Input: Patients with previously untreated NSCLC were randomized to receive either tirapazamine (390 mg/m(2) infused over 2 hours) followed 1 hour later by cisplatin (75 mg/m(2) over 1 hour) or 75 mg/m(2) of cisplatin alone, every 3 weeks for a maximum of eight cycles.

Patients with previously untreated NSCLC

either tirapazamine (390 mg/m(2) infused over 2 hours) followed 1 hour later by cisplatin (75 mg/m(2) over 1 hour) or 75 mg/m(2) of cisplatin alone, every 3 weeks for a maximum of eight cycles

receive


Input: Drug interactions between macrolide antibiotics such as erythomycin and pharmacologic agents that prolong the QT interval have been known to cause TdP. However, clarithromycin is thought to be less frequently associated with drug induced TdP, because it inactivates hepatic cytochrome P-450 to a lesser extent than erythromycin.

TdP

Drug interactions between macrolide antibiotics such as erythomycin and pharmacologic agents that prolong the QT interval

less frequently associated

cause


Input: In a randomised, investigator-blinded, multicentre phase III efficacy trial, 899 infants and children with acute uncomplicated Plasmodium falciparum malaria received six doses of AL according to body weight over 3 days either as crushed tablets (Coartem) or as dispersible tablets.

899 infants and children with acute uncomplicated Plasmodium falciparum malaria

six doses of AL according to body weight over 3 days either as crushed tablets (Coartem) or as dispersible tablets

received


Input: A patient presented with dilated cardiomyopathy after many years of overusing an adrenaline inhaler.

A patient

many years of overusing an adrenaline inhaler

dilated cardiomyopathy

after


Input: Occurrence of withdrawal dyskinesia indicates that the neuroleptic effects of amoxapine may be clinically significant.

amoxapine

withdrawal dyskinesia

may

Occurrence


Input: Hair loss associated with paroxetine treatment: a case report.

paroxetine

Hair loss

a case

associated


Input: RESULTS: In a 22-year-old Thai woman with Graves' disease, tinnitus, hearing impairment in the left ear (with progression to the right ear), and vertigo developed after 3 years of therapy with PTU.

a 22-year-old Thai woman with Graves' disease

tinnitus, hearing impairment in the left ear (with progression to the right ear), and vertigo

after 3 years of therapy with PTU

developed


Input: Additive pulmonary toxicity with melphalan and busulfan therapy.

Additive pulmonary toxicity

melphalan and busulfan therapy

with


Input: We report the case of a 20-year-old woman originally from Cameroon who was infected by the L. loa parasite and developed severe hepatitis, identified 1 month after a single dose of ivermectin.

severe hepatitis

20-year-old woman originally from Cameroon who was infected by the L. loa parasite

1 month after a single dose of ivermectin

developed


Input: To the best of our knowledge, this is the first case of lithium-associated CDI and NDI presenting concurrently.

lithium

CDI and NDI

associated


Input: In this healthy population, the relative risk of developing endometrial carcinoma in the tamoxifen arm was 2.54, although when stratified by age, in women over 50, the risk grew to 4.01.

endometrial carcinoma

healthy population

tamoxifen

developing


Input: Paradoxical ventricular tachycardia and fibrillation after intravenous bretylium therapy.

intravenous bretylium

Paradoxical ventricular tachycardia and fibrillation

after


Input: OBJECTIVE: To describe a case of thrombocytopenia associated with the administration of lansoprazole.

thrombocytopenia

lansoprazole

a case

associated


Input: A patient developed optic neuropathy while being treated with isoniazid and ethambutol.

