In Vitro and In Vivo Inhibition of Human Fanconi Anemia Head and Neck Squamous Carcinoma by a Novel Nutrient Mixture
Dr. Rath Research Institute
HomeContact Us
Dr. RathBiographyVisionSpeechesConceptsDiscoveriesCellular MedicineHeart DiseaseCancerInfectionsDiabetesResearchVisit the LabResearchersDr. Niedzwiecki's BioOther researchersProjectsHeart DiseaseArrhythmiaHeart FailureHypertensionCholesterolCancerWomen cancersMen cancersBlood cancerSkin cancerBone cancerInfectious DiseasesHIV/AIDSTuberculosisHuman InfluenzaMicronutrients and ImmunityToxicologyInflammationArthritisOther ProjectsPublicationsLeading PublicationsCancerProstate CancerTesticular CancerBreast CancerCervical CancerOvarian CancerColon CancerBone CancerPancreatic CancerFibrosarcomaKidney and Bladder CancersSkin CancerLung CancerBlood CancerLeukemiaOther CancersMetastasisAngiogenesisHeart DiseaseOther ResearchInflammationInfectious DiseaseToxicologyBone HealthOtherPresentationsHeart DiseaseCancerOther ResearchClinical StudiesArrhythmiaArthritisAsthmaAtherosclerosisCholesterolDiabetesHeart DiseaseHeart FailureHigh Blood PressurePeriodontosisTinnitusEducationPhytobiology and Cellular MedicineOnline SeminarHealth ReviewsEducation materialsLibraryHealth FreedomNational (U.S.)InternationalTestimonialsIndividual TestimonialsPhysicians SpeakNewsHealth NewsBusiness with DiseaseGlobal IssuesContact Us
Skip navigation
LEARN MORE ABOUT
Dr. Rath's Healthcare VisionMeet Our Research StaffResearch PublicationsBusiness With DiseaseWorld Health AlphabetizationVitamin FreedomOnline Seminar
In Vitro and In Vivo Inhibition of Human Fanconi Anemia Head and Neck Squamous Carcinoma by a Novel Nutrient Mixture
M.W. Roomi, N.W. Roomi, M. Rath and A. NiedzwieckiDr. Rath Research Institute, Cancer Division, Santa Clara, CA 95050
Presented at: 23rd Annual Fanconi Anemia Research Fund Scientific Symposium, Barcelona, Spain, October 20-23, 2011.
Published in: Proceedings of the 23rd Annual Fanconi Anemia Research Fund Scientific Symposium, page 139.
Abstract
Objective: Fanconi Anemia (FA), an autosomal recessive disease associated with chromosomal instability, is characterized by progressive bone marrow failure, birth defects and high propensity to develop malignancies.  Head and neck squamous cell carcinoma (HNSCC) and acute myeloid leukemia are the major causes of mortality and morbidity in FA patients. The objective of this study was to investigate the antineoplastic activity of NM, a novel antineoplastic nutrient mixture (containing lysine, proline, ascorbic acid and green tea extract) that demonstrates a broad spectrum of antitumor activity against a number of human cancer cell lines, on human FAHNSCC in vitro and in vivo.
Methods and Materials: Human FAHNSCC cell line OHSU-974 (Fanconi Anemia Research Fund, Oregon Health & Science University, Portland, Oregon, USA) was cultured in RPMI medium supplemented with 20% FBS and antibiotics. At near confluence, cells were treated in triplicate with different concentrations of NM: 0, 50, 100, 250, 500 and 1000 μg/ml. Cells were also treated with PMA to induce MMP-9 activity. Cell proliferation was detected by MTT assay, secretion of MMPs by gelatinase zymography, invasion through Matrigel and morphology by H&E staining. In vivo, athymic male nude mice (n=12) were inoculated with 3x106 OHSU-974 cells subcutaneously and randomly divided into two groups: group A was fed a regular diet and group B a regular diet supplemented with 1% NM. Four weeks later, the mice were sacrificed and their tumors were excised, weighed and processed for histology.
Results: NM inhibited the growth of OHSU-974 tumor by 48% and tumor burden by 50%. At lower concentrations, NM demonstrated no effect on proliferation, but at 1000 μg/ml showed 40% toxicity. Zymography revealed MMP-2 and PMA-induced MMP-9 secretion. NM suppressed secretion of both MMPs in a dose-dependent manner, with virtual inhibition at 500 μg/ml. NM inhibited OHSU-974 invasion through Matrigel in a dose-dependent fashion with total block at 1000 μg/ml. H&E staining showed no morphological changes below 500 μg/ml.
Conclusions:The results suggest that NM has potential therapeutic use in the treatment of human FA HNSCC.
Comment
Current treatment methods for Fanconi Anemia-associated cancers are generally ineffective. Thus, there is a need for development of effective therapeutic agents for these cancers with minimal toxicity. Our studies demonstrated that NM significantly inhibited the growth and tumor burden of FA HNSCC cell line OHSU-974 in vivo. In addition, invasive parameters, such as OHSU-974 cell line MMP-2 and -9 secretion and invasion were significantly inhibited by NM in vitro. These findings suggest potential of NM


Page 2 : November 2008 : Archives : Cricket Blog : Latest news, Reviews, Previews, and information on cricket, tests, one day internationals, cricket world cup, netwest cricket cup, ICC cricket cup, ashes cricket series, county cricket, domestic cricket, ranji cricket, BCCI, ICC, SLC, WICB, Championship..
slideshows
gallery //
In Focus
Players
Snapped
Match Reviews
Tests
ODIs
Twenty20
More >>
Schedule
Archives
Want to dig the Cricket Blog Archives? You can find what you're looking for below using the search box or monthly archive or look through a list of our most recent 25 articles. Alternatively, you can use the built in search box on the right to find what you're looking for.
Next
Previous
No Romantic Angle behind Ishant's Hair Cut
Sreelata Yellamrazu | Nov 26 2008
by Veena Gabriel
Failed to recognise the fast bowler at the pavilion end. Turned out it was was no other than India's super fast bowler Ishant Sharma.
Recognised by his lion mane, Ishant was ragged by his team mates before the match...
Read More
Next
Previous
After
Victory, Expect the Rotation Ring
Sreelata Yellamrazu | Nov 25 2008
Now comes the circus part of the series. With India having pocketed the series, the only fascinating element about the sport, apart from the remote possibility that England can get their act together, would be seeing how Dhoni and his selection.
Read More
Next
Previous
McGrath Return: Boon Not for Australia
Sreelata Yellamrazu | Nov 25 2008
The kind of days Australia is facing, even with the win against New Zealand, they could use a stinging bowler like Glen McGrath. But that not seem like in the offing though he is coming back to the cricket field to play. But not for Australia...
Read More
Next
Previous
Home Turf-Experimentation
Sreelata Yellamrazu | Nov 25 2008
by Kartik Kannan
India seem to finally seem to rise from the phoenix, whenever they play at home. Their home ODI
record since the second half of 2005 has been enviable. One of the things with playing on home turf is that the youngsters start.
Read More
Next
Previous
Andrew Symonds- The Man Trouble Comes Looking For
Sreelata Yellamrazu | Nov 25 2008
by Veena Gabriel
No, strangely it was not the hot headed cricketer's fault, at least not this time.
As per the reports coming in Symonds was accused of instigating a fight with a guest at Brisbane hotel. It seems that Andrew had gone..
Read More
Next
Previous
India wins the Fourth match and the ODI series
Sreelata Yellamrazu | Nov 24 2008
by Rupesh UK
The fourth match of the Hero Honda cup was played at the Chinnaswamy Stadium in Bangalore. India who leads the series 3-0 would try to win the match and pocket the seven match One Day International (ODI) series. England had to win the.
Read More
Next
Previous
Ponting: I am not talking to Border and Ian Chappell
Sreelata Yellamrazu | Nov 24 2008
by Veena Gabriel
The Australian Captain is
very angry, obviously after getting defeated by India and losing the Border-Gavaskar trophy.
He has to face flak from every side,The former Australian Captains Border and Chappell
are no..
Read More
Next
Previous
Australia thrash New Zealand
Sreelata Yellamrazu | Nov 24 2008
by Shreyas S. Bhide
In a low scoring encounter that lasted 4 days, Australia thrashed New Zealand by 149 runs at the Gabba, Brisbane. Mitchell Johnson claimed his maiden five-wicket haul as Australia staged an impressive comeback from their...
Read More
Next
Previous
Dhoni -
An Ideal Icon
Sreelata Yellamrazu | Nov 24 2008
by Veena Gabriel
A good cricketer,a better captain and above all a fabulous human being,yes that is our Mahi, who gives his best to cricket,playing his best strokes every time he is on the field, and winning matches for us
He is a better...
Read More
Next
Previous
India on Top; England Easy Pickings
Sreelata Yellamrazu | Nov 23 2008
by Rupesh UK
After its emphatic series victory against Australia in the Border- Gavaskar trophy, the Indian cricket team faced a new challenge against the visiting English team, a lengthy seven match One Day International (ODI) series. Although...
Read More
Prev
1
2
3
4
5
6
7
8
9
10
Next
Featured Stories
Kevin Pietersen's Eden Gardens Dream Comes True Despite Broken Finger
Cricketers in India usually grow up dreaming of playing at Lord's one day. And a few Indian cricketers may indeed made their Lord's appearance something to cherish. However, Kevin Pietersen had a unique dream that he was happy to accomplish even if the st
Imran Khan Can Still Pull in the Crowds ( Picture)
Who said Imran Khan is past his prime? In a political rally for his party, Tehreek e Insaf, Imran Khan, the former Pakistan captain turned politician, reportedly drew in crowds of over 100000 in bid to fight corruption in Pakistan. How's that for a pictur
Formula One Overtakes Cricket As No.1 Sports Passion in India. Likely?
The first ever Indian Formula One Grand Prix drew a lot of reaction from those involved in the racing and those outside of it. One of those was the ambition that Formula One would pip cricket passions in the country. Is that possible? And would it be good
Kevin Pietersen Hears from ICC After On Field Argument with Umpire during T20 v India
Kevin Pietersen played a terrific knock to ensure that England did not return home disappointed from India, but not before catching the ire of the umpires and subsequently the ICC as well.England all rounder, Kevin Pietersen, batted in the one off Twenty2
FEATUREDIN PAST
CONNECT WITH US
ADVERTISE WITH US
Advertise with usContact UsArchives
Crick Blog© 2010 Instamedia Pvt. Ltd.All rights reserved
ON THE NEXT PAGE
Greg Chappell's Praise and Appraisal of Sachin...
SA's Test Squad v Australia Includes Jacques Rudolph...
New ICC Twenty20 Rankings Launch Sees England at Top...
Kevin Pietersen's Injury Agony Sees Him Miss Final ODI...
Nathan Bracken Sues Cricket Australia for Injuries;...
Shane Watson Should Not Bat Down the Order for...
Dale Steyn Hopes Gary Kirsten’s Rotation and Rest...
