Input: Morphea after bromocriptine therapy.

Morphea

bromocriptine therapy

after


Input: PURPOSE: To describe the clinical and electrophysiological findings in a young boy with decreased vision possibly due to retinal damage by rifabutin.

a young boy

decreased vision

retinal damage

rifabutin

due


Input: We reported a case of disulfiram-induced hepatitis with unique clinical features and compared our case with others in the literature.

a case

disulfiram

hepatitis

induced


Input: We report a patient receiving chronic lithium therapy who presented with a transient CDI occurring in the setting of underlying chronic NDI.

patient

chronic lithium therapy

transient CDI

presented


Input: Here we report a patient with newly diagnosed acute promyelocytic leukemia who developed acute focal myositis, synovitis, and possible vasculitis, after receiving all-trans retinoic acid therapy.

a patient with newly diagnosed acute promyelocytic leukemia

acute focal myositis, synovitis, and possible vasculitis

all-trans retinoic acid

developed


Input: We report a case of methotrexate toxicity potentially induced by a drug interaction between methotrexate and omeprazole in a 25-year-old man with osteosarcoma.

a 25-year-old man with osteosarcoma

methotrexate toxicity

methotrexate and omeprazole

potentially

induced


Input: Increasing the olanzapine dosage severely aggravated the symptoms of RLS.

Increasing the olanzapine dosage

symptoms of RLS

aggravated


Input: We report a case of 48-year-old woman with seizure disorder on divalproex sodium (Depakote) who presented with dyspnea.

a case of 48-year-old woman with seizure disorder

dyspnea

divalproex sodium (Depakote)

presented


Input: To report a probable interaction between warfarin and marijuana smoking, resulting in increased international normalized ratio (INR) values and bleeding complications.

interaction between warfarin and marijuana smoking

increased international normalized ratio (INR) values and bleeding complications

probable

resulting


Input: Transient cardiac arrhythmias related to lopinavir/ritonavir in two patients with HIV infection.

Transient cardiac arrhythmias

lopinavir/ritonavir

two patients with HIV infection

related


Input: Interestingly, the use of carboplatin (CBDCA) and VDS in the subsequent treatment course was well tolerated indicating that the SIADH was most likely to have been induced by administration of CDDP.

SIADH

CDDP

most likely to

induced


Input: Although heparin-dependent antibodies (HDAs) typically manifest with thrombocytopenia as in heparin-induced thrombocytopenia (HIT), they may also manifest with preserved platelet counts.

thrombocytopenia

heparin-dependent antibodies (HDAs)

typically

manifest


Input: A 69-year-old white female whose anticoagulation treatment had been stable for 18 months with warfarin 2.5 mg daily (17.5 mg/wk) presented to an anticoagulation clinic with a critically elevated INR of greater than 12.3 after a dose increase in extended-release niacin (Niaspan) from 500 mg to 1000 mg daily the previous week.

69-year-old white female

elevated INR of greater than 12.3

anticoagulation treatment had been stable for 18 months with warfarin 2.5 mg daily (17.5 mg/wk)

dose increase in extended-release niacin (Niaspan) from 500 mg to 1000 mg daily the previous week

critically

after


Input: The most serious dental side effect of bisphosphonate treatment (particularly when it is administered intravenously) is, paradoxically, osteonecrosis of the mandible or the maxilla represented by exposed nonhealing bone.

bisphosphonate treatment (particularly when it is administered intravenously)

osteonecrosis of the mandible or the maxilla represented by exposed nonhealing bone

side effect


Input: Pericardial hemorrhage due to acetylsalicylic acid in a patient with essential thrombocythemia.

Pericardial hemorrhage

acetylsalicylic acid

due


Input: These cases and a review of the literature suggested that hepatotoxicity, though rare, should be added to the list of adverse reactions to D-penicillamine.

These cases

D-penicillamine

hepatotoxicity

adverse


Input: After four months, while receiving RH, he developed painful bilateral gynaecomastia.

receiving RH

painful bilateral gynaecomastia

developed


Input: The plasma concentrations of both drugs were significantly increased during the coadministration, and the cetirizine concentration decreased on cessation of pilsicainide despite the fact that treatment with cetirizine was continued, which suggested that the fainting was induced by the pharmacokinetic drug interaction.

fainting

pilsicainide

cetirizine

induced


Input: OBJECTIVE: To report a case of multiple episodes of seizure activity in an AIDS patent following amphotericin B infusion.

multiple episodes of seizure activity

an AIDS patent

amphotericin B infusion

following


Input: The vomiting occurred on switching to different pancreatic enzymes preparations, ie, Creon 10, Viokase, and Pancrease MT 16.

different pancreatic enzymes preparations, ie, Creon 10, Viokase, and Pancrease MT 16

vomiting

switching


Input: Although tardive dyskinesia is a known adverse reaction of sustained treatment with traditional neuroleptic agents, it was only rarely reported in association with sulpiride, a selective D2-receptor antagonist.

tardive dyskinesia

sulpiride

association


Input: This report highlights a case of drug-induced dysphagia in a patient receiving haloperidol for obsessive nocturnal thoughts and auditory disturbances.

haloperido

a patient

dysphagia

induced


Input: In addition to disease refractoriness, rare instances of disease progression from chronic phase to blast crisis during imatinib therapy have recently been anecdotally reported.

imatinib therapy

disease progression from chronic phase to blast crisis

during


Input: We report a typical case of transient serotonin syndrome secondary to tramadol-Citalopram combination.

transient serotonin syndrome

tramadol-Citalopram combination

a typical case

secondary


Input: Although use of the Naranjo adverse reaction probability scale indicated a probable relationship (score of 6) between the patient's development of methotrexate toxicity and omeprazole use, we believe this was a drug-drug interaction case consistent with previous reports in the literature.

the patient

methotrexate toxicity

methotrexate

and omeprazole use

probable

relationship


Input: Systemic cyclosporin (10 mg/kg/day) resulted in resolution of the corneal ulceration within two weeks of beginning treatment, and the patient has remained in remission after 15 months of therapy.

Systemic cyclosporin (10 mg/kg/day)

resolution of the corneal ulceration

patient

resulted


Input: We report a 59-year-old patient with chronic myeloid leukemia, who developed severe interstitial lung fibrosis after short term and sequential treatment with melphalan and busulfan.

interstitial lung fibrosis

short term and sequential treatment with melphalan and busulfan

a 59-year-old patient with chronic myeloid leukemia

severe

developed


Input: Does the use of insulin in a patient with liver dysfunction increase water retention in the body, i.e. cause insulin oedema?

insulin

a patient with liver dysfunction

increase water retention in the body, i.e. cause insulin oedema?

Does

use


Input: Sustained hypothyroidism induced by recombinant alpha interferon in patients with chronic hepatitis C.

Sustained hypothyroidism

recombinant alpha interferon

patients with chronic hepatitis C

induced


Input: Withdrawal of Depakote resulted in resolution of the effusion.

Withdrawal of Depakote

resolution of the effusion

resulted


Input: Adenosine-induced ventricular fibrillation.

ventricular fibrillation

Adenosine

induced


Input: Evaluation of initial and steady-state gatifloxacin pharmacokinetics and dose in pulmonary tuberculosis patients by using monte carlo simulations.

gatifloxacin

pulmonary tuberculosis patients

in


Input: We report two patients with acne vulgaris with a fourth type of minocycline-induced cutaneous pigmentation.

minocycline

two patients with acne vulgaris

fourth type of

cutaneous pigmentation

induced


Input: Budesonide is a synthetic glucocorticosteroid that is commonly used in topical treatment of asthma and rhinitis.

Budesonide

used in


Input: Cyclosporin therapy in Mooren's ulcer.

Cyclosporin

therapy


Input: She developed neurotoxicity with an adjustment dosage of valacyclovir for a cutaneous zoster infection.

neurotoxicity

adjustment dosage of valacyclovir

She

developed


Input: Nine eyes from 6 patients, 74 years to 90 years of age, referred by ophthalmologists for repair of cicatricial entropion after at least 2 years of twice-a-day application of dipivefrin.

at least 2 years of twice-a-day application of dipivefrin

cicatricial entropion

Nine eyes from 6 patients, 74 years to 90 years of age

after


Input: We report 5 patients (3 patients with chronic hepatitis C treated with pegylated interferon alfa-2b in association with oral ribavirin and two patients with chronic myelocytic leukemia) who developed local cutaneous reactions at sites of injection after the administration of weekly subcutaneous injections of pegylated interferon alfa-2b at different doses.

two patients with chronic myelocytic leukemia

local cutaneous reactions at sites of injection

administration of weekly subcutaneous injections of pegylated interferon alfa-2b at different doses

developed

local cutaneous reactions at sites of injection

3 patients with chronic hepatitis C

pegylated interferon alfa-2b in association with oral ribavirin

developed


Input: Artemether-lumefantrine (AL) is first-line treatment for uncomplicated malaria in many African countries.

Artemether-lumefantrine (AL)

first-line treatment


Input: Functional regulation of certain neuroreceptors during risperidone treatment may lead to altered behavioural responses upon switching to methylphenidate.

risperidone

switching to methylphenidate

altered behavioural responses

may

lead


Input: Transient leucopenia and thrombocytopenia associated with sodium nitroprusside infusion.

sodium nitroprusside infusion

Transient leucopenia and thrombocytopenia

Transient

associated


Input: This unusual pattern of low-grade endometrial carcinoma adds to the spectrum of uterine neoplasia associated with tamoxifen therapy.

tamoxifen

unusual pattern of low-grade endometrial carcinoma adds to the spectrum of uterine neoplasia

associated


Input: Inappropriate antidiuretic hormone secretion after high dose vinblastine.

Inappropriate antidiuretic hormone secretion

high dose vinblastine

after


Input: Osteomyelitis occurring during infliximab treatment of severe psoriasis.

Osteomyelitis

infliximab

severe

treatment


Input: We describe a patient with transitional cell carcinoma of the renal pelvis who developed respiratory dysfunction and an abnormal chest x-ray with diffuse interstitial opacities while on chemotherapy with piritrexim, a methotrexate analog.

chemotherapy with piritrexim, a methotrexate analog

a patient with transitional cell carcinoma of the renal pelvis

respiratory dysfunction and an abnormal chest x-ray with diffuse interstitial opacities

developed


Input: Amiodarone induced torsades de pointe.

Amiodarone

torsades de pointe

induced


Input: A patient with Wegener's granulomatosis rapidly developed a circumferential subglottic stenosis while on a cyclophosphamide regimen that had caused resolution of systemic symptoms and pulmonary infiltrates.

A patient with Wegener's granulomatosis

circumferential subglottic stenosis

resolution of systemic symptoms and pulmonary infiltrates

cyclophosphamide regimen

developed


Input: A case is presented which illustrates a probably fatal interaction between minoxidil and a coagulation disorder.

minoxidil

A case

fatal interaction

probably

between


Input: Methadone-induced myoclonus in advanced cancer.

