Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
Q1ZXH2 | 2.7.11.1 | ACT_SITE 747; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSQDIQTQNSYSDELYSSQIYSTQQPQQPQQQPQQQQSTFSSQQSQSSSYDFIYSTPQIHSQNSQNSQFSQNPLYDDFIHSTQNSYSQRVSSQRSYSQKSSSSQISFSQIPSSQIQSSQIPSSQIHSSQIPSSQNQSSQKSQFSFSQIPSSQIPSSQKRFFQSQNDDFVPSSQVTSLQDICLPQPIQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQCQPQQQQTQQQQQQQQQQQQQQQQQQQQQQQQQQTQQQQQQPQEDDDDYDDYDGYDNYEDFVYNEGEEGEEDYEDYEQENDDDDDEDEDDDDDDDDDDDDEE... | 99 |
W1PYS1 | 2.4.1.18 | ACT_SITE 447; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"; ACT_SITE 502; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1" | MAWSLAGIRSPATYMGSRITGDKKDRAFPVVLQKPFLRKILAGNGSSLEADSTCRTLAMSEKVLVPGIQSDNEASSNDQLELSEATSDEEEMIEEDEPKQMGTIIEALPRTIPPPGTGQRIYEIDPLLEGFRGHLDYRYRQYKNLRLLIDQNEGGLDAFSRGYEKFGFNRSESGITYREWAPGAKSASLIGDFNNWNPNADVMTRNEFGVWEIFLPNNADGSLSIPHGSRVKIRMDTPMGIKDSIPAWIKYSVQAPGEIPYNGIYYDPPLEEKYEFKHPQPKRPKSLRIYEAHVGMSSIEPKINTYAGFRDDVLPRVKRL... | 73 |
A0A1D6IN03 | 3.1.1.11 | ACT_SITE 442; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MRRPPKPKRVAAAAKLPLPLTATFLSLVLLPLGFVATHRAFSGVVSAASTPAAKRVLLEDDGRASRGAAANASAGAEHAAAVERHCAGTLHRDVCASTLGSIPDLARKPAREVISAVVARAASAVRASASNCSAYLRRPAGALRVRDRLALADCVELLGHTLAQLGTAEAELSAGNFTAAEAEVESESLAAVQTVLSAALTNQYTCLDGFAGPSASEDGRVRPYIQGRMYHVAHLVSNSLAMLRRLPQRRRRRQGRGALELEGYGRVRRGFPSWVSGADRRRLQQQQVVPGPDLVVAKDGSGNFTTVGEAVAAAPNNSET... | 125 |
D8SVB0 | 1.11.1.7 | ACT_SITE 49; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MIDAAAGGLTPGFYQQSCPNAESMTRSTVQRLTLLDPTLSAALVRLVFHDCQVQGCDGSILLATTKNQSFSPVTTSELASSNNFGIRRLDAIDRIKSVLEASCPGVVSCADIVVMAARDAIALSGGPTIPILTGRRDGTTASAKQADDSLFPPQTPLDRVLSVFQSQGLDTVDAVALLGGHTLGVSHCPSVVNRLYPRMDSSLPLGFGASLRLRCPATIPMNNLSIIANDFTNLAFDNRFYSDVIASTGVLTVDQQLASDPRTRGIVNQFAADRAAFFRAFARGFQKMSQLNVLTSNAGQVRRSCRTAN | 14 |
Q7K6A1 | 3.5.1.98 | ACT_SITE 139; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1" | MSNRKKVAYFHDPDIGSYYYGAGHPMKPQRIRMTHSLIVSYNLYKYMEVYRPHKSDVNELTLFHDYEYIDFLSSISLENYREFTYQLKRFNVGEATDCPVFDGLFQFQQSCAGASIDGASKLNHHCADICVNWSGGLHHAKMSEASGFCYINDIVLGILELLKYHARVMYIDIDVHHGDGVEEAFYVTHRVMTVSFHKFGDYFPGTGDITDVGVNHGKYYSVNVPLNDGMTDDAFVDLFKVVIDKCVQTYRPGAIIIQCGADSLTGDRLGRFNLTIKGHARCVEHVRSYNIPLLVLGGGGYTIRNVSRCWAYETGVVLNK... | 184 |
A0A072U5L0 | 3.1.1.11 | ACT_SITE 399; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MGWKAFSIATTFSIFFLLPFFAFLATANDTLVPPETICKSSQYPSYCTNLLPKQNAKVHDFARFSIQKSMFQSQKFLNSLNFYLESTFTKETINALKDCLFLSQLTSQYLSKSNYVALKNTNETLYTSQVDDTQTLLSAVITNHQTCLDGLITVANSNLTIENDLISQLSNDSKLYSVSLDLFTKGWVHEKKNKTLWNSTGLHPRFKNGRLPMKMSNRTRVIYHSSRGGGETHDDDDQSGVLVRDIVVVSQDGSGNFTTINDAVAAAPNNTINATNGYFMIFIKEGVYEEYVSIPQNKAYLMMIGDGINRTIITGNHSVG... | 125 |
G7LJK6 | 3.6.1.1 | ACT_SITE 7; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR031051-1"; ACT_SITE 9; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR031051-1" | MVIVVLDFDRTIIDDDSDRWVINQMGLSDLFNQLRATMPSWTSLMDRMMEELHSKGITTDKIANCLKTAFLSPNIVSAIKSAHSLGCDLRIISDANLFYIQTILEHHNILGCFSQINTNPTFVDEKGRLCITPFHDSKTLPPHDCQLCPSNMCKGLVIDRIRGSLPESKTRFIYVGDGAGDYCPTLKLEGGDFVMPRKNYPLWNRICSDPKLVHAKVHDWSNGEELESILLNLVNKAT | 188 |
A0A078H6T3 | 3.1.1.11 | ACT_SITE 408; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MASSINEIFSRDNFKKNKKLVLLSAAVALLLVAAVTGIAAGASKANGNTKRPLSPSSHAVLRSACSSTLYPELCVSAVAISGGVKLTSQKDVIEASLNLTTTAVEHNYFTVKKLIKNKKGLTPREKTALHDCLETIDETLDELHETLEDLQMYPNKKTLREHAGDLKTLISSAITNQETCLDGFSHDDADKKVRNFLLKGQHMCSNALAMIKNMTDTDIANFELKAKLSSNNQLDAEGWPTWLSAGDRRLLQGSSVRADATVAANGSGKFKTIAAAVAAAPDNSKRRYVIHIKAGVYRENVEVSKKKKNIMFMGDGRTRT... | 125 |
A0A9J7LW94 | 3.1.4.11 | ACT_SITE 266; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"; ACT_SITE 302; /evidence="ECO:0000256|PIRSR:PIRSR000956-1" | MFFCMHKYLANLPKDKLKEMVQFGPPDIPVENKTVTVVYGPDMVNISFINFVSNSEGVAKIWTDSLLKIATNVLALNASPMQNLKKVYAKLIVKDLTKEGKLPVKNVIKLFSTSKEERKRVEAALATCSLPTGKNDVINVEKFFFEDFITIVRKVCPRPELDKVFAEVGTKKPYLTMEQVVDFLNKGQRDPRLNEILYPYANNKKALDIISRYEPNKSYANKGHLSVDGLYRYLMSDENTMVDPVKFDLSDDMTQSLSHYFINSSHNTYLTGGTVCCSSLIWMSMCGAGLLDGNDNEPIITHGYTMCTDVLFKDVVEAIA... | 153 |
Q7KTS4 | 3.5.1.98 | ACT_SITE 140; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1" | MTDRRVSYFYNADVGNFHYGAGHPMKPQRLAVTHSLVMNYGLHKKMKIYRPYKASAQDMLRFHSDEYIAYLQQVTPQNIQCNSVAYTKYLAHFSVGEDCPVFDGLFDFCAMYTGASLEGAQKLNHNHSDICINWSGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDVHHGDGVQEAFYLTDRVMTASFHKYGNYFFPGTGDMYEIGAESGRYYSVNVPLKEGIDDQSYFQVFKPIISAIMDFYRPTAIVLQCGADSLAGDRLGCFSLSTKGHGECVKFVKELNVPTLVVGGGGYTLRNVARCWTHETSLLV... | 184 |
H9G5L9 | 2.1.1.320 | ACT_SITE 442; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR015894-1"; ACT_SITE 451; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR015894-1" | MAATTATTPAVGPGSAAARVSCGRDLNCVPEVASTLGAVARQGFDFLCMPIFHPRYKREFFQEPAKKRPGPQTRSDLLLSGRDWNTLIVGKLSPWIRTDSKVEKVRRNSEAAMLEELNFGAYLGLPAFLIPLTQADNPNLAHVLCNHISTGHHTSMFWMRVPLLAPEDLRDDVIENEAIQEDGEECSGEEKTWQWWHNFRTLCDYNKRVAVALEVGADLPSNHVMDRWLGEPIKAAILPTSIFLTNKKGFPVLSKMHQRLIFRLLKLEVQFIITGAHHHPEKEFCSYLQYLEYLSQNRPPPSAYELFAKGYEDYLQSPLQ... | 44 |
A0A5F5PWV5 | 2.7.11.13 | ACT_SITE 504; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000551-50" | MSPFLRIGLSNFDCGSCQPCQGEAVNPYCAVLVKEYVESENGQMYVQKKPTMYPPWDSTFDAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNARYFLEMSDTKDMSEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQARCLRDTEHIFREGPVEIGL... | 100 |
