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Israe/" + }, + { + "id": 74272, + "strid": "e35deed0-cf68-47d4-84dc-0a77200471e0", + "image_id": 203395, + "image_name": "120146.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 85.117, + 494.275, + 1990.53, + 552.0459999999999 + ], + "priority": 3, + "parents": [ + 74300 + ], + "children": [], + "area": 42071.205175, + "iscrowd": 0, + "segmentation": [], + "text": "SUMMARY: Modeling approaches for algal growth are needed to describe dense illuminated micro-\nalgal cultures, within which the light intensity varies in space through interaction with pigmented cells.\nIn addition to photosynthetic reactions, the motion of cells in the variable light field must be\naccounted for.\n\nAcyclic three-state model (Fig.1, model1) serves as the standard formalism for photosynthesis, in\nwhich a (generic) resting reaction center (O) is first activated (,), and then irreversibly inhibited (4;)\nby photon absorption. The activated reaction center (C) may return to the resting state, after either\nunproductive energy dissipation (k,), or productive energy transduction (k,,); the inhibited reaction\ncenter (f) may also recover to the resting state after a separate repair process (4). A more complex,\nbut realistic, model was also designed with 4 sequential steps (Fig.1, model2) for photon capture." + }, + { + "id": 74273, + "strid": "21dfc8fc-0520-4293-bc67-93a59e7cc16b", + "image_id": 203395, + "image_name": "120146.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2099.391, + 490.318, + 1986.5729999999999, + 557.982 + ], + "priority": 4, + "parents": [ + 74300 + ], + "children": [], + "area": 1029369.196338, + "iscrowd": 0, + "segmentation": [], + "text": "The models were tested on two cases: (i) static illuminated suspension at steady state, (ii) dynamic\nexposure to variable light in a mixed suspension (flashing mode, no steady state,), simulated by\nrandom cell motion. While the former represents a well-defined reference state (approximated at low\ncell density), the latter relates better to real life in a photobioreactor (substantial density).\n\nBoth models in the static mode (Fig.3) were able to reproduce most of the experimentally observed\nbehaviors at moderate to high irradiance/low density; however, as cell density increases they fail to\naccount for critical dynamic aspects of microalgal growth such as its dependence on mixing, and\nabsolute rate reduction at high cell densities.\n\nOnly model2 the more elaborate 4-steps activation model coupled to simulated stochastic motion of\nparticles can satisfactorily mimic experimental results for low irradiance/high density cultures." + }, + { + "id": 74274, + "strid": "23d7a297-f044-46e6-8e7a-1e7dfa672c5c", + "image_id": 203395, + "image_name": "120146.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 82.465, + 1072.248, + 1791.327, + 857.481 + ], + "priority": 5, + "parents": [ + 74300 + ], + "children": [], + "area": 88422.93132, + "iscrowd": 0, + "segmentation": [], + "text": "METHOD: Photosynthesis was modeled as a 3 (mode!1) or 6 (model2) steps cycle as\ndescribed, and the respective steady state solutions for a single reaction center were\nused as static reference states. The kinetic parameters for both models (Fig. 1) were\nadjusted to match routine experimental P-/ curves obtained at low cells density and\nrelatively high incident light intensities.\n\nNext, the modeled RC was put in a more realistic context (locally variable light intensity at\ngiven pigment content and incident light intensity), and the steady states for the active\n\nstate (Css) were recalculated using light intensity either as space-average (C.,.; Fig.2),\nor space-integrated /ocal values of C, (); both values were compared in Fig. 3,\nshowing radical, model-dependent differences at moderate-to-high cells density.\n\nFinally, the random motion of cells in a stirred reactor was simulated by a diffusion-like\nrandom displacement dx at each elementary small time step af, so that (dx)? = 2Ddt. The\nmotion was coupled to the local catalytic reactions (model 1 or 2) at each step, and the\nproduct accumulated (Figs.4-6) . The time increments were recalculated at each step to\nreflect the local changes (e.g., L,), since the rate of catalytic steps vary wildly with light." + }, + { + "id": 74280, + "strid": "05d1dbb4-e2ea-42f8-a6a2-f141c238df3c", + "image_id": 203395, + "image_name": "120146.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3413.54, + 1091.946, + 655.7640000000001, + 48.480999999999995 + ], + "priority": 6, + "parents": [ + 74300 + ], + "children": [ + 74278, + 74275, + 74276, + 74277 + ], + "area": 3727401.3488399996, + "iscrowd": 0, + "segmentation": [], + "text": "Suspension: variable L and" + }, + { + "id": 74275, + "strid": "2004f017-e8f3-438b-b414-1de97dc0f8da", + "image_id": 203395, + "image_name": "120146.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1884.702, + 1076.612, + 1490.227, + 879.299 + ], + "priority": 7, + "parents": [ + 74280 + ], + "children": [], + "area": 2029092.7896240002, + "iscrowd": 0, + "segmentation": [] + }, + { + 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MalQQVOOK OF MICrOdalg\nCulture, 2nd ed. Richmond & Hu, eds. Wiley-Blackwell, pp. 205-22\n\n \n\nThe bottom line\nA research cycle has been completed: the models, instigated by earlier experimental results is mature for further\ncycles of investigation into the intricate coupling of photochemical reaction and motion in a light field\n\nay be reached at density and mixing rate such that Chl. VD = k *« LO" + }, + { + "id": 2552, + "strid": "16a4fc9f-bb1d-4d5a-beda-95e0cc0c1c28", + "image_id": 200605, + "image_name": "10362.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 115, + 70.12, + 353.64, + 239.21999999999997 + ], + "priority": -1, + "parents": [], + "children": [ + 2528, + 2529, + 2530, + 2532, + 2526, + 2531, + 2527, + 2544, + 2543 + ], + "area": 8063.8, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 2544, + "strid": "250ab228-9ca0-41c4-8624-771929e8201c", + "image_id": 200605, + "image_name": "10362.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 607.712, + 43.017, + 2434.512, + 238.829 + ], + "priority": 1, + "parents": [ + 2552 + ], + "children": [], + "area": 26141.947104000003, + "iscrowd": 0, + "segmentation": [], + "text": "Cardiovascular response and serum IL-6 level\nIn concentric and eccentric exercise" + }, + { + "id": 2543, + "strid": "4f918559-156a-404f-a07a-344019aa9f88", + "image_id": 200605, + "image_name": "10362.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 445.925, + 361.455, + 2706.726, + 187.46800000000002 + ], + "priority": 2, + "parents": [ + 2552 + ], + "children": [], + "area": 161181.820875, + "iscrowd": 0, + "segmentation": [], + "text": "Mayank Agarwal’, Prof. Shraddha Singh’, Prof. Sunita Tiwari’, Dr. Jagdish Narayan’, Dr. Shivani Pandey”\n‘Department of Physiology, Department of Biochemistry, King George’s Medical University, Lucknow" + }, + { + "id": 2526, + "strid": "83615ad0-1b9a-4195-a657-af7625122394", + "image_id": 200605, + "image_name": "10362.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 619.539, + 631.253, + 671.922, + 85.46400000000006 + ], + "priority": 3, + "parents": [ + 2552 + ], + "children": [ + 2538, + 2545, + 2539 + ], + "area": 391085.852367, + "iscrowd": 0, + "segmentation": [], + "text": "INTRODUCTION" + }, + { + "id": 2545, + "strid": "3bd989a0-d64a-4835-9036-07945b229adb", + "image_id": 200605, + "image_name": "10362.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 17.061, + 754.367, + 1854.133, + 1237.801 + ], + "priority": 4, + "parents": [ + 2526 + ], + "children": [], + "area": 12870.255387, + "iscrowd": 0, + "segmentation": [], + "text": "Cardiovascular disease (CVD) has been a leading cause of morbidity and\nmortality in India; since 1990, its prevalence has increased by 23%\".\n\nThe higher levels of muscular strength are associated with a significantly\nbetter cardio-metabolic risk factor profile. Hence resistance exercise (RE)\nare strongly recommended for implementation in primary and secondary\nCVD prevention programs. Dynamic RE comprises of concentric (muscle\nshortening contractions) and eccentric (muscle lengthening contractions)\nphase (Fig. 1).\n\nContraction of the skeletal muscles promotes synthesis and secretion of\ncytokines and peptides from myocytes commonly termed as ‘myokines’.\nElevated plasma concentrations of muscle-derived interleukin-6 (IL-6)\npromotes a wide range of benefits in vascular reactivity, lipid and glucose\nmetabolism and the suppression of pro-inflammatory cytokines which may\nreduce the incidence of cardiovascular disease® (Fig. 2).\n\nThe present study aims at determining the cardiovascular response\nand serum IL-6 level in concentric and eccentric exercise." + }, + { + "id": 2538, + "strid": "46a4e540-e4bb-4b72-90d1-cabdf0d0b528", + "image_id": 200605, + "image_name": "10362.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 17.223, + 2175.776, + 666.518, + 873.5830000000001 + ], + "priority": 5, + "parents": [ + 2526 + ], + "children": [ + 2533 + ], + "area": 37473.390047999994, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 2533, + "strid": "86b9d12d-0a18-4cac-b66a-6ccffb7e64fe", + "image_id": 200605, + "image_name": "10362.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 41.781, + 2021.408, + 652.556, + 143.84299999999985 + ], + "priority": 6, + "parents": [ + 2538 + ], + "children": [], + "area": 84456.44764799999, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1: Types of dynamic\nmuscle contraction" + }, + { + "id": 2539, + "strid": "4a351538-2d0a-4771-834c-79bc1be7fd3e", + "image_id": 200605, + "image_name": "10362.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 689.826, + 2171.48, + 1186.758, + 878.8809999999999 + ], + "priority": 7, + "parents": [ + 2526 + ], + "children": [ + 2534 + ], + "area": 1497943.3624800001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 2534, + "strid": "d0c73d7d-684d-4f1a-907d-e87eb0d661ba", + "image_id": 200605, + "image_name": "10362.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 831.163, + 2024.916, + 999.884, + 143.84300000000007 + ], + "priority": 8, + "parents": [ + 2539 + ], + "children": [], + "area": 1683035.257308, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2: Possible effects of IL-6 released\nfrom contracting the skeletal muscle" + }, + { + "id": 2527, + "strid": "b30db25d-366c-4916-8cc3-9f0b4cbeabbf", + "image_id": 200605, + "image_name": "10362.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2549.842, + 634.2, + 383.11299999999983, + 88.41100000000006 + ], + "priority": 9, + "parents": [ + 2552 + ], + "children": [ + 2541, + 2542, + 2546, + 2540 + ], + "area": 1617109.7964, + "iscrowd": 0, + "segmentation": [], + "text": "RESULTS" + }, + { + "id": 2546, + "strid": "356de82f-984c-4bc8-9c1d-0f2a8db8eb78", + "image_id": 200605, + "image_name": "10362.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1922.554, + 756.935, + 1648.6890000000003, + 220.85199999999998 + ], + "priority": 10, + "parents": [ + 2527 + ], + "children": [], + "area": 1455248.41199, + "iscrowd": 0, + "segmentation": [], + "text": "Serum IL-6 level and cardiovascular response to concentric\nexercise (CE) was significantly higher (except DBP) than eccentric\nexercise (EE)." + }, + { + "id": 2542, + "strid": "3950d7f9-364d-4da9-b9f7-725ceba169fe", + "image_id": 200605, + "image_name": "10362.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1946.877, + 1104.022, + 1590.5880000000002, + 910.72 + ], + "priority": 11, + "parents": [ + 2527 + ], + "children": [ + 2535 + ], + "area": 2149395.039294, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 2535, + "strid": "f4ca23d8-6413-4981-84ac-fed75182c09c", + "image_id": 200605, + "image_name": "10362.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1922.265, + 996.965, + 1645.4240000000002, + 84.20099999999991 + ], + "priority": 12, + "parents": [ + 2542 + ], + "children": [], + "area": 1916430.9257250002, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 3: Absolute change in blood pressure in response to CE and EE" + }, + { + "id": 2540, + "strid": "414bef13-fb22-443c-ab95-caafcd9448b4", + "image_id": 200605, + "image_name": "10362.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1931.656, + 2225.297, + 763.5839999999998, + 799.0990000000002 + ], + "priority": 13, + "parents": [ + 2527 + ], + "children": [ + 2537 + ], + "area": 4298508.301832, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 2537, + "strid": "e8a3fdc3-9d95-4df6-97f0-cacf47513b8f", + "image_id": 200605, + "image_name": "10362.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1922.265, + 2070.525, + 652.5559999999998, + 133.3180000000002 + ], + "priority": 14, + "parents": [ + 2540 + ], + "children": [], + "area": 3980097.7391250003, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 4: Absolute change\nin heart rate" + }, + { + "id": 2541, + "strid": "92761c3e-1fcd-464f-91d5-e875b2150c9d", + "image_id": 200605, + "image_name": "10362.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2753.587, + 2240.518, + 806.71, + 786.415 + ], + "priority": 15, + "parents": [ + 2527 + ], + "children": [ + 2536 + ], + "area": 6169461.238066, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 2536, + "strid": "d6f46f5e-05af-49a3-a535-f5c152e2c416", + "image_id": 200605, + "image_name": "10362.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2813.39, + 2081.05, + 673.6060000000002, + 122.79300000000012 + ], + "priority": 16, + "parents": [ + 2541 + ], + "children": [], + "area": 5854805.259500001, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 5: Absolute change\nin serum IL-6 level" + }, + { + "id": 2531, + "strid": "431b5032-aa8a-4274-a99b-5b107cc99d4f", + "image_id": 200605, + "image_name": "10362.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 62.551, + 3121.491, + 1119.87, + 82.51699999999983 + ], + "priority": 17, + "parents": [ + 2552 + ], + "children": [ + 2547 + ], + "area": 195252.38354100002, + "iscrowd": 0, + "segmentation": [], + "text": "MATERIALS AND METHOD" + }, + { + "id": 2547, + "strid": "8b862024-a12b-42f9-8daa-91b8434432b6", + "image_id": 200605, + "image_name": "10362.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 28.448, + 3242.071, + 1185.446, + 1546.799 + ], + "priority": 18, + "parents": [ + 2531 + ], + "children": [], + "area": 92230.435808, + "iscrowd": 0, + "segmentation": [], + "text": "The present non-randomised cross-over study\nwas conducted in the Exercise Physiology\nLaboratory, King George’s Medical University\n(KGMU), Lucknow after approval from the\nInstitutional Ethical Committee.\n\nTwenty-four apparently healthy males, aged 18-\n25 years, having body mass index (BMI) 18-23\nkg/m?,with sedentary lifestyle, voluntary\nparticipated in the study.\n\nAll participants done a session of concentric\nexercise (CE) for 45 minutes, followed by\neccentric exercise (EE) after a rest of 15 days.\n\nExercise was done on inclined (emphasised\nconcentric walk)/ declined (emphasised\neccentric walk) treadmill and with dumbbells.\n\nSystolic blood pressure (SBP), diastolic blood\npressure (DBP), mean arterial pressure (MAP),\npulse pressure (PP), heart rate (HR), and\nserum IL-6 level were measured/calculated just\nbefore and after the exercise sessions." + }, + { + "id": 2530, + "strid": "1ee16e67-17e4-463d-9d84-206d213acc1e", + "image_id": 200605, + "image_name": "10362.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1574.376, + 3115.597, + 580.5640000000001, + 82.51699999999983 + ], + "priority": 19, + "parents": [ + 2552 + ], + "children": [ + 2548 + ], + "area": 4905121.142472, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 2548, + "strid": "d2cfb377-6575-4662-a292-7e789a2fd5f9", + "image_id": 200605, + "image_name": "10362.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1271.086, + 3229.073, + 1164.6489999999997, + 348.355 + ], + "priority": 20, + "parents": [ + 2530 + ], + "children": [], + "area": 4104429.483278, + "iscrowd": 0, + "segmentation": [], + "text": "Based on our present findings, we may\nrecommend eccentric exercise training for\nreducing morbidity and mortality in elderly,\nfrail individuals or those at risk of\ncardiovascular diseases." + }, + { + "id": 2532, + "strid": "bccf8972-182d-4d0c-84f7-59c20c8e46f3", + "image_id": 200605, + "image_name": "10362.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1592.058, + 3651.956, + 536.3589999999999, + 100.19900000000007 + ], + "priority": 21, + "parents": [ + 2552 + ], + "children": [ + 2550 + ], + "area": 5814125.765448, + "iscrowd": 0, + "segmentation": [], + "text": "DISCUSSION" + }, + { + "id": 2550, + "strid": "9b49d50d-55db-4e39-8bc0-eb000c8a3850", + "image_id": 200605, + "image_name": "10362.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1273.686, + 3772.403, + 1146.4509999999998, + 868.2869999999998 + ], + "priority": 22, + "parents": [ + 2532 + ], + "children": [], + "area": 4804856.887457999, + "iscrowd": 0, + "segmentation": [], + "text": "The lesser recruitment and discharge rate of\nmotor units during eccentric contractions\nrelative to concentric contractions* performed\nwith a similar absolute load might be a\npotential explanation for lesser cardiovascular\nresponse to CE as compared to EE.\n\nExercise-induced IL-6 levels majorly depends\non exercise intensity, duration and\ncarbohydrate availability’. EE might have\ncaused less physical exertion resulting in less\nenergy expenditure as compared to CE.\nTherefore, EE induced a lower IL-6 response." + }, + { + "id": 2529, + "strid": "6116d2c4-b75d-40e8-a149-28e965c351e8", + "image_id": 200605, + "image_name": "10362.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2602.888, + 3121.491, + 848.7440000000001, + 76.62300000000005 + ], + "priority": 23, + "parents": [ + 2552 + ], + "children": [ + 2549 + ], + "area": 8124891.466008, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 2549, + "strid": "c1752f7d-3121-4f85-b6e8-6751e5c5df9c", + "image_id": 200605, + "image_name": "10362.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2500.727, + 3239.472, + 1050.2640000000001, + 332.75700000000006 + ], + "priority": 24, + "parents": [ + 2529 + ], + "children": [], + "area": 8101035.096144, + "iscrowd": 0, + "segmentation": [], + "text": "Future studies should involve various\npopulations for comparison, including\nathletes vs. non-athletes, females vs.\nmales and those of differing ages such as\nthe elderly vs. younger populations." + }, + { + "id": 2528, + "strid": "ad2fef36-ce7b-4993-86c0-29922c8d20c7", + "image_id": 200605, + "image_name": "10362.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2747.292, + 3651.956, + 571.723, + 82.51699999999983 + ], + "priority": 25, + "parents": [ + 2552 + ], + "children": [ + 2551 + ], + "area": 10032989.503152, + "iscrowd": 0, + "segmentation": [], + "text": "REFERENCES" + }, + { + "id": 2551, + "strid": "e09a0d3b-f67e-44cb-97bb-263969e0070e", + "image_id": 200605, + "image_name": "10362.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2492.928, + 3764.604, + 1055.4629999999997, + 873.4869999999996 + ], + "priority": 26, + "parents": [ + 2528 + ], + "children": [], + "area": 9384886.720511999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 197370, + "strid": "c3d09bce-f92c-4ebd-93a4-ba3d98b17e91", + "image_id": 208232, + "image_name": "9738.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 0, + 0, + 266.85, + 212.73 + ], + "priority": -1, + "parents": [], + "children": [ + 197354, + 197360, + 197359, + 197356, + 197355, + 197358, + 197357 + ], + "area": 0, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 197354, + "strid": "d35332d8-5e51-448f-990b-f7ff1d39d696", + "image_id": 208232, + "image_name": "9738.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 193.124, + 500.618, + 3136.235, + 162.40799999999996 + ], + "priority": 1, + "parents": [ + 197370 + ], + "children": [], + "area": 96681.350632, + "iscrowd": 0, + "segmentation": [], + "text": "Bibliometria da producao de dissertacoes e teses relacionadas a macrofitas\naquaticas nos ultimos dez anos" + }, + { + "id": 197355, + "strid": "a4c2701c-18c2-4085-b937-dee19f8687ad", + "image_id": 208232, + "image_name": "9738.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 89.231, + 704.33, + 3344.991, + 184.53700000000003 + ], + "priority": 2, + "parents": [ + 197370 + ], + "children": [], + "area": 62848.07023, + "iscrowd": 0, + "segmentation": [], + "text": "Jordano Henrique de Pietro’; Rener Luciano de S. Ferraz?; Joao Teixeira Neto?; Fernanda G. Acre?; Marcelo de A. Barbosa?\n\n1-Discente do Curso Técnico em Meio Ambiente do Senac - SP, Unidade de Jaboticabal, Turma 7; 2- Docentes do Curso Técnico em Meio\nAmbiente do Senac - SP, Unidade de Jaboticabal; 7>- Doutorando em Agronomia (Ciéncia do Solo) UNESP." + }, + { + "id": 197356, + "strid": "3f9e6f23-5462-4aca-8883-9eb91d5994f0", + "image_id": 208232, + "image_name": "9738.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1352.653, + 915.016, + 739.5469999999998, + 112.90199999999993 + ], + "priority": 3, + "parents": [ + 197370 + ], + "children": [ + 197361 + ], + "area": 1237699.137448, + "iscrowd": 0, + "segmentation": [], + "text": "INTRODUCAO" + }, + { + "id": 197361, + "strid": "aa832d26-e644-47ef-b36b-2758bb15bb08", + "image_id": 208232, + "image_name": "9738.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 39.371, + 1066.717, + 3453.735, + 724.154 + ], + "priority": 4, + "parents": [ + 197356 + ], + "children": [], + "area": 41997.715007000006, + "iscrowd": 0, + "segmentation": [], + "text": "Em decorréncia de atividades antropicas, sobretudo aquelas voltadas para os segmentos da industria, tem-se\nverificado, na contemporaneidade, expressivo aumento da poluicao das aguas. De fato, isto tem ocorrido no\nplaneta, principalmente em virtude de perdas ocorridas durante os processos produtivos. Neste sentido, a\ncomunidade cientifica tem buscado alternativas para remediar os danos oriundos destas praticas. Para tanto,\npesquisas estao sendo realizadas utilizando plantas macrofitas aquaticas para remocao dos _poluentes em\nambientes aquaticos, sendo esta estratéegia bastante promissora. A utilizagao de macrofitas aquaticas para\nremediagao da poluigao de ambientes aquaticos @€ uma técnica ecologicamente correta,. simples e\nextremamente sustentavel, sendo seu uso amplamente recomendado, notadamente por possuir baixo custo e\nelevada eficiéncia. objetivou-se com este trabalho realizar um levantamento bibliometrico visando diagnosticar o\ngrau de interesse das instituig¢6es de ensino superior brasileiras sobre o tema macrofitas aquaticas para\nrecuperacao de aguas poluidas." + }, + { + "id": 197357, + "strid": "7febc24c-0d44-44e7-93da-3e7d918c6261", + "image_id": 208232, + "image_name": "9738.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 568.043, + 1832.09, + 817.523, + 74.04899999999998 + ], + "priority": 5, + "parents": [ + 197370 + ], + "children": [ + 197362, + 197363 + ], + "area": 1040705.89987, + "iscrowd": 0, + "segmentation": [], + "text": "\"1 =a\n\nTODOLOGIA" + }, + { + "id": 197362, + "strid": "f0b7f287-1d95-4805-ad6f-1a6691483e55", + "image_id": 208232, + "image_name": "9738.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 40.967, + 1969.255, + 3455.627, + 591.9200000000001 + ], + "priority": 6, + "parents": [ + 197357 + ], + "children": [], + "area": 80674.469585, + "iscrowd": 0, + "segmentation": [], + "text": "Para a o desenvolvimento deste trabalho, realizou-se um levantamento bibliometrico, utilizando-se da Biblioteca\nDigital Brasileira de Teses e Dissertacgoes (BDTD). Para tanto, utilizou-se o campo de busca avancgada do portal,\nacessando-se os campos, resumo, titulo e assunto, sendo inseridas.nestes campos as palavras chave,\nmacrofitas e macrofitas aquaticas. Para o periodo de busca foi definido o critério a partir do ano de defesa,\npreenchendo-se os campos “a partir de” e “até” (Figura 1). Apos obtencgao dos titulos, foi realizada criteriosa\ntriagem para verificagao de ocorréncias de titulos repetidos, sendo estes eliminados do banco de dados quando\ndetectados. As variaveis extraidas dos dados consistiram em, numero de teses e dissertacédes publicadas em\nfuncgao dos anos de defesa, das regides, dos estados e das universidades. Os dados foram submetidos a analise\ndescritiva e os resultados expressos atraves de histogramas de frequéncias." + }, + { + "id": 197363, + "strid": "0ee6f8ec-aabe-4341-9e7c-85e7b1a549cd", + "image_id": 208232, + "image_name": "9738.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 48.776, + 2567.039, + 3415.965, + 406.3539999999998 + ], + "priority": 7, + "parents": [ + 197357 + ], + "children": [ + 197365 + ], + "area": 125209.89426400002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 197365, + "strid": "c332b69f-f911-4740-a6cb-b0b300c2c1fd", + "image_id": 208232, + "image_name": "9738.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 54.691, + 3004.166, + 3437.315, + 55.23700000000008 + ], + "priority": 8, + "parents": [ + 197363 + ], + "children": [], + "area": 164300.84270600002, + "iscrowd": 0, + "segmentation": [], + "text": "Figura 1. Telas obtidas a partir do mecanismo de busca avancada da base online da BDTD. Jaboticabal, SP, 2014." + }, + { + "id": 197358, + "strid": "e0666dd4-2488-492a-85d0-5d3885841339", + "image_id": 208232, + "image_name": "9738.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 619.822, + 3113.864, + 729.103, + 74.50500000000011 + ], + "priority": 9, + "parents": [ + 197370 + ], + "children": [ + 197364, + 197369 + ], + "area": 1930041.412208, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 197369, + "strid": "14965028-6d62-484b-881f-793844857c5a", + "image_id": 208232, + "image_name": "9738.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 39.691, + 3245.666, + 3457.143, + 125.70600000000013 + ], + "priority": 10, + "parents": [ + 197358 + ], + "children": [], + "area": 128823.72920600002, + "iscrowd": 0, + "segmentation": [], + "text": "Verificou-se que maior producao de teses e disserta¢oes ocorreu no ano de 2011 (Figura 1A), na regiao Sudeste\n(Figura 1B), no estado de Sao Paulo (Figura 1C), na Universidade Federal de Sao Carlos (Figura 1D)." + }, + { + "id": 197364, + "strid": "1b64b688-843c-4f6c-8cb5-87a185b99987", + "image_id": 208232, + "image_name": "9738.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 46.988, + 3385.498, + 3465.87, + 496.68100000000004 + ], + "priority": 11, + "parents": [ + 197358 + ], + "children": [ + 197366 + ], + "area": 159077.780024, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 197366, + "strid": "53c58c4e-0c09-4b7d-8b08-e237e7c8c274", + "image_id": 208232, + "image_name": "9738.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 44.019, + 3891.193, + 3449.56, + 55.6550000000002 + ], + "priority": 12, + "parents": [ + 197364 + ], + "children": [], + "area": 171286.424667, + "iscrowd": 0, + "segmentation": [], + "text": "Figura 1..Producao de teses e dissertacoes em funcao do ano de publicacao (A), regiao (B), estado (C) e" + }, + { + "id": 197359, + "strid": "60c9b9f0-d0b6-4852-9c31-f0facb6b1fa4", + "image_id": 208232, + "image_name": "9738.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2519.237, + 4000.06, + 692.6790000000001, + 93.96799999999985 + ], + "priority": 13, + "parents": [ + 197370 + ], + "children": [ + 197367 + ], + "area": 10077099.15422, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 197367, + "strid": "828b2855-0246-48f6-a83f-8195a8fb6e79", + "image_id": 208232, + "image_name": "9738.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 52.522, + 4158.911, + 3454.702, + 190.09599999999955 + ], + "priority": 14, + "parents": [ + 197359 + ], + "children": [], + "area": 218434.323542, + "iscrowd": 0, + "segmentation": [], + "text": "Com base na analise bibliometrica, conclui-se que as institui¢c¢oes de ensino superior brasileiras possuem\ninteresse sobre o tema macrofitas aquaticas para recuperacao de aguas poluidas, sobretudo no estado de Sao\nPaulo, na regiao Sudeste, tendo a maior frequéncia de producoées bibliograficas ocorrido no ano de 2011." + }, + { + "id": 197360, + "strid": "56a14e36-b2a8-4340-922d-35006aa378ed", + "image_id": 208232, + "image_name": "9738.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1197.102, + 4388.848, + 1047.573, + 75.2510000000002 + ], + "priority": 15, + "parents": [ + 197370 + ], + "children": [ + 197368 + ], + "area": 5253898.718496, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 197368, + "strid": "bf233e3c-3d28-47b1-8dca-d0ddd3022d2b", + "image_id": 208232, + "image_name": "9738.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 49.524, + 4531.849, + 2749.749, + 54.952000000000226 + ], + "priority": 16, + "parents": [ + 197360 + ], + "children": [], + "area": 224435.28987600002, + "iscrowd": 0, + "segmentation": [], + "text": "Ao Servico Nacional de Aprendizagem Comercial e ao Grupo de Pesquisa Agroecoenergia." + }, + { + "id": 151214, + "strid": "3ebfbb3f-fa47-4576-8792-54b37bf4b383", + "image_id": 206381, + "image_name": "21277.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 2636.69, + 211.22, + 356.6199999999999, + 277.36 + ], + "priority": -1, + "parents": [], + "children": [ + 151198, + 151211, + 151213, + 151212, + 151200, + 151197, + 151201 + ], + "area": 556921.6618, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 151198, + "strid": "fc72ff78-e6b2-4608-bb02-6f15245389cb", + "image_id": 206381, + "image_name": "21277.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 82.521, + 537.3, + 2420.807, + 254.606 + ], + "priority": 1, + "parents": [ + 151214 + ], + "children": [], + "area": 44338.533299999996, + "iscrowd": 0, + "segmentation": [], + "text": "Comparison of Deconvolution Techniques\nfor Spatially Resolved Transcriptomics Data" + }, + { + "id": 151197, + "strid": "3dc9a539-f5de-4a62-ad1c-bd30ca351f5c", + "image_id": 206381, + "image_name": "21277.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 64.616, + 113.596, + 2412.019, + 362.106 + ], + "priority": 2, + "parents": [ + 151214 + ], + "children": [], + "area": 7340.119136, + "iscrowd": 0, + "segmentation": [], + "text": "Carolin Walter *, Sarah Sandmann *, Ada Anike PohImann *, Alina Sophie\nDisch *, Kornelius Kerl *, and Julian Varghese *\n\n“Institute of Medical Informatics, University of Munster, Germany\n*Dep. of Paediatric Haematology and Oncology, University of Munster, Germany" + }, + { + "id": 151200, + "strid": "a861956d-1dbc-489d-9fde-bcaefc2f2295", + "image_id": 206381, + "image_name": "21277.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 123.684, + 880.881, + 613.537, + 92.88599999999997 + ], + "priority": 3, + "parents": [ + 151214 + ], + "children": [ + 151199 + ], + "area": 108950.885604, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 151199, + "strid": "4236b639-89f9-4abf-bd9c-dc9786dbfa07", + "image_id": 206381, + "image_name": "21277.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 116.351, + 990.877, + 1488.621, + 862.863 + ], + "priority": 4, + "parents": [ + 151200 + ], + "children": [], + "area": 115289.52982699999, + "iscrowd": 0, + "segmentation": [], + "text": "Spatially Resolved Transcriptomics (ST) is a\nmolecular profiling technique that allows insight\ninto tumor heterogeneity and the composition of\ntumor microenvironment data [1]. Current ST\ntechniques typically provide a multi-cell resolution\nwith cell mixtures for small spatial areas (‘spots’).\nComputational deconvolution methods can then be\nemployed to approximate the expression and type\nof the involved cells per spot. While the algorithms\nSTdeconvolve (SD) [2] and SPOTlight (SL) [3] offer\nfunctions for spot-wise ST deconvolution, the Seurat\n[4] pipeline uses an integration approach (SI) to\npredict the cell composition for each ST spot." + }, + { + "id": 151201, + "strid": "505d628d-5894-4312-9731-4328c3b429d2", + "image_id": 206381, + "image_name": "21277.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 121.24, + 1914.849, + 435.09799999999996, + 105.10799999999995 + ], + "priority": 5, + "parents": [ + 151214 + ], + "children": [ + 151205, + 151206 + ], + "area": 232156.29275999998, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 151205, + "strid": "8542c430-8a5f-4dbb-a82b-99eb13bfd535", + "image_id": 206381, + "image_name": "21277.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 122.563, + 2028.405, + 1487.922, + 603.6859999999999 + ], + "priority": 6, + "parents": [ + 151201 + ], + "children": [], + "area": 248607.402015, + "iscrowd": 0, + "segmentation": [], + "text": "Three computational deconvolution and integration\nalgorithms for ST data were compared on a set of\neight original human 10X Visium retinoblastoma\nSamples (Figure 1). Matched single-cell RNA-seq\n(ScCRNA) data with detailed annotations was\navailable as reference dataset. Deconvolutions for\ndifferent topic numbers and levels of details for the\nreference annotation were created and the run time\nof the algorithms was tested with basic R functions." + }, + { + "id": 151206, + "strid": "59896358-4e04-4794-a76f-2016631674cc", + "image_id": 206381, + "image_name": "21277.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 102.523, + 2634.595, + 1502.952, + 608.6950000000002 + ], + "priority": 7, + "parents": [ + 151201 + ], + "children": [ + 151207 + ], + "area": 270106.583185, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 151207, + "strid": "6c1a74b2-bcfe-49f9-ba55-bc2f04d4e890", + "image_id": 206381, + "image_name": "21277.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 120.058, + 3255.816, + 1495.437, + 170.33399999999983 + ], + "priority": 8, + "parents": [ + 151206 + ], + "children": [], + "area": 390886.757328, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1: Analysis workflow. After a preprocessing step with\nSpaceRanger 1.3.0, spot-wise deconvolutions were calculated for\nthe ST data and annotated based on the matched scRNA data." + }, + { + "id": 151213, + "strid": "32742b30-232d-4694-b5f8-8181bd96a50c", + "image_id": 206381, + "image_name": "21277.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 125.068, + 3493.783, + 360.708, + 87.67200000000003 + ], + "priority": 9, + "parents": [ + 151214 + ], + "children": [ + 151204, + 151202, + 151208 + ], + "area": 436960.452244, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 151208, + "strid": "7213763c-7e9b-4216-982e-8458a39b0490", + "image_id": 206381, + "image_name": "21277.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 125.068, + 3596.485, + 1480.407, + 603.6860000000001 + ], + "priority": 10, + "parents": [ + 151213 + ], + "children": [], + "area": 449805.18598, + "iscrowd": 0, + "segmentation": [], + "text": "The Seurat integration approach and SPOTlight both\nindicated a high proportion of tumor cells (general\ntumor or tumor cones) in most of the ST clusters.\nFor most STdeconvolve cell types, correlation\nresults were high for the different tumor types as\nwell. The Seurat integration indicated a notable\npresence of glia cells in clusters 1 and 6, and\nbipolar cells in cluster 6 (Figure 2), which matched\nthe marker-based expert annotation of the dataset." + }, + { + "id": 151202, + "strid": "d7de070e-afea-451f-a8a4-41c55ba4a559", + "image_id": 206381, + "image_name": "21277.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1656.304, + 846.659, + 1515.5100000000002, + 857.974 + ], + "priority": 11, + "parents": [ + 151213 + ], + "children": [ + 151203 + ], + "area": 1402324.688336, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 151203, + "strid": "a580cb48-441a-48da-bb1b-52ec67a96c61", + "image_id": 206381, + "image_name": "21277.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1666.082, + 1711.966, + 1500.843, + 153.9949999999999 + ], + "priority": 12, + "parents": [ + 151202 + ], + "children": [], + "area": 2852275.737212, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2: Deconvolution results per ST cluster. a) Seurat\nintegration (prediction scores), b) SPOTlight (deconvolution\nmatrix), c) STdeconvolve (correlation to reference cell types)." + }, + { + "id": 151204, + "strid": "53b91410-0dfa-4351-b02c-143191cc7e6a", + "image_id": 206381, + "image_name": "21277.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1665.593, + 1880.615, + 1530.506, + 676.3280000000002 + ], + "priority": 13, + "parents": [ + 151213 + ], + "children": [], + "area": 3132339.179695, + "iscrowd": 0, + "segmentation": [], + "text": "In contrast, SPOTlight mainly identified tumor cells\nand B cells in the dataset. STdeconvolve's cell types\nusually showed correlations of 0.5 or higher with\nmultiple reference cell types, with a general trend for\nhigh tumor and tumor cones proportions, and bipolar\ncells. This pattern was similar for all eight samples.\n\nMedian run times in minutes were comparable\nbetween algorithms (SL=6.06, SI=8.76, SD=13.8). All\nthree algorithms are integrated in the R/Bioconductor\nenvironment and include detailled documentation." + }, + { + "id": 151212, + "strid": "879dce14-0b4a-438e-a08c-1d2a0507f6d4", + "image_id": 206381, + "image_name": "21277.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1660.583, + 2642.11, + 1224.906, + 92.68199999999979 + ], + "priority": 14, + "parents": [ + 151214 + ], + "children": [ + 151209 + ], + "area": 4387442.950130001, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion & Conclusion" + }, + { + "id": 151209, + "strid": "5c1a92a5-09ba-4fec-aebe-aab6113e9bca", + "image_id": 206381, + "image_name": "21277.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1660.583, + 2747.317, + 1540.525, + 748.971 + ], + "priority": 15, + "parents": [ + 151212 + ], + "children": [], + "area": 4562147.905811001, + "iscrowd": 0, + "segmentation": [], + "text": "Deconvoluted cell types and marker-based annotation\nof ST clusters by domain experts varied depending on\nthe cell proportions and composition of the underlying\ntissue, with higher concordance for transcriptionally\ndistinct cell types, and cell types with a _ high\nfrequency in both ST and scRNA data. The Seurat\nintegration generally yielded the most accurate\nresults for the eight retinoblastoma samples. Further\nresearch is required to achieve more consistent and\nreliable results for less frequent or more similar cell\ntypes; an improved resolution of ST data is desirable." + }, + { + "id": 151211, + "strid": "4f9040b4-4815-4b2d-9b9f-69b3bd0c8226", + "image_id": 206381, + "image_name": "21277.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1668.098, + 3566.425, + 566.1120000000001, + 105.20699999999988 + ], + "priority": 16, + "parents": [ + 151214 + ], + "children": [ + 151210 + ], + "area": 5949146.40965, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 151210, + "strid": "5824ffb1-2d9e-4161-bf15-8d53c908a6d7", + "image_id": 206381, + "image_name": "21277.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1660.583, + 3679.147, + 1538.0210000000002, + 511.0039999999999 + ], + "priority": 17, + "parents": [ + 151211 + ], + "children": [], + "area": 6109528.962701, + "iscrowd": 0, + "segmentation": [], + "text": "[1] Ahmed R et al. Single-Cell RNA Sequencing with Spatial\nTranscriptomics of Cancer Tissues. Int J Mol Sci. (2022). [2] Miller B\net al. Reference-free cell type deconvolution of multi-cellular pixel-\nresolution spatially resolved transcriptomics data. Nat. Commun.\n(2022). [3] Elosua-Bayes M et al. SPOTlight: seeded NMF regression\nto deconvolute spatial transcriptomics spots with single-cell\ntranscriptomes. Nucleic Acids Res. (2021). [4] Hao et al. Integrated\nanalysis of multimodal single-cell data. Cell (2021)." + }, + { + "id": 97274, + "strid": "dda94b02-4bc4-40c8-bb21-c83b0bf87231", + "image_id": 204262, + "image_name": "121745.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 47.06, + 78.85, + 143.42, + 209.6 + ], + "priority": -1, + "parents": [], + "children": [ + 97259, + 97258, + 97262, + 97264, + 97260, + 97261, + 97257, + 97263 + ], + "area": 3710.681, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 97257, + "strid": "69b9fbdf-8d44-4cb8-b19e-a3c0014a6285", + "image_id": 204262, + "image_name": "121745.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 298.543, + 95.039, + 2297.667, + 233.051 + ], + "priority": 1, + "parents": [ + 97274 + ], + "children": [], + "area": 28373.228177, + "iscrowd": 0, + "segmentation": [], + "text": "First approach to the identification of clinically relevant non tuberculous\nmycobacteria (NTM) from solid media by matrix-assisted laser\ndesorption/ionization spectrometry (MALDI-TOF MS) protein analysis" + }, + { + "id": 97258, + "strid": "cac60cee-e20b-42c1-86ea-97faca9dcefe", + "image_id": 204262, + "image_name": "121745.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 283.89, + 350.34, + 2333.487, + 107.08800000000002 + ], + "priority": 2, + "parents": [ + 97274 + ], + "children": [], + "area": 99458.02259999998, + "iscrowd": 0, + "segmentation": [], + "text": "M. B. Orlandoni', R. Paul’, J. Monteserin', G. Lafuente’, V. Ritacco'?, B. Lopez!\nTINEI-ANLIS Dr. C. Malbran, Vélez Sarsfield 563; 2CONICET, Buenos Aires, Argentina. Email: borlandoni@anlis.gov.ar" + }, + { + "id": 97259, + "strid": "0d030c63-6723-46a5-9daa-cf6aaf161d2e", + "image_id": 204262, + "image_name": "121745.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 166.979, + 518.945, + 325.278, + 48.09000000000003 + ], + "priority": 3, + "parents": [ + 97274 + ], + "children": [ + 97270 + ], + "area": 86652.91715500002, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 97270, + "strid": "eb6cf6ec-ce8a-4219-9142-a767fb8faf3e", + "image_id": 204262, + "image_name": "121745.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 162.357, + 604.561, + 2833.233, + 264.57499999999993 + ], + "priority": 4, + "parents": [ + 97259 + ], + "children": [], + "area": 98154.710277, + "iscrowd": 0, + "segmentation": [], + "text": "NTM comprise a large group of environmental organisms, many of which are opportunistic human pathogens. Species identification of acid- fast\nbacilli isolated from clinical specimens continues posing a challenge to diagnostic laboratories. Recently, the widespread implementation of\nMALDI-TOF MS in different health care settings has allowed reduction of turnaround time and cost of bacterial identification [1]. As a national\nreference centre for infectious diseases, our institute counts with a MALDI-TOF equipment which is being applied to identification of other\nmicrobial pathogens. However, there is less experience in its use for the speciation of mycobacteria [2]." + }, + { + "id": 97260, + "strid": "a04d1dc0-4e18-42ad-8dcb-f8e043fbfcfb", + "image_id": 204262, + "image_name": "121745.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 150.477, + 897.511, + 251.80299999999997, + 57.92700000000002 + ], + "priority": 5, + "parents": [ + 97274 + ], + "children": [ + 97271 + ], + "area": 135054.762747, + "iscrowd": 0, + "segmentation": [], + "text": "Objective" + }, + { + "id": 97271, + "strid": "9f65b25d-1346-4ed9-ac18-7e1a8a7d1a77", + "image_id": 204262, + "image_name": "121745.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 147.541, + 980.12, + 1884.263, + 47.071000000000026 + ], + "priority": 6, + "parents": [ + 97260 + ], + "children": [], + "area": 144607.88492, + "iscrowd": 0, + "segmentation": [], + "text": "To evaluate MALDI-TOF MS protein analysis for identification of clinically relevant NTM species." + }, + { + "id": 97261, + "strid": "7f80026b-fe6d-4af6-91e5-f33f99df5093", + "image_id": 204262, + "image_name": "121745.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 175.94, + 1084.631, + 227.44, + 45.858999999999924 + ], + "priority": 7, + "parents": [ + 97274 + ], + "children": [ + 97266, + 97272 + ], + "area": 190829.97814000002, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 97272, + "strid": "5fa6de45-31bb-41d4-b6e2-7e3d1788c414", + "image_id": 204262, + "image_name": "121745.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 170.484, + 1173.002, + 1519.485, + 691.0900000000001 + ], + "priority": 8, + "parents": [ + 97261 + ], + "children": [], + "area": 199978.072968, + "iscrowd": 0, + "segmentation": [], + "text": "We selected 57 clinical isolates from our diagnostic routine (47 from patients\nwith proven mycobacteriosis). The isolates had been unambiguously identified\nby phenotypic tests and PRA-hsp65 as belonging to 13 NTM species. We\nre-cultured the bacilli on the L6wenstein—Jensen slants routinely used in our\nlab instead of doing it on the costly 7H11 Middlebrook agar suggested by the\nmanufacturers. We extracted proteins according to Saleeb et al. [3], with\nminor modifications. We spotted duplicate samples onto a steel target plate\nin the MALDI Biotyper system, Bruker Daltonics. Each spot was measured\nusing 240 laser shots. Spectra were analyzed against the Bruker database\nv1. According to the manufacturers, optimal identification to the species-level\nis achieved with scores 1.7 to 22.0 while scores <1.7 are considered\nunreliable. The whole MALDI-TOF procedure, including reading of results,\nwas completed in one working day." + }, + { + "id": 97266, + "strid": "5bb8ab63-e8e7-490f-a87d-bf8a8c0e00c9", + "image_id": 204262, + "image_name": "121745.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1755.985, + 1100.433, + 1284.961, + 751.038 + ], + "priority": 9, + "parents": [ + 97261 + ], + "children": [], + "area": 1932343.841505, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 97262, + "strid": "44c9709e-9198-44cb-b08b-c4c7f0f48894", + "image_id": 204262, + "image_name": "121745.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 184.21, + 1937.388, + 197.49000000000004, + 45.863000000000056 + ], + "priority": 10, + "parents": [ + 97274 + ], + "children": [ + 97265, + 97267, + 97273 + ], + "area": 356886.24348, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 97273, + "strid": "0065d7c0-927e-4930-ba3c-ce83ff650865", + "image_id": 204262, + "image_name": "121745.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 179.952, + 2027.054, + 2806.557, + 261.73099999999977 + ], + "priority": 11, + "parents": [ + 97262 + ], + "children": [], + "area": 364772.421408, + "iscrowd": 0, + "segmentation": [], + "text": "MALDI-TOF MS identified 49/57 (86%) isolates to the species level with different degrees of certitude: 41/49 (84%) yielded scores >1.7 and\n8/49 (14%) scores <1.7. Of the 8 isolates which remained unidentified, 4 belong to species represented by only one spectrum in the Bruker\ndatabase. Seeking to improve accuracy, we assessed different extraction conditions in parallel experiments using 8 isolates from different\nNTM species. The best condition included 0.5% tween 80 and 100% formic acid. This modified protocol yielded higher scores with extracts\nobtained from Lowenstein-Jensen medium, thus allowing better NTM identification without compromising budget or routine lab workflow." + }, + { + "id": 97265, + "strid": "83eff33a-cc1e-44a2-8ef7-2fc8eb2c26fd", + "image_id": 204262, + "image_name": "121745.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 170.599, + 2375.424, + 1403.96, + 762.1089999999999 + ], + "priority": 12, + "parents": [ + 97262 + ], + "children": [], + "area": 405244.95897599997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 97267, + "strid": "37658b50-2c76-4231-b848-a9fbe5f726ce", + "image_id": 204262, + "image_name": "121745.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1725.328, + 2401.441, + 1129.335, + 757.8069999999998 + ], + "priority": 13, + "parents": [ + 97262 + ], + "children": [], + "area": 4143273.3976479997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 97263, + "strid": "0202ccf8-1af7-4c5c-81c5-9094a8aa68a7", + "image_id": 204262, + "image_name": "121745.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 166.371, + 3258.637, + 286.51700000000005, + 48.20199999999977 + ], + "priority": 14, + "parents": [ + 97274 + ], + "children": [ + 97268 + ], + "area": 542142.696327, + "iscrowd": 0, + "segmentation": [], + "text": "Comments" + }, + { + "id": 97268, + "strid": "71205f31-7de2-4964-8fbe-c5c19bef6416", + "image_id": 204262, + "image_name": "121745.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 164.454, + 3350.264, + 2822.847, + 201.29399999999987 + ], + "priority": 15, + "parents": [ + 97263 + ], + "children": [], + "area": 550964.3158560001, + "iscrowd": 0, + "segmentation": [], + "text": "MALDI-TOF MS shows promise as a powerful tool for simple and inexpensive identification of clinically relevant NTM. We find the Bruker\ndatabase still deficient regarding both number of NTM species represented and number of spectra per NTM species. To maximize the accuracy\nof the method, we are currently evaluating our improved version of the extraction protocol and building a customized NTM database using\n\nmanufacturer-recommended criteria." + }, + { + "id": 97264, + "strid": "583429ae-b7ca-4a67-957a-18725eb9ab7f", + "image_id": 204262, + "image_name": "121745.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 167.924, + 3596.915, + 236.903, + 38.19200000000001 + ], + "priority": 16, + "parents": [ + 97274 + ], + "children": [ + 97269 + ], + "area": 604008.3544600001, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 97269, + "strid": "7f2fc8c4-36f8-4d1c-9a17-749dfec79890", + "image_id": 204262, + "image_name": "121745.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 165.373, + 3646.506, + 2819.25, + 238.69000000000005 + ], + "priority": 17, + "parents": [ + 97264 + ], + "children": [], + "area": 603033.636738, + "iscrowd": 0, + "segmentation": [], + "text": "Clark AE, Kaleta EJ, Arora A, Wolk DM. Matrix-assisted laser desorption ionization-time of flight mass spectrometry: a fundamental shift in the routine practice of clinical microbiology. Clin\nMicrobiol Rev. 2013 Jul;26(3):547-603.\n\nMather CA, Rivera SF, Butler-Wu SM. Comparison of the Bruker Biotyper and Vitek MS matrix-assisted laser desorption ionization-time of flight mass spectrometry systems for identification\nof mycobacteria using simplified protein extraction protocols. J Clin Microbiol. 2014 Jan;52(1):130-8.\n\nSaleeb PG1, Drake SK, Murray PR, Zelazny AM. Identification of mycobacteria in solid-culture media by matrix-assisted laser desorption ionization-time of flight mass spectrometry. 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the original quality scores. However,\nBQSR normally requires a reference genome and a database of variable sites. Our reference-free\nmethod uses a method similar to the lighter (Song, Florea, and Langmead 2014) error corrector to find\nerroneous bases rather than comparing the sequence to a reference. You can use your favorite error corrector\nand use those corrections as input to kbbq." + }, + { + "id": 135625, + "strid": "ccb585fd-8f38-4c63-af3b-f96b3b130ad9", + "image_id": 205757, + "image_name": "15862.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 273.567, + 1476.727, + 775.4259999999999, + 46.82899999999995 + ], + "priority": 8, + "parents": [ + 135607 + ], + "children": [], + "area": 403983.77520900004, + "iscrowd": 0, + "segmentation": [], + "text": "GATK BQSR - Reference Required" + }, + { + "id": 135618, + "strid": "6586cb13-490e-4fac-9566-1b95a66f95a4", + "image_id": 205757, + "image_name": "15862.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 74.564, + 1544.873, + 1175.278, + 371.70900000000006 + ], + "priority": 9, + "parents": [ + 135607 + ], + "children": [], + "area": 115191.910372, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 135626, + "strid": "648c0158-98b2-43f3-ae06-f29b0ae6e5a0", + "image_id": 205757, + "image_name": "15862.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1525.542, + 1476.727, + 487.568, + 45.45100000000002 + ], + "priority": 10, + "parents": [ + 135607 + ], + "children": [], + "area": 2252809.061034, + "iscrowd": 0, + "segmentation": [], + "text": "Reference Free BQSR" + }, + { + "id": 135619, + "strid": "e3069419-5085-403b-af8d-8b05c664e81f", + "image_id": 205757, + "image_name": "15862.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1397.909, + 1543.331, + 740.3330000000001, + 371.70900000000006 + ], + "priority": 11, + "parents": [ + 135607 + ], + "children": [], + "area": 2157436.294879, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 135612, + "strid": "e7f0f6a3-262e-423c-a22a-67dd3c5a5a52", + "image_id": 205757, + "image_name": "15862.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 63.193, + 2006.668, + 804.073, + 49.30599999999981 + ], + "priority": 12, + "parents": [ + 135630 + ], + "children": [ + 135623, + 135624, + 135620, + 135614 + ], + "area": 126807.37092399999, + "iscrowd": 0, + "segmentation": [], + "text": "Methods: Hierarchical Linear Model" + }, + { + "id": 135623, + "strid": "1fb4ab52-6ecf-41a4-8555-47ffda1bffd3", + "image_id": 205757, + "image_name": "15862.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 44.361, + 2163.619, + 1193.214, + 276.19399999999996 + ], + "priority": 13, + "parents": [ + 135612 + ], + "children": [], + "area": 95980.302459, + "iscrowd": 0, + "segmentation": [], + "text": "The recalibration uses a hierarchical linear model to predict the\ntrue probability of error given a set of covariates. Each\ncovariate causes the predicted quality score to shift up or down\nfrom the predicted score one level above it in the hierarchy.\nThe relevant covariates are:" + }, + { + "id": 135614, + "strid": "e5d4d64d-dc0b-46a9-8d8a-a0ceab0f47c6", + "image_id": 205757, + "image_name": "15862.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 74.22, + 2459.627, + 1098.519, + 298.62699999999995 + ], + "priority": 14, + "parents": [ + 135612 + ], + "children": [], + "area": 182553.51593999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 135624, + "strid": "bee5c1d1-2764-4e26-8710-eb46cc4dbdae", + "image_id": 205757, + "image_name": "15862.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1447.101, + 2129.604, + 570.076, + 40.81700000000001 + ], + "priority": 15, + "parents": [ + 135612 + ], + "children": [], + "area": 3081752.078004, + "iscrowd": 0, + "segmentation": [], + "text": "Hierarchical Linear Model" + }, + { + "id": 135620, + "strid": "10a5f993-a03f-4f78-8e1d-73c68755468c", + "image_id": 205757, + "image_name": "15862.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1410.917, + 2169.641, + 644.9099999999999, + 638.248 + ], + "priority": 16, + "parents": [ + 135612 + ], + "children": [], + "area": 3061183.370797, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 135611, + "strid": "49b77396-6618-4fdc-92a4-bc17dd454aed", + "image_id": 205757, + "image_name": "15862.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 64.457, + 2873.954, + 463.985, + 45.514000000000124 + ], + "priority": 17, + "parents": [ + 135630 + ], + "children": [ + 135615 + ], + "area": 185246.452978, + "iscrowd": 0, + "segmentation": [], + "text": "Methods:" + }, + { + "id": 135615, + "strid": "fd975c72-c291-470a-88b6-db3651a68484", + "image_id": 205757, + "image_name": "15862.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 51.365, + 2982.223, + 2114.764, + 231.5880000000002 + ], + "priority": 18, + "parents": [ + 135611 + ], + "children": [], + "area": 153181.884395, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 135610, + "strid": "0a11f867-b945-46b0-814d-5ba335686b82", + "image_id": 205757, + "image_name": "15862.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 64.457, + 3291.161, + 247.796, + 49.30600000000004 + ], + "priority": 19, + "parents": [ + 135630 + ], + "children": [ + 135616 + ], + "area": 212138.36457699997, + "iscrowd": 0, + "segmentation": [], + "text": "Next Steps" + }, + { + "id": 135616, + "strid": "f940cda5-39c8-42d4-9fd5-90fc48dafacd", + "image_id": 205757, + "image_name": "15862.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 52.889, + 3407.309, + 1404.764, + 179.78499999999985 + ], + "priority": 20, + "parents": [ + 135610 + ], + "children": [], + "area": 180209.16570100002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 135608, + "strid": "0a4b4218-e4c8-492c-a79f-5136910033c2", + "image_id": 205757, + "image_name": "15862.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2254.297, + 467.43, + 1743.3430000000003, + 49.93599999999998 + ], + "priority": 21, + "parents": [ + 135630 + ], + "children": [ + 135622 + ], + "area": 1053726.0467100001, + "iscrowd": 0, + "segmentation": [], + "text": "Results: GATK BQSR is vulnerable to false negatives in the known sites input." + }, + { + "id": 135622, + "strid": "adb89a8e-ca27-4e69-a9ce-51d116830d3f", + "image_id": 205757, + "image_name": "15862.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2231.193, + 568.375, + 2094.8769999999995, + 1665.239 + ], + "priority": 22, + "parents": [ + 135608 + ], + "children": [ + 135627 + ], + "area": 1268154.321375, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 135627, + "strid": "1b6752c9-b4d9-4b0e-97f7-c9908251c2f3", + "image_id": 205757, + "image_name": "15862.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2224.676, + 2263.859, + 2078.8489999999997, + 52.702999999999975 + ], + "priority": 23, + "parents": [ + 135622 + ], + "children": [], + "area": 5036352.784684, + "iscrowd": 0, + "segmentation": [], + "text": "KBBQ doesn't require a priori knowledge of variable sites, so is unaffected by misspecification of known sites." + }, + { + "id": 135609, + "strid": "ce973dad-cac4-4e9e-91b7-894c1c46d38d", + "image_id": 205757, + "image_name": "15862.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2253.002, + 2386.24, + 1388.649, + 53.52399999999989 + ], + "priority": 24, + "parents": [ + 135630 + ], + "children": [ + 135621 + ], + "area": 5376203.49248, + "iscrowd": 0, + "segmentation": [], + "text": "Results: Similar performance, no reference or variants required" + }, + { + "id": 135621, + "strid": "f81445b9-0a5d-4688-a0a3-d8514e3bef53", + "image_id": 205757, + "image_name": "15862.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2282.102, + 2487.538, + 1985.5119999999997, + 1668.038 + ], + "priority": 25, + "parents": [ + 135609 + ], + "children": [ + 135628 + ], + "area": 5676815.444875999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 135628, + "strid": "7ca0f71c-e7b5-49fd-8969-579e6e1dcf05", + "image_id": 205757, + "image_name": "15862.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2226.628, + 4182.646, + 1793.862, + 56.60699999999997 + ], + "priority": 26, + "parents": [ + 135621 + ], + "children": [], + "area": 9313196.697688, + "iscrowd": 0, + "segmentation": [], + "text": "Both methods improve calibration and resolution, while KBBQ has relaxed input requirements." + }, + { + "id": 190145, + "strid": "fc87dded-4dbf-4ed3-94d0-90164e7e4704", + "image_id": 207919, + "image_name": "9118.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 62.81, + 96.24, + 196.58999999999997, + 218.43 + ], + "priority": -1, + "parents": [], + "children": [ + 190117, + 190118, + 190135, + 190114, + 190116, + 190115, + 190136 + ], + "area": 6044.8344, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190114, + "strid": "a880c669-2252-468b-975e-463bda378731", + "image_id": 207919, + "image_name": "9118.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 385.651, + 123.261, + 2768.09, + 220.93799999999996 + ], + "priority": 1, + "parents": [ + 190145 + ], + "children": [], + "area": 47535.727911, + "iscrowd": 0, + "segmentation": [], + "text": "Contrasting approaches to predicting ADPKD progression\nand outcomes" + }, + { + "id": 190115, + "strid": "cb74d5ec-dceb-451a-8d94-b2fdd4c2b08d", + "image_id": 207919, + "image_name": "9118.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 707.914, + 424.69, + 2125.6040000000003, + 224.66300000000007 + ], + "priority": 2, + "parents": [ + 190145 + ], + "children": [], + "area": 300643.99666, + "iscrowd": 0, + "segmentation": [], + "text": "O’Reilly R', McEwan P2*%, Bennett H?, Robinson R'\n\n1 Otsuka Pharmaceutical Europe Ltd, Wexham, UK; ?Health Economics & Outcomes Research Ltd, Monmouth, UK;\n3 School of Human & Health Sciences, Swansea University, Swansea, UK" + }, + { + "id": 190116, + "strid": "f98ddfa3-46ac-4cb4-9a6c-79dc1b425887", + "image_id": 207919, + "image_name": "9118.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 117.504, + 963.074, + 682.204, + 50.823999999999955 + ], + "priority": 3, + "parents": [ + 190145 + ], + "children": [ + 190128 + ], + "area": 113165.047296, + "iscrowd": 0, + "segmentation": [], + "text": "NTRODUCTION AND AIMS" + }, + { + "id": 190128, + "strid": "40f6e378-ae8e-48b0-a184-33a1a3adcce1", + "image_id": 207919, + "image_name": "9118.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 117.257, + 1077.482, + 1054.279, + 1736.672 + ], + "priority": 4, + "parents": [ + 190116 + ], + "children": [], + "area": 126342.306874, + "iscrowd": 0, + "segmentation": [], + "text": "Autosomal dominant polycystic kidney disease (ADPKD) is a\nmajor cause of end-stage renal disease (ESRD) [1],\ncharacterised by progressive development of kidney cysts\nleading to complications such as pain, haematuria and\nhypertension, and declining renal function.\n\nGiven the heterogeneous nature of progression, an\nunderstanding of a patient’s risk of, and likely rate of\nprogression towards, ESRD is important to inform treatment\ndecisions.\n\nRates of ADPKD progression are linked to factors such as\nage, gender, genetic mutation and hypertension, in addition\nto total kidney volume (TKV) [2,3].\n\nThe imaging classification of ADPKD was developed from\nMayo clinic observations to inform patient selection for\nClinical trial inclusion; risk of renal progression is stratified by\ncyst distribution, age and height-adjusted TKV (classes\n1A-E, 2A-B) [4]. The Mayo classification may be used to\npredict future eGFR for class 1 individuals via a published\nmodel [4] and to prioritise patients likely to benefit most from\ntreatment [5].\n\nThe ADPKD Outcomes Model (OM) [6] utilises multivariate\nregression equations incorporating age, gender and TKV\nderived from the placebo arm of the TEMPO 3:4 trial [7] to\npredict underlying ADPKD progression; the model can also\nbe used to evaluate the impact of therapeutic intervention on\nprogression to ESRD and to simulate long-term outcomes\nsuch as ESRD management and life-expectancy [8].\n\nThis study aimed to contrast predictions of ADPKD\nprogression made based on the Mayo classification and\nusing the ADPKD OM, in terms of renal function decline\n(measured by estimated glomerular filtration rate (eGFR)).\n\nThe study also illustrates how predicted renal function\ntrajectories may be utilised to estimate ESRD incidence and\nconsequent requirements for care within the ADPKD OM." + }, + { + "id": 190117, + "strid": "811ce9a1-0009-42a6-9712-5dc392751538", + "image_id": 207919, + "image_name": "9118.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 114.502, + 2926.872, + 277.933, + 52.83199999999988 + ], + "priority": 5, + "parents": [ + 190145 + ], + "children": [ + 190127, + 190122, + 190138, + 190141, + 190126, + 190142, + 190131 + ], + "area": 335132.69774399995, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 190131, + "strid": "deaefbcc-e874-408c-8450-fbc9593f6199", + "image_id": 207919, + "image_name": "9118.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 118.731, + 3038.611, + 1053.08, + 866.6689999999999 + ], + "priority": 6, + "parents": [ + 190117 + ], + "children": [], + "area": 360777.322641, + "iscrowd": 0, + "segmentation": [], + "text": "Being a population enriched for likelihood of rapid\nprogression, approximately 90% of patients in the TEMPO\n3:4 trial were classified as 1C, 1D or 1E at baseline.\n\nTime-dependent renal decline trajectories and time to ESRD\n(eGFR<15 ml/min/m?) were predicted utilising the ADPKD\nOM and Mayo classification for each TEMPO 3:4 subgroup\n(1C-1E).\n\nTable 1 presents the mean baseline characteristics observed\nfor each subgroup; despite having similar levels of renal\nfunction at baseline, there was a trend of higher TKV ata\nyounger age in the mean profiles of 1E versus 1D and 1D\nversus 1C [9]. Gender distribution was assumed to be equal.\n\nRegression coefficients of the ADPKD OM’s natural history\nprogression equations and the Mayo classification model\nwere sampled to account for parameter uncertainty in rates\nof progression and to present a range of simulated renal\nfunction trajectories for each patient profile." + }, + { + "id": 190138, + "strid": "61c26d88-290f-462f-90dd-13fabf871fc6", + "image_id": 207919, + "image_name": "9118.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 111.545, + 4053.508, + 1070.039, + 321.6859999999997 + ], + "priority": 7, + "parents": [ + 190117 + ], + "children": [ + 190129 + ], + "area": 452148.54985999997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190129, + "strid": "467a9628-3a37-4a3b-b198-35f40dbdd9de", + "image_id": 207919, + "image_name": "9118.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 125.886, + 3963.374, + 920.663, + 77.59299999999985 + ], + "priority": 8, + "parents": [ + 190138 + ], + "children": [], + "area": 498933.299364, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1. Mean baseline characteristics of TEMPO 3:4 patients\nclassified as 1C, 1D and 1E at baseline" + }, + { + "id": 190141, + "strid": "b7faf8b6-011f-4315-a533-fadea16eb44b", + "image_id": 207919, + "image_name": "9118.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 128.309, + 4388.428, + 750.998, + 63.00799999999981 + ], + "priority": 9, + "parents": [ + 190117 + ], + "children": [], + "area": 563074.808252, + "iscrowd": 0, + "segmentation": [], + "text": "eGFR: estimated glomerular filtration rate, TKV: total kidney volume\nN=1,273; remaining patients classified as 1B (96) or 2 (42)" + }, + { + "id": 190122, + "strid": "2058b3e9-876d-4fef-8741-6f9b43a52c63", + "image_id": 207919, + "image_name": "9118.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1251.941, + 1078.579, + 1066.2160000000001, + 318.9559999999999 + ], + "priority": 10, + "parents": [ + 190117 + ], + "children": [ + 190119 + ], + "area": 1350317.271839, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190119, + "strid": "13519310-b87a-498d-ba67-60d4bcbb7993", + "image_id": 207919, + "image_name": "9118.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1265.453, + 988.634, + 1036.882, + 79.71499999999992 + ], + "priority": 11, + "parents": [ + 190122 + ], + "children": [], + "area": 1251069.861202, + "iscrowd": 0, + "segmentation": [], + "text": "Table 2. TKV boundaries of Mayo class 1C, 1D and 1E for mean ages\nobserved in each TEMPO 3:4 subgroup" + }, + { + "id": 190142, + "strid": "dbad0314-4b63-4e3a-af74-7a574bfdf1be", + "image_id": 207919, + "image_name": "9118.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1267.009, + 1415.013, + 803.0969999999998, + 59.59699999999998 + ], + "priority": 12, + "parents": [ + 190117 + ], + "children": [], + "area": 1792834.206117, + "iscrowd": 0, + "segmentation": [], + "text": "TKV: total kidney volume\n* TKV range based on bounds of each Mayo class and height 1.66-1.8m" + }, + { + "id": 190126, + "strid": "70c8288f-28c4-4130-9bf6-96a265954ff1", + "image_id": 207919, + "image_name": "9118.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1265.309, + 1542.364, + 1039.7169999999999, + 603.6259999999997 + ], + "priority": 13, + "parents": [ + 190117 + ], + "children": [], + "area": 1951567.050476, + "iscrowd": 0, + "segmentation": [], + "text": "The impact of within-class variation of TKV was assessed in\nthe ADPKD OM using the age-dependent upper and lower\nbounds of the Mayo classification (Table 2), while all other\ncharacteristics were held constant. Heights of 1.66m (lower)\nand 1.8m (upper) were utilised based on the TEMPO 3:4\ndata to convert height-adjusted TKV boundaries of each\nMayo class to TKV values.\n\nFinally, long-term outcomes were predicted within the\nADPKD OM (parameterised to a UK setting [8]) for cohorts\nof patients with each TEMPO 3:4 subgroup profile.\n\nThe following outcomes were estimated over a lifetime\nhorizon:" + }, + { + "id": 190127, + "strid": "2dd323cf-fe0c-4ffa-9447-40975ae849f1", + "image_id": 207919, + "image_name": "9118.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1340.928, + 2189.427, + 890.9170000000001, + 217.92700000000013 + ], + "priority": 14, + "parents": [ + 190117 + ], + "children": [], + "area": 2935863.9682560004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190118, + "strid": "c8e95a83-9d7b-4753-ba35-254d825bb17f", + "image_id": 207919, + "image_name": "9118.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1267.261, + 2538.356, + 225.30600000000004, + 56.514000000000124 + ], + "priority": 15, + "parents": [ + 190145 + ], + "children": [ + 190140, + 190123, + 190137, + 190132, + 190124, + 190125, + 190133 + ], + "area": 3216759.5629160004, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 190132, + "strid": "437cc764-39e2-47bc-abf7-cf771bf07745", + "image_id": 207919, + "image_name": "9118.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1266.749, + 2662.401, + 1029.4779999999998, + 681.7669999999998 + ], + "priority": 16, + "parents": [ + 190118 + ], + "children": [], + "area": 3372593.8043489996, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1 presents trajectories of renal function decline\n(eGFR) for each patient profile predicted using each model.\n\nThere was a high degree of overlap between the 95%\nprediction regions of the Mayo classification and ADPKD\nOM, with agreement between the approaches highest for\nthe 1E profile and lowest for the 1D profile.\n\nOn average, predicted renal decline was more rapid in the\nADPKD OM compared to the Mayo classification.\n\nThe larger degree of uncertainty presented around\npredictions made based on the Mayo classification may be\ninfluenced by differences in the implemented methods of\nsampling due to data limitations (i.e. multivariate in ADPKD\nOM versus independent for Mayo classification)." + }, + { + "id": 190137, + "strid": "dce0ef7b-d8e4-4ed3-8ef9-e1b07cc9a085", + "image_id": 207919, + "image_name": "9118.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1266.906, + 3416.658, + 1072.52, + 901.185 + ], + "priority": 17, + "parents": [ + 190118 + ], + "children": [ + 190130 + ], + "area": 4328584.520148, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190130, + "strid": "a0f46cb9-f16d-4217-88ab-f64081c6a3ef", + "image_id": 207919, + "image_name": "9118.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1279.158, + 4364.467, + 1038.8830000000003, + 80.30699999999979 + ], + "priority": 18, + "parents": [ + 190137 + ], + "children": [], + "area": 5582842.8787859995, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. Renal decline for TEMPO 3:4 1C, 1D and 1E profiles predicted\nusing the Mayo Classification and ADPKD OM" + }, + { + "id": 190123, + "strid": "5ba2243f-97c3-40f3-802e-a0f6f33de7d4", + "image_id": 207919, + "image_name": "9118.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2389.805, + 1077.126, + 1069.487, + 402.13200000000006 + ], + "priority": 19, + "parents": [ + 190118 + ], + "children": [ + 190120 + ], + "area": 2574121.1004299996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190120, + "strid": "c69545e7-b119-44f2-a30c-1080b9830b6d", + "image_id": 207919, + "image_name": "9118.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2404.358, + 988.102, + 1039.8379999999997, + 79.505 + ], + "priority": 20, + "parents": [ + 190123 + ], + "children": [], + "area": 2375750.948516, + "iscrowd": 0, + "segmentation": [], + "text": "Table 3. Long-term clinical outcomes predicted for TEMPO 3:4 1C, 1D\nand 1E profiles within the ADPKD OM" + }, + { + "id": 190125, + "strid": "81fd51d1-d0c6-49ce-a21b-b05680ba2e73", + "image_id": 207919, + "image_name": "9118.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2395.669, + 1549.25, + 1047.5529999999999, + 891.913 + ], + "priority": 21, + "parents": [ + 190118 + ], + "children": [], + "area": 3711490.19825, + "iscrowd": 0, + "segmentation": [], + "text": "Under each model, the predicted number of years to the\nonset of ESRD fell from Mayo Class 1C to 1D and from 1D\nto 1E, as shown in Figures 1 and 2.\n\nPredicted age at ESRD onset followed the same trend: 56.1\nand 60.6 years for the mean 1C profile under ADPKD OM\nand Mayo classification, respectively, versus 46.3 and 46.8\nyears for the mean 1E profile.\n\nThe largest range of times to ESRD predicted in the ADPKD\nOM as a consequence of within-class variation in TKV was\npredicted for the class 1C profile (Figure 2).\n\nFor the 1C and 1D profiles, the ADPKD OM predicted\nranges of 13 to 20 years and 11 to 15 years, respectively,\ncompared to 19.5 years and 15.5 years using the Mayo\nclassification.\n\nFor class 1E, which has no upper TKV bound, the ADPKD\nOM predicted times to ESRD of up to 12 years, compared to\n11.5 years using the Mayo classification." + }, + { + "id": 190124, + "strid": "1b15d608-b641-452b-bc8b-498102df9df9", + "image_id": 207919, + "image_name": "9118.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2401.836, + 2508.462, + 1048.879, + 589.721 + ], + "priority": 22, + "parents": [ + 190118 + ], + "children": [ + 190121 + ], + "area": 6024914.336231999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190121, + "strid": "af1b53d6-6ecd-4dde-9f0e-61b380ac0dc6", + "image_id": 207919, + "image_name": "9118.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2403.432, + 3139.58, + 1033.774, + 119.85300000000007 + ], + "priority": 23, + "parents": [ + 190124 + ], + "children": [], + "area": 7545767.038559999, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2. Within-class variability in time to ESRD for TEMPO 3:4 mean\nsubgroup profiles, predicted using the Mayo Classification and ADPKD\nOM (for TKV range)" + }, + { + "id": 190140, + "strid": "195876e8-b18a-45fc-94bb-87bd3561b269", + "image_id": 207919, + "image_name": "9118.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2403.175, + 3290.512, + 637.7660000000001, + 37.483999999999924 + ], + "priority": 24, + "parents": [ + 190118 + ], + "children": [], + "area": 7907676.175600001, + "iscrowd": 0, + "segmentation": [], + "text": "Upper bound for 1E presented at TKV 5,000 ml" + }, + { + "id": 190133, + "strid": "e04a9a6e-765c-4a87-92c6-99141d5a96eb", + "image_id": 207919, + "image_name": "9118.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2395.12, + 3403.995, + 1038.6909999999998, + 279.74299999999994 + ], + "priority": 25, + "parents": [ + 190118 + ], + "children": [], + "area": 8152976.504399999, + "iscrowd": 0, + "segmentation": [], + "text": "When initiated with the mean TEMPO 3:4 subgroup profiles,\nthe vast majority of simulated patients were predicted to\nreach ESRD within their lifetime; the expected duration of\ndialysis and the predicted number of transplants conducted\nincreased with decreased time to ESRD (profiles 1C to 1E)\n(Table 3)." + }, + { + "id": 190136, + "strid": "62ccb0b3-f78f-4910-bda8-99c99797a258", + "image_id": 207919, + "image_name": "9118.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2391.55, + 3804.281, + 402.8159999999998, + 52.16100000000006 + ], + "priority": 26, + "parents": [ + 190145 + ], + "children": [ + 190134 + ], + "area": 9098128.225550001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 190134, + "strid": "535bde99-1160-449c-b2e6-2f2bdc5b3f52", + "image_id": 207919, + "image_name": "9118.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2396.242, + 3918.367, + 1047.0749999999998, + 550.9170000000004 + ], + "priority": 27, + "parents": [ + 190136 + ], + "children": [], + "area": 9389355.576814001, + "iscrowd": 0, + "segmentation": [], + "text": "Predictions of renal decline obtained using the Mayo\nclassification and ADPKD OM were consistent. Differences\nin the results of the two approaches may reflect\nheterogeneity of study population and modelling methods.\n\nThe ADPKD OM complements the methodology of the Mayo\nclassification, enabling the identification of patients at\nhighest risk for rapid renal decline.\n\nThe ability to model long-term ESRD burden and the impact\nof therapeutic intervention may deliver additional insight to\naid planning of healthcare service delivery and the optimal\ntiming of treatment initiation, thus maximising patient benefit." + }, + { + "id": 190135, + "strid": "e9bf9566-f4dd-45d3-bbc5-f8006b263ea5", + "image_id": 207919, + "image_name": "9118.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 112.699, + 4569.659, + 344.843, + 57.38299999999981 + ], + "priority": 28, + "parents": [ + 190145 + ], + "children": [ + 190139, + 190143, + 190144 + ], + "area": 514995.99964099994, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 190139, + "strid": "6789d0f4-9a82-408b-b98c-4789dd3d2ea9", + "image_id": 207919, + "image_name": "9118.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 120.817, + 4669.529, + 971.248, + 182.21799999999985 + ], + "priority": 29, + "parents": [ + 190135 + ], + "children": [], + "area": 564158.4851930001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190143, + "strid": "7e8e1e9f-1e80-424b-8202-5f1fc9cf8611", + "image_id": 207919, + "image_name": "9118.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1322.775, + 4663.579, + 1008.844, + 204.44999999999982 + ], + "priority": 30, + "parents": [ + 190135 + ], + "children": [], + "area": 6168865.711725, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190144, + "strid": "6b1818d2-c492-4470-a996-37f10dd462b0", + "image_id": 207919, + "image_name": "9118.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2403.679, + 4670.147, + 1007.9949999999999, + 248.98199999999997 + ], + "priority": 31, + 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microstructural changes associated with Amyotrophic\nLateral Sclerosis." + }, + { + "id": 176466, + "strid": "cc80bc20-645c-46d0-b5f0-69abe40fda1a", + "image_id": 207388, + "image_name": "8001.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 629.431, + 506.54, + 2056.72, + 127.95400000000001 + ], + "priority": 2, + "parents": [ + 176483 + ], + "children": [], + "area": 318831.97874000005, + "iscrowd": 0, + "segmentation": [], + "text": "Broad R, Gabel M, Dowell N, Zhang H, Alexander D, Cercignani M, Leigh PN\n\nClinical Imaging Sciences Centre, Brighton and Sussex Medical School, University of Sussex, BN1 9RR" + }, + { + "id": 176467, + "strid": "fe0fe7c5-87c5-47b7-8bfc-87937920d841", + "image_id": 207388, + "image_name": "8001.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 371.48, + 752.126, + 442.659, + 94.56500000000005 + ], + "priority": 3, + "parents": [ + 176483 + ], + "children": [ + 176474 + ], + "area": 279399.76648, + "iscrowd": 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"id": 176468, + "strid": "bb830d33-99e3-4a92-98de-a5d3a1f29595", + "image_id": 207388, + "image_name": "8001.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1902.759, + 755.418, + 276.90700000000015, + 76.70100000000002 + ], + "priority": 9, + "parents": [ + 176483 + ], + "children": [ + 176475, + 176479 + ], + "area": 1437378.398262, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 176475, + "strid": "9b9f45b5-7c48-4963-826b-fe99ada1e682", + "image_id": 207388, + "image_name": "8001.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1143.561, + 929.631, + 2050.327, + 1290.1530000000002 + ], + "priority": 10, + "parents": [ + 176468 + ], + "children": [ + 176476 + ], + "area": 1063089.755991, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 176476, + "strid": "4a9cf750-fb12-45d6-a0da-82308b0811d8", + "image_id": 207388, + "image_name": "8001.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 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NODDI and DTI indices for whole brain comparison analysis between control and ALS groups.\nA: Neurite Density Index (NDI). B: Orientation Dispersion Index (ODI). C: Isometric Compartment (ISO).\nD: Fractional Anisotropy (FA). Results were accepted as significant for p<0.05 after FWE correction at\ncluster level, clusters formed with p<0.001. The diffusion data was analysed using NODDI toolbox.\"" + }, + { + "id": 176479, + "strid": "d011c3d7-9810-4f9a-9f73-c73c95d0708b", + "image_id": 207388, + "image_name": "8001.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1123.275, + 2478.867, + 2078.7, + 631.2780000000002 + ], + "priority": 12, + "parents": [ + 176468 + ], + "children": [], + "area": 2784449.3294250006, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 176471, + "strid": "254e9468-41a7-4de1-bd8f-88597cbf1adc", + "image_id": 207388, + "image_name": "8001.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1453.73, + 3203.295, + 404.183, + 78.32999999999993 + ], + "priority": 13, + "parents": [ + 176483 + ], + "children": [ + 176481 + ], + "area": 4656726.04035, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion" + }, + { + "id": 176481, + "strid": "2f5dbd4f-9c7a-4906-932b-eb1329902570", + "image_id": 207388, + "image_name": "8001.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1142.379, + 3378.324, + 1001.924, + 1215.324 + ], + "priority": 14, + "parents": [ + 176471 + ], + "children": [], + "area": 3859326.3927959995, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 176472, + "strid": "d6fbb669-4545-47ad-bf7d-cfd38ade975d", + "image_id": 207388, + "image_name": "8001.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2502.516, + 3205.575, + 413.442, + 73.58599999999979 + ], + "priority": 15, + "parents": [ + 176483 + ], + "children": [ + 176480 + ], + "area": 8022002.7266999995, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion" + }, + { + "id": 176480, + "strid": "ab718b05-f698-4835-ba54-148b75753fbe", + "image_id": 207388, + "image_name": "8001.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2212.089, + 3374.529, + 952.9409999999998, + 451.2199999999998 + ], + "priority": 16, + "parents": [ + 176472 + ], + "children": [], + "area": 7464758.481081, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 176473, + "strid": "17c2d394-fd48-411b-8755-97a6f605211f", + "image_id": 207388, + "image_name": "8001.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2505.782, + 3952.617, + 414.16899999999987, + 79.72499999999991 + ], + "priority": 17, + "parents": [ + 176483 + ], + "children": [ + 176482 + ], + "area": 9904396.531494, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 176482, + "strid": "53f3d376-c958-489a-8d10-931a8e50c1e9", + "image_id": 207388, + "image_name": "8001.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2214.566, + 4125.34, + 971.0079999999998, + 309.08299999999963 + ], + "priority": 18, + "parents": [ + 176473 + ], + "children": [], + "area": 9135837.70244, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 2799, + "strid": "918ff108-0b53-4007-81d6-1683f0dddefd", + "image_id": 200614, + "image_name": "10382.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 43.49, + 15.43, + 145.47, + 145.47 + ], + "priority": -1, + "parents": [], + "children": [ + 2783, + 2788, + 2784, + 2789, + 2782, + 2785, + 2786, + 2787 + ], + "area": 671.0507, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 2788, + "strid": "88ac3ae2-cffe-4c92-9721-03c459e3bba8", + "image_id": 200614, + "image_name": "10382.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 254.084, + 195.318, + 1432.444, + 290.004 + ], + "priority": 1, + "parents": [ + 2799 + ], + "children": [], + "area": 49627.178712, + "iscrowd": 0, + "segmentation": [], + "text": "Retrospective analysis of trends in outcome following\nOut of Hospital Cardiac Arrest\nfrom a UK regional cardiac arrest centre,\nwith a focus on haematological parameters" + }, + { + "id": 2789, + "strid": "5237fef1-c279-4c3d-99ee-6f55dbbec5cb", + "image_id": 200614, + "image_name": "10382.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 409.865, + 523.192, + 1119.861, + 45.11800000000005 + ], + "priority": 2, + "parents": [ + 2799 + ], + "children": [], + "area": 214438.08908, + "iscrowd": 0, + "segmentation": [], + "text": "A. Skorko, M. Thomas. Bristol Royal Infirmary, Bristol, United Kingdom" + }, + { + "id": 2782, + "strid": "8359ed8f-06b3-4303-802f-471fbb57d631", + "image_id": 200614, + "image_name": "10382.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 844.608, + 637.805, + 252.9079999999999, + 42.089000000000055 + ], + "priority": 3, + "parents": [ + 2799 + ], + "children": [ + 2790 + ], + "area": 538695.2054399999, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 2790, + "strid": "6c47c714-4cbe-4955-bd89-9d76d4f46b42", + "image_id": 200614, + "image_name": "10382.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 113.902, + 702.938, + 1722.916, + 418.4440000000001 + ], + "priority": 4, + "parents": [ + 2782 + ], + "children": [], + "area": 80066.044076, + "iscrowd": 0, + "segmentation": [], + "text": "The Bristol Royal Infirmary is a tertiary centre for the management of out of hospital cardiac arrests (OHCA), covering a metropolitan population of\n1,000,000 in the South West of England. Since 2008 there has been a steady rise in the number of patients treated at our centre.\n\nAn ongoing matter for debate in the treatment of patients following OHCA is what the optimal antiplatelet drug strategy that should be delivered,\ngiven the concerns of both bleeding and clotting complications.\n\nThere is often reticence on the part of the intensive care teams to give full antiplatelet therapy to OHCA survivors, due to the perceived risk of\nbleeding. Studies vary in the rates of bleeding seen in this population, from 0 to 56% (1). However rates of acute in-stent thrombosis in this population\nare as high as 10%, compared to 2% in the acute ST elevation (STEMI) population(2).\n\nTherefore the need to balance the bleeding and thrombosis risks is of upmost importance.\n\nWe present the overall survival of patients treated following out of hospital cardiac arrest, alongside haematological parameters in the first 24 hours,\nin one UK centre over the period January 2009 to August 2016." + }, + { + "id": 2783, + "strid": "79c32a5a-be41-4738-ab19-46600b829515", + "image_id": 200614, + "image_name": "10382.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 888.667, + 1154.52, + 161.81100000000004, + 41.44800000000009 + ], + "priority": 5, + "parents": [ + 2799 + ], + "children": [ + 2791 + ], + "area": 1025983.82484, + "iscrowd": 0, + "segmentation": [], + "text": "Method" + }, + { + "id": 2791, + "strid": "a4af9008-c3d7-4758-8d56-5df967c838df", + "image_id": 200614, + "image_name": "10382.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 115.156, + 1219.807, + 1712.494, + 293.42599999999993 + ], + "priority": 6, + "parents": [ + 2783 + ], + "children": [], + "area": 140468.09489200002, + "iscrowd": 0, + "segmentation": [], + "text": "To understand why OHCA survivors may be at risk of bleeding and to try to quantify whether this impacts survival to hospital discharge, we\nretrospectively analysed laboratory parameters of coagulation (PT and APTT) and platelet count, alongside the haemoglobin value and stratified these\nby survival to hospital discharge.\n\nRoutinely collected data was used to identify patients for this analysis. Data was extracted for those coded as ‘Anoxic or ischaemic coma or\nencephalopathy’ with ‘Acute myocardial infarction’ or ‘Ventricular tachycardia or fibrillation’. Our electronic records began in December 2008 and\ncontinue to the present day. Data for 2016 is available up to and including August. Parameters of ‘status at hospital discharge’, lowest platelet count,\nAPTT and lowest haemoglobin within 24 hours of admission were extracted from the database." + }, + { + "id": 2784, + "strid": "d6cd2a15-a6ad-4b1a-a624-44708a7069dc", + "image_id": 200614, + "image_name": "10382.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 895.181, + 1547.228, + 147.096, + 45.48700000000008 + ], + "priority": 7, + "parents": [ + 2799 + ], + "children": [], + "area": 1385049.1082680002, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 2785, + "strid": "9bde04e9-4b3a-4ee1-b058-0a9ca877a330", + "image_id": 200614, + "image_name": "10382.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 684.81, + 1625.581, + 569.52, + 38.274000000000115 + ], + "priority": 8, + "parents": [ + 2799 + ], + "children": [ + 2794, + 2795 + ], + "area": 1113214.1246099998, + "iscrowd": 0, + "segmentation": [], + "text": "Rates of admission and survival" + }, + { + "id": 2794, + "strid": "1ff46b20-aec1-4756-88ba-2ae6451da061", + "image_id": 200614, + "image_name": "10382.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 122.563, + 1785.421, + 927.83, + 627.3170000000002 + ], + "priority": 9, + "parents": [ + 2785 + ], + "children": [ + 2796 + ], + "area": 218826.554023, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 2796, + "strid": "d4db7943-bc0c-4c85-8691-b1e15f6d347c", + "image_id": 200614, + "image_name": "10382.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 249.53, + 1723.906, + 661.183, + 58.21900000000005 + ], + "priority": 10, + "parents": [ + 2794 + ], + "children": [], + "area": 430166.26418, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1: Number of OHCA patients admitted to the BRI and\nmortality rate by year (2009-2016)" + }, + { + "id": 2795, + "strid": "d23ede7e-f44c-48b1-9199-188191bfeef1", + "image_id": 200614, + "image_name": "10382.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1083.105, + 1936.725, + 734.8820000000001, + 484.1419999999998 + ], + "priority": 11, + "parents": [ + 2785 + ], + "children": [ + 2797 + ], + "area": 2097676.5311249997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 2797, + "strid": "5b003b36-aee2-495f-85c3-53be9078234f", + "image_id": 200614, + "image_name": "10382.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1091.807, + 1728.072, + 729.194, + 178.519 + ], + "priority": 12, + "parents": [ + 2795 + ], + "children": [], + "area": 1886721.106104, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1 demonstrates an upward trend in the number of\npatients been treated by our unit, at the same time as hospital\nmortality has shown a downward trend. The outcomes for\nsurvival in our unit are consistently below the national\n\naverage(3)." + }, + { + "id": 2786, + "strid": "1e75dc3f-6d2c-4189-a52e-aa77857c3890", + "image_id": 200614, + "image_name": "10382.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 561.397, + 2468.079, + 817.522, + 43.21199999999999 + ], + "priority": 13, + "parents": [ + 2799 + ], + "children": [ + 2792, + 2798 + ], + "area": 1385572.1463630002, + "iscrowd": 0, + "segmentation": [], + "text": "Parameters of coagulation and platelet count" + }, + { + "id": 2792, + "strid": "2c512526-2a81-4448-9c3c-bfa54936d1ec", + "image_id": 200614, + "image_name": "10382.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 116.411, + 2544.049, + 1684.953, + 69.30200000000013 + ], + "priority": 14, + "parents": [ + 2786 + ], + "children": [], + "area": 296155.288139, + "iscrowd": 0, + "segmentation": [], + "text": "Analysing the differences between survivors and non survivors as regards the coagulation parameters in the first 24 hours, demonstrates that there is\nno clinically significant difference in haemoglobin level, platelet counts, PT, or APTT parameters (see table above)." + }, + { + "id": 2798, + "strid": "fce579ff-db87-4be4-91fa-6db8a81a590b", + "image_id": 200614, + "image_name": "10382.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 116.202, + 2633.298, + 1008.576, + 130.5619999999999 + ], + "priority": 15, + "parents": [ + 2786 + ], + "children": [], + "area": 305994.494196, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 2787, + "strid": "fb9ec2d5-e1f1-4b2a-8f25-bbef110d13d0", + "image_id": 200614, + "image_name": "10382.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 855.014, + 2800.468, + 225.1250000000001, + 40.391999999999825 + ], + "priority": 16, + "parents": [ + 2799 + ], + "children": [ + 2793 + ], + "area": 2394439.346552, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion" + }, + { + "id": 2793, + "strid": "35cd035d-9afe-4683-8ff8-c1cabce04dc9", + "image_id": 200614, + "image_name": "10382.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 113.991, + 2866.477, + 1707.336, + 308.8249999999998 + ], + "priority": 17, + "parents": [ + 2787 + ], + "children": [], + "area": 326752.579707, + "iscrowd": 0, + "segmentation": [], + "text": "Our data demonstrates that absolute platelet count, haemoglobin, PT and APTT in the first 24 hours do not differ between survivors and non-survivors\nof OHCA. Abnormalities in platelet count or coagulation markers within the first 24 hours of admission do not explain differences between survivors\nand non survivors of OHCA.\n\nHowever, absolute values do not give an indication as to the function of platelets or of the coagulation cascade. An analysis of platelet function and\nthe coagulation cascade as a whole may provide better insights into the risks of bleeding in this population.\n\nWe therefore propose to carry out a prospective analysis of thromoelastometric coagulation assessment and platelet inhibition, and correlate this with\nbleeding events and administration of antiplatelet therapy." + }, + { + "id": 111378, + "strid": "03785966-2900-4fcb-bfdf-30bc195ec322", + "image_id": 204823, + "image_name": "13199.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 758.72, + 702.05, + 442.4100000000001, + 194.04000000000008 + ], + "priority": -1, + "parents": [], + "children": [ + 111362, + 111361, + 111368, + 111366, + 111367, + 111364 + ], + "area": 532659.3759999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 111361, + "strid": "bea4fdef-8847-4cd7-8962-6e1fa2aa455d", + "image_id": 204823, + "image_name": "13199.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 1002.008, + 338.615, + 3538.808, + 296.98199999999997 + ], + "priority": 1, + "parents": [ + 111378 + ], + "children": [], + "area": 339294.93892000004, + "iscrowd": 0, + "segmentation": [], + "text": "OPTIC NERVE LYMPHOMA:\nADDRESSING LIMITATIONS OF AN ACTIVE INTERVENTION" + }, + { + "id": 111362, + "strid": "00b8a350-8e00-4380-b076-360fbf0422a9", + "image_id": 204823, + "image_name": "13199.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1484.951, + 674.455, + 2584.023, + 227.59399999999994 + ], + "priority": 2, + "parents": [ + 111378 + ], + "children": [], + "area": 1001532.6267050001, + "iscrowd": 0, + "segmentation": [], + "text": "Rohan Bir Singh, Parul Ichhpujani, Sahil Thakur\nDepartment of Ophthalmology, Government Medical College & Hospital, Sector 32-A, Chandigarh, India.\nEmail : dr.rohandhaliwal@gmail.com; itsdrparul@gmail.com" + }, + { + "id": 111368, + "strid": "75c25ae0-28c0-47f3-bdb9-eb6b9e99f232", + "image_id": 204823, + "image_name": "13199.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 220.466, + 1017.112, + 309.64099999999996, + 70.52900000000011 + ], + "priority": 3, + "parents": [ + 111378 + ], + "children": [ + 111363 + ], + "area": 224238.614192, + "iscrowd": 0, + "segmentation": [], + "text": "Purpose :" + }, + { + "id": 111363, + "strid": "00056b9f-32ec-45b6-9419-5e5886d23f54", + "image_id": 204823, + "image_name": "13199.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 216.141, + 1103.743, + 1543.588, + 443.451 + ], + "priority": 4, + "parents": [ + 111368 + ], + "children": [], + "area": 238564.11576299998, + "iscrowd": 0, + "segmentation": [], + "text": "Studying limitations of active intervention in a rare\ncase of refractory optic nerve lymphoma ina\nCHOP(cyclophosphamide, doxorubicin, vincristine,\nand prednisone) treated NHL (Non Hodgkin\nLymphoma) & B-cell Type IV(Ann Arbor Staging)" + }, + { + "id": 111364, + "strid": "0ed44e3e-0ab7-4ae1-8ea6-6849275bfd14", + "image_id": 204823, + "image_name": "13199.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 213.756, + 1591.603, + 308.08400000000006, + 69.38799999999992 + ], + "priority": 5, + "parents": [ + 111378 + ], + "children": [ + 111375, + 111370, + 111372, + 111369, + 111371, + 111374 + ], + "area": 340214.69086800003, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 111369, + "strid": "828bafe8-2711-44a0-bd32-e760ffa5884e", + "image_id": 204823, + "image_name": "13199.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 213.585, + 1684.559, + 1617.012, + 705.2920000000001 + ], + "priority": 6, + "parents": [ + 111364 + ], + "children": [], + "area": 359796.534015, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 111370, + "strid": "8806ebe5-36c9-4882-ba2e-4e1a60e7a49a", + "image_id": 204823, + "image_name": "13199.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 219.32, + 2407.054, + 1585.474, + 346.9119999999998 + ], + "priority": 7, + "parents": [ + 111364 + ], + "children": [], + "area": 527915.08328, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 111371, + "strid": "d0dc425c-d6df-4cae-909e-35708a082ea0", + "image_id": 204823, + "image_name": "13199.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 213.585, + 2765.434, + 1622.746, + 702.4250000000002 + ], + "priority": 8, + "parents": [ + 111364 + ], + "children": [], + "area": 590655.2208900001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 111372, + "strid": "f607cf6b-1ea6-4696-b0dc-1bffe80daa5f", + "image_id": 204823, + "image_name": "13199.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 216.453, + 3490.796, + 1668.619, + 794.1709999999998 + ], + "priority": 9, + "parents": [ + 111364 + ], + "children": [], + "area": 755593.266588, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 111374, + "strid": "d9a30f86-ffd1-4a71-a009-8335f20b31c2", + "image_id": 204823, + "image_name": "13199.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2003.712, + 999.473, + 1600.7649999999999, + 1761.183 + ], + "priority": 10, + "parents": [ + 111364 + ], + "children": [ + 111376 + ], + "area": 2002656.043776, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 111376, + "strid": "9fb57c01-a1e6-4677-be5a-982003895736", + "image_id": 204823, + "image_name": "13199.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2023.216, + 2811.853, + 1562.7329999999997, + 195.0369999999998 + ], + "priority": 11, + "parents": [ + 111374 + ], + "children": [], + "area": 5688985.979247999, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1: A: OU: Normal Adnexa, B: Unremarkable posterior segment;\nC:HVF 30-2 revealed peripheral field loss in OD with enlargement of\nblind spot with progressive constriction in follow up field." + }, + { + "id": 111375, + "strid": "b7cbef57-0396-44d0-8f66-0a2e46691d7d", + "image_id": 204823, + "image_name": "13199.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3932.139, + 992.646, + 1198.0140000000001, + 1774.836 + ], + "priority": 12, + "parents": [ + 111364 + ], + "children": [ + 111377 + ], + "area": 3903222.049794, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 111377, + "strid": "c24bfcc0-bfe5-4278-99cd-6156d1e44715", + "image_id": 204823, + "image_name": "13199.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 3629.832, + 2814.291, + 1774.8359999999998, + 260.8620000000001 + ], + "priority": 13, + "parents": [ + 111375 + ], + "children": [], + "area": 10215403.529112, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2: A: MRI showing focal areas of thickening and signal change in the\nintracanalicular segment of left optic nerve approximately 11mm x 6.5mm,B:\nT2 sequence showing multiple sclerosed skull metastases ,C:Follow up imaging\nshowed bilateral optic nerve involvement with several newer metastases" + }, + { + "id": 111367, + "strid": "0e040537-3975-4f26-a68e-cb9f356e4391", + "image_id": 204823, + "image_name": "13199.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1939.252, + 3167.069, + 259.616, + 66.08399999999983 + ], + "priority": 14, + "parents": [ + 111378 + ], + "children": [ + 111365 + ], + "area": 6141744.892388, + "iscrowd": 0, + "segmentation": [], + "text": "Results:" + }, + { + "id": 111365, + "strid": "ce5cc94f-9f81-4767-9897-4d379833e073", + "image_id": 204823, + "image_name": "13199.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1934.531, + 3254.394, + 3424.577, + 346.942 + ], + "priority": 15, + "parents": [ + 111367 + ], + "children": [], + "area": 6295726.079213999, + "iscrowd": 0, + "segmentation": [], + "text": "The patient underwent repeat imaging, which showed bilateral optic nerve involvement with several newer\nmetastasis in skull. BCVA reduced to 20/120 in OD and PL negative in OS. The visual field constriction was noted on\nsubsequent visits in right eye with compromised auditory function.The patient’s general physical condition also\ndeteriorated rapidly & she became non-ambulatory after a month of optic nerve involvement." + }, + { + "id": 111366, + "strid": "95b45081-2b17-4ae6-9618-286ada956f4e", + "image_id": 204823, + "image_name": "13199.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1939.252, + 3617.857, + 417.7460000000001, + 66.08399999999983 + ], + "priority": 16, + "parents": [ + 111378 + ], + "children": [ + 111373 + ], + "area": 7015936.422964, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions:" + }, + { + "id": 111373, + "strid": "96a22a3d-6ac1-44d9-a2d8-cf0305c04d8b", + "image_id": 204823, + "image_name": "13199.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1936.678, + 3714.425, + 3477.7220000000007, + 513.201 + ], + "priority": 17, + "parents": [ + 111366 + ], + "children": [], + "area": 7193645.18015, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 164033, + "strid": "d7d7d21f-e717-4f47-8036-0b8d8e6dd180", + "image_id": 206899, + "image_name": "6608.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 97.35, + 86.33, + -97.35, + -86.33 + ], + "priority": -1, + "parents": [], + "children": [ + 164009, + 164010, + 164013, + 164011, + 164012, + 164014 + ], + "area": 8404.225499999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 164009, + "strid": "26e13149-086b-4c9a-9305-fff4a57f6efa", + "image_id": 206899, + "image_name": "6608.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 741.222, + 132.314, + 1442.015, + 164.02899999999997 + ], + "priority": 1, + "parents": [ + 164033 + ], + "children": [], + "area": 98074.047708, + "iscrowd": 0, + "segmentation": [], + "text": "Models Of Residue Conservation Reveal\nFunctional Breaks In Chinese Hamster Ovary Cell" + }, + { + "id": 164010, + "strid": "cdff9a46-f931-4dc0-9c3d-6d8302737faa", + "image_id": 206899, + "image_name": "6608.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1166.543, + 298.991, + 619.846, + 44.14300000000003 + ], + "priority": 2, + "parents": [ + 164033 + ], + "children": [], + "area": 348785.85811299994, + "iscrowd": 0, + "segmentation": [], + "text": "Qixun Fang, Paul Dobson, David James" + }, + { + "id": 164011, + "strid": "5b8a4fc3-8cc0-49cb-96b8-cde6c0f68e59", + "image_id": 206899, + "image_name": "6608.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 405.256, + 448.897, + 305.29100000000005, + 49.065 + ], + "priority": 3, + "parents": [ + 164033 + ], + "children": [ + 164015 + ], + "area": 181918.20263199997, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 164015, + "strid": "4b15c11d-ca5c-4a9f-bf23-843cca2f3284", + "image_id": 206899, + "image_name": "6608.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 77.791, + 519.416, + 967.6320000000001, + 961.2129999999999 + ], + "priority": 4, + "parents": [ + 164011 + ], + "children": [], + "area": 40405.890056000004, + "iscrowd": 0, + "segmentation": [], + "text": "Although the Chinese Hamster Ovary cell (CHO) is rather important in\nbiopharmaceutical manufacturing, knowledge of its cell biology\nremains limited. A better understanding may be developed from CHO\ngenome analysis but the genome annotation level is still low. In this\nproject, we are interested in sophisticated protein sequence annotation\nusing residue conservation. Residues that are conserved across species\nare considered functional critical for the proteins. We identified these\nresidues in homologues and integrate them into models which then are\nused to compare with CHO proteins. CHO proteins with certain\nconservation pattern matched with the model are considered as one of\nthe corresponding homologue group and, therefore, functional as other\nproteins in the group. However, as a cancer cell line, CHO adopted\nmany mutations that significantly break the protein function which is\nmore interesting to us. The results are further mapped onto Gene\nOntology (GO) to gain a higher level function annotation with term\nenrichment. While the genome only decides the capability of the cell,\nthe transcriptome could provide the real-time function profile of the\ncell when the models are applied. Besides, the transcriptome should\nalso confirm the model predictions in cell function level and, in term,\nimprove the models by suggesting inaccurate predictions. After that,\nthe in-sequence details are investigated with sites annotations from\nUniprot, which will provide specific information that how the protein is\nbroken. Breaks in genome level and cell function level is concluded\nhere." + }, + { + "id": 164013, + "strid": "eaba950e-5fe0-454f-bf1e-640543b83b8b", + "image_id": 206899, + "image_name": "6608.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 402.46, + 1626.397, + 320.33099999999996, + 59.753999999999905 + ], + "priority": 5, + "parents": [ + 164033 + ], + "children": [ + 164021, + 164032 + ], + "area": 654559.73662, + "iscrowd": 0, + "segmentation": [], + "text": "Methodology" + }, + { + "id": 164032, + "strid": "9852eada-96c7-4a53-b00f-5cd1cd26fd2f", + "image_id": 206899, + "image_name": "6608.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 78.101, + 1719.505, + 968.2689999999999, + 2133.921 + ], + "priority": 6, + "parents": [ + 164013 + ], + "children": [], + "area": 134295.060005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 164021, + "strid": "fbe129cf-f749-4013-884b-0d524cf251e9", + "image_id": 206899, + "image_name": "6608.png", + 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}, + { + "id": 32629, + "strid": "cefdcd49-d093-4e36-bc0b-68852d312815", + "image_id": 201778, + "image_name": "11767.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 98.142, + 366.815, + 3370.741, + 228.02900000000005 + ], + "priority": 2, + "parents": [ + 32643 + ], + "children": [], + "area": 35999.95773, + "iscrowd": 0, + "segmentation": [], + "text": "Tiago Chedraoui Silva!*, Antonio Colaprico?-+, Catharina Olsen?+, Gianluca Bontempi?+, Michele Ceccarelli>-©, Benjamin Berman”, Houtan Noushmehr!.7*\n\n! Department of Genetics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil 2 Center for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, Los Angeles, CA, USA\n3 Interuniversity Institute of Bioinformatics in Brussels (IB), Brussels, Belgium + Machine Learning Group, ULB, Brussels, Belgium * Bioinformatics Laboratory, BIOGEM, Ariano Irpino, Avellino, Italy\n6 Department of Science and Technology, University of Sannio, Benevento, Italy 7 Department of Neurosurgery, Henry Ford Hospital, Detroit, MI, USA" + }, + { + "id": 32630, + "strid": "d74c7297-5676-4173-a1af-523d7aeb58e5", + "image_id": 201778, + "image_name": "11767.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 97.528, + 682.377, + 562.53, + 56.46600000000001 + ], + "priority": 3, + "parents": [ + 32643 + ], + "children": [ + 32631 + ], + "area": 66550.864056, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 32631, + "strid": "742185f4-2fcb-4082-a9a8-50b1532f8206", + "image_id": 201778, + "image_name": "11767.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 91.243, + 764.247, + 1588.408, + 531.103 + ], + "priority": 4, + "parents": [ + 32630 + ], + "children": [], + "area": 69732.189021, + "iscrowd": 0, + "segmentation": [], + "text": "The Genomic Data Commons (GDC) provides a rich resource of molecular\nand clinical data of more than 14,000 tumor patients across 38 different\ncancer types and subtypes. Recently, we developed the R/Bioconductor\npackage TCGAbiolinks, which allows users to search, download and prepare\ncancer genomics data for integrative data analysis from the GDC database.\nHowever, its use requires advanced knowledge of R thus limiting the total\nnumber of users. To overcome this obstacle and improve the accessibility of\nthe package by a wider range of users, we developed a graphical user\ninterface (GUI)." + }, + { + "id": 32632, + "strid": "d90433c8-6e70-4707-a722-8740a1d0f3e0", + "image_id": 201778, + "image_name": "11767.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 93.278, + 1345.905, + 358.516, + 54.789999999999964 + ], + "priority": 5, + "parents": [ + 32643 + ], + "children": [ + 32633 + ], + "area": 125543.32659000001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 32633, + "strid": "a566f74a-ca81-4911-83e5-92bf51120c51", + "image_id": 201778, + "image_name": "11767.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 86.66, + 1441.787, + 1593.072, + 297.77099999999996 + ], + "priority": 6, + "parents": [ + 32632 + ], + "children": [], + "area": 124945.26142, + "iscrowd": 0, + "segmentation": [], + "text": "This tool was built on the statistical programming language R and uses the\nweb application framework shiny to provide a GUI. Through an available\nApplication Programming Interface it connects to the GDC database to search,\ndownload and prepare the data into a standard Bioconductor data structure\nwhich encompasses both molecular and clinical data in the same object." + }, + { + "id": 32634, + "strid": "a0f517b5-eb3a-40cb-80e2-e412711ca576", + "image_id": 201778, + "image_name": "11767.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 84.142, + 1792.008, + 429.449, + 63.583000000000084 + ], + "priority": 7, + "parents": [ + 32643 + ], + "children": [ + 32642, + 32636 + ], + "area": 150783.137136, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 32642, + "strid": "a3e8c6e9-029f-4221-afc7-9e6180574ac1", + "image_id": 201778, + "image_name": "11767.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 78.256, + 1888.232, + 1419.573, + 190.73599999999988 + ], + "priority": 8, + "parents": [ + 32634 + ], + "children": [], + "area": 147765.483392, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 32636, + "strid": "3b2fda2e-3b2c-4382-b7b4-e7ee6d0e599c", + "image_id": 201778, + "image_name": "11767.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1695.093, + 664.699, + 1807.291, + 1427.7599999999998 + ], + "priority": 9, + "parents": [ + 32634 + ], + "children": [ + 32635 + ], + "area": 1126726.622007, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 32635, + "strid": "7edbc72c-7057-47d2-9220-5dc50a226d1f", + "image_id": 201778, + "image_name": "11767.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1864.09, + 2107.129, + 1452.704, + 55.6909999999998 + ], + "priority": 10, + "parents": [ + 32636 + ], + "children": [], + "area": 3927878.0976099996, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1: Example of integrative analysis workflow in TCAbiolinksGUI" + }, + { + "id": 32637, + "strid": "faeea231-ac67-4c1a-ab18-28d2b945e23c", + "image_id": 201778, + "image_name": "11767.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 82.828, + 2140.454, + 275.919, + 60.47499999999991 + ], + "priority": 11, + "parents": [ + 32643 + ], + "children": [ + 32639 + ], + "area": 177289.52391200003, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 32639, + "strid": "2b221c4f-f573-4652-99f0-875bec18f456", + "image_id": 201778, + "image_name": "11767.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 64.027, + 2232.212, + 3429.886, + 1654.297 + ], + "priority": 12, + "parents": [ + 32637 + ], + "children": [ + 32638 + ], + "area": 142921.837724, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 32638, + "strid": "5e13f5c5-de3d-4642-b362-c3c2d240670e", + "image_id": 201778, + "image_name": "11767.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1291.801, + 3889.158, + 979.1889999999999, + 54.55099999999993 + ], + "priority": 13, + "parents": [ + 32639 + ], + "children": [], + "area": 5024018.193558, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2: TCAbiolinksGUI - Volcano plot menu" + }, + { + "id": 32640, + "strid": "b326ef58-1d5f-4274-a7e6-19ccbc4fb8bf", + "image_id": 201778, + "image_name": "11767.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 77.466, + 4005.91, + 470.774, + 55.54399999999987 + ], + "priority": 14, + "parents": [ + 32643 + ], + "children": [ + 32641 + ], + "area": 310321.82405999996, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 32641, + "strid": "466ab5ba-e064-4534-936b-b9d4a606fca5", + "image_id": 201778, + "image_name": "11767.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 71.925, + 4085.122, + 1594.735, + 362.3600000000001 + ], + "priority": 15, + "parents": [ + 32640 + ], + "children": [], + "area": 293822.39985, + "iscrowd": 0, + "segmentation": [], + "text": "The tool, which is the only one accessing molecular and clinical data from the\nGDC database, has been shown to be very useful to the scientific community\nand by making this open source tool available through the Bioconductor\nproject and by creating a GUI to facilitate its use, we hope it can help a large\nnumber of cancer researchers understand the molecular biology of malignant\ncells resulting in more accurate diagnoses and efficient therapies in the future." + }, + { + "id": 134054, + "strid": "0f6fc43a-f211-429e-b32c-1fe5b619846c", + "image_id": 205699, + "image_name": "15626.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 118.02, + 134.85, + 208.51, + 196.92 + ], + "priority": -1, + "parents": [], + "children": [ + 134041, + 134031, + 134023, + 134025, + 134040, + 134053, + 134037, + 134034, + 134024, + 134044, + 134043, + 134045, + 134047, + 134026, + 134033, + 134032, + 134042, + 134035, + 134028, + 134022, + 134027 + ], + "area": 15914.997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 134022, + "strid": "a6ae85df-1ccf-4adc-9125-b282f41d9644", + "image_id": 205699, + "image_name": "15626.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 576.382, + 100.778, + 3668.904, + 160.88299999999998 + ], + "priority": 1, + "parents": [ + 134054 + ], + "children": [], + "area": 58086.625196, + "iscrowd": 0, + "segmentation": [], + "text": "PUMA: Pipeline for Undergraduate Microbiome Analysis" + }, + { + "id": 134023, + "strid": "c1c89b2c-a313-42d3-b19f-2dc6303db43f", + "image_id": 205699, + "image_name": "15626.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 879.626, + 295.761, + 2853.8899999999994, + 273.40000000000003 + ], + "priority": 2, + "parents": [ + 134054 + ], + "children": [], + "area": 260159.065386, + "iscrowd": 0, + "segmentation": [], + "text": "Keith Mitchell, Christopher Dao, Jiem Ronas, Amanda Freise, and Jordan Moberg Parker\n\nmunology Department of Microbiology, Immunology, and Molecular Genetics\nnetics University of California, Los Angeles" + }, + { + "id": 134024, + "strid": "3cbab785-31cb-4c4a-8798-b4a42be76eba", + "image_id": 205699, + "image_name": "15626.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 680.981, + 644.897, + 243.13200000000006, + 62.197 + ], + "priority": 3, + "parents": [ + 134054 + ], + "children": [ + 134029 + ], + "area": 439162.603957, + "iscrowd": 0, + "segmentation": [], + "text": "Abstract" + }, + { + "id": 134029, + "strid": "b6ed5810-06fc-40ba-b94b-f0f8d85184fc", + "image_id": 205699, + "image_name": "15626.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 53.102, + 733.697, + 1500.627, + 1116.0259999999998 + ], + "priority": 4, + "parents": [ + 134024 + ], + "children": [], + "area": 38960.778094, + "iscrowd": 0, + "segmentation": [], + "text": "Microbiome research is an attractive direction for new course-based undergraduate research\nexperiences (CURES), as sample collection is relatively straightforward and the resulting large\ndatasets give students an opportunity to ask a variety of questions. Current research in\nmicrobiology requires scientists to synthesize a background of experimental design with\ncomputational and statistical analysis. Despite the need for collaborations between computer\nscience and biology, current academic programs at the undergraduate level often do not\nprovide sufficient practice in bioinformatics, biostatistics, and other intersections between the\ntwo fields. To address this situation we developed the Pipeline for Undergraduate Microbiome\nAnalysis (PUMA), which combines previously published processes and tools for microbiome\nresearch with a set of custom “plug and play” python scripts for processing 16S sequencing\ndata from a variety of sources. We also developed accompanying instructional modules and\nvideo tutorials to teach students both the theory behind the analysis tools and the skills for\nneeded for visualizing and interpreting biostatistical data. We hypothesized that students\nusing PUMA would be able to formulate and _ statistically test hypotheses linking\nenvironmental parameters (metadata) to diversity metrics, community composition, and\ninferred functional profiles. PUMA was assessed using entry/exit surveys and reflection\nquestions designed to gauge the students’ comfort with integrating computational analysis\nwith microbiology, and the Statistical Reasoning in Biology Concept Inventory (SRBCI).\nPreliminary qualitative analysis of surveys and reflection questions saw an increase in\nstudents’ self-reported confidence levels in using the analysis tools. Students assessed also\nimproved their competencies with biostatistics as demonstrated by the 10.5% improvement in\nthe average score on the SRBCI. PUMA takes 16S sequencing data and seamlessly transitions\nto a suite of programs for microbiome data visualization and analysis, all of which are easily\naccessible to undergraduates without command line experience." + }, + { + "id": 134025, + "strid": "94d6b4ce-9200-4b86-94ec-2851fa683684", + "image_id": 205699, + "image_name": "15626.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 668.867, + 1890.799, + 270.94100000000003, + 57.325000000000045 + ], + "priority": 5, + "parents": [ + 134054 + ], + "children": [ + 134038, + 134030 + ], + "area": 1264693.054733, + "iscrowd": 0, + "segmentation": [], + "text": "Overview" + }, + { + "id": 134038, + "strid": "fa25946f-6de0-41a7-8078-28cfa9931fa7", + "image_id": 205699, + "image_name": "15626.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 54.794, + 1972.566, + 1433.852, + 1603.0830000000003 + ], + "priority": 6, + "parents": [ + 134025 + ], + "children": [], + "area": 108084.781404, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 134030, + "strid": "94e69804-1595-492a-8e20-0fa04f9e2982", + "image_id": 205699, + "image_name": "15626.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 450.341, + 3438.213, + 1039.621, + 126.92200000000003 + ], + "priority": 7, + "parents": [ + 134025 + ], + "children": [], + "area": 1548368.2806330002, + "iscrowd": 0, + "segmentation": [], + "text": "Differential abundance analysis of community\nand inferred functional profiles in STAMP" + }, + { + "id": 134026, + "strid": "4cac2ae6-6b6e-4168-a5a5-2512b43a1067", + "image_id": 205699, + "image_name": "15626.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2276.131, + 645.972, + 233.538, + 71.69100000000003 + ], + "priority": 8, + "parents": [ + 134054 + ], + "children": [ + 134039, + 134036 + ], + "area": 1470316.8943319998, + "iscrowd": 0, + "segmentation": [], + "text": "Pipeline" + }, + { + "id": 134039, + "strid": "4df1c556-2e10-4f45-aba4-8970cd1cf9fe", + "image_id": 205699, + "image_name": "15626.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1586.877, + 730.171, + 1657.127, + 1699.369 + ], + "priority": 9, + "parents": [ + 134026 + ], + "children": [], + "area": 1158691.565967, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 134036, + "strid": "889ee442-1e8e-4dea-bbaa-a40f7b76a4f1", + "image_id": 205699, + "image_name": "15626.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1538.753, + 2447.05, + 1698.7520000000002, + 352.491 + ], + "priority": 10, + "parents": [ + 134026 + ], + "children": [], + "area": 3765405.52865, + "iscrowd": 0, + "segmentation": [], + "text": "PUMA prepares files for student analysis in various free\nbioinformatics applications - none of which require\ncommand line experience. Instructional materials and\nvideo tutorials will be provided for each tool." + }, + { + "id": 134027, + "strid": "2d6bc8f8-24ce-44e3-8c36-48de8278bebf", + "image_id": 205699, + "image_name": "15626.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3509.007, + 646.509, + 971.31, + 65.452 + ], + "priority": 11, + "parents": [ + 134054 + ], + "children": [ + 134052 + ], + "area": 2268604.606563, + "iscrowd": 0, + "segmentation": [], + "text": "Tutorials and Assessment Timeline" + }, + { + "id": 134052, + "strid": "545b2b71-bbc3-4931-b46a-44652e2bc92c", + "image_id": 205699, + "image_name": "15626.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3287.07, + 754.22, + 1467.5589999999997, + 459.9580000000001 + ], + "priority": 12, + "parents": [ + 134027 + ], + "children": [], + "area": 2479173.9354000003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 134028, + "strid": "0ce53937-d47d-469d-b703-c584b2182684", + "image_id": 205699, + "image_name": "15626.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3746.18, + 1283.237, + 554.4020000000005, + 58.82099999999991 + ], + "priority": 13, + "parents": [ + 134054 + ], + "children": [ + 134048, + 134049, + 134050, + 134051 + ], + "area": 4807236.78466, + "iscrowd": 0, + "segmentation": [], + "text": "Assessment Results" + }, + { + "id": 134051, + "strid": "c607f592-65be-4202-bded-a4bca2fa54c8", + "image_id": 205699, + "image_name": "15626.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3308.345, + 1394.292, + 1415.7800000000002, + 542.8620000000001 + ], + "priority": 14, + "parents": [ + 134028 + ], + "children": [], + "area": 4612798.966739999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 134050, + "strid": "18adb971-a9f0-4ad0-93ab-5176688f7879", + "image_id": 205699, + "image_name": "15626.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3282.373, + 1951.099, + 1459.0480000000002, + 158.6679999999999 + ], + "priority": 15, + "parents": [ + 134028 + ], + "children": [], + "area": 6404234.6779269995, + "iscrowd": 0, + "segmentation": [], + "text": "Average Ranked Responses to Sample Entry and Exit Survey Questions. In self-reported survey questions,\nstudents on average showed an improvement in confidence and assuredness in their computational biology\nskills at the end of the course. A “O” score indicates strong disagreement with the prompt or “Not at all”\nwhile a “5” score indicates strong agreement or “understand very well”" + }, + { + "id": 134048, + "strid": "517825a8-994a-4687-bdd5-8bcdfafae05c", + "image_id": 205699, + "image_name": "15626.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3283.653, + 2220.778, + 873.7509999999997, + 496.50999999999976 + ], + "priority": 16, + "parents": [ + 134028 + ], + "children": [], + "area": 7292264.342033999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 134049, + "strid": "b351cb85-3641-4333-9975-ee24e36c3597", + "image_id": 205699, + "image_name": "15626.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4175.306, + 2214.897, + 568.3320000000003, + 517.75 + ], + "priority": 17, + "parents": [ + 134028 + ], + "children": [], + "area": 9247872.733482, + "iscrowd": 0, + "segmentation": [], + "text": "Distribution of Student Scores on the\nSRBCI Pre-Test and Post-Test. The\nnumber of students plotted on the\nvertical axis is binned by the number of\ncorrect responses shown on_ the\nhorizontal axis. The pre-test scores\n(blue), is more normally distributed than\nthe post-test scores (gold). The\ndistribution of the post-test scores is\nshifted to the right, demonstrating a\nclass-wide improvement on the SRBCI,\ncorresponding to an increase of 10.5%\nfor the average of the post-test scores." + }, + { + "id": 134040, + "strid": "2167a183-3edb-4c02-a631-4e39de04195e", + "image_id": 205699, + "image_name": "15626.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1619.451, + 3056.344, + 320.1010000000001, + 333.65099999999984 + ], + "priority": 18, + "parents": [ + 134054 + ], + "children": [], + "area": 4949599.347144, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 134031, + "strid": "0758d1ad-2f40-49dc-8ea4-de8ec4ce6e4d", + "image_id": 205699, + "image_name": "15626.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1521.336, + 3433.934, + 514.819, + 125.4960000000001 + ], + "priority": 19, + "parents": [ + 134054 + ], + "children": [], + "area": 5224167.415824001, + "iscrowd": 0, + "segmentation": [], + "text": "Community profiles\nwith Excel Pivot tables" + }, + { + "id": 134037, + "strid": "97c76030-175f-4580-b0db-71d46d460d61", + "image_id": 205699, + "image_name": "15626.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2064.008, + 2867.119, + 697.5700000000002, + 127.39600000000019 + ], + "priority": 20, + "parents": [ + 134054 + ], + "children": [], + "area": 5917756.552952, + "iscrowd": 0, + "segmentation": [], + "text": "https://gauravsk.shinyapps.io/\nranacapa/" + }, + { + "id": 134041, + "strid": "cf00a1a0-7360-4ef8-9a55-806aad6f98ed", + "image_id": 205699, + "image_name": "15626.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2064.293, + 3011.583, + 687.1109999999999, + 392.57400000000007 + ], + "priority": 21, + "parents": [ + 134054 + ], + "children": [], + "area": 6216789.7058190005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 134032, + "strid": "057deafc-659c-4d84-a0bc-96a9f842ad8a", + "image_id": 205699, + "image_name": "15626.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2081.791, + 3432.508, + 656.002, + 129.7739999999999 + ], + "priority": 22, + "parents": [ + 134054 + ], + "children": [], + "area": 7145764.261828, + "iscrowd": 0, + "segmentation": [], + "text": "Data exploration in ranacapa\n(R based web app)" + }, + { + "id": 134043, + "strid": "03ab8e7c-f31b-4db8-9ddb-379c088770c1", + "image_id": 205699, + "image_name": "15626.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2868.886, + 2972.324, + 557.326, + 56.090000000000146 + ], + "priority": 23, + "parents": [ + 134054 + ], + "children": [], + "area": 8527258.711064, + "iscrowd": 0, + "segmentation": [], + "text": "OTU network demonstrates comparatively narrow spread\nof data in healthy agave among Sedgwick samples" + }, + { + "id": 134042, + "strid": "1f9f9326-75fd-4b83-b055-f60cb3f29260", + "image_id": 205699, + "image_name": "15626.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2860.154, + 3046.5, + 399.0540000000001, + 354.06899999999996 + ], + "priority": 24, + "parents": [ + 134054 + ], + "children": [], + "area": 8713459.161, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 134053, + "strid": "0d3421f1-912e-415a-8c53-bab6a84c1210", + "image_id": 205699, + "image_name": "15626.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3260.664, + 3051.264, + 177.3119999999999, + 347.10300000000007 + ], + "priority": 25, + "parents": [ + 134054 + ], + "children": [], + "area": 9949146.679296002, + "iscrowd": 0, + "segmentation": [], + "text": "OTU network of all\nSedgwick samples from\nJan. 21, 2017 shows that\nhealthy and aging agave\nshare fewer OTUs with\nother plots (narrow\ndistribution of edges)\nthan plots with an\nincreased variation in\nshared OTUs (743, 747,\n760). Image created\nusing QUIME to generate\nedge and node tables\nusing\nmake_otu_network.py\nscript and Cytoscape\nVersion 2.7.0." + }, + { + "id": 134033, + "strid": "680320c8-f542-403f-b984-9f8d64bb4703", + "image_id": 205699, + "image_name": "15626.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2837.619, + 3436.787, + 597.5329999999999, + 125.4960000000001 + ], + "priority": 26, + "parents": [ + 134054 + ], + "children": [], + "area": 9752292.090153, + "iscrowd": 0, + "segmentation": [], + "text": "OTU network visualization\nin Cytoscape" + }, + { + "id": 134047, + "strid": "dd0c6444-ebc2-4265-8e88-440c5d76b1a8", + "image_id": 205699, + "image_name": "15626.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3530.901, + 2972.559, + 608.576, + 380.98900000000003 + ], + "priority": 27, + "parents": [ + 134054 + ], + "children": [], + "area": 10495811.545659, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 134034, + "strid": "f8e049e6-adbd-4a1b-958a-9cecbbdb936a", + "image_id": 205699, + "image_name": "15626.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3620.544, + 3369.76, + 450.645, + 188.24400000000014 + ], + "priority": 28, + "parents": [ + 134054 + ], + "children": [], + "area": 12200364.349440001, + "iscrowd": 0, + "segmentation": [], + "text": "Functional pathway\nvisualization with\nKEGG and iPATH3" + }, + { + "id": 134045, + "strid": "797877a2-3ee1-475f-b796-236c4fdc7d1b", + "image_id": 205699, + "image_name": "15626.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4233.607, + 3093.657, + 203.07899999999972, + 246.44999999999982 + ], + "priority": 29, + "parents": [ + 134054 + ], + "children": [], + "area": 13097327.930799, + "iscrowd": 0, + "segmentation": [], + "text": "Shown is an Emperor\n\nPGoA plot created using\njackknifed beta diversity, with an\nunweighted (qualitative) UniFrac\nmetric, at a rarefaction value of\n30,000, Plot 748 is depicted to\nhave the highest Mg cation\nconcentration but second lowest\nCalg ratio. Findings provide\nevidence supporting community\nuniqueness for the most\nserpentine soil at the Sedgwick\nwhen compared to other,\nreduced levels of serpentine\nsoll." + }, + { + "id": 134044, + "strid": "6289b66f-49b6-4ba4-9e96-6c95450f5318", + "image_id": 205699, + "image_name": "15626.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 4441.205, + 3057.672, + 266.70899999999983, + 258.5970000000002 + ], + "priority": 30, + "parents": [ + 134054 + ], + "children": [ + 134046 + ], + "area": 13579748.17476, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 134046, + "strid": "ffb38493-969e-4bef-9897-827ea3d7b23b", + "image_id": 205699, + "image_name": "15626.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 4234.592, + 3043.192, + 181.2449999999999, + 50.52500000000009 + ], + "priority": 31, + "parents": [ + 134044 + ], + "children": [], + "area": 12886676.497663999, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 6. 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[], + "area": 198833.13046800002, + "iscrowd": 0, + "segmentation": [], + "text": "The role of timing in the heat shock effects on a prey-predator system" + }, + { + "id": 164035, + "strid": "14c94053-febf-40bd-b559-ce08343d33f0", + "image_id": 206900, + "image_name": "6609.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 3214.256, + 201.793, + 1570.0930000000003, + 185.822 + ], + "priority": 2, + "parents": [ + 164059 + ], + "children": [], + "area": 648614.361008, + "iscrowd": 0, + "segmentation": [], + "text": "Aleix Valls, James Kopco, and Jason Harmon\nDepartment of Entomology North Dakota State University" + }, + { + "id": 164036, + "strid": "6da96039-169f-43df-9db2-f62965018f9d", + "image_id": 206900, + "image_name": "6609.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 943.32, + 610.659, + 258.7790000000001, + 60.13099999999997 + ], + "priority": 3, + "parents": [ + 164059 + ], + "children": [ + 164045 + ], + "area": 576046.84788, + "iscrowd": 0, + "segmentation": [], + "text": "Abstract" + }, + { + "id": 164045, + "strid": "3a3b18d9-e5a5-4758-808a-f0f30421b0a0", + "image_id": 206900, + "image_name": "6609.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 200.295, + 738.219, + 1741.655, + 552.232 + ], + "priority": 4, + "parents": [ + 164036 + ], + "children": [], + "area": 147861.574605, + "iscrowd": 0, + "segmentation": [], + "text": "In prey-predator systems, altered abiotic factors can affect how\npredators interact with prey. We tested how the timing of a heat\nshock affects mummy production of a parasitoid wasp foraging\non pea aphids. Our results showed that the heat shock only had\nan effect when it occurred while the wasp was foraging. Before\nand after treatments did not had a significant effect on mummy\n\nproduction." + }, + { + "id": 164044, + "strid": "a63e75db-7f03-460a-a911-d9f284c570b4", + "image_id": 206900, + "image_name": "6609.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 893.599, + 1377.29, + 354.9519999999999, + 52.23000000000002 + ], + "priority": 5, + "parents": [ + 164059 + ], + "children": [ + 164058, + 164048 + ], + "area": 1230744.96671, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 164048, + "strid": "18c2c688-e31e-4179-9a2e-b95f3aec86c7", + "image_id": 206900, + "image_name": "6609.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 195.456, + 1558.265, + 1775.516, + 974.4260000000002 + ], + "priority": 6, + "parents": [ + 164044 + ], + "children": [], + "area": 304572.24384, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 164058, + "strid": "02c58e49-382a-4809-8e33-5c835634cdbd", + "image_id": 206900, + "image_name": "6609.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 531.188, + 2628.114, + 1072.241, + 805.2860000000001 + ], + "priority": 7, + "parents": [ + 164044 + ], + "children": [ + 164053 + ], + "area": 1396022.619432, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 164053, + "strid": "f7b8244b-e413-42e9-a589-74041f4140f7", + "image_id": 206900, + "image_name": "6609.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 187.697, + 3471.903, + 1774.4299999999998, + 298.5619999999999 + ], + "priority": 8, + "parents": [ + 164058 + ], + "children": [], + "area": 651665.777391, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1: Aphidius ervi foraging Pea Aphids. In order for the wasp to can carry out their life\ncycle, they need to ovoposit an egg inside an aphid. The larvae will hatch inside the body\nof the aphid and eat it from the inside. Upon completion of the development, the larva will\n\nbecome a pupa, and a new wasp will emerge." + }, + { + "id": 164037, + "strid": "2cb54221-539b-458f-bf8d-5f224d5be315", + "image_id": 206900, + "image_name": "6609.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3747.83, + 605.765, + 496.3919999999998, + 68.84299999999996 + ], + "priority": 9, + "parents": [ + 164059 + ], + "children": [ + 164046 + ], + "area": 2270304.23995, + "iscrowd": 0, + "segmentation": [], + "text": "Main Conclusion" + }, + { + "id": 164046, + "strid": "3ea6d687-82aa-4ff0-a45e-a2bc29db40f7", + "image_id": 206900, + "image_name": "6609.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2164.455, + 733.121, + 3658.7780000000002, + 161.25900000000001 + ], + "priority": 10, + "parents": [ + 164037 + ], + "children": [], + "area": 1586807.4140549998, + "iscrowd": 0, + "segmentation": [], + "text": "The heat shock had the largest effect while the wasps were foraging (during) compared to the control treatment. A heat shock during\nthis time resulted in fewer new wasps compared to the other two treatments (after and before), where the heat shock had no effect." + }, + { + "id": 164043, + "strid": "82e7c376-7693-415c-a4fb-bd371fe1a0a9", + "image_id": 206900, + "image_name": "6609.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2897.506, + 976.047, + 252.654, + 53.88000000000011 + ], + "priority": 11, + "parents": [ + 164059 + ], + "children": [ + 164049, + 164057 + ], + "area": 2828102.038782, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 164049, + "strid": "bb6f395d-ec4c-4d1e-9534-01647c238763", + "image_id": 206900, + "image_name": "6609.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2130.932, + 1141.557, + 1779.351, + 985.9460000000001 + ], + "priority": 12, + "parents": [ + 164043 + ], + "children": [], + "area": 2432580.3411239996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 164057, + "strid": "3bc0819a-568d-4204-8f7c-2b7261e13557", + "image_id": 206900, + "image_name": "6609.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2394.675, + 2236.025, + 1248.1080000000002, + 641.732 + ], + "priority": 13, + "parents": [ + 164043 + ], + "children": [ + 164054 + ], + "area": 5354553.166875001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 164054, + "strid": "82c091fd-f970-4c40-ba0c-a58dc75ff447", + "image_id": 206900, + "image_name": "6609.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2183.164, + 2910.974, + 1675.196, + 58.24299999999994 + ], + "priority": 14, + "parents": [ + 164057 + ], + "children": [], + "area": 6355133.641736001, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2: Heat shock temperature over time. X axis is daily time. Y axis Celsius degrees." + }, + { + "id": 164042, + "strid": "88cc1f57-7829-4ec5-ab21-9d8bb1b68c97", + "image_id": 206900, + "image_name": "6609.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4864.894, + 975.297, + 225.46900000000005, + 54.70900000000006 + ], + "priority": 15, + "parents": [ + 164059 + ], + "children": [ + 164056 + ], + "area": 4744716.523518001, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 164056, + "strid": "5e30168e-ba87-4785-9a0f-192be5a863b2", + "image_id": 206900, + "image_name": "6609.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 4085.671, + 1230.048, + 1844.051, + 1420.985 + ], + "priority": 16, + "parents": [ + 164042 + ], + "children": [ + 164055 + ], + "area": 5025571.4422079995, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 164055, + "strid": "b2801708-dc0e-4882-b9f3-c472d253f792", + "image_id": 206900, + "image_name": "6609.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 4089.297, + 2743.092, + 1772.4969999999998, + 218.212 + ], + "priority": 17, + "parents": [ + 164056 + ], + "children": [], + "area": 11217317.886324, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3: Mean + SE (n=218) mummy production during the three time treatments. The Y\naxis is the number of mummies divided by number of adult pea aphids present before the\n\nwasp foraged. p-values for each treatment: Before (0.71), During (0.013), and After (0.46)" + }, + { + "id": 164041, + "strid": "80109dcb-e039-4c3e-b6b5-786d54d314f6", + "image_id": 206900, + "image_name": "6609.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3836.568, + 3061.565, + 326.03300000000036, + 56.12699999999995 + ], + "priority": 18, + "parents": [ + 164059 + ], + "children": [ + 164052 + ], + "area": 11745902.308920002, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion" + }, + { + "id": 164052, + "strid": "c0b121a0-0d06-42ab-b797-27c653c419c5", + "image_id": 206900, + "image_name": "6609.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2138.246, + 3247.185, + 3726.675, + 418.1750000000002 + ], + "priority": 19, + "parents": [ + 164041 + ], + "children": [], + "area": 6943280.33751, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 164039, + "strid": "66e028c0-f1f0-44fd-9677-bf2bee5c4dba", + "image_id": 206900, + "image_name": "6609.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 6590.882, + 2109.605, + 669.0590000000002, + 77.05499999999984 + ], + "priority": 20, + "parents": [ + 164059 + ], + "children": [ + 164051 + ], + "area": 13904157.621609999, + "iscrowd": 0, + "segmentation": [], + "text": "Additional Information" + }, + { + "id": 164051, + "strid": "9ecc159c-010c-47b4-88b9-12f5e09b0c58", + "image_id": 206900, + "image_name": "6609.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 6048.421, + 2290.594, + 1757.567, + 258.76200000000017 + ], + "priority": 21, + "parents": [ + 164039 + ], + "children": [], + "area": 13854476.852074001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 164040, + "strid": "9fdd5b01-c6a7-42f2-adb6-59ca66561d29", + "image_id": 206900, + "image_name": "6609.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 6632.229, + 2596.365, + 588.2449999999999, + 73.29599999999982 + ], + "priority": 22, + "parents": [ + 164059 + ], + "children": [ + 164047 + ], + "area": 17219687.247585, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements" + }, + { + "id": 164047, + "strid": "237a903a-7fbc-44f5-8a1f-22e95b8ee6ae", + "image_id": 206900, + "image_name": "6609.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 6683.424, + 2800.326, + 1088.3339999999998, + 397.4000000000001 + ], + "priority": 23, + "parents": [ + 164040 + ], + "children": [], + "area": 18715765.996224, + "iscrowd": 0, + "segmentation": [], + "text": "| would like to thank the National Sci-\nence Foundation for their funding. Also\nthanks to Laura Manstrom, Tansy Wells\nand Courtney Garrison for their help in\nthis project." + }, + { + "id": 164038, + "strid": "c00c0a55-fdbe-4f7b-96fb-623e70393e56", + "image_id": 206900, + "image_name": "6609.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 6751.129, + 585.734, + 351.5069999999996, + 72.048 + ], + "priority": 24, + "parents": [ + 164059 + ], + "children": [ + 164050 + ], + "area": 3954365.793686, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 164050, + "strid": "b8d7a81c-bfe9-4dcf-a611-eca506e4b2f3", + "image_id": 206900, + "image_name": "6609.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 6031.618, + 761.545, + 1794.5329999999994, + 1246.763 + ], + "priority": 25, + "parents": [ + 164038 + ], + "children": [], + "area": 4593348.52981, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 84847, + "strid": "1eeebd63-d7d6-426f-a2a7-79e74a040a55", + "image_id": 203797, + "image_name": "120935.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 48.77, + 32.51, + 116.1, + 112.88 + ], + "priority": -1, + "parents": [], + "children": [ + 84825, + 84824, + 84826, + 84827, + 84829, + 84823, + 84830, + 84828 + ], + "area": 1585.5127, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 84823, + "strid": "15ac4eef-f5be-4896-9f03-e969726ea3cd", + "image_id": 203797, + "image_name": "120935.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 704.578, + 62.706, + 2330.616, + 134.425 + ], + "priority": 1, + "parents": [ + 84847 + ], + "children": [], + "area": 44181.268068, + "iscrowd": 0, + "segmentation": [], + "text": "COMPARING INFORMANT-RATED AND SELF-REPORTED FUNCTIONING\nIN THE CONTEXT OFPPERSONALIT Y PATHOLOGY" + }, + { + "id": 84824, + "strid": "e49543fd-1342-4295-a946-8ab1c856f676", + "image_id": 203797, + "image_name": "120935.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1155.488, + 247.509, + 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had regular contact\n\nto provide information-about PP’s personality and\nfunctioning." + }, + { + "id": 84826, + "strid": "6b250ef1-c560-472d-aa10-48cff01f18d0", + "image_id": 203797, + "image_name": "120935.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1248.249, + 425.512, + 204.28600000000006, + 33.67399999999998 + ], + "priority": 9, + "parents": [ + 84847 + ], + "children": [ + 84836, + 84844, + 84842, + 84835 + ], + "area": 531144.9284880001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 84835, + "strid": "2b9ccd78-a47f-466d-9aa5-32d1d5e3bfaa", + "image_id": 203797, + "image_name": "120935.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 975.132, + 506.728, + 355.446, + 41.55699999999996 + ], + "priority": 10, + "parents": [ + 84826 + ], + "children": [], + "area": 494126.688096, + "iscrowd": 0, + "segmentation": [], + "text": "Sample Characteristics" + }, + { + "id": 84844, + "strid": 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"iscrowd": 0, + "segmentation": [] + }, + { + "id": 84839, + "strid": "49c76b85-a4b4-4ce1-a512-977a4e370bb2", + "image_id": 203797, + "image_name": "120935.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2752.495, + 495.69, + 717.6530000000002, + 156.50899999999996 + ], + "priority": 21, + "parents": [ + 84846 + ], + "children": [], + "area": 1364384.24655, + "iscrowd": 0, + "segmentation": [], + "text": "Table 3\nHierarchical regression predicting\nClinician-rated BPD dimensional scores and\nDSM-5-IIIl personality functioning scores" + }, + { + "id": 84829, + "strid": "cf4326b8-9602-415e-9eb8-1659c44f5920", + "image_id": 203797, + "image_name": "120935.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2794.956, + 1494.963, + 663.3959999999997, + 34.093000000000075 + ], + "priority": 22, + "parents": [ + 84847 + ], + "children": [ + 84840, + 84841 + ], + "area": 4178355.806628, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 84840, + "strid": "526eee7e-6c0f-46a4-930e-ab491b557ddf", + "image_id": 203797, + "image_name": "120935.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2756.366, + 1550.739, + 745.808, + 493.856 + ], + "priority": 23, + "parents": [ + 84829 + ], + "children": [], + "area": 4274404.254474, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 84841, + "strid": "8601247e-58b4-4315-b021-e26cdafa103e", + "image_id": 203797, + "image_name": "120935.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2753.735, + 2069.513, + 719.0970000000002, + 202.09400000000005 + ], + "priority": 24, + "parents": [ + 84829 + ], + "children": [], + "area": 5698890.381055, + "iscrowd": 0, + "segmentation": [], + "text": "Future Directions\n\nInformant reports of functioning require further\ninvestigation, especially regarding their utility\nfor measuring Criterion A (i.e., personality\ndysfunction), PB;and other mental disorders." + }, + { + "id": 70795, + "strid": "ba512de8-1040-4d33-9a0f-7575358f7819", + "image_id": 203260, + "image_name": "119953.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 8.65, + 219.21, + 46.93, + 221.26000000000002 + ], + "priority": -1, + "parents": [], + "children": [ + 70769, + 70773, + 70772, + 70770, + 70771 + ], + "area": 1896.1665, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 70769, + "strid": "f30391a7-a954-45a4-babc-626601ec6936", + "image_id": 203260, + "image_name": "119953.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 71.991, + 31.461, + 3398.887, + 266.282 + ], + "priority": 1, + "parents": [ + 70795 + ], + "children": [], + "area": 2264.9088509999997, + "iscrowd": 0, + "segmentation": [], + "text": "Nicotiana tabacum PIN auxin carriers: identification of gene family,\nexpression profiling, localization Studies and functional testing.”" + }, + { + "id": 70770, + "strid": "5c6667af-ee8e-47b7-b660-798f4f78e442", + "image_id": 203260, + "image_name": "119953.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 93.974, + 315.458, + 3350.405, + 225.20499999999998 + ], + "priority": 2, + "parents": [ + 70795 + ], + "children": [], + "area": 29644.850092000004, + "iscrowd": 0, + "segmentation": [], + "text": "Karel Miller2, Maria Carna!, Markéta Parezova!, Katerina Malinska?, Stanislav Vosolsobé2, Eva Zazimalova? and Jan Petrasek?\n\n) IEB 1) Institute of Experimental Botany AS CR, v.v.i., Rozvojova 263, Prague 6, 165 02, Czech Republic\n\nFaculty of Science, Department of Experimental Plant Biology, Charles University in Prague, Vini¢na 5, Prague 2, 128 44, Czech Republic" + }, + { + "id": 70771, + "strid": "e6ec8037-e2b6-4940-b344-251b13e6caff", + "image_id": 203260, + "image_name": "119953.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 66.829, + 546.689, + 199.675, + 45.186000000000035 + ], + "priority": 3, + "parents": [ + 70795 + ], + "children": [ + 70776, + 70794, + 70775, + 70792, + 70774, + 70790, + 70793, + 70777, + 70778, + 70791 + ], + "area": 36534.67918099999, + "iscrowd": 0, + "segmentation": [], + "text": "Summary" + }, + { + "id": 70774, + "strid": "cb67396e-42f8-4c5a-a638-f5d1161f25e0", + "image_id": 203260, + "image_name": "119953.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 64.87, + 600.442, + 3391.199, + 296.9549999999999 + ], + "priority": 4, + "parents": [ + 70771 + ], + "children": [], + "area": 38950.67254, + "iscrowd": 0, + "segmentation": [], + "text": "Plant cell strains isolatedsfrom Nicotiana tabacum plants (BY-2, VBI-O) are frequently used to track auxin transport mechanisms at the cellular level. They allow determination of auxin transport activities) of heterologously expressed\nauxin transporters. However, information on the genes coding for endogenous, ‘tobacco auxin transporters is largely missing. Here we report on the identification of PIN auxin carrier family.from Nicotiana tabacum genome.\nSequences from bothsgenomic DNA and cDNA from Nicotiana tabacum, its ancestors Nicotiana sylvestris and Nicotiana tomentosiformis,and closely related Nicotiana benthamiana allowed us '‘to/identify and clone 9 NtP/N genes\n(Fig. 1). qRT-PCR analysis in individual plant tissues and during BY-2 cell culture growth and cell cycle revealed tissue-specific expression in plants and growth phase-specific expression in-tellculture (Fig. 2). Auxin accumulation\nassays and cellphenotyping after inducible expression of NtPINs in BY-2>cells suggested the highest auxin efflux activity for NtPIN9AFig. 3). GFP-tagged versions of NtPINs showed their prominent plasma membrane localization (Fig.\n4). Altogetherthe comparison of evidences from other species with results from NtPIN family could suggest whether the radiationvof individual Dicotyledonous families of PINs might represent the example of convergent evolution\n\nfor auxiretransport management." + }, + { + "id": 70775, + "strid": "b0724f88-899e-4538-9ee3-b33400b0083f", + "image_id": 203260, + "image_name": "119953.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 69.58, + 1012.063, + 1126.563, + 459.09900000000005 + ], + "priority": 5, + "parents": [ + 70771 + ], + "children": [], + "area": 70419.34354, + "iscrowd": 0, + "segmentation": [], + "text": "Family of PIN genes identified in Nicotiana tabacum genome and\nmolecular phylogenetic analysis of 63 ,amino acid sequences\n(Maximum Likelihood method). The analysis revealed independent\nevolution of “long” canonical PINs 1,3,4)Z% in-Arabidopsis thaliana and\nSolanaceae species, while PIN2 genes are clustered together. NtP/N8\nand NtP/N10 are not present in the analysis yet. Our results show\nrecent radiation of long PINs and’are in agreement with large scale\nphylogenetic analysis (Bennett, Marc Wilkins>, William Rawlinson??> , Maria Craig?2:4\n\n1 Virology Research, Prince of Wales Hospital Research Laboratories, South Eastern Area Laboratory Services, Prince of Wales Hospital, Sydney NSW 2031, 2School of Women’s and Children’s Health, Faculty\nof Medicine, University of New South Wales, Sydney NSW 2052, 3School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, 4Institute of Endocrinology and\nDiabetes, the Children’s Hospital at Westmead, Sydney NSW 2145, 5School of Biotechnology and Biomolecular Science, Faculty of Science, University of New South Wales, Sydney NSW 2052, NHMRC\n\nClinical Trials Centre, Sydney Medical School, University of Sydney, Sydney NSW 2006" + }, + { + "id": 13057, + "strid": "8f2c0883-5189-40ed-a71d-f9766201ffe6", + "image_id": 201025, + "image_name": "11481.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 39.722, + 1002.595, + 485.07000000000005, + 1042.543 + ], + "priority": 3, + "parents": [ + 13050 + ], + "children": [], + "area": 39825.078590000005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 13062, + "strid": "8a19c654-dfd5-4f01-b851-fb84e3322bef", + "image_id": 201025, + "image_name": "11481.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 31.357, + 2097.186, + 465.659, + 340.52599999999984 + ], + "priority": 4, + "parents": [ + 13050 + ], + "children": [], + "area": 65761.461402, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 13068, + "strid": "2074f985-66a2-4df9-a069-21325c8e776f", + "image_id": 201025, + "image_name": "11481.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 31.818, + 2469.462, + 457.147, + 262.587 + ], + "priority": 5, + "parents": [ + 13050 + ], + "children": [], + "area": 78573.341916, + "iscrowd": 0, + "segmentation": [], + "text": "Cytopathic effects CPE following\nCVB-3 infection in insulin producing\nhuman &- cells. Uninfected control\nislets and islets infected with CVB-3 at 2,\n4, and 6 days post __ infection.\nMorphological changes were seen1-2\ndays post infection when the cells\nbecame more rounded and detached\nfrom the islet cluster into the medium." + }, + { + "id": 13066, + "strid": "8c122226-1eb1-423d-9a0f-37e47974fa27", + "image_id": 201025, + "image_name": "11481.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 28.794, + 2771.871, + 486.34400000000005, + 266.15700000000015 + ], + "priority": 6, + "parents": [ + 13050 + ], + "children": [ + 13056 + ], + "area": 79813.253574, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 13056, + "strid": "e0123288-3c49-46fd-9f69-e3764a875d96", + "image_id": 201025, + "image_name": "11481.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 32.53, + 3066.546, + 479.87800000000004, + 298.7310000000002 + ], + "priority": 7, + "parents": [ + 13066 + ], + "children": [], + "area": 99754.74137999999, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 4. Effect of CVB3 and CVB5\ninfection on human insulin producing\ncells. CVB3/CVB5-infected and uninfected\ncontrol islets were harvested at 3 days\nafter infection and stained with insulin and\nvirus specific (VP1) antibodies. Infected\ncells are stained red (Alexa Fluor 594),\ninsulin stained with green (Alexa fluor 488)\nVirus-infected insulin- containing cells\nwere readily identified by their yellow color" + }, + { + "id": 13072, + "strid": "2fa9d9de-a4de-4640-a02a-d0d8fed1deca", + "image_id": 201025, + "image_name": "11481.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 34.714, + 3395.77, + 465.198, + 116.30499999999984 + ], + "priority": 8, + "parents": [ + 13050 + ], + "children": [], + "area": 117880.75978, + "iscrowd": 0, + "segmentation": [], + "text": "Australian Society of Medical\nResearch ASMR NSW\nScientific Meeting, 2014" + }, + { + "id": 13074, + "strid": "340c056d-23e0-41a7-9a98-79cd536b2442", + "image_id": 201025, + "image_name": "11481.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 525.864, + 2139.923, + 366.26099999999997, + 436.134 + ], + "priority": 9, + "parents": [ + 13050 + ], + "children": [ + 13075 + ], + "area": 1125308.468472, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 13075, + "strid": "6a93a568-48e1-441f-adb7-2b0f7c266e26", + "image_id": 201025, + "image_name": "11481.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 528.539, + 2593.535, + 350.9390000000001, + 172.9920000000002 + ], + "priority": 10, + "parents": [ + 13074 + ], + "children": [], + "area": 1370784.395365, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 6: The changes in the\nexpression level of (CAR) and\n(DAF), EV-VP1, Insulin and PdX-1\nin the infected ICAs were analysed\nwith Immuno-fluorescent staining\nusing specific antibodies" + }, + { + "id": 13070, + "strid": "3bc2fcda-b16b-47bd-b31f-c55264bc7149", + "image_id": 201025, + "image_name": "11481.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 525.956, + 2779.346, + 363.68899999999996, + 370.7629999999999 + ], + "priority": 11, + "parents": [ + 13050 + ], + "children": [ + 13061 + ], + "area": 1461813.704776, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 13061, + "strid": "140e35e4-0af9-4a09-b077-8786667983c3", + "image_id": 201025, + "image_name": "11481.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 529.072, + 3166.507, + 369.7320000000001, + 354.7840000000001 + ], + "priority": 12, + "parents": [ + 13070 + ], + "children": [], + "area": 1675310.191504, + "iscrowd": 0, + "segmentation": [], + "text": "Figure2.Up-regulated miRNA\nassociated with genes in the\nT1D protein interaction\nnetwork. The miRNAs with at least\nten-fold increase in expression\nfollowing infection of islets with\nCVB3, CVB4, or CVBS targeted 37\nT1D susceptibility genes. The protein\nproducts for 28 of these T1D\nsusceptibility genes and __ their\nphysical interaction partners form a\nhighly connected network as shown\nabove." + }, + { + "id": 13053, + "strid": "0c9a8cb5-f15e-434c-9ad2-19a5d5d9b121", + "image_id": 201025, + "image_name": "11481.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1291.162, + 1034.789, + 145.39100000000008, + 26.528999999999996 + ], + "priority": 13, + "parents": [ + 13050 + ], + "children": [ + 13054 + ], + "area": 1336080.234818, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 13054, + "strid": "d526f75b-a098-437e-9b5e-296810cc6587", + "image_id": 201025, + "image_name": "11481.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 536.906, + 1072.195, + 1651.609, + 295.3620000000001 + ], + "priority": 14, + "parents": [ + 13053 + ], + "children": [], + "area": 575667.9286699999, + "iscrowd": 0, + "segmentation": [], + "text": "Human enterovirus (HEV) infections, specifically Coxsackievirus B (CVB), demonstrate -cell tropism and are\nassociated with type 1 diabetes (T1D).\n\nPrevious studies have shown that Coxsackie-Adenovirus receptors (CAR) and Decay Accelerating Factor (DAF) are\nboth required to initiate CVB infection in human and rodent models, but this has not been examined in Human Islets-\nLike Cells Aggregates (ICAs), which are derived from human islet progenitor cells.\n\nMicroRNAs function as translational repressors and are important regulators of key biological processes, although\ntheir role in virus induced —cell death has not been examined" + }, + { + "id": 13058, + "strid": "48d0fc81-e9a2-4e2a-b99c-4cd51e3c11fe", + "image_id": 201025, + "image_name": "11481.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1277.926, + 1413.51, + 171.21000000000004, + 25.92599999999993 + ], + "priority": 15, + "parents": [ + 13050 + ], + "children": [ + 13059 + ], + "area": 1806361.1802599998, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 13059, + "strid": "16269486-b8ad-43c6-92e9-3644c1cc94f7", + "image_id": 201025, + "image_name": "11481.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 537.466, + 1450.589, + 1650.864, + 98.75600000000009 + ], + "priority": 16, + "parents": [ + 13058 + ], + "children": [], + "area": 779642.267474, + "iscrowd": 0, + "segmentation": [], + "text": "We hypothesise that (i) CBV infection of HICS is associated with up-regulation of CAR and DAF receptors and down-\nregulation of insulin and pdx-1 genes; -cell death and (ii) CVB infection of HICS alters microRNA abundance, thereby\nregulating gene expression." + }, + { + "id": 13063, + "strid": "c703deae-bdb7-4d16-a89d-355d97f3ecfc", + "image_id": 201025, + "image_name": "11481.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1293.189, + 1576.488, + 142.43399999999997, + 25.42599999999993 + ], + "priority": 17, + "parents": [ + 13050 + ], + "children": [ + 13055 + ], + "area": 2038696.940232, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 13055, + "strid": "83fc2f72-2b47-4676-8fa7-71967f0a5330", + "image_id": 201025, + "image_name": "11481.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 537.859, + 1614.82, + 1653.185, + 463.5930000000001 + ], + "priority": 18, + "parents": [ + 13063 + ], + "children": [], + "area": 868545.4703800001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 13067, + "strid": "4419fff4-2e8f-4af0-8fa7-7a3f4dc7dddf", + "image_id": 201025, + "image_name": "11481.