodone therapy

experienced


Input: Nitrofurantoin-induced pulmonary toxicity during pregnancy: a report of a case and review of the literature.

Nitrofurantoin

pulmonary toxicity

induced


Input: Methylphenidate-associated enuresis in attention deficit hyperactivity disorder.

Methylphenidate

enuresis

associated


Input: To our knowledge, this is the first case report that demonstrates the occurrence of fever with low-dose amifostine therapy without the manifestation of accompanying rash or hypotension.

low-dose amifostine

fever

the first case

To our knowledge

occurrence


Input: Administration of excessive insulin induced hypoglycemia within 4 to 8 hours, followed by rebound hyperglycemia.

Administration of excessive insulin

hypoglycemia

rebound hyperglycemia

induced


Input: In both cases, symptoms of autonomic instability and severe agitation started within hours of initiation of cyclobenzaprine and fully resolved within 3 days after discontinuing the proserotoninergic drugs.

symptoms of autonomic instability and severe agitation

within hours of initiation of cyclobenzaprine

severe

started


Input: Secondary leukemia in a child with neuroblastoma while on oral etoposide: what is the cause?

a child with neuroblastoma

oral etoposide

Secondary leukemia

in


Input: Atorvastatin induced multiple organ failure.

Atorvastatin

multiple organ failure

induced


Input: While serotonin syndrome has become more frequent in an overdose situation and when an interacting drug is given, the toxicity of SSIRs is less than that of most other psychiatric drugs.

serotonin syndrome

SSIRs

toxicity


Input: A 73-year-old woman with non-Hodgkin's lymphoma had two episodes of severe, bilateral, sensori-neural hearing loss after vincristine therapy.

A 73-year-old woman with non-Hodgkin's lymphoma

two episodes of severe, bilateral, sensori-neural hearing loss

vincristine therapy

severe

after


Input: Severe hemolytic uremic syndrome in an advanced ovarian cancer patient treated with carboplatin and gemcitabine.

Severe hemolytic uremic syndrome

an advanced ovarian cancer patient

carboplatin and gemcitabine

in


Input: Ulcerative proctitis in juvenile systemic lupus erythematosus after ibuprofen treatment.

Ulcerative proctitis in juvenile systemic lupus erythematosus

ibuprofen

after


Input: Acute asthma associated with sustained-release verapamil.

sustained-release verapamil

Acute asthma

Acute

associated


Input: The renal insufficiency of three patients and the timing of the seizures implicate accumulation of ofloxacin as a contributing factor.

accumulation of ofloxacin

renal insufficiency

seizures

three patients

implicate


Input: Hemolytic uremic syndrome in a patient on cis-platinum, vinblastine and bleomycin.

cis-platinum, vinblastine and bleomycin

a patient

Hemolytic uremic syndrome

in


Input: A previous review described data on 15 patients who experienced acute hemoglobinemia or hemoglobinuria following anti-D IGIV administration for ITP or secondary thrombocytopenia.

15 patients

acute hemoglobinemia or hemoglobinuria

anti-D IGIV

following


Input: Amiodarone was discontinued, and thyrotoxicosis gradually abated.

Amiodarone

thyrotoxicosis gradually abated

was discontinued


Input: De novo absence status of late onset following withdrawal of lorazepam: a case report.

De novo absence status of late onset

withdrawal of lorazepam

following


Input: Tenofovir-associated nephrotoxicity in two HIV-infected adolescent males.

Tenofovir

nephrotoxicity

two HIV-infected adolescent males

associated


Input: Reports of colonic perforation as a result of the administration of calcium polystyrene sulfonate and sorbitol are rare.

colonic perforation

calcium polystyrene sulfonate

sorbitol

result


Input: Improved awareness of and further investigation into the neurotoxic effects of ofloxacin may enhance its safe use.

ofloxacin

neurotoxic effects

of


Input: Atypical neuroleptic malignant syndrome associated with olanzapine.

olanzapine

Atypical neuroleptic malignant syndrome

associated


Input: OBJECTIVE: The authors described a case of interferon-induced psychosis as a framework to review the literature and discuss the decision to pursue antiviral treatment in psychiatrically ill patients with hepatitis C.

interferon

psychosis

psychiatrically ill patients with hepatitis C

induced


Input: We believe that methotrexate represents a relatively effective alternative to surgery in patients with early unruptured tubal pregnancy, but suggest that it be used with caution in view of possible systemic toxicity.

patients with early unruptured tubal pregnancy

methotrexate

systemic toxicity

suggest

possible

caution


Input: After intravitreal injection of triamcinolone acetonide, cataract may rapidly develop in eyes that have been intensively treated, topically and systemically, by corticosteroids for several years.

intravitreal injection of triamcinolone acetonide

cataract

may

develop


Input: Acute endophthalmitis following intravitreal bevacizumab (Avastin) injection.

Acute endophthalmitis

intravitreal bevacizumab (Avastin) injection

following


Input: We report a case of bullous eruption, one month after starting nicardipine and lercanidipine.

starting nicardipine and lercanidipine.

bullous eruption,

after


Input: Pulmonary fibrosis associated with nabumetone.

nabumetone

Pulmonary fibrosis

associated


Input: The ability of tumor necrosis factor (TNF)-alpha inhibitors to impair pivotal pro-inflammatory host defenses may facilitate the development of disseminated cryptococcosis.

disseminated cryptococcosis

tumor necrosis factor (TNF)-alpha inhibitors

may facilitate

development


Input: This was accepted as evidence for propranolol being the cause of this conduction disorder.

propranolol

conduction disorder

cause


Input: We report a third case of a 6-week-old infant with Escherichia coli sepsis who received ampicillin and other antibiotics and subsequently developed TEN.

6-week-old infant with Escherichia coli sepsis

received ampicillin and other antibiotics

TEN

developed


Input: PURPOSE: To report a case of bilateral anterior uveitis associated with ovulation induction therapy using clomiphene citrate.

case

bilateral anterior uveitis

ovulation induction therapy using clomiphene citrate

associated


Input: A 57-year-old woman presented with a 3-week history of dysphagia for solids, 6 months after starting treatment with nifedipine.

A 57-year-old woman

dysphagia for solids

nifedipine

presented


Input: Although combinations of belladonna, ergotamine, and phenobarbital have been used for medical treatment of menopausal symptoms since the 1960s, this is the first known case report of its association with anticonvulsant hypersensitivity syndrome.

combinations of belladonna, ergotamine, and phenobarbital

anticonvulsant hypersensitivity syndrome

association


Input: Rifampin can be associated with severe adverse effects such as hepatitis, acute renal failure, hemolytic anemia, and thrombocytopenia.

Rifampin

hepatitis, acute renal failure, hemolytic anemia, and thrombocytopenia

severe

associated


Input: It is believed that this is the first reported case of reversible azathioprine-induced cholestasis associated with histological evidence of bile duct injury.

azathioprine

cholestasis

induced


Input: We present a fatal case of subacute methanol toxicity with associated diffuse brain involvement, including bilateral putaminal necrosis and cerebral edema with ventricular compression.

methanol

diffuse brain involvement, including bilateral putaminal necrosis and cerebral edema with ventricular compression

fatal

associated


Input: Patients with inoperable or metastatic colorectal cancer were randomized to receive monthly FU 400 mg/m2/day plus LV 20 mg/m2/day as intravenous push daily for five days, or FU alone.

Patients with inoperable or metastatic colorectal cancer

monthly FU 400 mg/m2/day plus LV 20 mg/m2/day as intravenous push daily for five days

receive


Input: The present report suggests that clarithromycin coadministration induces increased plasma carbamazepine concentrations, which may result in carbamazepine toxicity.

clarithromycin

carbamazepine

carbamazepine

increased plasma carbamazepine concentrations

carbamazepine toxicity.

carbamazepine

may

induces


Input: In this case, interferon alpha induced polymyositis and cardiomyopathy is diagnosed in a 33-yr-old male patient with history of chronic hepatitis B.

a 33-yr-old male patient with history of chronic hepatitis B

interferon alpha

polymyositis and cardiomyopathy

induced


Input: To describe the potential for interaction between opioids and serotonergic antidepressants leading to the development of serotonin syndrome (SS), mechanism of the interaction, and the spectrum of SS in elderly residents of a long-term care facility.

opioids

serotonergic antidepressants

serotonin syndrome

elderly residents

leading


Input: Erythema multiforme bullosum due to rifampicin.

Erythema multiforme bullosum

rifampicin

due


Input: We describe a patient with acute leukemia who developed Horner's syndrome and a severe demyelinating peripheral neuropathy leading to death after receiving high-dose cytosine arabinoside.

high-dose cytosine arabinoside.

Horner's syndrome and a severe demyelinating peripheral neuropathy leading to death

a patient with acute leukemia

acute

developed


Input: This profile should trigger a "red flag" as to the possibility of phenobarbital behavioral side effects or exacerbation of preexisting maladaptive behaviors.

phenobarbital

behavioral side effects or exacerbation of preexisting maladaptive behaviors

possibility

trigger


Input: Retinal abnormalities, including retinal hemorrhage and "cotton-wool" spots, often occur within the first 8 weeks in the course of interferon therapy in patients with chronic hepatitis C.

Retinal abnormalities, including retinal hemorrhage and "cotton-wool" spots

interferon

patients with chronic hepatitis C

occur


Input: Rapamycin/sirolimus-induced pneumonitis has been described previously in renal transplant recipients, and this report describes a stable heart-lung transplant recipient who developed a pulmonary infiltrate that reversed after ceasing SR therapy.

Rapamycin/sirolimus

pneumonitis

induced


Input: IFNalpha-induced recurrence of Graves' disease ten years after thyroidectomy in chronic viral hepatitis C.

recurrence of Graves' disease

IFNalpha

ten years after thyroidectomy

induced


Input: Risperidone withdrawal-related respiratory dyskinesia: a case diagnosed by spirography and fibroscopy.

Risperidone

respiratory dyskinesia

related


Input: Paralytic ileus in patients undergoing bortezomib treatment has been reported, although a definite attribution to bortezomib administration has not been established.

Paralytic ileus

patients

bortezomib treatment

reported


Input: Severe serotonin syndrome induced by mirtazapine monotherapy.

serotonin syndrome

mirtazapine monotherapy

Severe

induced by


Input: Three days after starting fluconazole, she developed polyuria and polydipsia and was found to have severe hyperglycemia, which led to the diagnosis of Cushing syndrome.