A patient

optic neuropathy

isoniazid and ethambutol

developed


Input: This case describes a 52-year-old white woman who developed a spontaneous nasal septal perforation after given the antiangiogenic drug, bevacizumab, for metastatic ovarian cancer treatment.

a 52-year-old white woman

a spontaneous nasal septal perforation

antiangiogenic drug, bevacizumab

developed


Input: Two cases are reported of patients who developed a hematologic malignancy several years after intravesical chemotherapy of superficial bladder cancer with etoglucid, doxorubicin, and mitomycin C.

hematologic malignancy

etoglucid, doxorubicin, and mitomycin C

several years after intravesical chemotherapy of superficial bladder cancer with etoglucid, doxorubicin, and mitomycin C

Two cases are reported of patients

developed


Input: Eleven patients developed infection requiring hospitalization while taking leflunomide including: lower respiratory tract infections (3), cellulitis (2), disseminated herpes zoster (2), probable TB liver (1), abdominal sepsis (1), mycotic aneurysm (1) and gastroenteritis (1).

Eleven patients

leflunomide

infection

lower respiratory tract infections (3), cellulitis (2), disseminated herpes zoster (2), probable TB liver (1), abdominal sepsis (1), mycotic aneurysm (1) and gastroenteritis (1)

developed


Input: Symptoms and endoscopic lesions quickly regressed within 1 week of meloxicam withdrawal.

within 1 week of meloxicam withdrawal

regressed


Input: Potential drug interaction between simvastatin and danazol causing rhabdomyolysis.

rhabdomyolysis

drug interaction between simvastatin and danazol

Potential

causing


Input: Multiple myeloma complicated by congestive heart failure following first administration of recombinant alpha-interferon.

Multiple myeloma complicated by congestive heart failure

first administration of recombinant alpha-interferon

following


Input: Carboplatin hypersensitivity induced by low-dose paclitaxel/carboplatin in multiple platinum-treated patients with recurrent ovarian cancer.

Carboplatin hypersensitivity

low-dose paclitaxel/carboplatin

multiple platinum-treated patients with recurrent ovarian cancer

induced


Input: Two cases are reported of patients who developed a hematologic malignancy several years after intravesical chemotherapy of superficial bladder cancer with etoglucid, doxorubicin, and mitomycin C.

patients

a hematologic malignancy

several years after intravesical chemotherapy

with etoglucid, doxorubicin, and mitomycin C

developed


Input: CASE SUMMARY: A 46-year-old African-American man experienced recurrent grand mal seizures during intravenous infusion of amphotericin B, then petit mal seizures as the infusion was stopped and the drug concentrations decreased with time.

recurrent grand mal seizures

intravenous infusion of amphotericin B

A 46-year-old African-American man

grand

experienced


Input: Moreover, these findings suggest that the incidence of BOOP following rituximab therapy may be higher than has been previously appreciated.

rituximab therapy

BOOP

following


Input: Two cases of hypothyroidism in patients with chronic hepatitis C treated with recombinant alpha interferon are reported.

hypothyroidism

recombinant alpha interferon

Two cases

treated


Input: OBJECTIVE: To report the case of a young woman with Graves' disease in whom ototoxicity developed because of propylthiouracil (PTU)-induced antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis.

young woman with Graves' disease

propylthiouracil (PTU)

ototoxicity developed

induced


Input: An obese patient, not diabetic, treated with metformin for some weeks, was referred to us with severe inferior digestive hemorrhage, diagnosed with Meckel's diverticulum.

An obese patient, not diabetic

metformin for some weeks

severe inferior digestive hemorrhage

Meckel's diverticulum

severe

diagnosed


Input: Although a lot of amiodarone-induced torsades de pointe have been published, a review of all these cases and the underlying risk-factors has never been made.

amiodarone

torsades de pointe

induced


Input: However, one patient exhibited severe hypersensitivity reactions including cardiac arrest and apnea, and another four patients developed eruptions, hypotension, and tachycardia soon after administration of CBDCA.

one patient

severe hypersensitivity reactions including cardiac arrest and apnea

CBDCA

administration

CBDCA

four patients

eruptions, hypotension, and tachycardia

administration


Input: This report is about three cases of children who developed severe adverse reactions during switching from risperidone to methylphenidate.

three cases of children

adverse reactions

during switching from risperidone to methylphenidate

severe

developed


Input: This patient, who had a history of osteoarthritis, had severe hepatitis 5 weeks after being started on diclofenac for increasing pain in the joints.

