Input: Physicians should be aware that PLP can occur after initiation of paclitaxel.

paclitaxel

PLP

can

occur


Input: Heparin-dependent antibodies and thrombosis without heparin-induced thrombocytopenia.

thrombocytopenia

heparin

induced


Input: Treatment of lithium tremor with metoprolol.

metoprolol

Treatment of


Input: A 54-year-old man, treated with amiodarone, developed thyrotoxicosis.

A 54-year-old man

amiodarone

thyrotoxicosis

developed


Input: Gynaecomastia is a rarely reported adverse drug reaction due to isoniazid therapy.

isoniazid therapy

Gynaecomastia

adverse drug reaction


Input: The authors performed a literature search using PubMed and the search terms "gemcitabine" and "radiation recall" to find prior cases of radiation recall attributed to gemcitabine.

gemcitabine

prior cases

radiation recall

attributed


Input: Carbamazepine-induced Diabetes mellitus.

Diabetes mellitus

Carbamazepine

induced


Input: She displayed symptoms of ST 8 days after the introduction of linezolid.

8 days after the introduction of linezolid

symptoms of ST

She

displayed


Input: Naproxen is a commonly used nonsteroidal anti-inflammatory drug (NSAID) whose side effects include tinnitus and transient hearing loss.

Naproxen

tinnitus and transient hearing loss

include


Input: The allopurinol hypersensitivity syndrome is a rare adverse drug reaction.

hypersensitivity syndrome

allopurinol

adverse


Input: The pulmonary toxicity is probably induced by piritrexim.

pulmonary toxicity

piritrexim

probably

induced


Input: BACKGROUND: Interferon (IFN)-associated retinopathy is typically characterized by retinal hemorrhages and cotton wool spots at the posterior fundus, but visual function is usually maintained.

Interferon (IFN)

retinopathy is typically characterized by retinal hemorrhages and cotton wool spots at the posterior fundus

associated


Input: We describe a patient with a liver abscess due to Entamoeba histolytica, in whom metronidazole therapy (total dose, 21 g over 14 days) was complicated by reversible deafness, tinnitus, and ataxia and who relapsed 5 months later with a splenic abscess.

a patient with a liver abscess due to Entamoeba histolytica

metronidazole therapy (total dose, 21 g over 14 days)

reversible deafness, tinnitus, and ataxia and who relapsed 5 months later with a splenic abscess

complicated


Input: We present a Japanese male patient who underwent a living-donor kidney transplantation having received tacrolimus, mycophenolate mofetil, and prednisolone for immunosuppression.

a Japanese male patient who underwent a living-donor kidney transplantation

immunosuppression

tacrolimus, mycophenolate mofetil, and prednisolone

received


Input: Gold nephropathy due to auranofin obscured by tolmetin pseudoproteinuria.

Gold nephropathy

auranofin

due


Input: We report three cases of amiodarone-induced torsades de pointe.

three cases

amiodarone

torsades de pointe

induced


Input: Torsades de pointes due to drug interaction between disopyramide and clarithromycin.

drug interaction between disopyramide and clarithromycin

Torsades de pointes

due to


Input: We describe a patient who developed HUS after treatment with mitomycin C (total dose 144 mg/m2) due to a carcinoma of the ascending colon.

a patient

HUS

mitomycin C (total dose 144 mg/m2)

developed


Input: In this case, 5-FU increased PHT, which in turn may have increased the PB concentration, suggesting that when fluoropyrimidine antitumor agents are administered to patients receiving PHT in combination with other drugs, some measures should be taken in consideration of secondary effects of antitumor agents on other drugs that may possibly interact with PHT, including frequent monitoring of blood drug concentration.

5-FU increased PHT, which in turn may have increased the PB concentration

secondary effects of antitumor agents on other drugs

patients

suggesting

interact


Input: Severe loss of vision after removal of cataract caused by intravitreal triamcinolone in combination with photodynamic therapy for exudative age-related macular degeneration.

Severe loss of vision

intravitreal triamcinolone

photodynamic

caused


Input: The CATAPULT I study shows that tirapazamine enhances the activity of cisplatin in patients with advanced NSCLC and confirms that hypoxia is an exploitable therapeutic target in human malignancies.

patients with advanced NSCLC

tirapazamine

enhances the activity of cisplatin

enhances


Input: Cardiac arrest associated with sulprostone use during caesarean section.

Cardiac arrest

sulprostone

associated


Input: Linear IgA bullous dermatosis occurring after carbamazepine.

Linear IgA bullous dermatosis

carbamazepine

occurring


Input: Erythropoietin is beneficial in mitomycin-induced hemolytic-uremic syndrome.

Erythropoietin

beneficial

mitomycin

hemolytic-uremic syndrome

induced


Input: Hypothyroidism, occurring in up to 11 percent of patients treated with amiodarone, can also alter drug metabolism and sensitize the central nervous system, thus increasing the potential for toxicity.

Hypothyroidism

11 percent of patients

amiodarone

potential

occurring


Input: We report the first case of herpes esophagitis in a renal transplant patient treated with Cyclosporine A while on chronic steroid therapy.

herpes esophagitis

a renal transplant patient

Cyclosporine A while on chronic steroid therapy

in


Input: Severe hepatocellular dysfunction following cyproterone acetate therapy.

Severe hepatocellular dysfunction

cyproterone acetate

Severe

following


Input: It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called "3-week sulphasalazine syndrome", a rare, but often fatal, immunoallergic reaction to sulphasalazine.

3-week sulphasalazine syndrome

sulphasalazine

fatal

immunoallergic reaction


Input: Two patients with bipolar affective disorder and a history of bronchospastic phenomena experienced tremor during lithium carbonate therapy.

Two patients with bipolar affective disorder and a history of bronchospastic phenomena

tremor

lithium carbonate therapy

experienced


Input: Acute renal failure most likely was secondary to the nephrotoxic effect of captopril on chronically hypoperfused kidneys.

Acute renal failure

captopril

chronically hypoperfused kidneys

most likely

nephrotoxic effect


Input: We report a case of radiotherapy-enhanced aminoglutethimide skin toxicity in a patient with metastatic breast cancer.

radiotherapy-enhanced aminoglutethimide

skin toxicity

a patient with metastatic breast cancer

toxicity


Input: Clinicians should also be aware of the possibility of serotonin syndrome when encountering a patient taking serotonergic drugs who presents with characteristic symptoms of serotonin syndrome.

serotonin syndrome

serotonergic drugs

a patient

possibility

taking


Input: Such a rapid and relentless progression of methyldopa-induced liver injury is undoubtedly rare, but it may be prevented by careful supervision of patients who exhibit liver function abnormalities early in the course of therapy.

methyldopa

liver injury

may

induced


Input: In eight patients, a mean decrease in serum Na+ of 8.25 +/- 3.2 mEq/L was observed after a single 200 mg intravenous dose of lorcainide.

eight patients

mean decrease in serum Na+ of 8.25 +/- 3.2 mEq/L

a single 200 mg intravenous dose of lorcainide

observed


Input: Nitrendipine-induced gingival hyperplasia.

Nitrendipine

gingival hyperplasia

induced


Input: Extensive immunological investigations were performed in a patient with definite seronegative rheumatoid arthritis who developed hypogammaglobulinemia in the course of gold therapy.

a patient with definite seronegative rheumatoid arthritis

hypogammaglobulinemia

gold therapy

developed


Input: When SASP was changed to 5-aminosalicylic acid (5-ASA), his skin eruptions were resolved, however, he developed weakness and atrophy in his right arm as well as progressive worsening of the dysesthesia in his legs and gait disturbance.

he

weakness and atrophy in his right arm as well as progressive worsening of the dysesthesia in his legs and gait disturbance.

SASP was changed to 5-aminosalicylic acid (5-ASA)

developed

SASP was changed to 5-aminosalicylic acid (5-ASA)

resolved


Input: One case of tacrolimus-induced hepatic VOD developing after lung transplantation (LT) has been recently reported.

tacrolimus

after lung transplantation (LT)

hepatic VOD

induced


Input: We describe a case of an NHL patient who received rituximab and developed symptomatic, biopsy-proven multinodular bronchiolitis obliterans with organizing pneumonia (BOOP).

an NHL patient

rituximab

symptomatic, biopsy-proven multinodular bronchiolitis obliterans with organizing pneumonia (BOOP)

developed


Input: We describe a case of TdP caused by a drug interaction in a 76-year-old woman taking long-term disopyramide after she was given clarithromycin concomitantly for chronic bronchitis.

76-year-old woman

long-term disopyramide

clarithromycin

TdP

taking


Input: Thus, clinical recognition of sleep disordered breathing should be taken into account when rheumatoid arthritis patients are to be treated with infliximab.

infliximab

sleep disordered breathing

rheumatoid arthritis patients

with


Input: We present a case of a sustained monomorphic ventricular tachycardia following adenosine infusion.

adenosine infusion

sustained monomorphic ventricular tachycardia

following


Input: Provocation of non-convulsive status epilepticus by tiagabine in three adolescent patients.

three adolescent patients

tiagabine

non-convulsive status epilepticus

Provocation


Input: We recommend that a TMA in association with quinine be consistently referred to as quinine-associated thrombotic microangiopathy (quinine-TMA) to better distinguish this entity from idiopathic TTP.

quinine

quinine-associated thrombotic microangiopathy (quinine-TMA)

associated


Input: The authors describe a case of oral-facial dyskinesia that occurred after discontinuation of amoxapine, and antidepressant which may also have neuroleptic effects.

discontinuation of amoxapine, and antidepressant which may also have neuroleptic effects

oral-facial dyskinesia

occurred


Input: A 34-year-old HIV-infected man who had recently initiated efavirenz-based antiretroviral therapy was diagnosed with disseminated Histoplasma capsulatum infection.

A 34-year-old HIV-infected man

initiated efavirenz-based antiretroviral therapy

initiated


Input: Aminoglutethimide was discontinued until completion of radiotherapy, and the rash resolved.

Aminoglutethimide was discontinued until completion of radiotherapy

the rash resolved

and


Input: We explored ophthalmic and neurologic findings in two children who have been exposed prenatally to VGB.

ophthalmic and neurologic findings

two children

exposed prenatally to VGB

VGB

explored


Input: Two cases are described of chronic schizophrenic patients maintained on depot neuroleptics, who developed severe extrapyramidal symptoms following a period of heavy betel nut consumption.

heavy betel nut consumption

depot neuroleptics

Two cases

severe extrapyramidal symptoms

developed


Input: Five personal observations of an acute amnestic episode in younger individuals after intake of clioquinol are described together with three observations from the medical literature.

younger individuals

intake of clioquinol

acute amnestic episode

after


Input: In a patient with severe renovascular hypertension, nonoliguric acute renal failure developed after she received captopril treatment.

captopril

nonoliguric acute renal failure

a patient with severe renovascular hypertension

after


Input: A 30-year-old pharmacist suffered from acute allergic contact dermatitis due to 4-chloro-7-nitrobenzofurazan (NBD-Cl).

A 30-year-old pharmacist

acute allergic contact dermatitis

4-chloro-7-nitrobenzofurazan (NBD-Cl)

suffered


Input: CONCLUSION: This rare case of PTU-induced ANCA-associated vasculitis manifested with ototoxicity in combination with systemic involvement.

