Input: We report on three patients who developed acute liver damage during therapy with itraconazole, and in whom liver biopsy specimens were obtained.

three patients

acute liver damage

itraconazole

developed


Input: METHODS: A 68-year-old man developed intense conjunctival hyperemia and cystoid macula edema after switching from latanoprost to bimatoprost 9 months after cataract surgery in an eye at low-risk for this cystoid macular edema.

A 68-year-old man

intense conjunctival hyperemia and cystoid macula edema

bimatoprost

developed


Input: Tacrolimus (FK506), an immunosuppressant, has been associated with mutism in adults after liver transplant.

Tacrolimus (FK506), an immunosuppressant

mutism

adults after liver transplant

associated with


Input: Gemcitabine-induced pulmonary toxicity is usually a dramatic condition.

Gemcitabine

pulmonary toxicity

dramatic

induced


Input: However, the amount of prednisone required to maintain normotension resulted in Cushingoid features and has been discontinued.

Cushingoid features

prednisone

to maintain normotension

resulted in


Input: We present the case of a woman undergoing treatment with acenocoumarol for deep vein thrombosis, who maintained an international normalized ratio (INR) of between 2.5 and 4 for 2 months.

a woman

acenocoumarol

treatment


Input: Development of tics in a thirteen-year-old male following atomoxetine use.

atomoxetine

Development of tics

a thirteen-year-old male

following


Input: OBJECTIVE: To report a case of chronic, nonproductive cough secondary to the angiotensin-converting enzyme (ACE) inhibitor quinapril, with complete resolution after switching to another ACE inhibitor, fosinopril.

chronic, nonproductive cough secondary to the angiotensin-converting enzyme (ACE) inhibitor quinapril

switching to another ACE inhibitor, fosinopril

resolution


Input: Cholelithiasis and thrombosis of the central retinal vein in a renal transplant recipient treated with cyclosporin.

a renal transplant recipient

cyclosporin

Cholelithiasis and thrombosis of the central retinal vein

in


Input: We report a case of hepatolithiasis (intrahepatic stone) complicated by gram-negative sepsis in a 37 year old male with acromegaly being treated with octreotide.

hepatolithiasis (intrahepatic stone) complicated by gram-negative sepsis

a 37 year old male with acromegaly

octreotide

in


Input: Proliferation of abnormal bone marrow histiocytes, an undesired effect of granulocyte macrophage-colony-stimulating factor therapy in a patient with Hurler's syndrome undergoing bone marrow transplantation.

Proliferation of abnormal bone marrow histiocytes

granulocyte macrophage-colony-stimulating factor

a patient with Hurler's syndrome

undesired effect


Input: We report 4 patients, 2 on methylphenidate and 2 on dextroamphetamine who presented with acral cyanosis, livedo reticularis, or Raynaud phenomenon.

dextroamphetamine

acral cyanosis, livedo reticularis, or Raynaud phenomenon

presented

acral cyanosis, livedo reticularis, or Raynaud phenomenon

methylphenidate

4 patients, 2 on

presented


Input: Described here are 2 patients who developed thrombotic microangiopathy of the kidneys after receiving high cumulative doses of the new anticancer drug gemcitabine.

thrombotic microangiopathy of the kidneys

gemcitabine

2 patients

receiving


Input: CONCLUSIONS: An objective causality assessment revealed that fluphenazine was the probable cause of NMS in this patient.

fluphenazine

NMS

patient

cause


Input: Like other atypical neuroleptics olanzapine is considered to show a reduced prevalence of extrapyramidal side effects when compared to classical neuroleptic drugs.

reduced prevalence of extrapyramidal side effects

olanzapine

show


Input: Based on our experience and on previously published data, serum ammonia levels appear to be indicated in all ED patients on valproic acid therapy who present with altered mental status.

valproic acid therapy

all ED patients

altered mental status

appear to be

present


Input: Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.

Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia)

myelosuppression, hypertension, hyperlipidemia, and infection

associated


Input: Enoxaparin-induced generalized exanthem.

generalized exanthem

Enoxaparin

induced


Input: Our cases constitute the most severe cases of benzarone hepatotoxicity reported so far, and comprise the first cases of (sub)fulminant hepatitis and cirrhosis related to benzarone.

benzarone

hepatotoxicity

(sub)fulminant hepatitis and cirrhosis

of


Input: Within 3 days after starting bismuth subsalicylate therapy, the patient's INR increased from 2.56 to 3.54 and minor bleeding was noted from the patient's tracheostomy site.

Within 3 days after starting bismuth subsalicylate therapy

the patient

INR increased from 2.56 to 3.54 and minor bleeding was noted from the patient's tracheostomy site

minor

noted


Input: After three weeks of carbamazepine therapy, the patient arrived at the emergency department (ED) with severe agitation and aggressive behavior.

patient

severe agitation and aggressive behavior

After three weeks of carbamazepine therapy

severe

After


Input: OBJECTIVE: To report a case of ciprofloxacin-induced psychosis and to discuss occurrence rates, risk factors, possible etiologies, preventive measures, and treatment courses for this adverse reaction.

ciprofloxacin

psychosis

induced


Input: A 77-year-old man developed ankle, hand, and facial swelling 2 weeks after starting rosiglitazone.

A 77-year-old man

ankle, hand, and facial swelling

2 weeks after starting rosiglitazone

developed


Input: Although rare, massive pulmonary embolus must be considered to be a major risk of thrombolytic therapy for deep venous thrombosis.

massive pulmonary embolus

thrombolytic

risk


Input: We report a case of hypoglycaemia after mefloquine therapy (1,500 mg over two days) for severe gastrointestinal cryptosporidiasis in a cachectic AIDS patient with protracted diarrhoea.

hypoglycaemia

mefloquine therapy (1,500 mg over two days)

a cachectic AIDS patient with protracted diarrhoea

after


Input: OBJECTIVE: To describe onset of syndrome of inappropriate antidiuretic hormone (SIADH) associated with vinorelbine therapy for advanced breast cancer.

syndrome of inappropriate antidiuretic hormone (SIADH)

vinorelbine

associated with


Input: The thiazolidinediones (rosiglitazone and pioglitazone), a new class of oral antidiabetic agents, are "insulin sensitizers" and exert direct effects on the mechanisms of insulin resistance.

thiazolidinediones

exert


Input: The exacerbation of psoriasis was accompanied by a massive induction of lesional type I interferon activity, detected by MxA expression after imiquimod therapy.

imiquimod

exacerbation of psoriasis

a massive induction of lesional type I interferon activity

detected


Input: Two patients treated with alprazolam had histories suggestive of a bipolar disorder and developed lithium-responsive manic episodes.

Two patients

alprazolam

lithium-responsive manic episodes

developed


Input: Cerebrovascular complications of L-asparaginase therapy in children with leukemia: aphasia and other neuropsychological deficits.

Cerebrovascular complications

aphasia and other neuropsychological deficits

L-asparaginase

children with leukemia

complications


Input: We report two patients who developed intense livedo reticularis clearly related to the administration of interferon alpha 2b as an adjuvant therapy for melanoma.

two patients

interferon alpha 2b as an adjuvant therapy for melanoma

intense livedo reticularis

related


Input: A case of SIADH associated with desipramine treatment in an elderly depressed woman is described.

SIADH

desipramine treatment

an elderly depressed woman

associated


Input: Niflumic acid-induced skeletal fluorosis: iatrogenic disease or therapeutic perspective for osteoporosis?

Niflumic acid

skeletal fluorosis

induced


Input: Both patients developed severe complications when treated with aminoglutethimide as a cancer hormonal therapy.

aminoglutethimide

Both patients

severe complications

severe

developed


Input: An 11-day-old infant became lethargic and apneic after a single drop of brimonidine.

An 11-day-old infant

lethargic and apneic

a single drop of brimonidine

became


Input: Investigations suggested that the dextrose, rather than any additives, was responsible for the reaction.

dextrose

the reaction

responsible


Input: Since renal insufficiency was induced by AMPH and the other antifungal drugs were ineffective, daily administration of 200 mg of ITCZ was initiated, and the inflammatory signs and symptoms gradually subsided.

daily administration of 200 mg of ITCZ

the inflammatory signs and symptoms gradually subsided.

initiated

renal insufficiency

AMPH

induced


Input: Correction of serum electrolyte imbalance prevents cardiac arrhythmia during amphotericin B administration.

cardiac arrhythmia

amphotericin B administration

during


Input: Acute myopathy with selective degeneration of myosin filaments following status asthmaticus treated with methylprednisolone and vecuronium.

Acute myopathy with selective degeneration of myosin filaments

methylprednisolone

vecuronium

following


Input: Presented is a case of acute renal failure induced by acetazolamide therapy for glaucoma.

acute renal failure

acetazolamide therapy for glaucoma

induced


Input: Cyanamide-induced liver dysfunction after abstinence in alcoholics: a long-term follow-up study on four cases.

Cyanamide

liver dysfunction

abstinence in alcoholics

induced


Input: Fewer subjects reported adverse events following treatment with desipramine alone than when receiving desipramine with cinacalcet (33 versus 86%), the most frequent of which (nausea and headache) have been reported for patients treated with either desipramine or cinacalcet.

desipramine or cinacalcet

nausea and headache

patients

reported


Input: Three patients developed proteinuria following gold therapy for rheumatoid arthritis.

Three patients

gold

proteinuria

following


Input: The authors report a case of a patient who received alteplase for acute myocardial infarction and developed spontaneous subfascial hematoma without any evidence of direct trauma.

a case of a patient

alteplase

spontaneous subfascial hematoma without any evidence of direct trauma

developed


Input: Ticlopidine-induced marrow aplasia treated with cyclosporine.

Ticlopidine

marrow aplasia

induced


Input: Dural sinus thrombosis developed in two children with acute lymphoblastic leukemia during induction treatment with vincristine sulfate, prednisone, and asparaginase.

Dural sinus thrombosis

two children with acute lymphoblastic leukemia

induction treatment with vincristine sulfate, prednisone, and asparaginase

developed


Input: Zolpidem (Ambien), a relatively new nonbenzodiazepine sedative-hypnotic, was involved in the death of a 39-year-old obese male who was being treated for depression and insomnia.

death

a 39-year-old obese male

Zolpidem (Ambien)

death

involved


Input: A MEDLINE search identified all the reported cases of hypersensitivity reactions to cyclosporine.

hypersensitivity reactions

cyclosporine

reactions


Input: METHODS: A 79-year-old woman being treated with imiquimod 5 days per week for a nodular basal cell developed a verrucous plaque over the treatment area after 7 weeks of therapy.

A 79-year-old woman

imiquimod 5 days per week

after 7 weeks

verrucous plaque

developed


Input: Oxcarbazepine, a metabolite of carbamazepine, is used as an antiepileptic, analgesic for neuropathic pain and in the treatment of affective disorders.

Oxcarbazepine

antiepileptic, analgesic

used


Input: PATIENT AND METHOD: A 34-year-old woman with chronic hepatitis C, genotype 3, receiving pegylated interferon alpha-2a and ribavirin for 6 months, developed progressive malaise and anemia 6 months after the end of treatment.