A0A2G2XVM6 | 2.3.1.48 | ACT_SITE 542; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MRRKYKCLCQLKNVVRSVLFLSLLQLETYISAETNARFETARPNKADFIVEEGKEVALATPVSVESESKMEVQTTESVAETVTPVHKYYYEPVSGKKFWSMPEVLRFLKTGSMRKKSTGGDATPSEIPNSKKQKKSSLKKEKDKTTSFYSDSLNPPQSVCWVLADSSADTWAPFVHGNMVPEGQRQKWDAVFSTVSQRNANRNSQKVLHLYSVHDVQVILSQVLAMEAVTNACIGQQDAETRVVDEQEEDQLFVASCLTSSVSSNSWLIDSGCTNHMTCNKDLFKDLSPTKVTKVRIGHGGYIPAKGMGTITIETQSGTK... | 61 |
W5MET1 | 3.2.1.143 | ACT_SITE 708; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 726; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 727; /evidence="ECO:0000256|PIRSR:PIRSR607724-1" | MATKTVLGYIQRWRKAGVRCCSFKSHRTYCQKDVTLLTKFLFMTTLSDCEPSRKRLRLEVNITSTSTKPTTLLTARRILNKEITLGPSSSGQQIRDKQKIAHAYPVRIKDVTMDTEKLVSCKGLEKTMMASCTASGKESVQLRPQPNENMLSSTKNETLGEKGKEKMDSFKTTTYLEGVNLQSVGIQEMCTPTSSSTTRMKATCQESSASCEQKSQKPGTLDDWFIKPGSKATAQRAELSAAPTPEEQPQSGEDCGRQDVEMVSPESPSGKAFQPEDAEDEGRPCRASESWGTVAGDARASATGRRAPGAKPLSHPGAGA... | 159 |
B8BZC2 | 1.1.1.205 | ACT_SITE 344; /note="Thioimidate intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|PIRSR:PIRSR000130-1"; ACT_SITE 440; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|PIRSR:PIRSR000130-1" | MSPSKKQKTDNGALWELDEETMNSGAVGFTASQIFMKNPACVAYTYDDVIMMPGHINFGLNEVDISTKLTKKISLKVPFVSSPMDTVTEHKMAISMALQGGIGIIHSNFTMEDQAEEVRKVKRFKNGFITDPICLSPSSTVGDVIELKEKHGYSGIPITDNGRMGGKLVGIVSNRDITFVDDRTMKLEEIMTPRDKLSVAKQGVELIEANEILKETKKGKLPVVNDADELVALIARTDLLKNIEFSQASKDHVTKQLLVGAAIGTRLEDRDRAAALVEAGVDVIVVDSSQGDSLYQLDIVKHLKASHPKLQVIAGNIVTP... | 3 |
A0A0K9PMR3 | 3.4.19.12 | ACT_SITE 82; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"; ACT_SITE 157; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1" | MSWCTIESDPGIFTELIQQMQVKGVQVEELYSLDMDSLEKLWPIYGLIFLFKWRPDEKDGRPVIRDPIPSLFFASQVINNACATQAILSILMNCQNIEIGPELSMLKEFTKNFPPDLKGLAINNCEAIRTAHNSFARPEPFVSDEQKTAGNDDEVYHFISYLPVDGMLYELDGLKEGPICLGQCSREQDSLEWLHMVQPAIQERIERYSQSEIRFNLLAVIKNRKEMYTSELKELRKRREYILQKLQLAQNERSDHMYAMDDSNSVIEALNGSLSEVSSSIEMVSEKLVLEEEKQKKWKVENIRRKHNYIPFLFNFLKIL... | 175 |
A0A8V0ZRC8 | 3.1.1.3 | ACT_SITE 177; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1"; ACT_SITE 200; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1"; ACT_SITE 287; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1" | MCDKRMVVGTWIIAFYLLGTVAGEEVCYPRLGCFSNDPPWSGIPGRLLTGLPEPPEEMNISFSLYTRETGNNSQVISAINSSTIQNSHFSSRRRTSFIIHGFSSTGKKGWVVEMCLLLLEVENMNCIAVDWKEGAKGTYVCAVNNIRVIGAEVAYFIKTLQKLFRYSPREIHLIGHSLGAHTAGEAGRRVRGIRRISGLDPAGPYFEGTPPEVRLDPTDANFVDVIHSNAAHFPATGFGMYNTTGHLDFYPNGGTQMPGCNDLLLEMKRSDFEALIADTTIFGSCHHSRSHEYYFKSILYPTGFVGYPCETDEDFKSGVC... | 128 |
A0A078IA53 | 1.11.1.7 | ACT_SITE 71; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MANAKMPFCLLAFFCLLLQLFSIFHIGNAELEMNYYRESCPRAEEIIRQQVETLYYKHGNTAVSWLRNLFHDCVVKSCDASLLLETARGVESEQKSTRSFGMRNFKYVKVIKDALEKECPSTVSCADIVALSARDGIVMLKGPKIDMIKTGRRDSRGSYLSDVETLVPNHNDSLSSVLSNFNSMGIDVEATVALLGAHSVGRVHCVNLVHRLYPTIDPTLDPDYALYLKNRCPSPNPDPNAVLYSRNDRETPMVVDNMYYKNIMAHKGLLVIDDELASDPRTAPFVAKMAADNGYFHEQFSRGVRLLSETNPLTGDQGEI... | 14 |
F2EEV5 | 1.11.1.7 | ACT_SITE 77; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MARVPLLAALVVAMAVLVASSLGPRASAAEPPVAPGLSFDFYWQTCPRAESIVREFVQEAVRKDIGLAAGLLRLHFHDCFVQGCDASVLLDGSATGPGEQQAPPNLTLRPSAFKAVNDIRDRLERECRGAVVSCSDILALAARDSVVVSGGPDYRVPLGRRDSRSFASTQDVLSDLPGPSSNVQSLLALLGRLGLDATDLVTISGGHTIGLAHCSSFEDRLFPRPDPTISPTFLSRLKRTCPAKGTDRRTVLDVRTPNVFDNKYYIDLVNREGLFVSDQDLFTNAITRPIVERFAQSQQDFFEQFGVSIGKMGQMRVRTS... | 14 |
A0A059C7C8 | 1.1.1.205 | ACT_SITE 317; /note="Thioimidate intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|PIRSR:PIRSR000130-1"; ACT_SITE 414; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|PIRSR:PIRSR000130-1" | MEFEDGYSAQKLFHQGYSYTYDDVIFLPGYIGFPVEQVDLSTKLTRNISLNIPCVSSPMDTVTESSMARAMAALGGIGIIHANIPPSDQASLVKAAKSSRFPVLSNPVFRSPSDSIISLEYFADAPCILVIDSGDCRGKLLGYVTKSGWMNLTDKETRLANYMVKSSDFAPWDCDLAKMICYFEEKAGNEFTPIVKGGEIVDVAGREDVERLRGYPRLVGGGSVDANGEWMVGAAIGTREADKERLQHLIKAGVNVVVLDSSQGNSLYQIDMIKYVKKTYPELDVIGGNVVTMYQADNLIKAGVDGLRVGMGSGSICTTQ... | 3 |
Q24210 | 2.7.11.17 | ACT_SITE 141; /evidence="ECO:0000250" | MTEDEILFDDVYELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLSTADLKREATICHMLKHPHIVELLETYSSEGMLYMVFEFMEGSDLCFEVVRRAVAGFVYSEAVACHYMRQILEALRYCHENDILHRDVRPACALLATVDNSAPVKLGGFGSAIQLPGTRETIETHGRVGCPHYMAPEVVTRRLYGKGCDVWGAGVMLHVLLSGRLPFLGSGVRLQQSVARGRLSFEAPEWKSISANAKDLVMKMLAANPHHRLSITEVLDHPWIRDRDKLQRTHLADTVEELKRYNARRKLKGAVQAIAGGTNMDP... | 101 |
B8E0S5 | 2.7.1.11 | ACT_SITE 128; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00339" | MIRRIGVLTSGGDAPGMNSAIRAIVRFGISKGIEIIGIERGYQGLIEGEFKVLSRDDVSEIVQKGGTILRTARSDEFREEEGQKKAIENMEKHGLDALIVIGGEGSLKGAYDLFKKGINVVGIPGSIDNDVWGTDFSIGFDTACNNVIDAINKIRDTAAAHERTFVIEVMGRECGFIAFTSGLVSGADIILIPEVPIDFPYITEKLRERQKRKKRHNIIVVAEGVGSAYFIGKQIEDKLGISTRIVVLGHIQRGGSPSVFDRNMATFMGVEAIKRLLNGEGGVMIGWQKNSPVPISLEEVSKYKKRVPPELYWEVECLW | 84 |
A0A2K1JZS6 | 3.1.1.11 | ACT_SITE 228; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MARLWGSIFILVFFSLVSSLELVSSASEVTSSRSKAIASFQSWVDRVGANHSAFENTAKSSGSTGDLSRKVAEGVIVVDQSGAGHYKTINEAINAVPLHNKYAVTIKVNPGIYIERVMVPKSKWRITLQGSGRDVTKITSRNAAGDTGTTYTTSTFGVSAPYFTARNITFENSSPLQIGGAQQQAVALRTTGDFNAFYGCAFLGQQDTLYDDRGRHYFKESLIVGSVDFIFGDGKSLYQNCELRVLPSSGGSLTAQKRLSFSEDTGYSFVNCKITGSGPSTVYLGRAWGPYSRVVFAYSEFADIINPVGWYNWADPARER... | 125 |
W5N5D4 | 3.1.4.11 | ACT_SITE 327; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"; ACT_SITE 377; /evidence="ECO:0000256|PIRSR:PIRSR000956-1" | KMEKGGLLEPPVIKDYLVKGDRFTKWSDDSSRTSPVMMKMDPKGFYLYWTHQNKEMEFVDIATIRDTRSGKYARIPKNPKVRNVFNLDFPDSHHLAKTLTIVTGLDMVNLTYHNFFAYKENIPQNWAEDVLAIAYNPMRINACRQVFLEKIYVRISLQRNKDGKIPVKNIYKMFPADKKRVEAALAAAHLPKGKGDTMKPDVFTEAAFKSFLMNLCPRPEIYEIFTSYSAKAKPYMTKENFTKFINEKQRDSRLNETLFPLIKPEQVKNLIEKYEPTSSNANRGQISPEGLLYYLTGPETSTVTPDKLGIWQDMMQPLPH... | 153 |