Three days after starting fluconazole

polyuria and polydipsia and was found to have severe hyperglycemia, which led to the diagnosis of Cushing syndrome

severe

developed


Input: Postoperative hypocalcemic tetany caused by fleet phospho-soda preparation in a patient taking alendronate sodium: report of a case.

hypocalcemic tetany

fleet phospho-soda

alendronate sodium

patient

caused


Input: Observations in our patient suggest that the leukoencephalopathy that developed in previously reported patients who received 5-fluorouracil and levamisole may have been caused at least partly by levamisole.

leukoencephalopathy

patients

levamisole

may

caused


Input: We describe the clinical response, as determined by increases in total Hb and decreased transfusion needs, in five patients with thalassemia intermedia treated with HU alone or in combination with SPB.

in five patients with thalassemia intermedia

HU alone or in combination with SPB

increases in total Hb and decreased transfusion needs

treated


Input: According to the Naranjo et al. adverse-reaction probability scale, enoxaparin was the probable cause of hepatotoxicity in this patient.

enoxaparin

hepatotoxicity

this patient

probable

cause


Input: This is the first reported case of hepatolithiasis during octreotide therapy.

hepatolithiasis

octreotide

during


Input: Treatment of amiodarone-induced thyrotoxicosis (AIT) with thionamide, lithium or radioactive iodine is ineffective.

amiodarone

thyrotoxicosis (AIT)

induced

thionamide, lithium or radioactive iodine

ineffective

Treatment


Input: Six patients with no previous signs or symptoms suggestive of coronary artery disease developed acute coronary ischemia/infarction shortly after cis-diamine-dichloroplatinum II (cisplatin) -based chemotherapy.

cis-diamine-dichloroplatinum II (cisplatin) -based chemotherapy

Six patients with no previous signs or symptoms suggestive of coronary artery disease

acute coronary ischemia/infarction

developed


Input: RESULTS: Replacing valproate with lamotrigine resulted in a decrease in serum testosterone concentrations in all 3 women.

Replacing valproate with lamotrigine

a decrease in serum testosterone concentrations

all 3 women

resulted


Input: A 65-year-old woman, in the intensive care unit because of septic shock and acute renal failure, had a small-bowel obstruction due to Amphojel concretions.

A 65-year-old woman, in the intensive care unit because of septic shock and acute renal failure

small-bowel obstruction

concretions

Amphojel

due


Input: After the first oral dose of propranolol, syncope developed together with atrioventricular block.

oral dose of propranolol

syncope

atrioventricular block

developed


Input: Sorafenib induced tumor lysis syndrome in an advanced hepatocellular carcinoma patient.

Sorafenib

an advanced hepatocellular carcinoma patient

tumor lysis syndrome

induced


Input: The symptoms did not recur during the 36 months of itraconazole treatment after discharge, and it was concluded that ITCZ was effective for A. flavus hypertrophic pachymeningitis.

The symptoms did not recur

the 36 months of itraconazole treatment after discharge

effective


Input: A prospective randomized clinical trial was implemented to assess whether the concomitant or the sequential addition of tamoxifen to chemotherapy provides improved clinical benefit in the adjuvant treatment of breast cancer in postmenopausal patients.

the concomitant or the sequential addition of tamoxifen to chemotherapy

postmenopausal patients

improved clinical benefit in the adjuvant treatment

assess

provides


Input: Increased libido in a woman treated with fluvoxamine: a case report.

Increased libido

a woman

fluvoxamine

in


Input: In the following case report, a patient developed acute interstitial nephritis with renal failure and exfoliative dermatitis following ampicillin therapy.

patient

acute interstitial nephritis with renal failure and exfoliative dermatitis

ampicillin therapy

acute

developed


Input: Severe symptoms associated with serotonin toxicity were shown to be uncommon in patients receiving linezolid and selected serotonin reuptake inhibitors.

linezolid and selected serotonin reuptake inhibitors

patients

Severe symptoms associated with serotonin toxicity

Severe

uncommon

receiving


Input: We describe the side effects of 5-FU in a colon cancer patient who suffered severe mucositis, desquamating dermatitis, prolonged myelosuppression, and neurologic toxicity that required admission to the intensive care unit.

side effects

colon cancer patient who suffered severe mucositis, desquamating dermatitis, prolonged myelosuppression, and neurologic toxicity that required admission to the intensive care unit

of


Input: There have been many reports of probable lithium-induced organic brain syndromes occurring when serum lithium levels are within or close to the therapeutic range.

lithium

when serum lithium levels are within or close to the therapeutic range

organic brain syndromes

probable

induced


Input: The patient was enrolled in a weight-loss clinic, and his diabetes medications were adjusted.Subsequently, olanzapine was discontinued because of weight gain and uncontrolled diabetes.

patient

olanzapine was discontinued

weight gain and uncontrolled diabetes

because


Input: While most physicians are aware of heparin-induced thrombocytopenia and skin necrosis, the association of heparin and hyperkalemia is less well recognized.

heparin

thrombocytopenia and skin necrosis

induced


Input: Gefitinib (IRESSA, ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, has been approved in several countries for the treatment of advanced non-small-cell lung cancer.

Gefitinib

treatment


Input: The case of a 4-year-old girl with valproate-induced stupor and electroencephalographic pattern of increased fast activity is reported.

valproate

stupor and electroencephalographic pattern of increased fast activity

a 4-year-old girl

induced


Input: Prior to surgery, levodopa induced dyskinesia had improved (< or = 50%) under treatment with amantadine (400 mg/day, po) in all three patients.

treatment with amantadine (400 mg/day, po)

all three patients

levodopa induced dyskinesia

improved


Input: Foscarnet-induced severe hypomagnesemia and other electrolyte disorders.

Foscarnet

hypomagnesemia and other electrolyte disorders

severe

induced


Input: A case is reported of a child with fatal pulmonary fibrosis following BCNU therapy.

child with fatal pulmonary fibrosis

fatal pulmonary fibrosis

BCNU therapy

fatal

following


Input: A 64-year-old man with schizophrenia developed myoclonic jerks when given higher doses of quetiapine.

A 64-year-old man with schizophrenia

myoclonic jerks

higher doses of quetiapine

developed


Input: The etiology of neurotoxicity in our two patients remains unclear; however, as CAP is rapidly metabolized to 5-FU in patients with normal liver function, it is likely that 5-FU or its active metabolites (fluoro-beta-alanine) were contributing factors.

two patients

5-FU or its active metabolites (fluoro-beta-alanine)

neurotoxicity

it is likely

contributing


Input: CONCLUSIONS: Amantadine can cause reversible corneal edema but can irreversibly reduce the density of endothelial cells.

Amantadine

reversible corneal edema

irreversibly

cause


Input: After gastric-outlet obstruction was recognized in several infants who received prostaglandin E1, we studied the association between the drug and this complication.

several infants

prostaglandin E1

gastric-outlet obstruction

received


Input: A wide variety of adverse central nervous system effects have been reported in association with propafenone; dizziness is the most common.

propafenone

adverse central nervous system effects

dizziness

most common

association


Input: Iatrogenic Cushing syndrome has been reported in patients with CF treated concomitantly, and for extended duration, with inhaled corticosteroids and CYP3A4 inhibitors.

inhaled corticosteroids and CYP3A4 inhibitors

Iatrogenic Cushing syndrome

patients with CF

reported


Input: Red blood cell anemia in a patient with pemphigus vulgaris induced by the use of mycophenolate mofetil and prednisone.

Red blood cell anemia

a patient with pemphigus vulgaris

mycophenolate mofetil and prednisone

induced


Input: Induction of systemic lupus erythematosus by interferon-gamma in a patient with rheumatoid arthritis.

interferon-gamma

systemic lupus erythematosus

a patient with rheumatoid arthritis

by


Input: In this case, unlike those previously reported, hyponatremia recurred 5 months after switching from citalopram to mirtazapine, which is believed to be a safe antidepressant.

switching from citalopram to mirtazapine

hyponatremia

after


Input: This report describes a case of acute compromise of renal function associated with hypotension in a 7-year-old boy treated with the ACE inhibitor lisinopril and the ARB losartan.

acute compromise of renal function

hypotension

a 7-year-old boy

ACE inhibitor lisinopril and the ARB losartan

associated


Input: We report a male patient with advanced AIDS who developed hypercalcemia 2 weeks after institution of rhGH therapy.

a male patient with advanced AIDS

hypercalcemia

2 weeks after institution of rhGH therapy

developed


Input: RESULTS: Both patients experienced a previously unreported side effect--falling backward--associated with bupropion use.

bupropion

Both patients

falling backward

associated


Input: A second episode of jaundice followed the intravaginal administration of a mixture of furazolidone and nifuroxime.

jaundice

intravaginal administration of a mixture of furazolidone and nifuroxime

followed


Input: Clinicians should be aware that an erythematous and exfoliative rash may be induced by temozolomide, and be familiar with the pharmacologic and supportive measures necessary for its treatment.

an erythematous and exfoliative rash

temozolomide

may

induced


Input: Captopril-induced bone marrow suppression in two cardiac patients with trisomy 21.

Captopril

bone marrow suppression

two cardiac patients with trisomy 21

induced


Input: A 65-year-old woman with angina pectoris presented with syncope after sublingual ingestion of isosorbide dinitrate (5 mg).

sublingual ingestion of isosorbide dinitrate (5 mg)

syncope

A 65-year-old woman with angina pectoris

presented


Input: The authors present a case study of a mentally healthy man who repeatedly experienced short-lived, obsessional-like suicidal ideas and images after ingestion of the anti-fungal drug ketoconazole.

a mentally healthy man

short-lived, obsessional-like suicidal ideas and images

ingestion of the anti-fungal drug ketoconazole

experienced


Input: Flaccid quadriparesis was noted after discontinuation of vecuronium.

Flaccid quadriparesis

vecuronium

noted


Input: AIMS: The aim of this study was to report on the effectiveness and tumor side effects of topical interferon (INF) alpha 2-beta in a case of conjunctiva-cornea intraepithelial neoplasia (CIN) of a patient that rejected any surgical procedure.

conjunctiva-cornea intraepithelial neoplasia (CIN) of a patient that rejected any surgical procedure

topical interferon (INF) alpha 2-beta

tumor side effects

side effects


Input: Herein is reported an unusual case of coexistent warfarin-induced skin necrosis and heparin-induced thrombocytopenia following mitral valve replacement for thromboembolic phenomena associated with marantic endocarditis and bronchial adenocarcinoma.

warfarin

skin necrosis

induced

heparin

thrombocytopenia

induced


Input: We present a case of severe unilateral posterior scleritis associated with zoledronic acid administration that was recognized and treated in a timely manner.

severe unilateral posterior scleritis

zoledronic acid

associated


Input: The patient's other comorbidities and medications have not been suggested as possible interactions with sertraline that can cause rhabdomyolysis.

sertraline

rhabdomyolysis

not

possible

cause


Input: L-asparaginase-provoked seizures as singular expression of central nervous toxicity.

seizures as singular expression of central nervous toxicity

L-asparaginase

provoked


Input: Acute non-lymphocytic leukemia in patients with ovarian carcinoma following long-term treatment with Treosulfan (= dihydroxybusulfan).

Acute non-lymphocytic leukemia

patients with ovarian carcinoma

long-term treatment with Treosulfan (= dihydroxybusulfan)

following


Input: Children treated with thalidomide should undergo regular neurophysiologic studies in order to detect presymptomatic or progressive peripheral neuropathy.

Children

thalidomide

presymptomatic or progressive peripheral neuropathy

detect


Input: Nevirapine is a non-nucleoside reverse transcriptase inhibitor widely used in combination with other antiretroviral agents for the treatment of HIV infection.