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1276.466, + 2154.671, + 118.54199999999992, + 25.51000000000022 + ], + "priority": 19, + "parents": [ + 13050 + ], + "children": [ + 13060 + ], + "area": 2750364.2726859995, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 13060, + "strid": "dc2be39b-988e-42f5-a87d-32ce704b3b25", + "image_id": 201025, + "image_name": "11481.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 915.023, + 2190.805, + 842.3289999999998, + 732.77 + ], + "priority": 20, + "parents": [ + 13067 + ], + "children": [], + "area": 2004636.963515, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 13071, + "strid": "26e2a933-ca82-4295-93d0-6082d89dfe87", + "image_id": 201025, + "image_name": "11481.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1226.25, + 3007.452, + 200.327, + 25.802999999999884 + ], + "priority": 21, + "parents": [ + 13050 + ], + "children": [ + 13064 + ], + "area": 3687888.015, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 13064, + "strid": "0e2c6ce6-e208-4e0d-bb17-704d7b426444", + "image_id": 201025, + "image_name": "11481.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 930.194, + 3046.881, + 806.0059999999999, + 435.6709999999998 + ], + "priority": 22, + "parents": [ + 13071 + ], + "children": [], + "area": 2834190.4249139996, + "iscrowd": 0, + "segmentation": [], + "text": "COXSACKEIVIRUS B (CVBs) infection to the Human Pancreatic\nIslets and Human Islets-Like Cell Aggregates (ICAs) lead to\nDYSREGULATION of multiple DIABETES- associated microRNAs\n\nDYSREGULATION of certain DIABETES associated microRNAs will:\n(1) Disrupt the protection of cellular integrity (2) Alterations in the\nImmune Response (3) Ultimate Pancreatic-B cell DEATH\n\nThe (ICAs STEM CELLS) are a NATURAL TARGET and\nRESERVOIRE for persistent CVB infection\n\nNO Effect on the INSULIN expression level at the early stages of viral\ninfection\n\nICAs STEM CELLS are a useful CELLULAR MODEL may further our\nunderstanding of the VIRUS induced DIABETES" + }, + { + "id": 13076, + "strid": "466aa219-f06f-4e51-b044-cf71438a17d3", + "image_id": 201025, + "image_name": "11481.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1775.04, + 2149.523, + 413.9850000000001, + 882.645 + ], + "priority": 23, + "parents": [ + 13050 + ], + "children": [ + 13065 + ], + "area": 3815489.30592, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 13065, + "strid": "28713dc9-e726-4e95-97ea-1a96cec24fe3", + "image_id": 201025, + "image_name": "11481.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1764.22, + 3086.235, + 433.7270000000001, + 260.58500000000004 + ], + "priority": 24, + "parents": [ + 13076 + ], + "children": [], + "area": 5444797.511700001, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. Heat map comparing expression\nof 105 microRNAs following infection of\nislets with CVB3, CVB4 or CVB5. The\nmiRNAs are clustered based on their fold-\nchange in expression using average\nlinkage clustering. The heat map shows\n23 miRNAs that are consistently up-\nregulated in CVB3, CVB4 and CVB5\ninfected cells." + }, + { + "id": 13078, + "strid": "f4e364ce-e6b3-4dab-800e-f0519e1b5056", + "image_id": 201025, + "image_name": "11481.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2209.706, + 988.726, + 509.68499999999995, + 1022.147 + ], + "priority": 25, + "parents": [ + 13050 + ], + "children": [], + "area": 2184793.7745560003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 13077, + "strid": "bef8b234-0347-4a02-83dc-de0f9bc61940", + "image_id": 201025, + "image_name": "11481.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2196.727, + 2067.958, + 509.7040000000002, + 379.9090000000001 + ], + "priority": 26, + "parents": [ + 13050 + ], + "children": [ + 13073 + ], + "area": 4542739.173466, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 13073, + "strid": "3d965551-efce-4df9-a8bb-d2cde616cce2", + "image_id": 201025, + "image_name": "11481.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2229.252, + 2496.785, + 487.65599999999995, + 266.4540000000002 + ], + "priority": 27, + "parents": [ + 13077 + ], + "children": [], + "area": 5565962.95482, + "iscrowd": 0, + "segmentation": [], + "text": "Figure5. Effect of CVB3 and CVB5\ninfection on human insulin producing\ncells. CVB3/CVB5-infected and uninfected\ncontrol islets were harvested at 3 and 6\ndays after infection and stained with insulin\nand virus specific (VP1) antibodies. Virus-\ninfected insulin- containing cells were\nreadily identified by their yellow-orange\ncolor by using double fluorescent staining" + }, + { + "id": 13079, + "strid": "392710e4-6512-47f6-b2e5-429462331e86", + "image_id": 201025, + "image_name": "11481.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2217.846, + 2823.387, + 517.4810000000002, + 347.9209999999998 + ], + "priority": 28, + "parents": [ + 13050 + ], + "children": [ + 13069 + ], + "area": 6261837.564402, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 13069, + "strid": "e8905547-160f-498b-8485-72e87ffa5fe5", + "image_id": 201025, + "image_name": "11481.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2237.075, + 3215.642, + 486.80600000000004, + 226.6619999999998 + ], + "priority": 29, + "parents": [ + 13079 + ], + "children": [], + "area": 7193632.327149999, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3. Replication of CVBS clinical\nisolates in adult human R-cells. Floating\nislets were infected with high multiplicity\nof infection (MOI of 1/well) of CVB-2, CVB-\n3, CVB-4, and CVB-5 clinical isolate. The\nresults were shown as the mean + 95%\nconfidence intervals of three repeats." + }, + { + "id": 19763, + "strid": "afdaa5c7-e1a2-440b-bc2d-c2974a1324e0", + "image_id": 201279, + "image_name": "116867.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 19.26, + 116.5, + 66.71, + 63.599999999999994 + ], + "priority": -1, + "parents": [], + "children": [ + 19736, + 19740, + 19737, + 19738, + 19739, + 19735 + ], + "area": 2243.79, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 19735, + "strid": "34277864-55b8-4dcf-bb7f-c07e6e5e98e0", + "image_id": 201279, + "image_name": "116867.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 38.98, + 34.979, + 1575.937, + 65.469 + ], + "priority": 1, + "parents": [ + 19763 + ], + "children": [], + "area": 1363.4814199999998, + "iscrowd": 0, + "segmentation": [], + "text": "TENS Effectiveness: Have We Been Barking‘Up The Wrong RCT?" + }, + { + "id": 19736, + "strid": "8c04898c-b851-4c53-8260-3eaeecb73783", + "image_id": 201279, + "image_name": "116867.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 178.705, + 113.101, + 1297.791, + 28.147999999999996 + ], + "priority": 2, + "parents": [ + 19763 + ], + "children": [], + "area": 20211.714205, + "iscrowd": 0, + "segmentation": [], + "text": "Peter Gladwell, Specialist Physiotherapist Julie Bridson, Clinical Auditor North Bristol NHS Trust, Frenchay Hospital, Bristol, UK:" + }, + { + "id": 19737, + "strid": "fa9b7ac5-6d1e-44a6-a807-015e1ab2ccba", + "image_id": 201279, + "image_name": "116867.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 38.912, + 196.028, + 203.521, + 23.158999999999992 + ], + "priority": 3, + "parents": [ + 19763 + ], + "children": [ + 19741 + ], + "area": 7627.841536, + "iscrowd": 0, + "segmentation": [], + "text": "Aim ofiifvestigation:" + }, + { + "id": 19741, + "strid": "9264c003-fbc0-4170-bde1-2e664d9e08f3", + "image_id": 201279, + "image_name": "116867.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 39.533, + 221.811, + 279.892, + 51.647999999999996 + ], + "priority": 4, + "parents": [ + 19737 + ], + "children": [], + "area": 8768.854263000001, + "iscrowd": 0, + "segmentation": [], + "text": "To identify the types of benefit reported by long-term TENS\nSe ee ee coe\nTete a een\nin" + }, + { + "id": 19738, + "strid": "2f0d1f0c-c445-4d02-b23d-c5fecf8c6ee4", + "image_id": 201279, + "image_name": "116867.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 40.124, + 301.261, + 121.97300000000001, + 22.870000000000005 + ], + "priority": 5, + "parents": [ + 19763 + ], + "children": [ + 19742 + ], + "area": 12087.796364000002, + "iscrowd": 0, + "segmentation": [], + "text": "Background:" + }, + { + "id": 19742, + "strid": "f0c7b6bd-193d-401d-a759-fe7b5ba2afd7", + "image_id": 201279, + "image_name": "116867.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 39.642, + 327.548, + 287.562, + 172.96000000000004 + ], + "priority": 6, + "parents": [ + 19738 + ], + "children": [], + "area": 12984.657816, + "iscrowd": 0, + "segmentation": [], + "text": "Laity el tncinahl ala cthhabiaclm tly aenalna chal\nees\nSe eed\nPeano\neo ee er\neee ee eee ee)\neee te ee\neee ee eters\nSe eee\ncontrast to the reports of benefit from significant Proportion\nof people with Chronic Pain who try TENS. 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"image_name": "116867.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1324.392, + 556.598, + 287.672, + 131.85000000000002 + ], + "priority": 27, + "parents": [ + 19740 + ], + "children": [], + "area": 737153.938416, + "iscrowd": 0, + "segmentation": [], + "text": "Summary\n\nInformation fromitines who successfully use TENS machines\ncan guide the choice of sensitive outcome measures, and\nincrease the likelipood of a meaningful outcome from research,\neee ee eee\nbe explained by the focus in previous TENS trials upon pain\nBe nee\nSee eee ee ey\n\na pea onnncis Sent dyeerunashume he," + }, + { + "id": 19760, + "strid": "63c68e1c-77f7-4bec-b912-ef2df937f070", + "image_id": 201279, + "image_name": "116867.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1324.675, + 715.537, + 286.317, + 217.26800000000003 + ], + "priority": 28, + "parents": [ + 19740 + ], + "children": [], + "area": 947853.975475, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 39653, + "strid": "8ae9eb46-540d-4e3f-80e0-0e3f0b386658", + "image_id": 202058, + "image_name": "118072.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 108.69, + 323.78, + 342.29, + 187.45000000000005 + ], + "priority": -1, + "parents": [], + "children": [ + 39632, + 39633, + 39630, + 39626, + 39631, + 39629, + 39627, + 39628, + 39634 + ], + "area": 35191.648199999996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 39626, + "strid": "9a2187ac-5bf1-4220-8f4b-031583bb2062", + "image_id": 202058, + "image_name": "118072.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 508.236, + 108.583, + 2675.181, + 237.989 + ], + "priority": 1, + "parents": [ + 39653 + ], + "children": [], + "area": 55185.789588, + "iscrowd": 0, + "segmentation": [], + "text": "Clinical Pathoscope: Rapid alignment and filtration for\naccurate pathogen identification in clinical sequencing data" + }, + { + "id": 39627, + "strid": "84370d19-2c5c-45ee-9f5b-c5e9f1173d16", + "image_id": 202058, + "image_name": "118072.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1032.675, + 355.97, + 1634.4889999999998, + 210.336 + ], + "priority": 2, + "parents": [ + 39653 + ], + "children": [], + "area": 367601.31975, + "iscrowd": 0, + "segmentation": [], + "text": "Allyson Byrd’, Joseph Perez-Rogers* , Gary Benson?, W. Evan Johnson®®\n*Contributed equally\n4aProgram in Bioinformatics, Boston University, Boston, MA\n/Division of Computational-Biomedicine, Boston University School of Medicine, Boston, MA" + }, + { + "id": 39628, + "strid": "cfe9d957-7c60-46df-9f2a-351f4f566f86", + "image_id": 202058, + "image_name": "118072.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 812.029, + 774.611, + 264.5709999999999, + 56.428999999999974 + ], + "priority": 3, + "parents": [ + 39653 + ], + "children": [ + 39635 + ], + "area": 629006.595719, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 39635, + "strid": "09b567b1-c941-424d-a57f-daf28c87e4e9", + "image_id": 202058, + "image_name": "118072.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 120.427, + 877.953, + 1644.382, + 897.8040000000001 + ], + "priority": 4, + "parents": [ + 39628 + ], + "children": [], + "area": 105729.245931, + "iscrowd": 0, + "segmentation": [], + "text": "The rapid and accurate identification of pathogens in human tissue samples has become a\nnecessity as novel disease-causing pathogens emerge and as existing pathogens increasingly\ndevelop resistance to broad spectrum antibiotics. With the increased affordability of mRNA\nsequencing, it is possible to investigate the microbiome of a given sample; however, clinical\nsamples contain a mixture of genomic sequences from various sources that complicates the\nidentification of pathogens. Here we present Clinical Pathoscope, a pipeline to rapidly and\naccurately remove host contamination, isolate microbial reads, and identify potential disease-\ncausing pathogens. To optimize the Clinical Pathoscope pipeline, data was simulated from\nhuman, bacterial, and viral genomes to create biologically realistic clinical samples. that\nrepresented a variety of host-pathogen landscapes. These data were then used to evaluate the\naccuracy, usability, and speed of multiple alignment algorithms and filtration methods. The\noptimal alignment algorithm and filtration methods were used to isolate microbial reads. These\nreads were then mapped against a robust pathogen database and assigned to their appropriate\ngenomes. Unique to other methods, Clinical Pathoscope can identify multiple pathogens from\nmixed samples and distinguish between very closely related species with very little coverage of\nthe genome and without the need for genome assembly. We demonstrate our approach using\nreal and simulated sequencing samples from children with respiratory tract infections, an HPV\ncell line, and a monkey with a novel adenovirus subtype." + }, + { + "id": 39630, + "strid": "0806bf7d-1db9-4294-9c08-771bfd676961", + "image_id": 202058, + "image_name": "118072.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 751.744, + 1871.212, + 385.04599999999994, + 60.57899999999995 + ], + "priority": 5, + "parents": [ + 39653 + ], + "children": [ + 39645, + 39644, + 39636 + ], + "area": 1406672.393728, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 39636, + "strid": "597130e7-eb96-43af-8ee4-d8154230ec5e", + "image_id": 202058, + "image_name": "118072.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 126.867, + 1975.632, + 1666.928, + 147.31899999999996 + ], + "priority": 6, + "parents": [ + 39630 + ], + "children": [], + "area": 250642.50494400001, + "iscrowd": 0, + "segmentation": [], + "text": "Goal\nTo rapidly and accurately identify all species, strains, and substrains present in a given sequencing\nsample" + }, + { + "id": 39644, + "strid": "33ed140b-4d4c-44b8-92b7-a0824b6c4e40", + "image_id": 202058, + "image_name": "118072.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 122.073, + 2141.395, + 1450.918, + 149.21799999999985 + ], + "priority": 7, + "parents": [ + 39630 + ], + "children": [], + "area": 261406.51183499998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 39645, + "strid": "ab12ba48-2cdb-461a-801d-ac5c0f983951", + "image_id": 202058, + "image_name": "118072.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 122.487, + 2314.26, + 1615.72, + 247.82400000000007 + ], + "priority": 8, + "parents": [ + 39630 + ], + "children": [], + "area": 283466.76462000003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 39631, + "strid": "8ea4770f-d1e1-45d0-b703-ede5563bca59", + "image_id": 202058, + "image_name": "118072.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 582.959, + 2662.915, + 725.524, + 59.621000000000095 + ], + "priority": 9, + "parents": [ + 39653 + ], + "children": [ + 39649, + 39650 + ], + "area": 1552370.2654849999, + "iscrowd": 0, + "segmentation": [], + "text": "Materials and Methods" + }, + { + "id": 39649, + "strid": "b6c18c6e-05c8-4a30-a3c8-5e3cf9602faa", + "image_id": 202058, + "image_name": "118072.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 125.609, + 2757.195, + 1638.537, + 571.4789999999998 + ], + "priority": 10, + "parents": [ + 39631 + ], + "children": [ + 39638 + ], + "area": 346328.506755, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 39638, + "strid": "bb08bd67-1c90-4719-a891-4ff6963c151b", + "image_id": 202058, + "image_name": "118072.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 125.15, + 3362.51, + 1635.058, + 195.57000000000016 + ], + "priority": 11, + "parents": [ + 39649 + ], + "children": [], + "area": 420818.1265000001, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1: A) Reference databases were collected from NCBI’s RefSeq. B) in silico samples were simulated to represent a\nvariety of clinical scenarios using the Mason [1] next-generation sequencing read simulator. C) Four read alignment\nalgorithms [2-5] were optimized by aligning the simulated data to each of the databases and varying the parameters. D)\nSee Figure 2. E) Using three clinical datasets [6-8], the final pipeline was tested, evaluated, and compared with the latest\npathogen identification methods, RINS and ReadScan [9,10]." + }, + { + "id": 39650, + "strid": "f0c998d8-9191-4922-83dc-b29904eb741e", + "image_id": 202058, + "image_name": "118072.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 125.808, + 3577.833, + 1265.499, + 802.989 + ], + "priority": 12, + "parents": [ + 39631 + ], + "children": [ + 39639 + ], + "area": 450120.01406400005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 39639, + "strid": "d8178f71-e7fc-4d6b-ae22-74de30628535", + "image_id": 202058, + "image_name": "118072.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 130.386, + 4404.073, + 1621.805, + 197.97800000000007 + ], + "priority": 13, + "parents": [ + 39650 + ], + "children": [], + "area": 574229.462178, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2: Using the optimal aligner, various filtration methods were tested in an effort to minimize computation burden\nand maximize accuracy. Approaches tested include A) Naive Approach, B) Target Centric, C) Target Centric +\nReassignment, D) Host Centric + Reassignment, and E) Host Centric. Post filtration, all reads are aligned against the\ntarget genome library. The resulting read alignments are reassigned to the correct genome of origin using an\nExpectation Maximization algorithm as described previously." + }, + { + "id": 39629, + "strid": "0fc01cef-5ddb-4e30-a34f-f5d19aecd9f1", + "image_id": 202058, + "image_name": "118072.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2645.938, + 772.34, + 221.51299999999992, + 60.986999999999966 + ], + "priority": 14, + "parents": [ + 39653 + ], + "children": [ + 39651, + 39652, + 39637, + 39647, + 39648 + ], + "area": 2043563.7549200002, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 39648, + "strid": "3aabeaba-7ea1-49b0-8d8d-72c962badd27", + "image_id": 202058, + "image_name": "118072.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1937.7, + 873.894, + 813.2610000000002, + 595.424 + ], + "priority": 15, + "parents": [ + 39629 + ], + "children": [ + 39643 + ], + "area": 1693344.4038, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 39643, + "strid": "f90b6f4d-690c-4dbe-92b0-7c37588d9150", + "image_id": 202058, + "image_name": "118072.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2801.633, + 1002.758, + 740.4850000000001, + 155.89200000000005 + ], + "priority": 16, + "parents": [ + 39648 + ], + "children": [], + "area": 2809359.903814, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1: The average time, sensitivity, and specificity\nfor each aligner when run with optimal parameters on\nthe simulated sequencing samples (100bp, 10 million\nreads) for each of the databases." + }, + { + "id": 39637, + "strid": "b7bfea7d-930f-4c0a-a5da-8266de085045", + "image_id": 202058, + "image_name": "118072.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2804.354, + 1205.655, + 731.6109999999999, + 270.78700000000003 + ], + "priority": 17, + "parents": [ + 39629 + ], + "children": [], + "area": 3381083.4218699997, + "iscrowd": 0, + "segmentation": [], + "text": "Bowtie2 demonstrated the best combination of\naccuracy and rapid run time for each of the databases\nand was therefore implemented for each alignment\nstep.\n\nBWA failed to run to completion with the bacterial\ndatabase." + }, + { + "id": 39652, + "strid": "bf075910-1e3d-4e0e-8a76-2f2a550191e7", + "image_id": 202058, + "image_name": "118072.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1923.557, + 1532.343, + 1440.9400000000003, + 967.488 + ], + "priority": 18, + "parents": [ + 39629 + ], + "children": [ + 39642 + ], + "area": 2947549.104051, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 39642, + "strid": "b30aa420-e087-4a9d-a9b0-a474f2625bee", + "image_id": 202058, + "image_name": "118072.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1964.171, + 2545.774, + 1458.582, + 78.3130000000001 + ], + "priority": 19, + "parents": [ + 39652 + ], + "children": [], + "area": 5000335.463354, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3: A computational subtraction method using varying sequence read lengths and an ambiguous read\nreassignment algorithm based on a Bayesian statistical framework [9]." + }, + { + "id": 39647, + "strid": "10945983-d0ed-4621-a37e-572925119f9f", + "image_id": 202058, + "image_name": "118072.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1923.931, + 2684.043, + 1601.5229999999997, + 388.029 + ], + "priority": 20, + "parents": [ + 39629 + ], + "children": [ + 39641 + ], + "area": 5163913.533033, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 39641, + "strid": "19b3aab3-919a-408a-85f2-591765c8108e", + "image_id": 202058, + "image_name": "118072.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1964.422, + 3098.724, + 1558.58, + 117.78200000000015 + ], + "priority": 21, + "parents": [ + 39647 + ], + "children": [], + "area": 6087201.597528, + "iscrowd": 0, + "segmentation": [], + "text": "Table 2: Across a range of read lengths and varying levels of genome converage, Clinical Pathoscope was able to\nsuccessfully decode the viral composition of a given sample in under 20 minutes, compared to an hour or more for\nother approaches." + }, + { + "id": 39651, + "strid": "b465cd8a-d5f5-400c-9663-90f334185917", + "image_id": 202058, + "image_name": "118072.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1917.95, + 3226.972, + 1033.296, + 579.5349999999999 + ], + "priority": 22, + "parents": [ + 39629 + ], + "children": [ + 39640 + ], + "area": 6189170.947400001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 39640, + "strid": "f3f22ea4-ed60-4242-9cd5-816f9940714d", + "image_id": 202058, + "image_name": "118072.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2830.86, + 3374.985, + 717.6349999999998, + 317.0619999999999 + ], + "priority": 23, + "parents": [ + 39651 + ], + "children": [], + "area": 9554110.0371, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 4: To evaluate the ability to differentiate a\nhighly mutated virus, Clinical Pathoscope was tested\nona sample from a titi monkey infected with a novel\nadenovirus strain (ECC-2011, TmAdv) [4]. When the\nviral database does not include the TmAdv strain,\nreads map to closely related adenovirus strains.\nWhen the database does include the strain, all reads\nare reassigned to the correct viral genome." + }, + { + "id": 39634, + "strid": "3a007912-8eaa-461d-9b2a-f913bcf2d83c", + "image_id": 202058, + "image_name": "118072.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2571.642, + 3915.626, + 368.529, + 60.01899999999978 + ], + "priority": 24, + "parents": [ + 39653 + ], + "children": [ + 39646 + ], + "area": 10069588.277892, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 39646, + "strid": "5ab7b155-5c80-43f4-8a9b-a8d692c742d2", + "image_id": 202058, + "image_name": "118072.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1935.675, + 4006.049, + 1334.0909999999997, + 445.21900000000005 + ], + "priority": 25, + "parents": [ + 39634 + ], + "children": [], + "area": 7754408.898074999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 39632, + "strid": "3489805b-02b9-43ae-8521-6c3bc7d8022f", + "image_id": 202058, + "image_name": "118072.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 636.688, + 4685.665, + 613.2509999999999, + 71.98099999999977 + ], + "priority": 26, + "parents": [ + 39653 + ], + "children": [], + "area": 2983306.67752, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements" + }, + { + "id": 39633, + "strid": "69c9a71d-6ee4-4f92-ba38-1f7f522803ad", + "image_id": 202058, + "image_name": "118072.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2582.403, + 4536.967, + 346.78200000000015, + 61.38299999999981 + ], + "priority": 27, + "parents": [ + 39653 + ], + "children": [], + "area": 11716277.191700999, + "iscrowd": 0, + "segmentation": [], + "text": "Yah aaa" + }, + { + "id": 146419, + "strid": "36e6920c-1dd3-4ac1-8522-a9e8c99bff63", + "image_id": 206184, + "image_name": "18711.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 51.75, + 140.47, + 210.14, + 173.35999999999999 + ], + "priority": -1, + "parents": [], + "children": [ + 146384, + 146397, + 146414, + 146418, + 146386, + 146402, + 146383, + 146391, + 146401 + ], + "area": 7269.3225, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 146383, + "strid": "773c7170-b310-4d30-a83c-12bf28c31a07", + "image_id": 206184, + "image_name": "18711.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 69.887, + 82.298, + 2466.553, + 127.856 + ], + "priority": 1, + "parents": [ + 146419 + ], + "children": [], + "area": 5751.560326, + "iscrowd": 0, + "segmentation": [], + "text": "R interface to the Reactome Graph Database" + }, + { + "id": 146384, + "strid": "2ea020df-53a4-4beb-af8f-48647a28172b", + "image_id": 206184, + "image_name": "18711.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 67.223, + 234.127, + 3148.451, + 157.156 + ], + "priority": 2, + "parents": [ + 146419 + ], + "children": [], + "area": 15738.719321, + "iscrowd": 0, + "segmentation": [], + "text": "Chi-Lam Poon', Justin Cook2, Solomon Shorser?, Joel Weiser?, Robin Haw? and Lincoln Stein?\n\n'Weill Cornell Medicine, New York, NY, USA; 2Simon Fraser University, Burnaby, BC, Canada; ?Ontario Institute for Cancer Research, Toronto, ON, Canada" + }, + { + "id": 146386, + "strid": "3ea13059-4e7e-4b28-8235-a6b92c90528e", + "image_id": 206184, + "image_name": "18711.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 658.557, + 471.193, + 305.82400000000007, + 59.073999999999955 + ], + "priority": 3, + "parents": [ + 146419 + ], + "children": [ + 146385 + ], + "area": 310307.448501, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 146385, + "strid": "0916743f-29f8-4c33-b4c7-28d5e198e917", + "image_id": 206184, + "image_name": "18711.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 56.569, + 551.103, + 1526.28, + 570.024 + ], + "priority": 4, + "parents": [ + 146386 + ], + "children": [], + "area": 31175.345607, + "iscrowd": 0, + "segmentation": [], + "text": "Reactome is a knowledgebase of biomolecular pathways. As of the current release, its\nholdings comprise 13,827 human reactions organized into 2,536 pathways involving 11,084\nproteins, 1,857 small molecules, and 432 drugs, with the support of 33,752 literature\nreferences. These molecular entity and event annotations are systematically represented as\nan ordered network of molecular reactions, naturally forming a graph of biological\nknowledge. Reactome has migrated from a relational database to a Neo4j graph database for\nefficient storage, processing, and access with these highly interconnected data. To minimize\nthe usage of Neo4j Cypher, we developed an interface, ReactomeGraph4R, for interacting\nbetween R and the Reactome graph database. We developed a second R package,\nReactomeContentService4R, to wrap the RESTful API of the Content Service built on top of the\ngraph core. These packages are available through Bioconductor and fulfill the needs of omics\nanalyses with Reactome knowledge." + }, + { + "id": 146402, + "strid": "705d1b42-9fd6-4280-8017-246b88a7062f", + "image_id": 206184, + "image_name": "18711.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 473.616, + 1555.539, + 691.364, + 66.31799999999998 + ], + "priority": 5, + "parents": [ + 146419 + ], + "children": [ + 146409, + 146403, + 146405, + 146408, + 146406, + 146407, + 146404 + ], + "area": 736728.1590239999, + "iscrowd": 0, + "segmentation": [], + "text": "Fetching Reactome Instances" + }, + { + "id": 146403, + "strid": "ee2f6f76-5438-45f9-8c61-c3cbdb831309", + "image_id": 206184, + "image_name": "18711.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 57.471, + 1646.726, + 1540.234, + 378.01199999999994 + ], + "priority": 6, + "parents": [ + 146402 + ], + "children": [], + "area": 94638.989946, + "iscrowd": 0, + "segmentation": [], + "text": "Basically, ReactomeGraph4R retrieves data with a network structure by translating R\ncommands to Cypher queries and communicating with a local Graph Database.\nReactomeContentService4R retrieves specific bits of information through\nconstructing and sending http requests to the Content Service. Returned data are formatted\nas R objects in the two packages.\n\nFor example, to fetch details of a protein \"misfolded CFTR [endoplasmic reticulum\nmembrane]\" with standard id R-HSA-886 8730 (a common functionality in both packages):" + }, + { + "id": 146404, + "strid": "266850eb-193d-48c7-973f-8499c59cad39", + "image_id": 206184, + "image_name": "18711.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 67.419, + 2069.503, + 553.755, + 43.10699999999997 + ], + "priority": 7, + "parents": [ + 146402 + ], + "children": [], + "area": 139523.82275700002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 146405, + "strid": "37ccc0ff-1ee7-4645-a46f-0d1b6986f938", + "image_id": 206184, + "image_name": "18711.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 117.157, + 2129.189, + 1430.809, + 391.27599999999984 + ], + "priority": 8, + "parents": [ + 146402 + ], + "children": [], + "area": 249449.39567299996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 146406, + "strid": "a2b9c61b-e557-4abe-82f1-a9a007eab4fe", + "image_id": 206184, + "image_name": "18711.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 55.813, + 2543.676, + 1056.113, + 155.8470000000002 + ], + "priority": 9, + "parents": [ + 146402 + ], + "children": [], + "area": 141970.188588, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 146407, + "strid": "c8a70a35-a3ed-46ea-8aa3-5b87378c9dd0", + "image_id": 206184, + "image_name": "18711.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 59.129, + 2742.63, + 775.92, + 36.47499999999991 + ], + "priority": 10, + "parents": [ + 146402 + ], + "children": [], + "area": 162168.96927, + "iscrowd": 0, + "segmentation": [], + "text": "o ReactomeContentService4R function:" + }, + { + "id": 146408, + "strid": "9ff38b12-0471-4f66-aa52-ea1ca15ca6fc", + "image_id": 206184, + "image_name": "18711.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 95.604, + 2808.948, + 958.2939999999999, + 477.48900000000003 + ], + "priority": 11, + "parents": [ + 146402 + ], + "children": [], + "area": 268546.66459199996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 146409, + "strid": "291a3726-b971-48c5-8ed7-6f1d907bac79", + "image_id": 206184, + "image_name": "18711.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 62.445, + 3289.753, + 1442.415, + 193.98000000000002 + ], + "priority": 12, + "parents": [ + 146402 + ], + "children": [], + "area": 205428.626085, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 146391, + "strid": "5de50788-5a1d-49ec-89f2-5d0847eba326", + "image_id": 206184, + "image_name": "18711.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1925.497, + 471.327, + 932.7529999999999, + 57.78099999999995 + ], + "priority": 13, + "parents": [ + 146419 + ], + "children": [ + 146398, + 146399, + 146400, + 146387, + 146390, + 146389, + 146388 + ], + "area": 907538.724519, + "iscrowd": 0, + "segmentation": [], + "text": "Fetching preceding/following Reactions" + }, + { + "id": 146387, + "strid": "c207bf6e-0df8-432b-9780-ca29e9e72de7", + "image_id": 206184, + "image_name": "18711.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1632.464, + 559.375, + 1535.328, + 189.85199999999998 + ], + "priority": 14, + "parents": [ + 146391 + ], + "children": [], + "area": 913159.5499999999, + "iscrowd": 0, + "segmentation": [], + "text": "Events are building blocks in the database and they have two subclasses, Pathways and\nReactionLikeEvents. Pathways are ordered groups of Reations/ReactionLikeEvents.\nReactomeGraph4R:matchPrecedingAndFollowingEvents() can get preceding\nand following Reactions of a Reaction of interest via the “precedingEvent” relationship." + }, + { + "id": 146388, + "strid": "85dac651-adf9-4c7f-88a9-4cd9a0edafce", + "image_id": 206184, + "image_name": "18711.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1642.094, + 772.615, + 1528.449, + 127.94399999999996 + ], + "priority": 15, + "parents": [ + 146391 + ], + "children": [], + "area": 1268706.45581, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 146389, + "strid": "deb0b3de-e848-4c9f-b15f-fab6c4a23ba1", + "image_id": 206184, + "image_name": "18711.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1688.87, + 922.571, + 1132.2349999999997, + 323.29899999999986 + ], + "priority": 16, + "parents": [ + 146391 + ], + "children": [], + "area": 1558102.48477, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 146390, + "strid": "fa08d1fb-decb-4bcc-be49-0cb1bbc26892", + "image_id": 206184, + "image_name": "18711.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1637.967, + 1289.893, + 1151.496, + 41.271999999999935 + ], + "priority": 17, + "parents": [ + 146391 + ], + "children": [], + "area": 2112802.167531, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 146398, + "strid": "267c78e4-50aa-4cbc-b171-8f9642429170", + "image_id": 206184, + "image_name": "18711.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1690.573, + 1350.23, + 1174.294, + 144.125 + ], + "priority": 18, + "parents": [ + 146391 + ], + "children": [], + "area": 2282662.38179, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 146399, + "strid": "f779c7f2-810a-4adf-9fa9-fc6ff502a9c6", + "image_id": 206184, + "image_name": "18711.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1642.47, + 1537.302, + 774.262, + 674.7850000000001 + ], + "priority": 19, + "parents": [ + 146391 + ], + "children": [], + "area": 2524972.4159399997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 146400, + "strid": "b7a2fdfa-5383-4bcb-84c7-82f4a877253b", + "image_id": 206184, + "image_name": "18711.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2476.418, + 1535.644, + 654.8890000000001, + 666.4950000000001 + ], + "priority": 20, + "parents": [ + 146391 + ], + "children": [], + "area": 3802896.443192, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 146401, + "strid": "adc47266-07f5-4d1a-a21e-b2213e621299", + "image_id": 206184, + "image_name": "18711.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2202.856, + 2265.141, + 389.61799999999994, + 64.65999999999985 + ], + "priority": 21, + "parents": [ + 146419 + ], + "children": [ + 146411, + 146410, + 146412 + ], + "area": 4989779.442696, + "iscrowd": 0, + "segmentation": [], + "text": "Finding Referrals" + }, + { + "id": 146410, + "strid": "29fb6e22-c758-4703-91f5-cb9b7b4e44b7", + "image_id": 206184, + "image_name": "18711.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1634.18, + 2349.696, + 1528.628, + 185.69000000000005 + ], + "priority": 22, + "parents": [ + 146401 + ], + "children": [], + "area": 3839826.20928, + "iscrowd": 0, + "segmentation": [], + "text": "PhysicalEntities are participants of Reactions (Pathway > Reaction > PhysicalEntity). Using\nReactomeGraph4R: :matchReferrals() we can get Referrals of a given object (= find\ninstances in a reverse direction). For instance, to enumerate the Reactions that have\nDefinedSets (a PhysicalEntity subgroup):" + }, + { + "id": 146411, + "strid": "cb2ab6b8-9864-40b3-b2ea-9509392961b0", + "image_id": 206184, + "image_name": "18711.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1677.287, + 2555.282, + 1137.352, + 379.6700000000001 + ], + "priority": 23, + "parents": [ + 146401 + ], + "children": [], + "area": 4285941.279934, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 146412, + "strid": "c5fa3c21-2102-48b5-b29f-a0023fa13207", + "image_id": 206184, + "image_name": "18711.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1751.894, + 2953.189, + 1266.6719999999998, + 537.1749999999997 + ], + "priority": 24, + "parents": [ + 146401 + ], + "children": [], + "area": 5173674.089966, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 146397, + "strid": "bc78a979-9eba-4040-afd2-cc0d80d11a29", + "image_id": 206184, + "image_name": "18711.png", + "category_id": 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"image_name": "18711.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3280.865, + 709.855, + 1035.0820000000003, + 101.543 + ], + "priority": 27, + "parents": [ + 146397 + ], + "children": [], + "area": 2328938.424575, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 146394, + "strid": "28927b72-3315-4145-a7f9-e92707b575b0", + "image_id": 206184, + "image_name": "18711.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3731.256, + 817.949, + 566.6740000000004, + 527.368 + ], + "priority": 28, + "parents": [ + 146397 + ], + "children": [], + "area": 3051977.1139439996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 146393, + "strid": "ac107ea2-a4a3-47b3-9511-0ed30d99fc17", + "image_id": 206184, + "image_name": "18711.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3282.502, + 1358.418, + 958.1060000000002, + 70.42499999999995 + ], + "priority": 29, + "parents": [ + 146397 + ], + "children": [], + "area": 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"18711.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3207.494, + 1902.05, + 1525.7069999999999, + 108.55600000000004 + ], + "priority": 32, + "parents": [ + 146418 + ], + "children": [], + "area": 6100813.9627, + "iscrowd": 0, + "segmentation": [], + "text": "Non-Reactome identifiers, e.g. UniProt ids, gene symbols, GO terms, associated with an Event\n(Pathway or Reaction) can be retrieved by ReactomeContentService4R::event2Ids()." + }, + { + "id": 146416, + "strid": "349c3fc2-cf49-481b-b0b7-fa21a3a9039c", + "image_id": 206184, + "image_name": "18711.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3284.47, + 2020.475, + 1087.5350000000003, + 481.59400000000005 + ], + "priority": 33, + "parents": [ + 146418 + ], + "children": [], + "area": 6636189.52325, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 146415, + "strid": "ba306423-3e2e-4224-80fc-dc8f03bdfc07", + "image_id": 206184, + "image_name": "18711.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3217.363, + 2535.624, + 1527.681, + 90.79199999999992 + ], + "priority": 34, + "parents": [ + 146418 + ], + "children": [], + "area": 8158022.839511999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 146414, + "strid": "d7e34f5c-25d0-45cf-907f-87f2c14a181a", + "image_id": 206184, + "image_name": "18711.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3738.432, + 3001.428, + 463.83100000000013, + 61.18600000000015 + ], + "priority": 35, + "parents": [ + 146419 + ], + "children": [ + 146413 + ], + "area": 11220634.480896, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements" + }, + { + "id": 146413, + "strid": "a0db01b6-2da4-4af6-9588-1673b93238a3", + "image_id": 206184, + "image_name": "18711.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3205.52, + 3090.247, + 1531.6280000000002, + 201.32200000000012 + ], + "priority": 36, + "parents": [ + 146414 + ], + "children": [], + "area": 9905848.563439999, + "iscrowd": 0, + "segmentation": [], + "text": "This work was funded by Google Summer of Code, 2020. The development of Reactome is\nsupported by grants from the US National Institutes of Health (U41 HG003751) and the\n\nEuropean Molecular Biology Laboratory. We thank the event support made possible by the\nfellowship from Open Bioinformatics Foundation (OBF)." + }, + { + "id": 98624, + "strid": "85b3f5f6-7489-46df-9eb8-96ce07e1d2fd", + "image_id": 204316, + "image_name": "121867.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 10.97, + 68.98, + 201.15, + 174.32999999999998 + ], + "priority": -1, + "parents": [], + "children": [ + 98607, + 98615, + 98598, + 98604, + 98588, + 98599, + 98613, + 98589, + 98592, + 98622, + 98597, + 98616, + 98621, + 98587, + 98586 + ], + "area": 756.7106000000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 98616, + "strid": "b2a7d144-3e61-47aa-8338-de2ce92cd1b8", + "image_id": 204316, + "image_name": "121867.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 260.514, + 101.403, + 2661.219, + 124.14200000000001 + ], + "priority": 1, + "parents": [ + 98624 + ], + "children": [], + "area": 26416.901142000002, + "iscrowd": 0, + "segmentation": [], + "text": "Illumina — NextBio Body Atlas Now Features RNA-segq Data" + }, + { + "id": 98615, + "strid": "44aeafd9-5e6d-484f-8cc0-f93ff436fc8e", + "image_id": 204316, + "image_name": "121867.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 554.931, + 299.655, + 2076.33, + 92.226 + ], + "priority": 2, + "parents": [ + 98624 + ], + "children": [], + "area": 166287.848805, + "iscrowd": 0, + "segmentation": [], + "text": "Eugene Bolotin, Chenxi Chen, Apoorva Dhabalia and Jane Su" + }, + { + "id": 98586, + "strid": "cc274e8e-7d1a-4fb2-8070-8f92a8ea475b", + "image_id": 204316, + "image_name": "121867.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 290.65, + 479.665, + 282.24799999999993, + 65.62100000000004 + ], + "priority": 3, + "parents": [ + 98624 + ], + "children": [ + 98585 + ], + "area": 139414.63225, + "iscrowd": 0, + "segmentation": [], + "text": "Abstract" + }, + { + "id": 98585, + "strid": "7156c530-1d9a-4b2c-a05c-989019280969", + "image_id": 204316, + "image_name": "121867.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 91.717, + 627.95, + 715.782, + 1148.687 + ], + "priority": 4, + "parents": [ + 98586 + ], + "children": [], + "area": 57593.69015, + "iscrowd": 0, + "segmentation": [], + "text": "We have incorporated RNA-seq data into NextBio BodyAtlas\n(https://enterprise.nextbio.com) to allow easy browsing of\ngene expression signatures for 50 tissues derived from\nGenotype Tissue Expression Project (GTEx).\n\nWe achieved this by downloading 729 raw SRA files from\nGTEx database, assessed the data quality through several\nsoftware packages such as: FASTQC to access the read\nquality and RSeQC to assess levels of RNA-degradation. We\nthen aligned the data using Illumina RNAExpress 1.0 pipeline\n(STAR aligner followed by manta counter).\n\nCount quality was accessed by pairwise correlation and\nhierarchical clustering. Samples that had between-tissue\ncorrelation greater than within-tissue correlation were\nremoved, as well as samples which had < 10*10%6 aligned\nreads.\n\nOverall we excluded 224 samples that failed one or more\ncriteria from a total of 729 samples used. Interestingly, while\nmost tissues displayed high level RNA degradation, the\ndegradation was not correlated to levels of gene expression.\nWe then used edgeR for TMM normalization, followed by\ndifferential comparison between each tissue vs all tissues\n(excluding comparison tissue).\n\nWe used ranked differential P-values in NextBio Research\nScoring App to rank the tissue specificity of genes between\ntissues.\n\nUsing ranked P-values as a signature, 47/50 tissues closely\nmatched the signature of the existing NextBio Affymetrix Array\nbased Body Atlas thus validating our approach. BodyAtlas\nRNA-seq should be useful for scientific community for its\nability to query this dataset by tissue, gene, gene signature\n(bioset), or pathway (biogroup)." + }, + { + "id": 98587, + "strid": "4bb5dec8-2f9e-4717-91c3-b6042404c597", + "image_id": 204316, + "image_name": "121867.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1034.615, + 490.437, + 382.84199999999987, + 63.34299999999996 + ], + "priority": 5, + "parents": [ + 98624 + ], + "children": [ + 98595, + 98594 + ], + "area": 507413.476755, + "iscrowd": 0, + "segmentation": [], + "text": "Query by Gene" + }, + { + "id": 98594, + "strid": "441b622d-4564-44ba-81b0-dc8741fe71fc", + "image_id": 204316, + "image_name": "121867.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 901.341, + 636.995, + 664.811, + 826.726 + ], + "priority": 6, + "parents": [ + 98587 + ], + "children": [], + "area": 574149.710295, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 98595, + "strid": "f0e37217-76f7-4773-8398-b8640c206c07", + "image_id": 204316, + "image_name": "121867.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 953.353, + 1562.429, + 562.3930000000001, + 123.27999999999997 + ], + "priority": 7, + "parents": [ + 98587 + ], + "children": [], + "area": 1489546.374437, + "iscrowd": 0, + "segmentation": [], + "text": "Screenshot of NextBio research gene\nview. This screenshot shows an\nexample of tissue query by gene." + }, + { + "id": 98588, + "strid": "4a8b3783-89f5-4753-aabb-207d8e69d6cc", + "image_id": 204316, + "image_name": "121867.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1698.654, + 490.569, + 695.5250000000001, + 65.61600000000004 + ], + "priority": 8, + "parents": [ + 98624 + ], + "children": [ + 98596, + 98593 + ], + "area": 833306.994126, + "iscrowd": 0, + "segmentation": [], + "text": "Query by Gene List (bioset)" + }, + { + "id": 98593, + "strid": "5b67cf34-596e-4229-8ee3-2e8303bdb7dd", + "image_id": 204316, + "image_name": "121867.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1656.699, + 636.669, + 748.1060000000002, + 833.6240000000001 + ], + "priority": 9, + "parents": [ + 98588 + ], + "children": [], + "area": 1054768.895631, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 98596, + "strid": "5aca5df3-3767-4be5-aa43-ba5df6b4dcb5", + "image_id": 204316, + "image_name": 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Green solid\nblocks are separate tissues. Red streaks are poorly correlated samples. 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It\nappears that abundance of\nmuscle tissue genes are the\nreason for 3 mismatched tissues." + }, + { + "id": 98601, + "strid": "68115d3b-01e6-49d8-b048-0dd069090131", + "image_id": 204316, + "image_name": "121867.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2437.031, + 2524.037, + 637.7420000000002, + 359.2359999999999 + ], + "priority": 29, + "parents": [ + 98599 + ], + "children": [], + "area": 6151156.414147, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 98617, + "strid": "0848030d-b2a5-4a26-a9fc-7fa1bc5d2ab3", + "image_id": 204316, + "image_name": "121867.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2025.167, + 2932.534, + 917.2719999999999, + 79.86799999999994 + ], + "priority": 30, + "parents": [ + 98599 + ], + "children": [], + "area": 5938871.083178, + "iscrowd": 0, + "segmentation": [], + "text": "Esophagus Pathways are enriched for muscle genes in RNA-\nseq" + }, + { + "id": 98618, + "strid": "3d128bb8-2287-4478-8fcd-ae93136d050f", + "image_id": 204316, + "image_name": "121867.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2029.489, + 3020.354, + 1033.79, + 55.320000000000164 + ], + "priority": 31, + "parents": [ + 98599 + ], + "children": [], + "area": 6129775.219106, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 98619, + "strid": "bd892a07-2256-4b04-82d0-aee28cc2ed22", + "image_id": 204316, + "image_name": "121867.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2027.876, + 3100.741, + 980.9469999999999, + 78.6579999999999 + ], + "priority": 32, + "parents": [ + 98599 + ], + "children": [], + "area": 6287918.256116, + "iscrowd": 0, + "segmentation": [], + "text": "Myometrium + Saphenous vein are also enriched in muscle genes\nin Array" + }, + { + "id": 98620, + "strid": "d0e585a7-ef27-4a86-b9e2-c3b0f54c4a8a", + "image_id": 204316, + "image_name": "121867.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2021.709, + 3196.687, + 1078.7369999999999, + 54.45600000000013 + ], + "priority": 33, + "parents": [ + 98599 + ], + "children": [], + "area": 6462770.878083, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 98604, + "strid": "e4d032dc-223c-477b-b90c-51bbef079a8d", + "image_id": 204316, + "image_name": "121867.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2204.708, + 3292.72, + 730.1550000000002, + 65.53999999999996 + ], + "priority": 34, + "parents": [ + 98624 + ], + "children": [ + 98605, + 98606 + ], + "area": 7259486.12576, + "iscrowd": 0, + "segmentation": [], + "text": "Male vs Female Comparison" + }, + { + "id": 98605, + "strid": "79c64160-44aa-4e3b-b300-08b407af0595", + "image_id": 204316, + "image_name": "121867.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1977.215, + 3412.505, + 1137.5620000000001, + 462.02999999999975 + ], + "priority": 35, + "parents": [ + 98604 + ], + "children": [], + "area": 6747256.073575, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 98606, + "strid": "ad675e15-0d09-4fe9-8720-bf3872a8d940", + "image_id": 204316, + "image_name": "121867.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2245.359, + 3882.204, + 884.221, + 62.79100000000017 + ], + "priority": 36, + "parents": [ + 98604 + ], + "children": [], + "area": 8716941.691236, + "iscrowd": 0, + "segmentation": [], + "text": "Large numbers of clinically relevant genes are differentially expressed between\nmale and female tissues." + }, + { + "id": 98621, + "strid": "5fcb9de9-7e2d-4fc1-9057-324d82c8bdb4", + "image_id": 204316, + "image_name": "121867.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 446.099, + 4019.695, + 305.78400000000005, + 53.22499999999991 + ], + "priority": 37, + "parents": [ + 98624 + ], + "children": [ + 98623 + ], + "area": 1793181.919805, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion" + }, + { + "id": 98623, + "strid": "3e14f08c-543d-4f4e-8246-b927ded176d7", + "image_id": 204316, + "image_name": "121867.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 295.985, + 4130.151, + 796.141, + 122.73400000000038 + ], + "priority": 38, + "parents": [ + 98621 + ], + "children": [], + "area": 1222462.743735, + "iscrowd": 0, + "segmentation": [], + "text": "NextBio Research Body Atlas is easy to use and comprehensive\nsolution for investigating tissue specific gene expression, and\ndeveloping in-depth understanding of your own datasets. 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"category_name": "List", + "bbox": [ + 576.43, + 687.093, + 174.06600000000003, + 98.64700000000005 + ], + "priority": 26, + "parents": [ + 182317 + ], + "children": [], + "area": 396061.01798999996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 182319, + "strid": "424bf126-9152-47b6-8ced-53b3354cf101", + "image_id": 207618, + "image_name": "8503.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 628.809, + 807.688, + 77.41200000000003, + 13.744000000000028 + ], + "priority": 27, + "parents": [ + 182339 + ], + "children": [ + 182335 + ], + "area": 507881.483592, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 182335, + "strid": "a39a7e48-a764-4ab0-8ef0-7ff778fb70e4", + "image_id": 207618, + "image_name": "8503.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 581.544, + 844.701, + 146.19500000000005, + 124.12800000000004 + ], + "priority": 28, + "parents": [ + 182319 + ], + "children": [], + "area": 491230.798344, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 138280, + "strid": "38a9720b-01aa-4086-8b1f-ffa60c3e813a", + "image_id": 205860, + "image_name": "16480.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 3250.37, + 26.36, + 57.63000000000011, + 261.8 + ], + "priority": -1, + "parents": [], + "children": [ + 138253, + 138252, + 138256, + 138257, + 138251, + 138255, + 138254 + ], + "area": 85679.75319999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 138251, + "strid": "1c78747d-08ba-41e2-a7af-a45facccfb00", + "image_id": 205860, + "image_name": "16480.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 38.28, + 30.039, + 3204.948, + 239.35200000000003 + ], + "priority": 1, + "parents": [ + 138280 + ], + "children": [], + "area": 1149.89292, + "iscrowd": 0, + "segmentation": [], + "text": "The database of Spanish population variability: a\ncrowdsourcing resource for collecting local genomic data" + }, + { + "id": 138252, + "strid": "ebde0eca-afa6-4961-b747-44ef187b3cb9", + "image_id": 205860, + "image_name": "16480.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 41.806, + 294.947, + 3224.584, + 543.227 + ], + "priority": 2, + "parents": [ + 138280 + ], + "children": [], + "area": 12330.554282, + "iscrowd": 0, + "segmentation": [], + "text": "Maria Pena-Chilet'23, Gema Roldan’, Javier Pérez-Florido'2:+, Francisco M. Ortufho!2, Rosario Carmona’,\nVirginia Aquino-Quintans', Daniel L6pez-Lé6pez'2, Arcadi Navarro>®7®, Jose L. Fernandez-Rueda! and\nJoaquin Dopazo!23;5\n\nClinical Bioinformatics Area, Fundacion Progreso y Salud. Seville, Spain. 2?Computational Systems Medicine, Institute of Biomedicine of Seville (IBIS), 41013.\nSevilla. Soain. Centre for Biomedical Research in Rare Diseases (CIBERER). Seville, Spain. “Virgen del Rocio University Hospital. Andalusian Health System.\nSeville, Soain. ° National Institute for Bioinformatics, INB-ELIXIR-es, Spain. Department of Experimental and Health Sciences, IBE, Institute of Evolutionary\nBiology, (Universitat Pompeu Fabra -CSIC), Barcelona, Catalonia, Spain. 7Centre for Genomic Regulation (CRG), Barcelona, Catalonia, Spain. ®Institucio\nCatalana de Recerca i Estudis Avan¢ats (ICREA), Barcelona, Catalonia, Spain. WT ACiinianzAlBiain‘g\n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\na" + }, + { + "id": 138253, + "strid": "7a4f4d47-718f-4745-87b7-65b15b84f857", + "image_id": 205860, + "image_name": "16480.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 124.395, + 950.927, + 528.398, + 55.64499999999998 + ], + "priority": 3, + "parents": [ + 138280 + ], + "children": [ + 138279, + 138258 + ], + "area": 118290.564165, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 138258, + "strid": "1c914fb4-f592-4cc2-b649-0e7b689dff65", + "image_id": 205860, + "image_name": "16480.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 115.983, + 1026.452, + 1531.869, + 545.6760000000002 + ], + "priority": 4, + "parents": [ + 138253 + ], + "children": [], + "area": 119050.98231600001, + "iscrowd": 0, + "segmentation": [], + "text": "Results from large-scale genomic projects suggest that allele\nfrequencies, which are highly relevant for medical purposes, differ\nconsiderably across different populations. The need for a detailed catalog\nof local variability motivated the creation of a Spanish population\nvariant server web tool. The Collaborative Spanish Variant Server\n(CSVS) is a catalog created as a free tool to provide information about the\nvariability of the Spanish population to the scientific and medical\ncommunity. Its usefulness for filtering polymorphisms and local\nvariations in the process of prioritizing candidate disease genes has been\nalready proven (1). Currently, CSVS stores information on 1942 unrelated\nSpanish individuals." + }, + { + "id": 138279, + "strid": "ef50fce5-cdd0-400c-a387-405f2fdf4c3e", + "image_id": 205860, + "image_name": "16480.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 119.747, + 1589.173, + 1519.696, + 44.534000000000106 + ], + "priority": 5, + "parents": [ + 138253 + ], + "children": [], + "area": 190298.699231, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 138254, + "strid": "e868a154-a776-44a7-ba67-eb1f1a548acb", + "image_id": 205860, + "image_name": "16480.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1724.574, + 950.484, + 543.9699999999998, + 56.43500000000006 + ], + "priority": 6, + "parents": [ + 138280 + ], + "children": [ + 138269 + ], + "area": 1639179.9938160002, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 138269, + "strid": "31b31df1-94ff-4330-bac5-a24f109a64de", + "image_id": 205860, + "image_name": "16480.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1712.296, + 1042.79, + 1488.883, + 591.3409999999999 + ], + "priority": 7, + "parents": [ + 138254 + ], + "children": [], + "area": 1785565.14584, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 138255, + "strid": "0eab17f9-9c05-4c40-b732-1ac57a2b0775", + "image_id": 205860, + "image_name": "16480.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 141.433, + 1725.673, + 731.695, + 57.74000000000001 + ], + "priority": 8, + "parents": [ + 138280 + ], + "children": [ + 138272, + 138271, + 138262, + 138261, + 138260, + 138273, + 138270, + 138259 + ], + "area": 244067.109409, + "iscrowd": 0, + "segmentation": [], + "text": "CURRENTLY ON CSVS" + }, + { + "id": 138259, + "strid": "4ab8ba09-3889-4825-ada5-38a96ca962c8", + "image_id": 205860, + "image_name": "16480.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 160.225, + 1833.93, + 814.964, + 317.193 + ], + "priority": 9, + "parents": [ + 138255 + ], + "children": [], + "area": 293841.43425, + "iscrowd": 0, + "segmentation": [], + "text": "Data in CSVS\n\nCurrently there are 1942 unrelated Spanish\nindividuals, among healthy controls, healthy\nindividuals with an affected relative, and\naffected individuals with no relatives in CSVS,\nthat can be used as pseudocontrols. Total number\nof variants reported in CSVS are 33,178,913, from\n324 genomes, 1,562 exomes and 56 panels." + }, + { + "id": 138270, + "strid": "ec7804e6-604f-4cc2-9f3f-ce9525ed0b66", + "image_id": 205860, + "image_name": "16480.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1038.347, + 1843.679, + 733.758, + 359.71500000000015 + ], + "priority": 10, + "parents": [ + 138255 + ], + "children": [], + "area": 1914378.558613, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 138260, + "strid": "b5ca2792-a40f-4785-8a4f-a9eb6a1d3feb", + "image_id": 205860, + "image_name": "16480.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 158.404, + 2239.451, + 626.264, + 487.9569999999999 + ], + "priority": 11, + "parents": [ + 138255 + ], + "children": [], + "area": 354737.99620399997, + "iscrowd": 0, + "segmentation": [], + "text": "Genes saturation\n\nThe genes in CSVS are most of them\nsaturated in variants, however, there\nis a different saturation rate among\ngenes, most saturated genes are\nrelated to GO terms meiosis, cell\nsignaling and __ proliferation, ion\ntransport or homeostasis. While least\nsaturated genes are enriched in\nsensory perception processes, neuron\ndifferentiation, defense and antiviral\nresponse, among others." + }, + { + "id": 138271, + "strid": "53a9427b-2610-44b1-902d-da199f827d69", + "image_id": 205860, + "image_name": "16480.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 801.103, + 2244.763, + 1027.9559999999997, + 503.80499999999984 + ], + "priority": 12, + "parents": [ + 138255 + ], + "children": [], + "area": 1798286.3735889997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 138261, + "strid": "d0e61630-d9cf-4be3-a182-1b2ffc2a59fb", + "image_id": 205860, + "image_name": "16480.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1894.486, + 1842.582, + 507.45900000000006, + 480.135 + ], + "priority": 13, + "parents": [ + 138255 + ], + "children": [], + "area": 3490745.8028520006, + "iscrowd": 0, + "segmentation": [], + "text": "Pathogenic variants\n\nOf the pathogenic variants\nfrom ClinVar, 514 were found\nin CSVS control population, of\nthose 165 were not present in\n1000Genomes European\npopulation and 57 have a\nfrequency more than 2-fold\nincreased. On the right, 24\nvariants with CSVS frequency\nhigher than 0.01 are\nrepresented." + }, + { + "id": 138272, + "strid": "9e4961e9-e1d7-4b42-beeb-e52fabd3e2a0", + "image_id": 205860, + "image_name": "16480.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2428.031, + 1845.732, + 729.1170000000002, + 436.5079999999998 + ], + "priority": 14, + "parents": [ + 138255 + ], + "children": [], + "area": 4481494.513692, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 138262, + "strid": "1d4c7f10-f2a7-4108-9868-61680f4904d0", + "image_id": 205860, + "image_name": "16480.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1912.659, + 2361.765, + 676.9810000000002, + 354.8090000000002 + ], + "priority": 15, + "parents": [ + 138255 + ], + "children": [], + "area": 4517251.083135, + "iscrowd": 0, + "segmentation": [], + "text": "Pharmacogenetic variants\n\nSome of the pharmacogenetic variants\nhave different frequencies in Spanish\npopulation when compared with\n1000Genomes EUR population. The\ncorrelation between frequencies — is\nrepresented on the right, the associated\ndrug is shown only for those variants with\nhigher differences." + }, + { + "id": 138273, + "strid": "ce8a9e24-86f2-4bce-be9e-c9b0ee2a5959", + "image_id": 205860, + "image_name": "16480.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2616.179, + 2310.439, + 553.511, + 422.1289999999999 + ], + "priority": 16, + "parents": [ + 138255 + ], + "children": [], + "area": 6044521.992581, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 138256, + "strid": "edb48300-9f22-49a3-8153-6999b29ae01a", + "image_id": 205860, + "image_name": "16480.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 145.261, + 2871.397, + 543.346, + 56.815000000000055 + ], + "priority": 17, + "parents": [ + 138280 + ], + "children": [ + 138274, + 138264, + 138263, + 138278, + 138276, + 138265, + 138266, + 138267, + 138277, + 138275 + ], + "area": 417101.999617, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 138277, + "strid": "319d5b2b-1b8e-4c2f-964e-356038848476", + "image_id": 205860, + "image_name": "16480.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 158.115, + 2979.086, + 390.009, + 68.26699999999983 + ], + "priority": 18, + "parents": [ + 138256 + ], + "children": [], + "area": 471038.18289, + "iscrowd": 0, + "segmentation": [], + "text": "Pathopedia" + }, + { + "id": 138274, + "strid": "be9af058-cfac-4b83-9f60-1bbb7e6ba006", + "image_id": 205860, + "image_name": "16480.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 175.861, + 3036.649, + 841.149, + 491.95199999999977 + ], + "priority": 19, + "parents": [ + 138256 + ], + "children": [], + "area": 534028.1297889999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 138263, + "strid": "46b1479c-475d-4597-be2d-83022ee96c24", + "image_id": 205860, + "image_name": "16480.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1035.32, + 3062.677, + 340.8799999999999, + 417.2359999999999 + ], + "priority": 20, + "parents": [ + 138256 + ], + "children": [], + "area": 3170850.75164, + "iscrowd": 0, + "segmentation": [], + "text": "Pathopedia — stores\nclinical significance\ninformation about\neach variant, and\nallows the user to\nadd a new review\nand categorize a\nvariant as benign,\nlikely benign, likely\npathogenic and\npathogenic." + }, + { + "id": 138264, + "strid": "29d88197-e344-4e6b-a1bc-1e07e2bda665", + "image_id": 205860, + "image_name": "16480.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1469.274, + 2976.76, + 740.1129999999998, + 508.4380000000001 + ], + "priority": 21, + "parents": [ + 138256 + ], + "children": [], + "area": 4373676.07224, + "iscrowd": 0, + "segmentation": [], + "text": "Beacon\n\nCSVS makes its genomic information\ndiscoverable through the GA4GH Beacon\nnetwork (https://beacon-network.org/).\n\nIn order to improve the performance of the\nCSVS Beacon API we set up an SQLite\ndatabase specific for this purpose.\n\nCSVS stores data in 1-base but can respond to\nqueries in both 1-base or O-base (Beacon\nrequests data in O-base). A form to make\ndirectly Bacon-style queries is also available\nat http://ucscbeacon.clinbioinfosspa.es/." + }, + { + "id": 138275, + "strid": "5b2d3ae7-9937-45f4-b7fd-34fd99157003", + "image_id": 205860, + "image_name": "16480.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2261.942, + 2990.212, + 113.39499999999998, + 522.4859999999999 + ], + "priority": 22, + "parents": [ + 138256 + ], + "children": [], + "area": 6763686.111704, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 138265, + "strid": "47485015-fc2c-4a84-b3f5-6d1d3c35f69c", + "image_id": 205860, + "image_name": "16480.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 160.029, + 3617.724, + 2064.19, + 121.4989999999998 + ], + "priority": 23, + "parents": [ + 138256 + ], + "children": [], + "area": 578940.753996, + "iscrowd": 0, + "segmentation": [], + "text": "Quality controls\n\nIn order to guarantee the reliability of the data in CSVS we are implementing identity controls without compromising privacy." + }, + { + "id": 138267, + "strid": "f0e62a3c-ddf3-46da-8f5a-48ddd985a129", + "image_id": 205860, + "image_name": "16480.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 175.547, + 3755.281, + 2174.088, + 151.1170000000002 + ], + "priority": 24, + "parents": [ + 138256 + ], + "children": [], + "area": 659228.313707, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 138278, + "strid": "3f192ec6-d413-42d5-86fa-ef8e7073b5fb", + "image_id": 205860, + "image_name": "16480.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2505.787, + 2967.115, + 554.4580000000001, + 64.1289999999999 + ], + "priority": 25, + "parents": [ + 138256 + ], + "children": [], + "area": 7434958.194504999, + "iscrowd": 0, + "segmentation": [], + "text": "Request contact" + }, + { + "id": 138276, + "strid": "5408b853-45b4-46d4-83df-7f1a1b8583b4", + "image_id": 205860, + "image_name": "16480.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2533.428, + 3049.512, + 588.6179999999999, + 572.489 + ], + "priority": 26, + "parents": [ + 138256 + ], + "children": [], + "area": 7725719.087136, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 138266, + "strid": "5ff08e60-f72b-46e6-bdf0-08cfa77f2af1", + "image_id": 205860, + "image_name": "16480.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2529.658, + 3670.724, + 607.8710000000001, + 226.59900000000016 + ], + "priority": 27, + "parents": [ + 138256 + ], + "children": [], + "area": 9285676.332392, + "iscrowd": 0, + "segmentation": [], + "text": "Request contact is a new feature\nthat allows the user of CSVS to\ncontact the person/institution, via a\ncentralized service, that submitted\nthe data in which a given variant is\nreported." + }, + { + "id": 138257, + "strid": "54d2319e-74d2-4635-9cb1-7ac879d64177", + "image_id": 205860, + "image_name": "16480.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 132.881, + 4048.985, + 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148494, + "strid": "c16472b3-02a2-433c-9af7-7e59057a22fa", + "image_id": 206267, + "image_name": "19257.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 193.033, + 107.924, + 2750.35, + 293.63200000000006 + ], + "priority": 1, + "parents": [ + 148514 + ], + "children": [], + "area": 20832.893492, + "iscrowd": 0, + "segmentation": [], + "text": "Landscaping prognostic gene expression and anticancer targets\nusing sample- and lineage-consensus scores derived\nfrom pan-cancer omics data" + }, + { + "id": 148495, + "strid": "d14d40ae-e797-4d0c-97e9-6a9061fe6007", + "image_id": 206267, + "image_name": "19257.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 974.303, + 444.202, + 1190.257, + 52.43399999999997 + ], + "priority": 2, + "parents": [ + 148514 + ], + "children": [], + "area": 432787.341206, + "iscrowd": 0, + "segmentation": [], + "text": "Youngju Kim, Jieun Lee, Euna Jeong, and Sukjoon Yoon*" + }, + { + "id": 148497, + "strid": "1fb1f0a7-ab91-4514-9fc9-10373afbc95c", + "image_id": 206267, + "image_name": "19257.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1485.055, + 579.313, + 180.471, + 43.98000000000002 + ], + "priority": 3, + "parents": [ + 148514 + ], + "children": [ + 148496 + ], + "area": 860311.667215, + "iscrowd": 0, + "segmentation": [], + "text": "Abstract" + }, + { + "id": 148496, + "strid": "6e0747cb-c56d-4bfa-8d42-131675b2db69", + "image_id": 206267, + "image_name": "19257.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 13.592, + 642.287, + 3105.272, + 404.9089999999999 + ], + "priority": 4, + "parents": [ + 148497 + ], + "children": [], + "area": 8729.964904, + "iscrowd": 0, + "segmentation": [], + "text": "Integration of large scale multi-omics data enables extensive analysis of cross-associated data pairs between collateral datasets such as mutation, RNA/protein expression, RNAi/drug screen, clinical information, etc. Here, we\ninvestigated the reproducibility of the significance in the association by measuring sample consensus and/or lineage consensus for given data pairs (gene expression vs. patient survival, gene expression vs. RNAi efficacy). The\nsample consensus score represents the number of significant (p<0.01) cases in the associations for a given data pair among varied sample groups within a lineage, while the lineage consensus score is the significant cases among\ndiverse lineages. ~74% of prognostic gene expression (i.e., gene expression associated with patient survival) were exclusively found in a single lineage, while only ~1.8% prognostic genes showed the significance in over three different\nlineages (consensus score >3). In case of sample consensus, common prognostic genes between genders were less than exclusive genes between them. However, prognostic genes with high sample consensus score generally\nexhibited high lineage consensus scores, implying that consensus scoring might improve the reproducibility of predicted prognostic gene expression in other cohort or cancer lineages. Furthermore, the lineage consensus score for\nthe association between sgRNA (CRISPR) efficacy and RNA expression could predict the association between shRNA and RNA expression. This study suggests that consensus scoring help smart data mining prioritizing true-positives\n\nfor the further validation. The concept of consensus scoring has been implemented in Q-omics software (http://qomics.sookmyung.ac.kr) for analyzing associations between diverse cancer omics data." + }, + { + "id": 148498, + "strid": "a099b1cb-a175-4804-8614-7d463f1d8fa7", + "image_id": 206267, + "image_name": "19257.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1207.496, + 1078.51, + 741.7240000000002, + 50.26099999999997 + ], + "priority": 5, + "parents": [ + 148514 + ], + "children": [ + 148503, + 148500, + 148499, + 148502, + 148501 + ], + "area": 1302296.51096, + "iscrowd": 0, + "segmentation": [], + "text": "I. Data mining for survival analysis" + }, + { + "id": 148499, + "strid": "00fbbff6-ecae-411e-bfb6-acfa26e8094a", + "image_id": 206267, + "image_name": "19257.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 65.864, + 1162.64, + 520.374, + 475.0450000000001 + ], + "priority": 6, + "parents": [ + 148498 + ], + "children": [], + "area": 76576.12096000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 148500, + "strid": "66c28d57-70b2-46cc-8a9b-25e330cbe2be", + "image_id": 206267, + "image_name": "19257.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 622.501, + 1164.453, + 538.5060000000001, + 462.35300000000007 + ], + "priority": 7, + "parents": [ + 148498 + ], + "children": [], + "area": 724873.156953, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 148501, + "strid": "d7250faf-4079-424c-bdb6-5d6585bdf57c", + "image_id": 206267, + "image_name": "19257.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 83.995, + 1679.388, + 1006.2980000000001, + 427.904 + ], + "priority": 8, + "parents": [ + 148498 + ], + "children": [], + "area": 141060.19506, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 148502, + "strid": "06dba799-36cf-4334-af14-d3f566d5bd8b", + "image_id": 206267, + "image_name": "19257.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1144.688, + 1175.332, + 1151.351, + 930.146 + ], + "priority": 9, + "parents": [ + 148498 + ], + "children": [], + "area": 1345388.4364160001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 148503, + "strid": "0fc7111c-83cd-45c5-b259-f5291570654c", + "image_id": 206267, + "image_name": "19257.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2357.686, + 1240.606, + 741.5790000000002, + 737.952 + ], + "priority": 10, + "parents": [ + 148498 + ], + "children": [], + "area": 2924959.397716, + "iscrowd": 0, + "segmentation": [], + "text": "We performed a large-scale analysis using\npublic data to find new prognostic gene expression\nand anticancer targets for diverse cancers. Moreover,\nwe defined the favorable and unfavorable prognostic\ngene expression. Favorable prognostic gene\nexpression is a lower survival rate in the group with\nlow gene expression, and unfavorable prognostic gene\nexpression is a lower survival rate in the group with\nhigh gene expression. Distribution of prognostic gene\nexpression shows that there is difference in the\nnumber depending on the cancer lineage. In addition,\nlow gender consensus was confirmed by the large\ndifference between gender-common and overall\nprognostic gene. Therefore, we analyzed sample- and\n\nlineage-consensus." + }, + { + "id": 148504, + "strid": "97e180fb-fd16-4278-9226-da989c3edc31", + "image_id": 206267, + "image_name": "19257.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1208.011, + 2132.982, + 736.81, + 49.820000000000164 + ], + "priority": 11, + "parents": [ + 148514 + ], + "children": [ + 148507, + 148506, + 148505 + ], + "area": 2576665.718802, + "iscrowd": 0, + "segmentation": [], + "text": "II. Sample- and lineage-consensus" + }, + { + "id": 148507, + "strid": "bc194716-1e15-4c5c-9135-5dafef22ffd2", + "image_id": 206267, + "image_name": "19257.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 13.656, + 2211.895, + 1349.308, + 851.6129999999998 + ], + "priority": 12, + "parents": [ + 148504 + ], + "children": [], + "area": 30205.63812, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 148505, + "strid": "e3492340-ed25-4c1b-9eb8-a9ec7acc955f", + "image_id": 206267, + "image_name": "19257.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1552.859, + 2254.764, + 1446.317, + 439.61799999999994 + ], + "priority": 13, + "parents": [ + 148504 + ], + "children": [], + "area": 3501330.570276, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 148506, + "strid": "93d6a258-9af2-4a05-bcb2-37c3529c161a", + "image_id": 206267, + "image_name": "19257.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1441.003, + 2756.813, + 1680.4329999999998, + 288.74299999999994 + ], + "priority": 14, + "parents": [ + 148504 + ], + "children": [], + "area": 3972575.803439, + "iscrowd": 0, + "segmentation": [], + "text": "A consensus scoring method was used to preferentially select data with high experimental validation success rates.\nThe \"Sample Consensus Score\" is derived by iteratively calculating the significance (p-value) of the correlation between gene\nexpression and patient survival in a specific cancer type through various sampling methods, and the significance of several\nother cancer lineages is derived from the \"Lineage consensus score\". we compared the two consensus scores. The two\nconsensus scores were highly correlated. This means that the predictability is high, and we thought this was an indicator that\n\ncould increase the experimental success rate." + }, + { + "id": 148508, + "strid": "93dce7c4-e625-4568-882f-c9f21de15dac", + "image_id": 206267, + "image_name": "19257.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 396.013, + 3090.367, + 742.594, + 55.30000000000018 + ], + "priority": 15, + "parents": [ + 148514 + ], + "children": [ + 148509 + ], + "area": 1223825.506771, + "iscrowd": 0, + "segmentation": [], + "text": "I. Validation of consensus scoring" + }, + { + "id": 148509, + "strid": "282199dd-cd30-4fe7-9b31-9a90c1f31196", + "image_id": 206267, + "image_name": "19257.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 72.116, + 3174.106, + 1433.048, + 680.9740000000002 + ], + "priority": 16, + "parents": [ + 148508 + ], + "children": [], + "area": 228903.82829600002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 148513, + "strid": "b70f0e7c-84fa-4088-8065-fa5a254e09e4", + "image_id": 206267, + "image_name": "19257.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2152.28, + 3090.593, + 376.94000000000005, + 49.65700000000015 + ], + "priority": 17, + "parents": [ + 148514 + ], + "children": [ + 148512, + 148511 + ], + "area": 6651821.502040001, + "iscrowd": 0, + "segmentation": [], + "text": "Q-omics software" + }, + { + "id": 148511, + "strid": "4fce3da0-7f16-43ea-bec1-2728bb6dd100", + "image_id": 206267, + "image_name": "19257.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1625.242, + 3161.692, + 308.097, + 487.53899999999976 + ], + "priority": 18, + "parents": [ + 148513 + ], + "children": [], + "area": 5138514.6294639995, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 148512, + "strid": "50821419-e7b2-41e0-9426-12e5f37dd28f", + "image_id": 206267, + "image_name": "19257.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1973.968, + 3163.949, + 663.5939999999998, + 492.0529999999999 + ], + "priority": 19, + "parents": [ + 148513 + ], + "children": [], + "area": 6245534.079632, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 148510, + "strid": "1b380d8e-d0c1-4680-933c-057d90d45161", + "image_id": 206267, + "image_name": "19257.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1615.762, + 3682.862, + 1469.387, + 143.779 + ], + "priority": 20, + "parents": [ + 148514 + ], + "children": [], + "area": 5950628.470844, + "iscrowd": 0, + "segmentation": [], + "text": "O Reference\nQ-omics: Smart Software for Assisting Oncology and Cancer Research, Jieun Lee, Youngju Kim, Seonghee Jin,\n\nHeeseing Yoo, Sumin Jeong, Euna Jeong and Sukjoon Yoon, Molecules and Cells, 2021 Nov 30;44(11):843-\n850." + }, + { + "id": 107641, + "strid": "68767a7c-6217-49ea-92f3-664aa03a1554", + "image_id": 204668, + "image_name": "12747.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 25.76, + 20.58, + 168.11, + 36.77 + ], + "priority": -1, + "parents": [], + "children": [ + 107630, + 107640, + 107629, + 107633, + 107632, + 107631 + ], + "area": 530.1408, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 107629, + "strid": "a0101a2e-820b-4059-be31-111992370fe6", + "image_id": 204668, + "image_name": "12747.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 52.992, + 92.672, + 1407.775, + 328.134 + ], + "priority": 1, + "parents": [ + 107641 + ], + "children": [], + "area": 4910.874624, + "iscrowd": 0, + "segmentation": [], + "text": "Sensitive dataset\naccess manage eal" + }, + { + "id": 107640, + "strid": "4ddfa2b7-193f-4cb4-89a7-c1cf2b25f3b5", + "image_id": 204668, + "image_name": "12747.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 466.17, + 3003.747, + 398.137, + 206.23000000000002 + ], + "priority": 2, + "parents": [ + 107641 + ], + "children": [], + "area": 1400256.73899, + "iscrowd": 0, + "segmentation": [], + "text": "Authors\n\nMikael Linden, ELIXIR-FI\nTommi Jalkanen, ELIXIR-FI\nJuha Térnroos, ELIXIR-FI" + }, + { + "id": 107633, + "strid": "8c46f1bf-b660-4671-9775-9961eb95bf1c", + "image_id": 204668, + "image_name": "12747.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 60.175, + 549.651, + 2184.824, + 101.11900000000003 + ], + "priority": 3, + "parents": [ + 107641 + ], + "children": [], + "area": 33075.24892499999, + "iscrowd": 0, + "segmentation": [], + "text": "The ELIXIR human data community and the ELIXIR AAI task have developed an architecture for managing user’s access\nrights to sensitive datasets and enforcing the access rights in the computing environment." + }, + { + "id": 107630, + "strid": "36a31417-5cdd-4a8f-9332-968790c0cbed", + "image_id": 204668, + "image_name": "12747.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 61.209, + 718.822, + 748.6959999999999, + 61.222999999999956 + ], + "priority": 4, + "parents": [ + 107641 + ], + "children": [ + 107636 + ], + "area": 43998.375798, + "iscrowd": 0, + "segmentation": [], + "text": "|. Applying for access to datasets" + }, + { + "id": 107636, + "strid": "1c85511b-b60f-41e5-b31d-f341aaaa99e4", + "image_id": 204668, + "image_name": "12747.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 76.695, + 812.314, + 1021.377, + 554.228 + ], + "priority": 5, + "parents": [ + 107630 + ], + "children": [], + "area": 62300.42222999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 107631, + "strid": "5163b85c-3b44-4e53-94cf-f373c0df0230", + "image_id": 204668, + "image_name": "12747.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1253.874, + 719.899, + 845.3839999999998, + 57.14200000000005 + ], + "priority": 6, + "parents": [ + 107641 + ], + "children": [ + 107637 + ], + "area": 902662.638726, + "iscrowd": 0, + "segmentation": [], + "text": "Il. Enforcing dataset access in a cloud" + }, + { + "id": 107637, + "strid": "d3123423-64e6-4add-83d1-010b4f0ef97e", + "image_id": 204668, + "image_name": "12747.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1255.215, + 802.193, + 1038.311, + 554.943 + ], + "priority": 7, + "parents": [ + 107631 + ], + "children": [], + "area": 1006924.6864949999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 107632, + "strid": "1412bb5a-ac2b-489c-8881-ffcc377c009e", + "image_id": 204668, + "image_name": "12747.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 63.373, + 2084.533, + 244.39300000000003, + 44.27599999999984 + ], + "priority": 8, + "parents": [ + 107641 + ], + "children": [ + 107639, + 107638, + 107635, + 107634 + ], + "area": 132103.109809, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 107638, + "strid": "2f2c2356-8517-427b-b30c-3c21fb10bac3", + "image_id": 204668, + "image_name": "12747.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 50.758, + 1428.807, + 1064.605, + 571.002 + ], + "priority": 9, + "parents": [ + 107632 + ], + "children": [], + "area": 72523.385706, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 107639, + "strid": "96dc8d54-3303-4e5e-8825-a4959fdfc77a", + "image_id": 204668, + "image_name": "12747.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 957.326, + 1429.697, + 1358.7619999999997, + 1502.28 + ], + "priority": 10, + "parents": [ + 107632 + ], + "children": [], + "area": 1368686.110222, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 107634, + "strid": "4a7c2b30-790b-4a0b-907e-949e7ee3d307", + "image_id": 204668, + "image_name": "12747.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 61.427, + 2166.615, + 825.888, + 205.57900000000018 + ], + "priority": 11, + "parents": [ + 107632 + ], + "children": [], + "area": 133088.659605, + "iscrowd": 0, + "segmentation": [], + "text": "ELIXIR AAI (authentication and authorisation\ninfrastructure) is the ELIXIR Compute platform service\nportfolio for authenticating researchers and assisting\nthe relying services in deciding what they are permitted\nto do in the service." + }, + { + "id": 107635, + "strid": "1d30eeb0-aeae-4009-88f2-94635576a60f", + "image_id": 204668, + "image_name": "12747.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 58.665, + 2493.566, + 817.886, + 328.6410000000001 + ], + "priority": 12, + "parents": [ + 107632 + ], + "children": [], + "area": 146285.04939, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 92568, + "strid": "9139a32c-de84-409d-97e7-ebff6a49a325", + "image_id": 204087, + "image_name": "12143.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 2243.52, + 86.63, + 266.1199999999999, + 206.98000000000002 + ], + "priority": -1, + "parents": [], + "children": [ + 92550, + 92551, + 92556, + 92553, + 92552, + 92555, + 92549, + 92554 + ], + "area": 194356.1376, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 92549, + "strid": "934f2227-2e6e-4997-ba30-49d2ccd89f7f", + "image_id": 204087, + "image_name": "12143.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 56.451, + 77.193, + 2043.103, + 120.09000000000002 + ], + "priority": 1, + "parents": [ + 92568 + ], + "children": [], + "area": 4357.622043, + "iscrowd": 0, + "segmentation": [], + "text": "Gene Set Variation Analysis in cBioPortal" + }, + { + "id": 92550, + "strid": "8ef3d2ba-38d1-4bb7-b85f-6847e8d86ed3", + "image_id": 204087, + "image_name": "12143.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 59.812, + 237.168, + 1557.099, + 380.966 + ], + "priority": 2, + "parents": [ + 92568 + ], + "children": [], + "area": 14185.492416, + "iscrowd": 0, + "segmentation": [], + "text": "List of Authors & Presenter: Pieter Lukasse’, Fedde Schaeffer’, Oleguer Plantalech Casals’,\nSander Tan’, Dionne Zaal’, Ersin Ciftci?, Angelica Ochoa*, Adam Abeshouse®*, Hongxin Zhang’,\nYichao Sun’, Robert Sheridan’, JianJiong Gao*, Benjamin Gross*, Sjoerd van Hagen’,\n\nKees van Bochove’\n\n \n\n1 The Hyve, Arthur van Schendelstraat 650, 3511 MJ Utrecht, The Netherlands. Email: office@thehyve.nl\n1 The Hyve, Cambridge Innovation Center, 1 Broadway, 14th Floor, Cambridge, MA 02142, USA\n\n? Dana Farber Cancer Institute\n\n* Memorial Sloan Kettering Cancer Center" + }, + { + "id": 92551, + "strid": "4f312982-cae9-4d1c-857e-2bfbf6b981ab", + "image_id": 204087, + "image_name": "12143.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 91.5, + 674.112, + 176.171, + 36.138000000000034 + ], + "priority": 3, + "parents": [ + 92568 + ], + "children": [ + 92557 + ], + "area": 61681.248, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 92557, + "strid": "c4c5b8a4-7b08-466b-9b9e-026880a0fbbb", + "image_id": 204087, + "image_name": "12143.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 88.906, + 772.509, + 1550.122, + 747.652 + ], + "priority": 4, + "parents": [ + 92551 + ], + "children": [], + "area": 68680.685154, + "iscrowd": 0, + "segmentation": [], + "text": "cBioPortal is an open source application for integrative analysis and visualization of\nlarge scale cancer genomics datasets [1,2], originally developed by Memorial Sloan\nKettering Cancer Center (New York) and, since its open source release in 2015, by\na larger community including The Hyve (The Netherlands) [3].\n\nHere we present the recent features implemented for supporting Gene Set\nVariation Analysis (GSVA) in cBioPortal. We show how GSVA data is displayed in\nthe cBioPortal Oncoprint visualization, with support for hierarchical clustering, and\nhow it can be used in a variety of other plots and analyses.\n\nThis functionality is new in cBioPortal and could be useful to any of the users of this\npopular open source cancer genomics platform. GSVA support enables a new\ndimension of exploratory analysis in cBioPortal, allowing researchers to search and\nfind patterns at the level of molecular processes (i.e. multiple genes that are known\nto work in concert), instead of exploring the data at the level of individual genes." + }, + { + "id": 92553, + "strid": "16b8a278-8102-42d9-84b2-62aff2406c17", + "image_id": 204087, + "image_name": "12143.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 90.492, + 1621.789, + 428.3469999999999, + 37.97199999999998 + ], + "priority": 5, + "parents": [ + 92568 + ], + "children": [ + 92558, + 92559 + ], + "area": 146758.930188, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction to GSVA" + }, + { + "id": 92558, + "strid": "05cf7b2f-c4aa-4c7e-a5e0-e28dd80fe40a", + "image_id": 204087, + "image_name": "12143.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 89.318, + 1719.578, + 1550.129, + 448.80499999999984 + ], + "priority": 6, + "parents": [ + 92553 + ], + "children": [], + "area": 153589.267804, + "iscrowd": 0, + "segmentation": [], + "text": "Methods for analysing expression data at the level of gene sets (sometimes also\ncalled signatures) instead of single genes, have been presented in different forms.\nOne such method is the Gene Set Enrichment Analysis (GSEA)[4] which provides a\nsupervised method for finding enriched gene sets between two predefined sample\nsets. Among the unsupervised methods are Single Sample GSEA (ssGSEA)[5] and\nGene Set Variation Analysis (GSVA)[6], where each sample and gene set\ncombination gets a score representing the degree to which the genes in the gene\nset are coordinately up- or down-regulated within that sample. Figure 1 below\nsummarizes this concept." + }, + { + "id": 92559, + "strid": "885c86a9-3714-4ae2-8399-c799abfcc8dc", + "image_id": 204087, + "image_name": "12143.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 60.91, + 2254.098, + 1673.385, + 860.6300000000001 + ], + "priority": 7, + "parents": [ + 92553 + ], + "children": [ + 92560 + ], + "area": 137297.10918, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 92560, + "strid": "fd302804-e253-419e-9619-f4aa9d58bdeb", + "image_id": 204087, + "image_name": "12143.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 203.41, + 3197.287, + 1365.061, + 179.26200000000017 + ], + "priority": 8, + "parents": [ + 92559 + ], + "children": [], + "area": 650360.1486699999, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1: simplified illustration of how GSVA works, using data from Glioblastoma Multiforme (TCGA, Provisional),\nhighlighting each gene set / sample combination (top row) where the genes in the given gene set are coordinately up- or\ndown-regulated. The dotted line shows a group of genes that are part of the \"CDK Regulation of DNA Replication\" gene set\n(only 5 of the 18 genes are shown here). Green blocks are the samples where the genes in the \"CDK Regulation of DNA\nReplication\" gene set show coordinated down regulation, while magenta blocks show the samples where the genes show\ncoordinated up regulation." + }, + { + "id": 92554, + "strid": "372f4498-9dab-47ef-b637-e022e862cc18", + "image_id": 204087, + "image_name": "12143.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 88.717, + 3455.13, + 226.714, + 46.12300000000005 + ], + "priority": 9, + "parents": [ + 92568 + ], + "children": [ + 92561 + ], + "area": 306528.76821, + "iscrowd": 0, + "segmentation": [], + "text": "Availability" + }, + { + "id": 92561, + "strid": "45c9d0a0-d1b7-4c93-b052-f05c80de27a9", + "image_id": 204087, + "image_name": "12143.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 88.184, + 3553.831, + 1553.342, + 249.95699999999988 + ], + "priority": 10, + "parents": [ + 92554 + ], + "children": [], + "area": 313391.032904, + "iscrowd": 0, + "segmentation": [], + "text": "The features are available on The Hyve's cBioPortal server for a number of TCGA\n\nstudies: https://cbioportal.thehyve.net/cbioportal. Code (GNU AGPL v3) can be\nfound on GitHub: https://github.com/thehyve/cbioportal/tree/gsva_cbio. Processed\n\nGSVA data for TCGA studies can be found on GitHub (git LFS):\n\nhttps://github.com/thehyve/datahub/tree/gsva_results." + }, + { + "id": 92552, + "strid": "09bfb5b1-2888-4cc8-ac0d-4bae273debe9", + "image_id": 204087, + "image_name": "12143.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1806.905, + 1010.277, + 261.35900000000015, + 37.95700000000011 + ], + "priority": 11, + "parents": [ + 92568 + ], + "children": [ + 92565, + 92566 + ], + "area": 1825474.562685, + "iscrowd": 0, + "segmentation": [], + "text": "New features" + }, + { + "id": 92565, + "strid": "f74761ab-259a-4933-ba5c-b67923fc13e2", + "image_id": 204087, + "image_name": "12143.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1804.66, + 1108.138, + 1710.7189999999998, + 91.11799999999994 + ], + "priority": 12, + "parents": [ + 92552 + ], + "children": [], + "area": 1999812.32308, + "iscrowd": 0, + "segmentation": [], + "text": "To support GSVA in cBioPortal, new features were developed, highlighted in Figure 2\nbelow." + }, + { + "id": 92566, + "strid": "63dda858-7c32-4792-8718-e10d1da0f4ce", + "image_id": 204087, + "image_name": "12143.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1825.269, + 1214.483, + 1721.2550000000003, + 2047.322 + ], + "priority": 13, + "parents": [ + 92552 + ], + "children": [ + 92564 + ], + "area": 2216758.1709269998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 92564, + "strid": "43ca2968-5b06-4314-affd-91db0f449b0e", + "image_id": 204087, + "image_name": "12143.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1969.659, + 3329.728, + 1346.187, + 89.25599999999986 + ], + "priority": 14, + "parents": [ + 92566 + ], + "children": [], + "area": 6558428.722752, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2: some of the new features implemented for supporting GSVA in cBioPortal: new query options in the query page\n(Figure 2a), support for GSVA data in Oncoprint (Figure 2b), support for heatmap visualization and heatmap clustering in\nOncoprint (Figure 2c), support for GSVA in Plots tab (Figure 2d), support for GSVA in Co-expression tab (Figure 2e)." + }, + { + "id": 92556, + "strid": "4efab191-8647-4358-9717-d490bd810f2f", + "image_id": 204087, + "image_name": "12143.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1803.071, + 3465.875, + 655.6639999999998, + 46.108999999999924 + ], + "priority": 15, + "parents": [ + 92568 + ], + "children": [ + 92563, + 92567 + ], + "area": 6249218.702125, + "iscrowd": 0, + "segmentation": [], + "text": "About the cBioPortal community" + }, + { + "id": 92567, + "strid": "18860677-8f48-4f15-99db-be713e3c26cb", + "image_id": 204087, + "image_name": "12143.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1804.73, + 3566.457, + 1710.0750000000003, + 396.5540000000001 + ], + "priority": 16, + "parents": [ + 92556 + ], + "children": [], + "area": 6436491.94161, + "iscrowd": 0, + "segmentation": [], + "text": "Our community consists of a group of software engineers, bioinformaticians and cancer\nbiologists building software solutions for precision medicine for cancer patients. Our overall\ngoal is to build infrastructure to support clinical decisions for personalized cancer treatment\nby utilizing “big data” of cancer genomics and patient clinical profiles. Our multi-institutional\nteam currently has many active members, primarily from Memorial Sloan Kettering Cancer\nCenter in New York, the Dana-Farber Cancer Institute in Boston, Princess Margaret Cancer\nCentre in Toronto, Children's Hospital of Philadelphia, and The Hyve, a bioinformatics\ncompany from the Netherlands." + }, + { + "id": 92563, + "strid": "c7d0fd80-24db-48fe-90c7-8b2f235f56d6", + "image_id": 204087, + "image_name": "12143.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1905.822, + 3979.931, + 1600.55, + 658.6240000000003 + ], + "priority": 17, + "parents": [ + 92556 + ], + "children": [], + "area": 7585040.058282, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 92555, + "strid": "a07387a1-5b79-414d-97ab-0a4fb4d291d2", + "image_id": 204087, + "image_name": "12143.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 90.443, + 3873.687, + 229.026, + 38.552000000000135 + ], + "priority": 18, + "parents": [ + 92568 + ], + "children": [ + 92562 + ], + "area": 350347.873341, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 92562, + "strid": "2c16453b-09e9-403e-9bf4-3b234753ef67", + "image_id": 204087, + "image_name": "12143.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 88.996, + 3963.467, + 1573.814, + 659.1190000000001 + ], + "priority": 19, + "parents": [ + 92555 + ], + "children": [], + "area": 352732.709132, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 29305, + "strid": "6dc47ca2-3a0f-4ee7-b65f-801bd22b0497", + "image_id": 201657, + "image_name": "117473.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 329.29, + 83.89, + 231.09999999999997, + 249.34000000000003 + ], + "priority": -1, + "parents": [], + "children": [ + 29283, + 29284, + 29302, + 29299, + 29287, + 29285, + 29298, + 29286, + 29301 + ], + "area": 27624.1381, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 29283, + "strid": "0a663590-1e7e-4b36-b250-3a8c25806bb4", + "image_id": 201657, + "image_name": "117473.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 645.515, + 65.518, + 3504.912, + 246.417 + ], + "priority": 1, + "parents": [ + 29305 + ], + "children": [], + "area": 42292.85177, + "iscrowd": 0, + "segmentation": [], + "text": "ia Homogeneityand Resting State Functional Gennectivity:\nAssociations with Eafly Life Stress >" + }, + { + "id": 29284, + "strid": "f95b88ee-1914-4f00-9a25-51a0eef04157", + "image_id": 201657, + "image_name": "117473.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 863.63, + 378.612, + 3060.674, + 300.9030000000001 + ], + "priority": 2, + "parents": [ + 29305 + ], + "children": [], + "area": 326980.68156, + "iscrowd": 0, + "segmentation": [], + "text": "Noah S. Philip, M.D..09)" + }, + { + "id": 188721, + "strid": "3a5b7662-bbf3-448f-b091-fe9441821391", + "image_id": 207863, + "image_name": "8966.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 49.128, + 1851.503, + 911.011, + 357.5640000000001 + ], + "priority": 7, + "parents": [ + 188716 + ], + "children": [], + "area": 90960.639384, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 188728, + "strid": "7ed4070d-1e6a-4ed0-98f3-b3d0a16fc2b7", + "image_id": 207863, + "image_name": "8966.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 68.381, + 2255.926, + 820.074, + 395.5 + ], + "priority": 8, + "parents": [ + 188716 + ], + "children": [], + "area": 154262.475806, + "iscrowd": 0, + "segmentation": [], + "text": "Imaging\n\nAcquisition:\n\nCOS: 3T GE at the NIH NMR Research Facility.\nResting state — Five-minute scan, eyes open,\ncentral fixation.\n\nAOS: 3T Siemens at Washington University.\nResting state — 13.7 minutes, eyes closed." + }, + { + "id": 188729, + "strid": "da797087-50c8-405d-8166-2db30bead936", + "image_id": 207863, + "image_name": "8966.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 67.584, + 2710.093, + 792.375, + 420.01900000000023 + ], + "priority": 9, + "parents": [ + 188716 + ], + "children": [], + "area": 183158.925312, + "iscrowd": 0, + "segmentation": [], + "text": "Preprocessing/Analysis:\n\nAFNI ANATICOR approach. Cardiac and\nrespiratory cycles removed for COS (not\ncollected in AOS data). Cleaned, smoothed\nresidual time series spatially normalized to\nTalairach and Tournoux anatomic template.\nData quality of the two data sets was\ncomparable." + }, + { + "id": 188738, + "strid": "01c64786-9dbe-4875-abd4-d66bf13e5a62", + "image_id": 207863, + "image_name": "8966.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 65.168, + 3190.613, + 859.003, + 579.2220000000002 + ], + "priority": 10, + "parents": [ + 188716 + ], + "children": [], + "area": 207925.867984, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 188725, + "strid": "db8d1f19-ddcc-4035-aea8-0c46e993e473", + "image_id": 207863, + "image_name": "8966.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 700.107, + 3168.903, + 189.659, + 224.88099999999986 + ], + "priority": 11, + "parents": [ + 188716 + ], + "children": [], + "area": 2218571.1726209996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 188730, + "strid": "b52bfb37-83ea-4b4c-94c8-fe6906f462ed", + "image_id": 207863, + "image_name": "8966.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 67.584, + 3833.122, + 825.143, + 150.4319999999998 + ], + "priority": 12, + "parents": [ + 188716 + ], + "children": [], + "area": 259057.717248, + "iscrowd": 0, + "segmentation": [], + "text": "Clustering: K-means clustering of ROls into 2\nclusters, determined by Silhouette values and\nelbow plots." + }, + { + "id": 188731, + "strid": "b072eb4d-9440-4bc3-8ebd-753481e868a6", + "image_id": 207863, + "image_name": "8966.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 101.841, + 4040.152, + 768.544, + 98.30199999999968 + ], + "priority": 13, + "parents": [ + 188716 + ], + "children": [], + "area": 411453.119832, + "iscrowd": 0, + "segmentation": [], + "text": "No authors have conflicts of interest in\nrelation to this work." + }, + { + "id": 188714, + "strid": "877f1733-2e4d-40e7-8d66-a2ad62106306", + "image_id": 207863, + "image_name": "8966.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1044.231, + 653.372, + 305.317, + 79.50999999999999 + ], + "priority": 14, + "parents": [ + 188740 + ], + "children": [ + 188723, + 188722, + 188737, + 188735, + 188719, + 188734 + ], + "area": 682271.296932, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 188737, + "strid": "e0f51281-bcdb-4e1c-b17e-538a16f0f4ab", + "image_id": 207863, + "image_name": "8966.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1116.42, + 772.687, + 1474.2399999999998, + 168.08399999999995 + ], + "priority": 15, + "parents": [ + 188714 + ], + "children": [], + "area": 862643.2205400001, + "iscrowd": 0, + "segmentation": [], + "text": "We identified regions of decreased connectivity in COS and AOS patients\ncompared to their respective controls. Spatial coverage was greater in COS\n(181.0 cm? > 69.6 cm3)." + }, + { + "id": 188722, + "strid": "65591cbf-5299-483d-b9d6-c58453534f19", + "image_id": 207863, + "image_name": "8966.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1062.574, + 947.318, + 1425.194, + 755.4559999999999 + ], + "priority": 16, + "parents": [ + 188714 + ], + "children": [], + "area": 1006595.476532, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 188735, + "strid": "8117430a-7834-490f-8168-e2e8c1754f08", + "image_id": 207863, + "image_name": "8966.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1123.838, + 1750.691, + 1367.2480000000003, + 225.17000000000007 + ], + "priority": 17, + "parents": [ + 188714 + ], + "children": [], + "area": 1967493.072058, + "iscrowd": 0, + "segmentation": [], + "text": "We used the regions with reduced connectedness in patients (above)\nas seeds to find regions driving connectedness differences. These\n“seed” plus “non-seed” ROls clustered into two networks: social-\n\ncognitive (red) and motor-sensory (green)." + }, + { + "id": 188723, + "strid": "027ba805-d4d9-4884-9069-22bf197c2eff", + "image_id": 207863, + "image_name": "8966.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1109.365, + 1994.879, + 1299.0309999999997, + 741.998 + ], + "priority": 18, + "parents": [ + 188714 + ], + "children": [ + 188726, + 188727 + ], + "area": 2213048.9418349997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 188726, + "strid": "2ea01b17-3988-41f7-be68-e0fe73eeee75", + "image_id": 207863, + "image_name": "8966.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1179.121, + 2752.645, + 506.5329999999999, + 47.034999999999854 + ], + "priority": 19, + "parents": [ + 188723 + ], + "children": [], + "area": 3245701.525045, + "iscrowd": 0, + "segmentation": [], + "text": "Cluster 1: social-cognitive" + }, + { + "id": 188727, + "strid": "02d361d4-8018-4bc1-b173-659d0547ab79", + "image_id": 207863, + "image_name": "8966.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1841.233, + 2751.439, + 492.0609999999999, + 48.240999999999985 + ], + "priority": 20, + "parents": [ + 188723 + ], + "children": [], + "area": 5066040.284286999, + "iscrowd": 0, + "segmentation": [], + "text": "Cluster 2: motor-sensory" + }, + { + "id": 188734, + "strid": "28c160c2-e372-40f6-a379-c5a55191a3b5", + "image_id": 207863, + "image_name": "8966.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1141.486, + 2843.626, + 1275.6609999999998, + 46.0949999999998 + ], + "priority": 21, + "parents": [ + 188714 + ], + "children": [], + "area": 3245959.2682360006, + "iscrowd": 0, + "segmentation": [], + "text": "We found a total of 23 ROIs in COS and 18 in AOS, in 2 networks." + }, + { + "id": 188719, + "strid": "6c0fa99d-2495-4531-bedd-f473a25f6c10", + "image_id": 207863, + "image_name": "8966.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1113.83, + 2905.854, + 1437.551, + 1250.1439999999998 + ], + "priority": 22, + "parents": [ + 188714 + ], + "children": [], + "area": 3236627.3608199996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 188715, + "strid": "fafb079a-a814-408a-9740-299fce98a2fc", + "image_id": 207863, + "image_name": "8966.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2760.49, + 650.665, + 468.5050000000001, + 81.47900000000004 + ], + "priority": 23, + "parents": [ + 188740 + ], + "children": [ + 188739, + 188733, + 188732, + 188736, + 188720, + 188724 + ], + "area": 1796154.2258499998, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion" + }, + { + "id": 188739, + "strid": "d6cb320b-7b32-4bba-87b9-5c2d49d245b1", + "image_id": 207863, + "image_name": "8966.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2701.184, + 781.161, + 1438.13, + 688.4330000000001 + ], + "priority": 24, + "parents": [ + 188715 + ], + "children": [], + "area": 2110059.594624, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 188736, + "strid": "6cfb2874-868e-4dd0-bbe3-52f58a421ae3", + "image_id": 207863, + "image_name": "8966.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2720.52, + 1573.016, + 1374.348, + 160.32400000000007 + ], + "priority": 25, + "parents": [ + 188715 + ], + "children": [], + "area": 4279421.4883200005, + "iscrowd": 0, + "segmentation": [], + "text": "Region-by-region correlations highlight decreased across-network\ncorrelations in COS and AOS. The reductions were more extreme, and\neven negative, for COS." + }, + { + "id": 188724, + "strid": "df79cbc4-f00c-4dd3-9c30-9105c943c47f", + "image_id": 207863, + "image_name": "8966.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2529.631, + 1736.393, + 1651.0350000000003, + 1115.614 + ], + "priority": 26, + "parents": [ + 188715 + ], + "children": [], + "area": 4392433.560982999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 188733, + "strid": "5ec5079f-07b5-424a-8848-8ccfb0bf58ed", + "image_id": 207863, + "image_name": "8966.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2469.455, + 2872.259, + 1705.9079999999994, + 84.82400000000007 + ], + "priority": 27, + "parents": [ + 188715 + ], + "children": [], + "area": 7092914.348844999, + "iscrowd": 0, + "segmentation": [], + "text": "Correlation matrices show the r value for each ROI-ROI pair. Row/column order of ROIs in the matrices is\nidentical to those provided in the tables (below), from bottom to top row and leftmost to rightmost column." + }, + { + "id": 188720, + "strid": "d9a6b20d-1a4a-4e0e-84e8-b404a030839f", + "image_id": 207863, + "image_name": "8966.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2725.414, + 3006.216, + 1403.417, + 1031.743 + ], + "priority": 28, + "parents": [ + 188715 + ], + "children": [], + "area": 8193183.173424, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 188732, + "strid": "15ef3c64-f4e5-4fc4-86df-07f3f1572cb4", + "image_id": 207863, + "image_name": "8966.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2725.676, + 4049.178, + 1441.7130000000002, + 118.6319999999996 + ], + "priority": 29, + "parents": [ + 188715 + ], + "children": [], + "area": 11036747.294327999, + "iscrowd": 0, + "segmentation": [], + "text": "x,y,z = Talairach coordinates of the peak difference (for seeds) or center of mass (for non-seeds).\nSeeds, in bold, corrected at p<0.0005. Large-scale network membership denoted by color (red/green).\nA1/A2: primary/secondary auditory cortex." + }, + { + "id": 75019, + "strid": "fe76ff83-f6c6-41ed-bbba-11275a75b980", + "image_id": 203426, + "image_name": "120207.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 72.85, + 57.57, + 243.94000000000003, + 258.72 + ], + "priority": -1, + "parents": [], + "children": [ + 75003, + 75012, + 75005, + 75010, + 75008, + 75018, + 75004, + 75017 + ], + "area": 4193.974499999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 75003, + "strid": "71c59d2a-7c4b-413c-bc65-cb412af016a1", + "image_id": 203426, + "image_name": "120207.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 354.219, + 137.559, + 3055.695, + 348.81000000000006 + ], + "priority": 1, + "parents": [ + 75019 + ], + "children": [], + "area": 48726.011420999996, + "iscrowd": 0, + "segmentation": [], + "text": "Reduced globus pallidus volumes\nfollowing focal cerebellar lesions in humans" + }, + { + "id": 75004, + "strid": "54a60447-a7a6-4814-ae01-b7b99e77d8d0", + "image_id": 203426, + "image_name": "120207.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 232.41, + 541.439, + 3336.402, + 266.49699999999996 + ], + "priority": 2, + "parents": [ + 75019 + ], + "children": [], + "area": 125835.83798999999, + "iscrowd": 0, + "segmentation": [], + "text": "Torgeir Moberget?, Andreea C. Bostan?, Tryggve Lundar?, Bent Due-Ténnesen?, Aasta Heldal*, Stein Andersson’, Tor Endestad & Lars T. Westlye?°\n\n1Department of Psychology, University of Oslo, Oslo, Norway, 2Center for the Neural Basis of Cognition, Systems Neuroscience Institute and Department of Neurobiology,\nUniversity.of Pittsburgh School of Medicine, Pittsburgh, PA, USA, *Deépartment of Neurosurgery, Oslo University Hospital, OslojNorway, “Department of Psychosomatic Medicine,\nOslo University Hospital, Oslo, Norway, °KG Jebsen Centre.for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway." + }, + { + "id": 75005, + "strid": "ac1cb131-2cc4-47fc-8596-4e8edf100733", + "image_id": 203426, + "image_name": "120207.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 122.989, + 953.541, + 439.96799999999996, + 83.47500000000002 + ], + "priority": 3, + "parents": [ + 75019 + ], + "children": [ + 75006 + ], + "area": 117275.05404900001, + "iscrowd": 0, + "segmentation": [], + "text": "Background:" + }, + { + "id": 75006, + "strid": "3cc8198e-ef47-4302-bb43-e76c6c70925f", + "image_id": 203426, + "image_name": "120207.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 127.316, + 1082.013, + 1297.383, + 1200.8720000000003 + ], + "priority": 4, + "parents": [ + 75005 + ], + "children": [], + "area": 137757.567108, + "iscrowd": 0, + "segmentation": [], + "text": "Recent tract-tracing studies in rodents! “and non-human\nprimates** demonstrate reciprocal connections between the\ncerebellum and the basal ganglia, suggesting that these\nstructures, previously viewed as relatively independent, may\nbe linked to form an integrated functional network’.\n\nFurther, evidence from neurophysiological animal studies\ninvestigating basal ganglia(effects of either stimulating>® or\nlesioning’? the cerebellum strongly support the functional\nrelevance of these connections.\n\nAlthough resultsfrom functional imaging studies of healthy\nparticipants ands studies of patients with basal ganglia\npathology are consistent with this account’, direct evidence\nfrom humans is still relatively scarce. In particular, therevis a\nlackmof/ human studies examining effects of cerebellar\npathology on basal ganglia structure and function.\n\nThe aim of the present study was to investigate basal ganglia\nvolumes (as well as the intermediate thalamus and\nbrainstem) in patients with focal cerebellaresions using\ncomprehensive MRI-based morphometric analyses." + }, + { + "id": 75008, + "strid": "67c8a9e6-de73-448f-a127-a3c74ed7c8d6", + "image_id": 203426, + "image_name": "120207.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 135.842, + 2457.587, + 441.312, + 81.94399999999996 + ], + "priority": 5, + "parents": [ + 75019 + ], + "children": [ + 75007, + 75009 + ], + "area": 333843.533254, + "iscrowd": 0, + "segmentation": [], + "text": "Participants:" + }, + { + "id": 75007, + "strid": "9ed3bc66-49a9-4469-8908-7386457ed554", + "image_id": 203426, + "image_name": "120207.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 124.395, + 2560.201, + 1285.664, + 514.672 + ], + "priority": 6, + "parents": [ + 75008 + ], + "children": [], + "area": 318476.203395, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 75009, + "strid": "22402c84-35df-4731-b041-b344deedbef5", + "image_id": 203426, + "image_name": "120207.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 117.018, + 3149.74, + 1287.355, + 388.616 + ], + "priority": 7, + "parents": [ + 75008 + ], + "children": [], + "area": 368576.27531999996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 75010, + "strid": "70f5f024-a5ba-4db9-88ad-ffc5c998e6ea", + "image_id": 203426, + "image_name": "120207.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 129.161, + 3680.772, + 783.557, + 75.92599999999993 + ], + "priority": 8, + "parents": [ + 75019 + ], + "children": [ + 75011 + ], + "area": 475412.192292, + "iscrowd": 0, + "segmentation": [], + "text": "Morphometrvin brief:" + }, + { + "id": 75011, + "strid": "f8e97c7e-abda-4457-adc0-2dd86325e0dc", + "image_id": 203426, + "image_name": "120207.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 123.701, + 3801.044, + 1303.369, + 378.8860000000004 + ], + "priority": 9, + "parents": [ + 75010 + ], + "children": [], + "area": 470192.94384399994, + "iscrowd": 0, + "segmentation": [], + "text": "T1-weighted MRI-scans were segmented using FreeSurfer 5.3\n(http://surfersamr.mgh.harvard.edu/) and FIRST 5.0 (FSL\ntoolbox, FMRIB, Oxford, UK).\n\nSegmentations of the nucleus accumbens were not included\n\nin the volumetric analyses, as a previous study found (these to\nbeunreliable®." + }, + { + "id": 75018, + "strid": "38a126fc-e921-4d09-924e-04b13f55f1d9", + "image_id": 203426, + "image_name": "120207.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1603.036, + 979.309, + 2562.977, + 3186.562 + ], + "priority": 10, + "parents": [ + 75019 + ], + "children": [], + "area": 1569867.582124, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 75012, + "strid": "8d5bf111-d36c-4760-9c97-69c87a219e05", + "image_id": 203426, + "image_name": "120207.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 137.608, + 4346.605, + 1549.021, + 63.01100000000042 + ], + "priority": 11, + "parents": [ + 75019 + ], + "children": [ + 75015, + 75014, + 75013 + ], + "area": 598127.62084, + "iscrowd": 0, + "segmentation": [], + "text": "Details regarding data collection and morphometric analysis:" + }, + { + "id": 75013, + "strid": "e24c7358-3969-41c5-a38b-abd92312b5e2", + "image_id": 203426, + "image_name": "120207.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 140.311, + 4436.038, + 2046.8930000000003, + 174.40499999999975 + ], + "priority": 12, + "parents": [ + 75012 + ], + "children": [], + "area": 622424.927818, + "iscrowd": 0, + "segmentation": [], + "text": "MRI-acquisition: Imaging was performed with a.Philips Achieva 3 Tesla whole body MR unit equipped with an 8-chamnel Philips\nSENSE head coil (Philips Medical Systems, Best, the Netherlands). The protocol included a T1-weighted MPRAGE and pUlse sequence\nused for lesion reconstruction and morphometry and a fluid-attenuated inversion recovery (FLAIR) sequence to aid the\nneuroradiologic examination and lesion féconstruction." + }, + { + "id": 75014, + "strid": "d619dc6d-33ed-48b8-9ec6-dd756d2561e1", + "image_id": 203426, + "image_name": "120207.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 140.264, + 4627.153, + 2046.442, + 465.8819999999996 + ], + "priority": 13, + "parents": [ + 75012 + ], + "children": [], + "area": 649022.9883920001, + "iscrowd": 0, + "segmentation": [], + "text": "Volumetric segmentation: Image pfocessing and segmentation were performed with two automated procedures; FreeSurfer 5.3\n(http://surfer.nmr.mgh.harvard.edii/)*and FIRST 5.0 (FSL toolbox, FMRIB, Oxford, UK). FreeSurfer segmentation yields volumetric\nestimates for total cerebralfand cerebellar grey and white matter, subcortical structures, corpus callosum, and ventricular regions\nbased on probabilistic topological relationships and signal intensities. FIRST employs an iterativeprocedure to derive a surface mesh\nsegmentation of structuresderived from a set of 317 basis functions and transforms these meshrepresentations to volumes’.\n\nThe use of two complementary segmentation algorithms was motivated by results from.a ‘recent study showing poor agreement\nbetween segméntations using FreeSurfer and FIRST, possibly reflecting differences across Manual expert raters, as the algorithms\nwere informed by\"training datasets segmented by different sets of raters®. Requiring that results replicate across different\nsegmentation procedures, should render them more robust with respect to potential/biases inherent in any particular segmentation\nprocedure." + }, + { + "id": 75015, + "strid": "e2b0b3da-06f8-42e1-84d2-64fae0915eae", + "image_id": 203426, + "image_name": "120207.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 136.945, + 5112.442, + 2050.747, + 420.3109999999997 + ], + "priority": 14, + "parents": [ + 75012 + ], + "children": [], + "area": 700123.36969, + "iscrowd": 0, + "segmentation": [], + "text": "Statistical analysis: All statistical analyses of volumetric differences between\\cerebellar patients and healthy controls were carried\nout.using analyses of covariance (ANCOVAs) in IBM SPSS 21. Group (patients, controls) was included as a fixed factor, and age and\nestimated intracranial volume was used as covariates. Since we/Observed a significant group difference in IQ (10 points), we\nconducted a set of control analyses with full scale 1Q included’ as) aneadditional covariate. A final set of control analyses examined\npossible effects of concomitant hydrocephalus (very common in this patient group) by including ventricular volume as a covariate\n\nThe correspondence between volume estimates from the two segmentation procedures were examined using Pearson correlation\nanalyses and a final set of (repeated measures) ANCOVAs were performed on estimated volumes from both pipelines ‘with\nsegmentation procedure (two levels: FreeSurfer,“FIRST) and group (two levels: Patients, Controls) as fixed factors and agé and\nestimated intracranial volume as covariates." + }, + { + "id": 75017, + "strid": "3830c87c-71d2-4975-bc12-bc12e3867df4", + "image_id": 203426, + "image_name": "120207.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2359.36, + 4359.69, + 433.21799999999985, + 66.5640000000003 + ], + "priority": 15, + "parents": [ + 75019 + ], + "children": [ + 75016 + ], + "area": 10286078.1984, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions:" + }, + { + "id": 75016, + "strid": "65d8ebfa-3dc9-443b-8faa-d595ec38f601", + "image_id": 203426, + "image_name": "120207.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2361.515, + 4452.33, + 1813.3880000000004, + 522.8209999999999 + ], + "priority": 16, + "parents": [ + 75017 + ], + "children": [], + "area": 10514244.07995, + "iscrowd": 0, + "segmentation": [], + "text": "Across two automated segmentation pipelines we observed significantly reduced\nglobus pallidus volumes inpatients with focal cerebellar lesions.\n\nThe underlying mechanism(s) behind — or the functional significance of — these results\nremains unknown. Suggestions are very welcome!\n\nHowever, since the globus pallidus exerts an inhibitory effectt+*on cortical areas\nreceiving excitatory input from the deep cerebellar nuclei##, we¢speculate that the\nreduced pallidal volumes in cerebellar patients reflect compensatory adjustments\nwithin anintegrated cerebello-basal ganglia system." + }, + { + "id": 123070, + "strid": "1e6d6f5f-cbef-40df-9324-178e3955fbb3", + "image_id": 205293, + "image_name": "14596.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 20.52, + 47.08, + 81.5, + 358.58000000000004 + ], + "priority": -1, + "parents": [], + "children": [ + 123060, + 123061, + 123057, + 123055, + 123058, + 123056, + 123059 + ], + "area": 966.0816, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 123056, + "strid": "e0d0e510-c7ce-471f-b9f0-81bbfec2e2e1", + "image_id": 205293, + "image_name": "14596.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 122.453, + 147.53, + 2377.733, + 201.585 + ], + "priority": 1, + "parents": [ + 123070 + ], + "children": [], + "area": 18065.49109, + "iscrowd": 0, + "segmentation": [], + "text": "ASSOCIATION BETWEEN ANTIMICROBIAL CONSUMPTION\nAND AMR IN GONORRHOEA IN AUSTRALIAN STATES" + }, + { + "id": 123055, + "strid": "041f68a3-cfdb-4dd0-a101-72c44b6c30ec", + "image_id": 205293, + "image_name": "14596.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 138.677, + 487.315, + 2100.524, + 215.92000000000002 + ], + "priority": 2, + "parents": [ + 123070 + ], + "children": [], + "area": 67579.38225499999, + "iscrowd": 0, + "segmentation": [], + "text": "(Ora C=T ahve)\n\nInstitute of Tropical Medicine, Department of Clinical Sciences, Antwerp, Belgium" + }, + { + "id": 123057, + "strid": "e78aca9e-c640-486b-abe2-8dd09c570e3a", + "image_id": 205293, + "image_name": "14596.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 123.492, + 819.522, + 565.515, + 64.78599999999994 + ], + "priority": 3, + "parents": [ + 123070 + ], + "children": [ + 123062 + ], + "area": 101204.410824, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 123062, + "strid": "4eca9d89-3fec-4901-b0d9-2f12fb3b1a7e", + "image_id": 205293, + "image_name": "14596.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 89.864, + 1009.13, + 1727.382, + 332.55100000000004 + ], + "priority": 4, + "parents": [ + 123057 + ], + "children": [], + "area": 90684.45832, + "iscrowd": 0, + "segmentation": [], + "text": "The prevelence of gonococcal antimicrobial resistance\n(AMR) to a range of antimicrobials in the rural part of\nthe Northern Territories Australia is so low that penicillin\nremains the first line treatment." + }, + { + "id": 123059, + "strid": "a36ba2b1-a3a1-4ebb-96ec-1f877abc6295", + "image_id": 205293, + "image_name": "14596.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 119.319, + 1426.757, + 153.349, + 62.98299999999995 + ], + "priority": 5, + "parents": [ + 123070 + ], + "children": [ + 123063 + ], + "area": 170239.218483, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 123063, + "strid": "d2687e99-17d4-43b5-a8f7-fccd52f4bf9a", + "image_id": 205293, + "image_name": "14596.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 68.937, + 1626.758, + 1741.495, + 398.60000000000014 + ], + "priority": 6, + "parents": [ + 123059 + ], + "children": [], + "area": 112143.816246, + "iscrowd": 0, + "segmentation": [], + "text": "We assessed if there was an association between the\nconsumption of antimicrobials in the general population\nand the prevalence of AMR in Neisseria gonorrhoeae at a\nstate level in Australia. This association has previously\nbeen found in country level analyses." + }, + { + "id": 123060, + "strid": "3ca9f2e4-578b-4ea5-9cea-5949c8cd6b39", + "image_id": 205293, + "image_name": "14596.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 123.212, + 2180.066, + 369.297, + 67.76999999999998 + ], + "priority": 7, + "parents": [ + 123070 + ], + "children": [ + 123064 + ], + "area": 268610.29199199995, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 123064, + "strid": "1b8a97fd-b059-4d5d-8e81-9c87f65f1f88", + "image_id": 205293, + "image_name": "14596.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 64.531, + 2417.237, + 1695.29, + 1963.6359999999995 + ], + "priority": 8, + "parents": [ + 123060 + ], + "children": [], + "area": 155986.72084700002, + "iscrowd": 0, + "segmentation": [], + "text": "Data for AMR was taken from the most recent\nAustralian Gonococcal Surveillance Programme Annual\nReport in 2017 (https://doi.org/10.33321/cdi.2019.43.13).\nThis provided AMR data by state for isolates from the\nyear 2017. Penicillin resistance was defined as a MIC\ngreater than 1mg/L or more or the presence of a\npenicillinase.\n\nAntimicrobial consumption data was obtained from the\nonly source we could find with state level antimicrobial\nconsumption data reorted for the general population.\nThis was the Australian Atlas of Healthcare Variation\n2018 (www.safetyandquality.gov.au/atlas/). This\nreported the number of RBS/PBS prescriptions\ndispensed for amoxicillin-clavulanate per 100,000\ninhabitants and calculated the defined daily doses\n(DDD) per 1000 inhabitants per day in the period 2016\nto 2017. Data was reported for amoxillicin-clavulanate\nand no other antimicrobials.\n\nSpearman’s correlation was used to test the association\nbetween AMR and antimicrobial consumption." + }, + { + "id": 123058, + "strid": "ccba6794-3233-4162-886f-408dce7cf33a", + "image_id": 205293, + "image_name": "14596.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1979.658, + 812.447, + 300.21900000000005, + 64.91200000000003 + ], + "priority": 9, + "parents": [ + 123070 + ], + "children": [ + 123067, + 123069, + 123065 + ], + "area": 1608367.203126, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 123065, + "strid": "58b5ef10-2bd2-4fb9-b1c7-52203152a20b", + "image_id": 205293, + "image_name": "14596.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1913.296, + 998.952, + 1755.8149999999998, + 936.3120000000001 + ], + "priority": 10, + "parents": [ + 123058 + ], + "children": [], + "area": 1911290.865792, + "iscrowd": 0, + "segmentation": [], + "text": "The prevalence of penicillin resistance varied between\n2.5% in the remote region of the Northern Territories and\n44.1% in Tasmania (median 22.6%, IQR 10.3-29.6%).\n\nThe consumption of amoxicillin-clavulanate varied\nbetween 2.64 (Northern Territories) and 5.03\n(Queensland; median 4.23 (IQR 3.63-4.77) DDD per 1000\ninhabitants per day.\n\nThere was a non-significant positive association between\nconsumption of amoxicillin-clavulanate and penicillin\nresistance. (rho=0.46; P=0.3; Fig 1)." + }, + { + "id": 123067, + "strid": "c81cbcf0-5625-4f22-af62-77891bcade98", + "image_id": 205293, + "image_name": "14596.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1917.447, + 1965.518, + 1685.5559999999998, + 581.0190000000002 + ], + "priority": 11, + "parents": [ + 123058 + ], + "children": [], + "area": 3768776.5925459997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 123069, + "strid": "78f655d4-2c66-44a3-868e-3b834e12dfc9", + "image_id": 205293, + "image_name": "14596.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1914.945, + 2761.003, + 1650.0910000000001, + 1200.038 + ], + "priority": 12, + "parents": [ + 123058 + ], + "children": [ + 123068 + ], + "area": 5287168.889835, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 123068, + "strid": "b9b05dcb-ee46-4a01-b9f7-2081738a3868", + "image_id": 205293, + "image_name": "14596.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1908.726, + 4031.715, + 1649.351, + 253.9949999999999 + ], + "priority": 13, + "parents": [ + 123069 + ], + "children": [], + "area": 7695439.24509, + "iscrowd": 0, + "segmentation": [], + "text": "Fig 1. Consumption of amoxicillin-clavulanate (defined\ndaily doses (DDD) per 1000 population per day versus\npenicillin resistance" + }, + { + "id": 123061, + "strid": "481d5f3f-ab33-4e17-b8c3-256d1820d3a6", + "image_id": 205293, + "image_name": "14596.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 122.502, + 4481.581, + 518.348, + 65.42299999999977 + ], + "priority": 14, + "parents": [ + 123070 + ], + "children": [ + 123066 + ], + "area": 549002.635662, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 123066, + "strid": "5da9ebf4-5b65-49ec-9e9f-d096a457c271", + "image_id": 205293, + "image_name": "14596.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 67.037, + 4645.232, + 3190.144, + 163.84299999999985 + ], + "priority": 15, + "parents": [ + 123061 + ], + "children": [], + "area": 311402.41758400004, + "iscrowd": 0, + "segmentation": [], + "text": "The lower consumption of antimicrobials in the general population in the remote region of the Northern\nTerritories Australia may play a role in the lower prevalence of AMR in N. gonorrhoeae in this population." + }, + { + "id": 143252, + "strid": "8a224ca7-a642-42b1-97ee-95190813ec63", + "image_id": 206067, + "image_name": "17312.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 98.34, + 79.86, + 162.01000000000002, + 171.52999999999997 + ], + "priority": -1, + "parents": [], + "children": [ + 143231, + 143230, + 143232, + 143229, + 143228, + 143227, + 143250 + ], + "area": 7853.432400000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143227, + "strid": "0160b5dd-19db-49c3-abe0-7d795f559d88", + "image_id": 206067, + "image_name": "17312.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 1677.786, + 156.111, + 3366.968, + 183.89999999999998 + ], + "priority": 1, + "parents": [ + 143252 + ], + "children": [], + "area": 261920.850246, + "iscrowd": 0, + "segmentation": [], + "text": "A Non-redundant, Reference Virus Database (RVDB) to Facilitate High-throughput\nSequencing (HTS) Bioinformatics Analysis for Detection of Known and Novel Viruses" + }, + { + "id": 143228, + "strid": "7dba4c3b-6f8e-495d-8718-956163df49f2", + "image_id": 206067, + "image_name": "17312.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1747.783, + 385.015, + 3229.7049999999995, + 122.29500000000002 + ], + "priority": 2, + "parents": [ + 143252 + ], + "children": [], + "area": 672922.6717449999, + "iscrowd": 0, + "segmentation": [], + "text": "Pei-Ju Chin and Arifa S. Khan\n\nOffice of Vaccines Research and Review, Division of Viral Products, Laboratory of Retroviruses, CBER, U.S. Food and Drug Administration, Silver Spring, MD 20993" + }, + { + "id": 143229, + "strid": "f9fcffda-1778-4631-b1a6-38517f5f4b9b", + "image_id": 206067, + "image_name": "17312.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 125.489, + 647.282, + 335.81499999999994, + 55.96900000000005 + ], + "priority": 3, + "parents": [ + 143252 + ], + "children": [ + 143233, + 143234 + ], + "area": 81226.770898, + "iscrowd": 0, + "segmentation": [], + "text": "Background:" + }, + { + "id": 143233, + "strid": "35c0479a-2a11-4570-b6a0-26ba8873b1f0", + "image_id": 206067, + "image_name": "17312.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 491.215, + 656.016, + 2113.149, + 44.86500000000001 + ], + "priority": 4, + "parents": [ + 143229 + ], + "children": [], + "area": 322244.89943999995, + "iscrowd": 0, + "segmentation": [], + "text": "Genomic and metagenomic analysis using high-throughput sequencing (HTS) has resulted in a great expansion of the" + }, + { + "id": 143234, + "strid": "b8097115-3ce6-47a0-b727-ec739018bab9", + "image_id": 206067, + "image_name": "17312.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 122.163, + 710.828, + 2491.267, + 460.2149999999999 + ], + "priority": 5, + "parents": [ + 143229 + ], + "children": [], + "area": 86836.880964, + "iscrowd": 0, + "segmentation": [], + "text": "virosphere. However, there are challenges for HTS bioinformatics for detecting distantly-related viruses due to limitations of the publicly-\navailable databases, which are not complete with all viral sequences, and virus detection can be obscured using the NCBI nr/nt collection, which\ncontains diverse viral sequences, due to the large amount of cellular sequences. This gap was recognized by our laboratory during HTS\ninvestigations of Sf9 insect cells, which are a new cell substrate used for several baculovirus-expressed vaccines and other products. Those\nstudies led to the discovery of a novel rhabdovirus in Sf9 cells, which had very limited sequence identity to any known virus (only 4% coverage\nin a 295-bp region with 66% nucleotide identity to Taastrup virus, a new member of the family Mononegavirales) [1]. Therefore, we initiated\nefforts to create a new, non-redundant, reference viral database (RVDB) that would include all virus, virus-related, and viral-like sequences,\nincluding endogenous viruses and retroelements, and have an overall reduced cellular sequence content. This effort was in consultation with\nthe Advanced Virus Detection Technologies Interest Group, which includes scientists from industry (vaccines and biotherapeutics), regulatory\nand other government agencies (including NCBI), technology service providers, and academia [2]." + }, + { + "id": 143230, + "strid": "e388496f-0399-40a1-9c1d-f02c00d2145e", + "image_id": 206067, + "image_name": "17312.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 124.888, + 1275.302, + 239.10600000000002, + 43.575000000000045 + ], + "priority": 6, + "parents": [ + 143252 + ], + "children": [ + 143242, + 143237, + 143244, + 143241, + 143235, + 143243, + 143238, + 143236 + ], + "area": 159269.916176, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 143235, + "strid": "ac8390e8-98b0-487b-8ef9-5da3eb27ca26", + "image_id": 206067, + "image_name": "17312.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 387.832, + 1286.212, + 2222.69, + 40.396999999999935 + ], + "priority": 7, + "parents": [ + 143230 + ], + "children": [], + "area": 498834.172384, + "iscrowd": 0, + "segmentation": [], + "text": "The overall strategy for developing RVDB included: a) development of a refined, final keyword screen for semantic selection of" + }, + { + "id": 143236, + "strid": "d678d5c0-5466-4c7a-80e1-afd55e1768ae", + "image_id": 206067, + "image_name": "17312.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 119.105, + 1337.421, + 2491.726, + 274.42599999999993 + ], + "priority": 8, + "parents": [ + 143230 + ], + "children": [], + "area": 159293.528205, + "iscrowd": 0, + "segmentation": [], + "text": "all virus, virus-related, and virus-like sequences from GenBank, regardless of their size;, b) verification of viral identity using various\nbioinformatics tools (BLAST and HMMER); c) clustering at 98% sequence identity using CD-HIT-EST to remove redundancy; and d) testing\nrobustness of RVDB for HTS analysis using our large, in-house next-gen datasets and comparing the run time and results to those obtained\nusing the NCBI databases (NCBI Viral RefSeq + genome neighbors and nr/nt). The overall strategy, with details of the different steps of\nselection and analysis, is shown in Fig. 1. Details of the generation and characterization of RVDBv10.2 is described by Goodacre et. al. [3]. The\ncharacterization of the latest RVDB v20.0 is shown in Fig. 2." + }, + { + "id": 143237, + "strid": "c7cad5c4-1e98-44f0-bf30-45dd8483d9e0", + "image_id": 206067, + "image_name": "17312.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 160.114, + 1754.584, + 1112.913, + 55.49700000000007 + ], + "priority": 9, + "parents": [ + 143230 + ], + "children": [], + "area": 280933.462576, + "iscrowd": 0, + "segmentation": [], + "text": "1, General Workflow for Development of RVDB" + }, + { + "id": 143241, + "strid": "fefce8a7-d698-4e7c-a184-482d7aba9dca", + "image_id": 206067, + "image_name": "17312.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 106.302, + 1876.249, + 1211.545, + 544.5620000000001 + ], + "priority": 10, + "parents": [ + 143230 + ], + "children": [], + "area": 199449.021198, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143242, + "strid": "f8834b30-93b0-4bfb-9535-a784c36531ef", + "image_id": 206067, + "image_name": "17312.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 110.523, + 2493.982, + 1205.917, + 733.1190000000001 + ], + "priority": 11, + "parents": [ + 143230 + ], + "children": [], + "area": 275642.372586, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143238, + "strid": "d08df023-ad7d-4215-907f-c9137925c44f", + "image_id": 206067, + "image_name": "17312.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1635.144, + 1757.289, + 750.7070000000001, + 43.50700000000006 + ], + "priority": 12, + "parents": [ + 143230 + ], + "children": [], + "area": 2873420.564616, + "iscrowd": 0, + "segmentation": [], + "text": "Division Characters in RVDB" + }, + { + "id": 143243, + "strid": "69169975-55ac-49ed-928d-b3e97adfbe43", + "image_id": 206067, + "image_name": "17312.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1424.737, + 1904.632, + 1184.475, + 1381.725 + ], + "priority": 13, + "parents": [ + 143230 + ], + "children": [], + "area": 2713599.6817840002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143244, + "strid": "cd3717f4-c91b-4eb3-8f03-7afc72a664ca", + "image_id": 206067, + "image_name": "17312.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1400.143, + 3395.881, + 1221.062, + 132.19900000000007 + ], + "priority": 14, + "parents": [ + 143230 + ], + "children": [], + "area": 4754719.010983, + "iscrowd": 0, + "segmentation": [], + "text": "Total number of entries in RVDBv20.0: 3,180,577 including the\nsequences of NCBI RefSeq Viral (n=9,350) and NCBI Genome\nNeighbors (n=216,849)" + }, + { + "id": 143231, + "strid": "51bf7eff-eff9-4425-b6c9-f483721e9424", + "image_id": 206067, + "image_name": "17312.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2849.264, + 649.615, + 210.6790000000001, + 44.65499999999997 + ], + "priority": 15, + "parents": [ + 143252 + ], + "children": [ + 143245 + ], + "area": 1850924.63336, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 143245, + "strid": "c6a95f95-d2d9-4463-b41b-133c86676d29", + "image_id": 206067, + "image_name": "17312.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2845.116, + 711.634, + 2307.13, + 930.6179999999999 + ], + "priority": 16, + "parents": [ + 143231 + ], + "children": [], + "area": 2024681.279544, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143232, + "strid": "4d486975-f563-4af8-b5d4-16fd73350a46", + "image_id": 206067, + "image_name": "17312.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2876.32, + 1679.707, + 344.9670000000001, + 46.81700000000001 + ], + "priority": 17, + "parents": [ + 143252 + ], + "children": [ + 143247, + 143239, + 143240, + 143248, + 143249, + 143246 + ], + "area": 4831374.83824, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions:" + }, + { + "id": 143246, + "strid": "7e018592-4b2c-4eb3-9533-6fca739519a5", + "image_id": 206067, + "image_name": "17312.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3244.972, + 1692.665, + 2049.3759999999997, + 40.740999999999985 + ], + "priority": 18, + "parents": [ + 143232 + ], + "children": [], + "area": 5492650.53038, + "iscrowd": 0, + "segmentation": [], + "text": "RVDB is expected to aid HTS investigations for known and novel viruses, thereby enhancing product safety, due to the" + }, + { + "id": 143247, + "strid": "4e6b02d7-171a-4126-85a7-a3407f2337cf", + "image_id": 206067, + "image_name": "17312.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2875.083, + 1743.051, + 2419.896, + 134.69299999999998 + ], + "priority": 19, + "parents": [ + 143232 + ], + "children": [], + "area": 5011416.298233, + "iscrowd": 0, + "segmentation": [], + "text": "inclusion in the database of all viral-related sequences, including sub-genomic viral fragments as well as endogenous retroviruses and\nretrotransposons, along with the reduction of overall cellular content. Ongoing annotation efforts will result in a high-quality database that will\nincrease confidence in obtaining accurate results from HTS data analysis." + }, + { + "id": 143239, + "strid": "bf44675e-b1be-4f1b-967e-e0770a7cdf9a", + "image_id": 206067, + "image_name": "17312.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3115.236, + 1922.841, + 818.0479999999998, + 111.61899999999991 + ], + "priority": 20, + "parents": [ + 143232 + ], + "children": [], + "area": 5990103.505476, + "iscrowd": 0, + "segmentation": [], + "text": "3. RVDB User Demography by Hits\n(Jan. 2020 ~ Sept. 2020)" + }, + { + "id": 143248, + "strid": "e1c25013-ec5d-4c58-98ce-02962d497e7c", + "image_id": 206067, + "image_name": "17312.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2850.799, + 2083.581, + 1365.7669999999998, + 847.902 + ], + "priority": 21, + "parents": [ + 143232 + ], + "children": [], + "area": 5939870.631219001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143240, + "strid": "105c7fb9-e0d0-495d-b190-49cc4cdfeff4", + "image_id": 206067, + "image_name": "17312.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4321.787, + 1921.71, + 925.5, + 104.81600000000003 + ], + "priority": 22, + "parents": [ + 143232 + ], + "children": [], + "area": 8305221.295770001, + "iscrowd": 0, + "segmentation": [], + "text": "4. A Bioinformatics Approach for Novel\nVirus Detection" + }, + { + "id": 143249, + "strid": "8fb75a01-7b31-4e1f-8698-f4cd0ba56355", + "image_id": 206067, + "image_name": "17312.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 4262.648, + 2060.509, + 1041.6260000000002, + 796.7240000000002 + ], + "priority": 23, + "parents": [ + 143232 + ], + "children": [], + "area": 8783224.567832, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143250, + "strid": "135af43f-18c0-468c-966b-4043230459c8", + "image_id": 206067, + "image_name": "17312.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4080.365, + 2971.561, + 312.8059999999996, + 48.44399999999996 + ], + "priority": 24, + "parents": [ + 143252 + ], + "children": [ + 143251 + ], + "area": 12125053.499765, + "iscrowd": 0, + "segmentation": [], + "text": "References:" + }, + { + "id": 143251, + "strid": "c80070aa-5be4-48aa-bcf8-5a1aaa105e67", + "image_id": 206067, + "image_name": "17312.png", + 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[], + "area": 12082.590042000002, + "iscrowd": 0, + "segmentation": [], + "text": "Hepatitis B prevention of mother to child transmission integrated into antenatal care services in Mozambique" + }, + { + "id": 137309, + "strid": "c4090dd7-3038-4524-9315-2c8b17f51e00", + "image_id": 205823, + "image_name": "16067.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 80.606, + 292.036, + 3562.883, + 162.58800000000002 + ], + "priority": 2, + "parents": [ + 137330 + ], + "children": [], + "area": 23539.853816, + "iscrowd": 0, + "segmentation": [], + "text": "Aude Nguyen, Natalia Tamayo Antabak2, Maira Chanase Rodrigues Marra’, Natercia Madeira?, Lucas Molfino2, Nelly Staderini’, Anne Loarec*\n‘Médecins Sans Frontiéres, Geneva, Switzerland; 2 Médecins sans Frontiéres, Maputo, Mozambique; $Ministry of Health, Maputo, Mozambique; *Epicentre, Paris, France; ° Geneva\nUniversity Hospital, Geneva, Switzerland" + }, + { + "id": 137310, + "strid": 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"children": [ + 137327 + ], + "area": 11415986.529374, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgments" + }, + { + "id": 137327, + "strid": "80241a00-cd80-47ea-a4da-57b934b9adef", + "image_id": 205823, + "image_name": "16067.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4060.379, + 2991.01, + 366.22299999999996, + 318.27700000000004 + ], + "priority": 20, + "parents": [ + 137314 + ], + "children": [], + "area": 12144634.19279, + "iscrowd": 0, + "segmentation": [], + "text": "We would like to\nthank all the staff\ninvolved in these\nactivities, the\npatients and the\nMinistry of Health." + }, + { + "id": 137315, + "strid": "f69d96a2-1ab3-4f2f-941f-2a93a0d6b3e1", + "image_id": 205823, + "image_name": "16067.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4874.338, + 2815.722, + 258.28300000000036, + 43.751000000000204 + ], + "priority": 21, + "parents": [ + 137330 + ], + "children": [ + 137328 + ], + "area": 13724780.742036, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 137328, + "strid": "7e82dfd3-36b3-428d-8f8d-fbb48f7a0076", + "image_id": 205823, + "image_name": "16067.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 4609.761, + 2937.044, + 792.9489999999996, + 475.76900000000023 + ], + "priority": 22, + "parents": [ + 137315 + ], + "children": [], + "area": 13539070.886484, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 126079, + "strid": "63020763-ba43-45c2-b60e-f781d0dda312", + "image_id": 205410, + "image_name": "15091.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 2358.46, + 47.06, + 310.46000000000004, + 232.85000000000002 + ], + "priority": -1, + "parents": [], + "children": [ + 126076, + 126059, + 126061, + 126062, + 126060, + 126065, + 126077, + 126064, + 126078, + 126063 + ], + "area": 110989.1276, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 126059, + "strid": "a3bdcd02-bc43-420e-8eb3-c998cbf84b7c", + "image_id": 205410, + "image_name": "15091.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 67.996, + 27.637, + 2231.178, + 655.252 + ], + "priority": 1, + "parents": [ + 126079 + ], + "children": [], + "area": 1879.205452, + "iscrowd": 0, + "segmentation": [], + "text": "Proof-of-concept =\nTeale Teall oom al ani-] a ee\ngenomics variant calling deal ine\nusing BioContainers an Ebay" + }, + { + "id": 126065, + "strid": "f06ebe3d-3004-423b-a8cd-edb199b00db0", + "image_id": 205410, + "image_name": "15091.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 35.978, + 750.568, + 3214.171, + 230.33899999999994 + ], + "priority": 2, + "parents": [ + 126079 + ], + "children": [], + "area": 27003.935504, + "iscrowd": 0, + "segmentation": [], + "text": "In the context of the Rare Disease Community, variant-calling workflows need to be validated, benchmarked and audited for the sake of quality and\nreproducibility. Software containers are suitable solutions to preserve reproducibility since they can run in isolation from other software on the same\nmachine, in a different OS version (or flavor), preserving the same exact configuration, codebase and dependencies present in the initial image. In other\nwords containers technology facilitate reproducibility of computations and reuse of software tools in workflows." + }, + { + "id": 126060, + "strid": "a02a2f6a-fed6-4ac1-b14f-ce94f78e6e67", + "image_id": 205410, + "image_name": "15091.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 352.538, + 1009.924, + 1244.193, + 91.49499999999989 + ], + "priority": 3, + "parents": [ + 126079 + ], + "children": [ + 126066 + ], + "area": 356036.587112, + "iscrowd": 0, + "segmentation": [], + "text": "ELIXIR, BioContainers and Galaxy" + }, + { + "id": 126066, + "strid": "e9ea02e7-7c1f-4475-a512-61698b17896c", + "image_id": 205410, + "image_name": "15091.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 38.825, + 1113.289, + 1557.368, + 707.011 + ], + "priority": 4, + "parents": [ + 126060 + ], + "children": [], + "area": 43223.445425000005, + "iscrowd": 0, + "segmentation": [], + "text": "ELIXIR is on the forefront of the utilization of containers and is\ncollaborating across Europe in order to establish an infrastructure to allow\nend users to find, generate and benchmark software containers.\n\nPart of this infrastructure are ELIXIR initiatives such as BioContainers,\nOpenEBench, Bio.tools, and many more.\n\nGalaxy is a very popular platform used in Life Science, as in many other\nfields, to run analysis of large datasets typically in pipelines of tools or\nworkflows.\n\nBioContainers is “community-driven project that provides the\ninfrastructure and basic guidelines to create, manage and distribute\nbioinformatics packages and containers. BioContainers is based on the\npopular frameworks Conda, Docker and Singularity.”" + }, + { + "id": 126061, + "strid": "8a888b5e-2d19-4acc-8d27-fd9b4be0c3ed", + "image_id": 205410, + "image_name": "15091.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1265.8, + 1819.926, + 328.94100000000003, + 69.26299999999992 + ], + "priority": 5, + "parents": [ + 126079 + ], + "children": [ + 126067 + ], + "area": 2303662.3307999996, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 126067, + "strid": "90eb02f4-d296-43da-a913-63511988f417", + "image_id": 205410, + "image_name": "15091.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 37.321, + 1919.323, + 1557.785, + 374.4469999999999 + ], + "priority": 6, + "parents": [ + 126061 + ], + "children": [], + "area": 71631.053683, + "iscrowd": 0, + "segmentation": [], + "text": "We present a proof-of-concept workflow trom Laurie et al 2016 [1], based on\nBioContainers and Galaxy. It includes one aligner, one BAM processor and one\nvariant caller, see Fig. 1.\n\nMore specifically: Burrows Wheeler Aligner (BWA) is used to map NGS reads on\nthe reference genome, the samtools and bcftools packages to process the BAM\nfiles and call variants, respectively. The tools, installed from the main Galaxy\ntoolshed, see Fig. 2, were configured manually with Biocontainers images." + }, + { + "id": 126063, + "strid": "73571248-346d-4872-86e7-4a47fee1cd55", + "image_id": 205410, + "image_name": "15091.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1327.784, + 2317.4, + 265.8510000000001, + 69.41899999999987 + ], + "priority": 7, + "parents": [ + 126079 + ], + "children": [ + 126068 + ], + "area": 3077006.6416, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 126068, + "strid": "2dcea223-cdcd-46cf-82bf-ffea153c3f82", + "image_id": 205410, + "image_name": "15091.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 37.752, + 2427.873, + 1557.448, + 463.75300000000016 + ], + "priority": 8, + "parents": [ + 126063 + ], + "children": [], + "area": 91657.06149600001, + "iscrowd": 0, + "segmentation": [], + "text": "To test the pipeline we used data from the NA12878 Platinum Genome FASTO files\n\nand the hg37 human genome as reference [2]. Tools were used with standard\n\nparameters.\n\nWe compared our results with the gold-standard VCF generated by the U.S.\n\nNational Institute of Standards and Technology (NIST) and the Genome in a Bottle\n\nConsortium [3] obtaining results on SNPs comparable with the golden standard:\nTrue Positive Rate (=Recall) = 99.7%\n\nPositive Predictive Value (=Precision) = 99.8%." + }, + { + "id": 126076, + "strid": "66f8e5a0-0af2-470a-91c7-7a5c8dbc2b86", + "image_id": 205410, + "image_name": "15091.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1669.028, + 1035.133, + 1576.8710000000003, + 467.8799999999999 + ], + "priority": 9, + "parents": [ + 126079 + ], + "children": [ + 126071 + ], + "area": 1727665.9607240001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 126071, + "strid": "c8ea0d6f-984c-4ebd-967d-c1ce0e97c9ab", + "image_id": 205410, + "image_name": "15091.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2024.548, + 1520.612, + 865.626, + 44.49199999999996 + ], + "priority": 10, + "parents": [ + 126076 + ], + "children": [], + "area": 3078551.983376, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 1 Schematic representation of the workflow" + }, + { + "id": 126077, + "strid": "16757d5a-d1a3-4372-a2e5-6c238b325c63", + "image_id": 205410, + "image_name": "15091.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1669.007, + 1632.926, + 1576.8030000000003, + 414.81899999999996 + ], + "priority": 11, + "parents": [ + 126079 + ], + "children": [ + 126072 + ], + "area": 2725364.924482, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 126072, + "strid": "2327b470-2a78-4747-b6bf-a2ac4cfb46b3", + "image_id": 205410, + "image_name": "15091.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2088.871, + 2065.861, + 736.4960000000001, + 43.19999999999982 + ], + "priority": 12, + "parents": [ + 126077 + ], + "children": [], + "area": 4315317.132931, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 2 Workflow representation in Galaxy" + }, + { + "id": 126062, + "strid": "a02e3f90-5193-40fb-80cd-701649842010", + "image_id": 205410, + "image_name": "15091.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1683.548, + 2137.789, + 386.82500000000005, + 67.35100000000011 + ], + "priority": 13, + "parents": [ + 126079 + ], + "children": [ + 126069 + ], + "area": 3599070.3953720005, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion" + }, + { + "id": 126069, + "strid": "69f0e7c8-ca47-4c1a-9c2f-dff8770cb2a1", + "image_id": 205410, + "image_name": "15091.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1677.974, + 2243.83, + 1557.954, + 585.7150000000001 + ], + "priority": 14, + "parents": [ + 126062 + ], + "children": [], + "area": 3765088.40042, + "iscrowd": 0, + "segmentation": [], + "text": "Containerized workflows provides a prominent advantage: the same fine tuned\nsteps of the computation can be available to each site that requires them\n\nand can be replicated even if the execution environments differ.\n\nThere are, however, few issues still to be addressed: potential version mismatch\ncaused by manual tool configuration, and the potential incompatibility between\nthe command line specified in the Galaxy tool and the container.\n\nBoth issues are being worked on by providing automatic container creation via\nConda, Mulled and Involucro.\n\nIn this way the exact same version and container will be used transparently (still\nbeta at the moment of writing)." + }, + { + "id": 126064, + "strid": "918a8435-459c-48b5-aae8-c7e27c7befd4", + "image_id": 205410, + "image_name": "15091.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 963.95, + 2991.763, + 630.395, + 73.8739999999998 + ], + "priority": 15, + "parents": [ + 126079 + ], + "children": [ + 126075, + 126070 + ], + "area": 2883909.94385, + "iscrowd": 0, + "segmentation": [], + "text": "Future directions" + }, + { + "id": 126070, + "strid": "b88f0a33-e17c-45c3-ade8-6fed400c37b8", + "image_id": 205410, + "image_name": "15091.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 37.803, + 3102.874, + 1557.8470000000002, + 278.7539999999999 + ], + "priority": 16, + "parents": [ + 126064 + ], + "children": [], + "area": 117297.94582199998, + "iscrowd": 0, + "segmentation": [], + "text": "This proof-of-concept workflow is a stepping stone towards an effort in\nbenchmarking different workflow managers in executing a well established variant\ncalling pipeline, see Fig. 3. The same workflow will be implemented in NextFLow,\nCWL and Galaxy and the tools included in the workflow will run in containers [4].\nThe results will be available in OpenEBench." + }, + { + "id": 126075, + "strid": "ea38bed7-4491-418a-b7c9-636dd1273aab", + "image_id": 205410, + "image_name": "15091.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1774.227, + 2997.66, + 1381.9639999999997, + 943.136 + ], + "priority": 17, + "parents": [ + 126064 + ], + "children": [ + 126073 + ], + "area": 5318529.30882, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 126073, + "strid": "317a8a03-db52-4295-a04b-a896cde5806a", + "image_id": 205410, + "image_name": "15091.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2053.441, + 3972.967, + 806.0799999999999, + 93.8710000000001 + ], + "priority": 18, + "parents": [ + 126075 + ], + "children": [], + "area": 8158253.329446999, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 3 RD-Connect variant calling pipeline\nR. Tonda, S. Laurie, S.Berltran, et al. from [4]" + }, + { + "id": 126078, + "strid": "6eaa51d6-31a7-4a70-a699-e2d7392a1d97", + "image_id": 205410, + "image_name": "15091.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1179.268, + 3773.666, + 389.4069999999999, + 63.84900000000016 + ], + "priority": 19, + "parents": [ + 126079 + ], + "children": [ + 126074 + ], + "area": 4450163.556488, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 126074, + "strid": "31c11099-b783-4937-8b29-4474c5fc2419", + "image_id": 205410, + "image_name": "15091.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 62.214, + 3871.666, + 1467.966, + 257.08200000000033 + ], + "priority": 20, + "parents": [ + 126078 + ], + "children": [], + "area": 240871.828524, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 24496, + "strid": "a7384b83-9e6c-45e8-b453-557dde8b3014", + "image_id": 201483, + "image_name": "117192.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 96.86, + 229.91, + 325.24, + 192.19000000000003 + ], + "priority": -1, + "parents": [], + "children": [ + 24473, + 24470, + 24475, + 24468, + 24476, + 24469, + 24474, + 24472, + 24495 + ], + "area": 22269.082599999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 24468, + "strid": "bf933651-2737-4b90-bfc5-ce0cb31c31c3", + "image_id": 201483, + "image_name": "117192.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 861.886, + 38.867, + 2812.632, + 207.78 + ], + "priority": 1, + "parents": [ + 24496 + ], + "children": [], + "area": 33498.923162, + "iscrowd": 0, + "segmentation": [], + "text": "High blood cytokine levels are linked to decreased verbal fluency and\nBroca’s area volume in schizophrenia" + }, + { + "id": 24469, + "strid": "85899a7d-344c-4ec7-bf04-d2f1d7d27985", + "image_id": 201483, + "image_name": "117192.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 606.713, + 295.791, + 3517.298, + 156.861 + ], + "priority": 2, + "parents": [ + 24496 + ], + "children": [], + "area": 179460.24498299998, + "iscrowd": 0, + "segmentation": [], + "text": "Thomas W. Weickert 1:23, Stu G. Fillman 1.43, Rhoshel Lenroot '2, Jason Bruggemann *%, Cynthia Shannon Weickert 1:23\n'School of Psychiatry, University of New South Wales, 7Neuroscience Research Australia, $Schizophrenia Research Institute" + }, + { + "id": 24470, + "strid": "07492f40-1a47-4a35-bf4b-2fc7f10ebb59", + "image_id": 201483, + "image_name": "117192.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 16.762, + 464.718, + 1611.7, + 1223.858 + ], + "priority": 3, + "parents": [ + 24496 + ], + "children": [], + "area": 7789.603116, + "iscrowd": 0, + "segmentation": [], + "text": "Background: Psychotic symptoms, cognitive impairment, and treatment\nresponse are variable in schizophrenia, highlighting heterogeneity in the etiology\nand presentation of the illness and a critical need for novel treatment approaches\ntargeting subgroups with shared features. One subgroup of people with\nschizophrenia is characterized by those patients with increased inflammation.\nCytokines initiate immunological responses and one of the leading theories\nregarding the etiology of schizophrenia based on epidemiology suggests that\nearly maternal inflammation may produce abnormal neurodevelopment leading to\nincreased risk for schizophrenia in the offspring. There is increasing evidence that\ncytokines and in particular Interleukin 1-beta (IL-1B) may be altered in adults with\nschizophrenia. IL-18 mRNA and protein levels have been shown to be\nsignificantly increased in serum, plasma, cerebrospinal fluid and brain tissue in\nsubsets of chronically ill adults with schizophrenia and first episode psychosis.\nFurther support for immune dysregulation in schizophrenia comes from genetic\nstudies in which allelic variation in the IL-1B gene has been associated with a\ndiagnosis of schizophrenia and IL-16 risk alleles have been associated with\nabnormal prefrontal cortex activity and reduced prefrontal gray matter in\nschizophrenia. In rodents, pregnant dam exposure to II-B and TNFa reduced\ndendrites and dendritic length in pups. Stress triggers symptoms in schizophrenia\nand, in rodents, increases IL-18 in the hippocampus and IL-18 can inhibit adult\nhippocampal neurogenesis which can be reversed by blockade of IL-1.\nPeripheral and central IL-18 administration elicits anhedonia and deficits in social\ninteraction and memory, which are similar to deficits found in schizophrenia." + }, + { + "id": 24473, + "strid": "0be1862e-7701-4798-9c9e-2a2c0b48e233", + "image_id": 201483, + "image_name": "117192.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 601.944, + 1704.373, + 380.41599999999994, + 70.97299999999996 + ], + "priority": 4, + "parents": [ + 24496 + ], + "children": [ + 24477 + ], + "area": 1025937.101112, + "iscrowd": 0, + "segmentation": [], + "text": "Hypotheses" + }, + { + "id": 24477, + "strid": "d2bae405-f0a9-4847-a29e-3cca7d452452", + "image_id": 201483, + "image_name": "117192.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 69.098, + 1793.158, + 1391.504, + 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schizoaffective disorder\n(all on antipsychotics) and 42 age and sex matched healthy controls we\nassayed cytokine (IL1B, IL8, IL6, IL18 and IL2) mRNA levels from white\nblood cells by qPCR, cognition (4 subtest version of WAIS-III |Q and\nCOWAT verbal fluency) and structural MRI." + }, + { + "id": 24494, + "strid": "617dd4fd-c67f-4546-a2a8-580cd730380c", + "image_id": 201483, + "image_name": "117192.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 18.766, + 2890.168, + 1633.903, + 773.9540000000002 + ], + "priority": 8, + "parents": [ + 24474 + ], + "children": [ + 24485 + ], + "area": 54236.892688, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 24485, + "strid": "d91cbec1-8970-40e4-baaf-bfe5ab9080d3", + "image_id": 201483, + "image_name": "117192.