Dada Switches from Cricket to Formula One; Has India


Last-Modified: Mon, 27 Feb 2012 19:41:42 GMT
Accept-Ranges: bytes
ETag: "2345f6d487f5cc1:daf"
Server: Microsoft-IIS/6.0
X-Powered-By: ASP.NET
Date: Thu, 01 Mar 2012 13:50:46 GMT
Connection: close
Home of the Concordia University, St. Paul Golden Bears
Official site of Concordia University, St. Paul Athletics
Home
Men's Sports
Baseball
Basketball
Cross Country
Football
Golf
Track & Field
Women's Sports
Basketball
Cross Country
Golf
Soccer
Softball
Track & Field
Volleyball
Inside Athletics
Athletes of the Week
Athletics Alumni
Bear Wear - NEW!
Cheer Team
C-Club
Department News
Division II History
Facilities
Fundraising Events
Hall of Fame
Marketing Interns
Recruit Information
Sea Foam Stadium
Sports Medicine
Staff Directory
Student Rewards
Visitor's Guide
Northern Sun
NSIC Home
Augustana
Bemidji State
Univ. of Mary
Minn., Crookston
Minn. Duluth
Minnesota State
MSU Moorhead
Northern State
St. Cloud State
SW Minnesota St.
Upper Iowa
Wayne State
Winona State
NCAA
Athlete Handbook
I Chose Division II
NCAA.com
NCAA.org
NCAA Blog
Golden Bears Face Road Tests This Weekend
Dec. 10– ST. PAUL, Minn. - The Golden Bear women's basketball team has jumped out to a great start this season, 6-0 overall and 2-0 in NSIC play and can build a true name for themselves this weekend.  They head out on the road for games against Minnesota, Crookston (3-4, 1-1 NSIC) and an undefeated MSU Moorhead squad this Friday and Saturday, with tip-off times of 6:00 pm both nights.  This is the last NSIC action of the 2009 calendar year, with three non-conference games scheduled over the holidays.  VIEW COMPLETE RELEASE  -  WATCH LIVE  -  LIVE STATS
Concordia will have to be focused and prepared for both games this weekend.  Minnesota, Crookston is a different team than they have been in the past, taking a non-conference win from Winona State, a league win over Bemidji State and forcing Minnesota Duluth into an overtime period.  They have been able to put up plenty of points, but the Golden Bears hope their fast offense will overpower UMC's defense.
MSU Moorhead is neck-and-neck with Concordia in receiving points for the national poll but not yet taking in a top-25 ranking.  Both squads will aim to keep their season undefeated on Saturday night.  The Dragons look much different than the Golden Bears, with the majority of their scoring and defense coming from post players.  CU and MSUM are the NSIC's two leading points-scorers, the Golden Bears using speed and guards to score and the Dragons bumping and forcing their hand down low with their bigs.  MSUM leads the NSIC in rebounding and has used shot blocking to stifle opponent shooting, limiting them to 30.1%.  Concordia hopes to attack MSUM before they have a chance to use their posts, expecting a full court press and on-ball pressure to take the advantage in the game.
Guard Jineen Williams (Jr., Racine, Wis.) is the top averaging scorer for Concordia so far this season.  She averaged 18.0 points and 4.5 rebounds per game while shooting 50% from the field last weekend and has a team high 16.7 ppg this year.  Guard Maurika Hickman (Jr., Minneapolis, Minn.) has also had a strong few weeks, now averaging 13.8 ppg.  Jamie Jones (Sr., Mounds View, Minn.), also a guard, is the team's third-leading scorer with 12.3 ppg.  Jones


Cache-Control: max-age=1200
X-Cache: MISS from parent1.peak.zope.net
X-Cache: MISS from cache4.peak.zope.net
Via: 1.0 parent1.peak.zope.net:8500 (squid/2.7.STABLE9), 1.0 cache4.peak.zope.net:8500 (squid)
Vary: Accept-Encoding
Connection: close
Schools awarded technology grants » DerryNews.com, Derry, New Hampshire
DerryNews.com, derry, New Hampshire
January 21, 2010
Schools awarded technology grants
Chester among 22 schools to earn stimulus funding
CHESTER — Chester Academy is among 22 school districts have been awarded grants of approximately $145,000 each from the federal Enhancing Education Through Technology Program (NCLB Title II-D) as part of the American Recovery and Reinvestment Act (ARRA) of 2009.
A total of $3.2 million in federal funds has been allocated to New Hampshire schools to develop technology rich learning environments as part of the state's 21st Century Classrooms Initiative.
These classrooms will be well equipped with computer hardware, software, electronic presentation systems, and rich digital and online curricular resources.
Students in these classrooms will be highly engaged in interactive learning and higher level thinking skills, whether learning math,
science, reading, or history. The use of digital cameras, interactive white boards, robust courseware, digital content, computers, and mobile learning tools will provide students with opportunities to collaborate and connect to rich and relevant content. Investment in core components for technology, collaborative planning, enthusiastic and well-informed leadership, intensive professional development, and IT support are some of the key elements necessary to transform these schools into 21st century classrooms.
In addition to Chester, other districts receiving the ARRA funding include: Alton, Bartlett, SAU 6 (including Claremont & Unity), Laconia, Lafayette Regional, Manchester, Milton, Nashua, Oyster River, SAU 53, (including Allenstown, Deerfield, Epsom, Pembroke), Pittsfield, Portsmouth, Profile, Raymond, Somersworth


Obituaries
Higby Mortuary
Lucile Parker
Lucile Parker, age 94, of Aurora, died Saturday, August 28, 2004, at Memorial Community Care.
Funeral Services will be held 1:00 P.M. Thursday, September 2nd at the Higby-McQuiston Chapel. Rev. James Keyser will officiate.
A Private family burial will follow the service at the Aurora Cemetery.
There will be no visitation.
Memorials may be made to the Memorial Hospital Foundation, 1423 Seventh Street, Aurora, NE
68818.
Condolences may be e-mailed to the family through the mortuary website at higbymortuary.com.
OBITUARY:	LUCILE PARKER
Lucile Margaret Parker, the daughter of Frank L. and Mabel (Cavanaugh) Gleich, was born in Platte, South Dakota on July 7, 1910 and died in Aurora, Nebraska on August 28, 2004, at the age of 94.
She was raised in Gayville and Yankton, South Dakota, where she graduated from high school.
Lucile was united in marriage to Gerald L. (Jerry) Parker on August 17, 1930 at Yankton, South Dakota.
Jerry worked for the J.C. Penney Company, in Yankton, Sioux Falls, and Huron, South Dakota.
He became manager of the Penney's store in Superior, Nebraska and Lucile worked for the Superior Express newspaper.
They lived in Superior for 21 years, where they raised their family.
In 1965, they moved to Aurora and opened "Parkers of Aurora".
In 1973, they retired and moved to Estes Park, Colorado, where they lived for 18 years.
In 1991, they returned to Aurora.
Jerry passed away on October 23, 1997.
Lucile was a member of Aurora Presbyterian United Church of Christ, where over the years she served on many committees.
She was a member of the PEO and DAR, the Memorial Hospital Auxiliary and the Women's Club, both in Superior and Aurora.
She was preceded in death by her parents, her husband, a sister, Marjorie Gordon and a great-granddaughter, Abby McMinn.
Those left to cherish her memory are her three children, Joanne Howard of Edwards, CO and Bonita Springs, FL, David Parker of Lincoln, NE and Dr. Richard Parker of Denver, CO; 9 grandchildren; 21 great-grandchildren and 5 great great-grandchildren.
She is also survived by a sister, Helen Kost of Aurora and a brother, Robert Gleich of Veneta, OR


Last-Modified: Thu, 15 Sep 2011 19:46:16 GMT
Accept-Ranges: bytes
ETag: "dee6e22e073cc1:dde07"
Server: Microsoft-IIS/6.0
MicrosoftOfficeWebServer: 5.0_Pub
X-Powered-By: ASP.NET
Date: Thu, 01 Mar 2012 17:03:39 GMT
Connection: close
Future Babies Private Ultrasound Scans for pregnant women in Reading, Berkshire - Dating, Sexing, Reassurance, 3D, 4D Scans.
Home
Your
Scan
Early Dating
Scan
Dating
Scan
Reassurance
Scan
Gender
Scan
Growth
Scan
Presentation
Scan
3D/4D
Scan
Personalised
Cover
Soundtrack Options
Keepsakes
Galleries
Testimonials
Contact
Us
About
Future Babies
Job
Opportunities
Contact
Us
Future Babies
Ltd
48 London Street
Reading
Berkshire
RG1 4SQ
Tel: 0118 958 5050
email: info at future-babies. co. uk
The Future Babies Studio is in the centre of Reading, just 2 minutes from the Oracle Shopping Centre. There is ample parking to choose from or Reading train station is only a 10 minute walk away.
The studio is open Monday - Saturday, from 9am to 5pm
Directions...
Below you can find directions to the Future
Babies studio by car, by foot from the closest car parks and by
foot from Reading train station.
We send out a copy of all directions by post
or email with your booking confirmation.
Future Babies is situated in the heart of
Reading town centre. We are just a 2 minute walk from The Oracle shopping Centre car park and the Queens Road car park. Reading train
station is only a 5 minute taxi ride or a 10 minute walk away.
Directions From the A329 (J10 M4)
Come off the M4 motorway at Junction 10
onto the A329 (M) towards Reading
Continue along the A329 and follow signs
for Reading and Suttons Business Park .
Come off the A329 onto the roundabout
signposted Reading and Suttons Business Park .
At the roundabout take the 1st exit for
Reading East and A4. This will take you under a railway bridge.
Continue along the A4 onto the one way
system passing The Granby and the Up in Arms public houses. This
takes you onto London Road .
Continue along London Road , past the
Royal Berkshire Hospital , following signs for the Oracle Shopping
Centre.
Follow the one way system to the right
and onto Southampton Street .
At the Oracle roundabout take the 3rd
exit to park in one of the multi storey car parks.
For the Oracle Car park, you will need
to be in the left hand lane and follow the signs.
For Queens Road car park, continue straight
for 500 metres and it is to the left.
Alternatively, you can take the 4th exit
at the Oracle roundabout, sign posted Aldershot A327 and follow
the one way system onto London Street . Future Babies is the 3rd
shop on the right and there is ample parking on London Street
.
Back to top
Directions from the A33 (J11 M4)
Come off the M4 motorway at junction 11
onto the A33 towards Reading .
Pass the Madejski Stadium (home of Reading football club) and B & Q Warehouse on your left.
Continue straight over all roundabouts
following signs to the Town Centre.
Pass Peter Green on your left and Lock
‘n’ Store on your right.
Move into the right hand lane and follow
signs for The Oracle shopping centre.
At the Oracle roundabout take the 2nd
exit to park in one of the multi storey car parks.
For the Oracle Car park, you will need
to be in the left hand lane and follow the signs.
For Queens Road car park, continue straight
for 500 metres and it is to the left.
Alternatively, you can take the 3rd exit
at the Oracle roundabout, sign posted Aldershot A327 and follow
the one way system onto London Street . Future Babies is the 3rd
shop on the right and there is ample parking on London Street.
Back to top
Directions from the A4 (J12 M4)
Come off the M4 motorway at junction 12
onto the A4 towards Reading .
Pass the Reg Vardy Ford garage on your
right.
Continue along the A4 following signs
for the Oracle.
Go over the railway bridge and continue
straight along the A4. Do not leave the A4.
At the roundabout with Thames Valley Police
station take the 3rd exit onto the M4 East / A329 sign posted
The Oracle shopping centre.