B9H938 | 3.1.3.48 | ACT_SITE 127; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000941-50" | MPYLVRENLFIGNISDAAEVLQNGSAEITHILSVLSSVSISFFTEWRSGVIIPTKEIKKVCVGDEWRSCLAVNKVLYSLEYAGKELKLVRMAVPIRDMESEDLLDYLDVCLDFIQKTRKEGAVLVHCFAGVSRSAAIITAYLMKSEQLSLEDALESLRQSCESVGPNDGFLEQLKMFEEMGFKVDHASPIYKRFRLKALGEFYNRGEKIDSSKFGADPGVPTQVSSEEEASPNGGEKGIPAYHCKKCRRVVALQENVMDHVPGEGETSFAWSKQKSGNPLNKSDESECSSIFVEPLKWMTAVEGGMVEGKLSCAHCEARL... | 149 |
B9RSX7 | 1.11.1.7 | ACT_SITE 90; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MRRNYNIILLYLSLLLLAGLDVSNGKGGGHGRDDHDQQNGRGHGHGSDKQHGGKKVNSCPQLETISRDITWGRVASNPTLPAKLIRMHFHDCFVRGCDASILLDSTGNTKAEKEAIPNRSLTGFDVIDDIKAKLEEECPGQISCADIIALAARDAVSFQFGRPLWPVAFGRKDGRISLESEATRDLPSPAADFKTLLSQFRSHGLDVTDLVALSGAHTIGVGHCVIIAKRLFNFTGIGDTDPSLDKNYADFLKKQCSNPPNPTTTVEMDPGSSLSFDTNYFVAINHKKGLFQSDAALLTNPEAARLSSNFENPNVFFPRF... | 14 |
A0A0K9Q369 | 2.2.1.1 | ACT_SITE 495; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1" | MAASSSLTVQTFAANFISGNGSASSQCPSNRLLSTSRTSSFSGKPLRFSSSSSSCRTKKVYLQRRGLGVTRASAVETLKKKTATDELVEKSVNTIRFLSIDAVEKANSGHPGLPMGCAPMGHILYDEVMRYNPKNPYWFNRDRFVLSAGHGCMLHYSLLHLAGYDSVKEEDLKVFRQWGSCTPGHPENFETPGIEVTTGPLGQGIANAVGLALAEKHLAARFNKPDCEIVDHYTYVILGDGCQMEGISNEACSLAGHWGLGKLIAFYDDNHISIDGDTEIAFTEDVSSRFDALGWHTIWVKNGNNGYDEIRAAIEEAKTV... | 51 |
A0A2K1JPM5 | 1.11.1.7 | ACT_SITE 103; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKNLGVIGVVYGLMALATLQVASAWCPFAGRRSLLQAAAPAPLPARPTGPDPSNWTMLNYDFYTAGLPENACPSFQNIVKKEVAKATVLDSLTPAFLLRLFFHDCFVMGCDASVLINSTLLNLAEKDQTKSFSLNKFNVVDDIKTALEVACPGVVSCADILAAAAVECVEQSGGPHIDLAYGRRDGLESFAAAAATYMPGGFLRVQGLIESFQMAGLDEVDLVALSGAHTLGQARCSEFIQERFISPGSNSFRDSDYGLALQSYCAEGKNLGLDRKVTLDSNTSTIFDNGYFQTLVDGRGVLTSDNDLTLDNRTAPLVQL... | 14 |
Q9H8X9 | 2.3.1.225 | ACT_SITE 155; /note="S-palmitoyl cysteine intermediate"; /evidence="ECO:0000250|UniProtKB:Q14AK4, ECO:0000255|PROSITE-ProRule:PRU00067" | MDTRSGSQCSVTPEAILNNEKLVLPPRISRVNGWSLPLHYFQVVTWAVFVGLSSATFGIFIPFLPHAWKYIAYVVTGGIFSFHLVVHLIASCIDPADSNVRLMKNYSQPMPLFDRSKHAHVIQNQFCHLCKVTVNKKTKHCISCNKCVSGFDHHCKWINNCVGSRNYWFFFSTVASATAGMLCLIAILLYVLVQYLVNPGVLRTDPRYEDVKNMNTWLLFLPLFPVQVQTLIVVIIGMLVLLLDFLGLVHLGQLLIFHIYLKAKKMTTFEYLINNRKEESSKHQAVRKDPYVQMDKGVLQQGAGALGSSAQGVKAKSSLL... | 57 |
M4CM11 | 3.1.1.11 | ACT_SITE 186; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MSMKVVSSLACLFVTVLSLNEKYTHFHQASLVLVVDLNGGGNFTTVQSAIDAVPDSSSFRTLIVINPGIYREKVTVHKKKTNVVLQGKGYQKTIIEWNDTALSSGGTFYSFSFAVYADNFVAHNVSFVNTAPEPRPEVKGAQAVAMRLQADKSAFYGCGFYSAQDTLLDSEGRHFFKECYIQGSIDFIFGNGRSIYQARRTCMSIAKETSSGISGIITAQARDSESDQTGFSFVNCTISGTGKIWLGRAWRTFSTVVFSNTYMSEVISPDGWNNFGNTTRDRTVTFGEHKCFGEGANYTKRVAYGKQLTDAEAAKFTDIS... | 125 |
A0A9J7LUU8 | 2.7.10.1 | ACT_SITE 600; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MTAEGSASHIFTVVLPDMTIDNVRQLYENRALIAGQVGLKLLNVSKTDSGTYELNMNFENARSLIEQTTLDVQYPPTDTKVTTMDGSKTTTKSMLLKQGDTLRLKCTTDSNPKSSFSWRRLNNTLSPVAEVNATSGALTIHDVRKNDTGIYQCRAHNGLDPDGRWNVKVTIQSDEPVFLPQSNVTTRVSKITPRWVIPTFTSVAFALWLSCITILWIYTSRRKNKKHNNDQWAHIFVATEDYYPEYQSPSRAALLLSSASSEEKMADPVVREFWDRLMTMDADRVLVCLQEKEILKVDDAAGIRRALSVVETLLETVCVL... | 97 |
A0A8R1U7Z8 | 2.7.11.1 | ACT_SITE 141; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50"; ACT_SITE 496; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50" | MNEPSEKVSMENFALLKVLGKGAYGKVFLVRKIGGSDHNTIYAMKVLRKTRVVSKQKTLEHTLAERQVLERLRGVPFLVQIYYAFQTDTKLHIVMEYVRGGELFTHLCSRGAFDLSSAKFVIAELIMAIDILHQKKIIYRDLKLENILIDEEGHIKLTDFGLSKLILPEGLMRANSYCGTIEYMSPEVVNRPEDGYTEVVDWWSMGVIAFELLTGCSPFTVDGGANSSRDIAKRILTKPVPFPKTMDAQAKTFITSLLDKKLERRLGFKGVNEIKNHPFLADIDWDAAANRHMKPFTVPSLTSEVDVGNFSNEFTNQPPL... | 99 |
O65440 | 2.7.11.1 | ACT_SITE 836; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MADKIFTFFLILSSISPLLCSSLISPLNLSLIRQANVLISLKQSFDSYDPSLDSWNIPNFNSLCSWTGVSCDNLNQSITRLDLSNLNISGTISPEISRLSPSLVFLDISSNSFSGELPKEIYELSGLEVLNISSNVFEGELETRGFSQMTQLVTLDAYDNSFNGSLPLSLTTLTRLEHLDLGGNYFDGEIPRSYGSFLSLKFLSLSGNDLRGRIPNELANITTLVQLYLGYYNDYRGGIPADFGRLINLVHLDLANCSLKGSIPAELGNLKNLEVLFLQTNELTGSVPRELGNMTSLKTLDLSNNFLEGEIPLELSGLQK... | 99 |
O67024 | 1.11.1.24 | ACT_SITE 49; /note="Cysteine sulfenic acid (-SOH) intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00401" | MEVVSLPRLGEPAPAFEAQTTFGPVKFPDDFKGQWVVLFSHPADFTPVCTTEFVAFAKNYEEFKKRNVQLIGLSVDSNFSHIAWVMNIKEKFGIEIPFPIIADHNMEVAKKYGMIHPAQSTTFTVRALFVIDDKGILRAMIYYPLTTGRNIREVIRLVDALQTADREGVATPADWVPEPQTWEFTEENTKVIVPPPTTYEDAVKRLQEGYECADWYICKKKV | 12 |
A0A1L8GLW3 | 2.7.10.2 | ACT_SITE 989; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000636-1" | MAFCAKMRNSKKIEVDIADKDGLEVSFYLPDKTTIYHPQGEFTAEDLCIAAALHCNISPLCHNLFALYNERDRIWYPPNHIFKIDSNVSLKLHYRMRFIFTNWHGTNENEASVWRHYPKKRDGYDKKQTQEGTPLLDASSLDYLFAQGQYELVKCLAPVREPKNDQEVHEIENECLGMAVLAISHYAMKRNIQLPDLPRDISYKKYIPETLNRTIKQRNFLTRMRINNVFKNFLKEFNNKTLCDSSVSPHDLKVKYLSTMETLTKNYGAEIFETNSLVIKSENEQNGFNISDYDNMLHYEVLVAGNSGIHWRRKPTCTAS... | 98 |
F6R3K0 | 3.4.19.9 | ACT_SITE 151; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 261; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 261; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1" | MMMMMTTTTMTMGRPCGALCGALCGLLGALLLGPARTAPPRGGSAPGNDRPVLGILMQECDFKAFQSLGKYYIAASYVKYLESAGARVVPISLTLSEEEYETLFQSINGVLFPGGSVDLQTSQYARVAKLLYNKALKANDQGDYFPVWGTCLGFEELTFLASGEKLLTLTNTHGLALPLNFTSAAKESRLFQNFPSDLLEAFASEPLTSNFHYWSVSTQNFTRNKGLHDFYKILTTNVHGQFEFVSTMEAYAYPIYGVQWHPEKNAFEWKNVTGIPHSPLAMRTAYYMADFLVNEARKSQHRFASEETELKALIYNYAPV... | 176 |