This patient, who had a history of osteoarthritis

5 weeks after being started on diclofenac

hepatitis

severe

had


Input: She received chemotherapy according to the previously described modified St. Jude total therapy studies XIII.

chemotherapy

She

received


Input: A 17-year-old female patient who had been taking oral minocycline (50 mg twice daily) for 3 weeks for acne developed an eruption that progressed to an exfoliative dermatitis.

A 17-year-old female patient

oral minocycline (50 mg twice daily) for 3 weeks

eruption

an exfoliative dermatitis

developed


Input: Risperidone-induced obsessive-compulsive symptoms in two children.

Risperidone

obsessive-compulsive symptoms

two children

induced


Input: CONCLUSIONS: Cicatrization in the substantia propria of the conjunctiva by excessive lymphocytic infiltration after topically administered antiglaucoma drugs including dipivefrin is a possible mechanism of action for entropion.

antiglaucoma drugs including dipivefrin

entropion

possible

mechanism of action


Input: A patient with the Wolff-Parkinson-White syndrome presented with incessant orthodromic atrioventricular tachycardia following initiation of procainamide therapy.

A patient with the Wolff-Parkinson-White syndrome

incessant orthodromic atrioventricular tachycardia

initiation of procainamide therapy

following


Input: Hypersensitivity to carboplatin is a rare but real complication of therapy and should be considered in patients presenting with hyperacute changes on ECG whilst receiving carboplatin therapy.

Hypersensitivity to carboplatin

patients presenting with hyperacute changes on ECG

carboplatin therapy

complication


Input: A well-recognized complication of ethambutol use is optic neuropathy, but the potential ocular toxicity of isoniazid is often overlooked.

ethambutol

optic neuropathy

complication

ocular toxicity

isoniazid

potential

toxicity


Input: PURPOSE: To report that acute lamotrigine poisoning may result in severe encephalopathy.

acute lamotrigine poisoning

severe encephalopathy

may

result


Input: Reversal of ergotamine-induced arteriospasm by mechanical intra-arterial dilatation.

ergotamine

arteriospasm

induced


Input: There have been several case reports of serotonin syndrome from similar combinations of antidepressant and atypical antipsychotic treatment.

serotonin syndrome

combinations of antidepressant and atypical antipsychotic treatment

from


Input: We report the first case of a human immunodeficiency virus type 1 (HIV-1)-infected individual receiving combination antiretroviral therapy, which included ritonavir, who developed Cushing syndrome with profound complications after epidural triamcinolone injections.

Cushing syndrome

combination antiretroviral therapy, which included ritonavir

epidural triamcinolone injections

a human immunodeficiency virus type 1 (HIV-1)-infected individual

Cushing

developed


Input: Disulfiram-like reactions with newer cephalosporins: cefmenoxime.

Disulfiram-like reactions

cefmenoxime

with


Input: We recommend routine follow up by ECG of patients over the age of 50 treated with carbamazepine.

routine follow up by ECG

patients over the age of 50

of


Input: A 10-year-old girl with Lennox-Gastaut syndrome who received intravenous lorazepam for atypical absence status seizures is reported.

intravenous lorazepam

A 10-year-old girl with Lennox-Gastaut syndrome

for


Input: Ritonavir can inhibit the metabolism of fentanyl significantly, so caution should be exercised if fentanyl is given to patients receiving ritonavir medication.

fentanyl

patients receiving ritonavir medication

metabolism of fentanyl significantly

caution


Input: This case emphasizes the importance of the evaluation of lithium-associated polyuria with a direct measurement of plasma vasopressin, interpreted with simultaneous plasma and urine osmolality to secure the correct diagnosis and ensure appropriate therapeutic management.

lithium

polyuria

This case

associated


Input: A patient with chronic myelomonocytic leukemia developed drug-induced pulmonary toxicity after using low dose oral etoposide.