Stay in the left hand lane and continue
to the Oracle roundabout.
To park in one of the Multi storey car
parks take the 2nd exit.
For the Oracle Car park, you will need
to be in the left hand lane and follow the signs.
For Queens Road car park, continue straight
for 500 metres and it is to the left.
Alternatively, you can take the 3rd exit
at the Oracle roundabout, sign posted Aldershot A327 and follow
the one way system onto London Street . Future Babies is the 3rd
shop on the right and there is ample parking on London Street
.
Directions by foot from the Oracle Car park
When you come out of
the car park you will see the river in front of you with shops
on either side.
Walk to your right
and continue to the edge of the shopping complex. You will pass
Pizza Hut, Nandos, and the Cinema, all on your right.
At the edge of the
shopping complex follow the pavement round the corner to the
right. You will then see 3 main roads in front of you.
Cross over all 3 of
the roads using the crossings to your right
You are now on London
Street and the Future Babies studio is the 3rd shop on the right.
Directions by foot from the Queens Road car park
As you
come out of the car park you will see the main road in front
of you.
Turn right
and walk to the end of the street. (about a minute walk)
At the
end of the road you will be able to see London Street on your
left. The Future Babies studio is the 3rd shop up on the right
hand side of the street.
Use the
crossings to your left and then cross over to the right side
of the road once on London street
Directions by foot from Reading Train Station
Future Babies is only a 10 minute
walk from the train station.
• Leave the train station via the
side entrance. This is to the right of Marks and Spencers.
• Cross over the road and walk down
Blagrave Street
• Bear left and pass the Town Hall
on your left. Cross over to walk past the Post Office and continue
down High Street.
• At the bottom of High Street you
need to cross over onto Duke Street


The Medical Leader » Eastern KY counties developing multi-county trail system
The Medical Leader
Home
Home
> Community News, Uncategorized		 > Eastern KY counties developing multi-county trail system
Eastern KY counties developing multi-county trail system
November 18th, 2011
ECO ECONOMY: Eastern Kentucky communities are joining forces to develop a trail system through several counties. Neighboring West Virginia communities are already seeing benefits from development of the Hatfield and McCoy Trail System, which attracts thousands of tourists and generates millions in revenue each year. This photo was taken during the 2011 Trailfest in Gilbert, W.Va.
PIKEVILLE – Counties throughout eastern Kentucky plan to boost the economy by developing and promoting adventure tourism activities.
Big Sandy Area Development Director Sandy Runyon, who has worked with local leaders to establish trail systems in eastern Kentucky for a number of years, reports that officials in Breathitt, Clay, Knott, Leslie, Bell, Letcher, Perry, Owsley and Harlan counties have worked together for quite some time to develop a trail system that would attract ATV riders, horse enthusiasts, hikers and others into eastern Kentucky.
Runyon explained that those counties have entered into an interlocal agreement regarding the trail system, with the understanding that each county is responsible for trail development and maintenance in their counties. Officials in these counties also agree that counties would assist each other with maintenance or other issues on neighboring properties, with the understanding that counties won't be billed for that service and with goal of eventually connecting all trails together in one large system.
The Pike County Fiscal Court is the first of several Big Sandy area counties to become a part of the initiative by passing a resolution to join the multi-county effort during a Nov. 1 meeting. Although Pike county officials talked about developing a trail system to mimic the successful Hatfield-McCoy ATV Trail system in West Virginia, Runyon believes the interlocal agreement, once it is finalized, will encompass all types of trails and trail-based activities.
The first step is for Fiscal Courts in those counties to pass a resolution stating the county's intent on participating. Thereafter, county attorneys will hash out a finalized interlocal agreement that suits the needs of all counties. The Big Sandy ADD is currently preparing resolutions for other Big Sandy counties.
“I'm not sure how many counties will sign on,” Runyon said. “But we know that Pike, Floyd, Magoffin and Martin counties are interested and we expect that Johnson County will also be interested. Our goal is to have any kind of agreement they enter into to include all trails.”
Once the interlocal agreement between the counties is finalized, Runyon said it is likely that individual counties will be responsible for obtaining land-use permits from residents, which could be a “huge endeavor” in counties like Pike County, where officials have identified 200 property owners along one potential trail route.
Runyon said the biggest issue in connecting eastern Kentucky trails is the liability that property owners face when they allow the public to come onto their property.
There has been some effort at the state level to pass legislation to ease the property liability burden, but the state's tort law, allowing people to sue for various reasons, may prevent further success of that effort.
One bill passed the House last year, but it died without a vote in the Senate.
Runyon said the laws enacted by the legislature show progress.
“I do think there is a way around all of this if everybody can work together, and they truly do work together, and try to add all the needs of everybody involved,” she said. “I think we can make some progress.”
Areas like Harlan, Bell, Knott Leslie and Knott counties found ways around the liability issues and are able to market trails and host large-scale trail events because a large corporate landowner or private landowners with large, usable tracks of property provided a long-term lease to the county.
“Bell County is the new kid on the block,” Runyon said. “There was a company there that leased 7,600 acres to the county. They held an ATV event there three weeks ago that attracted 3,000 riders. So, it's possible to do this.”
Runyon said the local residents contacted by the Big Sandy ADD have reported that they are excited about the potential.
“The only resistance we see is the unknown,” she said. “If every county develops a block of property and show the locals that it will work, that people will come in here to ride these trails and there is economic benefit to that, then I think local landowners will want to get involved.”
She is asking all counties to assess properties that might be available for trail development.
The multi-county coalition will make the region more eligible to receive multi-county coal severance tax funds and grant funding for trail development projects, Runyon explained.
“We truly believe here that tourism will be an economic development engine,” Runyon said. “It won't be the only engine, but it will be a major economic tool for this region.”
Share and Enjoy:
Author: admin Categories: Community News, Uncategorized Tags:
Comments are closed.
Obituaries
County receives flood buyout money
RSS feed
Google
Youdao
Xian Guo
Zhua Xia
My Yahoo!
newsgator
Bloglines
iNezha
The Medical Leader on Facebook
Archives
January 2012
December 2011
November 2011
October 2011
July 2011
June 2011
May 2011
April 2011
March 2011
February 2011
January 2011
December 2010
November 2010
October 2010
September 2010
August 2010
July 2010
May 2010
April 2010
March 2010
February 2010
January 2010
December 2009
November 2009
October 2009
August 2009
May 2009
Search for:
Archives
January 2012
December 2011
November 2011
October 2011
July 2011
June 2011
May 2011
April 2011
March 2011
February 2011
January 2011
December 2010
November 2010
October 2010
September 2010
August 2010
July 2010
May 2010
April 2010
March 2010
February 2010
January 2010
December 2009
November 2009
October 2009
August 2009
May 2009
Meta
Log in
powered bySocialbar
Top
WordPress
Copyright © 2009-2012 The Medical Leader
Theme by mg12. Valid XHTML 1.1 and CSS


Marshall County Tribune: Stories from Wednesday, November
9, 2011
Enlarge text
Fair ~ 64°F   High: 72°F ~ Low: 56°FThursday, Mar.
1, 2012
Home
News
Sports
Opinion
Obituaries
Coupons
Classifieds
View All Listings
View Flyers
My Listings
My Wishlist
Stories from Wednesday, November
9, 2011
Finally Home
(11/09/11)
Veteran getting new home in Lynnville
Metro is 'hot potato;' Kennedy
(11/09/11)
Panel explores issue, asking
would mergers save money?
Holding tank base now in place
(11/09/11)
City utility project costs $13 million Approximately 1,000 cubic yards of concrete were poured Friday for the base of a cylindrical tank being built to hold 10 million gallons of wastewater at Lewisburg's treatment plant across Woodbine Avenue from the animal shelter...
Sheriff offers proper
disposal method for drugs
(11/09/11)
From staff reports Marshall County Sheriff Norman Dalton has installed a pharmaceutical drug disposal box in the lobby of the Marshall County Sheriff's Office. The program was implemented so area residents can properly dispose of old medications and not put them in the trash or flush them down the toilet...
Muck boots stolen from Farm Center
(11/09/11)
From staff reports Nearly a dozen pairs of muck boots have been reported missing from a store in Chapel Hill and Marshall County CrimeStoppers is asking the public to help police solve the crime. Sometime between the late evening hours of Tuesday and the early morning hours of Wednesday (Nov. 2) someone broke into the Chapel Hill Farm Center, 622 Depot St., Chapel Hill...
Crime Reports
(11/09/11)
Rodney S. Crosslin, 32, of Franklin Avenue, who allegedly fled police in a stolen car and crashed into two houses on Spring Street on Oct. 29, was transferred from the hospital to Marshall County Jail on Nov. 1. Crosslin is charged with theft of property and evading arrest. ...
CHES celebrates World School Milk Day
(11/09/11)
Who knew milk could cause such a frenzy? The folks at Chapel Hill Elementary School knew all along it would...that's why things were rocking all day as the students and staff celebrated the 12th anniversary of World School Milk Day on Sept. 28. The celebration started early as Cafeteria Manager Angela Lamb held a milk carton decorating contest and taste testing party featuring various dairy products during the school's breakfast period; several students and their parents were active participants in these fun events.. ...
Tigers defeat Notre Dame
(11/09/11)
Everything went according to plan for the Marshall County Tigers on Friday night, as they defeated the Notre Dame Fighting Irish 28-6 in the first round of the Class 4A playoffs at Preston Hopkins Field.
Mixing in some timely play action passes with their usually potent running game, the Tigers built a 21-0 lead in the first half before opening up a 28-0 advantage early in the fourth quarter en route to claiming their eighth victory of the year.
LMS Tigers too much for Whitthorne
(11/09/11)
The LMS Tigers made up for the opening season loss to Meridianville by taking out their disappointment on their always-strong namesakes from Whitthorne with a big 52-39 win in Lewisburg Thursday night.
Jay Howard's rebound and put-back opened up the scoring in the game for LMS, but Whitthorne's Sanchez Borkeen tied it up.
Tigerettes' first win a big one
(11/09/11)
After dropping their season opener to Meridianville, the LMS Tigerettes rebounded in a big way, defeating archrival Whitthorne in a spirited, down to the wire 30-27 contest in Lewisburg.
LMS's Makiya Morris turned in an outstanding performance, pouring in two-thirds of the Tigerettes' points in the game as she wove her way through traffic to the rack, pulled up in the lane for jumpers, stole the ball, ran the offense, and drilled two three-pointers.
CMS Lady Bulldogs double up Columbia Academy
(11/09/11)
On Saturday night, the Cornersville Middle School Lady Bulldogs (4-3) captured their second straight Cornersville Athletic Booster Club tournament title by defeating Columbia Academy 26-13 in the championship game.
CMS narrowly beat Columbia Academy 25-22 in their season opener on Oct. 20 and found themselves locked in a 9-9 tie with CA early in the third quarter of Saturday's contest.
CMS Lady Bulldogs crush Culleoka
(11/09/11)
Coming off a 35-31 win over Elkton in the first round two days earlier, the Cornersville Middle School Lady Bulldogs (3-3) advanced to the finals of the Cornersville Athletic Club Booster tournament by hammering the Culleoka Lady Warriors 35-11 in the semifinals on Thursday night.