Nevirapine is a non-nucleoside reverse transcriptase inhibitor widely used in combination with other antiretroviral agents

treatment


Input: The case is presented of a 72-year-old man with hormone-refractory prostate cancer and weekly administration of 30 mg/m2 docetaxel who developed subacute interstitial pneumonitis-related pulmonary fibrosis after seven doses and died despite mechanical ventilation and high-dose corticosteroid treatment.

weekly administration of 30 mg/m2 docetaxel

seven doses

despite mechanical ventilation and high-dose corticosteroid treatment

subacute interstitial pneumonitis-related pulmonary fibrosis

and died

a 72-year-old man with hormone-refractory prostate cancer

died

developed


Input: In this case, it was suspected that a combination of cigarette smoking, pulmonary fibrosis, and low-dose methotrexate therapy might have promoted the development of lung cancer.

low-dose methotrexate therapy

the development of lung cancer

pulmonary fibrosis

promoted


Input: Rapid onset of iatrogenic adrenal insufficiency in a patient with cystic fibrosis-related liver disease treated with inhaled corticosteroids and a moderate CYP3A4 inhibitor.

iatrogenic adrenal insufficiency

inhaled corticosteroids and a moderate CYP3A4 inhibitor

a patient with cystic fibrosis-related liver disease

onset


Input: Heparin-associated thrombocytopenia and thrombosis is a severe complication of systemic heparin therapy.

Heparin

thrombocytopenia and thrombosis

associated


Input: The polycystic changes disappeared from the ovaries in 2 of the women after valproate therapy was discontinued, and the 2 women who had gained weight and developed amenorrhea while being treated with valproate lost weight and resumed menstruating after the change in medication.

polycystic changes disappeared from the ovaries

lost weight and resumed menstruating

2 of the women

after valproate therapy was discontinued

disappeared

2 women

gained weight and developed amenorrhea

valproate

while


Input: The cause of his bleeding was a severe thrombocytopoaenia, induced by chronic ingestion of quinine.

chronic ingestion of quinine

thrombocytopoaenia

severe

induced


Input: The concomitant use of antidepressant drugs associated with lithium as a co-adjuvant seems to increase the risk of this adverse reaction.

concomitant use of antidepressant drugs associated with lithium as a co-adjuvant

adverse reaction

increase


Input: Peripheral nervous system disturbances caused by cytosine arabinoside have rarely been reported.

Peripheral nervous system disturbances

cytosine arabinoside

caused


Input: We report an unusually short lived and asymptomatic episode of severe cisplatin-induced renal tubular salt wasting in a fit 41-year-old patient with malignant teratoma.

a fit 41-year-old patient with malignant teratoma

cisplatin

renal tubular salt wasting

induced


Input: This case suggests that BH-AC, a derivative of cytosine arabinoside (1-beta-D-arabinofuranosylcytosine) could be a cause of reversible encephalopathy syndrome.

BH-AC, a derivative of cytosine arabinoside (1-beta-D-arabinofuranosylcytosine)

reversible encephalopathy syndrome

This case

could be

cause


Input: She was administered metoclopramide because of nausea and, within 2 hours, developed agitation, dysarthria, diaphoresis, and a movement disorder.

metoclopramide

agitation, dysarthria, diaphoresis, and a movement disorder

developed


Input: This article describes two cases of aplastic anemia, at least one of which was almost certainly induced by the use of methazolamide, and one case of agranulocytosis related to the use of methazolamide.

two cases

aplastic anemia

methazolamide

almost certainly

induced

agranulocytosis

methazolamide

related


Input: Amprenavir is a human immunodeficiency virus-1 (HIV-1) protease inhibitor intended to be used to treat HIV-infected children.

Amprenavir

children

treat


Input: Methotrexate-induced papular eruption following treatment of psoriasis has not been previously reported.

Methotrexate

papular eruption

induced


Input: On day 7 of linezolid treatment, the patient developed severe pruritus, macular rash, facial edema, eosinophilia, marked increase in serum creatinine level, and mild hepatitis.

linezolid

the patient

pruritus, macular rash, facial edema, eosinophilia, marked increase in serum creatinine level

hepatitis

severe

mild

developed


Input: We report a fatal case of acute interstitial pneumonitis in a patient treated with carmustine (BCNU) for a brain tumor.

acute interstitial pneumonitis

a patient

for a brain tumor

carmustine (BCNU)

fatal

treated with


Input: The three reported cases demonstrate that troglitazone is an idiosyncratic hepatotoxin that can lead to irreversible liver injury.

three reported cases

irreversible liver injury

troglitazone

irreversible

lead


Input: High-grade atrioventricular block during dipyridamole stress testing.

dipyridamole stress testing

High-grade atrioventricular block

during


Input: We describe a case of intraoperative gelatine-induced anaphylaxis whose diagnosis was delayed as the use of gelatine during surgical procedures was omitted for two times in patient's medical records.

intraoperative gelatine

anaphylaxis

induced


Input: The case of a 29-year-old man suffering from falciparum malaria disease who got a reversible hearing loss from quinine therapy is presented.

a 29-year-old man suffering from falciparum malaria disease

reversible hearing loss

quinine

reversible

got


Input: The cases of two asthmatic patients who became hypokalemic after inhalation of normal doses of albuterol are presented.

two asthmatic patients

hypokalemic

inhalation of normal doses of albutero

after


Input: This article presents a case of an atypical localized cutaneous eruption with an unusual course and protracted resolution time associated with sorafenib therapy.

sorafenib therapy

an atypical localized cutaneous eruption with an unusual course and protracted resolution time

associated with


Input: METHOD: We describe two patients who presented with diabetic ketoacidosis after treatment with quetiapine and risperidone, respectively.

two patients

quetiapine and risperidone

diabetic ketoacidosis

presented


Input: We suspect that nefazodone inhibits metabolism of tacrolimus.

nefazodone

metabolism of tacrolimus

suspect

inhibits


Input: Our review of 194 RA patients and 38 PsA patients receiving MTX has identified four RA patients and one PsA patient with MTX-induced pneumonitis, giving a prevalence of 2.1% and 0.03%, respectively.

MTX

pneumonitis

194 RA patients and 38 PsA patients receiving MTX has identified four RA patients and one PsA patient

induced


Input: A case report of fatal dapsone-induced agranulocytosis in an Indian mid-borderline leprosy patient.

dapsone

agranulocytosis

an Indian mid-borderline leprosy patient

fatal

induced


Input: Autoimmune thyroid disease is a common side-effect of interferon-alpha (IFN-alpha) treatment of viral hepatitis C.

Autoimmune thyroid disease

interferon-alpha (IFN-alpha)

side-effect


Input: The side effects of MMF, such as bone marrow toxicity, have been reported.

MMF

bone marrow toxicity

reported


Input: He developed a late secondary infection in some sites treated with imiquimod.

late secondary infection

imiquimod

He

developed


Input: We report the case of a 51-year-old man in whom IFN-alpha treatment was followed by recurrence of Graves' disease 10 years after thyroidectomy was performed and the patient was declared cured.

a 51-year-old man

IFN-alpha treatment

10 years after thyroidectomy

recurrence of Graves' disease

followed


Input: We report 2 cases of maculopapular eruption and fever in patients infected with human immunodeficiency virus (HIV) on the 2nd day of first administration of ritonavir, a protease inhibitor.

ritonavir

maculopapular eruption and fever

patients

infected


Input: We report the case of a woman who developed photo-onycholysis on multiple nails after uptake of olanzapine.

a woman

photo-onycholysis on multiple nails

uptake of olanzapine

developed


Input: Cimetidine is a rare cause of drug-induced fever.

Cimetidine

fever

cause


Input: Reversible methotrexate-associated lymphoproliferative disorder resembling advanced gastric cancer in a patient with rheumatoid arthritis.

methotrexate

lymphoproliferative disorder

a patient with rheumatoid arthritis

associated


Input: The field defects and some electrophysiological abnormalities persist when vigabatrin therapy is withdrawn.

field defects and some electrophysiological abnormalities persist

vigabatrin therapy is withdrawn

persist


Input: A possible case of carbamazepine induced pancreatitis.

carbamazepine

pancreatitis

A possible case

possible

induced


Input: Subsequent to the first dose of mirtazapine the patient experienced seizures, bradycardia and prolonged QRS as well as QTc intervals on EKG.

mirtazapine

the patient

seizures, bradycardia and prolonged QRS as well as QTc intervals on EKG

Subsequent


Input: Stuttering priapism complicating warfarin therapy in a patient with protein C deficiency.

a patient with protein C deficiency

Stuttering priapism

warfarin

in


Input: She had been on a combined treatment of steroid and lobenzarit disodium for the first 3 years, and then continued with a combined treatment of steroid and bucillamine for the following years until she was found to have pulmonary tuberculosis, at which time the steroid was suspended 10 months before she visited the authors' clinic.

pulmonary tuberculosis

steroid and lobenzarit disodium for the first 3 years, and then continued with a combined treatment of steroid and bucillamine for the following years

treatment


Input: We describe a rare case of severe drug-drug interaction between propafenone and mirtazapine leading to propafenone toxicity.

a rare case

propafenone and mirtazapine

propafenone toxicity

severe

leading


Input: Because the combination of bleomycin and vinca alkaloids is commonly used for the treatment of AIDS-related Kaposi's sarcoma, clinicians should be aware of the risk of provoking acral necrosis in patients who develop Raynaud's phenomenon under chemotherapy.

acral necrosis

Raynaud's phenomenon

bleomycin

vinca alkaloids

provoking


Input: The psychotic behavior resolved completely soon after the discontinuation of levetiracetam.

discontinuation of levetiracetam

resolved


Input: Male volunteers ( n=12) participated in a randomised, two-period, crossover trial evaluating the effect of multiple doses of 600 mg rifampicin once daily for 7 days on repaglinide metabolism.

Male volunteers ( n=12)

multiple doses of 600 mg rifampicin once daily for 7 days

repaglinide metabolism

on


Input: This report suggests that anemia can occur due to MMF, in particular when it is given with prednisone, a side effect well documented in the transplantation literature when the triple combination of MMF, cyclosporine and prednisone is used.

anemia

MMF

prednisone

can

due


Input: Warfarin was initiated for deep vein thrombosis prophylaxis due to the patient's inability to ambulate.

patient's inability to ambulate

Warfarin was initiated for deep vein thrombosis

prophylaxis


Input: We report a case with chronic hepatitis C (CHC) who developed sarcoidosis after the treatment by interferon alpha and ribavirin.

sarcoidosis

treatment by interferon alpha and ribavirin

developed


Input: The relation between tacrolimus treatment and staining was suggested by the appearance of pigmentation during topical tacrolimus treatment and its clinical disappearance when treatment was stopped.

topical tacrolimus

appearance of pigmentation

during


Input: Though hypotension, dry mouth, and constipation are well-documented possible adverse effects, the possibility of clonidine-induced bradycardia is less well recognized and is rare.

clonidine

bradycardia

possibility

induced


Input: Several hypersensitivity reactions to cloxacillin have been reported, although IgE-mediated allergic reactions to the drug are rare and there is little information about possible tolerance to other semisynthetic penicillins or cephalosporins in patients with cloxacillin allergy.

hypersensitivity

cloxacillin

reactions to


Input: Brugada type electrocardiographic changes induced by concomitant use of lithium and propafenone in patient with Wolff-Parkinson-White syndrome.

Brugada type electrocardiographic changes

concomitant use of lithium and propafenone

patient with Wolff-Parkinson-White syndrome

induced


Input: Docetaxel-induced Meibomian duct inflammation and blockage leading to chalazion formation.