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 33.884, + 2826.12, + 1466.705, + 61.86400000000003 + ], + "priority": 9, + "parents": [ + 24494 + ], + "children": [], + "area": 95760.25008, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1: Demographics of schizophrenia and matched control subjects in the New South Wales Tissue Resource Center\npost-mortem brain tissue cohort." + }, + { + "id": 24478, + "strid": "bf40b3d3-c673-42d4-bb6b-f34c872f19b0", + "image_id": 201483, + "image_name": "117192.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 26.084, + 3741.47, + 1683.801, + 965.2270000000003 + ], + "priority": 10, + "parents": [ + 24474 + ], + "children": [], + "area": 97592.50348, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 24475, + "strid": "eb567185-9f37-4d26-a410-1d888ad3284a", + "image_id": 201483, + "image_name": "117192.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2204.63, + 472.717, + 243.5920000000001, + 70.42200000000003 + ], + "priority": 11, + "parents": [ + 24496 + ], + "children": [ + 24493, + 24490, + 24479, + 24491, + 24483, + 24482, + 24481, + 24484, + 24492 + ], + "area": 1042166.07971, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 24484, + "strid": "fe35d46c-d473-433c-b7e7-204edf7d149f", + "image_id": 201483, + "image_name": "117192.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1656.361, + 566.947, + 1346.456, + 704.7770000000002 + ], + "priority": 12, + "parents": [ + 24475 + ], + "children": [], + "area": 939068.8998670001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 24493, + "strid": "7bd53c2e-1aa4-44c4-ba88-2b6efe1d409b", + "image_id": 201483, + "image_name": "117192.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1875.023, + 1388.025, + 905.5469999999998, + 981.2779999999998 + ], + "priority": 13, + "parents": [ + 24475 + ], + "children": [ + 24487 + ], + "area": 2602578.799575, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 24487, + "strid": "ddc7f065-b6bf-46fd-967a-67867ce51bca", + "image_id": 201483, + "image_name": "117192.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1675.117, + 2418.249, + 1385.488, + 166.41699999999992 + ], + "priority": 14, + "parents": [ + 24493 + ], + "children": [], + "area": 4050850.0101329996, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. Subgroups of patients and controls\ncharacterized by high and low cytokine levels in brain and\nblood." + }, + { + "id": 24483, + "strid": "7ac19967-0b30-4d21-a2ba-38ef6b2f74d1", + "image_id": 201483, + "image_name": "117192.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1694.451, + 2624.597, + 1353.275, + 176.07699999999977 + ], + "priority": 15, + "parents": [ + 24475 + ], + "children": [], + "area": 4447251.011247001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 24490, + "strid": "a9c0151f-0e8c-4d29-8bed-51cd01c0e717", + "image_id": 201483, + "image_name": "117192.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1984.382, + 2843.613, + 788.8470000000002, + 1352.6280000000002 + ], + "priority": 16, + "parents": [ + 24475 + ], + "children": [ + 24486 + ], + "area": 5642814.452165999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 24486, + "strid": "f743642d-49b2-45f9-af12-87a7eb863468", + "image_id": 201483, + "image_name": "117192.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1728.807, + 4209.743, + 1334.718, + 113.51000000000022 + ], + "priority": 17, + "parents": [ + 24490 + ], + "children": [], + "area": 7277833.166601, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2. Peripheral IL-1B mRNA levels in schizophrenia\nand healthy control groups, ** p < .009." + }, + { + "id": 24479, + "strid": "f2ff8684-92ed-427a-9b51-2fb4cc383e83", + "image_id": 201483, + "image_name": "117192.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1765.49, + 4350.262, + 1344.4750000000001, + 356.4350000000004 + ], + "priority": 18, + "parents": [ + 24475 + ], + "children": [], + "area": 7680344.058379999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 24492, + "strid": "586bfcf6-8073-4ad3-a399-82f1042d90d4", + "image_id": 201483, + "image_name": "117192.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3236.733, + 748.934, + 1339.2569999999996, + 1020.5989999999999 + ], + "priority": 19, + "parents": [ + 24475 + ], + "children": [ + 24488 + ], + "area": 2424099.392622, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 24488, + "strid": "1f829c07-4bd1-42cf-8ab5-3a8eb721228a", + "image_id": 201483, + "image_name": "117192.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 3216.456, + 471.873, + 1446.558, + 246.858 + ], + "priority": 20, + "parents": [ + 24492 + ], + "children": [], + "area": 1517758.742088, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3. Correlation between verbal fluency (as measured\nby COWAT letter fluency) and peripheral IL-1B levels in\npeople with schizophrenia with high and low cytokine levels.\n\nCOWAT and IL1B mRNA Expression in Cytokine Groups" + }, + { + "id": 24482, + "strid": "eebc3ca6-3f68-4700-a9f3-a98451c25ccc", + "image_id": 201483, + "image_name": "117192.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3313.804, + 1809.2, + 1252.3360000000002, + 114.29999999999995 + ], + "priority": 21, + "parents": [ + 24475 + ], + "children": [], + "area": 5995334.1968, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 24491, + "strid": "57a0fdd3-9455-402b-af94-00e2c2b78add", + "image_id": 201483, + "image_name": "117192.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3296.899, + 2155.043, + 1223.3809999999999, + 1089.6780000000003 + ], + "priority": 22, + "parents": [ + 24475 + ], + "children": [ + 24489 + ], + "area": 7104959.111657, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 24489, + "strid": "4298f7c9-4942-49ba-9deb-7ecc7869aabb", + "image_id": 201483, + "image_name": "117192.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 3291.105, + 1961.709, + 1358.9559999999997, + 181.5690000000002 + ], + "priority": 23, + "parents": [ + 24491 + ], + "children": [], + "area": 6456190.298445, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 4. Significant difference in Broca’s area volume in\npatients with schizophrenia who have high levels of\nperipheral cytokines" + }, + { + "id": 24481, + "strid": "d9a83858-c33a-45ba-8f89-88b854c1da47", + "image_id": 201483, + "image_name": "117192.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3217.34, + 3274.85, + 1449.478, + 415.462 + ], + "priority": 24, + "parents": [ + 24475 + ], + "children": [], + "area": 10536305.899, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 24476, + "strid": "e6b69498-3e42-4fd4-9f57-407e36ddf5ca", + "image_id": 201483, + "image_name": "117192.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3771.348, + 3727.401, + 408.201, + 70.95499999999993 + ], + "priority": 25, + "parents": [ + 24496 + ], + "children": [ + 24480 + ], + "area": 14057326.306548, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 24480, + "strid": "d6f2b9ce-0259-409e-9778-d7e3f0e099e7", + "image_id": 201483, + "image_name": "117192.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3277.62, + 3807.491, + 1374.8230000000003, + 471.6099999999997 + ], + "priority": 26, + "parents": [ + 24476 + ], + "children": [], + "area": 12479508.65142, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 24472, + "strid": "d2f7c46f-8715-4e94-8aa1-ece6518e1158", + "image_id": 201483, + "image_name": "117192.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3291.736, + 4304.258, + 1299.9970000000003, + 298.8249999999998 + ], + "priority": 27, + "parents": [ + 24496 + ], + "children": [], + "area": 14168481.011888, + "iscrowd": 0, + "segmentation": [], + "text": "Reference\n1 Fillman S, ...Weickert CS. 2013. Increased inflammatory\nmarkers identified in the dorsolateral prefrontal cortex of\nindividuals with schizophrenia. Mol Psychiatry\ndoi:10.1038/mp.2012.110" + }, + { + "id": 24495, + "strid": "efd49cb0-c169-4a22-bde3-b6429452761e", + "image_id": 201483, + "image_name": "117192.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3426.662, + 4643.553, + 793.1860000000001, + 44.70300000000043 + ], + "priority": 28, + "parents": [ + 24496 + ], + "children": [], + "area": 15911886.610086, + "iscrowd": 0, + "segmentation": [], + "text": "All authors report no conflicts of interest." + }, + { + "id": 178561, + "strid": "82973315-9902-424e-9187-4b170447d2d4", + "image_id": 207469, + "image_name": "8225.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 12.41, + 9.23, + 39.34, + 20.52 + ], + "priority": -1, + "parents": [], + "children": [ + 178549, + 178556, + 178550, + 178552, + 178557, + 178560, + 178559, + 178551 + ], + "area": 114.5443, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178549, + "strid": "aee3c982-8e74-4471-85ac-162110b95c36", + "image_id": 207469, + "image_name": "8225.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 26.832, + 39.778, + 692.119, + 51.248 + ], + "priority": 1, + "parents": [ + 178561 + ], + "children": [], + "area": 1067.323296, + "iscrowd": 0, + "segmentation": [], + "text": "Chromosomal, molecular and morphological analysis of a human\nembryo with homogeneous trisomy of chromosome 8" + }, + { + "id": 178550, + "strid": "9bac8242-4df4-4296-b8bf-1c28d408d47e", + "image_id": 207469, + "image_name": "8225.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 74.298, + 111.237, + 598.379, + 40.16299999999998 + ], + "priority": 2, + "parents": [ + 178561 + ], + "children": [], + "area": 8264.686626, + "iscrowd": 0, + "segmentation": [], + "text": "Géraldine Goudefroye’, Jessica Guirchon’, Catherine Ozilou”, Nicole Morichon-Delvallez’, Amold Munnich',\nMichel Vekemans\"2, Tania Attis-Bitach':? and Heather Etchevers*\n‘Service de Cylogénétique’ end INSERM U303', Hopital Necker — Enfants Matedes, 149 rue de Séwee, 75743 Peri Cedex 18, France" + }, + { + "id": 178551, + "strid": "1deccb9c-0485-468f-94a5-b8419edf507a", + "image_id": 207469, + "image_name": "8225.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 60.478, + 186.607, + 633.139, + 73.72 + ], + "priority": 3, + "parents": [ + 178561 + ], + "children": [], + "area": 11285.618146, + "iscrowd": 0, + "segmentation": [], + "text": "Our group studies developmental gene expression in normal human embryos obtained from voluntary interruptions of\npregnancy, in accordance with ethical guidelines established by French law. A chromosomal anomaly was suspected in one\nhuman embryo at Carnegie stage 11 (-25 days of development) on the basis of abnormal morphology. The embryo had\nsevere malformations of the cardiovascular and central nervous systems. The karyotype of its chorionic villus sample showed\na homogeneous trisomy of chromosome 8, whereas FQ-PCR analysis confirmed the meiotic origin of the non-" + }, + { + "id": 178556, + "strid": "258e39ba-dc19-422b-baae-3149fe9220dd", + "image_id": 207469, + "image_name": "8225.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 117.6, + 295.944, + 158.371, + 257.607 + ], + "priority": 4, + "parents": [ + 178561 + ], + "children": [ + 178553 + ], + "area": 34803.0144, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178553, + "strid": "00ed8190-2a2d-4be5-af55-6405580d14ad", + "image_id": 207469, + "image_name": "8225.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 76.924, + 557.018, + 244.41100000000003, + 50.972999999999956 + ], + "priority": 5, + "parents": [ + 178556 + ], + "children": [], + "area": 42848.052632000006, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 178557, + "strid": "a0476011-3a42-46c3-82a3-a95a0c7a9926", + "image_id": 207469, + "image_name": "8225.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 360.172, + 291.424, + 309.96000000000004, + 230.452 + ], + "priority": 6, + "parents": [ + 178561 + ], + "children": [ + 178554 + ], + "area": 104962.764928, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178554, + "strid": "ed696799-3d15-4419-a6a6-4f4097670217", + "image_id": 207469, + "image_name": "8225.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 357.33, + 533.022, + 314.107, + 73.02700000000004 + ], + "priority": 7, + "parents": [ + 178557 + ], + "children": [], + "area": 190464.75126000002, + "iscrowd": 0, + "segmentation": [], + "text": "fang wes ra maps rr ne ed Rn heat aa\nfren ns sna inane eager sce 1 ata a\nSe pi a tcp er oc om a\nsaya He py ach fm pong: aap sar\"" + }, + { + "id": 178559, + "strid": "b98d79fb-a6b6-458a-a6f2-17844e24d476", + "image_id": 207469, + "image_name": "8225.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 67.772, + 654.775, + 271.17, + 223.10699999999997 + ], + "priority": 8, + "parents": [ + 178561 + ], + "children": [ + 178558 + ], + "area": 44375.4113, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178558, + "strid": "8b0b2953-d361-40b3-9980-55cc086eca42", + "image_id": 207469, + "image_name": "8225.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 121.193, + 654.855, + 157.90300000000002, + 8.613000000000056 + ], + "priority": 9, + "parents": [ + 178559 + ], + "children": [], + "area": 79363.842015, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 178560, + "strid": "6850bf11-4672-4394-a8b5-8d5fd8dfbf5b", + "image_id": 207469, + "image_name": "8225.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 373.358, + 628.667, + 157.61600000000004, + 247.12800000000004 + ], + "priority": 10, + "parents": [ + 178561 + ], + "children": [ + 178555 + ], + "area": 234717.85378600002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178555, + "strid": "25ebf777-8894-4f23-8da4-14a99b5d58f3", + "image_id": 207469, + "image_name": "8225.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 545.345, + 740.527, + 118.34900000000005, + 42.297000000000025 + ], + "priority": 11, + "parents": [ + 178560 + ], + "children": [], + "area": 403842.69681500003, + "iscrowd": 0, + "segmentation": [], + "text": "ee be beeen\npas 800. and Des y=2e seman" + }, + { + "id": 178552, + "strid": "aa8e4902-4924-4b07-9051-13eda04261ad", + "image_id": 207469, + "image_name": "8225.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 59.81, + 899.701, + 633.097, + 133.6479999999999 + ], + "priority": 12, + "parents": [ + 178561 + ], + "children": [], + "area": 53811.11681000001, + "iscrowd": 0, + "segmentation": [], + "text": "Only a few cases of human trisomy 8 have been reported to date in children or adults. With one recent neonatal exception, the\nother previous cases all showed mosaicism due to mitotic non-disjunction early during zygotic development. Our case\ndemonstrates that homogeneous trisomy 8 is compatible with implantation and early embryogenesis. Nonetheless, by\nCamegie stage 11, the heart was bifid, yolk sac vessels were abnormally dilated, the prosencephalon and branchial arches\nwere absent and the somites were small and irregularly shaped. These severe systemic malformations are not compatible with\nfurther development, confirming the lethality of trisomy 8 of meiotic origin. In addition, this case justifies the systematic\nkaryotyping of human embryos used for research purposes, as we have observed other trisomies in apparently normal cases;\nlikewise, chromosomal abnormalities may be responsible for other occasional malformations observed in human embryos\nreceived for study." + }, + { + "id": 103527, + "strid": "232a154e-1a01-4b97-9c12-9bf9f656ced1", + "image_id": 204499, + "image_name": "122237.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 37.09, + 151.75, + 190.17, + 224.74 + ], + "priority": -1, + "parents": [], + "children": [ + 103524, + 103519, + 103511, + 103516, + 103515, + 103518, + 103523, + 103520, + 103514, + 103521, + 103525, + 103522, + 103517, + 103512, + 103513, + 103526 + ], + "area": 5628.4075, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 103511, + "strid": "06b44423-f643-4d19-acb3-f18dc9834179", + "image_id": 204499, + "image_name": "122237.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 83.191, + 34.879, + 2320.313, + 251.244 + ], + "priority": 1, + "parents": [ + 103527 + ], + "children": [], + "area": 2901.618889, + "iscrowd": 0, + "segmentation": [], + "text": "CTLA-4 Checkpoint blockade in Breast Cancer\nA case in point report" + }, + { + "id": 103512, + "strid": "886f9950-867a-4cf8-b682-29711997d4fc", + "image_id": 204499, + "image_name": "122237.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 83.191, + 312.725, + 1566.581, + 127.10000000000002 + ], + "priority": 2, + "parents": [ + 103527 + ], + "children": [], + "area": 26015.905475000003, + "iscrowd": 0, + "segmentation": [], + "text": "Chiara Dellepiane «); Michela Lia », and Mario Roberto Sertoli «.).\n«) IRCCS San Martino IST, Genoa University - 2 EORTC" + }, + { + "id": 103513, + "strid": "e4a0dc8d-0ab8-4a59-b453-fe31ef18e9ce", + "image_id": 204499, + "image_name": "122237.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 78.658, + 532.954, + 1001.7879999999999, + 230.827 + ], + "priority": 3, + "parents": [ + 103527 + ], + "children": [], + "area": 41921.095731999994, + "iscrowd": 0, + "segmentation": [], + "text": "Background: A patient concomitantly affected\nby breast cancer and melanoma is presented\nin order to contribute to the ongoing debate on\nbreast cancer immunotherapy. (1,2)" + }, + { + "id": 103514, + "strid": "ec66de27-956f-43b6-af4b-5a9eba35b270", + "image_id": 204499, + "image_name": "122237.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 75.137, + 880.733, + 1036.867, + 933.741 + ], + "priority": 4, + "parents": [ + 103527 + ], + "children": [], + "area": 66175.635421, + "iscrowd": 0, + "segmentation": [], + "text": "etl ocean\n\nae eda aS aelt os" + }, + { + "id": 103516, + "strid": "779fb761-52f2-43ef-9d02-40cc57cf6830", + "image_id": 204499, + "image_name": "122237.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1252.039, + 522.345, + 1226.637, + 587.241 + ], + "priority": 5, + "parents": [ + 103527 + ], + "children": [], + "area": 653996.3114550001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 103521, + "strid": "f8e31f7d-3d37-40b1-acf0-fec4ba8c0683", + "image_id": 204499, + "image_name": "122237.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1254.148, + 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"strid": "7cd778e1-8a31-494e-9c5d-32615bac5564", + "image_id": 204499, + "image_name": "122237.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2611.245, + 514.299, + 1241.725, + 222.59899999999993 + ], + "priority": 9, + "parents": [ + 103527 + ], + "children": [], + "area": 1342960.692255, + "iscrowd": 0, + "segmentation": [], + "text": "At this point Ipilimumab (3) was available and CR of liver,\nlung, and dermic metastases was obtained after 4 cycles,\nwhile bone lesions remained stable and considered\nbreast cancer." + }, + { + "id": 103526, + "strid": "cb6e60cb-1104-4965-ba56-379f324b871f", + "image_id": 204499, + "image_name": "122237.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2625.162, + 764.093, + 565.8830000000003, + 556.901 + ], + "priority": 10, + "parents": [ + 103527 + ], + "children": [], + "area": 2005867.9080659999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 103525, + "strid": 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], + "children": [], + "area": 393440.106024, + "iscrowd": 0, + "segmentation": [], + "text": "Due thanks to the Mentor-Student Research Link program —a program\nestablished by Healtheare reform of Egypt (HRE)- without which, this work\ncruuid lave nega Poae cscnenptiched" + }, + { + "id": 45322, + "strid": "8d48ac1c-ca44-4b4e-bc18-9e85fc67bf84", + "image_id": 202273, + "image_name": "118449.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 586.178, + 967.273, + 63.49800000000005, + 12.914999999999964 + ], + "priority": 26, + "parents": [ + 45342 + ], + "children": [ + 45341 + ], + "area": 566994.152594, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 45341, + "strid": "28417d7d-598d-467e-bcd8-63b2a0779618", + "image_id": 202273, + "image_name": "118449.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 427.268, + 983.711, + 368.7269999999999, + 112.05400000000009 + ], + "priority": 27, + "parents": [ + 45322 + ], + "children": [], + "area": 420308.23154799995, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 13409, + "strid": "1e562c06-cb79-4011-9caf-99bada77c3ab", + "image_id": 201037, + "image_name": "11513.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 50.56, + 64.28, + 241.37, + 107.27000000000001 + ], + "priority": -1, + "parents": [], + "children": [ + 13412, + 13423, + 13410, + 13414, + 13420, + 13417, + 13421, + 13416, + 13411 + ], + "area": 3249.9968000000003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 13410, + "strid": "4c271711-ee42-4769-9059-848d29c856ff", + "image_id": 201037, + "image_name": "11513.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 1908.433, + 89.754, + 1280.9679999999998, + 268.832 + ], + "priority": 1, + "parents": [ + 13409 + ], + "children": [], + "area": 171289.495482, + "iscrowd": 0, + "segmentation": [], + "text": "Title: “Role of environmental filters\nin the restoration of degraded peri-\nurban ecosystems”" + }, + { + "id": 13411, + "strid": "0c5f7214-bc70-49cf-aff7-f8c74bc859df", + "image_id": 201037, + "image_name": "11513.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 417.048, + 45.192, + 1298.194, + 140.953 + ], + "priority": 2, + "parents": [ + 13409 + ], + "children": [], + "area": 18847.233216, + "iscrowd": 0, + "segmentation": [], + "text": "Authors: Pawel Waryszak, Joseph B. Fontaine, Rachel J. Standish, Phil\nLadd and Neal J. Enright, Environmental & Conservation Sciences,\nMurdoch University, Perth, Western Australia" + }, + { + "id": 13412, + "strid": "a00de52f-77dc-4bb3-98eb-a6bfbd4deafa", + "image_id": 201037, + "image_name": "11513.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 204.943, + 262.448, + 315.44100000000003, + 48.44900000000001 + ], + "priority": 3, + "parents": [ + 13409 + ], + "children": [ + 13413 + ], + "area": 53786.880464, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 13413, + "strid": "e4c9ab75-24d9-40b2-b9cf-84d654f3e1e1", + "image_id": 201037, + "image_name": "11513.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 201.59, + 377.04, + 694.379, + 503.958 + ], + "priority": 4, + "parents": [ + 13412 + ], + "children": [], + "area": 76007.4936, + "iscrowd": 0, + "segmentation": [], + "text": "“Ecological Filter” theory suggests that\nenvironmental filters influence the outcome\nof ecological restoration and ultimately\nlong-term restoration success. In this study,\nthree types of environmental filters:\ndispersal, biotic and abiotic, were\nmanipulated to improve understanding of\nhow to successfully re-establish native plant\ncommunities. The filters were manipulated\nwith use of transferred topsoil salvaged\nfrom under native Banksia Woodland." + }, + { + "id": 13416, + "strid": "e96b85ea-63b8-45f9-be19-dafd4fcc1b2b", + "image_id": 201037, + "image_name": "11513.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 931.025, + 273.218, + 807.5119999999998, + 609.5409999999999 + ], + "priority": 5, + "parents": [ + 13409 + ], + "children": [], + "area": 254372.78845000002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 13420, + "strid": "7537ccbb-bcb6-404c-8a01-b8e04a8889d5", + "image_id": 201037, + "image_name": "11513.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 176.333, + 900.394, + 1625.576, + 2103.852 + ], + "priority": 6, + "parents": [ + 13409 + ], + "children": [], + "area": 158769.175202, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 13414, + "strid": "464ad4e4-aa87-4eaf-8ee0-27fb85974901", + "image_id": 201037, + "image_name": "11513.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 396.267, + 3096.287, + 1295.652, + 701.134 + ], + "priority": 7, + "parents": [ + 13409 + ], + "children": [], + "area": 1226956.360629, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 13423, + "strid": "43a888cd-2a00-42b3-8bf9-2edc6c8653f4", + "image_id": 201037, + "image_name": "11513.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 219.326, + 4263.003, + 498.48799999999994, + 58.61800000000039 + ], + "priority": 8, + "parents": [ + 13409 + ], + "children": [ + 13418 + ], + "area": 934987.3959779999, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgments" + }, + { + "id": 13418, + "strid": "2c64bd9b-131f-4010-8224-84d2541cc720", + "image_id": 201037, + "image_name": "11513.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 218.098, + 4327.868, + 1619.897, + 114.35800000000017 + ], + "priority": 9, + "parents": [ + 13423 + ], + "children": [], + "area": 943899.3550640001, + "iscrowd": 0, + "segmentation": [], + "text": "Many thanks to great co-workers and volunteers who helped me greatly with very extensive field work and vegetation\ndata: Billi Veber, William Fowler, Mark Brundrett, Anna Wisolith, Karen Taylor, Vanda Longman, Mark Gerlach, Amity\nWilliams, Christina Birnbaum, Niels Brouwers, and Megan Brown." + }, + { + "id": 13417, + "strid": "672ce665-49f4-4185-a259-f1e3205a30b3", + "image_id": 201037, + "image_name": "11513.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2488.565, + 563.615, + 233.58300000000008, + 51.70600000000002 + ], + "priority": 10, + "parents": [ + 13409 + ], + "children": [ + 13422, + 13415 + ], + "area": 1402592.562475, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 13415, + "strid": "6697f8a4-7bc6-4281-a312-516e211df8ed", + "image_id": 201037, + "image_name": "11513.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1810.744, + 622.743, + 970.383, + 1133.087 + ], + "priority": 11, + "parents": [ + 13417 + ], + "children": [], + "area": 1127628.1507920001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 13422, + "strid": "b773ae2e-779c-4a02-aa82-f1bf94ded3f1", + "image_id": 201037, + "image_name": "11513.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2809.124, + 642.08, + 575.7060000000001, + 1019.285 + ], + "priority": 12, + "parents": [ + 13417 + ], + "children": [], + "area": 1803682.33792, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 13421, + "strid": "a623c922-d43a-44fa-9c63-8a14bdba4755", + "image_id": 201037, + "image_name": "11513.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2125.829, + 1808.895, + 983.9919999999997, + 60.728000000000065 + ], + "priority": 13, + "parents": [ + 13409 + ], + "children": [ + 13419, + 13425, + 13424 + ], + "area": 3845401.4489550004, + "iscrowd": 0, + "segmentation": [], + "text": "Results (first year after topsoil transfer)" + }, + { + "id": 13419, + "strid": "e91cf2dd-62c8-4600-ab16-42aaa4c51aea", + "image_id": 201037, + "image_name": "11513.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1820.743, + 1870.302, + 1604.509, + 1117.8749999999998 + ], + "priority": 14, + "parents": [ + 13421 + ], + "children": [], + "area": 3405339.274386, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 13424, + "strid": "28768922-dcc5-4828-ae96-bc5414376e3b", + "image_id": 201037, + "image_name": "11513.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1893.897, + 3078.88, + 1320.5429999999997, + 584.5720000000001 + ], + "priority": 15, + "parents": [ + 13421 + ], + "children": [], + "area": 5831081.59536, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 13425, + "strid": "8c82b0cd-6a2c-415a-ad10-0e0616064c4b", + "image_id": 201037, + "image_name": "11513.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1895.656, + 3734.508, + 1370.114, + 726.4480000000003 + ], + "priority": 16, + "parents": [ + 13421 + ], + "children": [], + "area": 7079342.4972479995, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 41116, + "strid": "6c0440a3-7822-4d2a-a688-283c90b5087d", + "image_id": 202115, + "image_name": "118165.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 625.9, + 361.84, + 243.26, + 170.28000000000003 + ], + "priority": -1, + "parents": [], + "children": [ + 41102, + 41099, + 41114, + 41109, + 41107, + 41106, + 41108, + 41111, + 41104, + 41103, + 41105, + 41098, + 41101, + 41110, + 41100 + ], + "area": 226475.656, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 41098, + "strid": "1a4f38cb-0eec-439f-b06a-9896368fd725", + "image_id": 202115, + "image_name": "118165.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 109.477, + 100.312, + 5378.191, + 251.99199999999996 + ], + "priority": 1, + "parents": [ + 41116 + ], + "children": [], + "area": 10981.856824, + "iscrowd": 0, + "segmentation": [], + "text": "Abiotic factors affecting sapflow rates and chlorophyi! fluorescence in Juniperus virginiaiia, Lonicereé\nmaackil, and Pyrus calleryana on a roadcut in Kentucky he" + }, + { + "id": 41099, + "strid": "a173203e-eceb-4309-b449-e8069b42082e", + "image_id": 202115, + "image_name": "118165.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1120.141, + 378.293, + 3358.8839999999996, + 170.764 + ], + "priority": 2, + "parents": [ + 41116 + ], + "children": [], + "area": 423741.499313, + "iscrowd": 0, + "segmentation": [], + "text": "— Richard L. Boyce\northern Kentucky University, Highland Heights, KY 41099" + }, + { + "id": 41109, + "strid": "06220394-0a23-497d-8a48-1140b64a77bd", + "image_id": 202115, + "image_name": "118165.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 146.195, + 562.891, + 270.53, + 28.730000000000018 + ], + "priority": 3, + "parents": [ + 41116 + ], + "children": [ + 41112 + ], + "area": 82291.84974499998, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 41112, + "strid": "7ac4a0f3-301b-4d2f-a4ff-55a3d782d901", + "image_id": 202115, + "image_name": "118165.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 144.418, + 642.397, + 885.6830000000001, + 1116.7510000000002 + ], + "priority": 4, + "parents": [ + 41109 + ], + "children": [], + "area": 92773.68994600001, + "iscrowd": 0, + "segmentation": [], + "text": "Transpiration is controlled both by vapor pressure deficit (VPD),\nwhich sets the maximum rate at which water can leave the plant,\nand soil water content (volumetric water content, or VWC),\nwhich controls how fast water can be replaced. These parameters\nmay be used to assess and model transpiration from plants.\nHowever, processes that control transpiration work on many\nspatial and temporal scales with multiple time lags; they also\nexhibit serial dependence, which means that the assumptions of\nconventional parametric analyses are violated.\n\nARMA (autoregressive moving average) models are appropriate\nin this case. ARMA models used on short time scales (1 minute to\n1 hour) have shown that woody plant transpiration is driven by\nVPD (e.g., Ford et al. 2005), but it is unclear how this scales up\nto time steps of a day.\n\nI have been examining the woody community on a road cut in\nnorthern Kentucky, which is dominated by three species: the\nsmall native evergreen tree, red cedar (Juniperus virginiana L.),\nthe long-term invasive deciduous shrub, Amur honeysuckle\n(Lonicera maackii (Rupr.) Maxim), and thesmall emerging\ninvasive deciduous tree Callery pear (Pyrus calleryana Decne.).\nAll three species are commonly found in these sites, which are\ncharacterized by steep slopes, thinsoils, and frequent droughts.\n\nThe purpose of this study was to discover which\nenvironmental factors control water use and photosynthetic\npotential in species with quite different characteristics." + }, + { + "id": 41110, + "strid": "56058fe2-c5e3-4de7-958d-640c836545d6", + "image_id": 202115, + "image_name": "118165.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 145.931, + 1891.609, + 173.86799999999997, + 26.835000000000036 + ], + "priority": 5, + "parents": [ + 41116 + ], + "children": [ + 41113 + ], + "area": 276044.392979, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 41113, + "strid": "71f959c0-a8df-4243-9208-4647fd20113c", + "image_id": 202115, + "image_name": "118165.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 144.213, + 1970.257, + 892.8220000000001, + 1356.145 + ], + "priority": 6, + "parents": [ + 41110 + ], + "children": [], + "area": 284136.672741, + "iscrowd": 0, + "segmentation": [], + "text": "The study was carried out at on a northwest-facing road cut on I-\n275 in Highland Heights, KY (39° 2°22” N, 84° 28’6” W), on\nthe edge of the Northern Kentucky University campus (Castellano\nand Boyce 2007). I monitored 4 individuals of each of the three\nstudy species. Granier sap flow probes, constructed in the lab\nfrom 18-gauge 7.5 cm-long syringe needs and thermocouple wire,\nwere inserted near the base of each plant and used to measure\nsapflow velocities as an estimate of transpiration. Measurements\nwere taken every minute and averaged every hour by a data\nlogger, and data were downloaded periodically and analyzed in\nthe lab. VPD was determined from temperature and relative\nhumidity measurements, and soil volumetric water content\n(VWC) in the top 30 cm was measured with time domain\nreflectometry (TDR) probes. Light measurements were collected\nwith a a Li-Cor quantum sensor. On an approximately weekly\nbasis, chlorophyll fluorescence measurements were collected\nfrom the plants with sap flow probes. Both light (®).); a measure\nof photosynthetic capacity) and dark (F',/F,,,; a measure of stress)\nfluorescence were measured, with two measurements per plant.\nPlant measurements were then averaged, and species mean + 1\nSD were determined. Fluorescence data from the two years were\nfitted separately with linear regression to the following\nenvironmental parameters: temperature, light, time of day, sum of\ndaylight VPD, and VWC.\n\nTransfer-function ARMA models, using VPD and VWC as\nindependent variables, were fitted to the sapflow data for each\nspecies. For J. virginiana, one data set from early March 2012\nthrough late July 2013 was used. For L. maackii and P.\ncalleryana, data sets from 2012 and 2013 were run separately.\nModels were selected and fitted using the procedures outlined in\nCryer and Chan (2008), which were also used to select and treat\noutliers. All analyses were performed in R (R Development Core\nTeam 2013) using the package TSA." + }, + { + "id": 41104, + "strid": "83ccede5-d41b-43ed-9646-8559a4072bc5", + "image_id": 202115, + "image_name": "118165.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1148.084, + 583.96, + 860.204, + 120.46900000000005 + ], + "priority": 7, + "parents": [ + 41116 + ], + "children": [], + "area": 670435.1326400001, + "iscrowd": 0, + "segmentation": [], + "text": "Temperature, VPD; and VWC: Factors\nthat Could Drive Transpiration" + }, + { + "id": 41100, + "strid": "74d23a95-ce44-4906-94a9-24d2e15cfd02", + "image_id": 202115, + "image_name": "118165.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1161.0, + 741.334, + 668.0059999999999, + 1024.978 + ], + "priority": 8, + "parents": [ + 41116 + ], + "children": [], + "area": 860688.774, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 41105, + "strid": "fb14f266-a01c-4e07-9223-b06f46c3d6d9", + "image_id": 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"parents": [ + 41116 + ], + "children": [ + 41115 + ], + "area": 2881162.9263119996, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 41115, + "strid": "3e776fb3-203b-42b9-b496-b14a18b04e81", + "image_id": 202115, + "image_name": "118165.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 4034.877, + 792.619, + 1457.368, + 2610.747 + ], + "priority": 17, + "parents": [ + 41111 + ], + "children": [], + "area": 3198120.172863, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 41114, + "strid": "9a50e7cc-c9d0-402f-b388-d872f8289962", + "image_id": 202115, + "image_name": "118165.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 105.459, + 3371.611, + 878.1469999999999, + 105.74699999999984 + ], + "priority": 18, + "parents": [ + 41116 + ], + "children": [], + "area": 355566.724449, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgments\nNKU Center for Integrative Natural Sciences & Mathematics (funding)\nRachael Delaney (field work)" + }, + { + "id": 105669, + "strid": "820f172d-e099-4388-9576-117702ec283d", + "image_id": 204587, + "image_name": "12449.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 334.05, + 110.63, + 127.07, + 113.45000000000002 + ], + "priority": -1, + "parents": [], + "children": [ + 105659, + 105662, + 105651, + 105649, + 105650, + 105660, + 105657, + 105661, + 105652, + 105648, + 105658 + ], + "area": 36955.9515, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 105648, + "strid": "c387d2e6-9472-4447-9789-394592dac78d", + "image_id": 204587, + "image_name": "12449.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 552.135, + 25.803, + 2283.398, + 189.383 + ], + "priority": 1, + "parents": [ + 105669 + ], + "children": [], + "area": 14246.739405, + "iscrowd": 0, + "segmentation": [], + "text": "intratumoral Infiltration of CD8+/Ki-67+ Lymphocytes is Stronger in\nHigher Grade Penile Squamous Cell Carcinomas" + }, + { + "id": 105649, + "strid": "cb4edd0a-f1e5-446e-9f74-7a28c04862dd", + "image_id": 204587, + "image_name": "12449.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 576.328, + 221.944, + 2243.671, + 262.871 + ], + "priority": 2, + "parents": [ + 105669 + ], + "children": [], + "area": 127912.541632, + "iscrowd": 0, + "segmentation": [], + "text": "Margaret Cocks'; Diana Taheri?; Mark Ball'; Stephania M. Bezerra®; Maria Del Carmen Rodriguez Pefia*;\nTrinity J Bivalacqua’; Rajni Sharma’; Alan Meeker\"; Ilse J. Lopez®; Alcides Chaux*®;\nArthur L. Burnett’; and George J. Netto, MD*\n\n‘Johns Hopkins University, Baltimore, MD; 2Tehran University of Medical Sciences; °A.C. Camargo Cancer Center, Sao Paulo;\n“University of Alabama at Birmingham, Birmingham, AL; 5Norte University, Asuncion; °Centro para el Desarrollo de la Investigacién Cientifica, Asuncion" + }, + { + "id": 105657, + "strid": "844ff12b-bbe6-45f4-8caa-f6654ce7bea5", + "image_id": 204587, + "image_name": "12449.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 86.989, + 595.428, + 331.092, + 57.504999999999995 + ], + "priority": 3, + "parents": [ + 105669 + ], + "children": [ + 105663 + ], + "area": 51795.686292000006, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 105663, + "strid": "3833fc38-4693-4cc6-b838-86eb3eea446b", + "image_id": 204587, + "image_name": "12449.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 88.788, + 679.111, + 840.283, + 190.75099999999998 + ], + "priority": 4, + "parents": [ + 105657 + ], + "children": [], + "area": 60296.907468, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 105658, + "strid": "4b70e534-ce8b-45d6-8751-820e651b6563", + "image_id": 204587, + "image_name": "12449.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 87.924, + 938.629, + 175.468, + 55.83100000000002 + ], + "priority": 5, + "parents": [ + 105669 + ], + "children": [ + 105664 + ], + "area": 82528.01619600001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 105664, + "strid": "2cde81ba-da7e-44db-b94b-81771bab1b30", + "image_id": 204587, + "image_name": "12449.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 89.333, + 1024.658, + 838.071, + 304.394 + ], + "priority": 6, + "parents": [ + 105658 + ], + "children": [], + "area": 91535.773114, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 105659, + "strid": "bf77b6e1-69e0-4dae-b35a-390e396b321e", + "image_id": 204587, + "image_name": "12449.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 83.857, + 1404.647, + 539.864, + 60.26800000000003 + ], + "priority": 7, + "parents": [ + 105669 + ], + "children": [ + 105665, + 105666 + ], + "area": 117789.48347899999, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 105665, + "strid": "46fd795b-ce65-4525-9737-5201b5503b2a", + "image_id": 204587, + "image_name": "12449.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 84.773, + 1498.26, + 857.63, + 474.29600000000005 + ], + "priority": 8, + "parents": [ + 105659 + ], + "children": [], + "area": 127011.99497999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 105666, + "strid": "a881d0b1-159c-4e2d-ad18-941513988c4d", + "image_id": 204587, + "image_name": "12449.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2465.568, + 591.308, + 854.5059999999999, + 200.67899999999997 + ], + "priority": 9, + "parents": [ + 105659 + ], + "children": [], + "area": 1457910.0829440001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 105650, + "strid": "4e884bf6-b92a-4b40-a514-e689b8874e5f", + "image_id": 204587, + "image_name": "12449.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1040.98, + 574.087, + 645.98, + 485.8890000000001 + ], + "priority": 10, + "parents": [ + 105669 + ], + "children": [ + 105653 + ], + "area": 597613.08526, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 105653, + "strid": "49827ec9-e4c7-4e57-898c-e7c6fbf2cbd1", + "image_id": 204587, + "image_name": "12449.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1090.325, + 1066.884, + 534.9269999999999, + 56.789999999999964 + ], + "priority": 11, + "parents": [ + 105650 + ], + "children": [], + "area": 1163250.2973, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. Immunohistochemistry for CD8 and Ki67 in\nintratumoral lymphocytes" + }, + { + "id": 105651, + "strid": "39cf0602-e8fd-40c9-9333-b9a712a8cd30", + "image_id": 204587, + "image_name": "12449.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1720.059, + 574.025, + 645.903, + 486.01599999999996 + ], + "priority": 12, + "parents": [ + 105669 + ], + "children": [ + 105654 + ], + "area": 987356.867475, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 105654, + "strid": "de9da7ef-92ea-436c-98b7-bd8eca04e348", + "image_id": 204587, + "image_name": "12449.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1753.034, + 1068.892, + 596.7759999999998, + 56.077999999999975 + ], + "priority": 13, + "parents": [ + 105651 + ], + "children": [], + "area": 1873804.018328, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2. Immunohistochemistry for FOXP3 in peritumoral\nlymphocytes" + }, + { + "id": 105652, + "strid": "a33b3729-d149-4ea1-8fd6-fb3a2a62e5b7", + "image_id": 204587, + "image_name": "12449.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 992.682, + 1155.439, + 1400.164, + 260.99299999999994 + ], + "priority": 14, + "parents": [ + 105669 + ], + "children": [ + 105655 + ], + "area": 1146983.4973980002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 105655, + "strid": "9cbc2fee-b90d-4fb7-b6c2-d40ce9ef329c", + "image_id": 204587, + "image_name": "12449.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1122.308, + 1428.381, + 1162.3050000000003, + 32.86699999999996 + ], + "priority": 15, + "parents": [ + 105652 + ], + "children": [], + "area": 1603083.423348, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3. CD8+, CD8+/Ki67+ and FOXP3+ counts of intratumoral and peritumoral lymphocytes by histologic grades" + }, + { + "id": 105662, + "strid": "c02632da-de4e-4e77-a805-5bdadf5d8d43", + "image_id": 204587, + "image_name": "12449.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1010.82, + 1502.712, + 1388.208, + 501.172 + ], + "priority": 16, + "parents": [ + 105669 + ], + "children": [ + 105656 + ], + "area": 1518971.34384, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 105656, + "strid": "a8d58737-f717-4261-ba12-3dcefb029fad", + "image_id": 204587, + "image_name": "12449.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1023.405, + 2014.442, + 1364.631, + 59.248999999999796 + ], + "priority": 17, + "parents": [ + 105662 + ], + "children": [], + "area": 2061590.01501, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1. Odds ratios (OR) and 95% confidence intervals (Cl) for high-grade tumors by CD8+, Ki67+ and FOXP3 positivity in intratumoral\nlymphocytes and peritumoral lymphocytes considering unadjusted and adjusted models" + }, + { + "id": 105661, + "strid": "5b4bd4a8-cbc2-40cc-b188-48f6ed26c3ab", + "image_id": 204587, + "image_name": "12449.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2466.425, + 856.044, + 457.1260000000002, + 57.24400000000003 + ], + "priority": 18, + "parents": [ + 105669 + ], + "children": [ + 105667 + ], + "area": 2111368.3227, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 105667, + "strid": "515959c9-07e3-4d5b-b59f-f7fd7e7fdf53", + "image_id": 204587, + "image_name": "12449.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2468.805, + 939.26, + 846.4140000000002, + 511.4089999999999 + ], + "priority": 19, + "parents": [ + 105661 + ], + "children": [], + "area": 2318849.7843, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 105660, + "strid": "bd287967-f4f9-40b8-b5ed-ced0083761d4", + "image_id": 204587, + "image_name": "12449.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2464.24, + 1521.178, + 346.10300000000007, + 59.269000000000005 + ], + "priority": 20, + "parents": [ + 105669 + ], + "children": [ + 105668 + ], + "area": 3748547.67472, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 105668, + "strid": "6befa81d-dd14-48be-8cdd-86259bcba6de", + "image_id": 204587, + "image_name": "12449.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2470.795, + 1604.041, + 797.5540000000001, + 313.6009999999999 + ], + "priority": 21, + "parents": [ + 105660 + ], + "children": [], + "area": 3963256.482595, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 72574, + "strid": "5df9b29b-47d0-49b7-aa3d-f5ae9724f0ed", + "image_id": 203329, + "image_name": "120058.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 562.13, + 83.73, + 241.37, + 214.56 + ], + "priority": -1, + "parents": [], + "children": [ + 72556, + 72554, + 72553, + 72552, + 72551, + 72555 + ], + "area": 47067.1449, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 72551, + "strid": "ee791929-8f1e-46aa-b208-d408e39bf182", + "image_id": 203329, + "image_name": "120058.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 898.976, + 68.445, + 1588.79, + 248.526 + ], + "priority": 1, + "parents": [ + 72574 + ], + "children": [], + "area": 61530.412319999996, + "iscrowd": 0, + "segmentation": [], + "text": "Impact of DWI denoising on\nTrack-Density Imaging" + }, + { + "id": 72552, + "strid": "0a68f7a7-a380-4525-a67f-45443772086a", + "image_id": 203329, + "image_name": "120058.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 395.14, + 370.693, + 2481.42, + 311.41100000000006 + ], + "priority": 2, + "parents": [ + 72574 + ], + "children": [], + "area": 146475.63202, + "iscrowd": 0, + "segmentation": [], + "text": "Pierrick Coupé’, Olivier Periot2>; José V. Manjon?, Bassem_Hiba*, Michéle Allard25\n\n1 Laboratoire Bordelais de Recherche en Informatique, Unité Mixte de Recherche CNRS (UMR 5800), PICTURA Research Group, Université de Bordeaux, France\n2 Unive Bordeaux, INCIA, UMR 5287, F-33400 Talence, France.\nCNRS, INCIA, UMR 5287, F-33400 Talence, France.\n3 Instituto de Aplicaciones de las Tecnologias de la-Informaciéon y de las Comunicaciones Avanzadas (ITACA), Universitat Politécnica de Valéncia, Valencia, Spain\n4 Centre de Résonance Magnétique des Systemes Biologiques, UMR 5536 CNRS, Université Bordeaux Segalen, F-33076 Bordeaux, France\n5 CHU de Bordeaux, F-33076 Bordeaux, France" + }, + { + "id": 72553, + "strid": "f7c6a35e-1b7a-4065-96f1-ef3626e2618e", + "image_id": 203329, + "image_name": "120058.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 68.834, + 762.47, + 378.352, + 56.09400000000005 + ], + "priority": 3, + "parents": [ + 72574 + ], + "children": [ + 72557 + ], + "area": 52483.85998, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 72557, + "strid": "144a2775-b503-4814-bfc8-5890696ff24b", + "image_id": 203329, + "image_name": "120058.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 58.253, + 846.962, + 1554.41, + 315.38099999999986 + ], + "priority": 4, + "parents": [ + 72553 + ], + "children": [], + "area": 49338.077386, + "iscrowd": 0, + "segmentation": [], + "text": "TYrack-Density Imaging (TDI) [1] has beén proposed as super-resolution\nmethod for diffusion-weighted images (BWI). Based on fiber-tracking (FT), TDI\nenables to produce high-resolution white matter images. However, the\nsensitivity to noise of FT negatively impacts TDI accuracy and reproducibility\n[3]. In this study, we analyzed ‘whether the use of DWI denoising is able-to\nimprove TDI robustness and_reproducibility." + }, + { + "id": 72555, + "strid": "cf8de4da-2719-4b2c-9364-8f85a095c320", + "image_id": 203329, + "image_name": "120058.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 62.0, + 1265.997, + 266.631, + 54.9670000000001 + ], + "priority": 5, + "parents": [ + 72574 + ], + "children": [ + 72566, + 72563, + 72564, + 72565, + 72562, + 72569 + ], + "area": 78491.814, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 72562, + "strid": "ca4296b7-30f1-4c36-8104-f6e9d248bda9", + "image_id": 203329, + "image_name": "120058.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 57.848, + 1350.797, + 1554.687, + 314.8899999999999 + ], + "priority": 6, + "parents": [ + 72555 + ], + "children": [], + "area": 78140.904856, + "iscrowd": 0, + "segmentation": [], + "text": "Data: 10 DWI acquisitions of a human brain were acquired using a 3T MR\nscanner (Achieva, Philips Medical Systems). A standard spin-echo EPI pulse\nsequencexwith sensitivity encoding was used (b-value: 700 s/mm2; 21\ndiffusion-directions) with the following parameters:-TEAR ~ 60/8000 ms; FOV\n= 215x215x85 mm%; matrix size = 172x172 with.68 slices and an isotropic\nspatial resolution of 1.2x1.2x1.2 mm?." + }, + { + "id": 72563, + "strid": "4b0ce56b-fa2e-4359-98af-869f2f6e648c", + "image_id": 203329, + "image_name": "120058.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 58.201, + 1696.827, + 1556.474, + 367.7299999999998 + ], + "priority": 7, + "parents": [ + 72555 + ], + "children": [], + "area": 98757.028227, + "iscrowd": 0, + "segmentation": [], + "text": "Image Processing: To compensate for. inter-acquisition motion and intra-\nacquisition eddy current distortion, all the DWI (i.e., 220 images) were linearly\nregistered to the bO image of the first ‘acquisition. As shown in [2], trilinear\ninterpolation of FSL eddy current ‘correction [6] tends to overblur the corrected\nimages. Therefore, the FSL script was modified to use nearest neighbor\ninterpolation to better preserve) structures and noise patterns. Finally, the b-\nmatrixes of the 10 acquisitions were adjusted to account for head rotation." + }, + { + "id": 72564, + "strid": "0d306323-b962-48fc-8c1e-13f57475ee64", + "image_id": 203329, + "image_name": "120058.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 58.32, + 2096.657, + 1553.285, + 262.60699999999997 + ], + "priority": 8, + "parents": [ + 72555 + ], + "children": [], + "area": 122277.03624000002, + "iscrowd": 0, + "segmentation": [], + "text": "Noisy and Denoised.testing datasets: To investigate the impactsof denoising\non TDI, two testing’ datasets were used. First, the noisy»dataset was\ncomposed of the~10 motion-corrected original acquisitions. Second, the\ndenoised dataset was based on the same 10 acquisitions but denoised using\nthe LPCA denoising filter (http:/www.nitrc.org/projects/dti-dendising/) [4] (see Fig. 1)." + }, + { + "id": 72565, + "strid": "996aed93-9204-4430-98e4-95a995fa4c0c", + "image_id": 203329, + "image_name": "120058.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 60.4, + 2388.508, + 1551.688, + 156.587 + ], + "priority": 9, + "parents": [ + 72555 + ], + "children": [], + "area": 144265.88319999998, + "iscrowd": 0, + "segmentation": [], + "text": "Gold-Standard (GS): The 10 acquisitions of the noisy dataset were averaged\nin orderto estimate the GS. This resulted in a high\\SNR GS used as reference\nduring experiments (see Fig. 1)." + }, + { + "id": 72566, + "strid": "e6eee910-d8de-4e98-b6e9-c5fca84f2aaf", + "image_id": 203329, + "image_name": "120058.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 58.905, + 2576.802, + 1552.751, + 367.79800000000023 + ], + "priority": 10, + "parents": [ + 72555 + ], + "children": [], + "area": 151786.52181, + "iscrowd": 0, + "segmentation": [], + "text": "TDI: TDI [1] was estimated from the GS,:the noisy and the denoised datasets.\nThe diffusion tensors and FA maps were obtained by using FSL. Whole brain\ntractography was obtained with MRtrix [7] by using constrained spherical\ndeconvolution [5] and probabilistic streamlines tractography. The default\ntracking parameters were uSed (seed = whole brain, step-size = 0.2¢mm,\nmaximum harmonics order.=(6, 10 000 000 tracks). Finally, a super-resolution\nTDI map was created at 0.3’mm isotropic resolution." + }, + { + "id": 72569, + "strid": "806c3992-3eb8-46a8-b1ef-a14d359cf95a", + "image_id": 203329, + "image_name": "120058.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 48.983, + 3003.137, + 1576.923, + 688.0250000000001 + ], + "priority": 11, + "parents": [ + 72555 + ], + "children": [ + 72573 + ], + "area": 147102.659671, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 72573, + "strid": "c36aa62b-60ed-447a-9832-3b0743b4af26", + "image_id": 203329, + "image_name": "120058.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 146.829, + 3704.739, + 1365.741, + 42.014000000000124 + ], + "priority": 12, + "parents": [ + 72569 + ], + "children": [], + "area": 543963.122631, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1: The gold Standard>(left), noisy (middle) and denoised (right) datasets" + }, + { + "id": 72554, + "strid": "70e36960-76cb-4439-89b2-063209578bc3", + "image_id": 203329, + "image_name": "120058.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1713.879, + 760.518, + 237.0, + 55.855999999999995 + ], + "priority": 13, + "parents": [ + 72574 + ], + "children": [ + 72570, + 72559, + 72560, + 72561, + 72558, + 72568 + ], + "area": 1303435.829322, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 72558, + "strid": "5df8bef7-6e2f-44bd-8ed8-9a296bcc8df7", + "image_id": 203329, + "image_name": "120058.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1712.655, + 847.034, + 1542.329, + 448.0279999999999 + ], + "priority": 14, + "parents": [ + 72554 + ], + "children": [], + "area": 1450677.0152699999, + "iscrowd": 0, + "segmentation": [], + "text": "ToNinvestigate the impact of LPCA denoising,on TDI, PSNR was estimated\nbetween TDI of both testing datasets and TDI of the GS. This quality metrics\nwas computed over a mask where TDI.of the GS was higher than 0. Higher\nvalues of PSNR indicate higher similarity compared to GS. The average\nPSNR was 24.14dB (+/- 0.28) forthe noisy dataset and 27.30dB (+/- 0.14) for\nthe denoised dataset.\n\nFigure 2 shows TDI maps,calculated from GS, noisy and denoised datasets.\nThe structures are visually. more distinct and less noisy in the denoised TDI" + }, + { + "id": 72559, + "strid": "6bd9acff-9fae-42aa-92d7-98f0a991511a", + "image_id": 203329, + "image_name": "120058.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1716.743, + 1308.612, + 99.43299999999999, + 38.534000000000106 + ], + "priority": 15, + "parents": [ + 72554 + ], + "children": [], + "area": 2246550.490716, + "iscrowd": 0, + "segmentation": [], + "text": "map." + }, + { + "id": 72568, + "strid": "1d903c26-c1b6-4dd9-83d6-010dfcc8da1c", + "image_id": 203329, + "image_name": "120058.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2009.723, + 1313.756, + 989.7889999999998, + 988.7949999999998 + ], + "priority": 16, + "parents": [ + 72554 + ], + "children": [ + 72567 + ], + "area": 2640285.649588, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 72567, + "strid": "12184734-abe5-4da2-9010-d60ee4b8045e", + "image_id": 203329, + "image_name": "120058.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1716.574, + 2319.809, + 1531.7779999999998, + 43.6840000000002 + ], + "priority": 17, + "parents": [ + 72568 + ], + "children": [], + "area": 3982123.8143660007, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2 : RGBxfDI maps estimated from noisy, denoised and the gold standard datasets" + }, + { + "id": 72560, + "strid": "53b35581-64cf-47eb-939a-51486c31be32", + "image_id": 203329, + "image_name": "120058.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1714.329, + 2419.249, + 1538.2769999999998, + 209.433 + ], + "priority": 18, + "parents": [ + 72554 + ], + "children": [], + "area": 4147388.7189209997, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3\\shows the maps of coefficient of variation (CoV)=100*o/\" and of\ncoefficient of dispersion (CoD)=02/u estimatedyoVer the 10 acquisitions for\nboth, datasets. CoV and CoD maps of the noisy dataset demonstrate a more\npronounced speckled appearance with high-values in GM and at the level of" + }, + { + "id": 72561, + "strid": "c517159a-3507-4b83-82f4-5e31528727c7", + "image_id": 203329, + "image_name": "120058.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1713.482, + 2633.596, + 278.22, + 40.15299999999979 + ], + "priority": 19, + "parents": [ + 72554 + ], + "children": [], + "area": 4512619.341272, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 72570, + "strid": "03c0d732-90fc-41fc-b2db-e99672ef3fa8", + "image_id": 203329, + "image_name": "120058.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2004.844, + 2664.926, + 992.6089999999999, + 1044.35 + ], + "priority": 20, + "parents": [ + 72554 + ], + "children": [ + 72572 + ], + "area": 5342760.901544, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 72572, + "strid": "5642d27e-4cdf-4e6f-b906-520d0eb776ea", + "image_id": 203329, + "image_name": "120058.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1844.021, + 3720.784, + 1284.2499999999998, + 42.623999999999796 + ], + "priority": 21, + "parents": [ + 72570 + ], + "children": [], + "area": 6861203.832464, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3: CoV and CoD maps computed over noisy and denoised datasets" + }, + { + "id": 72556, + "strid": "548d6427-98d1-4009-a707-11bba887d05c", + "image_id": 203329, + "image_name": "120058.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 65.906, + 3847.577, + 434.588, + 64.4699999999998 + ], + "priority": 22, + "parents": [ + 72574 + ], + "children": [ + 72571 + ], + "area": 253578.40976200002, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 72571, + "strid": "6ae03e03-0b4c-4b82-8d15-0586f996e7e0", + "image_id": 203329, + "image_name": "120058.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 59.692, + 3941.702, + 3190.294, + 262.576 + ], + "priority": 23, + "parents": [ + 72556 + ], + "children": [], + "area": 235288.07578400002, + "iscrowd": 0, + "segmentation": [], + "text": "The gain of 3dB in term of PSNR demonstrates the higher’similarity between TDI of denoised acquisitions and TDI of the GS. Moreover, theclower standard\ndeviation of.this metric highlights the better consistency ‘of TDI estimation after denoising. Visual ‘assessment of RGB TDI maps demonstrates~a better contrast\nand conspicuity of boundaries between GM, WM and)ventricles on the denoised images. Moreover, in CoV and CoD maps, high values-indicate regions where\nTDI measurements are the less consistent oversthe’10 acquisitions. By using LPCA filter, it)appears that TDI reproducibility is globally improved. Finally,\nDWhk denoising enables to limit false positive. FDI values in GM and CSF." + }, + { + "id": 67454, + "strid": "cb814669-2589-46e2-9ffe-4658b5609cbd", + "image_id": 203144, + "image_name": "119776.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 28.85, + 67.75, + 139.71, + 131.95 + ], + "priority": -1, + "parents": [], + "children": [ + 67427, + 67428, + 67422, + 67420, + 67423, + 67425, + 67421, + 67424, + 67435, + 67426 + ], + "area": 1954.5875, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 67420, + "strid": "25601d8f-3590-4b9d-b371-7ad1d44dd2e4", + "image_id": 203144, + "image_name": "119776.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 591.121, + 124.292, + 3384.954, + 55.24799999999999 + ], + "priority": 1, + "parents": [ + 67454 + ], + "children": [], + "area": 73471.611332, + "iscrowd": 0, + "segmentation": [], + "text": "COGNITION AND FUNCTIONAL CAPACITY-IN SCHIZOPHRENIA ANB CONTROL SUBJECTS" + }, + { + "id": 67421, + "strid": "defa5abf-e6aa-4938-9979-5732694d01ae", + "image_id": 203144, + "image_name": "119776.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 204.851, + 276.822, + 3773.892, + 184.36699999999996 + ], + "priority": 2, + "parents": [ + 67454 + ], + "children": [], + "area": 56707.263522, + "iscrowd": 0, + "segmentation": [], + "text": "w\n1 Professor and Head, Department of Psychiatry & San Services, PGIMER- Dr. Ram Manohar Lohia reso pvbin India ,2 Indo- US Project, Department of Pact SOO Fan Manohar Lohia Hospital, New Delhi, India,° siteGnn of\nledici ex\n\nSchizophrenia and Related Disorders, School of M ne (Psychiatry), UT Health Sciences Centre, San Antonio, Te 4Professor, Departments of Psychiatry and Human Genetics”, ersity of Pittsburgh, P.A., USA f°’\n\nCS eres N. Deshpande’, Sreelatha S. NOIR Triptish Bhatia*, Dawn |. Velligan?, Vishwajit L. Nirmgaonkar *" + }, + { + "id": 67422, + "strid": "8af1f645-ecae-4477-a9f6-b1296e09782b", + "image_id": 203144, + "image_name": "119776.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 208.397, + 541.655, + 208.051, + 36.72199999999998 + ], + "priority": 3, + "parents": [ + 67454 + ], + "children": [ + 67430, + 67432, + 67431, + 67429 + ], + "area": 112879.27703499999, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 67429, + "strid": "f33943d9-6f5c-418f-a1c8-ac3da84f3e68", + "image_id": 203144, + "image_name": "119776.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 209.101, + 604.808, + 3834.15, + 109.60199999999998 + ], + "priority": 4, + "parents": [ + 67422 + ], + "children": [], + "area": 126465.957608, + "iscrowd": 0, + "segmentation": [], + "text": "Background: The MATRICS Consensus Cognitive Battery (MCCB) was developed as a collaborative effort by the FDA, academic researchers, and pharmaceuticalstoJassess different domains of cognitive functioning in schizophrenia. Cognitive functions\nare a distinct symptom categoryofschizophrenia. However neurocognitive tests alone may not/be correlated to ‘real world’ social behavior which depends on, ‘functional capacity’ measured by a different set of tests. The present study describes\nneurocognition and functional capacity among schizophrenia patients and healthy controls in’New Delhi as part of the Cross-cultural Adaptability of Intermediate Measures Study(CIMS) (Velligan et al 2013)." + }, + { + "id": 67430, + "strid": "d5481e39-3a63-4fd4-adf4-9b076518384b", + "image_id": 203144, + "image_name": "119776.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 209.513, + 739.713, + 3793.505, + 71.56999999999994 + ], + "priority": 5, + "parents": [ + 67422 + ], + "children": [], + "area": 154979.489769, + "iscrowd": 0, + "segmentation": [], + "text": "Methods: Outpatients affecte@with schizophrenia (DSM IV), and controls fulfilling speciftedwn¢clusion criteria, were enrolled after written informed consent.~he MATRICS Consensus Cognitive Battery (MCCB), Fugctional Assessment Battery (FAB) and\nUniversity of California Sa€f.Diego Performance Based Skill Assessment (UPSA-B).were“administered to both groups. Controls without psychiatric illmess, were enrolled from friends of patients or communities." + }, + { + "id": 67431, + "strid": "bb7f5f28-4c8a-42fb-b444-48c74fea864b", + "image_id": 203144, + "image_name": "119776.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 208.154, + 836.74, + 3853.349, + 185.68899999999996 + ], + "priority": 6, + "parents": [ + 67422 + ], + "children": [], + "area": 174170.77796, + "iscrowd": 0, + "segmentation": [], + "text": "Results: 51 schizophrenia patients and 30 controls were assessed. Cognitive (MG@B) and functional capacity (FAB and UPSA-B) were comparegusing Mann Whitney U test. Significant differences between cases and controls on education adjusted scores\non verbal learning andyreasoning (p<0.001) and problem solving (p=0.001) werepresent. Significant gender differences with males performing‘etter in social cognition than females in both case (F (1,49) 5!704 p 0.021) and controls (F (1,28) 8.001, p 0.009)\nwere observed, Ageydifferences observed in controls with the older group (>85yrs)performing better in reasoning and problem solving (F (1,28) 6.803, p 0.014) than the younger age group (20-35yrs). On logistic regression FAB (organization and planning)\nwas associated with group status, speed of processing, verbal learning and\\easoning and problem solving. FAB work and productivity wéré associated with verbal learning. Skills associated with financial management like counting and converting into\nchange was assOciated with group only while skills like identifying important details associated with the payment of bills was associated.with group, attention, reasoning and problem solving and sacial cognition." + }, + { + "id": 67432, + "strid": "6dcfe160-4072-45de-a08e-d803d5e98498", + "image_id": 203144, + "image_name": "119776.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 207.547, + 1048.643, + 3844.947, + 71.63200000000006 + ], + "priority": 7, + "parents": [ + 67422 + ], + "children": [], + "area": 217642.708721, + "iscrowd": 0, + "segmentation": [], + "text": "Contributions of the research: Results confirm that schizophrenia patients perform worse than controls on cognitive tests. FunctioningJs specifically affected by cognitive domains of attention and problem solving. Functional capacity is also impaired on\nvarioUs tests measuring social cognition. These findings have significant implications for treatment." + }, + { + "id": 67423, + "strid": "6c2c7fe9-0a2a-424a-a31f-d025a978fd41", + "image_id": 203144, + "image_name": "119776.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 210.365, + 1187.94, + 296.745, + 30.460000000000036 + ], + "priority": 8, + "parents": [ + 67454 + ], + "children": [ + 67433 + ], + "area": 249900.99810000003, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 67433, + "strid": "cbd3e31e-812f-44ba-8e57-92c3a542306e", + "image_id": 203144, + "image_name": "119776.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 211.871, + 1249.81, + 1877.431, + 509.9100000000001 + ], + "priority": 9, + "parents": [ + 67423 + ], + "children": [], + "area": 264798.49451, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 67424, + "strid": "da4caca0-b85f-45a7-b6e7-7596838829a1", + "image_id": 203144, + "image_name": "119776.png", + "category_id": 5, + "category_name": 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Funded in part by grants from the National ‘institute of Health, USA\n(Training Program foreRsychiatric Genetics in India, D43 TW06167; The impact of yoga supplementation\non cognitive function,among patients with SZ RO1TW008289) and University of Texas , USA." + }, + { + "id": 75519, + "strid": "74ebe598-57e4-4e65-85c1-d52d9291dfa1", + "image_id": 203444, + "image_name": "120242.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 50.37, + 61.39, + 157.24, + 147.70999999999998 + ], + "priority": -1, + "parents": [], + "children": [ + 75514, + 75506, + 75516, + 75518, + 75497, + 75510, + 75494, + 75496, + 75495 + ], + "area": 3092.2143, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 75494, + "strid": "2c36be1c-fcdd-4103-8f23-247da7784eef", + "image_id": 203444, + "image_name": "120242.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 915.473, + 134.992, + 2487.04, + 184.951 + ], + "priority": 1, + "parents": [ + 75519 + ], + "children": [], + "area": 123581.53121599999, + "iscrowd": 0, + "segmentation": [], + "text": "Arabidopsis CHROMOSOME TRANSMISSION FIDELITY:7\n(AtCTF7/ECQO1) is required for meiosis, mitosis and DNA«repair" + }, + { + "id": 75495, + "strid": "46ccfecf-b2fb-40b7-bed3-c9893afc1527", + "image_id": 203444, + "image_name": "120242.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 316.905, + 416.62, + 3677.888, + 174.99799999999993 + ], + "priority": 2, + "parents": [ + 75519 + ], + "children": [], + "area": 132028.9611, + "iscrowd": 0, + "segmentation": [], + "text": "Pablo Bolanos-Villegas'**, Xiaohui.Yang4, Huei-Jing Wang', Chien-TaJuan', Min-Hsiang Chuang', Chris Makaroff* and Guang-Yuh Jauh'?\n\n‘ Molécular and Biological Agricultural Sciences ProgramMaiwan International Graduate Program, Academia Sinica\\Taipei, ? 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[], + "text": "7.Aodel and conclusions" + }, + { + "id": 75513, + "strid": "112ff6c7-bb83-4fd3-b9de-0ba0e4b6fd74", + "image_id": 203444, + "image_name": "120242.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2822.102, + 2360.311, + 965.5639999999999, + 323.99800000000005 + ], + "priority": 24, + "parents": [ + 75514 + ], + "children": [], + "area": 6661038.3937220005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 75512, + "strid": "68324600-5350-4ed1-a20f-6ad418fbe6c2", + "image_id": 203444, + "image_name": "120242.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2733.389, + 2737.023, + 1315.2759999999998, + 480.8539999999998 + ], + "priority": 25, + "parents": [ + 75514 + ], + "children": [], + "area": 7481348.560947001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 197892, + "strid": "77adb85b-3ef0-48d6-8203-651b9d339b99", + "image_id": 208253, + "image_name": "9775.png", + "category_id": 9, + "category_name": "Root", + "bbox": 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Cestarelli+, G. Fiscon’, G. Felici+, P. Bertolazzi?, E. Weitschek?2\n\n‘nstitute of Systems Analysis and Computer Science, National Research Council, Rome, Italy\n3Department of Engineering, Uninettuno International University, Rome, Italy" + }, + { + "id": 197884, + "strid": "e4497707-ae57-4821-bdab-efe9be256dbc", + "image_id": 208253, + "image_name": "9775.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 128.331, + 649.918, + 2494.803, + 401.5189999999999 + ], + "priority": 3, + "parents": [ + 197892 + ], + "children": [], + "area": 83404.62685799999, + "iscrowd": 0, + "segmentation": [], + "text": "Motivations: Next Generation Sequencing (NGS) techniques are rapidly spreading, providing huge amounts of genomic data.\nTherefore, knowledge extraction methods from NGS data are highly requested. In this work, we focus on RNA-seq gene expression\nanalysis and specifically on case-control studies for cancer with rule-based classification algorithms designed to build models, that\ndiscriminate cases from controls.\n\nState of the art algorithms typically extract a single classification model that contains few features (genes). On the other hand, our goal is\nto elicit a higher amount of knowledge by computing more alternative classification models and therefore to discover several features\n\nthat are related to the predicted class." + }, + { + "id": 197885, + "strid": "f9fa52cc-4dea-4e78-bb65-dfc8f8fbadcc", + "image_id": 208253, + "image_name": "9775.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 127.965, + 1147.946, + 2496.746, + 275.47299999999996 + ], + "priority": 4, + "parents": [ + 197892 + ], + "children": [], + "area": 146896.90988999998, + "iscrowd": 0, + "segmentation": [], + "text": "Materials and Methods: we propose CAMUR (Classifier with Alternative and \\ViUltiple Rule-based models), a new method and\nsoftware package able to extract multiple, alternative, and equivalent classification models. CAMUR iteratively computes a rule-based\nclassification model, calculates the power set (or a partial combination) of the features present in the rules, iteratively eliminates those\ncombinations from the data set, and performs again the classification procedure until a stopping criterion is verified. CAMUR includes an\nad-hoc knowledge repository (database) and a complete querying tool." + }, + { + "id": 197886, + "strid": "38db2deb-f995-4ff3-9002-24d9aac7538f", + "image_id": 208253, + "image_name": "9775.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 130.151, + 1545.851, + 685.2239999999999, + 177.14200000000005 + ], + "priority": 5, + "parents": [ + 197892 + ], + "children": [], + "area": 201194.05350100002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 197887, + "strid": "8fe38272-2216-4fff-a95f-2eb19eb19136", + "image_id": 208253, + "image_name": "9775.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 130.151, + 1746.99, + 885.4479999999999, + 524.7099999999998 + ], + "priority": 6, + "parents": [ + 197892 + ], + "children": [], + "area": 227372.49549000003, + "iscrowd": 0, + "segmentation": [], + "text": "In Figure 1, we show how the MSE is composed:\nCAMUR Launcher that iteratively performs the\nclassification procedure, after loading the data\nthrough the Input Manager, and managing it\nwith the Data Elaborator. After that, MSE stores\nthe results into a data base using a module\ncalled Results Elaborator.\n\nThe MSA is a querying too! used for knowledge\nextraction from the data base. A screen shot of\nthe MSA GUI is depicted in Figure 2." + }, + { + "id": 197881, + "strid": "6815e0cd-450b-4f81-86cb-93d5b50df8f2", + "image_id": 208253, + "image_name": "9775.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1157.358, + 1553.557, + 625.163, + 712.423 + ], + "priority": 7, + "parents": [ + 197892 + ], + "children": [ + 197874 + ], + "area": 1798021.622406, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 197874, + "strid": "3d498b6d-0f78-4036-abcd-5f4b95264b78", + "image_id": 208253, + "image_name": "9775.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1221.915, + 2338.822, + 496.576, + 27.16800000000012 + ], + "priority": 8, + "parents": [ + 197881 + ], + "children": [], + "area": 2857841.68413, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. CAMUR MSE Components Scheme" + }, + { + "id": 197880, + "strid": "d2cf3074-b7f6-444a-abd2-02567f2de50c", + "image_id": 208253, + "image_name": "9775.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1956.878, + 1525.975, + 675.1859999999999, + 759.1579999999999 + ], + "priority": 9, + "parents": [ + 197892 + ], + "children": [ + 197875 + ], + "area": 2986146.90605, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 197875, + "strid": "03537f9b-dd47-4b7f-b9ab-d8f1bf58ab5d", + "image_id": 208253, + "image_name": "9775.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2101.866, + 2334.294, + 394.69500000000016, + 27.922999999999774 + ], + "priority": 10, + "parents": [ + 197880 + ], + "children": [], + "area": 4906373.192604, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2. CAMUR MSA Screen Shot" + }, + { + "id": 197888, + "strid": "9f755615-2d9f-4483-90e0-9f5e6a3fcf9f", + "image_id": 208253, + "image_name": "9775.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 127.965, + 2444.418, + 887.635, + 317.01200000000017 + ], + "priority": 11, + "parents": [ + 197892 + ], + "children": [], + "area": 312799.94937000005, + "iscrowd": 0, + "segmentation": [], + "text": "Queries: Through CAMUR MSA, the user can\nset up and execute a query, through which he\ncan extract gene and disease relationships. An\nexample of query is shown in Table 1, where the\npairs of genes that appear most frequently and\ntheir occurrences are depicted." + }, + { + "id": 197879, + "strid": "c8d9bd23-d905-47b4-b397-d04680493b23", + "image_id": 208253, + "image_name": "9775.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1083.84, + 2464.258, + 771.287, + 338.88200000000006 + ], + "priority": 12, + "parents": [ + 197892 + ], + "children": [], + "area": 2670861.3907199996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 197878, + "strid": "5de10a99-1741-4da4-be10-35a28d022664", + "image_id": 208253, + "image_name": "9775.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1989.08, + 2510.337, + 652.5709999999999, + 210.35199999999986 + ], + "priority": 13, + "parents": [ + 197892 + ], + "children": [], + "area": 4993261.11996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 197889, + "strid": "4875ca21-81bc-46a0-aae0-96def15320c7", + "image_id": 208253, + "image_name": "9775.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 121.406, + 2881.676, + 872.3310000000001, + 533.4549999999999 + ], + "priority": 14, + "parents": [ + 197892 + ], + "children": [], + "area": 349852.75645600003, + "iscrowd": 0, + "segmentation": [], + "text": "Results: we downloaded, processed, and\nanalyzed three different RNA-Seq data sets\n(Breast, Head and Neck, and Stomach Cancer,\nTable 2) from The Cancer Genome Atlas\n(TCGA). Our experimental results (Figure 3)\nshow the efficacy of CAMUR: we obtain several\nhigh reliable equivalent classification models,\nfrom which the most frequent genes, their\nrelationships, and the relation with a particular\ncancer are deduced." + }, + { + "id": 197882, + "strid": "ab4c6567-b321-49e9-8a98-edaa50c6eca9", + "image_id": 208253, + "image_name": "9775.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1181.149, + 2881.793, + 577.4470000000001, + 453.7109999999998 + ], + "priority": 15, + "parents": [ + 197892 + ], + "children": [ + 197876 + ], + "area": 3403826.920157, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 197876, + "strid": "f81323b5-2acb-4d21-8fff-005bedf62d70", + "image_id": 208253, + "image_name": "9775.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1108.416, + 3385.316, + 711.251, + 60.96399999999994 + ], + "priority": 16, + "parents": [ + 197882 + ], + "children": [], + "area": 3752338.4194559995, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3. Venn Diagram of the extracted genes for Breast\n(BRCA), Head and Neck (HNSC), and Stomach Cancer (STAD)" + }, + { + "id": 197883, + "strid": "5bd862d2-3da2-42d5-bb29-c0c868ab9524", + "image_id": 208253, + "image_name": "9775.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1860.432, + 2855.423, + 838.5800000000002, + 495.0909999999999 + ], + "priority": 17, + "parents": [ + 197892 + ], + "children": [ + 197877 + ], + "area": 5312320.322736, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 197877, + "strid": "7f782796-20cf-4950-aa5e-81a6be99f438", + "image_id": 208253, + "image_name": "9775.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1904.122, + 3387.516, + 770.3350000000003, + 58.646999999999935 + ], + "priority": 18, + "parents": [ + 197883 + ], + "children": [], + "area": 6450243.740952, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 4. Venn Diagram of the extracted genes by CAMUR ana\ndifferential expression analysis fro the three data sets" + }, + { + "id": 197890, + "strid": "95c48a88-6822-4714-a005-e73da003c055", + "image_id": 208253, + "image_name": "9775.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 121.406, + 3520.073, + 1751.22, + 168.3449999999998 + ], + "priority": 19, + "parents": [ + 197892 + ], + "children": [], + "area": 427357.982638, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions: tn this work, we presented CAMUR a new method for multiple solutions\nextraction in rule-based classification problems. We show that knowledge extraction obtained\nby our algorithm is higher than a standard supervised classification." + }, + { + "id": 197891, + "strid": "e755bc9c-a81a-4a58-ad6f-4a34d4565ce2", + "image_id": 208253, + "image_name": "9775.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 125.778, + 3758.379, + 2501.119, + 111.5010000000002 + ], + "priority": 20, + "parents": [ + 197892 + ], + "children": [], + "area": 472721.393862, + "iscrowd": 0, + "segmentation": [], + "text": "Citation: v. Cestarelli, G. Fiscon, G. Felici, P. Bertolazzi, E. Weitschek: CAMUR: Knowledge extraction from RNA-seq cancer data\nthrough equivalent classification rules. Bioinformatics, 32(5): 697-704, 2016." + }, + { + "id": 62682, + "strid": "1335570f-6ece-481d-8782-3d45bb3032f6", + "image_id": 202970, + "image_name": "119526.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 744.19, + 387.29, + 205.3699999999999, + 128.35999999999996 + ], + "priority": -1, + "parents": [], + "children": [ + 62662, + 62666, + 62675, + 62660, + 62667, + 62659, + 62656, + 62655, + 62661 + ], + "area": 288217.34510000004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 62655, + "strid": "606e1057-c8f6-4788-9e38-2278639054e7", + "image_id": 202970, + "image_name": "119526.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 723.344, + 126.041, + 3878.334, + 145.04900000000004 + ], + "priority": 1, + "parents": [ + 62682 + ], + "children": [], + "area": 91171.00110400001, + "iscrowd": 0, + "segmentation": [], + "text": "Early Impulsivity in Youth at Familial Risk of Bipolar Disorder" + }, + { + "id": 62656, + "strid": "351e2faa-f23d-4b5b-8ecf-b0189131013d", + "image_id": 202970, + "image_name": "119526.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1177.632, + 304.044, + 2750.605, + 281.318 + ], + "priority": 2, + "parents": [ + 62682 + ], + "children": [], + "area": 358051.943808, + "iscrowd": 0, + "segmentation": [], + "text": "Simona Graur, Cecile D. Ladouceur, Anna Manelis, Kelly Monk, Lisa K. Bonar,\n\nGenna M. Bebko, Michele Bertocci, Boris Birmaher, Mary L. Phillips\nDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA" + }, + { + "id": 62660, + "strid": "920621e0-c4cf-4fb2-8c04-0a109a75bec1", + "image_id": 202970, + "image_name": "119526.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 405.047, + 740.826, + 549.581, + 75.51499999999999 + ], + "priority": 3, + "parents": [ + 62682 + ], + "children": [ + 62657 + ], + "area": 300069.348822, + "iscrowd": 0, + "segmentation": [], + "text": "BACKGROUND" + }, + { + "id": 62657, + "strid": "adbdcb0c-e0b6-437d-ab70-4100dabb5982", + "image_id": 202970, + "image_name": "119526.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 142.843, + 847.805, + 1065.599, + 1254.386 + ], + "priority": 4, + "parents": [ + 62660 + ], + "children": [], + "area": 121103.00961499999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 62662, + "strid": "81ac5d38-7950-483d-b63c-449a244dfc47", + "image_id": 202970, + "image_name": "119526.png", + 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Corral-Frias!, Emily M..Drabant2, Kelly Faig?,\nRyan Bogdan! and Ahmad R. Hariri*\n\n1. BRAINLab, ‘Department of Psychology, Washington University in St. Louis, St. Louis, MO, USA; 2. 23andMe, Mountain View,\nCA, USA;\\3s Department of Psychology, University of Chicago, Chicago, IL, USA; 4.-Laboratory of Neurogenetics, Department\nof Psychology & Neuroscience, Institute for Genome Sciences & Policy,,Duke University, Durham, NC, USA" + }, + { + "id": 86002, + "strid": "306f27b0-56e2-47c6-a54c-9937a0621ed0", + "image_id": 203847, + "image_name": "121017.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 919.472, + 884.313, + 769.345, + 113.13900000000001 + ], + "priority": 3, + "parents": [ + 86019 + ], + "children": [ + 86003, + 86006, + 86008, + 86004 + ], + "area": 813101.0427359999, + "iscrowd": 0, + "segmentation": [], + "text": "Background" + }, + { + "id": 86003, + "strid": "fab17aa0-569a-401d-b413-ff7e45d70830", + "image_id": 203847, + "image_name": "121017.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 72.769, + 1016.118, + 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"6616aef1-35ff-4b64-86de-72f26d77aa3d", + "image_id": 203412, + "image_name": "120187.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 488.493, + 49.655, + 3011.382, + 190.187 + ], + "priority": 1, + "parents": [ + 74709 + ], + "children": [], + "area": 24256.119915, + "iscrowd": 0, + "segmentation": [], + "text": "Evaluation of methodologies to assess intracellular cGMP levels induced by\nsoluble guanylate cyclase (SGC) stimulators in whole cells" + }, + { + "id": 74666, + "strid": "1c140a0b-84b9-479e-aa24-f22627da6b73", + "image_id": 203412, + "image_name": "120187.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 610.387, + 260.382, + 2728.1770000000006, + 105.094 + ], + "priority": 2, + "parents": [ + 74709 + ], + "children": [], + "area": 158933.787834, + "iscrowd": 0, + "segmentation": [], + "text": "Guang Liu\", Christina Butler’, Kim Long’, Renee Sarno, Rob Solinga?, Kim Tang®, Yueh-tyng Chien', Ken Carlson’ and Jeif Segal!\n‘Cellular and Molecular Pharmacology, 7DMPK, *Discovery Pharmacology, Ironwood Pharmaceuticals, Inc. Cambridge, MA, USA" + }, + { + "id": 74667, + "strid": "7d57557e-bbbf-4a80-a019-0caab982eb75", + "image_id": 203412, + "image_name": "120187.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 66.419, + 460.916, + 187.485, + 40.16199999999998 + ], + "priority": 3, + "parents": [ + 74709 + ], + "children": [ + 74677 + ], + "area": 30613.579803999997, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 74677, + "strid": "40358bda-853b-4053-a30f-e723dbf26c47", + "image_id": 203412, + "image_name": "120187.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 75.346, + 548.679, + 967.0250000000001, + 419.42500000000007 + ], + "priority": 4, + "parents": [ + 74667 + ], + "children": [], + "area": 41340.767934, + "iscrowd": 0, + "segmentation": [], + "text": "‘hwo methodologies were evaluated to assess cGMP responses‘elicited by sGC\nstimulators (YC-1, BAY 41-2272 and several Ironwood copapeunds) in whole cells: an\nLC-MS/MS-based bioanalytical method to directly meastire CGMP generated in Human\nEmbryonic Kidney (HEK) cells or a cGMP GloSensor(feporter-based assay in HEK\ncells. Both assays had excellent signal to noise, low variability (%CV and Z prime\nvalues) and were highly reproducible. Each assay enabled efficient characterization of\nsGC stimulators with regard to potency, effi¢acy(E,,,), and synergy with NO. The\nGloSensor assay had the benefits of rapid tufmaround time and the ability to measure\ncGMP response in real time with endpoihiand kinetic profiling. However, the\nGloSensor assay did not have the same résolution to differentiate compounds with\ndifferent maximal levels of stimulation, likely due to a narrower linear range based on\nits reporter-based amplification Ofthé signal. The LC-MS/MS assay had a linear range\nof detection that spanned neamy four logs and provided a very precise measure of\npotency and efficacy butwas a*more labor-intensive method." + }, + { + "id": 74668, + "strid": "87862d25-e95b-40fa-a917-8a0f0f187fe6", + "image_id": 203412, + "image_name": "120187.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 72.079, + 1044.633, + 284.707, + 47.45100000000002 + ], + "priority": 5, + "parents": [ + 74709 + ], + "children": [ + 74680, + 74678, + 74679 + ], + "area": 75296.102007, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 74678, + "strid": "e8e38d5a-92d8-44d7-8b82-0c51a0c56dd0", + "image_id": 203412, + "image_name": "120187.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 81.621, + 1124.882, + 922.954, + 600.3029999999999 + ], + "priority": 6, + "parents": [ + 74668 + ], + "children": [], + "area": 91813.993722, + "iscrowd": 0, + "segmentation": [], + "text": "Soluble guanylate cyclase (SGC) is a key enzyme in the nitric oxide (NO)-signaling\npathway~Upon binding of NO, sGC catalyzes synthesis of the second Méssenger\ncGMR, which produces vasorelaxation and inhibits smooth muscle, prdtiferation,\nléukocyte recruitment and platelet aggregation through a numbernofkdownstream\nmechanisms.\n\nThe NO-sGC-cGMP signaling pathway is of interest ag’a therapeutic target in\ncardiopulmonary disease, including pulmonary hypertension (PH). As shown in\nFigure 1A, PH is associated with reduced levels of NO, which results in decreased\nlevels of cGMP. Recent efforts have been centeréd’on identifying pharmacological\nagents that target the sGC-cGMP signaling pathway directly, such as\nphosphodiesterase inhibitors that increaseythe intracellular levels of CGMP by\nreducing its hydrolysis or sGC stimulatorswthat act directly on sGC to effect an\nincrease in cGMP synthesis. The recent*DA approval of Bayer’s sGC stimulator\nAdempas for PH supports this conéept: To successfully investigate the sGC-cGMP.\nsignaling pathway, it is necessaryAo have effective tools to measure the cellular\nformation of cGMP in a robust and’ quantitative way. In this work we described two\ndifferent methodologies, aeGloSensor assay and a LC-MS/MS method, to measure\nsGC stimulator-induced/EGMP responses in whole cells, and further evaluate the\npros and cons of these two methods, as shown in Figure 1B." + }, + { + "id": 74679, + "strid": "bdfe4154-7aed-4e8e-bbcf-10ac892436fb", + "image_id": 203412, + "image_name": "120187.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 91.321, + 1744.678, + 511.019, + 411.93000000000006 + ], + "priority": 7, + "parents": [ + 74668 + ], + "children": [ + 74681 + ], + "area": 159325.739638, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 74681, + "strid": "6130846a-ae39-4750-b00e-14e84c297c74", + "image_id": 203412, + "image_name": "120187.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 106.257, + 2162.531, + 401.892, + 39.710999999999785 + ], + "priority": 8, + "parents": [ + 74679 + ], + "children": [], + "area": 229784.05646700002, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1A: Pharmacological targets in the NO-sGC\nsignaling pathway in PH" + }, + { + "id": 74680, + "strid": "65f95890-5ea4-4de0-af55-3710678a2f67", + "image_id": 203412, + "image_name": "120187.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 635.394, + 1769.064, + 397.3610000000001, + 317.5429999999999 + ], + "priority": 9, + "parents": [ + 74668 + ], + "children": [ + 74682 + ], + "area": 1124052.651216, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 74682, + "strid": "457d53f7-af15-494d-bc6f-d1dac0542993", + "image_id": 203412, + "image_name": "120187.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 620.873, + 2117.247, + 432.55999999999995, + 19.30699999999979 + ], + "priority": 10, + "parents": [ + 74680 + ], + "children": [], + "area": 1314541.496631, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1B: Diagram of cGMP production and detection" + }, + { + "id": 74670, + "strid": 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13.483999999999924 + ], + "priority": 27, + "parents": [ + 74695 + ], + "children": [], + "area": 4008534.10429, + "iscrowd": 0, + "segmentation": [], + "text": "lable 2: Glosens@r aSsay consistency" + }, + { + "id": 74699, + "strid": "bb1816b3-ed1e-4a51-ae8e-ea5a6f15cdde", + "image_id": 203412, + "image_name": "120187.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1805.152, + 2238.684, + 486.9499999999998, + 12.958000000000084 + ], + "priority": 28, + "parents": [ + 74672 + ], + "children": [], + "area": 4041164.8999680006, + "iscrowd": 0, + "segmentation": [], + "text": "Variance is galct the ratio of the max/min replicate for EC, and E_... within each method" + }, + { + "id": 74696, + "strid": "70521453-4741-45b7-8ff1-3073c00f5289", + "image_id": 203412, + "image_name": "120187.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2121.787, + 2010.071, + 274.7080000000001, + 215.47299999999996 + ], + "priority": 29, + "parents": [ + 74672 + ], + 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}, + { + "id": 74707, + "strid": "0a625fee-26eb-432f-8c7a-4457b0475d96", + "image_id": 203412, + "image_name": "120187.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2580.372, + 583.073, + 472.4749999999999, + 477.7409999999999 + ], + "priority": 32, + "parents": [ + 74673 + ], + "children": [ + 74705 + ], + "area": 1504545.2431559998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 74705, + "strid": "6c037f07-1191-4383-8c3a-ceb300a20922", + "image_id": 203412, + "image_name": "120187.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2551.963, + 1069.469, + 615.913, + 59.480999999999995 + ], + "priority": 33, + "parents": [ + 74707 + ], + "children": [], + "area": 2729245.3176470003, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3: A set of 59 compounds were evaluated for their relative EG@;, Values\n(A) and E,,., (B). The results were compared between GloSe Sopass! (n=3)\nand LC-MS/MS method (n=2)." + }, + { + "id": 74674, + "strid": "e127e2a6-c897-4411-82a0-65983ce4fde9", + "image_id": 203412, + "image_name": "120187.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3280.098, + 456.793, + 618.663, + 102.03999999999996 + ], + "priority": 34, + "parents": [ + 74709 + ], + "children": [ + 74708 + ], + "area": 1498325.805714, + "iscrowd": 0, + "segmentation": [], + "text": "Both methods allow for the\ndetection of synergy with NO" + }, + { + "id": 74708, + "strid": "a6e90c23-befd-4973-ab6a-84ab0fa599aa", + "image_id": 203412, + "image_name": "120187.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3290.85, + 576.113, + 635.844, + 453.4280000000001 + ], + "priority": 35, + "parents": [ + 74674 + ], + "children": [ + 74706 + ], + "area": 1895901.4660500002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 74706, + "strid": "11095df3-8380-4cb6-8f2c-e7c65c1abf7e", + "image_id": 203412, + "image_name": "120187.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 3257.939, + 1031.834, + 644.5239999999999, + 100.89599999999996 + ], + "priority": 36, + "parents": [ + 74708 + ], + "children": [], + "area": 3361652.230126, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 5: Activities of sGC stimulators IWP-989 (A, C) and IWP-391 (B, D/were\nassessed at different concentrations of DETA-NO by GloSensor asgay (A, B) and\nLC-MS/MS method (C, D). Both methods detect the synergy of t GC\nstimulators with NO. However, LC-MS/MS seems to have higher séngitivity than\nGloSensor assay when DETA-NO concentration is low. aN" + }, + { + "id": 74675, + "strid": "461e9651-1552-4cc2-9702-a49cb948462d", + "image_id": 203412, + "image_name": "120187.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2598.255, + 1164.09, + 557.2240000000002, + 156.28199999999993 + ], + "priority": 37, + "parents": [ + 74709 + ], + "children": [ + 74701 + ], + "area": 3024602.66295, + "iscrowd": 0, + "segmentation": [], + "text": "GloSensor assay may not\ndifferentiate the activity of\npartial stimulators" + }, + { + "id": 74701, + "strid": "2754314a-79e6-4f9d-9bd8-8fe52f7ae3f3", + "image_id": 203412, + "image_name": "120187.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2541.109, + 1337.801, + 676.875, + 523.268 + ], + "priority": 38, + "parents": [ + 74675 + ], + "children": [ + 74703 + ], + "area": 3399498.1613089996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 74703, + "strid": "2e3820bb-01fe-43ad-a574-8b4ca8906212", + "image_id": 203412, + "image_name": "120187.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2566.259, + 1867.541, + 609.098, + 40.11400000000003 + ], + "priority": 39, + "parents": [ + 74701 + ], + "children": [], + "area": 4792593.899119, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 4: The GloSensor assay accurately detec} stimulator (A) and a\nweak stimulator (B), but has less resolution at finding\\partial stimulators (C)." + }, + { + "id": 74676, + "strid": "63ea3dbb-db18-450b-9bd5-d296dd6a48ed", + "image_id": 203412, + "image_name": "120187.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3287.643, + 1163.687, + 604.3969999999999, + 155.43599999999992 + ], + "priority": 40, + "parents": [ + 74709 + ], + "children": [ + 74702 + ], + "area": 3825787.4197409996, + "iscrowd": 0, + "segmentation": [], + "text": "GloSensor assay offers real-\ntime measurement of cGMP\nresponses in cells" + }, + { + "id": 74702, + "strid": "a0e15c00-daf3-480c-8c1e-e501950b6a13", + "image_id": 203412, + "image_name": "120187.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3258.963, + 1334.999, + 660.3119999999999, + 449.26700000000005 + ], + "priority": 41, + "parents": [ + 74676 + ], + "children": [ + 74704 + ], + "area": 4350712.346037, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 74704, + "strid": "3bc19356-cda2-46cc-90ab-e103e2cfa7e3", + "image_id": 203412, + "image_name": "120187.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 3262.105, + 1789.201, + 652.5619999999999, + 119.75600000000009 + ], + "priority": 42, + "parents": [ + 74702 + ], + "children": [], + "area": 5836561.528105, + "iscrowd": 0, + "segmentation": [], + "text": "using the GloSensor assay. Kinetic profiles are shown for t\\ mpound\nconcentrations, 117nM (B) and 7.5uM (C) that represent di stages of the\ncompound dose response curves (A). Individual comp displayed different\nkinetic responses at the same concentration. The s: pound at different\nconcentrations also displayed distinct kinetic reepee\n\nFigure 6: Time-dependence of cGMP-responses mediated thee sG@’stimulators" + }, + { + "id": 74669, + "strid": "7cc954a2-f451-4bfa-9f03-0e7b0afda053", + "image_id": 203412, + "image_name": "120187.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2529.849, + 1943.812, + 267.3130000000001, + 39.277000000000044 + ], + "priority": 43, + "parents": [ + 74709 + ], + "children": [ + 74700 + ], + "area": 4917550.844388, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 74700, + "strid": "fd101a4a-64ab-4afe-b580-4ca9d2b4cc7d", + "image_id": 203412, + "image_name": "120187.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2528.799, + 2009.293, + 1404.1149999999998, + 237.7360000000001 + ], + "priority": 44, + "parents": [ + 74669 + ], + "children": [], + "area": 5081098.129106999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 104347, + "strid": "a3d407a4-1aff-41bf-8e27-cbc7d79b551e", + "image_id": 204532, + "image_name": "122295.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 191.11, + 352.66, + 252.64, + 277.09 + ], + "priority": -1, + "parents": [], + "children": [ + 104335, + 104332, + 104334, + 104329, + 104328, + 104333, + 104330, + 104331 + ], + "area": 67396.85260000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 104328, + "strid": "5b5d2fc6-6d0f-438a-bdda-5aa3ec555c47", + "image_id": 204532, + "image_name": "122295.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 401.84, + 198.77, + 2709.708, + 355.05000000000007 + ], + "priority": 1, + "parents": [ + 104347 + ], + "children": [], + "area": 79873.7368, + "iscrowd": 0, + "segmentation": [], + "text": "Interaction Network Analysis links Tumor\n_~ Mutations with Expression Patterns" + }, + { + "id": 104329, + "strid": "26e77547-3ea2-4b5f-a7c6-a11cdbbaf580", + "image_id": 204532, + "image_name": "122295.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 817.48, + 620.041, + 1960.4860000000003, + 272.168 + ], + "priority": 2, + "parents": [ + 104347 + ], + "children": [], + "area": 506871.11668000004, + "iscrowd": 0, + "segmentation": [], + "text": "Christos Dimitrakopoulos', Jonas Behr’? and Ni keBeerenwinkel\n1. Swiss Institute of Bioinformatics\nLy ETH Zurich, D-BSSE, Basel, Switzerland" + }, + { + "id": 104330, + "strid": "928ded8e-976e-475a-8c09-fa496711cfd1", + "image_id": 204532, + "image_name": "122295.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 217.002, + 927.125, + 385.73099999999994, + 89.64700000000005 + ], + "priority": 3, + "parents": [ + 104347 + ], + "children": [ + 104340, + 104341 + ], + "area": 201187.97925, + "iscrowd": 0, + "segmentation": [], + "text": "Abstract" + }, + { + "id": 104341, + "strid": "04e2172f-9a5e-4941-8bd9-2ba72c685ffe", + "image_id": 204532, + "image_name": "122295.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 221.138, + 1043.205, + 1441.178, + 830.6570000000002 + ], + "priority": 4, + "parents": [ + 104330 + ], + "children": [], + "area": 230692.26729, + "iscrowd": 0, + "segmentation": [], + "text": "Somatic tumor mutation data is a valuable but not sufficient source to uncover\nnew cancer genes and pathways,.as the genomic alterations of same-clinical-\ntype tumors are extremely diverse. Based on graph diffusion methods we\nidentify groups of mutated genes (modules) with similar effects on the\nexpression patterns of downstream genes. Our approach addresses the\ncommon phenomenon. of mutational heterogeneity and simultaneous\nhomogeneity of expression patterns between patients. Based on known\nregulatory network connections we generate statistically sound hypothesis of\nhow common. expression changes in many patients can be achieved by\nmutations in various genes of the network. Our approach allows for detecting\nnetwork modules of mutated genes that cover a large number of samples with\nsignificantly different mutations, closely connected to the same differentially\nexpressed genes and can potentially handle different sources of differential\nexpression data and different types of interactions." + }, + { + "id": 104340, + "strid": "5c4561ca-283e-4249-a669-287b81030d95", + "image_id": 204532, + "image_name": "122295.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 635.363, + 1912.141, + 604.8990000000001, + 456.424 + ], + "priority": 5, + "parents": [ + 104330 + ], + "children": [], + "area": 1214903.6421830002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 104332, + "strid": "b0efba53-e4cc-4fc3-8970-4bde8e5daa2c", + "image_id": 204532, + "image_name": "122295.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 202.953, + 2394.62, + 685.818, + 92.6579999999999 + ], + "priority": 6, + "parents": [ + 104347 + ], + "children": [ + 104336, + 104344 + ], + "area": 485995.31286, + "iscrowd": 0, + "segmentation": [], + "text": "TCGA Database" + }, + { + "id": 104344, + "strid": "07c9909f-a119-471d-9fc6-c5306c7607ae", + "image_id": 204532, + "image_name": "122295.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 211.001, + 2532.042, + 1464.597, + 191.95199999999977 + ], + "priority": 7, + "parents": [ + 104332 + ], + "children": [], + "area": 534263.3940419999, + "iscrowd": 0, + "segmentation": [], + "text": "The Cancer Genome Atlas has helped set the standards for characterizing the\ngenomic underpinnings of dozens of cancers on a large scale which are all\n\nknown to exhibit large mutational heterogeneity. We run our methodology to\nthe well-studied breast invasive carcinoma." + }, + { + "id": 104336, + "strid": "3289969e-d5d3-48d9-b0a0-7616333e0b2e", + "image_id": 204532, + "image_name": "122295.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 164.209, + 2749.977, + 1517.659, + 1178.7020000000002 + ], + "priority": 8, + "parents": [ + 104332 + ], + "children": [], + "area": 451570.973193, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 104335, + "strid": "e48c272e-38c6-4711-b309-a718b75de345", + "image_id": 204532, + "image_name": "122295.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 201.707, + 3998.24, + 375.43999999999994, + 87.19900000000007 + ], + "priority": 9, + "parents": [ + 104347 + ], + "children": [ + 104345, + 104342 + ], + "area": 806472.9956799999, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 104345, + "strid": "7cdf7b03-574e-476e-b1c0-e918c82ab8a5", + "image_id": 204532, + "image_name": "122295.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 206.202, + 4121.215, + 1467.224, + 855.5779999999995 + ], + "priority": 10, + "parents": [ + 104335 + ], + "children": [], + "area": 849802.77543, + "iscrowd": 0, + "segmentation": [], + "text": "Influence Network of a Mutation: Use Random Walk with Restart to create\nconnectivity strengths between the mutated gene and the rest of the genes in\nthe network\n\n \n\nPry =A - a)W'p, + apy\nWw =A)? wal?\n\nAti] =) Wi\nJ\nFunctionally Linked Mutations: Two mutations are functionally linked if the\n\ncommon differentially expressed genes in their neighbourhoods are higher than\nexpected by chance\n\n \n\nPr(overlap => |ND(m1)NND(m2)|)\n\n_ 1 yee (INPoma)1) (\" _ pond)\n\n( ( y i=|ND(m1)NND(m2)| i |ND(m2)| —i\nND(m2" + }, + { + "id": 104342, + "strid": "00008637-fe6a-4589-89d1-464edf2b32a2", + "image_id": 204532, + "image_name": "122295.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1751.836, + 1048.652, + 1474.405, + 100.10300000000007 + ], + "priority": 11, + "parents": [ + 104335 + ], + "children": [], + "area": 1837066.325072, + "iscrowd": 0, + "segmentation": [], + "text": "Cluster of Mutations: Two or more mutations form a cluster of mutations if every\nsingle pair of mutations in the cluster are functionally linked" + }, + { + "id": 104331, + "strid": "08da63f8-09c8-47b1-8c96-b4e1cad697a6", + "image_id": 204532, + "image_name": "122295.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1750.823, + 1193.186, + 818.5260000000001, + 89.27999999999997 + ], + "priority": 12, + "parents": [ + 104347 + ], + "children": [ + 104343, + 104339, + 104338 + ], + "area": 2089057.492078, + "iscrowd": 0, + "segmentation": [], + "text": "Network Diffusion" + }, + { + "id": 104339, + "strid": "eeefba3d-dc66-450d-9ae7-f14fad196258", + "image_id": 204532, + "image_name": "122295.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1736.132, + 1392.453, + 1444.1929999999998, + 690.2759999999998 + ], + "priority": 13, + "parents": [ + 104331 + ], + "children": [], + "area": 2417482.211796, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 104343, + "strid": "9e98defc-7946-44ec-b44c-13aba14c59bf", + "image_id": 204532, + "image_name": "122295.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1754.476, + 2135.558, + 1470.4299999999998, + 147.78099999999995 + ], + "priority": 14, + "parents": [ + 104331 + ], + "children": [], + "area": 3746785.257608, + "iscrowd": 0, + "segmentation": [], + "text": "Cliques (clusters) of mutations are tested for statistical significance in their\ncoverage by performing a network permutation of the differentially expressed\ngenes labels." + }, + { + "id": 104338, + "strid": "74dc75ec-deff-4233-b11f-1a19eb52ea9b", + "image_id": 204532, + "image_name": "122295.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2068.394, + 2337.108, + 795.8310000000001, + 650.3119999999999 + ], + "priority": 15, + "parents": [ + 104331 + ], + "children": [], + "area": 4834060.164551999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 104333, + "strid": "07fb5b37-8764-4bb4-b3f7-9cc4dca49daa", + "image_id": 204532, + "image_name": "122295.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1765.758, + 3064.952, + 929.9269999999999, + 94.27399999999989 + ], + "priority": 16, + "parents": [ + 104347 + ], + "children": [ + 104337 + ], + "area": 5411963.513616, + "iscrowd": 0, + "segmentation": [], + "text": "Networks Uncovered" + }, + { + "id": 104337, + "strid": "f82a9a11-c373-4fb0-98e5-70b043de6ae1", + "image_id": 204532, + "image_name": "122295.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1871.056, + 3248.71, + 1466.0139999999997, + 1106.6660000000002 + ], + "priority": 17, + "parents": [ + 104333 + ], + "children": [], + "area": 6078518.3377600005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 104334, + "strid": "79ea3f3b-c24a-492b-9662-7285dbbfa01a", + "image_id": 204532, + "image_name": "122295.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1764.298, + 4494.494, + 486.91099999999983, + 89.81900000000041 + ], + "priority": 18, + "parents": [ + 104347 + ], + "children": [ + 104346 + ], + "area": 7929626.775211999, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 104346, + "strid": "4c4c15b2-8f95-4171-b90e-f926b6f3ba79", + "image_id": 204532, + "image_name": "122295.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1763.334, + 4641.384, + 1471.1810000000003, + 98.9340000000002 + ], + "priority": 19, + "parents": [ + 104334 + ], + "children": [], + "area": 8184310.214256001, + "iscrowd": 0, + "segmentation": [], + "text": "Cancer Genome Atlas Network, Comprehensive molecular portraits of human\nbreast tumors. Nature 490, 61-70 (2012)." + }, + { + "id": 61437, + "strid": "f48a988c-05ec-4225-9337-124540430f78", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 120.6, + 40.87, + 191.13000000000002, + 162.17 + ], + "priority": -1, + "parents": [], + "children": [ + 61378, + 61375, + 61402, + 61429, + 61410, + 61406, + 61393, + 61401, + 61412, + 61403, + 61404, + 61409, + 61411, + 61426, + 61414, + 61413, + 61408, + 61425, + 61377, + 61430, + 61407, + 61395, + 61376 + ], + "area": 4928.922, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61375, + "strid": "8829bc18-f0e8-457f-a632-1dce40a7ee3a", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 515.015, + 54.432, + 3202.261, + 118.407 + ], + "priority": 1, + "parents": [ + 61437 + ], + "children": [], + "area": 28033.29648, + "iscrowd": 0, + "segmentation": [], + "text": "Implementing the MNREAD Reading Acuity Fest on an iPad3" + }, + { + "id": 61376, + "strid": "d7f3ef58-a9c0-48c5-9cec-aa1abc834554", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 157.053, + 205.557, + 3924.487, + 174.251 + ], + "priority": 2, + "parents": [ + 61437 + ], + "children": [], + "area": 32283.343521, + "iscrowd": 0, + "segmentation": [], + "text": "wT\n\n‘© Aurelie Calabrese ', Safa Gamam ' J. Stephen Mansfield, Gordon E. Legge '\n1. Psychology, University of Minnesota, Minneapolis cNIN. 2. Psychology, State University of New York College at Plattsburgh, Plattsburgh, NY." + }, + { + "id": 61411, + "strid": "ad514e0d-40e6-4ada-923a-e697adb4c74f", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 424.415, + 594.034, + 573.5520000000001, + 103.87199999999996 + ], + "priority": 3, + "parents": [ + 61437 + ], + "children": [], + "area": 252116.94011, + "iscrowd": 0, + "segmentation": [], + "text": "Background" + }, + { + "id": 61412, + "strid": "74e5dd55-a4d3-4e32-94c3-009955317652", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 76.671, + 842.423, + 1176.459, + 88.06500000000005 + ], + "priority": 4, + "parents": [ + 61437 + ], + "children": [ + 61417, + 61415, + 61416 + ], + "area": 64589.413833000006, + "iscrowd": 0, + "segmentation": [], + "text": "What is the MNREAD Acuity Chart ?" + }, + { + "id": 61415, + "strid": 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"0340fa3c-0f05-4962-9423-dfe1327ad69f", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 78.466, + 2132.896, + 447.65, + 89.01099999999997 + ], + "priority": 10, + "parents": [ + 61437 + ], + "children": [ + 61423 + ], + "area": 167359.817536, + "iscrowd": 0, + "segmentation": [], + "text": "Advantages" + }, + { + "id": 61423, + "strid": "c1eded93-9743-4942-b553-106eef93304f", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 566.006, + 2106.59, + 745.276, + 232.05200000000013 + ], + "priority": 11, + "parents": [ + 61425 + ], + "children": [], + "area": 1192342.57954, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61426, + "strid": "32c5c93d-a587-49d0-a24b-eb0c2182071a", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 75.009, + 2392.153, + 421.724, + 90.73999999999978 + ], + "priority": 12, + "parents": [ + 61437 + ], + "children": [ + 61424, + 61427 + ], + "area": 179433.00437699998, + "iscrowd": 0, + "segmentation": [], + "text": "Challenges" + }, + { + "id": 61424, + "strid": "1cd697da-2415-45f2-9df6-5c988ce77ff7", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 638.944, + 2398.029, + 501.2640000000001, + 85.34700000000021 + ], + "priority": 13, + "parents": [ + 61426 + ], + "children": [], + "area": 1532206.241376, + "iscrowd": 0, + "segmentation": [], + "text": "What print size range can be\nrendered on the iPad?" + }, + { + "id": 61427, + "strid": "ea6efea7-c3db-4f6f-8729-9d3a944ae834", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 77.025, + 2503.057, + 1267.476, + 640.94 + ], + "priority": 14, + "parents": [ + 61426 + ], + "children": [], + "area": 192797.965425, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61429, + "strid": "47fc4697-379e-4401-952f-00aeddb00dec", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 72.91, + 3213.131, + 733.737, + 75.51400000000012 + ], + "priority": 15, + "parents": [ + 61437 + ], + "children": [ + 61428 + ], + "area": 234269.38121, + "iscrowd": 0, + "segmentation": [], + "text": "General Conclusion" + }, + { + "id": 61428, + "strid": "51d59ad6-f7cc-4465-97ea-902ef03d1b25", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 102.951, + 3321.155, + 1206.983, + 185.80000000000018 + ], + "priority": 16, + "parents": [ + 61429 + ], + "children": [], + "area": 341916.228405, + "iscrowd": 0, + "segmentation": [], + "text": "The iPad version & the printed*chart yield similar estimates of the\nMNREAD parameters (Maximum Reading Speed, Critical Print Size &\nReading Acuity) when testéd on both a normally-sighted population\nand’a‘low-vision population." + }, + { + "id": 61401, + "strid": "456b79bc-da84-463d-9a13-d1988df47c41", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1751.704, + 545.827, + 720.3280000000002, + 199.664 + ], + "priority": 17, + "parents": [ + 61437 + ], + "children": [], + "area": 956127.339208, + "iscrowd": 0, + "segmentation": [], + "text": "Experiment 1\n- Normal Vision -" + }, + { + "id": 61409, + "strid": "a2e52cee-9035-415e-aaf8-d3ee50492143", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1485.711, + 817.584, + 189.6790000000001, + 81.29100000000005 + ], + "priority": 18, + "parents": [ + 61437 + ], + "children": [ + 61419 + ], + "area": 1214693.542224, + "iscrowd": 0, + "segmentation": [], + "text": "Goal" + }, + { + "id": 61419, + "strid": "81279041-b457-4fbe-b493-0df9465f22ec", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1806.59, + 817.176, + 629.845, + 102.78300000000002 + ], + "priority": 19, + "parents": [ + 61409 + ], + "children": [], + "area": 1476301.98984, + "iscrowd": 0, + "segmentation": [], + "text": "To determinethe’smallest\nusable print)size’on the iPad3" + }, + { + "id": 61410, + "strid": "325b2a85-cdf4-4e9a-b154-3b5c5ae1e023", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1485.711, + 1007.262, + 329.67899999999986, + 81.29099999999994 + ], + "priority": 20, + "parents": [ + 61437 + ], + "children": [ + 61420, + 61421, + 61418 + ], + "area": 1496500.2332819998, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 61421, + "strid": "59f2401e-bc6e-45f4-9a0b-f317a9834137", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1941.642, + 996.449, + 709.9199999999998, + 136.24699999999996 + ], + "priority": 21, + "parents": [ + 61410 + ], + "children": [], + "area": 1934747.229258, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61418, + "strid": "32616ae2-89fc-4919-8d3e-716c0586fbd2", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1491.022, + 1175.578, + 953.3959999999997, + 634.817 + ], + "priority": 22, + "parents": [ + 61410 + ], + "children": [], + "area": 1752812.6607159998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61420, + "strid": "3ac0c41c-cc47-4ede-aaf2-819b9763244d", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2325.286, + 1327.506, + 425.47400000000016, + 326.27600000000007 + ], + "priority": 23, + "parents": [ + 61410 + ], + "children": [], + "area": 3086831.1167160003, + "iscrowd": 0, + "segmentation": [], + "text": "By manipulating\nthe viewing distance,\nwe evaluated the\nsmallest'print size\nthat ean be displayed\nwithesufficient resolution\non the iPad" + }, + { + "id": 61414, + "strid": "7abc8355-834c-41a1-a923-96141dd5f48d", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1491.727, + 1868.931, + 269.96399999999994, + 72.471 + ], + "priority": 24, + "parents": [ + 61437 + ], + "children": [ + 61436, + 61433, + 61434, + 61435 + ], + "area": 2787934.833837, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 61433, + "strid": "0d94d25c-1395-48a2-ba35-bfe4fdea66ec", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1487.348, + 1961.9, + 601.3559999999998, + 590.3330000000001 + ], + "priority": 25, + "parents": [ + 61414 + ], + "children": [], + "area": 2918028.0412, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61436, + "strid": "258f7ec8-6601-4461-8789-aa9b8f157f68", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1606.149, + 2598.774, + 356.30099999999993, + 139.39399999999978 + ], + "priority": 26, + "parents": [ + 61414 + ], + "children": [], + "area": 4174018.2613259996, + "iscrowd": 0, + "segmentation": [], + "text": "Reading speed is\n60% slower at 20cm\n(95% Cl [55,63])" + }, + { + "id": 61434, + "strid": "276815e4-693f-42f2-8b44-c5e66f1a75c8", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2146.267, + 1955.777, + 600.1309999999999, + 596.4569999999999 + ], + "priority": 27, + "parents": [ + 61414 + ], + "children": [], + "area": 4197619.634459, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61435, + "strid": "f14f96fd-cd6e-45ec-ac20-bde87ac59db7", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2300.586, + 2601.223, + 346.6060000000002, + 142.07200000000012 + ], + "priority": 28, + "parents": [ + 61414 + ], + "children": [], + "area": 5984337.216677999, + "iscrowd": 0, + "segmentation": [], + "text": "Reading speed is\n'4%.slower at 20cm\n(95% Cl [4.5,20])" + }, + { + "id": 61430, + "strid": "6c546499-cd35-4e69-a34d-05bd29cbf3c6", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1484.898, + 2882.918, + 458.05899999999997, + 78.38400000000001 + ], + "priority": 29, + "parents": [ + 61437 + ], + "children": [ + 61432, + 61431 + ], + "area": 4280839.172364, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 61431, + "strid": "09ad3eeb-6ae0-4e1a-8ddd-59fb03e90ac1", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1475.1, + 3032.338, + 540.1179999999999, + 423.7660000000001 + ], + "priority": 30, + "parents": [ + 61430 + ], + "children": [], + "area": 4473001.7838, + "iscrowd": 0, + "segmentation": [], + "text": "Only 14 print sizes in\n0.1 logMAR increments_can be\ndisplayed reliably On'the iPad\n(vs. 19 on the’chart)\n\nThis reduced number\ncan beyovercome by\nchanging,the viewing distance\nfor both normal & low vision" + }, + { + "id": 61432, + "strid": "bd05f211-f67d-460e-83da-455e5a236e2a", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2058.084, + 2920.885, + 678.5149999999999, + 589.1080000000002 + ], + "priority": 31, + "parents": [ + 61430 + ], + "children": [], + "area": 6011426.68434, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61378, + "strid": "471583a7-ddf0-4459-8306-0f513db7ae97", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3146.426, + 541.721, + 730.1730000000002, + 208.654 + ], + "priority": 32, + "parents": [ + 61437 + ], + "children": [], + "area": 1704485.039146, + "iscrowd": 0, + "segmentation": [], + "text": "Experiment 2\n- Normal Vision -" + }, + { + "id": 61407, + "strid": "044acfa7-c000-4c94-9d5a-866a099afca2", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2884.706, + 834.315, + 181.64400000000023, + 75.34699999999998 + ], + "priority": 33, + "parents": [ + 61437 + ], + "children": [ + 61380, + 61379 + ], + "area": 2406753.48639, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 61379, + "strid": "5432119c-f0a7-42ae-af91-68f7c6901041", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3132.145, + 820.273, + 970.6709999999998, + 103.99900000000002 + ], + "priority": 34, + "parents": [ + 61407 + ], + "children": [], + "area": 2569213.975585, + "iscrowd": 0, + "segmentation": [], + "text": "eo compare the Maximum Reading Speed,\nGritical Print Size & Reading Acuity assessedé" + }, + { + "id": 61380, + "strid": "0b076847-0141-4e8c-8470-665715cb313c", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3172.897, + 929.719, + 905.9499999999998, + 100.66100000000006 + ], + "priority": 35, + "parents": [ + 61407 + ], + "children": [], + "area": 2949902.625943, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61406, + "strid": "95b4b397-e960-4940-b21a-683dc0e3c0b2", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2889.18, + 1119.411, + 321.0720000000001, + 67.93599999999992 + ], + "priority": 36, + "parents": [ + 61437 + ], + "children": [ + 61381, + 61405 + ], + "area": 3234179.87298, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 61381, + "strid": "22ff7334-6bee-4a93-a47d-8623d518b231", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3331.524, + 1104.517, + 546.0009999999997, + 89.28899999999999 + ], + "priority": 37, + "parents": [ 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"898ede45-1d41-4dad-8117-87ea489cbeda", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2945.398, + 1536.666, + 463.3899999999999, + 274.6980000000001 + ], + "priority": 40, + "parents": [ + 61408 + ], + "children": [], + "area": 4526092.963068, + "iscrowd": 0, + "segmentation": [], + "text": "Maximum Reading Speed\nis 4% slower with the\niPad (95% Cl [2.6%,5.6%))\n\nNo significant effect of the\nviewing*distance" + }, + { + "id": 61397, + "strid": "e7bfae9b-f3c8-4107-b1a2-9c39b36e15ca", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2863.27, + 1933.194, + 572.5239999999999, + 556.038 + ], + "priority": 41, + "parents": [ + 61408 + ], + "children": [], + "area": 5535256.38438, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61400, + "strid": "186dbdcd-e15e-4528-a42f-d8fb4e0831ae", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3546.509, + 1406.085, + 552.6959999999999, + 565.7 + ], + "priority": 42, + "parents": [ + 61408 + ], + "children": [], + "area": 4986693.107265, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61399, + "strid": "78ffb576-1406-46f8-beb0-f6a040e511b1", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3574.989, + 2022.46, + 517.973, + 368.68100000000004 + ], + "priority": 43, + "parents": [ + 61408 + ], + "children": [], + "area": 7230272.25294, + "iscrowd": 0, + "segmentation": [], + "text": "Critical Print Size\nis 0.04 logMAR larger with\nthe iPad (95% @bhk{002, 0.07])\n\nCriticalPrint Size\nis decreased by 0.07 logMAR\nforeach Tm increase on both\ndisplays (95% Cl [0.05,0.09])" + }, + { + "id": 61398, + "strid": "bd90c58d-bbd5-47f8-a730-67b5e3fa7c84", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 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"text": "Maximum Reading Speed\nis the same with both\njisplays (95% Cl [-8%,5%])\n\nMaximum Reading Speed\nis 7% slower with the\nreversed contrast\n(95% Cl [0.2%,14.5%])" + }, + { + "id": 61387, + "strid": "56110812-d4fb-4d80-92dd-90971e1ef58b", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 4937.559, + 1468.147, + 549.049, + 558.827 + ], + "priority": 56, + "parents": [ + 61404 + ], + "children": [], + "area": 7249062.433173, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61388, + "strid": "de99edab-3167-4577-ac22-e709ce4be48c", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 4295.267, + 2036.195, + 548.4470000000001, + 550.9350000000002 + ], + "priority": 57, + "parents": [ + 61404 + ], + "children": [], + "area": 8746001.189065, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61389, + "strid": "3c5e8bec-0005-4041-9f10-eca58a860898", + 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{ + "id": 61390, + "strid": "41ff87fa-1b88-451d-a961-71d52eae8f65", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 4956.886, + 2564.744, + 548.4470000000001, + 547.2040000000002 + ], + "priority": 60, + "parents": [ + 61404 + ], + "children": [], + "area": 12713143.627184002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61393, + "strid": "35bee128-3f3e-4ba3-89de-b82d8ff4f0aa", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4290.444, + 3226.08, + 451.96399999999994, + 75.53699999999981 + ], + "priority": 61, + "parents": [ + 61437 + ], + "children": [ + 61392 + ], + "area": 13841315.57952, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 61392, + "strid": "0f0cd0b2-f337-43ab-ab74-d18832474f15", + "image_id": 202923, + "image_name": "119454.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 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Chromatin immunoprecipitation experiments in conjunction with Hidden Markov Models have been instrumental\nto understand these processes, for they segment the genome into discrete states which can then be related to DNA-associated protein complexes. However,\ncurrent Hidden Markov Model based approaches are not able to assign forward or reverse direction to states or properly integrate strand-specific (e.g. RNA\nexpression) with non-strand-specific (e.g. ChIP) data, which is indispensable to accurately characterize directed genomic processes. To overcome these\nlimitations, we introduce bidirectional Hidden Markov Models which infer directed genomic states from occupancy profiles de novo. We anticipate bidirectional\nHidden Markov Models to significantly improve analyses of genome-associated directed processes." + }, + { + "id": 98745, + "strid": "92a12c01-a1a8-4aac-a575-e1f036f8e541", + "image_id": 204322, + "image_name": "121877.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 357.812, + 1180.128, + 1148.6020000000003, + 57.458000000000084 + ], + "priority": 5, + "parents": [ + 98763 + ], + "children": [ + 98760, + 98761 + ], + "area": 422263.959936, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 98761, + "strid": "ab640b95-f822-4d1d-a60a-5299157b5b5a", + "image_id": 204322, + "image_name": "121877.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 70.95, + 1282.534, + 668.871, + 673.9099999999999 + ], + "priority": 6, + "parents": [ + 98745 + ], + "children": [], + "area": 90995.78730000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 98760, + "strid": "7b9f8c16-c66d-477d-9c4c-851a3bccfbb7", + "image_id": 204322, + "image_name": "121877.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 773.969, + 1343.798, + 1013.5720000000001, + 595.673 + ], + "priority": 7, + "parents": [ + 98745 + ], + "children": [], + "area": 1040057.9942620001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 98747, + "strid": "5a6be898-77e3-4df0-a564-1ca88661b607", + "image_id": 204322, + "image_name": "121877.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 135.351, + 2039.219, + 1589.8219999999997, + 142.92099999999982 + ], + "priority": 8, + "parents": [ + 98763 + ], + "children": [ + 98759, + 98751 + ], + "area": 276010.330869, + "iscrowd": 0, + "segmentation": [], + "text": "Genome-wide annotation of transcription states in\nBee neta" + }, + { + "id": 98751, + "strid": "12ea0454-4001-44b8-b4b8-0d165faed897", + "image_id": 204322, + "image_name": "121877.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 97.984, + 2209.563, + 699.37, + 878.7600000000002 + ], + "priority": 9, + "parents": [ + 98747 + ], + "children": [], + "area": 216501.820992, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 98759, + "strid": "617465ef-b8a6-4f2a-af04-407bfdf77f89", + "image_id": 204322, + "image_name": "121877.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 859.726, + 2291.41, + 908.476, + 687.0920000000001 + ], + "priority": 10, + "parents": [ + 98747 + ], + "children": [], + "area": 1969984.75366, + "iscrowd": 0, + "segmentation": [], + "text": "De novo, genome-wide annotation of\ntranscription states in yeast using bdHMM\nfrom transcription. factor occupancy maps\nand strand-specific expression data.\n\nInferred directed genomic states are shown\nas colored boxes in the lowest track (see\ncolor legend beneath) where expressed\nstates on the + (respectively -) strand are\npositioned above (respectively under) the\naxis, and unexpressed states are centered\non the axis. Previous transcriptome\nannotation is shown in the 2nd track from the\nbottom." + }, + { + "id": 98749, + "strid": "3bafc3e3-5543-4bda-9384-63b087f78f33", + "image_id": 204322, + "image_name": "121877.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 135.744, + 3164.406, + 1594.036, + 126.76099999999997 + ], + "priority": 11, + "parents": [ + 98763 + ], + "children": [ + 98754, + 98753 + ], + "area": 429549.128064, + "iscrowd": 0, + "segmentation": [], + "text": "The yeast transcription cycle shows gene-specific\noN variation" + }, + { + "id": 98753, + "strid": "e3b0623f-99ec-4d79-ade2-1ea298d5b5fe", + "image_id": 204322, + "image_name": "121877.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 167.822, + 3348.627, + 1468.9589999999998, + 887.7249999999999 + ], + "priority": 12, + "parents": [ + 98749 + ], + "children": [], + "area": 561973.280394, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 98754, + "strid": "fd97f9e0-99e8-4546-822b-29c730fc42a7", + "image_id": 204322, + "image_name": "121877.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 90.353, + 4260.85, + 1605.275, + 347.6970000000001 + ], + "priority": 13, + "parents": [ + 98749 + ], + "children": [], + "area": 384980.58005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 98746, + "strid": "ac7d46d0-3943-4735-a7f6-247ada9a5a23", + "image_id": 204322, + "image_name": "121877.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1935.822, + 1175.107, + 1243.3989999999997, + 150.2840000000001 + ], + "priority": 14, + "parents": [ + 98763 + ], + "children": [ + 98758, + 98762 + ], + "area": 2274797.9829539997, + "iscrowd": 0, + "segmentation": [], + "text": "bdHMM predicts genomic features with\n_ high accuracy" + }, + { + "id": 98762, + "strid": "597bcbda-2913-4232-8740-1a632daea13b", + "image_id": 204322, + "image_name": "121877.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1995.672, + 1362.49, + 1120.0679999999998, + 778.9739999999999 + ], + "priority": 15, + "parents": [ + 98746 + ], + "children": [], + "area": 2719083.14328, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 98758, + "strid": "67fe20c8-c560-4aee-be87-988ce39a447b", + "image_id": 204322, + "image_name": "121877.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1876.319, + 2161.114, + 1367.529, + 296.288 + ], + "priority": 16, + "parents": [ + 98746 + ], + "children": [], + "area": 4054939.259366, + "iscrowd": 0, + "segmentation": [], + "text": "Regular expressions are used to discover specific genomic features\nfrom the state annotation (A) The vast majority of annotated and new\ntranscripts are predicted from the state annotation (C) and\nbidirectional. promoters (B) are identified. (D) bdHMM.§ state\nannotation recovers annotated transcript boundaries with up to two-\nfold accuracy as compared to standard HMM." + }, + { + "id": 98748, + "strid": "7c152e75-2f94-4483-926d-dcbbde1a6798", + "image_id": 204322, + "image_name": "121877.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1937.452, + 2525.267, + 1234.3059999999998, + 136.56399999999985 + ], + "priority": 17, + "parents": [ + 98763 + ], + "children": [ + 98752, + 98755 + ], + "area": 4892583.599684, + "iscrowd": 0, + "segmentation": [], + "text": "pono improves annotation of human\nchromatin sta" + }, + { + "id": 98752, + "strid": "fdf525d6-7fc1-475e-8dfa-72aa455a2bde", + "image_id": 204322, + "image_name": "121877.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1993.458, + 2687.826, + 1086.2059999999997, + 860.721 + ], + "priority": 18, + "parents": [ + 98748 + ], + "children": [], + "area": 5358068.242308, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 98755, + "strid": "79963c0f-a66f-45f5-9b21-eb7e43acf409", + "image_id": 204322, + "image_name": "121877.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1886.656, + 3571.472, + 1345.937, + 445.2959999999998 + ], + "priority": 19, + "parents": [ + 98748 + ], + "children": [], + "area": 6738139.077632001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 98750, + "strid": "e5d65c40-2db2-428d-82d2-848d04dac2c5", + "image_id": 204322, + "image_name": "121877.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2381.402, + 4122.634, + 363.67599999999993, + 57.514000000000124 + ], + "priority": 20, + "parents": [ + 98763 + ], + "children": [ + 98756 + ], + "area": 9817648.852868, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion" + }, + { + "id": 98756, + "strid": "37278d4e-bb42-481f-bb3c-ee48c70906a9", + "image_id": 204322, + "image_name": "121877.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1885.792, + 4250.979, + 1342.966, + 338.14400000000023 + ], + "priority": 21, + "parents": [ + 98750 + ], + "children": [], + "area": 8016462.190368, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 106409, + "strid": "ab03fb63-c67c-45ee-87d1-494969b9a22a", + "image_id": 204619, + "image_name": "12560.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 572.85, + 27.82, + 71.64999999999998, + 92.4 + ], + "priority": -1, + "parents": [], + "children": [ + 106391, + 106388, + 106387, + 106392, + 106390, + 106386, + 106389 + ], + "area": 15936.687, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 106386, + "strid": "e5343960-4287-42c9-ac86-4b36d6091887", + "image_id": 204619, + "image_name": "12560.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 32.416, + 32.603, + 534.6990000000001, + 76.66999999999999 + ], + "priority": 1, + "parents": [ + 106409 + ], + "children": [], + "area": 1056.8588479999999, + "iscrowd": 0, + "segmentation": [], + "text": "What does MSF publish in medical\njournals and how accessible is it?" + }, + { + "id": 106387, + "strid": "3725b58c-a7af-4de4-adca-acfe7930ce94", + "image_id": 204619, + "image_name": "12560.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 34.125, + 152.535, + 245.68, + 14.120000000000005 + ], + "priority": 2, + "parents": [ + 106409 + ], + "children": [], + "area": 5205.256875, + "iscrowd": 0, + "segmentation": [], + "text": "ia Kahn and Michelle Olakkengii" + }, + { + "id": 106388, + "strid": "f99349ec-f750-4546-a7ef-b8d35d151ba4", + "image_id": 204619, + "image_name": "12560.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 34.771, + 221.743, + 99.908, + 12.153999999999996 + ], + "priority": 3, + "parents": [ + 106409 + ], + "children": [ + 106393 + ], + "area": 7710.225853, + "iscrowd": 0, + "segmentation": [], + "text": "Background & Aims" + }, + { + "id": 106393, + "strid": "4498f933-2748-4665-9fd1-01bae57e5a54", + "image_id": 204619, + "image_name": "12560.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 34.916, + 248.445, + 171.462, + 379.67 + ], + "priority": 4, + "parents": [ + 106388 + ], + "children": [], + "area": 8674.705619999999, + "iscrowd": 0, + "segmentation": [], + "text": "ee ee eee eee ee ae\nmore peer-reviewed medical journal\nancies based on our operational\nresearch and advocacy work. These\npapers are key to our otforts to be\nransparent about what we do, share\nhe data and knowledge gained, and\nuse our collected evidence to\nadvocate for improved global healt\npractice and policy. Some of ou\npublications also rellect collabora:\nlone with non MSF researchers and\nglobal heath actors, including\nsupport for work by trainees and\nresearchers in the countries whe\nwe work,\n\n \n\nHore we present an overview o\n“core” MSF aricles—those reporting\non MSF projects. and data, andio\nauthored \"principally by _ MSF—\npublished in peer-reviewed journal\nin 2017. Given MSF objectives\nransparency and wide dissemination\nof our work (which apply as well to\ndata sharing), we also determine the\nproportion of these core papers thal\nare available to readers everywhe\nor tr, and estimate the extra costs\nof raising this proportion to 100%." + }, + { + "id": 106391, + "strid": "f49977e2-66e9-46b1-89b5-8ae8ed262432", + "image_id": 204619, + "image_name": "12560.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 35.548, + 656.774, + 42.51599999999999, + 9.380999999999972 + ], + "priority": 5, + "parents": [ + 106409 + ], + "children": [ + 106398 + ], + "area": 23347.002152, + "iscrowd": 0, + "segmentation": [], + "text": "Mathods" + }, + { + "id": 106398, + "strid": "45124f79-d259-4b50-aa1e-195eea85ff97", + "image_id": 204619, + "image_name": "12560.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 33.753, + 679.114, + 173.925, + 451.58500000000004 + ], + "priority": 6, + "parents": [ + 106391 + ], + "children": [], + "area": 22922.134842, + "iscrowd": 0, + "segmentation": [], + "text": "Fach week MSP-USA Identifies\nnelwy-published MSF journal articles\nthrough Google Scholar, PubMed\nand manual scans of key journals,\nand enters them into an intemal\ndatabase using Microsolt_ Access\n2013 (and info the public MSF Field\nResearch Database). Articles with at\nleast one MSFaffilated author and\npublished in electroncaly-availabe,\npeer reviewed journals, ar included.\nEach year's lst is checked with OC's\nand Epicenre. n 2017 ths led tothe\ninclusion of 238 articles.\n\nHere we analyze a subset of “core\nMSF papers, as defined by several\nciter. For research articles, these\nwere: (1) contain data from MSF\nprojec; (2) where requited, study\nwas approved by MSF Ethics Review\nBoard or Comité de Protection des\nPersonnes, plus national bodies: (3)\nreceived MSF funding: (4) had. at\nleast one author with MSF as his her\nprimary afflaion. For other article\ntypes (0.9. commentaries, meta-\nanalyses), crteria were: (1) discuss\nMSF data, work topics andlor\nexperiences: (2) MSF frst author or\npredominantly MSF authors. By\nthese criteria, the core data set\nincluded 168 articles.\n\nLimitations included the possibilty of\noccasionally missing an MSF article." + }, + { + "id": 106389, + "strid": "d7730b2d-7111-4e8f-bd7a-4d0c3717b54c", + "image_id": 204619, + "image_name": "12560.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 226.565, + 222.229, + 37.435, + 9.966000000000008 + ], + "priority": 7, + "parents": [ + 106409 + ], + "children": [ + 106404, + 106403, + 106395, + 106406, + 106394, + 106396, + 106400, + 106399, + 106402, + 106401, + 106397, + 106405 + ], + "area": 50349.313385, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 106397, + "strid": "b432d83e-9b0a-4ff3-b387-e6819e401f62", + "image_id": 204619, + "image_name": "12560.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 348.026, + 222.745, + 81.59800000000001, + 10.516999999999996 + ], + "priority": 8, + "parents": [ + 106389 + ], + "children": [], + "area": 77521.05137, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 106394, + "strid": "cefafe93-bd50-4a75-89b3-4bb155a47fc4", + "image_id": 204619, + "image_name": "12560.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 224.268, + 243.361, + 363.41499999999996, + 338.70400000000006 + ], + "priority": 9, + "parents": [ + 106389 + ], + "children": [], + "area": 54578.084748, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 106399, + "strid": "89e640be-96db-41ef-ba72-bac38a7e0942", + "image_id": 204619, + "image_name": "12560.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 322.703, + 587.574, + 142.18100000000004, + 12.561000000000035 + ], + "priority": 10, + "parents": [ + 106389 + ], + "children": [], + "area": 189611.89252199998, + "iscrowd": 0, + "segmentation": [], + "text": "Free access to MSF papers?" + }, + { + "id": 106404, + "strid": "41f96267-3c30-48d9-a78b-ba1b2072e503", + "image_id": 204619, + "image_name": "12560.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 237.254, + 607.494, + 225.366, + 182.56600000000003 + ], + "priority": 11, + "parents": [ + 106389 + ], + "children": [], + "area": 144130.381476, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 106400, + "strid": "c3059730-a2de-4dd9-a753-e150444cbdf0", + "image_id": 204619, + "image_name": "12560.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 471.18, + 604.615, + 125.67500000000001, + 76.35900000000004 + ], + "priority": 12, + "parents": [ + 106389 + ], + "children": [], + "area": 284882.4957, + "iscrowd": 0, + "segmentation": [], + "text": "eee ee\nAuthor pays publication\nfee & ovsns copyright; can\nuse, distibute & post art-\ncle online. Some ournals\npublish only OA papers," + }, + { + "id": 106401, + "strid": "168a4eb3-19dc-42b0-8239-de889fa5ef3a", + "image_id": 204619, + "image_name": "12560.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 470.65, + 693.171, + 126.73500000000001, + 84.31399999999996 + ], + "priority": 13, + "parents": [ + 106389 + ], + "children": [], + "area": 326240.93115, + "iscrowd": 0, + "segmentation": [], + "text": "Byes De Pee. Fae\npublication fee to joumal\nthat's, mosty subsciption=\nbased but also gives\nauthors the option to\npublish OA. Many journals\nSe cian" + }, + { + "id": 106402, + "strid": "e846e171-80ab-4c71-9f18-f77e9db53162", + "image_id": 204619, + "image_name": "12560.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 230.436, + 796.044, + 363.7679999999999, + 36.589000000000055 + ], + "priority": 14, + "parents": [ + 106389 + ], + "children": [], + "area": 183437.195184, + "iscrowd": 0, + "segmentation": [], + "text": "Free st publlcation: Free for readers on journal webeRe but Journ) reteins\ncopytight (so authors are resticted in using or posting artce). Offered by a\nig Was sie 18 tered Calo daiane’ ice teens tes ceeded de" + }, + { + "id": 106403, + "strid": "dcde77d6-921f-4593-a346-86534511a100", + "image_id": 204619, + "image_name": "12560.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 230.966, + 841.117, + 340.43600000000004, + 13.256999999999948 + ], + "priority": 15, + "parents": [ + 106389 + ], + "children": [], + "area": 194269.429022, + "iscrowd": 0, + "segmentation": [], + "text": "Free after 6 or 12 months: Free on journal website after embargo period." + }, + { + "id": 106405, + "strid": "6cbee71a-148c-4361-8ff8-37ff0b7ad26f", + "image_id": 204619, + "image_name": "12560.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 233.238, + 863.969, + 364.31299999999993, + 127.73699999999997 + ], + "priority": 16, + "parents": [ + 106389 + ], + "children": [], + "area": 201510.401622, + "iscrowd": 0, + "segmentation": [], + "text": "ee a\nWhile cost is sometimes raised at MSF as an obstacle to OA publishing, of to\nadopting policies that would mandate OA, there are few data on actual\nexpenditures. Here we estimate current OA outlays (by totaling lees for each\n2017 OA arlcle) and the extra costs that would arise Irom making all articles\nOA (by adding in fees of hybrid journals whore MSF published non-OA papers\nplus a weighled average fee for remaining papers). Numerous journals grant\nMSF authors 2 75% discount if requested (using a specific, well-honed\nrationale) for individual papers. We tharetore also estimated the decrease in\ncosts if discounts were regularly requested and granted from these journals." + }, + { + "id": 106406, + "strid": "812a49b6-cb5b-4129-8adc-9b9619c1f5b9", + "image_id": 204619, + "image_name": "12560.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 228.891, + 999.923, + 362.53100000000006, + 131.19499999999994 + ], + "priority": 17, + "parents": [ + 106389 + ], + "children": [], + "area": 228873.375393, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 106396, + "strid": "bfac2cd3-6942-45fd-9194-4fa434fca15d", + "image_id": 204619, + "image_name": "12560.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 650.425, + 222.219, + 86.84400000000005, + 11.187000000000012 + ], + "priority": 18, + "parents": [ + 106389 + ], + "children": [], + "area": 144536.793075, + "iscrowd": 0, + "segmentation": [], + "text": "Where we publish" + }, + { + "id": 106395, + "strid": "c86294f0-5b7b-498c-8455-c27c36b51c65", + "image_id": 204619, + "image_name": "12560.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 605.211, + 238.075, + 200.89999999999998, + 267.928 + ], + "priority": 19, + "parents": [ + 106389 + ], + "children": [], + "area": 144085.608825, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 106390, + "strid": "4ac95519-987c-44f4-a650-de817599a393", + "image_id": 204619, + "image_name": "12560.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 615.844, + 522.986, + 62.398000000000025, + 8.612999999999943 + ], + "priority": 20, + "parents": [ + 106409 + ], + "children": [ + 106407 + ], + "area": 322077.79018400004, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 106407, + "strid": "a372a23f-647c-40e8-b62b-0254a41802ad", + "image_id": 204619, + "image_name": "12560.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 615.28, + 542.16, + 171.27499999999998, + 348.07499999999993 + ], + "priority": 21, + "parents": [ + 106390 + ], + "children": [], + "area": 333580.20479999995, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 106392, + "strid": "df59a961-e0a7-485d-bf66-713b27a515c4", + "image_id": 204619, + "image_name": "12560.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 611.46, + 919.295, + 96.75199999999995, + 11.474000000000046 + ], + "priority": 22, + "parents": [ + 106409 + ], + "children": [ + 106408 + ], + "area": 562112.1207, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements" + }, + { + "id": 106408, + "strid": "4cf472da-2276-4274-bfde-651cda42e64f", + "image_id": 204619, + "image_name": "12560.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 611.494, + 939.988, + 172.83799999999997, + 98.7650000000001 + ], + "priority": 23, + "parents": [ + 106392 + ], + "children": [], + "area": 574797.0220720001, + "iscrowd": 0, + "segmentation": [], + "text": "Big thanks to the people who helped\nvalidate our data sets Yap Boum\nBarbara Nasto, Aminata Ndiaye &\nBrigite Vasset: to Tony Reid, our\npariner in collecting and dssem-\ninating MSF publication information:\nand to Janet Ousiey for many ful\ndlecussions." + }, + { + "id": 141849, + "strid": "a2e801ca-6ba0-48c3-ab46-af462c6494b5", + "image_id": 206014, + "image_name": "16981.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 33.03, + 217.12, + 188.52, + 152.02999999999997 + ], + "priority": -1, + "parents": [], + "children": [ + 141831, + 141828, + 141833, + 141832, + 141827, + 141830, + 141829, + 141834 + ], + "area": 7171.4736, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 141827, + "strid": "04c5d16e-053f-4011-932d-55dde55985f1", + "image_id": 206014, + "image_name": "16981.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 32.243, + 22.713, + 2554.34, + 74.45600000000002 + ], + "priority": 1, + "parents": [ + 141849 + ], + "children": [], + "area": 732.3352590000001, + "iscrowd": 0, + "segmentation": [], + "text": "TAGOPSIN: a tool for retrieving taxa-specific protein structural and functional information" + }, + { + "id": 141828, + "strid": "a5da8a74-fa8a-4641-8ac6-825be9460eac", + "image_id": 206014, + "image_name": "16981.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 40.917, + 119.703, + 2822.182, + 228.898 + ], + "priority": 2, + "parents": [ + 141849 + ], + "children": [], + "area": 4897.887651, + "iscrowd": 0, + "segmentation": [], + "text": "Eshan Bundhoo!, Anisah Ghoorah2* and Yasmina Jaufeerally-Fakim! LY\n\n1 Department of Agricultural & Food Science, Faculty of Agriculture, University of Mauritius, 7/7\n\n2 Department of Digital Technologies, Faculty of Information, Communication & Digital Technologies, University of Mauritius, Reduit 80837, Mauritius\n* Corresponding Author. E-mail: a.ghoorah@uom.ac.mu\n\nRTA" + }, + { + "id": 141829, + "strid": "68761d41-66ee-471e-b6b3-823b1f9490f1", + "image_id": 206014, + "image_name": "16981.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 28.762, + 418.441, + 276.497, + 36.21800000000002 + ], + "priority": 3, + "parents": [ + 141849 + ], + "children": [ + 141836, + 141835 + ], + "area": 12035.200041999999, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 141835, + "strid": "b2bd61c7-2652-48ef-a78c-a023bc8ab315", + "image_id": 206014, + "image_name": "16981.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 25.811, + 491.394, + 1318.312, + 801.988 + ], + "priority": 4, + "parents": [ + 141829 + ], + "children": [], + "area": 12683.370534, + "iscrowd": 0, + "segmentation": [], + "text": "Biological data have benefited greatly from digital technologies in that they\nare now readily available in public databases. Consequently, a specific\nresearch problem is increasingly being addressed by multi-database search\nand data retrieval for obtaining the required facts about key functional and\nstructural entities. This concerns investigation ranging from gene or genome\nanalysis to protein structural analysis. For instance, a study of protein domain\narchitectures may require integrating data from nucleotide sequence and\nprotein databases [1], while an interspecific genomic study requires\nintegration of taxonomy and sequence data [2]. However, this data preparation\nstep is very often done in an unsystematic way on an individual basis, and can\nbe cumbersome when cross-referencing is involved. The need thus arises for a\nsystematic way of retrieving and integrating public information available for a\nspecific taxon. Here, we present TAGOPSIN (Taxonomy, Gene, Ontology,\nProtein, Structure INtegrated), a command line program written in Java whose\npurpose is to retrieve select data for a given organism from seven public\nbiological repositories [3-9] and assemble them in a data warehouse managed\nby PostgreSQL [10]." + }, + { + "id": 141836, + "strid": "59e318d0-3c16-4106-8738-fb5429f202b8", + "image_id": 206014, + "image_name": "16981.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 26.653, + 1322.824, + 1318.093, + 94.69499999999994 + ], + "priority": 5, + "parents": [ + 141829 + ], + "children": [], + "area": 35257.228072, + "iscrowd": 0, + "segmentation": [], + "text": "Keywords: comparative genomics, data integration, data retrieval, database,\nobject-oriented biology, open-source software" + }, + { + "id": 141830, + "strid": "4c53f019-7ad5-413b-a147-651eb39b2365", + "image_id": 206014, + "image_name": "16981.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 33.614, + 1465.2, + 225.545, + 36.565000000000055 + ], + "priority": 6, + "parents": [ + 141849 + ], + "children": [ + 141837, + 141840, + 141838 + ], + "area": 49251.2328, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 141837, + "strid": "f387bd88-741c-4492-a89d-1437038344ed", + "image_id": 206014, + "image_name": "16981.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 36.201, + 1534.439, + 1303.911, + 901.9150000000002 + ], + "priority": 7, + "parents": [ + 141830 + ], + "children": [], + "area": 55548.226239, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 141838, + "strid": "9847a457-f710-4420-849a-9fc2de49da5b", + "image_id": 206014, + "image_name": "16981.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 47.913, + 2491.787, + 1263.887, + 1489.1619999999998 + ], + "priority": 8, + "parents": [ + 141830 + ], + "children": [ + 141839 + ], + "area": 119388.99053099999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 141839, + "strid": "fad7f2a4-3c1a-4b96-a6b4-1353a65d4772", + "image_id": 206014, + "image_name": "16981.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 393.89, + 4072.785, + 912.582, + 39.899999999999636 + ], + "priority": 9, + "parents": [ + 141838 + ], + "children": [], + "area": 1604229.2836499999, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. Sequential steps in the functioning of TAGOPSIN" + }, + { + "id": 141840, + "strid": "c849388e-cc52-4c15-a40f-4ea41a4f06cf", + "image_id": 206014, + "image_name": "16981.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1384.778, + 428.484, + 1682.709, + 807.281 + ], + "priority": 10, + "parents": [ + 141830 + ], + "children": [ + 141841 + ], + "area": 593355.216552, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 141841, + "strid": "57e7bcb7-c3b6-4dd6-a07c-5f8fcd1b66ea", + "image_id": 206014, + "image_name": "16981.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1641.751, + 1264.63, + 1181.3530000000003, + 82.12599999999998 + ], + "priority": 11, + "parents": [ + 141840 + ], + "children": [], + "area": 2076207.56713, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2. Relational database schema representing schematically the data\nwarehouse built by TAGOPSIN" + }, + { + "id": 141831, + "strid": "a47e5493-f014-42da-ae16-c58d4d8f0664", + "image_id": 206014, + "image_name": "16981.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1375.031, + 1405.001, + 501.951, + 37.09500000000003 + ], + "priority": 12, + "parents": [ + 141849 + ], + "children": [ + 141842, + 141845, + 141844 + ], + "area": 1931919.930031, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 141842, + "strid": "25f62f32-5fab-44eb-99c9-e8cae3d17424", + "image_id": 206014, + "image_name": "16981.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1378.873, + 1486.401, + 1715.438, + 458.405 + ], + "priority": 13, + "parents": [ + 141831 + ], + "children": [], + "area": 2049558.206073, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 141844, + "strid": "96e9ea7d-aaad-4ec5-98ba-75b4f9f1d552", + "image_id": 206014, + "image_name": "16981.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1410.52, + 2057.329, + 1645.554, + 790.873 + ], + "priority": 14, + "parents": [ + 141831 + ], + "children": [ + 141843 + ], + "area": 2901903.70108, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 141843, + "strid": "4603c9c9-63e7-4169-b95a-5afb82e67736", + "image_id": 206014, + "image_name": "16981.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1815.481, + 2011.657, + 835.1119999999999, + 40.25800000000004 + ], + "priority": 15, + "parents": [ + 141844 + ], + "children": [], + "area": 3652125.062017, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1. Case study of the performance of TAGOPSIN" + }, + { + "id": 141845, + "strid": "768e22bf-b592-48c6-aacf-f442b206a059", + "image_id": 206014, + "image_name": "16981.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1377.937, + 2913.386, + 1715.21, + 293.86500000000024 + ], + "priority": 16, + "parents": [ + 141831 + ], + "children": [], + "area": 4014462.3646819997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 141832, + "strid": "af90360f-4300-40ef-a68f-1d76824bc20d", + "image_id": 206014, + "image_name": "16981.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1378.794, + 3299.951, + 307.46900000000005, + 35.17900000000009 + ], + "priority": 17, + "parents": [ + 141849 + ], + "children": [ + 141846 + ], + "area": 4549952.639094001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 141846, + "strid": "7bdd8791-7baf-46c9-8474-6e92a5fa768d", + "image_id": 206014, + "image_name": "16981.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1377.147, + 3371.624, + 1710.649, + 97.55200000000013 + ], + "priority": 18, + "parents": [ + 141832 + ], + "children": [], + "area": 4643221.876727999, + "iscrowd": 0, + "segmentation": [], + "text": "TAGOPSIN is released under the GNU General Public License. Source code, binary and\ndocumentation are available at ." + }, + { + "id": 141834, + "strid": "155d1c8d-97dc-4398-9a8c-2a4261b7e5d4", + "image_id": 206014, + "image_name": "16981.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1380.213, + 4025.497, + 133.81400000000008, + 27.804999999999836 + ], + "priority": 19, + "parents": [ + 141849 + ], + "children": [ + 141848 + ], + "area": 5556043.290860999, + "iscrowd": 0, + "segmentation": [], + "text": "FUNDING" + }, + { + "id": 141848, + "strid": "56277c9d-5fc7-41b4-9620-c1c2ceab82bd", + "image_id": 206014, + "image_name": "16981.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1382.461, + 4076.507, + 797.347, + 61.93700000000035 + ], + "priority": 20, + "parents": [ + 141834 + ], + "children": [], + "area": 5635611.943727, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 141833, + "strid": "67688fae-754d-4fda-aed3-fbfebd5c1430", + "image_id": 206014, + "image_name": "16981.png", + 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"children": [], + "area": 59807.958, + "iscrowd": 0, + "segmentation": [], + "text": "Pernicious Anemia in African Americans" + }, + { + "id": 6151, + "strid": "ee376b47-1026-4e48-b11f-fca8f590734c", + "image_id": 200748, + "image_name": "10783.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 626.077, + 175.137, + 2370.001, + 137.851 + ], + "priority": 2, + "parents": [ + 6160 + ], + "children": [], + "area": 109649.247549, + "iscrowd": 0, + "segmentation": [], + "text": "ANTONY IRUNGU BSc *, UCHE IKE BSc *, ANITA LWANGA MD ?.\n1.ROSS UNIVERSITY SCHOOL OF MEDICINE, 2. DEPARTMENT OF INTERNAL MEDICINE AT MOUNT SINAI HOSPITAL" + }, + { + "id": 6144, + "strid": "a320a94e-18e3-4723-9726-3feec497788f", + "image_id": 200748, + "image_name": "10783.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 520.224, + 392.586, + 223.13199999999995, + 48.41500000000002 + ], + "priority": 3, + "parents": [ + 6160 + ], + "children": [ + 6153 + ], + "area": 204232.65926400002, + "iscrowd": 0, + "segmentation": [], + "text": "Background" + }, + { + "id": 6153, + "strid": "5cb24526-decf-4203-ad79-4396962d0ee7", + "image_id": 200748, + "image_name": "10783.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 89.469, + 458.855, + 1078.982, + 589.931 + ], + "priority": 4, + "parents": [ + 6144 + ], + "children": [], + "area": 41053.297995, + "iscrowd": 0, + "segmentation": [], + "text": "Pernicious anemia, an autoimmune disorder characterized\nby the inability to absorb Vitamin B12, can be caused by\ndecreased production of intrinsic factor (IF), antibodies\nagainst parietal cells, antibodies against IF, chronic atrophic\ngastritis or a gastrectomy. Traditionally pernicious anemia\nwas thought to affect elderly individuals of Northern\nEuropean descent, however, a study done at Cook County\nHospital, in between 1931 to 1942, found that 93 out of\n1000 patients diagnosed with pernicious anemia were\nAfrican American. Other studies have also demonstrate that\npernicious anemia affects individuals of all ethnic groups." + }, + { + "id": 6146, + "strid": "3cb0ec14-9fcc-492f-b969-41c3901d891c", + "image_id": 200748, + "image_name": "10783.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 528.562, + 1072.311, + 198.67500000000007, + 46.59500000000003 + ], + "priority": 5, + "parents": [ + 6160 + ], + "children": [ + 6155 + ], + "area": 566782.8467819999, + "iscrowd": 0, + "segmentation": [], + "text": "Objectives" + }, + { + "id": 6155, + "strid": "08adcb35-7910-471a-8ba1-ee6b9bb277fc", + "image_id": 200748, + "image_name": "10783.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 80.696, + 1134.316, + 1063.631, + 162.28600000000006 + ], + "priority": 6, + "parents": [ + 6146 + ], + "children": [], + "area": 91534.763936, + "iscrowd": 0, + "segmentation": [], + "text": "Our objective is to encourage clinicians to consider\npernicious anemia, in their differential, as a cause of\nVitamin B 12 deficiency in individuals of African descent." + }, + { + "id": 6145, + "strid": "5de45999-e080-4e90-ab91-7c3d69751ee7", + "image_id": 200748, + "image_name": "10783.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 518.214, + 1343.479, + 223.87599999999998, + 42.89499999999998 + ], + "priority": 7, + "parents": [ + 6160 + ], + "children": [ + 6149, + 6150, + 6154, + 6156 + ], + "area": 696209.6265060001, + "iscrowd": 0, + "segmentation": [], + "text": "Case Report" + }, + { + "id": 6156, + "strid": "32d2d7df-4050-4a09-b7a2-4f7bb756fb26", + "image_id": 200748, + "image_name": "10783.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 89.023, + 1413.019, + 1086.639, + 904.1699999999998 + ], + "priority": 8, + "parents": [ + 6145 + ], + "children": [], + "area": 125791.190437, + "iscrowd": 0, + "segmentation": [], + "text": "Mr. H a 73 year old African American male presented with\ncomplaints of bilateral lower extremity weakness, dizziness\nthat occurred for 1 or 2 minutes after stood up, frequent falls\nand burning sensation from his mid shins to the bottom of\nhis feet. He symptoms had progressed over the last year. He\ndenied, nausea, vomiting, chills, fevers, loss of\nconsciousness, spinning sensation, or tinnitus. He had a past\nmedical history of hypertension and iron deficiency anemia.\nHe did not take medications, have allergies, drink alcohol,\nsmoke or use recreational drugs. His diet consisted mostly\nhot dogs because of limited finances. His vital signs were\nwithin normal limits except for positive orthostatic blood\npressure. His physical exam was unremarkable except for\nchronic non healing lesions on his lower legs, weakness in\nhis hip, knees and ankles, loss of conscious proprioception,\nloss of sensation in his feet, ataxic gait, and a positive\nBabinski sign." + }, + { + "id": 6154, + "strid": "350ccaee-23a5-4ba9-a646-1d4b52b965a4", + "image_id": 200748, + "image_name": "10783.