Having lost 27-26 to Culleoka earlier in the season, the Lady Bulldogs put Thursday's game out of reach early and built a 24-5 lead in the first half before outscoring the Lady Warriors 11-6 over the final two quarters to coast to the 24-point victory.
Rockets run over Irish 35-0
(11/09/11)
The Houston County Fighting Irish knew what was coming in their 2A playoff opener Friday night, but could not stop the Forrest ground attack as the Rockets exploded with a whopping 457 rushing yards behind an attacking offensive line that paved the way for a 35-0 shutout win at the "Rock" in Chapel Hill.
The win was the first playoff triumph for Forrest (8-3) since 1992 and sends the Rockets on the road, under the lights to Decatur County Riverside (4-7) for a second round, Friday night match-up.
Garvin bags eight-pointer
(11/09/11)
Tate Garvin of Chapel Hill killed his first deer on the afternoon of October 29, the opening day of juvenile hunt in Tennessee.
Garvin's bagged buck had a nice eight-point rack, as wide as the young hunter himself with an 18" spread, and Garvin's prize came in field dressed at 125 lbs...
Brenda Jean Dalton
(11/09/11)
Brenda Jean Dalton, 62, of Smyrna, died Saturday morning, Nov. 5, 2011, in Nashville. Mrs. Dalton was born in Marshall County and was formerly a member of the environmental staff at McKendree Village in Hermitage. She was a member of Stones River Baptist Church...
Jerry Hicks
(11/09/11)
Jerry Hicks, 75, of Chapel Hill, died Thursday evening, Nov. 3, 2011. Mr. Hicks was born in Royalton, Ill., and was a son of the late Porter and Iva Pearl Snider Hicks. He rose to the rank of Private First Class during his service in the Army Reserves. ...
Wilton Collin Hand
(11/09/11)
Wilton Collin Hand, 75, retired Director of Tennessee State Industries with the Tennessee Department of Corrections and resident of Trotwood Avenue, Columbia, died Sunday, Nov. 6, 2011, at the Veterans Affairs Medical Center in Murfreesboro. A native of Hazelhurst, Ga., he was the son of the late Benjamin Bartow Hand and Elva Carter Hand. ...
George Thomison Jr.
(11/09/11)
In remembrance of George Thomison Jr., born on Dec. 4, 1928, to the late George Preston and Annie Fox Thomison; passed Nov. 1, 2011. Left


Date: Thu, 01 Mar 2012 16:07:16 GMT
Last-Modified: Thu, 13 Oct 2011 10:08:05 GMT
Server: IdeaWebServer/v0.70
TEAC VRDS25
Start Page
Update list
Speakers
Amplifiers
Transport
Lampucera
Alphabetical
Tripath
Download Lampizator
TDA1541A
VRDS-25 from TEAC
Related
articles:   T1 VRDS
transport,   Denon DCD2560
with same dac AD1862
Feb 2008
Teac has a hell of a reputation, I don't know why exactly. Nothing
special sets them apart but maybe they are a little bit better in
marketing than their peers. For example Philips invented so many
wonderful all the goodies, all best chips,
mechanisms, etc and they don't have even 10 % of TEAC reputation.
Maybe it is the VRDS thing - every hifi rag devoted countless pages
explaining the principle of very rigid disc clamping system - how the
pressure clamping disc "prevents the CD from vibrations" but in other
players nothing prevents the vibrations and yet they still manage to
play well. So to me it seems like TEAC created an antidote to a
non existent poison, and then they sold the whole concept as their key
differenciator and they had to invent the poison. Clever people.
Anyway, they took the stock, middle of the range SONY mechanism KSS151A
(like in Sony CDP227ESD player)
and added a large puck on top of it. Is it good or bad - I dunno, but
it looks positively hitech.
To be able to sell the story even better - in this VRDS 25 player (they
named the player after the mechanism name - see how important the
plastic puck is to their marketing?  Sortof like calling a car
Turbo.) they made the face plate of 10 mm solid aluminium and
everything
is oh-so-heavy.
To my big surprise - the main PCB is REALLY a very nice one. Almost
like in Copland. Premium parts, audio grade electrolytes, very very
neat auto-CAD of PCB layout, fully differential balanced topology and
OH MY GOD - the AD1862 super
duper chip. What a rare DAC. A white raven. To be found only in world's
best players, like for example in the best denon - the 2560.
This DAC has current output (the better, more kosher type) and it can
be lampized with R conversion. I used 570 Ohms which I had on hand.
I quickly cut the leg 11 of the chip from the PCB track (I mean I cut
the track leading from leg 11 to next parts - 4 opamps in a row per
phase.)
I wired the now freely floating leg 11 to lampizator leg 7 and then
from leg 7 to leg 9 - a resistor of 570 Ohms.
Surprisingly this player has balanced outputs.
Lampization is possible as SE ( RCA)  and balanced  XLR at
the same time.
I quite like plain and simple face plates like this one. The only minor
reservation in this player rating is it's very slow drawer.
Golden drawer in black player. Hmmmm.....
Great PCB - neat, simple, beautiful - everything is first class. Hats
off.
ASD-Audiotuning company from Germany offers upgrade replacement chips
for these two suckers on the picture's right - the demodulator and the
upsampler- NPC and the AD1893. The better parts from Mr. Andreas (we
paid some 100 Euro plus) are 24/192  compatible and the DAC is a
20 bit one. The clock is not typical - 18 ,xx meg. The upgrade allows
to squeeze the max from the 1862 DAC. It took me 10 minutes do de
solder and solder the upgrade.
I suspect that 1862 is the same as Burr Brown 1702. Something is
telling me ....
Enter Analog
Devices AD1862 N-J DAC chip
Four DAC chips in
a row. Mmmmmmm. Nice. One per channel per phase. They
go like this from bottom of the photo :  L-, L+, R+, L-. I took
the signal from the inner pair.
Please ignore the most right yellow wire - my mistake (left channel
phase neg). Top-most blue wire is the earth.
Test hookup of the lampizator. (traces are cut underneath the board to
free float the leg 11 of each DAC,  so it is not innocent kind of
reversible test.)
After good result from the test, I went for full lampization, internal
tubes, one per channel in anode follower mode - four triodes creating
balanced XLR outputs and RCA single ended too.
I started by removing the main PCB and installing Trichord 4 clock.
Below you see the crystal, two caps and a resistor that had to be
removed (18 meg crystal, not typical 16 meg.)
The new clock connects to the legs 1 of the 74HCU04 chip (signal) and
leg 7th - GND (see red lines).
The VRDS level two (middle) with composite bridge and cast alloy clamp
flywheel. Much much better than the ugly cheap level 1 CMK4 mechanism
from TEAC T1 (CD7)
Laser assembly and pickup is Sony KSS151A on magnetic rails - again -
very decent laser.
I simply love that PCB
As you see - this player has a transformer with dual primaries - 230
and 120 VAC. Good for all continents.
The XLRs and RCAs are so good quality that they do not need to be
replaced. They can stay.
The power supply section houses a nice, big, potted and encapsulated
transformer. Very nice. There is provision for 230/120 selection. The
raw supplies and rectifiers are heavy duty, oversized, and (whatever
that means) - FOR AUDIO. In my opinion that is BS because a cap can be
either good or bad, but FOR AUDIO means nothing.  Just marketing
buzzword.
You see the AUDIO caps and my new bolt for holding the transformer of
lampizator.
This is empty space under the main PCB where all my new power supplies
and filters will be located.
New transformer installed. I had two secondaries of 110 VAC so I used
them in dual mono config.
A tube (two triodes) in balanced mode is ideally supplied from ons
ingle source. If positive signal causes one tube to draw current MORE,
the negative impulse causes the other half to draw EQUALLY LESS.
Summary current demand is CONSTANT and this is very good.
This is main AC cable of TEAC with added parasitic Lampizator brown
twisted pair that is transformer primary.
This way the Lampizator is connected AFTER the switch, after filter of
AC noise and after fuses as well.
In the central section of the player where the mechanism is located -
there is additional large power supply section with 4 gigantic caps and
some other stuff. So the main PCB gets very good power.
Above you see the SPDIF digitall output section.  There is no
transformer for signal (good) and there is TOSLINK as well to the left.
It makes overall a nice transport, should you EVER want a DAC better
than internal AD1862.
The Lampizator power supplies are getting glued and wired together. On
the right - 12 V DC, on the left hand side - two high voltage anode
supplies (CRC filters and integrated bridges.
This is the resistor kit that goes on the socket. Two Cathode resistors
of 200 Ohms and two grid resistors of 240K. The twisted end becomes
system ground.
Lampizator circuit ready to go. Anode resistors are mounted away on
anode supply caps output. This makes the triode socket less congested.
Above: all power supplies are glued to the floor under the main PCB.
the long black thing is the power switch extension rod.
Dark red resistors connected to red wires are anode resistors in anode
follower setup.
The tubes were mounted above main PCB after I removed the analog output
stage - 8 op-amps and their capacitors. There was enough space for 2
tubes.
Red wires go to anodes of triodes. All grounds are connected together
in star fashion: both tube grounds, RCA's, XLRs, anode supply ground,
heater ground and main PCB ground.
XLR and RCA inputs were floated from the  PCB and freed.
Clock was powered from now un-used OPAMP supply of plus 12V DC (on the
copper rail.)
SOUND of TEAC VRDS-25
The sound is
right there with the top players. League zero - which stands for no
compromise, best CD playback under the sun. It is not a winner, but
definitely in the same league as the best ones I tried.
The sound is overall the safest all rounder. Not as goose bump magical
midrange timbre as the TDA1541 players, not as thunderous superbass as
Wolfson, not as crystal clear trebles as Lampucera DAC CS4397, and not
as deep deep hallucination as from BB-1794 of the Shanling CD300. But
it has no flaws or
faults. Very highly recommended.
The tube: Russian 6H2P (6N2P) with SRPP and 200 Ohms in both cathodes.
ECC88 and E88CC works great as well.
2 days later: a very enlightening listening session with a comparison
between Audionote DAC 2 signature (2 x PCM63)  driven by TEAC as a
transport versus
TEAC lampized. As good as the Audio-Note DAC2  is, the Teac
VRDS-25 walks over it. The
amount of hidden information that TEAC pulls from very familiar
recordings is just unbelievable. At the same time it is more powerful,
more spacious, and with stronger bass, which is  is controlled and
powerful. My admiration for the application of the AD-1862 grows. I
like equally well the DENON DCD2560
The Teac is better built, but DENON


X-Runtime: 648
Content-Length: 124284
Cache-Control: private, max-age=0, must-revalidate
Via: 1.0 sbnation.com
Vary: Accept-Encoding
Connection: close
CSC Community Mock Draft: The New England Patriots Select... - Canal Street Chronicles
Navigation: Jump to content areas:
Network Bar & Login
Section Navigation
Main Blog Content
Secondary Sidebar: Links to Recent Stories, FanPosts and FanShots
Masthead
Network Bar
SB Nation
Pro Quality. Fan Perspective.
Log In
Screen Name
Password
Remember
Forgot Password?
Sign in with Yahoo! ID
Sign in with Facebook
Use OpenID
OpenID
Remember
Don't Have OpenID?