A 34-year-old woman with chronic hepatitis C, genotype 3

pegylated interferon alpha-2a and ribavirin for 6 months

progressive malaise and anemia

developed


Input: We report on three cases wherein treatment of dexmedetomidine-induced bradycardia with i.v.

treatment of dexmedetomidine

bradycardia with i.v

induced


Input: Esmolol, an ultrashort-acting beta 1-selective antagonist, controlled her multiple dysrhythmias and symptoms of sympathetic nervous system hyperstimulation.

Esmolol, an ultrashort-acting beta 1-selective antagonist

her

controlled


Input: (Case 1) A 29-year-old woman with overdose of metaxalone presented to the emergency department with altered mental status, seizure-like activity, hyperthermia, rigidity in the lower extremities, myoclonus, and hyperreflexia.

A 29-year-old woman

metaxalone

altered mental status, seizure-like activity, hyperthermia, rigidity in the lower extremities, myoclonus, and hyperreflexia

presented


Input: Warfarin and boceprevir interaction causing subtherapeutic international normalized ratio: a case report.

Warfarin

boceprevir

subtherapeutic international normalized ratio

causing


Input: A brief review of reported cases of chloramphenicol hypersensitivity in the English-language literature, as well as possible alternative explanations in this case, are provided.

chloramphenicol

hypersensitivity

of


Input: Possible recurrence of amiodarone pulmonary toxicity following corticosteroid therapy.

amiodarone pulmonary toxicity

corticosteroid

Possible

following


Input: In the present study, arsenic trioxide was given intravenously for 42 days to a 56-year-old female patient suffering from chemotherapy/ATRA-resistant APL, with 43% APL blasts in the bone marrow and elevated D-dimers.

56-year-old female patient

arsenic trioxide

given


Input: We assume that rIFN-gamma induced the de novo development of SLE in our patient.

rIFN-gamma

the de novo development of SLE

our patient

assume

induced


Input: Interstitial pneumopathy and low-dosage amiodarone.

low-dosage amiodarone

Interstitial pneumopathy

and


Input: CONCLUSIONS: These results suggest that clozapine may cause TD; however, the prevalence is low and the severity is relatively mild, with no or mild self-reported discomfort.

TD

clozapine

may

mild

cause


Input: Hepatotoxicity resolved once erlotinib was discontinued and serum transaminases returned to baseline normal values.

Hepatotoxicity

erlotinib

discontinued


Input: CONCLUSIONS: Sustained-release verapamil is thought to be the cause of the asthma attack in this patient because she was not taking any other preparations; the symptoms started with the administration of sustained-release verapamil and were relieved after its discontinuation.

Sustained-release verapamil

asthma attack

cause


Input: A patient developed cholestatic hepatitis while being treated with nitrofurantoin.

cholestatic hepatitis

nitrofurantoin

developed


Input: Severe apnea in an infant exposed to lamotrigine in breast milk.

apnea

lamotrigine

an infant

Severe

in


Input: Pneumonitis, bilateral pleural effusions, echocardiographic evidence of cardiac tamponade, and positive autoantibodies developed in a 43-year-old man, who was receiving long-term sulfasalazine therapy for chronic ulcerative colitis.

a 43-year-old man

long-term sulfasalazine

Pneumonitis, bilateral pleural effusions, echocardiographic evidence of cardiac tamponade, and positive autoantibodies

developed


Input: Bone formation induced in an infant by systemic prostaglandin-E2 administration.

Bone formation

an infant

systemic prostaglandin-E2 administration

induced


Input: A high dose of cotrimoxazole induced hyperkalaemia with the elevation of serum creatinine and blood urea, and increased urinary N-acetyl glucosaminase after several days of the drug administration in these patients; one patient became unconscious.

A high dose of cotrimoxazole

after several days of the drug administration

hyperkalaemia with the elevation of serum creatinine and blood urea, and increased urinary N-acetyl glucosaminase

these patients

induced

A high dose of cotrimoxazole

after several days of the drug administration

one patient

unconscious

became


Input: Angioedema, a rare side effect of carbamazepine, involves vascular leakage in dermis and subcutis mediated by immunoglobulin E and/or bradykinins.

Angioedema

involves vascular leakage in dermis and subcutis mediated by immunoglobulin E and/or bradykinins

carbamazepine

of


Input: A diagnosis of trastuzumab-induced pneumonitis was made.

trastuzumab

pneumonitis

induced


Input: We present a case of HUS in an advanced ovarian cancer patient treated with carboplatin and gemcitabine, and described its favorable outcome after chemotherapy interruption and supportive care with a 1 year follow-up.

HUS

carboplatin and gemcitabine

treated

favorable outcome

chemotherapy interruption and supportive care with a 1 year follow-up

an advanced ovarian cancer patient

after


Input: Several such HBV reactivations were reported after combined rituximab and multiagent chemotherapy for B-cell lymphomas.

Several such HBV reactivations

combined rituximab and multiagent chemotherapy

after


Input: Thus, the eosinophilia myalgia syndrome can be associated with parenteral tryptophan administration.

eosinophilia myalgia syndrome

parenteral tryptophan

can be

associated


Input: Generalized pustular psoriasis precipitated by trazodone in the treatment of depression.

trazodone

Generalized pustular psoriasis

precipitated


Input: We report a case of Sweet's syndrome in association with sargramostim treatment following chemotherapy for acute myelogenous leukemia.

sargramostim treatment following chemotherapy

Sweet's syndrome

association


Input: This regimen could prove useful for other patients who develop hypersensitivity reactions to carboplatin and allow therapy to continue.

hypersensitivity reactions

carboplatin

patients

could

develop


Input: We present a neonate with a seizure disorder who acutely developed pupillary mydriasis secondary to lidocaine overdose.

a neonate with a seizure disorde

pupillary mydriasis

lidocaine overdose

acutely

developed


Input: Based on the Naranjo algorithm, the adverse reaction observed was probably related to the hydroxyurea treatment (score = 6); however, the hydroxyurea chemotherapy could not be discontinued because of the myeloproliferative disorder.

hydroxyurea chemotherapy

myeloproliferative disorder

probably

related


Input: Extrapyramidal side effects induced by some selective serotonin reuptake inhibitors (SSRIs), i.e. fluoxetine and sertraline, have been previously reported in patients with depression and obsessive-compulsive disorder (OCD).

Extrapyramidal side effects

some selective serotonin reuptake inhibitors (SSRIs), i.e. fluoxetine and sertraline

patients with depression and obsessive-compulsive disorder (OCD)

induced by


Input: Ten-17 days after receiving chemotherapy, five patients (4 males and 1 female) with acute lymphoblastic leukemia developed incapacitating myalgias in neck, thighs and arms.

five patients (4 males and 1 female) with acute lymphoblastic leukemia

incapacitating myalgias in neck, thighs and arms

Ten-17 days after receiving chemotherapy

developed


Input: We report a case of a potential drug-drug interaction in a woman treated by a first injection of high-dose methotrexate for a T-lymphoblastic lymphoma.

a woman

a first injection of high-dose methotrexate

potential

treated


Input: We conclude that myocardial infarction may develop in patients treated with high-dose glucocorticoids for Graves' ophthalmopathy, and increased blood pressure may herald this complication.

myocardial infarction

increased blood pressure

patients

high-dose glucocorticoids

may

develop


Input: A 40-year-old man with relapsing-remitting multiple sclerosis (MS) developed primary central nervous system lymphoma (PCNSL) after having received 21 doses of natalizumab monotherapy.

primary central nervous system lymphoma (PCNSL)

21 doses of natalizumab monotherapy

40-year-old man with relapsing-remitting multiple sclerosis (MS)

developed


Input: Serotonin syndrome caused by selective serotonin reuptake-inhibitors-metoclopramide interaction.

selective serotonin reuptake-inhibitors-metoclopramide interaction

Serotonin syndrome

caused


Input: This is the first reported case of suspected DIAN due to cefuroxime.

DIAN

cefuroxime

first reported case

suspected

due to


Input: We report a cae of paranoid psychosis following use of a decongestant containing PPA and summarize the case report literature of psychiatric adverse effects to PPA in which doses were known and stated to be within recommended guidelines.

a cae

decongestant containing PPA

paranoid psychosis

following


Input: Liver transplantation for fulminant hepatitis related to nevirapine therapy.

Liver transplantation for fulminant hepatitis

nevirapine therapy

related


Input: OBJECTIVE: To report a case of fatal hyperkalemia owing to succinylcholine administration in a patient with mucositis secondary to chemotherapy.

a patient with mucositis secondary to chemotherapy

succinylcholine administration

hyperkalemia

fatal

owing

chemotherapy

mucositis

a patient

secondary


Input: We describe a case of prolonged terbinafine-induced cholestatic liver disease.

prolonged terbinafine

a case

cholestatic liver disease

induced


Input: We describe a case of interstitial hypoxaemiant pneumonitis probably related to flecainide in a patient with the LEOPARD syndrome, a rare congenital disorder.

interstitial hypoxaemiant pneumonitis

flecainide

a patient with the LEOPARD syndrome

probably

related


Input: This case showed sequential manifestation from transient thyrotoxicosis to the appearance of TSH-receptor autoantibodies, and then the occurrence of Graves' hyperthyroidism during IFN therapy.

Graves' hyperthyroidism

IFN therapy

This case

occurrence


Input: Halothane hepatitis and prompt resolution with methionine therapy: case report.

methionine

case

resolution


Input: This report describes an unexpected drug-induced hepatitis in a previously healthy young woman exposed to 2 doses of amodiaquine and artesunate.

hepatitis

a previously healthy young woman

2 doses of amodiaquine and artesunate

unexpected

exposed


Input: It was restarted 6 weeks later, and 10 weeks after that, the patient presented with fulminant hepatic failure, which resolved rapidly after cessation of nicotinic acid therapy.

fulminant hepatic failure

10 weeks after

nicotinic acid

the patient

presented


Input: We describe a patient with the antiphospholipid syndrome who had skin necrosis develop from low-molecular weight heparin therapy at sites distant from injection sites.

skin necrosis

low-molecular weight heparin therapy at sites distant from injection sites

a patient with the antiphospholipid syndrome

develop


Input: While CYP form induction by Pyrethrins, Phenobarbital and related compounds can be associated with liver and thyroid gland tumour formation in rodents, epidemiological data for Phenobarbital suggests that such effects do not occur in humans.

Pyrethrins, Phenobarbital and related compounds

liver and thyroid gland tumour formation in rodents

do not occur

induction


Input: Disulfiram encephalopathy as a cause of the catatonia syndrome.

Disulfiram

catatonia syndrome

encephalopathy

cause


Input: Little has been studied of the adverse effects of the exposure of the liver to the interaction of ethanol with its congeners and acetaldehyde, coexisting in the contents of alcoholic beverages.

adverse effects of the exposure of the liver

ethanol with its congeners and acetaldehyde

interaction


Input: Fatal serotonin syndrome precipitated by oxcarbazepine in a patient using an selective serotonin reuptake inhibitor.

serotonin syndrome

oxcarbazepine

a patient

Fatal

precipitated


Input: This eruption emerged after 1 month of therapy with salsalate, persisted for as long as salsalate was administered, and cleared within 3 weeks of discontinuing the medication.

eruption

after 1 month of therapy with salsalate

emerged


Input: A case report is presented concerning the administration of ketanserin in the treatment of pulmonary vasoconstriction and right ventricular failure following the infusion of protamine in a patient undergoing coronary artery bypass surgery and mitral valve replacement.

infusion of protamine

undergoing coronary artery bypass surgery and mitral valve replacement

a patient

pulmonary vasoconstriction and right ventricular failure

following


Input: When cyanamide-treated alcoholics relapse into drinking, more severe inflammation develops in the liver.

cyanamide

inflammation

cyanamide-treated alcoholics

severe

develops


Input: Acute renal failure should be recognized as a potential complication of suramin treatment.