Methadone

myoclonus

induced


Input: Life-threatening anaphylactoid reaction to amifostine used with concurrent chemoradiotherapy for nasopharyngeal cancer in a patient with dermatomyositis: a case report with literature review.

a patient with dermatomyositis

amifostine used with concurrent chemoradiotherapy

Life-threatening anaphylactoid reaction

Life-threatening

to


Input: We conclude that while thrombocytopenia and schistocytosis can be seen in quinine-associated TTP/HUS, the pathophysiology seems to be distinct from that seen in most cases of idiopathic TTP (i.e., severely decreased ADAMTS13 with an inhibitor).

quinine

thrombocytopenia and schistocytosis

TTP/HUS

associated


Input: CONCLUSIONS: Spontaneous hemothorax is a rare phenomenon in conjunction with LMWH but should be considered in cases of acute respiratory distress following commencement of LMWH.

Spontaneous hemothorax

acute respiratory distress

LMWH

considered


Input: CONCLUSION: These cases suggest that moxifloxacin may interfere with the healing of corneal ulcers.

moxifloxacin

interfere with the healing of corneal ulcers

These cases

may

interfere


Input: Reinstitution of penicillamine treatment caused a recurrence thus proving a causal relationship between penicillamine and the described nail-changes.

penicillamine

nail-changes

proving

causal relationship


Input: A 34-year-old lady developed a constellation of dermatitis, fever, lymphadenopathy and hepatitis, beginning on the 17th day of a course of oral sulphasalazine for sero-negative rheumatoid arthritis.

A 34-year-old lady

a constellation of dermatitis, fever, lymphadenopathy and hepatitis

a course of oral sulphasalazine

developed


Input: He had been commenced on a course of fusidic acid at discharge in addition to his ongoing statin prescription and presented 4 weeks later with symptoms consistent with rhabdomyolysis.

a course of fusidic acid at discharge in addition to his ongoing statin prescription

symptoms consistent with rhabdomyolysis

presented


Input:
1.
Artelinic acid (AL), a water-soluble artemisinin analogue for treatment of multidrug resistant malaria, is metabolized to the active metabolite dihydroqinghaosu (DQHS) solely by  CYP3A4/5.

Artelinic acid (AL), a water-soluble artemisinin analogue

treatment


Input: Inhaled tobramycin solution-associated recurrent eosinophilia and severe persistent bronchospasm in a patient with cystic fibrosis: a case report.

Inhaled tobramycin

recurrent eosinophilia and severe persistent bronchospasm

a patient with cystic fibrosis

severe

associated


Input: The occurrence of BMTN in two children treated with RA in our unit is unlikely to be coincidental.

BMTN

two children

RA

treated


Input: Comeoscleral perforation after pterygium excision and intraoperative mitomycin C.

Comeoscleral perforation

pterygium excision and intraoperative mitomycin C

after


Input: Capecitabine-induced multifocal leukoencephalopathy: a report of five cases.

multifocal leukoencephalopathy

five cases

Capecitabine

induced


Input: Vigabatrin-induced visual field defects are at present the most important safety issue in the use of the drug.

Vigabatrin

visual field defects

induced


Input: Serotonin syndrome in elderly patients treated for psychotic depression with atypical antipsychotics and antidepressants: two case reports.

elderly patients

atypical antipsychotics

antidepressants

Serotonin syndrome

with


Input: We report two new cases of sarcoidosis in two patients with hepatitis C virus infection treated with interferon alfa and ribavirin.

interferon alfa and ribavirin

sarcoidosis

two patients with hepatitis C virus infection

in


Input: A 57-year-old man developed morphea while taking bromocriptine.

bromocriptine

morphea

A 57-year-old man

taking


Input: Potential mechanisms regarding the pathophysiology of lithium-associated CDI are discussed.

lithium

CDI

Potential

associated

associated


Input: Acute coronary syndromes complicating the first infusion of rituximab.

Acute coronary syndromes

the first infusion of rituximab

complicating


Input: Spontaneous hemothorax following anticoagulation with low-molecular-weight heparin.

low-molecular-weight heparin

Spontaneous hemothorax following anticoagulation

with


Input: There were no incremental increases in myelosuppression, peripheral neuropathy, or renal, hepatic, or cardiac toxicity and no deaths related to tirapazamine.

tirapazamine

no incremental increases in myelosuppression, peripheral neuropathy, or renal, hepatic, or cardiac toxicity and no deaths

no

related


Input: A phase III trial, Cisplatin and Tirapazamine in Subjects with Advanced Previously Untreated Non-Small-Cell Lung Tumors (CATAPULT I), was designed to determine the efficacy and safety of tirapazamine plus cisplatin for the treatment of non-small-cell lung cancer (NSCLC).

tirapazamine plus cisplatin

treatment


Input: Combination antimicrobial regimens (e.g., linezolid with rifampin) aimed at improving bacterial eradication and preventing resistance are often used; however, most data supporting this treatment strategy are not from randomized controlled trials.

Combination antimicrobial regimens (e.g., linezolid with rifampin)

improving bacterial eradication and preventing resistance

aimed


Input: Clinicians treating elderly patients with a combination of serotonergic antidepressants and atypical antipsychotics for psychotic depression should be aware of the potential for serotonin syndrome.

serotonin syndrome

elderly patients

a combination of serotonergic antidepressants and atypical antipsychotics for psychotic depression

potential

be aware


Input: Enalaprilat induced acute parotitis.

Enalaprilat

acute parotitis

induced


Input: We believe the most likely cause was hepatic inhibition of the CYP3A4 hepatic isoenzyme by fusidic acid resulting in an acute severe rise in plasma simvastatin level and extensive myocellular damage.

fusidic acid

an acute severe rise in plasma simvastatin level and extensive myocellular damage

most likely cause

resulting


Input: The authors describe pericardial hemorrhage, which is related to the use of low-dose acetylsalicylic acid in a patient with essential thrombocythemia.

pericardial hemorrhage

low-dose acetylsalicylic acid

a patient with essential thrombocythemia

related


Input: This complex pattern of nail and skin changes is accounted by synergy or an additive effect of chemotherapy agents on cellular proliferation of nail compartments.

chemotherapy agents

complex pattern of nail and skin changes

synergy or an additive effect


Input: Akathisia is a relatively rare side effect with the newer atypical antipsychotic agents, particularly clozapine, and is easily misdiagnosed in children.

i

clozapine

Akathisia

with


Input: In this case, discontinuing piroxicam, a nonsteroidal anti-inflammatory drug, and starting a palliative treatment plan helped resolve a patient's ulcers.

discontinuing piroxicam, a nonsteroidal anti-inflammatory drug, and starting a palliative treatment

a patient's

resolve


Input: Eosinophilia has been encountered from 0.2 to 61.7% in clozapine-treated patients, mostly with a transient course and spontaneous remission.

clozapine

Eosinophilia

patients

encountered


Input: We presented a patient with status asthmaticus treated with a combination of theophylline and prednisone who developed a perforated gastric ulcer.

a patient with status asthmaticus

perforated gastric ulcer

theophylline and prednisone

developed


Input: We speculate on a causal relationship between the assumption of the additives and the fatal hepatitis and envisage a synergy between the additives and montelukast, which per se has well been studied as a hepatotoxic drug.

montelukast

the fatal hepatitis

speculate

fatal

relationship


Input: Fatal liver failure following food supplements during chronic treatment with montelukast.

Fatal liver failure

food supplements during chronic treatment with montelukast

Fatal

following


Input: The nodules regressed after withdrawal of methotrexate therapy in one patient and were arrested with the addition of hydroxychloroquine in the other.

withdrawal of methotrexate therapy

one patient

regressed

after

one patient

the other

the addition of hydroxychloroquine

arrested

with


Input: Treatment of carbimazole-induced agranulocytosis and sepsis with granulocyte colony stimulating factor.

granulocyte colony stimulating factor

Treatment


Input: A study following large patient groups on theophylline and a combination of theophylline and steroids might clarify the risk of ulcer formation in patients being treated with these medications for asthma.

large patient groups

ulcer

theophylline and a combination of theophylline and steroids

might

risk


Input: The combination of cyclobenzaprine and fluoxetine resulted in significant QT prolongation in our patient that progressed to torsade de pointes after preoperative droperidol administration.

The combination of cyclobenzaprine and fluoxetine

preoperative droperidol administration

significant QT prolongation

progressed to torsade de pointes

our patient

resulted


Input: INTRODUCTION-The aim of this case report is to present a 15-year follow-up of a patient with phenytoin (PHT) intoxication with unilateral gingival hyperplasia (GH).

phenytoin (PHT) intoxication with unilateral gingival hyperplasia (GH)

phenytoin

a patient

intoxication


Input: This severe illness was likely caused by minocycline, and we speculate that minocycline may have acted as a superantigen, causing lymphocyte over-activation and massive cytokine release.

severe illness

minocycline

likely

caused


Input: RESULTS: Three patients who developed symptoms of inflammatory bowel disease (IBD) during rofecoxib exposure are described along with pathology findings.

Three patients

symptoms of inflammatory bowel disease (IBD)

rofecoxib exposure

developed


Input: Radiation recall refers to inflammatory reactions triggered by cytotoxic agents and develops in previously irradiated areas.

cytotoxic agents

Radiation recall

inflammatory reactions

triggered


Input: Herein, we describe 2 patients who developed unusual CD8+ cutaneous lymphoproliferative disorders after treatment with efalizumab and infliximab.

2 patients

CD8+ cutaneous lymphoproliferative

efalizumab and infliximab

developed


Input: Intrathecal methotrexate-induced acute cerebellar syndrome.

methotrexate

acute cerebellar syndrome

induced


Input: Barbiturate-induced submassive hepatic necrosis.

Barbiturate

submassive hepatic necrosis

induced


Input: The possible effects of tamoxifen upon the uterus are discussed in this article, in view of reports of tamoxifen associated with endometrial carcinoma and endometriosis.

endometrial carcinoma and endometriosis

tamoxifen

possible

associated


Input: Three patients who had experienced neuroleptic-induced akathisia in the past reported that the symptoms of fluoxetine-induced akathisia were identical, although somewhat milder.

Three patients

fluoxetine

akathisia

milder

induced

Three patients

neuroleptic

akathisia

induced


Input: Intranasal desmopressin-induced hyponatremia.

Intranasal desmopressin

hyponatremia

induced


Input: Sunburn may sometimes be a major injury in psoralen users because high doses or inappropriate use of the drug may render the skin extremely sensitive.

Sunburn

skin extremely sensitive

psoralen users because high doses or inappropriate use

users

may

render


Input: Methotrexate-induced leukoencephalopathy is treatable with high-dose folinic acid: a case report and analysis of the literature.

high-dose folinic acid

treatable

Methotrexate

leukoencephalopathy

induced


Input: We reviewed the records of 3 patients with lymphoproliferative disorders who experienced acute coronary syndromes associated with their initial infusion of rituximab.

3 patients with lymphoproliferative disorders

acute coronary syndromes

their initial infusion of rituximab

associated


Input: Previous successful treatment with one ACE inhibitor does not rule out the vasculitis caused by the drug from the same group.

ACE inhibitor

vasculitis

does not rule out

caused


Input: We report a patient with pulmonary adenocarcinoma complicated by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following systemic chemotherapy with cisplatin (CDDP) and vindesine (VDS).

a patient with pulmonary adenocarcinoma

the syndrome of inappropriate secretion of antidiuretic hormone (SIADH)

systemic chemotherapy with cisplatin (CDDP) and vindesine (VDS)

following


Input: Our patient had headache, mild fever, nausea, vomiting, rash, and eosinophilia after 3 weeks of disulfiram therapy.

headache, mild fever, nausea, vomiting, rash, and eosinophilia

after 3 weeks of disulfiram

after


Input: Decreased serum linezolid levels in a critically ill patient receiving concomitant linezolid and rifampin.