A0A2G2XYC5 | 3.1.1.11 | ACT_SITE 399; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MSENNRKRNFVIIGVCSLILVAMVVVAVVTINWKDKDDNAQDVSTTKKAIESVCQTTHYQQTCVESLESSADGSSDPKVLIEKSFQATIKRIKEAIDKSTVMQKLEKDPRAKMALDNCEKLAGRAVNDLNRTLIKFESFELNDLGLWIADLKIWLSGAITYQETCLDGFEKTTGETGEKMKKALNASMELTSNALSMITEISAVFTSLNAGSNRRRLLFDEHGIELLPDWIDMGRRRLLAVNISKEIKPDMVVAKDGSGKYKTINEALKNIPLSRNETFVLYIKQGVYNEKVEITSLMTHLVIVGDGPTKTRITGNRNFK... | 125 |
C0LGX3 | 2.7.11.1 | ACT_SITE 817; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MLTNTNLFFFLSLLLLSCFLQVSSNGDAEILSRVKKTRLFDPDGNLQDWVITGDNRSPCNWTGITCHIRKGSSLAVTTIDLSGYNISGGFPYGFCRIRTLINITLSQNNLNGTIDSAPLSLCSKLQNLILNQNNFSGKLPEFSPEFRKLRVLELESNLFTGEIPQSYGRLTALQVLNLNGNPLSGIVPAFLGYLTELTRLDLAYISFDPSPIPSTLGNLSNLTDLRLTHSNLVGEIPDSIMNLVLLENLDLAMNSLTGEIPESIGRLESVYQIELYDNRLSGKLPESIGNLTELRNFDVSQNNLTGELPEKIAALQLISF... | 99 |
Q5U1F9 | 1.11.1.7 | ACT_SITE 71; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MASSPTMLVVMCSSLAMAVILSSSSPAMAQLDVGFYSKTCPKVEEIVREEMIRILAVAPTLAGPLLRLHFHDCFVRGCDGSVLIDSTASNTAEKDAPPNQTLRGFGSVQRIKARLDAACPGTVSCADVLALMARDAVALSGGPRWAVPLGRRDGRVSAANDTTTQLPPPTANITQLARMFAAKGLDMKDLVVLSGGHTLGTAHCSAFTDRLYNFTGANNAGDVDPALDRSYLARLRSRCASLAGDNTTLAEMDPGSFLTFDAGYYRLVARRRGLFHSDSSLLDDAFTAGYVRRQATGMYAAEFFRDFAESMVKMGGVGVL... | 14 |
Q9FXQ3 | 2.7.11.1 | ACT_SITE 212; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MGNACGGSLRSKYLSFKQTASQRHDTDDNNNAAAADSPKKPSRPPAAAKTDDHPVSASAPAAAMRRGQAPADLGSVLGHPTPNLRDLYAMGRKLGQGQFGTTYLCTELSTGVDYACKSISKRKLITKEDIEDVRREIQIMHHLSGHKNVVAIKGAYEDQLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTRIIVGVVEACHSLGVMHRDLKPENFLLANKDDDLSLKAIDFGLSVFFKPGQTFTDVVGSPYYVAPEVLLKHYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGFIDFDSDPWPVISESAK... | 99 |
A7S4Y9 | 2.7.10.1 | ACT_SITE 138; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MEFPRHDLEALRTLGNGSYGRAFLARASGIKDGERETMVVVKSLIAKDDIVREDFTRELESLVNMEHSNVVSLLGVCRDSEPFYMIFECFEKGDLKQFLLSCNDNGRSTLTSSHKLTMCSNIVSGMSYLAANKFVHKDLAARNCMVTKDLQVKIGFLNLSYDLYNAEYYRFNNILIPLRWMPSEAIFHDDFTEKSDVWSFGVLAWEIYSLGQIPYTDRSDEEVLKCVKDDLRLPKPDNCPDNMANVMKKCWEPNPNDRPNFDMIFAEMSEVAVDSHV | 97 |
Q9T1X2 | 3.2.1.17 | ACT_SITE 37; /note="Proton donor/acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_04136"; ACT_SITE 46; /note="Proton donor/acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_04136" | MAGIPKKLKAALLAVTIAGGGVGGYQEMTRQSLIHLENIAYMPYRDIAGVLTVCVGHTGPDIEMRRYSHAECMALLDSDLKPVYAAIDRLVRVPLTPYQKTALATFIFNTGVTAFSKSTLLKKLNAGDYAGARDQMARWVFAAGHKWKGLMNRREVEMAIWNIRGADDLRQ | 160 |
Q7RZD3 | 2.7.11.1 | ACT_SITE 793; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MDGQLSLLSPTSSSSTSHSRKRLTKKQRPPSANHRTSSSFNVESLRIDAQSLDSKRSASSLRQGPNCNQSPSLARTVSVPVSVPSNAPAHTKASDLSLPRSHTTRSQSANRPYNPTQTIPTNRFILSPASSSQPQTQSPPYPSAVASTTVTSSRNKDTSKQYDPLDSCIGSFDQNKLSTDELIGAPFDGNAILSRIEATKLSAAPAPTSTTTIAHSNNISPRRVAPPPPPPPPALSRSNTDSKAARSSKPSKSPKSTISNKTMGASSFRHSASFSSAEQLPPSEKPSKSESSSSSNKRHSGDGKESRVPGMLRKKSGFSG... | 99 |
F4IS56 | 2.7.11.1 | ACT_SITE 319; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MENITAQLKRGISRQFSTGSIRRTLSRQFTRQSSLDPRRTNMRFSFGRQSSLDPIRRSPDSSKSDDEPHMSVPENLDSTMQLLFMASKGDVRGIEELLDEGIDVNSIDLDGRTALHIAACEGHLGVVKALLSRRANIDARDRWGSTAAADAKYYGNLDVYNLLKARGAKVPKTRKTPMTVSNPREVPEYELNPLEVQVRKSDGISKGAYQVAKWNGTRVSVKILDKDSYSDPERINAFRHELTLLEKVRHPNVIQFVGAVTQNIPMMIVVEYNPKGDLSVYLQKKGRLSPSKALRFALDIARGMNYLHECKPDPIIHCDL... | 99 |
A7REZ3 | 3.4.19.12 | ACT_SITE 309; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR016308-1"; ACT_SITE 745; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR016308-1" | LSKVSMEQLASANIRVPGGGDKVYKDECVYCFDSPESESGLYVCLSTFLGCCLRHVTLHISKTNKNVFMHLKKIRKESTQEESKDAPPKKKPTRLGIGVEGGFDGERQYFAIYFDFLSLQVQLSLAGVLAADTSAYKEQVASWDGEKRVVSKHAESLLQLDNGVRIPPSGWKCALCDKTDNLWLNLTDGSILCGRKYFDGSGGNNHALESYKNTKYPLAVKLGTITPDGGDVFSYDEDDMVEDPHLAKHLSHFGINITQMEKTDKTMAELEIDINMRVREWDVIQEAGKKLTPMYGPGFTGLRNLGNTCYMNSVLQVLMT... | 175 |
A0A072TPR9 | 3.1.1.11 | ACT_SITE 451; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MSNSSTSFIVLLLLSLFLISPFLLQAQTSSPSPSPSHSSSPSSSPSPSHSSSPSPSPSPSPSHSPPPPSTSTSSSKACKSTLYPKLCRSILSSIRSSPTDPYHLGKFSIKQSLKQAKKLSKVFKDFLKKHHHSTSLNHAEIAALDDCSELNQLNVDYLELVRDELKSADSSSFNNTDVLVEKVETYLSAVATNHYTCFDGLVVTKSNIANALAVPLSNVTQLYSISLGLATQALSKNIKKRKTRKQGLPTKAYKVRQPLKKLIKLLHTKHSCSNNSSNCLRHERILKESENRGILLKEYVIVSLDGTENFTSIGEAIDAA... | 125 |
A0A9J7MTV4 | 3.2.1.17 | ACT_SITE 36; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR608597-1"; ACT_SITE 49; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR608597-1" | MSKAPVILLASLIGCLSVVHAGYVPDACINCICYVESGCRMPDPICHMDTKSLLCGPFRLRHSHWLDSLQKGGPLMNDYQRCAASWACSRQALDAYLQLYAVSSRLGHSPTCQDFARIHHEGPNGFKSAATIEYWEKVKKCLERGPTL | 160 |
Q8T3L0 | 2.3.2.26 | ACT_SITE 931; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MLPYKVICRSPHLTDMLVKLLASLSTELPKEEELLPLSDQMPPLVPIGPVQRAGAAAAAAHPPPPQPPAENTATATEIGDGLAANIEEQAAPASGNPASGDSNAGAKRTQLPTLSVALPVTPSKPRRKIYSKNFSQLQLVIEVLTHQCGTTEGLDNVAKLIVNLTQCSQASSAIFIQYLTAAILGLAEEVRQAIQMLLNEIRMYNIHQGGAGTTSQAASTSGAAAATASYVPTVSGASLLPNLAVHEGIMQDRFTAEHVIISAPKNAKPTCELQLPSMKKLMSNSSAQPYFLRTLKIFMQVRDMYEAQNGLSTGGGVACG... | 65 |
H2LRA6 | 1.1.1.8 | ACT_SITE 206; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000114-1" | MMAAPKKVCVIGSGNWGSAIAKIVGANAAKYDTFDSTVKMWVFEETVNGRKLSEIINTDHENVKYLPGHKLPHNVLAVPDLVETVKEADILIFVVPHQFIAKVCDTIKDHIKKDAVGMSLIKGVDAGPEGLKLISEVIKGNLGITMTVLMGANIANEVADEKFCETTIGCKDKAYGPLLKKLMQTPNFRVTVVEESDVVEICGALKNIVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFARLFCTDCAVSPATFLESCGVADLITTCYGGRNRKIGEAFAKTGKSIEQLEKELLNGQKLQGPATASEVHQILKQKSMME... | 7 |