Acute renal failure

suramin treatment

potential

complication


Input: After induction of general anesthesia and administration of a standard dose of intravenous esmolol hydrochloride, her cardiac rhythm progressed to asystole.

induction of general anesthesia and administration of a standard dose of intravenous esmolol hydrochloride

her

asystole

After


Input: Exacerbation of schizophrenia associated with amantadine.

amantadine

Exacerbation of schizophrenia

associated


Input: Priapism as a complication of heparin therapy.

Priapism

heparin

complication


Input: Torsades de pointes occurring in association with terfenadine use.

Torsades de pointes

terfenadine

association


Input: Protamine allergy as a complication of insulin hypersensitivity: A case report.

insulin

hypersensitivity

Protamine allergy

complication


Input: We report a case of recurrent torsades de pointes following treatment with pentavalent antimonial drugs and amiodarone.

pentavalent antimonial drugs and amiodarone

recurrent torsades de pointes

treatment with


Input: This case presentation is of a patient who had the clinical appearance of epiglottitis, but actually had an oro-pharyngeal dystonic reaction to prochlorperazine.

a patient

prochlorperazine

clinical appearance of epiglottitis

actually had an oro-pharyngeal dystonic reaction

had


Input: Localized dyskeratotic plaque with milia associated with sorafenib.

sorafenib

Localized dyskeratotic plaque with milia

associated


Input: The authors describe a case of the catatonia syndrome associated with disulfiram therapy.

catatonia syndrome

disulfiram therapy

associated


Input: Most of the clinical data on the safety profile of desmopressin (DDAVP), which is an effective treatment for both polyuric conditions and bleeding disorders, originate from studies on the tailoring of drug treatment, whereas few reports exist describing severe side effects secondary to drug-drug interaction.

desmopressin (DDAVP)

both polyuric conditions and bleeding disorders

treatment


Input: Propafenone's distribution, clearance, and structural similarity to propranolol contribute to its central nervous system effects.

Propafenone

central nervous system effects

contribute


Input: Risk of severe serotonin toxicity following co-administration of methylene blue and serotonin reuptake inhibitors: an update on a case report of post-operative delirium.

serotonin toxicity

post-operative delirium

co-administration of methylene blue and serotonin reuptake inhibitors

following


Input: Cyclophosphamide-induced cardiotoxicity occurred, even though the patient had both shown normal cardiac function before high-dose chemotherapy and had received a lower dose of cyclophosphamide.

Cyclophosphamide

high-dose chemotherapy and had received a lower dose of cyclophosphamide

cardiotoxicity

the patient had both shown normal cardiac function

induced


Input: A 64 year old woman with previous history of coronary stenting five days before was admitted in our institution for intracranial bleeding while receiving aspirin and clopidogrel.

A 64 year old woman with previous history of coronary stenting

intracranial bleeding

five days before

aspirin and clopidogrel

receiving


Input: METHODS: A case is presented of a 45-year-old woman on prolonged gemcitabine treatment for ovarian cancer who developed HUS and recovered after drug discontinuation.

a 45-year-old woman

prolonged gemcitabine treatment

HUS

developed


Input: A more serious development of adrenal insufficiency may occur upon the improper replacement of systemic steroids.

development of adrenal insufficiency

systemic steroids

may

replacement


Input: We describe a case of pneumonitis following local administration of methotrexate for nonsurgical termination of an ectopic pregnancy.

a case

pneumonitis

local administration of methotrexate

following


Input: There is currently no consensus on the best treatment for unresectable hyaline-vascular variant or for multicentric Castleman's disease (MCD), because none of the reported regimens have consistently produced complete response or durable remission in the majority of patients In the present study, we report on the use of 2-CdA (2-chloro-deoxyadenosine) in three patients, two of them with MCD and one with unresectable hyaline-vascular type disease.

one

use

2-CdA (2-chloro-deoxyadenosine)

2-CdA (2-chloro-deoxyadenosine)

two

use


Input: Carbamazepine-induced hyperammonemia.

Carbamazepine

hyperammonemia

induced


Input: Case 3: A 29-year-old female alcoholic complained of general fatigue and a slight fever after 1.5 years of abstinence with cyanamide treatment.

A 29-year-old female alcoholic

general fatigue and a slight fever

after 1.5 years of abstinence with cyanamide

slight

complained


Input: Caution is, therefore, needed to prevent undesired accumulation of TCA that may lead to protracted Cushing's syndrome.

TCA

protracted Cushing's syndrome

lead to


Input: Unusual pigmentary changes associated with 5-fluorouracil therapy.

Unusual pigmentary changes

associated


Input: Syndrome of inappropriate antidiuretic hormone associated with vinorelbine therapy.

Syndrome of inappropriate antidiuretic hormone

vinorelbine

associated


Input: The study showed a high incidence of adverse events when a higher than standard dose of the new lopinavir/ritonavir tablets was combined with rifampicin.

higher than standard dose of the new lopinavir/ritonavir tablets was combined with rifampicin

adverse events

when


Input: Onset of male gynaecomastia in a patient treated with sunitinib for metastatic renal cell carcinoma.

gynaecomastia

male

a patient

sunitinib for metastatic renal cell carcinoma

Onset


Input: Systemic disease, most commonly renal dysfunction, preceded all 30 reported cases of acyclovir neurotoxicity.

acyclovir

Systemic disease, most commonly renal dysfunction

neurotoxicity

30 reported cases

preceded


Input: Rifampicin-induced renal failure.

Rifampicin

renal failure

induced


Input: A case of high-grade endometrial stromal sarcoma, confined into an intrauterine polypoid growth, in a woman with a history of breast cancer who was treated with adjuvant tamoxifen.

adjuvant tamoxifen

A case of high-grade endometrial stromal sarcoma, confined into an intrauterine polypoid growth, in a woman with a history of breast cancer

treated


Input: After therapy for diabetic coma with insulin (containing the preservative cresol) and electrolyte solutions was started, the patient complained of increasing myalgia, developed a high fever and respiratory and metabolic acidosis and lost consciousness.

the patient

therapy for diabetic coma with insulin (containing the preservative cresol) and electrolyte solutions

increasing myalgia, developed a high fever and respiratory and metabolic acidosis and lost consciousness

After


Input: A case of severe aplastic anemia secondary to treatment with lenalidomide for multiple myeloma.

severe aplastic anemia

A case

lenalidomide for multiple myeloma

severe

secondary


Input: Seven weeks after the initiation of inhaled fluticasone, she developed vaginal candidiasis and was prescribed fluconazole 100 mg/day, a CYP3A4 inhibitor.

Seven weeks after the initiation of inhaled fluticasone

vaginal candidiasis

developed

fluconazole 100 mg/day, a CYP3A4 inhibitor

prescribed


Input: The introduction of para-aminosalicylic acid (PAS) led to hypoglycaemic coma.

The introduction of para-aminosalicylic acid (PAS)

hypoglycaemic coma

led to


Input: The risk of developing sAML is estimated to be between 1% and 5%, 2-20 years after exposure to etoposide but may also be related to cumulative drug doses, treatment schedules, host factors and co-administration of other antineoplastic agents.

sAML

2-20 years after exposure to etoposide

may

after


Input: An infant girl with choanal atresia, athelia, minor anomalies, and mild to moderate mental retardation was born to a woman treated for hyperthyroidism throughout pregnancy with methimazole and propranolol.

methimazole and propranolo

An infant girl with choanal atresia, athelia, minor anomalies, and mild to moderate mental retardation

a woman

with


Input: Ethambutol is frequently used in the treatment of tuberculosis, and, although optic neuropathies have been reported with the use of ethambutol, this adverse side effect has been considered to be rare and generally reversible with discontinuation of the medication.

Ethambutol

used


Input: Skin manifestations of a case of phenylbutazone-induced serum sickness-like reactions.

phenylbutazone

serum sickness-like reactions

induced


Input: Development of Crohn's disease in a patient with multiple sclerosis treated with copaxone.

copaxone

Crohn's disease

a patient with multiple sclerosis

Development


Input: Aliskiren-associated acute renal failure with hyperkalemia.

Aliskiren

acute renal failure

associated


Input: Fever caused by the use of furosemide was proved; the fever resolved after discontinuation of this medication and recurred after its reintroduction.

Fever

furosemide

caused


Input: The use of methotrexate (MTX) has been contraindicated for treatment of severe psoriasis in HIV infection on the basis of six previously reported cases in which MTX appeared to potentiate opportunistic infections and accelerate HIV disease.

MTX

HIV disease

accelerate


Input: Pharmacokinetics of dapsone gel, 5% for the treatment of acne vulgaris.

dapsone gel, 5%

treatment


Input: To our knowledge, these cases represent the first reports of TDF-associated irreversible renal failure and rickets in pediatric patients.

TDF

irreversible renal failure and rickets

pediatric patients

associated


Input: In particular, this adverse effect has never been described with mefloquine (Lariam).

mefloquine (Lariam)

adverse effect

never

described


Input: A potential role for renal and hepatic impairment in the observed protracted course of amiodarone-induced thyrotoxicosis is suggested.

amiodarone

thyrotoxicosis

potential

induced


Input: The patient completed a 10-month follow-up, maintaining a complete resolution of the treated skin lesions; however, the development of a painful hand ulcer, possibly associated with the hydroxyurea, and new skin cancers were observed at the last follow-up visit.

The patient

a painful hand ulcer

new skin cancers

hydroxyurea

possibly

associated


Input: Potential aripiprazole-mediated extrapyramidal symptoms in an adult with developmental disabilities.

aripiprazole

extrapyramidal symptoms

an adult with developmental disabilities

mediated


Input: We describe a patient with extranodal non-Hodgkin lymphoma who developed systemic candidiasis after treatment with a cyclophosphamide-based chemotherapy regimen.

a patient with extranodal non-Hodgkin lymphoma

systemic candidiasis

a cyclophosphamide-based chemotherapy regimen.

treatment


Input: We describe the first case of de novo asthma following treatment with the angiotensin converting enzyme (ACE) inhibitor captopril.

de novo asthma

the angiotensin converting enzyme (ACE) inhibitor captopril

treatment with


Input: A 53-year-old male, without any prior history of psychosis, developed schizophrenia 4 days after starting low-dose bromocriptine therapy for a macroprolactinoma.

A 53-year-old male, without any prior history of psychosis

macroprolactinoma

schizophrenia

4 days after starting low-dose bromocriptine therapy

developed


Input: Six days after taking erlotinib, a chest radiograph showed rapid progression of reticular infiltration in both lung fields.

rapid progression of reticular infiltration in both lung fields

Six days

erlotinib

after


Input: Because of suspected drug-induced seizures, both antidepressants were stopped.

antidepressants

seizures

suspected

stopped


Input: Based on the Naranjo probability scale, serotonin syndrome was a probable adverse reaction associated with co-administration of citalopram and fentanyl.

serotonin syndrome

co-administration of citalopram and fentanyl

probable

associated


Input: We report a case of a patient with rheumatoid arthritis treated with low-dose methotrexate (15 mg/week) who developed infection with both M. tuberculosis and M. chelonae after the revision of a prosthetic hip.

patient with rheumatoid arthritis

low-dose methotrexate (15 mg/week)

nfection with both M. tuberculosis and M. chelonae

developed


Input: Thrombotic microangiopathy with renal failure in two patients undergoing gemcitabine chemotherapy.

gemcitabine chemotherapy

Thrombotic microangiopathy with renal failure

two patients

undergoing


Input: Despite the known pulmonary side effects of nitrofurantoin, there is no report of this toxicity occurring in pregnant patients.

pulmonary side effects

nitrofurantoin

no

of


Input: However, several case reports have suggested that clozapine could also cause TD.