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1247.401, + 406.222, + 1100.9130000000002, + 271.9390000000001 + ], + "priority": 9, + "parents": [ + 6145 + ], + "children": [], + "area": 506721.729022, + "iscrowd": 0, + "segmentation": [], + "text": "His hemoglobin was 7.6 mg/dL, his MCV was 114 um 3 ,\nhis Vitamin B 12 was < 50 pb/mL, while intrinsic factor was\npositive. His brain and neck MRI were negative for signs of\nmyelopathy. He was referred to a Gastroenterologist for an\nesophagogastroduodenoscopy but was lost to follow up." + }, + { + "id": 6149, + "strid": "e4988da2-b1ab-4791-b406-3a76baddb964", + "image_id": 200748, + "image_name": "10783.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1318.894, + 701.758, + 958.258, + 586.9559999999999 + ], + "priority": 10, + "parents": [ + 6145 + ], + "children": [], + "area": 925544.415652, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 6150, + "strid": "105c307f-51d3-4d80-b077-29ef494b63a4", + "image_id": 200748, + "image_name": "10783.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1237.839, + 1326.252, + 1121.8779999999997, + 539.7539999999999 + ], + "priority": 11, + "parents": [ + 6145 + ], + "children": [], + "area": 1641686.4494279998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 6148, + "strid": "3c81d4bb-a7d6-40c2-a3e1-78be7c15ee53", + "image_id": 200748, + "image_name": "10783.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1706.574, + 1906.56, + 194.721, + 40.64599999999996 + ], + "priority": 12, + "parents": [ + 6160 + ], + "children": [ + 6159, + 6157 + ], + "area": 3253685.72544, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion" + }, + { + "id": 6157, + "strid": "b316882d-a275-4946-96a6-904ede4bccbf", + "image_id": 200748, + "image_name": "10783.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1259.096, + 1962.589, + 1078.7490000000003, + 371.1970000000001 + ], + "priority": 13, + "parents": [ + 6148 + ], + "children": [], + "area": 2471087.9595439998, + "iscrowd": 0, + "segmentation": [], + "text": "In Caucasians, the average age of onset of pernicious\nanemia in is in the 60s, , while in those of African descent it\nis in the 50s, and has a female predominance. In our patient,\nand most individuals of African descent, pernicious anemia\nis caused by antibodies against IF, rather than antibodies\nagainst parietal cells, as is the case in individuals of\nEuropean descent." + }, + { + "id": 6159, + "strid": "a3948d01-9615-49b8-9738-ff849b8ff4f8", + "image_id": 200748, + "image_name": "10783.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2423.908, + 417.434, + 1067.9940000000001, + 1004.99 + ], + "priority": 14, + "parents": [ + 6148 + ], + "children": [], + "area": 1011821.612072, + "iscrowd": 0, + "segmentation": [], + "text": "African Americans with pernicious anemia demonstrate a\nlower incidence of anti-parietal cell antibodies with the\npresence of IF antibodies or absence anti-parietal cell\nantibodies compared to individuals of European descent.\nFailure to recognize and treat pernicious anemia can lead to\nirreversible neurological deficits and disability. One tragic\ncase, in the literature we reviewed, is that of a 29 year\nfemale whose macrocytosis and paresthesia were ignored\nfor 7 months. A diagnosis of pernicious anemia was\neventually made, after she developed subacute combined\ndegeneration. This was most likely due to outdated\ninformation regarding the racial incidence and age group\nthat is susceptible to pernicious anemia. In accurate\ninformation regarding pernicious anemia may cause\nclinicians to overlook this diagnosis in patients of African\ndescent, particularly young adults. Pernicious anemia is\ntreated with 1000 ug of intramuscular Vitamin B12 daily\nfor 7 days, then 1000 ug weekly for 4 weeks, then 1000 ug\nmonthly for life." + }, + { + "id": 6147, + "strid": "4efb0b4e-a6f6-43a9-b74f-b4ec90ca9b6f", + "image_id": 200748, + "image_name": "10783.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2852.197, + 1439.12, + 235.10199999999986, + 44.31600000000003 + ], + "priority": 15, + "parents": [ + 6160 + ], + "children": [ + 6158 + ], + "area": 4104653.74664, + "iscrowd": 0, + "segmentation": [], + "text": "Bibliography" + }, + { + "id": 6158, + "strid": "7b6f614e-2093-4a37-a5c9-a22fa6d8389d", + "image_id": 200748, + "image_name": "10783.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2425.204, + 1511.246, + 1089.3740000000003, + 705.9989999999998 + ], + "priority": 16, + "parents": [ + 6147 + ], + "children": [], + "area": 3665079.8441840005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 133267, + "strid": "910d1b5c-70ec-4642-aa89-0ec0b163f6cc", + "image_id": 205672, + "image_name": "15564.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 46.36, + 269.47, + 422.4, + 107.26999999999998 + ], + "priority": -1, + "parents": [], + "children": [ + 133244, + 133239, + 133241, + 133240, + 133243, + 133245, + 133242, + 133238 + ], + "area": 12492.629200000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 133238, + "strid": "e44fcac0-1827-4de3-82e2-11d7622088e8", + "image_id": 205672, + "image_name": "15564.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 220.895, + 482.474, + 2841.496, + 195.334 + ], + "priority": 1, + "parents": [ + 133267 + ], + "children": [], + "area": 106576.09423, + "iscrowd": 0, + "segmentation": [], + "text": "Sub-millimetre T, mapping using inversion recovery EPI and\nits application to cortical depth-dependent fMRI at 7 Tesla." + }, + { + "id": 133239, + "strid": "bff56ea4-d4a7-48ec-8ad5-4c1af652588d", + "image_id": 205672, + "image_name": "15564.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 241.908, + 767.549, + 2018.098, + 106.07899999999995 + ], + "priority": 2, + "parents": [ + 133267 + ], + "children": [], + "area": 185676.24349199998, + "iscrowd": 0, + "segmentation": [], + "text": "Sriranga Kashyap, Dimo Ivanov, Martin Havli¢ek, Benedikt A. Poser, Kamil Uludag\n\nDepartment of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, The Netherlands" + }, + { + "id": 133240, + "strid": "ed665c04-f970-468b-9d08-3714da5bc33a", + "image_id": 205672, + "image_name": "15564.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 262.157, + 945.513, + 259.74899999999997, + 35.90999999999997 + ], + "priority": 3, + "parents": [ + 133267 + ], + "children": [ + 133246 + ], + "area": 247872.85154099998, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 133246, + "strid": "34ebcae9-34fe-428f-b4bb-63b053ad2dbb", + "image_id": 205672, + "image_name": "15564.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 262.982, + 1012.317, + 1284.891, + 578.8820000000001 + ], + "priority": 4, + "parents": [ + 133240 + ], + "children": [], + "area": 266221.149294, + "iscrowd": 0, + "segmentation": [], + "text": "Laminar functional MRI has the potential to unravel the mesoscopic circuitry\nunderlying cognitive processes. In order to determine laminar information from the\nfunctional data, cortical depths are usually determined on an anatomical image, which\nhas to be co-registered to the distorted-corrected functional data. The standard\napproaches for distortion correction of the EPI data utilise algorithm such as FSL-\nTOPUP\"]. However, such methods reduce the laminar information due to smoothing\nand interpolation. In addition to such distortion effects, sub-optimal registration to the\nanatomy might lead to erroneous classification of depths. Here, we propose to improve\non the aforementioned standard pipeline by acquiring a distortion-matched anatomical\nimage that provides accurate anatomical registration and eliminate the necessity to\nperform distortion correction on the functional data. Finally, we adopted a spatial\nregression algorithms to further improve the determination of the laminar fMRI time\ncourses." + }, + { + "id": 133243, + "strid": "14a0f500-720f-4d2d-acdb-5731891583e6", + "image_id": 205672, + "image_name": "15564.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 266.378, + 1645.815, + 172.69099999999997, + 33.531999999999925 + ], + "priority": 5, + "parents": [ + 133267 + ], + "children": [ + 133253, + 133252, + 133247, + 133249, + 133248, + 133254 + ], + "area": 438408.90807, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 133247, + "strid": "bfe74d57-8aea-4221-a2ec-bec8ee3dc1b7", + "image_id": 205672, + "image_name": "15564.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 260.566, + 1709.402, + 1287.982, + 472.2420000000002 + ], + "priority": 6, + "parents": [ + 133243 + ], + "children": [], + "area": 445412.04153199994, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 133248, + "strid": "5601d8ec-6469-4579-9546-817dcae787ac", + "image_id": 205672, + "image_name": "15564.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 335.12, + 2245.564, + 554.572, + 493.078 + ], + "priority": 7, + "parents": [ + 133243 + ], + "children": [ + 133250 + ], + "area": 752533.40768, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 133250, + "strid": "5b9af693-dc37-4863-a950-a21b18667c04", + "image_id": 205672, + "image_name": "15564.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 345.899, + 2776.66, + 504.077, + 69.1260000000002 + ], + "priority": 8, + "parents": [ + 133248 + ], + "children": [], + "area": 960443.9173399999, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1: Representative slice at each of\nthe thirty inversion times" + }, + { + "id": 133249, + "strid": "225a80be-298a-4b96-9a82-ba821ce1db41", + "image_id": 205672, + "image_name": "15564.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 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[] + }, + { + "id": 133253, + "strid": "c9762e0e-644d-4b17-b563-0a40c70c0a2e", + "image_id": 205672, + "image_name": "15564.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 367.773, + 3400.645, + 375.446, + 618.2440000000001 + ], + "priority": 12, + "parents": [ + 133243 + ], + "children": [ + 133255 + ], + "area": 1250665.413585, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 133255, + "strid": "c75f2be2-f2ef-4d87-84db-3db697a4183a", + "image_id": 205672, + "image_name": "15564.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 298.855, + 4040.859, + 530.888, + 148.30899999999974 + ], + "priority": 13, + "parents": [ + 133253 + ], + "children": [], + "area": 1207630.916445, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3: The interpolation approach:\nOutline of GM-WM and CSF-GM\nboundaries overlaid on functional ROI\n(Top), cortical depth definitions (Bottom)." + }, + { + "id": 133254, + "strid": "e044a99d-f0b5-4028-bd2b-aace28db6613", + "image_id": 205672, + "image_name": "15564.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1030.791, + 3394.862, + 456.84799999999996, + 615.5830000000001 + ], + "priority": 14, + "parents": [ + 133243 + ], + "children": [ + 133256 + ], + "area": 3499393.1958419997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 133256, + "strid": "ac1a7d8c-ecc0-41fd-8dc1-cf5a499a8366", + "image_id": 205672, + "image_name": "15564.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 989.221, + 4041.194, + 530.1770000000001, + 147.99400000000014 + ], + "priority": 15, + "parents": [ + 133254 + ], + "children": [], + "area": 3997633.969874, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 4: The Spatial GLM approach:\nLaminar model in an illustrated GM RO!\n(Top), Model of laminar contributions in\neach voxel of the GM ROI (Bottom)." + }, + { + "id": 133241, + "strid": "b731708d-30d9-417b-a899-13d396d91d07", + "image_id": 205672, + "image_name": "15564.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1700.325, + 930.008, + 195.26199999999994, + 40.67999999999995 + ], + "priority": 16, + "parents": [ + 133267 + ], + "children": [ + 133257 + ], + "area": 1581315.8526, + "iscrowd": 0, + "segmentation": [], + "text": "Objective" + }, + { + "id": 133257, + "strid": "8dd43c1b-ac81-475c-95a7-80ba45e3867c", + "image_id": 205672, + "image_name": "15564.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1700.84, + 994.028, + 1343.479, + 267.0820000000001 + ], + "priority": 17, + "parents": [ + 133241 + ], + "children": [], + "area": 1690682.5835199999, + "iscrowd": 0, + "segmentation": [], + "text": "The present study builds upon previous work [I] to acquire sub-millimetre distortion-\nmatched quantitative T, image using inversion-recovery EPI (IR-EPI) to define cortical-\ndepths to sample the laminar signal using both the interpolation and the Spatial GLM\napproaches. Therefore, the overall objective is to investigate the effect of possible\nimprovements to both the acquisition and analysis methods on the sampled laminar\ninformation from high-field fMRI data." + }, + { + "id": 133242, + "strid": "26a49e2e-5f3f-4a94-9548-5b54e4834519", + "image_id": 205672, + "image_name": "15564.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1701.36, + 1349.424, + 466.11199999999985, + 32.702 + ], + "priority": 18, + "parents": [ + 133267 + ], + "children": [ + 133259, + 133262, + 133258, + 133260, + 133263 + ], + "area": 2295856.01664, + "iscrowd": 0, + "segmentation": [], + "text": "Results and Discussion" + }, + { + "id": 133258, + "strid": "98e0ab68-5510-4d56-b070-d45d717d0fd3", + "image_id": 205672, + "image_name": "15564.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1699.247, + 1412.903, + 1331.802, + 215.192 + ], + "priority": 19, + "parents": [ + 133242 + ], + "children": [], + "area": 2400871.184041, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 133259, + "strid": "19600aa7-8aac-4238-92ae-12a5d28acae2", + "image_id": 205672, + "image_name": "15564.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1852.026, + 1600.196, + 491.3900000000001, + 276.14300000000003 + ], + "priority": 20, + "parents": [ + 133242 + ], + "children": [ + 133261 + ], + "area": 2963604.597096, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 133261, + "strid": "416e66b7-a0f9-4aec-b9b3-4a28e92aaeb3", + "image_id": 205672, + "image_name": "15564.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1724.954, + 1879.319, + 1303.3, + 187.84000000000015 + ], + "priority": 21, + "parents": [ + 133259 + ], + "children": [], + "area": 3241738.826326, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 5: Comparison of registration accuracy between the two approaches. Left: Contours of the co-\nregistered MP2RAGE overlaid on the mean distortion-corrected EPI image shows local misregistrations\nin regions most susceptible to distortions (zoom). Right: Contours of the co-registered IR-EPI qT, overlaid\non the mean EPI image shows the superior co-registration (right) even in regions most susceptible to\ndistortions (zoom)." + }, + { + "id": 133260, + "strid": "a757dde3-104f-40a4-b028-9b1e1e5c9ab1", + "image_id": 205672, + "image_name": "15564.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2402.316, + 1603.146, + 495.2840000000001, + 271.826 + ], + "priority": 22, + "parents": [ + 133242 + ], + "children": [], + "area": 3851263.2861359995, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 133262, + "strid": "439e00f4-dad7-4f16-8dba-a9e940e2198d", + "image_id": 205672, + "image_name": "15564.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1699.441, + 2078.848, + 1345.9260000000002, + 493.3710000000001 + ], + "priority": 23, + "parents": [ + 133242 + ], + "children": [], + "area": 3532879.523968, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 133263, + "strid": "32a11b7c-674e-441b-a777-199477f96ac4", + "image_id": 205672, + "image_name": "15564.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1828.803, + 2580.514, + 1071.611, + 785.8690000000001 + ], + "priority": 24, + "parents": [ + 133242 + ], + "children": [ + 133264 + ], + "area": 4719251.7447420005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 133264, + "strid": "ed92cc8f-02a6-446d-be53-8084e2c1fed6", + "image_id": 205672, + "image_name": "15564.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1694.609, + 3363.459, + 1363.127, + 229.721 + ], + "priority": 25, + "parents": [ + 133263 + ], + "children": [], + "area": 5699747.892530999, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 6: Timecourses obtained from an ROI using the different analysis pipelines and sampling approaches.\n(a) & (b): Comparison between IR-EPI and TOPUP analysis pipelines with laminae sampled using\nInterpolation method. (a) & (c) Comparison between Interpoilation and Spatial GLM laminar sampling\napproaches using the IR-EPI analysis pipeline (Note: 4 (out of 8) cortical-depths presented for clarity.) (d)\nComparison of cortical depth profiles of the positive BOLD sampled using Interpolation and Spatial GLM\napproaches in the IR-EPI pipeline." + }, + { + "id": 133244, + "strid": "887f269d-b2b6-4732-9016-ee768bc6edb7", + "image_id": 205672, + "image_name": "15564.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1701.34, + 3641.58, + 220.68599999999992, + 32.62699999999995 + ], + "priority": 26, + "parents": [ + 133267 + ], + "children": [ + 133265 + ], + "area": 6195565.7172, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion" + }, + { + "id": 133265, + "strid": "a3e32916-3797-41cc-8845-3e4f7e73d962", + "image_id": 205672, + "image_name": "15564.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1698.516, + 3681.675, + 1342.5949999999998, + 162.962 + ], + "priority": 27, + "parents": [ + 133244 + ], + "children": [], + "area": 6253383.894300001, + "iscrowd": 0, + "segmentation": [], + "text": "There is a substantive benefit of using IR-EPI to acquire distortion-matched anatomy in\nhigh-resolution fMRI studies, specifically, laminar fMRI studies. Simulations and\npreliminary results indicate a benefit of using Spatial GLM approach over the Interpolation\napproach to achieve a cleaner decomposition of the laminar signals." + }, + { + "id": 133245, + "strid": "c04fb29d-4e21-469f-9044-03a949e3450e", + "image_id": 205672, + "image_name": "15564.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1697.617, + 3910.794, + 228.0429999999999, + 34.315000000000055 + ], + "priority": 28, + "parents": [ + 133267 + ], + "children": [ + 133266 + ], + "area": 6639030.377897999, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 133266, + "strid": "5b423070-8cf1-4d13-9f11-8fd66b0700d8", + "image_id": 205672, + "image_name": "15564.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1694.887, + 3956.351, + 1346.6360000000002, + 283.0300000000002 + ], + "priority": 29, + "parents": [ + 133245 + ], + "children": [], + "area": 6705567.877337, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 113327, + "strid": "ddbf6b4a-9961-4358-9120-b963bfaea579", + "image_id": 204896, + "image_name": "13460.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 74.11, + 162.38, + 214.37, + 243.94 + ], + "priority": -1, + "parents": [], + "children": [ + 113312, + 113309, + 113315, + 113320, + 113326, + 113323, + 113322, + 113325, + 113308, + 113313, + 113310, + 113321, + 113314, + 113324 + ], + "area": 12033.9818, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 113308, + "strid": "a8158284-699c-499b-8335-d556d477a7eb", + "image_id": 204896, + "image_name": "13460.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 498.071, + 145.625, + 2770.863, + 239.16899999999998 + ], + "priority": 1, + "parents": [ + 113327 + ], + "children": [], + "area": 72531.58937500001, + "iscrowd": 0, + "segmentation": [], + "text": "Data flow within the Multiscale Genomics Virtual\nResearch Environment for 3D Genome Analysis" + }, + { + "id": 113309, + "strid": "1d8102a0-036a-4b3b-a742-b5d86ebcfe2d", + "image_id": 204896, + "image_name": "13460.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 136.833, + 484.688, + 1499.038, + 141.39800000000002 + ], + "priority": 2, + "parents": [ + 113327 + ], + "children": [], + "area": 66321.313104, + "iscrowd": 0, + "segmentation": [], + "text": "Mark D. McDowall*?, Pablo Acera?, Reham Fatima?, Andrew Yates? and the Multiscale Genomics Consortium\n\n1. European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome\nGenome Campus, Hinxton, Cambridge, CB10 1SD, United Kingdom" + }, + { + "id": 113310, + "strid": "07d2880a-8dc5-4c5f-b695-3ae634d2d04b", + "image_id": 204896, + "image_name": "13460.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 138.19, + 645.337, + 302.279, + 59.57299999999998 + ], + "priority": 3, + "parents": [ + 113327 + ], + "children": [ + 113311 + ], + "area": 89179.12002999999, + "iscrowd": 0, + "segmentation": [], + "text": "Summary" + }, + { + "id": 113311, + "strid": "b93c6c54-f98d-407e-8da3-dc113a1138c3", + "image_id": 204896, + "image_name": "13460.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 133.613, + 710.549, + 1540.406, + 443.327 + ], + "priority": 4, + "parents": [ + 113310 + ], + "children": [], + "area": 94938.583537, + "iscrowd": 0, + "segmentation": [], + "text": "The Multiscale Genomics Virtual Research Environment (VRE) is a\nresource to investigate the structure of chromosomes by integrating\nmultiple sources of biological knowledge concerning DNA proximity,\nlocations of genes, expression, nucleosomes, promoter regions and\nmethylation sites. The VRE is open to the scientific community and\nsupports experimental data upload, analysis and visualisation using\ntools, such as TADbit, nucleR and pyDock. APIs facilitate tool\nintegration and data management." + }, + { + "id": 113312, + "strid": "7e928383-0f08-4fb8-aeec-0a07e2c3f08c", + "image_id": 204896, + "image_name": "13460.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 353.954, + 1285.867, + 345.059, + 58.50700000000006 + ], + "priority": 5, + "parents": [ + 113327 + ], + "children": [ + 113316 + ], + "area": 455137.768118, + "iscrowd": 0, + "segmentation": [], + "text": "Import Data" + }, + { + "id": 113316, + "strid": "fe006da8-5457-43a5-8078-774e4aec581f", + "image_id": 204896, + "image_name": "13460.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 194.166, + 1390.717, + 502.944, + 328.36900000000014 + ], + "priority": 6, + "parents": [ + 113312 + ], + "children": [], + "area": 270029.957022, + "iscrowd": 0, + "segmentation": [], + "text": "Data can be imported\neither from an\nexternal resource\n(ENA, PDB, etc) or\nexperimental data the\nuser has generated" + }, + { + "id": 113313, + "strid": "9369e487-6498-4af5-a067-b7108a2f96bc", + "image_id": 204896, + "image_name": "13460.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1333.13, + 1219.764, + 332.5129999999999, + 174.6690000000001 + ], + "priority": 7, + "parents": [ + 113327 + ], + "children": [ + 113319 + ], + "area": 1626103.98132, + "iscrowd": 0, + "segmentation": [], + "text": "Virtual\nResearch\nEnvironment" + }, + { + "id": 113319, + "strid": "8fb9bc3e-c3d7-474c-8d35-765fcddf664f", + "image_id": 204896, + "image_name": "13460.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1172.078, + 1411.457, + 1209.6190000000001, + 333.624 + ], + "priority": 8, + "parents": [ + 113313 + ], + "children": [], + "area": 1654337.6976460002, + "iscrowd": 0, + "segmentation": [], + "text": "The VRE is the hub. From here users can upload their\ndata, or import published data from archives. Once\nthe user has the data they are able to run relevant\nanalysis pipelines. The VRE also manages the logging\nof the results files within the data management\nsystem." + }, + { + "id": 113322, + "strid": "ea7f2efb-d643-4773-b698-a5fc2f490c0e", + "image_id": 204896, + "image_name": "13460.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1823.217, + 502.169, + 586.56, + 488.96799999999996 + ], + "priority": 9, + "parents": [ + 113327 + ], + "children": [], + "area": 915563.057673, + "iscrowd": 0, + "segmentation": [], + "text": "Visualisation\n\nThe VRE also hosts the\nresults files so that they\ncan be visualised by tools\nsuch as JBrowse, TADkit\nand NGLviewer that have\nbeen integrated into the\nVRE." + }, + { + "id": 113321, + "strid": "d989e08b-44ca-47a7-afb7-5e5f0607762c", + "image_id": 204896, + "image_name": "13460.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2437.687, + 565.101, + 724.0079999999998, + 556.457 + ], + "priority": 10, + "parents": [ + 113327 + ], + "children": [], + "area": 1377539.361387, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 113323, + "strid": "cddedc82-1062-4547-bc6b-186954b0a202", + "image_id": 204896, + "image_name": "13460.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1751.95, + 1934.888, + 1359.291, + 982.7669999999998 + ], + "priority": 11, + "parents": [ + 113327 + ], + "children": [], + "area": 3389827.0316, + "iscrowd": 0, + "segmentation": [], + "text": "Data Management ,\n\n4\nFiles can be held in different locations within the VRE\n(currently the Barcelona Supercomputing Centre and EMBL-\nEBI). Tracking file locations is crucial so that pipeline\nexecution is performed on compute clusters close to the\nlocation of the data for computational efficiency and to\nminimise transfer. The Data Management API handles the\ntracking of files, data types and matching metadata to\ndescribe the information within the file, including how it was\ngenerated and the source files that were required for its\ncreation. Clear descriptions about how experimental data\nwas generated and analysed facilitate publication\nreproducibility and helps when submitting to data archives.\n\nRESTful APIs allow access from multiple servers for analysis\nand visualisation, while indexing and storage optimisations\ncreate a seamless experience when searching through the" + }, + { + "id": 113324, + "strid": "2169ad4e-1e93-499a-8c4b-48591353dca1", + "image_id": 204896, + "image_name": "13460.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1753.3, + 3009.468, + 1395.305, + 489.7080000000001 + ], + "priority": 12, + "parents": [ + 113327 + ], + "children": [], + "area": 5276500.244399999, + "iscrowd": 0, + "segmentation": [], + "text": "Tool API\n\nThe Tools API has been developed to wrap individual tools ina\ncommon format. It provides a common interface to the VRE\nallowing the web interface to help the user to match the\nrelevant input data and tool. The Tool API also provides the\ninternal wrappings to make it easier to run tools within a high\nperformance computing environment, such as the BSC or the\nEMBASSY cloud at the EMBL-EBI." + }, + { + "id": 113314, + "strid": "ce767bcf-6ede-4419-8c02-01806f7ce28a", + "image_id": 204896, + "image_name": "13460.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 313.775, + 2189.852, + 468.01699999999994, + 123.16199999999981 + ], + "priority": 13, + "parents": [ + 113327 + ], + "children": [ + 113317 + ], + "area": 687120.8113, + "iscrowd": 0, + "segmentation": [], + "text": "Data Processing\nPipeline" + }, + { + "id": 113317, + "strid": "5b4c1d73-399e-471e-8904-f7419fd7e5ed", + "image_id": 204896, + "image_name": "13460.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 165.152, + 2353.122, + 1043.584, + 330.96500000000015 + ], + "priority": 14, + "parents": [ + 113314 + ], + "children": [], + "area": 388622.80454399996, + "iscrowd": 0, + "segmentation": [], + "text": "A tool, or a series of connected tools, that can\nbe run by the VRE to process selected input\ndata. Each tool uses the Tool API to wrap an\napplication so that it can run within the\nCOMPSs infrastructure and communicate the\nresults back to the MuG VRE." + }, + { + "id": 113320, + "strid": "044628ec-7907-45ef-bbb5-8f487c10f163", + "image_id": 204896, + "image_name": "13460.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 211.544, + 2905.519, + 1332.444, + 643.4839999999999 + ], + "priority": 15, + "parents": [ + 113327 + ], + "children": [], + "area": 614645.111336, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 113315, + "strid": "9b76e4d0-fef5-4aa1-a463-6b529448c4f6", + "image_id": 204896, + "image_name": "13460.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 391.443, + 4008.7, + 271.45900000000006, + 121.20499999999993 + ], + "priority": 16, + "parents": [ + 113327 + ], + "children": [ + 113318 + ], + "area": 1569177.5540999998, + "iscrowd": 0, + "segmentation": [], + "text": "Analysed\nResults" + }, + { + "id": 113318, + "strid": "3305b01c-8397-4083-b1d9-f8c492c82a81", + "image_id": 204896, + "image_name": "13460.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 136.177, + 4184.47, + 714.81, + 166.83200000000033 + ], + "priority": 17, + "parents": [ + 113315 + ], + "children": [], + "area": 569828.57119, + "iscrowd": 0, + "segmentation": [], + "text": "Results are consolidated and\nreturned to the VRE where they\nare logged with DM API." + }, + { + "id": 113325, + "strid": "a02d0210-ef5d-4ae8-b808-214299c4466a", + "image_id": 204896, + "image_name": "13460.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1746.721, + 3631.308, + 1415.815, + 606.7709999999997 + ], + "priority": 18, + "parents": [ + 113327 + ], + "children": [], + "area": 6342881.941068, + "iscrowd": 0, + "segmentation": [], + "text": "Documentation\n\nAll software, both APIs and pipelines, that are being developed\nhave been documented and made publicly via the\nReadTheDocs.org service. This is automatically rebuilt every\ntime code is committed to the GitHub repository.\n\nhttps://multiscale-genomics.readthedocs.io\n\nHelp documentation has also been provided for how to use the\nMuG VRE portal" + }, + { + "id": 113326, + "strid": "52e6232d-6307-4b80-afa0-f0aab8547574", + "image_id": 204896, + "image_name": "13460.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1732.822, + 4269.74, + 1425.5360000000003, + 219.86300000000028 + ], + "priority": 19, + "parents": [ + 113327 + ], + "children": [], + "area": 7398699.406279999, + "iscrowd": 0, + "segmentation": [], + "text": "Badia. a ere , Diaz, C., Ejarque, J., Lezzi, D., Lordan, F., Ramon-Cortes, C., and Sirvent, R. (2015). COMP Superscalar, an interoperable programming framework.\njoftwareX 3-4, 32- ;\n\nLordan, F., Tejedor, E., Ejarque, J., Rafanell, R., Alvarez, J., Marozzo, F., Lezzi, D., Sirvent, R., Talia, D., and Badia, R.M. (2014). ServiceSs: An Interoperable Programming\nFramework for the Cloud. J Grid Computing 12, 67-91.\n\nRose, A.S., and Hildebrand, P.W. (2015). NGL Viewer: a web application for molecular visualization. Nucleic Acids Res 43, W576-W579.\n\nRose, A.S., Bradley, A.R., Valasatava, Y., Duarte, J.M., Prli¢, A., and Rose, P.W. (2016). Web-based Molecular Graphics for Large Complexes. In Proceedings of the 21st\nInternational Conference on Web3D Technology, (New York, NY, USA: ACM), pp. 185-186.\n\nSerra, F., Bau, D., Goodstadt, M., Castillo, D., Filion, G.J., and Marti-Renom, M.A. (2017). Automatic analysis and 3D-modelling of Hi-C data using TADbit reveals structural\nfeatures of the fly chromatin colors. PLOS Computational Biology 13, e1005665\n\nSkinner, M.E., Uzilov, A.V., Stein, L-D., Mungall, C.J., and Holmes, I.H. (2009). JBrowse: a next-generation genome browser., JBrowse: A next-generation genome browser.\nGenome Res 19, 19, 1630, 1630-1638.\n\nTejedor, E., Becerra, Y., Alomar, G., Queralt, A., Badia, R.M., Torres, J., Cortes, T., and Labarta, J. (2017). PyCOMPSs: Parallel computational workflows in Python. 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Mawexbeyenchovin Ba 12-820." + }, + { + "id": 18839, + "strid": "77ce0098-e6a4-45f5-b573-c8098426c594", + "image_id": 201244, + "image_name": "116806.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 410.409, + 963.916, + 59.07499999999999, + 48.44200000000001 + ], + "priority": 34, + "parents": [ + 18866 + ], + "children": [], + "area": 395599.801644, + "iscrowd": 0, + "segmentation": [], + "text": "Pash" + }, + { + "id": 70660, + "strid": "91a39d47-37a8-47b7-abb2-ed6199b65a6e", + "image_id": 203255, + "image_name": "119949.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 547.69, + 120.88, + 264.77, + 165.48000000000002 + ], + "priority": -1, + "parents": [], + "children": [ + 70635, + 70633, + 70639, + 70637, + 70638, + 70634, + 70636 + ], + "area": 66204.7672, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 70633, + "strid": "934df808-bdf4-40ed-a24f-1027edfd841d", + "image_id": 203255, + "image_name": "119949.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 880.615, + 201.436, + 3218.6640000000007, + 107.49500000000003 + ], + "priority": 1, + "parents": [ + 70660 + ], + "children": [], + "area": 177387.56314, + "iscrowd": 0, + "segmentation": [], + "text": "A Centralized Smart Platform for Open Sharing of iPS Cell Information" + }, + { + "id": 70634, + "strid": "d19319cd-2941-4258-b4a6-38897a0ba90f", + "image_id": 203255, + "image_name": "119949.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 777.623, + 315.818, + 3424.77, + 116.81399999999996 + ], + "priority": 2, + "parents": [ + 70660 + ], + "children": [], + "area": 245587.34061400002, + "iscrowd": 0, + "segmentation": [], + "text": "Richard V. Pearse’, Chris Napolitano?, Matthew Brush?, Tenille Johnson+, Melissa Haendel?, Sophia Cheng’, Scott Noggle2, Scott Lipnick?, Daniela Bourges-Waldegg?\n1Harvard Catalyst, Clinical and Translational Sciences Department, Harvard Medical School, New York Stem Cell Foundation, ?Oregon Health and Sciences University" + }, + { + "id": 70635, + "strid": "775ecbb3-5e76-4037-a2d7-42c097a72aa4", + "image_id": 203255, + "image_name": "119949.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 791.66, + 791.823, + 353.3850000000001, + 76.75999999999999 + ], + "priority": 3, + "parents": [ + 70660 + ], + "children": [ + 70640, + 70641 + ], + "area": 626854.59618, + "iscrowd": 0, + "segmentation": [], + "text": "Abstract" + }, + { + "id": 70640, + "strid": "ead6657f-1ca2-48c7-822d-3a8998e9b4e6", + "image_id": 203255, + "image_name": "119949.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 263.518, + 880.409, + 1407.437, + 794.003 + ], + "priority": 4, + "parents": [ + 70635 + ], + "children": [], + "area": 232003.61886199997, + "iscrowd": 0, + "segmentation": [], + "text": "With rapidly advancing technologies, allowing researchers to create collections of stem cell lines faster\nthan ever, it’s become increasingly difficult to keep abreast of the lines that have already been developed.\nWhile proposals are swimming in for funding the development of thousands of new lines, it’s entirely\nunclear which of these are proposing to generate lines that have already been developed. We propose\nthe creation of a centralized “point-of-truth” database that would serve as an authoritative description\nof all stem cell lines that are available for potential sharing. A qualified platform should: |) allow\nresearchers to edit and update their own information, 2) be openly discoverable by traditional internet\nsearch engines, 3) publish information as linked open data (i.e. xml, rdf) to be compatible with third\nparty applications such as Pubmed “linkouts” that automatically link journal articles to relevant\nresources contained therein, 4) be open source and open access to allow individual institutions to\ncustomize and modify functionality as required, 5) be driven by a centralized Ontology to force\nconsistent and accurate description of stem cells. We are using the eagle-i research resource-sharing\nplatform (which meets the above criteria) to support this effort. We've started with a collection of iPS\nand ES cells from the Harvard Stem Cell Institute, from individual researchers across Harvard\nUniversity, and from the New York Stem Cell Foundation. We have also used the eagle-i platform to\ncoordinate iPS cell and ES cell ontological descriptions with input from researcher who are actively\ngenerating stem cells from patients. Here we demonstrate the features of the eagle-i platform that are\nrelevant to the stem cell information sharing project, the ontology that allows accurate description of\nstem cells, and the future developments that will lay the groundwork for building the single “point-of-\ntruth” source for stem cell information." + }, + { + "id": 70641, + "strid": "c80be601-f36e-4213-b4e2-a5deb145c7f1", + "image_id": 203255, + "image_name": "119949.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 509.17, + 1807.417, + 1126.38, + 155.933 + ], + "priority": 5, + "parents": [ + 70635 + ], + "children": [], + "area": 920282.51389, + "iscrowd": 0, + "segmentation": [], + "text": "If I’m not at my poster (or even if | am!): scan the QR code to\nwatch a 2.5 minute introductory video describing the eagle-i\nproject, it’s history, goals, and value to researchers like you." + }, + { + "id": 70636, + "strid": "fe3c65fe-3e6e-4ed8-9b46-90309709956e", + "image_id": 203255, + "image_name": "119949.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 613.214, + 2041.407, + 690.8839999999999, + 100.77499999999986 + ], + "priority": 6, + "parents": [ + 70660 + ], + "children": [ + 70643, + 70642 + ], + "area": 1251819.352098, + "iscrowd": 0, + "segmentation": [], + "text": "Linked Open Data" + }, + { + "id": 70643, + "strid": "5c985a09-55f4-44c3-bf3e-376c016fb2ee", + "image_id": 203255, + "image_name": "119949.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 254.187, + 2124.554, + 1404.9480000000003, + 1056.971 + ], + "priority": 7, + "parents": [ + 70636 + ], + "children": [], + "area": 540034.007598, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 70642, + "strid": "cf3f6385-52c2-49aa-a633-605ec4c8a80f", + "image_id": 203255, + "image_name": "119949.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 263.416, + 3233.914, + 1377.978, + 153.11400000000003 + ], + "priority": 8, + "parents": [ + 70636 + ], + "children": [], + "area": 851864.690224, + "iscrowd": 0, + "segmentation": [], + "text": "Linked Open Data is structured using standardized practices, allowing it to\nserve as a “point of truth” data, store and allowing active and automatic\ntransfer from eagle-i to other websites." + }, + { + "id": 70637, + "strid": "d8417064-88a5-4ed3-8af3-c297ee1d9f4c", + "image_id": 203255, + "image_name": "119949.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1794.986, + 790.205, + 1490.762, + 91.61000000000001 + ], + "priority": 9, + "parents": [ + 70660 + ], + "children": [ + 70645, + 70646, + 70648, + 70644, + 70649, + 70647 + ], + "area": 1418406.91213, + "iscrowd": 0, + "segmentation": [], + "text": "Current stem cell ontology and data model" + }, + { + "id": 70644, + "strid": "b1b110c6-ae91-4984-848c-30b5d786d823", + "image_id": 203255, + "image_name": "119949.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1753.529, + 933.999, + 426.8800000000001, + 237.55899999999997 + ], + "priority": 10, + "parents": [ + 70637 + ], + "children": [], + "area": 1637794.332471, + "iscrowd": 0, + "segmentation": [], + "text": "Data structure: The eagle-i ontology uses\nhierarchical classification to organize related\nconcepts from broad to specific terms.\n\nAs shown below, the Cell line class can be\nbroken down into the following sub-classes:\nImmortalized Cell lines, Primary Cell lines and\nStem Cell lines. Each of those contains\nadditional its own sub-classes, all of which\ninherit the properties of the classes above." + }, + { + "id": 70648, + "strid": "901b2503-59cd-4e62-915d-4cd409f9f99d", + "image_id": 203255, + "image_name": "119949.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2261.816, + 959.557, + 302.8000000000002, + 215.0999999999999 + ], + "priority": 11, + "parents": [ + 70637 + ], + "children": [], + "area": 2170341.3755119997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 70645, + "strid": "9664179e-0561-4daf-98ba-19873b4b43d8", + "image_id": 203255, + "image_name": "119949.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2639.152, + 925.834, + 669.71, + 127.72300000000007 + ], + "priority": 12, + "parents": [ + 70637 + ], + "children": [], + "area": 2443416.652768, + "iscrowd": 0, + "segmentation": [], + "text": "Data annotation: Each ontology class contains synonyms, a definition, a\ndurable URI, and properties that are used to describe resources of that\ntype. Annotating an iPSC record with the “Induced Pluripotent Stem Cell\nline” type causes the record to populate with fields specific to iPS cells,\nseen below." + }, + { + "id": 70646, + "strid": "5bd67730-f43a-495c-8c2e-93b04a083293", + "image_id": 203255, + "image_name": "119949.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2637.182, + 1057.779, + 665.0299999999997, + 239.856 + ], + "priority": 13, + "parents": [ + 70637 + ], + "children": [], + "area": 2789555.7387779998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 70647, + "strid": "ca05c763-f873-4f3d-93ff-a24308d35525", + "image_id": 203255, + "image_name": "119949.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1725.812, + 1219.036, + 1629.571, + 1976.5820000000003 + ], + "priority": 14, + "parents": [ + 70637 + ], + "children": [], + "area": 2103826.957232, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 70649, + "strid": "67d69d2a-7604-419b-ac2b-e7a14d382223", + "image_id": 203255, + "image_name": "119949.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1753.61, + 3250.625, + 1554.707, + 295.86900000000014 + ], + "priority": 15, + "parents": [ + 70637 + ], + "children": [], + "area": 5700328.50625, + "iscrowd": 0, + "segmentation": [], + "text": "Semantic connections: The diagram above exposes a small section of the eagle-i data model, demonstrating the types of connections\nused for linking stem cell related resources. A set of Induced Pluripotent Stem Cells (iPSCs) are “derived_from” a common primary cell\nculture, which itself is derived from a biospecimen that was “collected_from” a human subject. The Human Subject in turn can be a\nspecific “part_of” a family (proband or relative) and/or a Human Study. Additionally, a modified version of one of the iPSC lines has\nbeen linked to its parental line.\n\nEach of the nodes of the graph above represents a unique eagle-i record that itself contains annotations derived from the ontology for\nthat class, as shown for Human Subject in the box. The Human subject record can additionally be linked to other records (not shown\nhere), such as animal models or constructs (based on sharing the same genetic modification, related disease, or gene linked to that\ndisease). The richness of these connections creates the potential for the development of highly specific queries." + }, + { + "id": 70638, + "strid": "8fcc5110-a04f-4e4f-88b4-9985aa841d99", + "image_id": 203255, + "image_name": "119949.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3689.699, + 825.699, + 734.8870000000002, + 85.72400000000005 + ], + "priority": 16, + "parents": [ + 70660 + ], + "children": [ + 70650, + 70653, + 70651, + 70652 + ], + "area": 3046580.774601, + "iscrowd": 0, + "segmentation": [], + "text": "NYSCF iPS cell lines" + }, + { + "id": 70653, + "strid": "0bf63a69-e631-4f29-a3fe-80c62c40bac9", + "image_id": 203255, + "image_name": "119949.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3443.021, + 940.565, + 879.8759999999997, + 44.75199999999995 + ], + "priority": 17, + "parents": [ + 70638 + ], + "children": [], + "area": 3238385.0468650004, + "iscrowd": 0, + "segmentation": [], + "text": "Example query using the semantic architecture:" + }, + { + "id": 70651, + "strid": "cc958683-700e-46e5-95df-55a796111dc7", + "image_id": 203255, + "image_name": "119949.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3444.315, + 1044.902, + 646.9079999999999, + 779.0360000000001 + ], + "priority": 18, + "parents": [ + 70638 + ], + "children": [], + "area": 3598971.6321300003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 70652, + "strid": "841c1c71-d54e-4bff-8ee2-deca3c7de6ca", + "image_id": 203255, + "image_name": "119949.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 4121.735, + 991.797, + 536.7439999999997, + 470.72800000000007 + ], + "priority": 19, + "parents": [ + 70638 + ], + "children": [], + "area": 4087924.407795, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 70650, + "strid": "fb72bb2d-edda-46f2-9912-400a0591722b", + "image_id": 203255, + "image_name": "119949.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 4199.212, + 1590.875, + 642.9440000000004, + 230.61000000000013 + ], + "priority": 20, + "parents": [ + 70638 + ], + "children": [], + "area": 6680421.390500001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 70639, + "strid": "b4b79b97-c2da-4e4c-a3e0-696dff37a988", + "image_id": 203255, + "image_name": "119949.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3669.24, + 1907.224, + 1014.7349999999997, + 92.72499999999991 + ], + "priority": 21, + "parents": [ + 70660 + ], + "children": [ + 70657, + 70655, + 70658, + 70654, + 70659, + 70656 + ], + "area": 6998062.589759999, + "iscrowd": 0, + "segmentation": [], + "text": "Caveats and ongoing work" + }, + { + "id": 70654, + "strid": "8b783a37-86fc-488e-9744-f7a84c7859f8", + "image_id": 203255, + "image_name": "119949.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3438.088, + 2022.839, + 1462.02, + 354.14800000000014 + ], + "priority": 22, + "parents": [ + 70639 + ], + "children": [], + "area": 6954698.491832, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 70655, + "strid": "0589400c-b607-4d7d-ba8e-5fcdd07b5359", + "image_id": 203255, + "image_name": "119949.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3445.03, + 2428.533, + 1045.9519999999998, + 278.79800000000023 + ], + "priority": 23, + "parents": [ + 70639 + ], + "children": [], + "area": 8366369.040990001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 70656, + "strid": "e38ec15b-5b2e-4b6b-850b-ab410d8092a3", + "image_id": 203255, + "image_name": "119949.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3463.23, + 2773.772, + 1147.9879999999998, + 174.5250000000001 + ], + "priority": 24, + "parents": [ + 70639 + ], + "children": [], + "area": 9606210.40356, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 70659, + "strid": "3d89f598-f1e4-4528-a146-8860dde42163", + "image_id": 203255, + "image_name": "119949.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 4591.153, + 2506.659, + 309.5159999999996, + 260.625 + ], + "priority": 25, + "parents": [ + 70639 + ], + "children": [], + "area": 11508454.987827001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 70658, + "strid": "04ffe441-ac06-43c5-9637-ebfcefeacc9c", + "image_id": 203255, + "image_name": "119949.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3671.908, + 2989.346, + 980.7170000000001, + 275.04100000000017 + ], + "priority": 26, + "parents": [ + 70639 + ], + "children": [], + "area": 10976603.492168, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 70657, + "strid": "a1b97775-e2db-4ca4-8ef3-4e8931738863", + "image_id": 203255, + "image_name": "119949.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3447.131, + 3353.101, + 1342.0359999999996, + 214.86200000000008 + ], + "priority": 27, + "parents": [ + 70639 + ], + "children": [], + "area": 11558578.403231, + "iscrowd": 0, + "segmentation": [], + "text": "Since the beginning of the eagle-i project, we’ve developed our ontology and software around input from researchers who will\nultimately use the tool. If you have suggestions for a desired functionality, ontology improvements, would like to publish information\nabout your lab’s stem cell resources, or would like to see other collections added to our database, please let us know. Contact\ninformation: (general feedback), (for specific or detailed requests or to submit cell line\ninformation). For eagle-i news see our feed at eagle-i.net or follow us on Twitter (@eagleinetwork) or like us on Facebook\n(www.facebook.com/ »)" + }, + { + "id": 92261, + "strid": "093428b8-8eea-4091-8efa-ec651a0e7cc8", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 594.22, + 194.28, + 235.85000000000002, + 235.85999999999999 + ], + "priority": -1, + "parents": [], + "children": [ + 92221, + 92219, + 92226, + 92222, + 92224, + 92223, + 92225, + 92220 + ], + "area": 115445.0616, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 92219, + "strid": "c05eec68-62ac-4e4f-b522-77e29cdf7503", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 1050.018, + 203.02, + 6903.046, + 342.552 + ], + "priority": 1, + "parents": [ + 92261 + ], + "children": [], + "area": 213174.65436000002, + "iscrowd": 0, + "segmentation": [], + "text": "Hematologic and Renal Improvements in Response to Eculizumab in Atypical\nHemolytic Uremic Syndrome Patients With Long Disease Duration and Chronic Kidney Disease" + }, + { + "id": 92220, + "strid": "53d4ca41-7edf-4a68-bb21-df745aee916b", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 344.365, + 561.076, + 8311.963, + 137.39999999999998 + ], + "priority": 2, + "parents": [ + 92261 + ], + "children": [], + "area": 193214.93674, + "iscrowd": 0, + "segmentation": [], + "text": "Christoph Licht,' Petra Muus,? Christophe M. Legendre,* Yahsou Delmas,’ Maria Herthelius,° Camille L. Bedrosian,® Chantal Loirat’\n\n‘The Hospital for Sick Children, Toronto, ON, Canada; 7Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; “Université Paris Descartes and H6épital Necker, Paris, France; “CHU Pellegrin-Bordeaux, Bordeaux, France; °Karolinska University Hospital, Stockholm, Sweden; *Alexion Pharmaceuticals, Inc., Cheshire, CT, USA; 7Assistance Publique-H6pitaux de Paris; H6pital Robert-Debré, Paris, France" + }, + { + "id": 92221, + "strid": "2cc0f0d2-8949-4371-90cd-56207929a8fc", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 113.853, + 937.419, + 469.0729999999999, + 53.629999999999995 + ], + "priority": 3, + "parents": [ + 92261 + ], + "children": [ + 92229, + 92227, + 92228 + ], + "area": 106727.965407, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 92227, + "strid": "9dae8081-0e23-47f3-9d57-07b4ee0b3662", + "image_id": 204074, + "image_name": "121411.png", + 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"priority": 9, + "parents": [ + 92222 + ], + "children": [], + "area": 303579.384864, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 92233, + "strid": "c7c1a3fb-0fcc-414c-ad93-bc20d5a7ae0b", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 97.159, + 3400.865, + 1611.764, + 563.9629999999997 + ], + "priority": 10, + "parents": [ + 92222 + ], + "children": [], + "area": 330424.642535, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 92234, + "strid": "bfceac41-ca0f-4cdd-b655-fd542c83c607", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1879.406, + 940.304, + 1680.382, + 521.2500000000001 + ], + "priority": 11, + "parents": [ + 92222 + ], + "children": [], + "area": 1767212.9794239998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 92223, + "strid": "6c84f25b-2b13-4aaf-95be-dbc3cc5c41d3", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1895.541, + 1496.222, + 271.83000000000015, + 50.91599999999994 + ], + "priority": 12, + "parents": [ + 92261 + ], + "children": [ + 92248, + 92242, + 92238, + 92244, + 92251, + 92243, + 92247, + 92235, + 92230, + 92253, + 92254, + 92236, + 92252, + 92246, + 92237, + 92245, + 92250, + 92249 + ], + "area": 2836150.146102, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 92230, + "strid": "7aadcb92-b587-4163-bf5d-d0c2c6625b2a", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1879.537, + 1594.644, + 1538.0199999999998, + 275.84899999999993 + ], + "priority": 13, + "parents": [ + 92223 + ], + "children": [], + "area": 2997192.399828, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 92248, + "strid": "d682f078-9ea8-4f3c-bd1b-bb250009550b", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1876.633, + 1974.682, + 1687.9019999999998, + 1893.155 + ], + "priority": 14, + "parents": [ + 92223 + ], + "children": [ + 92256 + ], + "area": 3705753.405706, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 92256, + "strid": "d9d683d9-3962-47d9-b9cb-3fa0dc0bb5a1", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1876.215, + 1924.466, + 1112.829, + 39.174999999999955 + ], + "priority": 15, + "parents": [ + 92248 + ], + "children": [], + "area": 3610711.97619, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1. Trial CO8-003: Baseline Disease Characteristics" + }, + { + "id": 92244, + "strid": "0a1aeeba-a4c4-415a-a823-050bf79a2486", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1878.978, + 3885.889, + 1633.1819999999998, + 57.478999999999814 + ], + "priority": 16, + "parents": [ + 92223 + ], + "children": [], + "area": 7301499.941442001, + "iscrowd": 0, + "segmentation": [], + "text": "aHUS, atypical hemolytic uremic syndrome; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; LDH, lactate dehydrogenase;\nUBN, upper limit of normal." + }, + { + "id": 92245, + "strid": "84dcac83-a019-4d76-9006-beb1e1ea1737", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1880.245, + 3977.028, + 1350.5410000000002, + 45.641999999999825 + ], + "priority": 17, + "parents": [ + 92223 + ], + "children": [], + "area": 7477787.011859999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 92235, + "strid": "6db4bb31-25b0-48aa-a3a4-2854de8c3e3e", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3657.883, + 938.996, + 1634.5439999999999, + 219.43099999999993 + ], + "priority": 18, + "parents": [ + 92223 + ], + "children": [], + "area": 3434737.5054679997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 92249, + "strid": "d3c6b244-af7f-4809-a184-dba0fb1f21c4", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3676.998, + 1297.497, + 1645.9870000000005, + 661.2160000000001 + ], + "priority": 19, + "parents": [ + 92223 + ], + "children": [ + 92257 + ], + "area": 4770893.874006, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 92257, + "strid": "f1838e6e-af3d-4b6d-81aa-cf86ace68c8c", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 3658.878, + 1194.229, + 1654.538, + 94.51600000000008 + ], + "priority": 20, + "parents": [ + 92249 + ], + "children": [], + "area": 4369538.215062001, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. Proportion of Patients Meeting the for TMA Event-Free Status and\nHematologic Normalization at 26 Weeks and.at’i and 2 Years" + }, + { + "id": 92246, + "strid": "26ad06a9-2c3f-43ca-bcc4-16be44bba09f", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3658.111, + 1971.455, + 1675.8059999999996, + 147.97800000000007 + ], + "priority": 21, + "parents": [ + 92223 + ], + "children": [], + "area": 7211801.221504999, + "iscrowd": 0, + "segmentation": [], + "text": "TMA event-free status was defined as >12 weeks with no decrease in platelet count of >25%, no PE/PI, and no initiation of dialysissfor >2 consecutive\nmeasurements, 24 weeks apart.\n\n*95% confidence interval.\ntMedian treatment duration for the 1-year analysis was 62 weeks.\n+Median treatment duration for the 2-year analysis was 114 weeks." + }, + { + "id": 92236, + "strid": "4ccb858d-f668-45a5-9018-5c94b43173a3", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3659.693, + 2156.807, + 1668.0919999999996, + 312.45600000000013 + ], + "priority": 22, + "parents": [ + 92223 + ], + "children": [], + "area": 7893251.480250999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 92253, + "strid": "81085ad7-89f6-4ad0-be7f-12d69216f63a", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 3657.895, + 2556.878, + 1686.3650000000002, + 237.89199999999983 + ], + "priority": 23, + "parents": [ + 92223 + ], + "children": [ + 92259 + ], + "area": 9352791.251810001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 92259, + "strid": "450195a7-244b-424a-8899-ffb90f29e2ba", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 3657.22, + 2505.075, + 1292.0850000000005, + 43.9050000000002 + ], + "priority": 24, + "parents": [ + 92253 + ], + "children": [], + "area": 9161610.391499998, + "iscrowd": 0, + "segmentation": [], + "text": "Table 2. Change in Renal Outcomes With Eculizumab Treatment" + }, + { + "id": 92247, + "strid": "452bd0e8-9b36-428d-bb1b-010884ff6a8a", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3658.397, + 2801.818, + 1337.5100000000002, + 148.05299999999988 + ], + "priority": 25, + "parents": [ + 92223 + ], + "children": [], + "area": 10250162.565746, + "iscrowd": 0, + "segmentation": [], + "text": "“At data cutoff (median 114 weeks) unless otherwise noted.\n\nTAt 104 weeks.\n\n*Evaluable patients.\n\nFor all parameters, improvement was seen in at least two consecutive measurements over 4 weeks.\n\nCl, confidence internal; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; SD, standard deviation." + }, + { + "id": 92251, + "strid": "4785cb63-5e1f-4a0e-b7cb-eeccd5a357da", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3668.012, + 3037.218, + 1667.3020000000001, + 930.7829999999999 + ], + "priority": 26, + "parents": [ + 92223 + ], + "children": [ + 92260 + ], + "area": 11140552.070616, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 92260, + "strid": "6cd1dd0e-514a-4cc8-bc7f-be6ed53c1337", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 3659.798, + 2982.971, + 1395.103, + 44.53099999999995 + ], + "priority": 27, + "parents": [ + 92251 + ], + "children": [], + "area": 10917071.299858, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2. Improvement in @€GFR Over 2 Years of Eculizumab Treatment" + }, + { + "id": 92252, + "strid": "ae3780c2-0a6b-4080-b7f9-fcc3759305e8", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3658.299, + 3977.933, + 470.02899999999954, + 54.78099999999995 + ], + "priority": 28, + "parents": [ + 92223 + ], + "children": [], + "area": 14552468.315967, + "iscrowd": 0, + "segmentation": [], + "text": "eGFR, estimated glomerular filtration rate.\n*P<0.05; tP<0.01: #P<0.001; §P<0.0001." + }, + { + "id": 92237, + "strid": "6ea40348-f8e4-4035-89a2-1097cc70e828", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 5435.198, + 939.927, + 1582.2780000000002, + 1008.2489999999999 + ], + "priority": 29, + "parents": [ + 92223 + ], + "children": [], + "area": 5108689.3505460005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 92250, + "strid": "58786f14-882e-424c-9c59-1bd883e5d7c1", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 5447.309, + 2075.981, + 1664.7420000000002, + 1760.129 + ], + "priority": 30, + "parents": [ + 92223 + ], + "children": [ + 92258 + ], + "area": 11308509.985129002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 92258, + "strid": "433f6deb-bee6-4bf7-a593-c9216ba97b9c", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 5437.563, + 1971.605, + 1385.0699999999997, + 94.98599999999988 + ], + "priority": 31, + "parents": [ + 92250 + ], + "children": [], + "area": 10720726.398615, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3. Cumulative Percentage of Patients “mrs the Criteria for\nKey Hematologic and Renal Parameters**" + }, + { + "id": 92242, + "strid": "0e9032da-615b-41ba-bc71-61217f17a9e4", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 5437.527, + 3849.717, + 1657.5529999999999, + 177.88400000000001 + ], + "priority": 32, + "parents": [ + 92223 + ], + "children": [], + "area": 20932940.129859, + "iscrowd": 0, + "segmentation": [], + "text": "“Data are reported to a median duration of exposure of 114 weeks.\n\n*Based on predefined thresholds for each outcome, an observed improvement must be sustained for 22 consecutive measurements >4 weeks apart\n(Week 4 is thus the earliest time point at which an improvement could be observed).\n\n*Eculizumab treatment duration,in’primary analysis.\n\nSMedian duration of treatment at 1- and 2-year data cutoffs, respectively.\n\nCKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; LDH, lactate dehydrogenase; ULN, upper limit of normal." + }, + { + "id": 92238, + "strid": "67f1a962-b500-4bb8-b5f5-6d30bd25b4fd", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 7216.346, + 939.305, + 1682.121000000001, + 721.6530000000001 + ], + "priority": 33, + "parents": [ + 92223 + ], + "children": [], + "area": 6778349.87953, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 92254, + "strid": "d41d0d5f-24b6-4145-9cdb-f0fdf9309d2d", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 7216.843, + 1781.517, + 1686.4469999999992, + 322.48800000000006 + ], + "priority": 34, + "parents": [ + 92223 + ], + "children": [ + 92255 + ], + "area": 12856928.490831, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 92255, + "strid": "5e3a8e07-ab54-4e1f-9acb-e6a8f71f41ca", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 7216.457, + 1725.372, + 1040.2759999999998, + 45.361000000000104 + ], + "priority": 35, + "parents": [ + 92254 + ], + "children": [], + "area": 12451072.847004002, + "iscrowd": 0, + "segmentation": [], + "text": "Table 3. Safety of Long-Term Eculizimab Treatment" + }, + { + "id": 92243, + "strid": "9a680a57-feb3-4080-bf22-c89c0e80f8b9", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 7217.85, + 2111.782, + 726.4579999999996, + 58.2800000000002 + ], + "priority": 36, + "parents": [ + 92223 + ], + "children": [], + "area": 15242525.708700001, + "iscrowd": 0, + "segmentation": [], + "text": "“Greatest severity of adverse events reported among all patients.\ntPatient was receiving peritoneal dialysis." + }, + { + "id": 92224, + "strid": "c875e75c-fca4-464f-bf05-25f0efee0949", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 7238.312, + 2256.023, + 450.384, + 52.67000000000007 + ], + "priority": 37, + "parents": [ + 92261 + ], + "children": [ + 92239 + ], + "area": 16329798.353176001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 92239, + "strid": "6a1706f3-e7c9-4a3b-a03e-f5992b224d4e", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 7231.918, + 2350.838, + 1655.853000000001, + 807.527 + ], + "priority": 38, + "parents": [ + 92224 + ], + "children": [], + "area": 17001067.647284, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 92226, + "strid": "f74847de-dbc8-4e94-8977-c8dce687363a", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 7229.791, + 3790.188, + 659.4809999999998, + 51.65099999999984 + ], + "priority": 39, + "parents": [ + 92261 + ], + "children": [ + 92241 + ], + "area": 27402267.090708002, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 92241, + "strid": "a271be57-7d6c-449c-b60c-a80f51bb98ff", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 7226.568, + 3879.135, + 1637.4659999999994, + 94.54300000000012 + ], + "priority": 40, + "parents": [ + 92226 + ], + "children": [], + "area": 28032832.858680002, + "iscrowd": 0, + "segmentation": [], + "text": "The authors would like to acknowledge Kenyon Ogburn of Alexion Pharmaceuticals; Inc\nfor writing and editorial support." + }, + { + "id": 92225, + "strid": "cf881fc7-29c7-40c0-8836-27e927a140c1", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 7234.905, + 3250.4, + 406.40399999999954, + 51.097999999999956 + ], + "priority": 41, + "parents": [ + 92261 + ], + "children": [ + 92240 + ], + "area": 23516335.212, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 92240, + "strid": "d725ded5-19e5-45a5-abee-ec0b3f8b06d2", + "image_id": 204074, + "image_name": "121411.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 7217.935, + 3335.451, + 1480.9000000000005, + 390.65499999999975 + ], + "priority": 42, + "parents": [ + 92225 + ], + "children": [], + "area": 24075068.513685003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 98079, + "strid": "b6186edd-19f9-4418-a957-dc6e8fc2267c", + "image_id": 204296, + "image_name": "121795.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 145.83, + 71.04, + 23.75999999999999, + 41.58 + ], + "priority": -1, + "parents": [], + "children": [ + 98057, + 98061, + 98059, + 98060, + 98058, + 98063, + 98062 + ], + "area": 10359.763200000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 98057, + "strid": "b0748b8b-3e33-4766-a390-1a4cc6bb54e2", + "image_id": 204296, + "image_name": "121795.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 152.898, + 3.212, + 504.9789999999999, + 46.849 + ], + "priority": 1, + "parents": [ + 98079 + ], + "children": [], + "area": 491.108376, + "iscrowd": 0, + "segmentation": [], + "text": "Ventilatory response during intentional early rehabilitation\nin patients with a mechanical ventilation" + }, + { + "id": 98058, + "strid": "a2c4209f-80f0-4982-8e36-966922839cde", + "image_id": 204296, + "image_name": "121795.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 214.162, + 58.17, + 425.696, + 51.804 + ], + "priority": 2, + "parents": [ + 98079 + ], + "children": [], + "area": 12457.80354, + "iscrowd": 0, + "segmentation": [], + "text": "K.Obata’?, N.Shiba?, TTakahashi?, S.{chiba?, Y.Ujike?\n\nnpanec dss Okayama Hopital Departent of etbiltion Oyama span\n2Otajama Unerity Grdute eos| of Mane, Departmen of merge ards Care Medline Oksana apn\nee eee ee ee ee eee emery ae Cacal care Medici" + }, + { + "id": 98059, + "strid": "edeb70f9-fb88-47c6-a55b-2b118b8eee9b", + "image_id": 204296, + "image_name": "121795.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 357.412, + 134.75, + 131.538, + 20.271000000000015 + ], + "priority": 3, + "parents": [ + 98079 + ], + "children": [ + 98071 + ], + "area": 48161.267, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 98071, + "strid": "0def8bbd-b9f2-4c35-8021-0c79d9643bfd", + "image_id": 204296, + "image_name": "121795.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 47.635, + 172.281, + 753.687, + 45.69800000000001 + ], + "priority": 4, + "parents": [ + 98059 + ], + "children": [], + "area": 8206.605435, + "iscrowd": 0, + "segmentation": [], + "text": "intentional early rehabilitation with a mechanical ventilation in intensive care units is performed in clinical settings. However, strict indexes for\nsafe rehabilitation have not been fully elucidated. The purpose of this study is to analyze ventilator response (VR) between healthy volunteers and\npatients with a mechanical ventilation. Then we examined safe rehabilitation." + }, + { + "id": 98060, + "strid": "bb55f9b6-932b-4305-b0d0-c6d37aec5861", + "image_id": 204296, + "image_name": "121795.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 380.837, + 236.106, + 84.68899999999996, + 20.271000000000015 + ], + "priority": 5, + "parents": [ + 98079 + ], + "children": [ + 98075, + 98078, + 98076, + 98070, + 98077, + 98072 + ], + "area": 89917.90072199999, + "iscrowd": 0, + "segmentation": [], + "text": "Method" + }, + { + "id": 98070, + "strid": "84c4b669-24cd-43a2-8642-d73ce5eab42c", + "image_id": 204296, + "image_name": "121795.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 42.999, + 276.923, + 378.168, + 367.572 + ], + "priority": 6, + "parents": [ + 98060 + ], + "children": [], + "area": 11907.412077, + "iscrowd": 0, + "segmentation": [], + "text": "Sixteen healthy volunteers(Control group) and 13 patients on a\nmechanical ventilation(MV group) were enrolled in this study. The MV\ngroup was given to -1 from 1 on Richmond Agitation-Sedation scale. Both\ngroups were positioned in a variety of postures(baseline in a supine\nposition, settied back 30 degrees, settled back 60 degrees, and sitting\nposition) and measured with an indirect calorimeter(GE Healthcare S/5\ncompact monitor: IC).\n\nThe instantaneous energy expenditure (EE), tidal volume(TV},\nrespiratory rate(RR) and minute expiratory volume(VE) were non:\ninvasively measured in each posture. The VE was indexed by body\nweight and the EE was also indexed by the basal energy\nexpenditure(BEE) estimated by the Harris-Benedict formula . VR was\ndefined as the slope in the indexed VE- indexed EE plot with an\nassumption of those relationship in the linear manner.\n\nIndexed VE(L/ke) = MV/weight(ke)\n\nindexed EE(L/min Actualaluesof the EE at each posture\ntndexed EE(L/min/ke/BEE) = cred value on Har Benedict Equaton®\n\n \n\nWe examined the correlation between indexed EE and indexed VE\nin both groups, and the differences of the maximal indexed EE, the\n‘maximal indexed MV, and the others between both groups were\ninvestigated using the unpaired t test. For all the data, significance\nwas accepted at values of p< 0.05." + }, + { + "id": 98078, + "strid": "7746ed6e-105e-4835-9672-0b500cff63bb", + "image_id": 204296, + "image_name": "121795.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 493.564, + 270.445, + 216.872, + 95.10700000000003 + ], + "priority": 7, + "parents": [ + 98060 + ], + "children": [], + "area": 133481.91598, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 98072, + "strid": "5a082455-d5b9-49b8-8e02-f238b9ca08f8", + "image_id": 204296, + "image_name": "121795.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 418.089, + 376.272, + 379.63100000000003, + 165.627 + ], + "priority": 8, + "parents": [ + 98060 + ], + "children": [], + "area": 157315.184208, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 98076, + "strid": "e1fe5447-de10-4585-bb87-cc0df8731f76", + "image_id": 204296, + "image_name": "121795.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 549.764, + 556.486, + 92.94500000000005, + 13.690000000000055 + ], + "priority": 9, + "parents": [ + 98060 + ], + "children": [], + "area": 305935.969304, + "iscrowd": 0, + "segmentation": [], + "text": "Indirect Calori" + }, + { + "id": 98075, + "strid": "67a11a84-92f8-4a27-98f8-22538e8726c3", + "image_id": 204296, + "image_name": "121795.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 422.234, + 571.616, + 190.21300000000002, + 98.70900000000006 + ], + "priority": 10, + "parents": [ + 98060 + ], + "children": [], + "area": 241355.71014399998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 98077, + "strid": "945ae2d9-34af-495a-935a-82bf4f9eafce", + "image_id": 204296, + "image_name": "121795.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 614.609, + 572.337, + 185.89, + 92.22500000000002 + ], + "priority": 11, + "parents": [ + 98060 + ], + "children": [], + "area": 351763.471233, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 98061, + "strid": "6c7848ea-5c2b-4af3-8bcc-d22823f5a15c", + "image_id": 204296, + "image_name": "121795.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 385.792, + 693.335, + 75.67900000000003, + 21.623000000000047 + ], + "priority": 12, + "parents": [ + 98079 + ], + "children": [ + 98067, + 98073, + 98068, + 98074, + 98069, + 98066 + ], + "area": 267483.09632, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 98069, + "strid": "d540d005-74be-446f-a2d1-22d8e70f83ce", + "image_id": 204296, + "image_name": "121795.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 62.624, + 740.156, + 332.46, + 14.019000000000005 + ], + "priority": 13, + "parents": [ + 98061 + ], + "children": [], + "area": 46351.529343999995, + "iscrowd": 0, + "segmentation": [], + "text": "Correlation between indexed EE and indexed VE" + }, + { + "id": 98073, + "strid": "4d29cdad-5e64-4152-bcd2-189c19565c07", + "image_id": 204296, + "image_name": "121795.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 100.618, + 768.343, + 238.425, + 334.457 + ], + "priority": 14, + "parents": [ + 98061 + ], + "children": [], + "area": 77309.13597399999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 98066, + "strid": "a8178704-9acd-4974-83ad-a6993c5ea802", + "image_id": 204296, + "image_name": "121795.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 60.472, + 1109.17, + 348.992, + 47.17900000000009 + ], + "priority": 15, + "parents": [ + 98061 + ], + "children": [], + "area": 67073.72824000001, + "iscrowd": 0, + "segmentation": [], + "text": "There was a significant correlation between the indexed the EE and\nindexed the VE in both groups (R=0.51, P<0.0001 in the control\ngroup; R=0.63, P<0.0001 in the MV group)." + }, + { + "id": 98068, + "strid": "8d9094ef-5690-4557-b342-105b6019ccd0", + "image_id": 204296, + "image_name": "121795.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 502.565, + 739.822, + 229.98499999999996, + 17.35699999999997 + ], + "priority": 16, + "parents": [ + 98061 + ], + "children": [], + "area": 371808.64343, + "iscrowd": 0, + "segmentation": [], + "text": "Differences between both groups" + }, + { + "id": 98074, + "strid": "fe601f07-3d49-44e7-8dfa-2bcb5d66cf3b", + "image_id": 204296, + "image_name": "121795.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 417.856, + 793.51, + 395.33799999999997, + 130.226 + ], + "priority": 17, + "parents": [ + 98061 + ], + "children": [], + "area": 331572.91456, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 98067, + "strid": "84f1f313-8eed-48e1-8284-6d4fc8053849", + "image_id": 204296, + "image_name": "121795.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 430.792, + 957.941, + 357.39399999999995, + 165.4480000000001 + ], + "priority": 18, + "parents": [ + 98061 + ], + "children": [], + "area": 412673.319272, + "iscrowd": 0, + "segmentation": [], + "text": "‘Tha VR was significantly suppressed in the MV group compared to\nthe control group (0.041+0.003 /min/BEE vs. 0.069+0.003,\n/min/BEE, P=0.012; respectively). Although the indexed VE was\ncomparable in the MV and control groups (0.19: 0.07 L/kg vs.\n0,170.04 L/kg, P=0.23; respectively), the indexed EE was shifted to\na higher range in the MV group than in the control group (maximal\nindexed EE; 2.26: 0.68 vs, 1.74:0,20, P=0.008; respectively). The\nTV was smaller (maximal TV; 985:+592 ml vs. 1410-299 mL,\n\n.018; respectively) and the RR was more frequent (maximal RR;\n30:8 /min vs. 16:4 /min, P<0.0001; respectively) in the MV group\nthan in the control group." + }, + { + "id": 98062, + "strid": "7a0197e0-57aa-45bf-93f6-c602504ae87d", + "image_id": 204296, + "image_name": "121795.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 362.634, + 1167.087, + 126.791, + 22.2170000000001 + ], + "priority": 19, + "parents": [ + 98079 + ], + "children": [ + 98065 + ], + "area": 423225.427158, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 98065, + "strid": "189c3294-9450-4a57-beb6-72b5e80b1c2c", + "image_id": 204296, + "image_name": "121795.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 54.656, + 1211.283, + 740.639, + 60.10400000000004 + ], + "priority": 20, + "parents": [ + 98062 + ], + "children": [], + "area": 66203.88364799999, + "iscrowd": 0, + "segmentation": [], + "text": "The VR to external stress with a mechanical ventilation is more suppressed than in healthy volunteers. The VE in the mechanical ventilation was\nearned by a higher the RR rather than by increased the TV. Then the MV group significantly increased the RR and the control group\nsignificantly increased the TV for increase of the load. Therefore it revealed that the MV group increase in the VE to increase in the RR to load.\nCareful monitoring of the VE or the RR would be beneficial in early rehabilitation with a mechanical ventilation patients." + }, + { + "id": 98063, + "strid": "7bbda698-7703-4b49-bd01-e90cff69ac9b", + "image_id": 204296, + "image_name": "121795.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 363.4, + 1313.414, + 116.832, + 21.067999999999984 + ], + "priority": 21, + "parents": [ + 98079 + ], + "children": [ + 98064 + ], + "area": 477294.64759999997, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 98064, + "strid": "cd7c768a-4220-4c29-b2c4-1b48ff92b3f2", + "image_id": 204296, + "image_name": "121795.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 56.829, + 1346.228, + 716.949, + 49.159000000000106 + ], + "priority": 22, + "parents": [ + 98063 + ], + "children": [], + "area": 76504.791012, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 191250, + "strid": "a17ef648-d2cf-47cf-a28b-77a5ed0b587a", + "image_id": 207967, + "image_name": "9178.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 739.65, + 126.08, + 308.41999999999996, + 315.13 + ], + "priority": -1, + "parents": [], + "children": [ + 191245, + 191239, + 191238, + 191248, + 191249, + 191246, + 191247 + ], + "area": 93255.072, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 191239, + "strid": "9a2de522-1256-460f-af55-9fef045a98c5", + "image_id": 207967, + "image_name": "9178.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 1095.291, + 114.965, + 4131.797, + 179.855 + ], + "priority": 1, + "parents": [ + 191250 + ], + "children": [], + "area": 125920.129815, + "iscrowd": 0, + "segmentation": [], + "text": "Failure in inhibiting eye movements in a cued probe-matching task" + }, + { + "id": 191238, + "strid": "90dfe4da-8cd3-497e-93e2-fb083bdf92e0", + "image_id": 207967, + "image_name": "9178.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1204.315, + 361.484, + 3913.055, + 320.82200000000006 + ], + "priority": 2, + "parents": [ + 191250 + ], + "children": [], + "area": 435340.60346, + "iscrowd": 0, + "segmentation": [], + "text": "Min-Suk Kang! 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Average score assigned to gaps in TB diagnosis. Higher scores\nindicate greater priority." + }, + { + "id": 61514, + "strid": "3da17db4-eee9-4bc3-be48-4b2fdb690de7", + "image_id": 202926, + "image_name": "119460.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1751.028, + 1342.425, + 393.0400000000002, + 66.70900000000006 + ], + "priority": 18, + "parents": [ + 61542 + ], + "children": [ + 61530, + 61529, + 61524, + 61528, + 61523 + ], + "area": 2350623.7629, + "iscrowd": 0, + "segmentation": [], + "text": "Results (cont.)" + }, + { + "id": 61523, + "strid": "99a1be89-d1eb-40be-80f8-071137972940", + "image_id": 202926, + "image_name": "119460.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1754.064, + 1439.149, + 674.434, + 634.931 + ], + "priority": 19, + "parents": [ + 61514 + ], + "children": [], + "area": 2524359.451536, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61530, + "strid": "0c4906b5-cd15-4478-b22a-9e536631c6af", + "image_id": 202926, + "image_name": "119460.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1732.486, + 2120.084, + 711.2229999999997, + 352.76800000000003 + ], + "priority": 20, + "parents": [ + 61514 + ], + "children": [ + 61525 + ], + "area": 3673015.848824, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61525, + "strid": "3c8ea7bc-a3de-4104-a5d8-f30c0d7ed431", + "image_id": 202926, + "image_name": "119460.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1729.155, + 2477.032, + 674.8900000000001, + 41.33399999999983 + ], + "priority": 21, + "parents": [ + 61530 + ], + "children": [], + "area": 4283172.26796, + "iscrowd": 0, + "segmentation": [], + "text": "Chart 4. 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418493\nCanada Foundation for Innovation John R. Evans Leaders Fund\nReprint requests to: miriam.spering@ubc.ca" + }, + { + "id": 61285, + "strid": "5aca12c2-a559-4f36-99df-a8ea3ee1d96d", + "image_id": 202918, + "image_name": "119448.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 22.68, + 272.58, + 362.21, + 391.78000000000003 + ], + "priority": -1, + "parents": [], + "children": [ + 61268, + 61269, + 61267, + 61266, + 61270, + 61274, + 61275 + ], + "area": 6182.1143999999995, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61266, + "strid": "c37adac4-7dca-4eac-a822-7b4fd2e45a85", + "image_id": 202918, + "image_name": "119448.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 67.683, + 38.037, + 2893.579, + 458.829 + ], + "priority": 1, + "parents": [ + 61285 + ], + "children": [], + "area": 2574.4582710000004, + "iscrowd": 0, + "segmentation": [], + "text": "BRINGING BIOLOGICAL NETWORKS TO\nTHE DESK: COMBINE AND ANALYSE\nWITH NEO4/J AND. CYTOSCAPE" + }, + { + "id": 61267, + "strid": "362afbb4-2954-4f7c-a436-3f525d95bad0", + "image_id": 202918, + "image_name": "119448.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 75.084, + 551.136, + 2634.563, + 222.014 + ], + "priority": 2, + "parents": [ + 61285 + ], + "children": [], + "area": 41381.495424, + "iscrowd": 0, + "segmentation": [], + "text": "Georg Summer*?, Thomas Keldert, Stephane Heymans? and Marijana Radonjict\n\n1 TNO, Microbiology & Systems Biology, Zeist, The Netherlands\n2 Maastricht University, CARIM, Maastricht, The Netherlands be bontinh , ZARA in|" + }, + { + "id": 61269, + "strid": "189b943b-99f0-4689-a070-e7d4882b13f5", + "image_id": 202918, + "image_name": "119448.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 51.944, + 894.298, + 1480.642, + 895.608 + ], + "priority": 3, + "parents": [ + 61285 + ], + "children": [], + "area": 46453.415312000005, + "iscrowd": 0, + "segmentation": [], + "text": "Networks have become a common basis for analysis of\nexperimental data and/or relationships between biological entities\nin general.\n\nCytoscape is a major enabler of this development yet as every\ntechnology faces limitations. Large networks and computational\nintensive algorithms are often solved outside of Cytoscape and\nrequire fiddling around to get the results back into Cytoscape.\nManagement of multiple network sources and scalability further\ncomplicate the work with networks.\n\nWe are working on a system that aims to ease certain tasks and\ncreate a scalable, flexible environment to work with networks. We\nare using Neo4j as a backend solution for the storage and\nCytoscape for the visualization of networks. To better integrate the\nnetwork analysis in existing workflows, we are also working on an R\ninterface for the Neo4j storage." + }, + { + "id": 61270, + "strid": "1587b008-af95-4991-a931-42e42c5318cc", + "image_id": 202918, + "image_name": "119448.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 483.497, + 1842.27, + 601.2849999999999, + 77.64300000000003 + ], + "priority": 4, + "parents": [ + 61285 + ], + "children": [ + 61272, + 61273, + 61276, + 61277 + ], + "area": 890732.01819, + "iscrowd": 0, + "segmentation": [], + "text": "What We Want" + }, + { + "id": 61272, + "strid": "443125d1-02cd-4a24-85d3-60bb74075f37", + "image_id": 202918, + "image_name": "119448.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 117.636, + 1942.355, + 1399.387, + 1038.255 + ], + "priority": 5, + "parents": [ + 61270 + ], + "children": [], + "area": 228490.87278, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61273, + "strid": "42bee63f-feb2-41fa-9ae8-6c1c760c8cc4", + "image_id": 202918, + "image_name": "119448.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 50.998, + 3088.09, + 808.248, + 552.4459999999999 + ], + "priority": 6, + "parents": [ + 61270 + ], + "children": [], + "area": 157486.41382, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61276, + "strid": "b4737e56-d7bc-49fc-94fd-1e0cb9df6916", + "image_id": 202918, + "image_name": "119448.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 876.875, + 3059.257, + 643.9949999999999, + 298.9569999999999 + ], + "priority": 7, + "parents": [ + 61270 + ], + "children": [], + "area": 2682585.981875, + "iscrowd": 0, + "segmentation": [], + "text": "We can do these things\nin Cytoscape! Right?\n\nChallenges:" + }, + { + "id": 61277, + "strid": "c3442039-5ccc-42a2-9b06-02f369def9c3", + "image_id": 202918, + "image_name": "119448.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 883.618, + 3370.577, + 608.0300000000001, + 294.462 + ], + "priority": 8, + "parents": [ + 61270 + ], + "children": [], + "area": 2978302.5075860005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61275, + "strid": "a1e4d1fa-1b52-4058-867d-cf6dceb158ea", + "image_id": 202918, + "image_name": "119448.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 665.153, + 3741.06, + 236.85000000000002, + 81.41699999999992 + ], + "priority": 9, + "parents": [ + 61285 + ], + "children": [ + 61283, + 61284 + ], + "area": 2488377.28218, + "iscrowd": 0, + "segmentation": [], + "text": "Neo4j" + }, + { + "id": 61283, + "strid": "5ff15206-3cf5-4ae9-9a02-faf35719b969", + "image_id": 202918, + "image_name": "119448.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 54.555, + 3838.12, + 1472.309, + 290.34100000000035 + ], + "priority": 10, + "parents": [ + 61275 + ], + "children": [], + "area": 209388.6366, + "iscrowd": 0, + "segmentation": [], + "text": "Neo4j: A java-based databases specifically developed to store\ngraph. A community version is available under a AGPLv3 license.\nNeo4j provides a query language called CYPHER, allowing users to\nmake SQL like queries but with respect to graph topology and\nfeatures." + }, + { + "id": 61284, + "strid": "9118d0f2-0025-426f-975f-2995e705f1c4", + "image_id": 202918, + "image_name": "119448.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 58.301, + 4195.895, + 1466.689, + 301.5799999999999 + ], + "priority": 11, + "parents": [ + 61275 + ], + "children": [], + "area": 244624.87439500002, + "iscrowd": 0, + "segmentation": [], + "text": "Neo4j Plugins: Neo4j has a plugin facility, allowing developers to\ninstall plugins on a server instance that become accessible via the\nNeo4j (embedded/rest) interface. Such plugins can be used to add\ncomputationally intensive and specialized algorithms to the basic\nset of graph algorithms of Neo4j." + }, + { + "id": 61268, + "strid": "b69fa809-2959-4237-8043-45cea9e1c23d", + "image_id": 202918, + "image_name": "119448.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1951.037, + 888.187, + 802.6670000000001, + 74.62400000000002 + ], + "priority": 12, + "parents": [ + 61285 + ], + "children": [ + 61271 + ], + "area": 1732885.699919, + "iscrowd": 0, + "segmentation": [], + "text": "System Description" + }, + { + "id": 61271, + "strid": "8c8d3fd9-7f77-43ed-917e-c947aefd73da", + "image_id": 202918, + "image_name": "119448.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1636.111, + 985.784, + 1462.5849999999998, + 1929.047 + ], + "priority": 13, + "parents": [ + 61268 + ], + "children": [], + "area": 1612852.046024, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61274, + "strid": "73467a56-d60b-4b41-9de1-aefe01a08bc3", + "image_id": 202918, + "image_name": "119448.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2094.882, + 2952.665, + 520.585, + 77.78699999999981 + ], + "priority": 14, + "parents": [ + 61285 + ], + "children": [ + 61280, + 61281, + 61279, + 61278, + 61282 + ], + "area": 6185484.760530001, + "iscrowd": 0, + "segmentation": [], + "text": "Components" + }, + { + "id": 61278, + "strid": "610e47d4-fc4b-4849-83cb-e248a1634f91", + "image_id": 202918, + "image_name": "119448.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1628.014, + 3043.897, + 1461.07, + 179.82400000000007 + ], + "priority": 15, + "parents": [ + 61274 + ], + "children": [], + "area": 4955506.930558, + "iscrowd": 0, + "segmentation": [], + "text": "Nodeset Compendium: A set of nodes that are available in the\nnetwork, including all IDs with which a node can be identified.\nNetworks sharing nodesets can be easily merged." + }, + { + "id": 61279, + "strid": "cf295d97-dff3-40ab-b9df-8e85046f22b4", + "image_id": 202918, + "image_name": "119448.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1624.268, + 3289.282, + 1464.8159999999998, + 166.712 + ], + "priority": 16, + "parents": [ + 61274 + ], + "children": [], + "area": 5342675.495576001, + "iscrowd": 0, + "segmentation": [], + "text": "Reference Network: A network created for a specific purpose\n(project or analysis). If the nodeset overlaps in two networks, they\ncan be combined." + }, + { + "id": 61280, + "strid": "43cde9c2-bd83-4c0d-803d-43224a74e0fe", + "image_id": 202918, + "image_name": "119448.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1622.395, + 3523.428, + 1474.1820000000002, + 292.21399999999994 + ], + "priority": 17, + "parents": [ + 61274 + ], + "children": [], + "area": 5716391.97006, + "iscrowd": 0, + "segmentation": [], + "text": "Network Builder: A combination of (specific) parsers that reads\ncommon formats and databases and writes them into a Neo4j\ndatabase instance primed with a nodeset. The individual parsers\nare responsible for using services of Neo4j (indexing, edge-types) as\nbest as possible." + }, + { + "id": 61281, + "strid": "95acfbe0-6386-484d-b651-80ecec5cba52", + "image_id": 202918, + "image_name": "119448.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1628.014, + 3886.822, + 1461.07, + 174.20400000000018 + ], + "priority": 18, + "parents": [ + 61274 + ], + "children": [], + "area": 6327800.631508, + "iscrowd": 0, + "segmentation": [], + "text": "Network Library: The Network Library represents a collection of\nReference Networks that keeps track of the individual networks and\nserves as a repository to mix and merge them." + }, + { + "id": 61282, + "strid": "3c7bd422-3e4c-4281-b2e4-e4905802ae81", + "image_id": 202918, + "image_name": "119448.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1622.395, + 4120.968, + 1470.4360000000001, + 417.71600000000035 + ], + "priority": 19, + "parents": [ + 61274 + ], + "children": [], + "area": 6685837.8783599995, + "iscrowd": 0, + "segmentation": [], + "text": "Toolbox and Infrastructure Integration: Neo4j provides an\nembedded and REST interface to access the functionality of an\ninstance. On one side this allows for an easier integration of Neo4j\ninstances into existing projects (e.g. SPRING integration). On the\nother side apps for Cytoscape or packages for R can be developed\nto expose specific or the general functionality to both analysis\nenvironments." + }, + { + "id": 85733, + "strid": "130d3584-1c23-42f1-a228-6ec020fdcbca", + "image_id": 203835, + "image_name": "121001.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 105.56, + 272.17, + 366.74, + 244.48999999999995 + ], + "priority": -1, + "parents": [], + "children": [ + 85724, + 85718, + 85716, + 85717, + 85727, + 85715, + 85719 + ], + "area": 28730.2652, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 85715, + "strid": "2ba77241-84d4-43a9-bec1-41d1710eaefb", + "image_id": 203835, + "image_name": "121001.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 152.594, + 76.335, + 3016.303, + 133.178 + ], + "priority": 1, + "parents": [ + 85733 + ], + "children": [], + "area": 11648.26299, + "iscrowd": 0, + "segmentation": [], + "text": "E-motions‘in the visual arts: exploring the-methods" + }, + { + "id": 85716, + "strid": "bc8c35e0-c473-49bc-97ed-985cfe3c2b2e", + "image_id": 203835, + "image_name": "121001.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 901.271, + 263.505, + 1572.941, + 298.751 + ], + "priority": 2, + "parents": [ + 85733 + ], + "children": [], + "area": 237489.41485499998, + "iscrowd": 0, + "segmentation": [], + "text": "Rossana Actis-Grosso, Daniele Zavagno\nUniversita degli Studi di Milano-Bicocca\nItaly" + }, + { + "id": 85717, + "strid": "39827715-42ab-471e-b855-b43d296d83c4", + "image_id": 203835, + "image_name": "121001.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 99.601, + 643.888, + 3123.287, + 494.273 + ], + "priority": 3, + "parents": [ + 85733 + ], + "children": [], + "area": 64131.88868800001, + "iscrowd": 0, + "segmentation": [], + "text": "E-MOTIONS. Last year (Actis-Gosso and Zavagno, EGVP‘2013 now in Actis-Grosso and Zavagno, Art and_Perception, in press) we presented an experiment aimed at\npreliminary testing the hypothesis according to which facial expressions related to specific emotions (i’e. EFEs), such as anger, fear, and joy, incorporate a sense of\ndynamicity and are used to enhance the representation of motion in static artworks.\n\nWe hypothesized that the visually more dynamic emotions are those with ‘unstable’ facial expressions, i.e., expressions that imply muscular tensionsthat cannot be held\nfor long (e.g., rage, grief, amazement: E-motions) whereas static emotions are those which-canNast and even represent a constant facial featuresin-some people. To test\nthis hypothesis we chose eleven static artworks from which we derived twelve human figurés.that were manipulated to produce two sets of-stimuli: headless bodies (Set\n1) and bodiless heads (Set 2). Participants were asked to rate each stimulus for eight emotions (such as joy, sadness, surprise) and perceived dynamicity. As expected,\nwe found that some facial emotions (ijé., disgust, anger and fear) are positively related‘to’the dynamicity attributed to the artworks: those.emotions are the more sudden\nones and thus the more ‘unstable’." + }, + { + "id": 85718, + "strid": "6db222ef-4293-4fbe-a8a0-bff00be35dcf", + "image_id": 203835, + "image_name": "121001.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 329.317, + 1188.591, + 2649.866, + 82.69100000000003 + ], + "priority": 4, + "parents": [ + 85733 + ], + "children": [], + "area": 391423.222347, + "iscrowd": 0, + "segmentation": [], + "text": "This year-we refine our paradigm by facing some methodological and.conceptual aspects." + }, + { + "id": 85719, + "strid": "5108dfbf-309f-4864-8495-40c8ac177f3f", + "image_id": 203835, + "image_name": "121001.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 124.443, + 1385.257, + 640.503, + 119.32400000000007 + ], + "priority": 5, + "parents": [ + 85733 + ], + "children": [ + 85720, + 85722, + 85721 + ], + "area": 172385.536851, + "iscrowd": 0, + "segmentation": [], + "text": "Experiment 1" + }, + { + "id": 85720, + "strid": "aa33df20-deea-46dd-9f77-9e96a33ddb11", + "image_id": 203835, + "image_name": "121001.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 101.079, + 1568.049, + 3105.708, + 146.20499999999993 + ], + "priority": 6, + "parents": [ + 85719 + ], + "children": [], + "area": 158496.824871, + "iscrowd": 0, + "segmentation": [], + "text": "It appears necessary to have participants rate the implicit dynamicity inherent to the terms we intend to use,in future experiments, without any connection to visual stimuli.\nThis step is necessary because positive and negative‘emotions may be conceptualized in different ways:in-terms of dynamicity based on the degree of arousal with which\nthey are usually experienced." + }, + { + "id": 85721, + "strid": "07cb227a-2679-4872-8417-873a3e05a606", + "image_id": 203835, + "image_name": "121001.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 111.672, + 1802.902, + 1444.503, + 729.1109999999999 + ], + "priority": 7, + "parents": [ + 85719 + ], + "children": [], + "area": 201333.672144, + "iscrowd": 0, + "segmentation": [], + "text": "Participants (n=50) have been asked to rate the implicit dynamicity inherent to\n14 terms indicating different emotions; ywithout any connection to visual\nstimuli. We decided to test more words-than in our previous studies (i.e. 14 vs.\n8) because we had the impression that some words do not fully describe the\nemotions depicted by the images; for example, words such as ‘joy’ and\n‘sadness’ are by nature ambiguous as far as arousal is concerned: terms like\n‘cheerfulness’ and ‘despair’ ”appear more suitable, as they imply a higher\ndegree of arousal. Speaking about ‘joy’, the term may stand for a steady\nsense of happinessyorfor cheerfulness or even for euphoria and enthusiasm,\nemotions that are. usually accompanied by sudden motion.\n\nThe words we.tested were of course in Italian: the English translation is not\nalways perfectly overlapping the original meaning, andymore than one\nalternative is possible. Hence, data ought to be considereédyvalid only for the\nItalian words." + }, + { + "id": 85722, + "strid": "edb5e400-2ec8-41f9-9957-121bad84ec66", + "image_id": 203835, + "image_name": "121001.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1915.313, + 1797.743, + 1307.9430000000002, + 775.6669999999999 + ], + "priority": 8, + "parents": [ + 85719 + ], + "children": [], + "area": 3443240.538559, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 85724, + "strid": "f60cf55c-f004-44c6-a4b4-9f8e5ff2de48", + "image_id": 203835, + "image_name": "121001.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 122.567, + 2638.026, + 648.027, + 108.63999999999987 + ], + "priority": 9, + "parents": [ + 85733 + ], + "children": [ + 85723, + 85725, + 85726 + ], + "area": 323334.932742, + "iscrowd": 0, + "segmentation": [], + "text": "Experiment 2" + }, + { + "id": 85725, + "strid": "85fcfd8e-f43c-4d37-ad0e-59cac9b796cf", + "image_id": 203835, + "image_name": "121001.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 107.319, + 2826.716, + 1063.527, + 314.4839999999999 + ], + "priority": 10, + "parents": [ + 85724 + ], + "children": [], + "area": 303360.334404, + "iscrowd": 0, + "segmentation": [], + "text": "We need to build a rich database of EFEs and\ncorresponding headless bodies derived from artworks. In\nparticular, the bodiless heads showing EFEs should be\nnormalized in size and colarcpalette and comprise only\nfrontal and three-quarter portrait poses. Each EFE\nshould be classified in‘terms of the emotion(s) it depicts." + }, + { + "id": 85726, + "strid": "bd6b9e7d-0bc7-4814-9024-414ad4a3529d", + "image_id": 203835, + "image_name": "121001.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 113.66, + 3220.172, + 1064.515, + 246.86500000000024 + ], + "priority": 11, + "parents": [ + 85724 + ], + "children": [], + "area": 366004.74952, + "iscrowd": 0, + "segmentation": [], + "text": "We began creating such data base. We are still in the\nbasic testing stage, and for now we have collected 42\nEFEs and‘had a different group of participants (n=60)\nrate them-in terms of perceived dynamicity without any\nreference to emotions." + }, + { + "id": 85723, + "strid": "8186d6a4-0ac8-48d2-b16d-9a332413a3b6", + "image_id": 203835, + "image_name": "121001.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1289.14, + 2616.496, + 1952.0360000000003, + 961.2550000000001 + ], + "priority": 12, + "parents": [ + 85724 + ], + "children": [], + "area": 3373029.6534400005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 85727, + "strid": "037be96a-c50d-4e0f-8496-0aabb539b8c1", + "image_id": 203835, + "image_name": "121001.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 126.43, + 3584.043, + 648.1759999999999, + 119.2460000000001 + ], + "priority": 13, + "parents": [ + 85733 + ], + "children": [ + 85731, + 85732, + 85730, + 85729, + 85728 + ], + "area": 453130.55649000005, + "iscrowd": 0, + "segmentation": [], + "text": "Experiment 3" + }, + { + "id": 85728, + "strid": "de172646-6a7f-4fad-a9e8-24db42724b6a", + "image_id": 203835, + "image_name": "121001.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 106.359, + 3770.585, + 1056.68, + 151.12300000000005 + ], + "priority": 14, + "parents": [ + 85727 + ], + "children": [], + "area": 401035.65001499996, + "iscrowd": 0, + "segmentation": [], + "text": "We need to test our instruments and_method by testing\nthe fit between word dynamicity ratings, EFEs dynamicity\nratings, and EFEs emotion classifications." + }, + { + "id": 85729, + "strid": "951b3df0-4351-44bc-9071-972ef26e4e2c", + "image_id": 203835, + "image_name": "121001.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 107.455, + 3999.659, + 1063.8, + 208.01999999999998 + ], + "priority": 15, + "parents": [ + 85727 + ], + "children": [], + "area": 429783.357845, + "iscrowd": 0, + "segmentation": [], + "text": "Another group of participants (n=60) performed a\nforced-choice procedure, in which they were asked to\nchoose, for each-face of Experiment 2, a single emotion\nas indicated bythe 14 terms used in Experiment 1." + }, + { + "id": 85730, + "strid": "0c3bf312-af98-4829-9c53-b491642a21a4", + "image_id": 203835, + "image_name": "121001.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 68.053, + 4260.658, + 1297.8340000000003, + 682.915 + ], + "priority": 16, + "parents": [ + 85727 + ], + "children": [], + "area": 289950.55887400004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 85732, + "strid": "ae41491e-5098-48a5-9d74-6502547e3b22", + "image_id": 203835, + "image_name": "121001.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1475.337, + 3614.27, + 1540.712, + 1022.8039999999996 + ], + "priority": 17, + "parents": [ + 85727 + ], + "children": [], + "area": 5332266.25899, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 85731, + "strid": "876a1b5f-53f3-4258-97ff-17cde3d5f132", + "image_id": 203835, + "image_name": "121001.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1386.85, + 4671.453, + 1821.788, + 361.20899999999983 + ], + "priority": 18, + "parents": [ + 85727 + ], + "children": [], + "area": 6478604.59305, + "iscrowd": 0, + "segmentation": [], + "text": "From the synoptical view it appears evident that participants rated“each face as showing a mix of\ndifferent emotions, with very few exceptions. This is particularly true for faces with low scores in\ndynamicity, There is also a discrepancy between dynamicity ratings of EFE’s classified under\ncertain emotions and the dynamicity evoked by the corresponding words (e.g. happyness or\nanger). Participants claimed that they did not always find ‘the exact match for the emotion depicted.\nThisdnforms us that we need to test a larger numberof words to build a comprehensive scale of\nthe degree of dynamicity evoked by emotions." + }, + { + "id": 57159, + "strid": "501a4eaf-90fe-43e7-806c-0f97e156ab11", + "image_id": 202753, + "image_name": "119186.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 845.47, + 616.35, + 240.21000000000004, + 101.14999999999998 + ], + "priority": -1, + "parents": [], + "children": [ + 57146, + 57158, + 57141, + 57155, + 57143, + 57145, + 57144, + 57142 + ], + "area": 521105.43450000003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 57141, + "strid": "f75ef17f-12f1-4c52-aecc-4084dcc0a3f5", + "image_id": 202753, + "image_name": "119186.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 102.087, + 25.18, + 2534.77, + 239.572 + ], + "priority": 1, + "parents": [ + 57159 + ], + "children": [], + "area": 2570.55066, + "iscrowd": 0, + "segmentation": [], + "text": "Provider-InitiatedSHIV Testing & Counseling (PITC)\nfor Children in‘sZimbabwe:Tacklingethe P of PITC" + }, + { + "id": 57142, + "strid": "2adde7b5-5d7b-443b-b58d-1d84947a38aa", + "image_id": 202753, + "image_name": "119186.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 87.486, + 344.375, + 3341.93, + 174.27600000000007 + ], + "priority": 2, + "parents": [ + 57159 + ], + "children": [], + "area": 30127.991250000003, + "iscrowd": 0, + "segmentation": [], + "text": "Kidia K'* Kranzer K'* Dauya E?, Mungofa S4, Hatzold K®, Busza J°, Ncube G®, Bandason T°, Ferrand RA**\n\n1 Icahn School of Medicine at Mount Sinai, NY, US, 2 Biomedical Research & Training Institute, Harare, Zimbabwe, 3 London Schoo! of Hygiene and Tropical Medicine, London, UK,\n4 Harare City Health, Harare, Zimbabwe 5 Population Services International, Harare, Zimbabwe, 6 Ministry of Health and Child Care, Zimbabwe" + }, + { + "id": 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"text": "Unfaithful mirror: A new procedure to decrease the sense of ownership and\nFY ame mR Ray" + }, + { + "id": 167178, + "strid": "92aeffa3-8e8e-4070-8f31-ae5f5ca79baf", + "image_id": 207026, + "image_name": "6802.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 100.71, + 68.767, + 633.259, + 40.772999999999996 + ], + "priority": 2, + "parents": [ + 167201 + ], + "children": [], + "area": 6925.52457, + "iscrowd": 0, + "segmentation": [], + "text": "oli Raat eal eee olde\nPCTS CRChCCoM ni moa cata t a" + }, + { + "id": 167179, + "strid": "9a29b3a7-8102-4270-bf02-eaa52fa09ab8", + "image_id": 207026, + "image_name": "6802.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 380.789, + 123.986, + 65.74099999999999, + 10.50500000000001 + ], + "priority": 3, + "parents": [ + 167201 + ], + "children": [ + 167185 + ], + "area": 47212.504954, + "iscrowd": 0, + "segmentation": [], + "text": "introduction" + }, + { + "id": 167185, + "strid": 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Mlusions could be\ngenerated from the manipulation of these input, such in the case of the Rubber Hand Illusion (Botvinick &\nCohen, 1998) and the enfacement illusion (Sforza et al., 2010). That happens even if the body part could be\nseen only through a mirror (Bertamini et al, 2011). The synchronization between the different stimulations\n(tactile, visual and proprioceptive) is particularly important for these two illusions." + }, + { + "id": 167180, + "strid": "c4452309-982e-4b30-989b-a402fa9135cd", + "image_id": 207026, + "image_name": "6802.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 367.279, + 242.141, + 92.45400000000001, + 13.182999999999993 + ], + "priority": 5, + "parents": [ + 167201 + ], + "children": [ + 167199, + 167198, + 167186 + ], + "area": 88933.304339, + "iscrowd": 0, + "segmentation": [], + "text": "Aims of the study" + }, + { + "id": 167199, + "strid": "9d9efb73-7d6d-4d14-a3f5-1a684131d12c", + "image_id": 207026, + "image_name": "6802.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 24.088, + 248.971, + 138.981, + 108.94100000000003 + ], + "priority": 6, + "parents": [ + 167180 + ], + "children": [], + "area": 5997.213448, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 167186, + "strid": "a5965bc4-38fe-4355-9212-dd1446f05164", + "image_id": 207026, + "image_name": "6802.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 182.802, + 265.053, + 461.374, + 100.38400000000001 + ], + "priority": 7, + "parents": [ + 167180 + ], + "children": [], + "area": 48452.218506, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 167198, + "strid": "6fa9fd5e-f002-4b8a-a2c2-f97dea335ba2", + "image_id": 207026, + "image_name": "6802.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 663.979, + 258.028, + 138.067, + 90.993 + ], + "priority": 8, + "parents": [ + 167180 + ], + "children": [], + "area": 171325.17341200003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 167181, + "strid": "285a8aa5-8b8e-4e85-a86c-16f401a793aa", + "image_id": 207026, + "image_name": "6802.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 386.617, + 379.717, + 53.92099999999999, + 10.627999999999986 + ], + "priority": 9, + "parents": [ + 167201 + ], + "children": [ + 167200, + 167189, + 167187, + 167188, + 167190 + ], + "area": 146805.047389, + "iscrowd": 0, + "segmentation": [], + "text": "Procedure" + }, + { + "id": 167200, + "strid": "b463a2df-bcf3-4e69-8f64-7b74c42294ed", + "image_id": 207026, + "image_name": "6802.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 33.731, + 412.982, + 164.411, + 159.09100000000007 + ], + "priority": 10, + "parents": [ + 167181 + ], + "children": [], + "area": 13930.295842000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 167187, + "strid": "825d3c55-4956-44e4-8669-f43129cd3a86", + "image_id": 207026, + "image_name": "6802.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 208.056, + 403.076, + 410.302, + 195.515 + ], + "priority": 11, + "parents": [ + 167181 + ], + "children": [], + "area": 83862.380256, + "iscrowd": 0, + "segmentation": [], + "text": "Subjects placed their head on the chirrrest In frant of the monitor. The subject's face\nwas recorded through a video camera and projected on the screen. The image was\ninverted soas to match the experience of a miror.\n\nThe experimenter touched the subject’ forehead with a pen three times in three\ndifferent locations, saying ‘one, two, three” aloud. Immediately after, the subject\nrepeated “one, two, three’. The experimenter and the subject repeated this\nprocedure for one minute. Four conditions, differing only in the feedback on the\nsereen that the subject watched, were presented to each subject.\n\nAfter each of the four conditions the subject completed the questionnaire evaluating\nthe sense of agency and ownership.\n\nAt the end of the experiment the subject completed also a battery of the individual\ndifferences questionnaires. Locus of Control Scale (Rotter, 1966); Launey-Slade\nHallucination Scale ~ Revised (Bentall & Slade, 1985}; Peters Delusion Inventory\n(Peters et al. 2004): Cambridge Depersonalisation Scale (Sierra & Berrios, 2000)." + }, + { + "id": 167188, + "strid": "f50c001d-232b-44c9-bf05-596f6efddfda", + "image_id": 207026, + "image_name": "6802.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 671.486, + 389.493, + 78.11500000000001, + 10.764999999999986 + ], + "priority": 12, + "parents": [ + 167181 + ], + "children": [], + "area": 261539.096598, + "iscrowd": 0, + "segmentation": [], + "text": "Four conditions" + }, + { + "id": 167189, + "strid": "52cd101c-6292-47ea-afe5-336a0f95687b", + "image_id": 207026, + "image_name": "6802.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 642.971, + 416.954, + 135.96900000000005, + 60.13100000000003 + ], + "priority": 13, + "parents": [ + 167181 + ], + "children": [], + "area": 268089.330334, + "iscrowd": 0, + 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"children": [ + 167196 + ], + "area": 26898.859835999996, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion" + }, + { + "id": 167196, + "strid": "e1bf6bbf-7f14-4a95-8593-b07726aa9c87", + "image_id": 207026, + "image_name": "6802.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 26.521, + 1014.264, + 464.616, + 127.51300000000003 + ], + "priority": 22, + "parents": [ + 167183 + ], + "children": [], + "area": 26899.295544, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 167184, + "strid": "b24d6605-f169-4452-bbee-7d8089975ef7", + "image_id": 207026, + "image_name": "6802.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 497.465, + 988.351, + 36.186999999999955, + 6.918000000000006 + ], + "priority": 23, + "parents": [ + 167201 + ], + "children": [ + 167197 + ], + "area": 491670.030215, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 167197, + "strid": "66c772b5-470f-4968-811b-b1de12f56f69", + "image_id": 207026, + "image_name": "6802.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 497.827, + 1004.891, + 303.2180000000001, + 128.35299999999995 + ], + "priority": 24, + "parents": [ + 167184 + ], + "children": [], + "area": 500261.871857, + "iscrowd": 0, + "segmentation": [], + "text": "‘alia rt epr.Frsanaty angina ferences 8227523,\nsera Mh, Bel bade owoon, Rk Wor (205, The ra\nabe ns mir Concur nd Conon, 204 68 38\nsoon A tt i agra ag, Mn ay en you: ace\nser it aro ah CmsiaeDpronatn ee ew Wun" + }, + { + "id": 72441, + "strid": "b797422e-2152-44e4-b8bc-df4fc81d28a5", + "image_id": 203324, + "image_name": "120050.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 94.02, + 72.36, + 266.11, + 236.53999999999996 + ], + "priority": -1, + "parents": [], + "children": [ + 72439, + 72424, + 72428, + 72429, + 72427, + 72425, + 72440, + 72426, + 72438 + ], + "area": 6803.2872, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 72424, + "strid": "6ba26e44-f5f7-4599-b735-1b1cee8bfa02", + "image_id": 203324, + "image_name": "120050.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 587.291, + 54.209, + 2385.523, + 190.861 + ], + "priority": 1, + "parents": [ + 72441 + ], + "children": [], + "area": 31836.457819000007, + "iscrowd": 0, + "segmentation": [], + "text": "Studying the Effective Brain Connectivity using the\nMultiregression Dynamic Models" + }, + { + "id": 72425, + "strid": "db7ceb3c-2bdf-492e-ac7b-ece2c5e2e86c", + "image_id": 203324, + "image_name": "120050.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 923.643, + 253.433, + 1735.935, + 98.19900000000001 + ], + "priority": 2, + "parents": [ + 72441 + ], + "children": [], + "area": 234081.616419, + "iscrowd": 0, + "segmentation": [], + "text": "Lilia Costa'; Jim Smith?; Thomas Nichols?\n\n' Universidade Federal da Bahia, Brazil and Dept of Statistics, University of Warwick. ? Dept of Statistics, University of Warwick" + }, + { + "id": 72426, + "strid": "cfd09867-82ff-4f48-b4e5-b7e78a531ed3", + "image_id": 203324, + "image_name": "120050.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 472.942, + 394.896, + 235.38200000000006, + 49.69400000000002 + ], + "priority": 3, + "parents": [ + 72441 + ], + "children": [ + 72430 + ], + "area": 186762.90403200002, + "iscrowd": 0, + "segmentation": [], + "text": "Abstract" + }, + { + "id": 72430, + "strid": "dd178c6f-6654-46fc-a2c7-b503c14ec0d5", + "image_id": 203324, + "image_name": "120050.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 60.381, + 476.203, + 1062.207, + 1014.3020000000001 + ], + "priority": 4, + "parents": [ + 72426 + ], + "children": [], + "area": 28753.613342999997, + "iscrowd": 0, + "segmentation": [], + "text": "The Multiregression Dynamic Model (MDM) is a\nmultivariate graphical model for a multidimensional\ntime series that allows the estimation of time-\nvarying effective connectivity (Costa et al., 2013).\nAn MDM is a state space model where connection\nweights reflect the instantaneous interactions\nbetween brain regions. Because the marginal\nlikelihood has a closed form, model selection across\na large number of potential connectivity networks is\neasy to perform. With application of the Integer\nProgramming Algorithm, we can quickly find\noptimal models that satisfy acyclic graph\nconstraints. Also, due to a factorisation of the\nmarginal likelihood, the search over all possible\ndirected (acyclic or cyclic) graphical structures is\neven faster. These methods are illustrated using\nrecent resting-state and steady-state task fMRI data." + }, + { + "id": 72427, + "strid": "c69cfd87-d52a-454c-b7b7-15a8f6e5d3b0", + "image_id": 203324, + "image_name": "120050.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 144.663, + 1534.99, + 879.8229999999999, + 56.13499999999999 + ], + "priority": 5, + "parents": [ + 72441 + ], + "children": [ + 72432, + 72431, + 72418 + ], + "area": 222056.25837000003, + "iscrowd": 0, + "segmentation": [], + "text": "The Multiregression Dynamic Model" + }, + { + "id": 72432, + "strid": "b38b4c5b-5142-4f9c-9c5d-473c4ab30027", + "image_id": 203324, + "image_name": "120050.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 62.078, + 1612.526, + 1059.606, + 171.80099999999993 + ], + "priority": 6, + "parents": [ + 72427 + ], + "children": [], + "area": 100102.389028, + "iscrowd": 0, + "segmentation": [], + "text": "The linear MDM is defined by equations shown in\nFigure 1 (top). Y,’ = (Y,(1),...,Y,(m)) is the time\nseries data at time t for n regions, and @((r) is the" + }, + { + "id": 72431, + "strid": "dd7eed71-1bda-4634-aeba-dfd9d09f0f03", + "image_id": 203324, + "image_name": "120050.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1241.865, + 391.411, + 1053.1230000000003, + 1380.079 + ], + "priority": 7, + "parents": [ + 72427 + ], + "children": [], + "area": 486079.621515, + "iscrowd": 0, + "segmentation": [], + "text": "vector of time-varying intercept and connectivity\nparameters; F,(r) are the “regressors” at time t, a\nvector comprised of the value 1 (for the intercept)\nand values of data for the parent nodes of region r\nat the current time t.\n\nNote that state space models do not assume\nnonstationarity, though when state covariance W,(r)\n= 0 for all t and r, the usual static regression model\nis obtained. When W,(r) is unknown, it can be\ndefined via a scalar discount factor (DF), such that\na DF=1 produces a static model. The conditional\nforecast distribution of Y,(r) given the past up to\ntime t-1 at its parents is a Student ¢ distribution, and\nthus the joint log predictive likelihood (LPL) can be\ncalculated as the sum of this distribution over\nnodes.\n\nFigure 2 (bottom) illustrates a 3-node DAG MDM,\nconsidering region / as the parent of region 2 and\nregion 3; and region 2 as the parent of region 3. The\norange ovals represent the (time-varying) effective\nconnectivity strength between two regions, the\npurple ovals the intercepts, and the blue circles the\nobservation noise." + }, + { + "id": 72418, + "strid": "3a2f5a52-b77f-435d-953f-b48844cc108d", + "image_id": 203324, + "image_name": "120050.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2316.399, + 391.854, + 1226.2069999999999, + 1469.895 + ], + "priority": 8, + "parents": [ + 72427 + ], + "children": [], + "area": 907690.213746, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 72428, + "strid": "774438bd-2b92-4912-a6f6-36ef4ef39634", + "image_id": 203324, + "image_name": "120050.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 95.796, + 1913.724, + 985.6679999999999, + 56.85799999999995 + ], + "priority": 9, + "parents": [ + 72441 + ], + "children": [ + 72433, + 72423, + 72422 + ], + "area": 183327.104304, + "iscrowd": 0, + "segmentation": [], + "text": "Searching the MDM using IPA and DGM" + }, + { + "id": 72433, + "strid": "c02a43ee-e5d1-421f-a076-9a258573037b", + "image_id": 203324, + "image_name": "120050.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 50.699, + 1993.728, + 1070.092, + 1260.154 + ], + "priority": 10, + "parents": [ + 72428 + ], + "children": [], + "area": 101080.015872, + "iscrowd": 0, + "segmentation": [], + "text": "First considering only acyclic models, we use an\nInteger Programming (IP) algorithm (gobnilp\nsystem; Bartlett and Cussens, 2013), to quickly find\nthe DAG with the optimal LPL; we call this the\nMDM-IPA model. Without the acyclic constraint, we\ncall our method a Directed Graph Model (MDM-\nDGM).\n\nFor instance consider a search problem for 3\nvariables. The Table 1 shows the local scores (LPL).\nThe MDM-DGM finds the directed graph that\nmaximizes the LPL for every node independently.\nTherefore, the best scoring model takes node / to\nhave no parents and the nodes 2 and 3 with the each\nother node plus node / as its parents, see Figure\n2(a). Note this is is a cyclic graph.\n\nThe MDM-IPA also considers the acyclic\nconstraints. Here, this constraint was violated in the\ncluster formed by nodes 2 and 3. The best solution\nleaves node 2 with the same set of parents as before,\nwhile node 3 becomes parentless; see Figure 2(b)." + }, + { + "id": 72423, + "strid": "a7245b80-e834-471b-9cc1-b5a8ad25ca06", + "image_id": 203324, + "image_name": "120050.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1247.983, + 1912.389, + 1048.9529999999997, + 976.55 + ], + "priority": 11, + "parents": [ + 72428 + ], + "children": [], + "area": 2386628.9613869996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 72422, + "strid": "71a822fe-751d-4e47-811f-f05b35655c24", + "image_id": 203324, + "image_name": "120050.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1248.732, + 2908.869, + 1049.817, + 469.8670000000002 + ], + "priority": 12, + "parents": [ + 72428 + ], + "children": [], + "area": 3632397.804108, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 72429, + "strid": "c846c6c0-60eb-4b2b-9674-2b4d61940770", + "image_id": 203324, + "image_name": "120050.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2626.775, + 1905.352, + 662.556, + 59.63000000000011 + ], + "priority": 13, + "parents": [ + 72441 + ], + "children": [ + 72437, + 72421, + 72419, + 72420, + 72436, + 72435, + 72434 + ], + "area": 5004930.9998, + "iscrowd": 0, + "segmentation": [], + "text": "The analysis of fMRI Data" + }, + { + "id": 72436, + "strid": "d95fc6be-2fc5-47e6-b4a4-cde01d8304d6", + "image_id": 203324, + "image_name": "120050.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2420.736, + 1985.284, + 1072.13, + 1365.6479999999997 + ], + "priority": 14, + "parents": [ + 72429 + ], + "children": [], + "area": 4805848.449024, + "iscrowd": 0, + "segmentation": [], + "text": "We analysed a rich fMRI study that have\ninformation for 5 steady-state acquisitions or\nsessions: Session 1 is a resting-state condition;\nsession 2 is a motor condition in which individuals\ntapped something; session 3 is a visual condition in\nwhich individuals watched a movie; session 4 and\nsession 5 are a combination between visual and\nmotor condition, but the former is in a random way\nwhilst in the latter, individuals tapping depending on\nrandom events in the movie. Data were acquired on\n15 subjects, and each acquisition consists of 230\ntime points, sampled every 1.3 seconds, with 2x2x2\nmm}? voxels. We use 11 ROI's defined on 5 motor\nbrain regions and 6 visual regions. The motor nodes\nused are Cerebellum, Putamen, Supplementary\nMotor Area (SMA), Precentral Gyrus and\nPostcentral Gyrus (nodes numbered from 1 to 5\nrespectively) whilst the visual nodes used are Visual\nCortex VI, V2, V3, V4, V5 and task negative\n(v1+v2; nodes numbered from 6 to 11 respectively).\nThe observed time series are computed as the\naverage of BOLD fMRI data over the voxels of each\nof these defined brain areas." + }, + { + "id": 72434, + "strid": "cad80408-312b-49a0-876f-4f044abdf88b", + "image_id": 203324, + "image_name": "120050.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 51.411, + 3422.95, + 1073.391, + 711.3140000000003 + ], + "priority": 15, + "parents": [ + 72429 + ], + "children": [], + "area": 175977.28245, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3 (top) shows the LPL versus discount factor\n(DF). Note that when DF=1 (a static model), it is\npossible to distinguish the estimated DAG (solid\nline) and a non-Markov equivalent (NME) DAG\n(dotdash line), but not the estimated DAG and a\nMarkov equivalent (ME) DAG (dotted line).\nMoreover, Figure 3 (below) gives the smoothed\nposterior mean with 95% HPD interval for\nconnectivity from Visual Cortex V2 to V1. As the\nDF for subject 1 (left; DF=0.67) is smaller than for\nsubject 8 (right; DF=0.80), the connection estimates\nare more dynamic for the former." + }, + { + "id": 72421, + "strid": "77c8c9f7-72da-45a9-a109-34886cfb078e", + "image_id": 203324, + "image_name": "120050.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 41.959, + 4156.095, + 1072.114, + 1027.3149999999996 + ], + "priority": 16, + "parents": [ + 72429 + ], + "children": [], + "area": 174385.590105, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 72435, + "strid": "e3bcec43-35fa-44af-9de1-ee5deee5f63d", + "image_id": 203324, + "image_name": "120050.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1233.68, + 3422.354, + 1073.075, + 532.656 + ], + "priority": 17, + "parents": [ + 72429 + ], + "children": [], + "area": 4222089.68272, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 4 shows the prevalence of the edge i9/, but\nonly for those edges with significant Binomial tests\nafter false discovery rate correction (FDR) at level\nO.epr—0.05, where i indexes rows and j columns. The\nnodes are ordered according to the expected flow of\ninformation in the brain, and thus it is notable that\nwe find significant edges between consecutive\nnodes. As expected, the significant MDM edges are\na subset of the significant partial correlations." + }, + { + "id": 72420, + "strid": "9e4a6937-133c-4b7d-892c-6eb19aac5166", + "image_id": 203324, + "image_name": "120050.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1159.266, + 3959.805, + 1223.5210000000002, + 1264.44 + ], + "priority": 18, + "parents": [ + 72429 + ], + "children": [], + "area": 4590467.30313, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 72419, + "strid": "c29baa28-07dd-4f1e-968f-3381a247885d", + "image_id": 203324, + "image_name": "120050.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2464.21, + 3417.121, + 1000.627, + 1327.5420000000004 + ], + "priority": 19, + "parents": [ + 72429 + ], + "children": [], + "area": 8420503.73941, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 72437, + "strid": "4ee4eaeb-d5bd-4cc0-b06d-7f1b5e75faf8", + "image_id": 203324, + "image_name": "120050.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2413.969, + 4763.849, + 1072.2709999999997, + 532.8919999999998 + ], + "priority": 20, + "parents": [ + 72429 + ], + "children": [], + "area": 11499783.806681002, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 5 shows the significant difference of the\nproportion of subjects who have a particular edge\nfor pairwise sessions using the MDM-DGM\nalgorithm. Most of difference between session | and\nother sessions is positive and so connections exist in\nresting-state but not in other experimental condition.\nIn general most of the difference between the\nsessions occurs in the connections between visual\nnodes (in the lower right square)." + }, + { + "id": 72440, + "strid": "a2daf820-ad5b-4112-99aa-f2a25fbaae9c", + "image_id": 203324, + "image_name": "120050.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1766.169, + 5501.641, + 1598.287, + 91.3100000000004 + ], + "priority": 21, + "parents": [ + 72441 + ], + "children": [], + "area": 9716827.783329, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements: CAPES - Coordenagao de Aperfeicoamento de Pessoal de Nivel Superior for\nfinancial support." + }, + { + "id": 72438, + "strid": "847a0a9b-d001-4799-a5f2-76c56517c5ed", + "image_id": 203324, + "image_name": "120050.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 56.539, + 5331.836, + 1630.46, + 218.89300000000003 + ], + "priority": 22, + "parents": [ + 72441 + ], + "children": [], + "area": 301456.67560400005, + "iscrowd": 0, + "segmentation": [], + "text": "References:\n\nBartlett M., Cussens J. (2013). Advances in Bayesian network learning using integer programming. In\nProceedings of the 29th Conference on Uncertainty in Artificial Intelligence (UAI 2013). AUAI Press.\nTo appear." + }, + { + "id": 72439, + "strid": "cd207e94-1e49-4664-a5d9-73d7f2e75df1", + "image_id": 203324, + "image_name": "120050.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1767.031, + 5327.377, + 1680.7349999999997, + 135.77000000000044 + ], + "priority": 23, + "parents": [ + 72441 + ], + "children": [], + "area": 9413640.307687001, + "iscrowd": 0, + "segmentation": [], + "text": "Costa L., Smith J.Q., Nichols T., Cussens J. (2013) Searching Multiregression Dynamic Models of Resting-\nState {MRI Networks using Integer Programming. CRiSM Res. Rep. (Submitted to Bayesian Analysis\nJournal)." + }, + { + "id": 43226, + "strid": "657411fe-4ac3-458a-a907-38515816e18e", + "image_id": 202192, + "image_name": "118313.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 718.78, + 368.86, + 208.75, + 186.05999999999995 + ], + "priority": -1, + "parents": [], + "children": [ + 43211, + 43207, + 43217, + 43223, + 43209, + 43224, + 43206, + 43213 + ], + "area": 265129.1908, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 43206, + "strid": "981446c9-92ba-4344-aaa6-9e49b7232106", + "image_id": 202192, + "image_name": "118313.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 694.765, + 55.588, + 2525.406, + 251.51400000000004 + ], + "priority": 1, + "parents": [ + 43226 + ], + "children": [], + "area": 38620.59682, + "iscrowd": 0, + "segmentation": [], + "text": "Pulmonary Embolism presented by syncope in a low-\nrisk patient: A case report" + }, + { + "id": 43207, + "strid": "7d16f171-f7f0-49fb-9c5f-80d5cc0f976a", + "image_id": 202192, + "image_name": "118313.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1069.928, + 366.852, + 1773.5089999999998, + 217.86400000000003 + ], + "priority": 2, + "parents": [ + 43226 + ], + "children": [], + "area": 392505.226656, + "iscrowd": 0, + "segmentation": [], + "text": "Amr A. A. Othman’, Aly M. Tohamy?, AymanK: M. Hassan?\n\n1. Medical Intern, Assiut University Faculty of Medicine, Assiut, Egypt\n2. Department of cardiovascular medicine, Assiut University Hospitals, Assiut, Egypt.\n3. Department-of.cardiovascular medicine, Vice-chairman of Assiut University Hospitals, Assiut, Egypt." + }, + { + "id": 43223, + "strid": "bb76f8f6-1287-4bf2-967b-d0e1bb11739c", + "image_id": 202192, + "image_name": "118313.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 539.254, + 705.585, + 262.22400000000005, + 42.04399999999998 + ], + "priority": 3, + "parents": [ + 43226 + ], + "children": [ + 43222 + ], + "area": 380489.53359, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 43222, + "strid": "7f281352-9752-4a0e-9771-2f565fcba5cd", + "image_id": 202192, + "image_name": "118313.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 45.785, + 776.396, + 1235.884, + 358.4839999999999 + ], + "priority": 4, + "parents": [ + 43223 + ], + "children": [], + "area": 35547.290859999994, + "iscrowd": 0, + "segmentation": [], + "text": "Pulmonary embolism (PE) is a medical emergency that can lead to sudden death. This\ncondition is usually preceded by some factors that may increase the risk of its occurrence,\nsuch as the age, high tendency of intravascular coagulation and presence of certain\nconcomitant conditions such as deep venous thrombosis (DVT) and malignancy. [1] In this\ncase, we have a presentation of a young, low-risk patient with only recurrent syncope and\ndyspnea that was eventually diagnosed as massive pulmonary embolism. It is an\nuncommon case of pulmonary embolism of unknown cause that deserves attention. Such a\ncommon presentation could lead to misdiagnosing the condition which could have ended\nultimately into sudden death of the patient." + }, + { + "id": 43224, + "strid": "74b0fcb4-92d1-4534-8e1a-f481723e2999", + "image_id": 202192, + "image_name": "118313.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 481.719, + 1157.009, + 372.868, + 44.25700000000006 + ], + "priority": 5, + "parents": [ + 43226 + ], + "children": [ + 43225, + 43218, + 43221, + 43216 + ], + "area": 557353.218471, + "iscrowd": 0, + "segmentation": [], + "text": "Case Presentation" + }, + { + "id": 43225, + "strid": "859f4c58-0a5c-422f-ae2c-9ff81c23c835", + "image_id": 202192, + "image_name": "118313.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 49.104, + 1215.65, + 1241.417, + 1438.3610000000003 + ], + "priority": 6, + "parents": [ + 43224 + ], + "children": [], + "area": 59693.2776, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 43221, + "strid": 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"parents": [ + 43218 + ], + "children": [], + "area": 2671681.040298, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1 (Left): Echocardiogram showing amass in the right\natrium: 2-D transthoracic echocardiography apical 4 chamber\nview shows a mass in the right atrium that protrudes through\nthe tricuspid valve (Arrow)." + }, + { + "id": 43216, + "strid": "622340de-42ea-4411-a966-cc2e3a55a32c", + "image_id": 202192, + "image_name": "118313.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1951.063, + 1111.084, + 566.2919999999999, + 243.78500000000008 + ], + "priority": 10, + "parents": [ + 43224 + ], + "children": [ + 43220 + ], + "area": 2167794.882292, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 43220, + "strid": "0ddcecba-9ae4-4ef2-9231-0f66a3fd7939", + "image_id": 202192, + "image_name": "118313.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1951.685, + 1477.383, + 556.134, + 102.84699999999998 + ], + "priority": 11, + "parents": [ + 43216 + ], + "children": [], + "area": 2883386.240355, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2 (Top): Multi-slice CT angiography showing massive\npulmonary embolism: Multi-slice CT pulmonary angiography\nshows massive bilateral pulmonary embolism involving the\nleft and the right pulmonary arteries (Asterisks)." + }, + { + "id": 43217, + "strid": "5aef8442-54e1-451d-b816-095fc0359a94", + "image_id": 202192, + "image_name": "118313.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1858.374, + 1631.666, + 219.66000000000008, + 40.631000000000085 + ], + "priority": 12, + "parents": [ + 43226 + ], + "children": [ + 43215, + 43208 + ], + "area": 3032245.671084, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion" + }, + { + "id": 43215, + "strid": "504d557d-440d-42a3-b79e-0900ae886796", + "image_id": 202192, + "image_name": "118313.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1346.68, + 1697.691, + 1241.778, 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Average testing set error rate and sparsity (in parentheses). Methods that\nlearn from the entire &-mer profile are shown in blue and methods that perform feature\nselection are shown in orange." + }, + { + "id": 190188, + "strid": "fbd9c15f-446a-41ce-857c-10e2aa9b062b", + "image_id": 207920, + "image_name": "9119.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3100.53, + 2360.532, + 1259.4389999999999, + 110.31800000000021 + ], + "priority": 38, + "parents": [ + 190175 + ], + "children": [], + "area": 7318900.281960001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190180, + "strid": "0eafcd62-167a-4cc8-8eb6-78d978c92840", + "image_id": 207920, + "image_name": "9119.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3099.45, + 2535.945, + 598.1660000000002, + 49.89300000000003 + ], + "priority": 39, + "parents": [ + 190175 + ], + "children": [], + "area": 7860034.73025, + "iscrowd": 0, + "segmentation": [], + "text": "The models are interpretable" + }, + { + "id": 190181, + "strid": "7462fcc5-44b1-4685-bccb-f57480b21c39", + "image_id": 207920, + "image_name": "9119.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3100.729, + 2642.068, + 1263.033, + 111.1840000000002 + ], + "priority": 40, + "parents": [ + 190175 + ], + "children": [], + "area": 8192336.867572, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190184, + "strid": "f4b80bb0-5db9-48b6-b192-7556c792b269", + "image_id": 207920, + "image_name": "9119.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3171.758, + 2793.44, + 1316.313, + 499.08399999999983 + ], + "priority": 41, + "parents": [ + 190175 + ], + "children": [ + 190182 + ], + "area": 8860115.66752, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190182, + "strid": "71e11e4a-2efb-4714-8d63-4305f08c5b15", + "image_id": 207920, + "image_name": "9119.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 3099.947, + 3333.429, + 1460.103, + 187.99400000000014 + ], + "priority": 42, + "parents": [ + 190184 + ], + "children": [], + "area": 10333453.228263, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 7: Six antibiotic resistance models (disjunctions). Rules are shown as circles\n(border: single=presence, double=absence). The circles contain the number of rules\nthat the SCM found to be equivalently predictive of the phenotype (equivalent rules).\nThe rule importances are shown on the edges." + }, + { + "id": 190186, + "strid": "11a3881f-6931-4e57-a9f1-2a58e0292df6", + "image_id": 207920, + "image_name": "9119.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3100.591, + 3586.447, + 448.3299999999999, + 50.041999999999916 + ], + "priority": 43, + "parents": [ + 190175 + ], + "children": [], + "area": 11120105.290177, + "iscrowd": 0, + "segmentation": [], + "text": "Going beyond k-mers" + }, + { + "id": 190187, + "strid": "d535ef1e-d9f4-46e1-b7e3-6b51153e59e0", + "image_id": 207920, + "image_name": "9119.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3100.585, + 3688.821, + 1461.1809999999996, + 93.0340000000001 + ], + "priority": 44, + "parents": [ + 190175 + ], + "children": [], + "area": 11437503.060285, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190185, + "strid": "b1cbae01-bcb5-4a8e-991c-a4fe9688ec6b", + "image_id": 207920, + "image_name": "9119.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3342.199, + 3781.986, + 965.8910000000001, + 474.53200000000015 + ], + "priority": 45, + "parents": [ + 190175 + ], + "children": [ + 190183 + ], + "area": 12640149.827214, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190183, + "strid": "0249a67c-16a6-4bae-9c85-1da03270c8a8", + "image_id": 207920, + "image_name": "9119.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 3100.691, + 4272.544, + 1459.9880000000003, + 183.96399999999994 + ], + "priority": 46, + "parents": [ + 190185 + ], + "children": [], + "area": 13247838.727904, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 8: The k-mers in the isoniazid model (rule and equivalent rules) are shown\non the katG gene. The k-mers all overlap a concise locus, suggesting the occurrence\nof a mutation. Interestingly, this locus contains codon 315 of KatG, where mutations\n$315G, S315l, S315N and S315T are all known to confer resistance to isoniazid." + }, + { + "id": 190170, + "strid": "8a3e32bc-cdf3-4493-b226-8ef380bd463b", + "image_id": 207920, + "image_name": "9119.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 574.468, + 3481.311, + 383.577, + 56.77799999999979 + ], + "priority": 47, + "parents": [ + 190196 + ], + "children": [ + 190191, + 190192, + 190190 + ], + "area": 1999901.767548, + "iscrowd": 0, + "segmentation": [], + "text": "eo Sea" + }, + { + "id": 190192, + "strid": "43882326-ea46-4087-a649-a6cdcf41ee73", + "image_id": 207920, + "image_name": "9119.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 36.279, + 3565.239, + 1414.841, + 286.53099999999995 + ], + "priority": 48, + "parents": [ + 190170 + ], + "children": [], + "area": 129343.30568100001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190191, + "strid": "7c975b36-823a-456f-b709-d46096464ab0", + "image_id": 207920, + "image_name": "9119.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 34.426, + 3885.832, + 1147.357, + 202.51499999999987 + ], + "priority": 49, + "parents": [ + 190170 + ], + "children": [], + "area": 133773.652432, + "iscrowd": 0, + "segmentation": [], + "text": "Paper\n\nDrouin et al. (2016). Predictive computational phenotyping and\nbiomarker discovery using reference-free genome comparisons.\nbioRxiv, 045153." + }, + { + "id": 190190, + "strid": "3bc522b6-440f-4d66-a98c-dcd322e3e9eb", + "image_id": 207920, + "image_name": "9119.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 33.924, + 4135.615, + 411.856, + 59.10900000000038 + ], + "priority": 50, + "parents": [ + 190170 + ], + "children": [], + "area": 140296.60326, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements" + }, + { + "id": 176668, + "strid": "9e4aa89f-8fcb-4add-9ebd-394aecf5637c", + "image_id": 207394, + "image_name": "8010.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 132.83, + 112.72, + 68.44999999999999, + 188.26000000000002 + ], + "priority": -1, + "parents": [], + "children": [ + 176648, + 176646, + 176645, + 176641, + 176647, + 176643, + 176642, + 176640, + 176644 + ], + "area": 14972.597600000001, + "iscrowd": 0, + "segmentation": [] + }, + { + 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behalf of the French register of ALS in Limousin (FRALim)" + }, + { + "id": 176648, + "strid": "c2d7a806-08b3-4678-aef3-84560a4f887c", + "image_id": 207394, + "image_name": "8010.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 69.88, + 507.996, + 296.791, + 55.014999999999986 + ], + "priority": 3, + "parents": [ + 176668 + ], + "children": [ + 176650, + 176649 + ], + "area": 35498.76048, + "iscrowd": 0, + "segmentation": [], + "text": "Background" + }, + { + "id": 176649, + "strid": "06673e84-69df-46a5-8e39-d5c18aa735e9", + "image_id": 207394, + "image_name": "8010.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 402.865, + 512.34, + 1656.24, + 50.672000000000025 + ], + "priority": 4, + "parents": [ + 176648 + ], + "children": [], + "area": 206403.85410000003, + "iscrowd": 0, + "segmentation": [], + "text": "The natural history of amyotrophic lateral sclerosis and patient risk stratifi-" + }, + { + "id": 176650, + "strid": 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"text": "Stuay location\n\nThe study was performed in Limousin, a region of\nFrance covering 16 942 km2\n\nIn 2011, Limousin's population was 741 100 inhabitant" + }, + { + "id": 176652, + "strid": "8989c6ed-d863-4c6f-afbf-5e8e5a3b8794", + "image_id": 207394, + "image_name": "8010.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 45.07, + 1384.087, + 1143.156, + 183.1980000000001 + ], + "priority": 10, + "parents": [ + 176643 + ], + "children": [], + "area": 62380.80109, + "iscrowd": 0, + "segmentation": [], + "text": "Eligibility criteria\nAll patients recruited in the FRALim register from\nJanuary 2000 to July 2013, were included" + }, + { + "id": 176653, + "strid": "f256a251-ccf3-4aa7-a1a5-65503429c469", + "image_id": 207394, + "image_name": "8010.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 42.139, + 1586.338, + 1149.018, + 444.0719999999999 + ], + "priority": 11, + "parents": [ + 176643 + ], + "children": [], + "area": 66846.69698200001, + "iscrowd": 0, + "segmentation": [], + "text": "Data collection, regulatory and ethical issues\n\nWe extracted socio-demographic and clinical data\ncollected in the register database\n\nVital status of patients was updated thanks to a query\nmade on November 2014 to the Centre de recherche\nen Epidémiologie et Santé des Populations of Inserm\n(U1018/CESP)" + }, + { + "id": 176660, + "strid": "d7982851-6801-4036-9553-01f03797aa90", + "image_id": 207394, + "image_name": "8010.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 43.975, + 2052.467, + 1147.409, + 1050.6600000000003 + ], + "priority": 12, + "parents": [ + 176643 + ], + "children": [], + "area": 90257.236325, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 176654, + "strid": "5382448b-f701-47f1-aca4-a31ed18e3c55", + "image_id": 207394, + "image_name": "8010.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 43.495, + 3118.292, + 1147.792, + 251.7420000000002 + ], + "priority": 13, + "parents": [ + 176643 + ], + "children": [], + "area": 135630.11054, + "iscrowd": 0, + "segmentation": [], + "text": "The honest tree was selected based on p-value infor-\nmation loss, defined as the likelihood ratio statistic\n(LRS) comparing a sub-tree with the largest tree in the\npruning sequence" + }, + { + "id": 176646, + "strid": "c4926ee2-335b-4920-9b25-edc6adffa16d", + "image_id": 207394, + "image_name": "8010.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1393.118, + 703.856, + 1155.5679999999998, + 54.346000000000004 + ], + "priority": 14, + "parents": [ + 176668 + ], + "children": [ + 176658, + 176667, + 176657, + 176666 + ], + "area": 980554.4630079999, + "iscrowd": 0, + "segmentation": [], + "text": "RESULTS : Patients recruited in FRALim register" + }, + { + "id": 176657, + "strid": "4f4763d9-f707-4774-abe6-aebdd334ca57", + "image_id": 207394, + "image_name": "8010.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1381.178, + 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Baseline characteristics of ALS patients" + }, + { + "id": 176667, + "strid": "16c3f9a9-3091-44a0-b78c-39b94901a4ad", + "image_id": 207394, + "image_name": "8010.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2168.502, + 877.022, + 1064.2670000000003, + 189.54200000000003 + ], + "priority": 19, + "parents": [ + 176646 + ], + "children": [], + "area": 1901823.961044, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 176647, + "strid": "d3741d01-49ae-4af5-9ec3-69d1e511e1c7", + "image_id": 207394, + "image_name": "8010.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2557.267, + 1140.054, + 689.3360000000002, + 48.625 + ], + "priority": 20, + "parents": [ + 176668 + ], + "children": [ + 176665, + 176663, + 176639 + ], + "area": 2915422.472418, + "iscrowd": 0, + "segmentation": [], + "text": "RESULTS: Risk stratification" + }, + { + "id": 176663, + "strid": "639a307a-6167-465a-9664-2e83c1e36ca4", + "image_id": 207394, + "image_name": "8010.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2160.192, + 1258.334, + 1092.0519999999997, + 1397.7279999999998 + ], + "priority": 21, + "parents": [ + 176647 + ], + "children": [ + 176664 + ], + "area": 2718243.040128, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 176664, + "strid": "7ae1ece1-f1b0-4b37-afdd-96c1339b2fa6", + "image_id": 207394, + "image_name": "8010.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1269.209, + 1942.306, + 842.0640000000001, + 345.84799999999996 + ], + "priority": 22, + "parents": [ + 176663 + ], + "children": [], + "area": 2465192.255954, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1 shows the results of the tree-based\nRECPAM analysis, where risk of death was stra-\ntified according to baseline characteristics\nThe algorithm identified four subgroups of\npatients at different mortality risks depending\non their baseline characteristics (ALSFRSR\nslope and EEDC-R category) and survival" + }, + { + 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54.427999999999884 + ], + "priority": 25, + "parents": [ + 176668 + ], + "children": [ + 176661, + 176662 + ], + "area": 3535393.732498, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion and Interpretation" + }, + { + "id": 176662, + "strid": "40894a00-17af-4788-a8ca-fcd77d5c4c93", + "image_id": 207394, + "image_name": "8010.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1419.212, + 2864.643, + 1801.5260000000003, + 585.8980000000001 + ], + "priority": 26, + "parents": [ + 176645 + ], + "children": [], + "area": 4065535.721316, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 176661, + "strid": "631af69d-6733-4809-abb9-54d959389c58", + "image_id": 207394, + "image_name": "8010.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1579.932, + 3573.272, + 1667.106, + 544.9870000000001 + ], + "priority": 27, + "parents": [ + 176645 + ], + "children": [], + "area": 5645526.777504, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 176644, + "strid": "e4906ebf-20e4-454f-96e3-dae95592105c", + "image_id": 207394, + "image_name": "8010.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 57.508, + 3416.626, + 269.591, + 42.384000000000015 + ], + "priority": 28, + "parents": [ + 176668 + ], + "children": [ + 176656, + 176655 + ], + "area": 196483.328008, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion" + }, + { + "id": 176655, + "strid": "bc348dce-8a1e-46d7-9f3a-299d2e20f0f1", + "image_id": 207394, + "image_name": "8010.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 51.175, + 3574.642, + 1280.832, + 289.96500000000015 + ], + "priority": 29, + "parents": [ + 176644 + ], + "children": [], + "area": 182932.30435, + "iscrowd": 0, + "segmentation": [], + "text": "The risk classification approach using RECPAM showed its\nability to separate subgroups with dramatically different\nprognosis.\n\nThis method could also be used to create a prognosis score\nin order to predict outcome based on baseline characteris-\nticse number of stratification factors to consider." + }, + { + "id": 176656, + "strid": "bb5a7fb9-2144-4a2a-b515-e8c3c25a1e55", + "image_id": 207394, + "image_name": "8010.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 51.108, + 3982.015, + 1393.82, + 599.4079999999999 + ], + "priority": 30, + "parents": [ + 176644 + ], + "children": [], + "area": 203512.82262, + "iscrowd": 0, + "segmentation": [], + "text": "Mitsumoto et al. (Lancet Neurol 2014) postulated that RCT in ALS\nhave been unsuccessful because of: enrolment of ALS patients at\nan advanced stage, the diversity and heterogeneity of the\ndisease, and an imbalance of patients between groups.\n\nAn accurate classification system based on characteristics and\nexpected survival could be of major interest to better control\nconfounding factors.\n\nThis would allow methodologists to stratify the randomization of\nRCT on the expected pattern of survival, and limit the number of\nstratification factors to consider.\n\nFurther research in this field could also help physicians to better\ndetermine the prognosis of ALS patients," + }, + { + "id": 8685, + "strid": "e881098b-2b43-4c3c-abc2-121ccd93c057", + "image_id": 200845, + "image_name": "11122.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 4271.14, + 97.96, + 236.39999999999964, + 231.15000000000003 + ], + "priority": -1, + "parents": [], + "children": [ + 8662, + 8663, + 8665, + 8664, + 8666, + 8673, + 8667 + ], + "area": 418400.87440000003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 8662, + "strid": "133388a5-d937-4f18-b5d0-78cfb38dd7bf", + "image_id": 200845, + "image_name": "11122.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 80.027, + 44.964, + 3948.674, + 388.585 + ], + "priority": 1, + "parents": [ + 8685 + ], + "children": [], + "area": 3598.3340279999998, + "iscrowd": 0, + "segmentation": [], + "text": "C: automatic prediction of quality and\ne visual reporting of MRI scans" + }, + { + "id": 8663, + "strid": "710c2dd6-a16d-4217-b4bd-68217d7fd471", + "image_id": 200845, + "image_name": "11122.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 32.556, + 482.016, + 4249.58, + 127.04400000000004 + ], + "priority": 2, + "parents": [ + 8685 + ], + "children": [], + "area": 15692.512896, + "iscrowd": 0, + "segmentation": [], + "text": "Oscar Esteban’, Krzysztof Gorgolewski?, Russell Poldrack’ - ‘Dept. of Psychology, Stanford University, US" + }, + { + "id": 8664, + "strid": "c5f24996-63eb-45a5-8a8b-b12e17f50d8e", + "image_id": 200845, + "image_name": "11122.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 40.118, + 718.005, + 710.604, + 458.45400000000006 + ], + "priority": 3, + "parents": [ + 8685 + ], + "children": [ + 8674, + 8677, + 8678, + 8668 + ], + "area": 28804.924590000002, + "iscrowd": 0, + "segmentation": [], + "text": "QA - ASSESSMENT\nQC - CONTROL\n\nVISUAL INSPECTION" + }, + { + "id": 8677, + "strid": "30b70dd9-f87c-4169-93e9-c2ea01d14c94", + "image_id": 200845, + "image_name": "11122.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 122.583, + 1213.665, + 652.603, + 589.1990000000001 + ], + "priority": 4, + "parents": [ + 8664 + ], + "children": [], + "area": 148774.696695, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 8674, + "strid": "205204b7-2bc1-4810-9b4c-0a848d8951f0", + "image_id": 200845, + "image_name": "11122.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 840.941, + 679.424, + 1045.352, + 333.62300000000005 + ], + "priority": 5, + "parents": [ + 8664 + ], + "children": [], + "area": 571355.497984, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 8668, + "strid": "b4f171cc-ba10-4150-9ca8-ade2bf3ac747", + "image_id": 200845, + "image_name": "11122.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 830.399, + 1091.478, + 1059.4300000000003, + 161.29700000000003 + ], + "priority": 6, + "parents": [ + 8664 + ], + "children": [], + "area": 906362.2397220001, + "iscrowd": 0, + "segmentation": [], + "text": "... IS time consuming, and prone\nto inter- and intra- rater variabilities" + }, + { + "id": 8678, + "strid": "765289c7-76d2-41e1-94c7-0e371d5f982d", + "image_id": 200845, + "image_name": "11122.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 925.193, + 1283.255, + 535.0730000000001, + 477.85400000000004 + ], + "priority": 7, + "parents": [ + 8664 + ], + "children": [], + "area": 1187258.543215, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 8666, + "strid": "f42dd47e-944b-4aaa-9bf2-f02773901e3f", + "image_id": 200845, + "image_name": "11122.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 741.008, + 1880.985, + 1087.012, + 85.34400000000005 + ], + "priority": 8, + "parents": [ + 8685 + ], + "children": [ + 8683, + 8669 + ], + "area": 1393824.93288, + "iscrowd": 0, + "segmentation": [], + "text": "AUTOMATED PREDICTION" + }, + { + "id": 8669, + "strid": "55c6e3be-2bb8-4606-85ab-cdcf0b26857c", + "image_id": 200845, + "image_name": "11122.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 86.712, + 2068.693, + 1758.928, + 624.6660000000002 + ], + "priority": 9, + "parents": [ + 8666 + ], + "children": [], + "area": 179380.50741600004, + "iscrowd": 0, + "segmentation": [], + "text": "Data: 1098 rs-fMRI scans from ABIDE [1], manual QA ratings (accept/reject)\nof two experts [2] (reject fractions - rater 1: 4.64%; rater 2: 5.83%).\n\nMethods: nested cross-validation (scikit-learn) with AUC (area under the\ncurve) scoring. Stratified 6-Fold split and grid search in the inner loop.\nOuter loop uses a stratified 5-Fold. Run permutation (5000 rep.) testing.\n\nModels: SVC (support vector machines classifier) and RFC (random-forests\nclassifier). Preprocessing: with and without site-wise standardization." + }, + { + "id": 8683, + "strid": "31ab3df2-145c-482a-93e2-628dd85b517d", + "image_id": 200845, + "image_name": "11122.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 86.993, + 2893.044, + 1736.985, + 199.95100000000002 + ], + "priority": 10, + "parents": [ + 8666 + ], + "children": [ + 8684 + ], + "area": 251674.57669199997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 8684, + "strid": "11f21547-fc82-4a67-8b5d-e3a5d1f01a6e", + "image_id": 200845, + "image_name": "11122.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 102.176, + 2817.994, + 1664.799, + 67.51299999999992 + ], + "priority": 11, + "parents": [ + 8683 + ], + "children": [], + "area": 287931.354944, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1. Cross-validation results. The best performing classifier was RFC-nzs, with the following hyperparameters (estimators/minimum samples per split/maximum\ndepth): rater 1 (18/2/5); and rater 2 (11/2/7). The reported score is roc_auc (area under the curve of the receiver-operator characteristic)." + }, + { + "id": 8665, + "strid": "b837d74d-30b1-4a72-9f21-b8675726f2e0", + "image_id": 200845, + "image_name": "11122.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3109.096, + 743.31, + 866.3980000000001, + 85.88599999999997 + ], + "priority": 12, + "parents": [ + 8685 + ], + "children": [ + 8676, + 8675 + ], + "area": 2311022.1477599996, + "iscrowd": 0, + "segmentation": [], + "text": "W/ DESIGN" + }, + { + "id": 8676, + "strid": "d824ab64-286f-43e1-b94c-1cdb6fdd057d", + "image_id": 200845, + "image_name": "11122.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2040.28, + 710.4, + 1037.046, + 1001.927 + ], + "priority": 13, + "parents": [ + 8665 + ], + "children": [], + "area": 1449414.912, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 8675, + "strid": "8b8ad635-a3cd-4d5b-81ac-3a32bf08f5af", + "image_id": 200845, + "image_name": "11122.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3120.102, + 852.356, + 1390.8720000000003, + 842.5930000000001 + ], + "priority": 14, + "parents": [ + 8665 + ], + "children": [], + "area": 2659437.6603119997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 8667, + "strid": "8c5485ca-889c-4d58-a26f-d9e2207e232d", + "image_id": 200845, + "image_name": "11122.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1992.13, + 1869.656, + 1665.7759999999998, + 102.36599999999999 + ], + "priority": 15, + "parents": [ + 8685 + ], + "children": [ + 8682, + 8671, + 8680, + 8681, + 8670, + 8679, + 8672 + ], + "area": 3724597.8072800003, + "iscrowd": 0, + "segmentation": [], + "text": "GROUP & INDIVIDUAL VISUAL REPORTS" + }, + { + "id": 8679, + "strid": "15b22b87-25ac-491b-8e67-6a4ad9f7a2bc", + "image_id": 200845, + "image_name": "11122.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1979.489, + 2052.028, + 823.3200000000002, + 901.0320000000002 + ], + "priority": 16, + "parents": [ + 8667 + ], + "children": [], + "area": 4061966.853692, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 8670, + "strid": "de8e151a-d813-4286-a171-ed53b80d05c8", + "image_id": 200845, + "image_name": "11122.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2025.552, + 2967.538, + 754.1800000000001, + 148.779 + ], + "priority": 17, + "parents": [ + 8667 + ], + "children": [], + "area": 6010902.530975999, + "iscrowd": 0, + "segmentation": [], + "text": "Group and individual reports\nMRIQC speeds up manual assessment with the\ncombination of group and individual reports." + }, + { + "id": 8680, + "strid": "4249a2e5-778b-47e9-a376-b66883a7618e", + "image_id": 200845, + "image_name": "11122.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2838.102, + 2065.733, + 1092.828, + 676.777 + ], + "priority": 18, + "parents": [ + 8667 + ], + "children": [], + "area": 5862760.958766, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 8671, + "strid": "bc045643-ef0c-4e80-869e-a2d2f9ef7f6c", + "image_id": 200845, + "image_name": "11122.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2922.702, + 2784.87, + 922.4319999999998, + 324.37300000000005 + ], + "priority": 19, + "parents": [ + 8667 + ], + "children": [], + "area": 8139345.118740001, + "iscrowd": 0, + "segmentation": [], + "text": "The fMRI summary plot\n\nIndividual reports consist of several sections that help\nevaluate different quality aspects. One section is the\nfMRI summary plot that shows the estimated head\nmotion, DVARS, spikes, etc. Other visual elements to aid\ninspection are mosaic views of volumes." + }, + { + "id": 8681, + "strid": "6b46de91-6ce2-4dcf-b6a3-7b5a4d3894c9", + "image_id": 200845, + "image_name": "11122.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3985.843, + 2068.983, + 597.116, + 319.96000000000004 + ], + "priority": 20, + "parents": [ + 8667 + ], + "children": [], + "area": 8246641.407669, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 8682, + "strid": "33e13358-fb50-4f00-a34c-b819e1ced4f3", + "image_id": 200845, + "image_name": "11122.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3986.986, + 2499.017, + 596.0199999999995, + 317.99800000000005 + ], + "priority": 21, + "parents": [ + 8667 + ], + "children": [], + "area": 9963545.792761998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 8672, + "strid": "a9a59db3-dbec-4713-925e-079bfafad0fe", + "image_id": 200845, + "image_name": "11122.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3992.573, + 2879.307, + 583.0130000000004, + 237.817 + ], + "priority": 22, + "parents": [ + 8667 + ], + "children": [], + "area": 11495843.386911, + "iscrowd": 0, + "segmentation": [], + "text": "Quality Assessment\n\nWe modified our reconstruction\nprotocol after discovering signal\nleakage from the eyes using MRIQC." + }, + { + "id": 8673, + "strid": "6b2f9aed-6ea4-4dbc-ab93-b22b75d0d13a", + "image_id": 200845, + "image_name": "11122.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 19.301, + 3187.389, + 1550.161, + 105.69300000000021 + ], + "priority": 23, + "parents": [ + 8685 + ], + "children": [], + "area": 61519.795089, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 67014, + "strid": "6ce89124-b46c-488d-b8ca-bbbcc451e86e", + "image_id": 203128, + "image_name": "119756.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 225.18, + 42.27, + 278.01, + 208.5 + ], + "priority": -1, + "parents": [], + "children": [ + 66996, + 66992, + 66998, + 66993, + 66995, + 66994, + 66997 + ], + "area": 9518.358600000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 66992, + "strid": "ad2052ca-56c9-4025-aeed-a2ff15fa8453", + "image_id": 203128, + "image_name": "119756.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 567.268, + 138.875, + 3667.3449999999993, + 112.52699999999999 + ], + "priority": 1, + "parents": [ + 67014 + ], + "children": [], + "area": 78779.3435, + "iscrowd": 0, + "segmentation": [], + "text": "Individual Differences in\\’Media Multitasking and Inattentional Blindness" + }, + { + "id": 66993, + "strid": "f6ee11c2-1677-467c-93f1-c73bce7d4b90", + "image_id": 203128, + "image_name": "119756.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1654.38, + 294.446, + 1493.766, + 184.74099999999999 + ], + "priority": 2, + "parents": [ + 67014 + ], + "children": [], + "area": 487125.5734800001, + "iscrowd": 0, + "segmentation": [], + "text": "D. Alexander Varakin.& Brian Huybers\n\nDepartment of Psychology,astern Kentucky University" + }, + { + "id": 66994, + "strid": "166b1c5e-3ab1-4bb5-aa80-37f33a211914", + "image_id": 203128, + "image_name": "119756.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 397.869, + 601.254, + 619.428, + 92.61299999999994 + ], + "priority": 3, + "parents": [ + 67014 + ], + "children": [ + 67000, + 67001, + 66999 + ], + "area": 239220.32772600002, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 66999, + "strid": "6ac9ae41-d362-4405-8e5f-80e183690f8c", + "image_id": 203128, + "image_name": "119756.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 75.371, + 815.41, + 1210.138, + 199.481 + ], + "priority": 4, + "parents": [ + 66994 + ], + "children": [], + "area": 61458.26710999999, + "iscrowd": 0, + "segmentation": [], + "text": "The cUrrent study investigated the relationship\nbetween media multitasking and inattentional\nblindness." + }, + { + "id": 67000, + "strid": "c16e32fb-c8bc-425a-aa84-bf7be53960e7", + "image_id": 203128, + "image_name": "119756.