Sign Up
Around SBN: NCAA Basketball Championship Week Guide
Canal Street Chronicles - Home of the Who Dat Nation...where pigs fly and hell has frozen over.
Home
FanPosts
FanShots
Archives
Saints
Schedule
Roster
Stats
Tickets
VideoOriginal programming. Exciting sports coverage. Check out the SB Nation YouTube channel!
CSC Community Mock Draft: The New England Patriots Select...
by Dave Cariello on Apr 20, 2009 6:00 AM CDT
in 2009 CSC Community Mock Draft
Tweet
3 comments
Email
Print
This pick and analysis was written by CSC member Hustl504. Thank you, once again, for your participation!
Jenkins slips all the way to the 23rd spot after the Saints passed him up. (Photo Source)
With the twenty-third pick in the Canal Street Chronicles community mock draft, the ew England Patriots select...
Malcolm Jenkins, CB, Ohio State
Here at CSC, we are all familiar with Jenkins. He's been at the top of our draft boards for the past couple years. He's got the size and ability to succeed in the NFL. I don't feel the need to elaborate on that. We like him. We want him. But in case you forgot, diehardbermysaints made a great FanPost enumerating the 3 reasons to pick Jenkins.Some may argue LB is the Patriots most pressing need. However, with Maualuga and Cushing off the board, I don't believe the Pats should reach for Lauranitis, Matthews, or Sintim at this point. Each one of them would fill a nice need for the Pats; Lauranitis with the leadership, Matthews with the pass rush, and Sintim with the experience in the 3-4. Despite this, one of them should still be available when the Pats pick again at #34, making Jenkins a better value for this pick. Aside from that, a nucleus of Mayo and Adalius Thomas is still serviceable when surrounded by midlevel talent. I don't really see the Patriots going any other direction here. Their offense is solid. The top OL prospects are gone. Their pass rush and defensive line could use some work, but I think that need would be better fulfilled later this draft. So, this pick came to the man us Saints fans have longed for since Jason David first stepped on the field in black and gold. It's a damn shame I had to give him to the Patriots.
The Atlanta Falcons are now on the clock...
Current Mock Draft
Pick
Team
Player
Position
College
CSC Member
#1
Detroit Lions
Jason Smith
OT
Baylor
MT_Always
#2
St. Louis Rams
Michael Crabtree
WR
Texas Tech
DeuceisLoose926
#3
Kansas City Chiefs
Aaron Curry
LB
Wake Forest
Satchmo26
#4
Seattle Seahawks
Eugene Monroe
OT
Virginia
MobileSaint
#5
Cleveland Browns
Brian Orakpo
DE
Texas
YESSaints
#6
Cincinnati Bengals
B.J. Raji
DT
Boston College
FriarBob
#7
Oakland Raiders
Michael Oher
OT
Ole Miss
Big and Easy
#8
Jacksonville Jaguars
Percy Harvin
WR
University of Florida
Drunk Monkey
#9
Green Bay Packers
Everette Brown
DE
Florida State
Sean McG
#10
San Francisco 49ers
Jeremy Maclin
WR
Missouri
Steve the fan
#11
Buffalo Bills
Aaron Maybin
DE
Penn State
BlackandGold4ever
#12
Denver Broncos
Matthew Stafford
QB
Georgia
Hustl504
#13
Washington Redskins
Andre Smith
OT
Alabama
natde1016
#14
New Orleans Saints
Brian Cushing
LB
USC
Saintsational
#15
Houston Texans
Chris Wells
RB
Ohio State
diesel0722
#16
San Diego Chargers
Rey Maualuga
LB
USC
Walter FTW
#17
NY Jets
Mark Sanchez
QB
USC
MobileSaint
#18
Denver Broncos
Tyson Jackson
DE
LSU
SaintsDynasty
#19
Tampa Bay Bucaneers
Peria Jerry
DT
Ole Miss
Steve the fan
#20
Detroit Lions
Josh Freeman
QB
Kansas State
SaintsDynasty
#21
Philadelphia Eagles
Knowshon Moreno
RB
Georgia
MtnExile
#22
Minnesota Vikings
Eben Britton
OT
Arizona
SaintsDynasty
#23
New England Patriots
Malcolm Jenkins
CB
Ohio State
Hustl504
#24
Atlanta Falcons
--
--
--
Dave the Falconer
Poll
Do you agree with this pick?
40%
Boom!
20 votes
59%
GAAAA!!
29 votes
49 votes
| Poll has closed
Tweet
3 comments
|
0 recs  |
Do you like this story?
More from Canal Street Chronicles
Fleur-de-Links: February 29, 2012
Feb 2012 by David "Satch" Kelly
- 45 comments
Fleur-de-Links: February 27, 2012
Feb 2012 by David "Satch" Kelly
- 7 comments
Oscar Sunday Fleur-De-Links: February 26, 2012
Feb 2012 by Hans Petersen
- 2 comments
Fleur-de-Links: February 24, 2012
Feb 2012 by David "Satch" Kelly
- 0 comments
Forgiving Malcolm Jenkins
Feb 2012 by Jack Sharkey
- 11 comments
Fleur-de-Links: February 17, 2012
Feb 2012 by David "Satch" Kelly
- 0 comments
Read More: Malcolm Jenkins (CB - Ohio St.), New Orleans Saints, Ohio St. Buckeyes, New England Patriots
Sign in with your Yahoo! ID
Add Canal Street Chronicles to My Yahoo!
Comments
Display:
Expanded
Collapsed
Great write-up!
Come on guys, I see the “GAAAs” outnumber the “Booms!” in the poll. Who doesn’t agree with this pick?
Go Saints!!!! Deuce may be gone, but he will never be forgotten.
by David "Satch" Kelly on
Apr 20, 2009 3:51 PM CDT
reply
actions
No I want to vote for boom and GAAAAA!
Boom because it’s a good pick, and GAAAA because we should have picked him – Ha!
The Detroit Lions are on the clock!
by Hans Petersen on
Apr 20, 2009 6:16 PM CDT
reply
actions
If the Pats really do get him, I am going to be bitterly disappointed.
"The best hope for David to make the final roster is for the Saints to select players at other positions in the draft."- Jeff Duncan, T-Pic 4/8/09
by stujo4 on
Apr 20, 2009 8:13 PM CDT
reply
actions
Comments For This Post Are Closed
↑ Top of comments
↑ Top of page
↑ Stories
↑ Canal Street Chronicles
↑ SB Nation
Secondary Sidebar
Search
User Tools
in association with
The ultimate community for lovers of all things Black and Gold! The latest news, commentary, discussion, linkage and more! Join in the conversation now with all of your fellow Who Dats!
Start posting about the Saints
Sign up for the Saints Newsletter
Canal Street Chronicles on Facebook
Follow @CSCtweet
Follow
Canal Street Chronicles on your Android Device!
Subscribe to Canal Street Chronicles Stories
Related FanPosts on Canal Street Chronicles
Random Thoughts While My Blood Pressure Slowly Recovers
by MtnExile about 1 month ago
62 comments
Malcolm Jenkins (and maybe the coaches) deserves credit for adjusting to the rules
by BlackandGold4ever 2 months ago
3 comments
| 1 recs
Accountability Index Update
by stujo4 3 months ago
22 comments
Updated Season Predictions
by Alex Swift 3 months ago
5 comments
Accountability Index Update
by stujo4 4 months ago
81 comments
| 1 recs
Accountability Index Update
by stujo4 5 months ago
26 comments
| 3 recs
Related FanShots on Canal Street Chronicles
thank you for your forgiveness! Lol Like you I am excited about this...
by Dave Cariello
1 day ago
13 comments
Four players missed practice for the New Orleans Saints on Wednesday --...
by Hans Petersen
2 months ago
0 comments
Saints aren't tolerating mistakes in their pass defense
by stujo4
3 months ago
13 comments
|
1 rec
... the defense is doing exactly what we need to do as far as holding...
by stujo4
3 months ago
19 comments
'Stonewall' Jenkins was the impenetrable force for the New Orleans Saints: Film study
by Dan Kelly
4 months ago
1 comment
New Orleans Saints at Jacksonville Jaguars: Inside the game
by Hans Petersen
5 months ago
0 comments
FanPosts
Community blog posts and discussion.
Recent FanPosts
Contracts Should Be Restructured
by SaintsRule2011 1 day ago
7 comments
The Gregg Williams Experience: A Retrospective
by ugarte 2 days ago
19 comments
CSC Lagniappe: #14 Drinking, Hunting and Fishing
by cajuncommando58 5 days ago
62 comments
| 4 recs
Saints need to get creative
by Ajun Cajun 5 days ago
10 comments
John Kasay Connects with Charlotte Faithful
by UCNCFootball 6 days ago
0 comments
What about...Peyton?
by FrenchFreak 9 days ago
93 comments
To Franchise or not to Franchise is the question.
by jeremysherwin 10 days ago
10 comments
*Poll* Is the NFL hurting the entertainment value of the game?
by dubzfan 11 days ago
21 comments
More Draft Options Cornerback and Safety...
by cajuncommando58 12 days ago
4 comments
Calling all "newbies"
by FrenchFreak 14 days ago
318 comments
| 1 recs
+ New FanPost
All FanPosts >
Recent Posts
Fleur-de-Links: March 1, 2012
Da Chronic Podcast Graphic Design Contest
SB Nation Launches YouTube Channel: Subscribe Now!
Fleur-de-Links: February 29, 2012
Saints vs. Cardinals to Open Preseason in Pro Football Hall of Fame Game
Forgiving Malcolm Jenkins
Saints Sign Arrington, Colston Now Free to Explore Free Agency
Fleur-de-Links: February 28, 2012
One Player, One Combine Performance, Two Completely Different Opinions
NFL Combine 2012: Monday Recap
Featured Poll
Poll
Which Saints regular season was better: 2009 or 2011?
47%
2009
402 votes
52%
2011
446 votes
848 votes
| Poll has closed
In Association With
Shutdown Corner - NFL
- Yahoo! Sports
Chargers’ Kris Dielman, ‘the ultimate old-school, self-made player,’ retires in emotional press conference
ESPN changes Hines Ward headline after some make ethnic connection
The Hillis Identity: Running back of CIA agent?
Packers raised $70 million from sale of stock
Hines Ward to be released after 14 seasons in Pittsburgh
Visit the New Orleans Saints Topics page on USA TODAY
Latest NFL news, notes, buzz, analysis on The Huddle
New Orleans Saints news and rumors from NFP
Report: Saints trying to create more salary-cap room
Receiver Roulette: Part 2
'Skins targeting receivers in free agency
Carl Nicks: 'I don't want to be franchised!!!!'
Cardinals, Saints will play in Hall of Fame Game
SBNation.com Recent Stories
NFL Free Agency 2012: WR Market Not As Impressive After Franchise Tags
+3 updates
Eagles Free Agency 2012: DeSean Jackson Gets The Franchise Tag
Longtime Steeler Aaron Smith To Be Released, According To Report
More from SBNation.com >
Vox Media Hot Topics
2012 NFL Mock Draft
UFC
NCAA Tournament 2012 Schedule
NBA Trade Rumors
Daytona 500 2012
NFL Draft 2012
Community Masthead
Head Coach
Dave Cariello
Assistant Coach (Editor/Contributor)
Hans Petersen
Andrew Juge
Offensive Coordinators (Contributors)
David "Satch" Kelly
Jack Sharkey
Alex Swift
Preston J. Gary, Jr.