Meibomian duct inflammation and blockage leading to chalazion formation

Docetaxel

induced


Input: Allergic side effects of AZA are rare, and reported allergic skin eruptions from AZA are very limited in Japan.

allergic skin eruptions

AZA

from


Input: Quetiapine and obsessive-compulsive symptoms (OCS): case report and review of atypical antipsychotic-induced OCS.

obsessive-compulsive symptoms (OCS)

OCS

antipsychotic

induced


Input: Outcome of pregnancy in women treated with all-trans retinoic acid; a case report and review of literature.

all-trans retinoic acid

pregnancy in women

treated


Input: The potential development of SJS/TEN, a severe life-threatening illness, emphasizes the need for judicious use of TMP-Sx and close monitoring and follow-up for patients who were given TMP-Sx for SSTIs.

SJS/TEN, a severe life-threatening illness

patients

TMP-Sx

development


Input: A case history of a 15-year-old boy who developed incapacitating tardive dyskinesia that resolved during treatment with deanol is presented.

a 15-year-old boy

incapacitating tardive dyskinesia

deanol

resolved


Input: Drug-induced mammary hyperplasias have been reported as rare complications of D-penicillamine and Neothetazone.

mammary hyperplasias

Drug

D-penicillamine and Neothetazone

induced


Input: The purpose of this report is to document a new case of in utero CP exposure with multiple congenital anomalies and to establish an apparent CP embryopathy phenotype.

CP

multiple congenital anomalies

CP embryopathy

exposure


Input: AIM: The aim of this article is to present the clinical characteristics and management of an oral adverse effect stemming from the use of the antiretroviral medication Nevirapine (NVP).

adverse effect

antiretroviral medication Nevirapine (NVP)

from


Input: A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.

trimethoprim (TMP)-sulfamethoxazole (SMX)

fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia

A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia

receiving


Input: Treatment with infliximab is known to produce an increase of autoantibodies (antinuclear antibodies, anti-double-stranded DNA), but not clinical disease.

Treatment with infliximab

increase of autoantibodies (antinuclear antibodies, anti-double-stranded DNA), but not clinical disease

produce


Input: Serotonin syndrome, which occurs as a result of enhanced serotonin concentration in the central nervous system, is a well-known adverse effect of serotonin-active medications.

Serotonin syndrome,

serotonin-active medications

occurs


Input: Despite the risk of needle-track seeding, PEI remains useful in the treatment of HCC.

PEI

risk

remains


Input: Trimethoprim-sulfamethoxazole-induced hepatotoxicity in a pediatric patient.

a pediatric patient

Trimethoprim-sulfamethoxazole

hepatotoxicity

induced


Input: Prolonged responses were achieved with low doses of HU (3-10 mg/kg/day) and higher doses were associated with mild reversible hematologic or hepatic toxicity and no further increases in Hb.

HU (3-10 mg/kg/day) and higher doses

mild reversible hematologic or hepatic toxicity and no further increases in Hb

associated

low doses of HU

Prolonged responses

achieved


Input: Imidazoline intoxication in children.

children

Imidazoline

Imidazoline intoxication

intoxication


Input: Concomitant administration of cytarabine might have affected his liver function and there might have been interaction between the drugs.

cytarabine

liver function

might

affected


Input: The probability of developing acute leukemia in this study was not significantly correlated to the total cumulative dosage of Treosulfan.

the total cumulative dosage of Treosulfan

acute leukemia

not

developing


Input: Intraventricular vancomycin-induced cerebrospinal fluid eosinophilia: report of two patients.

Intraventricular vancomycin

cerebrospinal fluid eosinophilia

two patients.

induced


Input: This case supports the view that in gold-induced pneumonitis a prolonged treatment with corticosteroids may be necessary, as lung function continued to improve.

a prolonged treatment with corticosteroids

as


Input: Massive plasmocytosis due to methimazole-induced bone marrow toxicity.

bone marrow toxicity

Massive plasmocytosis

methimazole

induced


Input: RESULTS: After 4- to 14-month period of therapy with the combination of indapamide (2.5 mg/day) and fosinopril (10 mg/day) in three patients and 6-month period of monotherapy with indapamide (2.5 mg/day) in one patient, glucose levels of all patients increased and achieve criteria of diabetes diagnoses.

6-month period of monotherapy with indapamide (2.5 mg/day)

one patient

glucose levels of all patients increased and achieve criteria of diabetes diagnoses

achieve

glucose levels of all patients increased and achieve criteria of diabetes diagnoses

After 4- to 14-month period of therapy with the combination of indapamide (2.5 mg/day) and fosinopril (10 mg/day)

three patients

achieve


Input: A reversible toxic liver damage was observed in a non-alcoholic woman treated with disulfiram.

a non-alcoholic woman

disulfiram

reversible toxic liver damage

damage


Input: A 60 year-old woman with chronic renal failure developed acute proximal muscle weakness after receiving a regular dosage of colchicine.

A 60 year-old woman with chronic renal failure

acute proximal muscle weakness

regular dosage of colchicine

developed


Input: The cause of these previously unreported side effects of niacin therapy is uncertain but may be related to prostaglandin-mediated vasodilatation, hyperalgesia of sensory nerve receptors, and potentiation of inflammation in the gingiva with referral of pain to the teeth.

niacin

prostaglandin-mediated vasodilatation, hyperalgesia of sensory nerve receptors, and potentiation of inflammation in the gingiva with referral of pain to the teeth

uncertain

related


Input: Nocardia is an important opportunistic infectious agent in immunocompromised hosts, i.e. in patients taking corticosteroids.

corticosteroids

immunocompromised hosts

Nocardia

infectious agent


Input: Hepatobiliary disorders associated with orally administered terbinafine have rarely been reported.

Hepatobiliary disorders

orally administered terbinafine

associated


Input: We report a patient in whom the anti-depressant trazodone hydrochloride (Molipaxin, Roussel), a serotonin antagonist, provoked generalized pustular psoriasis (GPP).

trazodone hydrochloride (Molipaxin, Roussel)

generalized pustular psoriasis (GPP)

a patient

provoked


Input: Early recognition of hereditary motor and sensory neuropathy type 1 can avoid life-threatening vincristine neurotoxicity.

Early recognition of hereditary motor and sensory neuropathy type 1

life-threatening

can


Input: Probable enoxaparin-induced hepatotoxicity.

enoxaparin

hepatotoxicity

induced


Input: Interstitial pneumonitis associated with sirolimus: a dilemma for lung transplantation.

Interstitial pneumonitis

sirolimus

associated


Input: He had also developed elevated serum ammonia levels while on valproic acid.

He

elevated serum ammonia levels

valproic acid

developed


Input: Cutaneous rashes and eruptions can be caused by many medications, including carbamazepine.

Cutaneous rashes and eruptions

carbamazepine

caused


Input: In this case, the increase in the INR value with associated bruising after the addition of amoxycillin suggests a drug interaction between acenocoumarol and amoxycillin, other possible causes having been eliminated.

the increase in the INR value with associated bruising

amoxycillin

suggests

after


Input: Oncologists supervising future clinical trials for lung cancer should be alert to the fact that sorafenib can potentially induce serious interstitial lung disease, although this might depend on racial differences.

sorafenib

serious interstitial lung disease

potentially

induce


Input: SUMMARY: A 26-year-old man with bipolar disorder, seizures, and mild mental retardation secondary to a traumatic brain injury began treatment with carbamazepine for aggression and seizure control.

carbamazepine

A 26-year-old man with bipolar disorder, seizures, and mild mental retardation secondary to a traumatic brain injury

treatment


Input: Serotonin toxicity precipitated by fentanyl is unusual and has not previously been described in combination with SSRIs in the perioperative setting.

Serotonin toxicity

fentanyl

unusual

precipitated


Input: It may cause a severe adverse drug reaction with multiorgan involvement known as dapsone hypersensitivity syndrome.

dapsone

hypersensitivity syndrome

a severe adverse drug reaction

may

cause


Input: Visual system side effects caused by parasympathetic dysfunction after botulinum toxin type B injections.

Visual system side effects caused by parasympathetic dysfunction

botulinum toxin type B injections

after


Input: Renal failure associated with acetazolamide therapy for glaucoma.

Renal failure

acetazolamide therapy

associated


Input: Acute onset of nephrotic syndrome during interferon-alpha retreatment for chronic active hepatitis C.

Acute onset of nephrotic syndrome

interferon-alpha retreatment

during


Input: A 16-year-old boy developed fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels while receiving treatment with olanzapine and lithium.

A 16-year-old boy

olanzapine and lithium

fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels

while


Input: The hyperpigmentation was diffuse scattered, flagellate like and linear streaking which was thought to be mainly related to the skin toxicity of bleomycin.

bleomycin

hyperpigmentation was diffuse scattered, flagellate like and linear streaking

mainly

toxicity


Input: Exacerbation of 5-FU dermatologic toxicities in patients with preexisting conditions suggests the importance of aggressive ocular prophylaxis, using frequent ocular lubrication and topical steroid preparations with concurrent medical management of pre-existing dermatologic conditions.

dermatologic toxicities

toxicities


Input: Bowel perforation associated with intraperitoneal chromic phosphate instillation.

intraperitoneal chromic phosphate instillation

Bowel perforation

associated


Input: A 62-year-old woman who was being treated for squamous cell carcinoma of the head and neck developed a chemotherapy-related hemolytic-uremic syndrome during the second cycle of neoadjuvant chemotherapy consisting of cisplatin, bleomycin, and methotrexate.

the second cycle of neoadjuvant chemotherapy consisting of cisplatin, bleomycin, and methotrexate

a chemotherapy-related hemolytic-uremic syndrome

A 62-year-old woman who was being treated for squamous cell carcinoma of the head and neck

developed


Input: These data confirm the therapeutic value of arsenic trioxide in relapsed/resistant APL.

arsenic trioxide

therapeutic value


Input: Avascular necrosis of the femoral head in patients with prostate cancer treated with cyproterone acetate and radiotherapy.

Avascular necrosis of the femoral head

patients with prostate cancer

cyproterone acetate and radiotherapy

in


Input: Ectropion secondary to bolus injection of 5-fluorouracil.

Ectropion

bolus injection of 5-fluorouracil

secondary


Input: Metoclopramide-induced parkinsonism is not rare, and appropriate dose reduction in patients with renal failure will help reduce the incidence of this morbidity.

Metoclopramide

parkinsonism

patients with renal failure

induced


Input: Posterior reversible encephalopathy syndrome associated with methotrexate neurotoxicity: conventional magnetic resonance and diffusion-weighted imaging findings.

Posterior reversible encephalopathy syndrome

methotrexate neurotoxicity

associated


Input: A 6-year-old boy (weight: 16 kg, at the start of treatment) began sodium valproate (valproate syrup 5%) treatment for epilepsy in February 2012.