ANCA-associated vasculitis manifested with ototoxicity in combination with systemic involvement

PTU

induced


Input: A 15-year follow-up of phenytoin-induced unilateral gingival hyperplasia: a case report.

phenytoin

unilateral gingival hyperplasia

induced


Input: We describe two patients with rheumatoid factor-positive, polyarticular-onset juvenile rheumatoid arthritis in whom accelerated nodulosis developed during methotrexate therapy.

two patients with rheumatoid factor-positive, polyarticular-onset juvenile rheumatoid arthritis

accelerated nodulosis

methotrexate therapy

developed


Input: The clinical data suggest that anterior lumbosacral radiculopathy is also a type of neurologic complication associated with intrathecal methotrexate treatment.

anterior lumbosacral radiculopathy

intrathecal methotrexate

associated


Input: At admission simvastatin and all antiviral drugs were discontinued because toxicity due to a drug-drug interaction was suspected.

simvastatin and all antiviral drugs

toxicity

suspected

due


Input: A major limitation in the use of amphotericin B is its potential to cause nephrotoxicity.

amphotericin B

nephrotoxicity

potential

cause


Input: We report a case of hyperpigmentation due to bleomycin treatment in a patient with acquired immune deficiency syndrome (AIDS).

hyperpigmentation

bleomycin

a patient with acquired immune deficiency syndrome (AIDS)

due


Input: Azathioprine-induced myelosuppression due to thiopurine methyltransferase deficiency in a patient with autoimmune hepatitis.

Azathioprine

myelosuppression

a patient with autoimmune hepatitis

induced


Input: Captopril-associated "pseudocholangitis'.

Captopril

pseudocholangitis

associated


Input: A case of toxic hepatitis caused by combination therapy with methotrexate and etretinate in the treatment of severe psoriasis is presented in a 47-year-old woman.

toxic hepatitis

combination therapy with methotrexate and etretinate

psoriasis

a 47-year-old woman

caused


Input: Thrombin is highly effective for stopping intractable arterial hemorrhage during stereotactic brain biopsy; however, it is a vasospastic agent and may have been responsible for the cerebral infarctions in one patient.

Thrombin

highly effective

stopping

Thrombin

cerebral infarctions

one patient

responsible


Input: Carboplatin hypersensitivity presenting as coronary vasospasm - a case report.

Carboplatin

coronary vasospasm

presenting


Input: Severe hypoglycemia from Helicobacter pylori triple-drug therapy and insulin detemir drug interaction.

Helicobacter pylori triple-drug therapy and insulin detemir drug interaction

Severe hypoglycemia

Severe

from


Input: The aim of this study was to describe the occurrence of acute coronary syndromes in 3 cases of rituximab infusions.

acute coronary syndromes

rituximab infusions

occurrence


Input: Acute pharmacokinetic and pharmacodynamic interactions between phenytoin and isradipine were probably responsible for the lethargy, dysarthria, ataxia, and weakness our patient developed.

Acute pharmacokinetic and pharmacodynamic interactions between phenytoin and isradipine

the lethargy, dysarthria, ataxia, and weakness

probably

responsible


Input: A patient suffering from a rare enzyme deficiency developed a malignant neuroleptic syndrome after having been treated with one single dose of haloperidol.

A patient suffering from a rare enzyme deficiency

malignant neuroleptic syndrome

one single dose of haloperidol

treated


Input: Captopril is known to be associated with dermatologic, hematologic, and pulmonary adverse effects.

Captopril

dermatologic, hematologic, and pulmonary adverse effects

associated


Input: Here, we present a case of sirolimus-associated interstitial pneumonitis in a cardiac transplant recipient that resolved completely with withdrawal of the drug and treatment with corticosteroids.

a case of sirolimus-associated interstitial pneumonitis in a cardiac transplant recipient

withdrawal of the drug and treatment with corticosteroids

resolved

interstitial pneumonitis

sirolimus

associated


Input: Other upper tract neoplasms after cyclophosphamide are reviewed.

upper tract neoplasms

cyclophosphamide

after


Input: Four patients receiving high-dose tamoxifen for greater than 1 year have demonstrated similar retinal changes.

high-dose tamoxifen for greater than 1 year

retinal changes

Four patients

receiving


Input: Retinal dysfunction and anterior segment deposits in a patient treated with rifabutin.

rifabutin

Retinal dysfunction and anterior segment deposits

patient

treated


Input: Carbamazepine induced right bundle branch block in a Greenlandic patient.

Carbamazepine

right bundle branch block

Greenlandic patient

induced


Input: RESULTS: Both cases presented here describe corneal ulcers that persisted and showed signs of worsening during weeks of frequent topical dosing with moxifloxacin.

weeks of frequent topical dosing with moxifloxacin

corneal ulcers that persisted

Both cases

worsening


Input: We describe a case of poisoning with 3,4-methylenedioxymet-amphetamine Ecstasy that presented with all the features suggestive of a fatal outcome, including a creatinine phosphokinase level markedly higher than any previously reported.

poisoning

creatinine phosphokinase level markedly higher

3,4-methylenedioxymet-amphetamine Ecstasy

a case

presented


Input: Ramipril-induced cutaneous vasculitis is particularly rare and our case was atypical because the patient had tolerated lisinopril before.

Ramipril

cutaneous vasculitis

the patient had tolerated lisinopril before

induced


Input: To date, this is the first reported case of what appears to be isolated thrombocytopenia associated with lansoprazole.

isolated thrombocytopenia

lansoprazole

first

associated


Input: A 7-year-old girl developed diabetes mellitus and exocrine pancreatic insufficiency after 3.5 years of almost continuous treatment with azathioprine and/or prednisone for idiopathic auto-immune haemolytic anaemia.

A 7-year-old girl

diabetes mellitus and exocrine pancreatic insufficiency

3.5 years of almost continuous treatment with azathioprine and/or prednisone

developed


Input: The human immunodeficiency virus protease inhibitor ritonavir is a potent inhibitor of the cytochrome P450 3A4 enzyme, and ritonavir's concomitant administration with the substrates of this enzyme may lead to dangerous drug interactions.

drug interactions

ritonavir's concomitant administration with the substrates of this enzyme

may

lead


Input: There remains a paucity of information pertaining to alternative anticoagulation strategies for use during cardiopulmonary bypass concomitant with heparin-induced thrombocytopenia, especially in children.

heparin

thrombocytopenia

children

paucity of information

induced


Input: Unintended exposure to acyclovir early in pregnancy, which is not uncommon, may cause excessive maternal and physician anxiety.

Unintended exposure to acyclovir

excessive maternal and physician anxiety

may

cause


Input: The ACE inhibitors can cause various skin side effects; however, it rarely causes cutaneous vasculitis.

ACE inhibitors

skin side effects

can

cause


Input: Salicylate intoxication was excluded, and theophylline was finally incriminated.

theophylline

incriminated


Input: We present a case of stroke after PPA ingestion that occurred 4 months after the recall in an 8-year-old boy on chronic peritoneal dialysis.

stroke

PPA

an 8-year-old boy on chronic peritoneal dialysis

after


Input: Cerebral infarcts in a pediatric patient secondary to phenylpropanolamine, a recalled medication.

pediatric patient

Cerebral infarcts

phenylpropanolamine

secondary


Input: To our knowledge, our report is one of the first on shock and angio-oedema from irbesartan.

irbesartan

shock and angio-oedema

from


Input: Clinical course of macular edema in two cases of interferon-associated retinopathy observed by optical coherence tomography.

two cases

macular edema

retinopathy

interferon

associated


Input: This report describes a 13-year-old female with a right frontal high-grade glioma and complex partial seizures who developed localized purpura after 23 months of lamotrigine monotherapy.

23 months of lamotrigine monotherapy

localized purpura

a 13-year-old female with a right frontal high-grade glioma and complex partial seizures

after


Input: Patient 1 presented bilateral ballism 1 week after intravenous heroin injection.

Patient 1

bilateral ballism

intravenous heroin injection

presented


Input: He became hyperkalemic on rechallenge with timolol and normokalemic following its withdrawal.

He

hyperkalemic

timolol

following


Input: Ischaemic colitis in a patient taking meloxicam.

meloxicam

Ischaemic colitis

a patient

taking


Input: Leflunomide-associated infections in rheumatoid arthritis.

infections

Leflunomide

associated


Input: Cutaneous sarcoidosis during interferon alfa and ribavirin treatment of hepatitis C virus infection: two cases.

Cutaneous sarcoidosis

two cases

interferon alfa and ribavirin treatment of hepatitis C virus infection

during


Input: Acute renal failure in a child associated with acyclovir.

Acute renal failure

a child

acyclovir

associated


Input: Bevacizumab is a recently developed monoclonal antibody against vascular endothelial growth factor receptor used to inhibit angiogenesis.

Bevacizumab is a recently developed monoclonal antibody

inhibit


Input: Two patients with rheumatoid arthritis developed evidence of hepatotoxicity while receiving D-penicillamine.

Two patients with rheumatoid arthritis

hepatotoxicity

D-penicillamine

developed


Input: Fatal venous thrombembolism complicating imatinib therapy in a patient with metastatic gastrointestinal stromal tumor.

a patient with metastatic gastrointestinal stromal tumor

imatinib

Fatal venous thrombembolism

Fatal

complicating


Input: However, acute cardiomyopathy and pericarditis secondary to methylphenidate use has been rarely reported.

methylphenidate

acute cardiomyopathy and pericarditis

acute

use


Input: Propoxyphene-induced wide QRS complex dysrhythmia responsive to sodium bicarbonate--a case report.

Propoxyphene

wide QRS complex dysrhythmia

induced


Input: Simvastatin plasma concentration increased 30 times in this patient and statin induced muscle toxicity is related to the concentration of the statin in blood.

muscle toxicity

statin

Simvastatin plasma concentration increased 30 times in this patient

induced


Input: Poorly controlled hypertension in a painter with chronic lead toxicity.

Poorly controlled hypertension

a painter

lead

with


Input: It was concluded that ANCA is closely related to the pathogenesis of crescentic glomerulonephritis and that treatment with PTU appeared to induce ANCA.

PTU

ANCA

appeared to

induce


Input: Gelatinous transformation of bone marrow following chemotherapy for myeloma.

chemotherapy

Gelatinous transformation of bone marrow

following


Input: We discuss a case with significant progressive peripheral neurological deterioration following administration of both fludarabine and cytarabine as part of the FLA (fludarabine and cytarabine) regime.

a case

significant progressive peripheral neurological deterioration

fludarabine and cytarabine

FLA (fludarabine and cytarabine) regime

following


Input: The course of delirium due to lithium intoxication.

delirium

lithium intoxication

due


Input: Preadmission warfarin use was not associated with any secondary intracerebral hemorrhage (OR, 1.2; 95% CI, 0.7 to 2.2), symptomatic intracerebral hemorrhage (OR, 1.1; 95% CI, 0.5 to 2.3), or gastrointestinal hemorrhage (OR, 1.1; 95% CI, 0.2 to 5.6).

Preadmission warfarin

any secondary intracerebral hemorrhage (OR, 1.2; 95% CI, 0.7 to 2.2), symptomatic intracerebral hemorrhage (OR, 1.1; 95% CI, 0.5 to 2.3), or gastrointestinal hemorrhage (OR, 1.1; 95% CI, 0.2 to 5.6)

not

associated


Input: In this case of a possible drug-drug interaction between IFN alfa 11 MU TIW and gemfibrozil 600 mg BID in a patient undergoing treatment for IFN-induced hypertriglyceridemia, the Naranjo Adverse Drug Reactions (ADR) Probability Scale score was 7 (ie, ADR possibly related to treatment).