A patient with chronic myelomonocytic leukemia

pulmonary toxicity

using low dose oral etoposide

developed


Input: Alopecia and hair loss are rare side effects of psychotropic drugs.

psychotropic drugs

Alopecia and hair loss

side effects


Input: Occult quinine-induced thrombocytopenia.

quinine

thrombocytopenia

induced


Input: We report the case of a 17-year-old male who developed chest pain, elevated cardiac biomarkers, and acute left ventricular dysfunction following a single dose of methylphenidate.

a 17-year-old male

a single dose of methylphenidate

chest pain, elevated cardiac biomarkers, and acute left ventricular dysfunction

following


Input: In patients with swallowing dysfunction and pneumonia, a history of mineral oil use should be obtained and a diagnosis of ELP should be considered in the differential diagnoses if mineral oil use has occurred.

ELP

a history of mineral oil use

In patients with swallowing dysfunction and pneumonia

considered


Input: Agranulocytosis induced by vancomycin in an ESRD patient on CAPD.

Agranulocytosis

vancomycin

ESRD patient on CAPD

induced


Input: First case of ivermectin-induced severe hepatitis.

ivermectin

severe hepatitis.

induced


Input: The authors suggest that fluoxetine-induced akathisia may be caused by serotonergically mediated inhibition of dopaminergic neurotransmission and that the pathophysiology of fluoxetine-induced akathisia and tricyclic antidepressant-induced "jitteriness" may be identical.

fluoxetine

akathisia may be caused by serotonergically mediated inhibition of dopaminergic neurotransmission

induced


Input: The use of telithromycin in patients receiving multiple doses of oxycodone for pain relief may increase the risk of opioid adverse effects.

patients receiving multiple doses of oxycodone for pain relief

telithromycin

opioid adverse effects

increase the risk


Input: A case of metoclopramide-induced oculogyric crisis in a 16-year-old girl with cystic fibrosis.

a 16-year-old girl with cystic fibrosis

oculogyric crisis

metoclopramide

induced


Input: Supported by a subtherapeutic quinine level, we hypothesise that a drug interaction with phenytoin may compromise the efficacy of quinine in the treatment of malaria.

phenytoin

quinine

efficacy of quinine

may

compromise


Input: Sporadic rippling muscle disease unmasked by simvastatin.

simvastatin

Sporadic rippling muscle disease

unmasked


Input: An objective causality assessment by use of the Naranjo probability scale revealed that NCSE due to ifosfamide was probable.

NCSE

ifosfamide

probable

due


Input: Cis-retinoic acid (RA) may further increase the risk of developing BMTN.

Cis-retinoic acid (RA)

BMTN

may

developing


Input: He was later skin tested to confirm allergy to MTX.

He

allergy

MTX

to


Input: Indolent aspergillus arthritis complicating fludarabine-based non-myeloablative stem cell transplantation.

Indolent aspergillus arthritis

fludarabine

complicating


Input: A case of acute cardiomyopathy and pericarditis associated with methylphenidate.

acute cardiomyopathy and pericarditis

methylphenidate

associated


Input: STUDY DESIGN: Case reports are presented of three premature infants (mean gestational age 27 weeks) cared for in the intensive care nursery in whom clinically significant septal hypertrophy and left ventricular outflow tract obstruction developed during dexamethasone treatment for bronchopulmonary dysplasia.

three premature infants (mean gestational age 27 weeks) cared for in the intensive care nursery

clinically significant septal hypertrophy and left ventricular outflow tract obstruction

during dexamethasone treatment for bronchopulmonary dysplasia

developed


Input: A case of the Rett syndrome with acute encephalopathy induced during calcium hopantenate treatment.

A case of the Rett syndrome

acute encephalopathy

calcium hopantenate treatment

induced


Input: Transient serotonin syndrome caused by concurrent use of tramadol and selective serotonin reuptake inhibitor.