Decreased serum linezolid levels

a critically ill patient

concomitant linezolid and rifampin

receiving


Input: OBJECTIVE: To report the first five cases of amphotericin B overdose with secondary cardiac complications in a pediatric population.

amphotericin B overdose

cardiac complications

first five cases of

a pediatric population

secondary


Input: CONCLUSIONS: Amphotericin B seems to be the probable cause of the seizures.

Amphotericin B

seizures

probable

cause


Input: We describe a patient who developed acute cerebellar syndrome after prophylactic intrathecal methotrexate administration and recovered spontaneously.

acute cerebellar syndrome

a patient

prophylactic intrathecal methotrexate administration

developed


Input: Levofloxacin induced polymorphic ventricular tachycardia with normal QT interval.

Levofloxacin

polymorphic ventricular tachycardia with normal QT interval

induced


Input: Most physicians are aware of serotonin syndrome secondary to antidepressants but do not think about other classes of medications such as analgesics.

serotonin syndrome

antidepressants

do not think about

secondary


Input: Renal toxicity signs, induced by amphotericin B, progression of infection after fluconazole, and likely in vivo resistance to this triazole made this case difficult to treat.

Renal toxicity signs

amphotericin B

induced

infection

fluconazole

after


Input: We describe two patients with aspergillus arthritis of the knee joint following fludarabine-based non-myeloablative stem cell transplantation.

two patients

fludarabine-based non-myeloablative stem cell transplantation

aspergillus arthritis of the knee joint

following


Input: A case of fluoxetine induced seizures, in a person with Down syndrome, is described.

fluoxetine

seizures

a person with Down syndrome

induced


Input: We report a case of acute generalized exanthematous pustulosis (AGEP) induced by salazosulfapyridine in a patient with ulcerative colitis.

acute generalized exanthematous pustulosis (AGEP)

salazosulfapyridine

a patient with ulcerative colitis

induced by


Input: Diclofenac-associated hepatitis.

hepatitis

Diclofenac

associated


Input: Angioimmunoblastic lymphadenopathy with dysproteinemia following doxycycline administration.

doxycycline administration

Angioimmunoblastic lymphadenopathy with dysproteinemia

following


Input: Doxycycline-induced hypoglycemia in a nondiabetic young man.

Doxycycline

a nondiabetic young man

hypoglycemia

induced


Input: Case 2 demonstrated after 40 months on chlorambucil the presence of a balanced translocation, t (1;5) (p36;q31) in 90% of the cells.

a balanced translocation, t (1;5) (p36;q31) in 90% of the cells

40 months on chlorambucil

Case 2

presence of


Input: Within 6 months of pranlukast withdrawal, anemia resolved and urinary sediment and renal function normalized.

pranlukast

anemia resolved and urinary sediment and renal function normalized

withdrawal


Input: Sirolimus-associated hepatotoxicity in the kidney graft recipient.

Sirolimus

hepatotoxicity

kidney graft recipient.

associated


Input: Although vasculitis has been reported in the course of hairy cell leukaemia, it has only rarely been reported as the consequence of cladribine treatment.

vasculitis

cladribine

rarely

consequence


Input: Despite aggressive medical management, including intravenous hydration and broad-spectrum antibiotics, the patient continued to become more confused, agitated, and despondent over the subsequent 24 hours.

patient

intravenous hydration and broad-spectrum antibiotics

become more confused, agitated, and despondent over the subsequent 24 hours

continued

continued


Input: Cyclosporine is a potent inhibitor of simvastatin metabolism, and may therefore facilitate simvastatin-induced rhabdomyolysis.

Cyclosporine is a potent inhibitor of simvastatin metabolism

may

facilitate


Input: The effect of food consumption on lumefantrine bioavailability in African children receiving artemether-lumefantrine crushed or dispersible tablets (Coartem) for acute uncomplicated Plasmodium falciparum malaria.

African children

artemether-lumefantrine crushed or dispersible tablets (Coartem)

receiving


Input: To report 2 cases of serotonin toxicity (ST) associated with concomitant use of linezolid and serotonergic drugs and review previously published case reports.

2 cases

concomitant use of linezolid and serotonergic drugs

serotonin toxicity (ST)

associated


Input: This case illustrates that the hemophagocytic syndrome associated with reactivation of EBV can occur as part of drug hypersensitivity reactions in RA patients taking sulfasalazine.

sulfasalazine

the hemophagocytic syndrome associated with reactivation of EBV

occur


Input: Tardive dyskinesia induced by sulpiride.

Tardive dyskinesia

sulpiride

induced


Input: Seizures occurred in two patients with probable Alzheimer's disease who were receiving long-term treatment with metrifonate, an irreversible acetylcholinesterase inhibitor.

two patients with probable Alzheimer's disease

long-term treatment with metrifonate

Seizures

occurred


Input: High-dose antithrombin III was associated with an increased risk of hemorrhage when administered with heparin.

hemorrhage

High-dose antithrombin III

heparin

risk

increased


Input: With the increasing use of Cyclosporine A in transplant patients, the incidence of herpes esophagitis may increase.

Cyclosporine A

transplant patients

herpes esophagitis may increase.

may

incidence


Input: After starting nevirapine treatment, nine out of ten patients experienced symptoms of abstinence syndrome, and methadone dose had to be increased by 20% on average during the course of the study.

nine out of ten patients

nevirapine

abstinence syndrome

experienced


Input: Treatment was begun with amphotericin B-deoxycholate but renal toxicity signs led to its substitution by fluconazole.

amphotericin B-deoxycholate

renal toxicity

signs


Input: Post marketing studies of Interferon-beta (IFN beta) therapy in multiple sclerosis (MS) have demonstrated surprisingly high rates of hepatotoxicity.

Interferon-beta

hepatotoxicity

demonstrated


Input: We describe the first case of disseminated salmonellosis in a patient treated with temozolomide.

disseminated salmonellosis

a patient

temozolomide

in


Input: OBJECTIVE: To describe a case of exacerbated mania potentially related to an interaction between lopinavir/ritonavir and valproic acid (VPA) and propose a mechanism of action for this interaction.

exacerbated mania

interaction between lopinavir/ritonavir and valproic acid

potentially

related


Input: The first reported case, in an adult, of cholestyramine induced hyperchloremic metabolic acidosis is a 70 year old female with a two year history of primary biliary cirrhosis confirmed by histologic and immunologic criteria.

a 70 year old female with a two year history of primary biliary cirrhosis

cholestyramine

hyperchloremic metabolic acidosis

induced


Input: We report a case of fatal C. neoformans fungemia in a neutropenic patient with a history of chronic lymphocytic leukemia treated with alemtuzumab.

alemtuzumab

fatal C. neoformans fungemia

a neutropenic patient with a history of chronic lymphocytic leukemia

treated with


Input: Aggressive hydration, urinary alkalinization, and leucovorin were continued during the period of elevated methotrexate levels, with the patient receiving a course of hemodialysis and a dose of carboxypeptidase G2.

Aggressive hydration, urinary alkalinization, and leucovorin

elevated methotrexate

course of hemodialysis and a dose of carboxypeptidase G2

the patient

continued


Input: Acute myocardial infarction due to coronary spasm associated with L-thyroxine therapy.

L-thyroxine

Acute myocardial infarction due to coronary spasm

associated


Input: Only patients on DT-PACE but not DCEP-T experienced an increased incidence of DVT.

an increased incidence of DVT

DT-PACE but not DCEP-T

patients

experienced


Input: To our knowledge, this is the first published report of a possible drug interaction in a critically ill patient receiving concomitant linezolid and rifampin.

drug interaction

a critically ill patient

concomitant linezolid and rifampin

possible

receiving


Input: Within 24 hours of fluid restriction and cessation of desmopressin, her symptoms and hyponatremia resolved.

24 hours of fluid restriction and cessation of desmopressin

symptoms and hyponatremia

her

resolved


Input: An adverse reaction to IFN was strongly suspected as the cause of CHF.

CHF

IFN

strongly suspected

cause


Input: A 51-year old physically fit woman experienced angio-oedema and hypotensive shock after irbesartan ingestion requiring noradrenaline infusion.

A 51-year old physically fit woman

angio-oedema and hypotensive shock

irbesartan ingestion

experienced


Input: Our report suggested that CBDCA hypersensitivity was correlated with the total dose of previously administered platinum agents and that CBDCA should be excluded in patients who have received multiple platinum-based chemotherapy, even in platinum-sensitive cases, because CBDCA hypersensitivity can occur even with low-dose CBDCA administration.

CBDCA hypersensitivity

total dose of previously administered platinum agents

suggested

correlated


Input: Lansoprazole-induced thrombocytopenia.

Lansoprazole

thrombocytopenia

induced


Input: Cutaneous necrosis as a result of interferon alfa is an infrequent complication with unknown pathogenesis, in which a cutaneous local immune-mediated inflammatory process might be involved.

interferon alfa

Cutaneous necrosis

result


Input: Torsade de pointes resulting from the addition of droperidol to an existing cytochrome P450 drug interaction.

Torsade de pointes

droperidol

cytochrome P450

resulting


Input: Sulfasalazine-induced hypersensitivity syndrome and hemophagocytic syndrome associated with reactivation of Epstein-Barr virus.

Sulfasalazine

hypersensitivity syndrome and hemophagocytic syndrome

induced


Input: OBJECTIVES: The authors described a case of Hashimoto's disease during interferon-alpha (IFN-alpha) treatment for chronic viral C hepatitis in a patient with the specific genetic susceptibility associated with the thyroid disease.

Hashimoto's disease

interferon-alpha (IFN-alpha) treatment

a patient with the specific genetic susceptibility associated with the thyroid disease

during


Input: Nephrogenic diabetes insipidus (NDI) is a well-documented complication of lithium use.

Nephrogenic diabetes insipidus (NDI)

lithium

complication


Input: Serotonin toxicity associated with concomitant use of linezolid.

Serotonin toxicity

concomitant use of linezolid

Serotonin

associated


Input: We report the case of a 30-year-old male after kidney transplantation, treated with steroids, cyclosporin A and SRL, with steroid-resistant acute rejection in anamnesis.

the case of a 30-year-old male

kidney transplantation, treated with steroids, cyclosporin A and SRL

steroid-resistant acute rejection

after


Input: Infants are particularly susceptible to chronic nitrate-induced methemoglobinemia because of their low stomach acid production, large numbers of nitrite-reducing bacteria, and the relatively easy oxidation of fetal hemoglobin.

nitrate

methemoglobinemia

Infants

induced


Input: A 72-year-old woman with renal insufficiency who was taking oral pilsicainide (150 mg/d) complained of feeling faint 3 days after she was prescribed oral cetirizine (20 mg/d).

A 72-year-old woman with renal insufficiency

taking oral pilsicainide (150 mg/d)

3 days after she was prescribed oral cetirizine (20 mg/d)

feeling faint

complained


Input: Chronic hydroxychloroquine use associated with QT prolongation and refractory ventricular arrhythmia.