A 6-year-old boy (weight: 16 kg, at the start of treatment)

sodium valproate (valproate syrup 5%)

treatment


Input: Pharmacokinetic determinants of 6-mercaptopurine myelotoxicity and therapeutic failure in children with acute lymphoblastic leukemia.

myelotoxicity and therapeutic failure

children with acute lymphoblastic leukemia

in


Input: We report the case histories of identical twin brothers who developed concordant acute lymphoblastic leukemia at the age of 4 years and who later developed leukoencephalopathy and hydrocephalus related to central nervous system prophylaxis by, in the first case intrathecally administered methotrexate and, in the second by intrathecally administered methotrexate and cranial irradiation.

identical twin brothers

leukoencephalopathy and hydrocephalus

intrathecally administered methotrexate

intrathecally administered methotrexate and cranial irradiation

developed


Input: Considering the increasing use of TMZ, which is regarded as a drug with moderate toxicity, careful follow-up with routine blood testing is vital.

moderate toxicity

TMZ

with


Input: While for ribavirin antidepressant effects are not known, we suppose that antidepressants may prevent changes in serotonergic or noradrenergic neurotransmission caused by IFN-alpha.

antidepressants

may

prevent

IFN-alpha

changes in serotonergic or noradrenergic neurotransmission

caused


Input: To report a case of serotonin syndrome associated with interaction between fentanyl and citalopram, as evidenced by medication history, clinical features and reversal following discontinuation of fentanyl.

serotonin syndrome

nteraction between fentanyl and citalopram

a case

associated


Input: We report a case of ibuprofen-induced meningitis in an otherwise healthy individual.

ibuprofen

meningitis

an otherwise healthy individual

induced


Input: The reported cases of in utero exposure to cyclosposphamide shared the following manifestations with our patient: growth deficiency, developmental delay, craniosynostosis, blepharophimosis, flat nasal bridge, abnormal ears, and distal limb defects including hypoplastic thumbs and oligodactyly.

growth deficiency, developmental delay, craniosynostosis, blepharophimosis, flat nasal bridge, abnormal ears, and distal limb defects including hypoplastic thumbs and oligodactyly

in utero exposure to cyclosposphamide

patient

shared


Input: L-Thyroxine-induced leukopenia in a patient with Hashimoto's disease: involvement of suppressor-cytotoxic T cells.

L-Thyroxine

leukopenia

a patient with Hashimoto's disease

induced


Input: Carbamazepine-induced systemic lupus erythematosus-like disease.

Carbamazepine

systemic lupus erythematosus-like disease

induced


Input: CONCLUSIONS: This case describes the clinically significant increase of INR in an elderly patient after adding a chemotherapy regimen of levamisole and 5-FU to a previous regimen of warfarin alone.

increase of INR

an elderly patient

levamisole and 5-FU

warfarin

significant

in


Input: These results suggest that the hepatoxicity of ethanol in alcoholic beverages is enhanced by interaction with its congeners and acetaldehyde; they also suggest that alcoholic beverages are not equivalent in their potential to cause liver damage.

hepatoxicity

alcoholic

potential

enhanced


Input: The dermatology literature heretofore has not noted that anemia is a side effect of patients taking MMF to treat pemphigus.

anemia

patients

MMF

not

is


Input: The 9 other reported cases of D-penicillamine induced rapidly progressive glomerulonephritis have been reviewed.

D-penicillamine

rapidly progressive glomerulonephritis

induced


Input: We describe a heroin abuser in whom clinical and laboratory manifestations of acute hepatitis B and C appeared a few days after the insertion of a subcutaneous naltrexone implant.

subcutaneous naltrexone implant

acute hepatitis B and C

a heroin abuser

after


Input: Ciprofloxacin-induced psychosis.

Ciprofloxacin

psychosis

induced


Input: Thalidomide was withdrawn from world markets in 1961 following recognition of its teratogenic effects.

teratogenic effects

Thalidomide

following


Input: Weekly AUC2 carboplatin in acquired platinum-resistant ovarian cancer with or without oral phenoxodiol, a sensitizer of platinum cytotoxicity: the phase III OVATURE multicenter randomized study.

Weekly AUC2 carboplatin

with or without oral phenoxodiol

in


Input: We suggest the use of esmolol for treatment of dysrhythmias secondary to caffeine toxicity; to the best of our knowledge, the use of esmolol has not been reported for this purpose.

esmolol

treatment


Input: To date, there have been few reports of visual disturbances associated with BTX-B use.

BTX-B

visual disturbances

associated


Input: Gemcitabine is a known risk factor for hemolytic uremic syndrome (HUS), which can often have a rapidly fatal clinical course despite intervention with steroids, plasmapheresis and hemodialysis.

Gemcitabine

hemolytic uremic syndrome

fatal

risk

with steroids, plasmapheresis and hemodialysis

intervention


Input: Our objective is to present a retrospective analysis of the DWI findings in four patients who suffered subacute neurotoxicity after intrathecal MTX.

intrathecal MTX

subacute neurotoxicity

four patients

after


Input: We report a case of ST elevation in right precordial leads compatible with type 1 Brugada syndrome following administration of propafenone in a patient with Wolff-Parkinson-White syndrome who was receiving lithium at concentrations within therapeutic levels.

administration of propafenone

receiving lithium at concentrations within therapeutic levels

ST elevation in right precordial leads compatible with type 1 Brugada syndrome

a patient with Wolff-Parkinson-White syndrome

following


Input: The spectrum of cutaneous eruptions associated with dihydropyridines is extensive, varying from exanthemas to severe adverse events.

dihydropyridines

cutaneous eruptions

exanthemas

associated


Input: Polymyositis after propylthiouracil treatment for hyperthyroidism.

Polymyositis

propylthiouracil

after


Input: Methamphetamine's extensive physiologic effects, inconsistent street purity, and multiple routes of administration offer many possibilities for injury to the cornea.

Methamphetamine's

offer


Input: Since ethambutol is actively excreted via the renal system, compromise of renal function such as due to renal tuberculosis may lead to serum concentration elevations of ethambutol sufficient to produce optic neuropathy.

ethambutol

serum concentration elevations of ethambutol sufficient to produce optic neuropathy

may

lead


Input: Renal failure appeared 8 to 17 days after beginning gentamicin therapy and was characterized by creatinine clearances 4 to 10 ml/min, urine to plasma creatinine ratios less than 20, urinary sodium concentrations 16 to 60 mEq/liter, proteinuria, and cylindruria.

gentamicin therapy

Renal failure

creatinine clearances 4 to 10 ml/min, urine to plasma creatinine ratios less than 20, urinary sodium concentrations 16 to 60 mEq/liter, proteinuria, and cylindruria

beginning


Input: Seizures associated with ofloxacin therapy.

Seizures

ofloxacin

associated


Input: Cutaneous seeding after ultrasound-guided percutaneous ethanol injection for treatment of hepatocellular carcinoma.

Cutaneous seeding

ultrasound-guided percutaneous ethanol injection

after


Input: Two patients who developed decreased visual acuity after several months of ethambutol treatment for Mycobacterium avium-intracellulare infection had bitemporal visual field defects that suggested optic chiasm damage.

Two patients

Mycobacterium avium-intracellulare infection

decreased visual acuity

bitemporal visual field defects

optic chiasm damage

ethambutol

after


Input: CONCLUSIONS: Metoclopramide may cause reversible nonthrombocytopenic vascular-type palpable purpura.

Metoclopramide

reversible nonthrombocytopenic vascular-type palpable purpura

may

cause


Input: CONCLUSIONS: Life-threatening adrenal suppression, requiring hydrocortisone supplementation and intensive therapy, was observed and successfully treated in a newborn, whose mother had received high-dose methylprednisolone in late pregnancy.

hydrocortisone supplementation and intensive therapy

successfully treated

a newborn, whose mother had received high-dose methylprednisolone in late pregnancy

requiring


Input: A case of extrapyramidal symptoms (EPS) following administration of aripiprazole to a man with developmental disabilities who had never received antipsychotic medications and had no history of movement disorders is presented.

extrapyramidal symptoms (EPS)

aripiprazole

a man with developmental disabilities who had never received antipsychotic medications and had no history of movement disorders is presented

following


Input: Although high-dose methotrexate has been shown to be useful in the treatment of primary osteogenic sarcoma, the tumoricidal effects of therapy appear to have caused a fatal rise in intracranial pressure.

high-dose methotrexate

a fatal rise in intracranial pressure

fatal

caused


Input: This case had radiation fibrosis, so we suggest that radiation fibrosis may be another contributor of the occurrence of ILD in patients taking erlotinib.

taking erlotinib

patients

occurrence of ILD

of


Input: Since recent studies have reported no negative interactions with concurrent use, we here report three cases (one case of a prolonged seizure, a serotonin syndrome and a focal seizure) of severe lithium-induced side effects while patients underwent ECT without complications and lithium serum levels were still subtherapeutic.

a prolonged seizure

lithium

induced

lithium

a serotonin syndrome

induced

lithium

a focal seizure

severe

induced

ECT

without complications and lithium serum levels were still subtherapeutic

underwent


Input: Lithium-associated transient thyrotoxicosis in 4 Chinese women with autoimmune thyroiditis.

4 Chinese women with autoimmune thyroiditis

Lithium

transient thyrotoxicosis

associated


Input: A patient, while on intravenous ritodrine therapy for preterm labor, experienced an episode of acute chest pain.

intravenous ritodrine therapy

an episode of acute chest pain

A patient

on


Input: Subsequent in vivo/vitro studies clearly demonstrated that the neurological effects were due to a synergistic action of desferrioxamine and prochlorperazine, probably resulting in exceptional fluxes of intra/extra cellular iron/copper disturbing noradrenergic and serotonergic systems.

desferrioxamine and prochlorperazine

neurological effects

probably

due


Input: Favorable outcome of de novo hepatitis B infection after liver transplantation with lamivudine and adefovir therapy.

after liver transplantation with lamivudine and adefovir therapy

outcome


Input: Pemphigus foliaceus was seen in a patient with pulmonary tuberculosis during rifampicin therapy.

Pemphigus foliaceus

a patient with pulmonary tuberculosis

rifampicin

seen


Input: CONCLUSIONS: Clinicians should be aware of a risk of serotonin syndrome with serious extrapyramidal reactions in patients receiving sertraline or venlafaxine when metoclopramide is coadministered even in a single, conventional dose.

patients

sertraline or venlafaxine when metoclopramide is coadministered even in a single, conventional dose

serotonin syndrome with serious extrapyramidal reactions

risk

receiving


Input: We report the case of a patient who developed polyserositis (pericardial effusion, pleural effusion, and pericarditis) after being started on clozapine, and whose symptoms remitted upon discontinuation of clozapine.

started on clozapine

polyserositis (pericardial effusion, pleural effusion, and pericarditis)

a patient

after


Input: Three years later, treatment with ampicillin caused another episode of cholestatic hepatitis with cholestasis and duct paucity on rebiopsy.

ampicillin

cholestatic hepatitis with cholestasis and duct paucity on rebiopsy

caused


Input: METHODS: A patient who developed dramatic, permanent vision loss after a 9-month course of treatment with ethambutol and isoniazid for pulmonary tuberculosis is presented.

A patient

9-month course of treatment with ethambutol and isoniazid

permanent vision loss

after


Input: The authors report a case of urinary incontinence (UI) that occurred in a woman after administration of venlafaxine.

a woman

urinary incontinence (UI)

venlafaxine

occurred


Input: The possibility can be raised that M-CSF accelerated the underlying renal disease in this case through enhancing macrophage accumulation into the glomerulus, leading to the development of nephrotic syndrome.

M-CSF

underlying renal disease in this case through enhancing macrophage accumulation into the glomerulus, leading to the development of nephrotic syndrome

possibility

accelerated


Input: We describe two ELBW infants affected by hyperkalaemia, treated with Kayexalate, who developed serious hypernatraemia, that has never been reported before in preterm infants.