Transient serotonin syndrome

concurrent use of tramadol and selective serotonin reuptake inhibitor

caused


Input: Adverse events associated with IFN alfa-2b use are primarily constitutional symptoms.

primarily constitutional symptoms

IFN alfa-2b

associated


Input: Sustained-release procainamide-induced reversible granulocytopenia after myocardial infarction.

Sustained-release procainamide

reversible granulocytopenia

induced


Input: We describe a patient with M4 AML treated with standard chemotherapy followed by G-CSF who developed marked monocytosis on day 8 of G-CSF therapy.

standard chemotherapy followed by G-CSF

marked monocytosis

a patient with M4 AML

developed


Input: Esophageal candidiasis was diagnosed at endoscopy in two patients receiving omeprazole therapy.

two patients

omeprazole therapy

Esophageal candidiasis

receiving


Input: Bisphosphonate induced osteochemonecrosis of the jaw mimicking a tumour.

Bisphosphonate

osteochemonecrosis of the jaw

induced


Input: OBJECTIVES: To describe the clinicopathologic features of 3 patients with CML who rapidly progressed from chronic phase to blast crisis while taking imatinib and to perform a review of the literature.

3 patients with CML

from chronic phase to blast crisis

imatinib

progressed


Input: Although they had only a few nodules at diagnosis, the nodules increased in number and size 3 to 4 months after the start of methotrexate therapy in both patients.

a few nodules at diagnosis

the nodules increased in number and size

methotrexate therapy

after


Input: CONCLUSIONS: Among the many presentations of ifosfamide neurotoxicity, clinicians should consider NCSE as a possible explanation for changes in consciousness in a patient receiving this agent.

a patient

neurotoxicity

NCSE

changes in consciousness

ifosfamide

possible

receiving


Input: It is concluded that SIADH is an important side effect of lorcainide therapy.

lorcainide therapy

SIADH

side effect


Input: Hepatoxicity is a rare complication of SRL therapy and may be connected with some diagnostic and/or therapeutic problems.

Hepatoxicity

SRL therapy

may be

is


Input: A previous study of patients with "quinine-associated TTP/HUS" found that ADAMTS13 activities were not abnormal in 12/12 patients.

12/12 patients

quinine

ADAMTS13 activities were not abnormal

TTP/HUS

associated


Input: A teenage girl with crescentic glomerulonephritis had antineutrophil cytoplasmic antibody (ANCA) detected after she had received propylthiouracil (PTU) for hyperthyroidism without cutaneous vasculitis.

A teenage girl with crescentic glomerulonephritis

antineutrophil cytoplasmic antibody (ANCA)

propylthiouracil (PTU)

had


Input: Digestive hemorrhage caused by a Meckel's diverticulum in a metformin-treated patient: is there any connection?

metformin

patient

Digestive hemorrhage caused by a Meckel's diverticulum

treated


Input: Our findings reveal that even in patients without a history of seizures, pregabalin can cause a cortical negative myoclonus.

cortical negative myoclonus

pregabalin

patients without a history of seizures

cause


Input: We describe the first documented case of azathioprine-induced severe myelosuppression due to thiopurine methyltransferase deficiency in autoimmune liver disease.

azathioprine

severe myelosuppression

severe

induced


Input: We report five cases of carboplatin (CBDCA) hypersensitivity after weekly low-dose paclitaxel (60 mg/m2)/CBDCA (area under the concentration curve = 2) therapy in patients with recurrent ovarian cancer receiving multiple platinum-based chemotherapy.

carboplatin (CBDCA) hypersensitivity

weekly low-dose paclitaxel (60 mg/m2)/CBDCA (area under the concentration curve = 2) therapy

multiple platinum-based chemotherapy

patients with recurrent ovarian cancer

after


Input: The patient was placed on omeprazole after his first cycle of high-dose methotrexate for stress ulcer prophylaxis, and it was discontinued before the start of the first day of the patient's second round of high-dose methotrexate.