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 73.47, + 1108.636, + 1197.004, + 418.74400000000014 + ], + "priority": 5, + "parents": [ + 66994 + ], + "children": [], + "area": 81451.48692, + "iscrowd": 0, + "segmentation": [], + "text": "Media Multitasking: Using multiple forms of\nmedia at the same time. “Heavy” media\nmultitaskers (HMMs) are more susceptible to\ninterference from irrelevant stimuli than “light”\nmedia multitaskers(kMMs) on working memory\ntasks and visual Search? 2." + }, + { + "id": 67001, + "strid": "779dd1f7-86c9-4bf7-81af-b02e0dcf0117", + "image_id": 203128, + "image_name": "119756.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 72.921, + 1623.485, + 1224.78, + 426.12900000000013 + ], + "priority": 6, + "parents": [ + 66994 + ], + "children": [], + "area": 118386.149685, + "iscrowd": 0, + "segmentation": [], + "text": "Inattentional Blindness (IB): Failure to notice\nunexpected objects when attention is occupied\nwith something else?. Attentional set‘and task\ndifficulty are important determinants-of |B*°.\nIndividual differences variables. have been harder\nto pin down>®." + }, + { + "id": 66997, + "strid": "bb137241-9a19-42d2-82fd-a7dfc6572bfe", + "image_id": 203128, + "image_name": "119756.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 361.806, + 2149.044, + 693.2239999999999, + 112.18899999999985 + ], + "priority": 7, + "parents": [ + 67014 + ], + "children": [ + 67002 + ], + "area": 777537.013464, + "iscrowd": 0, + "segmentation": [], + "text": "Current, Study" + }, + { + "id": 67002, + "strid": "6bbd463f-a168-4c60-9be6-b43ff0a8995d", + "image_id": 203128, + "image_name": "119756.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 73.629, + 2361.308, + 1253.167, + 1086.951 + ], + "priority": 8, + "parents": [ + 66997 + ], + "children": [], + "area": 173860.746732, + "iscrowd": 0, + "segmentation": [], + "text": "If HMMs arecmore susceptible to interference\nfrom task-irrelevant stimuli than LMMs, would\nHMMs bemore likely to notice the unexpected\nobject-in an inattention task?\n\nNoticing an unexpected object may be preceded\nby attention capture, but attentioncapture might\nnot be sufficient for awareness* Thus, past\nresearch demonstrating that44MMs are more\nsusceptible to capture do not necessarily imply\nthat HMMs are moreNikely to become aware of\nirrelevant stimuli.\n\nThe current experiment assessed the\nrelationship between self-reported media\nmultitasking’and IB, as indexed using Mack~and\nRock’s(paradigm." + }, + { + "id": 66995, + "strid": "bfb578c6-8033-45b9-8c77-1d642b8e9622", + "image_id": 203128, + "image_name": "119756.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2202.697, + 600.446, + 395.942, + 93.029 + ], + "priority": 9, + "parents": [ + 67014 + ], + "children": [ + 67005, + 67004, + 67008, + 67010, + 67009 + ], + "area": 1322600.6028620002, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 67004, + "strid": "1a7e755d-e681-437d-af47-d9399597acb0", + "image_id": 203128, + "image_name": "119756.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1433.185, + 807.318, + 260.3890000000001, + 48.58899999999994 + ], + "priority": 10, + "parents": [ + 66995 + ], + "children": [], + "area": 1157036.0478299998, + "iscrowd": 0, + "segmentation": [], + "text": "Procedure" + }, + { + "id": 67005, + "strid": "8fd1de1e-8946-4cf9-8ca4-f8a65425f7cd", + "image_id": 203128, + "image_name": "119756.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1430.173, + 953.913, + 1927.238, + 778.038 + ], + "priority": 11, + "parents": [ + 66995 + ], + "children": [], + "area": 1364260.616949, + "iscrowd": 0, + "segmentation": [], + "text": "Media Use Questionnaire. For each of 10 primary media‘items, participants indicated\nhow many hours per week they used the medium, and the proportion of time spent engaged\nwith each of the 9 other media. The Media Multitasking tMdex (MMI) was created by summing\nthe numbefof hours using each primary media weighted by the proportion of time spent using\nother media, and dividing by the total amount of time spent using any media??. It indexes the\nlevel ofymultitasking during a self-reported typicalhour.\n\nSimilar to Ophir et al., participants were-divided into groups based on MMI scores.\nLMM: Light Media Multitasker = MMI'<1SD below mean MMI (n= 12)\n\nHMM: Heavy Media Multitasker = MMI >1SD above mean MMI (n= 14)\n\nIn addition, we divided the middle of the distribution:\n\nMLMM: 1SD below mean < MMI < Mean (n = 41)\n\nHLMM: Mean < MMI < 1SD’above mean (n = 28)" + }, + { + "id": 67008, + "strid": "6fdcfe7d-458e-4f69-8fc6-fba561ad9c92", + "image_id": 203128, + "image_name": "119756.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1432.02, + 1819.584, + 1890.2310000000002, + 58.29299999999989 + ], + "priority": 12, + "parents": [ + 66995 + ], + "children": [], + "area": 2605680.67968, + "iscrowd": 0, + "segmentation": [], + "text": "Inattentional Blindness Task: Based on Mack and Rock’s (1998) experiments" + }, + { + "id": 67009, + "strid": "cce2893b-e033-4d16-bf98-dc022e8c0feb", + "image_id": 203128, + "image_name": "119756.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1435.764, + 1914.95, + 1853.3149999999998, + 686.3120000000001 + ], + "priority": 13, + "parents": [ + 66995 + ], + "children": [], + "area": 2749416.2717999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 67010, + "strid": "a8af3a8f-6cc4-4dc1-9152-9aeb1c0a5ccd", + "image_id": 203128, + "image_name": "119756.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1432.966, + 2710.64, + 1858.6479999999997, + 882.973 + ], + "priority": 14, + "parents": [ + 66995 + ], + "children": [], + "area": 3884254.9582399996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 66996, + "strid": "d371acb6-1b85-4592-bd69-4cb5bd8d4eac", + "image_id": 203128, + "image_name": "119756.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3899.479, + 598.965, + 357.7739999999999, + 94.33399999999995 + ], + "priority": 15, + "parents": [ + 67014 + ], + "children": [ + 67011, + 67007, + 67006, + 67013, + 67012 + ], + "area": 2335651.439235, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 67007, + "strid": "e59a3207-19d3-4df5-ba27-a2ff55d448bb", + "image_id": 203128, + "image_name": "119756.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3454.359, + 797.177, + 452.2829999999999, + 57.56299999999999 + ], + "priority": 16, + "parents": [ + 66996 + ], + "children": [], + "area": 2753735.544543, + "iscrowd": 0, + "segmentation": [], + "text": "MMI Distribution" + }, + { + "id": 67011, + "strid": "299a5d8c-0172-4932-8600-0e44caf76114", + "image_id": 203128, + "image_name": "119756.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3456.006, + 889.472, + 633.4679999999998, + 435.3030000000001 + ], + "priority": 17, + "parents": [ + 66996 + ], + "children": [], + "area": 3074020.568832, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 67013, + "strid": "32a73d18-fae1-40e3-b3d1-a2f5d7e179dd", + "image_id": 203128, + "image_name": "119756.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4107.141, + 905.318, + 438.6139999999996, + 223.65300000000002 + ], + "priority": 18, + "parents": [ + 66996 + ], + "children": [], + "area": 3718268.6758379997, + "iscrowd": 0, + "segmentation": [], + "text": "Mean = 2.20*\nSD = 1.27\n\n*significantly lower than Ophir’s" + }, + { + "id": 67006, + "strid": "978104f5-16a4-43db-a517-bee70f1df27c", + "image_id": 203128, + "image_name": "119756.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3472.156, + 1432.207, + 600.6710000000003, + 57.90300000000002 + ], + "priority": 19, + "parents": [ + 66996 + ], + "children": [], + "area": 4972846.128292, + "iscrowd": 0, + "segmentation": [], + "text": "IB Results x MMLGroup" + }, + { + "id": 67012, + "strid": "034db99d-da30-486c-b479-7164eab1039d", + "image_id": 203128, + "image_name": "119756.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3455.077, + 1535.798, + 1158.8940000000002, + 1114.7030000000002 + ], + "priority": 20, + "parents": [ + 66996 + ], + "children": [], + "area": 5306300.346446, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 66998, + "strid": "901e49ba-9ae0-457f-8485-b35abf3d9154", + "image_id": 203128, + "image_name": "119756.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3784.034, + 2697.52, + 593.4760000000001, + 92.88000000000011 + ], + "priority": 21, + "parents": [ + 67014 + ], + "children": [ + 67003 + ], + "area": 10207507.395680001, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 67003, + "strid": "53038876-619e-4248-b97c-8cfdd262eee0", + "image_id": 203128, + "image_name": "119756.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3469.062, + 2886.877, + 1216.335, + 417.4789999999998 + ], + "priority": 22, + "parents": [ + 66998 + ], + "children": [], + "area": 10014755.299374, + "iscrowd": 0, + "segmentation": [], + "text": "The current results suggest the relationship\nbetween self-reported media multitasking and IB\nis not very large. Current study lacked statistical\npower to detect medium and small effects.\nRange of MM|lscores limited compared to other\nstudies." + }, + { + "id": 142293, + "strid": "85bfdc00-dee5-405e-852a-58c2bfc448f2", + "image_id": 206030, + "image_name": "17030.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 552.41, + 43.95, + 121.63, + 185.32999999999998 + ], + "priority": -1, + "parents": [], + "children": [ + 142287, + 142286, + 142288, + 142285 + ], + "area": 24278.4195, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 142285, + "strid": "d3b7e1fa-d5e9-4cdc-b7a8-6c307cfdadf1", + "image_id": 206030, + "image_name": "17030.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 716.016, + 62.554, + 3835.9639999999995, + 94.96799999999999 + ], + "priority": 1, + "parents": [ + 142293 + ], + "children": [], + "area": 44789.664864, + "iscrowd": 0, + "segmentation": [], + "text": "SwissBioPics — an interactive library of cell images for the visualization of subcellular location data." + }, + { + "id": 142286, + "strid": "1e01ffbb-e43f-4f3d-8079-5112d16b23f6", + "image_id": 206030, + "image_name": "17030.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 721.862, + 181.101, + 3917.1189999999997, + 229.74900000000002 + ], + "priority": 2, + "parents": [ + 142293 + ], + "children": [], + "area": 130729.930062, + "iscrowd": 0, + "segmentation": [], + "text": "Philippe Le Mercier, Jerven Bolleman, Edouard de Castro, Parit Bansal, Elisabeth Gasteiger, Andrea Auchincloss, Emmanuel Boutet, Lionel Breuza, Cristina Casals\nCasas, Anne Estreicher, Marc Feuermann, Damien Lieberherr, Catherine Rivoire, lvo Pedruzzi, Nicole Redaschi, and Alan Bridge\nSwiss-Prot group, SIB Swiss Institute of Bioinformatics, 1 Michel Servet, Geneva, Switzerland" + }, + { + "id": 142287, + "strid": "1610dc0b-bf80-4b2a-ac8c-d38f21052c7e", + "image_id": 206030, + "image_name": "17030.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 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"image_name": "17030.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2060.986, + 1693.691, + 2595.527, + 768.6850000000002 + ], + "priority": 8, + "parents": [ + 142288 + ], + "children": [], + "area": 3490673.439326, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 15628, + "strid": "74be3f0c-6708-4a81-9428-db5794a45adb", + "image_id": 201114, + "image_name": "116622.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 35.72, + 29.08, + 44.64, + 68.22 + ], + "priority": -1, + "parents": [], + "children": [ + 15602, + 15625, + 15603, + 15600, + 15598, + 15597, + 15601, + 15599 + ], + "area": 1038.7376, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 15597, + "strid": "1ddf8a09-a47f-473f-9571-7abb676b4b73", + "image_id": 201114, + "image_name": "116622.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 93.057, + 46.891, + 648.518, + 58.45600000000001 + ], + "priority": 1, + "parents": [ + 15628 + ], + "children": [], + "area": 4363.535787, + "iscrowd": 0, + "segmentation": [], + "text": "Effects of closure on the processing of invisible figures:\nAn ERP study" + }, + { + "id": 15598, + "strid": "f650e517-c3e4-4ea0-a79c-6db4162c7905", + "image_id": 201114, + "image_name": "116622.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 104.767, + 105.91, + 626.904, + 32.952 + ], + "priority": 2, + "parents": [ + 15628 + ], + "children": [], + "area": 11095.872969999999, + "iscrowd": 0, + "segmentation": [], + "text": "Weina Zhu®* & Yuanye Ma’\n4¥unnan Univérsity, Kunming, China, Kunming Inistitute of Zoology, Chinese Academly Of Science, Kunming, China" + }, + { + "id": 15599, + "strid": "b569a019-4854-438b-a286-df149453179b", + "image_id": 201114, + "image_name": "116622.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 165.38, + 169.311, + 83.11700000000002, + 13.211000000000013 + ], + "priority": 3, + "parents": [ + 15628 + ], + "children": [ + 15604 + ], + "area": 28000.65318, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 15604, + "strid": "26f5fba1-d98e-4fcf-8a9a-f6e445a131e9", + "image_id": 201114, + "image_name": "116622.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 21.625, + 194.591, + 370.811, + 124.20400000000001 + ], + "priority": 4, + "parents": [ + 15599 + ], + "children": [], + "area": 4208.030375, + "iscrowd": 0, + "segmentation": [], + "text": "‘The specific nature of closure is important for the computation of an\nobject representation. The discrimination of closuie is typically faster\nand easier than that of other geometrical features (Pomerantz, Sager\net al. 1977; Treisman and Paterson 1984).\n\nIn order’ to investigate whether the specific nature of closure\nrequires conscious perception, we recorded Event-Related Potentials\n(ERPs) during a Continuous Flashed Suppression paradigm (CFS)\n(Tsuchiya and Koch 2005)" + }, + { + "id": 15601, + "strid": "e00d6fae-d9eb-455a-afb1-c147ead21f3e", + "image_id": 201114, + "image_name": "116622.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 177.863, + 326.672, + 59.56, + 13.728999999999985 + ], + "priority": 5, + "parents": [ + 15628 + ], + "children": [ + 15610, + 15606, + 15605, + 15607, + 15608, + 15627 + ], + "area": 58102.861936, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 15605, + "strid": "ca281dd3-3696-495c-b6df-a70d59c1bdd7", + "image_id": 201114, + "image_name": "116622.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 21.001, + 358.1, + 371.424, + 69.50400000000002 + ], + "priority": 6, + "parents": [ + 15601 + ], + "children": [], + "area": 7520.458100000001, + "iscrowd": 0, + "segmentation": [], + "text": "Continuous Flash Supeisssion paradiga (CFS)\n\nStimuli: six pairs of well controlled figures were used as target stimuli,\nand one of the two figures in each pair is closed (Zhu, Zhang et al\n2012)." + }, + { + "id": 15606, + "strid": "39d221e9-86c3-4c61-be69-0b9d67c4d6e9", + "image_id": 201114, + "image_name": "116622.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 21.886, + 432.474, + 367.44, + 51.79599999999999 + ], + "priority": 7, + "parents": [ + 15601 + ], + "children": [], + "area": 9465.125963999999, + "iscrowd": 0, + "segmentation": [], + "text": "Procedure: target stimuli and a flashedMondrian pattern were\ndisplayed separately in two eyes of the’ subjects. Subjects were\ngisttucted to respond when they seed of the figures." + }, + { + "id": 15607, + "strid": "7b594e9b-9e56-44dc-b278-a87ad2c140cb", + "image_id": 201114, + "image_name": "116622.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 20.558, + 489.582, + 368.768, + 91.63900000000001 + ], + "priority": 8, + "parents": [ + 15601 + ], + "children": [], + "area": 10064.826756, + "iscrowd": 0, + "segmentation": [], + "text": "Rehevices! Experiment : Maid\nThe intensity of the target stimuli were changed from low to high\nduring the experiment, and the stimuli and flashed masks were on\nthe screen until the subjects responded. The reaction time and\naccuracy of the subjects were analyzed." + }, + { + "id": 15627, + "strid": "df262c75-54e4-4bc7-bce3-b029eea314e4", + "image_id": 201114, + "image_name": "116622.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 20.991, + 590.966, + 124.687, + 13.724000000000046 + ], + "priority": 9, + "parents": [ + 15601 + ], + "children": [], + "area": 12404.967306, + "iscrowd": 0, + "segmentation": [], + "text": "ERP Experiment : N=24" + }, + { + "id": 15608, + "strid": "6afd2d52-0ad4-4e1e-b518-5630d1e2b977", + "image_id": 201114, + "image_name": "116622.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 21.562, + 610.769, + 368.649, + 237.39999999999998 + ], + "priority": 10, + "parents": [ + 15601 + ], + "children": [], + "area": 13169.401178, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 15610, + "strid": "c39e47c3-d8b1-4636-a45e-51fc8a00d65f", + "image_id": 201114, + "image_name": "116622.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 20.988, + 848.324, + 378.77, + 123.37599999999998 + ], + "priority": 11, + "parents": [ + 15601 + ], + "children": [], + "area": 17804.624111999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 15600, + "strid": "51f64107-90af-49f5-a96f-d38e5a5143b1", + "image_id": 201114, + "image_name": "116622.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 594.746, + 168.738, + 47.745000000000005, + 13.900000000000006 + ], + "priority": 12, + "parents": [ + 15628 + ], + "children": [ + 15614, + 15620, + 15617, + 15613, + 15619, + 15618, + 15621, + 15615, + 15622, + 15616, + 15624, + 15623 + ], + "area": 100356.250548, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 15620, + "strid": "0ed4a391-9560-4862-8e9c-5d4e9258cc5a", + "image_id": 201114, + "image_name": "116622.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 442.096, + 193.839, + 102.85000000000002, + 10.877999999999986 + ], + "priority": 13, + "parents": [ + 15600 + ], + "children": [], + "area": 85695.446544, + "iscrowd": 0, + "segmentation": [], + "text": "Behavioral Experiment" + }, + { + "id": 15618, + "strid": "44587afd-dd26-4c4a-90e0-50c18b5a558a", + "image_id": 201114, + "image_name": "116622.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 478.164, + 212.829, + 249.23699999999997, + 91.76400000000001 + ], + "priority": 14, + "parents": [ + 15600 + ], + "children": [], + "area": 101767.165956, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 15619, + "strid": "a11b8b26-a721-4df9-9d2f-256f8d3822df", + "image_id": 201114, + "image_name": "116622.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 655.176, + 251.12, + 128.08399999999995, + 44.50400000000002 + ], + "priority": 15, + "parents": [ + 15600 + ], + "children": [], + "area": 164527.79712, + "iscrowd": 0, + "segmentation": [], + "text": "Cleeed figaves took tess tine tobe\n(677m. 1953 ms ota\nbetter accuracy (99.1% vs.97 94." + }, + { + "id": 15617, + "strid": "4f7abf6c-c2e2-41ec-bd13-9f337be2ebaa", + "image_id": 201114, + "image_name": "116622.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 431.522, + 313.8, + 363.796, + 123.56099999999998 + ], + "priority": 16, + "parents": [ + 15600 + ], + "children": [], + "area": 135411.6036, + "iscrowd": 0, + "segmentation": [], + "text": "ERP Experiment :\nthree areas: Occipital (02, 01, 02 and POZ}, Left Temporal-Occipital\n(1P7, POS, PO7, PS, P7, CB1) and Right Temporal-Occipital (TP8, POE,\nPOB, P6, P8, CB2) areas were analyzed,\n\n-the peak latency showed that closed figures (237ms) had shorter\nlatency than open figures (244ms).This was reflected in the\nbehavioral results.\n\nAnalysis of the area amplitude between 200ms and 300ms:" + }, + { + "id": 15621, + "strid": "ed7d7a19-1d0b-44e1-bb1d-847c53490d80", + "image_id": 201114, + "image_name": "116622.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 441.007, + 445.997, + 53.488999999999976, + 9.506000000000029 + ], + "priority": 17, + "parents": [ + 15600 + ], + "children": [], + "area": 196687.798979, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 15615, + "strid": "4b0dbc68-7880-4f75-8943-89e9120676e5", + "image_id": 201114, + "image_name": "116622.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 440.998, + 456.385, + 359.372, + 109.66700000000003 + ], + "priority": 18, + "parents": [ + 15600 + ], + "children": [], + "area": 201264.87222999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 15616, + "strid": "26be7e6b-5c67-47cb-80e3-36b3765d8b23", + "image_id": 201114, + "image_name": "116622.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 472.688, + 568.928, + 311.274, + 21.936000000000035 + ], + "priority": 19, + "parents": [ + 15600 + ], + "children": [], + "area": 268925.438464, + "iscrowd": 0, + "segmentation": [], + "text": "Crgneiale! sane, nn Mgaificent cainrace Retna pees and chen Rewres on\nGtr concious and unconscious conditions." + }, + { + "id": 15622, + "strid": "e58fee86-f7c9-480e-a3af-238d11255223", + "image_id": 201114, + "image_name": "116622.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 437.832, + 602.683, + 107.96400000000006, + 10.729000000000042 + ], + "priority": 20, + "parents": [ + 15600 + ], + "children": [], + "area": 263873.903256, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 15614, + "strid": "5fb97668-e0ba-4484-a820-3284fd82b9fc", + "image_id": 201114, + "image_name": "116622.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 439.136, + 616.106, + 360.434, + 108.11599999999999 + ], + "priority": 21, + "parents": [ + 15600 + ], + "children": [], + "area": 270554.324416, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 15623, + "strid": "b073a564-0655-45b5-9997-65e18ef2c54c", + "image_id": 201114, + "image_name": "116622.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 437.623, + 722.235, + 113.20400000000001, + 10.90300000000002 + ], + "priority": 22, + "parents": [ + 15600 + ], + "children": [], + "area": 316066.647405, + "iscrowd": 0, + "segmentation": [], + "text": "Right Ternporal-Occipital area" + }, + { + "id": 15624, + "strid": "72084dfb-27ad-4d3b-a8dd-cdabf08105c9", + "image_id": 201114, + "image_name": "116622.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 444.493, + 737.76, + 352.613, + 97.71600000000001 + ], + "priority": 23, + "parents": [ + 15600 + ], + "children": [], + "area": 327929.15567999997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 15613, + "strid": "efbe2419-03c8-4b32-9245-9115ae445ac0", + "image_id": 201114, + "image_name": "116622.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 458.142, + 848.699, + 322.715, + 34.96100000000001 + ], + "priority": 24, + "parents": [ + 15600 + ], + "children": [], + "area": 388824.657258, + "iscrowd": 0, + "segmentation": [], + "text": "Di the teENpOrEL- corti erenn, Kina cineed guns Inckiced! Mager eapateee\nthan open gues visible gues induced oppose resus: dosed figures induced\nsmaller amplitude then opap teres." + }, + { + "id": 15603, + "strid": "1af77f84-8d90-44ee-8a67-7b1b249c81c2", + "image_id": 201114, + "image_name": "116622.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 579.205, + 897.124, + 77.93999999999994, + 14.200000000000045 + ], + "priority": 25, + "parents": [ + 15628 + ], + "children": [ + 15611, + 15612 + ], + "area": 519618.70642000006, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 15612, + "strid": "911afefb-37d5-4d8b-89ea-c3f61f4af93b", + "image_id": 201114, + "image_name": "116622.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 432.93, + 928.033, + 354.98599999999993, + 42.01999999999998 + ], + "priority": 26, + "parents": [ + 15603 + ], + "children": [], + "area": 401773.32669, + "iscrowd": 0, + "segmentation": [], + "text": "Our results indikate that closure can be processed 4A the absence of\nawareness, and show a perceptional advantage of closed figures in\nboth behavioral and ERP results." + }, + { + "id": 15611, + "strid": "8e0a3c9a-b7f7-493d-a9aa-b7edc0dc4b1f", + "image_id": 201114, + "image_name": "116622.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 445.032, + 973.079, + 351.28799999999995, + 92.10799999999995 + ], + "priority": 27, + "parents": [ + 15603 + ], + "children": [], + "area": 433051.29352799995, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 15625, + "strid": "86e663d1-a010-47ad-ad0a-9848c9e64ee8", + "image_id": 201114, + "image_name": "116622.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 429.157, + 1073.024, + 94.666, + 11.814000000000078 + ], + "priority": 28, + "parents": [ + 15628 + ], + "children": [ + 15626 + ], + "area": 460495.7607679999, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements:" + }, + { + "id": 15626, + "strid": "b87e6c61-f044-42ce-a9b1-b20eca43e32f", + "image_id": 201114, + "image_name": "116622.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 428.376, + 1086.756, + 374.31999999999994, + 37.66399999999999 + ], + "priority": 29, + "parents": [ + 15625 + ], + "children": [], + "area": 465540.188256, + "iscrowd": 0, + "segmentation": [], + "text": "Tee prodect wee eupportg is is Metionsl Neture Science Reundation of Cire (ELAgROE2,\n61005087), Yunnan Science and Technology Project (20090018), Yunnan Eduction\nDeparement Kay Progatenigone7)" + }, + { + "id": 15602, + "strid": "41b2c472-3132-47f4-8251-85ea9aeaf517", + "image_id": 201114, + "image_name": "116622.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 174.164, + 988.722, + 71.779, + 14.104000000000042 + ], + "priority": 30, + "parents": [ + 15628 + ], + "children": [ + 15609 + ], + "area": 172199.77840799998, + "iscrowd": 0, + "segmentation": [], + "text": "3c) ict ecd sleek" + }, + { + "id": 15609, + "strid": "a7ab2a21-30f5-41bb-a73e-70fdec94f72f", + "image_id": 201114, + "image_name": "116622.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 22.774, + 1016.388, + 373.602, + 93.351 + ], + "priority": 31, + "parents": [ + 15602 + ], + "children": [], + "area": 23147.220312, + "iscrowd": 0, + "segmentation": [], + "text": "Pomerantz, J. R., L. C. Sager, et al. (1977).<\"Perception of wholes and of their\ncomponent parts: some configural superiority effects.\" Exp Psychol Hum Percept\nPerform 3(3): 422-435,\n\nTreisman, A. and R. Paterson (1984)°\"Emergent features, attention, and objett\nperception.” E49 Peychol Hum Percept Perform 20(1): 12-31,\n\nZhu, W., J. Zhang, et al. (accepted). \"The time course ofthe perceptual processing\n\nof “hole” and “no-hole” figures! An ERP study.\" Neurosci Bull" + }, + { + "id": 126511, + "strid": "c4ae8c61-c864-4322-9a9d-d5222cbba50c", + "image_id": 205428, + "image_name": "15115.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 2947.72, + 555.73, + 293.3900000000003, + 203.74 + ], + "priority": -1, + "parents": [], + "children": [ + 126501, + 126503, + 126500, + 126502, + 126499, + 126498 + ], + "area": 1638136.4356, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 126498, + "strid": "aee954bb-a071-4ad7-b863-481dbce126d6", + "image_id": 205428, + "image_name": "15115.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 89.102, + 74.179, + 2421.256, + 537.175 + ], + "priority": 1, + "parents": [ + 126511 + ], + "children": [], + "area": 6609.497258, + "iscrowd": 0, + "segmentation": [], + "text": "Business models in ia)\nbio-data Bee See" + }, + { + "id": 126499, + "strid": "effeb82b-f7ae-4e5a-a916-512dd9dc6635", + "image_id": 205428, + "image_name": "15115.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 94.299, + 628.582, + 1686.509, + 58.80600000000004 + ], + "priority": 2, + "parents": [ + 126511 + ], + "children": [], + "area": 59274.654018, + "iscrowd": 0, + "segmentation": [], + "text": "Katharina B. Lauer, Sirkka Jarvenpaa, Anna Penninger, Hannes Rothe" + }, + { + "id": 126503, + "strid": "fd4b831b-b971-4843-b235-247fbb5aecd9", + "image_id": 205428, + "image_name": "15115.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 80.155, + 795.746, + 3082.371, + 591.2030000000001 + ], + "priority": 3, + "parents": [ + 126511 + ], + "children": [], + "area": 63783.02063, + "iscrowd": 0, + "segmentation": [], + "text": "Improvements in technology and a decline in the price of generating data has led to a surge in the amount of data\navailable for life-science research. Many stakeholders active in this ecosystem, especially publicly funded institutions,\ndeposit these data into openly available databases where they can be accessed freely. These openly available data\nresources act as a source for innovation from researchers in academia and industry alike. Appropriation of value from\nthese public databases can be achieved through employing various different.\n\nWe seek to understand how Small and Medium Size Enterprises active in the life science ecosystem generate value\nfrom this open data through deploying various business models and investigate the constraints they face when using\nopen data resources." + }, + { + "id": 126500, + "strid": "60f75126-a037-40ab-9a9d-71efa1ea63d7", + "image_id": 205428, + "image_name": "15115.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 90.368, + 1481.991, + 1638.21, + 191.08500000000004 + ], + "priority": 4, + "parents": [ + 126511 + ], + "children": [ + 126504, + 126509 + ], + "area": 133924.562688, + "iscrowd": 0, + "segmentation": [], + "text": "Innovation spaces in the closed/proprietary\nand open data ecosystem" + }, + { + "id": 126504, + "strid": "3fa94247-0d0c-4630-ad5b-8ada441f69cf", + "image_id": 205428, + "image_name": "15115.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 90.608, + 1695.823, + 1636.887, + 774.6049999999998 + ], + "priority": 5, + "parents": [ + 126500 + ], + "children": [], + "area": 153655.13038400002, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1 represents spaces where companies operate based on the\ninput/output relation to public data. As a reference, classic software\ncompanies are represented in the ‘closed input - closed output' space.\n\nCompanies that base their business models on open data have\ndifferent approaches to innovation. They can range from producers of\nproprietary software to those providing free-freemium platforms or\nthose operating in the completely open space (such as The Hyve).\nMany of the services provided by ELIXIR through their members\nenable innovators to create value from these freely available\nresources and ultimately contribute to a flourishing ecosystem in the\nclosed and open data space." + }, + { + "id": 126509, + "strid": "9d5d304a-6d2c-44f4-a805-a26e92e67338", + "image_id": 205428, + "image_name": "15115.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1905.023, + 1371.433, + 1307.8639999999998, + 1083.87 + ], + "priority": 6, + "parents": [ + 126500 + ], + "children": [ + 126507 + ], + "area": 2612611.4079589997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 126507, + "strid": "f245ce6a-196d-495b-a5f5-15864fcd120a", + "image_id": 205428, + "image_name": "15115.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1895.605, + 2489.248, + 794.065, + 36.09700000000021 + ], + "priority": 7, + "parents": [ + 126509 + ], + "children": [], + "area": 4718630.95504, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1: Innovation spaces in bio data ecosystems" + }, + { + "id": 126501, + "strid": "52765153-953c-43df-b37f-6168023e39ff", + "image_id": 205428, + "image_name": "15115.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 83.337, + 2588.762, + 1607.181, + 84.90000000000009 + ], + "priority": 8, + "parents": [ + 126511 + ], + "children": [ + 126505 + ], + "area": 215739.65879400002, + "iscrowd": 0, + "segmentation": [], + "text": "Example of a company using public data resources" + }, + { + "id": 126505, + "strid": "64e39070-be7a-474f-b45c-fef6e9076d0d", + "image_id": 205428, + "image_name": "15115.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 80.773, + 2692.95, + 2978.992, + 220.3829999999998 + ], + "priority": 9, + "parents": [ + 126501 + ], + "children": [], + "area": 217517.65034999998, + "iscrowd": 0, + "segmentation": [], + "text": "The Hyve is an IT company that provides professional services around open source software for biomedical informatics. They\npromote sharing of both code and data and the integration of data with publicly available open source solutions.\n\nELIXIR Core Data Resources used by the company: e Europe PMC e!" + }, + { + "id": 126502, + "strid": "076cfc2c-11cf-42b1-8c4e-d80121092ad1", + "image_id": 205428, + "image_name": "15115.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 82.315, + 2982.155, + 1269.277, + 175.44000000000005 + ], + "priority": 10, + "parents": [ + 126511 + ], + "children": [ + 126510, + 126506 + ], + "area": 245476.088825, + "iscrowd": 0, + "segmentation": [], + "text": "Revenue strategies along the value\nchain for data analysis" + }, + { + "id": 126506, + "strid": "d82de562-ed8c-45f8-8a93-9cee52dff424", + "image_id": 205428, + "image_name": "15115.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 80.901, + 3178.62, + 1273.569, + 949.0720000000001 + ], + "priority": 11, + "parents": [ + 126502 + ], + "children": [], + "area": 257153.53661999997, + "iscrowd": 0, + "segmentation": [], + "text": "There is a wide range of open life science data\ninfrastructures that can be used to build complex\ndata pipelines. Based on the inductive analysis of field\ndata - 26 interviews across thirteen complementors,\ninvestors and platform providers - we present six\nstrategies of complementors to appropriate value\nfrom open data infrastructures and gain revenue.\nFinancial value can be generated either through de-\ncontextualisation, re-contextualisation, and\ncontextualisation of open data. Figure 2 overviews\nthe different strategies with the core/main activities\ncomprised by each business model along the value\nchain coloured in dark blue and complimentary/side\nactivities coloured in light blue." + }, + { + "id": 126510, + "strid": "8221c44d-b151-4df8-8987-df6b34791da0", + "image_id": 205428, + "image_name": "15115.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1424.614, + 3028.733, + 1814.7000000000003, + 1009.8760000000002 + ], + "priority": 12, + "parents": [ + 126502 + ], + "children": [ + 126508 + ], + "area": 4314775.434062, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 126508, + "strid": "3a74f47a-3398-45c8-aa48-77601f8f8baf", + "image_id": 205428, + "image_name": "15115.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1412.519, + 4094.289, + 1016.6789999999999, + 37.297000000000025 + ], + "priority": 13, + "parents": [ + 126510 + ], + "children": [], + "area": 5783261.003991, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2: Appropriation of value in the open bio data ecosystems" + }, + { + "id": 157329, + "strid": "610150d8-dead-4a4b-8c89-aedb07e80163", + "image_id": 206644, + "image_name": "24092.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 118.59, + 503.23, + 254.78, + 154.21000000000004 + ], + "priority": -1, + "parents": [], + "children": [ + 157304, + 157306, + 157302, + 157301, + 157307, + 157312, + 157303, + 157305, + 157300 + ], + "area": 59678.0457, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 157300, + "strid": "ed686d72-f7e6-41d4-ad8b-920b34e7f971", + "image_id": 206644, + "image_name": "24092.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 710.641, + 212.761, + 2008.518, + 424.96500000000003 + ], + "priority": 1, + "parents": [ + 157329 + ], + "children": [], + "area": 151196.689801, + "iscrowd": 0, + "segmentation": [], + "text": "© Identification of a novel 39kDa~\npolypeptide asa serum biomarker for\narthralgia in Chikungunya" + }, + { + "id": 157301, + "strid": "e6c90c5d-c3da-4bcd-9b21-b23f021b3e30", + "image_id": 206644, + "image_name": "24092.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 57.094, + 821.252, + 3266.264, + 489.7840000000001 + ], + "priority": 2, + "parents": [ + 157329 + ], + "children": [], + "area": 46888.561688, + "iscrowd": 0, + "segmentation": [], + "text": "Goutam Patra'”, Sudip Kumar Dutta’, Arindam Naskar’, Manab Kumar Ghosh’, R.S. Bhattacharya’,\nYogiraj Ray’ , Soumen Halder’, Anusri Tripathi’, BhaswatiBandyopadhyay*, Sumi Mukhopadhyay!“and\nBibhuti Saha?\n\n'Department of Laboratory,Medicine, 7 Department of Biochemistry and Medical Biotechnology~>Department of Tropical\nMedicine, and +Department of Microbiology, Virology unit, Calcutta School of Tropical Medicine, Kolkata.\n*Corresponding author e mait: drsumimukhopadhyay @ gmaikcom" + }, + { + "id": 157302, + "strid": "cc119d93-66f7-474f-8b69-9840990c3d56", + "image_id": 206644, + "image_name": "24092.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 136.871, + 1409.972, + 315.135, + 43.531999999999925 + ], + "priority": 3, + "parents": [ + 157329 + ], + "children": [ + 157308 + ], + "area": 192984.277612, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 157308, + "strid": "051ad855-8b67-4173-b2bc-ac9ea0380ac1", + "image_id": 206644, + "image_name": "24092.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 128.532, + 1467.543, + 685.693, + 1397.3299999999997 + ], + "priority": 4, + "parents": [ + 157302 + ], + "children": [], + "area": 188626.236876, + "iscrowd": 0, + "segmentation": [], + "text": "Chikungunya (CHIKV) is a mosquito\nborne arboviral infection which has\nrecently _ re-emerged in several\nepidemics. Acute onset of fever and\npolyarthralgia are primary clinical\nfindings, with the management being\nprimarily supportive and symptomatic.\nThe persistence or _ relapse _ of\nrheumatologic symptoms in some\npatients can continue for months to\nyears following the acute illness.\nCurrently there is no __ specific,\ndiagnostic and prognostic biomarker\nfor CHIKV-induced _ polyarthralgia,\nwhich — significantly affects. patients\nquality of life but is being treated.\nSome diagnostic tools are available for\nearly diagnosis of Rheumatoid Arthritis\n(RA). Anti CCP appears to be a\npromising marker with good sensitivity\n(77-80%) but variable specificity (33-\n77%). Further, Inflammatory markers\nlike IL-6 and CICs have also been\nutilized. as signature molecules of RA.\nHowever, these have low sensitivity\nand specificity. Therefore, there is a\nneed to identify and characterize a\nnovel biomarker for early detection of\narthritis induced by CHIKV to better\nhelp inform treatment." + }, + { + "id": 157304, + "strid": "6a4387e2-634d-4b4e-8ee9-d9c810f1bf82", + "image_id": 206644, + "image_name": "24092.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 131.589, + 2951.941, + 100.82999999999998, + 41.95499999999993 + ], + "priority": 5, + "parents": [ + 157329 + ], + "children": [ + 157309 + ], + "area": 388442.96424899995, + "iscrowd": 0, + "segmentation": [], + "text": "AIm" + }, + { + "id": 157309, + "strid": "5e0d6732-0208-4859-ac5b-a5b061bb12db", + "image_id": 206644, + "image_name": "24092.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 128.816, + 3021.064, + 686.877, + 623.5230000000001 + ], + "priority": 6, + "parents": [ + 157304 + ], + "children": [], + "area": 389161.38022399996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 157305, + "strid": "bec40aac-8efc-403a-9b8d-281c9dcd3f48", + "image_id": 206644, + "image_name": "24092.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 126.38, + 3731.845, + 190.74199999999996, + 44.49299999999994 + ], + "priority": 7, + "parents": [ + 157329 + ], + "children": [ + 157310 + ], + "area": 471630.57109999994, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 157310, + "strid": "4f10a466-bb56-46e4-8d35-2cf8b677faac", + "image_id": 206644, + "image_name": "24092.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 122.588, + 3793.402, + 681.698, + 882.2079999999996 + ], + "priority": 8, + "parents": [ + 157305 + ], + "children": [], + "area": 465025.56437599997, + "iscrowd": 0, + "segmentation": [], + "text": "Clinically, 200 suspected Chikungunya\ncases were enrolled in Calcutta School\nof Tropical Medicine (2011-2014) and\ntested both by IgM ELISA and RT PCR\nof whom 44 patients were confirmed.\n\nControl population included patients\nwith Rheumatoid Arthritis (RA) (n=15),\nDengue (n=30) and Healthy Donors\n(HD) (n=44).\n\nAdditionally 15 Chikungunya cases\nwere longitudinally monitored for up to\n9 months.\n\nSerum from all the study subjects was\nsubsequently processed to _ study\ndifferent parameters like CIC, serum\ncytokines like IL6 and anti-CCP levels." + }, + { + "id": 157303, + "strid": "e3c35897-b894-481f-a02a-38bad73ca309", + "image_id": 206644, + "image_name": "24092.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 940.607, + 1401.418, + 193.36899999999991, + 43.88000000000011 + ], + "priority": 9, + "parents": [ + 157329 + ], + "children": [ + 157314, + 157317, + 157319, + 157326, + 157320, + 157321, + 157327, + 157315, + 157322 + ], + "area": 1318183.5807259998, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 157314, + "strid": "2a125fe3-c379-4cea-8d2f-fda26db6471b", + "image_id": 206644, + "image_name": "24092.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 933.696, + 1460.119, + 2340.606, + 91.68499999999995 + ], + "priority": 10, + "parents": [ + 157303 + ], + "children": [], + "area": 1363307.2698239998, + "iscrowd": 0, + "segmentation": [], + "text": "The symptoms of Chikungunya in our confirmed cases included rash, pain in the joints of lower limbs and back (with or without the\npresence of swelling), vomiting, nausea, headache, chills, fever and polyarthralgia (which may persist), as shown below:" + }, + { + "id": 157315, + "strid": "1d1ab739-0157-4a0c-8cc6-ce152974a5a6", + "image_id": 206644, + "image_name": "24092.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1090.137, + 1614.164, + 665.336, + 354.73900000000003 + ], + "priority": 11, + "parents": [ + 157303 + ], + "children": [ + 157316 + ], + "area": 1759659.900468, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 157316, + "strid": "4cad7c9c-77bc-417c-b7fc-07405f33ae7e", + "image_id": 206644, + "image_name": "24092.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1025.74, + 1979.288, + 1118.081, + 30.121000000000095 + ], + "priority": 12, + "parents": [ + 157315 + ], + "children": [], + "area": 2030234.8731200001, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1: Clinical signs and symptoms of patients with Chikungunya and Chikungunya Follow up ." + }, + { + "id": 157317, + "strid": "fe30c0a1-75da-4b13-9d42-1fba594f3d96", + "image_id": 206644, + "image_name": "24092.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2378.164, + 1621.396, + 588.3579999999997, + 331.53099999999995 + ], + "priority": 13, + "parents": [ + 157303 + ], + "children": [ + 157318 + ], + "area": 3855945.596944, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 157318, + "strid": "652a2418-bafd-4675-9692-dfa5c6cde968", + "image_id": 206644, + "image_name": "24092.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2366.031, + 1980.278, + 789.3429999999998, + 29.766000000000076 + ], + "priority": 14, + "parents": [ + 157317 + ], + "children": [], + "area": 4685399.1366179995, + "iscrowd": 0, + "segmentation": [], + "text": "Figure2:Photographs of symptomatic Chikungunya infected patients." + }, + { + "id": 157319, + "strid": "6b6adf44-a3a8-4e4c-87a9-2e2702efa435", + "image_id": 206644, + "image_name": "24092.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 931.96, + 2019.94, + 2343.11, + 372.42700000000013 + ], + "priority": 15, + "parents": [ + 157303 + ], + "children": [], + "area": 1882503.2824000001, + "iscrowd": 0, + "segmentation": [], + "text": "SDS PAGE analysis of CIC from Chikungunya patients revealed the presence of at least 10. major polypeptides of which 39kDa\npolypeptide is exclusively present in the CIC of Chikungunya patients.\n\nIL-6 and CICs of Chikungunya patients’ had good correlation (r?=0.600) among patients having persistent polyarthralgia. (Figure 3)\nThe expression of this newly identified marker was also monitored longitudinally and had good clinical correlation.\n\nAnalysis of anti-CCP titres revealed that among the confirmed Chikungunya patients, almost half (45.5%) were anti-CCP positive and\nwhen they were followed up, only one patient with persisting arthralgia was anti-CCP positive.\n\nInterestingly, during follow up, 39kDa protein was detected only in Chikungunya patients with persisting arthralgia (Figure 4 &\n\nFigure 5). /....... i ita. = Aen | | a\" — ——_————— Oi |" + }, + { + "id": 157320, + "strid": "8c9a3694-dfca-49e2-9505-aa9256b78126", + "image_id": 206644, + "image_name": "24092.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1107.732, + 2446.447, + 428.7829999999999, + 389.70899999999983 + ], + "priority": 16, + "parents": [ + 157303 + ], + "children": [ + 157324 + ], + "area": 2710007.628204, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 157324, + "strid": "1215db29-982f-4e01-add3-a9e501fae479", + "image_id": 206644, + "image_name": "24092.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 915.815, + 2868.027, + 823.992, + 31.327000000000226 + ], + "priority": 17, + "parents": [ + 157320 + ], + "children": [], + "area": 2626582.147005, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3: Correlation of IL-6 and CICs of Chikungunya infected patients" + }, + { + "id": 157321, + "strid": "86d1226c-e4e7-4bc8-859d-a332bd118347", + "image_id": 206644, + "image_name": "24092.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1751.911, + 2363.012, + 773.1109999999999, + 390.87800000000016 + ], + "priority": 18, + "parents": [ + 157303 + ], + "children": [ + 157323 + ], + "area": 4139786.7159320004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 157323, + "strid": "0b35b4d0-7c5e-482a-abf2-59d4e4d7a0ac", + "image_id": 206644, + "image_name": "24092.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1772.197, + 2777.35, + 741.1139999999998, + 129.17500000000018 + ], + "priority": 19, + "parents": [ + 157321 + ], + "children": [], + "area": 4922011.33795, + "iscrowd": 0, + "segmentation": [], + "text": "Fig » Silver stained SDS-PAGE gel (7.5%) of immune\n\ncomplexes isolated from the serum of patients. (Lane A: Standard\ntein marker; Lane B: Chikungunya ( 2 days); Lane C:\nikungunya (5 days) ; Lane D: Healthy donor" + }, + { + "id": 157322, + "strid": "c36dbd5b-0dfa-49d9-b1a3-ee6dd15ccfaa", + "image_id": 206644, + "image_name": "24092.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2555.374, + 2361.864, + 672.078, + 390.8409999999999 + ], + "priority": 20, + "parents": [ + 157303 + ], + "children": [ + 157325 + ], + "area": 6035445.857136, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 157325, + "strid": "8040e90f-cd4e-43e6-a16a-b9a1d27dc1a3", + "image_id": 206644, + "image_name": "24092.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2577.78, + 2761.386, + 613.2730000000001, + 162.26299999999992 + ], + "priority": 21, + "parents": [ + 157322 + ], + "children": [], + "area": 7118245.603080001, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 5: ver stained SDS-PAGE gel (7.5%) of\n\ni es isolated from the serum of follow\nwith arthralgia(Lane A: Chikungunya\n\naS J); Lane B: Chikungunya (270 days FU)\n\nLan Healthy donor" + }, + { + "id": 157326, + "strid": "d60e3c3f-e5ab-4617-8e1f-67be2ea77983", + "image_id": 206644, + "image_name": "24092.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 933.891, + 3000.113, + 2341.003, + 137.90599999999995 + ], + "priority": 22, + "parents": [ + 157303 + ], + "children": [], + "area": 2801778.529683, + "iscrowd": 0, + "segmentation": [], + "text": "Chikungunya patients demonstrated approximately a 30 fold increase in IL-6 as compared to HD revealing increased inflammatory\nresponse during the infection. This study demonstrated that the IL-6 titres were even higher in patients with Chikungunya than\n\nRheumatoid Arthritis (Figure 6). ——_" + }, + { + "id": 157327, + "strid": "80a72bc2-a711-4c8a-b77c-e20b5ea152d1", + "image_id": 206644, + "image_name": "24092.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1880.167, + 3140.771, + 640.252, + 481.453 + ], + "priority": 23, + "parents": [ + 157303 + ], + "children": [ + 157328 + ], + "area": 5905173.988757, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 157328, + "strid": "349fff1e-d778-4fb9-aadb-3aab93f26cd0", + "image_id": 206644, + "image_name": "24092.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1609.228, + 3700.147, + 1253.2439999999997, + 30.460000000000036 + ], + "priority": 24, + "parents": [ + 157327 + ], + "children": [], + "area": 5954380.156516, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 6: Serum IL-6 profile in Chikungunya, Chikungunya follow-up patients and the Control population." + }, + { + "id": 157306, + "strid": "2c20007d-220b-4b19-ba3c-9e8c658949d9", + "image_id": 206644, + "image_name": "24092.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 937.441, + 3869.757, + 296.5150000000001, + 44.35100000000011 + ], + "priority": 25, + "parents": [ + 157329 + ], + "children": [ + 157311 + ], + "area": 3627668.8718370004, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion" + }, + { + "id": 157311, + "strid": "80590a8e-51ed-4646-8688-e6a11904e64c", + "image_id": 206644, + "image_name": "24092.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 935.3, + 3933.342, + 1537.762, + 779.1399999999999 + ], + "priority": 26, + "parents": [ + 157306 + ], + "children": [], + "area": 3678854.7726, + "iscrowd": 0, + "segmentation": [], + "text": "A novel arthralgia severity marker (39kDa protein) in the serum Circulating Immune\nComplex of patients with Chikungunya infection with persistent polyarthralgia was\nidentified, which had good clinical correlation from baseline, all the way up to 9 months\nfollow up. Interestingly, the expression of this newly identified marker 39 kDa protein\nwas very high at onset , which gradually decreases with resolution of symptoms.\n\n39kDa protein was shown to be even more sensitive than the conventional. inflammatory\nmarker anti-CCP, according to this study, as the anti-CCP was only positive in 1 patient in\nfollow up.\n\nIL-6 and 39kDa protein in CICs had good correlation (r2=0.600) among patients with\npersistent polyarthralgia showing heightened inflammatory response.\n\nFurther characterisation of this novel molecule is on-going and will be beneficial to tailor\nihe symptomatic treatment of the patients diagnosed with Chikungunya induced\npolyarthralgia, especially when polyarthralgia persists, impacting patient life even once\nthe infection itself has resolved." + }, + { + "id": 157312, + "strid": "e60275ba-46bf-4cc0-a77e-0b46f0f9b324", + "image_id": 206644, + "image_name": "24092.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2592.868, + 3863.907, + 681.3389999999999, + 292.2389999999996 + ], + "priority": 27, + "parents": [ + 157329 + ], + "children": [], + "area": 10018600.815276, + "iscrowd": 0, + "segmentation": [], + "text": "Ethics approval was obtained from\nInstitutional Ethical committee _ of\nCalcutta School of Tropical Medicine.\n\nThe authors don't have a commercial\nor other association that might pose a\nconflict of interest." + }, + { + "id": 157307, + "strid": "28edafa2-f222-49f4-9c69-ef0664d8ce65", + "image_id": 206644, + "image_name": "24092.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2595.668, + 4207.005, + 516.6619999999998, + 55.516999999999825 + ], + "priority": 28, + "parents": [ + 157329 + ], + "children": [ + 157313 + ], + "area": 10919988.25434, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements" + }, + { + "id": 157313, + "strid": "a482fec6-f739-462c-9338-60a14880b884", + "image_id": 206644, + "image_name": "24092.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2595.145, + 4291.764, + 679.2049999999999, + 368.2960000000003 + ], + "priority": 29, + "parents": [ + 157307 + ], + "children": [], + "area": 11137749.885780001, + "iscrowd": 0, + "segmentation": [], + "text": "We are thankful to the Director,\nSchool of Tropical Medicine for\ngiving permission to do the study\nand NRHM, Ministry of Health and\nFamily Welfare, Government of West\nBengal, India for providing funding\nfor this work and finally all the\npatients, their family and staff." + }, + { + "id": 87870, + "strid": "7f49abab-b517-421e-8d73-9f853cd32558", + "image_id": 203912, + "image_name": "121146.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 36.98, + 61.92, + 60.65, + 53.06999999999999 + ], + "priority": -1, + "parents": [], + "children": [ + 87842, + 87835, + 87836, + 87840, + 87867, + 87841, + 87839, + 87838, + 87866, + 87837 + ], + "area": 2289.8016, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 87835, + "strid": "59106d03-ae48-41c8-8908-1ec595035517", + "image_id": 203912, + "image_name": "121146.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 76.511, + 14.262, + 681.182, + 31.281999999999996 + ], + "priority": 1, + "parents": [ + 87870 + ], + "children": [], + "area": 1091.199882, + "iscrowd": 0, + "segmentation": [], + "text": "CUM EM ERM NT BM Mo KaT" + }, + { + "id": 87836, + "strid": "9d13725a-9d81-42ca-ac48-7e71b2b1a682", + "image_id": 203912, + "image_name": "121146.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 158.735, + 62.447, + 570.726, + 67.144 + ], + "priority": 2, + "parents": [ + 87870 + ], + "children": [], + "area": 9912.524545000002, + "iscrowd": 0, + "segmentation": [], + "text": "Gwénaille André-Leroux!)Stéphanie Petrella*> and Claudine Mayer”?\n\nINRA-Unité MIG (Mathématique Inforatique et Genome), Jouy-en-Josas\n\n2 Unité de Microbiologie Structurale Département de Biologie Structural etchimie; Baris\n3Cellule Pasteur, université Paris Diderot, Paris" + }, + { + "id": 87837, + "strid": "e33a391c-718d-4c0c-8a56-e4457aca731f", + "image_id": 203912, + "image_name": "121146.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 19.869, + 141.799, + 711.119, + 61.803 + ], + "priority": 3, + "parents": [ + 87870 + ], + "children": [], + "area": 2817.404331, + "iscrowd": 0, + "segmentation": [], + "text": "Among all known bacterial targets, M. tuberculosis DNA gyrase is a validated target for.anti-tubercular drug discovery [1]. It has\nbeen, shawn that inhibitors of this enzyme are‘also active against non-replicating mycabacteria, which might be important forthe\neradication of persistent organisms. A novel inhibitor of M. tuberculosis DNA gyrase would be effective against multi-drug resistant (MOR)\nTR and it could also be effective against fluatoquinolone-resistant M. tuberculosis." + }, + { + "id": 87838, + "strid": "086cd583-c48f-4f65-87c1-a75abf812663", + "image_id": 203912, + "image_name": "121146.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 251.505, + 224.064, + 278.177, + 19.593999999999994 + ], + "priority": 4, + "parents": [ + 87870 + ], + "children": [ + 87852, + 87853 + ], + "area": 56353.21632, + "iscrowd": 0, + "segmentation": [], + "text": "Bacterial type II topoisomerases" + }, + { + "id": 87853, + "strid": "efbafb7a-4069-46bd-b368-61084e08454c", + "image_id": 203912, + "image_name": "121146.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 43.057, + 232.261, + 585.654, + 90.32500000000002 + ], + "priority": 5, + "parents": [ + 87838 + ], + "children": [], + "area": 10000.461877, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 87852, + "strid": "b7703a49-8450-4d8f-80cd-c988c1ada97d", + "image_id": 203912, + "image_name": "121146.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 639.151, + 238.537, + 168.29200000000003, + 81.33200000000002 + ], + "priority": 6, + "parents": [ + 87838 + ], + "children": [], + "area": 152461.162087, + "iscrowd": 0, + "segmentation": [], + "text": "DNA gyrase is a bacterial type I\ntoposcmerase. 5 unique in catahying\nthe negate superclng of DNA and is 3\nhetertetrameie enzyme 2). Fach\nsubunit consists of two. sry\ndomains (APase, TOPRIM, biabane\nreunion domain (BRD) and cing!" + }, + { + "id": 87839, + "strid": "0382a570-c5e6-4cdb-9058-cf064aa78497", + "image_id": 203912, + "image_name": "121146.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 119.059, + 343.322, + 313.953, + 20.391999999999996 + ], + "priority": 7, + "parents": [ + 87870 + ], + "children": [ + 87857, + 87854, + 87855, + 87856 + ], + "area": 40875.573998, + "iscrowd": 0, + "segmentation": [], + "text": "Crystal structure of the BRD domain" + }, + { + "id": 87854, + "strid": "cc4c1e4d-d195-4cae-8205-f4fe167bdf58", + "image_id": 203912, + "image_name": "121146.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 23.704, + 383.93, + 372.642, + 121.15899999999999 + ], + "priority": 8, + "parents": [ + 87839 + ], + "children": [], + "area": 9100.676720000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 87857, + "strid": "ed462f4d-2f13-46a8-b167-df6aa2a5ae54", + "image_id": 203912, + "image_name": "121146.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 28.486, + 505.991, + 371.045, + 37.037000000000035 + ], + "priority": 9, + "parents": [ + 87839 + ], + "children": [], + "area": 14413.659626, + "iscrowd": 0, + "segmentation": [], + "text": "We have determined the(crystal structures of the four M. tuberculosis ONA gyrase\ndomains [3,45]. In the\\crystal structure of the BRD domain, the N-terminal hel\noccupies the DNA cledbage site of a symmetry-related molecule (3)." + }, + { + "id": 87855, + "strid": "ed8ca407-01a0-4a0c-9a4b-21e3efe27705", + "image_id": 203912, + "image_name": "121146.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 422.028, + 374.775, + 96.84900000000005, + 38.048 + ], + "priority": 10, + "parents": [ + 87839 + ], + "children": [], + "area": 158165.5437, + "iscrowd": 0, + "segmentation": [], + "text": "Lpsnshelpe-ghiiatlbenhiachien\neae Lee\n“and the active site" + }, + { + "id": 87856, + "strid": "124563d6-32a3-4142-a1ff-c214a2559791", + "image_id": 203912, + "image_name": "121146.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 408.927, + 426.811, + 117.05799999999999, + 106.73700000000002 + ], + "priority": 11, + "parents": [ + 87839 + ], + "children": [], + "area": 174534.541797, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 87840, + "strid": "77dd40fe-a299-43c4-9b04-6c9f2f211ef0", + "image_id": 203912, + "image_name": "121146.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 576.488, + 340.197, + 211.91700000000003, + 18.963000000000022 + ], + "priority": 12, + "parents": [ + 87870 + ], + "children": [ + 87849, + 87851, + 87850 + ], + "area": 196119.48813600003, + "iscrowd": 0, + "segmentation": [], + "text": "Helix — BRD interactions" + }, + { + "id": 87851, + "strid": "a8ecf03c-898b-45f4-ac5b-d85a046914e0", + "image_id": 203912, + "image_name": "121146.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 557.071, + 371.027, + 124.92100000000005, + 126.00400000000002 + ], + "priority": 13, + "parents": [ + 87840 + ], + "children": [], + "area": 206688.381917, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 87849, + "strid": "8c0a44cd-d8a4-420d-939b-f1798f1c0bb4", + "image_id": 203912, + "image_name": "121146.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 685.014, + 372.063, + 129.346, + 125.132 + ], + "priority": 14, + "parents": [ + 87840 + ], + "children": [], + "area": 254868.363882, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 87850, + "strid": "258dfccd-3e47-4310-9910-18548c6f0faa", + "image_id": 203912, + "image_name": "121146.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 562.8, + 504.651, + 243.45600000000002, + 25.609999999999957 + ], + "priority": 15, + "parents": [ + 87840 + ], + "children": [], + "area": 284017.5828, + "iscrowd": 0, + "segmentation": [], + "text": "Ghis interaction provides useful starting points for a\npéptidomimetics approach." + }, + { + "id": 87841, + "strid": "42a98f5f-5443-486d-9b44-a8f1b1efd610", + "image_id": 203912, + "image_name": "121146.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 76.436, + 557.138, + 267.48, + 20.413999999999987 + ], + "priority": 16, + "parents": [ + 87870 + ], + "children": [ + 87858, + 87859, + 87860, + 87843 + ], + "area": 42585.40016800001, + "iscrowd": 0, + "segmentation": [], + "text": "Wi rcleelmemalibauieciey" + }, + { + "id": 87843, + "strid": "c1a6750e-433d-44d0-a869-6f85b156cf14", + "image_id": 203912, + "image_name": "121146.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 23.384, + 587.62, + 383.445, + 108.029 + ], + "priority": 17, + "parents": [ + 87841 + ], + "children": [], + "area": 13740.90608, + "iscrowd": 0, + "segmentation": [], + "text": "Wiki-u6q tomplex as well as variants were optinlged’ with 4 5,000 iterations\nprotéeol using CHARMM force field, constraint on the backbone of gyrase and helix\natthe smart minimizer algorithm implemented in DiscoveryStudio®. After\nrnimization, the interaction energy between'the optimized ligand and the protein\nwas evaluated using the calculated “Interaction Energy implemented in\nDiscoverystudio®. The variants were'ranked and compared to wild-type system\nwith @ scoring function implemented from total potential energy, interaction\nenergy 2s well as number of salt badges and H-bonds interactions." + }, + { + "id": 87858, + "strid": "d7cfb127-a6e8-4cbf-a362-e3b4accaf97c", + "image_id": 203912, + "image_name": "121146.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 25.0, + 708.024, + 236.97699999999998, + 189.058 + ], + "priority": 18, + "parents": [ + 87841 + ], + "children": [], + "area": 17700.6, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 87860, + "strid": "dd63cfed-a55e-4d1e-8174-10d5c2252c6d", + "image_id": 203912, + "image_name": "121146.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 279.332, + 745.461, + 127.98500000000001, + 58.428 + ], + "priority": 19, + "parents": [ + 87841 + ], + "children": [], + "area": 208231.112052, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 87859, + "strid": 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Data on total number of.\nclaims, number of claims with final\nVerdict of accusation , financial cost\nand top 5 medical specialties-with the\nhighest rate of medical errors were\nextracted and analyzed.\n\nResults: the total nuthber of claims\ncontinued to escalaté throughout the\nreport period. Obstetrics/Gynecology\nremained the specialty with the highest\nincidenprate of claims. The highest\nnumbér of claims was observed in\nprivate medical practice. 38 cases of.\ndeath as a result of medical errors were\nprovided a compensation of 10,000\nand 500,000 SR and 44 disability cases\nwere provided a compensation of\n1000-50,000 SR\n\nConclusion: The iritidence medical\nerrors claims coittinues to increase\nPreventive measures to reduce the\nincidence fate through continuous\neducation courses and monitoring of\nadhefence to practice code are\nessential" + }, + { + "id": 73639, + "strid": "90ac9d9e-317e-42bf-8a33-dbd1eb832fcf", + "image_id": 203368, + "image_name": "120107.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 294.55, + 146.84, + 339.17299999999994, + 180.26500000000001 + ], + "priority": 4, + "parents": [ + 73643 + ], + "children": [], + "area": 43251.722, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 73637, + "strid": "970f1323-0b5b-42e0-9fbf-3d619e1c1558", + "image_id": 203368, + "image_name": "120107.png", + "category_id": 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Coia & Michael A. Crognale\n\nUniversity of Nevada Reno, Cognitive & Brain Science" + }, + { + "id": 100519, + "strid": "f7cb001d-ea5c-4388-a35d-14e0bb84d225", + "image_id": 204388, + "image_name": "122033.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 196.57, + 705.931, + 611.5530000000001, + 86.94100000000003 + ], + "priority": 3, + "parents": [ + 100535 + ], + "children": [ + 100528 + ], + "area": 138764.85667, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 100528, + "strid": "e44e0cf7-4062-40b1-99d9-a266af07943d", + "image_id": 204388, + "image_name": "122033.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 200.923, + 878.949, + 816.434, + 419.15099999999995 + ], + "priority": 4, + "parents": [ + 100519 + ], + "children": [], + "area": 176601.069927, + "iscrowd": 0, + "segmentation": [], + "text": "It is not known if illusory (induced) colors\nactivate cortical pathways in the same\nmanner as physical colors. We used hdEEG to\nmeasure cortical response to two different\ntypes of color experience: illusory colors\ncreated by the juxtaposition of two thin lines\n(the watercolor illusion), and physical colors\nfilling control patterns with no illusion." + }, + { + "id": 100522, + "strid": "5119d100-195a-48e3-b485-7fd4590d3a19", + "image_id": 204388, + "image_name": "122033.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 350.197, + 1420.903, + 447.8059999999999, + 95.95900000000006 + ], + "priority": 5, + "parents": [ + 100535 + ], + "children": [ + 100527, + 100532 + ], + "area": 497595.96789100004, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 100527, + "strid": "dd732210-fec3-477a-81cc-ed8360a95215", + "image_id": 204388, + "image_name": "122033.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 193.961, + 1564.839, + 787.736, + 98.99000000000001 + ], + "priority": 6, + "parents": [ + 100522 + ], + "children": [], + "area": 303517.737279, + "iscrowd": 0, + "segmentation": [], + "text": "Are there differences in neural activity\ngenerated by these distinct types of color?" + }, + { + "id": 100532, + "strid": "d454a6d4-e48f-4f34-afbb-c25ee9ebfebd", + "image_id": 204388, + "image_name": "122033.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 395.254, + 1810.949, + 405.1840000000001, + 1512.6820000000002 + ], + "priority": 7, + "parents": [ + 100522 + ], + "children": [], + "area": 715784.836046, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 100520, + "strid": "33c759e9-9bf1-4307-9012-c9f7f6f935ff", + "image_id": 204388, + "image_name": "122033.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1913.272, + 707.795, + 665.1639999999998, + 106.15099999999995 + ], + "priority": 8, + "parents": [ + 100535 + ], + "children": [ + 100529 + ], + "area": 1354204.35524, + "iscrowd": 0, + "segmentation": [], + "text": "Methodology" + }, + { + "id": 100529, + "strid": "ca935eeb-c214-48aa-be68-4804875b7a3a", + "image_id": 204388, + "image_name": "122033.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1272.33, + 880.162, + 2093.865, + 176.44900000000007 + ], + "priority": 9, + "parents": [ + 100520 + ], + "children": [], + "area": 1119856.51746, + "iscrowd": 0, + "segmentation": [], + "text": "A 256 electrode HDEEG system was used (EGI). Two different types of presentation modes were used:\nSteady State: exchange each image with control stimuli (4 Hz exchange rate)\nOnset: exchange each image with blank screen (250 ms on, 750 ms off)" + }, + { + "id": 100524, + "strid": "466c4a3d-4799-454c-a741-b8eba16ea0ca", + "image_id": 204388, + "image_name": "122033.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2206.731, + 1118.945, + 358.0369999999998, + 99.14900000000011 + ], + "priority": 10, + "parents": [ + 100535 + ], + "children": [ + 100525, + 100533, + 100526, + 100534 + ], + "area": 2469210.618795, + "iscrowd": 0, + "segmentation": [], + "text": "CSOT LS" + }, + { + "id": 100525, + "strid": "4ed1d60d-2613-4f43-b912-1d0f0d44bbae", + "image_id": 204388, + "image_name": "122033.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1528.668, + 1261.012, + 619.1290000000001, + 111.26700000000005 + ], + "priority": 11, + "parents": [ + 100524 + ], + "children": [], + "area": 1927668.6920159997, + "iscrowd": 0, + "segmentation": [], + "text": "Steady State" + }, + { + "id": 100533, + "strid": "9587f84c-3870-452b-9744-beb8f2092d64", + "image_id": 204388, + "image_name": "122033.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1104.981, + 1468.469, + 1054.8100000000002, + 1951.882 + ], + "priority": 12, + "parents": [ + 100524 + ], + "children": [], + "area": 1622630.344089, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 100526, + "strid": "32bf155c-d749-420e-a4b8-dcc0ae51bd16", + "image_id": 204388, + "image_name": "122033.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2730.866, + 1267.371, + 296.0630000000001, + 84.96900000000005 + ], + "priority": 13, + "parents": [ + 100524 + ], + "children": [], + "area": 3461020.3732860005, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 100534, + "strid": "d24f00b2-38b6-4cee-9a09-72738429bec8", + "image_id": 204388, + "image_name": "122033.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2222.45, + 1411.575, + 1243.558, + 2058.9080000000004 + ], + "priority": 14, + "parents": [ + 100524 + ], + "children": [], + "area": 3137154.8587499997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 100521, + "strid": "4d6da82f-3af3-4922-b571-cabc1a02b3ed", + "image_id": 204388, + "image_name": "122033.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3626.226, + 714.274, + 588.5040000000004, + 89.37599999999998 + ], + "priority": 15, + "parents": [ + 100535 + ], + "children": [ + 100530 + ], + "area": 2590118.949924, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 100530, + "strid": "ad34bb0a-a2ab-478a-8eea-35c472d19b3c", + "image_id": 204388, + "image_name": "122033.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3587.45, + 953.876, + 929.9530000000004, + 1528.586 + ], + "priority": 16, + "parents": [ + 100521 + ], + "children": [], + "area": 3421982.4562, + "iscrowd": 0, + "segmentation": [], + "text": "Both illusory and real surface colors\ngenerate differential responses when\ncompared to a control stimulus of\njust lines without color on inside, as\nrevealed by steady state EEG.\n\nOnset VEP recorded around Oz had a\nmain component near 150 ms after\nstimulus onset. There were no major\ndifferences in waveforms between\nconditions for Oz electrodes\n\nThe larger magnitude activity\ngenerated by the real color may be\ndue to higher perceived saturation\nlevel\n\nFuture studies will incorporate color\nmatches, source localization and\ntemporal analysis." + }, + { + "id": 100523, + "strid": "908af5f8-9b7a-44a7-aaf9-5c70bb1d28c2", + "image_id": 204388, + "image_name": "122033.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3562.559, + 2562.069, + 983.9960000000001, + 111.04700000000003 + ], + "priority": 17, + "parents": [ + 100535 + ], + "children": [ + 100531 + ], + "area": 9127521.974571, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements" + }, + { + "id": 100531, + "strid": "5fdbe6c8-d247-4c50-aee5-1c10c26e92fe", + "image_id": 204388, + "image_name": "122033.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3653.576, + 2804.632, + 848.1599999999999, + 316.70899999999983 + ], + "priority": 18, + "parents": [ + 100523 + ], + "children": [], + "area": 10246936.164032001, + "iscrowd": 0, + "segmentation": [], + "text": "Data analysis was performed with Brainstorm (Tadel et al.\n2011), which is documented and freely available for download\nonline under the GNU general public license\n(http://neuroimage.usc.edu/brainstorm).\n\n \n\nResearch reported in this poster was supported by National\nInstitute of General Medical Sciences of the National Institutes\nof Health under grant number P20GM103650" + }, + { + "id": 165117, + "strid": "3667e6f0-a601-462a-ad0e-d335e6ec5a48", + "image_id": 206940, + "image_name": "6689.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 455.85, + 23.39, + 248.07999999999993, + 60.34 + ], + "priority": -1, + "parents": [], + "children": [ + 165099, + 165103, + 165101, + 165102, + 165096, + 165097, + 165098, + 165100 + ], + "area": 10662.3315, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 165096, + "strid": "f5ed6441-c0a8-4c9e-bd81-204dce870e01", + "image_id": 206940, + "image_name": "6689.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 537.567, + 122.556, + 2675.562, + 73.55400000000002 + ], + "priority": 1, + "parents": [ + 165117 + ], + "children": [], + "area": 65882.061252, + "iscrowd": 0, + "segmentation": [], + "text": "Predicting Fractal Model Parameters in Accordance with Perceptual Descriptions" + }, + { + "id": 165097, + "strid": "e5b91e19-fe98-4546-8b10-80073f89000f", + "image_id": 206940, + "image_name": "6689.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 764.058, + 275.794, + 2225.934, + 203.897 + ], + "priority": 2, + "parents": [ + 165117 + ], + "children": [], + "area": 210722.61205199998, + "iscrowd": 0, + "segmentation": [], + "text": "Junyu Dong*', Lina Wang’, Jun Liu’, Yanhai Gan’, Xin Sun!\n‘Department of Computer Science and Technology, Ocean University of China, China\n* dongjunyu@ouc. edu.cn" + }, + { + "id": 165098, + "strid": "01596cff-2016-4990-bbd0-802469c52f9b", + "image_id": 206940, + "image_name": "6689.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 24.053, + 590.54, + 448.066, + 57.815000000000055 + ], + "priority": 3, + "parents": [ + 165117 + ], + "children": [ + 165104 + ], + "area": 14204.25862, + "iscrowd": 0, + "segmentation": [], + "text": "¢ Introduction" + }, + { + "id": 165104, + "strid": "f253be94-256c-4c14-b6e0-db240b834319", + "image_id": 206940, + "image_name": "6689.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 38.106, + 708.929, + 1534.581, + 391.04599999999994 + ], + "priority": 4, + "parents": [ + 165098 + ], + "children": [], + "area": 27014.448474, + "iscrowd": 0, + "segmentation": [], + "text": "The 1/f8 fractal model can be used to generate textures resembling\nnatural surfaces by varying its parameters (high cut-off frequency\nand B)[1]. However, it is difficult to choose proper parameter values\nso that the model can produce textures described using perceptual\nfeatures[2], e.g. roughness and directionality. This work focuses on\nautomatically finding such parameter values." + }, + { + "id": 165099, + "strid": "2b6191ac-3965-4873-a661-5a0e2675a8f5", + "image_id": 206940, + "image_name": "6689.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 24.281, + 1161.109, + 319.934, + 55.51800000000003 + ], + "priority": 5, + "parents": [ + 165117 + ], + "children": [ + 165116, + 165106, + 165107 + ], + "area": 28192.887628999997, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 165106, + "strid": "19c58071-9757-46ac-a994-488d51d0bfbd", + "image_id": 206940, + "image_name": "6689.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 40.385, + 1293.499, + 1540.055, + 535.722 + ], + "priority": 6, + "parents": [ + 165099 + ], + "children": [], + "area": 52237.957115, + "iscrowd": 0, + "segmentation": [], + "text": "Texture samples\n\n16000 textures were generated using fractal model by sampling in\nthe parameter space at a linear scale. The resolution of each texture\nwas set at 256*256. Each height map of textured surface was\nrendered by a physics-based rendering engine — LuxRender. The\ntwelve perceptual features for each texture were first predicted by\nusing the PCANet classification model[3], which were initially trained\nbased on texture samples with subjective ratings[4]." + }, + { + "id": 165116, + "strid": "1c079092-929b-455a-9f9b-24a473872329", + "image_id": 206940, + "image_name": "6689.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 93.745, + 1881.954, + 1418.29, + 858.113 + ], + "priority": 7, + "parents": [ + 165099 + ], + "children": [ + 165112 + ], + "area": 176423.77773, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 165112, + "strid": "019ab028-2574-4859-9bc5-d512988bca88", + "image_id": 206940, + "image_name": "6689.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 84.019, + 2807.05, + 1426.249, + 152.8989999999999 + ], + "priority": 8, + "parents": [ + 165116 + ], + "children": [], + "area": 235845.53395000004, + "iscrowd": 0, + "segmentation": [], + "text": "Fig.1 Fractal texture samples generated with different parameter values.\nThe symbol 'f' means the high cut-off frequency parameter and the\nsymbol 'b' represents the beta parameter of the fractal model." + }, + { + "id": 165107, + "strid": "3cc0e359-d6cb-4db8-a695-dfbf2f24d507", + "image_id": 206940, + "image_name": "6689.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 42.353, + 3012.702, + 1536.881, + 671.1990000000001 + ], + "priority": 9, + "parents": [ + 165099 + ], + "children": [], + "area": 127596.96780600002, + "iscrowd": 0, + "segmentation": [], + "text": "Mapping Model\n\nThe sparse autoencoder[5] was then used to construct the mapping\nbetween the twelve scales (perceptual feature values) and the two\nparameters. It consisted of one input layer with 12 neurons, one\nhidden layer with 200 neurons and one output layer with 2\nneurons[6]. The autoencoder was learned by optimizing a cost\nfunction defined as the mean square error between the predicted\nand real parameters. The optimized sparse autoencoder was able to\npredict parameter values for the model to generate textures in\naccordance with perceptual description[7]." + }, + { + "id": 165101, + "strid": "39bae6a7-1af1-4f7e-b16a-b18dd075ba30", + "image_id": 206940, + "image_name": "6689.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1708.298, + 589.509, + 282.90800000000013, + 53.370000000000005 + ], + "priority": 10, + "parents": [ + 165117 + ], + "children": [ + 165105, + 165115, + 165114 + ], + "area": 1007057.045682, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 165105, + "strid": "63c78adb-2ce6-4295-8e59-ee0c4d829d46", + "image_id": 206940, + "image_name": "6689.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1705.522, + 704.695, + 1539.067, + 236.288 + ], + "priority": 11, + "parents": [ + 165101 + ], + "children": [], + "area": 1201872.8257900001, + "iscrowd": 0, + "segmentation": [], + "text": "We randomly chose 14000 textures for training and the remaining\n2000 for testing. The best result of the experiment was 0.031,\nobtained by the optimised combination of 3 parameters:\nsparsity(0.05), lamda(1e-11), beta(0.01)." + }, + { + "id": 165115, + "strid": "83f3efd3-5279-4721-a411-df7fdfa73fd2", + "image_id": 206940, + "image_name": "6689.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2043.216, + 967.715, + 838.4630000000002, + 812.6050000000001 + ], + "priority": 12, + "parents": [ + 165101 + ], + "children": [ + 165110 + ], + "area": 1977250.77144, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 165110, + "strid": "cb83c199-4a85-4161-a6dc-550943b2b722", + "image_id": 206940, + "image_name": "6689.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1772.434, + 1809.452, + 1451.771, + 369.7769999999998 + ], + "priority": 13, + "parents": [ + 165115 + ], + "children": [], + "area": 3207134.246168, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 2. The network of the sparse autoencoder. The three layers were\ncomposed of 12, 200, and 2 neurons, respectively. The neurons of first\nlayer correspond to the twelve perceptual feature values, /.e. in order,\ncontrast, repetition, granularity,randomness, roughness, feature density,\ndirectionality, structural complexity, coarseness, regularity, locally\norientation and uniformity. Those neurons of the last layer correspond to\nthe two parameters." + }, + { + "id": 165114, + "strid": "2fa719e8-ae7c-48ad-a7d1-bf48e09c7be9", + "image_id": 206940, + "image_name": "6689.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1769.59, + 2425.546, + 1420.76, + 491.1790000000001 + ], + "priority": 14, + "parents": [ + 165101 + ], + "children": [ + 165111 + ], + "area": 4292221.94614, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 165111, + "strid": "1a3e085f-59fc-479e-98c7-00d9b52137ba", + "image_id": 206940, + "image_name": "6689.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1763.801, + 2229.588, + 1437.382, + 156.83199999999988 + ], + "priority": 15, + "parents": [ + 165114 + ], + "children": [], + "area": 3932549.543988, + "iscrowd": 0, + "segmentation": [], + "text": "Table1. The test errors of the sparse autoencoder with three parameters,\ni.e. sparsity, lamda and beta. The bold values below are the parameter\nvalues corresponding to the best result." + }, + { + "id": 165102, + "strid": "ec490301-f15c-4091-b9dd-935f134fa376", + "image_id": 206940, + "image_name": "6689.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1700.968, + 2980.021, + 394.8320000000001, + 53.623999999999796 + ], + "priority": 16, + "parents": [ + 165117 + ], + "children": [ + 165108 + ], + "area": 5068920.360328001, + "iscrowd": 0, + "segmentation": [], + "text": "@¢ Conclusion" + }, + { + "id": 165108, + "strid": "f46671fb-6a24-40c8-9e4d-f76962d74e2a", + "image_id": 206940, + "image_name": "6689.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1682.309, + 3094.472, + 1584.327, + 175.14499999999998 + ], + "priority": 17, + "parents": [ + 165102 + ], + "children": [], + "area": 5205858.095848001, + "iscrowd": 0, + "segmentation": [], + "text": "Our method can accurately predict the parameter values of the fractal\nmodel, and with these values the model can produce texture in\naccordance with perceptual description." + }, + { + "id": 165103, + "strid": "60336898-08f6-4651-afb0-4ce3bc3aea83", + "image_id": 206940, + "image_name": "6689.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1695.09, + 3327.469, + 666.0649999999998, + 68.79300000000012 + ], + "priority": 18, + "parents": [ + 165117 + ], + "children": [ + 165109 + ], + "area": 5640359.427209999, + "iscrowd": 0, + "segmentation": [], + "text": "¢ Acknowledgements" + }, + { + "id": 165109, + "strid": "caf0fe4d-28b8-45ec-8c99-5b0544c471dd", + "image_id": 206940, + "image_name": "6689.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1674.832, + 3442.548, + 1585.405, + 295.2249999999999 + ], + "priority": 19, + "parents": [ + 165103 + ], + "children": [], + "area": 5765689.551936, + "iscrowd": 0, + "segmentation": [], + "text": "This work was supported by grants from National Natural Science\nFoundation of China (Project No.61271405 , 61401413) and the\nPh.D. Program Foundation of Ministry of Education of China\n(20120132110018) and Qingdao Science and Technology Plan\nProjects (12-1-4-1-(8)-jch)." + }, + { + "id": 165100, + "strid": "6118a607-0065-42fa-b222-4fef13e98bb3", + "image_id": 206940, + "image_name": "6689.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 23.931, + 3801.431, + 410.53, + 55.3159999999998 + ], + "priority": 20, + "parents": [ + 165117 + ], + "children": [ + 165113 + ], + "area": 90972.045261, + "iscrowd": 0, + "segmentation": [], + "text": "¢ References" + }, + { + "id": 165113, + "strid": "86b00c0b-26d9-4c1f-80bf-247f6896175c", + "image_id": 206940, + "image_name": "6689.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 48.754, + 3914.148, + 3204.232, + 638.424 + ], + "priority": 21, + "parents": [ + 165100 + ], + "children": [], + "area": 190830.371592, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 51106, + "strid": "bf02119a-c9c6-48b5-b0f7-97e6ed27ea9c", + "image_id": 202510, + "image_name": "118794.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 117.61, + 157.31, + 231.05, + 385.07 + ], + "priority": -1, + "parents": [], + "children": [ + 51085, + 51086, + 51090, + 51084, + 51087, + 51105, + 51088, + 51089 + ], + "area": 18501.2291, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 51084, + "strid": "0d6bfe41-2669-4d01-a4a0-572feb5afb39", + "image_id": 202510, + "image_name": "118794.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 317.706, + 171.084, + 5070.19, + 255.45499999999998 + ], + "priority": 1, + "parents": [ + 51106 + ], + "children": [], + "area": 54354.413304, + "iscrowd": 0, + "segmentation": [], + "text": "Implementing clinical practice guidelines and assessing pain-related patient reported outcomes.\nPreliminary data from PAIN OUT, an international acute pain registry games" + }, + { + "id": 51085, + "strid": "6c4d9857-b3af-45b0-8907-d1b681e4e6fa", + "image_id": 202510, + "image_name": "118794.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1071.937, + 599.93, + 3565.7340000000004, + 171.27099999999996 + ], + "priority": 2, + "parents": [ + 51106 + ], + "children": [], + "area": 643087.1644099999, + "iscrowd": 0, + "segmentation": [], + "text": "Ruth Zaslansky,! C.R.Chapman,? Winfried Meissner,t PAIN OUT Collaboration\n\n‘Dept. of Anesthesia & Intensive Care, Jena University Hospital, Germany; 2Anesthesiology, Uni of Utah, Salt Lake City, UT, USA" + }, + { + "id": 51086, + "strid": "e7aa2184-22a8-4088-ab7a-d6fac6db79f5", + "image_id": 202510, + "image_name": "118794.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 536.034, + 948.991, + 849.3539999999999, + 86.8789999999999 + ], + "priority": 3, + "parents": [ + 51106 + ], + "children": [ + 51091 + ], + "area": 508691.441694, + "iscrowd": 0, + "segmentation": [], + "text": "Background & Aims" + }, + { + "id": 51091, + "strid": "28c0b049-2261-4307-92dc-ede59ab83bb9", + "image_id": 202510, + "image_name": "118794.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 133.982, + 1169.476, + 1593.29, + 668.5329999999999 + ], + "priority": 4, + "parents": [ + 51086 + ], + "children": [], + "area": 156688.733432, + "iscrowd": 0, + "segmentation": [], + "text": "PAIN OUT is an international, observational acute pain\nregistry, assessing post-surgical outcomes related to pain. It\naims to assist clinicians improve management of their\npatient's pain after surgery.\n\nWe assessed whether practices recommended by major\nnational & international guidelines for all patients undergoing\nsurgery '% were implemented. We also assessed pain-\nrelated patient-reported outcomes (PROs) in a large\npopulation of patients after surgery." + }, + { + "id": 51087, + "strid": "2c0d6350-7f8f-40c2-87ca-5d026ca0d86d", + "image_id": 202510, + "image_name": "118794.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 785.452, + 2047.478, + 359.03600000000006, + 69.04599999999982 + ], + "priority": 5, + "parents": [ + 51106 + ], + "children": [ + 51093, + 51092 + ], + "area": 1608195.6900560001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 51092, + "strid": "691b5ece-7d30-469d-be4d-1bc18cbe9b96", + "image_id": 202510, + "image_name": "118794.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 88.142, + 2262.987, + 1698.87, + 668.1059999999998 + ], + "priority": 6, + "parents": [ + 51087 + ], + "children": [], + "area": 199464.200154, + "iscrowd": 0, + "segmentation": [], + "text": "Collaborators from 11 clinical sites in 8 European countries and\nIsrael participating in PAIN OUT (www.pain-out.eu) contributed\ndata for this study. All obtained approval to collect non-identified\npatient data from their local ethics committee.\n\nAdult patients on the first day after a variety of orthopaedic and\ngeneral surgery procedures filled in the validated International\nPain Outcomes (IPO) questionnaire.* Patients filled in the\nquestionnaire in their native language (see Fig. 1). Demographic\n& clinical were abstracted from the patient's file." + }, + { + "id": 51093, + "strid": "204a8850-f607-44d3-b416-9d28b758b60e", + "image_id": 202510, + "image_name": "118794.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 116.035, + 3141.044, + 1635.543, + 643.777 + ], + "priority": 7, + "parents": [ + 51087 + ], + "children": [ + 51094 + ], + "area": 364471.04053999996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 51094, + "strid": "ef946181-f579-4cc9-bfae-9df0ce19357c", + "image_id": 202510, + "image_name": "118794.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 140.764, + 3888.001, + 1179.976, + 48.8090000000002 + ], + "priority": 8, + "parents": [ + 51093 + ], + "children": [], + "area": 547290.572764, + "iscrowd": 0, + "segmentation": [], + "text": "Fig 1. The International Pain Outcomes questionnaire" + }, + { + "id": 51088, + "strid": "68746430-7bff-47e6-a9e6-f5a358150fb3", + "image_id": 202510, + "image_name": "118794.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2630.091, + 975.123, + 314.06899999999996, + 70.59500000000003 + ], + "priority": 9, + "parents": [ + 51106 + ], + "children": [ + 51097, + 51095, + 51096, + 51100 + ], + "area": 2564662.226193, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 51095, + "strid": "20f7b97d-2873-4419-99e3-b1ba08af2cb3", + "image_id": 202510, + "image_name": "118794.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1917.545, + 1169.055, + 1747.1480000000001, + 1134.186 + ], + "priority": 10, + "parents": [ + 51088 + ], + "children": [], + "area": 2241715.5699750003, + "iscrowd": 0, + "segmentation": [], + "text": "From Feb — Dec 2011, 6447 adult patient filled in the IPO\nquestionnaire.\n\nPractices: (1) 65% of patients reported they received information\nabout pain treatment options (range by institution 27 — 85%) (2)\nPain was assessed in 76% of patients (range by institution 0.3\n\nto 99.8%). (3) 71% of patients reporting worst pain 26 were\ntreated by an opioid (range by institution 44 — 93%).\n\nPROs: 48% of patients reported worst pain of 2 6 (range 25-70%).\nSee Fig. 2 for distribution between sites.\n\n23% of patients reported experiencing severe pain 10-50%% of\nthe time on POD1 (range 2 — 37% by institution). See Fig. 3.\n\nThere were no Clinically relevant differences in PROs (pain\nintensity, side effects or satisfaction) between patients who had\ntheir pain assessed vs. not." + }, + { + "id": 51096, + "strid": "46e840ae-bf6a-46bb-849e-6f63a4aa0d42", + "image_id": 202510, + "image_name": "118794.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1911.593, + 2465.499, + 877.6569999999999, + 1026.5569999999998 + ], + "priority": 11, + "parents": [ + 51088 + ], + "children": [ + 51098 + ], + "area": 4713030.629907, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 51098, + "strid": "e0f9fffb-71e5-4504-8466-81b4a161de09", + "image_id": 202510, + "image_name": "118794.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2062.808, + 3562.426, + 678.788, + 50.61499999999978 + ], + "priority": 12, + "parents": [ + 51096 + ], + "children": [], + "area": 7348600.852208, + "iscrowd": 0, + "segmentation": [], + "text": "Fig 2. Worst pain across sites." + }, + { + "id": 51097, + "strid": "ae003a5a-b746-4385-b298-f501a7de8d5e", + "image_id": 202510, + "image_name": "118794.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2848.196, + 2465.751, + 902.3739999999998, + 1080.775 + ], + "priority": 13, + "parents": [ + 51088 + ], + "children": [ + 51099 + ], + "area": 7022942.135196, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 51099, + "strid": "4a3ded3c-4eca-4325-b2a5-e75cf933f459", + "image_id": 202510, + "image_name": "118794.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 3041.487, + 3561.002, + 580.7870000000003, + 50.565000000000055 + ], + "priority": 14, + "parents": [ + 51097 + ], + "children": [], + "area": 10830741.289974, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 3 Time in severe pain." + }, + { + "id": 51100, + "strid": "0369a2c4-43c4-4024-9bb3-686d2728b17b", + "image_id": 202510, + "image_name": "118794.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2064.825, + 3688.581, + 1658.4099999999999, + 167.29399999999987 + ], + "priority": 15, + "parents": [ + 51088 + ], + "children": [], + "area": 7616274.263324999, + "iscrowd": 0, + "segmentation": [], + "text": "Eacn column represents Ssummarizea data trom one medical center. Solid\nlines on the bar represent the mean for that site. Patients assessed ‘Worst\npain’ on a 0-10 NRS scale and ‘Time in severe pain’ as a percentage scale." + }, + { + "id": 51089, + "strid": "ac75f7eb-defb-424b-a937-8b2062868850", + "image_id": 202510, + "image_name": "118794.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4086.349, + 975.056, + 1128.7820000000002, + 70.5 + ], + "priority": 16, + "parents": [ + 51106 + ], + "children": [ + 51102, + 51101, + 51103 + ], + "area": 3984419.1105440003, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion & Conclusions" + }, + { + "id": 51101, + "strid": "4eaa5645-488f-4d64-951e-3cf399667663", + "image_id": 202510, + "image_name": "118794.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3862.075, + 1169.458, + 1580.3730000000005, + 960.288 + ], + "priority": 17, + "parents": [ + 51089 + ], + "children": [], + "area": 4516534.50535, + "iscrowd": 0, + "segmentation": [], + "text": "PAIN OUT aims to assist clinicians improve how they\nmanage their patient’s pain by providing them with tools to\ncarry out standardized audit and receive web-based\nfeedback and benchmarking. Audit & feedback are tools for\nimproving quality of care in many fields of medicine. The\nregisiry-based data provides clinicians and researchers with\ninformation about ‘real-world’ care.\n\nOur data, from 11 medical center, along with studies from\nEurope © and the USA ® indicate that practices\nrecommended by guidelines are increasingly being\nimplemented. However, this is not matched by similar\nimprovements in PROs. Further work needs to be carried\nout to assess how to close this discrepancy." + }, + { + "id": 51102, + "strid": "5c14bd2a-b4f9-4a5e-9738-fe77a8f8f645", + "image_id": 202510, + "image_name": "118794.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3846.749, + 2265.869, + 1634.1080000000002, + 215.067 + ], + "priority": 18, + "parents": [ + 51089 + ], + "children": [], + "area": 8716229.309881, + "iscrowd": 0, + "segmentation": [], + "text": "PAIN OUT is a not-for profit, academic initiative. It is endorsed\nby IASP. Participation is open to every hospital, worldwide.\nJoin the PAIN OUT network! -> www.pain-out.eu" + }, + { + "id": 51103, + "strid": "f07b2c3a-886b-4485-9605-4dedfa40821a", + "image_id": 202510, + "image_name": "118794.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3919.365, + 2640.705, + 1551.938, + 603.194 + ], + "priority": 19, + "parents": [ + 51089 + ], + "children": [], + "area": 10349886.752324998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 51105, + "strid": "94b146d7-d358-4514-a7e5-bee618b29144", + "image_id": 202510, + "image_name": "118794.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3940.024, + 3870.198, + 1417.4379999999996, + 191.10800000000017 + ], + "priority": 20, + "parents": [ + 51106 + ], + "children": [], + "area": 15248673.004751999, + "iscrowd": 0, + "segmentation": [], + "text": "Funding: European Community s Seventh Framework\nProgram FP7/2007-2013 under Grant agreement No.\n223590." + }, + { + "id": 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"eea723d7-e3e6-49a4-a4dc-1d11a50991d4", + "image_id": 207351, + "image_name": "7435.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1944.457, + 811.816, + 744.6569999999999, + 256.49299999999994 + ], + "priority": 7, + "parents": [ + 175419 + ], + "children": [], + "area": 1578541.303912, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 175420, + "strid": "8ca63627-22e5-40d4-a5b2-944391688030", + "image_id": 207351, + "image_name": "7435.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 664.551, + 2324.747, + 716.764, + 47.91199999999981 + ], + "priority": 8, + "parents": [ + 175438 + ], + "children": [ + 175428 + ], + "area": 1544912.943597, + "iscrowd": 0, + "segmentation": [], + "text": "1. Human Capacity and Information" + }, + { + "id": 175428, + "strid": "512fe487-116c-47d5-80bd-d3c11a4314ea", + "image_id": 207351, + "image_name": "7435.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 658.883, + 2428.445, + 796.9089999999999, + 551.127 + ], + "priority": 9, + "parents": [ + 175420 + ], + "children": [], + "area": 1600061.1269350003, + "iscrowd": 0, + "segmentation": [], + "text": "The human brain, despite its complexity and the\nsheer number of neurons of which it is made, has\nlimitations in its capaeity to absorb information.\nLimits on information uptake can be assessed by a\nvariety of assays, such as the attentional blink\nassay. In this test candidates are presented with an\nincreasingly rapid stream of images until they no\nlonger distinguish distinct images, typically at time\nintervals of 105 to 120 msec, the atten blink.\nIn the modern environment effects of information\nload are compounded by its multiple modes Oa\nCte" + }, + { + "id": 175421, + "strid": "88bf175d-d8ad-4009-9470-aee2f00cfc83", + "image_id": 207351, + "image_name": "7435.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1775.168, + 1220.096, + 994.287, + 49.656999999999925 + ], + "priority": 10, + "parents": [ + 175438 + ], + "children": [ + 175427 + ], + "area": 2165875.3761279997, + "iscrowd": 0, + "segmentation": [], + "text": "2. Distraction, Information Capacity, and Anxiety" + }, + { + "id": 175427, + "strid": "06d674ac-59cd-49cd-b1ee-1163c2a81b82", + "image_id": 207351, + "image_name": "7435.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1776.535, + 1321.256, + 1167.503, + 425.66100000000006 + ], + "priority": 11, + "parents": [ + 175421 + ], + "children": [], + "area": 2347257.52796, + "iscrowd": 0, + "segmentation": [], + "text": "Limits on information capacity are related to psychological stress, seen\nin increased anxiety and distraction. Proliferation of information modes\nand the sheer magnitude of information input require improved attentional\nfocus, increased decisional loads, and more rapid resolutions. In high\nstress environments, particularly, such as corporate competition or military\nactivities, affect status is exacerbated by load conditions that lead\nincreasingly to negative outcomes. In such circumstances threat appraisal\nis heightened affecting interoceptive awareness and amygdala regulation\n\n(van Wingen, 2011)." + }, + { + "id": 175424, + "strid": "432c5b29-4082-40f2-ab88-e4549d8934a8", + "image_id": 207351, + "image_name": "7435.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1780.18, + 2543.191, + 961.1049999999998, + 49.498999999999796 + ], + "priority": 12, + "parents": [ + 175438 + ], + "children": [ + 175433, + 175434 + ], + "area": 4527337.75438, + "iscrowd": 0, + "segmentation": [], + "text": "3. Neurotechnology and Information Processing" + }, + { + "id": 175434, + "strid": "c3bd30ce-60be-4926-a8e0-4c9a11ca8de5", + "image_id": 207351, + "image_name": "7435.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1777.056, + 2647.001, + 1168.554, + 600.8310000000001 + ], + "priority": 13, + "parents": [ + 175424 + ], + "children": [], + "area": 4703869.009056, + "iscrowd": 0, + "segmentation": [], + "text": "Proposals to handle information streams look to neurotechnologies to\nprocess information load to manageable levels. In such cases the preferred\nmodel is Fodor’s computational theory of mind that links information to _\nan internal processing mechanism sharing computer like analogies. . ,\nProsthetic implants and insertable chips access streams of data via brain-\ncomputer interfacing. Yet the use of neurotechnologies eal its own\nset of challenges. More rapid downloading through the exclusion of\nsensory filtration amplifies rather than scrutinizes input. sntcoeeTarTE\nneurotechnologies, moreover, can bypass contextualization mechanisms\nLEAL WO eCCouplerKeueet-laCoemleM ole bietatryKeermee\nchland and Stee 2013). Th trate NOC\n\ntus, are neglected in such views and de led from ee\nmaintain each othet\n\nisms, cognitive and corporal, that shape a" + }, + { + "id": 175433, + "strid": "a2833b11-fba9-4eb5-b3e8-c021bff08940", + "image_id": 207351, + "image_name": "7435.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2972.361, + 2398.659, + 562.6610000000001, + 251.31500000000005 + ], + "priority": 14, + "parents": [ + 175424 + ], + "children": [], + "area": 7129680.463899, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 175422, + "strid": "b622585e-70c4-47e1-812b-bf81a31fcb11", + "image_id": 207351, + "image_name": "7435.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3470.743, + 868.2, + 679.5139999999997, + 48.99300000000005 + ], + "priority": 15, + "parents": [ + 175438 + ], + "children": [ + 175435 + ], + "area": 3013299.0726, + "iscrowd": 0, + "segmentation": [], + "text": "4. Information and Brain Training" + }, + { + "id": 175435, + "strid": "3ed3dd7b-1f2b-4bef-9d9a-62bfc438528f", + "image_id": 207351, + "image_name": "7435.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3470.406, + 968.684, + 1108.1099999999997, + 369.0049999999999 + ], + "priority": 16, + "parents": [ + 175422 + ], + "children": [], + "area": 3361726.765704, + "iscrowd": 0, + "segmentation": [], + "text": "ASC (ere ir: ee more 1 ice, 1\n\nhi sized brain-featurés that-conce\n| e software, through net\n\ning regimes thatiseek to\nx the brain’s natural ability to,shape its functional needs.\n4\n\n \n \n\n \n\nAicnel et nry:\n\nNe ticity is now widely.studiéd, and practiced, to enable swifter\nand ocused learning. Yet; the magnitude of ififormation input\nsse alternatives are only temporary solutions to an" + }, + { + "id": 175423, + "strid": "25030342-9e46-4c4f-ba84-7a2c1b8ab77e", + "image_id": 207351, + "image_name": "7435.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3845.193, + 1577.247, + 573.3180000000002, + 39.36200000000008 + ], + "priority": 17, + "parents": [ + 175438 + ], + "children": [ + 175436 + ], + "area": 6064819.123671001, + "iscrowd": 0, + "segmentation": [], + "text": "5. The Consciousness Model" + }, + { + "id": 175436, + "strid": "604c55b2-3307-41ad-8f55-f10eba7e5757", + "image_id": 207351, + "image_name": "7435.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3841.601, + 1680.415, + 844.2220000000002, + 693.116 + ], + "priority": 18, + "parents": [ + 175423 + ], + "children": [], + "area": 6455483.944415, + "iscrowd": 0, + "segmentation": [], + "text": "We propose that a more salient context within\nwhich to consider information proeessing, ‘humanly-\nspeaking’, may lie in models based on embodied\ncognition. Normally, largerdata streams regularly\nproceed through our senses to our brains. According\nto DeHaene (2014) most such information is not\naccessible to our conscious selves, but appears to be\nROLLA MT alk uN Monae l xo velN veo iormes Neto\nCLS eSU LMT UZOCOeMTeCMI oem itLeComene ttle) CmKOmolibe\nconsciousness for decision making. In like manner\nexternal algorithmic processing that then\ncontextualizes load limits to ‘human brain’ constraints\nmay afford a more humane approach to managing\ninformation loads. Which option should be\nprioritized?" + }, + { + "id": 175425, + "strid": "db8abeed-061e-4fca-9fc0-0620e505dc61", + "image_id": 207351, + "image_name": "7435.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3609.883, + 2730.531, + 244.11400000000003, + 37.409999999999854 + ], + "priority": 19, + "parents": [ + 175438 + ], + "children": [ + 175437 + ], + "area": 9856897.437872998, + "iscrowd": 0, + "segmentation": [], + "text": "(Conclusions" + }, + { + "id": 175437, + "strid": "c9227253-5f09-4fe3-9221-36031c80a47d", + "image_id": 207351, + "image_name": "7435.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3605.817, + 2830.552, + 1081.8460000000005, + 412.34299999999985 + ], + "priority": 20, + "parents": [ + 175425 + ], + "children": [], + "area": 10206452.520984, + "iscrowd": 0, + "segmentation": [], + "text": "The human factor in information management is increasingly the\n: s+\n\nFoL-se- TUK MLN oe Mop Rela) . Es\n\n \n\nExcessive and inappropriate use of neurotechnologies can exacerbate\npe a ai impactandignoreshumarrcapatities...\n> p\n\nDevelopmental and use priorities should Sniieerennt uman\n\na: au through empha$iS on models ‘mimicing brain -\n° —\n\nope" + }, + { + "id": 175430, + "strid": "8bd8e95d-9469-42d8-afef-ab37d07b478f", + "image_id": 207351, + "image_name": "7435.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 68.795, + 3057.285, + 173.128, + 29.56399999999985 + ], + "priority": 21, + "parents": [ + 175438 + ], + "children": [ + 175429 + ], + "area": 210325.921575, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 175429, + "strid": "3cf19009-9283-4cfb-9ca2-a25b2ee0e833", + "image_id": 207351, + "image_name": "7435.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 68.943, + 3132.39, + 721.031, + 203.13499999999976 + ], + "priority": 22, + "parents": [ + 175430 + ], + "children": [], + "area": 215956.36377, + "iscrowd": 0, + "segmentation": [], + "text": "Churchland P and Churchland P (2013) What are beliefs? In The\nNeural Basis of Human Belief Systems. New York: Psychology\naK\n\nDehaene, S (2014). Consciousness and the Brain: Deciphering\nHow the Brain Codes Our Thoughts. New York: Penguin Group\n\nMoriya, J and Sugiura, Y (2013)" + }, + { + "id": 132972, + "strid": "8430a881-0e8e-4e6b-98bb-76913cb2a2d6", + "image_id": 205662, + "image_name": "15542.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 34.09, + 22.57, + 197.95, + 242.65000000000003 + ], + "priority": -1, + "parents": [], + "children": [ + 132954, + 132960, + 132958, + 132959, + 132955, + 132956, + 132957 + ], + "area": 769.4113000000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 132954, + "strid": "29a8eacb-a2d4-4586-b7dd-dac2ef894ce4", + "image_id": 205662, + "image_name": "15542.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 263.223, + 67.814, + 2806.623, + 231.95199999999997 + ], + "priority": 1, + "parents": [ + 132972 + ], + "children": [], + "area": 17850.204522, + "iscrowd": 0, + "segmentation": [], + "text": "The evolutionary signal in metagenome phyletic profiles predicts\nmany gene functions" + }, + { + "id": 132955, + "strid": "6f54c09f-da65-4fd6-8359-fa574cee306a", + "image_id": 205662, + "image_name": "15542.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 709.762, + 350.375, + 2001.613, + 371.70900000000006 + ], + "priority": 2, + "parents": [ + 132972 + ], + "children": [], + "area": 248682.86075, + "iscrowd": 0, + "segmentation": [], + "text": "Vedrana Vidulin?23, Tomislav Smuc2, SaSo Dzeroski?, Fran Supek’\n‘Department of Knowledge Technologies, Jozef Stefan Institute, Jamova cesta 39, 1000 Ljubljana, Slovenia\nDivision of Electronics, Ruder Boskovic¢ Institute, Bijenicka cesta 54, 10000 Zagreb, Croatia\n3 Faculty of Information Studies, Ljubljanska cesta 31A, 8000 Novo mesto, Slovenia\n4 Institute for Research in Biomedicine, C/ Baldiri Reixac 10, 08028 Barcelona, Spain\n\nContact: vedrana.vidulin @ijs.si" + }, + { + "id": 132956, + "strid": "0c38417b-c2e2-4b45-9782-d10b47616aab", + "image_id": 205662, + "image_name": "15542.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 466.859, + 762.122, + 350.72600000000006, + 57.01999999999998 + ], + "priority": 3, + "parents": [ + 132972 + ], + "children": [ + 132961 + ], + "area": 355803.514798, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 132961, + "strid": "29534671-df26-4fc5-8a1a-b6b99eb2aea5", + "image_id": 205662, + "image_name": "15542.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 190.685, + 885.084, + 912.8810000000001, + 589.304 + ], + "priority": 4, + "parents": [ + 132956 + ], + "children": [], + "area": 168772.24253999998, + "iscrowd": 0, + "segmentation": [], + "text": "The number of sequenced microbial genomes and\nmetagenomes continuously grows and with them the\nnumber of genes with unknown biological function.\nMany automated gene function prediction (GFP)\nmethods have been proposed, which can _ infer\nfunctions from various features derived from whole-\ngenome sequences. Fully sequenced genomes,\nhowever, do not cover many genes that can be found\nin uncultured microbial life. We propose a machine\nlearning approach that uses features derived from\nmetagenome data in order to improve GFP coverage\nand accuracy." + }, + { + "id": 132958, + "strid": "b2cea593-f8bc-461f-8492-3e97f9610ef6", + "image_id": 205662, + "image_name": "15542.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 551.876, + 1568.642, + 251.26800000000003, + 49.787000000000035 + ], + "priority": 5, + "parents": [ + 132972 + ], + "children": [ + 132968 + ], + "area": 865695.872392, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 132968, + "strid": "144260e5-e9c4-4e30-b789-9f45e5320e48", + "image_id": 205662, + "image_name": "15542.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 70.985, + 1654.918, + 1154.515, + 1152.675 + ], + "priority": 6, + "parents": [ + 132958 + ], + "children": [ + 132964 + ], + "area": 117474.35423, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 132964, + "strid": "f365ca44-b605-4ee1-9b84-1b9368f82de6", + "image_id": 205662, + "image_name": "15542.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 71.199, + 2849.791, + 1197.276, + 436.21399999999994 + ], + "priority": 7, + "parents": [ + 132968 + ], + "children": [], + "area": 202902.269409, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. Metagenome phyletic profiles and Phyletic profiles\nmethods. Previous research by us and others has shown that PP is\namong the top-performing methods based on genome-derived\nfeatures. In PP, feature values indicate the presence or absence of a\ngene family member (instance) across microbial genomes (features).\nMotivated by the predictive accuracy of PP, we propose MPP, where\nValues are relative abundances of COG-member genes _ in\nmetagenomes. We use the CLUS-HMC Random Forests algorithm to\nconstruct classification models." + }, + { + "id": 132957, + "strid": "66e2998f-bda0-4efa-b41f-6b3951f0bcd5", + "image_id": 205662, + "image_name": "15542.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2126.889, + 771.805, + 205.48700000000008, + 55.94399999999996 + ], + "priority": 8, + "parents": [ + 132972 + ], + "children": [ + 132971, + 132970, + 132969 + ], + "area": 1641543.564645, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 132969, + "strid": "5e286fbd-5e6b-43d8-926e-d7f9aa4d210c", + "image_id": 205662, + "image_name": "15542.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1418.808, + 949.08, + 344.41499999999996, + 840.2479999999999 + ], + "priority": 9, + "parents": [ + 132957 + ], + "children": [ + 132965 + ], + "area": 1346562.29664, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 132965, + "strid": "b0fd0b91-a25b-4179-9a4a-a7d5cce4f740", + "image_id": 205662, + "image_name": "15542.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1356.465, + 1855.495, + 499.69000000000005, + 1341.5749999999998 + ], + "priority": 10, + "parents": [ + 132969 + ], + "children": [], + "area": 2516914.0251749996, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2. MPP constructed\nfrom the metagenomic data\ncan help predict hundreds\nof gene functions that\nwould not be_ predicted\nusing only PP constructed\nfrom the whole-genome\nsequences. We compare\nMPP against PP in terms of\nthe number of ‘learnable’\ngene functions (GO terms)\ncovered by at least one\nprediction at precision (Pr)\nthresholds of >50%, 70% and\n90% (Pr is equivalent to 1 -\nfalse discovery rate). We find\nthat MPP is the only method\nthat can provide prediction\nfor 15-29% of the learnable\nfunctions (819, 714 and 664\nGO terms were learnable by\nboth MPP and PP, at the 50,\n70 and 90% thresholds,\nrespectively). This is a similar\nproportion to that of the\nfunctions learnable by PP\nbut not MPP (29-32%)." + }, + { + "id": 132970, + "strid": "3a47becc-400d-4faf-b7cd-7a67cebcf659", + "image_id": 205662, + "image_name": "15542.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1922.863, + 864.37, + 1352.1470000000002, + 1731.411 + ], + "priority": 11, + "parents": [ + 132957 + ], + "children": [ + 132966 + ], + "area": 1662065.09131, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 132966, + "strid": "a86610b1-6ade-414b-b8f3-011b8fa0b143", + "image_id": 205662, + "image_name": "15542.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1937.588, + 2626.702, + 1271.854, + 638.6639999999998 + ], + "priority": 12, + "parents": [ + 132970 + ], + "children": [], + "area": 5089466.2747760005, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3. Sampling metagenomes from diverse environments increases\nthe number of functions successfully predicted by MPP. We divide the\nMPP data set into seven parts, according to the environments from which\nmetagenomes were sampled. Interestingly, at Pr=50%, 21%, out of 725 GO\nterms learnable by using all 7 MPPs, are learnable by using only one MPP\nrepresenting single environment (of 7). Moreover, 49% are learnable from\nless than half of the environments (max. 3 of 7). At the more stringent\nthreshold of Pr=90%, this proportion of GO terms learnable from a single\nindividual environment are even higher, amounting to 30% (out of 601\nfunctions). For example, the GO term ‘Alcohol metabolism’ is learnable\nfrom human-associated metagenomes considerably better than from the\nrest of the environments (cross-validation area under precision recall curve\n(AUPRC)=0.09, next best is “engineered environment” at 0.03)." + }, + { + "id": 132971, + "strid": "9db06920-68a2-4b4f-91b6-4a83d22fbc0d", + "image_id": 205662, + "image_name": "15542.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1786.372, + 3348.739, + 1203.651, + 741.6079999999997 + ], + "priority": 13, + "parents": [ + 132957 + ], + "children": [ + 132967 + ], + "area": 5982093.584908, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 132967, + "strid": "8719ad72-6191-43dc-9821-fcf4ce49fea2", + "image_id": 205662, + "image_name": "15542.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1552.056, + 4108.748, + 1682.25, + 290.65300000000025 + ], + "priority": 14, + "parents": [ + 132971 + ], + "children": [], + "area": 6377006.985888, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 4. Diversity improves MPP predictive accuracy. In a simulation we gradually add\nmetagenomes to the MPP in order to keep the highest and the lowest possible diversity of sampled\nenvironments. With the high-diversity sampling approach, the maximal accuracy is reached with\n500 metagenomes, since representatives from the majority of environments are included. With the\nminimum-diversity approach, the same accuracy is achieved only with the complete set of 5049\nmetagenomes. 4" + }, + { + "id": 132959, + "strid": "01fa5f5d-c2a7-4194-badc-7eb8fb23b09b", + "image_id": 205662, + "image_name": "15542.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 573.139, + 3383.805, + 332.14099999999996, + 52.23199999999997 + ], + "priority": 15, + "parents": [ + 132972 + ], + "children": [ + 132962 + ], + "area": 1939390.613895, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 132962, + "strid": "be1a5ea1-b4d5-47c3-8b1a-1dc0f4cbd0fd", + "image_id": 205662, + "image_name": "15542.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 172.778, + 3491.563, + 1186.555, + 384.8159999999998 + ], + "priority": 16, + "parents": [ + 132959 + ], + "children": [], + "area": 603265.272014, + "iscrowd": 0, + "segmentation": [], + "text": "We introduce metagenome phyletic profiles (MPP), a novel\ngenome context method. In combination with machine\nlearning, MPP can predict many gene functions that would not\nbe predicted using only the standard PP constructed from the\nwhole-genome sequences. The predictive accuracy of MPPs\nincreases with the diversity of the environments from which\nmetagenomes are sampled." + }, + { + "id": 132960, + "strid": "0bc87ff3-0ab9-42c8-a6d2-eb91c41b9146", + "image_id": 205662, + "image_name": "15542.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 589.21, + 3957.017, + 521.6489999999999, + 63.615999999999985 + ], + "priority": 17, + "parents": [ + 132972 + ], + "children": [ + 132963 + ], + "area": 2331513.98657, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgement" + }, + { + "id": 132963, + "strid": "0b001c33-b49b-4f6d-8378-c3c7c8c8c629", + "image_id": 205662, + "image_name": "15542.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 284.811, + 4058.626, + 1162.039, + 344.3739999999998 + ], + "priority": 18, + "parents": [ + 132960 + ], + "children": [], + "area": 1155941.329686, + "iscrowd": 0, + "segmentation": [], + "text": "This project was supported by: the Republic of Slovenia and the European Union under\nthe European Regional Development Fund (grant “Raziskovalci-2.0-FIS-529008”,\nimplementation of the operation no. C3330-17-529008), the Croatian Science\nFoundation and the Centre of Excellence project “BioProspecting of Adriatic Sea”, the\nCroatian Government and the European Union through the European Regional\nDevelopment Fund (KK.01.1.1.01.0002), the European Commission via the grants ICT-\n2013-612944 MAESTRA and the ERC Starting Grant 757700 HYPER-INSIGHT, Slovenian\nResearch Agency (research core funding No. P2-0103 and projects No. N2-0056, L2-\n7509) and the European Commission (grants HBP SGA2, and LANDMARK)." + }, + { + "id": 196682, + "strid": "c63145cf-c020-4bb7-bd53-88df79f7689e", + "image_id": 208204, + "image_name": "9647.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 3380.48, + 49.28, + 161.92000000000007, + 147.84 + ], + "priority": -1, + "parents": [], + "children": [ + 196676, + 196673, + 196668, + 196671, + 196669, + 196672, + 196678, + 196670, + 196674 + ], + "area": 166590.0544, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 196668, + "strid": "59465ffe-19f5-4a16-af7f-dea4eed2112c", + "image_id": 208204, + "image_name": "9647.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 758.759, + 16.009, + 2145.533, + 209.03999999999996 + ], + "priority": 1, + "parents": [ + 196682 + ], + "children": [], + "area": 12146.972831000001, + "iscrowd": 0, + "segmentation": [], + "text": "MetaR: simple, high-level languages\nfor data analysis with the R ecosystem" + }, + { + "id": 196669, + "strid": "50c238f4-63a8-4ee1-b6cc-144a6b7568a0", + "image_id": 208204, + "image_name": "9647.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 770.244, + 231.94, + 2150.127, + 176.88 + ], + "priority": 2, + "parents": [ + 196682 + ], + "children": [], + "area": 178650.39336000002, + "iscrowd": 0, + "segmentation": [], + "text": "Fabien Campagne'”’ Alexander Pann‘, William ER Digan’, Manuele Simi'? ‘The HRH Prince Alwaleed Bin\nTalal Bin Abdulaziz Alsaud Institute for Computational Biomedicine. 7Department of Physiology and\nBiophysics, Weill Cornell Medicine, New York, NY, USA. *Correspondence to: fac2003@campagnelab.org." + }, + { + "id": 196674, + "strid": "d92013d8-2d84-4c4c-ab5f-dce479d3aa71", + "image_id": 208204, + "image_name": "9647.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 94.605, + 684.355, + 1571.575, + 472.50199999999995 + ], + "priority": 3, + "parents": [ + 196682 + ], + "children": [], + "area": 64743.404775, + "iscrowd": 0, + "segmentation": [], + "text": "Data analysis tools have become essential to the study of biology. Yet lan-\nguages such as R are not easily accessible to biologists with no program-\nming experience.\n\nWe applied language workbench technology (LWT) to create data analysis\nlanguages tailored for biologists with a range of experience: from beginners\nwith no programming experience, to expert bioinformaticians and statisti-\ncians." + }, + { + "id": 196672, + "strid": "87498bdc-fa36-4a95-88f8-9021c7d909ac", + "image_id": 208204, + "image_name": "9647.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 248.205, + 1351.265, + 1175.96, + 101.22399999999993 + ], + "priority": 4, + "parents": [ + 196682 + ], + "children": [ + 196679 + ], + "area": 335390.729325, + "iscrowd": 0, + "segmentation": [], + "text": "Simple language for beginners" + }, + { + "id": 196679, + "strid": "3ba20abd-ec22-4fd5-a33f-916cc9276dad", + "image_id": 208204, + "image_name": "9647.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 81.82, + 1458.963, + 1565.095, + 2162.349 + 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"iscrowd": 0, + "segmentation": [], + "text": "Joram Soch'3:*, Lorenz Deserno?4, Bjérn Schott?!* 49381 #4081\n\n1. Leibniz Institute for Neurobiology, Magdeburg, Germany 2. Charité Universitatsmedizin, Berlin, Germany 3. Otto von Guericke io\nUniversity, Magdeburg, Germany 4. Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany @: JoramSoch@web.de" + }, + { + "id": 33515, + "strid": "d9d8ffaa-2023-4339-a7f5-b9bc55f9793c", + "image_id": 201815, + "image_name": "117727.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 38.878, + 618.386, + 96.359, + 588.2950000000001 + ], + "priority": 3, + "parents": [ + 33540 + ], + "children": [ + 33517 + ], + "area": 24041.610908, + "iscrowd": 0, + "segmentation": [], + "text": "UO!NONPOJ}U|" + }, + { + "id": 33517, + "strid": "98890cb5-7036-49ff-9f67-50c813cd0fc8", + "image_id": 201815, + "image_name": "117727.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 158.059, + 534.707, + 3121.514, + 753.119 + ], + "priority": 4, + "parents": [ + 33515 + ], + "children": [], + "area": 84515.253713, + "iscrowd": 0, + "segmentation": [], + "text": "Self-Reference is a cognitive process in which information is related to oneself, whereas Reference to Others\nrefers to mental operations that make up judgments about others; self-reference and reference to others can be\nsummarized under the term social processing. Previous stugies indicate that both types of social processing\nactivate structures of the deiault mode network (DMN) [1, 2], in particular medial prefronial cortex (mPFC),\nposterior cingulate cortex (#*CC) and temporo-parietal junciion (TPJ). Furthermore, converging evidence shows\nthat anterior cingulate cortex (ACC) differentiates seli-referential stimuli from those related to others [8].\nAdditionally, meta-analysis suggests that posterior cingulate cortex (PCC) processes information about others\nrather than those about oneself [4]. However, liti!e is known about the intrinsic causal organization of the sociai\ncognition network so far. Measures of effective connectivity might help to elucidate the detailed neural\nprocessing of self-reference and reference to others." + }, + { + "id": 33516, + "strid": "dc978842-2609-444c-b4b1-e1851549739e", + "image_id": 201815, + "image_name": "117727.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 36.342, + 1571.83, + 98.89399999999999, + 423.471 + ], + "priority": 5, + "parents": [ + 33540 + ], + "children": [ + 33518, + 33519 + ], + "area": 57123.44585999999, + "iscrowd": 0, + "segmentation": [], + "text": "SPOUlo/\\" + }, + { + "id": 33518, + "strid": "557e91f9-59c1-4f2d-95f6-2950ef9a9921", + "image_id": 201815, + "image_name": "117727.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 152.987, + 1320.79, + 2124.962, + 935.6930000000002 + ], + "priority": 6, + "parents": [ + 33516 + ], + "children": [], + "area": 202063.69973, + "iscrowd": 0, + "segmentation": [], + "text": "Subjects & Paradigm: 110 healthy young adults (53 male, 57 female, ali right-\nhanded, age range 19-31 yrs, mean age 24.37 + 2.397 yrs) performed a well-\nestablished self-referential processing task [2] (See Figure 1).\n\nfMRI acquisition: 500 T2* EPls with TR = 2s, TE = 35 ms, flip-a = 80°, matrix size 23\nx 64 x 64 and voxel size 3.1 x 3.1 x 4 (+1) mm were acquired on a 1.5T GE MRI,\nanatomical scanning was perfermed via PDI with matrix size 70 x 256 x 256.\n\nfMRI data analysis: Preprocessing included acquisition time correction (slice timing),\nspatial realignment, normalization and smoothing. Then, general linear modelling\n(GLM) [5] was used to identify the neural correlates of social processing in general as\nwell as those of self-reference and reference to others specifically. Finally, dynamic\ncausal modelling (DCM) [6] and Bayesian model selection (BMS) [7] were used to\nestimate effective connectivity in a three-region network as well as to infer on iis\nmodulation by self-reference and reference to others." + }, + { + "id": 33519, + "strid": "cfa2e2a9-6a84-4280-93c4-c255d9356426", + "image_id": 201815, + "image_name": "117727.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2305.842, + 1323.326, + 971.194, + 864.692 + ], + "priority": 7, + "parents": [ + 33516 + ], + "children": [ + 33520 + ], + "area": 3051380.6704920004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 33520, + "strid": "3d2664c4-d7f4-4335-ac68-e700a42a25bc", + "image_id": 201815, + "image_name": "117727.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2321.057, + 2198.161, + 910.3360000000002, + 68.46500000000015 + ], + "priority": 8, + "parents": [ + 33519 + ], + "children": [], + "area": 5102056.9761769995, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1: Types of trials in the SelfRef paradigm." + }, + { + "id": 33527, + "strid": "97a5158c-1ca6-49f9-b057-48f330135c41", + "image_id": 201815, + "image_name": "117727.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 48.435, + 2397.916, + 78.581, + 490.19399999999996 + ], + "priority": 9, + "parents": [ + 33540 + ], + "children": [ + 33522, + 33523, + 33521 + ], + "area": 116143.06146000001, + "iscrowd": 0, + "segmentation": [], + "text": "S\nole |91IO“" + }, + { + "id": 33522, + "strid": "1a4a8edc-7b67-4dc4-85aa-121186a24805", + "image_id": 201815, + "image_name": "117727.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 155.523, + 2289.449, + 1181.661, + 659.2959999999998 + ], + "priority": 10, + "parents": [ + 33527 + ], + "children": [ + 33526 + ], + "area": 356061.976827, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 33526, + "strid": "9eb250e8-476a-456f-8fea-c0f9ca08dd01", + "image_id": 201815, + 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"segmentation": [], + "text": "Figure 4: Major activations in ihe task." + }, + { + "id": 33534, + "strid": "44c6f5c1-cfb8-4b11-aa02-3e2b7e4feaa5", + "image_id": 201815, + "image_name": "117727.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 40.342, + 3270.366, + 107.65500000000002, + 467.7420000000002 + ], + "priority": 16, + "parents": [ + 33540 + ], + "children": [ + 33530, + 33528, + 33529 + ], + "area": 131933.10517199998, + "iscrowd": 0, + "segmentation": [], + "text": "SoiweUuAg" + }, + { + "id": 33528, + "strid": "e0662054-e7d0-44e9-a9c3-27da5f5153d8", + "image_id": 201815, + "image_name": "117727.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 156.535, + 3041.321, + 987.456, + 719.8029999999999 + ], + "priority": 17, + "parents": [ + 33534 + ], + "children": [ + 33533 + ], + "area": 476073.182735, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 33533, + "strid": "2d04e326-0e53-4fb1-80f3-e85bddb5dfb3", + "image_id": 201815, + 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The\nwhole model space contains 28 = 256 DCMs. All\nmodels with no modulation by one of the experimen-\ntal conditions, i.e. 31 DCMs, were not considered." + }, + { + "id": 33529, + "strid": "85f399b6-cfa5-4e98-9d89-97515e05796f", + "image_id": 201815, + "image_name": "117727.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1221.948, + 3043.92, + 990.0539999999999, + 722.402 + ], + "priority": 19, + "parents": [ + 33534 + ], + "children": [ + 33532 + ], + "area": 3719511.9561600005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 33532, + "strid": "e5b0d493-612d-4769-8087-ac7bd022ef14", + "image_id": 201815, + "image_name": "117727.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1228.258, + 3769.663, + 972.6069999999997, + 204.17300000000023 + ], + "priority": 20, + "parents": [ + 33529 + ], + "children": [], + "area": 4630118.737054001, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 6; Hypothesis. It was suspected that self-\nreference and reference to others _ positively\nmodulate the pathes to ACC and PCC the rate of agreement\nbetween the Ci, defined according to tertiles of\nthe sample, swith other anthropometric\nparameters was analyzed, the results were\nsimilar." + }, + { + "id": 74496, + "strid": "0832f05c-cd09-4888-b113-ff2c2547d9a8", + "image_id": 203404, + "image_name": "120173.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1418.949, + 2529.253, + 1520.569, + 606.1730000000002 + ], + "priority": 9, + "parents": [ + 74488 + ], + "children": [], + "area": 3588881.015097, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 74497, + "strid": "485a7ddc-dbcd-4677-af8b-070813dc215d", + "image_id": 203404, + "image_name": "120173.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2956.483, + 2529.298, + 540.951, + 581.2660000000001 + ], + "priority": 10, + "parents": [ + 74488 + ], + "children": [], + "area": 7477826.538934, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 74498, + "strid": "9aa3a207-ce51-4bd9-9626-e940c29b8f6c", + "image_id": 203404, + "image_name": "120173.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1424.666, + 3149.332, + 1484.624, + 221.8470000000002 + ], + "priority": 11, + "parents": [ + 74488 + ], + "children": [], + "area": 4486746.223111999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 74499, + "strid": "01ebefa2-61ff-423c-9827-9b351ea765aa", + "image_id": 203404, + "image_name": "120173.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2961.234, + 3144.421, + 492.9409999999998, + 181.1880000000001 + ], + "priority": 12, + "parents": [ + 74488 + ], + "children": [], + "area": 9311366.375513999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 74500, + "strid": "e6a3a10a-3715-46b1-9a1a-a70d2a645429", + "image_id": 203404, + "image_name": "120173.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 58.396, + 3464.494, + 663.145, + 669.0000000000005 + ], + "priority": 13, + "parents": [ + 74488 + ], + "children": [], + "area": 202312.59162400002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 74501, + "strid": "47442c26-3487-4a05-a78c-2d434318bba5", + "image_id": 203404, + "image_name": "120173.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 742.568, + 3464.434, + 694.973, + 669.1350000000002 + ], + "priority": 14, + "parents": [ + 74488 + ], + "children": [], + "area": 2572577.826512, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 74502, + "strid": "dfaebc07-06fa-4c8d-b0cd-8b1767d33457", + "image_id": 203404, + "image_name": "120173.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1458.443, + 3464.468, + 670.1209999999999, + 669.085 + ], + "priority": 15, + "parents": [ + 74488 + ], + "children": [], + "area": 5052729.103324, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 74503, + "strid": "f3f8785f-ef21-4114-817e-b8d25d67dc57", + "image_id": 203404, + "image_name": "120173.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2149.49, + 3464.486, + 666.9479999999999, + 669.0429999999997 + ], + "priority": 16, + "parents": [ + 74488 + ], + "children": [], + "area": 7446878.012139999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 74504, + "strid": "975f67db-aa38-4f9d-95a2-1556c1f0b5f2", + "image_id": 203404, + "image_name": "120173.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2836.316, + 3464.18, + 674.435, + 669.4100000000003 + ], + "priority": 17, + "parents": [ + 74488 + ], + "children": [], + "area": 9825509.16088, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 74489, + "strid": "59e10144-6a51-423c-bf58-36c6e30f6462", + "image_id": 203404, + "image_name": "120173.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 112.767, + 4190.985, + 596.6219999999998, + 71.42799999999988 + ], + "priority": 18, + "parents": [ + 74505 + ], + "children": [ + 74494 + ], + "area": 472604.8054949999, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 74494, + "strid": "c1e89a30-b6ff-4213-9076-fec2c4d7ad23", + "image_id": 203404, + "image_name": "120173.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 167.503, + 4368.495, + 3166.11, + 227.8069999999998 + ], + "priority": 19, + "parents": [ + 74489 + ], + "children": [], + "area": 731736.0179849999, + "iscrowd": 0, + "segmentation": [], + "text": "The Gi and BMI do not rank our patients with renal transplantation and obesity equally, as wellas the WHR.\nHowever, we found a good agreement between the Ci and WC differentiated by sex. With these data we\ndefined in our population a.Ci cutoff that allows us to identify any at risk patient with abdominal obesity." + }, + { + "id": 74490, + "strid": "c34b43f0-f43f-4491-901f-6b6ba25aa024", + "image_id": 203404, + "image_name": "120173.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 115.9, + 4717.549, + 613.862, + 70.86899999999969 + ], + "priority": 20, + "parents": [ + 74505 + ], + "children": [ + 74495 + ], + "area": 546763.9291000001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 74495, + "strid": "bb597374-6342-4d7a-8a92-d65a07e5d438", + "image_id": 203404, + "image_name": "120173.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 91.6, + 4871.983, + 3230.82, + 154.86200000000008 + ], + "priority": 21, + "parents": [ + 74490 + ], + "children": [], + "area": 446273.6428, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 97129, + "strid": "3c030290-cf7d-4b5e-8b4b-494bc6fea26c", + "image_id": 204255, + "image_name": "121733.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 159.84, + 102.85, + 395.5799999999999, + 274.89 + ], + "priority": -1, + "parents": [], + "children": [ + 97100, + 97103, + 97102, + 97098, + 97114, + 97097, + 97113, + 97128, + 97115, + 97101, + 97125, + 97099 + ], + "area": 16439.543999999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 97097, + "strid": "32790b43-2e72-4b50-a9c0-183850f728eb", + "image_id": 204255, + "image_name": "121733.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 600.913, + 587.212, + 2101.882, + 143.35799999999995 + ], + "priority": 1, + "parents": [ + 97129 + ], + "children": [], + "area": 352863.324556, + "iscrowd": 0, + "segmentation": [], + "text": "Does drowght make a difference?" + }, + { + "id": 97099, + "strid": "59ba8d30-c735-4ea3-9be3-8f453a8f4dca", + "image_id": 204255, + "image_name": "121733.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 752.704, + 1051.017, + 1796.1919999999998, + 63.246000000000095 + ], + "priority": 2, + "parents": [ + 97129 + ], + "children": [], + "area": 791104.699968, + "iscrowd": 0, + "segmentation": [], + "text": "Caroline Greiser, Lisa Schtler, Andreas Hemp and Hermann Behling" + }, + { + "id": 97098, + "strid": "2ec01879-8c82-40ce-b22a-4ad617f85538", + "image_id": 204255, + "image_name": "121733.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 181.38, + 920.308, + 2959.922, + 90.65300000000002 + ], + "priority": 3, + "parents": [ + 97129 + ], + "children": [], + "area": 166925.46503999998, + "iscrowd": 0, + "segmentation": [], + "text": "Vegetation and climate dynamics at Mt. Kilimanjaro’s drier northern slopes" + }, + { + "id": 97100, + "strid": "ee569d2f-1b37-4b75-8d8c-c7fb36173799", + "image_id": 204255, + "image_name": "121733.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 444.033, + 1244.579, + 318.84299999999996, + 46.865999999999985 + ], + "priority": 4, + "parents": [ + 97129 + ], + "children": [ + 97106, + 97104, + 97105 + ], + "area": 552634.147107, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 97104, + "strid": "d86f7a6e-9c5c-4b2c-8e2f-928c549cccdd", + "image_id": 204255, + "image_name": "121733.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 147.198, + 1320.245, + 916.573, + 181.98599999999988 + ], + "priority": 5, + "parents": [ + 97100 + ], + "children": [], + "area": 194337.42351, + "iscrowd": 0, + "segmentation": [], + "text": "The past is the key to the future\n\nWe_ investigate pollen of a sediment core from\nMt.Kilimanjaro in order to reconstruct vegetation and\nclimate history and predict future landscape dynamics." + }, + { + "id": 97105, + "strid": "b108fa80-631a-409e-bdc9-849e34feed0c", + "image_id": 204255, + "image_name": "121733.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 148.526, + 1520.828, + 912.588, + 263.01700000000005 + ], + "priority": 6, + "parents": [ + 97100 + ], + "children": [], + "area": 225882.49952800001, + "iscrowd": 0, + "segmentation": [], + "text": "Different ecosystems react differently\n\nIn previous studies pollen archives from the southern\nslopes were analyzed and now we add pollen data from\nthe northern slopes, which experience considerably less\nprecipitation and show a deviating vegetation zonation and\nspecies composition (HEMP, 2006a)" + }, + { + "id": 97106, + "strid": "784ea5e7-5769-47cd-ad50-2501eeb388b5", + "image_id": 204255, + "image_name": "121733.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 145.869, + 1798.457, + 919.2299999999999, + 305.5240000000001 + ], + "priority": 7, + "parents": [ + 97100 + ], + "children": [], + "area": 262339.12413300003, + "iscrowd": 0, + "segmentation": [], + "text": "Missing bamboo\n\nIn contrast to all other east African mountains with similar\nprecipitation and occurrence of large herbivores (e.g.\nelephants), Mt. Kilimanjaro lacks a bamboo belt\n(Sinarundinaria alpina; HEMP, 2006b). Via pollen analysis\nwe may prove the former presence of bamboo during more\nfavorable climatic conditions." + }, + { + "id": 97101, + "strid": "c3ea39f7-69c7-49e9-b866-1b6437a8deea", + "image_id": 204255, + "image_name": "121733.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1620.563, + 1254.054, + 295.547, + 60.92399999999998 + ], + "priority": 8, + "parents": [ + 97129 + ], + "children": [ + 97126, + 97127, + 97112 + ], + "area": 2032273.5124020004, + "iscrowd": 0, + "segmentation": [], + "text": "Study sites" + }, + { + "id": 97112, + "strid": "2e78d226-110d-4214-934c-d087277b1884", + "image_id": 204255, + "image_name": "121733.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1175.934, + 1318.708, + 1190.5109999999997, + 168.25600000000009 + ], + "priority": 9, + "parents": [ + 97101 + ], + "children": [], + "area": 1550713.573272, + "iscrowd": 0, + "segmentation": [], + "text": "Mt. Kilimanjaro is an inactive stratovolcano located in Tanzania south of the\nEquator. The climate is tropical diurnal with distinct dry and wet seasons,\ndriven by the northeast and much stronger southeast monsoon. (HEMP,\n\n2006b)." + }, + { + "id": 97126, + "strid": "4b309f03-f8f4-4b1d-9d27-a7006d75a71d", + "image_id": 204255, + "image_name": "121733.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1198.921, + 1512.341, + 556.231, + 430.086 + ], + "priority": 10, + "parents": [ + 97101 + ], + "children": [], + "area": 1813177.3840609998, + "iscrowd": 0, + "segmentation": [], + "text": "Bamboo Site - North\n\n2550 m asl\nmontane forest zone\n(within small bamboo stand of 3-4 ha)\nClimate: rather dry\n(lee side of mountain)\nAnnual precipitation: ~ 1020 mm\nMean annual temperature: 10 °C" + }, + { + "id": 97127, + "strid": "0a7d1ca3-3cdf-4555-8d87-d186d6b2365d", + "image_id": 204255, + "image_name": "121733.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1831.281, + 1511.106, + 482.578, + 431.5629999999999 + ], + "priority": 11, + "parents": [ + 97101 + ], + "children": [], + "area": 2767259.7067859997, + "iscrowd": 0, + "segmentation": [], + "text": "Weru Weru Site = South\n\n2650 m asl\nmontane forest zone\n(no bamboo in vicinity)\nClimate: rather wet\n(luv side of mountain)\nAnnual precipitation: ~ 2230 mm\nMean annual temperature: 9 °C" + }, + { + "id": 97102, + "strid": "906b850c-ba46-4f38-9ba9-4aa101b5e602", + "image_id": 204255, + "image_name": "121733.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2529.24, + 1248.869, + 557.3910000000001, + 46.664999999999964 + ], + "priority": 12, + "parents": [ + 97129 + ], + "children": [ + 97124, + 97111 + ], + "area": 3158689.4295599996, + "iscrowd": 0, + "segmentation": [], + "text": "Material and methods" + }, + { + "id": 97111, + "strid": "165a27b6-1ae4-47c0-885b-8f105d15e28c", + "image_id": 204255, + "image_name": "121733.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2467.197, + 1315.791, + 679.4780000000001, + 385.462 + ], + "priority": 13, + "parents": [ + 97102 + ], + "children": [], + "area": 3246315.607827, + "iscrowd": 0, + "segmentation": [], + "text": "We took a sediment core at each of the two\nstudy sites with ~ 2 m length and prepared\nsubsamples at every 2 cm (Weru Weru)\nand 10 cm (Bamboo) for pollen analysis\n(F4GRI & IVERSEN, 1989).\n\nAfter identification with a light microscope\npollen taxa were ascribed to corresponding\nvegetation zones they are presently found\nin (HEMP, 2006a)." + }, + { + "id": 97124, + "strid": "87f01156-0081-44f3-8bba-e42d030a1b50", + "image_id": 204255, + "image_name": "121733.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2469.628, + 1719.509, + 682.8759999999997, + 237.0440000000001 + ], + "priority": 14, + "parents": [ + 97102 + ], + "children": [ + 97123 + ], + "area": 4246547.572652, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 97123, + "strid": "5cd44e0a-c6d3-40f9-a662-be22b031745f", + "image_id": 204255, + "image_name": "121733.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2469.628, + 1964.403, + 502.346, + 23.547000000000025 + ], + "priority": 15, + "parents": [ + 97124 + ], + "children": [], + "area": 4851344.652084, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 1. Pollen grains of Podocarpus, Erica and Asteraceae" + }, + { + "id": 97114, + "strid": "0b527411-17a5-45af-8788-1cd96b5cd29e", + "image_id": 204255, + "image_name": "121733.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 149.419, + 2179.925, + 677.531, + 454.4209999999998 + ], + "priority": 16, + "parents": [ + 97129 + ], + "children": [ + 97122 + ], + "area": 325722.21357500006, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 97122, + "strid": "50f4582a-4979-48fc-a07e-0635305bf72e", + "image_id": 204255, + "image_name": "121733.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 153.965, + 2645.167, + 626.978, + 23.52500000000009 + ], + "priority": 17, + "parents": [ + 97114 + ], + "children": [], + "area": 407263.137155, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 2. Bamboo Site with Sinarundinaria alpina. Northern montane forest." + }, + { + "id": 97113, + "strid": "7d9e4b36-ad0b-46b9-a7db-282cba9652a0", + "image_id": 204255, + "image_name": "121733.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 892.57, + 2138.912, + 1530.596, + 524.9630000000002 + ], + "priority": 18, + "parents": [ + 97129 + ], + "children": [ + 97121 + ], + "area": 1909128.6838399998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 97121, + "strid": "0c978ca2-ab8e-4ec0-a782-418b53855228", + "image_id": 204255, + "image_name": "121733.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 916.162, + 2646.207, + 357.77700000000004, + 24.320000000000164 + ], + "priority": 19, + "parents": [ + 97113 + ], + "children": [], + "area": 2424354.297534, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 3. Vegetation belts at Mt. Kilimanjaro" + }, + { + "id": 97128, + "strid": "db8dd133-d21f-455f-96cf-2e8695e0ddfb", + "image_id": 204255, + "image_name": "121733.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 915.118, + 2673.593, + 1199.2650000000003, + 23.39300000000003 + ], + "priority": 20, + "parents": [ + 97129 + ], + "children": [], + "area": 2446653.078974, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 97125, + "strid": "09d086e9-a449-4063-883a-3adc51961dc2", + "image_id": 204255, + "image_name": "121733.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2471.511, + 2180.725, + 679.683, + 454.462 + ], + "priority": 21, + "parents": [ + 97129 + ], + "children": [ + 97120 + ], + "area": 5389685.825475, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 97120, + "strid": "9d05f00c-77fb-4f37-afb6-8718cf460d48", + "image_id": 204255, + "image_name": "121733.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2484.488, + 2646.086, + 432.8220000000001, + 24.152000000000044 + ], + "priority": 22, + "parents": [ + 97125 + ], + "children": [], + "area": 6574168.913967999, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 4. Weru Weru Site. Southern montaine forest." + }, + { + "id": 97115, + "strid": "7c54cad5-d5fb-4227-8378-fe7dac845c0b", + "image_id": 204255, + "image_name": "121733.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 84.543, + 2800.507, + 3150.285, + 776.4070000000002 + ], + "priority": 23, + "parents": [ + 97129 + ], + "children": [ + 97116 + ], + "area": 236763.26330100003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 97116, + "strid": "849cb251-9a30-4b12-a7c6-d6a6ef3a221c", + "image_id": 204255, + "image_name": "121733.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 174.535, + 3583.081, + 2381.295, + 24.01000000000022 + ], + "priority": 24, + "parents": [ + 97115 + ], + "children": [], + "area": 625373.042335, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 5. Pollen diagrams of the Bamboo (left) and Weru Weru (right; SCHULER, 2012) soil profiles. Pollen and spore percentages are plotted against core depth and age. Main pollen taxa are assigned to the vegetation zone they are presently found in. LGM=Late Glacial Maximum." + }, + { + "id": 97103, + "strid": "3717f6aa-ed34-4f3c-9265-61acd0f8e1ae", + "image_id": 204255, + "image_name": "121733.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1241.039, + 3669.129, + 785.454, + 58.11200000000008 + ], + "priority": 25, + "parents": [ + 97129 + ], + "children": [ + 97110, + 97109, + 97118, + 97117, + 97107, + 97108 + ], + "area": 4553532.185031, + "iscrowd": 0, + "segmentation": [], + "text": "First results and interpretation" + }, + { + "id": 97107, + "strid": "ce78fdad-3517-46ab-8f5f-3369c0352e73", + "image_id": 204255, + "image_name": "121733.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 171.19, + 3787.444, + 608.325, + 455.0999999999999 + ], + "priority": 26, + "parents": [ + 97103 + ], + "children": [], + "area": 648372.53836, + "iscrowd": 0, + "segmentation": [], + "text": "Bamboo not always missing?\n\nA large Poaceae pollen grain in the\nBamboo site record probably stems\nfrom bamboo. This would confirm\nbamboo occurrence at least at this\nparticular site through the entire\nHolocene. It peaks during the African\nclimate optimum (9 - 6 cal ka BP;\nRITCHIE ET. AL, 1985) which has\nprobably provided more appropriate\nprecipitation for bamboo." + }, + { + "id": 97117, + "strid": "625a4e28-44f1-494f-9bef-2d72f2a92874", + "image_id": 204255, + "image_name": "121733.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 801.546, + 3841.869, + 282.1299999999999, + 377.88899999999967 + ], + "priority": 27, + "parents": [ + 97103 + ], + "children": [ + 97119 + ], + "area": 3079434.729474, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 97119, + "strid": "fa70bbd3-1e18-4510-8da2-6c5a475b5b2a", + "image_id": 204255, + "image_name": "121733.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 804.045, + 4233.471, + 291.1160000000001, + 23.204999999999927 + ], + "priority": 28, + "parents": [ + 97117 + ], + "children": [], + "area": 3403901.1901949993, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 6. Bamboo (?) pollen (400 x )" + }, + { + "id": 97108, + "strid": "470d282f-16ac-4ca2-aaee-27f770c6df14", + "image_id": 204255, + "image_name": "121733.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 176.907, + 4269.988, + 903.34, + 116.63400000000001 + ], + "priority": 29, + "parents": [ + 97103 + ], + "children": [], + "area": 755390.7671160001, + "iscrowd": 0, + "segmentation": [], + "text": "Proving an entire bamboo belt requires this pollen grain\nreported also on other sites, which is planned for future\nanalysis." + }, + { + "id": 97109, + "strid": "ce9fafbe-b507-4d83-941e-0923b46f16ce", + "image_id": 204255, + "image_name": "121733.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1154.572, + 3796.592, + 1003.9649999999999, + 214.9720000000002 + ], + "priority": 30, + "parents": [ + 97103 + ], + "children": [], + "area": 4383438.818624, + "iscrowd": 0, + "segmentation": [], + "text": "Vegetation shifts on northern slopes\n\nChanging pollen composition throughout the Bamboo site profile\nsuggests that vegetation belts (as represented today) may have\nshifted up- and downslope due to climate variation during the last\n>20 000 years." + }, + { + "id": 97118, + "strid": "124dcb14-9983-4454-8cc8-6350fb6eddd3", + "image_id": 204255, + "image_name": "121733.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1157.173, + 4024.707, + 1003.3370000000002, + 410.37500000000045 + ], + "priority": 31, + "parents": [ + 97103 + ], + "children": [], + "area": 4657282.273311, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 97110, + "strid": "4dfd66cc-5122-4b48-ad9e-aca4ae902832", + "image_id": 204255, + "image_name": "121733.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2229.432, + 3792.018, + 944.5050000000001, + 584.3119999999999 + ], + "priority": 32, + "parents": [ + 97103 + ], + "children": [], + "area": 8454046.273775999, + "iscrowd": 0, + "segmentation": [], + "text": "Comparison with southern slope and other records\n\nOur first results show that the trends of pollen taxa are in line\nwith other pollen records (e.g. Weru Weru) and climate\nreconstructions in East Africa (SCHULER, 2012).\n\nThese similarities confirm the Bamboo site archive to be\nappropriate for more detailed analyses (e.g. higher resolution),\nwhich may reveal time lags of vegetation belt shifts at northern\nand southern slopes.\n\nOur findings are important for understanding the mountain’s\necosystems, which supports effective future biodiversity\nconservation and water resource management at\nMt.Kilimanjaro." + }, + { + "id": 89604, + "strid": "c18c8230-91be-4e5e-93db-3213048f27b9", + "image_id": 203978, + "image_name": "121256.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 545.86, + 122.64, + 155.23000000000002, + 162.63 + ], + "priority": -1, + "parents": [], + "children": [ + 89569, + 89571, + 89574, + 89575, + 89570, + 89573, + 89572 + ], + "area": 66944.27040000001, + 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Jean-Francois Gibrat+\n1 IFB-core, CNRS, INRA, INSERM, Inria, CEA, Université Paris-Saclay, 91190 Gif-sur-Yvette, France\nContact: jonathan.lorenzo@france-bioinformatique.fr" + }, + { + "id": 6684, + "strid": "3645ea39-2d07-44ad-901f-9d18d4fb4be0", + "image_id": 200768, + "image_name": "10942.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 171.707, + 546.173, + 226.365, + 48.24199999999996 + ], + "priority": 3, + "parents": [ + 6686 + ], + "children": [ + 6700 + ], + "area": 93781.727311, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 6700, + "strid": "965ba977-58c7-421b-8226-c5174f2d0374", + "image_id": 200768, + "image_name": "10942.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 39.873, + 612.487, + 3060.495, + 480.381 + ], + "priority": 4, + "parents": [ + 6684 + ], + "children": [], + "area": 24421.694150999996, + "iscrowd": 0, + "segmentation": [], + "text": "The BioDataCloud project tends towards the use of a 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+ 226.228 + ], + "priority": 1, + "parents": [ + 40257 + ], + "children": [], + "area": 11580.028188000002, + "iscrowd": 0, + "segmentation": [], + "text": "Population structure of Mycobacterium tuberculosis in\ntwo geographically distant areas of Argentina" + }, + { + "id": 40235, + "strid": "e5f75a3a-6b53-48f6-81f7-0ce274df2f1f", + "image_id": 202083, + "image_name": "118101.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 91.703, + 334.432, + 2161.229, + 107.89800000000002 + ], + "priority": 2, + "parents": [ + 40257 + ], + "children": [], + "area": 30668.417696000004, + "iscrowd": 0, + "segmentation": [], + "text": "Johana Monteserin', Ana Etchart?, Ana Reniero?, Beatriz L6pez', Viviana Ritacco?\n1INEI-ANLIS \"Dr C Malbrdn“; Buenos Aires, Hospital San Roque, Jujuy; 7Hospital Central, San Isidro; *CONICET, Argentina" + }, + { + "id": 40236, + "strid": "9bebfd86-0b24-47dc-be64-7bfde89ce3bb", + "image_id": 202083, + "image_name": "118101.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 203.542, + 565.374, + 371.35699999999997, + 72.82500000000005 + ], + "priority": 3, + "parents": [ + 40257 + ], + "children": [ + 40238 + ], + "area": 115077.354708, + "iscrowd": 0, + "segmentation": [], + "text": "Background" + }, + { + "id": 40238, + "strid": "5c56e03f-23ab-41c7-b39e-23faeecb4c2a", + "image_id": 202083, + "image_name": "118101.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 112.201, + 682.373, + 1181.16, + 679.327 + ], + "priority": 4, + "parents": [ + 40236 + ], + "children": [], + "area": 76562.932973, + "iscrowd": 0, + "segmentation": [], + "text": "Argentina is a large South American country with\ndiverse areas regarding physical geography,\nethnic composition and TB epidemiology. Jujuy,\nan Andean province predominantly inhabited by\nnative Americans, presents one of the highest TB\nrates in the country [1]. The cosmopolitan area\nof Buenos Aires in the pampas presents medium\nTB rates and receives migrants from highly TB\nendemic areas of Argentina and neighbor\ncountries." + }, + { + "id": 40237, + "strid": "383504be-a4a8-4624-bd00-82fdcf07a2d3", + "image_id": 202083, + "image_name": "118101.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 203.266, + 1478.238, + 259.76700000000005, + 71.894 + ], + "priority": 5, + "parents": [ + 40257 + ], + "children": [ + 40240 + ], + "area": 300475.525308, + "iscrowd": 0, + "segmentation": [], + "text": "Purpose" + }, + { + "id": 40240, + "strid": "5b7ea801-3fa9-4417-baf2-a211eb74e575", + "image_id": 202083, + "image_name": "118101.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 114.246, + 1577.466, + 1175.442, + 262.028 + ], + "priority": 6, + "parents": [ + 40237 + ], + "children": [], + "area": 180219.18063599998, + "iscrowd": 0, + "segmentation": [], + "text": "We present an insight into the Mycobacterium\ntuberculosis population structure in those two\nareas which are 1,600 km distant from each\nother." + }, + { + "id": 40244, + "strid": "cf3c82be-2e61-441b-a062-1acdb86a8848", + "image_id": 202083, + "image_name": "118101.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 203.095, + 1928.932, + 283.72299999999996, + 61.11400000000003 + ], + "priority": 7, + "parents": [ + 40257 + ], + "children": [ + 40241 + ], + "area": 391756.44454, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 40241, + "strid": "bd522641-2140-4dd7-aa43-9c83aaf4dc73", + "image_id": 202083, + "image_name": "118101.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 112.463, + 2031.428, + 1178.156, + 405.1099999999999 + ], + "priority": 8, + "parents": [ + 40244 + ], + "children": [], + "area": 228460.487164, + "iscrowd": 0, + "segmentation": [], + "text": "We analyzed 383 isolates (one per patient): 158\nwere obtained in Jujuy in 2011-2012, and 225\nwere collected in Buenos Aires in 2003-2007 and\n2010-2012. Spoligotyping [2] was used for\ngenotype assignation according to the SITVIT\nWEB database (http://www.pasteur-guadeloupe.fr:8081/SITVIT_ONLINE/)." + }, + { + "id": 40245, + "strid": "347b1148-5a11-46e2-8354-99a66bd1d53a", + "image_id": 202083, + "image_name": "118101.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 204.523, + 2523.085, + 258.312, + 71.69599999999991 + ], + "priority": 9, + "parents": [ + 40257 + ], + "children": [ + 40253, + 40250, + 40243, + 40247, + 40252, + 40249, + 40239, + 40242, + 40251 + ], + "area": 516028.913455, + "iscrowd": 0, + "segmentation": [], + "text": "Findings" + }, + { + "id": 40243, + "strid": "dcf4cd66-823a-4cf3-b3eb-4eef09c9f564", + "image_id": 202083, + "image_name": "118101.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 115.464, + 2625.022, + 1173.698, + 119.96900000000005 + ], + "priority": 10, + "parents": [ + 40245 + ], + "children": [], + "area": 303095.540208, + "iscrowd": 0, + "segmentation": [], + "text": "Overall frequencies of M. tuberculosis families\nare shown below" + }, + { + "id": 40249, + "strid": "2ee5a002-0ded-4fc2-a22d-c59924fc9427", + "image_id": 202083, + "image_name": "118101.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 124.379, + 2941.24, + 691.989, + 623.8620000000001 + ], + "priority": 11, + "parents": [ + 40245 + ], + "children": [], + "area": 365828.48996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 40252, + "strid": "5dba8cdb-a8de-486e-a193-684eb3a459e7", + "image_id": 202083, + "image_name": "118101.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 852.519, + 2882.666, + 466.6490000000001, + 624.8530000000001 + ], + "priority": 12, + "parents": [ + 40245 + ], + "children": [], + "area": 2457527.535654, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 40247, + "strid": "b4ce2f69-746e-45e8-a7ca-a90982cc8c25", + "image_id": 202083, + "image_name": "118101.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 112.622, + 3603.923, + 1179.371, + 551.5190000000002 + ], + "priority": 13, + "parents": [ + 40245 + ], + "children": [], + "area": 405881.016106, + "iscrowd": 0, + "segmentation": [], + "text": "In Jujuy the isolates displayed 56 different\nspoligotypes with the predominant shared types\nbeing SIT50 (H3) 17%, SIT33 (LAM3) 14% and\nS!IT42 (LAMY) 10%. Taken together, these 3 SITs\naccounted for 41% of all the cases from Jujuy.\nHaarlem strains were significantly more frequent\nIn Jujuy (p<0.001), and T strains less frequent\n(p<0.01), than in Buenos Aires." + }, + { + "id": 40239, + "strid": "56ace6ce-ecf1-4e40-adc2-4f8e7237cd30", + "image_id": 202083, + "image_name": "118101.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1462.818, + 577.788, + 1174.702, + 339.985 + ], + "priority": 14, + "parents": [ + 40245 + ], + "children": [], + "area": 845198.686584, + "iscrowd": 0, + "segmentation": [], + "text": "In Buenos Aires the most frequent shared types\nwere: SIT33 (LAM3) 11.5%, SIT5O (H3) 11%, SIT53\nT1 Ghana 11%, altogether gathering 33% of the\nstrains. Frequencies of spoligo lineages by area\npresented below." + }, + { + "id": 40251, + "strid": "14b3ab4c-8a9a-4dd6-bbe3-651aa6bb0a81", + "image_id": 202083, + "image_name": "118101.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1474.763, + 952.115, + 540.3899999999999, + 881.512 + ], + "priority": 15, + "parents": [ + 40245 + ], + "children": [], + "area": 1404143.9737449999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 40253, + "strid": "caa4349e-262b-43d0-b912-57e99b50477f", + "image_id": 202083, + "image_name": "118101.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2072.006, + 1063.547, + 573.4429999999998, + 511.154 + ], + "priority": 16, + "parents": [ + 40245 + ], + "children": [], + "area": 2203675.765282, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 40242, + "strid": "2787494c-337b-400c-a3e4-cc6f5990c782", + "image_id": 202083, + "image_name": "118101.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1461.312, + 1895.54, + 1175.391, + 477.933 + ], + "priority": 17, + "parents": [ + 40245 + ], + "children": [], + "area": 2769975.3484799997, + "iscrowd": 0, + "segmentation": [], + "text": "Of the 26 SlT-orphan strains found in the study,\n18 were grouped in 8 local clusters of 2-5\nisolates. None of the S!T-orphan clustered strains\nmatched any of the >1000 spoligotypes from\nother Ibero-American countries deposited in our\ndatabase, suggesting that those SlIT-orphan\ngenotypes might be autochthonous." + }, + { + "id": 40250, + "strid": "25cbdd46-3031-42f0-adbe-2e6c0b616ac5", + "image_id": 202083, + "image_name": "118101.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1561.247, + 2416.04, + 1037.845, + 729.9409999999998 + ], + "priority": 18, + "parents": [ + 40245 + ], + "children": [], + "area": 3772035.20188, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 40246, + "strid": "3b4c6a03-1106-413c-9221-14ffd95cdcfd", + "image_id": 202083, + "image_name": "118101.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1584.304, + 3188.892, + 372.0930000000001, + 60.88700000000017 + ], + "priority": 19, + "parents": [ + 40257 + ], + "children": [ + 40248 + ], + "area": 5052174.351168, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 40248, + "strid": "732d7a1c-2d5f-45b7-a0fe-81d3650bdb6b", + "image_id": 202083, + "image_name": "118101.