QT prolongation and refractory ventricular arrhythmia

Chronic hydroxychloroquine

associated


Input: This increase when clozapine was switched to risperidone and vice versa is consistent with our previous report of elevated serum triglyceride levels in clozapine-treated patients.

clozapine was switched to risperidone and vice versa

patients

consistent


Input: Sensorimotor polyneuropathy with 5-aminosalicylic acid: a case report.

Sensorimotor polyneuropathy

5-aminosalicylic acid

a case

with


Input: Hydrocortisone prophylaxis and verapamil therapy were the primary therapies used in patient 1 (the only survivor).

patient 1 (the only survivor)

Hydrocortisone prophylaxis and verapamil therapy

therapies


Input: The clinical aspect closely resembled classical transient global amnesia but the episode after clioquinol lasted longer (24 hours to three days) and a more or less extensive retrograde amnesia persisted permanently.

classical transient global amnesia

a more or less extensive retrograde amnesia

clioquinol

after


Input: We report a case of AILD in an 80-year-old male who presented with a generalized pruritic maculopapular eruption and fever following doxycycline administration.

doxycycline administration

generalized pruritic maculopapular eruption and fever

a case of AILD in an 80-year-old male

presented


Input: OBJECTIVE: To our knowledge, this is the first published case report of an adolescent girl with a mitochondrial disorder and depression who displayed both new-onset psychotic and increased mood symptoms during treatment with risperidone.

risperidone

an adolescent girl with a mitochondrial disorder and depression

new-onset psychotic and increased mood symptoms

To our knowledge

during


Input: Young children undergoing cisplatin chemotherapy are known to be at risk for progressive sensorineural hearing loss.

Young children

undergoing cisplatin chemotherapy

progressive sensorineural hearing loss

risk


Input: Systemic capillary leak syndrome after granulocyte colony-stimulating factor (G-CSF).

Systemic capillary leak syndrome

granulocyte colony-stimulating factor (G-CSF)

after


Input: CASE SUMMARIES: Two patients who received ifosfamide-containing chemotherapy developed NCSE.

Two patients

ifosfamide-containing chemotherapy

NCSE

developed


Input: One of the monohydroxy-metabolites has been incriminated with tacrine-induced hepatotoxicity.

tacrine

hepatotoxicity

induced


Input: BACKGROUND: To assess the nature, incidence, and risk factors of retinopathy associated with pegylated interferon and ribavirin combination therapy in chronic hepatitis C patients.

retinopathy

pegylated interferon and ribavirin combination therapy

chronic hepatitis C patients

associated


Input: Thrombogenic activity of doxorubicin in myeloma patients receiving thalidomide: implications for therapy.

myeloma patients

doxorubicin

thalidomide

Thrombogenic activity

receiving


Input: Agranulocytosis is a rare adverse effect associated with prolonged vancomycin therapy, and is potentially serious, especially in end stage renal disease (ESRD) patients.

Agranulocytosis

prolonged vancomycin therapy

end stage renal disease (ESRD) patients

potentially serious

associated


Input: Thiopurine methyltransferase deficiency occurs at a frequency of one in 300 and is associated with profound myelosuppression after a short course of azathioprine.

a short course of azathioprine

profound myelosuppression

profound

after


Input: Hypotension and sinus arrest with nifedipine in pulmonary hypertension.

Hypotension and sinus arrest

nifedipine

with


Input: We describe children and adolescents with chronic hematologic and oncologic diseases who exhibited drug-seeking behavior or anticholinergic symptoms with the use of diphenhydramine.

children and adolescents with chronic hematologic and oncologic diseases

drug-seeking behavior or anticholinergic symptoms

diphenhydramine

exhibited


Input: Transient central diabetes insipidus in the setting of underlying chronic nephrogenic diabetes insipidus associated with lithium use.

lithium

Transient central diabetes insipidus

associated


Input: A macrophage activation syndrome, possibly related to methotrexate toxicity, developed in a boy with systemic juvenile rheumatoid arthritis.

macrophage activation syndrome

methotrexate toxicity

a boy with systemic juvenile rheumatoid arthritis

possibly

developed


Input: Hyponatremia in patients treated with lorcainide, a new antiarrhythmic drug.

lorcainide

Hyponatremia

patients

treated


Input: Electrical proarrhythmia with procainamide: a new ICD-drug interaction.

Electrical proarrhythmia

procainamide

with


Input: To report a case of QT prolongation associated with concomitant cyclobenzaprine and fluoxetine administration followed by torsade de pointes potentiated by droperidol.

QT prolongation

concomitant cyclobenzaprine and fluoxetine administration

associated

torsade de pointes

droperidol

potentiated


Input: It is presumed that her hyperchloremic metabolic acidosis was secondary to cholestyramine because of the similarity to pediatric reports; the rapid and lasting response to intravenous sodium bicarbonate; the absence of another etiology; normal serum potassium, chloride and bicarbonate despite continued spironolactone therapy after recovery.

hyperchloremic metabolic acidosis

cholestyramine

presumed

secondary


Input: Azathioprine can cause severe myelosuppression.

Azathioprine

severe myelosuppression

cause


Input: Secretory endometrial adenocarcinoma in a patient on tamoxifen for breast cancer: a report of a case.

tamoxifen for breast cancer

Secretory endometrial adenocarcinoma

a patient

on


Input: It was postulated that the allergic reaction was most likely caused by capecitabine or the intermediate metabolites based on the immediate reappearance of symptoms from the rechallenge, pharmacokinetic data, and well-tolerance of fluorouracil.

allergic reaction

capecitabine or the intermediate metabolite

postulated

caused


Input: Anterior lumbosacral radiculopathy after intrathecal methotrexate treatment.

intrathecal methotrexate

Anterior lumbosacral radiculopathy

after


Input: Divalproex sodium-induced eosinophilic pleural effusion.

Divalproex sodium

eosinophilic pleural effusion

induced


Input: A 26-year-old Japanese man, who had been receiving medical attention for ulcerative colitis for one year, presented with diffuse erythema and pustules on his face and trunk, malaise, and fever up to 39 degrees C one day after the administration of salazosulfapyridine.

diffuse erythema and pustules on his face and trunk, malaise, and fever up to 39 degrees C

A 26-year-old Japanese man, who had been receiving medical attention for ulcerative colitis for one year

salazosulfapyridine

after


Input: Amphotericin B-induced seizures in a patient with AIDS.

Amphotericin B

seizures

a patient with AIDS

induced


Input: Concomitant irradiation apparently enhanced the skin toxicity of aminoglutethimide or possibly aminoglutethimide had a radiosensitizing role in this patient.

this patient

skin toxicity

Concomitant irradiation

aminoglutethimide

enhanced


Input: CASE DESCRIPTION: A 59-year-old man with known neurocysticercosis developed a large cerebral infarction during praziquantel therapy.

A 59-year-old man with known neurocysticercosis

a large cerebral infarction

during praziquantel therapy

developed


Input: We describe a 73-year-old woman who developed serious systemic vasculitis with associated thrombocytopenia in the course of treatment with cladribine.

cladribine

systemic vasculitis with associated thrombocytopenia

a 73-year-old woman

developed


Input: All changes disappeared 4 months after the discontinuation of VAD chemotherapy, which further pointed out towards adriamycin and vincristine as possible etiologic agents.

All changes

adriamycin and vincristine

possible

etiologic agents


Input: Because of further progression combination treatment of bevacizumab and irinotecan was started and again no liver toxicity was observed.

bevacizumab and irinotecan

liver toxicity

no

observed


Input: Torsade de pointes represents a potential complication of chronic amiodarone therapy.

Torsade de pointes

chronic amiodarone therapy

potential

complication


Input: Eosinophilia caused by clozapine was observed in challenge, preceded by a faster neutrophil production and consecutive decrease (z = 2.27, p = 0.01).

Eosinophilia

preceded by a faster neutrophil production and consecutive decrease (z = 2.27, p = 0.01)

clozapine

caused


Input: The first case is a 69-year-old man who was admitted for depression with psychosis and treated with trazodone, risperidone, and sertraline.

a 69-year-old man who was admitted for depression with psychosis

trazodone, risperidone, and sertraline

treated


Input: Multiple complications of propylthiouracil treatment: granulocytopenia, eosinophilia, skin reaction and hepatitis with lymphocyte sensitization.

propylthiouracil

granulocytopenia, eosinophilia, skin reaction and hepatitis with lymphocyte sensitization

complications


Input: Whether concomitant fluvoxamine treatment reduces tacrine-induced hepatotoxicity needs further study.

tacrine

hepatotoxicity

induced

concomitant fluvoxamine

Whether

reduces


Input: Severe hyperkalemia occurred in a patient with radiation pneumonitis and glaucoma shortly after beginning prednisone therapy.

Severe hyperkalemia

a patient with radiation pneumonitis and glaucoma

prednisone

Severe

after


Input: She was treated with Pancrease MT 16, but had consistent vomiting 1 to 2 hours after administration of enzymes.

vomiting

enzymes

after


Input: Following are two clinical case reports demonstrating profound cerebral edema associated with implantation of Gliadel wafers.

profound cerebral edema

implantation of Gliadel wafers

two clinical case

profound

associated


Input: At this point, a new antifungal agent had been commenced, suggesting a possible drug interaction enhancing the risk of known neurological toxicity with this regime.

a new antifungal agent

a possible drug interaction enhancing the risk of known neurological toxicity with this regime

suggesting


Input: The knowledge concerning VGB-associated visual dysfunction in pediatric patients, particularly in those who have been exposed to VGB in utero is limited.

VGB

visual dysfunction

pediatric patients

associated


Input: We herein described an additional patient with BCR-ABL (ela2) positive acute lymphoblastic leukemia who developed tumor lysis syndrome after 10-day treatment with imatinib.

patient with BCR-ABL (ela2) positive acute lymphoblastic leukemia

tumor lysis syndrome

10-day treatment with imatinib

developed


Input: Tubulointerstitial nephritis induced by the leukotriene receptor antagonist pranlukast.

Tubulointerstitial nephritis

pranlukast

induced


Input: Two drugs commonly used in triple-drug therapy for treatment of a Helicobacter pylori infection, clarithromycin and omeprazole, have rarely been associated with hypoglycemia when given alone.

clarithromycin and omeprazole

hypoglycemia

associated


Input: We describe the infectious toxicities experienced by the first two patients in our institution treated with dexamethasone (10 mg/m(2)/day for 4 weeks with gradual tapering) during induction according to the dexamethasone arm of BFM 2000 and review the relevant literature that suggests an increased risk of infectious complications with dexamethasone.

infectious toxicities

first two patients in our institution

treated with dexamethasone (10 mg/m(2)/day for 4 weeks with gradual tapering) during induction according to the dexamethasone arm of BFM 2000

experienced by


Input: This case demonstrates that there is no cross reactivity between glyburide and chlorpropamide in producing hemolytic anemia.

hemolytic anemia

glyburide and chlorpropamide

no cross reactivity

producing


Input: Codeine intoxication in the neonate.

Codeine

Codeine intoxication

neonate

in


Input: However, 1 eye had vitreous hemorrhage after repeated injections of tPA.

repeated injections of tPA

1 eye had vitreous hemorrhage

after


Input: Dilated cardiomyopathy associated with chronic overuse of an adrenaline inhaler.

Dilated cardiomyopathy

chronic overuse of an adrenaline inhaler

associated


Input: Surgeons and physicians should therefore be aware of the potential for RTA to occur with FK506 after any organ transplantation.