A0A0K9NJP0 | 3.4.21.89 | ACT_SITE 146; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 196; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MSTLSHLLNPPTHQNPSPNLSQGVSSAKPPSSKTAHFSSSSKPHLVPSLKTSTFAQKLIVQKPKSPKRRIKRCISFPEEEKGTKARCFLESGSGGADESKEEAKKGLFPDWLRICSDDVMSVLAAIAITLAFRSSMAEPKSIPSLSMYPTFNVGDRIVSDKVSYFFRKPCVNEIVIFKIPLVLMNAGYSDDDVLIKRIVAKEGDDVEVHDGKLIVNGAARDESFILEPPSYDMNLIHVPKDSVFVMGDNRNNSYDSHIWGPLPSKNIVGRSVFKYWPPKKRVL | 178 |
A8X073 | 3.1.1.4 | ACT_SITE 754; /note="Nucleophile"; /evidence="ECO:0000256|PROSITE-ProRule:PRU01161"; ACT_SITE 900; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU01161" | MAFTGLNWDHVKTTFWEANKMLDSMVTMIARSSGSRESSAESRSSGSSSDGALVAGPNGKLVMLKRKSTDEDEEDGAAMSKKPCLESDSASESSEAEDAKGSIRFLSSLTNVIMRPAQKATSTYSGADEWVPKEMEEIAEFPLESIDKYKKVHPNAEAPKKFMLVNGEFAVVASLEKLTEEQALRAQENSPHQHKHHDSREERLTKNELTDNEDQKKKKERDFRAKEEEEAKKGEKVLYHLAITLFNENKEKYVMSLFRSHKLADVVALCERCRENPELFRVFPKNVNIKEYLHLIFMELRDNMTWKSVHISSKIGLLEF... | 130 |
O66677 | 3.1.1.29 | ACT_SITE 21; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00083" | MDIKLVVGLGNPGKEYEKTRHNVGFMVIDELVKALRAKGPFEEALSHVYKARIGGKEVILAKPMTYMNNSGAAVYNLLEEYKLSPEQMIVVYDDLDLPLGHMRLRLKGSSGGHRGVESIIKYIGTQNFPRLRIGIGRPKKKEDVVKYVLSPFSPEEEKVISQVIKKAVRCLMRAIEISPEHAMEYCNRQDLI | 127 |
B4FHG3 | 1.11.1.7 | ACT_SITE 84; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MQSQASRMARSSGSRPVALVLLALCAAALSSATVTVNEPIANGLSWSFYDVSCPSVEGIVRWHVAEALRRDIGIAAGLIRIFFHDCFPQGCDASVLLSGSNSEQIEVPNQTLRPEALKLIDDIRAAVHAVCGPTVSCADITTLATRDAVVASGGPFFEVPLGRRDGLAPASSDLVGTLPAPFFDVPTLIESFKNRSLDKADLVALSGAHTVGRGHCVSFSDRLPPNADDGTMDPAFRQRLTAKCASDPSGNVVTQVLDVRTPNAFDNKYYFDLIAKQGLFKSDQGLINHPDTKRAATRFALNQAAFFDQFARSMVKMSQM... | 14 |
P28028 | 2.7.11.1 | ACT_SITE 561; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MAALSGGGGSSSGGGGGGGGGGGGGDGGGGAEQGQALFNGDMEPEAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLVFQTPTDASRNNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPVPQEEASFPETALPSGSSSAPPSDSTGPQILTSPSPS... | 99 |
A0A2C9UBY7 | 1.11.1.7 | ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MRTSFSLAFFFLITIALAYAIGVCYGGELRKDFYKDTCPEAEDIVKSIIWKRVASNSTLPAKFLRMHFHDCFVRGCDASVLLDSTTNNTAEKAAIPNLSLGGFEVIDEVKAQLEKKCPGVVSCADIVALAARDSVSFQFKKPIWEVLTGRRDGSISRASEALSNIPSPFFNFTLLKQSFANKSLTVHDLVVLSGGHTIGVGHCNFFSNRLYNFTGKGDADPSLNSTYASFLKTQCRSLADNTTIVPMDPSTPLSFDNNYYKILKLKEGLFQSDAALLTDKGSRNIVDELLDSGKFFTEFSQSMKRMGSIQVLTGTAGEIR... | 14 |
A0A2K1KQP6 | 3.4.21.92 | ACT_SITE 142; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 167; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086" | MRGAGRLWQASTAAAAELCCSLTRNRSGPSSPLAISSLSQFSRGYGLVPMVIEHTSRGERAYDIFSRLLKERIVCIHGPISDDTASLVVAQLLYLESEHPDKPIHLYINSPGGVVTAGLAIYDTMQYIRSPVSTLCVGQAASMGSLLLAAGQPGERRSLPNARVMIHQPSGGASGQASDIAIQAREILDMRARLSRLYVKHTGHTYEKIESSMERDHFMSPEEAKQFGLVDEVIERRPENLVADSVVLRR | 179 |
A0A1Y1HH65 | 3.4.21.89 | ACT_SITE 194; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 244; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MSSQVLARSGLNSSFLLHPAPSGLPTERPSPRNRHLAGYGAGQVSLPGLRCGYGPGKCTSFRRPVVSSPGRSRERFTFTCAQAKNSPPSDANPIATAVLNSKAPSENGSSSSQNSGAGGGGTHERKGVDEGDGDEGEFGSVPDLIPDAAKDVDSFLPEWARLNKDDVITVGVTFAVSLIFRTFIAEPRYIPSLSMFPTFDIGDRIITERISYYLHDPQVGDIVTFKAPPQLVARGYQDGEVFVKRVVATGGDVVEVHDGTLIVNGRQRNSETYIAEKPFYDLPPVRVPEDDVFVMGDNRNNSYDSHLWGPLPKKNIVGKY... | 178 |
A2DHT2 | 1.2.1.12 | ACT_SITE 172; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000149-1" | MVVKVAINGFGRIGRLVFRACRKLYPKDIQVVAIHDLGDIKTNVYLLKYDTAHRAFPEPVTVDEAKQEFTVGEGADKWVVKSIGGRLGPSQLPWKELGIDVVLESTGIFRTKAEKDAEGKIKKDGYDGHLVSGAKKVVLSVPSADEIECTLVLGVNDEDLKPETKCISNASCTTNCLGPVAKTLNNAFGIRNGFMTTVHSYTNDQVVADTMHKDLRRARAAGMNIIPTSTGAAIALPKVCHGLPPKSLDGFALRVPTITGSLVDLTVNVNAKVTKEEVNAALKKATEEGSLKGIMTYVTDPIVSSDIIGCQYSSIVDALS... | 22 |
I1KUG0 | 1.11.1.7 | ACT_SITE 63; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MALFVLSLLFFSFLMGMSSEGQLEVGFYSNTCPQVDSIVGAVVRDAVLSDPNMAAVLLRLHFHDCFVQGCDGSILIENGPQSERHAFGHQGVRGFEVIERAKTKLEGSCPGLVSCADIVALAARDAVVMANGPAYQVPTGRRDGLVSNLSLADDMPDVSDSIELLKTKFLNKGLSVKDLVLLSGAHTIGTTACFFMTRRLYNFFPSGEGSDPAISQNFLPQLKARCPKNGDVNVRLAIDAWSEQKFDINILKNIREGFAVLESDARLNDDIATKNIIDSYFSPFSPMFGPSFEADFVESIVKMGQIGVKTGFLGEVRRVC... | 14 |
H9GDX5 | 3.1.1.4 | ACT_SITE 301; /note="Nucleophile"; /evidence="ECO:0000256|PROSITE-ProRule:PRU01161"; ACT_SITE 431; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU01161" | INSNSGENECTPLHLACQKGDLASLQELVNECHARLDLTDKNGDTVFHYAVRGTNPKVIELLGRKSTVALDHLNEEGQKDVVISLLKVNAKCTNLGPLGYPIHTAMKNSQKKCAVALLDKEISQIQLVDSRHGATPLHWAKNAEMTRLLIEYGCDVNFLSATGDSALHIAVRRGRFDCVMVLLTHGAMTNCKGKDGNTPLHLAMQQDHLETIKALIVFGADMNIPNDVGETPGLLAARTSKEYQDYLHVSTLSSMVKKQDRLLSLDGGGVRGVVLIQFLIAIEKAAGRPVRELFDWVAGTSTGGILAIAAVHAKPMDHMR... | 130 |
A0A804LBH3 | 4.1.1.50 | ACT_SITE 61; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 75; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 234; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRS... | MAVSGFEGFEKRLELHFSGHDSLGLRRLRCDALAQVLDAVQCTVVSAVGNRYFDAYILSESSLFVYPYKMVLKTCGTTQLLRSVPCLLRHTAELGLRLRACRYSRGSFIFPRAQPFPHTSFAEEALYLEERLPPSLAFRKACVLPSSSSHSWHVYSASAADDDDRLAAGSWSTFTVEVCMTELDRSLARRFFRKKGDERSGDAVGADMTDLTEIGSINPRTLVCGFAFDPCGYSMNGLDRDSYSTIHVTPEEGHSYASFECTGRWAGGRAEVLDSLRKAIGVFRPGAVSVSFCMAPNVDENQVRSAVGDALEPLGLSCRS... | 196 |
A9T3U8 | 1.11.1.7 | ACT_SITE 70; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAISCRVWRLLLALCTLGSVGMESVNAQFFNNFYTTKGCDSAEAIVTQAVTEAFNQDPSVAPALIRMLFHDCFVEGCDGSLLLDPTPQNPNVEKLALPNLSVRGYEVIDAAKMQLEKTCPRTVSCADIVALAARDAVLLTGGQHFDMPTGRLDGMVSTADNANNNLVSTRSSATELTRKFLEQGLGQDDMITLSGAHTVGKTTCGQITSRLYNFPGTTNGVDPTLDFDYALHLQQLCPQNGNPNDPVPLDPVSPNTFDNMYYTNGVTGRVLFPSDNVLFADHQTQFASNLNSQNGQFWQMKFANALVRMASNKVKLGVPN... | 14 |