Travis Dauro
Jimmy Angel
Win Ellington
Copyright © 2012 Vox Media, Inc. All rights reserved.
Newsletter Signup
About Us
Frequently Asked Questions
Terms of Use
Privacy Policy
Guiding Principles
Advertise With Us
Contact Us
Certain photos copyright © 2012 by Associated Press or Getty Images. Any commercial use or distribution without the express written consent of Associated Press and Getty Images is strictly prohibited.
OpenCalais - Powered by Thomson Reuters
•
Odds Shark
SB Nation Newsletters
Saints Fan: Get the 5 biggest Saints stories, hand-picked for your inbox.
Show more info?
We’ve developed a unique email newsletter that delivers the five most interesting Saints
stories fans are talking about every week. Each email is curated by an SB Nation editor who follows the Saints


Planning Board Meeting Minutes 2006
Link back to department page
Minutes June 26, 2006Regular MeetingPlanning Board Agenda for Monday, June 26, 2006
Scheduled:7:00 PM 36 Talbot Road Proposed 3-Lot Subdivision8:00 PM South Shore Baptist Church, 20 Free Street Continuation of Public Hearing - Special Permit A-3: Parking Determination9:00 PM 309 Whiting-Request for Lot Release 9:15 PM Viking Lane-Request for Extension to 8/1/07Central Meeting Room North      Present: Planning Board Members, Susan Murphy, Chair, Paul Healey, Clerk, Tod McGrath and Judy Sneath.  Also present was Planner Katharine Lacy.
Ms. Murphy opened the public meeting at 7:00 P.M. at the Hingham Town Hall.
RE:  36 Talbot Road Proposed 3-Lot Subdivision
Present for the applicant: Robert Devin, Attorney, and Al Trakimas engineer, SITEC.
Ms. Murphy started the meeting by stating that following material was requested and has not yet been submitted.
1. Title Information on 36 Talbot from Attorney Robert Devin and review by Hingham Town Counsel2. Detailed grading plans showing a blow-up of the area adjacent to the Fee's driveway3. Report from the Board of Health
Mr. Devin stated that he would provide the title information as soon as possible, and Al Trakimas noted that he had just received a draft plan showing the detailed grading around the Fee's property.
Ms. Lacy explained that plans were submitted to the Board of Health on April 21, but the applicant has not submitted the required $3,000 review fee so no review has taken place. The law states that the Board of Health has 45 days to review the plan, which expired at the beginning of June. The Board of Health, however, states that the application period had not yet begun, because the application without the fee was not complete.
Mr. Brogna identified  the following five waivers that the applicant was requesting, as outlined in his letter dated June 26, 2006:
1. The proposed roadway construction will extend the length of Simmons more than 800'. The Planning Board Rules and Regulations state in Section 4, Design Standards, B (4) (a) that a dead-end street shall not be longer than 800' in length.2. Hingham Zoning By-Law, Section 111-C Flood Plan and Watershed Protection District, paragraph 2.a. - "no building.shall be created."  It would appear that the proposed location of the dwelling on Lot 1 falls within the 10' MSL contour.  The applicant should review Lot 2 for this issue, as well.3. Hingham Planning Board Rules and Regulations, Section 4, paragraph C (3) (b) "manhole inlet and outlet inverts shall be at the same elevation".4. Hingham Planning Board Rules and Regulations, Section 4, paragraph D (Open Drainage Systems) "in no case shall side slopes in disturbed areas be greater than twenty-five (25) percent 4H:IV".  It would appear that there are areas on the plans that exceed this 25%.5. Hingham Planning Board Rules & Regulations, Section 4, paragraph C (3) (g) "Where the Planning Board determines that the public interest and the best interest of the Town and the subdivision will be served by extension of the drainage system outside the boundaries of the subdivision, the Planning Board may required the Applicant, at his own expense, to continue the layout and construction of the drainage system.". The extension of the Rice Road drainage system is the issue. The proposed extension of the piping at the end of Rice Road into a stone swale would require a waiver here.
Ms. Murphy asked the Board to consider, given the waivers that the applicant was requesting, whether they were willing to proceed with the hearing and hear the applicant's full presentation. Board members agreed to continue the hearing.
Al Trakimas provided an overview of the proposed roadway drainage, which would include traditional subsurface pipes leading to two catch basins at the throat of the cu-de sac. Water would flow from the basins into two Vortechnics units and through a series of stepped manholes, ultimately discharging at the wetlands below.
Roadwork would begin at the two existing catch basins on Simmons Road, where the applicant proposed to saw cut and match the existing pavement. The roadway would slope down to the west at approximately 8% grade, flattening out at the cul-de-sac to 3%. The cul-de-sac would be 120' in width.
A 4" water line would be hooked up to the existing 2" water line on Simmons Road. A new hydrant would be located in the cul-de-sac, serving this new portion of Simmons Road. Mr. Trakimas said that they had looked into the possibility of looping the water line at Rice Road, but that Aquarion Water co. had indicated that this would not be possible.
Mr. Trakimas acknowledged that the project design included several side slopes which exceeded that maximum 2:1 slope. He pointed out, however, that if you just looked at the construction of the roadway, and not the adjacent lots, that the extent of excessive side slopes was greatly reduced. The actual house locations shown on the plans were conceptual in nature, when in fact they could be placed in other locations. Board members questioned the logic behind taking this approach towards the review of the project, and Mr. Devin responded that "you have to start somewhere" in terms of project approval. Paul Healey asked if this would mean that house foundations would have to be built into the fill put in place to create the elevation for the roadway. Mr. Trakimas responded that it might.
Paul Healey asked what the downside of the proposed "stepped manholes" would be in terms of the functionality of the drainage system. Al responded that this type of stepped system is common for sewer systems. Susan Murphy asked Paul Brogna to look into this and report back at the next meeting.
Al Trakimas finished up by stating that utility companies had all been contacted, and had provided their preliminary approval of the plans.
Judy Sneath asked whether the construction of the roadway would impact the single family lot owned by D'Allesandro on the south side of Simmons Road adjacent to the proposed subdivision. Mr. Trakimas responded that the grading for the roadway would cut into this property. Ms. Sneath expressed concern about the quality of the filled soil on that lot. Paul Brogna was instructed to look into industry standards for the type of soil permitted for side slopes.
Judy Sneath and Paul Healey asked why this lot was not part of the subdivision. Mr. Devin explained that it would be a legal Form A lot should the road be extended.
Tod McGrath asked about the quantity of fill that would be required to build this project. Mr. Trakimas responded that if the house lots were to be built it would require 7000 cubic yards of cut and 17000 cubic yards of fill. To bring in the fill would require 400-600 dump trucks of fill to be brought to the site. For just the roadway to be built it would require 2,300 cubic yards of cut, and 7,000 cubic yards of fill, or a net of 5,000 cubic yards of fill (200-400 dump trucks). He explained that a staging area would be created to the dump trucks to turn around.
Susan Murphy pointed out that if houses were to be built on these lots they would require a variance from the height by-law in that the bottom of the basement slab would be more than five feet above the existing grade. She pointed out that subdivisions can be denied if they assume noncompliance with zoning.  Tod McGrath asked why the developer would want to proceed with this project when they might only get to develop one lot. Susan Murphy asked if they could build the project without the waivers. Al Trakimas responded that it would be very difficult, but that it could be done using extensive retaining walls. Susan reiterated her concern about how the Fee's property would be impacted by the extension of Simmons Road, and pointed out that the Subdivision Control specifically states that new subdivisions linking to existing subdivisions cannot damage or harm the properties on the existing roadways.
Abutters expressed concern about the impacts of construction on the neighborhood during construction including truck traffic and noise, damage to a public way, disruption and removal of potentially toxic materials, and difficulty for emergency access.
The hearing was continued to July 24 at 8:00 PM.
RE:  South Shore Baptist Church, 20 Free Street Continuation of Public Hearing - Special Permit A-3: Parking Determination
Present for the applicant: Robert Pomereine, Attorney and Brad Warner, President of the Board of Elders. This was a continuation of a hearing initiated on June 13, 2006.
The applicant is currently applying for a Special Permit A-3 (parking determination) in connection with a change of use of the property at 20 Free Street from a residence to church offices. The applicant is requesting 1) a determination under Section V-A that the applicant may provide all parking required for 20 Free Street at 578 Main Street, with the exception of handicapped access parking, and 2) a determination that the proposed use of the property at 20 Free will NOT intensify the church use (and thus the required parking for the property as a whole), as the church contests that the new office space will simply replace operations that will be housed at 20 Free are already in existence in the church and 3) approval of the Site Plan showing modifications to the property at 20 Free Street.
Ms. Murphy opened the hearing by noting that letters had been received by Pat MacAllen and Jim MacAllen expressing concern with the proposed use of 20 Free Street for church office use. Ms. Murphy also followed up with a report from Ms. Lacy regarding past Special Permits issued for the church indicating that there were no conflicts between the request currently before the Board and existing permits. She noted that the when the church received a parking determination in 1987 indicating that 150 parking spaces was sufficient, and that they now have 175 spaces. While the church population may have increased, in terms of how parking needs are required (by number of seats and square footage of office/classroom use) the church still complied with this original determination.
Brad Warner presented the revised site plan showing a pervious paved walkway located approximately 25' from the western property line, and vegetative screening on the western property boundary with the adjacent house. He explained that screening was not put in on the other side due to the presence of existing vegetation and the fact that the garage for the abutting property was located right on the property line blocking views.  Mr. Warner reiterated that the use of the building did not represent an increase in the intensity of use at the church, but simply a relocation of uses from the church building to 20 Free Street.
Abutter Mary Ellen McCabe noted that she wanted screening along the entire length of her property.
At 8:45 Paul Healey made a motion to close the hearing, and vote to issue the Special Permit A3 with conditions. Tod McGrath seconded the motion and all approved.
The Board began deliberations on the proposed conditions to the permit. Board members agreed that the request for relief from the requirements of the parking by-law was appropriate, and that there was sufficient parking at the church to serve the uses that would be housed in the church and at 20 Free Street. They recognized that the use of the building did not represent an increase in the intensity of use at the church, but simply a relocation of uses from the church building to 20 Free Street.
Mr. Healey acknowledged that the path leading from the church to the house at 20 Free Street could represent an invasion of privacy for the neighbors by inviting the public into the traditionally private realm of backyards. Board members determined that additional screening should be provided on the west side of the property to screen the abutters at 22 Free Street.
Board members discussed the potential difficulties associated with enforcing many of the conditions proposed by the abutters associated with the use of the property during non-business hours and by groups of adults. Tod McGrath pointed out that the proposed building layout, consisting of small office spaces, did not seem conducive to group gatherings. Judy Sneath felt that placing too many constraints on uses would, in effect, turn the neighbors into "spies" having to check and determine whether the activity was permitted or not.
Mr. Warner reiterated that persons using the 20 Free Street building in the evenings and at all other times will be expected to respect the interests of neighbors, as would any good neighbor.