RTA

FK506 after any organ transplantation

potential

occur


Input: Thirty patients with hepatic reactions to cyclofenil, a non-steroidal drug with a stimulating effect on ovulation, are reviewed.

Thirty patients

hepatic

cyclofenil

reactions


Input: Though serotonin syndrome is most often associated with ingestion of more than one serotonergic drug, many other mechanisms have been associated with serotonergic excess.

serotonin syndrome

ingestion of more than one serotonergic drug

associated with


Input: Because of a hypersensitivity reaction, initial therapy with penicillin G and gentamicin was stopped and substituted with cefazolin.

hypersensitivity reaction

penicillin G

gentamicin

with


Input: Ophthalmologists should be aware of the ocular side effects of IFN therapy and carefully monitor patients for the possible occurrence of hypoalbuminemia and thrombocytopenia.

ocular side effects

hypoalbuminemia and thrombocytopenia

IFN

patients

possible

aware


Input: The third patient had been suffering from serious akathisia while on risperidone, and was cured after switching to olanzapine, but thereafter the patient suffered from RLS at nighttime.

The third patient

akathisia

risperidone

serious

suffering

The third patient

switching to olanzapine

RLS at nighttime

suffered


Input: Chlorpropamide-induced hemolytic anemia.

Chlorpropamide

hemolytic anemia

induced


Input: We report recrudescence of imported Plasmodium falciparum malaria following quinine treatment in the context of concurrent phenytoin use.

Plasmodium falciparum malaria

quinine treatment in the context of concurrent phenytoin use

following


Input: It is likely that RA contributed to the deterioration in renal function in these patients.

RA

deterioration in renal function

likely

contributed


Input: Marked sinus tachycardia resulting from the synergistic effects of marijuana and nortriptyline.

Marked sinus tachycardia

marijuana and nortriptyline

resulting


Input: Infliximab and its serious adverse effects are discussed, and other cases of osteomyelitis with infliximab use are also reviewed.

osteomyelitis

infliximab

serious

with


Input: A new type of minocycline-induced cutaneous hyperpigmentation.

minocycline

cutaneous hyperpigmentation

induced


Input: Stroke is an infrequent but recognized complication of heroin addiction.

Stroke

heroin addiction

recognized

complication


Input: Although this type of hyperpigmentation has been previously seen in patients with cancer who are receiving bleomycin, this is, to our knowledge, the first reported case of bleomycin-induced hyperpigmentation in an AIDS patient and should be added to the growing list of cutaneous eruptions seen in these patients.

bleomycin

an AIDS patient

hyperpigmentation

to our knowledge

induced


Input: Case report of withdrawal dyskinesia associated with amoxapine.

withdrawal dyskinesia

amoxapine

Case

associated


Input: Concern exists that preadmission warfarin use may be associated with an increased risk of intracerebral hemorrhage in patients with ischemic stroke receiving intravenous tissue plasminogen activator, even in those with an international normalized ratio <1.7.

increased risk of intracerebral hemorrhage

receiving intravenous tissue plasminogen activator

preadmission warfarin

patients with ischemic stroke

may be associated with an increased risk

associated


Input: Transient anuria following administration of angiotensin I-converting enzyme inhibitor (SQ 14225) in a patient with renal artery stenosis of the solitary kidney successfully treated with renal autotransplantation.

angiotensin I-converting enzyme inhibitor (SQ 14225)

a patient with renal artery stenosis of the solitary kidney

Transient anuria

following

a patient with renal artery stenosis of the solitary kidney

renal autotransplantation

treated


Input: Development of essential thrombocythemia in a patient treated with interferon alfa and pentostatin for hairy cell leukemia.

a patient

essential thrombocythemia

interferon alfa and pentostatin

Development


Input: A case of SIADH induced by mizoribin administration.

mizoribin administration

SIADH

A case

induced


Input: The agranulocytosis was rapidly resolved by granulocyte colony-stimulating factor (G-CSF) therapy and by the discontinuation of vancomycin.

agranulocytosis

granulocyte colony-stimulating factor (G-CSF) therapy and by the discontinuation of vancomycin

resolved


Input: A patient that received methadone for cancer-associated pain developed myoclonus as a side effect.

A patient

methadone

myoclonus

developed


Input: These cases were considered unusual in light of the short delay of their onset after initiation of immunosuppressive therapy and their fulminant course: 3 of these patients died of PCP occurring during the first month of treatment with prednisone.

3 of these patients

PCP

first month of treatment with prednisone

died


Input: Five days after the fourth dose of vincristine, she presented with bilateral ptosis.

bilateral ptosis

she

Five days after the fourth dose of vincristine

presented


Input: As it had been 10 months since her last dosage adjustment of diltiazem, it was unlikely that the statin-induced rhabdomyolysis was precipitated by diltiazem.

statin-induced rhabdomyolysis

diltiazem

unlikely

unlikely

precipitated


Input: After the chlorambucil was discontinued, the wbc count began to slowly rise and the patient developed clinical AML.

chlorambucil

wbc count began to slowly rise

clinical AML

the patient

developed


Input: She received 3.8 mg cumulative dose of vincristin before development of ptosis.

3.8 mg cumulative dose of vincristin

ptosis

She

development


Input: In addition, the tachycardia persisted and was repeatedly spontaneously reinitiated for prolonged periods after procainamide.

procainamide

tachycardia persisted and was repeatedly spontaneously reinitiated for prolonged periods

after


Input: One patient had a lower average heart rate and two patients had lower average mean blood pressure values during propranolol treatment, none of which was clinically significant.

two patients

lower average mean blood pressure values

propranolol

none of which was clinically significant

during

propranolol

One patient

lower average heart rate

during


Input: We have successfully overcome severe neutropenia in an RA patient treated with gold salts, using granulocyte colony-stimulating factor (G-CSF), reducing the duration of neutropenia and risk of infection.

an RA patient treated with gold salts

granulocyte colony-stimulating factor (G-CSF)

reducing the duration of neutropenia and risk of infection

overcome

severe neutropenia

gold salts

in


Input: A third patient experienced disabling neurotoxicity in the extremity of a prior ulnar nerve and tendon transposition after receiving paclitaxel.

A third patient

paclitaxel

disabling neurotoxicity in the extremity of a prior ulnar nerve and tendon transposition

experienced


Input: While 40 mg/day of prednisolone improved hepatic dysfunction dramatically, her diabetic milieu deteriorated seriously.

40 mg/day of prednisolone

diabetic milieu deteriorated

seriously

deteriorated

40 mg/day of prednisolone

improved


Input: Acute renal insufficiency is known to occur in patients who are taking ciprofloxacin, particularly the elderly.

Acute renal insufficiency

patients

elderly

ciprofloxacin

occur


Input: A 61-year-old man developed clinical lupus syndrome with positive antinuclear antibody, positive lupus erythematosus (LE) cell preparation, and diffuse proliferative glomerulonephritis following 26 months of procainamide therapy.

61-year-old man

clinical lupus syndrome with positive antinuclear antibody, positive lupus erythematosus (LE) cell preparation, and diffuse proliferative glomerulonephritis

26 months of procainamide therapy

developed


Input: We report the successful treatment of heparin-induced thrombocytopenia and subsequent hemorrhagic complications postoperatively in a 2-year-old child with Danaparoid (orgaran).

heparin

thrombocytopenia and subsequent hemorrhagic complications

a 2-year-old child

induced

a 2-year-old child

Danaparoid (orgaran)

treatment


Input: Laryngeal dyspnea in relation to an interaction between acenocoumarol and topical econazole lotion.

Laryngeal dyspnea

acenocoumarol

topical econazole lotion

relation


Input: A 46-year old man with a chronic hepatitis C virus infection received triple therapy with ribavirin, pegylated interferon and telaprevir.

A 46-year old man with a chronic hepatitis C virus infection

triple therapy with ribavirin, pegylated interferon and telaprevir

received


Input: Leishmania infantum leishmaniasis in corticosteroid--treated patients.

Leishmania infantum leishmaniasis

corticosteroid

treated


Input: The patient developed occipital infarcts and was found to have extremely elevated levels of PPA in his blood and dialysis fluid.

The patient

occipital infarcts

extremely elevated levels of PPA

developed


Input: As atypical antipsychotics are increasingly used in the treatment of childhood behavioural disorders either as monotherapy or in combination with other medications, there is a need to know more about their safety, in particular during switching to and from methylphenidate treatment, as antipsychotics and methylphenidate have opposing effects on dopaminergic neurotransmission.

atypical antipsychotics

as monotherapy or in combination with other medications

treatment


Input: Sensory neuropathy revealing necrotizing vasculitis during infliximab therapy for rheumatoid arthritis.

infliximab therapy

Sensory neuropathy revealing necrotizing vasculitis

during


Input: Because etoposide-induced pulmonary toxicity is an uncommon but serious adverse event, clinicians must be vigilant about the possibility of it, so that the optimal treatment can start as soon as possible.

etoposide

pulmonary toxicity

induced


Input: On March 13 the patient was again admitted for worsening CHF and was started on continuous dobutamine infusion.

the patient was again admitted for worsening CHF

continuous dobutamine infusion

started on


Input: Suspected methotrexate toxicity from omeprazole: a case review of carboxypeptidase G2 use in a methotrexate-experienced patient with methotrexate toxicity and a review of the literature.

methotrexate toxicity

omeprazole

Suspected

from

methotrexate

toxicity

toxicity

methotrexate-experienced patient

carboxypeptidase G2

use


Input: We report a 53-year-old-man who developed rippling muscle disease (RMD) 2 months after starting simvastatin therapy for hypercholesterolemia.

a 53-year-old-man

rippling muscle disease (RMD)

2 months after starting simvastatin therapy

developed


Input: After taking cholestyramine II sachets twice daily for two months she presented with lethargy, confusion and drowsiness.

cholestyramine II sachets twice daily for two months

lethargy, confusion and drowsiness

she

After


Input: Escape atrial complexes, which occurred following junctional premature complexes, failed to initiate tachycardia in the control state but tachycardia was always reinitiated by an identical escape sequence after procainamide.

procainamide

tachycardia

reinitiated


Input: Ten percent of newly diagnosed myeloma patients treated with any type of chemotherapy develop deep venous thrombosis (DVT).

myeloma patients

any type of chemotherapy

deep venous thrombosis (DVT)

develop


Input: In summary, we report herein the first case of SIADH believed to be an adverse effect of mizoribin, which may therefore needed to be added to the list of drugs which can induce SIADH.

mizoribin

SIADH

the first case

believed

adverse effect


Input: Isoniazid and ethambutol as a cause of optic neuropathy.

optic neuropathy

Isoniazid and ethambutol

cause


Input: Fluorouracil for allergic reactions to capecitabine.

allergic reactions

capecitabine

to

Fluorouracil

for


Input: Administration of pyridoxine to an infant after a long period of convulsions was followed by acute hypotonia.

pyridoxine

an infant

acute hypotonia

followed


Input: Acute pancreatitis in a child with idiopathic ulcerative colitis on long-term 5-aminosalicylic acid therapy.

Acute pancreatitis

a child with idiopathic ulcerative colitis

long-term 5-aminosalicylic acid therapy

in


Input: High-dose antithrombin III in severe sepsis: a randomized controlled trial.

High-dose antithrombin III

in


Input: Fatal interstitial pneumonitis following high-dose intermittent chlorambucil therapy for chronic lymphocyte leukemia.