IFN alfa 11 MU TIW

gemfibrozil 600 mg BID

Naranjo Adverse Drug Reactions

a patient undergoing treatment for IFN-induced hypertriglyceridemia

Probability


Input: Stupor from lamotrigine toxicity.

Stupor

lamotrigine

from


Input: Autopsy findings were consistent with bleomycin and oxygen-induced pulmonary damage.

bleomycin and oxygen

pulmonary damage

induced


Input: We report a case of vitiligo that occurred during the second month of interferon alpha 2a therapy for chronic active hepatitis C.

vitiligo

during the second month of interferon alpha 2a therapy

occurred


Input: Vardenafil is a new oral phosphodiesterase inhibitor used for erectile dysfunction.

Vardenafil is a new oral phosphodiesterase inhibitor

used for


Input: CONCLUSION: A patient with CHF and ESRD developed myoclonic muscle spasms after receiving dobutamine by continuous i.v.

dobutamine by continuous i.v

A patient with CHF and ESRD

myoclonic muscle spasms

after


Input: Nail-changes induced by penicillamine.

Nail-changes

penicillamine

induced


Input: The fourth patient showed RLS symptoms that were initially caused by a 20-mg daily olanzapine dosage and were later mitigated when olanzapine was reduced and ropinirole was administered.

The fourth patient

RLS symptoms

20-mg daily olanzapine dosage

caused


Input: Naproxen-associated sudden sensorineural hearing loss.

Naproxen

sudden sensorineural hearing loss

associated


Input: Retinoic acid may increase the risk of bone marrow transplant nephropathy.

Retinoic acid

bone marrow transplant nephropathy

may

increase


Input: A review of published case reports showed a short time to onset of symptoms following the introduction of linezolid, generally within 1-3 days.

a short time to onset of symptoms

introduction of linezolid, generally within 1-3 days

following


Input: Intrathecal chemotherapy with methotrexate or cytosine arabinoside is the standard approach to prophylaxis and treatment of central nervous system leukemia in children.

children

Intrathecal chemotherapy with methotrexate or cytosine arabinoside

treatment


Input: The following day, the patient developed anxiety, panic attacks, tremors, tachycardia, and hypertension that persisted throughout linezolid treatment.

patient

anxiety, panic attacks, tremors, tachycardia, and hypertension

linezolid

developed


Input: Effect of beta-blockade on symptomatic dexamethasone-induced hypertrophic obstructive cardiomyopathy in premature infants: three case reports and literature review.

dexamethasone

hypertrophic obstructive cardiomyopathy

premature infants

induced

premature infants

beta-blockade

Effect


Input: Although transient increases in ectopy after bretylium therapy have been described, presumably due to catecholamine release, the occurrence of life-threatening ventricular arrhythmia leading to cardiac arrest has not previously been emphasized.

transient increases in ectopy

life-threatening ventricular arrhythmia leading to cardiac arrest

bretylium

presumably

not

after


Input: We report three cases of IFN beta induced hepatitis in MS and discuss the pathology findings and possible mechanisms of drug-induced liver injury.

three cases

IFN beta

hepatitis in MS

induced


Input: RTA is one type of nephrotoxicity induced by FK506, and it is reversible in mild cases when appropriately treated.

RTA

nephrotoxicity

induced


Input: The most common side effects associated with amifostine are nausea, vomiting, hypotension, hypocalcemia and allergic reactions.

amifostine

nausea, vomiting, hypotension, hypocalcemia

allergic reactions.

associated


Input: Nonconvulsive status epilepticus due to ifosfamide.

Nonconvulsive status epilepticus

ifosfamide

due


Input: Clinical experience in infectious patients has shown that oral telithromycin 800mg once daily for 5-10 days is effective for the treatment of community-acquired upper and lower respiratory tract infections.

infectious patients

oral telithromycin 800mg once daily for 5-10 days

treatment


Input: Five patients receiving fluoxetine for the treatment of obsessive compulsive disorder or major depression developed akathisia.

Five patients

fluoxetine

akathisia

developed


Input: This fourth type of cutaneous minocycline hyperpigmentation may be a variant of Type I, but based on clinical, pathological and microanalytical differences, appears to be a new entity.

minocycline

hyperpigmentation

may

be


Input: Phenytoin/isradipine interaction causing severe neurologic toxicity.

Phenytoin/isradipine interaction

neurologic toxicity

severe

causing


Input: We report a case of torsade de pointes following a single oral dose of amiodarone (1400 mg or 30 mg kg-1) administered after short intravenous loading for prevention of paroxysmal atrial flutter.

a single oral dose of amiodarone (1400 mg or 30 mg kg-1)

torsade de pointes

following


Input: Traditionally, children with acute lymphoblastic leukemia receive prednisone, as part of multiagent remission-induction chemotherapy.

prednisone

children with acute lymphoblastic leukemia

receive


Input: Propylthiouracil-induced sensorineural hearing loss associated with antineutrophil cytoplasmic antibodies.

Propylthiouracil

sensorineural hearing loss associated with antineutrophil cytoplasmic antibodies

induced


Input: Acute respiratory depression as a complication of nebulised morphine.

nebulised morphine

Acute respiratory depression

complication


Input: We report on a patient with an embryonal teratocarcinoma of the testicle who had the syndrome of inappropriate secretion of antidiuretic hormone after receiving a high dose of vinblastine.

a high dose of vinblastine

syndrome of inappropriate secretion of antidiuretic hormone

a patient with an embryonal teratocarcinoma of the testicle

had


Input: Methotrexate-induced liver cirrhosis.

liver cirrhosis

Methotrexate

induced


Input: A case of oculogyric crisis induced by metoclopramide is described in this paper.

oculogyric crisis

metoclopramide

induced


Input: Early-onset acute transverse myelitis following hepatitis B vaccination and respiratory infection: case report.

Early-onset acute transverse myelitis

hepatitis B vaccination

case

following


Input: The pro-arrhythmic effects of procainamide may be explained on the basis of both its vagolytic action on the atrioventricular node as well as by prolongation of refractoriness in the accessory pathway.

procainamide

pro-arrhythmic effects

may

of


Input: We present the management of agranulocytosis and neutropenic sepsis secondary to carbimazole with recombinant human granulocyte colony stimulating factor (G-CSF).

carbimazole with recombinant human granulocyte colony stimulating factor (G-CSF)

agranulocytosis and neutropenic sepsis

secondary


Input: Cutaneous mycobacterial infection post intravesical BCG installation.

intravesical BCG installation

Cutaneous mycobacterial infection

post


Input: On day 4, following 3 doses of dalteparin, the patient developed acute respiratory distress attributable to a massive right hemothorax confirmed by computed tomography pulmonary angiography (CTPA) and intercostal drainage of 1500 mL of frank blood.

3 doses of dalteparin

the patient

acute respiratory distress attributable to a massive right hemothorax

following


Input: A 4-month regimen of gatifloxacin with rifampin, isoniazid, and pyrazinamide is being evaluated for the treatment of tuberculosis in a phase 3 randomized controlled trial (OFLOTUB).

gatifloxacin

rifampin

isoniazid

pyrazinamide

treatment


Input: We postulate that the bolus of sulprostone resulted in possible coronary spasm that resulted in cardiac arrest.

sulprostone

coronary spasm that resulted in cardiac arrest

postulate

resulted


Input: A 72-year-old woman with a history of thyrotoxicosis presented with sore throat and fever two weeks after starting carbimazole.

72-year-old woman with a history of thyrotoxicosis

sore throat and fever

two weeks after starting carbimazole

presented


Input: Without other causes for the hyponatremia, she was diagnosed with the syndrome of inappropriate antidiuretic hormone, presumably caused by desmopressin.

desmopressin

she

hyponatremia

syndrome of inappropriate antidiuretic hormone

diagnosed


Input: Fatal peripheral neuropathy following FLA chemotherapy.

Fatal peripheral neuropathy

FLA chemotherapy

following


Input: Rhabdomyolysis caused by a potential sitagliptin-lovastatin interaction.

potential sitagliptin-lovastatin interaction

Rhabdomyolysis

potential

caused


Input: A 78-year-old man with a history of congestive heart failure and coronary artery disease began taking amiodarone to suppress sustained ventricular tachycardia.

A 78-year-old man with a history of congestive heart failure and coronary artery disease

amiodarone

suppress


Input: A patient with severe cholestatic jaundice induced by captopril is presented.

captopril

severe cholestatic jaundice

A patient

induced


Input: Three distinct types of minocycline-induced cutaneous pigmentation have been described.

minocycline

cutaneous pigmentation

induced


Input: The occurrence of symptoms that could be ascribed to an acute coronary syndrome should always be taken seriously during the first rituximab infusion and investigated aggressively.

first rituximab infusion

acute coronary syndrome

should always be taken seriously

during


Input: Antithyroid treatment with propylthiouracil (PTU) resulted in elevated hepatic enzymes and after the 12th week of pregnancy treatment was changed to carbimazole (CBZ).

propylthiouracil (PTU)

elevated hepatic enzymes

12th week of pregnancy

resulted

12th week of pregnancy

carbimazole (CBZ)

changed


Input: Antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis associated with propylthiouracil therapy.

propylthiouracil therapy

Antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis

associated


Input: ADH hypersecretion in relation to plasma osmolality was reversed by mizoribin withdrawal, suggesting that bredinin might adversely induce SIADH.

mizoribin withdrawal

plasma osmolality

reversed

bredinin

adversely induce SIADH

might

induce


Input: Heparin-induced thrombocytopenia is a rare and serious complication of anticoagulation therapy.

anticoagulation therapy

thrombocytopenia

serious

complication


Input: Iatrogenic Cushing syndrome after epidural triamcinolone injections in an HIV type 1-infected patient receiving therapy with ritonavir-lopinavir.

Iatrogenic Cushing syndrome

receiving therapy with ritonavir-lopinavir

epidural triamcinolone injections

an HIV type 1-infected patient

after


Input: Otolaryngologists should be made aware of a newer cause of nasal septal perforations resulting from the more recent antiangiogenic therapy used to treat malignancies.

nasal septal perforations

the more recent antiangiogenic therapy

resulting


Input: Following several of these courses of therapy, respiratory distress occurred 9 to 12 days after the chlorambucil was given.

the chlorambucil

respiratory distress

after


Input: Possible mechanisms for damage to the urothelium by ketamine are suggested.

damage to the urothelium

ketamine

Possible

by


Input: Persistent hypoglycemia in a patient with diabetes taking etanercept for the treatment of psoriasis.

Persistent hypoglycemia

a patient with diabetes

etanercept

taking


Input: Cutaneous necrosis after injection of polyethylene glycol-modified interferon alfa.