The Board voted to attach the following conditions to the Special Permit A-3: 1. A 4-foot path surfaced with a "nonpermanent", plowable surface such as brick or paving stones will be installed from the house at 20 Free Street to the main parking lot at 578 Main Street. The path will be located as shown on the Site Plan of the 20 Free Street property last revised 6/14/06.
2. Path lighting will be limited to low level lights located at ground level. Prior to installation, proposed walkway lighting will be reviewed by the Town Planner.
3. The intermittent porch light on the east side of the building illuminating the driveway will be replaced with a lower wattage fixture pointing downwards and away from abutting properties.
4. Vegetative screening shall be planted along the west property lines for approximately 150' from Free Street northward to a point parallel to the shed at 22 Free Street.
5. Parking at 20 Free Street will be limited to the one American Disabilities Act compliant parking space as shown on the plans. Parking will not be permitted on the grass lawn areas in front or in back of the building at 20 Free Street.
6. Use of the building at 20 Free Street will be limited to the following:
a. office and/or desk space for 4-7 Church pastors and staff for pastoral, clerical and administrative functions, space for pastors, staff, church officers and elders to meet with church members and other persons for Church business and ministry activities, and space for storage of supplies and other church property;
b. visits to pastors or other church staff by members of the congregation and other visitors including those inquiring about becoming involved with the church, for prayer, Bible reading, obtaining advice, mentoring and information, Biblical teaching, and other church-related purposes;
c. normal week-day business hours on Monday through Friday from 8:00 AM to 5:00 PM;
d. use at other times as needed on weekends and in the evenings for church office activities as described above, in particular pastors working on evenings or week ends studying or preparing sermons or meeting with people, and church pastors officers, staff and elders conducting church business and ministry activities, and making copies, retrieving files, and making phone calls.
7. There will be no indoor or outdoor infant, child or youth group activities at 20 Free Street.
8.  The church will have an open door to the neighbors about any nuisance or disorder that may arise from the use of 20 Free Street, and will work with the neighbors and the Town to resolve any issues in a mutually agreeable manner.
9. Prior to the issuance of the building permit a revised Site Plan will be submitted to the Planning Board and Building Commissioner reflecting all applicable conditions identified herein.
The hearing was closed.
RE:  309 Whiting-Request for Lot Release
Mr. David Bowering came before the Board to request the release of the lot at 309 Whiting Street. The Board's consulting engineer, Paul Brogna, had inspected the site, and prepared a "cost to complete" indicating that a bond in the amount of $3,500 would be sufficient to cover the cost of completing the roadway plus contingencies.
It was moved, seconded and SO VOTED, to release Lot 2 (Land Court lots 3, 4 and 5) from the Subdivision at 309 Whiting Street, contingent upon the applicant posting a bond in the amount of $3,500.
RE:  Viking Lane-Request for Extension to 8/1/07Ms. Lacy requested that the Board postpone this vote until she get a better sense whether they have appropriately dealt with erosion control on the cleared site. Ms. Murphy asked how many times this project had been extended, and Ms. Lacy noted that it was approved in 2001. Ms. Murphy asked that Mr. Murphy to come before the Board at a meeting in the near future to discuss why the project has not been moving forward.
Unscheduled: Old/New Business
RE:  Form A - 400 Cushing Street, Boston Golf Jeffery Tocchio presented this Form A to the Board on behalf of applicant John Mineck.
This Form A would create a house lot within the Boston Golf Club. John Mineck has conferred with the Board of Appeals, and the creation of this new lot will require a modification to the Special Permit for Boston Golf. He will be held to this before a building permit is issued for the new house.
It was moved, seconded, and SO VOTED, to accept the Form A entitled, "Approval Not Required Plan of Land 400 Cushing Street Hingham, MA  02043", dated June 9, 2006, prepared by Coler and Colantonio, Inc., Norwell, MA, for John DeMatteo II, 405 Cochituate Road, Suite 203, Framingham, MA, owner and John Mineck, 289 Whiting Street, Hingham, MA, applicant.
RE:  Review Proposed Minor Modification to Back River CondosMs. Hastings proposed a minor modification to the Back River Condos to the ZBA, and they requested that the Planning Board take a look to make sure that it would not require Site Plan Review. The change involved moving one unit from one 4-unit complex to an adjacent 3-unit complex. The Board


IU drops Big Ten opener
Published on Decatur Daily Democrat (http://www.decaturdailydemocrat.com)
Home > IU drops Big Ten opener
Iu drops Big Ten opener
By editor
Created 12/28/2010 - 9:53am
12-28 Rivers gurd .jpg [1] RIVERS ON DEFENSE — IU guard Jeremiah Rivers (right) moves in position to cut off an opponent in a recent game. IU fell to Penn State Monday in the Big Ten opener. (DDD Photo by Les Conrad)
By
The Associated Press
BLOOMINGTON, Ind. (AP) — Jeff Brooks had a career-high 23 points and Talor Battle added 19 to help Penn State hold off Indiana 69-60 on Monday night.
The Nittany Lions (8-4, 1-0 Big Ten) snapped a two-game losing streak with their second straight win at Assembly Hall — a venue where they had lost 15 straight before finally winning a game two years ago. The two teams met only once last season, in State College, Pa.
Indiana (9-5, 0-1) has lost three straight and saw its nine-game home winning streak end. Verdell Jones had 15 points and freshman Victor Oladipo scored 14 points in his first career start.
Penn State, the worst shooting team in the Big Ten coming into the game, started 7 of 10 from the field. The Nittany Lions used four straight 3-pointers in a 12-3 run and followed that with nine straight points to take a 25-11 lead midway through the first half. Penn State led by as much as 30-16 before Indiana finally started to rally.
Oladipo made 1 of 2 free throws, Jones hit a 3 and Jeremiah Rivers scored on a putback to get the sluggish Hoosiers within 30-22.
It was the first real burst of energy for Indiana — but not the last.
After trailing 34-25 at halftime, and the Hoosiers charged back quickly in the second half.
Jones made a 3 to trim the lead to 35-30, and Jordan Hulls hit another 3 with 16:58 to go to make it 39-36. Rivers’ layup with 12:43 left got Indiana within 45-42, and then Maurice Creek finally got started.
Creek’s leaning 2-footer made it 45-44, his 17-footer cut the deficit to one and then he drove the baseline for a layup to give Indiana a 48-47 lead with 8:46 to go. It was Indiana’s first lead since 5-2.
Brooks, who pestered Indiana all night, followed that flurry with back-to-back baskets, and the Nittany Lions never trailed again.
Indiana did get within 53-52 with 4:04 to go when Jones made 1-of-2 free throws and had a chance to regain the lead but Jones missed a long jumper inside of three minutes.
Penn State answered with a 9-2 run that made it 62-54 to seal the outcome.
David Jackson had 15 points and eight rebounds for Penn State, while Hulls had 13 points for Indiana.
Hoosiers forward Christian Watford finished with three points — failing to reach double figures for the first time this season.
Decatur Daily Democrat
513fe8b5cc17799e1aad
Decatur, IN
Copyright 2010 Decatur Daily Democrat
Staff Writer
Local Sports
Copyright © 2012 The Decatur Daily Democrat | 141 S. Second Street | Decatur, IN 46733
| (260) 724-2121
All property rights for the entire contents of this publication shall be the property of The Decatur Daily Democrat


MAA - Spring 2008 - Donald H. Gilden, '63
On the Heels of MS
Donald H. Gilden, ’63, knew the moment he touched the dying man’s cold hand he wanted to become a doctor. He was just five years old when he made his decision. His grandfather had taken him to visit a friend who was dying of congestive heart failure and was surviving in an oxygen tent. Young Gilden was under strict orders not to disturb the man, but he disobeyed his grandfather slipping his hand under the tent. The old man squeezed the boy’s fingers and told him stories about his grandfather.
“After that day I never stopped talking about it,” says Gilden, professor and chairman of the department of neurology and professor of microbiology at the University of Colorado School of Medicine. “I was going to be a doctor when I grew up. I never wanted to do anything else.”
Gilden, age 70, has indeed made his mark on the profession. He is recognized as a pioneer in the field of neurovirology for groundbreaking work relating to shingles and multiple sclerosis (MS).
After nearly 150 years of medical speculation, Gilden discovered that varicella zoster virus—the virus that causes shingles—is latent in human ganglia. More than a million people a year suffer from shingles, and his work helped lead to a shingles vaccination.
He has also been working to track down the virus he believes causes MS, a disease that affects about a quarter of a million people in the United States. But this has been far more challenging. Yet Gilden is focused on what he wants to accomplish and understands that it will perhaps take the rest of his life, or even longer, to reach answers. “You have to be patient,” he says. “Science goes little by little. Progress is little by little.”
For his work, Gilden has received an alumni award for distinguished service from the University of Chicago School of Medicine, the International Society for NeuroVirology Pioneer Award, and, in May, he will receive the Medical Alumni Association’s Honor Award and Gold Key, presented for outstanding medical accomplishments and distinguished service to mankind.
A neurologist by training, Gilden sees patients who suffer from migraines, multiple sclerosis, Alzheimer’s, stroke, and Parkinson’s. “I will see anyone,” he says. “Clinical neurology has always been one of my first loves.” But most of his time is spent in the lab conducting research in the microscopic world of DNA, RNA, viruses, and proteins. “Sometimes in the lab my head is spinning because we have big things going on,” Gilden says.
As a boy growing up in Baltimore, Gilden’s world revolved around school and working summers in the family business, Sam Gilden & Son, a wholesale store that supplied hair tonic, razor blades, bobby pins, toothpaste, and other items to local drug stores. He unloaded trucks, packed orders, swept floors, and, when he was old enough, made deliveries in a bright red Dodge delivery truck His father saw him taking over the business one day, a task which demanded hard work and long hours. “We never had dinner with my father,” Gilden recalls. “The wholesale business was a tough business.”
Gilden’s real “job” was to go to school, and he excelled in biology, chemistry, and math. Classes in foreign language, however, barely held his interest. “For me the language of medicine was all I ever cared about,” he says.
He graduated from Dartmouth College in 1959, and moved back home to go to medical school. Gilden interned at the University of Illinois Hospital in Chicago, and did his residency in neurology at the University of Chicago Hospitals.
It was in the late 1960s while he was a staff neurologist in the US Army at Walter Reed Army Medical Center in Washington, DC, that he became interested in research. After seeing patients during the day, he had time to catch his breath in the evening and mull over the amazing research underway. Researchers had discovered that measles virus in the brain could cause chronic encephalitis, and that Jakob-Creutzfeld disease—a “degenerative” brain disorder in humans—was infectious.
“I said to my wife, ‘I think I want to do a fellowship in infectious diseases,’” recalls Gilden, who was 32 at the time. “She looked at me like she married a crazy man.”
He was accepted at the Johns Hopkins University School of Hygiene and Public Health as a postdoctoral National Institutes of Health fellow. After about three years, he joined the faculty at University of Pennsylvania and set up a lab at the Wistar Institute in Philadelphia to find the virus that causes MS.
He worked closely with MS patients who lived in a chronic care facility and were ravaged by the disease. Gilden asked if they would donate their brains after death to his research because he was looking for the cause of MS. Sometimes his phone rang in the middle of the night and within an hour Gilden was harvesting brain from their skulls. “I had my own saw,” he says.