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1478.216, + 3277.864, + 1160.221, + 547.6869999999999 + ], + "priority": 20, + "parents": [ + 40246 + ], + "children": [], + "area": 4845391.010624, + "iscrowd": 0, + "segmentation": [], + "text": "The overall MM. tuberculosis genotype\ndistribution observed in Argentina is in range\nwith that reported for other South American\ncountries. The abundance of SIT50 (H3) in Jujuy\nis congruent with a similar finding in Bolivia [3],\na close neighbor country bearing intensive\ncross-border transit with Jujuy." + }, + { + "id": 40256, + "strid": "8bd0da49-cbd3-40b9-8b29-2a74ebf72524", + "image_id": 202083, + "image_name": "118101.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1584.763, + 3855.186, + 155.269, + 28.38500000000022 + ], + "priority": 21, + "parents": [ + 40257 + ], + "children": [ + 40254, + 40255 + ], + "area": 6109556.130918, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 40254, + "strid": "9af2cf85-3ca7-423a-965d-c49bca05a95f", + "image_id": 202083, + "image_name": "118101.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1483.797, + 3900.71, + 1150.996, + 192.5369999999998 + ], + "priority": 22, + "parents": [ + 40256 + ], + "children": [], + "area": 5787861.7958700005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 40255, + "strid": "94706b56-d53d-4ebc-8df9-88d3200c1c1c", + "image_id": 202083, + "image_name": "118101.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1592.497, + 4138.698, + 1043.1449999999998, + 30.850999999999658 + ], + "priority": 23, + "parents": [ + 40256 + ], + "children": [], + "area": 6590864.148906001, + "iscrowd": 0, + "segmentation": [], + "text": "JM holds doctoral fellowship granted by project PAE-PICT 200602323, FonCyT, Argentina" + }, + { + "id": 52135, + "strid": "05edd080-cffe-43f0-a484-2cfe769a6396", + "image_id": 202552, + "image_name": "118863.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 396.77, + 201.65, + 399.1700000000001, + 340.03 + ], + "priority": -1, + "parents": [], + "children": [ + 52121, + 52122, + 52131, + 52123, + 52126, + 52125, + 52127, + 52124 + ], + "area": 80008.6705, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 52121, + "strid": "a75df7c7-f802-44c8-a065-840d45f40e8d", + "image_id": 202552, + "image_name": "118863.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 932.801, + 113.474, + 3212.016, + 122.23799999999999 + ], + "priority": 1, + "parents": [ + 52135 + ], + "children": [], + "area": 105848.66067400001, + "iscrowd": 0, + "segmentation": [], + "text": "An assessment offpain reports in ALS using three large data sets" + }, + { + "id": 52122, + "strid": "74eb90c4-8bad-4df0-88f4-e80d8c4cd5b3", + "image_id": 202552, + "image_name": "118863.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 936.108, + 298.911, + 3510.459, + 243.55400000000003 + ], + "priority": 2, + "parents": [ + 52135 + ], + "children": [], + "area": 279812.978388, + "iscrowd": 0, + "segmentation": [], + "text": "Helen E Stephens’, Stephanie Felgoise?, Susan Walsh?, Zachary Simmons!‘\n\n‘Penn State Hershey Medical Center, Philadelphia College of Osteopathic Medicine, ‘ALS Association Greater\nPhiladelphia Chapter" + }, + { + "id": 52123, + "strid": "011dd451-dc3b-4b9e-ab72-7662721e8d78", + "image_id": 202552, + "image_name": "118863.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 129.239, + 635.442, + 518.468, + 94.21199999999999 + ], + "priority": 3, + "parents": [ + 52135 + ], + "children": [ + 52128 + ], + "area": 82123.888638, + "iscrowd": 0, + "segmentation": [], + "text": "Background" + }, + { + "id": 52128, + "strid": "8c710593-7389-4ca2-b8a9-620bda0099f1", + "image_id": 202552, + "image_name": "118863.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 123.428, + 734.824, + 1457.476, + 1059.3889999999997 + ], + "priority": 4, + "parents": [ + 52123 + ], + "children": [], + "area": 90697.856672, + "iscrowd": 0, + "segmentation": [], + "text": "ALS has generally been considered a painless disorder,\nbut recent studies have shown that pain is.a frequently\nunderestimated and under-reported symptom in ALS, more\nso in the late stages of the disease.\n\nPrevious studies have documented a prevalence of pain in\npatients with ALS of up to 70% at some time during the\ncourse of the disease.(1)(2) This pain can be due to\nmusculoskeletal causes, cramps, or spasticity.\n\nThe ALS Specific Quality of Life-Revised (ALSSQOLR)\ninstrument is a disease-specific, validated measure of\nquality of life (QOL). One item within the measure\naddresses self-reported problematic pain by asking “how\nmuch of a problem has pain been in the last 7 days” using\na scale of 0 (no problem) to 10 (tremendous problem)." + }, + { + "id": 52124, + "strid": "33009eb0-78af-40ca-89e9-fba83a9bc1f7", + "image_id": 202552, + "image_name": "118863.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 125.12, + 1875.038, + 452.84399999999994, + 90.39699999999993 + ], + "priority": 5, + "parents": [ + 52135 + ], + "children": [ + 52129 + ], + "area": 234604.75456, + "iscrowd": 0, + "segmentation": [], + "text": "Objectives" + }, + { + "id": 52129, + "strid": "ba7342e3-10f0-4bd8-8406-94833919487f", + "image_id": 202552, + "image_name": "118863.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 128.638, + 1972.955, + 1392.733, + 127.82000000000016 + ], + "priority": 6, + "parents": [ + 52124 + ], + "children": [], + "area": 253796.98529, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 52125, + "strid": "2fee70ad-9241-4ab6-b180-c66df1ad1af8", + "image_id": 202552, + "image_name": "118863.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 124.259, + 2218.546, + 373.64, + 80.92700000000013 + ], + "priority": 7, + "parents": [ + 52135 + ], + "children": [ + 52130 + ], + "area": 275674.307414, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 52130, + "strid": "f6061260-a385-42af-91b4-6cd4d7125e53", + "image_id": 202552, + "image_name": "118863.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 115.831, + 2319.654, + 1441.392, + 935.739 + ], + "priority": 8, + "parents": [ + 52125 + ], + "children": [], + "area": 268687.842474, + "iscrowd": 0, + "segmentation": [], + "text": "A retrospective review was carried out of 3 large research\ndata sets used to collect ALSSQOLR, ALS Functional\nRating Scale-Revised (ALSFRSR), and demographic data\nfrom ALS patients. This included a multicenter dataset\ncollected at 12 US academic ALS clinics in 2006 (DATA1)\nas part of a validation study of the ALSSQOLR, and 2\nnational survey data sets of ALS patients who completed\nquestionnaires in 2007 (DATA2) and 2009 (DATAS3) in\nsurveys comparing those who attended multidisciplinary\nclinics to those who did not. We created pain problem\nseverity categories based on patient problem ratings: 0 =\nno problem; 1-3 = mild problem; 4-6 = moderate problem;\n7-10 = severe problem. Pearson product-moment\ncorrelations between pain and ALSFRSR were calculated." + }, + { + "id": 52127, + "strid": "ef7de293-90cb-4cb7-9110-7d26497f964d", + "image_id": 202552, + "image_name": "118863.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1786.743, + 647.535, + 324.93499999999995, + 84.04600000000005 + ], + "priority": 9, + "parents": [ + 52135 + ], + "children": [ + 52134, + 52133 + ], + "area": 1156978.628505, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 52133, + "strid": "78bb3382-cd62-4987-9a52-3ad8b55f8dac", + "image_id": 202552, + "image_name": "118863.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1778.29, + 745.5, + 2849.5379999999996, + 733.8499999999999 + ], + "priority": 10, + "parents": [ + 52127 + ], + "children": [], + "area": 1325715.195, + "iscrowd": 0, + "segmentation": [], + "text": "There were 389 patients in DATA 1, 381 in DATA2 and 385 in DATA 3. All 3 data sets had similar distributions of\ngender (approximately 60% male), site of disease onset (25% bulbar, 75% limb), and mean age (approximately 57\nyears). Mean ALSFRSR in the 3 sets was: 33/48 (DATA1), 26/48 (DATA 2).and 28/48 (DATA 3). Mean ratings of\npain were 2.2 (SD=2.7) in DATA1, 2:7 (SD=2.9) in DATA 2, and 2.6 (SD=2.8) in DATAS.\n\nProblematic pain was common in all 3 data sets. Some degree of problematic pain was reported in 60% of patients\nin DATA1, 64% in DATA2, and 66% in DATA3. The three data sets show similar distributions of pain report scores\n(see Graph 1). Approximately 35% of the patients report pain to be mild while 25-30% experience moderate to\nsevere problematic pain. A negative correlation (p<.05) of ALSFRSR and pain was present in ail samples r= -.16\n(DATA1), r=-.15 (DATA2), and r=-.14 (DATA3) such that higher functional scores via ALSFRSR are related to lower\nratings of problematic pain." + }, + { + "id": 52134, + "strid": "daa0315d-487b-4252-af04-6ee77213cc00", + "image_id": 202552, + "image_name": "118863.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2023.527, + 1559.426, + 2410.2379999999994, + 807.5390000000002 + ], + "priority": 11, + "parents": [ + 52127 + ], + "children": [], + "area": 3155540.615502, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 52126, + "strid": "55192a5e-4efd-4aaf-b7d6-e53bedd8e1ec", + "image_id": 202552, + "image_name": "118863.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1794.445, + 2416.171, + 534.6490000000001, + 75.94399999999996 + ], + "priority": 12, + "parents": [ + 52135 + ], + "children": [ + 52132 + ], + "area": 4335685.970094999, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 52132, + "strid": "5ab453b6-1d65-4668-9fdc-220a843ef0a8", + "image_id": 202552, + "image_name": "118863.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1791.183, + 2510.254, + 2896.183, + 473.9250000000002 + ], + "priority": 13, + "parents": [ + 52126 + ], + "children": [], + "area": 4496324.2904819995, + "iscrowd": 0, + "segmentation": [], + "text": "Pain is common in patients with ALS. When present, pain was rated as moderate or severe in nearly 40% of patients.\nPoorer physical function was associated with more problematic pain, consistent with previous studies. (2)(3)\n\nPatients with ALS should be asked and encouraged to report pain.\n\nAdditional large, prospective studies to characterize the nature, distribution, and severity of pain in ALS are being\nplanned by our team and we hope will aid in the development of systematic approaches for pain management." + }, + { + "id": 52131, + "strid": "fdd26ab3-2c81-4a1d-9156-244da3fde2b7", + "image_id": 202552, + "image_name": "118863.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1789.818, + 3059.522, + 2748.227, + 401.3649999999998 + ], + "priority": 14, + "parents": [ + 52135 + ], + "children": [], + "area": 5475987.546996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 96338, + "strid": "b9649e7c-eb07-4ab6-9c8d-d70d231f24b0", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 78.55, + 165.18, + 330.2, + 160.38 + ], + "priority": -1, + "parents": [], + "children": [ + 96308, + 96310, + 96303, + 96309, + 96307, + 96306, + 96304, + 96311, + 96305 + ], + "area": 12974.889, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 96303, + "strid": "9fa8e96a-86c1-43f6-9aff-41f70aad4d6f", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 376.735, + 486.443, + 2387.519, + 834.328 + ], + "priority": 1, + "parents": [ + 96338 + ], + "children": [], + "area": 183260.103605, + "iscrowd": 0, + "segmentation": [], + "text": "— Tocilizumab i\ncontributes to the\nresolution of inflammation\nby affecting the migratory behavior\nof monocytes in the synovial lining" + }, + { + "id": 96304, + "strid": "84a24c0f-b210-48ca-ba2c-67935cb120b5", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 387.909, + 1348.972, + 2578.01, + 255.40699999999993 + ], + "priority": 2, + "parents": [ + 96338 + ], + "children": [], + "area": 523278.379548, + "iscrowd": 0, + "segmentation": [], + "text": "Ruth A. Byrne’, Karolina v. Dalwigk?, Johannes Holinka?, Ginter Steiner’,\nJosef Smolen’, Hans P. Kiener? and Clemens Scheinecker’*\n‘Div. of Rheumatology, Dep. of Med. III, 7Dep. of Orthopedics, Medical University Vienna, Vienna, Austria" + }, + { + "id": 96305, + "strid": "12932391-e1ca-4ffa-9a18-a3e6a03bbbc0", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 373.203, + 1684.015, + 284.082, + 61.083000000000084 + ], + "priority": 3, + "parents": [ + 96338 + ], + "children": [ + 96330, + 96312 + ], + "area": 628479.450045, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 96312, + "strid": "f50813c9-bbeb-47a3-9411-9d721732dd86", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 132.569, + 1789.674, + 1049.217, + 600.3069999999998 + ], + "priority": 4, + "parents": [ + 96305 + ], + "children": [], + "area": 237255.29250599997, + "iscrowd": 0, + "segmentation": [], + "text": "Monocytes (Mo) are among the first\nhematopoietic cells to migrate into the inflamed\nsynovial tissue. There they integrate into the\nsynovial lining network of fibroblast-like synovial\ncells (FLS).\nHere we analyze the dependence of Mo — FLS\ninteraction on proinflammatory cytokines using real\ntime confocal/multiphoton microscopy of 3D\nmicromass tissue cultures (ig. 4).\nWe hypothesize that Tumor Necrosis Factor-alpha (TNF)\nstimulates FLS to produce II-6, which in turn stimulates\nMo to migrate (Fig. 2)." + }, + { + "id": 96330, + "strid": "46480b09-fcb7-4dfd-900c-418cfeb0b04e", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 131.836, + 2530.079, + 994.932, + 324.259 + ], + "priority": 5, + "parents": [ + 96305 + ], + "children": [ + 96328, + 96313 + ], + "area": 333555.49504400004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 96328, + "strid": "5bbe83f9-b08e-4371-9161-9156d7732200", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 135.145, + 2452.681, + 139.66600000000003, + 44.57400000000007 + ], + "priority": 6, + "parents": [ + 96330 + ], + "children": [], + "area": 331467.573745, + "iscrowd": 0, + "segmentation": [], + "text": "Figure |" + }, + { + "id": 96313, + "strid": "ca99ee68-0549-41c8-a169-883abb76867c", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 131.814, + 2873.094, + 983.3270000000001, + 309.3330000000001 + ], + "priority": 7, + "parents": [ + 96330 + ], + "children": [], + "area": 378714.01251599996, + "iscrowd": 0, + "segmentation": [], + "text": "A) Human joint. Left section healthy, right section inflammed\nCONAITION (Smolen & Steiner, Nat. Rev. Drug Disc. 2003, 2, 473-488)\n\nB) Tissue organization of the ne) lining. The extracellular\nMe is inhabited by FLS and macrophage-like synoviocytes\n\nQO).\n\n) Immunohistochemical cross-section of a micromass\nco-culture. FLS build a dens lining Se and a more loosely\norganized sublining. Mo (brown — CD45) were integrated\ninto the lining layer." + }, + { + "id": 96306, + "strid": "f47efeb0-ef78-4c28-b4e4-c7236b352735", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 125.907, + 3263.286, + 972.666, + 106.00199999999995 + ], + "priority": 8, + "parents": [ + 96338 + ], + "children": [ + 96315, + 96331, + 96336, + 96327, + 96314, + 96332 + ], + "area": 410870.550402, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 96314, + "strid": "0bf895c5-cc64-4cbb-ae5b-67f8a7c10fc9", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 126.785, + 3417.571, + 811.056, + 100.596 + ], + "priority": 9, + "parents": [ + 96306 + ], + "children": [], + "area": 433296.739235, + "iscrowd": 0, + "segmentation": [], + "text": "Cell behavior could be subdivided into three\nsuccessive phases as described in Fig. 3." + }, + { + "id": 96331, + "strid": "2fa0997a-42f0-4592-8755-7504a6e6c699", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 129.822, + 3539.11, + 992.918, + 251.7539999999999 + ], + "priority": 10, + "parents": [ + 96306 + ], + "children": [ + 96322 + ], + "area": 459454.33842000004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 96322, + "strid": "a1d587c0-897c-4e7d-b621-3a70953c0242", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 128.224, + 3810.88, + 1002.9660000000001, + 270.3919999999998 + ], + "priority": 11, + "parents": [ + 96331 + ], + "children": [], + "area": 488646.27712, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3\n\nA) Phase |: Day 1 - 2. FLS_in process of lining layer formation,\nIN KeKe Is e][e Varo] (el all ale .el- aie \\/(0)] un ;\n| Phase II: Day 3 - 7. FLS organized into lining architecture,\n\n© show a variety of behaviors like fast moving cells travelling\nover long distances and clustering. a\nC) Phase Ill: Day 8 - 14. Mo show no activity." + }, + { + "id": 96315, + "strid": "f5fa1488-30d4-4704-9c62-ac2c0f1e2119", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 125.347, + 4118.211, + 1022.4280000000001, + 541.902 + ], + "priority": 12, + "parents": [ + 96306 + ], + "children": [], + "area": 516205.394217, + "iscrowd": 0, + "segmentation": [], + "text": "From day 4 of culture onward the majority of MO\nremained sessile, whereas a fraction of Mo displayed\na directed cell movement with an impressive maximum\nspeed of up to 15 um/min (Fig. 42).\n\nThese moving monocytes were 95,5 % in close contact\nwith fibroblasts. However, they did not follow individual\nfibroblast but rather moved rapidly across the surface\nof the tissue. In addition, the formation of Mo cell\nclusters was observed (ig. 45). Cells in clusters\nshowed adjoined movement and clusters consisted of\n2 -9 cells." + }, + { + "id": 96332, + "strid": "0f7c3efb-4c7a-43e3-8ac9-6a3a0f9a449d", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 119.752, + 4727.389, + 680.743, + 618.308 + ], + "priority": 13, + "parents": [ + 96306 + ], + "children": [ + 96316 + ], + "area": 566114.287528, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 96316, + "strid": "20bff992-f710-4cb6-8b19-6c55b35b16ea", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 825.741, + 4740.984, + 295.83500000000004, + 603.6700000000001 + ], + "priority": 14, + "parents": [ + 96332 + ], + "children": [], + "area": 3914824.869144, + "iscrowd": 0, + "segmentation": [], + "text": "ell kcwe\n\nnN\n\nTrack of one\nrapidly moving Mo\nacross the\nmicromass surface.\n\nB\n\nRepresentative\ncluster of Mo.\n\nThe cells' tracks\nshow adjoined\nmovements that\nare directed\naround each other\nover time." + }, + { + "id": 96336, + "strid": "5b2ac608-2d61-4628-8e5c-2973dd14fd4c", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1270.875, + 1797.673, + 1098.8890000000001, + 496.3889999999999 + ], + "priority": 15, + "parents": [ + 96306 + ], + "children": [ + 96329 + ], + "area": 2284617.673875, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 96329, + "strid": "913869ca-415c-4afc-a687-29db0949749a", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1275.634, + 1703.497, + 146.82799999999997, + 43.690000000000055 + ], + "priority": 16, + "parents": [ + 96336 + ], + "children": [], + "area": 2173038.692098, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 96327, + "strid": "c8b47db4-531e-473f-a5ee-eb82019b9055", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1269.982, + 2323.713, + 1038.676, + 75.7170000000001 + ], + "priority": 17, + "parents": [ + 96306 + ], + "children": [], + "area": 2951073.683166, + "iscrowd": 0, + "segmentation": [], + "text": "TNF stimulates FLS to produce IL-6, which in turn stimulates Mo to\nmigrate. Tocilizumab blocks the effect of IL-6." + }, + { + "id": 96308, + "strid": "6985babd-cedf-4ea8-a29b-73b2797af3c8", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1268.848, + 2482.481, + 1001.0230000000001, + 111.35800000000017 + ], + "priority": 18, + "parents": [ + 96338 + ], + "children": [ + 96320, + 96337, + 96334 + ], + "area": 3149891.051888, + "iscrowd": 0, + "segmentation": [], + "text": "and IL-6 on" + }, + { + "id": 96320, + "strid": "e8905d18-88d5-4743-86c0-825d5a6bfb20", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1267.201, + 2639.826, + 1086.982, + 551.1610000000001 + ], + "priority": 19, + "parents": [ + 96308 + ], + "children": [], + "area": 3345190.147026, + "iscrowd": 0, + "segmentation": [], + "text": "TNF stimulated Mo prolonged their activity into Phase Ill.\nFig. 5ab shows that both fast moving cells as well as cell\nclusters frequently occurred on days 8 - 12.\n\nAdditionally, a new behavior of closely interacting cells\nbecame apparent (Fig. 5c). These cell bodies were\nintimately adjoined and oscillated towards each other.\nThey were connecting via cellular protrusions (\"'g. 6).\nIL-6 stimulation resulted in similar Mo behavior. The\npercentage of moving Mo is comparable to TNF stimulated\ncells and much higher than in the control setting (Fig. 7a).\nAlso, a similar number of cell clusters was found (Fig. 7)." + }, + { + "id": 96334, + "strid": "634053e5-2ef8-435f-acc7-371342fe965c", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1565.522, + 3271.306, + 713.5889999999999, + 716.5009999999997 + ], + "priority": 20, + "parents": [ + 96308 + ], + "children": [ + 96324 + ], + "area": 5121301.511732, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 96324, + "strid": "ec37b8cf-9174-447f-8cd2-f90fc2f9024d", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1268.436, + 3269.462, + 240.61899999999991, + 373.3420000000001 + ], + "priority": 21, + "parents": [ + 96334 + ], + "children": [], + "area": 4147103.3014319995, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 6\n\nExample for a\nconnecting\nMo-Mo cluster.\nCells conduct\noscillating\nmovements\n1Ke\\,Z0 [Koka 1e[e18]\nother." + }, + { + "id": 96337, + "strid": "2c703e99-5b9a-4c54-90d7-305050b8654b", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1267.374, + 4288.134, + 1001.3569999999997, + 325.116 + ], + "priority": 22, + "parents": [ + 96308 + ], + "children": [ + 96323 + ], + "area": 5434669.540116, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 96323, + "strid": "8b779584-95ff-416b-a853-c1c900d56fa3", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1264.814, + 4021.534, + 1064.276, + 212.2260000000001 + ], + "priority": 23, + "parents": [ + 96337 + ], + "children": [], + "area": 5086492.504676, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 7\n\nA) While the activity of Mo in the control setting decreases, both TNF as\n\nHe as IL-6 Smtr ete high numbers of moving cells (Day 7).\neee on day 7 of culture cell clusters could be found in TNF and\nSe CRESS MM ae ai mtalReoh lice) cyt en" + }, + { + "id": 96307, + "strid": "60e0d834-04eb-416d-a601-109624e49de1", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1258.977, + 4694.602, + 208.1790000000001, + 61.50699999999961 + ], + "priority": 24, + "parents": [ + 96338 + ], + "children": [ + 96317 + ], + "area": 5910395.9421540005, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 96317, + "strid": "f0cb1f6a-fd1c-43f4-9776-53f91e50e113", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1257.628, + 4797.597, + 1053.198, + 756.1810000000005 + ], + "priority": 25, + "parents": [ + 96307 + ], + "children": [], + "area": 6033592.319916, + "iscrowd": 0, + "segmentation": [], + "text": "Human FLS were prepared from synovial tissues obtained\nas discarded specimens following joint arthroplasty. CD14+\nMo were isolated from peripheral blood by magnetic bead\nsorting.\n\nFor confocal imaging fluorescent labeled FLS and Mo were\ncultured in spherical extracellular matrix micromasses.\nThese cell cultures were analyzed in two control, two TNF\nand one IL-6 timeseries giving an overview of the cells\nbehavior between Day 1 — 14 of culture. Additional\nmicromasses were treated with TNF&Tocilizumab and\nTNF&lgG1 on Day 4 of culture. All cell cultures were\ntreated 1h or directly before scanning to show short term\neffects.\n\nThe resulting 4D live cell imaging movies were analyzed with\nImaris® Software. The parameters track length, cell speed\nand motility index (MI) were used to describe cell behavior.\nThe MI is described as the distance a cell traveled (vector\nfrom starting to end point) divided by the track length." + }, + { + "id": 96309, + "strid": "724ba424-b849-4e4b-8ffe-9697ebbee081", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2475.222, + 1688.437, + 252.99000000000024, + 61.29899999999998 + ], + "priority": 26, + "parents": [ + 96338 + ], + "children": [ + 96335, + 96321 + ], + "area": 4179256.408014, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 96321, + "strid": "a83f68ea-bb45-4dbb-92be-d37e684bb415", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2474.35, + 1793.909, + 953.3009999999999, + 304.9830000000002 + ], + "priority": 27, + "parents": [ + 96309 + ], + "children": [], + "area": 4438758.73415, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 96335, + "strid": "c954eca8-e472-4edf-82a4-39580feb2d86", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2849.267, + 2173.163, + 600.2219999999998, + 667.7170000000001 + ], + "priority": 28, + "parents": [ + 96309 + ], + "children": [ + 96325 + ], + "area": 6191921.621521, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 96325, + "strid": "7a0affaf-536e-4f85-9c46-b8e56cbb4f22", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2470.827, + 2212.537, + 267.94000000000005, + 428.97400000000016 + ], + "priority": 29, + "parents": [ + 96335 + ], + "children": [], + "area": 5466796.158099, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 5\n\nComparison\nbetween control\nand TNF\nstimulated culture\ncondition for the\nabundance of\n\nA) moving Mo,\n\nB) Mo clusters,\nC)Mo-Mo\nconnecting pairs" + }, + { + "id": 96310, + "strid": "6836190c-b4b3-4b9f-b1d0-c804bf88a9ae", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2471.837, + 2940.72, + 711.692, + 110.43499999999995 + ], + "priority": 30, + "parents": [ + 96338 + ], + "children": [ + 96319, + 96333 + ], + "area": 7268980.50264, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 96319, + "strid": "df52363b-236b-44a9-bccc-dd86b48c1038", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2469.973, + 3099.409, + 979.3360000000002, + 400.7539999999999 + ], + "priority": 31, + "parents": [ + 96310 + ], + "children": [], + "area": 7655456.545957, + "iscrowd": 0, + "segmentation": [], + "text": "Micromasses cultured for 4 days were treated with\nTocilizumab or IgG1 (an antibody control) 1h prior\n\nto and additionally with TNF directly before scanning.\nIgG1 treatment resulted in similar behavior\ncompared to TNF/IL-6 stimulation as described\nabove. However, 3D cultures treated with\nTocilizumab showed a decreased fraction of moving\nMo (Fig. 8)." + }, + { + "id": 96333, + "strid": "288196f4-c918-44f2-8cc2-16c471275a28", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2480.938, + 3727.031, + 511.7289999999998, + 308.27 + ], + "priority": 32, + "parents": [ + 96310 + ], + "children": [ + 96326 + ], + "area": 9246532.835078001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 96326, + "strid": "cc7d493a-9375-41ee-8122-bfa82cfe83b8", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2477.493, + 3554.385, + 791.7950000000001, + 146.57799999999997 + ], + "priority": 33, + "parents": [ + 96333 + ], + "children": [], + "area": 8805963.956805, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 8\n\nTocilizumab decreases the number of moving cells as\ncompared to TNF treatment." + }, + { + "id": 96311, + "strid": "9af3651a-7e7d-414f-847f-9d910335ddc6", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2470.61, + 4118.694, + 292.0390000000002, + 62.57999999999993 + ], + "priority": 34, + "parents": [ + 96338 + ], + "children": [ + 96318 + ], + "area": 10175686.583340002, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 96318, + "strid": "92021757-8e82-48b2-a27a-948d5c3459fc", + "image_id": 204221, + "image_name": "121674.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2468.427, + 4226.294, + 927.4200000000001, + 700.1120000000001 + ], + "priority": 35, + "parents": [ + 96311 + ], + "children": [], + "area": 10432298.219538, + "iscrowd": 0, + "segmentation": [], + "text": "The 3D synovial tissue culture system allows to\nmonitor and analyze subtle migration patterns of\nMo in relation to the organized synovial lining\narchitecture.\n\nThe behaviors exhibited by Mo is altered by\n\nthe presence of proinflammatory cytokines.\n\nTNF and IL-6 cause significant changes in the\nmigratory behavior of Mo, ie. they enhance Mo\nmotility. Tocilizumab seems to abrogate this effect.\nOngoing experiments will address the molecular\nmechanism(s) of Mo — FLS interaction as well as\nthe cellular source and sequence of cytokine\nproduction in order to identify potential targets for\nfuture therapeutic interventions in arthritis." + }, + { + "id": 46824, + "strid": "6519804f-2caf-41f2-ad3f-63631526be70", + "image_id": 202331, + "image_name": "118558.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 198.13, + 79.29, + 192.19, + 184.79999999999995 + ], + "priority": -1, + "parents": [], + "children": [ + 46809, + 46799, + 46823, + 46800, + 46803, + 46804, + 46801, + 46806, + 46802, + 46805 + ], + "area": 15709.727700000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 46799, + "strid": "f8623642-6e64-4921-b6b9-15411afca847", + "image_id": 202331, + "image_name": "118558.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 592.605, + 52.276, + 2664.515, + 110.87199999999999 + ], + "priority": 1, + "parents": [ + 46824 + ], + "children": [], + "area": 30979.018980000004, + "iscrowd": 0, + "segmentation": [], + "text": "Pharmacokinetic Modeling for Optimization of Opioid Dosing Regimens" + }, + { + "id": 46800, + "strid": "c1d8fba5-6015-454e-aeba-ee6a6e907226", + "image_id": 202331, + "image_name": "118558.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 562.833, + 238.899, + 2812.075, + 252.933 + ], + "priority": 2, + "parents": [ + 46824 + ], + "children": [], + "area": 134460.240867, + "iscrowd": 0, + "segmentation": [], + "text": "Oscar Linares MD?, David Daly-JD/MBA2, Darko StefanovskiPhD?, Raymond Boston PhD*\n\nPlymouth Pharmacokinetic Modeling Study Group??, Plymouth, MI; BiomedicahSciences?, Cedars-Sinai Medical Center, Hollywood,\nCA; Dept. of Epidemiologyrand Biostatistics*, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA." + }, + { + "id": 46801, + "strid": "117f46d8-4fc8-4fb6-9379-345a1a69ef62", + "image_id": 202331, + "image_name": "118558.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 551.821, + 647.32, + 278.52599999999995, + 40.17399999999998 + ], + "priority": 3, + "parents": [ + 46824 + ], + "children": [ + 46811 + ], + "area": 357204.76972000004, + "iscrowd": 0, + "segmentation": [], + "text": "INTRODUCTION" + }, + { + "id": 46811, + "strid": "0dbe5b89-184d-4771-89c7-cf011bef59dc", + "image_id": 202331, + "image_name": "118558.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 100.013, + 722.859, + 1163.447, + 579.755 + ], + "priority": 4, + "parents": [ + 46801 + ], + "children": [], + "area": 72295.29716700001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 46802, + "strid": "827ca887-6570-4c7d-a6e8-f2869f3f5a51", + "image_id": 202331, + "image_name": "118558.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 610.144, + 1319.434, + 167.77199999999993, + 40.77099999999996 + ], + "priority": 5, + "parents": [ + 46824 + ], + "children": [ + 46812 + ], + "area": 805044.738496, + "iscrowd": 0, + "segmentation": [], + "text": "PURPOSE" + }, + { + "id": 46812, + "strid": "9886036d-119b-4a8b-a42d-dd506f158e04", + "image_id": 202331, + "image_name": "118558.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 101.577, + 1374.106, + 1077.534, + 108.94100000000003 + ], + "priority": 6, + "parents": [ + 46802 + ], + "children": [], + "area": 139577.56516199998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 46823, + "strid": "7ed57d7c-2b8a-485a-96b5-e99c1ca95baf", + "image_id": 202331, + "image_name": "118558.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 505.335, + 1514.096, + 375.171, + 41.17399999999998 + ], + "priority": 7, + "parents": [ + 46824 + ], + "children": [ + 46814, + 46813, + 46815 + ], + "area": 765125.70216, + "iscrowd": 0, + "segmentation": [], + "text": "Method of Procedure" + }, + { + "id": 46813, + "strid": "64c2d6f7-a631-4973-ba11-cb1c10d3c50d", + "image_id": 202331, + "image_name": "118558.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 107.753, + 1577.746, + 1105.108, + 109.0440000000001 + ], + "priority": 8, + "parents": [ + 46823 + ], + "children": [], + "area": 170006.864738, + "iscrowd": 0, + "segmentation": [], + "text": "Step 1: Identify morphine's ’s MSC, MEC and basic population pharmacokinetic\nparameter values.\n\nMorphine’s basic population pharmacokinetic parameter values? are :" + }, + { + "id": 46814, + "strid": "a4190217-9a19-46fe-84e0-295eb09340d4", + "image_id": 202331, + "image_name": "118558.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 461.602, + 1707.45, + 460.28, + 175.039 + ], + "priority": 9, + "parents": [ + 46823 + ], + "children": [], + "area": 788162.3349, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 46815, + "strid": "18028614-d6f7-46bf-b9a3-f1ac2f817cdb", + "image_id": 202331, + "image_name": "118558.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 106.036, + 1906.989, + 1171.259, + 1445.4320000000002 + ], + "priority": 10, + "parents": [ + 46823 + ], + "children": [], + "area": 202209.48560400002, + "iscrowd": 0, + "segmentation": [], + "text": "where T1/2 is elimination half-life, ke is first-order elimination rate constant, Vd is apparent\nvolume of distribution, Cl is clearance rate and F is bioavailability.\n\nMorphine’s therapeutic range is 10 to 80 g/L in surgical patients*. In cancer patients, its\nanalgesic plasma levels are > 20 pg/L? .\n\nStep 2: Determine Target Therapeutic Concentration (TTC). The next task is to\ndetermine the TTC of MS for the patient. The formula for an “average” TTC is:\n\n_ MSC —MEC\n(Gag -oos Se L 1\ntarget MSC (ug/ ) ( )\nLn} ——\nMEC\n\nStep 3: Determine Dose Rate (Dpat-). Once the clinician chooses a TTC, the clinician can\nuse clinical pharmacokinetics to calculate the dose rate required to achieve the TTC.\n\n_ TTC (ug/L) xCl (Lih/kg) x Weight (kg)\nF\n\n \n\nD 0.001 (mg/h) (2)\n\nRate\n\nStep 4: Determine the Maintenance Dose (Dy): The physician choses a dosing interval,\nt, then:\n\nDy = Dare * 7(mg) (3)\n\nStep 5: Use Pharmacokinetic Modeling to Design the Dosing Regimen: This is\nperformed using the equations below. The R package cpk automates the use of these\nequations:\n\n \n\nC= FxD aR\nd\n\nC, — Dawe * F Yap (4)\nCl\n\nCain = Coax x Ba?\nC(t) =C,,,. x e*" + }, + { + "id": 46809, + "strid": "4a8c492c-1538-41b0-9f49-68fb985d505b", + "image_id": 202331, + "image_name": "118558.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 454.043, + 3397.146, + 478.932, + 40.1869999999999 + ], + "priority": 11, + "parents": [ + 46824 + ], + "children": [ + 46810 + ], + "area": 1542450.361278, + "iscrowd": 0, + "segmentation": [], + "text": "MATERIALS AND METHODS" + }, + { + "id": 46810, + "strid": "aba4d9ce-6aad-45f0-a952-e06f26ed18f4", + "image_id": 202331, + "image_name": "118558.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 132.414, + 3472.367, + 1111.139, + 172.4630000000002 + ], + "priority": 12, + "parents": [ + 46809 + ], + "children": [], + "area": 459790.003938, + "iscrowd": 0, + "segmentation": [], + "text": "An 87 kg man with severe pain caused by prostate cancer metastasized to the lumbar\nspine is hospitalized to receive IV morphine. The standard weight-based morphine\ndosing guideline provides for a dose of 0.5, 1.0 or 1.5 mg/kg IV every 4 hours, which\ncorresponds to 10, 20 or 30 mg morphine every 4 h. Clinical pharmacokinetics were\ncomputed with MSC = 80 ug/L and MEC = 10 and 20 ug/L." + }, + { + "id": 46803, + "strid": "45c17fd0-40df-4713-b151-479024d93e21", + "image_id": 202331, + "image_name": "118558.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1892.528, + 647.262, + 152.28700000000003, + 41.63599999999997 + ], + "priority": 13, + "parents": [ + 46824 + ], + "children": [ + 46822, + 46819, + 46821, + 46808, + 46820 + ], + "area": 1224961.4583359999, + "iscrowd": 0, + "segmentation": [], + "text": "RESULTS" + }, + { + "id": 46819, + "strid": "ec1134a5-8fbf-4115-a0c3-7abb54b19528", + "image_id": 202331, + "image_name": "118558.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1364.292, + 814.972, + 1161.846, + 527.02 + ], + "priority": 14, + "parents": [ + 46803 + ], + "children": [ + 46818 + ], + "area": 1111859.7798239999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 46818, + "strid": "db3e8fc5-6082-4d1e-b3df-244bb7021194", + "image_id": 202331, + "image_name": "118558.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1410.389, + 723.41, + 1140.9200000000003, + 66.22400000000005 + ], + "priority": 15, + "parents": [ + 46819 + ], + "children": [], + "area": 1020289.5064899998, + "iscrowd": 0, + "segmentation": [], + "text": "Figures 1-4 show predicted plasma morphine concentration time courses for IV\nmorphine boluses repeated every 4 hours using 10 mg, 17 mg, 20 mg and 30 mg doses." + }, + { + "id": 46820, + "strid": "14329e6e-dc0c-49c6-86df-377206460e46", + "image_id": 202331, + "image_name": "118558.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1369.138, + 1380.634, + 1186.5820000000003, + 542.9079999999999 + ], + "priority": 16, + "parents": [ + 46803 + ], + "children": [], + "area": 1890278.473492, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 46821, + "strid": "f278895f-adb0-49e1-8093-5bfe3e8abb91", + "image_id": 202331, + "image_name": "118558.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1371.854, + 1955.992, + 1184.979, + 542.9109999999998 + ], + "priority": 17, + "parents": [ + 46803 + ], + "children": [], + "area": 2683335.449168, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 46822, + "strid": "5c89224c-1b92-4b50-9954-3eda5fe03088", + "image_id": 202331, + "image_name": "118558.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1369.031, + 2530.092, + 1188.145, + 544.3339999999998 + ], + "priority": 18, + "parents": [ + 46803 + ], + "children": [], + "area": 3463774.380852, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 46808, + "strid": "7fecba0c-30a7-4abf-a73a-be4c42b099f1", + "image_id": 202331, + "image_name": "118558.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1380.668, + 3175.129, + 1176.593, + 423.1170000000002 + ], + "priority": 19, + "parents": [ + 46803 + ], + "children": [], + "area": 4383799.0061719995, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 46804, + "strid": "2f364dea-b0b9-419b-88de-a15b617ded74", + "image_id": 202331, + "image_name": "118558.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3136.029, + 646.593, + 219.08399999999983, + 40.97900000000004 + ], + "priority": 20, + "parents": [ + 46824 + ], + "children": [ + 46816 + ], + "area": 2027734.3991969998, + "iscrowd": 0, + "segmentation": [], + "text": "DISCUSSION" + }, + { + "id": 46816, + "strid": "81cb0bbc-6899-49f9-b1d7-7f12ac94f4b0", + "image_id": 202331, + "image_name": "118558.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2667.275, + 725.504, + 1166.62, + 564.649 + ], + "priority": 21, + "parents": [ + 46804 + ], + "children": [], + "area": 1935118.6816, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1 shows that, if the cancer patient receives morphine 10 mg IV every 4 hours, then\nthe patient's plasma morphine concentration falls below the MEC for 2.2 hours of each 4\nhour dosing interval. Pain control is inadequate.\n\nFigure 2 shows that, if the patient receives morphine 17 mg IV every 4 hours, then the\npatient’s plasma morphine concentration falls below the MEC for 0.6 hours of each 4 hour\ndosing interval. Pain control is better, but not optimal.\n\nFigure 3 shows that, if the patient receives morphine 20:mg!V every 4 hours, then the\npatient’s plasma morphine concentration never falls below the MEC nor exceeds the MSC\nduring each 4 hour dosing interval. Pain control is optimal.\n\nFigure 4 shows that, if the patient receives morphine 30 mg IV every 4 hours, then the\npatient’s plasma morphine concentration always exceeds the MEC during each 4 hour\ndosing interval, but repeatedly exceeds the MSC. This dose is toxic for this patient." + }, + { + "id": 46805, + "strid": "09fcc6e5-24af-4ccf-b8a6-97075bedaadc", + "image_id": 202331, + "image_name": "118558.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3118.874, + 1430.342, + 253.37699999999995, + 38.855999999999995 + ], + "priority": 22, + "parents": [ + 46824 + ], + "children": [ + 46817 + ], + "area": 4461056.474908, + "iscrowd": 0, + "segmentation": [], + "text": "CONCLUSIONS" + }, + { + "id": 46817, + "strid": "606ce77d-5c10-46c9-ad6e-9f2642f1adc5", + "image_id": 202331, + "image_name": "118558.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2674.211, + 1513.976, + 1114.38, + 257.278 + ], + "priority": 23, + "parents": [ + 46805 + ], + "children": [], + "area": 4048691.272936, + "iscrowd": 0, + "segmentation": [], + "text": "Clinical pharmacokinetics helps a clinician to design a morphine dosing regimen that\nkeeps the patient’s plasma morphine concentration within the therapeutic range for\nthe entire dosing interval. This helps achieve optimal pain control while avoiding\n\ntoxicity. This same approach can be used to optimize dosing for other opioid pain\nmedicines.\n\nR package cpk is available on the Comprehensive R Archive Network (CRAN)" + }, + { + "id": 46806, + "strid": "6735187b-97e8-48c0-a2be-86f712eaca66", + "image_id": 202331, + "image_name": "118558.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3135.722, + 2962.207, + 220.55000000000018, + 39.735999999999876 + ], + "priority": 24, + "parents": [ + 46824 + ], + "children": [ + 46807 + ], + "area": 9288657.658454001, + "iscrowd": 0, + "segmentation": [], + "text": "REFERENCES" + }, + { + "id": 46807, + "strid": "35084ca9-49ef-44a6-b1e5-0ac3e4e4e535", + "image_id": 202331, + "image_name": "118558.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2653.888, + 3038.225, + 1183.98, + 407.299 + ], + "priority": 25, + "parents": [ + 46806 + ], + "children": [], + "area": 8063108.868799999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 42944, + "strid": "9fc3b1e8-274a-45b1-bc90-7b1863738b53", + "image_id": 202180, + "image_name": "118291.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 727.47, + 20.28, + 73.53999999999996, + 73.53999999999999 + ], + "priority": -1, + "parents": [], + "children": [ + 42929, + 42928, + 42931, + 42935, + 42927, + 42930 + ], + "area": 14753.091600000002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 42927, + "strid": "9c213268-cdfd-4228-a048-d4866405cb40", + "image_id": 202180, + "image_name": "118291.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 48.705, + 44.763, + 663.144, + 158.035 + ], + "priority": 1, + "parents": [ + 42944 + ], + "children": [], + "area": 2180.1819149999997, + "iscrowd": 0, + "segmentation": [], + "text": "Efficacy of fentanyl pectin nasal\nspray in elderly patients with\nnon-cancer breakthrough pain" + }, + { + "id": 42928, + "strid": "ddff76ea-7a9f-46a6-b1bf-3b7c3f013191", + "image_id": 202180, + "image_name": "118291.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 577.69, + 215.838, + 199.85000000000002, + 63.859999999999985 + ], + "priority": 2, + "parents": [ + 42944 + ], + "children": [], + "area": 124687.45422000001, + "iscrowd": 0, + "segmentation": [], + "text": "Dr. Rafael Salazar-Vecino\nHospital Comarcal de Inca\nBalearic Islands (Spain)" + }, + { + "id": 42929, + "strid": "35424a4b-8dab-44e1-9927-33a46d21a917", + "image_id": 202180, + "image_name": "118291.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 50.271, + 215.662, + 116.996, + 19.899 + ], + "priority": 3, + "parents": [ + 42944 + ], + "children": [ + 42932 + ], + "area": 10841.544402000001, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 42932, + "strid": "2706e2d5-1dd4-4b10-91b0-05abf47b6f77", + "image_id": 202180, + "image_name": "118291.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 48.934, + 248.333, + 343.332, + 137.689 + ], + "priority": 4, + "parents": [ + 42929 + ], + "children": [], + "area": 12151.927022, + "iscrowd": 0, + "segmentation": [], + "text": "Breakthrough pain in non-cancer patients has the\nsame characteristics as pain in neoplastic cases, with a\nprevalence of 60-75%, 2-4 episodes a day, and a duration\nof between 30 minutes to two hours. The pain may be of\nsomatic, neuropathic or mixed presentation — incidental\npain in relation to motor activity being the most common\nform, and thus the most predictable presentation —" + }, + { + "id": 42930, + "strid": "3bcfa43b-376f-4991-80b3-954a03eb2119", + "image_id": 202180, + "image_name": "118291.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 48.757, + 401.43, + 210.998, + 20.896000000000015 + ], + "priority": 5, + "parents": [ + 42944 + ], + "children": [ + 42933 + ], + "area": 19572.52251, + "iscrowd": 0, + "segmentation": [], + "text": "Material and methods" + }, + { + "id": 42933, + "strid": "eeec6d03-ff7e-457f-8a48-12e33f09d8f0", + "image_id": 202180, + "image_name": "118291.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 48.508, + 434.853, + 343.63, + 413.17699999999996 + ], + "priority": 6, + "parents": [ + 42930 + ], + "children": [], + "area": 21093.849324000003, + "iscrowd": 0, + "segmentation": [], + "text": "A6-week evaluation was made of 22 patients, of which 20\ncompleted the study (18 females, 2 males; 60-88 years of\nage, mean age 74.7 years). The following diagnoses were\nestablished (of which each patient may have presented\nmore than one): vertebral collapse or fracture (n=8), canal\nstenosis (1=7), gonarthrosis (n=6), disc hernia (n=4), disc\nspondyloarthrosis (n=4), sequelae of arthrodesis (n=3),\npostsurgery of total knee prosthesis (n=1),\n\nResting pain controlled with oxycodone / naloxone\nbetween 5/2.5 and 60/30 mg/day (n=14), tapentadol\n100-200 mg/day (n=2), fentanyl TTS 25-75 mg (n=2) and\nhydromorphone 8-16 mg (n=2), in addition to other drugs,\nwere not modified during the study, in order to evaluate the\nefficacy of fentanyl pectin nasal spray.\n\nTo this effect, the following was measured: Pain visual\nanalog scale (VAS) at rest and in movement, after 0, 2,\n4 and 6 weeks; SF-12 and EuroQoL (EQ-5D) scales;\nEuropean health scale; Oswestry functional test; and MOS\nsleep disturbances score, after 0, 4 and 6 weeks. Lastly\nPatient global impression of change (PGIC) was also rated." + }, + { + "id": 42931, + "strid": "c6d9003f-0689-4652-af8f-f883a2657e94", + "image_id": 202180, + "image_name": "118291.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 49.233, + 863.492, + 260.28, + 20.630999999999972 + ], + "priority": 7, + "parents": [ + 42944 + ], + "children": [ + 42934 + ], + "area": 42512.301636, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions and comment:" + }, + { + "id": 42934, + "strid": "d3047055-e7cf-43a5-91f7-1ce8fd13d4f9", + "image_id": 202180, + "image_name": "118291.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 48.477, + 896.495, + 344.309, + 223.6060000000001 + ], + "priority": 8, + "parents": [ + 42931 + ], + "children": [], + "area": 43459.388114999994, + "iscrowd": 0, + "segmentation": [], + "text": "Despite the delicate health condition of the patients in\nthe study, of which they are well aware, and their limited\ndaily living activities, fentanyl pectin nasal spray afforded\nimportant breakthrough pain relief. This improved their\nquality of life, allowing a degree of mobilty, with improved\nself-care, and the possiblity to perform simple domestic\nchores and leisure activities. In addition, those who had\ndifficulties falling asleep at night because of the pain\nreported improved sleep quality. In sum, global recovery of\nroutine life was achieved\n\nEFIC Congress, Florence, Italy, October 9-12, 2013, ABSTRACT #414" + }, + { + "id": 42935, + "strid": "60d34b1b-bca0-4359-a07d-acd35b6f4fed", + "image_id": 202180, + "image_name": "118291.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 425.11, + 401.709, + 77.25999999999999, + 22.261000000000024 + ], + "priority": 9, + "parents": [ + 42944 + ], + "children": [ + 42936, + 42937, + 42940, + 42941, + 42939, + 42938, + 42942, + 42943 + ], + "area": 170770.51299000002, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 42936, + "strid": "1f62fbaa-d91a-4c79-bd6d-02287da8bf41", + "image_id": 202180, + "image_name": "118291.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 426.528, + 471.973, + 160.39999999999998, + 126.70700000000005 + ], + "priority": 10, + "parents": [ + 42935 + ], + "children": [], + "area": 201309.699744, + "iscrowd": 0, + "segmentation": [] + }, + { + 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Yujuan Fu', Scott Jones*, Joerg Waldhaus?, Jie Liu’\n‘Department of Computational Medicine and Bioinformatics, 7Department of Otolaryngology-Head and Neck\nSurgey, Medical School, University of Michigan, Ann Arbor, MI." + }, + { + "id": 141201, + "strid": "d493c909-a726-4f44-abd1-f74ad7538e10", + "image_id": 205988, + "image_name": "16876.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 150.677, + 662.663, + 441.404, + 69.88900000000001 + ], + "priority": 3, + "parents": [ + 141227 + ], + "children": [ + 141205 + ], + "area": 99848.07285099999, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 141205, + "strid": "2a651ba2-5add-4e5e-a14e-e1b8c51beaa0", + "image_id": 205988, + "image_name": "16876.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 156.123, + 766.966, + 1438.176, + 852.2130000000001 + ], + "priority": 4, + "parents": [ + 141201 + ], + "children": [], + "area": 119741.03281799999, + "iscrowd": 0, + "segmentation": [] + 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Identification of organ of Corti cell types. (A) Expression heatmap of differentially expressed genes\nat single-cell resolution. (B) Accessibility heatmap of Annotated differentially accessible regions at single-cell\nresolution. 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Currently sho i\n\n \n\n \n\n \n\nunable to walk: Deep tendon rfleses are ves in upper and fs in ever Kms\nBulbar muscles are spared and no fet mor neuron physical signs are present\nWhevas MEP sty shows subelinisal impaizment of motor ce\nlly reduced (\\1C 78%). The ALS\n\nve involyghento¢ laboratory and radiological evidence of Pag.\n\nal pathy in al\n\n \n\n \n\nPRS sor a\n\n \n\nins. Respiratory fation i\n\n \n\n27/8. No cognit\n\n \n\ndiseave are detected, Anammestic and objective dats are suggestive of PMA\nphenotype with yey slow course\n\nHer mother indvidnal II-1) at 31 years of age doveloped slow couse MND with\nsinal cnet an Inte bulbar signs. She dil stage $3 besa of respiratory file.\nAanetic data revealed th\n\nqutosomal dominant inheritance (ifividuals ILI, III? e IV-4). Notbly. the\n\n \n\n2 Ukely affected relatives with evidence of an\n\nproband’ cousin (IV\"4 showed spinal emiet MIND with a disease duration of ten\nyears Based on reported anamnestic dts none of affect meters suffered fiom\ndementia\n\nNoa\n\n \n\ntations were found in SPD/, COORF72, TDP-43, FUS and ANG genes i\n\nthe proband. Molacula aalsss showed a heterozygous mutation © 453C>T i the\n\n \n\nPCP gene (codon 155 in exon 8) determining a substitution of arginine to eysteine\nin the VCP protia (pRISSC). No DNA was available Geum the other atfeted\n\napi," + }, + { + "id": 53217, + "strid": "8f7441ab-75b4-453d-8285-d218989dc1bc", + "image_id": 202591, + "image_name": "118918.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 416.608, + 219.7, + 372.16800000000006, + 182.34999999999997 + ], + "priority": 6, + "parents": [ + 53228 + ], + "children": [], + "area": 91528.7776, + "iscrowd": 0, + "segmentation": [], + "text": "SNe eee a dee a Raa ce\ncemosome 99133.\ncharacterized by Inclusion body Myopatby With Paget disease and Fromtotempeal\nDementia (BMPFD) (1), Motations ia the TCP gene have hoea sescally posted aa\n\ncane of 1\n\n \n\np12, were identified asthe genetic ease of an unusual syndrome\n\n \n\n2% of familial amyonophic lateral sclerosis (ALS) cases (2) To date. 4\nVP nmtations have besa reported. Among these, 1 missense mutations have been\nling five detest in both ISMPED and ALS ani five in\nonly ALS eases, Hege We report the p.RISSC mutation ia the [CP gine in aa Italian\n\n \n\npatent with laser motor neuron signs and autosomal dominaut history of mtor\n\nas" + }, + { + "id": 53225, + "strid": "68e01efd-cc96-4b9d-8bfa-9213917ddcdd", + "image_id": 202591, + "image_name": "118918.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 494.391, + 403.911, + 216.551, + 153.488 + ], + "priority": 7, + "parents": [ + 53228 + ], + "children": [ + 53223 + ], + "area": 199689.963201, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 53223, + "strid": "0191795c-aac9-4ca6-9ac7-92344b74bf89", + "image_id": 202591, + "image_name": "118918.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 520.331, + 565.303, + 149.39999999999998, + 7.788000000000011 + ], + "priority": 8, + "parents": [ + 53225 + ], + "children": [], + "area": 294144.675293, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 53219, + "strid": "6dbd415a-931a-45d5-9c16-037bfe748c7d", + "image_id": 202591, + "image_name": "118918.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 413.602, + 586.421, + 378.6170000000001, + 70.02200000000005 + ], + "priority": 9, + "parents": [ + 53228 + ], + "children": [], + "area": 242544.898442, + "iscrowd": 0, + "segmentation": [], + "text": "METHODS: ADS)diagnosis was made accordingly to ET ExcdnfaD Revisited craceia,\nAfter obtotig writen consensus, DNA was extract fio peripheral blood. AM the\n17 coding exons of UCP gene were analyzed ting PCR and sequencing. Gunes\nanaes was also performed far SOD!. C9ORF72, TOPS3. FUS and ANG genca." + }, + { + "id": 53227, + "strid": "f9133d47-6db7-4f66-b431-731bdec928d5", + "image_id": 202591, + "image_name": "118918.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 435.447, + 671.354, + 333.967, + 195.856 + ], + "priority": 10, + "parents": [ + 53228 + ], + "children": [ + 53222 + ], + "area": 292339.085238, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 53222, + "strid": "0fdeca51-9416-4207-bdd2-067ed3b30992", + "image_id": 202591, + "image_name": "118918.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 439.614, + 874.173, + 326.522, + 19.31899999999996 + ], + "priority": 11, + "parents": [ + 53227 + ], + "children": [], + "area": 384298.68922199996, + "iscrowd": 0, + "segmentation": [], + "text": "een ere te aa\nra, canting fechas remviry porate arena ~~ Ac" + }, + { + "id": 53220, + "strid": "43836b7e-1371-47ea-8351-15ceb9cf81ea", + "image_id": 202591, + "image_name": "118918.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 414.549, + 910.584, + 376.42599999999993, + 184.16700000000003 + ], + "priority": 12, + "parents": [ + 53228 + ], + "children": [], + "area": 377481.68661599996, + "iscrowd": 0, + "segmentation": [], + "text": "ce Cee TT da a a\npatient belonging 0 2 family with autosomal dominant transmission ND. The\n\nmutation is known to be pathogenetic. Arginine SS in exon $ is the most common\n\n \n\natational hotspot and the pRR1SSC isthe mest flequont mutation found in BMIPFD\npedigrees. To dite, this mitation has been previously found in only one AES family in\nwhich debiled clinical infomnation is act availble (3). Phinotypic variability\n\nassociated with CP mt\n\n \n\nious has been reported between sl within families with\n\n \n\nTD, IBM (inclusion Body Myopathy), PDB (Paget disease): ALS ora combination of\nthee diseases, Ourdala extend the range of phenotype sociated with \"CP mutations\n\nSe iecincs palinrls yal hlawiv' peceseninve loved tietar menran diaeaae}" + }, + { + "id": 53221, + "strid": "4bcb1e6b-9c36-4ebc-b7f8-b21c8586950b", + "image_id": 202591, + "image_name": "118918.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 28.133, + 1013.408, + 363.315, + 77.59900000000005 + ], + "priority": 13, + "parents": [ + 53228 + ], + "children": [], + "area": 28510.207264, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 66615, + "strid": "d8448226-7709-4012-8cb6-7bb9e93586c7", + "image_id": 203114, + "image_name": "119736.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 41.99, + 35.08, + 383.5, + 105.07000000000001 + ], + "priority": -1, + "parents": [], + "children": [ + 66608, + 66606, + 66607, + 66605 + ], + "area": 1473.0092, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 66605, + "strid": "8be768fe-faf4-49db-bf63-5fba1062113d", + "image_id": 203114, + "image_name": "119736.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 186.163, + 168.81, + 5238.698999999999, + 143.77500000000003 + ], + "priority": 1, + "parents": [ + 66615 + ], + "children": [], + "area": 31426.176030000002, + "iscrowd": 0, + "segmentation": [], + "text": "Direction specific signals for saccadic eye movements: Effect of traumatic brain injury" + }, + { + "id": 66606, + "strid": "1cae1a95-b917-4268-939d-10f7b3e0ea51", + "image_id": 203114, + "image_name": "119736.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 374.944, + 459.099, + 4868.854, + 98.56699999999995 + ], + "priority": 2, + "parents": [ + 66615 + ], + "children": [], + "area": 172136.41545600002, + "iscrowd": 0, + "segmentation": [], + "text": "Christopher W. Tyler., Lora T. Likova and Spero C. Nicholas, Smith-Kettlewell Eye Research Institute, San Francisco" + }, + { + "id": 66607, + "strid": "09133189-5740-4006-a47d-911536440ffd", + "image_id": 203114, + "image_name": "119736.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 540.797, + 728.119, + 813.027, + 114.70100000000002 + ], + "priority": 3, + "parents": [ + 66615 + ], + "children": [ + 66609 + ], + "area": 393764.570843, + "iscrowd": 0, + "segmentation": [], + "text": "Previous Study" + }, + { + "id": 66609, + "strid": "5d7b1ce9-eb02-4f0b-b3fa-09603a6556cd", + "image_id": 203114, + "image_name": "119736.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 90.937, + 926.974, + 1701.09, + 1048.06 + ], + "priority": 4, + "parents": [ + 66607 + ], + "children": [], + "area": 84296.23463800001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 66608, + "strid": "627c1114-de15-4075-9dbb-8a464d48eb42", + "image_id": 203114, + "image_name": "119736.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 369.965, + 2131.274, + 1122.109, + 122.65999999999985 + ], + "priority": 5, + "parents": [ + 66615 + ], + "children": [ + 66614, + 66613, + 66612, + 66611, + 66610 + ], + "area": 788496.7854099999, + "iscrowd": 0, + "segmentation": [], + "text": "Directional Paradigm" + }, + { + "id": 66610, + "strid": "1abc443a-7514-4a98-997b-2682e13dd90d", + "image_id": 203114, + "image_name": "119736.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 82.965, + 2327.95, + 1708.09, + 1098.1109999999999 + ], + "priority": 6, + "parents": [ + 66608 + ], + "children": [], + "area": 193138.37175, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 66611, + "strid": "8e76af9e-a053-401b-b6d5-98bdfa7a3820", + "image_id": 203114, + "image_name": "119736.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1859.962, + 666.979, + 1725.1039999999998, + 1308.069 + ], + "priority": 7, + "parents": [ + 66608 + ], + "children": [], + "area": 1240555.594798, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 66614, + "strid": "c23b4d59-d2c5-44df-812c-ec846c9925b3", + "image_id": 203114, + "image_name": "119736.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1901.658, + 2115.88, + 1634.8849999999998, + 1259.781 + ], + "priority": 8, + "parents": [ + 66608 + ], + "children": [], + "area": 4023680.12904, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 66612, + "strid": "bbc5585c-1e7d-4dce-8dd9-87ec75da35db", + "image_id": 203114, + "image_name": "119736.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3693.619, + 725.563, + 1726.4059999999995, + 1130.4809999999998 + ], + "priority": 9, + "parents": [ + 66608 + ], + "children": [], + "area": 2679953.282497, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 66613, + "strid": "94395d02-70eb-4840-935d-4f3c47192396", + "image_id": 203114, + "image_name": "119736.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3703.446, + 2142.662, + 1729.6220000000003, + 1167.946 + ], + "priority": 10, + "parents": [ + 66608 + ], + "children": [], + "area": 7935233.013251999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 163967, + "strid": "4a7badf8-b65c-4f1f-b6bd-33d39df683cd", + "image_id": 206897, + "image_name": "6606.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 135.15, + 163.36, + -135.15, + -163.36 + ], + "priority": -1, + "parents": [], + "children": [ + 163948, + 163962, + 163952, + 163951, + 163953, + 163950, + 163949 + ], + "area": 22078.104000000003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 163948, + "strid": "dc40bc1c-98d7-4e3c-a794-212064793e95", + "image_id": 206897, + "image_name": "6606.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 571.919, + 119.458, + 2150.147, + 158.79299999999998 + ], + "priority": 1, + "parents": [ + 163967 + ], + "children": [], + "area": 68320.299902, + "iscrowd": 0, + "segmentation": [], + "text": "The influence of the phase of the beta rhythm on EEG-BOLD coupling:\na simultaneous intracranial EEG-fMRI study in humans" + }, + { + "id": 163949, + "strid": "4b9e31d5-e598-46b3-905b-d52050df4dbf", + "image_id": 206897, + "image_name": "6606.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 534.624, + 324.409, + 2242.991, + 196.375 + ], + "priority": 2, + "parents": [ + 163967 + ], + "children": [], + "area": 173436.837216, + "iscrowd": 0, + "segmentation": [], + "text": "T. MURTA™2, U. J. CHAUDHARY’, D. W. CARMICHAEL, P. FIGUEIREDO?, L. LEMIEUX\"\n\n'Dept. of Clinical and Experimental Epilepsy, Institute of Neurology, London, UK; pn\n*Dept. of Bioengineering, Institute for Systems and Robotics, Lisbon, Portugal; 93UCL Institute of Child Health, London, UK" + }, + { + "id": 163950, + "strid": "532c5e95-e71b-446d-9831-a1bd760352a6", + "image_id": 206897, + "image_name": "6606.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 117.096, + 710.73, + 319.673, + 56.980999999999995 + ], + "priority": 3, + "parents": [ + 163967 + ], + "children": [ + 163954 + ], + "area": 83223.64008000001, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 163954, + "strid": "83252648-970f-4eeb-a1c8-80f5732a89fe", + "image_id": 206897, + "image_name": "6606.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 106.311, + 796.478, + 1475.096, + 720.3959999999998 + ], + "priority": 4, + "parents": [ + 163950 + ], + "children": [], + "area": 84674.37265800001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 163951, + "strid": "56aed6b6-077e-4212-aece-8c034d755418", + "image_id": 206897, + "image_name": "6606.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 110.669, + 1602.993, + 232.83800000000002, + 51.89799999999991 + ], + "priority": 5, + "parents": [ + 163967 + ], + "children": [ + 163963, + 163955, + 163966, + 163960, + 163956, + 163958 + ], + "area": 177401.63231699998, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 163958, + "strid": "ac39d393-94cf-4bd9-8547-374a9929212a", + "image_id": 206897, + "image_name": "6606.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 163.26, + 1738.691, + 1351.773, + 63.182000000000016 + ], + "priority": 6, + "parents": [ + 163951 + ], + "children": [], + "area": 283858.69266, + "iscrowd": 0, + "segmentation": [], + "text": "Relationship between the icEEG power and the BOLD signal" + }, + { + "id": 163966, + "strid": "db1ee0d2-e58f-45e6-b18a-f118adaa5f36", + "image_id": 206897, + "image_name": "6606.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 91.992, + 1845.523, + 1516.209, + 1157.93 + ], + "priority": 7, + "parents": [ + 163951 + ], + "children": [], + "area": 169773.351816, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 163960, + "strid": "df55f904-7896-4220-9abe-63da1118cc3f", + "image_id": 206897, + "image_name": "6606.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 143.746, + 3121.416, + 1403.109, + 122.64199999999983 + ], + "priority": 8, + "parents": [ + 163951 + ], + "children": [], + "area": 448691.06433600007, + "iscrowd": 0, + "segmentation": [], + "text": "Influence of the phase of beta on the relationship between the\nicEEG power and the BOLD signal" + }, + { + "id": 163963, + "strid": "f8035c7f-889f-4c45-9adb-58f2d36af416", + "image_id": 206897, + "image_name": "6606.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 85.417, + 3306.727, + 1523.021, + 983.2860000000001 + ], + "priority": 9, + "parents": [ + 163951 + ], + "children": [], + "area": 282450.700159, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 163956, + "strid": "5c7967e2-83fe-4030-a545-a35f4e735f87", + "image_id": 206897, + "image_name": "6606.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1745.925, + 770.032, + 1446.316, + 124.024 + ], + "priority": 10, + "parents": [ + 163951 + ], + "children": [], + "area": 1344418.1196, + "iscrowd": 0, + "segmentation": [], + "text": "Relationship between the phase—amplitude coupling and the\nBOLD signal" + }, + { + "id": 163955, + "strid": "00a03a6e-ca29-4a48-a54e-cd8d82260d75", + "image_id": 206897, + "image_name": "6606.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1715.396, + 966.563, + 1486.385, + 425.4989999999999 + ], + "priority": 11, + "parents": [ + 163951 + ], + "children": [], + "area": 1658038.3039479998, + "iscrowd": 0, + "segmentation": [], + "text": "Phase-amplitude coupling (PAC): the amplitude of high-frequency\nicEEG components is coupled with the phase of the low-frequency\nones.\n\n* We investigate how the strength of PAC between beta and various\nhigh-frequency icEEG components is correlated with the BOLD\nsignal. PAC was quantified through the Modulation Index (Tort et al.\nPNAS 2008)." + }, + { + "id": 163952, + "strid": "862da6a0-9bc3-41b9-9ad2-224e1963e74e", + "image_id": 206897, + "image_name": "6606.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1742.46, + 1575.634, + 195.09500000000003, + 50.2650000000001 + ], + "priority": 12, + "parents": [ + 163967 + ], + "children": [ + 163964, + 163965, + 163959, + 163957 + ], + "area": 2745479.2196400003, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 163957, + "strid": "775b5941-f47f-41ff-9f28-9883e4ca78ba", + "image_id": 206897, + "image_name": "6606.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1730.454, + 1713.366, + 1473.7769999999998, + 115.89300000000003 + ], + "priority": 13, + "parents": [ + 163952 + ], + "children": [], + "area": 2964901.048164, + "iscrowd": 0, + "segmentation": [], + "text": "Correlation between regional BOLD signal (M1 area) and the icEEG power\nas function of icEEG frequency:" + }, + { + "id": 163965, + "strid": "4a1535e1-8154-48be-963a-cf14082ac360", + "image_id": 206897, + "image_name": "6606.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1734.318, + 1848.578, + 1452.059, + 689.5619999999999 + ], + "priority": 14, + "parents": [ + 163952 + ], + "children": [], + "area": 3206022.099804, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 163959, + "strid": "adf7b029-a0bc-4fd4-a4a2-7de9ff6f7ae3", + "image_id": 206897, + "image_name": "6606.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1730.655, + 2697.883, + 1473.0290000000002, + 103.49200000000019 + ], + "priority": 15, + "parents": [ + 163952 + ], + "children": [], + "area": 4669104.703365, + "iscrowd": 0, + "segmentation": [], + "text": "Correlation between regional BOLD signal (M1 area) and the PAC between\nthe phase of 20Hz and the amplitude at different icEEG frequencies:" + }, + { + "id": 163964, + "strid": "6e41b4b8-d898-4608-8a70-d6773ae01125", + "image_id": 206897, + "image_name": "6606.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1735.338, + 2824.775, + 1447.5889999999997, + 684.799 + ], + "priority": 16, + "parents": [ + 163952 + ], + "children": [], + "area": 4901939.39895, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 163953, + "strid": "1007c534-248e-4293-b40a-72fd3f7c816f", + "image_id": 206897, + "image_name": "6606.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1737.753, + 3698.589, + 305.1189999999999, + 62.07600000000002 + ], + "priority": 17, + "parents": [ + 163967 + ], + "children": [ + 163961 + ], + "area": 6427234.130516999, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion" + }, + { + "id": 163961, + "strid": "fbcfb0ec-5a70-4003-b9a9-375043e898bf", + "image_id": 206897, + "image_name": "6606.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1727.833, + 3782.492, + 1485.6129999999998, + 505.02400000000034 + ], + "priority": 18, + "parents": [ + 163953 + ], + "children": [], + "area": 6535514.499836001, + "iscrowd": 0, + "segmentation": [], + "text": "* BOLD is negatively correlated with the power of the lower\nfrequency icEEG components (<60HZ); and positively correlated with\nthe higher ones (>80Hz).\n\n* The phase of beta has an influence on the EEG-BOLD correlation\nstrength.\n\n* BOLD is negatively correlated with the PAC strength between the\nphase of beta and the amplitude of various icEEG frequency\ncomponents." + }, + { + "id": 163962, + "strid": "fb2cf619-9a59-469a-b4f9-a3fdc1b97a33", + "image_id": 206897, + "image_name": "6606.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 637.221, + 4446.539, + 2034.1259999999997, + 150.3050000000003 + ], + "priority": 19, + "parents": [ + 163967 + ], + "children": [], + "area": 2833428.0281189997, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgments: This research was funded by the Portuguese Science Foundation through the PhD grant\nSFRH/BD/80421/2011 and supported by the National Institute for Health Research University College London\nHospitals Biomedical Research Centre." + }, + { + "id": 49910, + "strid": "84c91f14-a2c7-4a6f-ab4b-a12602691d96", + "image_id": 202457, + "image_name": "11872.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 27.26, + 119.71, + 184.8, + 162.62 + ], + "priority": -1, + "parents": [], + "children": [ + 49890, + 49896, + 49902, + 49888, + 49889, + 49909 + ], + "area": 3263.2946, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 49888, + "strid": "9e4c26d1-e125-481a-a7a7-df846f4306a3", + "image_id": 202457, + "image_name": "11872.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 242.707, + 173.646, + 2827.491, + 105.32199999999997 + ], + "priority": 1, + "parents": [ + 49910 + ], + "children": [], + "area": 42145.099722, + "iscrowd": 0, + "segmentation": [], + "text": "Pyrexia of Unknown Origin — Interpret all Results with Care!" + }, + { + "id": 49889, + "strid": "12547c03-811d-4d5e-8580-2c3a4751556d", + "image_id": 202457, + "image_name": "11872.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 565.863, + 287.027, + 2174.437, + 40.298 + ], + "priority": 2, + "parents": [ + 49910 + ], + "children": [], + "area": 162417.959301, + "iscrowd": 0, + "segmentation": [], + "text": "Dr. Louise Downs & Dr. David Waghorn, Microbiology Department, Stoke Mandeville Hospital, Buckinghamshire Healthcare NHS Trust." + }, + { + "id": 49890, + "strid": "9c1e107b-9056-4720-b4be-aa2a4748bc12", + "image_id": 202457, + "image_name": "11872.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 116.602, + 472.621, + 261.519, + 41.69100000000003 + ], + "priority": 3, + "parents": [ + 49910 + ], + "children": [ + 49895, + 49891, + 49892, + 49893, + 49897 + ], + "area": 55108.553842, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 49891, + "strid": "d1048683-2afe-42d3-a98c-dd287d5a3609", + "image_id": 202457, + "image_name": "11872.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 117.188, + 529.845, + 1508.897, + 152.745 + ], + "priority": 4, + "parents": [ + 49890 + ], + "children": [], + "area": 62091.475860000006, + "iscrowd": 0, + "segmentation": [], + "text": "Pyrexia of unknown origin (PUO) was first described by Petersdorf and Beeson in\n1961:. Their definitive criteria can still be used today and effectively established\nPUO as a clinical entity:" + }, + { + "id": 49892, + "strid": "279fc53e-7405-4979-b421-af98b975e6f1", + "image_id": 202457, + "image_name": "11872.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 116.495, + 741.896, + 1227.674, + 154.173 + ], + "priority": 5, + "parents": [ + 49890 + ], + "children": [], + "area": 86427.17452, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 49893, + "strid": "74a9e3d1-74cb-472d-a987-bcca43b6d4b0", + "image_id": 202457, + "image_name": "11872.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 114.225, + 956.752, + 1514.446, + 419.73 + ], + "priority": 6, + "parents": [ + 49890 + ], + "children": [], + "area": 109284.99719999998, + "iscrowd": 0, + "segmentation": [], + "text": "An illness of 2 3 weeks duration excludes self limiting viral illnesses and allows\ntime for initial appropriate investigations to be done. The third criteria may include\nfailure to confirm the diagnosis after at least 3 outpatient visits and investigations.\n\nThere are no standardised guidelines as to how to investigate PUO and the\ndifferential diagnosis is vast? (see table 1). The initial choice of tests needs to be\nbased as much as possible on clinical presentation, medical/social/travel history\nand any relevant findings on examination e.g. heart murmur, hepatomegaly etc." + }, + { + "id": 49895, + "strid": "cb07213b-4b65-4a73-8e1d-9a4ad4f17530", + "image_id": 202457, + "image_name": "11872.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 105.507, + 1535.18, + 1537.334, + 1431.256 + ], + "priority": 7, + "parents": [ + 49890 + ], + "children": [ + 49894 + ], + "area": 161972.23626, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 49894, + "strid": "87b4163c-5ff6-4cd1-ab62-35b587dd1599", + "image_id": 202457, + "image_name": "11872.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 113.22, + 1485.543, + 944.4579999999999, + 48.05899999999997 + ], + "priority": 8, + "parents": [ + 49895 + ], + "children": [], + "area": 168193.17846, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1: Causes of Pyrexia of Unknown Origin" + }, + { + "id": 49897, + "strid": "a3707ff7-3d80-46ce-8620-9b47ab379c6e", + "image_id": 202457, + "image_name": "11872.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 115.418, + 3074.084, + 1510.953, + 311.30200000000013 + ], + "priority": 9, + "parents": [ + 49890 + ], + "children": [], + "area": 354804.627112, + "iscrowd": 0, + "segmentation": [], + "text": "Here we present a case of PUO in a recent traveller. The travel history initially led\ninvestigations down the infection route, but the final diagnosis was likely unrelated\nto travel. Abnormal serology revealed a probable recent significant infection but\nnot the ultimate cause of the PUO. This case highlights the need to review\ninvestigations in line with the differential diagnosis for an individual’s PUO and how\nserological results need to be interpreted with care." + }, + { + "id": 49896, + "strid": "ecefe307-fefb-4c1f-822a-e8550deb635b", + "image_id": 202457, + "image_name": "11872.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 115.704, + 3447.794, + 257.853, + 43.33100000000013 + ], + "priority": 10, + "parents": [ + 49910 + ], + "children": [ + 49908, + 49898, + 49905, + 49907, + 49903, + 49899, + 49900 + ], + "area": 398923.55697599996, + "iscrowd": 0, + "segmentation": [], + "text": "Clinical Case" + }, + { + "id": 49898, + "strid": "bbe4ba88-6163-4d92-b4d8-a4d1ca0d0767", + "image_id": 202457, + "image_name": "11872.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 115.66, + 3568.146, + 1511.981, + 203.96799999999985 + ], + "priority": 11, + "parents": [ + 49896 + ], + "children": [], + "area": 412691.76636, + "iscrowd": 0, + "segmentation": [], + "text": "A 49 year old woman presented to the Emergency Department 6 weeks after\narriving in the UK from Australia. She had started to feel generally unwell 10 days\nafter her arrival in the UK but several visits to primary care services failed to\nconfirm a diagnosis. On hospital admission her main symptoms were:" + }, + { + "id": 49899, + "strid": "3c9a3fbb-c0e1-4421-9e95-1dcc0bd3625c", + "image_id": 202457, + "image_name": "11872.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 114.306, + 3835.361, + 1512.747, + 302.1980000000003 + ], + "priority": 12, + "parents": [ + 49896 + ], + "children": [], + "area": 438404.774466, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 49900, + "strid": "33e15f35-0c09-417a-a765-667d55b155a8", + "image_id": 202457, + "image_name": "11872.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 115.341, + 4206.364, + 1511.837, + 314.8800000000001 + ], + "priority": 13, + "parents": [ + 49896 + ], + "children": [], + "area": 485166.23012399994, + "iscrowd": 0, + "segmentation": [], + "text": "She had no headache, ocular symptoms or chest pain. There was also no history of\nabdominal pain, change in bowel habit or urinary symptoms.\n\nThe patient was normally fit and well and taking no regular medications. She\nworked as an accountant, did not smoke and drunk alcohol in moderation. There\nwas no significant sexual history and no history of any familial diseases." + }, + { + "id": 49908, + "strid": "f3e2580c-5ec4-493a-b095-7192ccb37466", + "image_id": 202457, + "image_name": "11872.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1796.642, + 476.77, + 1414.3950000000002, + 260.001 + ], + "priority": 14, + "parents": [ + 49896 + ], + "children": [], + "area": 856585.00634, + "iscrowd": 0, + "segmentation": [], + "text": "Our patient did have an extensive travel history having visited India twice and\nSingapore once in the previous few months. She had been fully vaccinated\nand had not taken malaria prophylaxis. She visited one safari park and a bird\nsanctuary in India. On her trip to the UK she had briefly stopped in Dubai but\nhad not left the airport. Her initial investigations are shown in table 2:" + }, + { + "id": 49907, + "strid": "b7b653c0-b7bc-43f9-a886-fee8fe4da512", + "image_id": 202457, + "image_name": "11872.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1783.753, + 1022.354, + 1442.544, + 1224.4060000000002 + ], + "priority": 15, + "parents": [ + 49896 + ], + "children": [ + 49906 + ], + "area": 1823627.014562, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 49906, + "strid": "cab94b6c-d8dd-4718-9557-42a036ea193e", + "image_id": 202457, + "image_name": "11872.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2123.399, + 960.102, + 761.1060000000002, + 49.48299999999995 + ], + "priority": 16, + "parents": [ + 49907 + ], + "children": [], + "area": 2038679.626698, + "iscrowd": 0, + "segmentation": [], + "text": "Table 2: Initial patient investigations" + }, + { + "id": 49905, + "strid": "a00c2177-1756-454b-a312-027efeba0564", + "image_id": 202457, + "image_name": "11872.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1797.624, + 2370.177, + 1413.4419999999998, + 97.99299999999994 + ], + "priority": 17, + "parents": [ + 49896 + ], + "children": [], + "area": 4260687.059448, + "iscrowd": 0, + "segmentation": [], + "text": "It was not until the emergence of several further results that two possible\ndiagnoses began to emerge (table 3)." + }, + { + "id": 49903, + "strid": "6973ba29-21e2-481a-b00b-240738a9b8c5", + "image_id": 202457, + "image_name": "11872.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1787.049, + 2677.341, + 1438.172, + 294.9540000000002 + ], + "priority": 18, + "parents": [ + 49896 + ], + "children": [ + 49904 + ], + "area": 4784539.556709, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 49904, + "strid": "10090d79-2d41-406e-8466-a9080eab1d70", + "image_id": 202457, + "image_name": "11872.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1794.876, + 2625.978, + 875.6160000000002, + 48.86700000000019 + ], + "priority": 19, + "parents": [ + 49903 + ], + "children": [], + "area": 4713304.888728, + "iscrowd": 0, + "segmentation": [], + "text": "Table 3: Further investigations and results" + }, + { + "id": 49902, + "strid": "85ead59b-a585-4bb7-9f2e-d16a4f1dc383", + "image_id": 202457, + "image_name": "11872.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1797.622, + 3094.626, + 629.1099999999999, + 49.222999999999956 + ], + "priority": 20, + "parents": [ + 49910 + ], + "children": [ + 49901 + ], + "area": 5562967.779372, + "iscrowd": 0, + "segmentation": [], + "text": "Final Diagnosis and Discussion" + }, + { + "id": 49901, + "strid": "02a6be9e-87d7-4549-9408-560452ec71f9", + "image_id": 202457, + "image_name": "11872.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1794.362, + 3211.53, + 1419.1779999999999, + 952.1749999999997 + ], + "priority": 21, + "parents": [ + 49902 + ], + "children": [], + "area": 5762647.39386, + "iscrowd": 0, + "segmentation": [], + "text": "Rheumatology review concluded that the most likely diagnosis was adult\nonset Stills disease, supported by the very high ferritin. However this did not\nexplain the highly abnormal chlamydial serology. The reference lab initially\nconcluded this was consistent with recent C. psittaci infection, but later\naltered their opinion to C. pneumoniae infection, explained by the recognised\nproblem of cross reactivity of antibodies produced against the different\nchlamydia species.\n\nOur patient was started on high dose steroids plus doxycycline to treat both\nchlamydial infection and Still’s disease. Within 3 days her white cell count and\nCRP normalised and her serum ferritin fell to 300ng/mL.\n\nThe final conclusion was that the patient had developed acute onset adult\nStills disease accompanied by recent chlamydial exposure. This case\ndemonstrates how two separate conditions can overlap in their presentation,\nmaking investigation of PUO even more difficult. Travel and/or exposure to\npotential infective sources should not blinker an objective clinical assessment.\nSerology results must always be interpreted carefully — even by the experts!" + }, + { + "id": 49909, + "strid": "304afe57-2c81-4136-bb5e-997509d2c62c", + "image_id": 202457, + "image_name": "11872.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1798.018, + 4376.741, + 1403.422, + 174.54899999999998 + ], + "priority": 22, + "parents": [ + 49910 + ], + "children": [], + "area": 7869459.099338, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143655, + "strid": "00f49bc7-dbb7-487f-9510-1c438faf7f3a", + "image_id": 206082, + "image_name": "17387.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 32.77, + 53.68, + 168.56, + 146.94 + ], + "priority": -1, + "parents": [], + "children": [ + 143627, + 143630, + 143628, + 143625, + 143629, + 143626, + 143624 + ], + "area": 1759.0936000000002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143624, + "strid": "3d453b19-5d63-4473-8e0e-9ff2d2b4e80e", + "image_id": 206082, + "image_name": "17387.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 491.27, + 45.898, + 2901.037, + 109.00800000000001 + ], + "priority": 1, + "parents": [ + 143655 + ], + "children": [], + "area": 22548.31046, + "iscrowd": 0, + "segmentation": [], + "text": "Coral Microbioreactors For\n\nModel Validation" + }, + { + "id": 143625, + "strid": "e5c0b4db-44a8-4f06-8936-e0f4f040cd46", + "image_id": 206082, + "image_name": "17387.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 682.604, + 243.191, + 2509.442, + 261.65199999999993 + ], + "priority": 2, + "parents": [ + 143655 + ], + "children": [], + "area": 166003.149364, + "iscrowd": 0, + "segmentation": [], + "text": "Liza M. Roger’, Isaiah Cuadras?, Hannah G. Reich®, Shuaifeng Li?, Lokender Kumar 4, Jinkyu Yang*°,\nHollie M. Putnam’, Nastassja Lewinski'\n\nVirginia Commonwealth University, Richmond, Virginia, USA; @University of Washington, Seattle, Washington, USA; *University of Rhode Island,\nKingston, Rhode Island, USA; *Colorado School of Mines, Golden, Colorado, USA; 5 Seoul National University, Seoul, South Korea" + }, + { + "id": 143626, + "strid": "755f09c2-7da6-441c-b3cb-94f510904468", + "image_id": 206082, + "image_name": "17387.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 339.325, + 570.436, + 339.27000000000004, + 39.29600000000005 + ], + "priority": 3, + "parents": [ + 143655 + ], + "children": [ + 143648, + 143647, + 143650, + 143649, + 143631 + ], + "area": 193563.1957, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 143647, + "strid": "4dcb421a-3c14-4d84-9782-b4dd35226eac", + "image_id": 206082, + "image_name": "17387.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 60.636, + 423.0, + 240.00500000000002, + 942.8789999999999 + ], + "priority": 4, + "parents": [ + 143626 + ], + "children": [ + 143638 + ], + "area": 25649.028000000002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143638, + "strid": "a737b058-f75c-42a7-a983-f68cf534cc37", + "image_id": 206082, + "image_name": "17387.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 62.736, + 1383.328, + 273.377, + 34.330999999999904 + ], + "priority": 5, + "parents": [ + 143647 + ], + "children": [], + "area": 86784.46540799999, + "iscrowd": 0, + "segmentation": [], + "text": "Fig.1: Coral scale" + }, + { + "id": 143631, + "strid": "e00746e6-d3e3-4c58-a781-a5e4ef15df1b", + "image_id": 206082, + "image_name": "17387.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 333.978, + 634.199, + 1941.774, + 699.4319999999999 + ], + "priority": 6, + "parents": [ + 143626 + ], + "children": [], + "area": 211808.513622, + "iscrowd": 0, + "segmentation": [], + "text": "Advances in coral biology and ecology are hindered by the complexity of the system (symbiotic relationship with dinoflagellate\nalgae, dense and diverse microbiome) and scales at which different mechanisms operate. While colony-level studies are\nwidespread, there are fewer single polyp scale and cellular level studies (Fig.1). Coral research has mainly been conducted top-\ndown by testing colony response to describe cellular processes. Developing coral-specific microbioreactors can help us change to\na bottom-up approach that can have the double function of feeding computational models and validating the ensuing predictions.\nThey can, for example, enable us to investigate protein interactions and gene expression applied to the response of corals to\nenvironmental change, toxicity (e.g. microplastics), disease and injury at the cellular level, the polyp level and the colony level.\n\nA number of “coral-on-a-chip” designs have been developed to study micro-scale interactions between corals and _ their\nenvironment but they mainly allow investigations at the polyp scale’ or colony scale (nubbin: colony subset)®>*®. The device by van\nTreuren et al.” presents the highest resolution by trapping individual larvae in a funnel-like channel allowing single-larvae imaging\nduring the experiment (symbiont expulsion during thermal stress-induced bleaching in symbiotic anemone Aiptasia). Despite the\ntechnological advances these devices represent, control of environmental properties and number of replicates remain limited, and\nthe cellular scale has still not been achieved.\n\nThe design presented here offers multiple independent input/output channels to control growth media or treatment parameters\n(flow, temperature, composition), light (for photosynthesis) and live-imaging capabilities (traditional or inverted microscopy) Fig.2-3.\nIt also permits multiple configurations (single chamber or network, Fig.3-4) to study biological interactions at different scale with\nsimple logistics." + }, + { + "id": 143648, + "strid": "e1390b70-380d-408b-9b22-e32ade547bb9", + "image_id": 206082, + "image_name": "17387.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 50.861, + 1514.058, + 650.435, + 516.3789999999999 + ], + "priority": 7, + "parents": [ + 143626 + ], + "children": [ + 143639 + ], + "area": 77006.503938, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143639, + "strid": "e7509d5c-0546-410c-a1ce-e1dae03db518", + "image_id": 206082, + "image_name": "17387.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 65.46, + 1458.382, + 437.639, + 34.325000000000045 + ], + "priority": 8, + "parents": [ + 143648 + ], + "children": [], + "area": 95465.68572, + "iscrowd": 0, + "segmentation": [], + "text": "Fig.2: Parameters to control" + }, + { + "id": 143649, + "strid": "b43f8be8-b868-4c03-820c-ae9781770f0e", + "image_id": 206082, + "image_name": "17387.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 746.37, + 1402.382, + 857.246, + 719.5239999999999 + ], + "priority": 9, + "parents": [ + 143626 + ], + "children": [ + 143640 + ], + "area": 1046695.85334, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143640, + "strid": "7f442e86-9716-425f-b4bc-8c33256e3114", + "image_id": 206082, + "image_name": "17387.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 746.711, + 1414.191, + 353.82400000000007, + 34.718000000000075 + ], + "priority": 10, + "parents": [ + 143649 + ], + "children": [], + "area": 1055991.9758010001, + "iscrowd": 0, + "segmentation": [], + "text": "Fig.3: Chamber design" + }, + { + "id": 143650, + "strid": "954d535c-3a96-45f9-9803-65c289572909", + "image_id": 206082, + "image_name": "17387.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1684.644, + 1483.854, + 616.4199999999998, + 363.222 + ], + "priority": 11, + "parents": [ + 143626 + ], + "children": [ + 143641 + ], + "area": 2499765.737976, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143641, + "strid": "4a783d6d-39be-4ad6-ac62-b6cabfb73fbc", + "image_id": 206082, + "image_name": "17387.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1691.285, + 1423.598, + 447.7479999999998, + 34.44200000000001 + ], + "priority": 12, + "parents": [ + 143650 + ], + "children": [], + "area": 2407709.94343, + "iscrowd": 0, + "segmentation": [], + "text": "Fig.4: Network configuration" + }, + { + "id": 143627, + "strid": "91431792-dc07-48e6-aac9-258a18f3fc89", + "image_id": 206082, + "image_name": "17387.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 48.819, + 2089.797, + 538.99, + 39.68899999999985 + ], + "priority": 13, + "parents": [ + 143655 + ], + "children": [ + 143633, + 143637, + 143634 + ], + "area": 102021.79974300001, + "iscrowd": 0, + "segmentation": [], + "text": "2. Materials & Methods" + }, + { + "id": 143633, + "strid": "76536420-273f-4804-89a7-ce51b1b91c9e", + "image_id": 206082, + "image_name": "17387.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 48.075, + 2161.326, + 630.78, + 882.0720000000001 + ], + "priority": 14, + "parents": [ + 143627 + ], + "children": [], + "area": 103905.74745000001, + "iscrowd": 0, + "segmentation": [], + "text": "Chamber design — Reef-building corals\nrequire specific environmental conditions\n(e.g. light, temperature, salinity, pH,\nnutrient, ammonia). This device was\ndesigned to enable control over irradiance\n(transparent material VeroClear®),\ntemperature (external heat source or\nheated media), flow (9 input/outputs,\nFig.3), media composition,\nphotosynthesis, gas exchange and\nexperimental treatment while allowing\nobservation using microscopy (top and/or\nbottom) Fig.2-3. This octagonal\nmicrofluidic device also offers the potential\nfor single or multiple well configuration\n(Fig.4, well volume: 3.62 cm’), which\nallows investigations at multiple scale\n(cell0.05)" + }, + { + "id": 151725, + "strid": "f5fad601-0901-42c2-9511-700ed58fd64d", + "image_id": 206403, + "image_name": "21314.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1759.089, + 2832.575, + 561.806, + 52.97200000000021 + ], + "priority": 29, + "parents": [ + 151705 + ], + "children": [], + "area": 4982751.524174999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 151707, + "strid": "ce730276-ed94-4087-81ed-26c51f0b0993", + "image_id": 206403, + "image_name": "21314.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1565.104, + 2939.447, + 379.2919999999999, + 28.192000000000007 + ], + "priority": 30, + "parents": [ + 151735 + ], + "children": [ + 151724 + ], + "area": 4600540.257488, + "iscrowd": 0, + "segmentation": [], + "text": "Key Findings and Conclusions" + }, + { + "id": 151724, + "strid": "ee73b7d3-b97a-4bfa-a98f-554073a8a33b", + "image_id": 206403, + "image_name": "21314.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1191.189, + 2976.972, + 1099.1489999999997, + 158.25599999999986 + ], + "priority": 31, + "parents": [ + 151707 + ], + "children": [], + "area": 3546136.2997080004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 151708, + "strid": "9567566d-f249-4e99-b49b-2851a6a7d467", + "image_id": 206403, + "image_name": "21314.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1682.996, + 3161.804, + 144.80500000000006, + 22.434000000000196 + ], + "priority": 32, + "parents": [ + 151735 + ], + "children": [ + 151723 + ], + "area": 5321303.484784001, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 151723, + "strid": "a0eacbb5-c970-4ba1-be23-c049e8f9a500", + "image_id": 206403, + "image_name": "21314.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 23.356, + 3210.097, + 2257.902, + 78.48599999999988 + ], + "priority": 33, + "parents": [ + 151708 + ], + "children": [], + "area": 74975.02553200001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 58924, + "strid": "c4b51a41-3fe6-4c92-b1d3-eebaf4ecec84", + "image_id": 202829, + "image_name": "11932.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 99.12, + 25.2, + 73.29999999999998, + 53.75999999999999 + ], + "priority": -1, + "parents": [], + "children": [ + 58902, + 58901, + 58919, + 58904, + 58905, + 58920, + 58900, + 58903 + ], + "area": 2497.824, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 58905, + "strid": "8e898a0d-169c-4082-a763-aa92687e24e0", + "image_id": 202829, + "image_name": "11932.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 188.994, + 35.501, + 433.803, + 39.781 + ], + "priority": 1, + "parents": [ + 58924 + ], + "children": [], + "area": 6709.475993999999, + "iscrowd": 0, + "segmentation": [], + "text": "LA MIOSTATINA: REGULADOR DEL CRECIMIENTO MUSCULAR Y\nALTERNATIVA PARA LA SALUD" + }, + { + "id": 58904, + "strid": "3115d003-0d23-457a-81e7-2303c6ae0fc2", + "image_id": 202829, + "image_name": "11932.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 164.907, + 94.501, + 484.9, + 64.28 + ], + "priority": 2, + "parents": [ + 58924 + ], + "children": [], + "area": 15583.876407000002, + "iscrowd": 0, + "segmentation": [], + "text": "Cabanillas Elizabeth’, Cordova Andrea’ & Roberto Pineda*\n\n‘Alumnos de Biinformatica de la Facultad de Ciencias Bioligicas de la Universidad Ricardo Palma (URP)\n2Dooente de Bioinformatica de la Facultad de Ciencias Biologicas de la Universidad Ricardo Palma (URP)" + }, + { + "id": 58901, + "strid": "e7082005-942f-4174-a593-94ad73f24893", + "image_id": 202829, + "image_name": "11932.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 371.665, + 203.059, + 81.80400000000003, + 17.48400000000001 + ], + "priority": 3, + "parents": [ + 58924 + ], + "children": [ + 58906 + ], + "area": 75469.92323500001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 58906, + "strid": "2c8dd693-1cc0-45ce-af4a-32168819a42f", + "image_id": 202829, + "image_name": "11932.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 25.468, + 230.351, + 776.082, + 88.14100000000002 + ], + "priority": 4, + "parents": [ + 58901 + ], + "children": [], + "area": 5866.579268, + "iscrowd": 0, + "segmentation": [], + "text": "La miostatina (MSTN) también conocida como la GDF8, 96 un regulador negative del crecimienio del musculo eequelético y responsable del correcto\ndesarrollo de la masa muscular. Su expresion esté determinada por muchos mecanismos especificos, por ejemplo dominio de proteinas especiticas y\ngenes relacionados. A su vez también, tamibién se obtuvo informacién acerca de su influencia en determinadas enfermedades que aquejan a nivel de los.\ntejidos musculares como por ejemplo sarcopenia y también relacionandose con el gen FTO (gen de la obesidad). La revision de la literatura d acerca de la\nexpresion de esta proteina deja en claro que el buen manejo de esta mediante el uso de la Ingenieria Genética, podria ayudar aliviar estos males que\ndebilitan de forma progresiva el sistema esquelético, debilitando el movimiento de las personas." + }, + { + "id": 58902, + "strid": "3791c2fd-cf30-4e68-9fc6-685557f70c33", + "image_id": 202829, + "image_name": "11932.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 149.092, + 341.173, + 127.32500000000002, + 19.786999999999978 + ], + "priority": 5, + "parents": [ + 58924 + ], + "children": [ + 58909 + ], + "area": 50866.164916, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 58909, + "strid": "e5503aa1-351d-4243-996c-170fd7302d1f", + "image_id": 202829, + "image_name": "11932.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 28.502, + 376.291, + 372.975, + 113.043 + ], + "priority": 6, + "parents": [ + 58902 + ], + "children": [], + "area": 10725.046081999999, + "iscrowd": 0, + "segmentation": [], + "text": "La miostatina (MSTN) también conocida como la GDF8, es un reguiador\nnegativo del crecimiento del musculo esquelético y responsable del\ncorracto desarrollo de la masa muscular. Me Phorron A. (1997).\n\nLa disfuncion del gen MSTN, ya sea por mutacion natural o inducida a\ntravés de la manipulacion genética (knockout 0 knockdown) ha sido\nreportada para aumentar la masa muscular en especies de mamiferos.\n\nEn otras Investigaciones se han encontrado concentraciones atlas de\nmiostatina en personas afectadas por el virus VIH que tenian pérdias de\nmasa corporal. Authier et al. (2005)" + }, + { + "id": 58903, + "strid": "b6eadc34-0433-4389-a79c-9ce4b6738f84", + "image_id": 202829, + "image_name": "11932.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 116.888, + 516.266, + 201.013, + 23.374000000000024 + ], + "priority": 7, + "parents": [ + 58924 + ], + "children": [ + 58921, + 58914, + 58912, + 58911, + 58913, + 58922, + 58908, + 58923 + ], + "area": 60345.300208, + "iscrowd": 0, + "segmentation": [], + "text": "DISENO METODOLOGICO" + }, + { + "id": 58908, + "strid": "080b8cb8-1b3b-4789-9f80-662da4746abb", + "image_id": 202829, + "image_name": "11932.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 28.986, + 557.352, + 367.634, + 71.54600000000005 + ], + "priority": 8, + "parents": [ + 58903 + ], + "children": [], + "area": 16155.405072, + "iscrowd": 0, + "segmentation": [], + "text": "Para la simulacion o prediccion de estructura de la MSTN se utilizaron\nprogramas que simulaban la configuracién de ellas, estas son descritas a\ncontinuacién:\n\nSecuencia de MSTN" + }, + { + "id": 58911, + "strid": "a7a64d7a-d851-4f0a-a992-5a1b9226dd32", + "image_id": 202829, + "image_name": "11932.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 93.486, + 646.432, + 249.09700000000004, + 60.94100000000003 + ], + "priority": 9, + "parents": [ + 58903 + ], + "children": [], + "area": 60432.341952, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 58921, + "strid": "24679464-b5b4-41ad-ab08-e99ae4e08ca2", + "image_id": 202829, + "image_name": "11932.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 28.8, + 723.549, + 123.48800000000001, + 12.833999999999946 + ], + "priority": 10, + "parents": [ + 58903 + ], + "children": [], + "area": 20838.2112, + "iscrowd": 0, + "segmentation": [], + "text": "Meceptores de la MSIN:" + }, + { + "id": 58912, + "strid": "c8b87f41-1044-4762-8d70-d6f24a01f053", + "image_id": 202829, + "image_name": "11932.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 126.626, + 761.407, + 180.42799999999997, + 121.35400000000004 + ], + "priority": 11, + "parents": [ + 58903 + ], + "children": [], + "area": 96413.92278200001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 58922, + "strid": "8161ed45-b5d3-447e-9e2d-246fa9483804", + "image_id": 202829, + "image_name": "11932.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 27.945, + 897.517, + 116.929, + 12.263000000000034 + ], + "priority": 12, + "parents": [ + 58903 + ], + "children": [], + "area": 25081.112565000003, + "iscrowd": 0, + "segmentation": [], + "text": "Estructura de la MSTN:" + }, + { + "id": 58914, + "strid": "abb3481a-11ee-46f8-95db-758e5c456933", + "image_id": 202829, + "image_name": "11932.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 92.632, + 942.253, + 247.894, + 77.81399999999996 + ], + "priority": 13, + "parents": [ + 58903 + ], + "children": [], + "area": 87282.77989600001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 58923, + "strid": "d331090a-6b5c-430e-ad43-0ed2c8138b16", + "image_id": 202829, + "image_name": "11932.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 28.23, + 1035.265, + 360.233, + 14.286000000000058 + ], + "priority": 14, + "parents": [ + 58903 + ], + "children": [], + "area": 29225.530950000004, + "iscrowd": 0, + "segmentation": [], + "text": "Chimera (Obtener la estructura de la proteina y eliminar los anticuerpos)." + }, + { + "id": 58913, + "strid": "c93822dd-4b09-4399-9988-42533db9ab42", + "image_id": 202829, + "image_name": "11932.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 136.384, + 1050.223, + 160.34899999999996, + 82.0920000000001 + ], + "priority": 15, + "parents": [ + 58903 + ], + "children": [], + "area": 143233.613632, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 58900, + "strid": "9ec60df6-1b19-4060-a7b9-cbc99caa9bbe", + "image_id": 202829, + "image_name": "11932.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 592.775, + 339.804, + 48.581999999999994, + 16.101 + ], + "priority": 16, + "parents": [ + 58924 + ], + "children": [ + 58907, + 58917, + 58916, + 58915 + ], + "area": 201427.31609999997, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 58907, + "strid": "de10c6b9-1f5e-409d-8fed-41e70aa26d8d", + "image_id": 202829, + "image_name": "11932.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 432.633, + 369.252, + 369.38500000000005, + 160.41399999999993 + ], + "priority": 17, + "parents": [ + 58900 + ], + "children": [], + "area": 159750.600516, + "iscrowd": 0, + "segmentation": [], + "text": "En otro modelo como ratones Knock-Out (sin gen de la miogtatina) se ha\npodido observar una reduccién de la masa de tejido adipaso (graso) y un\naumento de la sensibiidad a la insulina lo que mejora el metabolismo de\nla glucosa a través de la via AMPK(proteina quinasa activada por AMP)\nademas del aumento de musculatura. El bajo porceniaje de grasa de las\nespecies bovinas con mutaciones en la miostatina se debe a su alta tasa\nmetabdlica a consecuencia de la gran musculatura que poseen, el\nmusculo es un tejido metabélicamente muy activo y que requiore de\nmucha energia para poder llevar a cabo sus funciones, es por ella los %\nde grasa de estos animales rondan en torno el 10% sin modificar habitos\nalimenticios ni ejercicio. (Santos et al. 2013)." + }, + { + "id": 58915, + "strid": "0450252c-cb60-42eb-9948-278c10f0cc98", + "image_id": 202829, + "image_name": "11932.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 479.982, + 546.453, + 91.10999999999996, + 185.375 + ], + "priority": 18, + "parents": [ + 58900 + ], + "children": [], + "area": 262287.603846, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 58916, + "strid": "0561f9c2-db14-4976-a17f-09a5f0e68d4c", + "image_id": 202829, + "image_name": "11932.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 599.647, + 546.611, + 161.0, + 119.35000000000002 + ], + "priority": 19, + "parents": [ + 58900 + ], + "children": [ + 58899 + ], + "area": 327773.64631700004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 58899, + "strid": "a8a9a5c9-ad11-422f-b703-082c3426ebe7", + "image_id": 202829, + "image_name": "11932.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 615.746, + 670.494, + 115.18500000000006, + 21.20500000000004 + ], + "priority": 20, + "parents": [ + 58916 + ], + "children": [], + "area": 412853.998524, + "iscrowd": 0, + "segmentation": [], + "text": "Figura 2. Flatanes KNCKOUT\n‘eoteeciéa do ln lontating)" + }, + { + "id": 58917, + "strid": "10716535-4fd9-41b8-8c2e-bfb502f24521", + "image_id": 202829, + "image_name": "11932.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 639.956, + 707.375, + 68.39099999999996, + 19.010999999999967 + ], + "priority": 21, + "parents": [ + 58900 + ], + "children": [], + "area": 452688.8755, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 58919, + "strid": "c467355b-b885-48bf-9581-1134f31dc483", + "image_id": 202829, + "image_name": "11932.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 545.455, + 753.915, + 132.52300000000002, + 19.326000000000022 + ], + "priority": 22, + "parents": [ + 58924 + ], + "children": [ + 58910 + ], + "area": 411226.70632500004, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 58910, + "strid": "9c8b400b-fc2a-4087-869d-e1091f5c4bc4", + "image_id": 202829, + "image_name": "11932.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 426.285, + 785.885, + 369.4030000000001, + 145.313 + ], + "priority": 23, + "parents": [ + 58919 + ], + "children": [], + "area": 335010.987225, + "iscrowd": 0, + "segmentation": [], + "text": "El analisis de la bibliografia utilizada en este review permite analizar las\nInterrelaciones moleculares muy especificas las cuales permiten la\n‘expresion del gen de la miostatina como reguladar de indice de masa\n‘muscular, el cual no solo delimita su uso en su funcién principal (aumento\nde la masa muscular) sino que ademas, también se da a conocer como\nuna posible solucién a enfermedades que en la actualidad aquejan a\n‘muchas personas como lo son la diabetes tipo 2, la obesidad y atrofias\n‘musculares ya sea por tomas congénitos o adquiridos. La Ingenieria\nGenetica podria ser una via de uso muy prometedor para la cura de\n‘estos males." + }, + { + "id": 58920, + "strid": "8d3ec325-31c9-41b8-9662-6444558519f8", + "image_id": 202829, + "image_name": "11932.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 553.343, + 961.378, + 119.11299999999994, + 20.903999999999996 + ], + "priority": 24, + "parents": [ + 58924 + ], + "children": [ + 58918 + ], + "area": 531971.7866539999, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 58918, + "strid": "34a61cc6-ce37-4d49-aaae-ec983662619e", + "image_id": 202829, + "image_name": "11932.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 429.102, + 996.875, + 354.635, + 116.4090000000001 + ], + "priority": 25, + "parents": [ + 58920 + ], + "children": [], + "area": 427761.05624999997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 87048, + "strid": "aa15c290-9328-47ec-b601-27fdf0e0fe6f", + "image_id": 203883, + "image_name": "121094.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 44.55, + 67.46, + 110.88000000000001, + 88.71 + ], + "priority": -1, + "parents": [], + "children": [ + 87032, + 87034, + 87047, + 87044, + 87031, + 87038, + 87030 + ], + "area": 3005.3429999999994, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 87030, + "strid": "e185d4e8-385f-4663-8020-f870200a4e89", + "image_id": 203883, + "image_name": "121094.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 1636.912, + 130.112, + 1508.832, + 394.437 + ], + "priority": 1, + "parents": [ + 87048 + ], + "children": [], + "area": 212981.894144, + "iscrowd": 0, + "segmentation": [], + "text": "Computational approaches to\nimproving MIRNA - MRNA\nnis Interaction predictions" + }, + { + "id": 87031, + "strid": "a116ba4d-a366-4f68-8f6e-9ee91635bc60", + "image_id": 203883, + "image_name": "121094.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 97.617, + 449.498, + 1652.59, + 77.80400000000003 + ], + "priority": 2, + "parents": [ + 87048 + ], + "children": [], + "area": 43878.646266, + "iscrowd": 0, + "segmentation": [], + "text": "Maciej Pajak'’*, Clive R. Bramham/?, T.Jan Simpson\"?" + }, + { + "id": 87032, + "strid": "6d2365b5-0d38-4fd8-9cd2-1aa15c0ddbe7", + "image_id": 203883, + "image_name": "121094.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 129.706, + 808.574, + 355.4789999999999, + 67.61800000000005 + ], + "priority": 3, + "parents": [ + 87048 + ], + "children": [ + 87033 + ], + "area": 104876.89924399999, + "iscrowd": 0, + "segmentation": [], + "text": "Background" + }, + { + "id": 87033, + "strid": "837a1d3c-56c4-4fd9-aad8-2193d2e7bb78", + "image_id": 203883, + "image_name": "121094.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 122.068, + 893.603, + 1395.3, + 293.88199999999995 + ], + "priority": 4, + "parents": [ + 87032 + ], + "children": [], + "area": 109080.33100399999, + "iscrowd": 0, + "segmentation": [], + "text": "MicroRNAs (miRNAs) are 20-22nt long transcripts that form protein\ncomplexes which bind to mRNA«and decrease the translation rate of\nthe target mRNA. An ongoing ‘problem in miRNA research is target\nprediction, as identifying targets is necessary for biological\ninterpretation of the findings." + }, + { + "id": 87034, + "strid": "98680997-359e-431d-a8c9-606dcfdba07d", + "image_id": 203883, + "image_name": "121094.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 132.29, + 1296.093, + 661.873, + 70.27600000000007 + ], + "priority": 5, + "parents": [ + 87048 + ], + "children": [ + 87036, + 87035, + 87037 + ], + "area": 171460.14297, + "iscrowd": 0, + "segmentation": [], + "text": "Target list.aggregation" + }, + { + "id": 87035, + "strid": "464c252b-4a12-4d19-955c-cc73987311bb", + "image_id": 203883, + "image_name": "121094.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 122.068, + 1379.147, + 1441.299, + 231.27199999999993 + ], + "priority": 6, + "parents": [ + 87034 + ], + "children": [], + "area": 168349.71599599998, + "iscrowd": 0, + "segmentation": [], + "text": "Four main_target prediction sources at the moment include: Pictar,\nMiranda,\\TargetScan, DIANA. However, there_is poor convergence\nbetween’ them even though they are all based-on’ canonical binding —\n2-7. nt 5' end of miRNA to 3' UTR of mRNA,as‘well as site conservation." + }, + { + "id": 87036, + "strid": "8e8d6543-f931-4024-adcb-c2afe00c7055", + "image_id": 203883, + "image_name": "121094.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 330.341, + 1619.597, + 928.409, + 415.0339999999999 + ], + "priority": 7, + "parents": [ + 87034 + ], + "children": [], + "area": 535019.292577, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 87037, + "strid": "47b3df72-4d87-437d-b1f3-aa4be743f95f", + "image_id": 203883, + "image_name": "121094.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 117.769, + 2052.474, + 1457.36, + 488.40599999999995 + ], + "priority": 8, + "parents": [ + 87034 + ], + "children": [], + "area": 241717.81050600004, + "iscrowd": 0, + "segmentation": [], + "text": "In order to improve,predictions and reduce noise at the top of the list\nwe propose a method of aggregating existing predictions, where the\naggregated rankyis calculated according to the equation:\n\nAggregate =— wr geo X — wll X,;\n\nisn\n\nwhere is the number of sources which returned the gene and X. is\n\nitsprank in i-th source. To appear in the aggregated list a target needs\nto appear in at least 2 or 3 source lists." + }, + { + "id": 87038, + "strid": "5efe4cb9-e769-4b7f-842c-291a02f10290", + "image_id": 203883, + "image_name": "121094.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 129.553, + 2677.057, + 1107.7510000000002, + 72.01699999999983 + ], + "priority": 9, + "parents": [ + 87048 + ], + "children": [ + 87039, + 87040 + ], + "area": 346820.76552099996, + "iscrowd": 0, + "segmentation": [], + "text": "Bioconductor R package miRNAtap" + }, + { + "id": 87039, + "strid": "b2d09bb9-c0fb-48d1-a25a-32ec289d436e", + "image_id": 203883, + "image_name": "121094.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 126.934, + 2762.168, + 1433.791, + 542.0909999999999 + ], + "priority": 10, + "parents": [ + 87038 + ], + "children": [], + "area": 350613.032912, + "iscrowd": 0, + "segmentation": [], + "text": "miRNAtap provides the.implementation of ranked target list\naggregation method. It allows for programmatic access to aggregated\nmiRNA target predictions. Direct predictions are available for. Homo\nsapiens and Mus\\musculus, predictions for Rattus norvegicus (and\nother species in»the future) are derived through homologytransfer.\n\nIt is particularly useful for longer workflows where ranked target data\ncan be used in further analysis, e.g. interaction>networks, GO or\npathways. The package is available on Bioconductor, the data is stored\ninsanannotation package miRNAtap. db (also on Bioconductor)." + }, + { + "id": 87040, + "strid": "614b2364-c043-4cdd-b3a5-381eb948d7e6", + "image_id": 203883, + "image_name": "121094.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 128.244, + 3347.468, + 1491.539, + 830.1220000000003 + ], + "priority": 11, + "parents": [ + 87038 + ], + "children": [], + "area": 429292.686192, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 87047, + "strid": "ee361e68-e6f8-41d6-98a2-7be2c3e36674", + "image_id": 203883, + "image_name": "121094.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1732.174, + 805.619, + 326.0039999999999, + 65.20100000000002 + ], + "priority": 12, + "parents": [ + 87048 + ], + "children": [ + 87046, + 87045 + ], + "area": 1395472.285706, + "iscrowd": 0, + "segmentation": [], + "text": "Evaluation" + }, + { + "id": 87046, + "strid": "14888980-86c8-4fce-843c-f133e5d9e602", + "image_id": 203883, + "image_name": "121094.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1726.74, + 889.837, + 1450.718, + 725.3589999999999 + ], + "priority": 13, + "parents": [ + 87047 + ], + "children": [], + "area": 1536517.14138, + "iscrowd": 0, + "segmentation": [], + "text": "We evaluated our system based on,» Precision vs. Recall and we\ncompared it to the four algorithms used as sources of predictions\n(Pictar, Miranda, TargetScan, DIANA): We used a sample of 160 human\nmiRNAs which had at least 10\\confirmed targets. Ground truth data\ncome from miRTarBase (2014) and include experimentally confirmed\ninteractions observed in‘various different data collection protocols;we\ndid not differentiate between data collection protocols.\n\nOverall, we observed’ improvement over single source predictions,\nmiRNAtap aggregation with minimum 3 sources (Agg3) achieves\nhigher precision at the top of the list than aggregationwith minimum\n2 sources(Agg2) but there is a trade off with recalh We recommend\nusing different parameters depending on the use.case." + }, + { + "id": 87045, + "strid": "88be7cc4-ee32-40d8-87ab-7ab408ca74d4", + "image_id": 203883, + "image_name": "121094.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2001.127, + 1628.78, + 922.3200000000002, + 585.4489999999998 + ], + "priority": 14, + "parents": [ + 87047 + ], + "children": [], + "area": 3259395.63506, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 87044, + "strid": "dcabd8a6-017e-4108-87ea-459db4c6a253", + "image_id": 203883, + "image_name": "121094.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1732.174, + 2355.497, + 850.3270000000002, + 69.27599999999984 + ], + "priority": 15, + "parents": [ + 87048 + ], + "children": [ + 87043, + 87042, + 87041 + ], + "area": 4080130.6604779996, + "iscrowd": 0, + "segmentation": [], + "text": "Learning features from data" + }, + { + "id": 87043, + "strid": "03d3a887-fe0a-48e3-a7f2-dfa6a31d8d6a", + "image_id": 203883, + "image_name": "121094.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1730.815, + 2435.64, + 1449.3600000000001, + 421.08899999999994 + ], + "priority": 16, + "parents": [ + 87044 + ], + "children": [], + "area": 4215642.2466, + "iscrowd": 0, + "segmentation": [], + "text": "In our future work we propose an alternative approach to miRNA\ntarget prediction by training a classifier on experimental data.\n\nFirst, prior on initial sequence matches is-determined by co-expression\ndata. Then features such as sequence, signatures, quality of the match\nand binding site context (as used-in TargetScan) are used to calculate\nthe probability of the initial Match being a meaningful interaction.\nInformative features are learned from the training set." + }, + { + "id": 87042, + "strid": "91f64b2e-3f2a-4982-b2d1-6a39e652c1df", + "image_id": 203883, + "image_name": "121094.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1976.97, + 2882.422, + 823.3109999999999, + 465.808 + ], + "priority": 17, + "parents": [ + 87044 + ], + "children": [], + "area": 5698461.82134, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 87041, + "strid": "85044955-946f-4e7e-bdd0-7444129e4197", + "image_id": 203883, + "image_name": "121094.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1729.618, + 3354.663, + 1447.022, + 542.8310000000001 + ], + "priority": 18, + "parents": [ + 87044 + ], + "children": [], + "area": 5802285.508734, + "iscrowd": 0, + "segmentation": [], + "text": "This method benefits from allowing more, mismatches and non-\ncanonical bindings than conventional algorithms, as suggested in a\nrecent CLASH study by Helwak and colleagues (2013), it is also open to\ndiscovery of new sequence patterns.\n\nGold standard data which form ‘the training set for our classifier are\nrapidly accumulating in multiple species and conditions thanks to high\nthroughput techniques suchas HITS-CLIP and CLASH, these data‘are\nlikely to greatly improve*the accuracy and reliability of miRNA target\nprediction in the near future." + }, + { + "id": 104222, + "strid": "d20892a7-30f3-4916-8618-124d61886fd7", + "image_id": 204527, + "image_name": "122289.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 36.12, + 255.37, + 334.14, + 325.98 + ], + "priority": -1, + "parents": [], + "children": [ + 104202, + 104203, + 104207, + 104204, + 104208, + 104209, + 104206 + ], + "area": 9223.964399999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 104202, + "strid": "5ec082df-35fc-448f-bcfa-2feb1c056e58", + "image_id": 204527, + "image_name": "122289.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 180.424, + 64.954, + 3186.381, + 319.607 + ], + "priority": 1, + "parents": [ + 104222 + ], + "children": [], + "area": 11719.260495999999, + "iscrowd": 0, + "segmentation": [], + "text": "EVALUATION OF PHOSPHOCALCIC PROFILE\nIN PATIENTS ON CHRONIC HEMODIALYSIS : COMPRATIVE STUDY BETWEEN\nHEMODIALYSIS BICARBONATE AND ACETATE FREE BIOFILTRATION AT 84%e" + }, + { + "id": 104203, + "strid": "29f27dc2-5b51-4cf4-a9e6-24acd3e073da", + "image_id": 204527, + "image_name": "122289.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 928.017, + 472.188, + 1687.9660000000001, + 131.43999999999994 + ], + "priority": 2, + "parents": [ + 104222 + ], + "children": [], + "area": 438198.491196, + "iscrowd": 0, + "segmentation": [], + "text": "WISSEM ABDELKAFI\nDialysis Department - Principal Military Hospital of Instruction in Tunis, TUNISIA" + }, + { + "id": 104204, + "strid": "dd89e172-1e53-4717-877c-35ebe777373d", + "image_id": 204527, + "image_name": "122289.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1170.143, + 712.008, + 1203.7129999999997, + 62.26099999999997 + ], + "priority": 3, + "parents": [ + 104222 + ], + "children": [ + 104205 + ], + "area": 833151.1771440001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 104205, + "strid": "d3858ef9-1d27-4c57-bbcd-b54c37257866", + "image_id": 204527, + "image_name": "122289.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 77.336, + 848.609, + 3387.571, + 225.1060000000001 + ], + "priority": 4, + "parents": [ + 104204 + ], + "children": [], + "area": 65628.025624, + "iscrowd": 0, + "segmentation": [], + "text": "Disorders of phosphocalcic metabolism remain a daily problems of the patient on chronic hemodialysis, responsible for bone and cardiovascular\ncomplications. The objective of our study is to evaluate the change in phosphocalcic profile in both techniques: Hemodialysis bicarbonate (HDB)\nand acetate free biofiltration at 84 %o (AFB 84 %o)." + }, + { + "id": 104206, + "strid": "4cc0b0a1-1069-4b65-a351-2df8057e160a", + "image_id": 204527, + "image_name": "122289.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 737.415, + 1184.307, + 343.1489999999999, + 54.624000000000024 + ], + "priority": 5, + "parents": [ + 104222 + ], + "children": [ + 104210, + 104216 + ], + "area": 873325.746405, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 104210, + "strid": "08d7d37c-7815-4ff7-a88e-570020122b5e", + "image_id": 204527, + "image_name": "122289.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 74.789, + 1324.297, + 1662.599, + 995.8710000000001 + ], + "priority": 6, + "parents": [ + 104206 + ], + "children": [], + "area": 99042.848333, + "iscrowd": 0, + "segmentation": [], + "text": "Prospective study, cross-over, conducted in the research unit of the\ndialysis department of the Military Hospital of Tunis, over a period of 24\nmonths, including 30 patients treated with HDB periodically, each\npatient had six successive sessions of HBD and 6 successive sessions\nof AFB at 84 %o. A total of 357 sessions is performed, distributed in 180\nsessions HDB and 177 sessions AFB at 84 %o. The mean age of\npatients was 50 + 14.5 years. The sex ratio was 1.14. The average\nlength of hemodialysis was 44 + 46.04 months. For the two\ntechniques, we used a dialysate calcium concentration of 1.5 mmol / L,\nassays of serum calcium and phosphate at the beginning (TO) and end\n(T4) of the first and 4th sessions, as well as rates of parathyroid\nhormone (PTH) in predialysis (tO) of the first and the 6th sessions." + }, + { + "id": 104216, + "strid": "ed8b4f60-c6b3-484d-9a18-dc1bdb2f47f7", + "image_id": 204527, + "image_name": "122289.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 66.484, + 2417.103, + 1674.954, + 1075.315 + ], + "priority": 7, + "parents": [ + 104206 + ], + "children": [ + 104220 + ], + "area": 160698.675852, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 104220, + "strid": "aee5edef-0cb9-4ac6-b600-261a841816dd", + "image_id": 204527, + "image_name": "122289.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 69.367, + 3549.252, + 1237.58, + 59.7170000000001 + ], + "priority": 8, + "parents": [ + 104216 + ], + "children": [], + "area": 246200.963484, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1 : Acetate Free Biofiltration (AFB 84%o)" + }, + { + "id": 104207, + "strid": "87704f29-9163-4fae-b126-713f19756a52", + "image_id": 204527, + "image_name": "122289.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 749.056, + 3706.196, + 313.345, + 53.878000000000156 + ], + "priority": 9, + "parents": [ + 104222 + ], + "children": [ + 104217, + 104214, + 104215, + 104211 + ], + "area": 2776148.350976, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 104211, + "strid": "6c4005ec-d2c5-4f05-a77a-e9eb79c52d8d", + "image_id": 204527, + "image_name": "122289.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 69.162, + 3836.481, + 1671.039, + 1060.5750000000003 + ], + "priority": 10, + "parents": [ + 104207 + ], + "children": [], + "area": 265338.698922, + "iscrowd": 0, + "segmentation": [], + "text": "The analysis of results does not show any significant difference\nbetween the two techniques for serum calcium rate before and during\nthe hemodialysis session, as has the purification of phosphorus. The\ndifference was significant (p <0.05) for the post-dialysis serum calcium\n(T4): 2.32 + 0.25 mmol / L for HDB versus 2.43 + 0.19 mmol / L for\nAFB 84%o. A decrease in PTH rate was observed: 279.39 + 222 ng / ml\nduring the HDB versus 236.69 + 213ng / ml in AFB 84 %o. This\ndecrease was significant (p = 0.013) in favor of the AFB at 84 %o.\n\nThe best correction of metabolic acidosis in Intracellular described for\nthe technique of AFB 84 %o may be in involved by influence of the\nionized fraction of calcium, which increases with metabolic acidosis is\nsubsequently cause of PTH secretion decline observed during this\nstudy." + }, + { + "id": 104214, + "strid": "837dc0a2-0f8c-4862-8e3c-0b9515ce32a7", + "image_id": 204527, + "image_name": "122289.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1819.276, + 1240.887, + 1672.0709999999997, + 787.027 + ], + "priority": 11, + "parents": [ + 104207 + ], + "children": [ + 104221 + ], + "area": 2257515.937812, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 104221, + "strid": "5c6e705f-097e-4ddd-a900-fc90f512f6ff", + "image_id": 204527, + "image_name": "122289.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1836.229, + 1179.238, + 1401.6009999999999, + 44.31400000000008 + ], + "priority": 12, + "parents": [ + 104214 + ], + "children": [], + "area": 2165351.0135020004, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1 : Evolution of serum calcium and phosphate in the HDB and AFB 84 %o" + }, + { + "id": 104217, + "strid": "976db5b7-588f-43f2-8236-a15d554bca31", + "image_id": 204527, + "image_name": "122289.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1894.231, + 2097.103, + 1522.1609999999998, + 971.531 + ], + "priority": 13, + "parents": [ + 104207 + ], + "children": [ + 104218 + ], + "area": 3972397.5127930003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 104218, + "strid": "cd54d545-51f5-434f-a544-cc7503446a4d", + "image_id": 204527, + "image_name": "122289.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1856.754, + 3114.76, + 1585.585, + 95.13500000000022 + ], + "priority": 14, + "parents": [ + 104217 + ], + "children": [], + "area": 5783343.08904, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2 : Histogram of the profile of serum calcium and phosphate\nin the HDB and AFB 84%." + }, + { + "id": 104215, + "strid": "907592bd-fe75-4fc2-8bac-112d0f95917f", + "image_id": 204527, + "image_name": "122289.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1822.159, + 3359.805, + 1672.071, + 438.19799999999987 + ], + "priority": 15, + "parents": [ + 104207 + ], + "children": [ + 104219 + ], + "area": 6122098.918995, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 104219, + "strid": "e287234c-6388-4f73-9e6b-93e1fe78e4ec", + "image_id": 204527, + "image_name": "122289.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1840.28, + 3293.911, + 980.1800000000001, + 47.36200000000008 + ], + "priority": 16, + "parents": [ + 104215 + ], + "children": [], + "area": 6061718.53508, + "iscrowd": 0, + "segmentation": [], + "text": "Table 2 : Evolution of PTH in the HDB and AFB 84 %o" + }, + { + "id": 104208, + "strid": "021492b0-cb50-48d7-b1ae-bfd7f364645d", + "image_id": 204527, + "image_name": "122289.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2417.866, + 3857.906, + 506.1729999999998, + 58.13200000000006 + ], + "priority": 17, + "parents": [ + 104222 + ], + "children": [ + 104212 + ], + "area": 9327899.748596, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 104212, + "strid": "237c24d6-09ac-4dcd-b340-e5b675c08e57", + "image_id": 204527, + "image_name": "122289.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1863.178, + 3996.833, + 1613.5690000000002, + 313.4699999999998 + ], + "priority": 18, + "parents": [ + 104208 + ], + "children": [], + "area": 7446811.315274, + "iscrowd": 0, + "segmentation": [], + "text": "Comparing to the HDB, the AFB to 84 %o, with its good correction of\nacid-base balance, allowed for a better stabilization of phosphocalcic\nratio and consequently a decrease in the stimulation of parathyroid\nglands ascertained by decrease significant PTH rate." + }, + { + "id": 104209, + "strid": "0b14e56b-d293-4615-937b-48726a6addf2", + "image_id": 204527, + "image_name": "122289.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2481.669, + 4412.286, + 375.73099999999977, + 46.78899999999976 + ], + "priority": 19, + "parents": [ + 104222 + ], + "children": [ + 104213 + ], + "area": 10949833.385334, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 104213, + "strid": "97a4296e-20cb-463f-9f2d-77f31d608066", + "image_id": 204527, + "image_name": "122289.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1863.424, + 4521.498, + 1616.426, + 384.45700000000033 + ], + "priority": 20, + "parents": [ + 104209 + ], + "children": [], + "area": 8425467.889152, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 103259, + "strid": "366dcb54-9c30-44f4-90d8-eee9cf25dab4", + "image_id": 204487, + "image_name": "122212.png", + "category_id": 9, + 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Tass in orate 1 te soled\n“dues ESHD where CKD Is ESRD progrestion\npresen bys edt, len, progressive ad tine\ndependent dete incnal ncn, wit recey\nczeanng serum sno vies sarutanecus sir\n 0.9). This allows us to\nfind important changes in the abundance of isoforms associated to\ngenes whose alternative splice changes have been previously\ndescribed to be associated with tumorigenesis" + }, + { + "id": 159218, + "strid": "d5a47f71-6165-4ee4-ba8d-0b9ffa7a21dc", + "image_id": 206719, + "image_name": "6319.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 339.543, + 2113.259, + 977.2399999999999, + 470.52300000000014 + ], + "priority": 12, + "parents": [ + 159211 + ], + "children": [], + "area": 717542.300637, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 159202, + "strid": "588aea9e-eee3-4337-a6e6-7402aa330235", + "image_id": 206719, + "image_name": "6319.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1780.437, + 1706.927, + 1388.496, + 238.52999999999997 + ], + "priority": 13, + "parents": [ + 159211 + ], + "children": [], + "area": 3039075.987099, + "iscrowd": 0, + "segmentation": [], + "text": "Transcript isoform changes are predictive of survival\n\nPredicting the stage of the unannotated samples with our models, we\nobserved a significant difference in the survival for Metastasis (M) and\nLymph Nodes (N)" + }, + { + "id": 159219, + "strid": "9dbc4095-a981-4e0c-b1c0-42ec07d42459", + "image_id": 206719, + "image_name": "6319.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1761.452, + 2046.288, + 680.7929999999999, + 542.9110000000001 + ], + "priority": 14, + "parents": [ + 159211 + ], + "children": [], + "area": 3604438.090176, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 159220, + "strid": "dd9b4f6e-e439-44ab-8ffd-f8cc95fbc748", + "image_id": 206719, + "image_name": "6319.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2487.796, + 2043.825, + 680.7930000000001, + 546.604 + ], + "priority": 15, + "parents": [ + 159211 + ], + "children": [], + "area": 5084619.6597, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 159205, + "strid": 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7292487.022480001, + "iscrowd": 0, + "segmentation": [], + "text": "Negative Label: r(34) = -.16, p = .37\nNegative Match: r(34) = .30, p = .09" + }, + { + "id": 101109, + "strid": "d8d99172-5e94-430c-aff3-fc8f3f2b9e61", + "image_id": 204407, + "image_name": "122062.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4397.157, + 1929.788, + 458.2020000000002, + 63.14599999999996 + ], + "priority": 20, + "parents": [ + 101127 + ], + "children": [ + 101116 + ], + "area": 8485580.812716, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 101116, + "strid": "18235117-68e0-4bef-b19a-3cd95168ceed", + "image_id": 204407, + "image_name": "122062.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3808.994, + 2049.509, + 1603.1680000000001, + 992.8409999999999 + ], + "priority": 21, + "parents": [ + 101109 + ], + "children": [], + "area": 7806567.483946, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 101110, + "strid": "0215f30d-2b09-431d-ae58-468feea1728d", + "image_id": 204407, + "image_name": "122062.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4373.606, + 3119.508, + 504.8590000000004, + 63.62300000000005 + ], + "priority": 22, + "parents": [ + 101127 + ], + "children": [ + 101117 + ], + "area": 13643498.905847998, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 101117, + "strid": "ae3a7db1-2124-420a-bdaf-50246b942968", + "image_id": 204407, + "image_name": "122062.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3808.498, + 3223.86, + 1630.859, + 282.596 + ], + "priority": 23, + "parents": [ + 101110 + ], + "children": [], + "area": 12278064.36228, + "iscrowd": 0, + "segmentation": [], + "text": "Spear (2000). Neuroscience and biobehavioral reviews, 24, 417-63; Caey et al. (2008). Annals of the New\nYork Academy of Science, 1124, 111-26; Dahl (2004). Annals of the New York Academy of Sciences, 1021,\n1-22; Ladouceur (2012). Frontiers in Integrative Neuroscience, 6, 1-11; Angold et al. (1998). Psychological\nMedicine, 28, 51-61; Angold et al. (1999). Psychological Medicine, 29, 1043-53; Mayberg et al. (1999).\nAmerican Journal of Psychiatry, 675-682; Gotlib et al. (2005). Neuroreport, 16, 1731-1734; Drevets et al.\n(2008). CNS Spectrum, 13, 663-81.\n\nThis research was supported by an NSF fellowship (NLC) and NIMH grant_ MH101495-02 (IHG) contact: ncolich@stanford.edu" + }, + { + "id": 117460, + "strid": "2659bd56-4044-47ed-bf3e-389da1a162d7", + "image_id": 205073, + "image_name": "14050.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 296.95, + 51.6, + 160.92000000000002, + 127.39000000000001 + ], + "priority": -1, + "parents": [], + "children": [ + 117457, + 117447, + 117448, + 117456, + 117449, + 117455, + 117450 + ], + "area": 15322.619999999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 117447, + "strid": "52f967d5-d5f5-424e-914b-fa1d6e688904", + "image_id": 205073, + "image_name": "14050.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 600.816, + 50.593, + 2346.893, + 153.752 + ], + "priority": 1, + "parents": [ + 117460 + ], + "children": [], + "area": 30397.083888000005, + "iscrowd": 0, + "segmentation": [], + "text": "KOR ANTRENMANLARININ ATLETIK PERFORMANSA OLAN ETKILERININ\nINCELENMESINE YONELIK DERLEME CALISMASI" + }, + { + "id": 117448, + "strid": "d7eda2f0-865a-4bab-b54e-af19434030ef", + "image_id": 205073, + "image_name": "14050.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 842.413, + 221.816, + 1963.3870000000002, + 180.39699999999996 + ], + "priority": 2, + "parents": [ + 117460 + ], + "children": [], + "area": 186860.682008, + "iscrowd": 0, + "segmentation": [], + "text": "Okan KAMIS*, Tugg¢e KARASAHINOGLU™, H. Ahmet PEKEL”™, Latif AYDOS™\n\n(*) Gazi Universitesi Saglik Bilimleri Enstitist\n(**) Gazi Universitesi Spor Bilimleri Fakiltesi" + }, + { + "id": 117449, + "strid": "c78f187f-5ed7-4d98-a233-1c8ad50704d2", + "image_id": 205073, + "image_name": "14050.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 44.986, + 429.449, + 503.433, + 79.70999999999998 + ], + "priority": 3, + "parents": [ + 117460 + ], + "children": [ + 117452 + ], + "area": 19319.192714, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 117452, + "strid": "d0a6b8ea-7a17-4bdc-b667-447679f83cba", + "image_id": 205073, + "image_name": "14050.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 22.29, + 521.78, + 3499.032, + 282.4200000000001 + ], + "priority": 4, + "parents": [ + 117449 + ], + "children": [], + "area": 11630.4762, + "iscrowd": 0, + "segmentation": [], + "text": "Kor, lokal kuvvet ve denge saglamanin yaninda ayrica sirt agrilarinin azaltilmasinda da 6nem arz eder. Kor stabilite kavraminin tam olarak evrensel bir tanimi yoktur. Kor stabilitenin genel tanimi hareketin kontrolint saglayan, uygun Uretim igin gévdenin hareketini pelvis ve bacak Uzerinden saglamaya izin\n\nveren, bitiinlesik hareketli seri aktivitelerde giciin kontrol ve transferini saglayan ve giict' son bdliime hareket ettiren yetenek olarak tanimlanabilir (Kibler ve digerleri, 2006). Kor kas sistemi, lumbo-pelvik kas kompleksini destekleyen 29 parga kastan olusur. Bu kaslar, fonksiyonel hareketler sirasinda omurganin,\npelvisin ve kinetik zincirin stabilize edilmesine yardimci olur (Fredericson ve Moore, 2005).\n\nKor antrenmanlari teorik olarak atletik performansi birkac¢ sekilde etkiler. Birincisi, teknige faydali olan bel ve pelvisin dengeli olmasini saglar. ikincisi, alt ekstremitelerden st ekstremitelere dogru gicii transfer eden bir arag 6zelligi tagir (disk atma yada gillle atma branginda oldugu gibi). Son olarak, kor\nbdlgesinde ki kaslar atletik performans igin aktif gorev yaparlar (Hedrick, 2000; Kibler ve digerleri, 2006).\n\nKor stabilite ve kor kuvvet 1980’ lerin basindan beri arastirmalara konu olmustur. Arastirmalar daha gok sirt agrisi olan insanlar ve gUnluk aktivitelere katilanlar igin bu antrenmanlarin faydalarini 6n plana gikarmistir. Ancak, kor antrenmanin faydalar! hakkinda ve atletik performans icin antrenmanlarin nasil\n\nuygulanacag! konusunda ¢ok az miktarda arastirma yapilmistir. Bir gok elit sporcu ve antrenGrler geliskili sonuglara ragmen kor stabilite ve kor kuvvet antrenmanlarini programlarina dahil etmislerdir. Bu geliskili sonuglarin baslica sebebi kor stabilite/kuvvet 6lgumlerinde uygulanan net bir standardin olmayisidir\n(Hibbs ve digerleri, 2008).\n\nBu galigmanin amaci baz bireysel ve takim sporlarinda uygulanmis kor antrenmanlarinin atletik performansa olan etkilerini inceleyen bilimsel galigsmalari derleyerek, galismalarda kullanilan yontem (antrenman metodu) ve test bataryalar1 ile elde edilen sonuglar bakimindan degerlendirmektir." + }, + { + "id": 117450, + "strid": "88a1dcf6-92cb-4796-97dc-b5ba052f5389", + "image_id": 205073, + "image_name": "14050.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 74.478, + 849.456, + 249.53199999999998, + 65.22699999999998 + ], + "priority": 5, + "parents": [ + 117460 + ], + "children": [ + 117453, + 117451 + ], + "area": 63265.783967999996, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 117451, + "strid": "8e0e92e9-0ec7-4016-8e3c-acbc22397d6d", + "image_id": 205073, + "image_name": "14050.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 31.815, + 939.373, + 3483.561, + 129.41000000000008 + ], + "priority": 6, + "parents": [ + 117450 + ], + "children": [], + "area": 29886.151995000004, + "iscrowd": 0, + "segmentation": [], + "text": "Bu derleme galigmasinda, 2005-2017 yillari arasinda ingilizce dilinde yayinilanmis kor antrenmanlarinin bazi bireysel ve takim sporlarinda atletik performansa olan etkilerini arastiran makaleler incelenmistir. Literatiir taramasi Gazi Universitesi online kiitjphane sayfasinda yer alan “Scopus, Sciience\nCitation Index, MEDLINE, ScienceDirect ve SPORTDiscus with full Text” veri tabanlarinda “core training” OR “core strength” OR “core stability’ AND “athletic performance” anahtar kelimeleri ile yapilmistir. Tarama sonucunda ilk olarak 2261 makaleye ulasilmistir. Bu calismalardan, tekrar eden (duplicate), farkli\nbilim dallarinda (core-shell, thermal stability, nanostructures, oxydation, temperature gibi) yapilmis olanlar, sporcular Uzerinde yapilmamis olan galigmalar (hastalar, sedanterler, 6grenciler gibi) ve spor branslarini igermeyen galigmalar gikarilarak 43 calismaya indirgenmistir. Son olarak kor antrenmanlarinin atletik\nperformansa olan etkilerini incelemeyen caligmalar da gikarilarak toplam 15 makale degerlendirmeye alinmistir." + }, + { + "id": 117453, + "strid": "e2bb54b3-f48b-4445-80c8-7de4c5916e42", + "image_id": 205073, + "image_name": "14050.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 16.968, + 1097.733, + 3501.624, + 2473.742 + ], + "priority": 7, + "parents": [ + 117450 + ], + "children": [], + "area": 18626.333543999997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 117455, + "strid": "cce7b4a9-86e6-4c82-979c-a85da7a7e5b3", + "image_id": 205073, + "image_name": "14050.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 37.552, + 3594.255, + 357.125, + 61.0630000000001 + ], + "priority": 8, + "parents": [ + 117460 + ], + "children": [ + 117458 + ], + "area": 134971.46376, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 117458, + "strid": "9613732e-e151-4332-aea6-98f5a865f3e1", + "image_id": 205073, + "image_name": "14050.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 32.075, + 3686.775, + 1665.276, + 611.502 + ], + "priority": 9, + "parents": [ + 117455 + ], + "children": [], + "area": 118253.30812500001, + "iscrowd": 0, + "segmentation": [], + "text": "Arastirma kapsaminda erisilen galigmalar takim ve bireysel sporlar olarak iki grupta incelenmistir. Bu galismalardan yedisi takim, sekizi ise\nbireysel spor branslarini igermektedir. Galismalarin gogunda performans dlgumleri dinamik ve statik dengeye dayanmaktadir. Yapilan antrenmanlarin\nsirelerine bakildiginda ise 7 galismada (Myer ve digerleri, 2005; Sato ve Mokha, 2009; Saeterbakken ve digerleri, 2011; Romero-Franco ve digerleri,\n2012; Sandrey ve Mitzel, 2013; Ozmen ve Aydogmus, 2015; Dello lacono ve digerleri, 2016) 6 haftalik antrenman, 6 calismada (Tse ve digerleri,\n2005; Filipa ve digerleri, 2010; Bassett ve Leach , 2011; McCurdy ve arkadaslari, 2014; Yildizer ve Kirazci, 2014; Benis ve digerleri, 2016) 8 haftalik\nantrenman ve sadece 2 calismada (Imai ve digerleri , 2014; Weston ve digerleri, 2015) 12 haftalik antrenman suresinin uygulandig! gorulmustir.\nAtletizm, yizme, jimnastik ve badminton gibi bireysel sporlarda yapilan atletik performans dlgimlerinde gelisim gorulmistir. Bunun sebebinin dlgilen\nperformansliarin kor stabilite antrenmanlarina uygun olmasindan kaynaklandigi dusUnulebilir.\n\nincelenen tim ¢caligmalara bakildiginda elde edilen sonuclara gore kor antrenmanlarinin atletik performans Uzerinde acik sekilde olumlu bir\netkisinin olmadigi sdylenebilir. Fakat yapilan iki galismada (Myer ve digerleri, 2005; Filipa ve digerleri, 2010) kor antrenmanlari piliometrik, surat,\ndenge ve rezistans antrenmanlar gibi néromaskiler antrenman programlari ile bitinlesik sekilde (integrated core training) uygulandiginda\nperformans gelisimlerinin Gnemli dlgUde gelistigi gdriilebilmektedir. Bunun sonucunun diger antrenman tirlerinin etkisinden kaynaklandig!\ndustntlebilir. Yani kor antrenmanlari izole antrenman olarak uygulanmas! yerine diger antrenman tirleri ile bitiinlesik (integrated) sekilde uygulanirsa\ndaha etkili oldugunu sdylenebilir. Yapilan galismalarin tumunde deneysel metod (6n test-son test) yontemi kullanilmistir.\n\nUygulanan kor antrenman tirleri eger spora 6zgii ve dlglilmek istenen performanslar da antrenmanlara yOnelik olursa atletik performansa\nolan etki agik sekilde gérilebilir. Nitekim Sandrey ve Mitzel (2013) tarafindan yapilan galigmada atletlerin dinamik denge performansliari dlgilmek\nistenmis ve antrenman tiru olarak kor stabilite antrenmanlari tercih edilmistir.\n\nLiterati incelendiginde performans gelisimi gdsteren galismalarda cogunlukla galisma grubunu yetiskin sedanterler, hastalar ve\nrekreasyonel aktif 6grenciler olusturmaktadir. Bu agidan bakildiginda kor antrenmanlarinin performansa olumlu etkisinin buyUk oldugunu s6ylenebilir.\nFakat sporcularda atletik performans gelisimini Gnemli 6lgtide artirir diyebilmek igin daha kapsamli arastirmalara ihtiyag duyulmaktadir" + }, + { + "id": 117456, + "strid": "5ce4ff3e-4a96-4729-9d9d-992c323e2e26", + "image_id": 205073, + "image_name": "14050.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 46.976, + 4319.22, + 242.401, + 72.16499999999996 + ], + "priority": 10, + "parents": [ + 117460 + ], + "children": [ + 117459 + ], + "area": 202899.67872, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 117459, + "strid": "b1bb091e-70fd-496b-8780-ed3cb5b21d02", + "image_id": 205073, + "image_name": "14050.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 29.076, + 4418.626, + 1660.873, + 222.94999999999982 + ], + "priority": 11, + "parents": [ + 117456 + ], + "children": [], + "area": 128475.969576, + "iscrowd": 0, + "segmentation": [], + "text": "Sonug olarak, galigmalar incelendiginde kor antrenmanlarinin denge performansini gelistirdigi gorulmekte fakat atletik performansi\ngelistirmesi konusunda kesin bir yargiya ulagilamamaktadir. Yapilan galismalar kor antrenmanlarinin atletik performans Uzerindeki etkisinin orta ve\ndustik seviyede yada hig olmadig! yonuindedir. Ayrica kor stabilite/kuvvet 6lgimlerinde bir standart olmamasindan dolay! atletik performans Uzerindeki\netkilerinin incelenmesi zorlasabilmektedir.\n\nBenzer sonuglar Cissik (2011) tarafindan yapilan derleme calismasinda da g6érlilmistiir. Galismanin sonucuna gore kor antrenmanlarinin\natletik performans Uuzerindeki etkisinin az oldugu gérilmustiir. Antrenman bilim literatUru ve populer medya kor antrenmanlarinin faydalarini\n6vmelerine ragmen literati tam olarak kor antrenmanlarin faydalarini inandiric! bulmamaktadir (Cissik, 2011)." + }, + { + "id": 117457, + "strid": "989ff0bf-1bc6-4133-8c45-9667bfc7ca91", + "image_id": 205073, + "image_name": "14050.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1726.957, + 3577.602, + 427.4399999999998, + 68.46399999999994 + ], + "priority": 12, + "parents": [ + 117460 + ], + "children": [ + 117454 + ], + "area": 6178364.817114, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 117454, + "strid": "ad5d0e8f-f6c8-48d6-93bf-88971858b9a0", + "image_id": 205073, + "image_name": "14050.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1717.513, + 3648.855, + 1800.469, + 1002.2919999999999 + ], + "priority": 13, + "parents": [ + 117457 + ], + "children": [], + "area": 6266955.897615, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 32558, + "strid": "9fd11686-9a63-4cf3-8b94-3c1d413f1ae3", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 2141.13, + 111.95, + 194.03999999999996, + 201.8 + ], + "priority": -1, + "parents": [], + "children": [ + 32515, + 32516, + 32512, + 32514, + 32532, + 32550, + 32513, + 32542, + 32549 + ], + "area": 239699.50350000002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 32512, + "strid": "3267ac51-6c99-4719-a4d4-2fff9fe0a28a", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 47.336, + 114.934, + 1895.169, + 215.59400000000002 + ], + "priority": 1, + "parents": [ + 32558 + ], + "children": [], + "area": 5440.515824, + "iscrowd": 0, + "segmentation": [], + "text": "The added value of, arterial spin labeling for\nclassification of early-stage presenile | dementia" + }, + { + "id": 32513, + "strid": "876fbd99-18f4-47a0-9981-21e824976209", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 39.123, + 406.498, + 3217.476, + 172.47499999999997 + ], + "priority": 2, + "parents": [ + 32558 + ], + "children": [], + "area": 15903.421253999999, + "iscrowd": 0, + "segmentation": [], + "text": "Esther E. Bron +, Rebecc:\n‘Biomedical Imaging Group R\nNetherlands; *Institute of Ne\n\nof Medicine, Imperial College L\n\n. Niessen 78, Marion Smits 2, Stefan Klein 7\n\ns MC, Rotterdam, The Netherlands; ?ASL Europe, GE Healthc Crhe\n\nP-Imagerie du Vivant, Lyon, France; ’Division of Brain SRR culty\npm le TP\n\na-M.E) Steketee 2, Gavin C. Houston 7, Ruth Oliver 4, J nC. van Swieten °*, Alexander Hammers °%, Wir\nbcc) m, Departments of Medical Informatics and Radiology, Er , Rotterdam, The Netherlands; 7Department of Radiology, E:\nogy, University College London, UK; *Department of Neuroloay, Bo us MC, Rotterdam, The Netherlands; Fondation Neurodis, CER\nondon, UK; ®lmaging Science & Technology, Department of Applied Sciences, Delft University of Technology, Delft, The Netherla," + }, + { + "id": 32515, + "strid": "dd849bc5-1c8f-4fd3-8032-81724e9a4301", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 75.914, + 663.018, + 298.562, + 59.363000000000056 + ], + "priority": 3, + "parents": [ + 32558 + ], + "children": [ + 32517 + ], + "area": 50332.348452000006, + "iscrowd": 0, + "segmentation": [], + "text": "HIGHLIGHTS" + }, + { + "id": 32517, + "strid": "aa02367f-ad5f-4403-87b0-5ee3fb56ba1d", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 84.644, + 769.522, + 1506.78, + 183.32799999999997 + ], + "priority": 4, + "parents": [ + 32515 + ], + "children": [], + "area": 65135.42016800001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 32514, + "strid": "5fbd2c1b-df5f-4c75-a63a-5e91352b9f6e", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 79.406, + 1073.323, + 378.877, + 52.378999999999905 + ], + "priority": 5, + "parents": [ + 32558 + ], + "children": [ + 32533, + 32529, + 32528 + ], + "area": 85228.28613800001, + "iscrowd": 0, + "segmentation": [], + "text": "INTRODUCTION" + }, + { + "id": 32529, + "strid": "f6733e03-30c5-4934-b109-711a7175b9a0", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 123.573, + 1159.875, + 479.25800000000004, + 287.55500000000006 + ], + "priority": 6, + "parents": [ + 32514 + ], + "children": [ + 32530 + ], + "area": 143329.23337499998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 32530, + "strid": "aff73274-28f2-45c8-b65f-7a14a254864d", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 74.887, + 1455.037, + 391.013, + 30.429000000000087 + ], + "priority": 7, + "parents": [ + 32529 + ], + "children": [], + "area": 108963.355819, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. Principle of classification" + }, + { + "id": 32528, + "strid": "e0717192-bf72-439d-a532-ee01330b5ad8", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 76.408, + 1493.073, + 559.894, + 366.6700000000001 + ], + "priority": 8, + "parents": [ + 32514 + ], + "children": [ + 32531 + ], + "area": 114082.72178400001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 32531, + "strid": "3a9aa607-6231-4e8c-bf41-d148f1cf5155", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 80.041, + 1877.256, + 548.0330000000001, + 60.548 + ], + "priority": 9, + "parents": [ + 32528 + ], + "children": [], + "area": 150257.447496, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2. CBF map, the arrows point at hypoper-\nfused regions." + }, + { + "id": 32533, + "strid": "9a373dcf-c1b2-4e92-8c3c-c333d85ccb06", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 643.858, + 1196.742, + 956.0829999999999, + 705.095 + ], + "priority": 10, + "parents": [ + 32514 + ], + "children": [], + "area": 770531.9106359999, + "iscrowd": 0, + "segmentation": [], + "text": "Successful classification of dementia can be obtained using ma-\nchine-learning techniques trained on atrophy derived from struc-\ntural MRI [1]. Figure 1 shows the principle of classification.\n\nBecause atrophy in dementia is preceded by hypoperfusion of\nthe brain tissue [2], classification in an early stage of the disease\nmay be advanced by the use of perfusion information. Perfusion\ninformation can be obtained non-invasively with arterial spin la-\nbeling (ASL), an MR technique quantifying cerebral blood flow\n(CBF, Figure 2).\n\nWe aim to evaluate the added value of CBF for classification of\nearly-stage demented patients, suspected of Alzheimer’s disease\n(AD) or frontotemporal dementia (FTD), and healthy controls.\n\nTo detect the features associated with group differences, signifi-\ncance maps (p-maps) were calculated using permutation testing\non the classifier." + }, + { + "id": 32516, + "strid": "a2323902-02d7-4a3b-a43c-16e57f98e8cd", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1724.118, + 659.526, + 385.8609999999999, + 45.39499999999998 + ], + "priority": 11, + "parents": [ + 32558 + ], + "children": [ + 32519, + 32522, + 32521, + 32524, + 32520, + 32523, + 32527, + 32518 + ], + "area": 1137100.6480679999, + "iscrowd": 0, + "segmentation": [], + "text": "CLASSIFICATION" + }, + { + "id": 32522, + "strid": "97e0631b-9a2b-450f-a128-db60dc188928", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1731.102, + 786.982, + 831.086, + 97.77499999999998 + ], + "priority": 12, + "parents": [ + 32516 + ], + "children": [], + "area": 1362346.114164, + "iscrowd": 0, + "segmentation": [], + "text": "Data\n\nTwo types of data were used for classification (Figure 3):" + }, + { + "id": 32518, + "strid": "067a7ff6-8803-4d2b-ad4f-f554341936e7", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1729.356, + 896.979, + 848.546, + 96.029 + ], + "priority": 13, + "parents": [ + 32516 + ], + "children": [], + "area": 1551196.0155240002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 32523, + "strid": "f4153b5a-bd93-4928-acf4-415fc8faf6d8", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1727.61, + 1012.213, + 914.8929999999998, + 40.156999999999925 + ], + "priority": 14, + "parents": [ + 32516 + ], + "children": [], + "area": 1748709.30093, + "iscrowd": 0, + "segmentation": [], + "text": "In addition, we used two methods for combining CBF and GM:" + }, + { + "id": 32519, + "strid": "d7c903bf-e6a6-4017-b4a4-ae24f5a0ef7f", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1731.102, + 1071.577, + 948.0669999999998, + 94.2829999999999 + ], + "priority": 15, + "parents": [ + 32516 + ], + "children": [], + "area": 1855009.087854, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 32524, + "strid": "1cf7e1dd-c4e7-434d-ae45-18bdf9a6d531", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2687.471, + 747.894, + 552.299, + 372.35699999999997 + ], + "priority": 16, + "parents": [ + 32516 + ], + "children": [ + 32525 + ], + "area": 2009943.436074, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 32525, + "strid": "138c4d87-25c2-4262-a172-cde30ff0377a", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2688.362, + 1130.94, + 468.56399999999985, + 38.305000000000064 + ], + "priority": 17, + "parents": [ + 32524 + ], + "children": [], + "area": 3040376.1202800004, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3. CBF map and GM segmentation" + }, + { + "id": 32521, + "strid": "98f0ec3b-5900-4909-9a25-535a03a8719c", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1729.356, + 1219.985, + 459.1919999999998, + 186.81999999999994 + ], + "priority": 18, + "parents": [ + 32516 + ], + "children": [], + "area": 2109788.3796599996, + "iscrowd": 0, + "segmentation": [], + "text": "Feature extraction\n\nTwo approaches for feature\nextraction were evaluated (Fig-\nure 4):" + }, + { + "id": 32520, + "strid": "c5dcf83e-5566-4461-b890-da2ad70d2d82", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1731.102, + 1422.518, + 461.42200000000025, + 478.962 + ], + "priority": 19, + "parents": [ + 32516 + ], + "children": [], + "area": 2462523.754836, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 32527, + "strid": "62b495c4-5f99-4118-870f-b644b058604c", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2202.753, + 1194.178, + 1038.54, + 697.3700000000001 + ], + "priority": 20, + "parents": [ + 32516 + ], + "children": [ + 32526 + ], + "area": 2630479.1720340005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 32526, + "strid": "d731e882-cf3f-4ebd-8aa4-5f4c0d057c77", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2202.994, + 1904.292, + 449.44299999999976, + 40.39899999999989 + ], + "priority": 21, + "parents": [ + 32527 + ], + "children": [], + "area": 4195143.850248, + "iscrowd": 0, + "segmentation": [], + "text": "Fgure 4. Six feature extraction methods" + }, + { + "id": 32532, + "strid": "40c8399a-2653-454a-803f-31598e69545d", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 82.37, + 1990.588, + 203.378, + 46.575000000000045 + ], + "priority": 22, + "parents": [ + 32558 + ], + "children": [ + 32538, + 32539, + 32535, + 32534 + ], + "area": 163964.73356, + "iscrowd": 0, + "segmentation": [], + "text": "RESULTS" + }, + { + "id": 32534, + "strid": "5be66622-7354-491e-8252-67a4da4fba4b", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 173.364, + 2158.0, + 1177.314, + 909.9389999999999 + ], + "priority": 23, + "parents": [ + 32532 + ], + "children": [ + 32537 + ], + "area": 374119.512, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 32537, + "strid": "2aff0495-c02b-4da0-a790-d5b23d6dc593", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 98.096, + 3108.153, + 1272.33, + 68.44799999999987 + ], + "priority": 24, + "parents": [ + 32534 + ], + "children": [], + "area": 304897.376688, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 5. Classification performances quantified by the area under the ROC-curve (AUC) determined using leave-\none-out (LOO) crossvalidation." + }, + { + "id": 32538, + "strid": "f9e9d7db-0a67-4d06-bb1e-a57da3b4bf5d", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 112.859, + 3194.049, + 1266.961, + 124.81700000000001 + ], + "priority": 25, + "parents": [ + 32532 + ], + "children": [], + "area": 360477.176091, + "iscrowd": 0, + "segmentation": [], + "text": "The highest classification performances were obtained with the voxel-wise approach\n(Figure 5). In this approach, CBF classifications performed similarly to GM. Combination\nof CBF & GM was slightly but not significantly better than GM only." + }, + { + "id": 32535, + "strid": "0918cbaf-6081-40fc-82d5-35666d07fa52", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1432.616, + 2145.062, + 1771.4539999999997, + 951.0900000000001 + ], + "priority": 26, + "parents": [ + 32532 + ], + "children": [ + 32536 + ], + "area": 3073050.1421919996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 32536, + "strid": "6e0255ea-d7bd-4aae-be44-5c8a65f27e21", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1431.589, + 3111.791, + 1769.375, + 61.554999999999836 + ], + "priority": 27, + "parents": [ + 32535 + ], + "children": [], + "area": 4454805.765899, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 6. P-maps for the voxel-wise classifications. Non-blue voxels are significantly different (p<0.05) between patient and control groups based on SVM clas-\nsification." + }, + { + "id": 32539, + "strid": "3b99d361-b501-4cb8-ac72-73d61e073210", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1440.216, + 3196.733, + 1763.545, + 127.5010000000002 + ], + "priority": 28, + "parents": [ + 32532 + ], + "children": [], + "area": 4603986.014328, + "iscrowd": 0, + "segmentation": [], + "text": "In the CBF voxel-wise p-maps (Figure 6A), several clusters of significantly different voxels were observed, located mainly in\nthe thalamus, amygdala, and anterior and posterior cingulate gyrus. For GM (Figure 6B), clusters of significantly different\nvoxels were seen in the hippocampus, insula, posterior cingulate gyrus and thalamus." + }, + { + "id": 32550, + "strid": "9e6af7c6-5e73-4b3f-9806-b90d80f26781", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 82.913, + 3433.789, + 434.765, + 46.19399999999996 + ], + "priority": 29, + "parents": [ + 32558 + ], + "children": [ + 32551, + 32557, + 32555, + 32552, + 32554, + 32556, + 32553 + ], + "area": 284705.747357, + "iscrowd": 0, + "segmentation": [], + "text": "IMPLEMENTATION" + }, + { + "id": 32551, + "strid": "bc1a6152-25d8-4a13-9a1d-ba846a69aa80", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 85.631, + 3546.556, + 1506.733, + 135.86400000000003 + ], + "priority": 30, + "parents": [ + 32550 + ], + "children": [], + "area": 303695.136836, + "iscrowd": 0, + "segmentation": [], + "text": "Participants: We recruited 32 presenile patients with established early-stage dementia, suspected of\neither AD or FTD (age: 62.8 + 4.1 yr, 17 male, Mini Mental State Examination (MMSE): 26.6 + 2.9). In ad-\n\ndition, 32 age-matched healthy controls were included (age: 62.0 + 4.4 yr, 18 male, MMSE: 29.0 + 1.0)." + }, + { + "id": 32552, + "strid": "f2f9c259-4fcb-49b0-a284-2ea00e7c9402", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 84.272, + 3705.517, + 1505.374, + 122.27799999999979 + ], + "priority": 31, + "parents": [ + 32550 + ], + "children": [], + "area": 312271.328624, + "iscrowd": 0, + "segmentation": [], + "text": "Image acquisition: T1-weighted (T1w) and pseudocontinuous ASL imaging were acquired on a 3T MR\nscanner (Discovery MR750, GE Healthcare). T1w resolution: 0.94x0.94x1 mm; 3D ASL was acquired with\nspiral read-out with an isotropic resolution of 3.3 mm, reconstructed resolution: 1.9x1.9x4 mm." + }, + { + "id": 32553, + "strid": "76c979ce-492c-4ddc-b48d-549ebf358965", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 88.348, + 3852.25, + 1423.856, + 51.628000000000156 + ], + "priority": 32, + "parents": [ + 32550 + ], + "children": [], + "area": 340338.583, + "iscrowd": 0, + "segmentation": [], + "text": "Tissue segmentations: Probabilistic tissue maps were obtained for WM, GM and CSF using SPM8." + }, + { + "id": 32554, + "strid": "8d52e971-0fbe-4d18-8b0d-322ae2d7b42f", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 81.555, + 3922.9, + 1513.526, + 78.80099999999993 + ], + "priority": 33, + "parents": [ + 32550 + ], + "children": [], + "area": 319932.1095, + "iscrowd": 0, + "segmentation": [], + "text": "ASL post-processing: ASL images were corrected for partial volume effects [5,6], CBF maps were quanti-\nfied and registered [7] to the subjects’ T1w images. In the analysis, only the CBF in GM was used." + }, + { + "id": 32555, + "strid": "31b3e439-0f8c-4d18-81b1-20b850aedb1f", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 86.989, + 4019.363, + 1493.146, + 88.31200000000035 + ], + "priority": 34, + "parents": [ + 32550 + ], + "children": [], + "area": 349640.368007, + "iscrowd": 0, + "segmentation": [], + "text": "Template space: For the voxel-wise classification, a template space was defined as the group mean of\nthe T1w images of all subjects. CBF maps and tissue maps were transformed to the template space." + }, + { + "id": 32556, + "strid": "c034835e-7916-4cd0-ab70-73081dfd42f8", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 84.272, + 4126.696, + 1498.581, + 82.87700000000041 + ], + "priority": 35, + "parents": [ + 32550 + ], + "children": [], + "area": 347764.92531200004, + "iscrowd": 0, + "segmentation": [], + "text": "ROI sets: A multi-atlas approach was used to construct five ROI sets for each subject using registration\nof 30 manually labeled images and label fusion with majority voting [8,9]." + }, + { + "id": 32557, + "strid": "5542b7fe-2da1-441b-bf7c-72405e32044b", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 85.631, + 4231.311, + 1505.374, + 47.55199999999968 + ], + "priority": 36, + "parents": [ + 32550 + ], + "children": [], + "area": 362331.39224099996, + "iscrowd": 0, + "segmentation": [], + "text": "Classification: A linear support vector machine [10] with LOO crossvalidation was used for classification." + }, + { + "id": 32542, + "strid": "99a97435-1889-4600-a8d2-5d3b2bb879e7", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1726.087, + 3430.262, + 311.37200000000007, + 52.34299999999985 + ], + "priority": 37, + "parents": [ + 32558 + ], + "children": [ + 32546, + 32540, + 32544, + 32547, + 32545, + 32543 + ], + "area": 5920930.644794, + "iscrowd": 0, + "segmentation": [], + "text": "DISCUSSION" + }, + { + "id": 32543, + "strid": "00c23f96-dff3-45ba-9582-d3ce3950afe5", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1730.113, + 3526.894, + 946.1939999999997, + 124.81700000000001 + ], + "priority": 38, + "parents": [ + 32542 + ], + "children": [], + "area": 6101925.159022, + "iscrowd": 0, + "segmentation": [], + "text": "High diagnostic performance: The voxel-wise classification meth-\nods resulted in an AUC of up to 91%, which can be considered\nhigh for this early-stage dementia patient population." + }, + { + "id": 32544, + "strid": "952e5e07-9870-4747-8de0-f882f191d09b", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1731.456, + 3694.659, + 948.8790000000001, + 212.05499999999984 + ], + "priority": 39, + "parents": [ + 32542 + ], + "children": [], + "area": 6397139.493504, + "iscrowd": 0, + "segmentation": [], + "text": "Added value of ASL: Although CBF was a good diagnostic marker\nby itself, our results showed no added value over atrophy mark-\ners based on structural MRI. The combination methods showed\na slight improvement in AUC, but this was not significant (McNe-\nmar test, p > 0.45)." + }, + { + "id": 32545, + "strid": "ef73d3b8-07f6-4dc2-9b7f-08c5cb59ccf2", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1731.456, + 3944.294, + 947.537, + 80.52700000000004 + ], + "priority": 40, + "parents": [ + 32542 + ], + "children": [], + "area": 6829371.512064, + "iscrowd": 0, + "segmentation": [], + "text": "Voxel vs ROI: The voxel-wise methods overall provided higher per-\nformance than the ROI-based techniques, which indicates that" + }, + { + "id": 32546, + "strid": "c9ad79af-465d-41be-a0bf-12f8684d39b9", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1730.113, + 4028.847, + 1504.5159999999998, + 126.1590000000001 + ], + "priority": 41, + "parents": [ + 32542 + ], + "children": [], + "area": 6970360.569711001, + "iscrowd": 0, + "segmentation": [], + "text": "important diagnostic information was lost by averaging over the ROls. The voxel-wise classifiers mainly\nrely on small clusters of voxels covering only a small part of the ROls (Figure 7). The used anatomical\nregion labeling was not optimal for the ROI-wise classifications." + }, + { + "id": 32547, + "strid": "99cba6b7-6de8-47c0-a765-f8cdc88203e0", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1730.113, + 4192.586, + 1497.8059999999998, + 85.89599999999973 + ], + "priority": 42, + "parents": [ + 32542 + ], + "children": [], + "area": 7253647.542218001, + "iscrowd": 0, + "segmentation": [], + "text": "P-maps: We found features significant for classification that largely corresponded to literature [11,12].