Kayexalate

two ELBW infants affected by hyperkalaemia

serious hypernatraemia

serious

developed


Input: DISCUSSION: Electrolyte disorders associated with foscarnet are reviewed.

Electrolyte disorders

foscarnet

associated


Input: We report two cases that developed acute myeloid leukaemia (AML) during tamoxifen therapy for breast cancer.

acute myeloid leukaemia (AML)

tamoxifen therapy for breast cancer

two cases

developed


Input: Our patient was a 72-year-old man with advanced Parkinson's disease (PD) who received levodopa and anti-cholinergic drugs and whose head had become almost completely bald.

a 72-year-old man with advanced Parkinson's disease (PD)

levodopa and anti-cholinergic drugs

completely bald

become


Input: The patient experienced hallucinations, agitation, vomiting, tachycardia and seizures after ingestion of 1050 (48 mg/kg) of extended-release bupropion.

hallucinations, agitation, vomiting, tachycardia and seizures

ingestion of 1050 (48 mg/kg) of extended-release bupropion

experienced


Input: This case report describes a 38-year-old male in whom SIADH was strongly suspected secondary to Tegretol therapy to control a seizure disorder.

38-year-old male

a seizure disorder

Tegretol

SIADH

suspected


Input: However, cyclosporine dependency is associated with the risk of nephrotoxicity.

cyclosporine dependency

nephrotoxicity

associated


Input: The observations suggest that testicular swelling and pain are side effects of desipramine.

testicular swelling and pain

desipramine

side effects


Input: METHOD: We describe three case-reports concerning haematological adverse effects of quetiapine.

haematological adverse effects

quetiapine

adverse effects


Input: Typically, drug-induced neutropenia occurs in a patient receiving a semisynthetic penicillin for two weeks or more.

drug-induced neutropenia

a patient

a semisynthetic penicillin for two weeks or more

occurs


Input: Peripheral nerve dysfunction is a potentially serious complication of high-dose cytosine arabinoside.

Peripheral nerve dysfunction

cytosine arabinoside

potentially

of


Input: Tumor-volume increase at beginning of primary treatment with topical interferon alpha 2-beta in a case of conjunctiva-cornea intraepithelial neoplasia.

Tumor-volume increase

primary treatment with topical interferon alpha 2-beta

a case of conjunctiva-cornea intraepithelial neoplasia

increase


Input: L-asparaginase-induced posterior reversible encephalopathy syndrome during acute lymphoblastic leukemia treatment in children.

L-asparaginase

posterior reversible encephalopathy syndrome

children

induced


Input: On the other hand, MTX-induced pneumonitis seems to be very rare in psoriatic arthritis (PsA).

MTX

pneumonitis

seems

induced


Input: Ototoxicity as a result of cis-platinum administration is well documented.

Ototoxicity

cis-platinum administration

result


Input: Massive subfascial hematoma after alteplase therapy for acute myocardial infarction.

Massive subfascial hematoma

alteplase therapy

after


Input: We suggest that itraconazole should be added to the list of drugs that may be responsible for a drug-induced vanishing bile duct syndrome.

itraconazole

drug-induced vanishing bile duct syndrome

may

responsible


Input: A 67-year-old man receiving a stable maintenance dosage of warfarin experienced an increased international normalized ratio (INR) without bleeding when his atorvastatin therapy was switched to fluvastatin.

warfarin

increased international normalized ratio (INR)

A 67-year-old man

experienced

atorvastatin therapy was switched to fluvastatin

switched


Input: The cases of CBZ-induced SLE reported in the literature were reviewed.

CBZ

SLE

induced


Input: Ciprofloxacin-induced hemorrhagic vasculitis.

Ciprofloxacin

hemorrhagic vasculitis

induced


Input: INTERPRETATION: When high doses of fluticasone propionate are used, growth may be retarded and adrenal suppression may occur.

high doses of fluticasone propionate

growth may be retarded and adrenal suppression

occur


Input: To our knowledge, this is the first report of significant hypotension associated with intravenous valproate in the treatment of status epilepticus in the pediatric population.

hypotension

intravenous valproate

pediatric population

associated


Input: While undergoing treatment with albendazole, he developed worsening diarrhea with abdominal pain and fever.

albendazole

he

worsening diarrhea with abdominal pain and fever

developed


Input: Linezolid-associated peripheral and optic neuropathy, lactic acidosis, and serotonin syndrome.

Linezolid

peripheral and optic neuropathy, lactic acidosis, and serotonin syndrome.

associated


Input: Bone marrow aplasia and severe skin rash after a single low dose of methotrexate.

Bone marrow aplasia and severe skin rash

a single low dose of methotrexate

severe

after


Input: A woman 38-year-old, suffering for about ten years from multiple sclerosis and treated with repeated therapy cycles of intrathecal Depo-Medrol, developed a spastic paraparesis at the lower limbs.

A woman 38-year-old, suffering for about ten years from multiple sclerosis

repeated therapy cycles of intrathecal Depo-Medrol

a spastic paraparesis at the lower limbs

developed


Input: The efficacy of single-dose disulfiram as an inhibitor of human P450 2E1 suggests that this modality for manipulating clinical P450 2E1 activity may provide a useful probe for delineating P450 2E1 participation in human drug biotransformation or for the treatment of poisoning by P450 2E1-activated toxins.

poisoning

P450 2E1-activated toxins

by


Input: To develop information on the relative rarity or frequency of neurologic worsening with the initiation of penicillamine therapy, we conducted a retrospective survey of 25 additional patients with Wilson's disease who met the criteria of presenting with neurologic disease and having been treated with penicillamine.

25 additional patients with Wilson's disease

neurologic disease

penicillamine

presenting


Input: The authors present a case of t-AML that developed in a child with metastatic neuroblastoma 18 months after he received oral etoposide, given for palliation purpose.

oral etoposide

t-AML

a child with metastatic neuroblastoma

after


Input: Mechanisms and triggering factors of hypoglycaemia induced by mefloquine and some other anti-malarial quinine analogues are discussed.

hypoglycaemia

mefloquine and some other anti-malarial quinine analogues

induced


Input: Only nondepolarizing muscle relaxants should be used in patients who are at risk for mucositis.

nondepolarizing muscle relaxants

patients who are at risk for mucositis

should

used


Input: CONCLUSION: A possible pharmacokinetic interaction between Dantrolene and Oxybutynin should be borne in mind when considering Carbamazepine medication for a patient with a spinal cord lesion.

a patient

Carbamazepine medication

medication


Input: We describe a 15-year-old female patient diagnosed with acute lymphoblastic leukemia presenting with status epilepticus after receiving intrathecal methotrexate.

a 15-year-old female patient diagnosed with acute lymphoblastic leukemia

presenting with status epilepticus

receiving intrathecal methotrexate

after


Input: Duodenal ulceration: a complication of tolazoline therapy.

tolazoline

Duodenal ulceration

complication


Input: Hepatic damage after danazol treatment.

Hepatic damage

danazol

after


Input: Hepato-biliary abnormalities secondary to ceftriaxone use: a case report.

Hepato-biliary abnormalities

ceftriaxone use

secondary to


Input: Rhabdomyolysis with concurrent atorvastatin and diltiazem.

Rhabdomyolysis

diltiazem

atorvastatin

with


Input: Case report: mannitol nephrotoxicity syndrome: role of hemodialysis and postulate of mechanisms.

mannitol

nephrotoxicity

syndrome


Input: Uveitis during treatment of disseminated Mycobacterium avium-intracellulare complex infection with the combination of rifabutin, clarithromycin and ethambutol.

Uveitis

combination of rifabutin, clarithromycin and ethambutol

during


Input: The visual loss in this patient seems to result from phenol neurotoxicity rather than mechanical compression of the intraorbital optic nerve.

visual loss

neurotoxicity

patient

phenol

result


Input: Polysomnographic and pharmacokinetic findings in levodopa-induced augmentation of restless legs syndrome.

augmentation of restless legs syndrome

levodopa

induced


Input: These cases highlight the occurrence of livedo reticularis as an uncommon side-effect of interferon alpha treatment.

These cases

livedo reticularis

interferon alpha

side-effect


Input: So far, few cases of pulmonary side effects caused by ticlopidine have been reported.

pulmonary side effects

ticlopidine

few cases

caused


Input: Abnormal dexamethasone suppression tests in a rifampicin-treated patient with suspected Cushing's syndrome.

Abnormal dexamethasone suppression tests

rifampicin

patient with suspected Cushing's syndrome

suspected

Abnormal


Input: Gemcitabine therapy has been associated with radiation recall reactions when used in the treatment of carcinoma.

Gemcitabine

radiation recall reactions

associated


Input: Increased lash length, thickness, and pigmentation are well-documented side effects of prostaglandin analog glaucoma drops.

Increased lash length, thickness, and pigmentation

prostaglandin analog glaucoma drops

are


Input: Bullous Eruption Associated With Dihydropyridines With Cross Reactivity.

Dihydropyridines

Bullous Eruption

Associated


Input: Ritonavir acted as a CYP3A4 inhibitor, diminishing carbamazepine metabolism and provoking an increase in serum levels and clinical toxicity.

Ritonavir

CYP3A4 inhibitor, diminishing carbamazepine metabolism and provoking an increase in serum levels and clinical toxicity

acted


Input: Acute generalized exanthematous pustulosis induced by nimesulide.

Acute generalized exanthematous pustulosis

nimesulide

induced


Input: Quinine induced coagulopathy--a near fatal experience.

Quinine

coagulopathy--a near fatal experience

fatal

induced


Input: A 58-year-old man with rheumatoid arthritis developed lichen planus during treatment with gold.

treatment with gold

lichen planus during

A 58-year-old man with rheumatoid arthritis

developed


Input: Atenolol-induced pseudolymphoma.

Atenolol

pseudolymphoma

induced


Input: First case report of suspected onset of convulsive seizures due to co-administration of valproic acid and tebipenem.

convulsive seizures

co-administration of valproic acid and tebipenem

due


Input: Fluoxetine-related death in a child with cytochrome P-450 2D6 genetic deficiency.

Fluoxetine

child with cytochrome P-450 2D6 genetic deficiency

death

related


Input: Aplastic anemia and agranulocytosis in patients using methazolamide for glaucoma.

Aplastic anemia and agranulocytosis

patients

glaucoma

methazolamide

in


Input: We report a 44-year-old woman with t-MDS (refractory anemia with excess blasts) following treatment of recurrent anaplastic astrocytoma with temozolomide (TMZ).

a 44-year-old woman

t-MDS (refractory anemia with excess blasts)

treatment of recurrent anaplastic astrocytoma with temozolomide (TMZ)

following


Input: An infant who developed pancreatitis during meglumine antimoniate treatment for visceral leishmaniasis and who was successfully treated with a combination of allopurinol and ketoconazole is reported.

a combination of allopurinol and ketoconazole

pancreatitis

An infant

treated


Input: L-Carnitine supplementation has been recommended to prevent the fatal hepatotoxic effects associated with valproic acid.

valproic acid

hepatotoxic effects

fatal

associated

L-Carnitine

recommended


Input: The purpose of this study was to examine the incidence and cause of Clostridium difficile colitis occurring after cisplatin-based combination chemotherapy in ovarian cancer patients.