A7S4V3 | 1.1.1.37 | ACT_SITE 187; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1" | MAEPLRVCITGAAGQIAYSLLYSVAKGDVFGANQPIILHLLDITPMMGALGGVVLELQDCAIPLLHEVVATDDAEKAFTDIDVAILVGAMPRREGMERKDLLSANAKIFEAQGKALDKVAKKTCKILVVGNPANTNCLIAQRWAPSIPKENFSCLTRLDQNRGGSQIAGRLNLRVDQVKNVIIWGNHSATQYPDVNHGKVCVNGNWVAIRDAVKDDDYLNGEFISTVQKRGAAIIKARKLSSAMSAAKAICDHMRDWWFGTREGEWVSMGVVSDGSYGIEEGLVYSFPVQICDRTWKIVQGLSINDFSREKMNATATELK... | 5 |
A0A0P0V0Q2 | 3.1.1.11 | ACT_SITE 453; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MASTGALLLLLLFVLACGGNGGAAAAVFSGCSFESQEEAEAFEAALLQQACFNVTAFGGGGGGGGGEGGCVSRLDTARGGAGSGPVPVLRAAVRDTLGEAVGAVAAVAGLASLSNHAREEMAVRDCVELVGYSVDELGWALDAMADPDGGVAAAEEEDETEPETRRRRRRGARAEDDIHAWLSAAMGNQGTCLDGFHGTDSRLLRRVESAVTQLTQLVSNLLAMHKKLRDITPQHQHQHHHHPGNNNNKNGTADGAAAGGDDTGPSSDLPPWVTDVVNDVEEEVTATRGRGRSSSSGRKAMRVDVVVAQDGSGRWRTVSE... | 125 |
E1BCW3 | 2.7.1.11 | ACT_SITE 294; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03184" | MLRPPMGLSPPTCGVSPPSEVLPARKAPPICDAHRAPQPCGSPRSGPSCRPGSPAPGAPLNPAPPAPPAPSPPRPRARPRPPIGARRAGVAGGSRGGGAGGAQCLLSALQSAASGLFTMDGHDSPQTPKGSLRKFLEQLSGAGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIVEADWESVSSILQVGGTIIGSARCQDFRTREGRLKAACNLVQLGITSLCVIGGDGSLTGAHIFQTEWSGLLEELARDGKISTEQVQKHGHLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAI... | 84 |
Q1RML2 | 3.1.4.11 | ACT_SITE 170; /evidence="ECO:0000250|UniProtKB:P10688, ECO:0000255|PROSITE-ProRule:PRU00270"; ACT_SITE 215; /evidence="ECO:0000250|UniProtKB:P10688, ECO:0000255|PROSITE-ProRule:PRU00270" | MENKWFLLMVRDDFKGGKITLEKALKLLEKLDIQCNTIHVKYIFKDNDRLKQGRITIEEFRTIYRIITYREEIIEIFNTYSENRKILLEKNLVEFLMREQYTLDFNKSIASEIIQKYEPIEEVKQAHQMSFEGFRRYMDSSECLLFDNKCDHVYQDMTHPLTDYFISSSHNTYLISDQLWGPSDLWGYISALVKGCRCLEIDCWDGSQNEPVVYHGYTFTSKLLFKTVIQAINKYAFLASEYPVVLSLENHCSPSQQEVMADSLLATFGDALLSYTLDNFSDRLPSPEALKFKILVRNKKIGTLHETLERKGSDMHGKVE... | 153 |
Q7Q6E5 | 2.3.2.26 | ACT_SITE 1050; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MFGRTETNKDSFLVQTKAAREERAHERAQEERRDRSILLLQRTIRGWLARTKFRQRILNEFDELLPPVTNAGKPIELKPSLTVYGAASHFLLQWKAETSAPESAPHRERLERLCRYLVASLDSDSPKTSYIGVAFNKELSLAWIRHIKKLLYRCCTAIELLKPEVHSDSITLALYLHTLVAFTSINSWALLRNKALAGLKPGMTQLCANVMGDLVQKGFYLTLRNVLVKGTCRPVVNLKPISLTALVTLALRPLVSSGFSENLLSQFLVQILSVPGMMMQLEQYTPECLVSVQSHGTLEKTLDLLSGEQSTKFVVASLQN... | 65 |
A0A0K9NIX2 | 3.1.1.11 | ACT_SITE 415; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MTKKIILAGVSAMLLVAVVIGAVSGVMRSTNNFKISSQEKIKIHTVSRSIESICQITDYKEACLETLNAASPDNKTADPKTIVTASIKATFTEFSQAAGKSKEISTETMDNMNKVALSDCQELLEYAVEELQDAIESSDEGDAENIRRRSKDLKNWLSAVMSYQVVCIDGLTQPELKANMTNNLGKATELTKNALAIITEITRLLESMKGALNLKNDVMGAVAGGGAAGRKLLNSDVGGRYPEWFSASDRKLLRATNVAPMRVKPNAVVAKDGSGQYKTIQHAIDAIPKDNKGRYIIYVKAGVYRENVIISKKILNVFMY... | 125 |
P03007 | 2.7.7.7 | ACT_SITE 162; /note="Proton acceptor" | MSTAITRQIVLDTETTGMNQIGAHYEGHKIIEIGAVEVVNRRLTGNNFHVYLKPDRLVDPEAFGVHGIADEFLLDKPTFAEVADEFMDYIRGAELVIHNAAFDIGFMDYEFSLLKRDIPKTNTFCKVTDSLAVARKMFPGKRNSLDALCARYEIDNSKRTLHGALLDAQILAEVYLAMTGGQTSMAFAMEGETQQQQGEATIQRIVRQASKLRVVFATDEEIAAHEARLDLVQKKGGSCLWRA | 121 |
A2Q4B7 | 1.11.1.7 | ACT_SITE 60; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKQISIIIFFFILPLAFADLELGFYASSCRKAESIVKQVVQKRFNRDKSITAALLRMHFHDCFVRGCDASLLIDSTKNNISEKDTGANDSVRGYDLIDDVKEAIEAACPSTVSCADIVALATRDAVALSGGPKYNIPTGRRDGLIANRDDVDLPGPNIPIGALSQFFAAKGITTEEMVTLLGAHTVGVAHCGFFASRLSSVRGKPDPTMDPALDTKLVKLCKSNSDGAAFLDQNTSFTVDNEFYKQILLKRGIMQIDQQLALDKSTSTFVSNFASNGDKFVKSFATAMIKMGKVGVLVGNEGEIRKNCRVFNKRN | 14 |
Q869N2 | 2.7.11.1 | ACT_SITE 691; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P28523, ECO:0000255|PROSITE-ProRule:PRU00159" | MEQSKRVSMMREKFEAQSNEAESSPPPNRKPPPPNKRVQTNGTSSLNSSGSSFVSPSPSPSPSPQQPVKRPLPSPGVNKQAPPALPTQPRPQQQQPEIPVRPTTPTRTPPNLINSNGTSGGSGFSSSSGNSGYSSSNNNNSNSNSSINMNGNHSNGLNGGSSNPVPMRKVSSPINIANGTTPPPPPQPTPSQQPQQSPSSASHNNTQHNIPSPPPLPNNKPKKLAPTAVPAGLGSIIGGPKTPAISPGSTSPSLGSSNGNIPISTTSTPITPTPPISVPLATSPNNSHKDSISNSNSNNNNNNNNNNNNNSSNATTSPPS... | 99 |
K4AJW5 | 1.11.1.7 | ACT_SITE 64; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MDARLVTLLLLAAAASAPLASPQLDSAFYKTTCPDAEKVIFDVVQNRFKQDPGTAAGLLRLVFHDCFANGCDASILIDPLSNQASEKEAGPNISVRGYDVIEEIKTELEKKCPGVVSCADIVAASARDAVKLTGGPAYEVPMGRRDSLTSNREDADALPGPDIAVPKLIDEFSKQGFSLEEMIAMLAGGHSIGICRCFFIETDAAPIDPEYRKNISAACDGKDSGTVPMDSVSPNVFDGTYFALALAKKMPLTIDRLVGMDPKTEPVLKAMEAKPADFVPLFAKSMEKLSVLKVLTGKDGEIRKTCSEFNNPQASSDTSV... | 14 |
E3KZ81 | 3.5.1.2 | ACT_SITE 106; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1"; ACT_SITE 231; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1"; ACT_SITE 233; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1" | MDTSAGNLPEIPQLPEDAPLTIGVLALQGAFKEHLIHLRRIQSTRPLTAIAVRTSTELLQCQALIIPGGESTSISLIASRQIDPSNHSFLDWLKSFAKHRCVWGTCAGLILLSDQLVSEGTKTGGQEVLGGLPIKTTRNQWGRQTESFEQLIEIPFIKNPETPFPAIFIRAPMIHTILERAEPETGSKLQIIAHLPQDCVSRTPAQTGQSLGPDSHVVAVKFNHLFATSFHPELSPDTRLHQFWVNECVLKSL | 181 |
A0A9J7KN39 | 2.7.10.2 | ACT_SITE 988; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000636-1" | MAMGITNSRPSCHRHQRLSGLYVELYPTDSKEQRLNRQPLYYACEEEYTVEDLCFKAASTCDITPPYVSMFGLVKEDLATWLSPSTKVSAKKGEKVVLIFRLRFKFASLFEHRRPTRHGIDHHQNSTVLDENAMSYYFLQAREDFLSGRIKILPNNNKEKAIEQSLGLAVLDMLRISLEQNVPVDQIKKQYGYKDLLPPEMKQLLTRYNPFNRNRIKSKFNGFLQEWAEKEVENANRTALFMKEKYLKHMEQVEGRDYGWETFEGYDGRSKGTTVRELIRVSGDKGISWCNPPEGDPLPGMWQNFCDFQNLNDVSVQEIQ... | 98 |