TD

clozapine

cause


Input: A case is presented in which a 68-year-old man became delirious after being withdrawn from a low dosage of alprazolam.

68-year-old man

withdrawn from a low dosage of alprazolam

delirious

after


Input: However, re-initiation of sunitinib treatment was followed by bilateral breast enlargement again.

sunitinib

bilateral breast enlargement

followed


Input: BACKGROUND: Hydroxyurea is a cytostatic agent used to treat myeloproliferative disorders and long-term treatment is associated with mucocutaneous adverse events and nail hyperpigmentation.

Hydroxyurea is a cytostatic agen

mucocutaneous adverse events and nail hyperpigmentation

associated


Input: Captopril-induced acute reversible renal failure.

Captopril

acute reversible renal failure

induced


Input: Hence, hyperthyroidism induced by IFN-alpha could correspond to the first phase of silent thyroiditis, to Graves' disease or to the succession of both.

IFN-alpha

hyperthyroidism

induced


Input: The epivodes of NMS occured under treatment with clozapine, risperidone, and amisulpride.

NMS

clozapine, risperidone, and amisulpride

occured


Input: During the first days of arsenic trioxide treatment a rapid decrease in the D-dimers was seen (normal values reached until day 7), together with a slight decrease in peripheral blood leukocytes.

the first days of arsenic trioxide treatment

a rapid decrease in the D-dimers was seen (normal values reached until day 7), together with a slight decrease in peripheral blood leukocytes

During


Input: In contrast to chronic or subacute thyroiditis, Graves' disease rarely complicates IFN-alpha therapy for chronic viral C hepatitis.

IFN-alpha

Graves' disease

for


Input: We postulate that gastritis caused by dexamethasone, mucositis caused by doxorubicin, and the unique anatomic nature of a Meckel diverticulum may have contributed to this extremely unlikely and previously unreported event.

gastritis

dexamethasone

may

caused

mucositis

doxorubicin

caused


Input: Mesalamine may cause hypersensitivity pneumonitis in patients with Crohn's disease.

Mesalamine

hypersensitivity pneumonitis

patients with Crohn's disease

may

cause


Input: We present a case in which dipyridamole induced high-grade atrioventricular (AV) block that responded promptly to intravenous aminophylline but not to atropine.

dipyridamole

high-grade atrioventricular (AV) block

induced

intravenous aminophylline but not to atropine

responded


Input: This paper reports an autopsy case of a 78-year-old male with multiple nodules in the liver developed after long-termed administration of phosphate diethylstilbestrol (PDES) for prostatic cancer.

an autopsy case of a 78-year-old male

prostatic cancer

multiple nodules in the liver

phosphate diethylstilbestrol (PDES)

developed


Input: Fracture of the femoral neck occurred in one patient during PSL therapy, although the relationship between the fracture and PSL therapy was uncertain.

Fracture of the femoral neck

one patient

PSL therapy

uncertain

occurred


Input: This panic anxiety was not relieved by taking etizolam and flunitrazepam again, but subsided rapidly by the re-administration of mianserin 30 mg/day, and because of that the depressive symptom also disappeared.

etizolam and flunitrazepam

mianserin 30 mg/day

because of that the depressive symptom also disappeared

subsided


Input: When co-trimoxazole was stopped the red cell aplasia resolved.

co-trimoxazole

red cell aplasia resolved

stopped


Input: Interaction of sildenafil and indinavir when co-administered to HIV-positive patients.

HIV-positive patients

Interaction of sildenafil and indinavir

co-administered


Input: Cerebral and ocular toxicity induced by desferrioxamine.

Cerebral and ocular toxicity

desferrioxamine

induced


Input: A patient developed papilloedema and hepatic dysfunction while being treated with perhexiline maleate.

perhexiline maleate

A patient

papilloedema and hepatic dysfunction

while


Input: We describe a case of subcutaneous metastasis along the needle track after percutaneous ethanol injection (PEI) for treatment of hepatocellular carcinoma.

subcutaneous metastasis

percutaneous ethanol injection (PEI)

a case

after


Input: He developed episodic movements possibly consistent with EPS secondary to aripiprazole usage.

episodic movements possibly consistent with EPS

secondary to aripiprazole usage

developed


Input: Recently, it has been reported that terfenadine and astemizole, which have antiallergic actions similar to those of oxatomide, show side effects on the cardiovascular system, such as QT prolongation, ventricular arrhythmia and cardiac arrest.

terfenadine and astemizole

side effects on the cardiovascular system, such as QT prolongation, ventricular arrhythmia and cardiac arrest

show


Input: We reported 3 patients who developed acute generalized dystonia and akinetic rigid syndrome following an initial therapy with d-penicillamine 125-500 mg daily.

d-penicillamine 125-500 mg daily

3 patients

acute generalized dystonia and akinetic rigid syndrome

following


Input: Priapism associated with olanzapine.

Priapism

olanzapine

associated


Input: Thus, an immunological mechanism might be involved in the mechanism of pirmenol-induced QT prolongation and T wave inversion on the electrocardiogram.

pirmenol

QT prolongation and T wave inversion

might be involved

induced


Input: Five months after initiating mirtazapine therapy, she developed symptomatic hyponatremia.

symptomatic hyponatremia

Five months after initiating mirtazapine

she

developed


Input: Intravenous verapamil therapy in babies may cause apnea, hypotension, and bradycardia; continued episodes of atrial flutter in a child may cause sudden death; quinidine may be related to the death; children with "familial seizure disorders" may in fact have the long QT interval syndrome.

Intravenous verapamil

babies

apnea, hypotension, and bradycardia

may

cause

quinidine

death

may

related


Input: The renal biopsy showed focal segmental glomerulosclerosis, which has only been previously reported in two cases of CML treated with IFNalpha.

The renal biopsy showed focal segmental glomerulosclerosis

two cases

IFNalpha

reported


Input: Sulindac (Clinoril), a nonsteroidal anti-inflammatory agent, has few reported neurologic toxic effects, all of which have been associated with systemic disease.

neurologic toxic effects

Sulindac (Clinoril)

reported


Input: The second patient was a 32-year-old woman with HIV, anxiety disorder, and a history of intravenous drug abuse who developed increased sedation and mental confusion when an atazanavir-ritonavir-based antiretroviral regimen was added to her stable antianxiety drug regimen, which included quetiapine.

a 32-year-old woman with HIV, anxiety disorder, and a history of intravenous drug abuse

increased sedation and mental confusion

atazanavir-ritonavir-based antiretroviral regimen was added to her stable antianxiety drug regimen, which included quetiapine

developed


Input: Fulminant hepatitis associated with disulfiram.

disulfiram

Fulminant hepatitis

associated


Input: Anhedonic ejaculation with desipramine.

Anhedonic ejaculation

desipramine

with


Input: Serotonin syndrome induced by transitioning from phenelzine to venlafaxine: four patient reports.

Serotonin syndrome

phenelzine to venlafaxine

four patient

induced


Input: Lower extremity arterial thrombosis following sonographically guided thrombin injection of a femoral pseudoaneurysm.

Lower extremity arterial thrombosis

thrombin injection of a femoral pseudoaneurysm

following


Input: A severe form of exophthalmos resulting from lithium therapy has not been described in the literature.

exophthalmos

lithium

severe

resulting


Input: No cases of renal acidosis, and only one case of nephrogenic diabetes insipidus, has been previously reported as a complication of foscarnet treatment.

nephrogenic diabetes insipidus

foscarnet treatment

reported


Input: Cough induced by quinapril with resolution after changing to fosinopril.

Cough

fosinopril

resolution


Input: INTRODUCTION: Although gefitinib used for the treatment of non-small-cell lung cancer is a well-known cause of interstitial lung disease (ILD), few case reports on erlotinib-induced ILD have been issued.

gefitinib

interstitial lung disease (ILD)

cause

erlotinib

ILD

induced


Input: We report a case in which a potential drug interaction resulted in elevated phenytoin levels after initiation of erlotinib therapy in a patient who was receiving phenytoin.

a potential drug interaction

initiation of erlotinib therapy

receiving phenytoin

elevated phenytoin levels

a patient

potential

resulted in


Input: Anastrozole-associated sclerosing glomerulonephritis in a patient with breast cancer.

a patient with breast cancer.

Anastrozole

sclerosing glomerulonephritis

associated


Input: BACKGROUND: Gemcitabine has mild renal toxicity, but cases of gemcitabine-associated hemolytic-uremic syndrome (HUS) have been reported.

gemcitabine

hemolytic-uremic syndrome (HUS)

renal toxicity

cases

mild

associated


Input: Recurrent palmar-plantar erythrodysaesthesia following high-dose cytarabine treatment for acute lymphoblastic leukemia.

palmar-plantar erythrodysaesthesia

high-dose cytarabine

treatment


Input: CONCLUSIONS: Peripheral administration of low-dose vasopressin for septic shock should be discouraged because of the risk of ischemic skin complications.

ischemic skin complications

Peripheral administration of low-dose vasopressin

risk

risk


Input: Many types of medicaments can cause akathisia as an adverse event of their use and they include: antipsychotics, antidepressants, antiemetics, antihistamines, and psychoactive substances.

antipsychotics, antidepressants, antiemetics, antihistamines, and psychoactive substances

akathisia

adverse event


Input: We report the case of a 60-year-old woman who developed erythema and erosions in the axilla and groin while on PLD for breast cancer.

a 60-year-old woman

breast cancer

erythema

erosions in the axilla and groin

PLD

developed


Input: Serotonin syndrome has been reported with administration of linezolid and serotonin reuptake inhibitors.

administration of linezolid and serotonin reuptake inhibitors

Serotonin syndrome

reported with


Input: We suggest that the treatment of hypoglycaemia with 50% solution of dextrose is associated with a significant risk factor in those diabetic individuals who are either allergic or are receiving beta-adrenoreceptor blocking drugs.

50% solution of dextrose

diabetic individuals who are either allergic or are receiving beta-adrenoreceptor blocking drugs

a significant risk factor

associated


Input: A case of phenobarbital exacerbation of a preexisting maladaptive behavior partially suppressed by chlorpromazine and misinterpreted as chlorpromazine efficacy.

phenobarbital

partially suppressed by chlorpromazine

exacerbation of a preexisting maladaptive behavior

preexisting maladaptive behavior

exacerbation


Input: Colchicine-induced myopathy in a teenager with familial Mediterranean fever.

Colchicine

myopathy

a teenager with familial Mediterranean fever

induced


Input: Levofloxacin-induced delirium with psychotic features.

delirium with psychotic features

Levofloxacin

induced


Input: Methemoglobinemia: an occupational hazard of phenylpropanolamine production.