Clostridium difficile colitis

cisplatin-based combination chemotherapy

ovarian cancer patients

occurring


Input: Cerebral demyelinating disease developed in a patient during adjuvant therapy with levamisole for malignant melanoma.

adjuvant therapy with levamisole

a patient

Cerebral demyelinating disease

during


Input: Amoxapine-induced cognitive impairment in two patients.

Amoxapine

two patients

cognitive impairment

induced


Input: Granisetron hydrochloride (3 mg on days 1, 8, and 15) and dexamethasone (13.2 mg on day 1 and 6.6 mg on days 2, 3, 8, and 15) were used prior to irinotecan administration in both patients.

Granisetron hydrochloride (3 mg on days 1, 8, and 15) and dexamethasone (13.2 mg on day 1 and 6.6 mg on days 2, 3, 8, and 15)

irinotecan

both patients

used


Input: Visceral herpesvirus infections in leukemic patients receiving cytarabine.

Visceral herpesvirus infections

cytarabine

leukemic patients

in


Input: Although a few case reports link metronidazole with the development of pseudomembranous colitis, albendazole has not been associated with the development of this condition.

metronidazole

pseudomembranous colitis

development


Input: CONCLUSION: Oral mucositis is a frequent and potentially severe complication of cancer chemotherapy.

Oral mucositis

cancer chemotherapy

potentially

severe

complication


Input: One case of priapism occurred during heparin therapy for a previous surgical operation to the knee is reported.

during heparin therapy

priapism

One case

occurred


Input: While both amiodarone and digoxin can cause permanent visual changes, the ocular effects are often reversible.

amiodarone and digoxin

permanent visual changes

cause


Input: AIM: Report of a case of a woman patient who developed celiac disease after pegylated interferon alpha-2a and ribavirin use for chronic hepatitis C.

a woman patient

celiac disease

pegylated interferon alpha-2a and ribavirin use for chronic hepatitis C

developed


Input: Differential diagnoses included ocular rosacea with cicatrizing conjunctivitis and 5-FU-induced ectropion.

ectropion

induced


Input: In rare cases mitomycin C (MMC) may induce cancer-associated hemolytic uremic syndrome, which is characterized by hemolytic anemia, thrombocytopenia and progressive renal failure.

mitomycin C (MMC)

cancer-associated hemolytic uremic syndrome

hemolytic anemia, thrombocytopenia and progressive renal failure

In rare cases

may

induce


Input: Hemolytic uremic syndrome following the infusion of oxaliplatin: case report.

oxaliplatin

Hemolytic uremic syndrome

following


Input: Tacrolimus (FK506)-induced mutism after liver transplant.

Tacrolimus (FK506

mutism

induced


Input: Though proteinuria and nephrotic syndrome is a rare adverse effect of IFN-beta-1b therapy, physicians treating MS patients with this agent should pay careful attention to new clinical symptoms and laboratory findings.

proteinuria and nephrotic syndrome

MS patients

adverse effect


Input: It is suggested that the patient had sulfasalazine-induced lupus, which manifested with serositis and pulmonary parenchymal involvement in the absence of joint symptoms.

sulfasalazine

lupus, which manifested with serositis and pulmonary parenchymal involvement in the absence of joint symptoms

induced


Input: By means of the in vitro heparin-induced platelet activation (HIPA) assay it was shown that standard heparin and the LMW heparins Fragmin and Fraxiparin (Sanofi Labaz, Munich, FRG), as well as the enoxaparine Clexane (Nattermann, Cologne, FRG), all induced platelet activation with the patient's serum.

platelet activation

standard heparin and the LMW heparins Fragmin and Fraxiparin (Sanofi Labaz, Munich, FRG), as well as the enoxaparine Clexane (Nattermann, Cologne, FRG)

induced


Input: DISCUSSION: This case shows that switching to zidovudine potentially can lead to a hyperlactatemia relapse.

hyperlactatemia relapse

This case

zidovudine

potentially

lead


Input: Acute leukaemia during tamoxifen therapy.

Acute leukaemia

tamoxifen therapy

during


Input: Heparin-associated thrombocytopenia: successful therapy with the heparinoid Org 10172 in a patient showing cross-reaction to LMW heparins.

Heparin

thrombocytopenia

a patient

associated


Input: A patient presented with a painful, oedematous, cyanosed hand having injected a solution of diamorphine and methylphenidate into his radial artery.

A patient

injected a solution of diamorphine and methylphenidate into his radial artery

painful, oedematous, cyanosed hand

presented


Input: We conclude that vincristine and actinomycin D were the cause of this rare from of hepatotoxicity and that chemotherapy for the underlying malignant disease could be given safely after clinical recovery.

vincristine and actinomycin D

hepatotoxicity

cause


Input: Pure red cell aplasia associated with fenoprofen.

Pure red cell aplasia

fenoprofen

associated


Input: A 56-year-old white woman with a diagnosis of reactive depression developed severe UI after a 30 days' treatment with venlafaxine 75 mg/day.

A 56-year-old white woman with a diagnosis of reactive depression

severe UI

30 days' treatment with venlafaxine 75 mg/day.

after


Input: PATIENTS: Three patients developed a reproductive endocrine disorder during treatment with valproate.

Three patients

reproductive endocrine disorder

valproate

developed


Input: OBJECTIVE: To report a case of marked elevation of serum creatine kinase (CK) associated with olanzapine therapy.

olanzapine

marked elevation of serum creatine kinase

associated


Input: Severe C. difficile colitis occurred in 2 patients (6.1%) after receiving cisplatin-based combination chemotherapy for ovarian malignancies.

Severe C. difficile colitis

2 patients (6.1%)

cisplatin-based combination chemotherapy

Severe

occurred


Input: A 56-year-old woman with scleroderma developed rapidly progressive glomerulonephritis with epithelial crescents associated with hemoptysis after 27 months of D-penicillamine therapy and a cumulative dose of 1,200 g.

A 56-year-old woman with scleroderma

rapidly progressive glomerulonephritis with epithelial crescents associated with hemoptysis

27 months of D-penicillamine therapy and a cumulative dose of 1,200 g

developed


Input: High-dose phosphate treatment leads to hypokalemia in hypophosphatemic osteomalacia.

High-dose phosphate

hypokalemia

leads


Input: We report a patient who developed heparin associated thrombocytopenia during continuous arteriovenous haemofiltration and discuss its implications and alternative anticoagulant treatment.

heparin

continuous arteriovenous haemofiltration

a patient

heparin associated thrombocytopenia

during


Input: We describe a detailed case of fulminant hepatitis induced by nevirapine (Viramune) and treated by liver transplantation.

fulminant hepatitis

nevirapine

induced


Input: The literature is also reviewed for ARF associated with mannitol infusion in patients who received dialysis and those who did not receive dialysis; and the possible mechanism(s) of mannitol nephrotoxicity are discussed.

ARF

mannitol infusion

patients

associated


Input: In this case report, we present clinical and laboratory findings of a case with chronic hepatitis B that developed acute dystonia soon after the first dose of pegylated interferon alpha.

the first dose of pegylated interferon alpha.

acute dystonia

a case with chronic hepatitis B

acute

after


Input: Trichiasis associated with prostaglandin analog use.

Trichiasis

prostaglandin analog

associated


Input: The possible development of a drug-induced vasculitis or lupus-like syndrome should be added to the list of rare toxic effects of vancomycin.

vancomycin

drug-induced vasculitis or lupus-like syndrome

possible

development


Input: Healthcare professionals should be aware of the possible development of serotonin syndrome as a complication of initiation of fentanyl and other phenylpiperidine opioids in patients treated with SSRIs.

fentanyl and other phenylpiperidine opioids

treated with SSRIs

patients

serotonin syndrome

possible

development


Input: Acute myocardial ischemia following accidental intravenous administration of epinephrine in high concentration.

Acute myocardial ischemia

accidental intravenous administration of epinephrine in high concentration

following


Input: Bromide intoxication secondary to pyridostigmine bromide therapy.

Bromide intoxication

pyridostigmine bromide

secondary


Input: We have recently encountered a patient with acquired haemophilia who developed a thrombotic left middle cerebral artery distribution stroke while being treated with pFVIII.

pFVIII

patient with acquired haemophilia who developed a thrombotic left middle cerebral artery distribution stroke

thrombotic left middle cerebral artery distribution stroke

treated


Input: We present a case of serotonin syndrome, which was precipitated by this medicine in a patient who had been predisposed by long-term treatment with sertraline, a selective serotonin reuptake inhibitor.

serotonin syndrome

a patient

long-term treatment with sertraline

precipitated


Input: Of the 15 patients treated with tizanidine and mexiletine, 4 suffered tizanidine-induced adverse effects such as drowsiness and dry mouth in the retrospective survey.

tizanidine and mexiletine

drowsiness and dry mouth

15 patients

induced


Input: Type I second-degree AV block (Mobitz type I, Wenckebach AV block) during ritodrine therapy for preterm labor.

Type I second-degree AV block (Mobitz type I, Wenckebach AV block)

ritodrine

during


Input: After other potential causes of liver toxicity were excluded, TMP-SMX was determined to be the cause of his acute liver toxicity.

TMP-SMX

acute liver toxicity

determined


Input: One of the patients had a dexamethasone dependent brain metastatic condition.

One of the patients

dexamethasone

brain metastatic condition

had


Input: Biomicroscopy revealed amiodarone corneal deposits.

Biomicroscopy

amiodarone corneal deposits

revealed


Input: This case and a review of the literature show the severe and unpredictable nature of ethambutol toxicity and its potential for irreversible vision loss despite careful ophthalmologic monitoring.

ethambutol

irreversible vision loss

potential

severe

unpredictable


Input: Recently, some studies have also reported association between patients with juvenile rheumatoid arthritis (JRA) treated with Methotrexate (MTX) and malignant lymphoma developing.

Methotrexate (MTX)

malignant lymphoma

patients with juvenile rheumatoid arthritis (JRA

association


Input: The two middle aged women presented with respiratory symptoms after prolonged treatment with nitrofurantoin.

The two middle aged women

respiratory symptoms

prolonged treatment with nitrofurantoin

presented


Input: OBJECTIVE: 1) To describe a patient with rheumatoid arthritis receiving adalimumab who developed fever, pancytopenia, splenomegaly, and extreme hyperferritinemia.

fever, pancytopenia, splenomegaly, and extreme hyperferritinemia

a patient with rheumatoid arthritis

adalimumab

developed


Input: Visual hallucinations associated with zonisamide.

Visual hallucinations

zonisamide

associated with


Input: Milk-alkali syndrome induced by 1,25(OH)2D in a patient with hypoparathyroidism.

Milk-alkali syndrome

a patient with hypoparathyroidism.

induced


Input: We report the case of a female acromegalic patient in whom multiple hepatic adenomas appeared soon after danazol treatment for uterine fibromatosis.

a female acromegalic patient

hepatic adenomas

danazol treatment

appeared


Input: Carbamazepine toxicity induced by clarithromycin coadministration in psychiatric patients.

psychiatric patients

Carbamazepine toxicity

clarithromycin

induced


Input: Thrombolytic therapy with tissue plasminogen activator (tPA) for acute myocardial infarction may result in major bleeding complications such as gastrointestinal or intracranial bleeding.

tissue plasminogen activator

gastrointestinal or intracranial bleeding

may

result


Input: CONCLUSION: The hemolytic-uremic syndrome may be a rare complication of oxaliplatin-based chemotherapy.

hemolytic-uremic syndrome

oxaliplatin-based chemotherapy

may

complication


Input: However, recurrent staphylococcus aureus sepsis developed during CyA therapy.