\nGM significance maps were mostly symmetrical, whereas CBF p-maps were more asymmetrical." + }, + { + "id": 32540, + "strid": "3e74a4c6-eedf-4d07-8013-0dc6c26380cd", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2684.361, + 3518.842, + 562.348, + 322.1089999999999 + ], + "priority": 43, + "parents": [ + 32542 + ], + "children": [ + 32541 + ], + "area": 9445842.229962, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 32541, + "strid": "f7e9ac7d-9a61-4903-b5d2-43f4669db81b", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2685.703, + 3853.03, + 551.6109999999999, + 132.8699999999999 + ], + "priority": 44, + "parents": [ + 32540 + ], + "children": [], + "area": 10348094.23009, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 7. P-maps A) within the thalamus for CBF,\nand B) within the hippocampus for GM. These\ntwo regions showed the highest percentage of\nSignificant voxels." + }, + { + "id": 32549, + "strid": "9cb52d11-b73d-4e9f-a9d0-9c3adafc0d48", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 864.947, + 4387.283, + 165.48200000000008, + 33.422999999999774 + ], + "priority": 45, + "parents": [ + 32558 + ], + "children": [ + 32548 + ], + "area": 3794767.269001, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 32548, + "strid": "7059b269-995d-412b-8b9e-3b1b36a8563d", + "image_id": 201775, + "image_name": "117666.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 865.599, + 4438.979, + 2268.372, + 141.92699999999968 + ], + "priority": 46, + "parents": [ + 32549 + ], + "children": [], + "area": 3842375.7834210005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 162322, + "strid": "11ce998c-9fb8-42df-b5be-8608500ca8ac", + "image_id": 206835, + "image_name": "6511.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 341.5, + 17.55, + 77.22000000000003, + 50.290000000000006 + ], + "priority": -1, + "parents": [], + "children": [ + 162308, + 162306, + 162309, + 162307, + 162311, + 162312, + 162321, + 162310 + ], + "area": 5993.325, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 162306, + "strid": "abbf6138-d168-4d9c-b600-5668252e3224", + "image_id": 206835, + "image_name": "6511.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 313.394, + 133.249, + 448.727, + 29.004999999999995 + ], + "priority": 1, + "parents": [ + 162322 + ], + "children": [], + "area": 41759.437106, + "iscrowd": 0, + "segmentation": [], + "text": "Life Cycle of a Bioinformatics Workshop" + }, + { + "id": 162307, + "strid": "00c1ae55-b928-4bec-a27a-9ff97172c9de", + "image_id": 206835, + "image_name": "6511.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 377.745, + 187.289, + 335.178, + 47.208 + ], + "priority": 2, + "parents": [ + 162322 + ], + "children": [], + "area": 70747.483305, + "iscrowd": 0, + "segmentation": [], + "text": "Michelle D. Brazas and B. F. Francis Ouellette\nOntario Institute for Cancer Research, Toronto, Ontario, Canada\nSPR: SETS roy ery." + }, + { + "id": 162312, + "strid": "bde8a682-0ce2-42d4-b159-de7b74045ee6", + "image_id": 206835, + "image_name": "6511.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 76.792, + 280.749, + 685.521, + 67.87900000000002 + ], + "priority": 3, + "parents": [ + 162322 + ], + "children": [], + "area": 21559.277208000003, + "iscrowd": 0, + "segmentation": [], + "text": "Abstract\nWhy did he Blainformatcs Bofors Gomis and roteomcs warkshops dsppeas hom the seis? Wl there be afothcoming workshop in epigenetis x cea\ninforatis ver the past snten years of continuing educaton workshops in informatics, Sinfrmatcsca has seen the introduction andreliement of aumerous wakshops\nHere we explore what the dives ate othe intioducton of new workshops in bisformats and what the reasons ater ether the uatsformation or rerement ofa warishop.\nUnderstanding the actors that contibute othe Meee a beefs workshop lial fr continuing education programs ke Bonformales cto stay vale, up to date" + }, + { + "id": 162308, + "strid": "956bd542-9ca8-4e5f-8f38-c68967839bce", + "image_id": 206835, + "image_name": "6511.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 66.733, + 376.026, + 174.133, + 14.740999999999985 + ], + "priority": 4, + "parents": [ + 162322 + ], + "children": [ + 162314, + 162313 + ], + "area": 25093.343058000002, + "iscrowd": 0, + "segmentation": [], + "text": "INTRODUCTION of a Workshop" + }, + { + "id": 162313, + "strid": 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Sarah L Morgan, ao atid Sie i\n\nELIXIR Training Platform and EXCELERATE WP1 ean Xaes Lie" + }, + { + "id": 108707, + "strid": "016f9240-4b5c-4001-af0a-b88b8f513efa", + "image_id": 204717, + "image_name": "12892.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 47.848, + 750.955, + 2399.696, + 90.606 + ], + "priority": 3, + "parents": [ + 108726 + ], + "children": [ + 108725 + ], + "area": 35931.694840000004, + "iscrowd": 0, + "segmentation": [], + "text": "Objectives - Quality and Impact Subtask (EXCELERATE WP11.1.1) :" + }, + { + "id": 108725, + "strid": "18ecfcfd-e7bb-492a-939c-9e5fd5421e7c", + "image_id": 204717, + "image_name": "12892.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 42.099, + 851.628, + 3180.7, + 407.5090000000001 + ], + "priority": 4, + "parents": [ + 108707 + ], + "children": [], + "area": 35852.687172, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 108708, + "strid": "bbba4735-3d9e-4990-acbc-caea65ac97fb", + 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"2) Common feedback collection approach established and implemented\nFeedback data is collected systematically for ELIXIR-badged training events run at\neach ELIXIR Node, including events supported by EXCELERATE." + }, + { + "id": 108711, + "strid": "ac6554c9-e0f5-4bbe-a59a-261586ca8085", + "image_id": 204717, + "image_name": "12892.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 466.959, + 2800.53, + 1215.947, + 618.0349999999999 + ], + "priority": 10, + "parents": [ + 108708 + ], + "children": [ + 108714 + ], + "area": 1307732.68827, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 108714, + "strid": "619ec666-f372-4971-9d9f-35f4e061d090", + "image_id": 204717, + "image_name": "12892.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 49.808, + 2860.784, + 314.173, + 484.7890000000002 + ], + "priority": 11, + "parents": [ + 108711 + ], + "children": [], + "area": 142489.92947200002, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1:\nIndividuals travel\nfrom all over the\nworld to attend\nELIXIR-badged\ntraining events,\nas depicted by\nthe countries in\n‘green’." + }, + { + "id": 108723, + "strid": "f7c842fc-f142-418a-96f1-2b6d9f448ae0", + "image_id": 204717, + "image_name": "12892.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1885.72, + 1348.656, + 1328.24, + 453.4100000000001 + ], + "priority": 12, + "parents": [ + 108708 + ], + "children": [], + "area": 2543187.59232, + "iscrowd": 0, + "segmentation": [], + "text": "3) Feedback data captured since September 2016 show\npromising results\n\nShort Term Feedback — training quality\n\n11 participating ELIXIR Nodes (4-5 additional Nodes to provide data soon)\n264 training events surveyed\n\n4,086 short term feedback survey responses captured" + }, + { + "id": 108709, + "strid": "c28cbaeb-a2db-4aee-a0cd-21cb5a02f7b8", + "image_id": 204717, + "image_name": "12892.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1925.833, + 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"iscrowd": 0, + "segmentation": [], + "text": "“| would recommend the\ncourse to others”\n\n~ 87% of survey\nrespondents\n\n“| would use the\ntools/resources covered in\nthe course again” ~ 83%\nof survey respondents" + }, + { + "id": 108718, + "strid": "3435b88e-9261-419a-ad9a-20e494fccdf6", + "image_id": 204717, + "image_name": "12892.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1895.748, + 2554.376, + 832.4549999999999, + 50.09999999999991 + ], + "priority": 16, + "parents": [ + 108708 + ], + "children": [], + "area": 4842453.193248001, + "iscrowd": 0, + "segmentation": [], + "text": "Long Term Feedback — training impact" + }, + { + "id": 108719, + "strid": "0bee79de-2936-4040-ad84-bc7007cbde96", + "image_id": 204717, + "image_name": "12892.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1889.897, + 2614.495, + 453.2950000000001, + 753.4659999999999 + ], + "priority": 17, + "parents": [ + 108708 + ], + "children": [], + "area": 4941126.257014999, + "iscrowd": 0, + "segmentation": [], + "text": "4 participating Nodes\n24 training events\nsurveyed\n\n159 long term\nfeedback survey\nresponses captured\n\n“| have increased my\nusage of the tools/\nresources covered in\nthe course”\n\n~ 80% of survey\nrespondents" + }, + { + "id": 108710, + "strid": "b204eb80-4a4a-4264-ab9d-6002a2c8a1dc", + "image_id": 204717, + "image_name": "12892.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2418.957, + 2655.662, + 791.569, + 563.6730000000002 + ], + "priority": 18, + "parents": [ + 108708 + ], + "children": [ + 108716 + ], + "area": 6423932.184533999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 108716, + "strid": "5a385208-6fc6-4ba1-a517-bd43a536865c", + "image_id": 204717, + "image_name": "12892.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2400.327, + 3258.468, + 774.721, + 104.20100000000002 + ], + "priority": 19, + "parents": [ + 108710 + ], + "children": [], + 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The fre caused\nvarious degrees of damage tothe tree canopies trom\ntoll defoliation to almost no defoliation, depending on\ntheir topographic locations in the 86 ha catchment\n\nFortunately all monitoring equipment survived th fre\nand recorded all the envionmental and eap fo data\nover this unplanned event\n\nThis poster presents some results form the most\natfected site, which represents. of the study\no lchmant are." + }, + { + "id": 28387, + "strid": "c0f98f63-5e28-426e-8504-1423834ba0cf", + "image_id": 201619, + "image_name": "117406.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 546.037, + 199.746, + 277.783, + 221.79 + ], + "priority": 6, + "parents": [ + 28385 + ], + "children": [], + "area": 109068.706602, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 28394, + "strid": "1a3bb116-7370-4a5d-9f44-9c66bb7c4bca", + "image_id": 201619, + "image_name": "117406.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 369.149, + 443.302, + 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night-time sap flow." + }, + { + "id": 28389, + "strid": "4412d84f-bfcb-47fe-bc30-43d01f1514e9", + "image_id": 201619, + "image_name": "117406.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 583.123, + 444.805, + 207.24599999999998, + 138.16400000000004 + ], + "priority": 12, + "parents": [ + 28394 + ], + "children": [ + 28395 + ], + "area": 259376.02601500004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 28395, + "strid": "58e60cbd-8c7e-4111-88e5-e0d20a2f5b92", + "image_id": 201619, + "image_name": "117406.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 572.307, + 587.09, + 231.91599999999994, + 19.94500000000005 + ], + "priority": 13, + "parents": [ + 28389 + ], + "children": [], + "area": 335995.71663000004, + "iscrowd": 0, + "segmentation": [], + "text": "‘Figure 1 Diurnal changes of the hourly sap ux density showing\n‘Figure 1 Olurnad changes of he hourly sap Mux density showing" + }, + { + "id": 28391, + "strid": 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the vight\nmisture of ee species evolved and adapted to the local\nfie ragimes. The uilimate purpose ol his study i to\nprovide key knowledge tothe establishment ofa sol\nsustaining woodland on a rehabilatated mine site." + }, + { + "id": 38241, + "strid": "de5b81cb-5780-4f87-8a60-88c6333ca218", + "image_id": 202007, + "image_name": "117995.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 2378.81, + 134.5, + 296.5100000000002, + 287.53 + ], + "priority": -1, + "parents": [], + "children": [ + 38230, + 38228, + 38232, + 38231, + 38227, + 38229 + ], + "area": 319949.945, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 38227, + "strid": "6f0a2a4e-a3a3-4bc0-8140-5304e75149bd", + "image_id": 202007, + "image_name": "117995.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 143.748, + 267.755, + 1911.2439999999997, + 223.348 + ], + "priority": 1, + "parents": [ + 38241 + ], + "children": [], + "area": 38489.24574, + "iscrowd": 0, + "segmentation": [], + "text": "Challenges;involved in developing a\ndynamic.e-learning platformefor EMBL-EBI" + }, + { + "id": 38228, + "strid": "95bc5ecb-a13d-4743-b102-f1b7d06ddeb2", + "image_id": 202007, + "image_name": "117995.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 149.181, + 54.637, + 2153.028, + 114.549 + ], + "priority": 2, + "parents": [ + 38241 + ], + "children": [], + "area": 8150.802297000001, + "iscrowd": 0, + "segmentation": [], + "text": "Mindi Sehra’, Katrina Pavelin’’, Jospeh Rosetto', Thomas Laurent', Sarah Morgan', Cath Brooksbank'\n\n1 EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD" + }, + { + "id": 38231, + "strid": "1fed915e-3701-4dd0-9875-a8026714c174", + "image_id": 202007, + "image_name": "117995.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 141.649, + 812.357, + 2064.074, + 79.25199999999995 + ], + "priority": 3, + "parents": [ + 38241 + ], + "children": [ + 38233 + ], + "area": 115069.55669299999, + "iscrowd": 0, + "segmentation": [], + "text": "There is a growing need for e-Learning in the scientific community" + }, + { + "id": 38233, + "strid": "cf0d9035-cfae-4471-b19c-74507322f09d", + "image_id": 202007, + "image_name": "117995.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 146.153, + 953.195, + 3072.962, + 243.005 + ], + "priority": 4, + "parents": [ + 38231 + ], + "children": [], + "area": 139312.308835, + "iscrowd": 0, + "segmentation": [], + "text": "E-learning is playing an increasingly important role in the continuing professional development of life scientists. The main drivers are a desire\nto learn about new methodologies and resources in a way that fits around their daily schedule, and a need to reduce the costs associated with\n‘traditional’ training. Web-based resources can address these needs, with high-quality courses that provide researchers with effective ways to\ngain new skills and knowledge in their own time." + }, + { + "id": 38232, + "strid": "afbf0373-3641-4cc7-ac17-2da93b58f2cc", + "image_id": 202007, + "image_name": "117995.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 145.172, + 1275.541, + 1488.177, + 63.402000000000044 + ], + "priority": 5, + "parents": [ + 38241 + ], + "children": [ + 38234 + ], + "area": 185172.83805199998, + "iscrowd": 0, + "segmentation": [], + "text": "EMBL-EBI addresses this need with Train Online" + }, + { + "id": 38234, + "strid": "89b7b3dd-a21b-466a-ad8f-c69c2f76fb3f", + "image_id": 202007, + "image_name": "117995.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 144.0, + 1411.577, + 3078.548, + 184.80099999999993 + ], + "priority": 6, + "parents": [ + 38232 + ], + "children": [], + "area": 203267.088, + "iscrowd": 0, + "segmentation": [], + "text": "Train online (www.ebi.ac.uk/training/online) is a free web-based learning resource produced by EMBL-European Bioinformatics Institute. It\ncontains a range of courses, from quick tours and in-depth guides to EMBL-EBI resources, to video-based courses and general introductions to\na topic. Courses can easily be searched by theme (e.g. Genomics, Proteomics), knowledge level or duration." + }, + { + "id": 38229, + "strid": "473a67a8-927e-41e8-95e8-def475d87ab0", + "image_id": 202007, + "image_name": "117995.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 149.64, + 1695.467, + 2258.65, + 75.02199999999993 + ], + "priority": 7, + "parents": [ + 38241 + ], + "children": [ + 38237, + 38238, + 38239, + 38240 + ], + "area": 253709.68188, + "iscrowd": 0, + "segmentation": [], + "text": "The challenges of maintaining an e-learning resource — and our solutions" + }, + { + "id": 38237, + "strid": "6e6c9615-b5f3-4d7e-8665-a37d629e091a", + "image_id": 202007, + "image_name": "117995.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 148.242, + 1822.468, + 1525.682, + 599.1670000000001 + ], + "priority": 8, + "parents": [ + 38229 + ], + "children": [], + "area": 270166.301256, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 38239, + "strid": "2120a069-f45f-414f-820b-edff532c2455", + "image_id": 202007, + "image_name": "117995.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 163.463, + 2503.143, + 1564.074, + 974.9250000000002 + ], + "priority": 9, + "parents": [ + 38229 + ], + "children": [], + "area": 409171.264209, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 38238, + "strid": "adde12dd-43d0-45d0-9df8-5b0124603a34", + "image_id": 202007, + "image_name": "117995.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1801.111, + 1817.146, + 1420.7880000000002, + 1327.5870000000002 + ], + "priority": 10, + "parents": [ + 38229 + ], + "children": [], + "area": 3272881.649206, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 38240, + "strid": "3d70d283-9a67-4a6f-b28b-2b66e4a38469", + "image_id": 202007, + "image_name": "117995.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1863.529, + 3193.519, + 1332.96, + 283.6080000000002 + ], + "priority": 11, + "parents": [ + 38229 + ], + "children": [], + "area": 5951215.268550999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 38230, + "strid": "8345cc7b-3638-4597-b38c-f677f3abf0cd", + "image_id": 202007, + "image_name": "117995.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 148.245, + 3567.572, + 2712.527, + 77.52799999999979 + ], + "priority": 12, + "parents": [ + 38241 + ], + "children": [ + 38236, + 38235 + ], + "area": 528874.71114, + "iscrowd": 0, + "segmentation": [], + "text": "To create a dynamic platform requires a dynamic approach, identifying new challenges." + }, + { + "id": 38235, + "strid": "0a50a43c-dbef-4de1-8a16-a24cce17d59f", + "image_id": 202007, + "image_name": "117995.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 147.794, + 3697.96, + 3070.947, + 231.1909999999998 + ], + "priority": 13, + "parents": [ + 38230 + ], + "children": [], + "area": 546536.30024, + "iscrowd": 0, + "segmentation": [], + "text": "User experience testing\n\nWe are conducting user experience testing to gain direct opinions from our users and to see how they use train online. UX testing is an\nimportant component of web and service development across EMBL-EBI." + }, + { + "id": 38236, + "strid": "7762885b-eed3-4811-a420-e2c51fc5ac4e", + "image_id": 202007, + "image_name": "117995.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 146.391, + 3978.83, + 3073.541, + 294.09900000000016 + ], + "priority": 14, + "parents": [ + 38230 + ], + "children": [], + "area": 582464.90253, + "iscrowd": 0, + "segmentation": [], + "text": "Enhanced functionality\n\nWhilst the current system is widely used and provides a wealth of information, we are keen to make the courses more interactive and to\nencourage users to network. To achieve this, we plan to add more interactive exercises (with ‘live’ walk-throughs), moving screen shots and\ndiscussion boards. These measures should help elevate Train online to the dynamic platform we believe it can and should be." + }, + { + "id": 24647, + "strid": "dce7a2ab-41b9-492f-8736-3b58ac1db108", + "image_id": 201489, + "image_name": "117198.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 16.96, + 276.79, + 206.76999999999998, + 176.35999999999996 + ], + "priority": -1, + "parents": [], + "children": [ + 24626, + 24630, + 24628, + 24631, + 24625, + 24629, + 24644, + 24632, + 24627, + 24641 + ], + "area": 4694.358400000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 24625, + "strid": "4b2416f4-9c9d-4fff-ab91-ea04fea7e7e6", + "image_id": 201489, + "image_name": "117198.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 220.223, + 72.95, + 1551.94, + 125.83300000000001 + ], + "priority": 1, + "parents": [ + 24647 + ], + "children": [], + "area": 16065.267850000002, + "iscrowd": 0, + "segmentation": [], + "text": "Urinary chitinase 3-like 1, a novel biomarker for acute kidney injury\nin adult cardiac intensive care patients: a pilot study" + }, + { + "id": 24626, + "strid": "0c1df80c-c13d-4e63-8ec7-53da20c1b2f2", + "image_id": 201489, + "image_name": "117198.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 221.31, + 199.466, + 1579.829, + 194.76800000000003 + ], + "priority": 2, + "parents": [ + 24647 + ], + "children": [], + "area": 44143.82046, + "iscrowd": 0, + "segmentation": [], + "text": "Jorien De Loor’, Eric Hoste’, Ingrid Herck’, Katrien Francois’, Luc De Crop’, Charlotte Clauwaert’,\n\nKristel Demeyere’, and Evelyne Meyer’\n* Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium,\nJorien.DeLoor@UGent.be\n? Faculty of Medicine and Health Sciences, Ghent University, 9000 Gent, Belgium" + }, + { + "id": 24627, + "strid": "9f444363-41dd-4f3b-ba79-3cc5d12372f6", + "image_id": 201489, + "image_name": "117198.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 353.931, + 471.415, + 201.60600000000005, + 31.487000000000023 + ], + "priority": 3, + "parents": [ + 24647 + ], + "children": [ + 24633 + ], + "area": 166848.382365, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 24633, + "strid": "4cb6584c-9d83-49e9-867a-2c890f61ccfc", + "image_id": 201489, + "image_name": "117198.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 61.99, + 515.725, + 786.401, + 296.86199999999997 + ], + "priority": 4, + "parents": [ + 24627 + ], + "children": [], + "area": 31969.792750000004, + "iscrowd": 0, + "segmentation": [], + "text": "As much as 66% of human intensive care unit (ICU) patients develop\nacute kidney injury (AKI).2? In the majority of ICU patients, AKI is a\ncomplication of severe disease such as sepsis.* Importantly, both less\nsevere and severe AKI are independently associated with an\nincreased risk for worse outcomes.’Recent definition and staging\nsystems for AKI, although validated in numerous studies and over\n1.000.000 patients, recognize the limitations of both serum\ncreatinine (SCr) and urine output (UO) for the early detection and\naccurate estimation of AKI." + }, + { + "id": 24628, + "strid": "745692c1-9416-4b65-81b0-056cab26bf20", + "image_id": 201489, + "image_name": "117198.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1282.141, + 454.001, + 324.539, + 36.97300000000001 + ], + "priority": 5, + "parents": [ + 24647 + ], + "children": [ + 24634 + ], + "area": 582093.296141, + "iscrowd": 0, + "segmentation": [], + "text": "Aim and hypothesis" + }, + { + "id": 24634, + "strid": "ad27f616-437f-40a8-8bfc-82465fc20c37", + "image_id": 201489, + "image_name": "117198.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 894.686, + 499.531, + 1101.7529999999997, + 332.368 + ], + "priority": 6, + "parents": [ + 24628 + ], + "children": [], + "area": 446923.39226600004, + "iscrowd": 0, + "segmentation": [], + "text": "Our aim is to investigate the potential added value of urinary chitinase 3-like 1 (CHI3L1, YKL-40,\nBRP-39, cartilage glycoprotein 1, GP-39, HcGP-39) as a more early and specific diagnostic\nbiomarker for AKI in adult ICU patients that underwent elective cardiac surgery. The protein\nCHI3L1 was recently discovered in our group as a promising urinary AKI biomarker by shotgun\nproteomics in a novel in-house developed mouse sepsis model that reproducibly induces AKI.”°\nPreliminary clinical validation of the human orthologue protein in septic patients with and\nwithout AKI showed that urinary CHI3L1 (UCHI3L1) was markedly more excreted in human septic\npatients with than without AKI.°\n\nWe therefore hypothesize that UCHI3L1 is a superior biomarker for AKI in ICU patients than the\nroutinely used parameter SCr." + }, + { + "id": 24629, + "strid": "76a0cdbe-6cc2-4493-832a-84a7c8be6359", + "image_id": 201489, + "image_name": "117198.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 841.24, + 870.766, + 376.3399999999999, + 32.16399999999999 + ], + "priority": 7, + "parents": [ + 24647 + ], + "children": [ + 24635 + ], + "area": 732523.18984, + "iscrowd": 0, + "segmentation": [], + "text": "Materials and methods" + }, + { + "id": 24635, + "strid": "0194f59e-fd9c-49b9-a757-1a2c63507582", + "image_id": 201489, + "image_name": "117198.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 61.952, + 913.948, + 1934.448, + 232.22300000000007 + ], + "priority": 8, + "parents": [ + 24629 + ], + "children": [], + "area": 56620.906495999996, + "iscrowd": 0, + "segmentation": [], + "text": "The prospective single-center cohort study started in May 2012 in an academic cardiac surgery ICU. Blood and urine were collected preoperatively (baseline), at ICU\nadmission and at several time points until 48 hours (h) after ICU admission. Patients of age < 18 years were excluded, as well as patients with pre-existing AKI based on the\nKDIGO SCr and UO criteria, and patients with chronic kidney disease KDOQI stage 5 and/or with recent renal transplantation (< 3 months before cardiac surgery). For this\ninterim analysis, AKI was defined on KDIGO SCr criteria only. Baseline SCr was assessed as the SCr concentration measured before start of cardiac surgery. Urinary CHI3L1\nwas normalized to urinary creatinine (UCr). Data are expressed as median (interquartile range) and percentage (%).\n\nThe CHI3L1 level in serum and urine was determined with a commercially available research ELISA (DC3L10, R&D Systems), while both SCr and UCr were measured using\nthe kinetic Jaffé method (Cobas 8000, Roche, compensated)." + }, + { + "id": 24630, + "strid": "e652ac4b-890e-4c35-8571-b93f981bb880", + "image_id": 201489, + "image_name": "117198.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 968.609, + 1182.698, + 119.85900000000004, + 31.214999999999918 + ], + "priority": 9, + "parents": [ + 24647 + ], + "children": [ + 24645, + 24646, + 24638, + 24637, + 24636 + ], + "area": 1145571.927082, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 24636, + "strid": "d576c90a-e2ea-44ab-827b-94445849e117", + "image_id": 201489, + "image_name": "117198.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 60.145, + 1225.601, + 1938.542, + 302.5039999999999 + ], + "priority": 10, + "parents": [ + 24630 + ], + "children": [], + "area": 73713.77214500001, + "iscrowd": 0, + "segmentation": [], + "text": "Data for 33 patients (18 males, 15 females) were generated for interim analysis. Eleven patients (33 %), of which 7 females, developed AKI: 8 with AKI reaching KDIGO class\n1 (24%), 2 with AKI reaching KDIGO class 2 (6 %) and 1 with AKI reaching KDIGO class 3 (3 %). These 11 AKI patients were older compared to the non-AKI patients (80 y (68\n- 82) vs. 68 y (61 - 75; p = 0.026). The baseline SCr did not differ significantly between the AKI (0.86 mg/dL (0.77 -.1.15)) group and the non-AKI (0.89 mg/dL (0.77 - 1.00);\np = 0.462) group. Baseline serum CHI3L1 (SCHI3L1) was highly variable in both AKI and non-AKI patients. Moreover, no trend towards a higher SCHI3L1 level in AKI vs.\nnon-AKI patients was observed either at baseline or until AKI diagnosis by SCr. In contrast, the UCHI3L1/UCr ratio was higher in the AKI vs. non-AKI group at time points 0h\nand 6 h after admission to the ICU (1.86 ng/mg UCr (1.24 - 3.06) vs. 1.14 ng/mg UCr (0.86 - 1.88); p = 0.048, resp. 3.09 ng/mg UCr (1.17 - 5.55) vs. 1.28 ng/mg UCr (0.78 -\n2.05); p = 0.047). More importantly, this differential increase occurred before the diagnosis of AKI by SCr (24 h (16 - 40) after ICU admission). At time points. 2 h and 4h\nafter admission to the ICU, the UCHI3L1/UCr ratio was not significantly different between the AK! group and the non-AKI group although the same trend was observed\n(2.14 ng/mg UCr (1.39 - 2.68) vs. 1.15 ng/mg UCr (0.76 - 1.73); p = 0.058, resp. 2.08 ng/mg UCr (1.36 - 3.20) vs. 1.10 ng/mg UCr (0.83 - 2.10); p = 0.063)." + }, + { + "id": 24645, + "strid": "a4a4b616-edc8-4bfd-aac6-0ee70889f3a4", + "image_id": 201489, + "image_name": "117198.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 87.187, + 1551.735, + 836.691, + 831.0710000000001 + ], + "priority": 11, + "parents": [ + 24630 + ], + "children": [ + 24642 + ], + "area": 135291.119445, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 24642, + "strid": "51305745-d68c-4744-8c8a-5c8b72dfdc28", + "image_id": 201489, + "image_name": "117198.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 72.295, + 2416.574, + 867.49, + 97.14399999999978 + ], + "priority": 12, + "parents": [ + 24645 + ], + "children": [], + "area": 174706.21733, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1: Time patterns of normalized urinary chitinase 3-like 1 (UCHI3L1)\nand serum creatinine (SCr) in AKI vs. non-AKI patient that underwent\nelective cardiac surgery" + }, + { + "id": 24646, + "strid": "19cbd56a-7bc3-4e10-8c4f-40bc1311de30", + "image_id": 201489, + "image_name": "117198.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1041.193, + 1540.841, + 932.48, + 802.491 + ], + "priority": 13, + "parents": [ + 24630 + ], + "children": [ + 24643 + ], + "area": 1604312.863313, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 24643, + "strid": "a460cf0c-985c-4932-9c9c-e6eed6e3b651", + "image_id": 201489, + "image_name": "117198.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1020.372, + 2418.279, + 965.1139999999999, + 62.853000000000065 + ], + "priority": 14, + "parents": [ + 24646 + ], + "children": [], + "area": 2467544.179788, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2: Boxplots of normalized urinary chitinase 3-like 1 (UCHI3L1) in AKI vs. non-\nAKI group at different time points after elective cardiac surgery (n = 33)" + }, + { + "id": 24637, + "strid": "1bd8c4e0-6877-4127-89be-7e440a2766b0", + "image_id": 201489, + "image_name": "117198.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 71.594, + 2516.651, + 868.133, + 132.76400000000012 + ], + "priority": 15, + "parents": [ + 24630 + ], + "children": [], + "area": 180177.11169399996, + "iscrowd": 0, + "segmentation": [], + "text": "The asterisk denotes the detection of AKI by SCr at 35 hours (h) after\nadmission to the ICU. In contrast, UCHI3L1 (ng/mg UCr) is higher in the AKI\nvs. non-AKI patient already at admission to the ICU. Notice that the\nUCHI3L1/UCr ratio does not rise above 2 ng/mg in the non-AKI patient." + }, + { + "id": 24638, + "strid": "e947e9f1-268f-4e98-91cc-1d30f91176f3", + "image_id": 201489, + "image_name": "117198.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1020.698, + 2484.907, + 964.7769999999999, + 169.57799999999997 + ], + "priority": 16, + "parents": [ + 24630 + ], + "children": [], + "area": 2536339.605086, + "iscrowd": 0, + "segmentation": [], + "text": "Preoperatively, the UCHI3L1/UCr ratio shows no difference between the AKI vs.\nnon-AKI group. At admission to the ICU, UCHI3L1 (ng/mg UCr) is already significantly\nhigher in the AKI vs. non-AKI group (p = 0.048). Interestingly, in the following hours\nUCHI3L1 levels do not significantly differentiate both groups. Nevertheless, at 6 h\nafter admission to the ICU the difference becomes significant again (p = 0.047)." + }, + { + "id": 24632, + "strid": "72d26904-ee73-4cc0-a9ae-c163c20487fe", + "image_id": 201489, + "image_name": "117198.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 942.928, + 2691.998, + 169.51699999999994, + 31.978000000000065 + ], + "priority": 17, + "parents": [ + 24647 + ], + "children": [ + 24639 + ], + "area": 2538360.290144, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion" + }, + { + "id": 24639, + "strid": "7aafe409-3273-426f-b658-57b7f15c5c53", + "image_id": 201489, + "image_name": "117198.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 59.824, + 2732.972, + 1938.304, + 371.96399999999994 + ], + "priority": 18, + "parents": [ + 24632 + ], + "children": [], + "area": 163497.31692800001, + "iscrowd": 0, + "segmentation": [], + "text": "The production of CHI3L1 by different cell types such as macrophages is induced by type 2 cytokines such as IL-13 at sites of adaptive T helper 2 (Th2) inflammation. In\nturn, CHI3L1 reduces apoptosis of macrophages, alternatively activates them (M2 phenotype) and increases the recruitment of dendritic cells, leading to Th2\ndifferentiation of naive T cells. Moreover, CHI3L1 reduces apoptosis of Th2 cells and contributes to tissue healing/remodeling/fibrosis through a CHI3L1-dependent\ninduction and activation of transforming growth factor Bi (TGF- B.) by 1L-13.° The prevention of apoptosis by CHI3L1 in immune cells®, and as recently described also in\ncultured mouse proximal tubular cells’, involves activation of different pathways. In vitro analysis of isolated primary culture renal tubular cells confirmed that CHI3L1\ninhibits oxidant-induced apoptosis’ in accordance with the previous finding that CHI3L1 inhibits oxidant-induced lung injury.®\n\nOur group proposed CHI3L1 as a promising urinary biomarker for early and specific diagnosis of sepsis-induced AKI.° Another more recent urine proteomic screen in mice\nfound CHI3L1 to be a critical component of the repair process after bilateral renal injury/reperfusion (I/R). Moreover, the latter group showed that UCHI3L1 levels predict\npost-transplant AKI and need for renal replacement therapy in human patients undergoing deceased-donor kidney transplantation.”\n\nTogether with the current findings, these data suggest a role for CHI3L1 as an early sensor of the degree of kidney injury, a critical mediator of the repair process and a\npredictive parameter of chronic injury to the kidney." + }, + { + "id": 24631, + "strid": "909657ee-df5c-410b-9838-d7ac0147db57", + "image_id": 201489, + "image_name": "117198.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 938.666, + 3134.644, + 179.918, + 33.19300000000021 + ], + "priority": 19, + "parents": [ + 24647 + ], + "children": [ + 24640 + ], + "area": 2942383.744904, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion" + }, + { + "id": 24640, + "strid": "888803ec-e36a-4046-a721-b4dc0ba9dfa8", + "image_id": 201489, + "image_name": "117198.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 62.436, + 3178.197, + 1934.373, + 64.25700000000006 + ], + "priority": 20, + "parents": [ + 24631 + ], + "children": [], + "area": 198433.90789200002, + "iscrowd": 0, + "segmentation": [], + "text": "This interim analysis of an ongoing pilot study, with 300 ICU patients in 3 cohorts (general ICU, pediatric and adult cardiac surgery ICU), shows promising results for\nUCHI3L1 as an early diagnostic biomarker for AKI in adult !CU patients that undergo elective cardiac surgery, while the prognostic role remains to be investigated." + }, + { + "id": 24641, + "strid": "74de34a6-bc10-4950-841c-39625bd73868", + "image_id": 201489, + "image_name": "117198.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 62.193, + 3272.53, + 1938.504, + 85.51899999999978 + ], + "priority": 21, + "parents": [ + 24647 + ], + "children": [], + "area": 203528.45829, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgments\n\nThis work was supported by the Fonds voor Wetenschappelijk Onderzoek (FWO Aspirant grant to De Loor J.) and the Industrieel Onderzoeksfonds of the University of Ghent (IOF Advanced grant). We acknowledge\nsupport from Bimetra - Clinical Research Center Ghent, and from UGent TechTransfer. A patent application was filed on April 4, 2011; patent reference: EP11160965;" + }, + { + "id": 24644, + "strid": "b762d21f-626c-46b6-846a-2165fec2e3a1", + "image_id": 201489, + "image_name": "117198.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 61.478, + 3362.589, + 1865.137, + 242.4369999999999 + ], + "priority": 22, + "parents": [ + 24647 + ], + "children": [], + "area": 206725.246542, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 5386, + "strid": "86f8ab48-85b0-4024-aced-375cac60fc0a", + "image_id": 200719, + "image_name": "10655.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 65.31, + 61.17, + 244.49, + 220.03999999999996 + ], + "priority": -1, + "parents": [], + "children": [ + 5360, + 5373, + 5371, + 5368, + 5361, + 5369, + 5370, + 5372 + ], + "area": 3995.0127, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 5360, + "strid": "6d664a28-17a9-49a8-9590-bfe1c5241a13", + "image_id": 200719, + "image_name": "10655.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 563.369, + 98.581, + 2275.566, + 88.509 + ], + "priority": 1, + "parents": [ + 5386 + ], + "children": [], + "area": 55537.47938900001, + "iscrowd": 0, + "segmentation": [], + "text": "ls Oxford Nanopore Technology Ready for Clinical Diagnostics?" + }, + { + "id": 5361, + "strid": "226f70b3-7bb9-491c-840a-8b25b0d42dc7", + "image_id": 200719, + "image_name": "10655.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 916.662, + 197.456, + 1567.5400000000002, + 138.547 + ], + "priority": 2, + "parents": [ + 5386 + ], + "children": [], + "area": 181000.411872, + "iscrowd": 0, + "segmentation": [], + "text": "GR Taylor, Kesia Brown, Andrew Bond & Michael Yau\nViapath Clinical Genetics Labs, Guy’s Hospital, London UK" + }, + { + "id": 5370, + "strid": "ea178d2b-4809-420e-9436-27a47e6d95ad", + "image_id": 200719, + "image_name": "10655.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 81.79, + 482.665, + 237.42699999999996, + 49.541 + ], + "priority": 3, + "parents": [ + 5386 + ], + "children": [ + 5362 + ], + "area": 39477.17035000001, + "iscrowd": 0, + "segmentation": [], + "text": "Background" + }, + { + "id": 5362, + "strid": "acaa6f2e-29b5-46d9-a8b5-059c625e765a", + "image_id": 200719, + "image_name": "10655.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 75.358, + 545.064, + 1482.146, + 895.5950000000001 + ], + "priority": 4, + "parents": [ + 5370 + ], + "children": [], + "area": 41074.932912, + "iscrowd": 0, + "segmentation": [], + "text": "Bridging the “valley of death” between scientific and technological\ninnovation and clinical implementation is a cultural challenge for many\norganizations, including the NHS. Nanopore sequencing is a good\nexample of a potentially disruptive genomics technology that looks likely\nto converge with mainstream clinical genomics in the near future. Since\nthe technology is packaged in a range of products from the relatively\nsmall scale (Gigabase) O.N. Minion to the Terabase-scale Promethion,\nservice developers have the opportunity to cross the valley of death\nusing a “rope bridge” prior to investing in major infrastructure.\n\nOur objective is to validate diagnostic services using Oxford Nanopore’s\nMinion in the first instance and to evaluate the cost and performance\ncompared to existing sequencing technology in areas such as tumour\nDNA sequencing (and circulating tumour DNA), virology, microbiology,\ngenetics and HLA-typing. To facilitate this we are developing R&D\ncollaborations and securing grant funding and commercial backing." + }, + { + "id": 5371, + "strid": "e986e5a9-7997-49d9-bd16-8a4c3ebccd79", + "image_id": 200719, + "image_name": "10655.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 78.313, + 1486.538, + 184.824, + 43.791999999999916 + ], + "priority": 5, + "parents": [ + 5386 + ], + "children": [ + 5363, + 5385 + ], + "area": 116415.250394, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 5363, + "strid": "0e28d51a-ea3a-4613-b900-d3dca4058d00", + "image_id": 200719, + "image_name": "10655.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 72.528, + 1546.1, + 1489.75, + 1253.518 + ], + "priority": 6, + "parents": [ + 5371 + ], + "children": [], + "area": 112135.5408, + "iscrowd": 0, + "segmentation": [], + "text": "The scale of the Minion enables direct access to small genomes, but for\nGigabase genomes, enrichment in required to target the sequencing\ncapacity to the region of interest. In the studies reported here we used\nlong PCR to generate fragments in the range 3.5 to 16 Kb. Barcode and\nsequencing adapters were added by ligation. Targets were the HLA-B\nlocus, BRCA1, BRCA2, SMN1 and LDLR. The reads (2D and 1D) were\ncalled locally and converted to fastq using Poretools (Loman et al.).\nBarcode sorting used EPI2Z2ME. Fastq read length was measured using\nAWK; cat bc12.fastq | awk '{if(NR9%64==2) print length($1)}! | sort -n | uniq -c > bc12_length.txt\n\nand plotted using R:\nreads<-read.csv(file=\"bc12_length.txt\", sep=\"\", header=FALSE)\nplot (reads$V2,reads$V1,type=\"I\",xlab=\"bc12 (bases)\",ylab=\"occurences\",col=\"blue\", xlim=c(0,18000), ylim=c(0,100))\n\nRead mapping used either BWA, BLAT or GraphSeq. We selected a\ngenomic region including BRAF and and aligned reads of length 200\nbases to 200 kilobases with simulated error rates of phred 10 to phred\n40 to hg19 using GraphSeq, BLAT and BWA. FASTA files of length 200kbp\nto 200bp were generated from hg19 using samtools faidx, with starting\npositions of chr7: 140431813 (BRAF). We simulated error rates the\nrange phred 10 to phred 40 and examined the effect of error rate and\nread length on the ability to identify a point mutation.\n\nSamples\n\nThis presentation reports a series of BRCA1 and BRCA2 cases:" + }, + { + "id": 5385, + "strid": "4b07584a-0c0d-4fc6-81a4-1d7139110211", + "image_id": 200719, + "image_name": "10655.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 72.167, + 2820.603, + 1472.992, + 821.5889999999999 + ], + "priority": 7, + "parents": [ + 5371 + ], + "children": [], + "area": 203554.45670100002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 5372, + "strid": "27355da5-b45a-48af-884b-38621a624481", + "image_id": 200719, + "image_name": "10655.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 79.014, + 3734.909, + 418.325, + 53.32999999999993 + ], + "priority": 8, + "parents": [ + 5386 + ], + "children": [ + 5364, + 5375 + ], + "area": 295110.099726, + "iscrowd": 0, + "segmentation": [], + "text": "Sequenced products" + }, + { + "id": 5364, + "strid": "1486f9dc-0532-4118-89ad-cb89deb0bf07", + "image_id": 200719, + "image_name": "10655.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 76.785, + 3795.622, + 1476.98, + 240.48799999999983 + ], + "priority": 9, + "parents": [ + 5372 + ], + "children": [], + "area": 291446.83527, + "iscrowd": 0, + "segmentation": [], + "text": "The product size distribution for the BRCA1 and BRCA2 series was as\nexpected, with some small products also sequenced. Most products\nwere unique is length and in content, indicating that sequencing errors\nare common." + }, + { + "id": 5375, + "strid": "72e9b0df-4897-459b-bb63-1ec181f8674d", + "image_id": 200719, + "image_name": "10655.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 61.549, + 4128.328, + 1488.7, + 345.35199999999986 + ], + "priority": 10, + "parents": [ + 5372 + ], + "children": [ + 5384 + ], + "area": 254094.46007200002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 5384, + "strid": "301f144d-126d-4bf5-b320-bec5a99caf9a", + "image_id": 200719, + "image_name": "10655.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 271.055, + 4537.171, + 1063.765, + 82.6890000000003 + ], + "priority": 11, + "parents": [ + 5375 + ], + "children": [], + "area": 1229822.885405, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1\nRead length: pooled BRCA1 & BRCA2 (green) BRCA2 (blue) and BRCA1 (purple)" + }, + { + "id": 5368, + "strid": "4463e121-9502-42f2-9433-c025325b2624", + "image_id": 200719, + "image_name": "10655.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1685.395, + 462.73, + 453.3960000000002, + 48.488999999999976 + ], + "priority": 12, + "parents": [ + 5386 + ], + "children": [ + 5379, + 5367 + ], + "area": 779882.82835, + "iscrowd": 0, + "segmentation": [], + "text": "Results: read mapping" + }, + { + "id": 5367, + "strid": "ef6e4ace-5ef9-4db7-bcd1-d4e447499d77", + "image_id": 200719, + "image_name": "10655.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1680.006, + 521.422, + 1482.689, + 296.48199999999997 + ], + "priority": 13, + "parents": [ + 5368 + ], + "children": [], + "area": 875992.0885320001, + "iscrowd": 0, + "segmentation": [], + "text": "Each tool successfully mapped synthetic reads with error rates of up to\n10%, but the genomic indexes used by GraphMap were rather large, and\nso in further studies we used BWA or BLAT. Using the mpileup consensus\noption it was possible to call the variants in NA12878 correctly with no\nfalse positives using read depths of 500 with 2D reads (figure 2)" + }, + { + "id": 5379, + "strid": "a1aa9ea5-55de-4df4-9d81-e648e7ca0a50", + "image_id": 200719, + "image_name": "10655.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1679.745, + 876.352, + 1619.821, + 151.3470000000001 + ], + "priority": 14, + "parents": [ + 5368 + ], + "children": [ + 5380 + ], + "area": 1472047.8902399999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 5380, + "strid": "a3075844-6d91-48b0-bcbf-08605e785fb8", + "image_id": 200719, + "image_name": "10655.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2014.286, + 1045.229, + 914.509, + 78.88699999999994 + ], + "priority": 15, + "parents": [ + 5379 + ], + "children": [], + "area": 2105390.1414940003, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2\nHigh sensitivity and specificty achieved using mpileup re-alignmant" + }, + { + "id": 5369, + "strid": "1bdf6831-142f-4a51-b4eb-a141b126a83e", + "image_id": 200719, + "image_name": "10655.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1733.304, + 1139.611, + 456.797, + 50.30799999999999 + ], + "priority": 16, + "parents": [ + 5386 + ], + "children": [ + 5378, + 5376, + 5377, + 5366 + ], + "area": 1975292.3047440003, + "iscrowd": 0, + "segmentation": [], + "text": "Results: variant calling" + }, + { + "id": 5366, + "strid": "de2305ff-113f-4335-a620-57429f430fbd", + "image_id": 200719, + "image_name": "10655.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1725.876, + 1201.329, + 1494.28, + 409.05399999999986 + ], + "priority": 17, + "parents": [ + 5369 + ], + "children": [], + "area": 2073344.889204, + "iscrowd": 0, + "segmentation": [], + "text": "Variant identification protocols are in development: in a small control\nseries using 1D reads there is evidence or recurrent false postives\ncaused by insertions or deletions being reported non-randomly. We are\nable to identify true positives, but although the accuracy of 1D reads is\nof the order of 95%, the errors appear to be less random that seen with\n2D reads, and so consensus reads are not able to remove all of the\nerrors." + }, + { + "id": 5378, + "strid": "c47ca8dd-8a7f-46a0-9c20-1d239c53223f", + "image_id": 200719, + "image_name": "10655.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1672.95, + 1620.976, + 1592.6410000000003, + 760.3960000000002 + ], + "priority": 18, + "parents": [ + 5369 + ], + "children": [ + 5383 + ], + "area": 2711811.7992000002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 5383, + "strid": "4596f36b-0cd9-414d-844c-fa9526247570", + "image_id": 200719, + "image_name": "10655.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2102.535, + 2416.536, + 701.8670000000002, + 76.60500000000002 + ], + "priority": 19, + "parents": [ + 5378 + ], + "children": [], + "area": 5080851.518759999, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3\nVisualisation of the E1493fs variant in a BRCA2 case" + }, + { + "id": 5376, + "strid": "90123e5b-da2b-4f22-8e54-14d510c99e66", + "image_id": 200719, + "image_name": "10655.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1664.967, + 2529.061, + 1588.65, + 467.0149999999999 + ], + "priority": 20, + "parents": [ + 5369 + ], + "children": [ + 5382 + ], + "area": 4210803.105987, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 5382, + "strid": "95922540-e341-4c7c-9615-567c8b04b29b", + "image_id": 200719, + "image_name": "10655.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2280.59, + 3008.672, + 391.3069999999998, + 80.7460000000001 + ], + "priority": 21, + "parents": [ + 5376 + ], + "children": [], + "area": 6861547.2764800005, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 4\nExon 13-14 deletion in LDLR" + }, + { + "id": 5377, + "strid": "450ac8dc-a815-4338-b3e2-f1ca08d5af6d", + "image_id": 200719, + "image_name": "10655.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1672.95, + 3099.857, + 1572.6829999999998, + 467.0149999999999 + ], + "priority": 22, + "parents": [ + 5369 + ], + "children": [ + 5381 + ], + "area": 5185905.76815, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 5381, + "strid": "69e976a1-7ac8-4e16-b4ab-cc2135db5a06", + "image_id": 200719, + "image_name": "10655.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2313.716, + 3617.371, + 318.183, + 71.83800000000019 + ], + "priority": 23, + "parents": [ + 5377 + ], + "children": [], + "area": 8369569.160635999, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 5\nExon 7 deletion in LDLR" + }, + { + "id": 5373, + "strid": "20921e88-e0c8-4b03-99dd-31322429ac1d", + "image_id": 200719, + "image_name": "10655.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1768.924, + 3734.546, + 1028.118, + 52.21399999999994 + ], + "priority": 24, + "parents": [ + 5386 + ], + "children": [ + 5365, + 5374 + ], + "area": 6606128.048504, + "iscrowd": 0, + "segmentation": [], + "text": "Results: improving Q-scores using consensus reads" + }, + { + "id": 5374, + "strid": "23d9e575-7c0e-4b8e-9392-7fabbdab6096", + "image_id": 200719, + "image_name": "10655.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1716.554, + 3812.147, + 1462.212, + 514.0039999999999 + ], + "priority": 25, + "parents": [ + 5373 + ], + "children": [], + "area": 6543756.181438, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 5365, + "strid": "c4f9910b-6ebf-4090-8acd-181fcc5fc537", + "image_id": 200719, + "image_name": "10655.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1747.433, + 4414.932, + 1485.493, + 234.10300000000007 + ], + "priority": 26, + "parents": [ + 5373 + ], + "children": [], + "area": 7714797.8695559995, + "iscrowd": 0, + "segmentation": [], + "text": "In conclusion, random error rates are tractable by either consensus\nalignment and oversequencing. Provided systematic errors can be\navoided, as with 2D sequencing, nanopore sequencing can deliver\nunique tools for clinical use and point of care testing." + }, + { + "id": 140500, + "strid": "0d15a846-e00b-4235-9d3c-88305d0830b2", + "image_id": 205962, + "image_name": "16825.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 969.8, + 60.11, + 285.18000000000006, + 180.12 + ], + "priority": -1, + "parents": [], + "children": [ + 140479, + 140483, + 140478, + 140484, + 140476, + 140475, + 140477, + 140481, + 140482, + 140480 + ], + "area": 58294.678, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 140475, + "strid": "1bb2681f-6d3a-4f34-b4e4-c3fa7f0cf2c8", + "image_id": 205962, + "image_name": "16825.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 110.847, + 343.614, + 3025.083, + 211.48499999999996 + ], + "priority": 1, + "parents": [ + 140500 + ], + "children": [], + "area": 38088.581057999996, + "iscrowd": 0, + "segmentation": [], + "text": "Staff Education to Accelerate Cloud Adoption\n\nTraining EBI staff in cloud technologies" + }, + { + "id": 140476, + "strid": "dbb44b6f-aa5d-459b-9833-73c7019344d8", + "image_id": 205962, + "image_name": "16825.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 112.819, + 93.161, + 729.668, + 212.98399999999998 + ], + "priority": 2, + "parents": [ + 140500 + ], + "children": [], + "area": 10510.330859, + "iscrowd": 0, + "segmentation": [], + "text": "CD Tiwari, David Yu Yuan & Tony Wildish\n\nCloud Consultants\nEuropean Bioinformatics Institute, EMBL\n\nwildish@ebi.ac.uk" + }, + { + "id": 140477, + "strid": "cb64b6fd-0827-4537-8c23-dd2cc50dba3e", + "image_id": 205962, + "image_name": "16825.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 110.941, + 705.811, + 422.697, + 57.47500000000002 + ], + "priority": 3, + "parents": [ + 140500 + ], + "children": [ + 140485, + 140486, + 140497 + ], + "area": 78303.37815100001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 140485, + "strid": "2243e385-bcd4-4722-8879-9a6fb68064f6", + "image_id": 205962, + "image_name": "16825.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 101.292, + 806.886, + 522.729, + 433.0920000000001 + ], + "priority": 4, + "parents": [ + 140477 + ], + "children": [], + "area": 81731.096712, + "iscrowd": 0, + "segmentation": [], + "text": "The volume of data at EBI is\ndoubling every two years. In-\nhouse computing resources will\nnot be able to cope with this\ngrowth much longer, so we have a\nstrong motive to move some of our\ncomputing workloads to the cloud,\neither commercial clouds such as\nAWS and GCP or _ research\ninfrastructure clouds such as\nEOSC." + }, + { + "id": 140486, + "strid": "44f43e4d-12f6-4709-b23d-13f81382aea8", + "image_id": 205962, + "image_name": "16825.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 97.438, + 1257.738, + 1224.814, + 76.596 + ], + "priority": 5, + "parents": [ + 140477 + ], + "children": [], + "area": 122551.47524400002, + "iscrowd": 0, + "segmentation": [], + "text": "To promote awareness of the potential of cloud computing, the EBI Cloud\nConsultants have prepared a training course covering some of the basics." + }, + { + "id": 140497, + "strid": "fc0e9a74-6d74-4f25-ba8d-fed97a5c6b23", + "image_id": 205962, + "image_name": "16825.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 660.528, + 832.083, + 630.413, + 385.706 + ], + "priority": 6, + "parents": [ + 140477 + ], + "children": [], + "area": 549614.119824, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 140478, + "strid": "0a5751d0-1fb2-473d-91ea-6f550a86a686", + "image_id": 205962, + "image_name": "16825.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 114.775, + 1400.873, + 856.536, + 74.38499999999999 + ], + "priority": 7, + "parents": [ + 140500 + ], + "children": [ + 140487 + ], + "area": 160785.19857500002, + "iscrowd": 0, + "segmentation": [], + "text": "‘ResOps’ training course" + }, + { + "id": 140487, + "strid": "b5f491ab-5a83-44d2-91ec-de6c1b12d164", + "image_id": 205962, + "image_name": "16825.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 79.219, + 1515.285, + 1246.496, + 519.6119999999999 + ], + "priority": 8, + "parents": [ + 140478 + ], + "children": [], + "area": 120039.362415, + "iscrowd": 0, + "segmentation": [], + "text": "ResOps = ‘Research Operations’, similar to the wider-known term of ‘DevOps’, for\n‘Development Operations’, but focussed on the needs of researchers.\n\nMost researchers think DevOps is something that only silicon valley startups use,\nand don’t realise that in fact there’s nothing special about their software, and that\nthey can use the same techniques as everyone else.\n\nAccordingly, the ResOps training course was developed, tailored to EBI by the\nchoice of examples and exercises, more than the choice of tools and technology.\nUsing examples drawn from bioinformatics pipelines and services running at EBI\nputs the student on familiar ground, though the course as it stands could be given\nequally to scientists from any domain, or even to some of those silicon valley\nstartups!" + }, + { + "id": 140479, + "strid": "e62477f9-4741-498b-81ff-074f01513678", + "image_id": 205962, + "image_name": "16825.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 113.421, + 2094.727, + 501.013, + 73.06399999999985 + ], + "priority": 9, + "parents": [ + 140500 + ], + "children": [ + 140488 + ], + "area": 237586.031067, + "iscrowd": 0, + "segmentation": [], + "text": "Course design" + }, + { + "id": 140488, + "strid": "85a2c277-a011-4b85-87b6-3229ade3dfb9", + "image_id": 205962, + "image_name": "16825.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 73.488, + 2182.948, + 1246.496, + 599.846 + ], + "priority": 10, + "parents": [ + 140479 + ], + "children": [], + "area": 160420.482624, + "iscrowd": 0, + "segmentation": [], + "text": "The ResOps course was designed as a 1-day standalone course that could also be\ntaken completely offline, without the need for a classroom and a lecturer.\n\nAll the material is maintained in a GIT repository (https://bit.ly/resops-external),\nincluding the Powerpoint slides and the exercises, along with the rest of the\ndocumentation that the Cloud Consultants maintain for all aspects of cloud-related\nwork at EBI. Users can clone the repository and work with it offline, on their laptops,\nand they can pull from the master repository periodically, to get any updates that\nmight be made.\n\nExtensive hands-on exercises are provided, far more than can be covered in a 1-\nday classroom session, so the student can get an in-depth understanding of the\nmaterial by following through on them after the course. Having practical, working\nexamples makes the material far more accessible, and provides a good starting\npoint for incorporation into their own projects." + }, + { + "id": 140480, + "strid": "c7f59e82-ef55-4010-be7b-12fa2ede2ae8", + "image_id": 205962, + "image_name": "16825.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1417.121, + 705.043, + 739.4580000000001, + 71.87900000000002 + ], + "priority": 11, + "parents": [ + 140500 + ], + "children": [ + 140490, + 140489, + 140498 + ], + "area": 999131.2412030001, + "iscrowd": 0, + "segmentation": [], + "text": "Delivering the course" + }, + { + "id": 140489, + "strid": "7911e12a-c4d4-4331-a089-961943e4be9b", + "image_id": 205962, + "image_name": "16825.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1381.069, + 816.192, + 1246.2689999999998, + 714.1030000000001 + ], + "priority": 12, + "parents": [ + 140480 + ], + "children": [], + "area": 1127217.469248, + "iscrowd": 0, + "segmentation": [], + "text": "We ran the course first with a group of volunteers, some of whom were familiar with\nthe subject matter, some not. This allowed us to gauge the quality of the material\nand the pace of delivery, and helped us spot problems like undefined terms, forward\nreferences, and other minor inconsistencies.\n\nThe first iteration of the course included Terraform, Docker, Gitlab and Kubernetes.\nWe found that most of the audience were not interested in Terraform anymore,\nwhereas 3 years previously there had been strong interest in it. Now, it seems\npeople have realised that Kubernetes is the new platform, and that by architecting\nan application for Kubernetes, they can exploit cloud-specific Kubernetes\ninfrastructures in a portable and maintainable manner.\n\nThe initial feedback we got from this dry run was clear, we had far too much\nmaterial in the course — enough for about 3 days worth of training! Choosing what to\neliminate was difficult, even after dropping the Terraform component. Eventually, we\nsettled on the following topics for the course:" + }, + { + "id": 140498, + "strid": "11a306f3-9e3d-41b8-a157-6f46e875cda8", + "image_id": 205962, + "image_name": "16825.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1385.995, + 1533.064, + 470.16200000000003, + 271.3120000000001 + ], + "priority": 13, + "parents": [ + 140480 + ], + "children": [], + "area": 2124819.0386799998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 140490, + "strid": "00b9d153-6b30-401f-bddc-2d8875db5da1", + "image_id": 205962, + "image_name": "16825.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1383.23, + 1852.764, + 1248.9479999999999, + 1121.6359999999997 + ], + "priority": 14, + "parents": [ + 140480 + ], + "children": [], + "area": 2562798.74772, + "iscrowd": 0, + "segmentation": [], + "text": "The course goes live!\n\nThe course was given 6 times live at EBI over the summer of 2019, repeated at 2-4\nweek intervals, for a total of about 160 trainees.\n\nWe limited the course to 30 students at first, and found this to be a comfortable\nnumber with three trainers. We rotated in giving presentations, with the two non-\npresenters ready to help any students who had any procedural questions. During\nthe exercises, all three presenters were available to help out, plus a fourth cloud\nexpert who joined us.\n\nThe exercises were spread throughout the day, as close to the material as possible\nto maximise the chances of success. They were designed to be isolated, the user\ndid not need to succeed in the Docker exercises before going on to the Gitlab or\nKubernetes exercises, for example. We wanted to be sure that nobody would be left\nbehind for not finishing the exercises, an important point given the amount of work\nwe gave them!\n\nEach student was provided with a virtual machine on the EBI in-house Openstack\ncloud (‘Embassy’). These VMs were made available for two weeks after each\ncourse, so they could complete the exercises at their leisure. However, in practice\nwe saw that nobody made use of their VM after the day of the course, which we\ntook as justification for having not thinned down the curriculum more than we did.\n\nSubsequently, we also gave the course to people from EOSC-Life WP1, in Berlin,\nand to BioExcel2, as a remote attendance course (3 hours per day over 4 days).\nThe remote attendance course suffered from people dropping out towards the end,\nthough it was easier from our viewpoint to have more time to present the material." + }, + { + "id": 140481, + "strid": "ba09fc10-55e7-41c6-956b-b3b5a4c76c35", + "image_id": 205962, + "image_name": "16825.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2775.749, + 703.306, + 454.7750000000001, + 61.849000000000046 + ], + "priority": 15, + "parents": [ + 140500 + ], + "children": [ + 140494, + 140495 + ], + "area": 1952200.926194, + "iscrowd": 0, + "segmentation": [], + "text": "The students" + }, + { + "id": 140495, + "strid": "c079becb-3546-4b33-9bc1-6709fd7b6df1", + "image_id": 205962, + "image_name": "16825.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2814.513, + 846.458, + 1182.6220000000003, + 391.9229999999999 + ], + "priority": 16, + "parents": [ + 140481 + ], + "children": [], + "area": 2382367.044954, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 140494, + "strid": "53d4315c-65de-4780-bc65-c2619c697d0a", + "image_id": 205962, + "image_name": "16825.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2756.957, + 1259.485, + 1246.6460000000002, + 117.41300000000001 + ], + "priority": 17, + "parents": [ + 140481 + ], + "children": [], + "area": 3472345.9871449997, + "iscrowd": 0, + "segmentation": [], + "text": "About half of the students were developers/engineers, the rest were largely\nbioinformaticians, scientific programmers, pre/post-doc students, but also a number\nof managers, coordinators, and project/team leaders" + }, + { + "id": 140482, + "strid": "11cd36b1-9190-457d-befc-ddac86f7a102", + "image_id": 205962, + "image_name": "16825.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2775.718, + 1454.52, + 468.6970000000001, + 59.55400000000009 + ], + "priority": 18, + "parents": [ + 140500 + ], + "children": [ + 140493 + ], + "area": 4037337.3453599997, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 140493, + "strid": "dff9a601-ae6f-4a5e-8c78-238573479b85", + "image_id": 205962, + "image_name": "16825.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2741.993, + 1551.865, + 1246.6460000000002, + 237.12699999999995 + ], + "priority": 19, + "parents": [ + 140482 + ], + "children": [], + "area": 4255202.966945, + "iscrowd": 0, + "segmentation": [], + "text": "We gathered feedback as soon as possible after each event. Most people were\nhappy with the course, though one frequent comment was that there was still too\nmuch material for a one-day course, and that two days might have been better.\nGiven that nobody was able to find the time to complete the exercises after the\nclass, within the two weeks that their VM was still available, we decided to continue\nwith delivery as a one-day course regardless." + }, + { + "id": 140483, + "strid": "4f855de7-aa78-4894-9523-7f2d43ab4b90", + "image_id": 205962, + "image_name": "16825.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2776.234, + 1863.148, + 449.3249999999998, + 72.73900000000003 + ], + "priority": 20, + "parents": [ + 140500 + ], + "children": [ + 140496, + 140492, + 140499 + ], + "area": 5172534.824631999, + "iscrowd": 0, + "segmentation": [], + "text": "Following up" + }, + { + "id": 140492, + "strid": "5c549011-6dcd-4f2c-bb48-1b9fb2eb230f", + "image_id": 205962, + "image_name": "16825.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2744.986, + 1954.291, + 456.067, + 439.952 + ], + "priority": 21, + "parents": [ + 140483 + ], + "children": [], + "area": 5364501.4349259995, + "iscrowd": 0, + "segmentation": [], + "text": "A follow-up survey, about 8\nweeks after each course,\nshowed that many people\nwere not yet able to make use\nof what they had learned.\n\nHowever, the majority had\ndefinite plans to build on what\nthey had learned, and would\nrecommend the course to\ntheir colleagues." + }, + { + "id": 140499, + "strid": "be8a3ece-cd60-4825-8ebb-e2ab851f9533", + "image_id": 205962, + "image_name": "16825.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3251.011, + 2019.037, + 751.4540000000002, + 61.41299999999978 + ], + "priority": 22, + "parents": [ + 140483 + ], + "children": [], + "area": 6563911.496407, + "iscrowd": 0, + "segmentation": [], + "text": "Would you recommend this course to colleagues or new hires?\n36 responses" + }, + { + "id": 140496, + "strid": "3f4ca30d-bc98-4f87-8011-6ee75313bbfd", + "image_id": 205962, + "image_name": "16825.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3461.323, + 2130.487, + 463.18200000000024, + 304.22000000000025 + ], + "priority": 23, + "parents": [ + 140483 + ], + "children": [], + "area": 7374303.654301, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 140484, + "strid": "b1c49c41-1001-4c7f-8e14-0035ee937b69", + "image_id": 205962, + "image_name": "16825.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2777.268, + 2530.42, + 447.846, + 72.81399999999985 + ], + "priority": 24, + "parents": [ + 140500 + ], + "children": [ + 140491 + ], + "area": 7027654.49256, + "iscrowd": 0, + "segmentation": [], + "text": "Following up" + }, + { + "id": 140491, + "strid": "f0c5d6af-eb90-40d2-8238-6e1e6b97fcd6", + "image_id": 205962, + "image_name": "16825.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2743.374, + 2621.471, + 1245.725, + 277.18600000000015 + ], + "priority": 25, + "parents": [ + 140484 + ], + "children": [], + "area": 7191675.383153999, + "iscrowd": 0, + "segmentation": [], + "text": "There is clearly a strong demand for training in cloud technologies at EBI. The\nResOps course goes a long way to filling that demand, and will be maintained as a\nresource for future members of staff.\n\nThe Cloud Consultants are now planning to record the presentations, and make\nthem available online for anyone who’s interested. We are also planning an\nadvanced Kubernetes course, for sometime later this year." + }, + { + "id": 151672, + "strid": "7f764ca9-43d6-4935-88b5-2e4d8d97eb92", + "image_id": 206401, + "image_name": "21311.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 346.69, + 536.59, + 346.71999999999997, + 220.64 + ], + "priority": -1, + "parents": [], + "children": [ + 151668, + 151661, + 151659, + 151658, + 151662, + 151655, + 151654, + 151670, + 151660 + ], + "area": 186030.38710000002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 151654, + "strid": "d0f2defc-cf89-4dfe-b6b3-f51e48240191", + "image_id": 206401, + "image_name": "21311.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 876.652, + 534.332, + 3831.7749999999996, + 246.96500000000003 + ], + "priority": 1, + "parents": [ + 151672 + ], + "children": [], + "area": 468423.216464, + "iscrowd": 0, + "segmentation": [], + "text": "The “grey” digital divide in older adults during COVID-19 in Germany:\nWho is most at risk?" + }, + { + "id": 151655, + "strid": "b806c6ba-3ec2-4b21-8d85-e6c4bd2f8fdc", + "image_id": 206401, + "image_name": "21311.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 2284.255, + 841.923, + 941.6700000000001, + 146.73199999999997 + ], + "priority": 2, + "parents": [ + 151672 + ], + "children": [], + "area": 1923166.8223650001, + "iscrowd": 0, + "segmentation": [], + "text": "Pedros Barnils, Nuria'’*, Schiiz, Benjamin‘?\n1 Prevention and Health Promotion, Bremen University\n2 Digital Public Health, Leibniz ScienceCampus" + }, + { + "id": 151658, + "strid": "74086053-df5e-4b89-be90-dc3871b16960", + "image_id": 206401, + "image_name": "21311.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1278.697, + 1100.128, + 292.501, + 49.60699999999997 + ], + "priority": 3, + "parents": [ + 151672 + ], + "children": [ + 151663 + ], + "area": 1406730.3732159997, + "iscrowd": 0, + "segmentation": [], + "text": 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Jones for his graphic support and\nSarah Fischer for her illustrations" + }, + { + "id": 151670, + "strid": "24910936-18dd-4ca5-a59e-c8a7760b8831", + "image_id": 206401, + "image_name": "21311.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4968.014, + 2550.302, + 285.15099999999984, + 47.19399999999996 + ], + "priority": 17, + "parents": [ + 151672 + ], + "children": [ + 151671 + ], + "area": 12669936.040228002, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 151671, + "strid": "ec9e0944-6c4b-4a0d-8075-7030118110e7", + "image_id": 206401, + "image_name": "21311.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 4081.079, + 2631.046, + 1121.8260000000005, + 236.61099999999988 + ], + "priority": 18, + "parents": [ + 151670 + ], + "children": [], + "area": 10737506.578634, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 134175, + "strid": "3dae0322-c313-4b17-ae1d-e958c8848031", + "image_id": 205705, + "image_name": "15640.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 45.88, + 36.64, + 122.05000000000001, + 90.22 + ], + "priority": -1, + "parents": [], + "children": [ + 134160, + 134163, + 134161, + 134162 + ], + "area": 1681.0432, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 134160, + "strid": "130ea973-a533-4f88-ba95-e22d3570c32c", + "image_id": 205705, + "image_name": "15640.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 77.589, + 227.187, + 979.7740000000001, + 79.78300000000002 + ], + "priority": 1, + "parents": [ + 134175 + ], + "children": [], + "area": 17627.212143, + "iscrowd": 0, + "segmentation": [], + "text": "Extracting biological connections from single cell RNA-Seq data\nwith deep Boltzmann Machines using conditional sampling" + }, + { + "id": 134161, + "strid": "a69f21ca-7d34-4994-ae18-5f6641a39570", + "image_id": 205705, + "image_name": "15640.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 82.038, + 335.685, + 915.033, + 79.334 + ], + "priority": 2, + "parents": [ + 134175 + ], + "children": [], + "area": 27538.92603, + "iscrowd": 0, + "segmentation": [], + "text": "Moritz Hess, Stefan M. 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"children": [], + "area": 36873.481976, + "iscrowd": 0, + "segmentation": [], + "text": "SEXUAL THOUGHTS MEDIATE THE ASSOCIATION BETWEEN SEXUAL\nDYSFUNCTION AND PAIN INTENSITY IN MEN WITH GENITAL PAIN" + }, + { + "id": 189487, + "strid": "034771d1-84e9-45b7-8d01-365bf316afe6", + "image_id": 207894, + "image_name": "9045.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1070.811, + 412.261, + 1389.896, + 151.122 + ], + "priority": 2, + "parents": [ + 189506 + ], + "children": [], + "area": 441453.613671, + "iscrowd": 0, + "segmentation": [], + "text": "Pereira, R., Oliveira, C., & Nobre, P\n\nFaculty of Psychology and Educational Sciences of University of Porto" + }, + { + "id": 189488, + "strid": "12e98c16-06d0-4841-8925-d13ee1d83d92", + "image_id": 207894, + "image_name": "9045.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 431.436, + 656.736, + 409.0810000000001, + 59.10000000000002 + ], + "priority": 3, + "parents": [ + 189506 + ], + "children": [ + 189493 + ], + "area": 283339.552896, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 189493, + "strid": "49ab2e4c-8994-4424-9e9e-526de0e83db8", + "image_id": 207894, + "image_name": "9045.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 127.092, + 800.365, + 1026.832, + 1022.741 + ], + "priority": 4, + "parents": [ + 189488 + ], + "children": [], + "area": 101719.98858, + "iscrowd": 0, + "segmentation": [], + "text": "Men with genital pain seem to share\ncharacteristics with men _ with sexual\ndysfunctions, not only because they often\npresent with sexual dysfunctions but also\nstudies suggest that cognitive factors are\nassociated with pain (Davis, Binik & Carrier,\n2009). However, there’s little information\nreporting how thoughts during sexual activity\nhelp to explain the link between sexual\nfunctioning and genital pain (Nickel, Mullins &\nTripp, 2008). Therefore, this study aims to\ntest the mediation role of sexually-related\nthoughts on the relationship between sexual\nfunctioning and pain intensity in men with\ngenital pain.\n\nKey-words: genital pain; cognitions; sexual functioning;\nsexuality; pain intensity" + }, + { + "id": 189489, + "strid": "db1ebaa1-ec77-4bb5-a654-f345d7aa90ec", + "image_id": 207894, + "image_name": "9045.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2223.972, + 657.634, + 296.0329999999999, + 58.89200000000005 + ], + "priority": 5, + "parents": [ + 189506 + ], + "children": [ + 189495, + 189496, + 189494 + ], + "area": 1462559.6022480002, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 189494, + "strid": "68fccfd9-ca00-4950-8dc1-f91f5879f430", + "image_id": 207894, + "image_name": "9045.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1297.108, + 802.41, + 2108.892, + 128.865 + ], + "priority": 6, + "parents": [ + 189489 + ], + "children": [], + "area": 1040812.43028, + "iscrowd": 0, + "segmentation": [], + "text": "Participants and Procedures: A total of 50 men with genital pain completed an\nonline survey." + }, + { + "id": 189495, + "strid": "247b0135-ef99-4252-9950-aaeee3fc8dc3", + "image_id": 207894, + "image_name": "9045.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1297.108, + 1000.822, + 2115.0289999999995, + 329.323 + ], + "priority": 7, + "parents": [ + 189489 + ], + "children": [], + "area": 1298174.222776, + "iscrowd": 0, + "segmentation": [], + "text": "Measures: Participants answered the automatic thoughts subscale of the Sexual\nModes Questionnaire - Male Version (SMQ; Nobre & Pinto-Gouveia, 2003a), the\nInternational Index of Erectile Function (IIEF; Rosen et al., 1997; translated and\nadapted from Nobre, 2002) and the Short Form of McGill Pain Questionnaire (SF-\nMPQ; Melzack, 1987; translated and adapted from Azevedo et al., 2007)." + }, + { + "id": 189496, + "strid": "a44cb5d7-4cc9-4ba2-a555-c3bb566e36e4", + "image_id": 207894, + "image_name": "9045.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1297.108, + 1401.737, + 2108.892, + 390.6869999999999 + ], + "priority": 8, + "parents": [ + 189489 + ], + "children": [], + "area": 1818204.276596, + "iscrowd": 0, + "segmentation": [], + "text": "Data analysis: Mediation analysis was conducted through linear regression\nequations (Baron & Kenny, 1986). Sexually-related thoughts (total of SMQ —\nsubscale of thoughts) were considered the mediator, being Sexual functioning (total\nof IIEF) the independent variable (IV), and Pain intensity (total of SF-MPQ) the\ndependent variable (DV). A Sobel test was used to assess the significance of the\nmediation effect." + }, + { + "id": 189490, + "strid": "338fb7c5-2ddc-4d3e-a6ce-01d10949528f", + "image_id": 207894, + "image_name": "9045.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1659.454, + 1933.324, + 227.44299999999998, + 57.52099999999996 + ], + "priority": 9, + "parents": [ + 189506 + ], + "children": [ + 189503, + 189505, + 189504, + 189497 + ], + "area": 3208262.245096, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 189503, + "strid": "4d63b0bc-a108-4076-b147-539b7aebd428", + "image_id": 207894, + "image_name": "9045.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 155.525, + 2220.039, + 1434.123, + 491.8359999999998 + ], + "priority": 10, + "parents": [ + 189490 + ], + "children": [ + 189500 + ], + "area": 345271.56547500007, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 189500, + "strid": "d79483fd-a24a-411f-baec-56ad7f3802e8", + "image_id": 207894, + "image_name": "9045.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 132.717, + 2090.361, + 1481.368, + 80.36999999999989 + ], + "priority": 11, + "parents": [ + 189503 + ], + "children": [], + "area": 277426.44083700003, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1 - Correlations (r Pearson) between Sexual functioning, Cognitions during sexual activity and Pain\nintensity in a sample of men with genital pain (N = 50)" + }, + { + "id": 189504, + "strid": "a119b2b4-bf4d-4f84-aba0-58ede6488fc6", + "image_id": 207894, + "image_name": "9045.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 149.352, + 2944.928, + 1432.17, + 560.2309999999998 + ], + "priority": 12, + "parents": [ + 189490 + ], + "children": [ + 189501 + ], + "area": 439830.886656, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 189501, + "strid": "50747fb7-cfd9-4f8a-ac80-446876065bbf", + "image_id": 207894, + "image_name": "9045.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 132.717, + 2837.438, + 1453.969, + 74.88999999999987 + ], + "priority": 13, + "parents": [ + 189504 + ], + "children": [], + "area": 376576.2590460001, + "iscrowd": 0, + "segmentation": [], + "text": "Table 2 - Linear Regression analysis of Mediation between Sexual functioning, Cognitions during sexual\nactivity and Pain intensity in a sample of men with genital pain (N = 50)" + }, + { + "id": 189497, + "strid": "290f8b9d-3e46-4b88-83c6-8e4de8e8e77c", + "image_id": 207894, + "image_name": "9045.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1815.697, + 2125.584, + 1561.213, + 525.2950000000001 + ], + "priority": 14, + "parents": [ + 189490 + ], + "children": [], + "area": 3859416.4920479995, + "iscrowd": 0, + "segmentation": [], + "text": "In Step 1, the regression of the IV on the mediator was\nsignificant, B = -.68, t(50) = -5.8, p <.001. Step 2 showed that\nthe regression of the IV on the DV was also significant, B = -\n.39, t(50) = -2.6, p =.014. Step 3 showed a significant effect of\nthe mediator on the DV, 6 = .68, t(50) = 3.8, p =.001. Also, the\nIV was no longer a significant predictor of the DV, 6 = .06, t(50)\n= .387, p =.711. Additionally, the Sobel test found a partial\nmediation effect (z = 2.37, p = .018)." + }, + { + "id": 189505, + "strid": "a56e9d53-06f1-4802-8054-b97d600df37d", + "image_id": 207894, + "image_name": "9045.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1764.989, + 2815.752, + 1661.504, + 475.0500000000002 + ], + "priority": 15, + "parents": [ + 189490 + ], + "children": [ + 189502 + ], + "area": 4969771.306728, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 189502, + "strid": "c76ebd08-0c19-4153-a802-fd59ea969cb2", + "image_id": 207894, + "image_name": "9045.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1793.692, + 3373.058, + 1540.018, + 75.2840000000001 + ], + "priority": 16, + "parents": [ + 189505 + ], + "children": [], + "area": 6050227.1501360005, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. Mediation model of linear regression between Sexual functioning, Cognitions during sexual activity and Pain\nintensity in a sample of men with genital pain (N = 50)" + }, + { + "id": 189491, + "strid": "f44d7509-b32b-4f30-ad9e-baaac5abef3a", + "image_id": 207894, + "image_name": "9045.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 692.976, + 3668.988, + 416.8269999999999, + 62.32900000000018 + ], + "priority": 17, + "parents": [ + 189506 + ], + "children": [ + 189498 + ], + "area": 2542520.628288, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 189498, + "strid": "c026ae60-344f-45c3-b293-c65ded584785", + "image_id": 207894, + "image_name": "9045.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 127.195, + 3827.142, + 1532.051, + 715.098 + ], + "priority": 18, + "parents": [ + 189491 + ], + "children": [], + "area": 486793.32668999996, + "iscrowd": 0, + "segmentation": [], + "text": "Findings showed that sexually-related thoughts partially mediated\nthe relationship between sexual functioning and pain intensity in\nmen with genital pain. Results are consistent with previous research,\nsuggesting that negative sexually-related thoughts are one possible\nfactor contributing to explain how sexual functioning indirectly predict\npain intensity (Pontari, 2004, 2013). Particularly, the direction of the\nmediation shows that, as negative cognitions during sexual activity\nincreases, the pain intensity increases. This means that sexually-\nrelated thoughts may act as a suppressor of the sexual functioning.\nOverall, findings emphasize the relevance of cognitions in predicting\npain intensity and suggest the use of cognitive techniques in the\ntreatment of male genital pain (Nickel & Shoskes, 2010)." + }, + { + "id": 189492, + "strid": "2cd7066d-9713-45bf-ae46-273c1baca922", + "image_id": 207894, + "image_name": "9045.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2439.282, + 3666.96, + 381.895, + 61.83100000000013 + ], + "priority": 19, + "parents": [ + 189506 + ], + "children": [ + 189499 + ], + "area": 8944749.52272, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 189499, + "strid": "13b2a31e-51ba-44a5-bce6-586d7058252b", + "image_id": 207894, + "image_name": "9045.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1829.911, + 3808.045, + 1588.4340000000002, + 477.4399999999996 + ], + "priority": 20, + "parents": [ + 189492 + ], + "children": [], + "area": 6968383.433995, + "iscrowd": 0, + "segmentation": [], + "text": "Azevedo, L.F., Pereira, A.C., Dias, C., Agualusa, L., Lemos, L., Roméo, et al. (2007). Tradugao, adaptacao cultural e estudo multicéntrico de instrumentos para rastreio e\navaliagao do impacto da dor cronica. Dor, 15, 6-37\n\nBaron, R. M., & Kenny, D. A. (1986). The moderator-mediator variable distinction in social psychology research: conceptual, strategic and statistical considerations. Journal of\nPersonality and Social Psychology, 51(6), 1173-1182.\n\nDavis, S. N. P., Binik, Y. M., & Carrier, S. (2009). Sexual dysfunction and pelvic pain in men: A male sexual pain disorder? Journal of Sex & Marital Therapy, 35, 182-205. doi:\n10.1080/009262308027 16310\n\nMelzack, R. (1987). The short-form McGill pain questionnaire. Pain, 30, 191-197.\n\nNickel, J. C., & Shoskes, D. A. (2010). Phenotypic approach to the management of the chronic prostatitis/chronic pelvic pain syndrome. BJU International, 1252-1263.\ndoi:10.1111/.1464-410X.2010.09701.x\n\nNickel, J. C., Mullins, C., & Tripp, D. A. (2008). Development of an evidence-based cognitive behavioral treatment program for men with chronic prostatitis/chronic pelvic pain\nsyndrome. World Journal of Urology, 26, 167-172. doi: 10.1007/s00345-008-0235-6\n\nNobre. P. J., & Pinto-Gouveia, J. (2003a). Sexual modes questionnaire: Measure to assess the interaction among cognitions, emotions, and sexual response. The Journal of\nSex Research, 368-382. doi: 10.1080/00224490209552203.\n\nPontari, M. A. (2013). Etiology of chronic prostatitis/chronic pelvic pain syndrome: psychoimmunoneurendocrine dysfunction (PINE syndrome) or just really a bad infection?\nWorld Journal of Urology. doi: 10.1007/s00345-013-1061-z\n\nPontari, M. A,. & Ruggieri, M. R. (2004). Mechanisms in prostatitis/chronic pelvic pain syndrome. The Journal of Urology, 839-845. doi: 10.1097/01 .ju.0000136002.76898.04" + }, + { + "id": 49488, + "strid": "3b919103-9a57-4167-be33-c9886191d68f", + "image_id": 202440, + "image_name": "11870.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 80.51, + 66.75, + 73.92, + 229.14999999999998 + ], + "priority": -1, + "parents": [], + "children": [ + 49487, + 49469, + 49468, + 49471, + 49485, + 49467, + 49470 + ], + "area": 5374.0425000000005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 49467, + "strid": "a09c93d0-116f-4624-a498-de314ca645f2", + "image_id": 202440, + "image_name": "11870.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 245.76, + 175.965, + 2845.688, + 112.035 + ], + "priority": 1, + "parents": [ + 49488 + ], + "children": [], + "area": 43245.1584, + "iscrowd": 0, + "segmentation": [], + "text": "Meningococcal Epiglottitis — A Rare But Important Diagnosis" + }, + { + "id": 49468, + "strid": "0720efdb-94f8-4ab6-9623-e2553c2bc98e", + "image_id": 202440, + "image_name": "11870.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 744.099, + 292.637, + 1841.3229999999999, + 46.19400000000002 + ], + "priority": 2, + "parents": [ + 49488 + ], + "children": [], + "area": 217750.89906300002, + "iscrowd": 0, + "segmentation": [], + "text": "Dr. L. Downs, Dr. R. Devi, Dr. D. Waghorn & Dr. J. O’Driscoll. Buckinghamshire Healthcare NHS Trust" + }, + { + "id": 49469, + "strid": "442f0c8e-f68c-486b-b3f0-492048893c2b", + "image_id": 202440, + "image_name": "11870.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 130.405, + 465.246, + 390.59400000000005, + 61.087999999999965 + ], + "priority": 3, + "parents": [ + 49488 + ], + "children": [ + 49477, + 49475, + 49476 + ], + "area": 60670.40463, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 49475, + "strid": "5589978c-8a95-48f7-af29-4731cebae48e", + "image_id": 202440, + "image_name": "11870.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 127.401, + 607.207, + 945.5170000000002, + 354.51200000000006 + ], + "priority": 4, + "parents": [ + 49469 + ], + "children": [], + "area": 77358.77900699999, + "iscrowd": 0, + "segmentation": [], + "text": "Since the introduction of the Hib vaccination\nto the UK’s childhood immunisation\nprogramme in 1992 there has been a huge\ndrop in the incidence of Haemophilus\ninfluenzae infection in the under 5’s (Graph\n1),4:" + }, + { + "id": 49476, + "strid": "e8212989-50b0-48f6-90a6-6f38fb0395ac", + "image_id": 202440, + "image_name": "11870.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 47.516, + 1108.921, + 1040.164, + 778.463 + ], + "priority": 5, + "parents": [ + 49469 + ], + "children": [ + 49473 + ], + "area": 52691.490236, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 49473, + "strid": "aabb00c4-db30-454d-a89a-21cd60ef1ef1", + "image_id": 202440, + "image_name": "11870.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 127.353, + 1051.883, + 954.7980000000001, + 43.04899999999998 + ], + "priority": 6, + "parents": [ + 49476 + ], + "children": [], + "area": 133960.455699, + "iscrowd": 0, + "segmentation": [], + "text": "Graph 1: Laboratory Confirmed Hib in England 1990-2012,," + }, + { + "id": 49477, + "strid": "f5b4ab76-04e4-4b05-b9f5-15a686ab9887", + "image_id": 202440, + "image_name": "11870.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 124.297, + 1952.565, + 951.7639999999999, + 832.991 + ], + "priority": 7, + "parents": [ + 49469 + ], + "children": [], + "area": 242697.971805, + "iscrowd": 0, + "segmentation": [], + "text": "As Haemophilus influenzae is the major cause\nof childhood epiglottitis, the incidence of this\nhas also fallen. After introduction of the\nvaccine, the annual incidence in Europe has\ndecreased from around 5 to 0.7 per 100,000\nchildren immunised,,. ,,.\n\nAny change to the incidence of epiglottitis in\nadults however has not been so clear,,.,.. This\nis partly due to the wider variety of pathogens\nthat cause the disease. Here we present an\nunusual case of epiglottitis caused by\nNeisseria meningitidis and review previous\ncase reports of this diagnosis." + }, + { + "id": 49470, + "strid": "dbf2ab10-0f2a-4df6-9a04-4b3930cf144f", + "image_id": 202440, + "image_name": "11870.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 128.775, + 2878.343, + 380.48300000000006, + 70.61200000000008 + ], + "priority": 8, + "parents": [ + 49488 + ], + "children": [ + 49483, + 49478 + ], + "area": 370658.619825, + "iscrowd": 0, + "segmentation": [], + "text": "Case Report" + }, + { + "id": 49478, + "strid": "8c5da0a5-da9b-4ea8-8ce0-cf9d0da94f25", + "image_id": 202440, + "image_name": "11870.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 126.829, + 3017.88, + 948.53, + 1424.2399999999998 + ], + "priority": 9, + "parents": [ + 49470 + ], + "children": [], + "area": 382754.70252, + "iscrowd": 0, + "segmentation": [], + "text": "A 63 year old previously well man presented\nto our emergency department with a 3-day\nhistory of sore throat and inability to swallow.\n\nHe had inspiratory stridor and a hoarse voice.\nHis oxygen saturations were 92% on air with a\nrespiratory rate of over 30. He was\ntachycardic (pulse 125) but his blood pressure\nwas normal and he was afebrile.\n\nOn examination he had widespread\ntransmitted sounds throughout both lungs\nand a swollen uvula and tongue. Epiglottitis\nwas suspected and dexamethasone was\nadministered along with teicoplanin,\nclindamycin, gentamicin and metronidazole\n(he was penicillin allergic).\n\nHe was transferred to theatre for emergency\nintubation. On laryngoscopy the vocal cords\ncould not be visualised due to an oedematous\nepiglottis. Intubation was successful using a\ngum elastic bougie and railroaded\nendotracheal tube." + }, + { + "id": 49483, + "strid": "209eef0b-b38f-4170-89fd-fd5bdc0bdbd5", + "image_id": 202440, + "image_name": "11870.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1156.898, + 455.249, + 934.7450000000001, + 1492.685 + ], + "priority": 10, + "parents": [ + 49470 + ], + "children": [], + "area": 526676.6576019999, + "iscrowd": 0, + "segmentation": [], + "text": "Bloods showed a raised white cell count at\n17.7 x 10° (neutrophilia 16.5 x 10%) and a\nraised CRP at 265.\n\nA CT scan of his neck showed non-specific\nsoft tissue swelling of the nasopharynx,\noropharynx and hypopharynx but no\nevidence of an abscess.\n\nOn day 1 post admission, blood cultures\ngrew a fully sensitive gram-negative\ndiplococcus and his antibiotics were\nrationalised to ciprofloxacin alone. This was\nsubsequently confirmed as Neisseria\nmeningitidis type W135.\n\nHe had ongoing pyrexia for several days after\nthis but an echocardiogram showed no\nevidence of endocarditis. His pyrexia\neventually settled and antibiotics were\nstopped at day 9.\n\nA repeat nasendoscopy on day 10 showed\nmild swelling of the right supraglottis, but an\notherwise normal airway." + }, + { + "id": 49471, + "strid": "3d605074-a5c6-48ad-bec4-6815da78c85b", + "image_id": 202440, + "image_name": "11870.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1160.995, + 2037.223, + 326.72699999999986, + 59.7800000000002 + ], + "priority": 11, + "parents": [ + 49488 + ], + "children": [ + 49479, + 49480, + 49482, + 49484, + 49481 + ], + "area": 2365205.7168849995, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion" + }, + { + "id": 49480, + "strid": "56f76912-b791-4263-9781-a55ecfed5058", + "image_id": 202440, + "image_name": "11870.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1155.095, + 2177.428, + 933.097, + 1010.4250000000002 + ], + "priority": 12, + "parents": [ + 49471 + ], + "children": [], + "area": 2515136.1956599997, + "iscrowd": 0, + "segmentation": [], + "text": "Ten other cases of epiglottitis caused by N.\nmeningiditis have been reported in the\nliterature (See table 1 for summary).\n\nThe average age of patients with N.\nmeningitidis epiglottitis was 66.2 years. Of\nthe 11 patients, including our own, 8\nrequired airway intervention either in the\nform of oral intubation, tracheostomy or\nemergency cricothyroidotomy (72%).\n\nThis rate of airway intervention appears\nhigher than average for adult epiglottitis.\nThe literature gives rates of between\n10-28%,5.5,, suggesting that meningococcal\nepiglottitis may cause a more severe\ninfection than other organisms." + }, + { + "id": 49479, + "strid": "e7381ae2-9097-47bc-9e00-8ebc678f4a7d", + "image_id": 202440, + "image_name": "11870.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1145.961, + 3310.431, + 1584.713, + 1159.6739999999995 + ], + "priority": 13, + "parents": [ + 49471 + ], + "children": [ + 49472 + ], + "area": 3793624.819191, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 49472, + "strid": "354475c8-dd07-4866-8b21-783e9f5f252f", + "image_id": 202440, + "image_name": "11870.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1427.071, + 3236.276, + 1038.7089999999998, + 43.95499999999993 + ], + "priority": 14, + "parents": [ + 49479 + ], + "children": [], + "area": 4618395.627595999, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1: Summary of Cases of Meningococcal Epiglottitis" + }, + { + "id": 49484, + "strid": "6c1f8c3f-aad2-4d82-85aa-7fa2ba3bac88", + "image_id": 202440, + "image_name": "11870.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2190.136, + 456.221, + 981.0410000000002, + 894.203 + ], + "priority": 15, + "parents": [ + 49471 + ], + "children": [], + "area": 999186.036056, + "iscrowd": 0, + "segmentation": [], + "text": "Our case is the only reported infection caused\nby meningococcus group W135 (MenW).\nRecently, Public Health England have reported\nan increase in invasive meningococcal\ninfections being caused by MenV,, in particular\nserotype 2a, which our patient had.\n\nOver the last 3 years the incidence\nof MenW has increased year on year from 27\ncases in 2010 to 93 cases in 2013,, (graph 2).\nThis is across all age groups and does not seem\nto be associated with travel or clusters of\nhousehold cases. This raises the possibility that\nthe incidence of epiglottitis caused by this\norganism may also increase in the next few\nyears." + }, + { + "id": 49482, + "strid": "6517960f-289a-42e7-a346-c3557ac101df", + "image_id": 202440, + "image_name": "11870.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2176.22, + 1507.402, + 1009.2400000000002, + 856.8110000000001 + ], + "priority": 16, + "parents": [ + 49471 + ], + "children": [ + 49474 + ], + "area": 3280438.38044, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 49474, + "strid": "787cd74e-8c55-4ac5-ad74-99af94b0ab03", + "image_id": 202440, + "image_name": "11870.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2336.627, + 1548.342, + 781.1169999999997, + 87.59400000000005 + ], + "priority": 17, + "parents": [ + 49482 + ], + "children": [], + "area": 3617897.722434, + "iscrowd": 0, + "segmentation": [], + "text": "Graph 2: Cases of Invasive Meningococcal group\nW Infection over time,," + }, + { + "id": 49481, + "strid": "d5e85f67-ef1f-45ed-b8ff-c9ce8953ed1e", + "image_id": 202440, + "image_name": "11870.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2200.133, + 2501.776, + 969.0799999999999, + 591.8710000000001 + ], + "priority": 18, + "parents": [ + 49471 + ], + "children": [], + "area": 5504239.9362079995, + "iscrowd": 0, + "segmentation": [], + "text": "Finally it is worth remembering the need to\nconsider epiglottitis in the adult patient who\npresents in respiratory distress. In the past\nacute epiglottitis has been thought of almost\nexclusively as a childhood illness but this is\nnow not the case.\n\nGiven the potentially significant\nmortality of this treatable disease, clinical\nsuspicion should be high to ensure adequate\nmanagement is initiated early." + }, + { + "id": 49485, + "strid": "6fa16864-b234-4379-8df7-a6775f5f5ed7", + "image_id": 202440, + "image_name": "11870.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2795.5, + 3427.997, + 181.13200000000006, + 31.940999999999804 + ], + "priority": 19, + "parents": [ + 49488 + ], + "children": [ + 49486 + ], + "area": 9582965.613499999, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 49486, + "strid": "bb5e4b55-51d6-4714-9d5a-de7c628799be", + "image_id": 202440, + "image_name": "11870.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2794.755, + 3498.381, + 449.6390000000001, + 904.5089999999996 + ], + "priority": 20, + "parents": [ + 49485 + ], + "children": [], + "area": 9777117.791655, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 49487, + "strid": "f3b61777-2043-4da2-95e8-774a837560ae", + "image_id": 202440, + "image_name": "11870.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2795.184, + 4431.975, + 312.567, + 17.675000000000182 + ], + "priority": 21, + "parents": [ + 49488 + ], + "children": [], + "area": 12388185.608400002, + "iscrowd": 0, + "segmentation": [], + "text": "For Further References Ask the Author." + }, + { + "id": 179720, + "strid": "1a7d3a0d-9726-44ff-8d69-d1f9a605158e", + "image_id": 207519, + "image_name": "8347.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 546.61, + 65.01, + 201.14, + 113.98 + ], + "priority": -1, + "parents": [], + "children": [ + 179706, + 179707, + 179705, + 179708, + 179710, + 179709, + 179704 + ], + "area": 35535.11610000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 179704, + "strid": "5b67e9fb-f605-45de-b3cb-c14ff6951339", + "image_id": 207519, + "image_name": "8347.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 549.307, + 247.865, + 1761.644, + 247.788 + ], + "priority": 1, + "parents": [ + 179720 + ], + "children": [], + "area": 136153.979555, + "iscrowd": 0, + "segmentation": [], + "text": "COMPLICACIONES POSTOPERATORIAS EN CIRUGIA\nCARDIACA CON Y SIN USO DE CIRCULACION\nEXTRACORPOREA EN UN HOSPITAL DE ALTA COMPLEJIDAD\nDE LA CIUDAD DE CARTAGENA - BOLIVAR" + }, + { + "id": 179705, + "strid": "a8e9c032-a45d-461d-9f3f-3b0187ad4093", + "image_id": 207519, + "image_name": "8347.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 636.077, + 632.509, + 1533.9600000000003, + 201.793 + ], + "priority": 2, + "parents": [ + 179720 + ], + "children": [], + "area": 402324.427193, + "iscrowd": 0, + "segmentation": [], + "text": "Olivo Martinez Yenifer!*, Orozco-Ugarriza Mauricio2~\n\nIMagister en Bioquimica Clinica - *Magister en Genetica\n*Universidad de San Buenaventura- Facultad de Ciencias de la Salud" + }, + { + "id": 179706, + "strid": "5fc6f4d4-c684-431f-bc34-50f90faa82fb", + "image_id": 207519, + "image_name": "8347.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1196.996, + 1056.417, + 402.53700000000003, + 37.37799999999993 + ], + "priority": 3, + "parents": [ + 179720 + ], + "children": [ + 179711 + ], + "area": 1264526.923332, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 179711, + "strid": "c23d4c83-61ff-4286-b0f4-65221c2e1780", + "image_id": 207519, + "image_name": "8347.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 164.909, + 1184.752, + 2437.144, + 315.019 + ], + "priority": 4, + "parents": [ + 179706 + ], + "children": [], + "area": 195376.26756799998, + "iscrowd": 0, + "segmentation": [], + "text": "La finalidad de realizar este estudio surge a partir de la necesidad identificar las complicaciones\npostquirurgicas mas frecuentes en el paciente sometido a cirugia cardiaca que pueden estar asociados con\nel tipo de cirugia y los procemientos quirurgicos empleados y compararlos_ con la literatura cientifica\nmundial, dado que existe una ccontroversia en cuanto a los eventuales beneficios de la cirugia de\nrevascularizacién miocardica sin la técnica de circulacién extracorporea (SCEC) comparada con la\nrevascularizacio6n miocardica con circulacién extracorporea (CEC)." + }, + { + "id": 179708, + "strid": "69ab74b8-60a1-4513-9690-273425d5da36", + "image_id": 207519, + "image_name": "8347.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 481.186, + 1623.045, + 502.90000000000003, + 37.749000000000024 + ], + "priority": 5, + "parents": [ + 179720 + ], + "children": [ + 179712 + ], + "area": 780986.53137, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 179712, + "strid": "38797d9d-b05b-463f-9b43-6af041bc9a3e", + "image_id": 207519, + "image_name": "8347.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 170.932, + 1783.909, + 1113.499, + 259.3789999999999 + ], + "priority": 6, + "parents": [ + 179708 + ], + "children": [], + "area": 304927.133188, + "iscrowd": 0, + "segmentation": [], + "text": "Determinar la frecuencia de complicaciones\npostoperatorias en cirugia cardiaca (CC) y su\nrelacidn con el uso de circulacion extracorporea\n(CEC) en un hospital de alta complejidad de la\nciudad de Cartagena - Bolivar." + }, + { + "id": 179707, + "strid": "77d8cc4e-e270-4fc3-96ab-826b3ed23b6e", + "image_id": 207519, + "image_name": "8347.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1775.588, + 1622.895, + 631.0220000000002, + 37.02600000000007 + ], + "priority": 7, + "parents": [ + 179720 + ], + "children": [ + 179713 + ], + "area": 2881592.8872599998, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 179713, + "strid": "e861c466-6ecc-47f3-8fc0-402977206042", + "image_id": 207519, + "image_name": "8347.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1501.807, + 1740.109, + 1178.6940000000002, + 368.33100000000013 + ], + "priority": 8, + "parents": [ + 179707 + ], + "children": [], + "area": 2613307.876963, + "iscrowd": 0, + "segmentation": [], + "text": "Estudio retrospectivo, analitico, transversal con 148\npacientes sometidos a cirugia cardiaca con y sin uso\nde CEC.\n\nPeriodo: 2010 a 2011.\n\nVariables: Se analizaron las variables\nsociodemograficas, tipo de cirugia, uso de CEC,\ntiempo de CEC y la morbimortalidad postoperatoria." + }, + { + "id": 179709, + "strid": "d3a3a11c-c8ed-49a2-857b-d15da4f65159", + "image_id": 207519, + "image_name": "8347.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2029.655, + 2310.796, + 331.27099999999996, + 37.14899999999989 + ], + "priority": 9, + "parents": [ + 179720 + ], + "children": [ + 179718, + 179714, + 179719 + ], + "area": 4690118.655379999, + "iscrowd": 0, + "segmentation": [], + "text": "RESULTADOS" + }, + { + "id": 179718, + "strid": "f3052260-5fc5-4187-af74-6fc90d946234", + "image_id": 207519, + "image_name": "8347.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 34.482, + 2325.105, + 1606.589, + 1111.879 + ], + "priority": 10, + "parents": [ + 179709 + ], + "children": [ + 179716 + ], + "area": 80174.27060999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 179716, + "strid": "2241c528-da00-43a4-abc3-6900adc9ea66", + "image_id": 207519, + "image_name": "8347.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 79.492, + 2198.656, + 1347.996, + 96.2170000000001 + ], + "priority": 11, + "parents": [ + 179718 + ], + "children": [], + "area": 174775.562752, + "iscrowd": 0, + "segmentation": [], + "text": "Tabla 1. Frecuencia y asociacion entre las complicaciones\npostoperatorias y el uso de circulaci6n extracorporea." + }, + { + "id": 179714, + "strid": "9ed11c37-213b-4271-ad9f-8c8c6294ff2b", + "image_id": 207519, + "image_name": "8347.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1810.799, + 2434.737, + 783.2979999999998, + 950.1130000000003 + ], + "priority": 12, + "parents": [ + 179709 + ], + "children": [], + "area": 4408819.324863, + "iscrowd": 0, + "segmentation": [], + "text": "Los resultados obtenidos\nmuestran que los pacientes\nsometidos a cirugia cardiaca con\nuso de CEC presentaron una\nincidencia del 57 % (67 casos)\nde complicaciones postoperatorias\ny una mortalidad del 11,9 %\ncorrespondiente a 14 casos,\nmientras que la incidencia de\npacientes que no requirieron el\nuso de CEC’ durante la cirugia\ncorresponde a 20,9% (31 casos),\nrespecto al desarrollo de\ncomplicaciones se observo que 16\ncasos, es decir el 51,6%\ndesarrollaron complicaciones\npostoperatorias y una mortalidad\ndel 12,9%." + }, + { + "id": 179719, + "strid": "955d37ff-295c-4ac7-b092-98c52b2a79d0", + "image_id": 207519, + "image_name": "8347.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1097.95, + 3596.925, + 1584.061, + 1057.1509999999998 + ], + "priority": 13, + "parents": [ + 179709 + ], + "children": [ + 179717 + ], + "area": 3949243.8037500004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 179717, + "strid": "e678deb1-1cae-4054-aa17-418816c6c946", + "image_id": 207519, + "image_name": "8347.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1057.828, + 3478.595, + 1649.163, + 95.96900000000005 + ], + "priority": 14, + "parents": [ + 179719 + ], + "children": [], + "area": 3679755.1916599995, + "iscrowd": 0, + "segmentation": [], + "text": "Tabla 2. Frecuencia y estimacion de asociacion de las complicaciones\npostoperatorias segutn el tiempo de circulacion extracorporea." + }, + { + "id": 179710, + "strid": "f918ef81-d96c-413a-8c73-80106b8e2303", + "image_id": 207519, + "image_name": "8347.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 328.618, + 3596.338, + 398.497, + 38.29500000000007 + ], + "priority": 15, + "parents": [ + 179720 + ], + "children": [ + 179715 + ], + "area": 1181821.4008840001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 179715, + "strid": "368452b1-5adb-451c-9d92-c2a2db5ce14e", + "image_id": 207519, + "image_name": "8347.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 113.055, + 3704.269, + 812.7249999999999, + 840.5220000000004 + ], + "priority": 16, + "parents": [ + 179710 + ], + "children": [], + "area": 418786.131795, + "iscrowd": 0, + "segmentation": [], + "text": "El uso de la CEC en nuestro estudio\nse relaciondé con el desarrollo de un\nmayor numero de complicaciones,\nexclusivas en este grupo de\npacientes, entre las que se\ndestacan las complicaciones\nrespiratorias como el derrame\npleural, las complicaciones\ncardiacas como shock cardiogénico,\nla anemia y las alteraciones en la\nfuncion neuroldgica. Mientras que\nlos pacientes sometidos a cirugia\nsin CEC predominaron en menor\nproporcion complicaciones\ndiferentes a las anteriormente\nmencionadas." + }, + { + "id": 194018, + "strid": "bca0c112-62fe-413e-b8c8-f5659c9fad7c", + "image_id": 208089, + "image_name": "9347.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 133.11, + 76.12, + 328.53, + 100.57 + ], + "priority": -1, + "parents": [], + "children": [ + 194016, + 193996, + 193995, + 193994, + 193997, + 193998, + 193993 + ], + "area": 10132.333200000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 193993, + "strid": "03865c66-3d99-4d4a-9b0c-d49c7703aac8", + "image_id": 208089, + "image_name": "9347.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 228.268, + 249.915, + 2072.153, + 211.398 + ], + "priority": 1, + "parents": [ + 194018 + ], + "children": [], + "area": 57047.597219999996, + "iscrowd": 0, + "segmentation": [], + "text": "Antibody-based SAW sensor for the detection of\nexplosives" + }, + { + "id": 193995, + "strid": "70a2e732-6790-422f-bcbb-8d766f17b9a8", + "image_id": 208089, + "image_name": "9347.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 233.198, + 640.9, + 2658.831, + 155.73199999999997 + ], + "priority": 2, + "parents": [ + 194018 + ], + "children": [], + "area": 149456.5982, + "iscrowd": 0, + "segmentation": [], + "text": "Steffen Ramin and Michael G. Weller\nBundesanstalt fiir Materialforschung und -priifung (BAM), Richard-Willstatter-Str. 11, D-12489 Berlin" + }, + { + "id": 193994, + "strid": "f71328b5-9325-48f2-99f6-08a15b47c705", + "image_id": 208089, + "image_name": "9347.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 240.373, + 825.892, + 455.555, + 66.24800000000005 + ], + "priority": 3, + "parents": [ + 194018 + ], + "children": [ + 193999 + ], + "area": 198522.137716, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 193999, + "strid": "4711773b-05d7-4a81-9b58-e70b7d5ca261", + "image_id": 208089, + "image_name": "9347.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 236.293, + 930.574, + 1393.13, + 348.99699999999996 + ], + "priority": 4, + "parents": [ + 193994 + ], + "children": [], + "area": 219888.122182, + "iscrowd": 0, + "segmentation": [], + "text": "One of the important analytical challenges is the Ttast and reliable\ntrace detection of explosives in the context of security issues,\nammunition disposal, and environmental pollution. Antibodies (Ab)\nare a promising tool for this purpose and the combination with a\nsurface acoustic wave (SAW) sensor opens the opportunity of highly\nselective and fast, label-free detection." + }, + { + "id": 193996, + "strid": "f14afc33-6fb6-412a-a26e-dc991ac0624e", + "image_id": 208089, + "image_name": "9347.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 237.611, + 1378.297, + 488.303, + 82.62400000000002 + ], + "priority": 5, + "parents": [ + 194018 + ], + "children": [ + 194002, + 194004, + 194008, + 194000, + 194007, + 194001, + 194003, + 194006, + 194005 + ], + "area": 327498.528467, + "iscrowd": 0, + "segmentation": [], + "text": "Experimental" + }, + { + "id": 194000, + "strid": "861952d0-688f-4509-935f-dc06046bff35", + "image_id": 208089, + "image_name": "9347.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 234.632, + 1471.938, + 1390.617, + 115.10100000000011 + ], + "priority": 6, + "parents": [ + 193996 + ], + "children": [], + "area": 345363.75681600004, + "iscrowd": 0, + "segmentation": [], + "text": "A commercially available SAW sensor (sam5 blue, SAW Instruments)\nwas used for liquid handling and detection." + }, + { + "id": 194001, + "strid": "14a3a516-69ce-4c21-a24a-bdd9a1f045ae", + "image_id": 208089, + "image_name": "9347.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 233.99, + 1618.0, + 955.233, + 404.76099999999997 + ], + "priority": 7, + "parents": [ + 193996 + ], + "children": [], + "area": 378595.82, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 194002, + "strid": "544c70b0-08fc-4a30-bc65-5abb3b9183c1", + "image_id": 208089, + "image_name": "9347.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1210.116, + 1657.21, + 311.24800000000005, + 236.56500000000005 + ], + "priority": 8, + "parents": [ + 193996 + ], + "children": [], + "area": 2005416.33636, + "iscrowd": 0, + "segmentation": [], + "text": "Flow-trough cell with\nSAW chip (5 sensor\nelements) and\nschematic\nmeandering\n\nflow profile" + }, + { + "id": 194003, + "strid": "7cef4e24-db9f-4862-8012-5997f0a49bfc", + "image_id": 208089, + "image_name": "9347.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 236.885, + 2080.973, + 1389.744, + 170.39300000000003 + ], + "priority": 9, + "parents": [ + 193996 + ], + "children": [], + "area": 492951.289105, + "iscrowd": 0, + "segmentation": [], + "text": "Self-assembled monolayers (SAM) of alkanethiol derivatives were\nprepared on gold surfaces leading to non-fouling and hydrophilic\nproperties, due to attached polyethylene glycol (PEG) residues." + }, + { + "id": 194004, + "strid": "27283c03-ed85-4b35-9298-63e5ad98784b", + "image_id": 208089, + "image_name": "9347.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 255.79, + 2325.509, + 1358.296, + 611.5190000000002 + ], + "priority": 10, + "parents": [ + 193996 + ], + "children": [], + "area": 594841.94711, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 194005, + "strid": "4f6e42a4-3b58-4cf3-83c1-36aa18e42927", + "image_id": 208089, + "image_name": "9347.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 245.35, + 2999.834, + 1391.124, + 113.25599999999986 + ], + "priority": 11, + "parents": [ + 193996 + ], + "children": [], + "area": 736009.2718999999, + "iscrowd": 0, + "segmentation": [], + "text": "Terminal amino groups were functionalized with trinitrophenyl| (TNP)\ngroups by reaction with trinitrobenzene sulfonic acid (TNBS)." + }, + { + "id": 194006, + "strid": "fa1a3c7e-79fc-4877-af29-3fb2162ecfd6", + "image_id": 208089, + "image_name": "9347.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 233.505, + 3170.431, + 1327.005, + 166.73700000000008 + ], + "priority": 12, + "parents": [ + 193996 + ], + "children": [], + "area": 740311.490655, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 194007, + "strid": "606fda9c-d20c-4fda-b4df-ebf1e5be4ea5", + "image_id": 208089, + "image_name": "9347.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 234.042, + 3472.301, + 1352.56, + 284.6619999999998 + ], + "priority": 13, + "parents": [ + 193996 + ], + "children": [], + "area": 812664.270642, + "iscrowd": 0, + "segmentation": [], + "text": "A continuous flow of butter (phosphate-bufttered saline, PBS plus\nTween 20) of 100 L/min was applied to the sensor system.\n\nTNT antibodies were pre-incubated with the samples containing\ntraces of explosives. Polyclonal and monoclonal antibodies were\ntested." + }, + { + "id": 194008, + "strid": "4fbe43f0-84cc-4ec9-9b0c-5e2ada41229e", + "image_id": 208089, + "image_name": "9347.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 233.283, + 3822.52, + 1387.191, + 885.105 + ], + "priority": 14, + "parents": [ + 193996 + ], + "children": [], + "area": 891728.9331599999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 193997, + "strid": "fb8add78-a293-4f3a-afef-4465868771e4", + "image_id": 208089, + "image_name": "9347.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1711.17, + 827.955, + 276.336, + 66.12099999999998 + ], + "priority": 15, + "parents": [ + 194018 + ], + "children": [ + 194009, + 194013, + 194012, + 194010, + 194011, + 194014 + ], + "area": 1416771.75735, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 194009, + "strid": "89bd8667-c0e9-450d-98d2-0182daac68ba", + "image_id": 208089, + "image_name": "9347.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1705.915, + 934.838, + 1395.2669999999998, + 369.36699999999996 + ], + "priority": 16, + "parents": [ + 193997 + ], + "children": [], + "area": 1594754.16677, + "iscrowd": 0, + "segmentation": [], + "text": "In less than 1 minute, a good signal response was obtained. 50 uL of\nSample was used. No non-specific interaction with the SAM surface\nwas observed. A complete measuring cycle needed 19 minutes\nincluding a surface regeneration step with 50 uL of aceto-\nnitrile/water/propionic acid (50:50:1) and 150 uL of SDS solution\n\n(0.1%, pH1with100 mM glycine and100 mM NaCl)." + }, + { + "id": 194010, + "strid": "84019802-4bee-45a2-ba22-69d35398cfff", + "image_id": 208089, + "image_name": "9347.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1719.28, + 1384.78, + 1377.171, + 421.7259999999999 + ], + "priority": 17, + "parents": [ + 193997 + ], + "children": [], + "area": 2380824.5584, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 194011, + "strid": "74a2b5a3-2fd6-454a-bc00-eabe3fc9ddb6", + "image_id": 208089, + "image_name": "9347.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1708.191, + 1952.022, + 1390.209, + 171.86400000000003 + ], + "priority": 18, + "parents": [ + 193997 + ], + "children": [], + "area": 3334426.412202, + "iscrowd": 0, + "segmentation": [], + "text": "A good long-term stability could be shown for at least 6 hours. Two\npolyclonal antibodies (R1, R2, affinity purified with Protein A) and a\nmonoclonal antibody (A1.1.1) were tested successfully." + }, + { + "id": 194012, + "strid": "c8537da8-dc98-4374-a2c6-fa7da28251b3", + "image_id": 208089, + "image_name": "9347.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1685.056, + 2142.547, + 1393.0139999999997, + 622.7080000000001 + ], + "priority": 19, + "parents": [ + 193997 + ], + "children": [], + "area": 3610311.6776320003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 194014, + "strid": "6af7dad5-93fd-437d-bee2-a6793e7df67d", + "image_id": 208089, + "image_name": "9347.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1705.567, + 2809.313, + 1285.8519999999999, + 108.45899999999983 + ], + "priority": 20, + "parents": [ + 193997 + ], + "children": [], + "area": 4791471.5454710005, + "iscrowd": 0, + "segmentation": [], + "text": "The limit of detection (LOD) was determined to 0.5 pg/L for all\nthree antibodies (3s from 12 replicates)." + }, + { + "id": 194013, + "strid": "137c832c-0e2b-4442-9a6e-e3969903b177", + "image_id": 208089, + "image_name": "9347.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1709.532, + 2970.885, + 1246.678, + 486.15499999999975 + ], + "priority": 21, + "parents": [ + 193997 + ], + "children": [], + "area": 5078822.97582, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 193998, + "strid": "d0ba2bce-849a-4121-add3-9f52bc4a0ee4", + "image_id": 208089, + "image_name": "9347.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1708.979, + 3552.407, + 442.46299999999997, + 65.7489999999998 + ], + "priority": 22, + "parents": [ + 194018 + ], + "children": [ + 194015 + ], + "area": 6070988.962453, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 194015, + "strid": "25414f43-7a63-4852-9b2e-09c54522fc1c", + "image_id": 208089, + "image_name": "9347.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1706.819, + 3666.015, + 1394.8849999999998, + 537.6650000000004 + ], + "priority": 23, + "parents": [ + 193998 + ], + "children": [], + "area": 6257224.0562849995, + "iscrowd": 0, + "segmentation": [], + "text": "A robust and sensitive method Tor the detection of the explosive\ntrinitrotoluene (TNT) was developed. The detection limit was\ndetermined to be around 0.5 pg/L. The fast signal response of less\nthan 1 minute shows that this approach is suitable for security and\nother time-critical applications. In addition, the very low cross-\nreactivity highly reduces the number of false-positives in relation to\ncompeting techniques, including sniffer dogs. Due to the\nmultianalyte ability of the SAW system, several explosives might be\ndetected in parallel." + }, + { + "id": 194016, + "strid": "14847b05-0959-4923-b399-ad6f1646ab77", + "image_id": 208089, + "image_name": "9347.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1710.838, + 4299.871, + 418.26700000000005, + 65.92900000000009 + ], + "priority": 24, + "parents": [ + 194018 + ], + "children": [ + 194017 + ], + "area": 7356382.701898, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 194017, + "strid": "2f91ca4a-8960-46a6-ac9a-dab7490e890f", + "image_id": 208089, + "image_name": "9347.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1706.758, + 4409.764, + 1364.133, + 117.01299999999992 + ], + "priority": 25, + "parents": [ + 194016 + ], + "children": [], + "area": 7526399.985112, + "iscrowd": 0, + "segmentation": [], + "text": "S. Ramin, M. G. Weller; Extremely sensitive and selective antibodies against the explosive 2,4,6-trinitrotoluene\nby rational design of a structurally optimized hapten, J. Molecular Recognit. 25 (2012) 89-97.\nhttp://www.ncbi.nim.nih.gov/pubmed/22290770" + }, + { + "id": 72181, + "strid": "67928c47-7e3f-41cf-ab37-99daae37b9d7", + "image_id": 203315, + "image_name": "120039.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 44.98, + 148.98, + 187.73000000000002, + 228.79 + ], + "priority": -1, + "parents": [], + "children": [ + 72176, + 72180, + 72157, + 72178, + 72163, + 72179, + 72161, + 72177, + 72162, + 72160, + 72159, + 72158 + ], + "area": 6701.120399999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 72157, + "strid": "3f9b9b9c-8e2c-48d8-bc80-aca9c7cd13c4", + "image_id": 203315, + "image_name": "120039.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 286.449, + 68.079, + 2571.925, + 250.483 + ], + "priority": 1, + "parents": [ + 72181 + ], + "children": [], + "area": 19501.161471, + "iscrowd": 0, + "segmentation": [], + "text": "Topologically Centralized White-Matter Structural\n) Connections in the Human Brain Networks (" + }, + { + "id": 72158, + "strid": "a2e009d1-dd92-4eb5-9ee8-a90b1592554a", + "image_id": 203315, + "image_name": "120039.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 405.564, + 403.298, + 2338.65, + 162.62300000000005 + ], + "priority": 2, + "parents": [ + 72181 + ], + "children": [], + "area": 163563.15007200002, + "iscrowd": 0, + "segmentation": [], + "text": "Mingrui Xia, Qixiang Lin??, Yanchao Bi+?, and Yong He?\n\n1State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China\n2Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, China" + }, + { + "id": 72159, + "strid": "5442ed20-9608-45fa-96eb-9f2bea48e4dd", + "image_id": 203315, + "image_name": "120039.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 34.778, + 721.076, + 317.731, + 52.35799999999995 + ], + "priority": 3, + "parents": [ + 72181 + ], + "children": [ + 72164 + ], + "area": 25077.581128, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 72164, + "strid": "89cc8bb4-26ca-45b0-8513-de619b9f6fd1", + "image_id": 203315, + "image_name": "120039.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 33.07, + 810.171, + 3053.229, + 291.865 + ], + "priority": 4, + "parents": [ + 72159 + ], + "children": [], + "area": 26792.35497, + "iscrowd": 0, + "segmentation": [], + "text": "In the human brain, white-matter (WM) structural connectivity linking neuronal elements form anatomical substrates underlying human cognitive functions [1]. Diffusion\nMRI (dMRI) data allow non-invasive reconstruction of the whole-brain WM networks at a macro-scale [2,3]. Nodes and edges are the most fundamental elements of the\nWM networks and their wiring patterns determine the brain’s topological principles, including small-worldness, modular organization and rich-club structure [4]. The\npivotal nodes (i.e., hubs) of the WM networks have been identified to be primarily in the medial and lateral frontal and parietal cortices and are closely associated with\nmetabolism [4], cognition [5] and the diseases [6]. However, the pivotal edges and their topological properties in the human WM networks remain largely unknown." + }, + { + "id": 72160, + "strid": "cedf2c0a-2d37-418c-88d5-b6d8eedc2f07", + "image_id": 203315, + "image_name": "120039.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 34.571, + 1165.959, + 231.16800000000003, + 51.70900000000006 + ], + "priority": 5, + "parents": [ + 72181 + ], + "children": [ + 72166, + 72165, + 72167 + ], + "area": 40308.368589, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 72165, + "strid": "5520d895-5cf8-4c76-839a-e8c2e1cfa16f", + "image_id": 203315, + "image_name": "120039.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 30.334, + 1256.12, + 1714.453, + 352.09899999999993 + ], + "priority": 6, + "parents": [ + 72160 + ], + "children": [], + "area": 38103.14408, + "iscrowd": 0, + "segmentation": [], + "text": "Data acquisition and preprocessing. This study included 57 young healthy volunteers from the\nCoRR database (http://fcon_1000.projects.nitrc.org/indi/CoRR/html/samples.html). dMRI data\nwere acquired from a SIEMENS Trio 3T scanner using the following parameters: TR/TE =\n8000/89ms, 30 directions with b = 1000 s/mm2, isotropic voxels size (2.2 mm3). Routine data\npreprocessing procedure was carried out using FSL, including the head motion and eddy\ncurrents corrections. All subjects completed a second scan after an interval of 40 days." + }, + { + "id": 72166, + "strid": "9372c00d-6ef9-436b-afda-cd30d2ea4230", + "image_id": 203315, + "image_name": "120039.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 31.458, + 1631.818, + 1713.623, + 294.74299999999994 + ], + "priority": 7, + "parents": [ + 72160 + ], + "children": [], + "area": 51333.730643999996, + "iscrowd": 0, + "segmentation": [], + "text": "Whole-brain WM network construction. We employed the AAL atlas [7] to parcellate the\ncerebrum into 90 regions. Reconstruction of the whole brain WM tracts was performed based\non the FACT algorithm [8]. For details of individual WM network construction, see [3]. A group-\nlevel connectivity matrix was computed by selecting all connections that were present in at\nleast 50% of the individuals (see Fig. 1 for flowchart)." + }, + { + "id": 72167, + "strid": "7bccce89-ee4c-43c8-8915-c32311071a32", + "image_id": 203315, + "image_name": "120039.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 31.214, + 1955.35, + 1720.722, + 660.7730000000001 + ], + "priority": 8, + "parents": [ + 72160 + ], + "children": [], + "area": 61034.29489999999, + "iscrowd": 0, + "segmentation": [], + "text": "Network analysis. The edge betweenness centrality (EBC) was used to quantify the\ncommunication capability of the edges in the WM network. We first estimated the EBC\ndistribution and identified the edges with high EBC (>mean + SD) as pivotal edges. We then\ncarried out a series of analyses to characterize their properties: i) compared the pivotal edges\nto non-pivotal ones on the fiber length and fiber integrity including fractional anisotropy (FA),\nmean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD); ii) examined the roles of\nthe pivotal edges in the rich-club structure [9] by comparing the distributions of pivotal edges\nin different categories of connections: rich-club, feeder and local connections; iii) examined the\npath motifs of the whole-brain anatomical network and their distribution across brain lobes; iv)\ntested the vulnerability of the edges using a “lesion” simulation analysis; and v) validated our\nfindings repeating all the analyses on the data of session 2." + }, + { + "id": 72161, + "strid": "c0f9e39f-d487-4596-8fb1-b83c665ac1fa", + "image_id": 203315, + "image_name": "120039.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1799.689, + 1164.432, + 184.64300000000003, + 51.43399999999997 + ], + "priority": 9, + "parents": [ + 72181 + ], + "children": [ + 72168 + ], + "area": 2095615.4616480002, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 72168, + "strid": "8ac91a6d-8dde-4155-8e1c-6f53be8d4d44", + "image_id": 203315, + "image_name": "120039.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1793.264, + 1255.206, + 1318.5980000000002, + 1353.845 + ], + "priority": 10, + "parents": [ + 72161 + ], + "children": [], + "area": 2250915.7323839995, + "iscrowd": 0, + "segmentation": [], + "text": "The whole-brain WM network had a connection density of 10.8%. The\nEBC distribution of the network was best fitted by the exponentially\ntruncated power-law form rather than the power-law model (Fig. 2).\n\nForty-eight of the total 431 edges were identified as pivotal edges,\nincluding 16 inter-hemispheric and 32 intra-hemispheric connections\n(Fig. 2), most of which were associated with several major WM tracts\ninvolving the corpus callosum, the cingulum, and the uncinate fasciculus.\n\nCompared to non-pivotal edges, the pivotal edges were significantly\nlonger (mean fiber length: 69.2 mm vs. 42.6 mm, p<0.0001) and had\nhigher level of fiber integrity (FA, MD and AD; all ps<0.0004) (Fig. 2).\nThe pivotal edges occurred more often in rich-club connections (rich\nclub vs. feeder vs. local: 57.1% vs. 19.7% vs. 3.0%; p<0.0001) (Fig. 5).\nThe paths in the brain network exhibited significantly greater\npercentages of the pivotal edge related connections (e.g., ‘P’,‘N-P’, ‘N-P-\nN’, and ‘N-P-N-P’, all Zs > 4.4) than those in the random network. The\npath motifs differed across brain lobes (Fig. 4 & 5).\n\nLesion simulations revealed that the WM network was more vulnerable\nto the elimination of the pivotal edges than non-pivotal edges\n(p<0.0001) (Fig. 3).\n\nAll results from the data of session 2 were highly similar to those in the\n\n \n\nfirst scan." + }, + { + "id": 72176, + "strid": "303e73d3-2153-47c8-84cb-7ff872012624", + "image_id": 203315, + "image_name": "120039.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 46.198, + 2756.469, + 989.833, + 1155.7200000000003 + ], + "priority": 11, + "parents": [ + 72181 + ], + "children": [ + 72170 + ], + "area": 127343.35486200001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 72170, + "strid": "854ee815-1ce8-4756-9e29-07673c30173a", + "image_id": 203315, + "image_name": "120039.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 195.957, + 2681.557, + 685.445, + 61.128000000000156 + ], + "priority": 12, + "parents": [ + 72176 + ], + "children": [], + "area": 525469.8650489999, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 1 Flowchart of analysis" + }, + { + "id": 72179, + "strid": "01664a09-0d98-42cf-9079-098e77077a90", + "image_id": 203315, + "image_name": "120039.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 43.075, + 4037.746, + 997.5159999999998, + 1038.6989999999996 + ], + "priority": 13, + "parents": [ + 72181 + ], + "children": [ + 72174 + ], + "area": 173925.90895, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 72174, + "strid": "7960758b-5ded-4a41-b08d-3ccf3bcafd3a", + "image_id": 203315, + "image_name": "120039.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 227.928, + 3957.852, + 606.267, + 59.13500000000022 + ], + "priority": 14, + "parents": [ + 72179 + ], + "children": [], + "area": 902105.2906559999, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 2 Pivotal WM edges" + }, + { + "id": 72177, + "strid": "e55bf145-e3e8-4efd-b0ce-b325c4221c65", + "image_id": 203315, + "image_name": "120039.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1077.138, + 2762.394, + 993.1010000000001, + 1144.6460000000002 + ], + "priority": 15, + "parents": [ + 72181 + ], + "children": [ + 72171 + ], + "area": 2975479.5483719995, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 72171, + "strid": "bb7a640e-4ae5-457f-9caf-df438a15dbee", + "image_id": 203315, + "image_name": "120039.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1178.411, + 2682.079, + 772.836, + 57.91100000000006 + ], + "priority": 16, + "parents": [ + 72177 + ], + "children": [], + "area": 3160591.3964690003, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 3 Pivotal edges in rich club" + }, + { + "id": 72180, + "strid": "d46348af-e911-4223-9d44-fdd5c7c4e81d", + "image_id": 203315, + "image_name": "120039.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1116.854, + 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"id": 72172, + "strid": "d783d3fc-26a6-42cd-b49a-13e3a5ddfd23", + "image_id": 203315, + "image_name": "120039.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2151.499, + 2681.431, + 905.8989999999999, + 56.79800000000023 + ], + "priority": 20, + "parents": [ + 72178 + ], + "children": [], + "area": 5769096.115068999, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 5 Path motifs across brain lobes" + }, + { + "id": 72162, + "strid": "cbd2686f-1ade-4afb-bd7e-4bba91fa7e3c", + "image_id": 203315, + "image_name": "120039.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1732.603, + 4147.87, + 278.35400000000004, + 50.91899999999987 + ], + "priority": 21, + "parents": [ + 72181 + ], + "children": [ + 72169 + ], + "area": 7186612.00561, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion" + }, + { + "id": 72169, + "strid": "f8beb504-511c-4da9-9acf-fc700800cd11", + "image_id": 203315, + "image_name": "120039.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1729.048, + 4237.332, + 1337.8860000000002, + 289.2600000000002 + ], + "priority": 22, + "parents": [ + 72162 + ], + "children": [], + "area": 7326550.419936, + "iscrowd": 0, + "segmentation": [], + "text": "This study mapped out the pivotal edges of the human whole-brain WM\nnetwork and depicted the basic physical and topological characteristics of\nthese edges, demonstrating their unusual constitution and critical role as\nthe main skeleton in the organization principles of the human brain\nstructural networks." + }, + { + "id": 72163, + "strid": "ade32462-d823-4636-a54f-9dcf672cb877", + "image_id": 203315, + "image_name": "120039.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1733.638, + 4575.0, + 280.355, + 51.09299999999985 + ], + "priority": 23, + "parents": [ + 72181 + ], + "children": [ + 72175 + ], + "area": 7931393.85, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 72175, + "strid": "32463bb9-1008-4552-84c9-eef03be5bf16", + "image_id": 203315, + "image_name": "120039.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1730.964, + 4639.551, + 1345.4499999999998, + 420.10300000000007 + ], + "priority": 24, + "parents": [ + 72163 + ], + "children": [], + "area": 8030895.7571640005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 28542, + "strid": "370f61d7-8e2f-4d16-ab65-fde038c39745", + "image_id": 201626, + "image_name": "117415.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 244.07, + 95.6, + 290.94, + 273.83000000000004 + ], + "priority": -1, + "parents": [], + "children": [ + 28517, + 28519, + 28521, + 28540, + 28522, + 28523, + 28520, + 28518 + ], + "area": 23333.091999999997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 28517, + "strid": "837c2f77-d96a-4c78-82ef-beca42589c19", + "image_id": 201626, + "image_name": "117415.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 807.179, + 149.788, + 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"Section", + "bbox": [ + 449.89, + 721.032, + 725.0370000000001, + 85.57000000000005 + ], + "priority": 3, + "parents": [ + 28542 + ], + "children": [ + 28526 + ], + "area": 324385.08648, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 28526, + "strid": "bc6ced10-0b5e-4263-a5bf-5e620b00a59e", + "image_id": 201626, + "image_name": "117415.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 80.978, + 872.913, + 1438.694, + 233.40699999999993 + ], + "priority": 4, + "parents": [ + 28519 + ], + "children": [], + "area": 70686.748914, + "iscrowd": 0, + "segmentation": [], + "text": "Chronic complications of diabetes are associated with platelets\nabnormalities. Many studies reported alterations in platelets function\nand morphology, but data on this issue in children with type 1 diabetes\n(T1DM) are lacking." + }, + { + "id": 28520, + "strid": "79cc639d-7732-4570-b755-0a5b81eaeb48", + "image_id": 201626, + "image_name": "117415.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 678.293, + 1162.502, + 249.76, + 86.65100000000007 + ], + "priority": 5, + "parents": [ + 28542 + ], + "children": [ + 28527 + ], + "area": 788516.969086, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 28527, + "strid": "6626c2f8-f472-4218-b8ec-b1fe23f6f7a1", + "image_id": 201626, + "image_name": "117415.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 93.276, + 1294.812, + 1453.503, + 171.40599999999995 + ], + "priority": 6, + "parents": [ + 28520 + ], + "children": [], + "area": 120774.88411199999, + "iscrowd": 0, + "segmentation": [], + "text": "The aim of this study was to compare platelet parameters between\nchildren with T1DM and healthy controls and determine the influence\nof metabolic control on platelet morphology." + }, + { + "id": 28522, + "strid": "7a1bdcc9-c3c3-41a2-b823-ba3e6596c3fb", + "image_id": 201626, + "image_name": "117415.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 584.373, + 1523.563, + 474.068, + 86.13000000000011 + ], + "priority": 7, + "parents": [ + 28542 + ], + "children": [ + 28530, + 28529 + ], + "area": 890329.0809990001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 28529, + "strid": "5bd30aae-1b5a-4c8e-a52a-b7295ad64b3e", + "image_id": 201626, + "image_name": "117415.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 102.28, + 1664.401, + 733.368, + 579.5449999999998 + ], + "priority": 8, + "parents": [ + 28522 + ], + "children": [], + "area": 170234.93428000002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 28530, + "strid": "7605a8bf-9511-4b9a-bf45-8ee0e2cb43f5", + "image_id": 201626, + "image_name": "117415.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 874.329, + 1666.245, + 738.3790000000001, + 830.5569999999998 + ], + "priority": 9, + "parents": [ + 28522 + ], + "children": [], + "area": 1456846.3246049997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 28523, + "strid": "9599a5f5-07e1-4c6c-9067-6ec7aa45e301", + "image_id": 201626, + "image_name": "117415.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 672.226, + 2565.238, + 381.82499999999993, + 84.30600000000004 + ], + "priority": 10, + "parents": [ + 28542 + ], + "children": [ + 28532, + 28537, + 28539, + 28531 + ], + "area": 1724419.679788, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 28537, + "strid": "a06f1841-00b2-444a-9fcb-5ecdb964d688", + "image_id": 201626, + "image_name": "117415.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 88.162, + 2727.176, + 851.553, + 640.1839999999997 + ], + "priority": 11, + "parents": [ + 28523 + ], + "children": [ + 28536 + ], + "area": 240433.290512, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 28536, + "strid": "78c2fc77-da34-4071-8b5e-ad471f9f4e79", + "image_id": 201626, + "image_name": "117415.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 102.003, + 3404.759, + 1016.1639999999999, + 109.65599999999995 + ], + "priority": 12, + "parents": [ + 28537 + ], + "children": [], + "area": 347295.632277, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. Sex distibution in the study population\n(blue bars —study group, red bars — control group)." + }, + { + "id": 28531, + "strid": "a80bc386-ce25-491d-8a7d-ec4a69bc888c", + "image_id": 201626, + "image_name": "117415.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 952.705, + 2725.016, + 539.3749999999999, + 228.80200000000013 + ], + "priority": 13, + "parents": [ + 28523 + ], + "children": [], + "area": 2596136.36828, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 28532, + "strid": "0b1dcfd0-8ba7-4e7d-9701-f08cb326899a", + "image_id": 201626, + "image_name": "117415.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 959.136, + 3023.397, + 585.883, + 290.19900000000007 + ], + "priority": 14, + "parents": [ + 28523 + ], + "children": [], + "area": 2899848.9049919997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 28539, + "strid": "bcc02bc5-6bf3-4291-b4d7-9a2635493152", + "image_id": 201626, + "image_name": "117415.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 22.331, + 3580.215, + 1561.63, + 789.1409999999996 + ], + "priority": 15, + "parents": [ + 28523 + ], + "children": [ + 28538 + ], + "area": 79949.78116500001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 28538, + "strid": "101e29a8-3237-45ef-b67b-8fe271035fd5", + "image_id": 201626, + "image_name": "117415.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 41.357, + 4408.72, + 1598.348, + 52.021999999999935 + ], + "priority": 16, + "parents": [ + 28539 + ], + "children": [], + "area": 182331.43304, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1 - Analysis between groups before and after adjustment for age and sex." + }, + { + "id": 28521, + "strid": "3fe4a479-2a3d-4d59-8b92-e0d7c8fa8cf1", + "image_id": 201626, + "image_name": "117415.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2248.276, + 719.707, + 388.55499999999984, + 87.83699999999999 + ], + "priority": 17, + "parents": [ + 28542 + ], + "children": [ + 28525, + 28533, + 28528, + 28524 + ], + "area": 1618099.975132, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 28524, + "strid": "a089c614-460e-4e48-b361-16abd2b49469", + "image_id": 201626, + "image_name": "117415.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1717.875, + 877.124, + 1127.3810000000003, + 845.733 + ], + "priority": 18, + "parents": [ + 28521 + ], + "children": [ + 28534 + ], + "area": 1506789.3915000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 28534, + "strid": "655b3304-b62d-41ab-a46d-19440975eaf4", + "image_id": 201626, + "image_name": "117415.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1713.633, + 1757.537, + 1453.8640000000003, + 105.32400000000007 + ], + "priority": 19, + "parents": [ + 28524 + ], + "children": [], + "area": 3011773.4019210003, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2. The corelation between HbA1c and platelet count in the group\nof patients with T1DM." + }, + { + "id": 28528, + "strid": "ed3dca11-e14f-4c5e-b7ad-c26cd2dd7784", + "image_id": 201626, + "image_name": "117415.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2885.344, + 890.88, + 402.6869999999999, + 583.814 + ], + "priority": 20, + "parents": [ + 28521 + ], + "children": [], + "area": 2570495.26272, + "iscrowd": 0, + "segmentation": [], + "text": "Among children\nwith diabetes a\nsignificant\ncorrelation\nbetween metabolic\ncontrol measured\nby HbA1c and\nplatelet count\n(r=0.12, p=0.0143)\nwas found." + }, + { + "id": 28525, + "strid": "9641c226-39bc-4949-9ddb-814ef187e164", + "image_id": 201626, + "image_name": "117415.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1655.185, + 1915.847, + 1498.4500000000003, + 825.5979999999997 + ], + "priority": 21, + "parents": [ + 28521 + ], + "children": [ + 28535 + ], + "area": 3171081.216695, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 28535, + "strid": "814c7213-eb32-421e-9701-a57bc9822299", + "image_id": 201626, + "image_name": "117415.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1652.975, + 2778.153, + 1548.1460000000002, + 182.4079999999999 + ], + "priority": 22, + "parents": [ + 28525 + ], + "children": [], + "area": 4592217.455174999, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3. Seasonal variability of HbA1c - in multivariate analysis season of\nstudy was found to be an independent factor factors associated with HbA1c\n(B..ino=(-0.03), B =(-0.04), B =(0.05), p=0.0473) .\n\nspring summer winter" + }, + { + "id": 28533, + "strid": "93e3e08d-278e-42fe-8f19-924567b421c5", + "image_id": 201626, + "image_name": "117415.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1642.993, + 3026.111, + 1614.5390000000002, + 700.2449999999999 + ], + "priority": 23, + "parents": [ + 28521 + ], + "children": [], + "area": 4971879.190223, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 28540, + "strid": "9a077d8c-165c-4c8c-9440-f929895246b4", + "image_id": 201626, + "image_name": "117415.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2108.31, + 3837.43, + 673.5050000000001, + 88.01800000000003 + ], + "priority": 24, + "parents": [ + 28542 + ], + "children": [ + 28541 + ], + "area": 8090492.043299999, + "iscrowd": 0, + "segmentation": 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"Title", + "bbox": [ + 1005.849, + 74.971, + 2580.578, + 128.274 + ], + "priority": 1, + "parents": [ + 78115 + ], + "children": [], + "area": 75409.50537900001, + "iscrowd": 0, + "segmentation": [], + "text": "Gene finding’ in metatranscriptomic sequences" + }, + { + "id": 78083, + "strid": "5a32c627-53d1-4a6d-a8d8-97623c46b8ff", + "image_id": 203547, + "image_name": "120450.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1475.584, + 220.052, + 1638.6900000000003, + 155.025 + ], + "priority": 2, + "parents": [ + 78115 + ], + "children": [], + "area": 324705.21036800003, + "iscrowd": 0, + "segmentation": [], + "text": "Wazim Mohammed Ismail, Yuzhen Ye and Haixu Tang\n\nSchool of Informatics and Computing/Indiana University, Bloomington" + }, + { + "id": 78084, + "strid": "17b0d57d-58a6-4666-ab2a-821f898d40cd", + "image_id": 203547, + "image_name": "120450.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 441.529, + 561.867, + 348.581, + 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"Current metatfanscriptomic studies adopt the\nstranded RNA-Seq protocol [1], which facilitates si-\nmultaneous’ prediction of" + }, + { + "id": 78101, + "strid": "72fe73e2-0f9a-4081-8cbd-a57c67c6afac", + "image_id": 203547, + "image_name": "120450.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 107.391, + 1580.417, + 1017.9020000000002, + 254.17799999999988 + ], + "priority": 6, + "parents": [ + 78084 + ], + "children": [], + "area": 169722.562047, + "iscrowd": 0, + "segmentation": [], + "text": "(i) Qperon:\nRonctional unit of genomic DNA containing cluster\nof genes under the control of a singlesregulatory\n\nregion (promoter)." + }, + { + "id": 78096, + "strid": "236bd8c1-bf22-4d18-8289-2a69cce7fd2c", + "image_id": 203547, + "image_name": "120450.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 291.6, + 1865.781, + 687.917, + 369.1579999999999 + ], + "priority": 7, + "parents": [ + 78084 + ], + "children": [], + "area": 544061.7396, + 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"image_id": 203547, + "image_name": "120450.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 196.299, + 2861.373, + 838.6190000000001, + 541.0639999999999 + ], + "priority": 10, + "parents": [ + 78084 + ], + "children": [], + "area": 561684.658527, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 78085, + "strid": "1dd09ef8-5573-4b09-a301-45b54a5c56aa", + "image_id": 203547, + "image_name": "120450.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1953.652, + 561.331, + 690.1219999999998, + 49.186000000000035 + ], + "priority": 11, + "parents": [ + 78115 + ], + "children": [ + 78094, + 78105, + 78111, + 78095 + ], + "area": 1096645.430812, + "iscrowd": 0, + "segmentation": [], + "text": "Hid@en Markov Models" + }, + { + "id": 78111, + "strid": "6706a762-f281-4f73-82d1-f51d0c3881fc", + "image_id": 203547, + "image_name": "120450.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1228.198, + 689.943, + 2144.831, + 173.01 + ], + "priority": 12, + "parents": [ + 78085 + ], + "children": [], + "area": 847386.612714, + "iscrowd": 0, + "segmentation": [], + "text": "We developed a Hidden Markov Model,’TransGeneScan |2} HMM, specifically designed for metatranscriptomic\nsequences. The probabilistic m6délramework is partially adopted from FragGeneScan [3], a gene finder for\nmetagenomic sequences which handles short and error-prone reads." + }, + { + "id": 78094, + "strid": "b55b779e-781d-4521-a654-52cc1afa6203", + "image_id": 203547, + "image_name": "120450.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1231.879, + 893.03, + 1018.3699999999999, + 1069.351 + ], + "priority": 13, + "parents": [ + 78085 + ], + "children": [], + "area": 1100104.90337, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 78095, + "strid": "d086fa98-1e58-4850-bd76-29c2cc462211", + "image_id": 203547, + "image_name": "120450.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2366.503, + 1082.721, + 1005.8800000000001, + 698.2449999999999 + ], + "priority": 14, + "parents": [ + 78085 + ], + "children": [], + "area": 2562262.494663, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 78105, + "strid": "2242c96d-565d-49f9-a1a3-14c1f1e57364", + "image_id": 203547, + "image_name": "120450.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1259.95, + 2134.363, + 2087.8450000000003, + 112.35500000000002 + ], + "priority": 15, + "parents": [ + 78085 + ], + "children": [], + "area": 2689190.66185, + "iscrowd": 0, + "segmentation": [], + "text": "By.incorporating features specific to metatrangeriptomic sequencing, like strand-specifieity and short\nmtergenic regions, TransGeneScan can predict@enes, operons and asRNA in metatranscriptome assemblies." + }, + { + "id": 78091, + "strid": "74eabfd1-287a-4410-97da-ed565a568a08", + "image_id": 203547, + "image_name": "120450.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1626.883, + 2357.479, + 222.76700000000005, + 46.53200000000015 + ], + "priority": 16, + "parents": [ + 78115 + ], + "children": [ + 78107, + 78106 + ], + "area": 3835342.507957, + "iscrowd": 0, + "segmentation": [], + "text": "Dataset" + }, + { + "id": 78106, + "strid": "0f29ee0f-d2ab-4ded-a798-d4dc6d3e1283", + "image_id": 203547, + "image_name": "120450.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1227.981, + 2480.319, + 1019.262, + 112.2829999999999 + ], + "priority": 17, + "parents": [ + 78091 + ], + "children": [], + "area": 3045784.605939, + "iscrowd": 0, + "segmentation": [], + "text": "We analyzed RNA-seq reads fronyva mock bacterial\ncommunity containing three bacterial species:" + }, + { + "id": 78107, + "strid": "b5ffa92d-6694-45bd-8fef-de8cbb14b937", + "image_id": 203547, + "image_name": "120450.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1228.887, + 2622.869, + 548.721, + 188.44000000000005 + ], + "priority": 18, + "parents": [ + 78091 + ], + "children": [], + "area": 3223209.616803, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 78092, + "strid": "dd890666-28e8-4a64-a065-ec96709e9a62", + "image_id": 203547, + "image_name": "120450.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1411.017, + 2904.244, + 654.365, + 51.17099999999982 + ], + "priority": 19, + "parents": [ + 78115 + ], + "children": [ + 78103 + ], + "area": 4097937.656148, + "iscrowd": 0, + "segmentation": [], + "text": "formance measures" + }, + { + "id": 78103, + "strid": "67d34fde-f3f4-47c6-b2b2-8da138391f57", + "image_id": 203547, + "image_name": "120450.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1232.499, + 3041.382, + 1011.952, + 353.65099999999984 + ], + "priority": 20, + "parents": [ + 78092 + ], + "children": [], + "area": 3748500.273618, + "iscrowd": 0, + "segmentation": [], + "text": "# of true positives\nSensitivity (Sn) =\nensitivity (Sn) = # of annotated genes\n\nPrecision (Pr) = # of true positives\n# of predicted genes\n\n2x Preciston Sensitivity\n\n \n\nAccuracy (Ac) =\ny (Ac) Precision + Sensitivity" + }, + { + "id": 78090, + "strid": "7416bad6-0338-45f3-bb6a-90e23fc1a013", + "image_id": 203547, + "image_name": "120450.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2722.692, + 2359.356, + 277.46399999999994, + 58.378999999999905 + ], + "priority": 21, + "parents": [ + 78115 + ], + "children": [ + 78108, + 78104 + ], + "area": 6423799.706352001, + "iscrowd": 0, + "segmentation": [], + "text": "Asséinbly" + }, + { + "id": 78104, + "strid": "30cac0b0-ae9b-411a-8a4a-36179dc95329", + "image_id": 203547, + "image_name": "120450.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2351.369, + 2482.495, + 1019.2260000000001, + 292.8879999999999 + ], + "priority": 22, + "parents": [ + 78090 + ], + "children": [], + "area": 5837261.785655, + "iscrowd": 0, + "segmentation": [], + "text": "The reads could be‘assembled into transcripts using a\nreference-mapping based approach or using de novo\nassembly algorithms like Velvet, Trinity or Oases. In\norder to-evaluate the prediction against the referea¢e\ngenome annotation, we use the former method:" + }, + { + "id": 78108, + "strid": "88de21f0-ad54-4c9f-91a4-299d7dce9392", + "image_id": 203547, + "image_name": "120450.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2353.97, + 2811.018, + 1017.1150000000002, + 570.2550000000001 + ], + "priority": 23, + "parents": [ + 78090 + ], + "children": [], + "area": 6617052.041459999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 78086, + "strid": "5f3709e8-12dd-429b-9580-aebd86cc5051", + "image_id": 203547, + "image_name": "120450.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3876.575, + 563.841, + 213.29899999999998, + 45.5 + ], + "priority": 24, + "parents": [ + 78115 + ], + "children": [ + 78099, + 78112, + 78113 + ], + "area": 2185771.924575, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 78112, + "strid": "10deb3cf-bde9-46cd-b932-d5173d97cd97", + "image_id": 203547, + "image_name": "120450.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3470.681, + 682.329, + 1025.524, + 300.797 + ], + "priority": 25, + "parents": [ + 78086 + ], + "children": [], + "area": 2368146.2960489998, + "iscrowd": 0, + "segmentation": [], + "text": "The tablebelow shows gene prediction performance\nof Gen@Mark (GM), Glimmer (GI), MetaGeneMank\n(MGM), FragGeneScan (FGS) and TransGene$Scan\n(FGS) for Escherichia coli. * The number 6f positive\ngenes recovered in the assembled transefipts." + }, + { + "id": 78099, + "strid": "9a33222e-ba4d-4969-bb47-c9c6f1654ed4", + "image_id": 203547, + "image_name": "120450.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 3474.26, + 1045.038, + 1050.5439999999999, + 613.877 + ], + "priority": 26, + "parents": [ + 78086 + ], + "children": [], + "area": 3630733.72188, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 78113, + "strid": "b9d82b53-4239-48c0-8e06-ba775977fbfc", + "image_id": 203547, + "image_name": "120450.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3476.391, + 1697.159, + 980.9240000000004, + 121.54899999999998 + ], + "priority": 27, + "parents": [ + 78086 + ], + "children": [], + "area": 5899988.273169001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 78087, + "strid": "87355f41-1bae-49d0-af1b-42135e973f45", + "image_id": 203547, + "image_name": "120450.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3819.802, + 1915.342, + 327.29800000000023, + 57.962999999999965 + ], + "priority": 28, + "parents": [ + 78115 + ], + "children": [ + 78114 + ], + "area": 7316227.202284001, + "iscrowd": 0, + "segmentation": [], + "text": "Availability" + }, + { + "id": 78114, + "strid": "0d1c903c-612a-4cef-ad75-156c4a4d2ec3", + "image_id": 203547, + "image_name": "120450.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3475.796, + 2062.743, + 1044.3259999999996, + 201.73799999999983 + ], + "priority": 29, + "parents": [ + 78087 + ], + "children": [], + "area": 7169673.868427999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 78089, + "strid": "dd0d88e1-a92d-4666-a5d1-5abdc444df12", + "image_id": 203547, + "image_name": "120450.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3706.575, + 2978.235, + 550.6469999999999, + 59.91100000000006 + ], + "priority": 30, + "parents": [ + 78115 + ], + "children": [ + 78110 + ], + "area": 11039051.395125, + "iscrowd": 0, + "segmentation": [], + "text": "Acknéwtedgements" + }, + { + "id": 78110, + "strid": "5f356923-bb85-47f8-9f22-123bd9521606", + "image_id": 203547, + "image_name": "120450.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3468.468, + 3101.168, + 1029.138, + 144.27199999999993 + ], + "priority": 31, + "parents": [ + 78089 + ], + "children": [], + "area": 10756301.970624, + "iscrowd": 0, + "segmentation": [], + "text": "We are grateful ¢oyDr. Mina Rho for her support with FragGe-\nneScan. This work‘is supported by National Science Foundation\nunder grant(Gaumber DBI-0845685." + }, + { + "id": 78088, + "strid": "9d6f5de0-b0ed-4ae4-af5a-4421ae231776", + "image_id": 203547, + "image_name": "120450.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3826.71, + 2362.457, + 312.1790000000001, + 46.9409999999998 + ], + "priority": 32, + "parents": [ + 78115 + ], + "children": [ + 78109 + ], + "area": 9040437.826469999, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 78109, + "strid": "3a8e97dd-0760-49a8-b7a9-ed051e095cf6", + "image_id": 203547, + "image_name": "120450.