Methemoglobinemia

phenylpropanolamine

production


Input: Destructive thyrotoxicosis appeared 4-6 months after starting IFN-alpha, followed by Graves' hyperthyroidism within 8 to 11 months.

Destructive thyrotoxicosis

Graves' hyperthyroidism

IFN-alpha

after


Input: CASE SUMMARIES: In each case, the patients were treated over 5 years with lovastatin and developed rhabdomyolysis that coincided with the completion of a prescribed regimen of a newer macrolide antibiotic.

patients

5 years with lovastatin

a newer macrolide antibiotic

rhabdomyolysis

developed


Input: Thrombotic stroke associated with the use of porcine factor VIII in a patient with acquired haemophilia.

patient with acquired haemophilia

Thrombotic stroke

porcine factor VIII

associated


Input: PURPOSE: The intravitreal application of triamcinolone acetonide as treatment of long-standing, therapy-resistant cystoid macular edema after penetrating keratoplasty is reported.

The intravitreal application of triamcinolone acetonide

treatment


Input: Patients receiving ciprofloxacin and digoxin should be monitored closely for the risk of digoxin toxicity.

Patients

ciprofloxacin and digoxin

digoxin toxicity

should

the risk


Input: To our knowledge this is the first report of pancytopenia due to MMI, where the usual hypoplasia found is replaced by massive plasmocytosis.

pancytopenia

MMI

due


Input: The following is a report of 2 cases of rifampicin-induced renal insufficiency.

rifampicin

renal insufficiency

induced


Input: Fatal eosinophilia myalgia syndrome in a marrow transplant patient attributed to total parenteral nutrition with a solution containing tryptophan.

Fatal eosinophilia myalgia syndrome

marrow transplant patient

total parenteral nutrition with a solution containing tryptophan

attributed


Input: We describe a 43-year-old man who developed signs and symptoms of bilateral optic neuropathy during treatment with ethambutol.

43-year-old man

bilateral optic neuropathy

ethambutol

developed


Input: The patient described in this paper was a 78-year-old diabetic man who developed oral lesions of PV following institution of glibenclamide therapy.

institution of glibenclamide

The patient described in this paper was a 78-year-old diabetic man

oral lesions of PV

following


Input: Since elevated cortisol levels in Cushing's disease poses a threat for pancreatitis, there is a possibility that patients with Cushing's disease might be more prone to acute pancreatitis following propofol administration.

acute pancreatitis

propofol

patients with Cushing's disease

might

following


Input: Ticlopidine is an oral antiplatelet agent frequently utilized in the treatment of cerebrovascular disease and is rarely associated with severe bone marrow suppression, typically aplastic anemia.

Ticlopidine is an oral antiplatelet agent

severe bone marrow suppression, typically aplastic anemia

rarely

associated


Input: Moxifloxacin and lomefloxacin are fluoroquinolone antibiotics used in treating urinary and respiratory tract infections.

Moxifloxacin and lomefloxacin

fluoroquinolone antibiotics

treating


Input: To our knowledge, this case report represents only the third description of laxative-induced TEN.

laxative

TEN

induced


Input: Prompted by the advent of potentially life-threatening neuromuscular symptoms following initiation of linezolid therapy in two patients receiving treatment with a serotonin reuptake inhibitor antidepressant, an evaluation was conducted to determine the incidence and characteristics of symptomatic serotonin toxicity among hospitalized patients receiving combined treatment with these medications.

linezolid

with a serotonin reuptake inhibitor antidepressant

life-threatening neuromuscular symptoms

two patients

life-threatening

following


Input: Celiac disease onset after pegylated interferon and ribavirin treatment of chronic hepatitis C.

pegylated interferon and ribavirin treatment of chronic hepatitis C

Celiac disease

onset


Input: Hyperkalaemia with renal tubular dysfunction by sulfamethoxazole-trimethoprim for Pneumocystis carinii pneumonia in patients with lymphoid malignancy.

patients with lymphoid malignancy

Hyperkalaemia with renal tubular dysfunction

sulfamethoxazole-trimethoprim for Pneumocystis carinii pneumonia

by


Input: Following 7 days of tigecycline she developed severe abdominal pain and elevated pancreatic enzymes suggesting acute pancreatitis.

7 days of tigecycline

abdominal pain and elevated pancreatic enzymes

she

severe

developed


Input: To treat hepatitis B, interferon alpha was administered until the proximal muscle weakness developed.

interferon alpha

proximal muscle weakness

developed


Input: We report a case of the serotonin syndrome during treatment with lithium and venlafaxine, an antidepressant with a dual selective re-uptake inhibition mechanism, and review the literature for similar cases.

serotonin syndrome

lithium and venlafaxine

a case

during


Input: Supratherapeutic flecainide plasma concentrations may cause delirium.

delirium

Supratherapeutic flecainide plasma concentrations

cause


Input: At the end of his fifth cycle of sunitinib therapy, the patient complained of the development of abnormally large mammary glands associated with pain and peri-areolar erythema.

fifth cycle of sunitinib therapy

the patient

abnormally large mammary glands associated with pain and peri-areolar erythema

development


Input: This is a case report of possible association of methylphenidate and enuresis in an 11-year-old boy with attention deficit hyperactivity disorder.

methylphenidate

enuresis

an 11-year-old boy with attention deficit hyperactivity disorder

possible

association


Input: This report describes a case of neuroleptic malignant syndrome due to risperidone in a child with Joubert syndrome.

a child with Joubert syndrome

risperidone

neuroleptic malignant syndrome

due to


Input: A 47-year-old HIV-infected man with dilated cardiomyopathy and prolonged QT syndrome with an automatic implantable cardiovascular defibrillator device was prescribed subcutaneous enfuvirtide 90 mg twice daily as part of his antiretroviral regimen and oral extended-release niacin 500 mg/day for a high-density lipoprotein level of 8 mg/dL. After 1 week of concomitant therapy, the patient began experiencing extreme redness, edema, and swelling at the injection site that corresponded with the flushing sensation due to niacin.

A 47-year-old HIV-infected man with dilated cardiomyopathy and prolonged QT syndrome with an automatic implantable cardiovascular defibrillator device

subcutaneous enfuvirtide 90 mg twice daily as part of his antiretroviral regimen and oral extended-release niacin 500 mg/day for a high-density lipoprotein level of 8 mg/dL

extreme redness, edema, and swelling at the injection site that corresponded with the flushing sensation due to niacin

experiencing


Input: Acute INH neurotoxicity was not suspected on the first admission; however, when readmitted 4 weeks later with another seizure, the diagnosis of acute INH neurotoxicity was made.

INH

seizure

acute INH neurotoxicity

diagnosis


Input: Levofloxacin-induced toxic epidermal necrolysis in an elderly patient.

an elderly patient.

Levofloxacin

toxic epidermal necrolysis

induced


Input: The incidence of 5-fluorouracil (5-FU)-related cardiotoxicity seems to be dosage and schedule dependent.

dosage

schedule

cardiotoxicity

seems

related


Input: Torsades de Pointes induced by a combination of garenoxacin and disopyramide and other cytochrome P450, family 3, subfamily A polypeptide-4-influencing drugs during hypokalemia due to licorice.

Torsades de Pointes

a combination of garenoxacin and disopyramide and other cytochrome P450, family 3, subfamily A polypeptide-4-influencing drugs

induced


Input: Ataxia caused by propafenone has been reported to the pharmaceutical companies and drug monitoring agencies, but has not been well described or emphasized in the medical literature.

propafenone

Ataxia

caused


Input: The first patient developed mild nitritoid symptoms and pain in a band-like distribution, corresponding to T10-T12 dermatomes, shortly after gold sodium thiomalate (GSTM) injection.

gold sodium thiomalate (GSTM) injection

The first patient

mild nitritoid symptoms and pain in a band-like distribution

mild

developed


Input: A case is reported of an elderly woman who developed febrile agranulocytosis several weeks after commencing ticlopidine but who had a favorable outcome after cessation of that drug and treatment with filgastrim.

an elderly woman

febrile agranulocytosis

several weeks after commencing ticlopidine

developed

an elderly woman

a favorable outcome

cessation of that drug and treatment with filgastrim

after


Input: Two 65-year-old white men with coronary heart disease, given niacin therapy for dyslipidemia for 5 months, developed intense dental and gingival pain that was associated with increases in dose and that was relieved with discontinuance of niacin treatment.

niacin therapy for dyslipidemia for 5 months

increases in dose

intense dental and gingival pain

Two 65-year-old white men with coronary heart disease

developed


Input: Two patients are described who developed testicular swelling and pain during treatment with desipramine.

desipramine

Two patients

testicular swelling and pain

during


Input: Metabolic balance studies and rechallenge with hydrochlorothiazide were undertaken to investigate the mechanism of the thiazide-induced hyponatremia.

hyponatremia

thiazide

induced


Input: Paradoxical pulmonary vasoconstriction induced by nitroglycerin in idiopathic pulmonary hypertension.

Paradoxical pulmonary vasoconstriction

nitroglycerin

induced


Input: Although visual hallucinations have not been reported as an adverse effect of this agent, we describe three patients who experienced complex visual hallucinations and altered mental status after zonisamide treatment was begun or its dosage increased.

zonisamide

complex visual hallucinations and altered mental status

after


Input: Clinical profile of oxcarbazepine-related angioneurotic edema: case report and review.

oxcarbazepine

angioneurotic edema

case

related


Input: Extra caution should be taken in using octreotide or its long-acting analog in patients otherwise predisposed to intrahepatic bile stasis.

octreotide or its long-acting analog

intrahepatic bile stasis

patients

predisposed


Input: BACKGROUND: Fluoxetine, a highly specific serotonin reuptake inhibitor, has been reported to cause sexual dysfunction in a minority of patients.

sexual dysfunction

Fluoxetine

minority of patients

cause


Input: We report a 45-year-old Chinese man with CML and chronic hepatitis B virus infection, on imatinib treatment, presenting with herpetic rash and acute liver failure.

a 45-year-old Chinese man with CML and chronic hepatitis B virus infection

on imatinib treatment

herpetic rash and acute liver failure

presenting


Input: One patient had severe temporary weakness after an ampicillin sodium challenge.

One patient

temporary weakness

an ampicillin sodium challenge

severe

after


Input: Acute myeloid leukemia and lung cancer occurring in a chronic lymphocytic leukemia patient treated with fludarabine and autologous peripheral blood stem-cell transplantation.

Acute myeloid leukemia and lung cancer

a chronic lymphocytic leukemia patient

fludarabine and autologous peripheral blood stem-cell transplantation

occurring


Input: Despite a very low complication rate, several severe arterial thrombotic events have been reported following thrombin injection of pseudoaneurysms.

arterial thrombotic

thrombin injection

severe

following


Input: The results clearly demonstrate that CPH82 was associated with suppression of the endogeneous production of ACTH and cortisol with a concomitant paradoxical picture of clinical hypercortisolism.

suppression of the endogeneous production of ACTH and cortisol with a concomitant paradoxical picture of clinical hypercortisolism

associated


Input: Exposure of the fetus to indomethacin by administration of the drug to the mother may cause many side effects, including premature closure of the ductus arteriosus.

fetus

indomethacin

premature closure of the ductus arteriosus

may

side effects


Input: She was diagnosed with Epstein-Barr virus-associated polymorphic lymphoproliferative disorder (LPD) due to immunodeficiency caused by MTX administration.