Cutaneous necrosis

injection of polyethylene glycol-modified interferon alfa

after


Input: We report an unusual case of simultaneous transitional cell carcinoma of the renal pelvis and distal ureter without transitional cell carcinoma of the bladder occurring after chronic cyclophosphamide therapy for nonHodgkin's lymphoma.

simultaneous transitional cell carcinoma of the renal pelvis and distal ureter without transitional cell carcinoma of the bladder

chronic cyclophosphamide therapy

after


Input: In the present paper, we describe two patients with active UC who developed a severe systemic CMV infection during a treatment with an oral microemulsion form of cyclosporine.

oral microemulsion form of cyclosporine

severe systemic CMV infection

two patients with active UC

severe

treatment


Input: Prior to surgery, the patient received droperidol, an agent known to prolong the QT interval.

droperidol

Prior to surgery

the patient

received


Input: OBJECTIVE: We report a case of cutaneous KS lesions in a patient affected by CML treated with imatinib.

cutaneous KS lesions

imatinib

a patient affected by CML

treated with


Input: The FK 506 dose was constant within 21 days after discontinuing phenytoin in Patient 1 who had 36 days of phenytoin therapy.

phenytoin

Patient 1

The FK 506 dose was constant within 21 days

discontinuing


Input: In patients receiving antithrombin III and concomitant heparin, a significantly increased bleeding incidence was observed (23.8% for antithrombin III group vs 13.5% for placebo group; P<.001).

antithrombin III and concomitant heparin

patients

bleeding incidence

significantly

increased


Input: Bone marrow chromosomes were studied in 2 patients with polycythaemia vera (PV) at the time of diagnosis and several times subsequently during therapy with chlorambucil.

chlorambucil

2 patients with polycythaemia vera (PV)

therapy


Input: Procainamide-induced incessant supraventricular tachycardia in the Wolff-Parkinson-White syndrome.

Procainamide

incessant supraventricular tachycardia

induced


Input: To our knowledge, however, this is the first case report of a possible sitagliptin-lovastatin interaction that may have caused rhabdomyolysis.

sitagliptin-lovastatin interaction

rhabdomyolysis

may

caused


Input: A drug addict with staphylococcal endocarditis treated with methicillin, who developed massive proteinuria and acute nephritic syndrome is described.

A drug addict

methicillin

massive proteinuria and acute nephritic syndrome

developed


Input: Although inhibition of the angiotensin-converting enzyme is considered to be efficient treatment for hypertension associated with chronic renal failure, care should be taken when captopril is administered initially to a patient with decreased renal function, under the conditions of sodium and water depletion.

captopril

a patient with decreased renal function

treatment


Input: Two patients with extrapyramidal side effects after the use of fluphenazine decanoate were evaluated by means of IBZM-SPECT.

extrapyramidal side effects

Two patients

fluphenazine decanoate

after


Input: The clinical course suggests that the interstitial pneumonitis was induced by hydroxyurea.

hydroxyurea

interstitial pneumonitis

induced


Input: Disulfiram-induced hepatitis.

Disulfiram

hepatitis

induced


Input: The majority of radiation recall reactions attributed to gemcitabine are reported to affect internal tissue or organs.

radiation recall reactions

gemcitabine

majority

attributed


Input: The known side effects of sibutramine, ie, hypertension and tachycardia, depend on its adrenergic and serotoninergic effects.

sibutramine

hypertension and tachycardia

of


Input: Because at the end of the first month the patient's platelet counts were normal and the thrombocytopenia developed after the co-medication with conventional drugs, it was suspected that the thrombocytopenia might not be attributed to the use of FHP.

thrombocytopenia

FHP

suspected

not

attributed


Input: Two cases of childhood-onset schizophrenia associated with clozapine-induced akathisia responsive to beta-blocker treatment are described.

clozapine

akathisia responsive

Two cases of childhood-onset schizophrenia

induced

Two cases of childhood-onset schizophrenia

beta-blocker treatment

associated


Input: Syndrome of inappropriate secretion of ADH (SIADH) following cisplatin administration in a pulmonary adenocarcinoma patient with a malignant pleural effusion.

Syndrome of inappropriate secretion of ADH (SIADH)

cisplatin

a pulmonary adenocarcinoma patient with a malignant pleural effusion

following


Input: He had an immediate hypersensitivity reaction during the initiation of the MTX infusion with diffuse urticaria, facial swelling, cough, and chest tightness.

hypersensitivity reaction

with diffuse urticaria, facial swelling, cough, and chest tightness

MTX infusion

during


Input: CONCLUSIONS: We present a case of a patient with CML who developed KS 12 months after starting treatment with imatinib 400 mg/d.

a patient

KS

12 months

imatinib 400 mg/d

developed


Input: Grade 3 hepatotoxicity (AST and ALT > 5 to 20 upper limit normal) or higher has been observed in as many as 1.4% of MS patients on IFN beta.

Grade 3 hepatotoxicity

1.4% of MS patients

IFN beta

observed


Input: The second patient was a girl of 6, already on risperidone for ADHD and borderline intellectual functioning when referred.

a girl of 6

risperidone

on


Input: To report a young man on phenytoin who developed acute neurologic symptoms after isradipine was introduced to his treatment regimen and discuss the possible causes of this drug interaction.

a young man

acute neurologic symptoms

phenytoin

isradipine

possible

developed


Input: Reversible sirolimus-associated pneumonitis after heart transplantation.

sirolimus

pneumonitis

associated


Input: We report a girl with the Rett syndrome who had acute encephalopathy probably induced by calcium hopantenate (HOPA).

a girl

calcium hopantenate (HOPA)

Rett syndrome

acute encephalopathy

probably

induced


Input: Only after three subsequent episodes of severe, symptomatic thrombocytopenia over the next four weeks did he say, upon repeat questioning, that he had continued to take quinine for night leg cramps.

symptomatic thrombocytopenia

continued to take quinine

he

night leg cramps

severe

take


Input: An episode of subacute encephalopathy after the infusion of a moderate dose of methotrexate (1500 mg/m2) (MTX) is reported in a young adult with metastastic gastric cancer.

a young adult with metastastic gastric cancer

a moderate dose of methotrexate (1500 mg/m2) (MTX)

subacute encephalopathy

after


Input: Rhabdomyolysis in a hepatitis C virus infected patient treated with telaprevir and simvastatin.

hepatitis C virus infected patient

telaprevir and simvastatin

Rhabdomyolysis

treated


Input: Four days after intravenous Zoledronic acid, the patient presented to emergency room with complaints of carpopedal spasm and bronchospasm.

Four days after intravenous Zoledronic acid

patient

carpopedal spasm and bronchospasm

complaints


Input: Ulcerating enteritis associated with flucytosine therapy.

Ulcerating enteritis

flucytosine therapy

associated with


Input: OBJECTIVES: To describe clinical and pathologic findings in patients noted to develop lower gastrointestinal symptoms when exposed to rofecoxib.

patients

lower gastrointestinal symptoms

rofecoxib

develop


Input: Our findings suggest that significant progression of marrow reticulin fibrosis during imatinib therapy can be an indicator for a return or progression of CML and, in some patients with CML, imatinib may promote cytogenetic clonal evolution, resulting in a poor response to treatment.

significant progression of marrow reticulin fibrosis

imatinib

can

during


Input: Metabolic acidosis induced by cetrimide-chlorhexidine solution in hydatid cyst surgery.

Metabolic acidosis

cetrimide-chlorhexidine solution

induced


Input: Reversal of gold-induced neutropenia with granulocyte colony-stimulating factor (G-CSF).

gold

granulocyte colony-stimulating factor (G-CSF)

neutropenia

granulocyte colony-stimulating factor

induced


Input: Methyldopa-induced liver injury.

Methyldopa

liver injury

induced


Input: After infliximab treatment, additional sleep studies revealed an increase in the number of apneic events and SaO2 dips suggesting that TNFalpha plays an important role in the pathophysiology of sleep apnea.

infliximab

increase in the number of apneic events and SaO2 dips

increase


Input: One patient developed severe hyponatremia with serum Na+ of 108 mEq/L when hydrochlorothiazide was given to control hypertension.

One patient

severe hyponatremia with serum Na+ of 108 mEq/L

hydrochlorothiazide

severe

developed


Input: Thyroid dysfunction has been reported in patients with malignant disease treated with recombinant alpha interferon.

Thyroid dysfunction

patients with malignant disease

recombinant alpha interferon

reported


Input: The authors also determined that their case of myositis developing in the rectus abdominus muscle of a patient with pancreatic adenocarcinoma was the manifestation of radiation recall, thereby bringing the number of patients who developed radiation recall to gemcitabine and were discussed in the current study to 13.

a patient with pancreatic adenocarcinoma

gemcitabine

myositis developing in the rectus abdominus muscle

radiation recall

developed


Input: Even after a strict warning, he took another quinine tablet that evening, which triggered his fifth episode of severe thrombocytopenia, and confirmed the etiology of quinine-induced thrombocytopenia.

quinine tablet

severe thrombocytopenia

triggered


Input: Case 1 presented after 25 months of myelosuppressive therapy a deletion of chromosome no. 12, del (12) (p11), in 60% of the diploid cells.

25 months of myelosuppressive therapy

a deletion of chromosome no. 12, del (12) (p11), in 60% of the diploid cells

Case 1

after


Input: Diabetes Mellitus was observed in a patient given carbamazepine.

carbamazepine

a patient

Diabetes Mellitus

given


Input: Anxiety is common in patients with schizophrenia and pregabalin has been suggested as an off-label add-on treatment.

patients with schizophrenia

pregabalin has been suggested as an off-label add-on treatment

treatment


Input: Large cerebral infarction during praziquantel therapy in neurocysticercosis.

Large cerebral infarction

praziquantel

during


Input: We report a 13 year-old male who developed life-threatening anaphylaxis early in the course of Increlex therapy.

a 13 year-old male

anaphylaxis

Increlex

developed


Input: Drug induced liver injury secondary to interferon-beta (IFN-beta) in multiple sclerosis.

interferon-beta (IFN-beta)

liver injury

secondary


Input: CONCLUSION: Lipoid pneumonia as a result of mineral oil aspiration still occurs in the pediatric population.

Lipoid pneumonia

mineral oil aspiration

pediatric

result


Input: The results from the present study suggest that tissue plasminogen activator treatment appears to be safe in patients with acute ischemic stroke taking warfarin with an international normalized ratio <1.7 and may reduce the risk of poor functional outcome.

taking warfarin with an international normalized ratio <1.7

tissue plasminogen activator treatment

patients with acute ischemic stroke

may reduce the risk of poor functional outcome

appears


Input: Because of chronic asthma, she had been receiving a leukotriene receptor antagonist (montelukast) for 5 years before the current presentation; 1 week before onset she had had 1 week of treatment with two dietary supplements for weight control; one of these included Garcinia Cambogia, a possible cause of two recent cases of hepatitis in the USA; in addition, both formulas contained a citrus derivative that interferes cytochrome functions.

a leukotriene receptor antagonist (montelukast) for 5 years

she

receiving

Garcinia Cambogia

two recent cases

hepatitis

cause


Input: An episode of leukoencephalopathy is reported in a 13-year-old girl who, after standard radiotherapy for a posterior fossa medulloblastoma, received 8 treatments with a protocol containing a 4-hour infusion of 500 mg/m2 methotrexate and 12 mg intrathecal methotrexate.

leukoencephalopathy

13-year-old girl who

standard radiotherapy for a posterior fossa medulloblastoma, received 8 treatments with a protocol containing a 4-hour infusion of 500 mg/m2 methotrexate and 12 mg intrathecal methotrexate

after


Input: BACKGROUND: Accutane a teratogenic prescription drug licensed to treat severe, recalcitrant nodular acne.

Accutane

treat


Input: OBJECTIVE: To report the safe use of fluorouracil in a patient with breast cancer who had allergic reactions to capecitabine.

a patient with breast cancer who had allergic reactions to capecitabine

fluorouracil

safe


Input: Esophageal candidiasis following omeprazole therapy: a report of two cases.