CyA therapy

staphylococcus aureus sepsis

developed


Input: Nabumetone-associated interstitial nephritis.

Nabumetone

interstitial nephritis

associated


Input: A short review on imatinib-related hepatotoxicity is also presented.

imatinib

hepatotoxicity

related


Input: Fatal interstitial pneumonitis associated with docetaxel administration in a patient with hormone-refractory prostate cancer.

Fatal interstitial pneumonitis

docetaxel

a patient with hormone-refractory prostate cancer

Fatal

associated


Input: BACKGROUND: Etanercept is a tumor necrosis factor (TNF) inhibitor that has been licensed in the United States for the treatment of adult and juvenile rheumatoid arthritis as well as psoriatic arthritis.

Etanercept

a tumor necrosis factor (TNF) inhibitor

adult and juvenile rheumatoid arthritis as well as psoriatic arthritis

licensed


Input: Reye-like syndrome following treatment with the pantothenic acid antagonist, calcium hopantenate.

Reye-like syndrome

calcium hopantenate

following


Input: Sudden death in an infant from methemoglobinemia after administration of "sweet spirits of nitre".

Sudden death

methemoglobinemia

an infant

sweet spirits of nitre

after


Input: FINDINGS: Six children with growth retardation noted after treatment with high-dose fluticasone propionate were found to have adrenal suppression.

Six children with growth retardation

high-dose fluticasone propionate

adrenal suppression

have


Input: Methotrexate-associated nephropathy is a rare complication in pediatric oncology, and a review of the literature suggests that exposure to nephrotoxic agents may be a significant but perhaps underrecognized risk factor for its development.

Methotrexate

nephropathy

may

rare

associated


Input: Four cases of oesophageal damage associated with ingestion of the urinary anti-spasmodic agent emepronium bromide are described.

Four cases

oesophageal damage

ingestion of the urinary anti-spasmodic agent emepronium bromide

associated


Input: A 66-year-old Japanese woman with severe scleroderma developed anemia and thrombocytopenia due to D-penicillamine (D-Pen) treatment, although the leukopenia was not markedly severe.

A 66-year-old Japanese woman with severe scleroderma

anemia and thrombocytopenia

D-penicillamine (D-Pen) treatment

developed


Input: Corticosteroid injections are commonly used as effective treatments for a variety of pain disorders.

Corticosteroid injections

treatments


Input: We present two cases of anaphylaxis under anaesthesia where return of spontaneous circulation was refractory to epinephrine, but occurred following the administration of the alpha-agonist metaraminol.

epinephrine

administration of the alpha-agonist metaraminol

return of spontaneous circulation

occurred


Input: A 51-yr-old nonsmoking male patient without any history of previous allergies, asthma, hay fever, or urticaria developed attacks of asthma when captopril was added to the nadolol and dyazide treatment for his high blood pressure.

A 51-yr-old nonsmoking male patient without any history of previous allergies, asthma, hay fever, or urticaria

attacks of asthma

captopril was added to the nadolol and dyazide

developed


Input: After ticlopidine was discontinued, the patient was rechallenged with the same dose of phenytoin without symptoms of toxicity.

toxicity

After ticlopidine was discontinued

rechallenged with the same dose of phenytoin

without

toxicity


Input: Rhabdomyolysis due to an uncommon interaction of ciprofloxacin with simvastatin.

Rhabdomyolysis

interaction of ciprofloxacin with simvastatin

due


Input: After receiving 3 doses of ifosfamide/mesna, she was found to be unresponsive.

ifosfamide/mesna

unresponsive

she

found


Input: Symptomatic hypoglycemia secondary to a glipizide-trimethoprim/sulfamethoxazole drug interaction.

Symptomatic hypoglycemia

glipizide-trimethoprim/sulfamethoxazole drug interaction

secondary to


Input: A 51-year-old man developed type 1 diabetes mellitus following 24 weeks of treatment with recombinant alpha-2b peginterferon plus ribavirin for chronic hepatitis C.

A 51-year-old man

type 1 diabetes mellitus

24 weeks of treatment with recombinant alpha-2b peginterferon plus ribavirin

developed


Input: A noninvasive method in the differential diagnosis of vecuronium-induced and magnesium-induced protracted neuromuscular block in a severely preeclamptic patient.

vecuronium

protracted neuromuscular block

severely preeclamptic patient

induced

protracted neuromuscular block

severely preeclamptic patient

magnesium

induced


Input: Paroxysmal supraventricular tachycardia during treatment with cisplatin and etoposide combination.

Paroxysmal supraventricular tachycardia

cisplatin and etoposide combination

during


Input: Conversely, diffuse interstitial pulmonary fibrosis should be considered in the differential diagnosis of patients receiving methotrexate who develop bilateral pulmonary infiltrates seen on chest roentgenograms.

methotrexate

diffuse interstitial pulmonary fibrosis

bilateral pulmonary infiltrates

patients

should be considered

develop


Input: An 83-year-old man receiving glipizide 10 mg bid developed symptomatic hypoglycemia within three days of adding trimethoprim/sulfamethoxazole (TMP/SMX) to his regimen.

symptomatic hypoglycemia

receiving glipizide 10 mg

three days of adding trimethoprim/sulfamethoxazole (TMP/SMX)

An 83-year-old man

developed


Input: In this case senna was likely the cause of a subacute cholestatic hepatitis exemplifying again the potential role of herbal related liver injury.

senna

a subacute cholestatic hepatitis

herbal related liver injury

likely

cause


Input: Early peritoneal dialysis has not previously been reported for lisinopril induced multiorgan failure.

lisinopril

multiorgan failure

induced


Input: Various case reports concerning dapsone-induced agranulocytosis are reviewed.

dapsone

agranulocytosis

induced


Input: We report the first case of a 54-year-old Turkish woman who presented with ceftriaxone-induced FDE.

a 54-year-old Turkish woman

ceftriaxone

FDE

induced


Input: In all cases, seizures were controlled by withdrawal of phenytoin and reduction of drug levels.

withdrawal of phenytoin and reduction of drug levels

seizures

controlled


Input: This case describes fulminant hepatic failure in a patient taking disulfiram with no previous liver disease and report of being compliant with alcohol abstinence.

fulminant hepatic failure

a patient

disulfiram

in


Input: Fungal infection is a significant comorbidity in patients with diabetes mellitus, and ketoconazole, an antifungal agent, causes a number of drug interactions with coadministered drugs.

patients with diabetes mellitus

ketoconazole

a number of drug interactions with coadministered drugs

causes


Input: Dorzolamide-induced choroidal detachment in a surgically untreated eye.

Dorzolamide

choroidal detachment

a surgically untreated eye

induced


Input: Idiosyncratic factors involving vasopressin receptor affinity and distribution, vasopressin-associated vasodilation in some vascular beds, and the effect of vasopressin on the renin-angiotensin system may further contribute to impaired tissue perfusion.

vasopressin

impaired tissue perfusion

contribute


Input: Rapid resolution of topiramate-induced angle-closure glaucoma with methylprednisolone and mannitol.

methylprednisolone and mannitol

resolution

topiramate

angle-closure glaucoma

induced


Input: A 66-year-old mand suffering from severe coronary heart disease took digoxin with suicidal intent an was treated for the ensuing complete atrioventricular block with digoxin-specific antibody fragments.

A 66-year-old mand suffering from severe coronary heart disease

digoxin

complete atrioventricular block

took


Input: A patient with generalized MG was effectively managed with MM but developed CNS lymphoma after 3 years of treatment.

MM

managed

A patient with generalized MG

MM

CNS lymphoma

developed


Input: Epoprostenol may be associated rarely with severe erythroderma.

Epoprostenol

severe erythroderma.

may

severe

associated


Input: We report the case of a patient with increased cerebral cortical excitability following intoxication with flupirtine, a centrally acting analgesic and antispastic drug.

a patient

increased cerebral cortical excitability

flupirtine

following


Input: This case represents the third example of erythroid aplasia associated with an anti-inflammatory agent and the first instance due to fenoprofen.

fenoprofen

erythroid aplasia

associated


Input: Lichenoid drug eruption to salsalate.

Lichenoid drug eruption

salsalate

eruption


Input: Two pediatric oncology patients with Ewing's sarcoma and one with mixed germ cell tumor were treated with drug regimens that included bleomycin or cyclophosphamide.

drug regimens that included bleomycin or cyclophosphamide

Two pediatric oncology patients with Ewing's sarcoma and one with mixed germ cell tumor

treated with


Input: Although retinoic acid is well tolerated by the majority of patients with this disease, a potentially fatal complication of this kind of treatment has been reported: "the retinoic acid syndrome".

retinoic acid

fatal complication

potentially

fatal

complication


Input: Three of 38 children given high-dose cytosine arabinoside therapy developed a previously undescribed complication.

38 children

high-dose cytosine arabinoside

complication

developed


Input: A case of aseptic pleuropericarditis in a patient with chronic plaque psoriasis under methotrexate therapy.

a patient with chronic plaque psoriasis

methotrexate therapy

aseptic pleuropericarditis

in


Input: Linezolid-induced dyserythropoiesis: chloramphenicol toxicity revisited.

Linezolid

dyserythropoiesis

induced


Input: CONCLUSION: The present findings suggest that fluvoxamine can cause increased libido in some patients.

increased libido

some patients

fluvoxamine

cause


Input: A unique case of a transient, nonpigmenting fixed drug eruption caused by the radiopaque contrast medium iothalamate is reported.

iothalamate

a transient, nonpigmenting fixed drug eruption

caused


Input: Mucosal pigmentation after oral lichen planus treatment with topical tacrolimus.

Mucosal pigmentation

topical tacrolimus

treatment


Input: We now report the first known cancer patient who developed life-threatening complications after treatment with topical 5-FU and was shown subsequently to have profound DPD deficiency.

cancer patient

life-threatening complications

have profound DPD deficiency

topical 5-FU

life-threatening

developed


Input: When the acute manic state is characterized by marked psychotic symptoms and intense anxiety, it may be associated with increased vulnerability to the development of severe lithium neurotoxicity.

lithium

acute manic state is characterized by marked psychotic symptoms and intense anxiety

may

associated with


Input: Clinicians who manage cachectic patients, particularly those with protracted diarrhoea and/or receiving anti-malarial drugs including mefloquine, should be aware of the risk of severe hypoglycaemia.

cachectic patients

with protracted diarrhoea

anti-malarial drugs including mefloquine

severe hypoglycaemia

risk

severe

risk


Input: Arrhythmias and cardiac arrest have been reported during amphotericin B administration but no effective technique has been described to prevent them.

amphotericin B administration

Arrhythmias and cardiac arrest

during


Input: Based upon the literature review, the hypotension in this patient was possibly due to the interaction between tizanidine and lisinopril.

the hypotension

the interaction between tizanidine and lisinopril

this patient

possibly

due


Input: Baclofen withdrawal: a cause of prolonged fever in the intensive care unit.

Baclofen withdrawal

prolonged fever

cause