Epstein-Barr virus-associated polymorphic lymphoproliferative disorder (LPD)

immunodeficiency caused by MTX administration

She

due


Input: Pulmonary hypertension during lithium therapy: clinical case study.

lithium therapy

Pulmonary hypertension

during


Input: CONCLUSIONS: Clinicians should be aware of this adverse reaction when facing similar complex neurologic symptoms in patients who are receiving the antibiotic treatment described here, especially vancomycin.

vancomycin

patients

neurologic symptoms

adverse reaction


Input: Corneal edema recurred when the administration of amantadine was resumed.

Corneal edema

the administration of amantadine was resumed

when


Input: Vitamin K1 caused skin rash possibly because of the distribution and metabolism characteristic of the drug in this patient.

Vitamin K1

skin rash

caused


Input: Initial treatment with heparin was substituted with thrombolysis, which resulted in clinical improvement and dissolution of right heart thrombus but was followed by fatal intracerebral haemorrhage.

thrombolysis

fatal intracerebral haemorrhage

fatal

resulted


Input: The most commonly recognized toxic effect of ethambutol is optic neuropathy, which generally is considered uncommon and reversible in medical literature.

ethambutol

optic neuropathy

effect


Input: A case of congestive heart failure in a child with Wilms' tumor treated Adriamycin is presented and discussed.

congestive heart failure

a child with Wilms' tumor

Adriamycin

in


Input: BACKGROUND: Hypersensitivity reactions to cyclosporine are rare.

Hypersensitivity reactions

cyclosporine

to


Input: This is the first case of TMP-SMX-induced hypersensitivity syndrome associated with the reactivation of a latent viral infection.

TMP-SMX

hypersensitivity syndrome

reactivation of a latent viral infection

first case

induced


Input: In addition, single-agent weekly AUC2-carboplatin appeared to be inactive by response criteria in a homogenously defined population of PROC.

single-agent weekly AUC2-carboplatin

a homogenously defined population of PROC

inactive

inactive


Input: CONCLUSIONS: Intrathecal baclofen can impair sexual function and ejaculation in some patients.

Intrathecal baclofen

impair sexual function and ejaculation

some patients

impair


Input: A case of clozapine-induced tonic-clonic seizures managed with valproate: implications for clinical care.

clozapine

tonic-clonic seizures

A case

induced

A case

valproate

managed


Input: Serum sickness consists of a systemic reaction resulting from the formation of soluble circulating immunocomplexes after the introduction of a foreign substance into the body We studied a 38-year-old woman diagnosed with anxiety, depression and right sacroileitis who was treated with phenylbutazone, ranitidine, clomipramine and levomepromazine.

a 38-year-old woman diagnosed with anxiety, depression and right sacroileitis

phenylbutazone, ranitidine, clomipramine and levomepromazin

treated


Input: The symptomatology of 18 other paediatric cases of naphthylimidazoline exposure reported to the Belgian National Poison Centre, is also discussed.

18 other paediatric cases

naphthylimidazoline exposure

naphthylimidazoline

symptomatology


Input: Anterior spinal artery syndrome--a complication of cervical intrathecal phenol injection.

Anterior spinal artery syndrome

cervical intrathecal phenol injection

complication


Input: Phenytoin was discontinued after admission; however, phenytoin 1 g i.v. was given for a tonic-clonic seizure two days after admission, after which swelling of the face and legs and pruritus developed.

swelling of the face and legs and pruritus

phenytoin 1 g i.v.

developed


Input: To our knowledge this is the first report that demonstrates histological abnormalities of the glomerulus associated with postoperative IFN-beta therapy for the malignant melanoma.

histological abnormalities of the glomerulus

postoperative IFN-beta therapy

associated


Input: Protease inhibitor-induced carbamazepine toxicity.

Protease inhibitor

carbamazepine toxicity

induced


Input: This report details a case of bilateral avascular necrosis of the femoral heads in a patient receiving 'standard' doses of dexamethasone as part of the antiemetic regimen used in cisplatin-based combination chemotherapy.

bilateral avascular necrosis of the femoral heads

a patient

'standard' doses of dexamethasone

receiving


Input: He recovered successfully after treatment with very high doses of corticosteroids and azathioprine.

very high doses of corticosteroids and azathioprine

He

recovered


Input: Marked hyperkalemia was observed during and immediately after an infusion of arginine monohydrochloride in two patients with severe hepatic disease and moderate renal insufficiency.

Marked hyperkalemia

during and immediately after an infusion of arginine monohydrochloride

two patients with severe hepatic disease and moderate renal insufficiency

severe

observed


Input: Finally, reserpine toxicity, in particular central nervous system (CNS) disturbances, was reported more frequently in patients also receiving barbiturates, suggesting additive CNS effects.

reserpine toxicity, in particular central nervous system (CNS) disturbances

additive CNS effects

reserpine

also receiving barbiturates,

reported


Input: Patients receiving amifostine who develop only fever should be evaluated for an adverse drug reaction, as well as for sepsis and fevers of neutropenia, and it may be necessary to discontinue the drug.

amifostine

fever

sepsis and fevers of neutropenia

develop


Input: Clinical signs of hypermagnesemia are an uncommon complication following oral administration of magnesium sulfate.

hypermagnesemia

oral administration of magnesium sulfate

complication


Input: Markedly increased pigmementation of skin immediately overlying veins used for multiple 5-fluorouracil infusions was noted.

Markedly increased pigmementation of skin immediately overlying veins

multiple 5-fluorouracil infusions

noted


Input: Severe hepatitis caused by cyproterone acetate.

Severe hepatitis

cyproterone acetate

Severe

caused


Input: Erythema multiforme associated with phenytoin and cranial radiation therapy: a report of three patients and review of the literature.

Erythema multiforme

phenytoin and cranial radiation therapy

three patients

associated


Input: Chloroquine has been used for many decades in the prophylaxis and treatment of malaria.

Chloroquine

prophylaxis and treatment

of


Input: Before ICU admission, the patient had suffered from painful mucositis causing severe dysphagia and bleeding, which was thought to be the result of chemotherapy.

chemotherapy

severe dysphagia and bleeding

the patient had suffered from painful mucositis

result


Input: We report the case of a patient with the acquired immunodeficiency syndrome treated with rifampicin who had a 'normal' screening test for adrenal insufficiency, yet had clinical evidence of adrenal failure.

a patient with the acquired immunodeficiency syndrome

rifampicin

adrenal failure

had


Input: We postulate that cyclosporin, possibly together with ganciclovir, can produce transient brain stem or neuromuscular dysfunction with eye movement abnormality in occasional patients.

cyclosporin

together with ganciclovir

occasional patients

transient brain stem or neuromuscular dysfunction with eye movement abnormality

postulate

produce


Input: Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.

Three patients

'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment)

cytotoxic treatment, including high dose methotrexate with folinic acid rescue

resulted


Input: Methylene blue-associated serotonin toxicity has been described before but usually as mild toxicity.

Methylene blue

serotonin toxicity

mild

associated


Input: The second was an 82-year-old man receiving ticlopidine for 2 years when, during a febrile episode, he was found neutropenic with marrow aplasia.

neutropenic with marrow aplasia.

receiving ticlopidine for 2 years

82-year-old man

found


Input: INTRODUCTION: In resource limited settings patients on antiretroviral treatment who develop stavudine induced hyperlactatemia are often switched to zidovudine on the basis of published studies that demonstrate that this agent can be a safe alternative.

stavudine

hyperlactatemia

patients on antiretroviral treatment

induced

patients on antiretroviral treatment

zidovudine

switched


Input: We report a case of pediatric bupropion ingestion resulting in multiple seizures.

pediatric

bupropion ingestion

multiple seizures

resulting


Input: The co-administration of SSRIs and fentanyl may precipitate serotonin toxicity.

serotonin toxicity

co-administration of SSRIs and fentanyl

may

precipitate


Input: Three days after intravitreal injection of bevacizumab, acute ocular ischemic syndrome occurred.

Three days after intravitreal injection of bevacizumab

acute ocular ischemic syndrome

occurred


Input: After addition of lopinavir/ritonavir, eight volunteers suffered from both nausea and vomiting, one from nausea only, and one from vomiting only.

lopinavir/ritonavir

eight volunteers

nausea and vomiting

After

lopinavir/ritonavir

one

vomiting

After

lopinavir/ritonavir

one

nausea

After


Input: Calcipotriol (Daivonex R; Leo Pharmaceuticals, Zurich, Switzerland) may cause irritation of the skin, whereas allergic reactions are less common.

irritation of the skin

Calcipotriol

may

cause


Input: After discontinuation of danazol the diabetes completely resolved.

discontinuation of danazo

resolved


Input: We describe the development of ischemic colitis in a woman who was treated with tegaserod and review the relationship among ischemic colitis, tegaserod use, and irritable bowel syndrome.

woman

ischemic colitis

tegaserod

development


Input: We presented the case of a patient who developed a cutaneous reaction induced by captopril with positive patch test.

a patient

cutaneous reaction

captopril

induced


Input: Three of these patients had convulsions attributed to imipenem/cilastatin; 3.6% of the patients had seizure, or 2% of imipenem/cilastatin administrations was followed by a seizure attack.

Three of these patients

imipenem/cilastatin

convulsions

attributed

imipenem/cilastatin

seizure

followed


Input: This latest (third) report suggests that the safety profile should be reexamined and at least raises the question of potential renal toxicity of interferons in MS.

potential renal toxicity

interferons

potential

raises


Input: Co-trimoxazole red cell aplasia in leukaemia.

Co-trimoxazole

red cell aplasia

in


Input: Interferon-alpha (IFN-alpha) may precipitate or exacerbate the occurrence of MPGN.

Interferon-alpha (IFN-alpha)

MPGN

may

precipitate or exacerbate

occurrence


Input: Toxic epidermal necrolysis after the use of high-dose cytosine arabinoside.

high-dose cytosine arabinoside

Toxic epidermal necrolysis

after


Input: We describe 3 elderly patients with moderate to severe ataxia that occurred while they were taking propafenone.

moderate to severe ataxia

taking propafenone

3 elderly patients

occurred


Input: Gestational diabetes was no less severe (degree of hyperglycaemia, need for insulin therapy) when associated with norethisterone.

Gestational diabetes

norethisterone

no less severe

associated


Input: However, follow-up revealed that gestational diabetes when associated with norethisterone had a lesser risk of emerging diabetes mellitus and impaired glucose tolerance.

diabetes mellitus and impaired glucose tolerance

norethisterone

lesser risk

emerging


Input: Because the cerebellar toxicity may be worsened by continuation of therapy after initial onset of symptoms, prompt termination of HDARAC is recommended.

cerebellar toxicity

HDARAC

of


Input: We describe a case of ulcerative proctitis after ibuprofen treatment in a girl with juvenile systemic lupus erythematosus.

ibuprofen treatment

ulcerative proctitis

a girl with juvenile systemic lupus erythematosus

after


Input: Clinicians should include phenolphthalein in their list of possible causes of drug-induced TEN.

phenolphthalein

TEN

possible

induced


Input: Methotrexate-induced diffuse interstitial pulmonary fibrosis.

Methotrexate

diffuse interstitial pulmonary fibrosis

induced


Input: Abdominal wall ulceration and mucinosis secondary to recombinant human interferon-beta-1b.