Esophageal candidiasis

omeprazole

two cases

following


Input: We describe a 10-year-old boy with ulcerative colitis who developed acute pancreatitis while on long-term treatment with 5-aminosalicylic acid.

a 10-year-old boy with ulcerative colitis

acute pancreatitis

long-term treatment with 5-aminosalicylic acid

developed


Input: The mechanism of niacin-induced coagulopathy is theorized to be related to diminished coagulation factors, and limited data suggest that this may be more pronounced with extended-release niacin.

niacin

coagulopathy

limited data suggest

induced


Input: OBJECTIVE: To report 2 cases of nonconvulsive status epilepticus (NCSE) following infusion of ifosfamide.

nonconvulsive status epilepticus (NCSE)

infusion of ifosfamide

following


Input: We conclude that the observed toxicity with jaundice was probably caused by an interaction of this popular Chinese formula and temozolomide.

toxicity with jaundice

temozolomide

caused


Input: Pigmentary disorders are recognized adverse effects of the semi-synthetic tetracycline derivative antibiotic, minocycline.

semi-synthetic tetracycline derivative antibiotic, minocycline

Pigmentary disorders

adverse


Input: Pregabalin is an antiepileptic drug with anti-anxiety properties and is approved for treatment of generalized anxiety disorder.

Pregabalin is an antiepileptic drug with anti-anxiety properties

treatment


Input: We report a case of chronic use of HCQ associated with torsade de pointes.

chronic use of HCQ

torsade de pointes

associated


Input: PURPOSE: The occurrence of myoclonus associated with continuous i.v. infusion of dobutamine in a patient with end-stage renal disease (ESRD) is described.

myoclonus

continuous i.v. infusion of dobutamine

a patient with end-stage renal disease (ESRD)

associated with


Input: The case concerns the sudden death of a 29-year-old male during clozapine therapy started 2 weeks before.

a 29-year-old male

clozapine

sudden death

during


Input: In this paper, we report a case of 3 years-old boy who developed acute onset tetraparesia following a viral respiratory infecction and hepatitis B vaccination.

3 years-old boy

acute onset tetraparesia

hepatitis B vaccination

developed


Input: Treatment of ELP in children is generally supportive, with the symptoms and roentgenographic abnormalities resolving within months after stopping the use of mineral oil.

stopping the use of mineral oil

symptoms and roentgenographic abnormalities resolving

after


Input: PET scintigraphy of etoposide-induced pulmonary toxicity.

etoposide

pulmonary toxicity

induced


Input: We report a patient who experienced LABD shortly after starting carbamazepine therapy.

a patient

starting carbamazepine therapy

experienced LABD shortly

after


Input: Fulminant metoclopramide induced neuroleptic malignant syndrome rapidly responsive to intravenous dantrolene.

Fulminant metoclopramide

neuroleptic malignant syndrome

induced


Input: Can ketamine prescribed for pain cause damage to the urinary tract?

ketamine

damage to the urinary tract

cause


Input: Sixteen hours after the first administration of IFN, IFN was suspended by the symptoms of congestive heart failure (CHF).

IFN

congestive heart failure (CHF)

suspended


Input: We believe this is the first report of myocardial infarction due to coronary spasm, demonstrated by angiography associated with L-thyroxine therapy.

myocardial infarction

coronary spasm

L-thyroxine

believe

associated


Input: A 58-year-old woman with rheumatoid arthritis (RA) developed fever, skin eruptions, leukocytopenia, and thrombocytopenia, 3 weeks after treatment with sulfasalazine.

58-year-old woman with rheumatoid arthritis (RA)

fever, skin eruptions, leukocytopenia, and thrombocytopenia

3 weeks after treatment with sulfasalazine

developed


Input: Gold-induced aplastic anemia.

Gold

aplastic anemia

induced


Input: One patient developed large intramural esophageal hematoma as a complication of heparin therapy.

large intramural esophageal hematoma

a complication of heparin therapy

One patient

developed


Input: Mammary gigantism is a rare complication of D-penicillamine treatment.

Mammary gigantism

D-penicillamine treatment

complication of


Input: Cyclobenzaprine shares anticholinergic effects, tachycardia, and dysrhythmic potential with the tricyclic antidepressants (TCAs).

Cyclobenzaprine

with the tricyclic antidepressants (TCAs)

anticholinergic effects, tachycardia, and dysrhythmic

potential

potential


Input: The autopsy findings and a detailed medical history supported the conclusion that clozapine-induced hypersensitivity myocarditis was the most likely cause of death.

clozapine

hypersensitivity myocarditis

death

death

most likely

induced


Input: PURPOSE: To present a case of respiratory depression following the administration of nebulised morphine.

respiratory depression

nebulised morphine

following


Input: METHODS: A 55-year-old woman became stuporous after overdose with lamotrigine (LTG) and valproic acid (VPA) tablets.

A 55-year-old woman

stuporous

overdose with lamotrigine (LTG) and valproic acid (VPA) tablets

became


Input: Recrudescence of imported falciparum malaria after quinine therapy: potential drug interaction with phenytoin.

Recrudescence of imported falciparum malaria

quinine

phenytoin

potential

after


Input: CONCLUSIONS: Clinicians should be aware of the possible association of thrombocytopenia with lansoprazole and discontinue the drug if thrombocytopenia becomes apparent.

lansoprazole

thrombocytopenia

possible

association


Input: One of the subjects who was using extemporaneous topical minoxidil had hypertension and arteriosclerotic disease and the other died of a myocardial infarction.

One of the subjects

extemporaneous topical minoxidil

hypertension and arteriosclerotic disease

had

extemporaneous topical minoxidil

died of a myocardial infarction

the other

died

died


Input: CONCLUSION: Long-term treatment with rifabutin may have a reversible and previously undescribed side-effect on retinal function.

rifabutin

side-effect on retinal function

may

have


Input: Toxic hepatitis due to combination therapy with methotrexate and etretinate in psoriasis.

Toxic hepatitis

methotrexate and etretinate

due


Input: To report the results of therapeutic drug monitoring of lopinavir/ritonavir and itraconazole concentrations in an HIV-infected male who was treated for histoplasmosis.

an HIV-infected male

lopinavir/ritonavir and itraconazole concentrations

treated


Input: Ulcer became worse after tobramycin and gentamycin treatment for 2 days.

Ulcer became worse

tobramycin and gentamycin

after


Input: Thalidomide has proven activity in refractory multiple myeloma (MM), and although single-agent thalidomide has minimal prothrombogenic activity, its combination with cytotoxic chemotherapy is associated with a significantly increased risk of DVT.

single-agent thalidomide

combination with cytotoxic chemotherapy

significantly increased risk of DVT

risk

associated


Input: These cases indicate that sulpiride can cause tardive dyskinesia and that this drug should be administered with caution.

sulpiride

tardive dyskinesia

cause


Input: Well-differentiated endometrial adenocarcinoma of the secretory type (FIGO Grade 1) with minimal myometrial invasion occurred in a postmenopausal patient on tamoxifen therapy 5 years after mastectomy for breast carcinoma.

Well-differentiated endometrial adenocarcinoma of the secretory type (FIGO Grade 1) with minimal myometrial invasion

a postmenopausal patient

tamoxifen therapy 5 years after mastectomy for breast carcinoma.

occurred


Input: Secondary hematologic neoplasm after intravesical chemotherapy for superficial bladder carcinoma.

Secondary hematologic neoplasm

intravesical chemotherapy

after


Input: Ciprofloxacin-induced renal insufficiency in cystic fibrosis.

Ciprofloxacin

renal insufficiency

induced


Input: While the introduction of carmustine wafers (Gliadel wafers) into the tumor resection cavity has been shown to be a beneficial therapy for malignant glioma, it is recognized that clinically significant cerebral edema is a potential adverse effect.

significant cerebral edema

the introduction of carmustine wafers (Gliadel wafers) into the tumor resection cavity

potential

adverse


Input: Didanosine also has a potential for inducing seizures.

Didanosine

seizures

potential

inducing


Input: Obsessive-compulsive symptoms suddenly emerged 10 days after starting risperidone and resolved within 3 days of discontinuation.

Obsessive-compulsive symptoms

risperidone

emerged


Input: Refractory hypoglycemia from ciprofloxacin and glyburide interaction.

Refractory hypoglycemia

ciprofloxacin and glyburide interaction

from


Input: Anaphylactic reaction to recombinant insulin-like growth factor-I.

Anaphylactic reaction

recombinant insulin-like growth factor-I

to


Input: Subtherapeutic warfarin is not associated with increased hemorrhage rates in ischemic strokes treated with tissue plasminogen activator.

Subtherapeutic warfarin

treated with tissue plasminogen activator

increased hemorrhage rates

not

associated


Input: Pediatric heparin-induced thrombocytopenia: management with Danaparoid (orgaran).

Danaparoid (orgaran)

Pediatric

management

Pediatric

heparin

thrombocytopenia

induced


Input: Teicoplanin-induced agranulocytosis that followed vancomycin-induced agranulocytosis suggests a possible cross-reactivity between the 2 drugs.

Teicoplanin

followed vancomycin

agranulocytosis

possible

induced


Input: A 55-year-old woman developed symptoms suggestive of hepatitis 12 weeks after first receiving methyldopa for hypertension.

A 55-year-old woman

hepatitis

methyldopa

developed


Input: Cyclophosphamide can rarely cause interstitial pneumonitis and fibrosis.

Cyclophosphamide

interstitial pneumonitis and fibrosis

cause


Input: Flucytosine-associated diarrhea has been previously described in 6%-10% of patients receiving the drug.

Flucytosine

diarrhea

6%-10% of patients

associated


Input: IV propranolol was used as the initial treatment for his hyperadrenergic state, resulting in a decrease in heart rate but a paroxsymal increase in blood pressure.

IV propranolol

decrease in heart rate but a paroxsymal increase in blood pressure

his hyperadrenergic state

resulting


Input: We believe that this is the first report of secretory carcinoma of the endometrium associated with tamoxifen use.

tamoxifen

secretory carcinoma of the endometrium

associated


Input: Herpes simplex esophagitis in a renal transplant patient treated with cyclosporine A: a case report.

cyclosporine

Herpes simplex esophagitis

renal transplant patient

treated


Input: This clinical course suggests that the sensorimotor polyneuropathy may have been caused by 5-ASA.

sensorimotor polyneuropathy

may

caused


Input: Spontaneous nasal septal perforation with antiangiogenic bevacizumab therapy.

Spontaneous nasal septal perforation

antiangiogenic bevacizumab therapy

with


Input: There are a few case reports on hair loss associated with tricyclic antidepressants and serotonin selective reuptake inhibitors (SSRIs), but none deal specifically with paroxetine.

hair loss

tricyclic antidepressants and serotonin selective reuptake inhibitors

associated


Input: There have been more than 20 observations of the appearance or aggravation of this granulomatosis with interferon alfa and more recently with the combination of interferon alfa plus ribavirin.

more than 20 observations of the appearance or aggravation of this granulomatosis

interferon alfa and more recently with the combination of interferon alfa plus ribavirin

with


Input: CONCLUSION: A 37-year-old African- American man with G6PD deficiency developed hemolytic anemia, hepatitis, orthostatic hypotension, and aseptic meningitis simultaneously after using trimethoprim-sulfamethoxazole.

hemolytic anemia, hepatitis, orthostatic hypotension, and aseptic meningitis

trimethoprim-sulfamethoxazole

A 37-year-old African- American man with G6PD deficiency

developed


Input: All-trans retinoic acid-induced focal myositis, synovitis, and mononeuritis.