Fatal interstitial pneumonitis

high-dose intermittent chlorambucil therapy

Fatal

following


Input: These findings suggest that the corneal and retinal changes are the result of a toxic effect of tamoxifen when used in the doses and duration described.

tamoxifen

corneal and retinal changes

result


Input: Common adverse events (frequency 10%) of lacosamide doses up to 600 mg/day include nonspecific central nervous system effects (e.g., dizziness, ataxia, diplopia, and somnolence).

lacosamide doses up to 600 mg/day

nonspecific central nervous system effects (e.g., dizziness, ataxia, diplopia, and somnolence)

include


Input: We report two cases of serotonin syndrome in elderly patients during treatment of psychotic depression with atypical antipsychotics and antidepressants.

serotonin syndrome

elderly patients

atypical antipsychotics and antidepressants

during


Input: Piritrexim-induced pulmonary toxicity.

Piritrexim

pulmonary toxicity

induced


Input: Progression of chronic myeloid leukemia to blast crisis during treatment with imatinib mesylate.

Progression of chronic myeloid leukemia to blast crisis

imatinib mesylate

blast crisis

during


Input: Presentation of three palliative care patients who were given ketamine as an analgesic and subsequently developed significant and debilitating urological symptoms.

three palliative care patients

ketamine

urological symptoms

significant and debilitating

developed


Input: A 52 year-old male patient diagnosed of ankylosing spondylitis presented with an iron deficiency anemia after a ten-month treatment of methotrexate.

A 52 year-old male patient diagnosed of ankylosing spondylitis

an iron deficiency anemia

a ten-month treatment of methotrexate

presented


Input: The international literature regarding opportunistic infections after immunosuppressive therapy with alemtuzumab with particular attention on fungal infections has also been reviewed.

opportunistic infections

immunosuppressive therapy with alemtuzumab

after


Input: Clinicians should be aware of the dysrhythmic potential of cyclobenzaprine and fluoxetine, monitor for other cytochrome P450 inhibitors, and avoid concomitant drugs known to prolong the QT interval.

dysrhythmic

cyclobenzaprine and fluoxetin

potential

potential


Input: Acute generalized exanthematous pustulosis induced by salazosulfapyridine in a patient with ulcerative colitis.

Acute generalized exanthematous pustulosis

salazosulfapyridine

a patient with ulcerative colitis

induced


Input: CONCLUSION: Acetic acid is corrosive and may cause vagina bleeding.

Acetic acid

vagina bleeding

may

cause


Input: We report a case admitted with a first-detected, symptomatic paroxysmal atrial fibrillation in a healthy patient after self-medication with vardenafil.

a healthy patient

vardenafil

symptomatic paroxysmal atrial fibrillation

after


Input: Propranolol: an unrecognized cause of central nervous system dysfunction in patients undergoing cardiopulmonary bypass.

Propranolol

central nervous system dysfunction

patients undergoing cardiopulmonary bypass

cause


Input: CONCLUSIONS: Symptoms and pathologic changes of colitis are associated with exposure to rofecoxib.

Symptoms and pathologic changes of colitis

rofecoxib

associated with


Input: A possible drug-drug interaction between IFN alfa 11 MU TIW and gemfibrozil 600 mg BID was reported in a patient undergoing treatment for IFN-induced hypertriglyceridemia.

drug-drug interaction between IFN alfa 11 MU TIW and gemfibrozil 600 mg BID

a patient

IFN-induced hypertriglyceridemia

possible

reported


Input: Systemic vasculitis complicating hairy cell leukaemia treatment with cladribine.

cladribine

Systemic vasculitis

treatment


Input: Quinine is universally used for the very common symptom of night leg cramps.

Quinine

universally

used


Input: However, continued low-dose MTX led, in spite of normal liver tests, 8 years after the last biopsy to liver failure and death in 1 of our patients.

liver failure and death

low-dose MTX

led


Input: Antithrombin III may provide protection from multiorgan failure and improve survival in severely ill patients.

severely ill patients

Antithrombin III

multiorgan failure

may

provide protection


Input: In the second case, five cardiac arrests due to ventricular tachycardia and fibrillation occurred during several hours after beginning a trial of bretylium maintenance therapy for complex ventricular ectopy.

several hours after beginning a trial of bretylium maintenance therapy

five cardiac arrests due to ventricular tachycardia and fibrillation

In the second case

occurred


Input: The association of central diabetes insipidus (CDI) with lithium use is rare.

central diabetes insipidus (CDI)

lithium

association


Input: However, a new episode of neutropenia, with a WBC count of 2.8 x 10(3)/mm3 and ANC of 0.448 x 10(3)/mm3, occurred 11 days after teicoplanin initiation.

neutropenia, with a WBC count of 2.8 x 10(3)/mm3 and ANC of 0.448 x 10(3)/mm3

11 days after teicoplanin initiation

occurred


Input: In a phase II study of hycanthone in patients with breast cancer we have recently observed severe hepatotoxicity, even at lower doses, which resulted in two drug-related deaths.

hycanthone

patients with breast cancer

hepatotoxicity

deaths

observed


Input: This is the first report of non-convulsive status epilepticus provoked by tiagabine in adolescent patients.

non-convulsive status epilepticus

tiagabine

adolescent patients

provoked


Input: Two patients are described who developed sensory neuropathy after the ingestion of 30.6 and 114 g metronidazole respectively.

the ingestion of 30.6 and 114 g metronidazole

Two patients

sensory neuropathy

after


Input: We report two young patients with cystic fibrosis who presented with acute renal insufficiency after 2-3 weeks of oral ciprofloxacin therapy.

acute renal insufficiency

2-3 weeks of oral ciprofloxacin therapy

two young patients with cystic fibrosis

presented


Input: A 37-year-old male with multiple myeloma received citalopram 40 mg/day and trazodone 150 mg/day for anxiety-related disorders.

A 37-year-old male with multiple myeloma

citalopram 40 mg/day and trazodone 150 mg/day

for


Input: Hashimoto's disease during interferon-alpha therapy in a patient with pre-treatment negative anti-thyroid autoantibodies and with the specific genetic susceptibility to the thyroid disease.

a patient with pre-treatment negative anti-thyroid autoantibodies and with the specific genetic susceptibility to the thyroid disease

Hashimoto's disease

interferon-alpha

during


Input: Fever, lymphadenopathy, eosinophilia, lymphocytosis, hepatitis, and dermatitis: a severe adverse reaction to minocycline.

Fever, lymphadenopathy, eosinophilia, lymphocytosis, hepatitis, and dermatitis

minocycline

adverse reaction


Input: CONCLUSIONS: This observation of "on-off" risperidone treatment suggests that risperidone may have worsened both psychiatric and physical manifestations of the mitochondrial disorder in this adolescent.

risperidone

psychiatric and physical manifestations

mitochondrial disorder in this adolescent

may

have worsened


Input: The events of non-convulsive status epilepticus subsided following reduction in tiagabine dosages.

reduction in tiagabine dosages

non-convulsive status epilepticus subsided

following


Input: CONCLUSIONS: For all patients with vancomycin-induced neutropenia, possible cross-reactivity of teicoplanin should be monitored.

vancomycin

neutropenia

patients

induced


Input: Methotrexate induced sprue-like syndrome.

Methotrexate

sprue-like syndrome

induced


Input: Because of the described effects of niacin on the coagulation cascade and the possibility for pharmacokinetic interactions, there is a potential for synergistic coagulopathy when combined with warfarin therapy.

synergistic coagulopathy

niacin

combined with warfarin therapy

potential

potential


Input: The failure of therapy with disopyramide and mexiletine to reproduce this observation suggests either a previously unreported electrophysiologic effect of, or idiosyncratic response to, procainamide.

electrophysiologic effect

procainamide

failure

response


Input: The former patient had complained once that his visual acuity had decreased after the termination of IFN therapy, and the latter patient complained twice during IFN therapy that his visual acuity had decreased.

visual acuity had decreased

IFN

The former patient

after

patient

IFN therapy

visual acuity had decreased

during


Input: Despite administration of phenytoin and lorazepam, the seizures persisted and occurred only during amphotercin B administration.

amphotercin B

seizures

during


Input: We describe a patient who presented with bloody diarrhoea after 15 mg meloxicam daily for 10 days for osteoarthritis.

a patient who presented with bloody diarrhoea

osteoarthritis

bloody diarrhoea

15 mg meloxicam daily for 10 days

after


Input: In the first patient, two episodes of ventricular tachycardia requiring cardioversion occurred in close temporal sequence with administering bretylium.

first patient

close temporal sequence with administering bretylium

two episodes of ventricular tachycardia requiring cardioversion

occurred


Input: Transient phenytoin induced IgA deficiency and permanent IgE increase.

phenytoin

IgA deficiency and permanent IgE increase

permanent

induced


Input: Cerebral edema associated with Gliadel wafers: two case studies.

Cerebral edema

Gliadel wafers

associated


Input: Following the development of restless leg syndrome, therapy with clonazepam 0.5 mg qhs was initiated.

clonazepam 0.5 mg qhs

therapy


Input: We present a case of a diabetic patient taking glyburide who was prescribed ciprofloxacin and developed prolonged hypoglycemia, which persisted for over 24 hours.

a case of a diabetic patient taking glyburide

prolonged hypoglycemia, which persisted for over 24 hours

ciprofloxacin

developed


Input: We describe a 74-year-old man with rheumatoid arthritis (RA) who developed syndrome of inappropriate secretion of antidiuretic hormone (SIADH) 1.5 months after commencement of mizoribin prescription when his arthritis was improved.

a 74-year-old man with rheumatoid arthritis (RA)

syndrome of inappropriate secretion of antidiuretic hormone (SIADH)

1.5 months after commencement of mizoribin prescription

developed


Input: To our knowledge, this is the first case of ivermectin-induced severe liver disease published in the literature.

ivermectin

severe liver disease

severe

induced


Input: This is the first case of hydroxyurea-induced acute interstitial pneumonitis reported in the literature.

hydroxyurea

acute interstitial pneumonitis

induced


Input: A 32-year-old man with a family history of type 2 diabetes mellitus presented with circulatory collapse and deep coma after 9 days of treatment with perospirone hydrochloride, a recently developed atypical antipsychotic agent available only in Japan.

9 days of treatment with perospirone hydrochloride

circulatory collapse and deep coma

A 32-year-old man with a family history of type 2 diabetes mellitus

after


Input: CONCLUSION: The chronic use of HCQ for rheumatic diseases, or as an anti-malarial drug, should be balanced against the risk of developing potentially lethal cardiac arrhythmias.

lethal cardiac arrhythmias

chronic use of HCQ

risk of developing potentially

against


Input: Myoclonic spasms following intrathecal morphine.

Myoclonic spasms

intrathecal morphine

following


Input: This is the first report of a disulfiram-like reaction with cefmenoxime.

disulfiram-like reaction

cefmenoxime

with


Input: To report a case of a probable interaction between warfarin and extended-release niacin that may have led to synergistic coagulopathy and to inform health care providers of a need for more frequent monitoring of international normalized ratio (INR) in patients taking these drugs concomitantly.

warfarin and extended-release niacin

synergistic coagulopathy

may

led


Input: Dasatinib-induced pleural effusions: a lymphatic network disorder?