Q9USN7 | 2.3.1.286 | ACT_SITE 138; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00236" | MVKNTVKHVDSSKHLEKVASLIKEGKVKKICVMVGAGISTAAGIPDFRSPETGIYNNLQRFNLPYAEAVFDLSYFRKNPRPFYELAHELMPEKYRPTYTHYFIRLLHDKRLLQKCYTQNIDTLERLAGVPDKALIEAHGSFQYSRCIECYEMAETEYVRACIMQKQVPKCNSCKGLIKPMIVFYGEGLPMRFFEHMEKDTKVCDMALVIGTSLLVHPFADLPEIVPNKCQRVLINREPAGDFGERKKDIMILGDCDSQVRALCKLLGWSDELEKLIDTSVETLTEEISLLSVDSTIEKNASEQKKDDNSVNPFTKIEEKK... | 58 |
T1FNN9 | 1.1.1.37 | ACT_SITE 190; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1" | MSAPKAPIRVVITGAAGQIAYSLLYPVAKGDVFGHDQPIVLVLLDIEVMLGVLKGVVMELVDCALPLLREIIPTADPNEAFEGADVAILVGAMPRKEGMERKDLLKANVKIFKVQGEALDKHAKKSVKVVVVGNPANTNAFICKKYAPSIAPENFTCLTRLDQSRAQSQVASRVHISAQDVHNIIIWGNHSSTQFPDVSHGCVLLNGQKVKIMDAVKDEAWLKGAFISTVQKRGAEVIAARKLSSALSAAKAICDHLHDWWFGTPEGRWVSMGVPSDGSYGVEKGLIFSFPVVIKPNKTYSIVTGLELDAFAKEKICATQ... | 5 |
A0A7M7NRU0 | 2.1.1.37 | ACT_SITE 1135; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MHVHPEGPVDDKGTLEDDSTVSSSFGPQNELFQENLKTSGEQASLSGSESTATNDRESEVSVNVQEHGLPWRHKRKSLCPRKILRKMEQEEASAGVPGNLIQEEWLTQAEDSASSTPTDERNVPESSQEQVRFSDPDKEILSECIETPPARLESPSVMESEEQSGQLNLLLDQDPMLAEGNFSCSSDQTMVPSSSQGAIEEAVSFPGLRFQSIQDFPSKNNDTRDSVEGNSASLLGEGFADVVNSSLIEETVQGDSLDNLLPGLNMLHVGRGVVEGNPLNEKGCRSQEKKDKTPKVKKHKHKSPHKNKRTSSARRLDMQH... | 47 |
H2LUR8 | 2.7.11.1 | ACT_SITE 155; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037993-1" | ILKESTDEEDPKLEFKAKYVELNPLGKGGCGSVFNGYRKSDKLVVAIKHIPNDYIYCTHFDESGRELSVEVAVMLKLQSGTSNSAGSKAPITLLDWYVLPHELILVLERPMPASDLHSYIERRGGSLKESEAKIILKQLVEAAIHLQDEKIFHRDIKLENILIEMCSGAPRVRIIDFGLSCFTETNSTHKTFCGTDRYVPPEWLSQYKYSAGPTTVWQLGIVLFECLHNKNFSTSSYMKRQIKMDNRLSKDCKDFLKQCCTRDPKERPSLEQIHLHPCTDFHWSNVHSLCSLAQTSLFCLLSFFSSGFLADILP | 99 |
A7RL71 | 3.2.1.35 | ACT_SITE 109; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038193-1" | FLGPALPNRTFISVWNAPTSACESRWGININLSSFDIVTNRGQTFYGESIVLLYSNIGLWPYINDKGDKINGGIPQLGNLSAHLDKALHDLLKVVPDPDFQGIGVIDWEAWRPVFDRNWDSKTIYKEASEALVKQQHPDWSSKAIETEARKQFEDTAKDYMLQTLQLAKKTRHKALWGYYGFPRCYNSKGPSDCSGVVKAENDQLSWMFESSSIIFPSIYLSPSLPRNRSSTFAKYNILEAFRLAVDEHGSNLPVFPYVRIVYAQTQIFLNKADMYSTIVQAAKLGTAGVIIWGASSDMENAEFCTELYNYIEGFVGPLI... | 166 |
O49839 | 2.7.11.1 | ACT_SITE 219; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MGNCLDSSAKVDNSNHSPHANSASSGSKVSSKTSRSTGPSGLSTTSYSTDSSFGPLPTLRTEGEILSSPNLKAFTFNELKNATKNFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQGHKEWLTEVNYLGQLSHPNLVLLVGYCAEGENRLLVYEFMPKGSLENHLFRRGAQPLTWAIRMKVAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKVIGTHGYAAPEYVATGRLTAKSDVYSFGVVLLELISGRRAMDNSNGGNEYSLVDWATPYLGDKRK... | 99 |
E3L3Z1 | 3.2.1.52 | ACT_SITE 421; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MMRLLLLLLLLLHPTTILTLWPKPQQLEQGQELIRLANNFTINFRPPKPTTISIDLASAISTTLNQLQTDNHQPLTTDRGRANHKRLTTTKLKQLSIELTPKPPAQQHHLTSTTTTTTGCDQEQQPIHSNIDLLLCHHPFTNSNYHQATTATQPQSQSLPSSTSNGPSIVAEMQYPLKARDEAYEIKIQATDHTQQDYTALLSANSALGLLRGLQTFSQLVYTLNPPPSTKETKTQKLSGGNEEQAVRYIQGPLHIKDQPAFPYRGLLLDTSRNYYSIDSLKKTIKTMSAAKLNILHWHIVDSQSWPLQIPFHPQLADNG... | 170 |
Q6C7U0 | 2.7.11.1 | ACT_SITE 150; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSSIKSYTIGNELGRGSFATVYKGEHVASGSPVAIKSVLRAKLNRKLLENLGSEISILKQMKHPHVVELLDFQETPTHFHLVMEYCSLGDLSFFLKKKKELSETLPLVASLLRRYPSNTRGLHEELVRHFVHQLSAALEFLRQKNLVHRDIKPQNLLLCPPSLSEMDAQNANLYGRWELPILKIADFGFARILPASALAETLCGSPLYMAPEILRYEKYNAKADLWSVGAVTYEMVVGKPPFKANNYVELLKTIEQSNDVIGFGREPPSEDMQDFVRCLLKKNPADRIGFKEYFEHPIIANKQVIGSGEELDRSQLDPRM... | 99 |
A0A1D6KM34 | 3.4.19.12 | ACT_SITE 98; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"; ACT_SITE 171; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1" | MSWAAIENDPGVFTELLQQMQLKGLQVSNQLSSLYESMFLLKVDELYSLDLDALNDLQPIYGLILLYKWRPPEKDEGPVIKDAIPNLFFANQIINKACATQAIVSVLLNSPGITLSDELKKLKEFAKDLPPELKGLAIVNCASIRMLNNSFARSEASEEQKPPSGDDDVYHFINYVPVDGVLYELDGLKEGPISLGKCPGGVGDAGWWLRLAQPVIKEHIDLFSQNEIRFSVMAILKNRKEMFTVEIKELQRKREGLLQQMGDPNASRHVEQSLAEVAAQIESVTEKIIMEEEKVKKWKAENLRRKHNYVPFLFNFLKIL... | 175 |
A0A2K3DWA6 | 4.1.1.17 | ACT_SITE 652; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | MTTSEVLSPPPPSQVASLAQPQFNVEALQAFSMPLVADVVNTENGDVASFARSSWHKESGKAGAFGLPTMLDMKAEALEQVQLDTWSAQPVDRGPAAAAPDPKLLRSWQYQATGKLATAQVLVDVKAEHIKAGGPMGMKQEAIKHILRHKPDDTFYVVDLANVQRMFKRSARERAARLALPDFSFATIRHVPPHIPTTPPPPRARHRVIYIHACIKLLCSAWSHPGLAISAKCTSTHTPHQAQAFSFMGKVLSGGGGGGGWHLETERGAWSGARRPSIVANSTTPVAPGNPLAYSRAILIGPVHCASVLSLSRVCTRMKP... | 195 |
A0A8V1A6N8 | 3.1.1.4 | ACT_SITE 70; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 119; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MKTLGVLFLLSAVAAIAAISPRALWEFRSMIKCTIPDSQPLLEFNDYGCFCGLGGSGTPVDELDRCCQAHDQCYSKAKLVCAASNDTPYTKTYKYSCENKAITCSSSNNECEMLVCNCDRTAAMCFSKAPYDPAHLHLDKKKYCSS | 130 |
P34517 | 1.1.1.8 | ACT_SITE 248; /note="Proton acceptor"; /evidence="ECO:0000250" | MSSSRIPQCENSSRLSLSSIFRYFGTTSTIATMSPKKVTIIGSGNWGSAIARIVGSTTKSFPDEFDPTVRMWVFEEIVNGEKLSEVINNRHENIKYLPGKVLPNNVVAVTDLVESCEGSNVLVFVVPHQFVKGICEKLVGKIPADTQAISLIKGISFDKTNQGVSTEKRGGLKLISEEIKEILKIEVSVLMGANLAPEVANDNFCEATIGCKRKAEDGPLLKKLFHTDNFRINVVEDAHTVELCGALKNVVACAAGFTDGLGYGDNTKAAVIRLGLMETTKFVEHYYPGSNLQTFFESCGIADLITTCYGGRNRKVCEAF... | 7 |
E9GJW4 | 2.7.10.1 | ACT_SITE 874; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MRSSLVALCLLLLVVDFSSTTVAATAEVQDGPVETVEAAVGHGLTLQCHLPDVANVSSAVTVRWERWATYHGAGPDANESKPRTGESLVVARRRRRRRHHHHHHRRRSRRLIHQGSALRFASISEADEGLYRCVGSSSSSSSFIDSTSVDEGGRGELDDPRSLILDHPDADNVTIVSAINDTEQQSGVVTSPSTDDGGDGGDDPRVVTTSTPSSTPVYGSFIYLRVQVAAVLTDYPESPVLIHPLRQQRRKQRLKCLAFGHPTPVIHWRINNNESLHQQVRLVEEADDEPIRRPQRGYIRSVVAIDWESSRQGDQENDQD... | 97 |