All-trans retinoic acid

focal myositis, synovitis, and mononeuritis

induced


Input: Oxygen potentiation of bleomycin-induced pulmonary toxicity is discussed.

pulmonary toxicity

Oxygen potentiation of bleomycin

discussed

induced


Input: CONCLUSIONS: LTG overdose may result in a severe but reversible encephalopathy, a previously undescribed phenomenon.

reversible encephalopathy

LTG overdose

may

severe

result


Input: In this report, we describe a case of rhabdomyolysis and acute renal failure secondary to the interaction between danazol and simvastatin.

rhabdomyolysis and acute renal failure

interaction between danazol and simvastatin

acute

secondary


Input: Infectious toxicity of dexamethasone during all remission-induction chemotherapy: report of two cases and literature review.

Infectious toxicity

dexamethasone

all remission-induction chemotherapy

two cases

during


Input: A 56-year-old white male had been receiving chronic warfarin therapy for 11 years after mechanical heart valve replacement.

A 56-year-old white male

chronic warfarin therapy for 11 years after mechanical heart valve replacement

receiving


Input: Isoniazid associated, painful, bilateral gynaecomastia.

Isoniazid

painful, bilateral gynaecomastia

associated


Input: Electrocardiographic findings and laboratory data indicated a diagnosis of acute myocardial infarction due to the L-thyroxine therapy.

the L-thyroxine therapy.

acute myocardial infarction

due to


Input: Combining methylephedrine and Chinese herbal drugs might carry a risk of stroke.

Combining methylephedrine and Chinese herbal drugs

risk of stroke

might

carry


Input: Coadministration of 200 mg bid voriconazole with 400 mg (or higher) qd efavirenz is contraindicated due to the clinically significant effect of efavirenz on voriconazole pharmacokinetics.

clinically significant effect

Coadministration of 200 mg bid voriconazole with 400 mg (or higher) qd efavirenz

efavirenz on voriconazole

contraindicated


Input: An interaction between niacin and warfarin likely elevated the INR in this patient because of synergistic coagulopathy and pharmacokinetic effects of niacin.

this patient

elevated the INR

interaction between niacin and warfarin

elevated


Input: We present two cases in which both patients suffered with CLS, which we believe was caused following administration of granulocyte colony-stimulating factor, to our knowledge not described in the intensive care patient previously.

two cases in which both patients suffered with CLS

CLS

granulocyte colony-stimulating factor

believe

administration


Input: Capecitabine was discontinued and the allergic reactions resolved after the woman took diphenhydramine for 1 week.

diphenhydramine for 1 week

Capecitabine was discontinued and the allergic reactions resolved

woman

took


Input: Intravenous fluconazole 400 mg, followed by 100 mg every 24 hours according to impaired renal function, was immediately started; to avoid further nephrotoxicity, immunosuppressant therapy was switched from cyclosporine plus mycophenolate mofetil to oral everolimus 0.75 mg every 12 hours.

Intravenous fluconazole 400 mg, followed by 100 mg every 24 hours

immunosuppressant therapy was switched from cyclosporine plus mycophenolate mofetil to oral everolimus 0.75 mg every 12 hours

avoid


Input: We report 3 patients with severe hepatocellular damage due to CPA therapy, 2 with fatal fulminant hepatitis.

3 patients

severe hepatocellular damage

CPA

due

CPA

fatal fulminant hepatitis

fatal

due


Input: Soon after introduction of insulin therapy, she developed severe anasarca, including marked peripheral oedema, ascites and pleural effusion.

insulin

she

anasarca, including marked peripheral oedema, ascites and pleural effusion

severe

developed


Input: We describe a continuous ambulatory peritoneal dialysis (CAPD) patient that developed vancomycin-induced agranulocytosis during treatment for methicillin-resistant Staphylococcus aureus (MRSA)-associated external cuff infection and pneumonia.

a continuous ambulatory peritoneal dialysis (CAPD) patient

vancomycin

agranulocytosis

induced


Input: In both cases, we believe that serotonin syndrome was produced by a combination of an antidepressant and an atypical antipsychotic.

a combination of an antidepressant and an atypical antipsychotic

serotonin syndrome

In both cases

believe

produced


Input: Cyclosporin side effects included hirsutism, hypertension, increased blood levels of urea and creatinine, and abnormalities in liver function tests.

Cyclosporin

hirsutism, hypertension, increased blood levels of urea and creatinine, and abnormalities in liver function tests.

side effects


Input: She displayed severe hyperactivity, agitation and irritability upon switching to methylphenidate medication.

hyperactivity, agitation and irritability

switching to methylphenidate

severe

displayed


Input: To date, only three cases of seizures associated with amphotericin B have been reported in the literature, but healthcare providers should be aware of the potential for this rare adverse effect.

three cases

seizures

amphotericin B

potential

associated


Input: Heparin-induced thrombocytopenia complicated with massive thrombosis of the inferior vena cava after filter placement.

thrombocytopenia complicated with massive thrombosis of the inferior vena cava after filter placement

Heparin

induced


Input: Pharmacokinetics of methadone in human-immunodeficiency-virus-infected patients receiving nevirapine once daily.

human-immunodeficiency-virus-infected patients

methadone

nevirapine once daily

receiving


Input: Three patients receiving gold salt treatment for rheumatoid arthritis developed severe aplastic anemia.

severe aplastic anemia

Three patients

gold salt

severe

developed


Input: A case of anaphylactoid reaction due solely to the use of Gelofusine in a patient with non-haemorrhagic hypovolaemia is presented, with a discussion on the management and the use of allergy identification jewellery.

anaphylactoid

Gelofusine

patient with non-haemorrhagic hypovolaemia

reaction


Input: Nonoliguric acute renal failure after captopril therapy.

captopril

Nonoliguric acute renal failure

after


Input: We report a patient with type 2 diabetes mellitus who, while treated with the antitumor necrosis factor-alpha blocking agent etanercept for severe plaque psoriasis, experienced persistent hypoglycemia requiring the lowering and eventual elimination of his previous insulin regimen.

a patient with type 2 diabetes mellitus

the antitumor necrosis factor-alpha blocking agent etanercept

previous insulin regimen

persistent hypoglycemia

treated


Input: We report the first case of doxycycline-induced hypoglycemia in a young nondiabetic man.

doxycycline

hypoglycemia

a young nondiabetic man

induced


Input: The time course of events suggested that amphotericin B was the cause of the seizures in this AIDS patient.

amphotericin B

seizures

AIDS patient

cause


Input: Focal glomerulonephritis and interstitial nephritis in methicillin-treated, heroin-related infective endocarditis.

heroin

infective endocarditis

related

methicillin

Focal glomerulonephritis and interstitial nephritis

treated


Input: Allergic contact dermatitis from 4-chloro-7-nitrobenzofurazan.

Allergic contact dermatitis

from


Input: We describe a 5-year-old girl showed recovery of vincristine induced cranial polyneuropathy with pyridoxine and pyridostigmine treatment.

a 5-year-old girl

recovery of vincristine induced cranial polyneuropathy

pyridoxine and pyridostigmine treatment

with


Input: Lipoid pneumonia: a silent complication of mineral oil aspiration.

Lipoid pneumonia

mineral oil aspiration

of


Input: Elevated serum triglycerides with clozapine resolved with risperidone in four patients.

risperidone

four patients

resolved

Elevated serum triglycerides

clozapine

with


Input: Seizures associated with fluoxetine therapy.

Seizures

fluoxetine therapy

associated with


Input: Sustained monomorphic ventricular tachycardia after adenosine infusion.

adenosine infusion.

Sustained monomorphic ventricular tachycardia

after


Input: A 9-year-old boy developed acute renal failure following intravenous acyclovir (30 mg/kg per day) administered for 6 days to treat herpetic encephalitis.

A 9-year-old boy

acute renal failure

intravenous acyclovir

developed


Input: We report a 4-year-old girl who presented with acute bilateral blindness, a focal seizure and hypertension 10 days after commencing oxybutynin to treat enuresis.

oxybutynin

a 4-year-old girl

acute bilateral blindness, a focal seizure and hypertension

after


Input: Severe arrhythmia as a result of the interaction of cetirizine and pilsicainide in a patient with renal insufficiency: first case presentation showing competition for excretion via renal multidrug resistance protein 1 and organic cation transporter 2.

Severe arrhythmia

interaction of cetirizine and pilsicainide

a patient with renal insufficiency

result


Input: Reported are three children who developed progressive paraparesis after intrathecal methotrexate administration followed by complete or partial recovery.

three children

intrathecal methotrexate

paraparesis

progressive

developed


Input: We observed ventricular fibrillation in 2 patients who presented to the emergency department with pre-excited atrial fibrillation and were given 12 mg of adenosine.

2 patients who presented to the emergency department with pre-excited atrial fibrillation

12 mg of adenosine

ventricular fibrillation

given


Input: During administration of chemotherapy, the patient progressively developed a complex association of Beau's lines, transverse melanonychia, Muehrcke's lines, and diffuse hyperpigmentation of the skin.

chemotherapy

patient

a complex association of Beau's lines, transverse melanonychia, Muehrcke's lines, and diffuse hyperpigmentation of the skin

developed


Input: Distinct patterns of chromonychia, Beau's lines, and melanoderma seen with vincristine, adriamycin, dexamethasone therapy for multiple myeloma.

vincristine, adriamycin, dexamethasone

Distinct patterns of chromonychia, Beau's lines, and melanoderma

seen


Input: Theophylline intoxication mimicking diabetic ketoacidosis in a child.

a child

Theophylline

Theophylline intoxication

in


Input: We describe a patient who, after receiving his first dose of pregabalin to relieve neuropathic pain, presented with a negative myoclonus.

a patient

pregabalin

negative myoclonus

presented


Input: CONCLUSIONS: The use of fluorouracil treatment with careful monitoring can be considered in a patient with mild allergic reactions to capecitabine.

a patient with mild allergic reactions to capecitabine

fluorouracil treatment with careful monitoring

can be considered


Input: Symptomatic hypocalcaemia and renal impairment associated with bisphosphonate treatment in patients with multiple myeloma.

Symptomatic hypocalcaemia and renal impairment

bisphosphonate treatment

patients with multiple myeloma

associated


Input: Although this G-CSF-driven leucocytosis was alarming it did not appear to have adversely affected the patient's prognosis.

G-CSF

leucocytosis

not

driven


Input: A case of pyridoxine-dependent seizures is reported.

pyridoxine

seizures

A case

dependent


Input: A case of a 53-year-old man who developed acute pneumonitis after bleomycin and moderate oxygen administration is presented.

acute pneumonitis

A case of a 53-year-old man

bleomycin and moderate oxygen

after


Input: Renal tubular acidosis secondary to FK506 in living donor liver transplantation: a case report.

Renal tubular acidosis

a case

secondary


Input: Retinopathy in hepatitis C patients due to combination therapy with pegylated interferon and ribavirin.

pegylated interferon and ribavirin

Retinopathy

hepatitis C patients

due


Input: After excluding other causes of long QT syndrome, the HCQ was suspected as the cause of her ventricular tachycardia.

HCQ

ventricular tachycardia

her

suspected


Input: Phantom limb pain as a manifestation of paclitaxel neurotoxicity.

Phantom limb pain

paclitaxel

manifestation


Input: A case of allopurinol hypersensitivity, possibly the first in a black African, is reported.

a black African

allopurinol

hypersensitivity

possibly

of


Input: Ramipril was stopped and he required a course of steroids after which the rash improved slowly.

a course of steroids

the rash improved slowly

he

improved


Input: Late development of diabetes mellitus after interferon-alfa and ribavirin therapy for chronic hepatitis C: a case report.

interferon-alfa

ribavirin

diabetes mellitus

after


Input: Second cancers including various types of hematological malignancy have been reported in patients with hairy cell leukemia treated with chemotherapy or interferon alfa.