Abdominal wall ulceration and mucinosis

recombinant human interferon-beta-1b

secondary


Input: Asthenozoospermia: possible association with long-term exposure to an anti-epileptic drug of carbamazepine.

Asthenozoospermia

long-term exposure to an anti-epileptic drug of carbamazepine

possible

association


Input: Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors.

Psoriasis

imiquimod

triggered


Input: A 52-year-old Black woman on phenytoin therapy for post-traumatic epilepsy developed transient hemiparesis contralateral to the injury.

transient hemiparesis contralateral to the injury

phenytoin

A 52-year-old Black woman

transient

developed


Input: Use of the Naranjo probability scale determined the association between cephalosporin use and leukopenia to be probable.

cephalosporin

leukopenia

probable

use


Input: Sister chromatid exchanges (SCEs), a sensitive measure of chromosome damage, were counted in peripheral-blood lymphocytes from 10 patients with Behcet's syndrome receiving chlorambucil.

10 patients with Behcet's syndrome

chlorambucil

chromosome damage

receiving


Input: Sarcoma complicating therapy with cyclophosphamide.

Sarcoma

cyclophosphamide

complicating


Input: Clozapine induced polyserositis.

Clozapine

polyserositis

induced


Input: Fatal interstitial lung disease after erlotinib administration in a patient with radiation fibrosis.

interstitial lung disease

erlotinib

a patient with radiation fibrosis

Fatal

after


Input: The pharmaceutical company producing Halfan has reported 8 cardiac arrests, leading to 6 deaths, when a higher dose than recommended was used, there was recent or concomitant treatment with mefloquine, there was pre-existing prolongation of the QT interval or the patient had a thiamine deficiency.

Halfan

when a higher dose than recommended was used

8 cardiac arrests

6 deaths

reported


Input: CONCLUSIONS: Fixed drug rash induced by methylphenidate is a possible but rare phenomenon.

Fixed drug rash

methylphenidate

induced


Input: Special care should be taken when pulmonary symptoms appear in association with ticlopidine treatment.

pulmonary symptoms

ticlopidine treatment

appear


Input: CONCLUSION: Although a definite association has not been proven, clinicians should be aware of the possibility of agranulocytosis while using quetiapine.

quetiapine

agranulocytosis

possibility

using


Input: Acute renal failure is a rare complication following the administration of intravenous immunoglobulin (IVIG).

Acute renal failure

intravenous immunoglobulin (IVIG)

complication


Input: We report four patients, three of whom first developed psoriasis and one who had an aggravation of the condition during treatment with interferon-alpha.

one

had an aggravation of the condition

interferon-alpha

with

interferon-alpha

three

psoriasis

developed


Input: Reactivation of cytomegalovirus probably followed the treatment of Wegener's granulomatosis with corticosteroids and azathioprine.

Reactivation of cytomegalovirus

corticosteroids and azathioprine

probably

followed


Input: We present a case of respiratory failure occurring in a woman at 16 weeks' gestation who was being treated with nitrofurantoin for a urinary tract infection.

respiratory failure

a woman at 16 weeks' gestation

being treated with nitrofurantoin for a urinary tract infection

occurring


Input: We describe a case of EGE manifested as an allergy to gemfibrozil.

a case of EGE

gemfibrozil

allergy

manifested


Input: RESULTS: At our institution, no children appeared with acute INH neurotoxicity in the period 1985 through 1990, whereas seven patients were treated from 1991 through 1993.

INH

neurotoxicity

children

appeared with


Input: Two patients on long-term lithium therapy developed the nephrotic syndrome.

Two patients

long-term lithium therapy

nephrotic syndrome

developed


Input: Acute psychosis associated with levetiracetam.

Acute psychosis

levetiracetam

associated


Input: Hypoglycemia induced by long-acting somatostatin analogues in a patient with nonfunctional neuroendocrine tumor.

a patient with nonfunctional neuroendocrine tumor

Hypoglycemia

long-acting somatostatin analogues

induced


Input: CASE REPORT: We report a patient who developed a DAT-positive hemolytic episode after a red cell (RBC) transfusion was delivered during the infusion of her 17th cycle of oxaliplatin.

a patient

developed a DAT-positive hemolytic episode

a red cell (RBC) transfusion was delivered during the infusion of her 17th cycle of oxaliplatin

after


Input: Regression of thyrotoxic ophthalmopathy following lithium withdrawal.

lithium withdrawal

Regression


Input: Mechanism of topiramate-induced acute-onset myopia and angle closure glaucoma.

topiramate

acute-onset myopia and angle closure glaucoma

induced


Input: The clinical symptoms of gastric mucosa foveolar hyperplasia due to long-term PGE1 therapy simulate hypertrophic pyloric stenosis.

gastric mucosa foveolar hyperplasia

simulate hypertrophic pyloric stenosis

long-term PGE1 therapy

due


Input: Aggressive management of doxorubicin-induced cardiomyopathy associated with 'low' doses of doxorubicin.

doxorubicin

'low' doses

cardiomyopathy

induced


Input: Generalized argyria after habitual use of AgNO3.

habitual use of AgNO3

Generalized argyria

after


Input: The authors report the first case of bucillamine-induced giant mammary hyperplasia.

bucillamine

giant mammary hyperplasia

first

induced


Input: Hydroxyurea (HU) and sodium phenylbutyrate (SPB) have been shown to increase fetal hemoglobin (Hb F) levels in patients with thalassemia intermedia.

Hydroxyurea (HU) and sodium phenylbutyrate (SPB)

hemoglobin (Hb F) levels

patients with thalassemia intermedia

fetal

increase


Input: We report a case of biopsy proven myositis whose symptoms began within 10 days of receiving leuprolide acetate therapy for prostate cancer.

myositis

within 10 days of receiving leuprolide acetate therapy

a case

symptoms began


Input: Venlafaxine-induced urinary incontinence resolved after switching to sertraline.

Venlafaxine

urinary incontinence

induced

sertraline

resolved


Input: We report two cases of severe serotonin syndrome induced by the administration of cyclobenzaprine in postoperative patients already receiving another proserotoninergic drug (phenelzine in one case and duloxetine in the other).

serotonin syndrome

cyclobenzaprine

duloxetine

postoperative patients

severe

induced

serotonin syndrome

postoperative patients

cyclobenzaprine

phenelzine

induced


Input: OBJECTIVE: To report 2 cases of serotonin syndrome with serious extrapyramidal movement disorders occurring when metoclopramide was coadministered with sertraline or venlafaxine.

metoclopramide was coadministered with sertraline or venlafaxine

serotonin syndrome with serious extrapyramidal movement disorders

2 cases

occurring


Input: We report a 31-year-old women with recurrent Hodgkin's lymphoma and unrecognized HMSN-1 who developed severe motor neuropathy 3 weeks after the first cycle of treatment including 2 mg of vincristine.

a 31-year-old women with recurrent Hodgkin's lymphoma and unrecognized HMSN-1

severe motor neuropathy

3 weeks after the first cycle of treatment including 2 mg of vincristine

severe

developed


Input: When the patient was treated again with fludarabine nine months later, the DAT became positive with anti-IgG and anti-C3d antiglobulins after the second course of treatment.

the patient

fludarabine

second course of treatment

the DAT became positive with anti-IgG and anti-C3d antiglobulins

treated


Input: This case report describes a patient who was previously prescribed alendronate (Fosamax) and presented with postoperative hypophosphatemia and hypocalcemic tetany after bowel preparation with Fleet Phospho-Soda.

patient

postoperative hypophosphatemia and hypocalcemic tetany

alendronate (Fosamax)

after bowel preparation with Fleet Phospho-Soda

presented


Input: Acute dystonic reaction with low-dose pimozide.

low-dose pimozide

Acute dystonic reaction

with


Input: There are, however, case studies describing patients experiencing recurrences of tics following treatment with atomoxetine.

recurrences of tics

treatment with atomoxetine

following


Input: Nicotinic acid-induced fulminant hepatic failure.

Nicotinic acid

fulminant hepatic failure

induced


Input: Ketanserin in the treatment of protamine-induced pulmonary hypertension.

protamine

pulmonary hypertension.

induced


Input: We have safely used recombinant factor VIIa to treat bleeding in the immediate and long-term period following PCC-related MI.

recombinant factor VIIa

PCC-related MI

treat

PCC

MI

related


Input: Lithium and venlafaxine interaction: a case of serotonin syndrome.

serotonin syndrome

Lithium and venlafaxine interaction

case


Input: The seizures were suspected to be caused by a reduced concentration of VPA in the blood.

reduced concentration of VPA in the blood

seizures

suspected

caused


Input: D-penicillamine induced crescentic glomerulonephritis: report and review of the literature.

D-penicillamine

crescentic glomerulonephritis

induced


Input: We offered several tentative explanations for this event, including an adverse interaction between paroxetine and other agent(s) used in the course of the anaesthesia.

adverse interaction

paroxetine and other agent(s)

between


Input: Neuroleptic malignant syndrome is an uncommon and potentially fatal idiosynchratic reaction of antipsychotic drugs, in which the clinical scenario encompass muscular rigidity, hyperthermia, autonomic dysfunction, altered consciousness, high creatinine phosphokinase levels, and leukocytosis.

Neuroleptic malignant syndrome

muscular rigidity, hyperthermia, autonomic dysfunction, altered consciousness, high creatinine phosphokinase levels, and leukocytosis

antipsychotic drugs

potentially

fatal

reaction


Input: Indinavir-associated nephrolithiasis and chronic interstitial nephritis were the only possible causes identified in this patient.

Indinavir

nephrolithiasis and chronic interstitial nephritis

associated


Input: Gemcitabine is a chemotherapy agent that may cause unpredictable side effects.

Gemcitabine

unpredictable side effects

may

cause


Input: Albendazole-induced pseudomembranous colitis.

Albendazole

pseudomembranous colitis

induced


Input: Tuberculous uveitis after treatment with etanercept.

Tuberculous uveitis

etanercept

after


Input: Salicylate-induced hepatotoxicity is reviewed.

Salicylate

hepatotoxicity

induced


Input: To describe a case of flecainide-induced delirium associated with a pharmacokinetic drug interaction with paroxetine.

flecainide

interaction with paroxetine

delirium

a case

induced


Input: We report on a patient who developed hypersensitivity pneumonitis during treatment with the beta-blocker, celiprolol.

a patient

hypersensitivity pneumonitis

celiprolol

developed


Input: dexmedetomidine is used to provide sedation for pediatric patients undergoing nonpainful radiological imaging studies.

provide sedation

dexmedetomidine

pediatric patients undergoing nonpainful radiological imaging studies

used to


Input: A 71-year-old woman developed serotonin syndrome while receiving treatment with moderate doses of lithium and venlafaxine for refractory depression.

A 71-year-old woman

serotonin syndrome

moderate doses of lithium and venlafaxine

developed


Input: Four years after the beginning of IFN therapy, he acutely developed moderate hyperglycemia and severe ketonuria with positive islet cell antibody, and then 28 units/day of insulin injection was started.

Four years after the beginning of IFN therapy

he

acutely developed moderate hyperglycemia and severe ketonuria with positive islet cell antibody

developed


Input: Tardive dyskinesia in 2 patients treated with ziprasidone.