O24527 | 2.7.11.1 | ACT_SITE 371; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MDHNSPKSRRSRKPEPKPDIYSTFVVHSDSDSDQGRDRDKRKAKPEEDENVDLYATMVYKGDSDGEGEEDDDDDSMLPPLLKRLPKDFGGGASLDYDDDDGDESGDFGTMIVKTDRSSHSKKNSPYSSKPRMGVSPRRRARGGDEESSDEEDEEEDDDDDDGDYGTFVVKSKDKKGKKKDKEIDMTTMGRAVASMQKSNFGGKTRKLDPSSSSSKLHGEDNRKMQQQNSKMSTTSLPDSITREDPTTKYEFLNELGKGSYGSVYKARDLKTSEIVAVKVISLTEGEEGYEEIRGEIEMLQQCNHPNVVRYLGSYQGEDYL... | 99 |
Q6C7U8 | 2.7.11.22 | ACT_SITE 130; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MNTSSQFQQLEKLGEGTYATVYKGRNRTTGQLVALKEINLDSEEGTPSTAIREISLMKELKHENIVTLYDVIHTENKLNLVFEYMDKDLKKFMDTNGNKGALETKQVKWFMYQLLRGILFCHDNRVLHRDLKPQNLLINAKGQLKLADFGLARAFGIPVNTFSNEVVTLWYRAPDVLLGSRTYSTSIDIWSAGCIMAEMFTGRPLFPGSSNDDQLQHIFKLMGTPNESTWPNISSLPNYRSNFQVYAPQDLRVIIPQIDNVALDLLLSLLQLKPENRITARQSLEHPWFAEYHQ | 102 |
A0A9R0HUR0 | 3.1.1.11 | ACT_SITE 356; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAYYPIFLVIVTFLTFLVESYGDPPNLLSSWCNKTPYPKQCEYYLSHNQYSPPITGKSDFLKKMMQIALQNALKAHQSANSIEYSCKDEREKAALKDCLELYELSIQHLNQTMFTSSCTQVDAQTWLSSALTLFQTCQNGFSDLGVTKNVMPMLSNANVSCLISNALSINGPGPIGNNWDEPKDGFPDWVRPGDRKLLQSSSTRANLVVAQDGSGNYKTIGQAISGASGRKGGGRFVIYIKAGIYKENLEIGSNLKNIMFLGDGIGKTIITGSKSVGGGATTFRSATVAVVGSGFMAQGVTFRNTAGPSNHQAVALRSNS... | 125 |
D8T5T0 | 3.2.1.52 | ACT_SITE 260; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MDRYTALISGQRTLVQDLVINPPKFVLDKLRIDLFSYNQSLHIGTDESYHLQIPDPLDPKSAFLQANTVYGALRGLETFSQICRYNVEAKTIFLENCPWDIFDEPRFLYRGLLIDTARHYLPLNTIKTIIDSMAYAKLNVLHWHISDDESFPLEIPSFPKLWNGSYSNKQRYSLDHAKDLVKYAELRGISIMAEIDVPGHARSWGVGYPQLWPSQNCRTPLDVSKEFTFEVIDGIFFVHANLLDLRKAFPFELLHIGGDEIVGKAQSLFLNGLIFSKSNSIETRYLYDRLGKHNLTATQAYKFFVLEVQKLAMKHGYVPV... | 170 |
C0PKS1 | 1.11.1.7 | ACT_SITE 64; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MVRRTVLAALLVAAALAGGARAQLKEGFYDYSCPQAEKIVKDYVKAHIPHAPDVASTLLRTHFHDCFVRGCDASVLLNATGGSEAEKDAAPNLTLRGFGFIDRIKALLEKECPGVVSCADIVALAARDSVGVIVSAPDRVPPPPHASALPKPAKPIYKPVERACMQGGPFWSVPTGRRDGTVSIKQEALDQIPAPTMNFTQLLQSFQNKSLNLADLVWLSGAHTIGISQCNSFSERLYNFTGRGGPDDADPSLDPLYAAKLRLKCKTLTDNTTIVEMDPGSFRTFDLSYYRGVLKRRGLFQSDAALITDAASKADILSVI... | 14 |
F6H776 | 1.11.1.7 | ACT_SITE 415; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MEMVLPLVLVLVFSLTSQIEAELQVGFYRDKCRAESIVKDEVEKAFDRDRGIAPGLLRLHFHDCFVRGCDASILVDSTPMNVGEKDGPPNVNTLRGTEVIDSAKARLEAECKGVVSCADTLAFAARDAVEISNGFGWSVPAGRRDGRVSLASETLDIPAPFLNLDQLTQSFAKKGLTQEEMVTLSGAHTIGHAHCTSFSNRLYDFNASSSQDPSLNPLYAEDLKRQCPRGPQGTVDPNLVVDMNFSPAVMDSSYYTDVLHHRGLFTSDQALTTSQATARQVTTYAVNRLLWESEFAKAMVKMSQIEVLTGTDGEIRTNWN... | 14 |
Q94CU5 | 2.7.11.1 | ACT_SITE 133; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MDSRMDQYEVMEQIGRGAFGAAILVNHKTEKKKYVLKKIRLARQTERCRKSAHQEMALIARLQHPYIVEFKEAWVEKGCYVCIVTGYCEGGDMAELMKKANGTYFPEEKLLKWFAQLALAVDYLHSNFVLHRDLKCSNIFLTKDQDIRLGDFGLAKTLKADDLTSSVVGTPNYMCPELLADIPYGFKSDIWSLGCCMYEMAAHRPAFKAFDMAGLISKINRSSIGPLPPCYSPSMKSLIKSMLRKSPEHRPTASEILKSPYLQPYVNQYRPFADISHPIHSLEKPITSSRSSQKSMSGSQCSSISGSDIDSIQSSERNTS... | 99 |
A0A6I8N2V4 | 2.7.10.1 | ACT_SITE 778; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MHLGGLTALVTAVVWHGGASLLLEPSSPDLVVESGAAVTLRCPGNGSVEWFTGLGWGEPAPGWVPGFEGGSRTLSTARATYRDTGTYRCVDSESPDGKEASGHLYVKDPEHPWSVAARTIMVTAGNDALFPCRITDPALAARVSLQRDSGKNVRRGTRLTFDPRKGVTIHKVQLLDLNSYQCTAIIGGEKKPSPTIELKVKEAITEPPLLWLEPRESVRIRGEPFSVTCEASNPNVDFDLTLQHQQEQVPGNLIADFALTRGYSKNISHRIARVAEEDGGTYSCNSTNVKGSSVASMVLRVVDRAYVNLSSEQSRRLEVD... | 97 |
P33363 | 3.2.1.21 | ACT_SITE 287; /evidence="ECO:0000250" | MKWLCSVGIAVSLALQPALADDLFGNHPLTPEARDAFVTELLKKMTVDEKIGQLRLISVGPDNPKEAIREMIKDGQVGAIFNTVTRQDIRAMQDQVMELSRLKIPLFFAYDVLHGQRTVFPISLGLASSFNLDAVKTVGRVSAYEAADDGLNMTWAPMVDVSRDPRWGRASEGFGEDTYLTSTMGKTMVEAMQGKSPADRYSVMTSVKHFAAYGAVEGGKEYNTVDMSPQRLFNDYMPPYKAGLDAGSGAVMVALNSLNGTPATSDSWLLKDVLRDQWGFKGITVSDHGAIKELIKHGTAADPEDAVRVALKSGINMSMS... | 161 |
G1KHD8 | 3.4.19.12 | ACT_SITE 36; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 139; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 154; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331" | MSCVPWKGDKTKSEAPETPQQTPVRIYHEKQRRELCALHALNNVFQDGNAFTRDTLQEIFQRLSPNTMVTPHKKSMLGNGNYDVNVIMAALQTKGYEAVWWDKRRDVNVIALSNVMGFIMNLPSSLCWGPLKLPLKRQHWICVREVGGTYYNLDSKLKVPEWIGGETELRKFLRHQLRGKNCELLLVVPEEKPPHSSGPHIPMTKTSWQNLYTSTHFSQAEHQACSSASNLKPFFSNVLKYIYTVSAGKTILYAV | 175 |
P00536 | 2.7.11.1 | ACT_SITE 198; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MPSPLSLCRYLPRELSPSVDSRSCSIPLVAPRKAGKLFLGTTPPRAPGLPRRLAWFSIDWEQVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTKDLRASQRSFWAELNIARLRHDNIVRVVAASTRTPEDSNSLGTIIMEFGGNVTLHQVIYGATRSPEPLSCREQLSLGKCLKYSLDVVNGLLFLHSQSILHLDLKPANILISEQDVCKISDFGCSQKLQDLRCRQASPHHIGGTYTHQAPEILKGEIATPKADIYSFGITLWQMTTREVPYSGEPQYVQYAVVAYNLRPSLAGAVFTASLTGKTLQNIIQSCWEA... | 99 |
Q9HDW7 | 7.2.2.10 | ACT_SITE 545; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000250|UniProtKB:P04191" | MPTYNDDDDSSRPPSVHSERNQKPSSSQFLGVPSSNYNQRENSSRSGSSTISREPSSSGTMYPMASRDSMKESYDKNKGTPPDYTSYVSHSDAEPEQASSKSSTSIEDLLHTEYDDAPFAFSIPLLQRLQDPKNTSLLHAIHGLKGLCKGLKVDPSTGISTHEPHYADKLQMSDILNDDSNPKLVVHLDRIRSQDNNPEAKVSHDSDRVKYYGKNVLPEHDSKGLIRLMLEAFKDKVLILLSIAAVVSLALGLYQTFGQPPTLDPITGKPEPRVEWVEGVAIMAAIVIVVTVGGVNDWQKELQFKKLNAKVSNFDVQVLR... | 258 |
A0A8I6Y3A4 | 2.3.2.26 | ACT_SITE 830; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MYRRHAKRRREAPDHALPASSKAPVMTAAHSAASSSSAAGGAAAGASSSSSSSSSPFYAPPPPPPRRLHFFVRATDSKTIAIHAAADDTVAAVLSHLADCGYGRDLRLLYAGRQLQPEATVASLGLAPDSTLHLAARLRSTPHPKAWQLASHIAATAASGVAGADTAHSLDDLVKEFIACCDPGNQQNRNDRKAKGDAGSTEHQAQEYLDIFLQSGAAIALVRLYLSDFTFSRSFAERAIRCFLSTDPATLPPNVMLVTAPVLLEFCRLLALTSGNKDSLYKSCRYTLASVLCVPLPVVPASKSPTKAIEQVLPFAREIV... | 65 |
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