Second cancers including various types of hematological malignancy

patients with hairy cell leukemia

chemotherapy or interferon alfa

reported


Input: A patient with a large hydatid cyst of the left lobe of the liver developed metabolic acidosis following rather liberal use of cetrimide-chlorhexidine solution as a scolicidal agent.

A patient with a large hydatid cyst of the left lobe of the liver

metabolic acidosis

rather liberal use of cetrimide-chlorhexidine solution as a scolicidal agent

developed


Input: INTERVENTIONS AND RESULTS: Cardiac complications were observed in five pediatric patients who received between 4.6 and 40.8 mg/kg/d of amphotericin B.

five pediatric patients

between 4.6 and 40.8 mg/kg/d of amphotericin B

Cardiac complications

received


Input: In this case report, we have described a patient with Crohn's disease who developed subfulminant hepatitis B after the fourth infusion of infliximab due to an unrecognized HBs-antigen carrier state.

subfulminant hepatitis B

a patient with Crohn's disease

fourth infusion of infliximab

developed


Input: We analyzed the incidence of DVT in 232 MM patients who received a combination of chemotherapy and thalidomide on 2 protocols that differed only by the inclusion of doxorubicin in one.

DVT

chemotherapy

thalidomide

232 MM patients

incidence


Input: Valvular heart disease in a patient taking benfluorex.

Valvular heart disease

a patient

benfluorex

taking


Input: The fifth patient exhibited paraesthesia and agitation caused by olanzapine that was misdiagnosed as psychotic agitation.

olanzapine

The fifth patient

paraesthesia and agitation

caused


Input: Hydrocortisone may decrease the incidence of mortality associated with cardiac arrhythmias in children receiving amphotericin B overdoses.

Hydrocortisone

cardiac arrhythmias in children

may

decrease

cardiac arrhythmias in children

amphotericin B overdoses

incidence of mortality

receiving


Input: A review of the literature found 11 children and 2 adults in whom intranasal desmopressin was associated with hyponatremia, all of whom experienced seizures or altered mental status.

hyponatremia

seizures or altered mental status

11 children and 2 adults

intranasal desmopressin

associated


Input: Hepatotoxicity associated with use of D-penicillamine in rheumatoid arthritis.

Hepatotoxicity

D-penicillamine

associated


Input: Accelerated nodulosis during methotrexate therapy for juvenile rheumatoid arthritis.

Accelerated nodulosis

methotrexate

during


Input: Amiodarone is a Class III antiarrhythmic with an adverse-effect profile involving many different organ systems.

Amiodarone

an adverse-effect profile involving many different organ systems

adverse-effect


Input: Nail and skin alterations associated with the use of chemotherapy have been described in the last decade involving various combinations of two different types of nail changes.

Nail and skin alterations

chemotherapy

associated


Input: This report describes a case of flucytosine-associated ulcerating enteritis in which the small bowel x-ray demonstrated severe luminal narrowing, ulceration, and marked separation of loops of bowel.

flucytosine

ulcerating enteritis in which the small bowel x-ray demonstrated severe luminal narrowing, ulceration, and marked separation of loops of bowel

associated


Input: Chromosome abnormalities after chlorambucil therapy of polycythaemia vera.

Chromosome abnormalities

chlorambucil therapy

after


Input: With the use of optical coherence tomography (OCT), two patients with IFN-associated retinopathy who had developed macular edema and reduced visual acuity during the clinical course of IFN therapy were observed.

retinopathy

macular edema and reduced visual acuity

IFN

associated


Input: Atrial fibrillation after vardenafil therapy.

Atrial fibrillation

vardenafil therapy

after


Input: In phase III clinical trials, the telithromycin 800 mg once-daily dose has been shown to provide close to the maximum antimicrobial activity against S. pneumoniae, Haemophilus influenzae and Staphylococcus aureus in patients with community-acquired pneumonia.

telithromycin 800 mg once-daily dose

patients with community-acquired pneumonia

provide


Input: We suggest that meloxicam might have intestinal toxic effects when taken in high doses, because of reduced COX-2 selectivity.

meloxicam

intestinal toxic effects

might

have


Input: Atrial fibrillation following methylprednisolone pulse therapy.

Atrial fibrillation

methylprednisolone pulse therapy

following


Input: Subglottic stenosis in Wegener's granulomatosis: development during cyclophosphamide treatment with response to carbon dioxide laser therapy.

cyclophosphamide treatment with response to carbon dioxide laser therapy

Subglottic stenosis in Wegener's granulomatosis

during


Input: Pregabalin-induced cortical negative myoclonus in a patient with neuropathic pain.

Pregabalin

cortical negative myoclonus

a patient with neuropathic pain

induced


Input: We conclude that quinine does not improve the survival of adult patients with de novo AML, even though it improves CR rate in a small subgroup of patients defined by rhodamine 123 efflux.

quinine

improves CR rate

a small subgroup of patients defined by rhodamine 123 efflux

improves

quinine

adult patients

not

improve


Input: The mechanism of RTA induced by FK506 has not yet been clearly elucidated.

RTA

induced


Input: The risk of new-onset diabetic ketoacidosis in patients with diabetic risk factors who are taking perospirone hydrochloride or other atypical antipsychotics should be kept in mind.

new-onset diabetic ketoacidosis

patients with diabetic risk factors

perospirone hydrochloride or other atypical antipsychotics

risk


Input: Severe symptomatic hyponatremia during sibutramine therapy: a case report.

Severe symptomatic hyponatremia

sibutramine

Severe

during


Input: Zoledronic acid-induced severe hypocalcaemia in a prostate cancer patient with extensive osteoblastic bone metastases.

Zoledronic acid

severe hypocalcaemia

prostate cancer patient with extensive osteoblastic bone metastases

severe

induced


Input: MM patients treated with thalidomide and doxorubicin have a high risk of developing DVT.

MM patients

thalidomide and doxorubicin

a high risk of developing DVT

risk

have


Input: These two cases highlight the importance of considering lopinavir/ritonavir induced arrhythmias when dealing with HIV-positive individuals.

lopinavir/ritonavir

arrhythmias

HIV-positive individuals

induced


Input: Atrial fibrillation occurring in a patient taking etanercept plus methotrexate for rheumatoid arthritis.

Atrial fibrillation

a patient

etanercept plus methotrexate for rheumatoid arthritis

taking


Input: We describe a 52-year-old male diagnosed with stage III multiple myeloma, who was treated with 5-monthly cycles of VAD (vincristine, adriamycin and dexamathasone).

a 52-year-old male

5-monthly cycles of VAD (vincristine, adriamycin and dexamathasone)

treated


Input: We review the literature on previously reported cases of cutaneous necrosis after injection of standard interferon alfa or pegylated interferon alfa-2b and discuss the different pathophysiologic mechanisms that might be involved.

cutaneous necrosis

standard interferon alfa

pegylated interferon alfa-2b

after


Input: Our cohort included 1739 patients with acute ischemic stroke treated with intravenous tissue plasminogen activator of whom 125 (7.2%) were receiving warfarin before admission and had an international normalized ratio <1.7.

1739 patients

intravenous tissue plasminogen activator

treated

125 (7.2%)

warfarin before admission

receiving


Input: Used injudiciously, naloxone can lead to withdrawal syndrome, return of severe pain, and other adverse effects.

Used injudiciously, naloxone

withdrawal syndrome, return of severe pain, and other adverse effects

lead


Input: When vague symptoms develop during desmopressin therapy, hyponatremia must be considered as part of the differential diagnosis.

vague symptoms

hyponatremia

desmopressin

must be considered

during


Input: Intravesical chemotherapy may be associated with a risk of secondary malignancy.

Intravesical chemotherapy

secondary malignancy

may be

associated


Input: In all the cases described here, it is only with the discontinuation of methylphenidate that the adverse reactions resolved and readministration of methylphenidate in two patients did not produce any adverse effect after a drug-free interval.

discontinuation of methylphenidate

adverse reactions

resolved

adverse effect after a drug-free interval

methylphenidate

two patients

not

produce


Input: Discontinuation of methicillin therapy and appropriate antibiotic treatment of endocarditis led to clinical improvement, emphasizing the need to promptly discontinue potential nephrotoxic agents when abnormalities in renal function appear.

abnormalities in renal function

methicillin

potential

appear


Input: CONCLUSIONS: This study confirmed that in most patients MTX-induced liver cirrhosis is not aggressive.

most patients

MTX

liver cirrhosis is not aggressive

induced


Input: We report the case of severe liver toxicity with jaundice during radiochemotherapy with temozolomide likely due to interaction with a popular Chinese herbal formula after surgery for glioblastoma.

severe liver toxicity with jaundice

temozolomide

a popular Chinese herbal formula

due


Input: He was started on oral lansoprazole 60 mg twice daily and, on hospital day 2, his platelet count decreased to 102 x 10(3)/mm(3); on hospital day 3, the platelet count was 36 x 10(3)/mm(3).

oral lansoprazole 60 mg twice daily

He

platelet count decreased

on


Input: She received an accidental 450-mg bolus injection of morphine intrathecally and developed hypertension, status epilepticus, intracerebral hemorrhage, and respiratory failure.

She

450-mg bolus injection of morphine

hypertension, status epilepticus, intracerebral hemorrhage, and respiratory failure

developed


Input: We describe six patients who developed tardive dyskinesia after treatment with sulpiride for depression or gastrointestinal symptoms.

six patients

tardive dyskinesia

sulpiride

developed


Input: A 38-year-old white female with cystic fibrosis treated with venlafaxine 300 mg/day for one year was prescribed linezolid 600 mg intravenously every 12 hours for treatment of methicillin-resistant Staphylococcus aureus (MRSA) pulmonary infection.

A 38-year-old white female

venlafaxine 300 mg/day for one year

treated

A 38-year-old white female

linezolid 600 mg intravenously every 12 hours

treatment


Input: Hepatotoxicity of hycanthone in patients with metastatic breast cancer.

Hepatotoxicity

hycanthone

patients with metastatic breast cancer

of


Input: The authors report five additional cases of capecitabine-induced multifocal leukoencephalopathy.

capecitabine

multifocal leukoencephalopathy

induced


Input: Chlormadinone acetate withdrawal syndrome under combined androgen blockade for advanced prostate cancer.

Chlormadinone acetate

androgen blockade

under


Input: Restless legs syndrome and periodic limb movements during sleep probably associated with olanzapine.

Restless legs syndrome

periodic limb movements during sleep

olanzapine

associated


Input: Evaluation of the literature provides substantial evidence for the use of hydrocortisone in prevention of cardiac arrhythmias.

hydrocortisone

prevention


Input: We report a case of RTA secondary to FK506 administration in liver transplantation.

FK506 administration in liver transplantation

a case of RTA

RTA

secondary


Input: Myoclonus associated with continuous dobutamine infusion in a patient with end-stage renal disease.

continuous dobutamine infusion

Myoclonus

a patient with end-stage renal disease

associated


Input: Amphotericin B nephrotoxicity in humans decreased by salt repletion.

salt repletion

Amphotericin B nephrotoxicity in humans decreased

humans

decreased


Input: Only a few reports of overt jaundice are associated with streptokinase.

overt jaundice

streptokinase

associated


Input: Possible heart failure exacerbation associated with rosiglitazone: case report and literature review.

heart failure exacerbation

rosiglitazone

exacerbation

associated


Input: We report the first case of polymorphic ventricular tachycardia with normal QT interval associated with the oral use of levofloxacin in the absence of other etiologies known to cause these arrhythmias.

polymorphic ventricular tachycardia with normal QT interval

arrhythmias

oral use of levofloxacin

the first case

associated


Input: Reversible leukopenia was documented in an 81-year-old woman treated with adjunctive ibopamine 100 mg t.i.d. for chronic congestive heart failure.

an 81-year-old woman

adjunctive ibopamine 100 mg t.i.d.