The patient

methotrexate

prophylaxis


Input: Because the patient had been taking lovastatin for the past 12 years, the possibility that the rhabdomyolysis may have been caused by a drug interaction between lovastatin and a concomitant drug was evaluated.

the patient

rhabdomyolysis

lovastatin

possibility

caused


Input: Ibopamine-induced reversible leukopenia during treatment for congestive heart failure.

Ibopamine

leukopenia

induced


Input: A 71-year-old man with paroxysmal atrial fibrillation who had a previous anterior myocardial infarction exhibited granulocytopenia 8 days following the administration of oral sustained-release procainamide (750 mg/day).

A 71-year-old man with paroxysmal atrial fibrillation who had a previous anterior myocardial infarction

oral sustained-release procainamide (750 mg/day)

granulocytopenia

exhibited


Input: Clinicians should be cognizant of this possibility and consider a diagnosis of HDAs in patients with ongoing thrombosis who are receiving heparin therapy.

heparin

HDAs

thrombosis

patients

possibility

receiving


Input: Rifampin-induced hypothyroidism without underlying thyroid disease.

Rifampin

hypothyroidism without underlying thyroid disease

induced


Input: Paradoxical precipitation of tonic seizures by lorazepam in a child with atypical absence seizures.

child with atypical absence seizures

lorazepam

Paradoxical precipitation of tonic seizures

precipitation


Input: Peculiar nail-changes in a 70-year-old woman with rheumatoid arthritis occurring after approximately 1 year of penicillamine treatment are described.

Peculiar nail-changes

penicillamine

a 70-year-old woman with rheumatoid arthritis

after


Input: Cutaneous vasculitis secondary to ramipril.

ramipril

Cutaneous vasculitis

secondary


Input: Multiple mechanisms for ciprofloxacin-induced nephrotoxicity have been proposed.

ciprofloxacin

nephrotoxicity

induced


Input: Pregabalin was added to clozapine in 2 patients with schizophrenia, who both suffered from severe anxiety symptoms.

Pregabalin was added to clozapine

2 patients with schizophrenia, who both suffered from severe anxiety symptoms

in


Input: Severe hyperkalemia as a complication of timolol, a topically applied beta-adrenergic antagonist.

Severe hyperkalemia

timolol

a topically applied beta-adrenergic antagonist

Severe

complication


Input: Amphotericin B overdose in pediatric patients with associated cardiac arrest.

Amphotericin B overdose

pediatric patients

cardiac arrest

associated


Input: Of particular interest is that toxicity only occurred during the second course of FLA and sixth course of Ara-C containing chemotherapy.

toxicity

second course of FLA and sixth course of Ara-C containing chemotherapy

occurred


Input: The literature search found 12 cases of radiation recall caused by gemcitabine.

gemcitabine

radiation recall

12 cases

caused


Input: Two heroin addicts, aged 34 and 19 years, developed ballistic movements after intravenous heroin overdose.

ballistic movements

intravenous heroin overdose

Two heroin addicts, aged 34 and 19 years

developed


Input: Successful challenge with clozapine in a history of eosinophilia.

clozapine

with


Input: CASE SUMMARY: A 57-year-old female with cardiomyopathy and "sulfa" (trimethoprim/sulfamethoxazole) allergy documented as pancreatitis presented with symptoms consistent with pancreatitis after use of furosemide.

A 57-year-old female with cardiomyopathy and "sulfa" (trimethoprim/sulfamethoxazole) allergy

pancreatitis

furosemide

after use


Input: Acute intravascular hemolysis developed when a diabetic patient, previously treated with glyburide, was started on another oral sulfonylurea drug, chlorpropamide.

chlorpropamide

Acute intravascular hemolysis

a diabetic patient

treated


Input: Intravitreal triamcinolone may have had an influence on the exacerbation of retinochoroiditis in the posterior pole of the patient.

exacerbation of retinochoroiditis in the posterior pole

the patient

Intravitreal triamcinolone

may

influence


Input: We evaluated a patient who developed a psychotic disorder after 4 months of isoniazid prophylaxis for a positive tuberculosis tine test.

patient

psychotic disorder

4 months of isoniazid prophylaxis

developed