Dasatinib

pleural effusions

induced


Input: This article reports the case of an otherwise healthy patient who experienced permanent sensorineural hearing loss after a brief course of naproxen and reviews the literature on NSAID-related permanent sensorineural hearing loss.

an otherwise healthy patient

permanent sensorineural hearing loss

a brief course of naproxen

after


Input: Administration of steroid and decreasing the dose of PTU produced a good clinical response and the ANCA disappeared.

steroid

PTU

a good clinical response and the ANCA disappeared

produced


Input: The second patient exhibited sudden PLMS following olanzapine injection.

The second patient

sudden PLMS

olanzapine injection

following


Input: However, adenosine shortens the antegrade refractoriness of accessory atrioventricular connections and may cause acceleration of the ventricular rate during atrial fibrillation.

adenosine

acceleration of the ventricular rate during atrial fibrillation

cause


Input: A cardiology consultation performed on the day of admission determined that a markedly elevated creatine kinase-myocardial band isoenzyme level and borderline-high troponin I level were diagnostic of rhabdomyolysis secondary to statin use.

elevated creatine kinase-myocardial band isoenzyme level and borderline-high troponin I level

rhabdomyolysis

statin

secondary


Input: METHODS: Double-blind, placebo-controlled titrated oral challenges with pancreatic enzymes resulted in definite vomiting within 1 to 1.5 hours after challenges with Viokase and Pancrease MT 16, but not with placebo.

Viokase and Pancrease MT 16

vomiting

resulted in


Input: Abiraterone acetate, an androgen biosynthesis inhibitor, prolongs survival in men with metastatic castration-resistant prostate cancer (mCRPC) in the pre- and post-chemotherapy setting as demonstrated by the pivotal phase III studies COU-AA-301 and COU-AA-302.

men with metastatic castration-resistant prostate cancer (mCRPC)

Abiraterone acetate, an androgen biosynthesis inhibitor

prolongs survival


Input: Reduction of methylprednisolone dosage rather than insulin therapy resulted in better control of glycemia.

Reduction of methylprednisolone dosage rather than insulin therapy

resulted


Input: Here, we report a case of RFP-induced hypothyroidism without underlying thyroid disease.

RFP

hypothyroidism without underlying thyroid disease

induced


Input: Here we report ramipril-induced cutaneous vasculitis in a patient who required steroid therapy to control it.

ramipril

cutaneous vasculitis

a patient

induced


Input: A 78-year-old man with a transvenous cardioverter defibrillator system developed frequent shocks during oral procainamide therapy.

frequent shocks

during oral procainamide therapy

A 78-year-old man with a transvenous cardioverter defibrillator system

developed


Input: A 53 year old Greenlandic male was admitted twice over a period of 4 years with a new complete right bundle branch block after ingestion of 10 g and 4 g of carbamazepine respectively.

A 53 year old Greenlandic male

ingestion of 10 g and 4 g of carbamazepine

was admitted twice over a period of 4 years with a new complete right bundle branch block

after


Input: In contrast, other common agents for the most part trigger cutaneous inflammation.

other common agents for the most part

cutaneous inflammation

trigger


Input: In both patients the rippling phenomena worsened with pyridostigmine treatment but markedly improved after immunosuppression with azathioprine.

pyridostigmine

rippling phenomena

both patients

worsened


Input: We present findings from three patients who experienced a psoriasiform eruption apparently due to the antiepileptic agents sodium valproate and carbamazepine.

three patients

psoriasiform eruption

antiepileptic agents sodium valproate and carbamazepine

apparently

due to


Input: We report here such a case with bilateral Mooren's ulcer that failed to respond to local therapy with topical corticosteroids, silver nitrate, and conjunctival resection, as well as systemic immunosuppression with corticosteroids, cyclophosphamide, and azathioprine.

local therapy with topical corticosteroids, silver nitrate, and conjunctival resection, as well as systemic immunosuppression with corticosteroids, cyclophosphamide, and azathioprine

a case with bilateral Mooren's ulcer

failed

respond


Input: Successful treatment with carbimazole of a hyperthyroid pregnancy with hepatic impairment after propylthiouracil administration: a case report.

carbimazole

Successful treatment

propylthiouracil

a hyperthyroid pregnancy with hepatic impairment

after


Input: Jaundice induced by streptokinase.

Jaundice

streptokinase

induced


Input: When thrombosis develops during heparin treatment, it is important to suspect HITTs and to assay for the associated antibodies, regardless of the actual platelet count.

heparin

thrombosis

HITTs

suspect

develops


Input: The results in this case suggest that cyclosporin is an effective agent in patients with severe sight threatening Mooren's ulcer.

cyclosporin

patients with severe sight threatening Mooren's ulcer

is an effective agent

suggest

effective


Input: CONCLUSIONS: Amphotericin B overdose can be fatal in children and infants.

Amphotericin B overdose

children and infants

fatal

be


Input: Five and one-half years after the diagnosis of myeloma, while in remission on cyclophosphamide therapy, the patient experienced severe abdominal right lower quadrant pain due to a large cecal lymphoma.

cyclophosphamide therapy

diagnosis of myeloma

patient

severe abdominal right lower quadrant pain

large cecal lymphoma

severe

experienced


Input: Leukaemoid monocytosis in M4 AML following chemotherapy and G-CSF.

Leukaemoid monocytosis in M4 AML

chemotherapy and G-CSF

following


Input: Vitiligo associated with alpha-interferon in a patient with chronic active hepatitis C.

Vitiligo

alpha-interferon

a patient with chronic active hepatitis C

associated


Input: We report a case of fulminant neuroleptic malignant syndrome in a man aged 70 developing within 12 hours of starting six-hourly intravenous metoclopramide.

fulminant neuroleptic malignant syndrome

a man aged 70

six-hourly intravenous metoclopramide

developing


Input: CASE PRESENTATION: We report a patient with CF who developed recurrent eosinophilia and severe persistent bronchospasm following repeated administration of preservative-free tobramycin by inhalation, beginning at 16 months of age.

a patient with CF

beginning at 16 months of age

recurrent eosinophilia and severe persistent bronchospasm

repeated administration of preservative-free tobramycin by inhalation

developed


Input: Ballistic movements due to ischemic infarcts after intravenous heroin overdose: report of two cases.

Ballistic movements due to ischemic infarcts

intravenous heroin overdose

two cases

after


Input: A case of barbiturate-induced submassive hepatic necrosis is presented and the literature is reviewed.

barbiturate

submassive hepatic necrosis

A case

induced


Input: With combined use, clinicians should be aware, when phenytoin is added, of the potential for reexacerbation of pulmonary symptomatology due to lowered serum theophylline concentrations.

phenytoin is added

theophylline

reexacerbation of pulmonary symptomatology

potential

due


Input: Fluoxetine-induced akathisia: clinical and theoretical implications.

Fluoxetine

akathisia

induced


Input: Lansoprazole-associated collagenous colitis: a case report.

Lansoprazole

collagenous colitis

associated


Input: We discuss a variety of bronchopulmonary complications of IBD and their association with sulfasalazine.

sulfasalazine

a variety of bronchopulmonary complications of IBD

discuss

association


Input: OBJECTIVE: To report the late development of immune-mediated diabetes mellitus after completion of alfa-interferon therapy for hepatitis C in an Asian patient.

alfa-interferon

an Asian patient

the late development of immune-mediated diabetes mellitus

after


Input: The tirapazamine-plus-cisplatin regimen was associated with mild to moderate adverse events, including acute, reversible hearing loss, reversible, intermittent muscle cramping, diarrhea, skin rash, nausea, and vomiting.

tirapazamine-plus-cisplatin regimen

mild to moderate adverse events, including acute, reversible hearing loss, reversible, intermittent muscle cramping, diarrhea, skin rash, nausea, and vomiting

associated


Input: To the best of our knowledge, corneoscleral melting in the first postoperative week after a single intraoperative application of mitomycin C has not been reported.

corneoscleral melting

a single intraoperative application of mitomycin C

not

after


Input: Thrombo-embolic complication after streptokinase therapy of pulmonary emboli.

Thrombo-embolic complication

streptokinase

after


Input: Amebic abscess of the spleen complicated by metronidazole-induced neurotoxicity: case report.

metronidazole

neurotoxicity

Amebic abscess of the spleen complicated

case

induced


Input: Subfulminant hepatitis B after infliximab in Crohn's disease: need for HBV-screening?

Subfulminant hepatitis B

infliximab

after


Input: Disseminated salmonellosis in a patient treated with temozolomide.

Disseminated salmonellosis

a patient

temozolomide

in


Input: The aim of our paper was to describe hepatotoxicity of sirolimus (SRL) in a kidney graft recipient.

sirolimus (SRL)

a kidney graft recipient

hepatotoxicity

in


Input: Idiosyncratic pulmonary reactions to nitrofurantoin are not unusual, often presenting as eosinophilic pneumonia.

Idiosyncratic pulmonary reactions

eosinophilic pneumonia

nitrofurantoin

not unusual

to


Input: The NZ Pharmacovigilance Centre has received 7 additional reports of severe infections in patients with RA taking leflunomide.

leflunomide

patients with RA

severe infections

severe

taking


Input: In addition, loading with one low oral dose of serine produced psychotic symptoms 5 h later which lasted 3-6 h.

one low oral dose of serine

5 h later

psychotic symptoms

loading


Input: Localized purpura associated with lamotrigine.

Localized purpura

lamotrigine

associated


Input: Aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension in a patient treated with trimethoprim-sulfamethoxazole.

a patient

trimethoprim-sulfamethoxazole

Aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension

in


Input: Torsemide appears to also be a part of a long list of agents that can cause pancreatitis.

Torsemide

pancreatitis

can

cause


Input: Sulfasalazine has been associated with bronchopulmonary complications of inflammatory bowel disease (IBD) in adults.

Sulfasalazine

bronchopulmonary complications of inflammatory bowel disease (IBD)

adults

associated


Input: Hydroxyurea-induced acute interstitial pneumonitis in a patient with essential thrombocythemia.

interstitial pneumonitis

Hydroxyurea

a patient with essential thrombocythemia

acute

induced


Input: The reported case represents an unusual association between medication with the proton pump inhibitor lansoprazole and the development of collagenous colitis suggesting the importance of evaluation of drug use in patients with microscopic colitis.

collagenous colitis

patients with microscopic colitis

proton pump inhibitor lansoprazole

association


Input: The temporal sequence of the respiratory insufficiency and the histopathology, when compared to the previous examples in the literature, suggest that cyclophosphamide was aetiologically responsible for the lung disease.

cyclophosphamide

lung disease

responsible


Input: A 57-year-old man developed chronic, watery diarrhea four weeks after Helicobacter pylori eradication therapy including lansoprazole followed by lansoprazole monotherapy for gastroesophageal reflux disease.

57-year-old man

chronic, watery diarrhea

four weeks after Helicobacter pylori eradication therapy including lansoprazole followed by lansoprazole monotherapy for gastroesophageal reflux disease

developed


Input: We believe that this represents an unusual case of moderate-dose MTX-induced neurotoxicity in a patient with gastric cancer, which has not previously been reported.

patient with gastric cancer

moderate-dose MTX

neurotoxicity

unusual

induced


Input: The patient expired after seven cycles of treatment had been completed because of pulmonary fibrosis and the drug toxicity of bleomycin.

seven cycles of treatment

drug toxicity of bleomycin

The patient

expired

after


Input: A statistical association between the incidence of DVT and combination chemotherapy including doxorubicin (P =.02) was observed; this association was confirmed on multivariate analysis.