Reversible leukopenia

documented


Input: We conjectured that the side effects of insulin, such as anti-natriuresis and increased vascular permeability, might be pronounced in the presence of the hepatic dysfunction that accompanies insulin insensitivity, hyperinsulinaemia and hypoalbuminaemia.

insulin

anti-natriuresis and increased vascular permeability

side effects


Input: Acute myelogenous leukemia in patients receiving chlorambucil as long-term adjuvant chemotherapy for stage II breast cancer.

Acute myelogenous leukemia

patients

receiving chlorambucil as long-term adjuvant chemotherapy

in


Input: We report a case of generalized cutaneous sclerosis associated with muscle and oesophageal involvement in a patient exposed to herbicides containing bromocil, diuron and aminotriazole.

generalized cutaneous sclerosis associated with muscle and oesophageal involvement

herbicides containing bromocil, diuron and aminotriazole

exposed to


Input: Only 3 cases of imatinib-induced tumor lysis syndrome have been reported.

tumor lysis syndrome

imatinib

induced


Input: A 61-year-old patient who had been treated with lisinopril in the past without any problems was commenced on ramipril for left ventricular dysfunction.

A 61-year-old patient who had been treated with lisinopril in the past without any problems

ramipril

commenced


Input: However, repeated intracameral tPA injections may cause unwanted complications such as vitreous hemorrhage.

repeated intracameral tPA injections

unwanted complications such as vitreous hemorrhage

may

cause


Input: In this article, we present the case of a vitiligo patient who was admitted to our facility with an intense burn after the topical use of 8-methoxypsoralen solution as a suntanning agent.

intense burn

topical use of 8-methoxypsoralen solution as a suntanning agent

a vitiligo patient

after


Input: The frequency and relationship of granulocytopenia caused by sustained-release procainamide in patients with tachyarrhythmias are briefly discussed, and prior reported cases are reviewed.

granulocytopenia

procainamide

patients with tachyarrhythmias

caused


Input: Cicatricial entropion associated with chronic dipivefrin application.

Cicatricial entropion

chronic dipivefrin application

associated


Input: Nine delirious patients suffering from lithium intoxication were examined with the Mini-Mental State Exam (MMS) to describe the clinical course of the disorder.

Nine delirious patients

lithium intoxication

lithium

suffering from


Input: Cryptococcus neoformans fatal sepsis in a chronic lymphocytic leukemia patient treated with alemtuzumab: case report and review of the literature.

Cryptococcus neoformans fatal sepsis

a chronic lymphocytic leukemia patient

alemtuzumab

in


Input: Cholestyramine induced hyperchloremic metabolic acidosis.

Cholestyramine

hyperchloremic metabolic acidosis.

induced


Input: Methadone is recommended as being free of some of the neuropsychological side effects noticed with morphine, which are attributed to active metabolites.

neuropsychological side effects

morphine

free

noticed


Input: This is the first reported case of BOOP associated with single-agent rituximab, and along with two other patients we describe, as well as two prior reports of BOOP in NHL patients receiving rituximab-based combinations, strengthens the possibility of a causal relationship.

BOOP

single-agent rituximab

associated


Input: The treatment for acidosis and hyperkalaemia should be started as soon as RTA is diagnosed, and the dosage of FK506 should also be reduced if possible.

acidosis and hyperkalaemia

RTA

of


Input: A 62-year-old woman treated with pranlukast for 2 months developed interstitial pneumonitis with a high fever.

A 62-year-old woman

treated with pranlukast for 2 months

interstitial pneumonitis with a high fever

developed


Input: Neurotoxicity of valacyclovir in peritoneal dialysis: a pharmacokinetic study.

valacyclovir in peritoneal dialysis

Neurotoxicity

Neurotoxicity


Input: He had been taking trimethoprim-sulfamethoxazole for approximately eight days when he revisited his family physician, complaining of headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs, where a maculopapular rash was noted.

headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs

maculopapular rash

trimethoprim-sulfamethoxazole for approximately eight days

He

taking


Input: We present an AIDS patient with severe and prolonged lactic acidosis on stavudine and lamivudine.

stavudine and lamivudine

severe and prolonged lactic acidosis

an AIDS patient

severe and prolonged

present


Input: Sudden cardiac death due to hypersensitivity myocarditis during clozapine treatment.

clozapine

Sudden cardiac death due to hypersensitivity myocarditis

during


Input: It also highlights a current major etiologic question, that is, whether and to what degree lead exposure contributes to the development of hypertension, and raises the issue of whether lead-induced hypertension constitutes a subset of hypertension that is especially amenable to therapy with dietary calcium.

hypertension

lead exposure

whether

contributes


Input: We report an allogeneic bone marrow transplant recipient who developed CMV infection refractory to sequential therapy with ganciclovir, foscarnet, and cidofovir.

sequential therapy with ganciclovir, foscarnet, and cidofovir

allogeneic bone marrow transplant recipient

refractory

refractory


Input: Acute interstitial pneumonia induced by ONO-1078 (pranlukast), a leukotriene receptor antagonist.

Acute interstitial pneumonia

ONO-1078 (pranlukast)

induced


Input: CONCLUSION: Significant ocular complications such as an irreversible decrease of visual acuity may develop in patients treated with pegylated interferon.

pegylated interferon

patients

irreversible decrease of visual acuity

may develop

treated


Input: CONCLUSIONS: This case report showed that the clinical appearance of Hashimoto's disease after IFN-alpha therapy for chronic C hepatitis in our patient was associated with a specific genetic predisposition (DR5) for this pathology.

clinical appearance of Hashimoto's disease

IFN-alpha

our patient

after


Input: We present here a female patient who developed acute bilateral parotitis within minutes of i.v. enalaprilat injection and recovered within 24 hours of stopping the drug and with symptomatic treatment.

a female patient

acute bilateral parotitis

i.v. enalaprilat injection

developed


Input: We describe 2 patients with prior amputation who experienced phantom limb pain (PLP) after receiving paclitaxel therapy.

paclitaxel therapy

phantom limb pain (PLP)

2 patients with prior amputation

after


Input: There is evidence that the angiotensin II receptor antagonist, losartan, increases urate excretion by reducing reabsorption of urate in the renal proximal tubule.

increases urate excretion

reducing reabsorption of urate in the renal proximal tubule.

angiotensin II receptor antagonist, losartan

increases


Input: Although no coagulation study was done and the Meckel's diverticulum is normally associated with bleeding, the particular intensity of the following hemorrhage may have been favored by metformin.

metformin

hemorrhage

may

favored


Input: We describe 2 patients with severe erosive rheumatoid arthritis and rheumatoid vasculitis, respectively, in whom infliximab therapy was associated with peripheral neuropathy due to necrotizing vasculitis in one patient and to progression of preexisting mononeuritis multiplex in the other.

infliximab therapy

peripheral neuropathy

one patient

associated

infliximab therapy

peripheral neuropathy

preexisting mononeuritis multiplex in the other

associated


Input: Upper tract urothelial malignancy after cyclophosphamide therapy: a case report and literature review.

Upper tract urothelial malignancy

cyclophosphamide therapy

after


Input: BACKGROUND: Methotrexate (MTX) may induce liver damage, which in some psoriatics will lead to fibrosis or cirrhosis.

Methotrexate (MTX)

liver damage, which in some psoriatics will lead to fibrosis or cirrhosis

may

induce


Input: The infection proceeded even after treatment with fluconazole.

infection proceeded

fluconazole

after


Input: We report the case of intoxication of a 41-year-old female patient suffering from major depression with mirtazapine complicated by severe hypothermia.

mirtazapine

intoxication

hypothermia

a 41-year-old female patient

severe

with


Input: The bilateral ptosis markedly improved after 7 days of pyridoxine and pyridostigmine treatment and completely resolved after two weeks.

pyridoxine and pyridostigmine treatment

improved


Input: PURPOSE: The case of a patient who developed aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension simultaneously during treatment with trimethoprim-sulfamethoxazole is described.

trimethoprim-sulfamethoxazole

aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension

a patient

developed


Input: Seizures and extrapyramidal symptoms in a patient with Tourette's syndrome, Asperger's syndrome, and multiple sclerosis treated with interferon beta-1a and clomipramine.

Seizures and extrapyramidal symptoms

a patient with Tourette's syndrome, Asperger's syndrome, and multiple sclerosis

interferon beta-1a and clomipramine

treated


Input: Psychotic disorder associated with isoniazid.

isoniazid

Psychotic disorder

associated


Input: The azathioprine dose was low (1 mg/kg) and pancytopenia occurred after 56 days therapy.

56 days therapy

The azathioprine dose was low (1 mg/kg)

pancytopenia

occurred


Input: Findings on discontinuation and rechallenge supported the assumption that the hair loss was a side effect of the paroxetine.

paroxetine.

hair loss

side effect


Input: The successful development and implementation of this protocol will have impact on patients who have anaphylactic reactions to MTX but require this medication for specific diseases.

anaphylactic reactions

MTX

patients

have


Input: Clomiphene is a first line treatment for anovulation, a common cause of infertility.

Clomiphene

treatment


Input: A new case of Creutzfeldt-Jakob disease associated with human growth hormone therapy in New Zealand.

Creutzfeldt-Jakob disease

human growth hormone

A new case

associated


Input: This case study is the second report of localized purpura after prolonged lamotrigine treatment suggesting this may be an atypical lamotrigine-induced drug reaction.

lamotrigine

localized purpura

drug reaction

induced


Input: Extrapyramidal symptoms are well-documented complications of therapy with haloperidol, even when small doses are used.

Extrapyramidal symptoms

haloperidol

small doses

complications


Input: Although cetirizine has less potential for causing arrhythmias than other histamine 1 blockers, such an interaction should be considered, especially in patients with renal insufficiency who are receiving pilsicainide.

patients with renal insufficiency

arrhythmias

cetirizine

potential

less

causing


Input: Bronchiolitis obliterans with organizing pneumonia after rituximab therapy for non-Hodgkin's lymphoma.

rituximab therapy

Bronchiolitis obliterans with organizing pneumonia

after


Input: The case demonstrates that hypersensitivity reaction to pranlukast and resultant ATIN is possible, and that periodic urine testing in patients receiving pranlukast should be considered.

hypersensitivity reaction

pranlukast

to


Input: Successful desensitization to high-dose methotrexate after systemic anaphylaxis.

high-dose methotrexate

systemic anaphylaxis.

after

high-dose methotrexate

Successful desensitization

to


Input: The patient's clinical presentation, histologic features on liver biopsy and favorable course after stopping the drug suggest that barbiturates can be added to the list of agents which can cause submassive hepatic necrosis.

barbiturates

submassive hepatic necrosis

cause


Input: Although there have been numerous reports of effusions, none have provided complete pleural fluid analysis; therefore, we report 2 patients with dasatinib-induced pleural effusion with complete pleural fluid analysis.

dasatinib

pleural effusion

2 patients

induced