Tardive dyskinesia

ziprasidone

2 patients

in


Input: The mean time from starting MMF to the development of neutropenia was 4 months.

MMF

neutropenia

development


Input: Fulminant hepatic failure associated with bicalutamide.

Fulminant hepatic failure

bicalutamide

associated


Input: A complex pattern of melanonychia and onycholysis after treatment with pemetrexed for lung cancer.

melanonychia and onycholysis

pemetrexed for lung cancer

treatment


Input: Hypernatraemia induced by sodium polystyrene sulphonate (Kayexalate) in two extremely low birth weight newborns.

Hypernatraemia

sodium polystyrene sulphonate (Kayexalate)

two extremely low birth weight newborns

induced by


Input: Hypoxia is a predisposing factor for premature ductal closure and often occurs after maternal indomethacin therapy.

maternal indomethacin therapy

premature ductal closure

after


Input: Severe histological osteomalacia developed in a woman with Crohn's disease 2 years after ileal resection and the start of cholestyramine therapy.

a woman with Crohn's disease

histological osteomalacia

2 years after ileal resection and the start of cholestyramine

Severe

developed


Input: Serotonin syndrome (SS) and neuroleptic malignant syndrome (NMS) are medical emergencies associated with psychotropic administration.

Serotonin syndrome (SS) and neuroleptic malignant syndrome (NMS)

psychotropic administration

associated


Input: Drug eruption caused by azathioprine: value of using the drug-induced lymphocytes stimulation test for diagnosis.

azathioprine

Drug eruption

caused


Input: Continuous EEG monitoring is helpful in managing seizures that occur as a complication of CBZ OD, after the course of recovery or worsening, and in providing assistance with prognosis.

seizures

a complication of CBZ OD

occur


Input: The fluorine contained in niflumic acid induced a marked densification of trabecular bone in all 3 cases.

fluorine

niflumic acid

marked densification of trabecular bone

all 3 cases

induced


Input: A 17-year-old boy with refractory psoriatic arthritis and alpha-1 antitrypsin deficiency who developed a syringotropic hypersensitivity reaction after 9 months of therapy with infliximab and leflunomide is described.

A 17-year-old boy with refractory psoriatic arthritis and alpha-1 antitrypsin deficiency

syringotropic hypersensitivity reaction

9 months of therapy with infliximab and leflunomide

developed


Input: Managing cardiovascular collapse in severe flecainide overdose without recourse to extracorporeal therapy.

cardiovascular collapse

severe flecainide overdose

in


Input: A 53-year-old Caucasian male victim of suicide was suspected of overdose with sertraline and alprazolam after death-scene investigation.

53-year-old Caucasian male victim of suicide

overdose

sertraline and alprazolam

with


Input: Infliximab therapy may cause a lupus-like syndrome that is reversible upon discontinuing this agent.

Infliximab therapy

lupus-like syndrome

may

cause


Input: A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after withholding medicines.

A 7-year-old with congenital toxoplasmosis

fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis

pyrimethamine and sulfadiazine for reactivated chorioretinitis

severe

developed


Input: Pain management discussion forum: serious interaction among frequently used drugs for chronic pain.

serious interaction

frequently used drugs

serious

among


Input: This kind of reaction is seldom mentioned as occurring during co-administration with tizanidine.

This kind of reaction

co-administration with tizanidine

occurring


Input: A retrospective epidemiological study of deaths from hepatic angiosarcoma (HAS) in the U.S. showed that during 1964--74 there were 168 such cases, of which 37 (22%) were associated with previously known causes (vinyl chloride, 'Thorotrast', and inorganic arsenic) and 4 (3.1%) of the remaining 131 cases with the use of androgenic-anabolic steroids.

37 (22%)

hepatic angiosarcoma

vinyl chloride, 'Thorotrast', and inorganic arsenic

associated

hepatic angiosarcoma

4 (3.1%)

androgenic-anabolic steroids

with


Input: Progressive hypokalemia developed during phosphate treatment.

Progressive hypokalemia

phosphate

developed


Input: A 69-year-old man developed pure red cell aplasia after taking fenoprofen for ten months.

A 69-year-old man

pure red cell aplasia

taking fenoprofen for ten months

developed


Input: Introduction of etanercept was also clinically effective but followed by development of severe heart failure.

etanercept

severe heart failure.

severe

development


Input: Minimal change nephrotic syndrome developing during postoperative interferon-beta therapy for malignant melanoma.

Minimal change nephrotic syndrome

postoperative interferon-beta therapy for malignant melanoma

Minimal

developing


Input: She was admitted following a fall and, after being given metoclopramide, developed movement disorder and a period of unresponsiveness.

metoclopramide

She was admitted following a fall

movement disorder and a period of unresponsiveness

developed


Input: We observed transient panhypogammaglobulinaemia in a patient with neuropsychiatric SLE after treatment with prednisolone and cyclophosphamide.

transient panhypogammaglobulinaemia

a patient with neuropsychiatric SLE

prednisolone and cyclophosphamide

transient

treatment


Input: Isoniazid inhibits the conversion of tryptophan to niacin and may induce pellagra, particularly in poorly nourished patients.

poorly nourished patients

pellagra

Isoniazid

induce


Input: The authors suggest that in patients with corneal ulcers refractory to conventional treatment who are receiving colchicine, cessation of colchicine therapy should be considered.

colchicine

patients with corneal ulcers

receiving


Input: After the patient discontinued rifampicin, the skin lesions cleared completely within 5 weeks without any systemic medication.

patient discontinued rifampicin

skin lesions cleared completely within 5 weeks

After


Input: Ziprasidone is an atypical antipsychotic drug that is believed to have a low propensity for inducing extrapyramidal symptoms, including tardive dyskinesia (TD).

extrapyramidal symptoms, including tardive dyskinesia (TD)

Ziprasidone

low propensity

inducing


Input: Acute ischaemia of the leg following accidental intra-arterial injection of dissolved flunitrazepam tablets.

Acute ischaemia of the leg

intra-arterial injection of dissolved flunitrazepam tablets

following


Input: These findings suggest that prophylactic antibiotic use is unlikely to have a major impact on the recovery time from rocuronium-induced NMB with sugammadex reversal.

prophylactic antibiotic

unlikely to have a major impact on the recovery time

unlikely

use

rocuronium

NMB with sugammadex reversa

induced


Input: Emphasis is given to the differentiation of diphenylhydantoin induced gingival hyperplasia from the angiomatous enlargement of the gingiva before any treatment is planned.

diphenylhydantoin

gingival hyperplasia

the angiomatous enlargement of the gingiva

induced


Input: Electro-oculography, electroretinography, visual evoked potentials, and multifocal electroretinography in patients with vigabatrin-attributed visual field constriction.

visual field constriction

vigabatrin

patients

attributed


Input: CASE SUMMARIES: Two patients with stable hypothyroidism experienced symptoms of hypothyroidism with increased serum thyroid-stimulating hormone (TSH) concentrations after switching from 1 levothyroxine product to another.

hypothyroidism with increased serum thyroid-stimulating hormone

switching from 1 levothyroxine product to another

Two patients with stable hypothyroidism

after


Input: An objective causality assessment indicated a probable relationship between clotting abnormality and warfarin administration, although the degree of elevation of the INR was unusual in the light of the daily warfarin dose and duration of its exposure.

clotting abnormality

warfarin

probable

relationship


Input: The pathophysiological mechanisms remain unknown, although the drug could act through massive cytokines liberation after destruction of CD20 positive cells by rituximab.

massive cytokines liberation

destruction of CD20 positive cells

rituximab

act


Input: The more common grade 3 or 4 adverse effects of sunitinib include hypertension, fatigue, hand-foot syndrome, elevated lipase and lymphopenia.

sunitinib

hypertension, fatigue, hand-foot syndrome, elevated lipase and lymphopenia

adverse effects


Input: We report a 45-year-old psoriasis patient who developed eruptive mollusca contagiosa during an antipsoriatic treatment with efalizumab.

45-year-old psoriasis patient

eruptive mollusca contagiosa

antipsoriatic treatment with efalizumab

developed


Input: Skin necrosis is a rare complication of subcutaneous heparin therapy that usually occurs at injection sites.

Skin necrosis

subcutaneous heparin therapy

complication


Input: Epsilon-aminocaproic acid and renal complications: case report and review of the literature.

renal complications

Epsilon-aminocaproic acid

complications


Input: Ibuprofen rarely causes lower gastrointestinal adverse reactions but has been implicated in systemic and local side effects in patients with lupus.

Ibuprofen

systemic and local side effects in patients with lupus

implicated in


Input: CASE SUMMARIES: While conducting a protocol evaluating the efficacy of intraperitoneal cisplatin and hyperthermia in the treatment of recurrent ovarian cancer, 3 patients were noted to exhibit anaphylactoid reactions.

3 patients

anaphylactoid reactions

intraperitoneal cisplatin and hyperthermia

exhibit


Input: Perinatal vasoconstrictive renal insufficiency associated with maternal nimesulide use.

Perinatal vasoconstrictive renal insufficiency

maternal nimesulide use

associated


Input: Protease inhibitors (ritonavir and saquinavir) were added to the treatment and the patient developed progressive ataxia related to carbamazepine toxicity.

Protease inhibitors (ritonavir and saquinavir) were added to the treatment

carbamazepine

progressive ataxia related to carbamazepine toxicity

the patient

developed


Input: The medical examiner's report indicated death caused by fluoxetine toxicity.

death

fluoxetine toxicity

caused


Input: Hypertonic sodium bicarbonate is recognized as effective therapy for hypotension and arrhythmias.

Hypertonic sodium bicarbonate

effective


Input: Because toxicity may occur when flecainide is prescribed with paroxetine and other potent CYP2D6 inhibitors, flecainide plasma concentrations should be monitored closely with commencement of CYP2D6 inhibitors.

toxicity

flecainide is prescribed with paroxetine and other potent CYP2D6 inhibitors

may

occur


Input: Gentamicin-associated acute renal failure.

Gentamicin

acute renal failure

associated


Input: Sulfasalazine-induced lung disorder is an extremely rare entity which must be considered in all ulcerative colitis patients while on sulfasalazine therapy, despite the absence of pulmonary symptomatology.

Sulfasalazine

lung disorder

induced


Input: Suspected ciprofloxacin-induced interstitial nephritis.

ciprofloxacin

interstitial nephritis

Suspected

induced


Input: Tegaserod-associated ischemic colitis.

Tegaserod

ischemic colitis

associated


Input: Clinicians should be aware of the signs and symptoms of neurotoxicity during treatment, as well as predisposing factors that put patients receiving methotrexate at risk for neurotoxic effects.

methotrexate

neurotoxic effects

patients

risk


Input: We report the first case of chlorambucil-induced DRESS syndrome in a 70-year-old man recently diagnosed with chronic lymphocytic leukaemia.

chlorambucil

DRESS syndrome

a 70-year-old man

induced


Input: Are nasal decongestants safer than rhinitis? A case of oxymetazoline-induced syncope.

oxymetazoline

syncope

induced


Input: Marked elevation of serum creatine kinase associated with olanzapine therapy.

olanzapine therapy

Marked elevation of serum creatine kinase

associated


Input: After cessation of amantadine, the edema resolved, and the endothelial cell densities were <or=600/mm.

the edema resolved, and the endothelial cell densities were <or=600/mm

cessation of amantadine

After