DVT

combination chemotherapy including doxorubicin (P =.02)

confirmed

association


Input: Bleomycin pneumonitis potentiated by oxygen administration.

Bleomycin pneumonitis

oxygen administration

potentiated

by


Input: After five and six weeks of continuous oral administration of methylprednisolone, the boys developed steroid diabetes.

After five and six weeks of continuous oral administration of methylprednisolone

steroid diabetes

boys

developed


Input: CONCLUSION: This report describes a case of a probable interaction between topical econazole lotion 1% and acenocoumarol that resulted in overanticoagulation and a life-threatening laryngeal hematoma in this elderly patient.

a probable interaction between topical econazole lotion 1% and acenocoumarol

overanticoagulation and a life-threatening laryngeal hematoma

elderly patient

resulted


Input: Pulmonary lymphohistiocytic reactions temporally related to etanercept therapy.

Pulmonary lymphohistiocytic reactions

etanercept

related


Input: Disseminated tuberculous lesions post intravesical BCG therapy are rare but need to be identified and treated quickly.

Disseminated tuberculous lesions

BCG

post


Input: Rhabdomyolysis can occur with all statins when used alone and particularly when combined with other drugs that are themselves myotoxic or that elevate the concentration of the statin.

Rhabdomyolysis

statins

other drugs that are themselves myotoxic or that elevate the concentration of the statin

can

occur


Input: Amiodarone-induced dysthyroidism.

Amiodarone

dysthyroidism

induced


Input: Two patients with imminent gangrene of the extremities caused by ergot-induced arteriospasm underwent mechanical dilatation of the arteries when conventional measures such as anticoagulation, vasodilation, and sympathetic blockade produced no improvement.

ergot

arteriospasm

induced

ergot

imminent gangrene of the extremities

Two patients

caused


Input: Acute coronary syndromes can be associated with the infusion of rituximab.

Acute coronary syndromes

infusion of rituximab

associated


Input: Approximately 15 min after the first administration of nebulised morphine the patient became markedly bradypneic (respiratory rate: 4-5 bpm), hypotensive (BP 70/40 mmHg), and responded only partially to command.

nebulised morphine

patient

markedly bradypneic (respiratory rate: 4-5 bpm), hypotensive (BP 70/40 mmHg), and responded only partially to command

became


Input: Akathisia appeared to be a common side effect of fluoxetine and generally responded well to treatment with the beta-adrenergic antagonist propranolol, dose reduction, or both.

beta-adrenergic antagonist propranolol

responded


Input: An unusual cause of burn injury: unsupervised use of drugs that contain psoralens.

burn injury

use of drugs that contain psoralens.

cause


Input: The patient suffered a life-threatening anaphylactoid reaction to amifostine.

life-threatening anaphylactoid reaction

patient

amifostine

suffered


Input: We report three cases of severe hypocalcaemia associated with i.v. bisphosphonate treatment in patients with multiple myeloma.

severe hypocalcaemia

patients with multiple myeloma

i.v. bisphosphonate treatment

severe

associated


Input: We report a case of exfoliative dermatitis clearly linked to intravenous and intraperitoneal administration of tobramycin.

exfoliative dermatitis

a case

intravenous and intraperitoneal administration of tobramycin

linked


Input: Glomerulonephritis in procainamide induced lupus erythematosus: report of a case and review of the literature.

Glomerulonephritis

lupus erythematosus

procainamide

induced


Input: Patients treated with captopril who develop "atypical cholangitis" should be suspected of having captopril-associated liver damage.

Patients

atypical cholangitis

liver damage

captopril

suspected

associated


Input: We report a case of codeine intoxication in the neonate, in which the drug was prescribed for cough control during an emergency department visit.

codeine

in the neonate

for cough control during an emergency department visit

intoxication

prescribed


Input: Discontinuation of simvastatin and cyclosporine resulted in resolution of rhabdomyolysis and normalization of renal function.

Discontinuation of simvastatin and cyclosporine

normalization of renal function

resulted


Input: Phenylpropanolamine (PPA) recently has been publicly implicated as a cause of stroke and other neurologic events.

Phenylpropanolamine (PPA)

stroke and other neurologic events

cause


Input: Critically elevated INR in a patient on warfarin after increase in extended-release niacin dose.

a patient

elevated INR

warfarin

increase in extended-release niacin dose

Critically

after


Input: He developed severe hyperactivity and agitation on taking methylphenidate after the discontinuation of risperidone treatment.

He

hyperactivity and agitation

methylphenidate after the discontinuation of risperidone

severe

developed


Input: We suggest that objective evaluation of retinal function with electrophysiological methods should be performed in patients with visual disturbance during treatment with rifabutin.

rifabutin

visual disturbance

during


Input: A clinically atypical, neuropathologically verified case of Creutzfeldt-Jakob disease is described in a 32-year-old New Zealand woman with idiopathic hypopituitarism who had been treated in late adolescence (1970 to 1973) with human growth hormone processed from pooled cadaveric pituitary glands.

a 32-year-old New Zealand woman with idiopathic hypopituitarism

Creutzfeldt-Jakob disease

human growth hormone

described


Input: Quinine remains a reliable treatment for falciparum malaria in most parts of the world.

Quinine

treatment


Input: Severe corneal toxicity after topical fluoroquinolone therapy: report of two cases.

corneal toxicity

topical fluoroquinolone therapy

Severe

after


Input: She developed a generalized rash and itching, sore throat, and dizziness approximately 4 hours after the first dose of capecitabine.

a generalized rash and itching, sore throat, and dizziness

approximately 4 hours after the first dose of capecitabine

developed


Input: Seizures associated with fluoxetine therapy are uncommon.

Seizures

fluoxetine therapy

associated


Input: A 14-year-old girl with newly diagnosed SLE developed a pruritic bullous eruption while on prednisone.

prednisone

a pruritic bullous eruption

A 14-year-old girl with newly diagnosed SLE

developed


Input: Sodium valproate and carbamazepine, antiepileptic drugs that are associated with a relatively low rate of adverse cutaneous reactions, should be added to the growing list of drugs that produce psoriasiform eruptions.

Sodium valproate and carbamazepine

adverse cutaneous reactions

associated with


Input: Tirapazamine plus cisplatin versus cisplatin in advanced non-small-cell lung cancer: A report of the international CATAPULT I study group.

Tirapazamine plus cisplatin

in


Input: Exfoliative dermatitis secondary to tobramycin sulfate.

Exfoliative dermatitis

tobramycin sulfate.

secondary to


Input: Kaposi's sarcoma in a patient treated with imatinib mesylate for chronic myeloid leukemia.

Kaposi's sarcoma

a patient

imatinib mesylate

treated


Input: A young patient experienced marked sinus tachycardia while smoking marijuana and receiving therapeutic doses of nortriptyline.

young patient

sinus tachycardia

nortriptyline

experienced


Input: Hypogammaglobulinemia associated with gold therapy: evidence for a partial maturation blockade of B cells.

Hypogammaglobulinemia

a partial maturation blockade of B cells

gold therapy

associated


Input: Experience with five patients in whom impaired renal function developed early during amphotericin B therapy is reported.

five patients

impaired renal function

amphotericin B therapy

developed


Input: This report details the pulmonary pathologic findings in four patients with rheumatoid arthritis, who developed new onset of pulmonary signs and symptoms with alveolar infiltrates temporally related to the institution of etanercept therapy.

institution of etanercept therapy

developed new onset of pulmonary signs and symptoms with alveolar infiltrates

four patients with rheumatoid arthritis

related to


Input: CONCLUSION: Hypersensitivity reaction should be considered in patients who develop recurrent eosinophilia and deterioration of pulmonary function following the use of tobramycin by inhalation or by intravenous administration.

recurrent eosinophilia and deterioration of pulmonary function

use of tobramycin by inhalation or by intravenous administration

patients

develop


Input: NCSE, an epileptic disorder in which typical convulsive activity is absent, has previously been reported in only 4 patients receiving ifosfamide.

NCSE

ifosfamide

4 patients

receiving


Input: We describe a case of life-threatening hyponatremia associated with sibutramine use in an obese woman.

hyponatremia

sibutramine

obese woman

life-threatening

associated


Input: Polymyoclonus seizure resulting from accidental injection of tranexamic acid in spinal anesthesia.

Polymyoclonus seizure

accidental injection of tranexamic acid in spinal anesthesia

resulting


Input: Hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) have been associated with myopathy and rhabdomyolysis.

Hydroxymethylglutaryl coenzyme A reductase inhibitors (statins)

myopathy and rhabdomyolysis

associated


Input: Propranolol-induced hypertension in treatment of cocaine intoxication.

Propranolol

hypertension

induced


Input: This is the second report of lactic acidosis in a patient on stavudine and lamivudine.

lactic acidosis

a patient

stavudine and lamivudine

on


Input: We report on a patient with renal artery stenosis who had only 1 kidney and in whom acute renal impairment developed with transient anuria after the administration of captopril.

a patient with renal artery stenosis who had only 1 kidney

acute renal impairment developed with transient anuria

the administration of captopril

after


Input: However, in the mid-to-late 1980s, a series of letters to the editor and case reports announced an association between tamoxifen therapy in women with breast cancer and the development of endometrial carcinoma.

tamoxifen

women with breast cancer

endometrial carcinoma

development


Input: Simvastatin-induced rhabdomyolysis following cyclosporine treatment for uveitis.

cyclosporine treatment

Simvastatin

rhabdomyolysis

induced


Input: Based on our previous demonstration that quinine could be used clinically to reverse P-glycoprotein-mediated resistance, we designed a multicenter, randomized trial aiming to determine whether quinine would improve the survival of adult patients (15-60 years old) with de novo acute myelogenous leukemia (AML).

quinine

reverse P-glycoprotein-mediated resistance

adult patients (15-60 years old)

whether

improve


Input: Vincristine induced cranial polyneuropathy.

Vincristine

cranial polyneuropathy

induced


Input: Here we describe another case of VOD occurring after LT, but in which the causative role was played by azathioprine.

VOD

azathioprine

occurring


Input: A retrospective review of TTP patients with quinine-associated thrombotic microangiopathy (TMA) for whom ADAMTS13 was measured before plasma exchange was performed.

TTP patients

quinine

thrombotic microangiopathy (TMA)

associated


Input: Rituximab-CHOP induced interstitial pneumonitis in patients with disseminated extranodal marginal zone B cell lymphoma.

Rituximab-CHOP

interstitial pneumonitis

patients with disseminated extranodal marginal zone B cell lymphoma

induced


Input: Nitrendipine is an experimental calcium channel blocking agent that also appears to cause the side effect of drug-induced gingival hyperplasia.

Nitrendipine is an experimental calcium channel blocking agent

gingival hyperplasia

cause


Input: The present study describes a patient who had unusual weight fluctuation under corticosteroid and psychotropic treatment such as mianserin and aripiprazole.

unusual weight fluctuation

corticosteroid and psychotropic treatment such as mianserin and aripiprazole

patient

had


Input: Clozapine-induced akathisia in children with schizophrenia.

Clozapine

akathisia

children with schizophrenia

induced