He studied 24 brains over eight years, but never found the MS virus. So, he turned his attention to varicella zoster virus, which causes chickenpox in children and shingles in adults. Nobody had ever isolated the virus, and if he could prove it was there he believed he could use the same technique to find the MS virus.
He tore into his work mapping the viral genome in human ganglia along the entire nervous system. In 1983, he proved for the first time that the virus was latent in ganglia and “reawakens” causing shingles. The shingles virus causes pain and even stroke if it makes its way to the brain.
Gilden found several other diseases caused by the virus, such as zoster sine herpete, or shingles without the rash. His discoveries led to more work for his team.
Gilden left the University of Pennsylvania in 1985 to become professor and chairman of the department of neurology at the University of Colorado School of Medicine and professor of microbiology.
At the University of Colorado, 15 members of Gilden’s team are working on varicella zoster virus and MS. They harvest ganglia collected from an autopsy room. “We go there every day,” Gilden says. “If it is a good case we will go as far as we have to. We even get specimens from Japan.”
MS has been a hard case to crack, but Gilden seems to be making progress. The common theory is that MS is autoimmune. The body’s immune response attacks a protein that is normally in the brain. The attack is so violent and persistent that the brain is destroyed in the process.
“We don’t think that is the case at all,” Gilden says. “Even now we have evidence that it is not autoimmune.” He argues that in people with MS who have increased amounts of an antibody called immunoglobulin G (IgG), in their brain and spinal fluid, the IgG is directed against an infectious agent, but nobody is quite sure at what agent it is directed.
He and his team are looking for footprints of virus in MS. “We are writing a paper showing that the immune response in MS is not against a self (auto) protein,” he says.
While he is busy with his research, Gilden, who is married and has three adult sons, skis and plays the violin—a 1779 Guadagnini. He is also quick to tell
a joke.
Gilden would like to find out what causes MS and how to prevent varicella zoster virus from reactivating. He is unfazed by the fact that his research into MS


ALLELE 4 OF MHC CLASS I CHAIN RELATED GENE A INCREASES THE RISK IN LATVIAN PATIENTS WITH JUVENILE RHEUMATOID ARTHRITIS
ALLELE 4 OF MHC CLASS I CHAIN RELATED GENE
A INCREASES THE RISK IN Latvian PATIENTS WITH Juvenile Rheumatoid arthritis.
CB Sanjeevi, Ija Cimdina, A Shtauvere, M
Ghaderi, I Rumba. Karolinska Institute, Stockholm, Children Hospital of
Riga, Sweden and Latvia.
Juvenile Rheumatoid arthritis (JRA) is a heterogeneous
disease consisting of several clinical subgroups. It is an autoimmune disease
associated with the HLA class II genes. It is negatively associated with
HLA-DR1-DQ5 in Latvians. DR1-DQ5 was also decreased in seronegative patients
compared to seropositive patients in Latvian JRA. In addition to HLA, we
looked for an additional second susceptibility loci for JRA in Major Histocompatibility
Class III region. MICA gene is located in the MHC class III region and
is expressed by monocytes, keratinocytes and endothelial cells. Sequence
determination of MICA gene identifies trinucleotide repeat (GCT) microsatellite
polymorphism, which identifies 5 alleles with 4,5,6 and 9 repetitions of
GCT or 5 repetitions of GCT with 1 additional nucleotide insertion (GGCT).
The alleles are A4, A5, A5.1 , A6 and A9. The aim of our study was to find
the association of MICA alleles with JRA patients (n=119) and healthy controls
(n=108) from Latvia. The samples were analysed for MICA by PCR amplification
and fragment sizes were determined in ABI prism DNA sequencer. HLA-DQ was
genotyped by PCR-SSO.
Allele 4 was significantly increased in patients
(40/119, 34%) compared to controls (19/108, 17%)(OR=2.37, p<0.01, Pc<0.05).
4/5.1 genotype was also significantly increased in JRA patients (22/119,
18%) compared to 7/108 (6%) controls (OR=3.27, p<0.01, Pc<0.05).
5/5.1 genotype was decreased in JRA patients (4/119, 3%) compared to 13/108
(12%) controls (OR=0.25, p<0.01, Pc=ns).
In conclusion, allele A4 of MICA is increased in
JRA patients compared to healthy controls and 4/5.1 genotype also increased
in Latvian patients with JRA. Our findings suggest that MICA may play an
important role in the etiopathogenesis of IDDM


20 « December « 2011 « Wave Without A Shore
Home
About me
Genealogy: a hobby of mine...
TROUBLESHOOTING your e-books on computers AND e-readers
E-publishers and Small Presses of Note
Contact Info
Writing for Fun and Profit
spoiler potential: caution: book questions.
About the Foreigner series: Spoiler alerts
Alliance-Union books: spoiler alert
Fantasy books: Spoiler alert.
Gene Wars Universe: Spoiler Alert
CLOSED CIRCLE QUERIES AND FAQS
Linguistics
EBOOK DOWNLOAD TUTORIAL
Book Discussion: all books: spoiler alert in effect...
THE S&S PROJECT
Foreigner Guidebook.
Alliance-Union Guidebook
Bookbinding: How to.
Foreigner Series: Spoiler Alerts: Page 2
The Map Room
Wave Without A ShoreC.J. Cherryh's Own Weblog: e-books, science fiction and fantasyCommentsPosts
BUY NEW BOOKS
Vampires Strike Closed Circle!
Closed Circle Websites
Calibre: DRM-free books
our books on Calibre’s listing of DRM-free books. Calibre has been with us from the beginning and is a great software, too.
CLOSED CIRCLE
Three writers on a mission: we offer our e-books, both backlist and new books: and we have opinions about the future of this literature we love.
Closed Circle author: Jane Fancher's Blog, The Captain And Lime
Jane is 1/3 of Closed Circle: writing; covers; e-book conversion; and slideshows
Closed Circle author: Lynn Abbey's Blog, Face of Chaos
Lynn is 1/3 of Closed Circle: writing, web-wizardry, and site-repair
Closed Circle Bazaar: Our Cafe Press Shop
T-shirts, mugs, bags, hats, stickers: you want it, we’ll add the product.
Closed Circle: more information: so what IS a legitimate e-book?
how to keep your favorite writers writing
SEEKING NORTH
a shared world, by Closed Circle authors playing around
The FAQ: What's Closed Circle?
Website: cherryh.com
Website: Jane Fancher
Website: Lynn Abbey
Our Blogroll
Archive Project
Similar to Project Gutenberg: polylingual site: go to Community and select English.
Author sites you should visit: Diane Duane
Diane Duane’s ‘s books and e-books
Author sites you should visit: Jeffrey Carver
Jeffrey Carver’s ebooks and website.
Author sites you should visit: legal free e-books: Project Gutenberg
Project Gutenberg is dedicated to preserving books, classics, including science fiction and fantasy. If it’s old, it may be here.
Author sites you should visit: Patricia Briggs
good friend, good books
Author sites you should visit: Stephen Goldin blog: The Ingesterie
Stephen Goldin also sells lots of e-books.
Calibre: DRM-free books
our books on Calibre’s listing of DRM-free books. Calibre has been with us from the beginning and is a great software, too.
Fantasy Faction
A forum for fantasy readers that allows writers to advertise their work: we have.
Ivan Tefalco: brokencanoe.net , a new writer, has a reciprocal link with us.
New writer
Petfinders: where to ADOPT a Pet
Input your zipcode and find a pet waiting for adoption: in honor of Ruthie
Sacred Band
Janet and Chris Morris: related to Thieves’ World and Heroes in Hell
Spence's Ragi Language link
e-book and notes on Ragi
Where to get: an Avatar
GET AN AVATAR
there is a hard-to-see “signup” link on this page. It’s a pretty fast process, and will follow you to all gravatar enabled sites. DO GET A GRAVATAR BEFORE CREATING YOUR ACCOUNT HERE!
Where to get: e-book free readers
e-book software for Apple products: Stanza
For Apple computers and I-phones, and more: a good reader that handles .epub.
e-book software: Calibre e-book software for Linux
e-book software: Calibre e-book software for Mac: Tiger, Leopard, Snow Leopard, etc.
e-book software: Calibre e-book software for Windows
This is an e-book conversion software and reader. Like most freeware, this hopes for a donation if you turn out to use it. Operates on Windows, OS X (Mac), and Linux.
e-book software: Microsoft Reader Download
Site with download for a reader that reads .lit files...including aloud. Plus a download-able plug-in for MSWord2000 up, that will create .lit files.
e-book software: mobipocket E-book Reader for PC Desktop: Download [box on right]
This turns your PC into an e-book reader for any book in mobi format: works on PC, some phones, eInk devices, blackberry
Archives
Select Month
March 2012
February 2012
January 2012
December 2011
November 2011
October 2011
September 2011
August 2011
July 2011
June 2011
May 2011
April 2011
March 2011
February 2011
January 2011
December 2010
November 2010
October 2010
September 2010
August 2010
July 2010
June 2010
May 2010
April 2010
March 2010
February 2010
January 2010
December 2009
November 2009
October 2009
September 2009
August 2009
July 2009
CONVENTION APPEARANCES Usually at Miscon 2012, around Memorial Day, Missoula MT, CJ/Jane. Also Spokon in Spokane, in July/August,
Radcon 2012, around Feb 14, Red Lion in Pasco Wa, CJ, Jane, OSG. Note:ConDor, San Diego, CA, was a great con, and we may very well go back one day; also on this list, Soonercon, Midsouthcon, Chattacon, and Conquest KC. We are so far behind due to Jane's illness (she is all better now,) not to mention financial hits from same, that we are having to curtail con ac to try to catch up.
December 2011
M
T
W
T
F
S
S
« Nov
Jan »
1234
567891011
12131415161718
19202122232425
262728293031
OSG had surgery today, is doing well... Or as she put it, this is the only scheduled hospital stay she’s ever had...her other visits have involved unplanned ones, aka accidents or emergencies.
She had, and we think it is now entirely past tense, a little rapid-heartbeat problem that she’s had for many years, fixable by surgery if it should become a nuisance, [...]
December 20th, 2011 |
Category: Journal | 18 comments
Meta
Register Log in
Entries RSS
Comments RSS
WordPress.org
Dave's Whizmatronic Widgulating Calibrational Scribometer
next foreigner book
Writing: part of count includes outline, which will be erased as I go.
96,467 of 120,000 words
(80%) complete
PollsPolls ArchiveTagsart
blog
cats
cherryh
closed circle
Closed Circle Bazaar
computer
drm-free
e-book
e-book formats
e-books
ePub
fancher
figure skating
filk
gardening
genealogy
Jane Fancher
koi
lynn abbey
member favorite books
mobi
music
pond
recipes
reef tank
science
science fiction
Spokane
sword & sorcery
the business
the daily grind
twitter
writing
REGISTER! to comment Use the button up in the META section above. Do fill in the NAME blank, be it only a first name, especially if you have a long and random address: our bot-deleter might make an error otherwise.
To get your own avatar as you register, first go to the gravatar site, http://en.gravatar.com/ , get an account, upload your chosen image, and THEN come back here to register. Your gravatar avatar will follow you at all WordPress sites.
Choose a user name that can be pronounced, or it may fail to register. Your first comment will not display until admin (me) vets it, to be sure you are not a lawyer from Hong Kong