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3476.884, + 2505.845, + 1021.924, + 401.78099999999995 + ], + "priority": 33, + "parents": [ + 78088 + ], + "children": [], + "area": 8712532.386979999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86981, + "strid": "b84ce6ee-e671-436e-ac71-c45888b106f2", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 303.36, + 47.98, + 127.41999999999996, + 150.58 + ], + "priority": -1, + "parents": [], + "children": [ + 86963, + 86943, + 86944, + 86945, + 86947, + 86946 + ], + "area": 14555.2128, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86944, + "strid": "d88577be-9326-41be-8075-d419b5c6c5dc", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 461.341, + 70.161, + 4314.837, + 202.63299999999998 + ], + "priority": 1, + "parents": [ + 86981 + ], + "children": [], + "area": 32368.145901, + "iscrowd": 0, + "segmentation": [], + "text": "Exploring alternative domain architectures as a way to improve annotation consistency within the\nConserved Domain Database (CDD) Conserved ae" + }, + { + "id": 86943, + "strid": "b92cadee-8f47-4336-89c6-5da2d2c7368e", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1126.232, + 308.489, + 2979.0560000000005, + 149.803 + ], + "priority": 2, + "parents": [ + 86981 + ], + "children": [], + "area": 347430.18344799994, + "iscrowd": 0, + "segmentation": [], + "text": "National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health\n\nMyra K. Derbyshire, Noreen Gonzales, Jane He, Shennan Lu, Josie Wang, Stephen H. Bryant, and Aron Marchler-Bauer." + }, + { + "id": 86945, + "strid": "3b4554d4-f9c3-4207-8226-eed342cdd47c", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 17.503, + 481.696, + 314.204, + 39.722999999999956 + ], + "priority": 3, + "parents": [ + 86981 + ], + "children": [ + 86956, + 86950, + 86951, + 86955, + 86957, + 86952, + 86948, + 86958, + 86954, + 86949, + 86953 + ], + "area": 8431.125088, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 86948, + "strid": "b5ff6786-d3ae-4948-8310-618366386d72", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 56.351, + 584.522, + 1374.7619999999997, + 367.241 + ], + "priority": 4, + "parents": [ + 86945 + ], + "children": [], + "area": 32938.399222, + "iscrowd": 0, + "segmentation": [], + "text": "CDD is a collection of protein domain models, collected as multiple\nsequence.alignments and converted into position-specific Score\nmatrices: It uses RPS-BLAST to match protein sequences with these\nmodels using a live search service for protein and nucleotide queries,\naswell as pre-computed (at a pre-set E-value) domain and site\nannotation for the majority of protein sequences tracked by NCBI’s\nEntrez system." + }, + { + "id": 86950, + "strid": "b9375249-cffc-4e04-8510-3eb3ca6c4104", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 117.776, + 987.455, + 474.30299999999994, + 356.71899999999994 + ], + "priority": 5, + "parents": [ + 86945 + ], + "children": [], + "area": 116298.50008, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86949, + "strid": "a31ea0d1-3f52-4568-9540-2d39c6c898bc", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 633.443, + 1011.333, + 769.2270000000001, + 205.53100000000006 + ], + "priority": 6, + "parents": [ + 86945 + ], + "children": [], + "area": 640621.809519, + "iscrowd": 0, + "segmentation": [], + "text": "NCBLCDD curation effort: fine-grained\nhierarchical classifications for selected\ndomain families, based on\nphylogenetic analysis" + }, + { + "id": 86951, + "strid": "15e45585-be2d-4c92-852b-df9d83f13e5f", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 31.553, + 1422.017, + 1453.103, + 319.019 + ], + "priority": 7, + "parents": [ + 86945 + ], + "children": [], + "area": 44868.902401, + "iscrowd": 0, + "segmentation": [], + "text": "CDART: Conserved Domain Architecture Retrieval Tool performs similarity,searches\nof Entrez Protein-based on domain architecture (DA, the sequential order of\nconserved/domains in protein queries). When CDART is queried.by protein\nsequence; itreturns the footprints of the highest scoring CDD superfamily(ies) found\nin that sequence, plus a list of proteins having similar DAs to.the query and grouped\naccording to DA. Output for each DA includes its taxonomy ‘span, and the number of\nNRsequences having that architecture ." + }, + { + "id": 86952, + "strid": "b9967f29-0bfd-4ffe-97bb-55b1f06f16c1", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 156.267, + 1763.341, + 765.8049999999998, + 493.47400000000016 + ], + "priority": 8, + "parents": [ + 86945 + ], + "children": [], + "area": 275552.008047, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86953, + "strid": "8ce65a6a-8944-4fca-a7dc-90a05c2f99cb", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 711.835, + 1791.706, + 664.558, + 310.0649999999998 + ], + "priority": 9, + "parents": [ + 86945 + ], + "children": [], + "area": 1275399.04051, + "iscrowd": 0, + "segmentation": [], + "text": "The significant fraction of DAs\nhavin a few NR sequences\nxplained by inconsistency\nannotation; reducing\nnsistencies would also reduce\ne number of potentially erroneous\nDAs in CDART." + }, + { + "id": 86954, + "strid": "2e5139fe-9882-47bd-a9b7-61383b5592b1", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 14.277, + 2357.438, + 701.932, + 50.733999999999924 + ], + "priority": 10, + "parents": [ + 86945 + ], + "children": [], + "area": 33657.142326, + "iscrowd": 0, + "segmentation": [], + "text": "We are investigating whether:" + }, + { + "id": 86955, + "strid": "c1632dcc-b606-464f-8fd0-cf186ddb546d", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 14.716, + 2441.525, + 1445.273, + 198.596 + ], + "priority": 11, + "parents": [ + 86945 + ], + "children": [], + "area": 35929.4819, + "iscrowd": 0, + "segmentation": [], + "text": "- collecting additional CDD-search-database hits obtained at a higher E-\nvalue threshold would uncover DAs that are common enough to provide a\nreasonable alternative to DAs assigned with the default RPS-BLAST E-\nvalue." + }, + { + "id": 86956, + "strid": "9bd79ec4-e6d2-437a-ad13-b018c034cb6e", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 79.9, + 2723.538, + 1108.354, + 730.1030000000001 + ], + "priority": 12, + "parents": [ + 86945 + ], + "children": [], + "area": 217610.68620000003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86957, + "strid": "050f3bcb-6318-4f4f-b1fc-fdfcdc4d9bbd", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1205.598, + 2748.935, + 296.87300000000005, + 678.344 + ], + "priority": 13, + "parents": [ + 86945 + ], + "children": [], + "area": 3314110.53813, + "iscrowd": 0, + "segmentation": [], + "text": "- suppressing\nsome CDD\nannotation\n(borderline\nhits) with E-\nvalues close to\nthe reporting\nthreshold\ncould be\neffective in\nremoving rare\nand unlikely\nDAs" + }, + { + "id": 86958, + "strid": "82920522-2a48-4c35-9746-6d76808b769a", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 6.699, + 3494.779, + 1464.241, + 79.78600000000006 + ], + "priority": 14, + "parents": [ + 86945 + ], + "children": [], + "area": 23411.524521, + "iscrowd": 0, + "segmentation": [], + "text": "This work was supported by the Intramural Research Program of the National Library\nof Medicine at National Institutes of Health/DHHS." + }, + { + "id": 86946, + "strid": "be38773c-d9ab-4e4e-9de3-097baa118ca2", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1585.399, + 481.178, + 213.8019999999999, + 41.073999999999955 + ], + "priority": 15, + "parents": [ + 86981 + ], + "children": [ + 86959, + 86961, + 86960 + ], + "area": 762859.1200219999, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 86959, + "strid": "0290be6a-005d-48e4-9c57-de55e42175c4", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1587.82, + 560.52, + 1591.5449999999998, + 630.1469999999999 + ], + "priority": 16, + "parents": [ + 86946 + ], + "children": [], + "area": 890004.8663999999, + "iscrowd": 0, + "segmentation": [], + "text": "Tools: We have pre-computed)results for all GI's at E-value 1 (higher than,the\ncurrent preset value of 0/01) . Out of this set we extracted -a subset of the,hit list\nat E-value 0.01, and a-subset at E-value 0.001 for comparison.\n\nTest sets: i) all offSwissProt, ii) humanrefGRCh38, a representative human\nproteome, comprised essentially of one representative proteimsequence for each\ncurrently. known human gene.\n\nWemanually inspected a subset of the results having additional hits to determine\nif these hits should be lifted or suppressed. We considered the frequency of the\nnew DA, the taxonomy of that architecture, fragmentation of the new domain hit\nand whether it overlapped with other well supported domains." + }, + { + "id": 86960, + "strid": "f35cf3c2-4889-49a7-8d71-b17eda872eef", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1568.558, + 1220.219, + 1519.19, + 100.769 + ], + "priority": 17, + "parents": [ + 86946 + ], + "children": [], + "area": 1913984.2742020001, + "iscrowd": 0, + "segmentation": [], + "text": "Example Batch CD_Search: a visual representation of additional\ndomains" + }, + { + "id": 86961, + "strid": "648bd4a4-3ad4-441a-87e5-a9318ba41228", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1599.154, + 1330.079, + 1529.984, + 677.3720000000001 + ], + "priority": 18, + "parents": [ + 86946 + ], + "children": [], + "area": 2127001.153166, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86963, + "strid": "44aae29c-da00-422e-b187-ebd4e8d5fce2", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1583.0, + 2075.197, + 1387.917, + 50.15700000000015 + ], + "priority": 19, + "parents": [ + 86981 + ], + "children": [ + 86967, + 86970, + 86973, + 86969, + 86966, + 86965, + 86962, + 86976, + 86971, + 86974, + 86977, + 86975, + 86978, + 86968, + 86964, + 86972 + ], + "area": 3285036.8510000003, + "iscrowd": 0, + "segmentation": [], + "text": "Comparing hit list at E-Value 0.01 wiih hit list at E-value 1" + }, + { + "id": 86962, + "strid": "3a8e499e-6433-43c4-93c8-14f1c34be3c5", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1671.418, + 2141.535, + 1420.7989999999998, + 512.56 + ], + "priority": 20, + "parents": [ + 86963 + ], + "children": [], + "area": 3579400.1466299994, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86964, + "strid": "c84b0f58-2588-44f1-b440-5e2b43ca98f0", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1582.357, + 2684.68, + 1548.1819999999998, + 146.44799999999987 + ], + "priority": 21, + "parents": [ + 86963 + ], + "children": [], + "area": 4248122.19076, + "iscrowd": 0, + "segmentation": [], + "text": "Even at 5% this/translates to a non-trivial # of sequences fm NR receiving\nnew andsreaPannotation (real hits) that are dropped at the default E-value\nthresholaof 0.01" + }, + { + "id": 86965, + "strid": "8603ba31-f43c-478b-852f-ebfcb279c2c8", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1574.308, + 2887.494, + 1484.226, + 114.97899999999981 + ], + "priority": 22, + "parents": [ + 86963 + ], + "children": [], + "area": 4545804.904152, + "iscrowd": 0, + "segmentation": [], + "text": "Example GI with domain to “lift”: HELICc; and one not to “lift”:\nIFT20." + }, + { + "id": 86966, + "strid": "7b22303d-bc7d-424e-a5b5-4adf1008a2ed", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1594.839, + 3028.146, + 752.616, + 558.393 + ], + "priority": 23, + "parents": [ + 86963 + ], + "children": [], + "area": 4829405.338494, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86967, + "strid": "2d320bcc-ce5d-4e5a-8c51-f35a4bc0acf9", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2421.285, + 3044.879, + 719.8180000000002, + 498.297 + ], + "priority": 24, + "parents": [ + 86963 + ], + "children": [], + "area": 7372519.849514999, + "iscrowd": 0, + "segmentation": [], + "text": "SecA is a DEAD-box helicases.\nDEAD-box helicases have both a\nDEXDc and a HELICc domain.\n\n66% of sequences with this DA have\n“new” hits to HELICc that should \\.be\nlifted.\n\nOnly a small subset of possible architectures is\ndiagrammed" + }, + { + "id": 86968, + "strid": "bbd524d3-d0a9-432f-ac2c-140c0829b8a8", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3267.334, + 478.22, + 1428.7709999999997, + 50.03899999999999 + ], + "priority": 25, + "parents": [ + 86963 + ], + "children": [], + "area": 1562504.46548, + "iscrowd": 0, + "segmentation": [], + "text": "Comparing hit list at E-value .01 with hit list at E-value 0.001" + }, + { + "id": 86969, + "strid": "e53a144f-03a7-4a60-be1b-a485bfbd8de6", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 3306.532, + 561.463, + 1409.5479999999998, + 523.4550000000002 + ], + "priority": 26, + "parents": [ + 86963 + ], + "children": [], + "area": 1856495.376316, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86970, + "strid": "f56aaad0-4324-4ff9-a321-c59b074ad562", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3338.918, + 1144.293, + 1366.31, + 97.23199999999997 + ], + "priority": 27, + "parents": [ + 86963 + ], + "children": [], + "area": 3820700.494974, + "iscrowd": 0, + "segmentation": [], + "text": "Evenat 0.5% this translates to a non-trivial # of&sequences in NR\nréceiving annotation at E-value 0.01 that sheuld be suppressed" + }, + { + "id": 86971, + "strid": "701d3400-ef23-4978-8e75-a453eba74508", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3271.736, + 1313.922, + 1037.2740000000003, + 49.94100000000003 + ], + "priority": 28, + "parents": [ + 86963 + ], + "children": [], + "area": 4298805.908592, + "iscrowd": 0, + "segmentation": [], + "text": "Example Gl with domain to “suppress”: Fil1" + }, + { + "id": 86972, + "strid": "1e6f753e-bcb9-439d-bc60-a91ae99cbc42", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3261.822, + 1408.324, + 810.1880000000001, + 603.883 + ], + "priority": 29, + "parents": [ + 86963 + ], + "children": [], + "area": 4593702.206328, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86973, + "strid": "374b0114-3a85-451f-a843-fe4755ccbddb", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4079.045, + 1427.792, + 684.2920000000004, + 632.116 + ], + "priority": 30, + "parents": [ + 86963 + ], + "children": [], + "area": 5824027.81864, + "iscrowd": 0, + "segmentation": [], + "text": "Plant (Poplar) Pectinesterase family\nprotein. The borderline bacterial “FliL”\nhit is fragmentary, overlaps the much\nstronger hit to the plant invertase/pectin\nmethylesterase inhibitor (PME1)\ndomain, and looks out of place ina\nplant protein.\n\nOnly a few sequences in NR have a DA\nhaving FIiL in combination with PME1\nand/or Pectinesterase,domains.\n\nOnly a subset of possible architectures is\ndiagrammed" + }, + { + "id": 86974, + "strid": "0bdf725e-bd66-4c0c-aa8d-8ec2b631c777", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3264.227, + 2098.146, + 1361.9880000000003, + 49.91100000000006 + ], + "priority": 31, + "parents": [ + 86963 + ], + "children": [], + "area": 6848824.8231420005, + "iscrowd": 0, + "segmentation": [], + "text": "A significant portion of the hits to lift are tandem repeats:" + }, + { + "id": 86975, + "strid": "4015278d-e4b9-4c5e-9299-f60442f05222", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3268.596, + 2186.273, + 754.0439999999999, + 482.538 + ], + "priority": 32, + "parents": [ + 86963 + ], + "children": [], + "area": 7146043.182708001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86977, + "strid": "1a1fb22b-00c6-4b6a-aa03-dfe4ea74ccd7", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4050.207, + 2180.895, + 709.6439999999998, + 357.2130000000002 + ], + "priority": 33, + "parents": [ + 86963 + ], + "children": [], + "area": 8833076.195264999, + "iscrowd": 0, + "segmentation": [], + "text": "The Beta-Propeller Of The Btb-\nKelchProtein Krp1 contains 6 Kelch\nrepeats. We detect the 5th repeat at\nE-value 1. The last portion of the\nprotein forms part of the last repeat,\nwith the other part coming from the\nN- terminus." + }, + { + "id": 86978, + "strid": "01f344aa-5865-4f5b-bd83-6d8811b70cbe", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3290.227, + 2676.816, + 903.7709999999997, + 203.71399999999994 + ], + "priority": 34, + "parents": [ + 86963 + ], + "children": [], + "area": 8807332.277231999, + "iscrowd": 0, + "segmentation": [], + "text": "DA cannot be considered in the case of direct\ntandem repeats-as.CDART only reports a\nsingle superfamily footprint, irrespective of the\nrepeat number." + }, + { + "id": 86976, + "strid": "99a5d3e8-d5f2-4894-9c82-bdfaf6ec450d", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 4291.033, + 2583.743, + 330.1850000000004, + 302.2649999999999 + ], + "priority": 35, + "parents": [ + 86963 + ], + "children": [ + 86980 + ], + "area": 11086926.476519, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86980, + "strid": "78dd258e-f1f5-4b09-ab2b-4fd325dbc6cf", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 4259.657, + 2549.029, + 375.83600000000024, + 27.423999999999978 + ], + "priority": 36, + "parents": [ + 86976 + ], + "children": [], + "area": 10857989.223053, + "iscrowd": 0, + "segmentation": [], + "text": "NCBI's structure viewer, Cn3D" + }, + { + "id": 86947, + "strid": "99d43bef-f63c-43bf-a7f0-0c14b4d67cc4", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3273.258, + 2902.91, + 402.326, + 52.501000000000204 + ], + "priority": 37, + "parents": [ + 86981 + ], + "children": [ + 86979 + ], + "area": 9501973.380779998, + "iscrowd": 0, + "segmentation": [], + "text": "@ Conclusions" + }, + { + "id": 86979, + "strid": "06e612c0-2099-44de-b786-3bc359ab8919", + "image_id": 203881, + "image_name": "121092.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3263.855, + 2981.841, + 1506.534, + 576.069 + ], + "priority": 38, + "parents": [ + 86947 + ], + "children": [], + "area": 9732296.657055, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 106667, + "strid": "0fc10e5e-a35f-4325-85d7-d6fff670e753", + "image_id": 204628, + "image_name": "12574.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 5.73, + 12.49, + 16.25, + 107.86 + ], + "priority": -1, + "parents": [], + "children": [ + 106646, + 106643, + 106640, + 106641, + 106650, + 106660, + 106642 + ], + "area": 71.5677, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 106640, + "strid": "2f83c360-f347-4873-aa3f-823a7d678b51", + "image_id": 204628, + "image_name": "12574.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 32.724, + 19.497, + 548.714, + 97.742 + ], + "priority": 1, + "parents": [ + 106667 + ], + "children": [], + "area": 638.019828, + "iscrowd": 0, + "segmentation": [], + "text": "Early physical and functional rehabilitation of\ntrauma patients in the MSF Trauma Center,\nKunduz Afghanistan : luxury or necessity?" + }, + { + "id": 106641, + "strid": "7098564b-fd8d-4bf4-bb81-6fb34e550444", + "image_id": 204628, + "image_name": "12574.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 32.999, + 149.396, + 516.624, + 74.102 + ], + "priority": 2, + "parents": [ + 106667 + ], + "children": [], + "area": 4929.9186039999995, + "iscrowd": 0, + "segmentation": [], + "text": "B Gohy', E Ali?, R Van den Bergh?, E Schillberg?, M Nasim?, M Mahmood Nail\nS Cheréstal‘, P Falipou', E Weerts', P Skelton’, C Van Overloop?, M Trelles*.\n\n \n\n‘Humanity & Inelusion, Brussels, Belgium: “Médecine Sane Frontiéres (MSF), Brussels, Belgium; °MSF, Kabul\nAfghanistan: ‘MSF, Port-au-Prince, Haiti" + }, + { + "id": 106660, + "strid": "4929c702-c53e-48e4-a2e3-c0206873c090", + "image_id": 204628, + "image_name": "12574.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 618.945, + 148.434, + 190.712, + 150.73599999999996 + ], + "priority": 3, + "parents": [ + 106667 + ], + "children": [], + "area": 91872.48213, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 106642, + "strid": "06c71d0f-d6e6-4730-8bf0-30d6692d3d08", + "image_id": 204628, + "image_name": "12574.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 39.594, + 260.119, + 103.023, + 16.798000000000002 + ], + "priority": 4, + "parents": [ + 106667 + ], + "children": [ + 106662, + 106663, + 106644, + 106645 + ], + "area": 10299.151686000001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 106662, + "strid": "8966f0a0-1254-447b-afc9-9fede4b75c5d", + "image_id": 204628, + "image_name": "12574.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 32.772, + 291.301, + 156.129, + 62.93799999999999 + ], + "priority": 5, + "parents": [ + 106642 + ], + "children": [], + "area": 9546.516372, + "iscrowd": 0, + "segmentation": [], + "text": "The increased quailty of care has\nlod toa higher survival rate of\nseverely injured patients, leaving\nmace individuals with long term\neabilities." + }, + { + "id": 106663, + "strid": "6d4d11ba-034b-4401-843c-8f472bfd2526", + "image_id": 204628, + "image_name": "12574.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 32.947, + 369.105, + 162.909, + 76.79700000000003 + ], + "priority": 6, + "parents": [ + 106642 + ], + "children": [], + "area": 12160.902435000002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 106644, + "strid": "71915188-9bf5-4c3d-b164-53de9f779da4", + "image_id": 204628, + "image_name": "12574.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 32.896, + 460.089, + 162.962, + 85.37799999999999 + ], + "priority": 7, + "parents": [ + 106642 + ], + "children": [], + "area": 15135.087744, + "iscrowd": 0, + "segmentation": [], + "text": "MSF Integrated early rehabilitation\nservices init Kundu Trauma\nGenter (KTC) in collaboration with\nHandicap International (H).\nBesides, an adapted functional\nscore was developed in that\nee" + }, + { + "id": 106645, + "strid": "f758ff91-1e2c-426e-a745-acb9b49370b5", + "image_id": 204628, + "image_name": "12574.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 33.129, + 552.368, + 175.977, + 93.78599999999994 + ], + "priority": 8, + "parents": [ + 106642 + ], + "children": [], + "area": 18299.399472, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 106643, + "strid": "311e10bc-887a-4628-a8c6-0cfed3a0b474", + "image_id": 204628, + "image_name": "12574.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 234.541, + 264.039, + 74.06700000000001, + 17.223000000000013 + ], + "priority": 9, + "parents": [ + 106667 + ], + "children": [ + 106658, + 106664, + 106656, + 106659 + ], + "area": 61927.971098999995, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 106656, + "strid": "4f3c7ca1-44a4-4cfa-802a-822cee94a97d", + "image_id": 204628, + "image_name": "12574.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 233.654, + 303.564, + 532.833, + 101.024 + ], + "priority": 10, + "parents": [ + 106643 + ], + "children": [], + "area": 70928.94285600001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 106658, + "strid": "940aed30-5b4a-4c75-9bd0-6d4c3f7b19fd", + "image_id": 204628, + "image_name": "12574.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 233.932, + 443.852, + 302.693, + 207.83399999999995 + ], + "priority": 11, + "parents": [ + 106643 + ], + "children": [ + 106657 + ], + "area": 103831.186064, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 106657, + "strid": "be859170-5472-4030-84a8-380eae161cf0", + "image_id": 204628, + "image_name": "12574.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 235.141, + 418.952, + 363.154, + 20.858000000000004 + ], + "priority": 12, + "parents": [ + 106658 + ], + "children": [], + "area": 98512.79223199999, + "iscrowd": 0, + "segmentation": [], + "text": "Box 1. Adapted Funchonal independence Measure used with acute trauma patients,\nbn Gra bdddiinn eaves Frontcen Kinther Traces Canter" + }, + { + "id": 106664, + "strid": "b951666c-c4b6-4655-a8a8-8ed68fed7cc3", + "image_id": 204628, + "image_name": "12574.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 613.266, + 468.087, + 129.91200000000003, + 25.773000000000025 + ], + "priority": 13, + "parents": [ + 106643 + ], + "children": [], + "area": 287061.842142, + "iscrowd": 0, + "segmentation": [], + "text": "Functional score adapted to\ncontext through:" + }, + { + "id": 106659, + "strid": "695a7e12-09de-452d-9ac2-4f6dc8d0c4b0", + "image_id": 204628, + "image_name": "12574.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 612.893, + 505.95, + 130.69499999999994, + 99.71599999999995 + ], + "priority": 14, + "parents": [ + 106643 + ], + "children": [], + "area": 310093.21335000003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 106646, + "strid": "e5008f7b-0876-4dc3-aad6-23d12f5332a0", + "image_id": 204628, + "image_name": "12574.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 39.768, + 687.799, + 64.217, + 15.672000000000025 + ], + "priority": 15, + "parents": [ + 106667 + ], + "children": [ + 106654, + 106665, + 106647, + 106652, + 106651, + 106661, + 106653 + ], + "area": 27352.390632, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 106653, + "strid": "c5c423d5-8ce3-4bfb-a21a-6bff13e490f1", + "image_id": 204628, + "image_name": "12574.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 194.477, + 683.863, + 172.74300000000002, + 24.29600000000005 + ], + "priority": 16, + "parents": [ + 106646 + ], + "children": [], + "area": 132995.62465100002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 106651, + "strid": "710cfab9-18f5-4e26-ace2-2e054b64ff3c", + "image_id": 204628, + "image_name": "12574.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 35.536, + 718.999, + 382.029, + 112.13 + ], + "priority": 17, + "parents": [ + 106646 + ], + "children": [], + "area": 25550.348464000002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 106661, + "strid": "15dea044-c0e1-4b70-a86f-89512184870c", + "image_id": 204628, + "image_name": "12574.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 41.336, + 875.422, + 330.657, + 226.529 + ], + "priority": 18, + "parents": [ + 106646 + ], + "children": [ + 106666, + 106655 + ], + "area": 36186.443792, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 106655, + "strid": "ca539dad-248c-4b5e-abb5-4761b6376eaf", + "image_id": 204628, + "image_name": "12574.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 37.765, + 843.862, + 334.705, + 23.317999999999984 + ], + "priority": 19, + "parents": [ + 106661 + ], + "children": [], + "area": 31868.44843, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. Adapted Functional independence Measure used with acute trauma\npatients, in the Médecins sans Fronfigres Kunduz Trauma Center" + }, + { + "id": 106666, + "strid": "55dd2481-4df9-4c51-85ec-ca6078b56c15", + "image_id": 204628, + "image_name": "12574.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 26.229, + 1105.332, + 351.954, + 33.327 + ], + "priority": 20, + "parents": [ + 106661 + ], + "children": [], + "area": 28991.753028000003, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 106652, + "strid": "04298b17-db8a-4fe8-bbab-dc2005efa3de", + "image_id": 204628, + "image_name": "12574.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 442.158, + 706.506, + 140.35199999999998, + 135.827 + ], + "priority": 21, + "parents": [ + 106646 + ], + "children": [], + "area": 312387.279948, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 106647, + "strid": "88a98360-c733-472f-a06a-d9baaf5da59f", + "image_id": 204628, + "image_name": 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[], + "area": 460002.69361500005, + "iscrowd": 0, + "segmentation": [], + "text": "The __kiegution =— sso\nphysiotherapists within any\ntrauma medical team should be\na necessity\n\nThe use of the adapted\nfunctional score was shown to\nbe feasible for complex trauma\npatients with different types of\ninjury in a humanitarian\nsetting." + }, + { + "id": 106648, + "strid": "943cc79d-6ce7-4d75-9b02-367e7af9f975", + "image_id": 204628, + "image_name": "12574.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 633.003, + 896.97, + 178.611, + 150.5719999999999 + ], + "priority": 27, + "parents": [ + 106650 + ], + "children": [], + "area": 567784.70091, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements\nThsresera is descle ou coeages,\nErdal Oxo, aswel sthose wo have bee\nThe shor woud ae han MSF\npylterapy ean te eaten an\ncust wrk trougout ne pes wen he\nShuabn was area catenin\nTnsresearch was sippres un an\noperational esearch course, coved he\nCone or Operations Resear eran)\nUnion gaint Tera Lung Dae,\narte Opuaonal sec Ut Mears" + }, + { + "id": 194455, + "strid": "05e8edd4-060a-4b00-aa97-3d20df78c41b", + "image_id": 208108, + "image_name": "9389.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 119.61, + 418.47, + 201.14, + 321.8299999999999 + ], + "priority": -1, + "parents": [], + "children": [ + 194440, + 194442, + 194445, + 194443, + 194441, + 194444 + ], + "area": 50053.1967, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 194440, + "strid": "4ac9125a-dae9-4508-b94f-13a3367fe7b8", + "image_id": 208108, + "image_name": "9389.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 394.234, + 385.912, + 2573.096, + 416.57800000000003 + ], + "priority": 1, + "parents": [ + 194455 + ], + "children": [], + "area": 152139.631408, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction of a General Practitioner Cooperative\ndid not lead to a decrease in workload at the ED in\nThe Hague, Netherlands" + }, + { + "id": 194441, + "strid": "df02b924-dfe0-4dbb-a003-7eebe907f6f6", + "image_id": 208108, + "image_name": "9389.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 94.239, + 892.411, + 2226.62, + 115.13 + ], + "priority": 2, + "parents": [ + 194455 + ], + "children": [], + "area": 84099.920229, + "iscrowd": 0, + "segmentation": [], + "text": "Michiel J. VAN VEELEN}, Crispijn L. VAN DEN BRAND}, T.M.A.J. (Resi) REJNEN?, M. Christien VAN DER LINDEN?\n1 Emergency Department, Medical Centre Haaglanden, The Hague, The Netherlands" + }, + { + "id": 194442, + "strid": "c96adb36-5735-4233-8541-f3b89d01f724", + "image_id": 208108, + "image_name": "9389.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 112.012, + 1160.593, + 235.209, + 56.146999999999935 + ], + "priority": 3, + "parents": [ + 194455 + ], + "children": [ + 194446 + ], + "area": 130000.343116, + "iscrowd": 0, + "segmentation": [], + "text": "Objectives" + }, + { + "id": 194446, + "strid": "88e43532-ef2b-4a90-b556-01f603fadf15", + "image_id": 208108, + "image_name": "9389.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 110.37, + 1225.897, + 2007.076, + 309.7249999999999 + ], + "priority": 4, + "parents": [ + 194442 + ], + "children": [], + "area": 135302.25188999998, + "iscrowd": 0, + "segmentation": [], + "text": "In 2013 a General Practitioner Cooperative (GPC) was introduced at the Emergency\nDepartment (ED) of our hospital with the aim of relieving workload. To determine the effect\nwe measured the amount of self-referrals, redirection of self-referrals to the GPC and back to\nthe ED as well as characteristics of the remaining ED population regarding level of acuity and\n\nlength of stay (LOS)." + }, + { + "id": 194443, + "strid": "9aec291b-1516-4753-96c4-0c7e11d8eb2b", + "image_id": 208108, + "image_name": "9389.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 111.159, + 1604.487, + 205.60400000000004, + 51.30400000000009 + ], + "priority": 5, + "parents": [ + 194455 + ], + "children": [ + 194447 + ], + "area": 178353.17043300002, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 194447, + "strid": "9b756f02-a609-4e71-b698-72bc2d027fab", + "image_id": 208108, + "image_name": "9389.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 110.652, + 1667.138, + 1210.221, + 55.42100000000005 + ], + "priority": 6, + "parents": [ + 194443 + ], + "children": [], + "area": 184472.153976, + "iscrowd": 0, + "segmentation": [], + "text": "A before- and after interventional study was performed." + }, + { + "id": 194444, + "strid": "329959ed-3d90-4f8b-a040-c924e06e2f0d", + "image_id": 208108, + "image_name": "9389.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 112.697, + 1795.137, + 163.531, + 47.49199999999996 + ], + "priority": 7, + "parents": [ + 194455 + ], + "children": [ + 194454, + 194452, + 194451, + 194453, + 194448, + 194450 + ], + "area": 202306.554489, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 194448, + "strid": "a6c3c184-17c7-46a9-9da6-8ac0adbaa2d3", + "image_id": 208108, + "image_name": "9389.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 109.774, + 1857.881, + 1982.4480000000003, + 246.3660000000002 + ], + "priority": 8, + "parents": [ + 194444 + ], + "children": [], + "area": 203947.02889400002, + "iscrowd": 0, + "segmentation": [], + "text": "Almost half of our ED patients were self-referrals (45.5%), 54.5% of them were redirected to\nthe GPC. 8.5% of them were referred back to the ED. There was a significant increase in\nhighly urgent (Manchester Triage System level 2) patients (1,106 vs. 1,331 patients) and LOS\n(89min vs. 125min, P<0.005) of the ED patients." + }, + { + "id": 194450, + "strid": "6e8776bf-ae0d-41b9-890e-d0b43fee96be", + "image_id": 208108, + "image_name": "9389.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 72.689, + 2314.189, + 1001.041, + 890.4859999999999 + ], + "priority": 9, + "parents": [ + 194444 + ], + "children": [], + "area": 168216.08422099997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 194451, + "strid": "2c7a8030-620b-4709-b829-3edc289bf153", + "image_id": 208108, + "image_name": "9389.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1089.194, + 2271.991, + 1045.964, + 930.009 + ], + "priority": 10, + "parents": [ + 194444 + ], + "children": [], + "area": 2474638.965254, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 194452, + "strid": "c1e24933-f556-4b65-aef1-571d3da85811", + "image_id": 208108, + "image_name": "9389.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2150.843, + 2263.004, + 1081.1509999999998, + 1046.0079999999998 + ], + "priority": 11, + "parents": [ + 194444 + ], + "children": [], + "area": 4867366.312371999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 194453, + "strid": "3d0f948a-9bc7-4b3c-b690-7f0206f53d6e", + "image_id": 208108, + "image_name": "9389.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 101.225, + 3512.162, + 1582.388, + 689.7760000000003 + ], + "priority": 12, + "parents": [ + 194444 + ], + "children": [], + "area": 355518.59844999993, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 194454, + "strid": "e00f80ba-0410-454a-a50f-e5d3c9e56cbc", + "image_id": 208108, + "image_name": "9389.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1716.64, + 3490.025, + 1464.767, + 950.4360000000001 + ], + "priority": 13, + "parents": [ + 194444 + ], + "children": [], + "area": 5991116.516000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 194445, + "strid": "e4011e86-649b-439e-8d6f-67579b1cd69b", + "image_id": 208108, + "image_name": "9389.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2307.348, + 1228.614, + 420.8290000000002, + 71.577 + ], + "priority": 14, + "parents": [ + 194455 + ], + "children": [ + 194449 + ], + "area": 2834840.055672, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 194449, + "strid": "20c4faef-af4b-4d34-86aa-b54f5d895e78", + "image_id": 208108, + "image_name": "9389.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2306.671, + 1416.01, + 859.0239999999999, + 474.597 + ], + "priority": 15, + "parents": [ + 194445 + ], + "children": [], + "area": 3266269.20271, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction of a GPC led\nto efficient redirection of\nself-referrals but did not\nlead to a decrease in\nworkload at the ED." + }, + { + "id": 60933, + "strid": "46565ebe-9aeb-49e7-9e1f-fc721ecffcd0", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 323.91, + 85.37, + 271.6499999999999, + 263.9 + ], + "priority": -1, + "parents": [], + "children": [ + 60927, + 60898, + 60895, + 60926, + 60896, + 60928, + 60899, + 60897 + ], + "area": 27652.196700000004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 60895, + "strid": "4175daf7-7093-49d1-b485-da31d0caf458", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 679.048, + 31.934, + 1898.343, + 219.452 + ], + "priority": 1, + "parents": [ + 60933 + ], + "children": [], + "area": 21684.718832000002, + "iscrowd": 0, + "segmentation": [], + "text": "Prevalence of anxiety and depression among\nalcohol dependent patients" + }, + { + "id": 60896, + "strid": "a0916264-6063-4254-a7f1-105b5840e44c", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 794.262, + 262.079, + 1656.876, + 238.671 + ], + "priority": 2, + "parents": [ + 60933 + ], + "children": [], + "area": 208159.390698, + "iscrowd": 0, + "segmentation": [], + "text": "Sofia S. Fedorova\nI.M. Sechenov First Moscow State Medical University,\nDepartment of Psychiatry and Narcology, Moscow, Russia" + }, + { + "id": 60897, + "strid": "bddb2a78-eb73-4dc9-b895-6824f57ee711", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 221.374, + 666.621, + 367.317, + 54.78800000000001 + ], + "priority": 3, + "parents": [ + 60933 + ], + "children": [ + 60901, + 60900 + ], + "area": 147572.55725399998, + "iscrowd": 0, + "segmentation": [], + "text": "Iitroduction" + }, + { + "id": 60900, + "strid": "5d67846b-ea54-42f0-a502-83db1e7d2db2", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 221.656, + 766.283, + 831.337, + 692.0469999999999 + ], + "priority": 4, + "parents": [ + 60897 + ], + "children": [], + "area": 169851.224648, + "iscrowd": 0, + "segmentation": [], + "text": "Anxiety and mood disorders are highly‘\ncomorbid with alcohol dependence ai\nare usually more severe when they cur\nthan when they present alone. oO\n<.\n\nAlcohol use in attempt Ne) e anxiety\n\n(self-medication hypot as often been\n\nused as an explanati the high\n\ncomorbidity rates {tw en anxiety, depression\ns\n\nand alcohol use disorders.\n\n°\nThe aim € study is to examine the\nassociatiombetween mood and anxiety\ndisordér§~and alcohol dependence." + }, + { + "id": 60901, + "strid": "046a2535-f523-4c25-a273-64f1abe80e25", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 450.642, + 1501.829, + 366.612, + 334.5339999999999 + ], + "priority": 5, + "parents": [ + 60897 + ], + "children": [], + "area": 676787.224218, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 60899, + "strid": "35852467-a7c8-41af-897a-411fb241e970", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 223.637, + 2040.391, + 660.212, + 56.751000000000204 + ], + "priority": 6, + "parents": [ + 60933 + ], + "children": [ + 60922, + 60929, + 60919 + ], + "area": 456306.922067, + "iscrowd": 0, + "segmentation": [], + "text": "Materials and methods" + }, + { + "id": 60922, + "strid": "09e10c55-b64c-4380-9aa9-3eb5042e0a1f", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 181.357, + 2233.588, + 928.645, + 860.3710000000001 + ], + "priority": 7, + "parents": [ + 60899 + ], + "children": [ + 60913 + ], + "area": 405076.818916, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 60913, + "strid": "eaa88a5b-2937-48f6-8ade-a1d98ebbb094", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 222.535, + 2140.821, + 745.676, + 46.85100000000011 + ], + "priority": 8, + "parents": [ + 60922 + ], + "children": [], + "area": 476407.60123499995, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1. Chafacter istics of Participants" + }, + { + "id": 60919, + "strid": "c0d5dc85-35c2-4658-91ae-1353f20d9d0f", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 223.873, + 3145.604, + 685.7639999999999, + 366.80499999999984 + ], + "priority": 9, + "parents": [ + 60899 + ], + "children": [], + "area": 704215.8042919999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 60929, + "strid": "14885cd7-db80-4b27-a674-734129d35764", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 223.639, + 3546.235, + 686.325, + 143.66899999999987 + ], + "priority": 10, + "parents": [ + 60899 + ], + "children": [], + "area": 793076.4491650001, + "iscrowd": 0, + "segmentation": [], + "text": "Semi-structured interview was\\used to\ninvestigate social factorsaay ourse\ncharacteristics. DR." + }, + { + "id": 60898, + "strid": "7698ff8b-0f65-4078-8f31-aee9d64ea08b", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1294.5, + 666.957, + 194.75299999999993, + 50.06200000000001 + ], + "priority": 11, + "parents": [ + 60933 + ], + "children": [ + 60916, + 60902, + 60905, + 60917, + 60904, + 60903, + 60907, + 60918, + 60924, + 60906, + 60923 + ], + "area": 863375.8365, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 60916, + "strid": "61697c82-c4cb-430c-be3d-636fbad7e1be", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1294.261, + 752.542, + 1687.4590000000003, + 100.928 + ], + "priority": 12, + "parents": [ + 60898 + ], + "children": [], + "area": 973985.761462, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 60902, + "strid": "49455b03-1c3c-4229-9b9b-32e0954a35df", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1400.774, + 1067.919, + 483.9369999999999, + 276.18499999999995 + ], + "priority": 13, + "parents": [ + 60898 + ], + "children": [ + 60908 + ], + "area": 1495913.169306, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 60908, + "strid": "39e097d8-8652-403e-b980-d69acb043b4c", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1347.297, + 909.052, + 367.1199999999999, + 97.21100000000001 + ], + "priority": 14, + "parents": [ + 60902 + ], + "children": [], + "area": 1224763.032444, + "iscrowd": 0, + "segmentation": [], + "text": "Fig 1. Prevalenc\ncomorbid anxi&" + }, + { + "id": 60903, + "strid": "baa5497e-ee3e-4f63-a158-c038bd20d071", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1954.741, + 1068.142, + 455.6289999999999, + 274.0640000000001 + ], + "priority": 15, + "parents": [ + 60898 + ], + "children": [ + 60909 + ], + "area": 2087940.9612220002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 60909, + "strid": "19659278-6f86-4b55-91f1-2abbba4f8b66", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1944.735, + 908.82, + 379.9889999999998, + 101.17499999999995 + ], + "priority": 16, + "parents": [ + 60903 + ], + "children": [], + "area": 1767414.0627, + "iscrowd": 0, + "segmentation": [], + "text": "Fig 2. Prevalence of\ncomorbid depression" + }, + { + "id": 60904, + "strid": "b80aa5ba-badd-41d5-b0fd-4386a48cb630", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2509.154, + 1024.153, + 628.3809999999999, + 359.3120000000001 + ], + "priority": 17, + "parents": [ + 60898 + ], + "children": [ + 60910 + ], + "area": 2569757.596562, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 60910, + "strid": "9c8c9891-235a-4151-aae5-3bae2ad8ce0e", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2533.626, + 903.981, + 483.8760000000002, + 98.77999999999997 + ], + "priority": 18, + "parents": [ + 60904 + ], + "children": [], + "area": 2290349.765106, + "iscrowd": 0, + "segmentation": [], + "text": "ig 3. Correlation between\nanxiety and depression" + }, + { + "id": 60917, + "strid": "5d6d4eba-dfab-47ab-a7a8-08c34f1c622a", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1296.14, + 1371.093, + 1210.997, + 47.55300000000011 + ], + "priority": 19, + "parents": [ + 60898 + ], + "children": [], + "area": 1777128.4810200003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 60905, + "strid": "d7f81c0e-9c95-4085-9d6b-b053b1ecb226", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1351.459, + 1576.411, + 673.433, + 350.192 + ], + "priority": 20, + "parents": [ + 60898 + ], + "children": [ + 60911 + ], + "area": 2130454.833649, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 60911, + "strid": "ff9f60d3-40a6-4e41-8d4a-393ec3a8675d", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1344.281, + 1457.135, + 442.55200000000013, + 97.44100000000003 + ], + "priority": 21, + "parents": [ + 60905 + ], + "children": [], + "area": 1958798.894935, + "iscrowd": 0, + "segmentation": [], + "text": "Fig 4. Comorbid anxiety\ndisorders and gender" + }, + { + "id": 60906, + "strid": "2aba77f0-042a-4c8e-9bae-78b2bb82d776", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2280.253, + 1557.495, + 714.7329999999997, + 380.02099999999996 + ], + "priority": 22, + "parents": [ + 60898 + ], + "children": [ + 60912 + ], + "area": 3551482.646235, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 60912, + "strid": "ee1e948d-4e9f-4402-81f3-b2028ae47f6e", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2284.232, + 1456.904, + 578.4520000000002, + 97.41499999999996 + ], + "priority": 23, + "parents": [ + 60906 + ], + "children": [], + "area": 3327906.737728, + "iscrowd": 0, + "segmentation": [], + "text": "Fig 5. Comorbid depression .\ngender q" + }, + { + "id": 60918, + "strid": "baa57cff-adbf-4c3c-b96d-985d8925fa24", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1292.838, + 1993.037, + 843.0809999999999, + 528.858 + ], + "priority": 24, + "parents": [ + 60898 + ], + "children": [], + "area": 2576673.969006, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 60907, + "strid": "7b0b0a39-97aa-48c9-b376-e34d762873ed", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2222.743, + 2099.074, + 911.8299999999999, + 405.04100000000017 + ], + "priority": 25, + "parents": [ + 60898 + ], + "children": [ + 60914 + ], + "area": 4665702.039982, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 60914, + "strid": "94f30b82-9c73-4b57-a68d-83963e5ba748", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2162.206, + 1993.034, + 706.875, + 98.63900000000012 + ], + "priority": 26, + "parents": [ + 60907 + ], + "children": [], + "area": 4309350.073004001, + "iscrowd": 0, + "segmentation": [], + "text": "Fig 6. Tratimatic life events that lead to\nheay¥drinking" + }, + { + "id": 60923, + "strid": "ea31dd72-dc31-4ce4-a7f2-42e3e64c35ae", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1330.239, + 2659.442, + 805.239, + 378.94399999999996 + ], + "priority": 27, + "parents": [ + 60898 + ], + "children": [ + 60925 + ], + "area": 3537693.466638, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 60925, + "strid": "56236b7e-131f-41d3-8b9e-f2e680079586", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1334.261, + 2543.992, + 666.923, + 96.72200000000021 + ], + "priority": 28, + "parents": [ + 60923 + ], + "children": [], + "area": 3394349.3099120003, + "iscrowd": 0, + "segmentation": [], + "text": "Fig 7. Association of self-medication\nwith comorbid anxi" + }, + { + "id": 60924, + "strid": "6806b630-7edf-4344-90a9-687ba62427c9", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2279.434, + 2654.798, + 841.0119999999997, + 370.5749999999998 + ], + "priority": 29, + "parents": [ + 60898 + ], + "children": [ + 60915 + ], + "area": 6051436.824332, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 60915, + "strid": "1eb4da0b-1a8b-4431-ad12-de574f28acbc", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2273.352, + 2542.499, + 657.6700000000001, + 46.88999999999987 + ], + "priority": 30, + "parents": [ + 60924 + ], + "children": [], + "area": 5779995.186647999, + "iscrowd": 0, + "segmentation": [], + "text": "Fig 8. Mean age andJevel of anxiety" + }, + { + "id": 60926, + "strid": "563d4a98-d040-4c8e-bd47-cffb7000b40b", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1347.547, + 3217.197, + 348.23900000000003, + 56.77799999999979 + ], + "priority": 31, + "parents": [ + 60933 + ], + "children": [ + 60920, + 60921 + ], + "area": 4335324.165759, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 60920, + "strid": "0f0d2e12-c2f2-465b-9400-d85d468a29e9", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1345.139, + 3343.172, + 846.8430000000001, + 377.83500000000004 + ], + "priority": 32, + "parents": [ + 60926 + ], + "children": [], + "area": 4497031.0409079995, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 60921, + "strid": "55b3dc80-9bce-4cbe-93a5-14139c468e26", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2242.706, + 3225.395, + 836.935, + 532.4650000000001 + ], + "priority": 33, + "parents": [ + 60926 + ], + "children": [], + "area": 7233612.71887, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 60927, + "strid": "7732ab5f-0321-410f-ab0c-176d8ece30d8", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1915.157, + 3972.72, + 556.3990000000001, + 68.34799999999996 + ], + "priority": 34, + "parents": [ + 60933 + ], + "children": [ + 60931, + 60932 + ], + "area": 7608382.517039999, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements" + }, + { + "id": 60931, + "strid": "7f35e97d-e8cd-4d28-aa09-9195ce5e84f8", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1800.26, + 4105.506, + 947.8239999999998, + 313.15200000000004 + ], + "priority": 35, + "parents": [ + 60927 + ], + "children": [], + "area": 7390978.23156, + "iscrowd": 0, + "segmentation": [], + "text": "A spé¢jal thank to my advisor Yuri Sivolap. kor.\nfordhis project were provided by S.S. Korsakov\nPsychiatry hospital and Moscow Research an\nPractical Centre for Narcology of the Depagtmént of\nPublic Health (NKB Ne17). I thank An\n\nPoltorobat’ko for his nice painting. |" + }, + { + "id": 60932, + "strid": "f6e43a5d-4df9-483f-be64-b77a489bcaac", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2804.667, + 3897.046, + 391.57699999999977, + 581.4329999999995 + ], + "priority": 36, + "parents": [ + 60927 + ], + "children": [], + "area": 10929916.313682, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 60928, + "strid": "e7b531ba-216b-4cf6-996e-e8c8927f4f83", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 221.345, + 3974.446, + 316.53, + 53.24800000000005 + ], + "priority": 37, + "parents": [ + 60933 + ], + "children": [ + 60930 + ], + "area": 879723.7498699999, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 60930, + "strid": "6f31d9d9-0816-433f-adeb-4ec00800c832", + "image_id": 202905, + "image_name": "119428.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 222.724, + 4069.887, + 1228.301, + 462.5310000000004 + ], + "priority": 38, + "parents": [ + 60928 + ], + "children": [], + "area": 906461.512188, + "iscrowd": 0, + "segmentation": [], + "text": "Mefiary KR, Kushner MG, Maurer E, Thuras P. The nce and clinical\nimplications of self-medication among individuals wy nxiety disorders.\nJ.Anxiety Disord. 2011;25(3):335-9.\n\n&\n\nGrant BF, Stinson FS, Dawson DA, et al. Prévalence and co-occurrence of\nsubstance use disorders and independ food and anxiety disorders: results\nfrom the National Epidemiologic Sure on Alcohol and Related Conditions.\nArch Gen Psychiatry. 2004;61 8079.\n\nDeMartini KS, Carey KB. The Oot anxiety sensitivity and drinking motives\nin predicting alcohol use: a criti€al review. Clin Psychol Rev. 2011;31:169-77." + }, + { + "id": 93488, + "strid": "a08fc884-fad6-45bc-8c94-b8635ace33fb", + "image_id": 204123, + "image_name": "121481.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 140.39, + 92.34, + 188.21000000000004, + 188.22 + ], + "priority": -1, + "parents": [], + "children": [ + 93461, + 93468, + 93470, + 93448, + 93445, + 93463, + 93450, + 93466, + 93452, + 93462, + 93446 + ], + "area": 12963.612599999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 93445, + "strid": "1a88763d-0a38-4a87-a25a-78d686040fa7", + "image_id": 204123, + "image_name": "121481.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 821.778, + 97.046, + 1666.0829999999999, + 85.06400000000001 + ], + "priority": 1, + "parents": [ + 93488 + ], + "children": [], + "area": 79750.26778800001, + "iscrowd": 0, + "segmentation": [], + "text": "How stories communicate daily living with ALS" + }, + { + "id": 93446, + "strid": 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"segmentation": [], + "text": "To explore how stories can communicate experiences of daily\nliving with ALS and compensate the progressive loss of abili-\nty to speak." + }, + { + "id": 93454, + "strid": "948bbbb6-f3e4-478d-90aa-8ae7ed708c2d", + "image_id": 204123, + "image_name": "121481.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1242.225, + 1080.214, + 823.9650000000001, + 549.9200000000001 + ], + "priority": 11, + "parents": [ + 93450 + ], + "children": [ + 93476 + ], + "area": 1341868.8361499999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 93476, + "strid": "7340e0dc-aa82-4ab1-b411-527d90daa18a", + "image_id": 204123, + "image_name": "121481.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1875.916, + 1635.548, + 195.615, + 27.169000000000096 + ], + "priority": 12, + "parents": [ + 93454 + ], + "children": [], + "area": 3068150.661968, + "iscrowd": 0, + "segmentation": [], + "text": "Photo: S¢ren Holm" + }, + { + "id": 93475, 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Topics of stories\nwere categorized and selected themes analysed and interpreted." + }, + { + "id": 93455, + "strid": "7f791516-6726-45ba-9890-6844c683efb0", + "image_id": 204123, + "image_name": "121481.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2458.191, + 1076.159, + 557.7179999999998, + 553.662 + ], + "priority": 17, + "parents": [ + 93448 + ], + "children": [ + 93478 + ], + "area": 2645404.368369, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 93478, + "strid": "b20c8077-303d-4b29-94d2-c5640187c199", + "image_id": 204123, + "image_name": "121481.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2817.89, + 1638.132, + 200.38099999999986, + 22.00299999999993 + ], + "priority": 18, + "parents": [ + 93455 + ], + "children": [], + "area": 4616075.78148, + "iscrowd": 0, + "segmentation": [], + "text": "Photo: S¢ren Holm" + }, + { + "id": 93477, + "strid": "2a9143d9-5a41-40c5-b9d5-715f50b7233b", + "image_id": 204123, + "image_name": "121481.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2403.769, + 1730.857, + 671.0790000000002, + 58.934999999999945 + ], + "priority": 19, + "parents": [ + 93448 + ], + "children": [], + "area": 4160580.4000329995, + "iscrowd": 0, + "segmentation": [], + "text": "Ole Lagtved Nielsen’s story" + }, + { + "id": 93479, + "strid": "ed1aef39-20cb-4728-b4b5-ee318609e7ff", + "image_id": 204123, + "image_name": "121481.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2322.046, + 1847.942, + 699.3679999999999, + 242.029 + ], + "priority": 20, + "parents": [ + 93448 + ], + "children": [], + "area": 4291006.329332, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 93462, + "strid": "138294da-5260-4ec1-9106-f7cac925bb82", + "image_id": 204123, + "image_name": "121481.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 126.207, + 2332.531, + 239.664, + 52.49800000000005 + ], + "priority": 21, + "parents": [ + 93488 + ], + "children": [ + 93480, + 93481, + 93459, + 93458 + ], + "area": 294381.739917, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 93459, + "strid": "f13acb83-e3f6-48f3-a915-6543fb78a0d9", + "image_id": 204123, + "image_name": "121481.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 118.617, + 2406.843, + 896.493, + 306.1970000000001 + ], + "priority": 22, + "parents": [ + 93462 + ], + "children": [], + "area": 285492.496131, + "iscrowd": 0, + "segmentation": [], + "text": "The stories communicated daily living with ALS as a con-\ntinuous process of creating a new normality of everyday life.\nThe stories also revealed conflicting views between patient\nand professionals about information about disease and prog-\nnosis. The approach used provided an understanding that in-\nformed individual healthcare professionals’ engagement with\nthe patient." + }, + { + "id": 93458, + "strid": "371d2b53-f557-4643-972d-599cd888864b", + "image_id": 204123, + "image_name": "121481.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 165.94, + 2936.181, + 822.6319999999998, + 546.0700000000002 + ], + "priority": 23, + "parents": [ + 93462 + ], + "children": [ + 93482 + ], + "area": 487229.87514, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 93482, + "strid": "ba7b9b6f-00ed-482c-9ad4-22bf0d7e649d", + "image_id": 204123, + "image_name": "121481.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 792.75, + 3485.378, + 196.029, + 29.35699999999997 + ], + "priority": 24, + "parents": [ + 93458 + ], + "children": [], + "area": 2763033.4095, + "iscrowd": 0, + "segmentation": [], + "text": "Photo: S¢ren Holm" + }, + { + "id": 93481, + "strid": "6853c86b-5c49-4b4f-a0cc-f4effcef3130", + "image_id": 204123, + "image_name": "121481.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 229.285, + 3580.078, + 699.833, + 58.71399999999994 + ], + "priority": 25, + "parents": [ + 93462 + ], + "children": [], + "area": 820858.18423, + "iscrowd": 0, + "segmentation": [], + "text": "Egon Leth Mogensen’s story" + }, + { + "id": 93480, + "strid": "cdb4a972-6e31-43a9-a003-a37dfca7d2fe", + "image_id": 204123, + "image_name": "121481.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 162.048, + 3702.241, + 786.01, + 237.69700000000012 + ], + "priority": 26, + "parents": [ + 93462 + ], + "children": [], + "area": 599940.749568, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 93461, + "strid": "56c1b42e-62c4-4f5d-ba96-37dfa0ba17f5", + "image_id": 204123, + "image_name": "121481.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1205.838, + 2331.39, + 338.95399999999995, + 58.20400000000018 + ], + "priority": 27, + "parents": [ + 93488 + ], + "children": [ + 93457, + 93484, + 93483, + 93460 + ], + "area": 2811278.65482, + "iscrowd": 0, + "segmentation": [], + "text": "DISCUSSION" + }, + { + "id": 93460, + "strid": "4e0cf010-2865-40e5-88a4-74be5aaa0b11", + "image_id": 204123, + "image_name": "121481.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1201.418, + 2406.843, + 885.3799999999999, + 262.77599999999984 + ], + "priority": 28, + "parents": [ + 93461 + ], + "children": [], + "area": 2891624.5033739996, + "iscrowd": 0, + "segmentation": [], + "text": "The narrative journalistic story enhances communication\nabout daily living with ALS by offering a mode of sharing\nexperiences that compensate the progressive loss of com-\nmunicative abilities. The story can sustain meaning in living\nwith ALS and support patients to appreciate a day-to-day life\nwhich is not just a waiting for death." + }, + { + "id": 93457, + "strid": "b4f21ae0-00fa-4290-ae69-1e082ceccd4e", + "image_id": 204123, + "image_name": "121481.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1242.118, + 2928.756, + 826.0990000000002, + 555.0 + ], + "priority": 29, + "parents": [ + 93461 + ], + "children": [], + "area": 3637860.5452079996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 93483, + "strid": "68bb7617-3338-46ac-b925-5d577f1f7f13", + "image_id": 204123, + "image_name": "121481.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1388.412, + 3581.025, + 534.108, + 56.820000000000164 + ], + "priority": 30, + "parents": [ + 93461 + ], + "children": [], + "area": 4971938.0823, + "iscrowd": 0, + "segmentation": [], + "text": "Conny Hansen’s story" + }, + { + "id": 93484, + "strid": "b51d508b-7ae6-4c76-a6e1-c938b30ee521", + "image_id": 204123, + "image_name": "121481.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1238.787, + 3695.612, + 766.123, + 239.5909999999999 + ], + "priority": 31, + "parents": [ + 93461 + ], + "children": [], + "area": 4578076.102644, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 93463, + "strid": "6c97b070-db8a-4192-89e2-8989a531df53", + "image_id": 204123, + "image_name": "121481.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2287.42, + 2330.358, + 365.5720000000001, + 55.289999999999964 + ], + "priority": 32, + "parents": [ + 93488 + ], + "children": [ + 93464, + 93487, + 93456, + 93485 + ], + "area": 5330507.49636, + "iscrowd": 0, + "segmentation": [], + "text": "CONCLUSION" + }, + { + "id": 93464, + "strid": "dca4ba6e-da73-4b75-800a-b8e15e8bdc6b", + "image_id": 204123, + "image_name": "121481.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2284.119, + 2409.579, + 890.4119999999998, + 259.11900000000014 + ], + "priority": 33, + "parents": [ + 93463 + ], + "children": [], + "area": 5503765.175901, + "iscrowd": 0, + "segmentation": [], + "text": "Narrative journalistic storytelling is a relevant method for the\nstudy of patient experiences in ALS. It maintains or restores\ncommunication as the ability to speak deteriorates, and it\nmay enhance patient involvement. The approach can be used\nover time to get an in-depth understanding that informs indi-\nvidual healthcare professionals’ engagement with the patient." + }, + { + "id": 93456, + "strid": "36ad1368-4841-4d09-ab2d-bd9c52ccd917", + "image_id": 204123, + "image_name": "121481.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2326.584, + 2930.827, + 823.5010000000002, + 548.6869999999999 + ], + "priority": 34, + "parents": [ + 93463 + ], + "children": [ + 93486 + ], + "area": 6818815.204968, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 93486, + "strid": "cdbd8aba-a1af-4524-b419-ab2a78b3f692", + "image_id": 204123, + "image_name": "121481.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2954.028, + 3485.088, + 196.48599999999988, + 32.210999999999785 + ], + "priority": 35, + "parents": [ + 93456 + ], + "children": [], + "area": 10295047.534464, + "iscrowd": 0, + "segmentation": [], + "text": "Photo: Bo Nymann" + }, + { + "id": 93485, + "strid": "3ac7a290-1828-4fbb-a5ea-f6eb30b68349", + "image_id": 204123, + "image_name": "121481.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2463.618, + 3583.332, + 552.4169999999999, + 53.14800000000014 + ], + "priority": 36, + "parents": [ + 93463 + ], + "children": [], + "area": 8827961.215176, + "iscrowd": 0, + "segmentation": [], + "text": "lrene Jacobsen’s story" + }, + { + "id": 93487, + "strid": "2574f14f-cd3e-44ce-99fe-7246750de535", + "image_id": 204123, + "image_name": "121481.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2325.111, + 3700.901, + 685.2860000000001, + 239.971 + ], + "priority": 37, + "parents": [ + 93463 + ], + "children": [], + "area": 8605005.625010999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 93466, + "strid": "71f633c8-2a53-4f33-a0e5-289a1820f135", + "image_id": 204123, + "image_name": "121481.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2283.166, + 4178.826, + 504.29399999999987, + 42.9399999999996 + ], + "priority": 38, + "parents": [ + 93488 + ], + "children": [ + 93465 + ], + "area": 9540953.443116, + "iscrowd": 0, + "segmentation": [], + "text": "THE COMPLETE STORIES" + }, + { + "id": 93465, + "strid": "3ede5165-07a7-4966-b309-8999b7edcc6f", + "image_id": 204123, + "image_name": "121481.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2283.251, + 4245.634, + 877.1459999999997, + 193.92699999999968 + ], + "priority": 39, + "parents": [ + 93466 + ], + "children": [], + "area": 9693848.076134, + "iscrowd": 0, + "segmentation": [], + "text": "Being ill and oneself: Six stories about living with Amyo-\ntrophic Lateral Sclerosis can be obtained upon request to the\ncorresponding author.\n\nJgrgen Jeppesen. Email: joje@rcfm.dk." + }, + { + "id": 93468, + "strid": "cf14d3cc-feee-494d-9297-c7dba921e6be", + "image_id": 204123, + "image_name": "121481.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1200.779, + 4176.996, + 475.18100000000004, + 45.302999999999884 + ], + "priority": 40, + "parents": [ + 93488 + ], + "children": [ + 93467 + ], + "area": 5015649.079884, + "iscrowd": 0, + "segmentation": [], + "text": "ACKNOWLEDGEMENTS" + }, + { + "id": 93467, + "strid": "8b6169ed-358a-4bc3-a6fd-b909b504c3a4", + "image_id": 204123, + "image_name": "121481.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1201.786, + 4246.461, + 895.9969999999998, + 255.71200000000044 + ], + "priority": 41, + "parents": [ + 93468 + ], + "children": [], + "area": 5103337.379346001, + "iscrowd": 0, + "segmentation": [], + "text": "This study was funded by the Danish Ministry of Science, In-\nnovation and Higher Education, the National Rehabilitation\nCentre for Neuromuscular Diseases, and the Neuromuscular\nPatient Association.\n\nThe authors would like to thank Annette Mahoney for trans-\nlating the stories." + }, + { + "id": 93470, + "strid": "050a0b3b-2441-41bd-b544-bc539eb1dc55", + "image_id": 204123, + "image_name": "121481.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 121.555, + 4180.017, + 273.833, + 39.26299999999992 + ], + "priority": 42, + "parents": [ + 93488 + ], + "children": [ + 93469 + ], + "area": 508101.966435, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 93469, + "strid": "dd5d6731-d0b1-4550-a655-05fa01ba0554", + "image_id": 204123, + "image_name": "121481.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 121.555, + 4247.468, + 901.031, + 214.4350000000004 + ], + "priority": 43, + "parents": [ + 93470 + ], + "children": [], + "area": 516300.97274, + "iscrowd": 0, + "segmentation": [], + "text": "Jeppesen J, Rahbek J, Gredal O, Hansen HP. How Narrative\nJournalistic Stories Can Communicate the Individual's Chal-\nlenges of Daily Living with Amyotrophic Lateral Sclerosis.\nThe Patient - Patient-Centered Outcomes Research, 2014 Sep\n18 [Epub ahead of print]. DOI 10.1007/s 40271-014-0088-6" + }, + { + "id": 1678, + "strid": "abd71b39-98c1-46e0-bb59-dfef5372316d", + "image_id": 200562, + "image_name": "10295.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 11.71, + 11.01, + 63.6, + 65.14999999999999 + ], + "priority": -1, + "parents": [], + "children": [ + 1664, + 1665, + 1663, + 1661, + 1662, + 1666, + 1660 + ], + "area": 128.9271, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 1660, + "strid": "ccaa6352-5b74-4869-869e-0a4bd80365fc", + "image_id": 200562, + "image_name": "10295.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 148.061, + 48.619, + 527.578, + 100.701 + ], + "priority": 1, + "parents": [ + 1678 + ], + "children": [], + "area": 7198.577759000001, + "iscrowd": 0, + "segmentation": [], + "text": "The AnaConDa® and Sevoflurane\nin the ICU\n\ndata on ambient pollution and staff exposure" + }, + { + "id": 1661, + "strid": "591953be-b5d5-48e1-b4b8-44c425b91811", + "image_id": 200562, + "image_name": "10295.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 126.964, + 188.335, + 417.35499999999996, + 51.16499999999999 + ], + "priority": 2, + "parents": [ + 1678 + ], + "children": [], + "area": 23911.76494, + "iscrowd": 0, + "segmentation": [], + "text": "tallied Re ela eh ald dad\nO. Thomas MD, Anesthesiologist-Intensivist\nDept. of Intensive Care, VieCuri Medical Center Venlo, the Netherlands" + }, + { + "id": 1662, + "strid": "530cd8f1-b7e8-4c81-ad17-26e262e0b0a2", + "image_id": 200562, + "image_name": "10295.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 128.036, + 280.077, + 85.42700000000002, + 12.468999999999994 + ], + "priority": 3, + "parents": [ + 1678 + ], + "children": [ + 1674, + 1673, + 1667 + ], + "area": 35859.938772, + "iscrowd": 0, + "segmentation": [], + "text": "introduction" + }, + { + "id": 1667, + "strid": "e8aecc0b-45b9-4cb1-941b-b2d93e90c01e", + "image_id": 200562, + "image_name": "10295.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 127.007, + 296.694, + 336.252, + 204.47200000000004 + ], + "priority": 4, + "parents": [ + 1662 + ], + "children": [], + "area": 37682.21485800001, + "iscrowd": 0, + "segmentation": [], + "text": "The AneConDe® {Sedana. Medical, Uppesia, Hwaden) ie a\nreflection filer that can be used to administer volatile\nanesthetics to intubated patients on a conventional ventilator\noutside the OR. We have recently implemented sevoflurane\nas a sedative in our ICU and found that litle data are\navailable on staff exposure and ambient pollution when using\nthe AnaConDa® (Fig. 1). A risk analyses was performed, as\nrequested by our occupational health service. We have\nmeasured ambient pollution, staff exposure and peak values\nof sevoflurane on all connection points of the AnaConDa®\nsystem and FlurAbsorb scavenger in a Critical Care setting\n(Fig. 2). Aim of this study was to quantity ambient pollution\nand statf exposure to sevoflurane while using the AnaConDa®\nea rete Le ecureERety ohcende:" + }, + { + "id": 1673, + "strid": "f6365191-753c-44e4-a665-45ee72ef5961", + "image_id": 200562, + "image_name": "10295.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 133.919, + 522.949, + 123.85999999999999, + 149.57100000000003 + ], + "priority": 5, + "parents": [ + 1662 + ], + "children": [ + 1675 + ], + "area": 70032.807131, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 1675, + "strid": "bbdfafbf-6a4d-4f82-8ad3-2e6ccc3a3f39", + "image_id": 200562, + "image_name": "10295.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 134.67, + 673.389, + 115.846, + 8.955000000000041 + ], + "priority": 6, + "parents": [ + 1673 + ], + "children": [], + "area": 90685.29663, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 1674, + "strid": "3d05257c-1592-46f9-bc05-3b37f0fe3e51", + "image_id": 200562, + "image_name": "10295.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 263.488, + 523.635, + 188.606, + 144.97800000000007 + ], + "priority": 7, + "parents": [ + 1662 + ], + "children": [ + 1676 + ], + "area": 137971.53888, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 1676, + "strid": "4d247234-f4d2-4f6c-9be4-702c03156eab", + "image_id": 200562, + "image_name": "10295.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 265.416, + 673.094, + 71.96499999999997, + 9.172000000000025 + ], + "priority": 8, + "parents": [ + 1674 + ], + "children": [], + "area": 178649.91710400002, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 1663, + "strid": "816dc1df-4213-4933-b6a5-bbe687451b32", + "image_id": 200562, + "image_name": "10295.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 130.728, + 705.647, + 60.521000000000015, + 13.211000000000013 + ], + "priority": 9, + "parents": [ + 1678 + ], + "children": [ + 1668, + 1670, + 1677 + ], + "area": 92247.82101600002, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 1670, + "strid": "0bbc5324-73b8-447a-b0d7-a292e81115a7", + "image_id": 200562, + "image_name": "10295.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 128.499, + 722.873, + 327.6039999999999, + 189.40200000000004 + ], + "priority": 10, + "parents": [ + 1663 + ], + "children": [], + "area": 92888.457627, + "iscrowd": 0, + "segmentation": [], + "text": "Since pollution data are patient independent and relate to\nthe integrity of the breathing circuit, only one intubated\nsubject was used to perform sampling. Air sampling was\nperformed by an independent institute (RPS). A Miran\nSapphiRe portal ambient analyzer was used for realtime\nmeasurements on eight different connecting points of the\nbreathing circuit and AnaConDa\" system, including the\nFlurAbsorb scavenger. Charcoal sorbent tubes (SKC226-\n01) were used for stationary and personal measurements\nand were analyzed in a laboratory (OSHA 103 method),\nStationary 8 hour measurements were performed on two\ndifferent locations in an ICU room (fig 2). These\nmeasurements were repeated with new sampling tubes." + }, + { + "id": 1677, + "strid": "2a4175ac-df4c-4a12-b085-ee9b81b5b4a0", + "image_id": 200562, + "image_name": "10295.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 131.593, + 922.866, + 323.937, + 206.53600000000006 + ], + "priority": 11, + "parents": [ + 1663 + ], + "children": [], + "area": 121442.705538, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 1668, + "strid": "c1fdbd80-b7e0-4279-9828-991d0583ee67", + "image_id": 200562, + "image_name": "10295.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 481.67, + 279.928, + 217.83300000000003, + 248.04200000000003 + ], + "priority": 12, + "parents": [ + 1663 + ], + "children": [], + "area": 134832.91976, + "iscrowd": 0, + "segmentation": [], + "text": "ee een ne ee\nmeasure direct exposure during an 8-hour\nshift. This was repeated by a second nurse\non @ consecutive &-hour shift with a new\nsampling tube. In this way, a total of four\nstationary, two personal and eight real time\nmeasurements were performed.\nAnalyzers were calibrated before and after\nLaboratory analyses were\naccording to ISOINEN standards. The\nSwedish occupational exposure guidelines\nwere used as a reference, since no national\nguidelines are avaliable. The exposure limit\nis Spm (ime weighted average (TWA)\n42mglm’ over an Shour period), North\nAmerican quidelines are more strict, with a\nmaximum of 2pm, while in the United\nKingdom it is more. liberal, allowing\naane ements eet" + }, + { + "id": 1664, + "strid": "61fa6c37-cbed-4a84-844e-815ccc3824b3", + "image_id": 200562, + "image_name": "10295.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 482.97, + 556.147, + 44.90700000000004, + 10.706999999999994 + ], + "priority": 13, + "parents": [ + 1678 + ], + "children": [ + 1669 + ], + "area": 268602.31659000006, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 1669, + "strid": "bcc63ec3-a861-42ae-af81-ab4904aeab6a", + "image_id": 200562, + "image_name": "10295.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 482.692, + 569.696, + 217.67499999999995, + 104.73699999999997 + ], + "priority": 14, + "parents": [ + 1664 + ], + "children": [], + "area": 274987.70163200004, + "iscrowd": 0, + "segmentation": [], + "text": "Our results are summarized in table 1. Time\nweighted measurements are expressed as\na percentage of exposure limits (NEN 689\nmodel). An exceeding can be ruled out i\nconcentrations are <10% of exposure limits,\nWe clearly show that peak concentrations\nand TWA are far below the allowed\nneninalionel eemane irais," + }, + { + "id": 1665, + "strid": "46a97d6c-fdc0-4178-b9a1-46b3a4c051ff", + "image_id": 200562, + "image_name": "10295.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 482.68, + 701.935, + 65.75600000000003, + 11.644000000000005 + ], + "priority": 15, + "parents": [ + 1678 + ], + "children": [ + 1671 + ], + "area": 338809.98579999997, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion" + }, + { + "id": 1671, + "strid": "cfec362d-4ddd-483b-960a-d41af85e260f", + "image_id": 200562, + "image_name": "10295.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 481.646, + 716.916, + 217.89799999999997, + 115.88400000000001 + ], + "priority": 16, + "parents": [ + 1665 + ], + "children": [], + "area": 345299.723736, + "iscrowd": 0, + "segmentation": [], + "text": "TNS GApORES 15 VOR S enesieics Shout\nbe reduced to a level as low as reasonably\nachievable’ (ALARA). Local differences in\nICU's necessitate quantification of exposure\nprior to routine use, in order to guarantee a\nsafe work environment. Furthermore,\nprotocols should be used to ensure a\nstandard way of care when using volatile\nanesthetics." + }, + { + "id": 1666, + "strid": "9b352aac-2a0b-4b70-8736-8365823775e5", + "image_id": 200562, + "image_name": "10295.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 482.927, + 861.613, + 66.66600000000005, + 11.057000000000016 + ], + "priority": 17, + "parents": [ + 1678 + ], + "children": [ + 1672 + ], + "area": 416096.18125100003, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 1672, + "strid": "c8a5eab6-e3fd-4b25-917d-533680e22568", + "image_id": 200562, + "image_name": "10295.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 482.14, + 875.891, + 218.09699999999998, + 119.21100000000001 + ], + "priority": 18, + "parents": [ + 1666 + ], + "children": [], + "area": 422302.08674, + "iscrowd": 0, + "segmentation": [], + "text": "We concluded that sedation with\nsevoflurane and the AnaConDa® system\nwith the FlurAbsorb scavenger is safe in an\nICU setting. Occupational exposure is\nnegligible and meets _infornational\nstandards. These data highly contributed to\nstaff safely perception and awareness. Our\ndata may be helpful to those who want to\nfirgleanient-volallle srieethedion In ther GUL" + }, + { + "id": 11054, + "strid": "020db822-c3de-453c-8b6c-4472ad570d2a", + "image_id": 200946, + "image_name": "11354.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 80.45, + 72.03, + 277.37, + 208.03 + ], + "priority": -1, + "parents": [], + "children": [ + 11057, + 11069, + 11066, + 11060, + 11063, + 11056, + 11055 + ], + "area": 5794.8135, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 11055, + "strid": "baea6930-7131-4ecb-8bab-078963a5547c", + "image_id": 200946, + "image_name": "11354.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 556.859, + 54.556, + 2630.68, + 304.374 + ], + "priority": 1, + "parents": [ + 11054 + ], + "children": [], + "area": 30379.999604, + "iscrowd": 0, + "segmentation": [], + "text": "QCFALLSequencing" + }, + { + "id": 11056, + "strid": "8d89a210-6b25-4a1e-a613-740bd37840bc", + "image_id": 200946, + "image_name": "11354.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 359.806, + 360.805, + 2812.767, + 352.724 + ], + "priority": 2, + "parents": [ + 11054 + ], + "children": [], + "area": 129819.80382999999, + "iscrowd": 0, + "segmentation": [], + "text": "Steven Wingett', Felix Krueger’, Philip Ewels* and Simon Andrews'\n‘Bioinformatics Group, The Babraham Institute, Cambridge CB22 3AT, UK\n“Department of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm\nUniversity, Stockholm 106 91, Sweden" + }, + { + "id": 11057, + "strid": "05e49e0a-3dbd-4e56-b524-890a5835ab4c", + "image_id": 200946, + "image_name": "11354.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 601.607, + 810.949, + 434.953, + 65.19200000000001 + ], + "priority": 3, + "parents": [ + 11054 + ], + "children": [ + 11058 + ], + "area": 487872.59504299995, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 11058, + "strid": "c4caa929-0919-49cf-8cac-1d68f7f0a954", + "image_id": 200946, + "image_name": "11354.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 37.569, + 941.543, + 1542.597, + 1314.9859999999999 + ], + "priority": 4, + "parents": [ + 11057 + ], + "children": [], + "area": 35372.828967, + "iscrowd": 0, + "segmentation": [], + "text": "Reaching valid conclusions from DNA sequencing experiments\nrequires accurate results and a thorough understanding of the data,\nyet we often see researchers misinterpreting artefacts as genuine\nfindings and consequently presenting incorrect conclusions and\n\nwasting time chasing false leads.\n\nPerhaps more frustrating still is the fact that many different\nresearchers are being adversely affected by the same artefacts, or\nmaking similar mistakes when interpreting DNA sequencing results.\nAt present, there is a lack of resources available to help scientists\navoid these pitfalls, and an unmet need for a freely available central\nresource clearly documenting the most commonly encountered and\n\nproblematic issues affecting those undertaking DNA sequencing.\n\nTo address these problems, we developed the website QC Fail." + }, + { + "id": 11060, + "strid": "6f11fdcd-7061-486a-91f2-cb72691d7eeb", + "image_id": 200946, + "image_name": "11354.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 719.593, + 2308.617, + 196.47199999999998, + 69.29199999999992 + ], + "priority": 5, + "parents": [ + 11054 + ], + "children": [ + 11068, + 11064, + 11059 + ], + "area": 1661264.632881, + "iscrowd": 0, + "segmentation": [], + "text": "Aims" + }, + { + "id": 11064, + "strid": "8d73f4d1-5a49-40e1-9b4b-3a05be87e8b7", + "image_id": 200946, + "image_name": "11354.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 37.709, + 2448.674, + 1539.611, + 774.8789999999999 + ], + "priority": 6, + "parents": [ + 11060 + ], + "children": [], + "area": 92337.04786600001, + "iscrowd": 0, + "segmentation": [], + "text": "When we encounter a sequencing problem which may be of interest\nto the wider life sciences community, we record our experiences on\nthe QC Fail website. Each article typically discusses how a problem\nwas identified, whether we determined the cause and what measures\nshould be taken to improve the situation. In addition, we make\navailable example datasets for people to download and analyse\nthemselves and perhaps use in the development of processing or\nQC tools. These datasets should also prove useful for teaching\n\npurposes. This poster summarises two recently published stories." + }, + { + "id": 11059, + "strid": "f6c93981-952f-479d-b5e5-c45ce9a0cc04", + "image_id": 200946, + "image_name": "11354.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 39.776, + 3270.499, + 766.035, + 607.1990000000001 + ], + "priority": 7, + "parents": [ + 11060 + ], + "children": [], + "area": 130087.368224, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 11068, + "strid": "d9ad2a36-5cad-4395-86ef-4ab6eae748ec", + "image_id": 200946, + "image_name": "11354.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 828.017, + 3268.889, + 760.9370000000001, + 512.3630000000003 + ], + "priority": 8, + "parents": [ + 11060 + ], + "children": [], + "area": 2706695.6631130003, + "iscrowd": 0, + "segmentation": [], + "text": "QC Fail website screenshot\n\nAs we encounter new sequencing-related problems we\npost our experiences on the website. We allow visitors\nto comment on our stories and share their experiences\nwith our readers. The site now hosts a wealth of\ninformation on how to improve experiments, and\nprovides a great way for researchers to get in contact\nwith people who may have already encountered a\n\nproblem similar to their own." + }, + { + "id": 11063, + "strid": "c095a911-ec2d-4be4-a9d3-bb9b7c54bbba", + "image_id": 200946, + "image_name": "11354.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1982.008, + 809.292, + 1011.5179999999998, + 79.87699999999995 + ], + "priority": 9, + "parents": [ + 11054 + ], + "children": [ + 11073, + 11065, + 11071, + 11061 + ], + "area": 1604023.218336, + "iscrowd": 0, + "segmentation": [], + "text": "Story 1 - DNA contamination" + }, + { + "id": 11061, + "strid": "2842c85a-1e48-4d8e-b3db-13e1e0c9e574", + "image_id": 200946, + "image_name": "11354.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1704.245, + 939.826, + 1556.993, + 594.665 + ], + "priority": 10, + "parents": [ + 11063 + ], + "children": [], + "area": 1601693.76137, + "iscrowd": 0, + "segmentation": [], + "text": "Problem: Cross mapping artefacts owing to DNA contamination from\n“foreign” species.\n\nSolution: Validate the sample is as expected using tools such as\nFastQ Screen to map sequences against a panel of reference\ngenomes. In the example below, the supposedly human sample was\ncontaminated with E. coli DNA. Researchers should troubleshoot\n\ntheir protocols to identify and remove such contaminants." + }, + { + "id": 11065, + "strid": "c01ee017-89f2-4c3c-bfda-482d103a52f4", + "image_id": 200946, + "image_name": "11354.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1705.247, + 1592.57, + 1043.785, + 538.5399999999997 + ], + "priority": 11, + "parents": [ + 11063 + ], + "children": [], + "area": 2715725.21479, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 11071, + "strid": "b741031f-2d16-4b7e-8aac-d5b7db0b0786", + "image_id": 200946, + "image_name": "11354.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2778.536, + 1601.008, + 485.0529999999999, + 448.885 + ], + "priority": 12, + "parents": [ + 11063 + ], + "children": [], + "area": 4448458.364288, + "iscrowd": 0, + "segmentation": [], + "text": "Output from FastQ Screen\n\nThe graph shows the result of\nmapping reads against the\nexpected human genome and four\npotential sources of\ncontamination. Unexpectedly, just\nover 60% of the reads mapped\n\nonly to the E. coli genome." + }, + { + "id": 11073, + "strid": "99a9dd0d-9eaf-4f03-80be-bcfd12520d08", + "image_id": 200946, + "image_name": "11354.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1717.405, + 2182.709, + 1495.334, + 37.15299999999979 + ], + "priority": 13, + "parents": [ + 11063 + ], + "children": [], + "area": 3748595.3501449996, + "iscrowd": 0, + "segmentation": [], + "text": "The tool FastQ Screen may be downloaded from : http://www.bioinformatics.babraham.ac.uk/projects" + }, + { + "id": 11069, + "strid": "e3dd3265-18b4-4e84-86b0-5116142dfe7d", + "image_id": 200946, + "image_name": "11354.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1800.473, + 2310.02, + 1372.676, + 77.59000000000015 + ], + "priority": 14, + "parents": [ + 11054 + ], + "children": [ + 11062, + 11067, + 11070 + ], + "area": 4159128.6394599997, + "iscrowd": 0, + "segmentation": [], + "text": "Story 2 - patterned flow cell duplicates" + }, + { + "id": 11067, + "strid": "d173d7dc-efa9-4bc1-962f-2a11c75e1e19", + "image_id": 200946, + "image_name": "11354.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1704.214, + 2448.778, + 1560.234, + 863.835 + ], + "priority": 15, + "parents": [ + 11069 + ], + "children": [], + "area": 4173241.7504919996, + "iscrowd": 0, + "segmentation": [], + "text": "Problem: Although the new Illumina patterned flow cells generate\nmany more sequence reads than the previous generation design, a\nsignificant proportion of such reads may be duplicates. These\nartefacts, specific to this new patterned design, reduce sequencing\ndepth and could skew experimental results.\n\nSolution: These duplicates are positioned in close proximity to one\nanother on a flowcell and so may be removed using a distance filter\n(similar to the removal of “optical duplicates” performed by tools such\nas Picard, but requiring an increased minimum allowed separation\n\ndistance)." + }, + { + "id": 11062, + "strid": "a9450e1a-eec9-47c2-8817-0f77f2dd33af", + "image_id": 200946, + "image_name": "11354.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1722.925, + 3340.197, + 892.9619999999998, + 539.0230000000001 + ], + "priority": 16, + "parents": [ + 11069 + ], + "children": [], + "area": 5754908.916225, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 11070, + "strid": "ab49005f-064a-4ff4-af4d-361b3bf0f5f3", + "image_id": 200946, + "image_name": "11354.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2632.724, + 3337.629, + 630.0250000000001, + 456.89699999999993 + ], + "priority": 17, + "parents": [ + 11069 + ], + "children": [], + "area": 8787055.971396001, + "iscrowd": 0, + "segmentation": [], + "text": "Plot showing the spatial separation of\nduplicates relative to one another\n\nOne read is set at the origin, and the relative\nposition of its duplicate is determined using\nthe co-ordinate system recorded in the FASTQ\nfile. The plot reveals the ordered array of\nindividual nanowells integral to this new\n\ntechnology." + }, + { + "id": 11066, + "strid": "70712f80-e95a-4524-85fd-9512a47049d6", + "image_id": 200946, + "image_name": "11354.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1317.533, + 3915.491, + 669.7139999999999, + 102.99400000000014 + ], + "priority": 18, + "parents": [ + 11054 + ], + "children": [ + 11072 + ], + "area": 5158788.603703, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 11072, + "strid": "dcd5c311-de04-444a-8dfe-6b25d334d857", + "image_id": 200946, + "image_name": "11354.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 42.553, + 4070.867, + 3210.33, + 235.41600000000017 + ], + "priority": 19, + "parents": [ + 11066 + ], + "children": [], + "area": 173227.603451, + "iscrowd": 0, + "segmentation": [], + "text": "The QC Fail website already provides an invaluable resource to help other scientists plan, perform and analyse sequencing experiments. Our\nbioinformatics facility is continuing to develop the site as we, and our readers, encounter interesting sequencing problems. Although the stories\n\ncurrently focus on sequencing-related matters, we intend to report new technology trends as they develop." + }, + { + "id": 165095, + "strid": "9e3f1a8a-69fb-4bfa-80f4-faef45f0038a", + "image_id": 206939, + "image_name": "6688.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 174.25, + 150.78, + 241.37, + 234.67 + ], + "priority": -1, + "parents": [], + "children": [ + 165084, + 165088, + 165085, + 165090, + 165086, + 165089, + 165082, + 165083, + 165087, + 165081 + ], + "area": 26273.415, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 165081, + "strid": "5b98c293-f6c4-44d2-8930-cff350a250ae", + "image_id": 206939, + "image_name": "6688.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 521.769, + 151.286, + 2250.884, + 245.22499999999997 + ], + "priority": 1, + "parents": [ + 165095 + ], + "children": [], + "area": 78936.34493400001, + "iscrowd": 0, + "segmentation": [], + "text": "VISUAL-SPATIAL-MOTOR INTEGRATION IN A CROSS-SECTION\nOF PRIMARY-AGED CHILDREN: IMPLICATIONS FOR\nASSESSING RISK OF DYSLEXIA" + }, + { + "id": 165082, + "strid": "ec2d3b03-4c1e-40f3-827f-41e8605bc188", + "image_id": 206939, + "image_name": "6688.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 832.786, + 414.454, + 1628.85, + 191.39500000000004 + ], + "priority": 2, + "parents": [ + 165095 + ], + "children": [], + "area": 345151.488844, + "iscrowd": 0, + "segmentation": [], + "text": "Ms Barbara Piotrowska', Dr Alexandra Willis! , Dr Rory MacLean’,\nDr Jennifer Murray! & Prof. Jon M. Kerridge?\n\n‘School of Life, Sport, and Social Sciences & 2School of Computing,\nEdinburgh Napier University, Scotland, UK." + }, + { + "id": 165083, + "strid": "46dce15d-0d7c-47ae-8f23-8e97af82776e", + "image_id": 206939, + "image_name": "6688.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 81.996, + 724.232, + 337.334, + 51.898000000000025 + ], + "priority": 3, + "parents": [ + 165095 + ], + "children": [ + 165061 + ], + "area": 59384.127071999996, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 165061, + "strid": "cf8b38ca-7492-47b0-896f-3020d2d95024", + "image_id": 206939, + "image_name": "6688.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 90.207, + 805.959, + 825.357, + 647.841 + ], + "priority": 4, + "parents": [ + 165083 + ], + "children": [], + "area": 72703.14351299999, + "iscrowd": 0, + "segmentation": [], + "text": "Dyslexia is a common condition characterized by difficulties with reading\nand writing despite adequate intelligence, education and motivation. Many\nindividuals with dyslexia also have problems integrating visual information\nover space and time, and /or motor control: however, whether sensory and\nmotor deficits underlie phonological difficulties in dyslexia, or merely co-\nexist with them, remains a topic of debate. We used a novel, computer-\nbased “dot-to-dot” (DtD) task to explore visual-motor integration in 253\nchildren (aged 4 — 10 yrs, m=5.69; 114 females) from three primary\nschools in Edinburgh, UK, and its relationship with phonological and\ncognitive skills known to be compromised in dyslexia. We found that: (1)\nDtD accuracy was significantly correlated with phonological processing,\nrapid automatized naming (RAN) and digit span (arguably the best\npredictors of dyslexia); (2) DtD accuracy was a predictive variable of\nphonological processing adding14% of the variance to the model, (3)\nchildren deemed at “high” risk of dyslexia according to existing screening\ntools (e.g. LUCID-Rapid) performed significantly less accurately than\nthose deemed at “low” risk. Follow-up testing of the youngest, pre-reading\nchildren will indicate whether or not poor visual-motor integration\nperformance predicts later reading problems." + }, + { + "id": 165084, + "strid": "019e3a35-4f10-4e64-aa7d-c6ca7c0c02d5", + "image_id": 206939, + "image_name": "6688.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 85.049, + 1508.613, + 493.842, + 47.2829999999999 + ], + "priority": 5, + "parents": [ + 165095 + ], + "children": [ + 165065 + ], + "area": 128306.02703700002, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 165065, + "strid": "1ccf9d45-f7e3-431b-b07a-1a02e03c36c1", + "image_id": 206939, + "image_name": "6688.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 89.81, + 1591.377, + 821.9160000000002, + 1646.306 + ], + "priority": 6, + "parents": [ + 165084 + ], + "children": [], + "area": 142921.56837, + "iscrowd": 0, + "segmentation": [], + "text": "“Dyslexia is a specific learning difficulty that mainly affects\nthe development of literacy and language-related skills. It is\nlikely to be present at birth and to be life-long in its effects. It\nis characterised by difficulties with phonological processing,\nrapid naming, working memory, processing speed, and the\nautomatic development of skills that may not match up to an\nindividual's other cognitive abilities.”\n\nThe dominant theory of dyslexia focuses on the phonological\ndeficit that characterizes the condition 2. However, many\npeople with dyslexia also show deficits in a range of lower-\nlevel perceptual, attentional, and motor tasks: this has led to\na second group of theories that see phonological deficits as\nsecondary to a general sensory or sensorimotor deficit,\nunderpinned by abnormalities in magnocellular °, dorsal\nstream 4, cerebellar development 5, or attention .\n\nAlthough the cause of dyslexia is debated, there is a\nwidespread consensus that early identification and\nintervention are crucial in both language remediation and in\nlimiting the low self-esteem and behavioural difficulties often\nreported in unrecognized dyslexia. However, identifying\ndyslexia is difficult, time consuming, and expensive: as such,\nthe formal identification in UK schools typically occurs long\nafter children have failed to learn to read ’.\n\nIf sensorimotor problems do underlie dyslexia, they should\nbe demonstrable in young children, before they learn to\nread. The few longitudinal studies published on this topic do\nindeed suggest that this may be the case, and warrant\nfurther exploration ® .\n\nHere, we report on the first phase of a longitudinal study of a\nnovel “dot-to-dot” task that could provide a quick, simple and\ncheap method of estimating risk of dyslexia. Because the\ntask relies on sensorimotor, rather than phonological skills, it\nmay be used to screen children before they learn to read,\nand in children whose first language is not English. The task\nwas developed from a serendipitous observation (during a\npublic engagement demonstration of an infra-red tracking\nsystem) that adults tended to be slower and make more\nerrors in a large-scale dot-tracking task." + }, + { + "id": 165086, + "strid": "5b3c0108-7919-4be7-a6e4-fac6d69ac0c8", + "image_id": 206939, + "image_name": "6688.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 82.504, + 3308.686, + 707.751, + 57.2829999999999 + ], + "priority": 7, + "parents": [ + 165095 + ], + "children": [ + 165076 + ], + "area": 272979.82974400005, + "iscrowd": 0, + "segmentation": [], + "text": "RESEARCH\n\nQUESTIO\n\nNS" + }, + { + "id": 165076, + "strid": "8b9404ec-f447-48df-b928-48e30ac4909d", + "image_id": 206939, + "image_name": "6688.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 86.968, + 3390.201, + 790.94, + 252.30200000000013 + ], + "priority": 8, + "parents": [ + 165086 + ], + "children": [], + "area": 294839.000568, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 165087, + "strid": "7829d53e-ebdb-4e5f-ac48-81283dc0c394", + "image_id": 206939, + "image_name": "6688.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 76.133, + 3686.966, + 315.376, + 52.139000000000124 + ], + "priority": 9, + "parents": [ + 165095 + ], + "children": [ + 165063, + 165069, + 165062, + 165079, + 165071, + 165073, + 165072, + 165070 + ], + "area": 280699.782478, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 165069, + "strid": "2c4f811c-eaea-4efa-80d7-b6b44b0159aa", + "image_id": 206939, + "image_name": "6688.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 85.724, + 3773.158, + 824.451, + 141.27700000000004 + ], + "priority": 10, + "parents": [ + 165087 + ], + "children": [], + "area": 323450.196392, + "iscrowd": 0, + "segmentation": [], + "text": "Participants\n\n253 children (114 females) aged between 4 and 10 years\n(mean = 5.61; SD = 1.79) have taken part from three primary\nschools in Edinburgh." + }, + { + "id": 165070, + "strid": "8237246a-4dd2-481f-aac7-a5d63ac67cc2", + "image_id": 206939, + "image_name": "6688.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 84.715, + 3919.48, + 831.514, + 362.2739999999999 + ], + "priority": 11, + "parents": [ + 165087 + ], + "children": [], + "area": 332038.74820000003, + "iscrowd": 0, + "segmentation": [], + "text": "Procedure\n\nAll participants completed the DtD task as well as a battery of\ncognitive and dyslexia screening tests.\n\nChildren were tested individually over two sessions, lasting\n20-30 min each, in a quiet room at their school. During the\nsession A, children completed the dot-to dot task and LUCID\nscreening test; during the session B, they completed the\ncognitive tasks (Weschler) and dyslexia screening subtests\n(Fawcett & Nicolson). Sessions order was randomized\nacross participants." + }, + { + "id": 165071, + "strid": "1365d73d-4e28-4217-92ce-2600b11b650b", + "image_id": 206939, + "image_name": "6688.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 85.064, + 4285.539, + 825.989, + 140.09699999999975 + ], + "priority": 12, + "parents": [ + 165087 + ], + "children": [], + "area": 364545.089496, + "iscrowd": 0, + "segmentation": [], + "text": "Analysis\n\nStatistical analysis involved looking for relationships between\nour task and other cognitive and screening tasks and a\ncomparison of children at low and high risk of dyslexia." + }, + { + "id": 165062, + "strid": "e6c67b19-58d6-410e-b337-4034d9700220", + "image_id": 206939, + "image_name": "6688.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 986.85, + 726.656, + 1325.7040000000002, + 412.85300000000007 + ], + "priority": 13, + "parents": [ + 165087 + ], + "children": [], + "area": 717100.4735999999, + "iscrowd": 0, + "segmentation": [], + "text": "Materials\n\nDot-to-dot task (visual-spatial-motor integration)\n\nParticipants were asked to look at a sequence of dots on a display monitor and draw a line as\nquickly and accurately as possible between them on an adjacent touch-screen tablet using a\nstylus (see Figure 1). Single dots appeared sequentially, at a new location, as soon as the stylus\nmoved sufficiently close to the previous dot. Participants completed three trials for each of 8 and 9\ndot displays, using both the dominant and non-dominant hand. The sequence of trials was\nrandomized. We measured: (1) the maximum error between the drawn line and the line of best\nfit in the first sector of the pattern (DtD First Sector Max Error); (2) the total error between the\ndrawn line compared to the line of best fit over the whole pattern (DtD Total Error) ; and (3) the\ntime taken to complete the task (DtD Time)." + }, + { + "id": 165079, + "strid": "a8ee6785-d03f-4cac-94a8-14da8bf1e7c3", + "image_id": 206939, + "image_name": "6688.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1000.511, + 1157.967, + 812.49, + 582.5259999999998 + ], + "priority": 14, + "parents": [ + 165087 + ], + "children": [ + 165094 + ], + "area": 1158558.721137, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 165094, + "strid": "42e8948d-dd30-4602-8241-b5f33cfa72ab", + "image_id": 206939, + "image_name": "6688.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 989.547, + 1765.243, + 325.453, + 23.24700000000007 + ], + "priority": 15, + "parents": [ + 165079 + ], + "children": [], + "area": 1746790.914921, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1: The dot-to-dot task." + }, + { + "id": 165063, + "strid": "5e0aa993-e006-4df1-890d-f31cc5c10454", + "image_id": 206939, + "image_name": "6688.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1819.425, + 1193.54, + 457.3320000000001, + 563.873 + ], + "priority": 16, + "parents": [ + 165087 + ], + "children": [], + "area": 2171556.5145, + "iscrowd": 0, + "segmentation": [], + "text": "(a) Experimental set up showing the\ndisplay monitor, touch-screen tablet, and\nstylus. Participants looked at the top\npanel of the display and joined up the\ndots on the tablet below with the stylus.\n(b) Example of the display screen during\na practice trial.\n\n(c) Example of the output from a single\ntrial, for one participant (8-dot condition).\nThe grey line shows the line of best fit,\ncalculated by the software. The coloured\nline shows the line drawn by the\nparticipant. Note that in this example, the\nDtD First Sector Max Error is very large\n(see red line): the yellow and red\nsections of the line indicate that the\npoints fell beyond 1 and 2 SD of the\nmean, respectively, for the sample as a\nwhole." + }, + { + "id": 165072, + "strid": "431675f0-cc7c-4ce8-b8db-40b3478774c4", + "image_id": 206939, + "image_name": "6688.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 987.655, + 1808.474, + 562.7839999999999, + 31.656999999999925 + ], + "priority": 17, + "parents": [ + 165087 + ], + "children": [], + "area": 1786148.38847, + "iscrowd": 0, + "segmentation": [], + "text": "Cognitive and dyslexia screening tests" + }, + { + "id": 165073, + "strid": "b111b631-18e0-4e05-b269-abf029d570db", + "image_id": 206939, + "image_name": "6688.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 975.528, + 1842.833, + 1349.6830000000002, + 418.73799999999983 + ], + "priority": 18, + "parents": [ + 165087 + ], + "children": [ + 165093 + ], + "area": 1797735.1908240002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 165093, + "strid": "1d2295a9-8503-4431-8de5-4afb183588b0", + "image_id": 206939, + "image_name": "6688.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 986.669, + 2260.057, + 1302.888, + 65.38400000000001 + ], + "priority": 19, + "parents": [ + 165073 + ], + "children": [], + "area": 2229928.1801329996, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1: Cognitive tests used in the study from batteries by Lucid Research Ltd (L), Fawcett & Nicolson screening tool\n(F&N) and subtests from Wechsler’s Intelligence scale (W)." + }, + { + "id": 165085, + "strid": "96f45afd-4dee-402c-86be-ec4c9be05b36", + "image_id": 206939, + "image_name": "6688.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 982.766, + 2402.572, + 268.043, + 49.88599999999997 + ], + "priority": 20, + "parents": [ + 165095 + ], + "children": [ + 165066, + 165067, + 165075, + 165074, + 165080, + 165068 + ], + "area": 2361166.0741520002, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 165066, + "strid": "cc16ebda-2369-4897-9361-16d35dacd482", + "image_id": 206939, + "image_name": "6688.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 984.904, + 2480.68, + 1286.732, + 146.5369999999998 + ], + "priority": 21, + "parents": [ + 165085 + ], + "children": [], + "area": 2443231.65472, + "iscrowd": 0, + "segmentation": [], + "text": "Correlation\n\nThe First Sector Max Error measure of performance on our dot-to-dot task was significantly\ncorrelated with both Phonological Awareness and Rapid Automatized Naming (RAN), arguably\nthe two most powerful predictors of reading success in children." + }, + { + "id": 165074, + "strid": "a2c6564c-0b32-4ed2-8072-a7fcb3a05050", + "image_id": 206939, + "image_name": "6688.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 979.772, + 2632.246, + 1347.408, + 237.08399999999983 + ], + "priority": 22, + "parents": [ + 165085 + ], + "children": [ + 165092 + ], + "area": 2579000.927912, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 165092, + "strid": "825952a4-8fa7-455b-97d6-22c14e3cdf53", + "image_id": 206939, + "image_name": "6688.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 979.056, + 2874.749, + 1249.5520000000001, + 55.766999999999825 + ], + "priority": 23, + "parents": [ + 165074 + ], + "children": [], + "area": 2814540.256944, + "iscrowd": 0, + "segmentation": [], + "text": "Table 2. Pearson's correlations. (1) tests taken from Fawcett & Nicolson screening tool; (2) tests from Wechsler’s\nIntelligence Scale. Significance (two-tailed): * p < 0.05; ** p<0.01" + }, + { + "id": 165067, + "strid": "e6bf4823-4f08-41e1-b8da-7b071ad7fce4", + "image_id": 206939, + "image_name": "6688.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 984.904, + 2950.993, + 1328.6, + 181.42599999999993 + ], + "priority": 24, + "parents": [ + 165085 + ], + "children": [], + "area": 2906444.809672, + "iscrowd": 0, + "segmentation": [], + "text": "Regression\nMultiple stepwise regression analysis was used to test if the performance on DtD test and the\n\ncognitive tests would predict performance on a phonological processing test (Fawcett & Nicolson),\narguably the best indicator of dyslexia. The overall model proved significant in that adjusted\nR2=.42, F(3, 231) = 57.35, p <.001. It was found that:" + }, + { + "id": 165075, + "strid": "7fa263ef-ed47-4d9f-ad21-5e24c654f7e9", + "image_id": 206939, + "image_name": "6688.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 987.121, + 3134.816, + 1309.643, + 182.28999999999996 + ], + "priority": 25, + "parents": [ + 165085 + ], + "children": [], + "area": 3094442.704736, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 165068, + "strid": "4daec2ec-7b49-42d1-84da-d02aad3b933a", + "image_id": 206939, + "image_name": "6688.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 986.3, + 3357.109, + 1335.5779999999997, + 365.6439999999998 + ], + "priority": 26, + "parents": [ + 165085 + ], + "children": [], + "area": 3311116.6067, + "iscrowd": 0, + "segmentation": [], + "text": "Comparison between low and high risk of dyslexia groups\n\nGroups of children classified as “high” (n=74) and “low” (n=52) risk of dyslexia on the basis of\ntheir scores on LUCID-Rapid were compared. The remaining children (n=127) were identified as at\n‘medium’ risk and were not included in this analysis. Independent-samples t-tests revealed that\nchildren deemed at high risk of dyslexia made significantly greater maximum errors in the first\nsector of the pattern and made more errors over the whole pattern, compared with low-risk\nchildren: however, there was no significant difference in time taken to complete the task. It has\nalso been revealed that children deemed at high risk of dyslexia perform significantly worse on\nBlock Design, Matrix Reasoning, Similarities, Digit Span, RAN, Phonological Awareness and Bead\nThreading tasks (see Figure 2)." + }, + { + "id": 165080, + "strid": "c340296b-824e-4ceb-a200-142ca229ff0b", + "image_id": 206939, + "image_name": "6688.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1023.702, + 3740.021, + 1294.5469999999998, + 689.9789999999998 + ], + "priority": 27, + "parents": [ + 165085 + ], + "children": [ + 165091 + ], + "area": 3828666.977742, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 165091, + "strid": "0a0e405f-9162-4bc3-a1b0-60b87d56423f", + "image_id": 206939, + "image_name": "6688.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1025.546, + 4446.931, + 1117.644, + 50.97999999999956 + ], + "priority": 28, + "parents": [ + 165080 + ], + "children": [], + "area": 4560532.299326, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2: Children’s performance on DtD and cognitive tests, grouped according to risk of dyslexia.\nError bars indicate +1 SEM. Differences are significant at p < 0.05 (*): p < 0.01 (**): p < 0.001 (***)." + }, + { + "id": 165090, + "strid": "83474cdb-11a3-4bcd-b55a-f4811cb25400", + "image_id": 206939, + "image_name": "6688.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2384.507, + 722.413, + 375.97800000000007, + 50.129999999999995 + ], + "priority": 29, + "parents": [ + 165095 + ], + "children": [ + 165064 + ], + "area": 1722598.8553910002, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 165064, + "strid": "536364cd-fd59-4da0-9720-b2d5f3814f98", + "image_id": 206939, + "image_name": "6688.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2388.213, + 805.15, + 843.9720000000002, + 1870.8939999999998 + ], + "priority": 30, + "parents": [ + 165090 + ], + "children": [], + "area": 1922869.69695, + "iscrowd": 0, + "segmentation": [], + "text": "In the current study, the performance on a novel task was\ntested against the main predictors of dyslexia. The task, as\nwe believe, involves visuo-spatial-motor integration systems,\nthat have been earlier shown to be dysfunctional and could be\nexplained by various theories looking at magnocellular/ dorsal\nstream, cerebellar or attentional deficits.\n\nWe found that performance on our dot-to-dot (DtD) task was\nsignificantly correlated with tests of phonological processing,\nworking memory (e.g. digit span), and processing speed (e.g.\nRAN) — all known to be compromised in dyslexia. Also, the\nFirst Sector Max Error measure could add some prediction to\na significant model explaining the variance of phonological\nprocessing scores.\n\nWe also found that children deemed at “high” risk of dyslexia\non the basis of existing screening tests performed significantly\nworse in our DtD task (as well as in tasks of phonological\nprocessing, working memory, and processing speed)\ncompared with their low-risk counterparts. These results\nprovide further support for sensorimotor theories of dyslexia.\n\nHowever, we also found that performance on tasks of\nperceptual reasoning was also associated with those of\nphonological processing, working memory and processing\nspeed, as well as the DtD, which might suggest that more\ngeneral cognitive ability may be a confounding variable in\nthese effects.\n\nFurthermore, the proportion of children deemed at “high” risk\nof dyslexia (29%) on the basis of the LUCID-Rapid screening\ntool was considerably higher than the 10% widely believed to\naffect the UK population as a whole. One of the schools we\ntested at was in one of the most economically and socially\ndisadvantaged areas in Scotland®, and another had the\ngreatest numbers of English as an Additional Language\npupils: it may be that our sample contained higher proportions\nof “garden-variety poor readers” or developing readers. This\nsuggests merit in exploring the possibility of non-phonological\nscreening tests like ours in the early assessment of dyslexia.\n\nNext, we plan to (1) follow up the youngest, pre-reading\nchildren to see if poorer performance on the DtD task predicts\nlater reading success; (2) adapt the DtD task to better bias\nperformance to magnocellular or dorsal stream functioning —\nfor example, by increasing the speed and complexity of the\ndot displays and by increasing the attentional demand of the\ntask." + }, + { + "id": 165089, + "strid": "6b7cb720-5e0c-4eaa-a20f-b226355a8085", + "image_id": 206939, + "image_name": "6688.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2381.143, + 2748.278, + 450.5659999999998, + 50.57400000000007 + ], + "priority": 31, + "parents": [ + 165095 + ], + "children": [ + 165077 + ], + "area": 6544042.921754, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 165077, + "strid": "7d205375-61b6-4654-9485-8e86309fd2be", + 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into the Location and Quality of\nPremonitory Urges" + }, + { + "id": 114516, + "strid": "6f9f5e42-cca1-43e6-9bfe-1053f8057817", + "image_id": 204950, + "image_name": "13582.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 193.072, + 855.652, + 2277.69, + 104.28200000000004 + ], + "priority": 2, + "parents": [ + 114558 + ], + "children": [], + "area": 165202.442944, + "iscrowd": 0, + "segmentation": [], + "text": "Ewgeni Jakubovski*, Jana Essing*, Nikolas Psithakis*, Sinan Necdet Cevirme?, Kirsten Muller-Vahl*\n\n1Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Germany" + }, + { + "id": 114517, + "strid": "c4206330-b55b-43f2-82a5-0d9acb8af397", + "image_id": 204950, + "image_name": "13582.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 96.257, + 1060.703, + 323.836, + 58.298 + ], + "priority": 3, + "parents": [ + 114558 + ], + "children": [ + 114535 + ], + "area": 102100.088671, + "iscrowd": 0, + "segmentation": [], + "text": "Background:" + }, + { + "id": 114535, + "strid": "06b27250-0001-4994-94cd-a769770b4c59", + "image_id": 204950, + "image_name": "13582.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 92.283, + 1134.304, + 1551.53, + 449.82899999999995 + ], + "priority": 4, + "parents": [ + 114517 + ], + "children": [], + "area": 104676.976032, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 114518, + "strid": "e472a99e-f647-4bcd-aa8c-a39d1cd9de49", + "image_id": 204950, + "image_name": "13582.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 132.838, + 1606.817, + 437.35300000000007, + 60.815000000000055 + ], + "priority": 5, + "parents": [ + 114558 + ], + "children": [ + 114536 + ], + "area": 213446.356646, + "iscrowd": 0, + "segmentation": [], + "text": "Study Questions:" + }, + { + "id": 114536, + "strid": "2b8bf1b6-1d3a-405c-8186-2ca4b88c5e55", + "image_id": 204950, + "image_name": "13582.png", + "category_id": 4, + 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"image_name": "13582.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 149.971, + 3178.233, + 1332.082, + 193.80299999999988 + ], + "priority": 16, + "parents": [ + 114519 + ], + "children": [], + "area": 476642.78124300006, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 114523, + "strid": "4e92fafc-4751-469b-ae4e-d0bad4cf4fc2", + "image_id": 204950, + "image_name": "13582.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 100.206, + 3485.075, + 263.25, + 39.80000000000018 + ], + "priority": 17, + "parents": [ + 114558 + ], + "children": [ + 114531, + 114540, + 114532 + ], + "area": 349225.42545, + "iscrowd": 0, + "segmentation": [], + "text": "Quality of PU:" + }, + { + "id": 114540, + "strid": "d6eeea19-fea7-4b14-ba70-85f1b1955fdc", + "image_id": 204950, + "image_name": "13582.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 92.496, + 3766.688, + 489.375, + 506.808 + ], + "priority": 18, + "parents": [ + 114523 + ], + "children": [], + "area": 348403.573248, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 114531, + "strid": "7ce703b8-adcb-4685-950a-6409bf86fa3f", + "image_id": 204950, + "image_name": "13582.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 680.312, + 3510.931, + 962.7409999999999, + 454.45899999999983 + ], + "priority": 19, + "parents": [ + 114523 + ], + "children": [ + 114553 + ], + "area": 2388528.490472, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 114553, + "strid": "8b655660-1617-4b93-b66c-cd588a77ac14", + "image_id": 204950, + "image_name": "13582.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 680.695, + 3945.905, + 375.6920000000001, + 19.001999999999953 + ], + "priority": 20, + "parents": [ + 114531 + ], + "children": [], + "area": 2685957.8039750005, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 3a PU quality from PUTS in simple and complex tics" + }, + { + "id": 114532, + "strid": "4f56a258-e04e-46e7-a46b-0243af10d6c6", + "image_id": 204950, + "image_name": "13582.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 658.37, + 3978.455, + 963.545, + 453.0169999999998 + ], + "priority": 21, + "parents": [ + 114523 + ], + "children": [ + 114554 + ], + "area": 2619295.41835, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 114554, + "strid": "3d4d224c-2767-4168-b63d-0e469adcb5b8", + "image_id": 204950, + "image_name": "13582.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 674.453, + 4416.629, + 352.1100000000001, + 18.886000000000422 + ], + "priority": 22, + "parents": [ + 114532 + ], + "children": [], + "area": 2978808.6789369998, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 3b PU quality from PUTS in vocal and motor tics" + }, + { + "id": 114520, + "strid": "14fa096b-26b9-4604-b77a-b44dce223149", + "image_id": 204950, + "image_name": "13582.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1739.401, + 1057.016, + 244.942, + 48.88599999999997 + ], + "priority": 23, + "parents": [ + 114558 + ], + "children": [ + 114547, + 114534, + 114545, + 114527, + 114529, + 114530, + 114544, + 114543, + 114528, + 114526, + 114542 + ], + "area": 1838574.6874160003, + "iscrowd": 0, + "segmentation": [], + "text": "Methods:" + }, + { + "id": 114545, + "strid": "c1f3f57c-cd0f-4336-be60-fd15489fefc2", + "image_id": 204950, + "image_name": "13582.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1732.973, + 1127.18, + 1484.5370000000003, + 195.33400000000006 + ], + "priority": 24, + "parents": [ + 114520 + ], + "children": [], + "area": 1953372.50614, + "iscrowd": 0, + "segmentation": [], + "text": "We constructed an online survey using an online survey platform (SoSciSurvey) to investigate\nthe quality and location of PU based on the methods used by Leckman et al. in 1993. A large\nsample of adult patients (>18y) was recruited from our clinic and over self-help groups and\nassociations." + }, + { + "id": 114544, + "strid": "9bcbeed6-2c97-41bb-9609-0bc9b4168f38", + "image_id": 204950, + "image_name": "13582.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1739.998, + 1388.441, + 1481.2329999999997, + 496.62099999999987 + ], + "priority": 25, + "parents": [ + 114520 + ], + "children": [], + "area": 2415884.563118, + "iscrowd": 0, + "segmentation": [], + "text": "Improvements over Leckman et al.:\n\n1. Detailed recording of all tics via the checklist of the Yale Global Tic Severity Scale\n(YGTSS)\n\n2. Information on the location and quality of PU was collected for each tic individually\nvia adaptive online questionnaire and an integrated body map and items taken\nfrom the Premonitory Urge for Tics scale (PUTS)\n\n3. Larger sample size\nNo limitation in amount of tics described\n\n5. Additional information collected on sensational quality of the PU such as constancy,\nintensity and lateralization" + }, + { + "id": 114543, + "strid": "1438cb1c-a513-41f6-9489-db6b748a3245", + "image_id": 204950, + "image_name": "13582.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1691.113, + 2000.937, + 1518.481, + 236.7779999999998 + ], + "priority": 26, + "parents": [ + 114520 + ], + "children": [], + "area": 3383810.572881, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 114526, + "strid": "55c0ed43-ded6-47e1-9b3f-28d7d970f8c9", + "image_id": 204950, + "image_name": "13582.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1800.313, + 2251.771, + 734.6759999999999, + 592.75 + ], + "priority": 27, + "parents": [ + 114520 + ], + "children": [ + 114546 + ], + "area": 4053892.6043230006, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 114546, + "strid": "b28c6bdd-9b87-461c-b395-e349e81e2b75", + "image_id": 204950, + "image_name": "13582.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1795.91, + 2851.624, + 587.9260000000002, + 39.427000000000135 + ], + "priority": 28, + "parents": [ + 114526 + ], + "children": [], + "area": 5121260.05784, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 4 Comparison of PU accross body areas in Leckman et al. 1993 (left) and our study\n(limited to the 10 most frequent PU, right)" + }, + { + "id": 114547, + "strid": "88ac89a7-c98b-4c4a-bbaf-17a53f4c8eda", + "image_id": 204950, + "image_name": "13582.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1794.17, + 2904.387, + 576.9090000000001, + 33.628999999999905 + ], + "priority": 29, + "parents": [ + 114520 + ], + "children": [], + "area": 5210964.023790001, + "iscrowd": 0, + "segmentation": [], + "text": "Right image taken from: Rickards H Republished review: Tourette's syndrome and other tic disorders\nPostgraduate Medical Journal 2011;87:142-149." + }, + { + "id": 114534, + "strid": "5bf4702a-2c47-459e-b5d3-0b2033b0fba9", + "image_id": 204950, + "image_name": "13582.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2593.085, + 2345.605, + 563.8200000000002, + 414.5169999999998 + ], + "priority": 30, + "parents": [ + 114520 + ], + "children": [ + 114548 + ], + "area": 6082353.1414250005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 114548, + "strid": "77f936a2-2a91-4ac2-b79f-0c00d2e783d0", + "image_id": 204950, + "image_name": "13582.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2598.473, + 2777.753, + 556.7979999999998, + 20.192000000000007 + ], + "priority": 31, + "parents": [ + 114534 + ], + "children": [], + "area": 7217916.171169001, + "iscrowd": 0, + "segmentation": [], + "text": "Table 2 Most frequent body areas identified by Leckman et al. 1993 and our study" + }, + { + "id": 114527, + "strid": "88250c8a-38db-4670-af8a-f1341532ce59", + "image_id": 204950, + "image_name": "13582.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1762.257, + 2968.062, + 723.348, + 392.741 + ], + "priority": 32, + "parents": [ + 114520 + ], + "children": [ + 114552 + ], + "area": 5230488.035934, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 114552, + "strid": "385253b3-144d-490b-a83c-73f9339a3c22", + "image_id": 204950, + "image_name": "13582.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1771.183, + 3375.16, + 328.1080000000002, + 17.735999999999876 + ], + "priority": 33, + "parents": [ + 114527 + ], + "children": [], + "area": 5978026.01428, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 5a Lateralization of tics on both body halves" + }, + { + "id": 114529, + "strid": "77231643-e829-4dc8-8950-fcadee1bfac6", + "image_id": 204950, + "image_name": "13582.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2575.781, + 2968.891, + 696.1860000000001, + 436.8220000000001 + ], + "priority": 34, + "parents": [ + 114520 + ], + "children": [ 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"9e734c2c-2631-4336-ab86-6eb1dc57a589", + "image_id": 204950, + "image_name": "13582.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1762.322, + 3823.773, + 326.80399999999986, + 19.25 + ], + "priority": 37, + "parents": [ + 114528 + ], + "children": [], + "area": 6738719.280906, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 5b Lateralization of PU on both body halves" + }, + { + "id": 114530, + "strid": "c645dc23-dabe-4b7b-8e0a-1e3a41f793a3", + "image_id": 204950, + "image_name": "13582.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2579.206, + 3512.05, + 626.2619999999997, + 265.2399999999998 + ], + "priority": 38, + "parents": [ + 114520 + ], + "children": [ + 114550 + ], + "area": 9058300.432300001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 114550, + "strid": "23ec7f5b-8da5-4cff-9dbe-0de26e1c6220", + "image_id": 204950, + "image_name": "13582.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 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Th\nAAT tna. Tha lemaminete for SY env ebioneemiyets une" + }, + { + "id": 106705, + "strid": "3d4faa68-788d-40b4-b037-2e812363e400", + "image_id": 204630, + "image_name": "12576.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 402.876, + 915.086, + 393.674, + 55.47500000000002 + ], + "priority": 17, + "parents": [ + 106695 + ], + "children": [], + "area": 368666.187336, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 106697, + "strid": "dc380642-78b7-41f4-b5df-b36947dd2243", + "image_id": 204630, + "image_name": "12576.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 558.663, + 994.082, + 83.519, + 13.788999999999987 + ], + "priority": 18, + "parents": [ + 106711 + ], + "children": [ + 106704 + ], + "area": 555356.832366, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 106704, + "strid": "9673b294-a5bc-4450-878b-55765f23d979", + "image_id": 204630, + "image_name": "12576.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 401.877, + 1027.61, + 397.46999999999997, + 114.88300000000004 + ], + "priority": 19, + "parents": [ + 106697 + ], + "children": [], + "area": 412972.82396999997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 84157, + "strid": "66c8f7bb-d075-4940-80bc-c5834dd38ff9", + "image_id": 203769, + "image_name": "120891.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 1777.45, + 368.07, + 354.8100000000002, + 199.57999999999998 + ], + "priority": -1, + "parents": [], + "children": [ + 84151, + 84132, + 84137, + 84144, + 84134, + 84145, + 84149, + 84139, + 84150, + 84143, + 84133, + 84135, + 84136, + 84156, + 84138 + ], + "area": 654226.0215, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 84132, + "strid": "47596449-0b75-409c-ab25-0f8ac788ac9c", + "image_id": 203769, + "image_name": "120891.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 102.094, + 59.171, + 3703.803, + 259.953 + ], + "priority": 1, + "parents": [ + 84157 + ], + "children": [], + "area": 6041.0040739999995, + "iscrowd": 0, + "segmentation": [], + "text": "Composition and diversity of the gut microbiome: comparing the Inuit of\nResolute Bayand residents of Montreal" + }, + { + "id": 84133, + "strid": "aea591f2-0bbf-4bba-9d77-c3ccdb1209da", + "image_id": 203769, + "image_name": "120891.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 107.174, + 358.513, + 1568.42, + 227.97200000000004 + ], + "priority": 2, + "parents": [ + 84157 + ], + "children": [], + "area": 38423.272262, + "iscrowd": 0, + "segmentation": [], + "text": "C. Girard'*, M-Amyot', B. J. Shapiro!\n\n1. Département de sciences biologiques, Université de Montréal, MontréalyCanada\n2. Center for Northern Studies, Université de Montréal, Montréal, Canada\nCorresponding author: catherine.girard.7@umontreal.ca" + }, + { + "id": 84134, + "strid": "0c7da3f0-6ecb-4188-bcff-4f3895dc9692", + "image_id": 203769, + "image_name": "120891.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 651.939, + 649.161, + 175.79100000000005, + 41.40700000000004 + ], + "priority": 3, + "parents": [ + 84157 + ], + "children": [ + 84146 + ], + "area": 423213.37317899993, + "iscrowd": 0, + "segmentation": [], + "text": "Context" + }, + { + "id": 84146, + "strid": "0f0ecbfd-a8df-410b-948a-da1b77223ce8", + "image_id": 203769, + "image_name": "120891.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 123.747, + 728.564, + 1230.869, + 849.9720000000001 + ], + "priority": 4, + "parents": [ + 84134 + ], + "children": [], + "area": 90157.609308, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 84151, + "strid": "407d1c46-27c8-4354-8e7f-86532d0fdb88", + "image_id": 203769, + "image_name": "120891.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 107.476, + 1814.436, + 2034.958, + 1460.764 + ], + "priority": 5, + "parents": [ + 84157 + ], + "children": [ + 84153 + ], + "area": 195008.32353599998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 84153, + "strid": "2cbaaef4-62e8-4661-9c85-e3f00fd9ecff", + "image_id": 203769, + "image_name": "120891.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 122.902, + 1719.539, + 1626.182, + 58.75199999999995 + ], + "priority": 6, + "parents": [ + 84151 + ], + "children": [], + "area": 211334.782178, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. Composition of sampled gut microbiomes at the phylum level" + }, + { + "id": 84143, + "strid": "7913018f-1832-4164-85f9-5fddeb4eeca2", + "image_id": 203769, + "image_name": "120891.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 124.151, + 3338.432, + 1994.7969999999998, + 449.77599999999984 + ], + "priority": 7, + "parents": [ + 84157 + ], + "children": [], + "area": 414469.67123199994, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. Composition at the phylum level varied across individuals. B«Microbial taxonomic richness was\ngreater in samples from Montreal when compared to those from)Resolute Bay, potentially due to the\nmore diversified diet of the Montreal residents. Country food consumers had lower alpha diversity. C.\nProteobacteria were enriched in the Resolute Bay microbiomes, which has recently been observed by\nSchnorr etal (2014) in the microbiomes of the Hadza people‘of Tanzania. D & E. Montreal samples present\nwith a higher relative abundance of Firmicutes, while Bacteroidetes were enriched in the Resolute samples.\nThis*Suggests that participants from Montreal have*a higher Firmicutes:Bacteroidetes ratio (2.4 + 1.0)\nthan the Resolute Bay participants (1.3 + 0.9), which,is consistent with previous comparisons of European\nchildren to Burkinabé children who have a ‘traditional’ diet (De Filippo et al., 2010)." + }, + { + "id": 84135, + "strid": "fc21e0af-84d8-41c5-96ac-64846c3b8158", + "image_id": 203769, + "image_name": "120891.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2024.898, + 642.955, + 287.4979999999998, + 53.226 + ], + "priority": 8, + "parents": [ + 84157 + ], + "children": [ + 84152 + ], + "area": 1301918.2935900001, + "iscrowd": 0, + "segmentation": [], + "text": "Study groups" + }, + { + "id": 84152, + "strid": "605b15f0-b50e-4915-acde-8b2d16627381", + "image_id": 203769, + "image_name": "120891.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1505.869, + 724.538, + 1323.981, + 97.42499999999995 + ], + "priority": 9, + "parents": [ + 84135 + ], + "children": [], + "area": 1091059.3135219999, + "iscrowd": 0, + "segmentation": [], + "text": "Adults from Resolute Bay and (Montreal (n = 14). 3 400 km apart,\ndistinct genetic, cultural and dietary backgrounds" + }, + { + "id": 84136, + "strid": "a3b1f43e-49bf-497d-8f9b-da4b6ea4613e", + "image_id": 203769, + "image_name": "120891.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2076.627, + 896.86, + 194.54700000000003, + 43.500999999999976 + ], + "priority": 10, + "parents": [ + 84157 + ], + "children": [ + 84131, + 84147 + ], + "area": 1862443.69122, + "iscrowd": 0, + "segmentation": [], + "text": "Inuit diet" + }, + { + "id": 84147, + "strid": "c38376a8-4f7b-4fa6-a214-427b1d9db1ff", + "image_id": 203769, + "image_name": "120891.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1508.041, + 977.069, + 1163.2829999999997, + 248.7270000000001 + ], + "priority": 11, + "parents": [ + 84136 + ], + "children": [], + "area": 1473460.1118289998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 84131, + "strid": "f6e4a366-b899-47e4-9c4a-9f97f9ae0182", + "image_id": 203769, + "image_name": "120891.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1495.641, + 1276.838, + 1354.5570000000002, + 322.1020000000001 + ], + "priority": 12, + "parents": [ + 84136 + ], + "children": [], + "area": 1909691.263158, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 84144, + "strid": "ef41f512-0145-4681-bc0c-63be93ab438f", + "image_id": 203769, + "image_name": "120891.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2266.709, + 1719.307, + 576.0639999999999, + 898.7610000000002 + ], + "priority": 13, + "parents": [ + 84157 + ], + "children": [], + "area": 3897168.6506629996, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2. Community\ncomposition visualized using\nprincipal coordinates analysis\n(PCoA) of weighted UniFrac\ndistance matrices shows that\nMontreal microbiomes\ncluster together. Meanwhile\nResolute Bay microbiomés are\ndispersed and /Separated\nfrom the Montreal samples.\nThis suggests, greater inter-\nindividual-variability amongst\nInuit participants. A PCoA of\nunweighted UniFrac distances\nproduced a similar pattern.\n(Note that UniFrac measures\ncommunity similarity based\non shared branch length.)" + }, + { + "id": 84145, + "strid": "a113f096-5737-402e-a1c5-e0230c4fbc50", + "image_id": 203769, + "image_name": "120891.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2267.487, + 2742.801, + 576.4290000000001, + 1039.9720000000002 + ], + "priority": 14, + "parents": [ + 84157 + ], + "children": [], + "area": 6219265.611087, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1. Metadata analysis\nwas done by partitioning a\nmatrix of unweighted\nUniFrac distances among\nsources of variation, in order\nto describe the strength» (R2)\nand significance (P) that a\ncategory has in .détermining\nvariance. Community, age\nand diet significantly explain\na portionCof the variation.\nOrigin of the sample (Resolute\nBay..or )Montreal) as well as\nfrequency of consumption of\ncountry food in particular\nexplained respectively 14.4\nand 26.4% of variation,\nunderscoring the importance\nof diet in driving the\ncomposition of the gut\nmicrobiome." + }, + { + "id": 84156, + "strid": "171688c0-0c4a-4693-b769-d8c53b1899bd", + "image_id": 203769, + "image_name": "120891.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2316.37, + 0.488, + 2013.9160000000002, + 1713.588 + ], + "priority": 15, + "parents": [ + 84157 + ], + "children": [], + "area": 1130.3885599999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 84137, + "strid": "e99038ac-3fff-499f-bf48-7cb034ec8940", + "image_id": 203769, + "image_name": "120891.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3501.441, + 1238.915, + 192.6869999999999, + 43.63799999999992 + ], + "priority": 16, + "parents": [ + 84157 + ], + "children": [ + 84148 + ], + "area": 4337987.776515, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 84148, + "strid": "509c0769-61e1-49e8-9c84-3221249bbaec", + "image_id": 203769, + "image_name": "120891.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2993.093, + 1320.54, + 1215.089, + 275.991 + ], + "priority": 17, + "parents": [ + 84137 + ], + "children": [], + "area": 3952499.0302199996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 84150, + "strid": "f1cf466c-470b-496d-8f6a-7f34e5c4ae65", + "image_id": 203769, + "image_name": "120891.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2957.365, + 1907.702, + 1330.0060000000003, + 736.847 + ], + "priority": 18, + "parents": [ + 84157 + ], + "children": [ + 84154 + ], + "area": 5641771.125229999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 84154, + "strid": "cb9baea5-eb9f-4082-913c-1e9392cd2317", + "image_id": 203769, + "image_name": "120891.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2957.133, + 1718.342, + 1061.228, + 59.03500000000008 + ], + "priority": 19, + "parents": [ + 84150 + ], + "children": [], + "area": 5081365.833486, + "iscrowd": 0, + "segmentation": [], + "text": "Figure’2. Weighted PCoA of UniFrac distances" + }, + { + "id": 84149, + "strid": "38299073-0f08-4f60-953d-7a3e44fd1f9a", + "image_id": 203769, + "image_name": "120891.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2955.604, + 2920.94, + 1281.8889999999997, + 872.8890000000001 + ], + "priority": 20, + "parents": [ + 84157 + ], + "children": [ + 84155 + ], + "area": 8633141.947759999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 84155, + "strid": "a0d88124-b655-49e4-b0ef-6c67b0e642a5", + "image_id": 203769, + "image_name": "120891.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2950.391, + 2743.943, + 1194.8380000000002, + 105.33800000000019 + ], + "priority": 21, + "parents": [ + 84149 + ], + "children": [], + "area": 8095704.731713001, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1. Analysis of variance using UniFrac distances\nand metadata" + }, + { + "id": 84138, + "strid": "f876bf94-0cd8-4cb0-8b58-bdd1ff823c1d", + "image_id": 203769, + "image_name": "120891.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1347.649, + 3897.572, + 264.13699999999994, + 43.315000000000055 + ], + "priority": 22, + "parents": [ + 84157 + ], + "children": [ + 84142, + 84141 + ], + "area": 5252559.008227999, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 84141, + "strid": "adf0378c-f9f7-49fe-826b-57522929a2f1", + "image_id": 203769, + "image_name": "120891.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 130.881, + 3955.052, + 1350.079, + 303.24500000000035 + ], + "priority": 23, + "parents": [ + 84138 + ], + "children": [], + "area": 517641.16081200005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 84142, + "strid": "72099394-3489-4e28-855b-077294e21b22", + "image_id": 203769, + "image_name": "120891.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1515.77, + 3956.517, + 1316.665, + 299.5020000000004 + ], + "priority": 24, + "parents": [ + 84138 + ], + "children": [], + "area": 5997169.773089999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 84139, + "strid": "8c44a995-0dc7-4f0b-8742-38f101c2cec3", + "image_id": 203769, + "image_name": "120891.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3228.63, + 3890.575, + 743.3679999999999, + 59.427999999999884 + ], + "priority": 25, + "parents": [ + 84157 + ], + "children": [ + 84140 + ], + "area": 12561227.16225, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgments andreferences" + }, + { + "id": 84140, + "strid": "ebb7f205-e43c-4c92-ab18-0d9d2f15105a", + "image_id": 203769, + "image_name": "120891.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2987.768, + 3954.214, + 1226.2910000000002, + 298.3850000000002 + ], + "priority": 26, + "parents": [ + 84139 + ], + "children": [], + "area": 11814274.054352, + "iscrowd": 0, + "segmentation": [], + "text": "Special thanks to Lawrence Davidand Peter Turnbaugh for the\nDNA extraction protocol, and,‘to Sarah P. Preheim, Allison\nPerrotta and Caroline Antolik-for the 16S library preparation\nprotocol.\n\nDe Filippo et al.,(2010) PNAS, 107(33):14691-14696. /Yatsunenko et al., (2012) Nature, 486:222-228. / Schnorr et al., (2014) Nature\n\n5:3654. / Turnbaugh et al., (2009) Sci. Transl. Med. 1(6):1-19. / Delzenne and Cani, (2011) Annu. Rev. Nutr. 31:15-31. / Di Rienzi et\nal., (2013) eLife 2:1-25. / Caporaso et al.(2011),Gen. Bio. 12:R50." + }, + { + "id": 177578, + "strid": "ca2666dc-e77a-4e1e-8a3d-07e14449eba0", + "image_id": 207431, + "image_name": "8096.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 90.29, + 46.92, + 388.88, + 241.37 + ], + "priority": -1, + "parents": [], + "children": [ + 177563, + 177575, + 177573, + 177576, + 177562, + 177561, + 177571, + 177572, + 177574 + ], + "area": 4236.406800000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 177561, + "strid": "72ed1096-e8d0-454c-9f25-1e159773a015", + "image_id": 207431, + "image_name": "8096.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 604.851, + 266.307, + 2395.931, + 242.86199999999997 + ], + "priority": 1, + "parents": [ + 177578 + ], + "children": [], + "area": 161076.055257, + "iscrowd": 0, + "segmentation": [], + "text": "RARE CASE OF PRIMARY MEDIASTINAL NSGCT\nIN A YOUNG FEMALE" + }, + { + "id": 177562, + "strid": "05f0e7d8-1674-475f-9213-bcc44a083257", + "image_id": 207431, + "image_name": "8096.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 596.26, + 551.503, + 2411.6179999999995, + 146.159 + ], + "priority": 2, + "parents": [ + 177578 + ], + "children": [], + "area": 328839.17878, + "iscrowd": 0, + "segmentation": [], + "text": "Dr. Manikandan D, Dr. Venkatraman R, Dr. Sagar T G, Dr. Rejiv R, Dr. Prashanth G, Dr. Shirley S\nDepartment of Medical Oncology, Cancer Institute (WIA), Chennai" + }, + { + "id": 177573, + "strid": "abb106a1-a27c-4505-bd78-3ff09d080d1f", + "image_id": 207431, + "image_name": "8096.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 116.552, + 762.079, + 666.295, + 233.95399999999995 + ], + "priority": 3, + "parents": [ + 177578 + ], + "children": [], + "area": 88821.831608, + "iscrowd": 0, + "segmentation": [], + "text": "15/F\n\nBreathlessness since 1 month\nO/E—No PLNE, No HSM,\nDecreased BS in right hemithorax" + }, + { + "id": 177575, + "strid": "02464cb6-21ff-41d7-95cf-75767761a031", + "image_id": 207431, + "image_name": "8096.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 112.797, + 1070.706, + 1537.166, + 1397.137 + ], + "priority": 4, + "parents": [ + 177578 + ], + "children": [], + "area": 120772.42468199998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 177574, + "strid": "db67faaa-0663-4910-9c53-dd37b8730a25", + "image_id": 207431, + "image_name": "8096.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 116.409, + 2597.127, + 1538.408, + 225.20199999999977 + ], + "priority": 5, + "parents": [ + 177578 + ], + "children": [], + "area": 302328.956943, + "iscrowd": 0, + "segmentation": [], + "text": "PET CT — 16 * 11 * 10 cm large multicystic mass with enhancing septa and\ncalcifications in right paracardiac region and mid and lower zone of right\nhemithorax with SUV 2.8\n\nUterus & Bilateral adnexa—N" + }, + { + "id": 177576, + "strid": "f0b528cb-69f6-4062-aa75-e89172119a02", + "image_id": 207431, + "image_name": "8096.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 112.904, + 2891.681, + 1537.879, + 1494.0880000000002 + ], + "priority": 6, + "parents": [ + 177578 + ], + "children": [ + 177577 + ], + "area": 326482.351624, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 177577, + "strid": "030235d8-8a00-40f2-ab40-3f8af47d3619", + "image_id": 207431, + "image_name": "8096.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 114.327, + 4479.619, + 1542.099, + 169.02400000000034 + ], + "priority": 7, + "parents": [ + 177576 + ], + "children": [], + "area": 512141.40141299996, + "iscrowd": 0, + "segmentation": [], + "text": "CT Guided Bx — Cystic structures lined by keratinised squamous epithelium,\nmucinous glands, ganglion cells, smooth muscle bundles, Suggestive of\nTeratoma." + }, + { + "id": 177572, + "strid": "1a2206ab-045a-4bf3-a2b0-3dcbf0493d3a", + "image_id": 207431, + "image_name": "8096.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1944.211, + 763.691, + 468.3080000000002, + 51.40999999999997 + ], + "priority": 8, + "parents": [ + 177578 + ], + "children": [], + "area": 1484776.442801, + "iscrowd": 0, + "segmentation": [], + "text": "Bone marrow study — N" + }, + { + "id": 177571, + "strid": "31c3f9e6-3bb2-496d-8666-da736ee69939", + "image_id": 207431, + "image_name": "8096.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1942.812, + 882.505, + 1233.971, + 470.188 + ], + "priority": 9, + "parents": [ + 177578 + ], + "children": [], + "area": 1714541.30406, + "iscrowd": 0, + "segmentation": [], + "text": "Diagnosis\nPrimary mediastinal NSGCT, Poor Risk, S 1 Marker\n\nAfter EP 1° Cycle and BEP 2™ cycle\nAFP — 17 ; HCG — Normal ; LDH — Normal\n\nBut CT Chest — Static Response\nShe is planned for BEP # 4 cycles and reassessment for surgery" + }, + { + "id": 177563, + "strid": "d4c53cb7-9e6f-4011-8cb7-d4b0ccfeb943", + "image_id": 207431, + "image_name": "8096.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1939.666, + 1427.974, + 602.4170000000001, + 67.05300000000011 + ], + "priority": 10, + "parents": [ + 177578 + ], + "children": [ + 177569, + 177564, + 177567, + 177566, + 177570, + 177568 + ], + "area": 2769792.616684, + "iscrowd": 0, + "segmentation": [], + "text": "LITERATURE REVIEW" + }, + { + "id": 177564, + "strid": "f36bb6dd-1cb4-45cc-a407-789062b2a2a8", + "image_id": 207431, + "image_name": "8096.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1936.765, + 1526.886, + 1543.416, + 632.2660000000001 + ], + "priority": 11, + "parents": [ + 177563 + ], + "children": [], + "area": 2957219.36379, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 177567, + "strid": "2ddd9e0d-cb79-4d02-93d0-28779e25aa57", + "image_id": 207431, + "image_name": "8096.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1943.771, + 2198.218, + 243.27800000000002, + 64.08300000000008 + ], + "priority": 12, + "parents": [ + 177563 + ], + "children": [], + "area": 4272832.400078, + "iscrowd": 0, + "segmentation": [], + "text": "Prognosis’" + }, + { + "id": 177566, + "strid": "f5c65ed9-857e-460a-8af4-de99b56a7b0c", + "image_id": 207431, + "image_name": "8096.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2250.812, + 2291.34, + 901.221, + 696.8760000000002 + ], + "priority": 13, + "parents": [ + 177563 + ], + "children": [ + 177565 + ], + "area": 5157375.56808, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 177565, + "strid": "55c00d38-c0d2-4cea-add0-f03570227cf6", + "image_id": 207431, + "image_name": "8096.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2357.0, + 2816.146, + 671.319, + 133.89300000000003 + ], + "priority": 14, + "parents": [ + 177566 + ], + "children": [], + "area": 6637656.122, + "iscrowd": 0, + "segmentation": [], + "text": "FIGURE 1. Survival of 95 patients with mature teratomas, 13 patients with\nseminomas, and 21 patients with nonseminomatous germ cell tumors (NSGCT)\nincluding disease-related and disease-unrelated deaths. Thin line: teratoma;\ndotted line: semonoma; thick line: NSGCT." + }, + { + "id": 177568, + "strid": "8f52160c-f4f4-48ac-84c7-4c084ca8eeaf", + "image_id": 207431, + "image_name": "8096.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1940.019, + 3035.414, + 1531.512, + 626.5529999999999 + ], + "priority": 15, + "parents": [ + 177563 + ], + "children": [], + "area": 5888760.832866, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 177569, + "strid": "e554d65e-d52a-4c61-a3a9-986d3e3dbf32", + "image_id": 207431, + "image_name": "8096.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1940.472, + 3731.771, + 1455.8060000000003, + 313.89300000000003 + ], + "priority": 16, + "parents": [ + 177563 + ], + "children": [], + "area": 7241397.135912, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 177570, + "strid": "6250ec1f-3f1d-47f0-9bad-5f8241a26ed3", + "image_id": 207431, + "image_name": "8096.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1940.844, + 4099.305, + 1580.73, + 572.1009999999997 + ], + "priority": 17, + "parents": [ + 177563 + ], + "children": [], + "area": 7956111.513420001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 62089, + "strid": "8b841bb8-0a23-459c-9db1-a5fc9ffc5d01", + "image_id": 202947, + "image_name": "119489.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 72.02, + 44.25, + 88.61999999999999, + 86.74000000000001 + ], + "priority": -1, + "parents": [], + "children": [ + 62075, + 62073, + 62074, + 62070, + 62072, + 62071, + 62069 + ], + "area": 3186.8849999999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 62069, + "strid": "8d24e6d7-ef1c-4cf4-a451-c47f0002476c", + "image_id": 202947, + "image_name": "119489.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 184.299, + 29.307, + 830.116, + 28.498 + ], + "priority": 1, + "parents": [ + 62089 + ], + "children": [], + "area": 5401.250793, + "iscrowd": 0, + "segmentation": [], + "text": "Intensity Sensitivity and,tmpulsivity in Antisocial Personality Disorder" + }, + { + "id": 62070, + "strid": "5b07e61d-1924-459f-a472-7227fa8dacbc", + "image_id": 202947, + "image_name": "119489.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 259.943, + 73.301, + 681.585, + 76.82600000000001 + ], + "priority": 2, + "parents": [ + 62089 + ], + "children": [], + "area": 19054.081843, + "iscrowd": 0, + "segmentation": [], + "text": "Marijn Lijffijt', Alan C. Swann'*\n\n' Menninger Department of Psychiatry and Behavioral Sciences}Bayior College of Medicine, Houston, TX, USA\n2 Michael E. DeBakey VA MedicdhCenter, Houston." + }, + { + "id": 62071, + "strid": "13802a3e-1c05-4b77-a5d3-c297550dab47", + "image_id": 202947, + "image_name": "119489.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 144.466, + 185.123, + 86.239, + 10.90100000000001 + ], + "priority": 3, + "parents": [ + 62089 + ], + "children": [ + 62076 + ], + "area": 26743.979318, + "iscrowd": 0, + "segmentation": [], + "text": "1. Introduction" + }, + { + "id": 62076, + "strid": "59a18687-9162-4a3b-9629-03adc5b608fd", + "image_id": 202947, + "image_name": "119489.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 17.708, + 208.574, + 342.49700000000007, + 502.906 + ], + "priority": 4, + "parents": [ + 62071 + ], + "children": [], + "area": 3693.428392, + "iscrowd": 0, + "segmentation": [], + "text": "ANtSCay Seneviors and antisocie personality Clege SPO)\nhave)been related to (a) increased trait impulsivity) impulsive\naction (poor response inhibition), and impulsive thoice (more\ndelay discounting) (Swann et al, 2008); and (bKenhanced early-\nattentional processing of irrelevant stimuli (Houston and Stanford,\n2001), and diminished pre-attentional senSof¥ gating (Lift etal.\n2012). These outcomes suggest impaired early orienting to\nirrelevant information in people with sitisocial behaviors or ASPD\nwiich may relate to increased impulsivity\n\nStimulus orienting can be tepsured as changes in Pt, Ni, or P2\nevoked potential amplitides to increased stimulus intensity\n(Buchsbaum and Silverman, 1986). P1 (or P50) could reflect pre-\nattentional stimulus processing (Naatanen, 1992), N1 could reflect\ncarly triggering éPtention (N88tnen, 1982; Rinne et al, 2006),\nand P2 could elect early allocation of attention and intial\nconscious \\avlareness (Naatanen, 1992). More pronoyned\nincreas&@in amplitudes with more intense stimuli may Yeflect\nincfeased stimulus orientation.\n\niAthealthy controls amplitude increases are less ffoniounced or\neven blunted at the highest intensities, whereat people with\nimpulsive aggression (Houston and Stanford) 2001) or with high\ntrait impulsivity or hypomania symptom@\\(Barratt et al., 1987;\nCarrilo-de-la-Pefia and Barratt, 1993;-Hénich et al, 2007; Lifit et\nal, submitted; Norra et a, 2003) showed a continued increase in\namplitudes. This suggests increded orienting to more intense\nstimuli with increased traft~iinpulsivity which might trigger\nimpulsive actions.\n\nWe explored stimulus rienting in ASPD. We expect ASPD to\nhave steeper inténsity-amplitude slopes than controls, and\npeople with ASPO with high trait impulsivity or more symptoms\nto have steepér intensity-amplitude slopes than those with low\nimpulsivity-oefewer symptoms." + }, + { + "id": 62075, + "strid": "3f591a0c-d695-407a-8ac9-263c1842665b", + "image_id": 202947, + "image_name": "119489.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 163.835, + 733.496, + 47.037000000000006, + 8.878000000000043 + ], + "priority": 5, + "parents": [ + 62089 + ], + "children": [ + 62077 + ], + "area": 120172.31716, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 62077, + "strid": "33c9b546-ce52-4f0c-be0d-af735991496b", + "image_id": 202947, + "image_name": "119489.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 20.872, + 744.447, + 336.361, + 444.32900000000006 + ], + "priority": 6, + "parents": [ + 62075 + ], + "children": [], + "area": 15538.097784, + "iscrowd": 0, + "segmentation": [], + "text": "ind study materials were approved by the local IRB. Thirlagest men with\n(Fits eta, 1995, 2997) age 32.4 years; education 122 yes 23 smoking)\ned 18 heathy contol men (age 31.5 years t-04] 9 years (38,\n001], 6 smoking x =38, p05] were recruited rom fhe gPneal population.\n\n \n\n \n\nort a ae oe\n(2) Sbjct cold hae Nore of ageguG aD, sleha e oret\nat dog se dere rat sue ate Fea nary wth se\nrss. ones ha 0 mse ou sl mrt\nsree ees) sujet wih sage se ore sary we ast\narth remit, essed pe eacne meeaton. Cova met\nSitar Wen nto dee te havo Reon mycoses\nedcaton ato 3 at» AGH ot apes i choad o fleece\nhada et Oe\n\nnseesced wer (0 2 2 evoked potentials rom Cz (01-30 He band pass\nTiter; Inked-masoig. ference) wie subjects passively Istened to randomly\npresented 50-295 tis (100 presentations each, 1000 NZ, 0 ms; S12 or 1.2);\n() Wat impullMy: Barat mpusieness Sele, BAI, that asseses 1\n\nimpuliy aa, 3Flated constucts: motor, nom planning, atentionl np\n(Pato 295); (2) impulsive acon: immediate Memory Task IMD\nsubject ast respond to a repetition af a Sgt number; assessed\n\n(hts dad reaction time), eesponse inhibition (commission etfor to\nher crac or ea cet, acon gE Soe\n\nnia (0), nd responses (et) [our et 3 0) imple\nchoke, Two-choeimpustaty Pas Fl ae\n\nete\nTor ar 3 aera ae is eaeg be perenageoed\nots sod naar feces ae vm Pt\n\n \n \n\n \n \n \n \n \n\n \n\nould ean small\n\nSKIP, 2 tre-operant askin whith subjects ca ten as prefered, but\nlonger delays gve move points; assessed were dhyest and longest delay between\nresponses (Dougherty et al, 2003)\n\n \n\nsup teres wer cme tA ns ed (ao\nSte aa see Perit we tes ay\niro sw tr ial senna el Sea 73)\nScenes are fog Copal ere nel wien pte\nCe ee ER at again ae “ome\nsnr fone anita te ero nr fu sua ces\nreli belpeiaihy- ~apepeereieh" + }, + { + "id": 62072, + "strid": "b14091cb-a0e0-4c0e-987c-8b90a99cad3f", + "image_id": 202947, + "image_name": "119489.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 571.894, + 185.15, + 55.70600000000002, + 10.72399999999999 + ], + "priority": 7, + "parents": [ + 62089 + ], + "children": [ + 62086, + 62080, + 62085, + 62084, + 62087 + ], + "area": 105886.1741, + "iscrowd": 0, + "segmentation": [], + "text": "3. Results" + }, + { + "id": 62086, + "strid": "5d4c2a65-5d23-459b-abb7-403f96ba6399", + "image_id": 202947, + "image_name": "119489.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 421.346, + 238.827, + 360.029, + 221.55600000000004 + ], + "priority": 8, + "parents": [ + 62072 + ], + "children": [ + 62083 + ], + "area": 100628.801142, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 62083, + "strid": "7cecd486-ef1d-42cd-a739-5a07ceb7b1cc", + "image_id": 202947, + "image_name": "119489.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 490.133, + 217.151, + 219.86099999999993, + 12.88300000000001 + ], + "priority": 9, + "parents": [ + 62086 + ], + "children": [], + "area": 106432.871083, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 1: Intensity-Amplitudes across Groups" + }, + { + "id": 62085, + "strid": "b4a303fe-77f5-4016-8729-4ed9cdae865d", + "image_id": 202947, + "image_name": "119489.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 404.63, + 505.906, + 402.168, + 100.16299999999995 + ], + "priority": 10, + "parents": [ + 62072 + ], + "children": [ + 62082 + ], + "area": 204704.74478, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 62082, + "strid": "82b04ca7-a5fb-473e-946f-dff8c9eba1de", + "image_id": 202947, + "image_name": "119489.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 481.685, + 482.823, + 235.56900000000002, + 13.856999999999971 + ], + "priority": 11, + "parents": [ + 62085 + ], + "children": [], + "area": 232568.59675499998, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 2: P1, N1, and P2 Slopes for ASPD and NC" + }, + { + "id": 62087, + "strid": "f7eb5920-5c3b-45a3-b329-6e389c5930aa", + "image_id": 202947, + "image_name": "119489.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 390.34, + 615.776, + 418.785, + 260.25 + ], + "priority": 12, + "parents": [ + 62072 + ], + "children": [], + "area": 240362.00383999996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 62084, + "strid": "f2cd4aa6-dc29-4642-aa8a-f3babebaca3e", + "image_id": 202947, + "image_name": "119489.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 400.747, + 937.763, + 400.40899999999993, + 242.46699999999998 + ], + "priority": 13, + "parents": [ + 62072 + ], + "children": [ + 62081 + ], + "area": 375805.708961, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 62081, + "strid": "88d2b1c3-a25f-45af-b2c3-ef15121b303d", + "image_id": 202947, + "image_name": "119489.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 423.701, + 891.834, + 351.99, + 27.936000000000035 + ], + "priority": 14, + "parents": [ + 62084 + ], + "children": [], + "area": 377870.957634, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 5: Correlations between impulsivity Mes¢iiyhs and ®2 intensity-\n‘Amplitude Slopes for ASPD." + }, + { + "id": 62080, + "strid": "102b987c-ffe4-42ec-aa1c-658c064e72d0", + "image_id": 202947, + "image_name": "119489.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 846.279, + 184.051, + 333.943, + 293.407 + ], + "priority": 15, + "parents": [ + 62072 + ], + "children": [], + "area": 155758.49622899998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 62073, + "strid": "8fc5ad99-6bae-4568-b1cc-ab30d3dbdda1", + "image_id": 202947, + "image_name": "119489.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 975.117, + 500.668, + 73.74299999999994, + 11.475999999999999 + ], + "priority": 16, + "parents": [ + 62089 + ], + "children": [ + 62079 + ], + "area": 488209.878156, + "iscrowd": 0, + "segmentation": [], + "text": "4. Discussion" + }, + { + "id": 62079, + "strid": "4df21979-818b-48ac-9db5-e5709b50db21", + "image_id": 202947, + "image_name": "119489.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 846.295, + 516.052, + 335.14099999999996, + 358.159 + ], + "priority": 17, + "parents": [ + 62073 + ], + "children": [], + "area": 436732.22734, + "iscrowd": 0, + "segmentation": [], + "text": "In contrast to our expectations, intapsify sensitivity for auditory\ninformation did not differ betweeA rien with ASPD and healthy\ncontrols. Intensity sensitivitySaid also not relate to trait\nimpulsivity or number of ASPD-symptoms.\n\nRelationships between’P2 intensity sensitivity and measures of\nimpulsive action JM CE/hits) in men with ASPD suggests\nincreased sensithit) to intense stimuli of evoked potentials\nreflecting origriting of attention and early conscious awareness\nof information related to more commission errors ‘ahd\ndiminished signal-noise discriminability. This implies incré@ed\nattentigp to intense stimuli that subsequently enter awareness\ncould fesult in impulsive actions in men with ASPD.\n\nAithough there was also a relationship between 2 slope and\nmeasures of impulsive choice (SKIP), Fig. G>{Bottom panel}\nsuggests this may only be for people with ASPO who are able to\ndelay responding, which seems to be un¢ommon in this group.\n\nAlthough not significant, in copfeols it appears increased\nsensitivity to more intense stimul af evoked potentials reflecting\ntriggering of attention towards-a stimulus (P1N1 slope) may\nrelate to less commistigh “errors and better signal-noise\ndiscrimination. This iqtplie? less impulsive actions with better\ntriggering of attention ¥o more intense stimuli in controls." + }, + { + "id": 62074, + "strid": "d1adf48f-9b8d-4b6c-a1c2-959f8f223094", + "image_id": 202947, + "image_name": "119489.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 977.261, + 892.124, + 69.91399999999999, + 9.373000000000047 + ], + "priority": 18, + "parents": [ + 62089 + ], + "children": [ + 62078, + 62088 + ], + "area": 871837.992364, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 62078, + "strid": "c4511fcc-bed5-49d7-9558-a2de755808e7", + "image_id": 202947, + "image_name": "119489.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 845.825, + 903.806, + 332.519, + 62.20600000000002 + ], + "priority": 19, + "parents": [ + 62074 + ], + "children": [], + "area": 764461.70995, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 62088, + "strid": "71639cc0-d487-4b13-a53a-b7538e4d96f4", + "image_id": 202947, + "image_name": "119489.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 846.175, + 973.626, + 329.00400000000013, + 220.47599999999989 + ], + "priority": 20, + "parents": [ + 62074 + ], + "children": [], + "area": 823857.98055, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 140006, + "strid": "7dfa425a-5d62-4868-a27c-1a5232e50d1e", + "image_id": 205941, + "image_name": "16790.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 208.38, + 163.44, + 148.35000000000002, + 132.23000000000002 + ], + "priority": -1, + "parents": [], + "children": [ + 139971, + 139977, + 139973, + 139986, + 139979, + 139976, + 139975, + 139972, + 139974, + 139978 + ], + "area": 34057.627199999995, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 139971, + "strid": "0ecba05d-cb64-4a3e-9044-a0990cc99a6d", + "image_id": 205941, + "image_name": "16790.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 486.152, + 47.586, + 2301.199, + 157.56899999999996 + ], + "priority": 1, + "parents": [ + 140006 + ], + "children": [], + "area": 23134.029071999998, + "iscrowd": 0, + "segmentation": [], + "text": "iJump: a fast tool for tracking bacterial mobile elements rearrangements\nin course of adaptive laboratory evolution" + }, + { + "id": 139972, + "strid": "66b66e21-8812-4316-9739-1b4192b5603b", + "image_id": 205941, + "image_name": "16790.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1022.954, + 213.172, + 1223.2970000000003, + 96.299 + ], + "priority": 2, + "parents": [ + 140006 + ], + "children": [], + "area": 218065.150088, + "iscrowd": 0, + "segmentation": [], + "text": "Semen A. Leyn\nSanford-Burnham-Prebys Medical Discovery Institute, La Jolla, CA, USA" + }, + { + "id": 139973, + "strid": "894b9de7-fd8c-4a6d-bff9-860c8dd3d981", + "image_id": 205941, + "image_name": "16790.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 61.365, + 413.173, + 337.497, + 59.47500000000002 + ], + "priority": 3, + "parents": [ + 140006 + ], + "children": [ + 139980 + ], + "area": 25354.361145000003, + "iscrowd": 0, + "segmentation": [], + "text": "Motivation" + }, + { + "id": 139980, + "strid": "2f7d0c6f-d9d0-4a6b-95b9-9281e0e1fef2", + "image_id": 205941, + "image_name": "16790.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 56.084, + 505.164, + 779.2719999999999, + 478.0899999999999 + ], + "priority": 4, + "parents": [ + 139973 + ], + "children": [], + "area": 28331.617776, + "iscrowd": 0, + "segmentation": [], + "text": "Genetic changes in bacterial populations\nduring experimenta levolution could be tracked\nby deep sequencing of evolved communities.\n\nThe mobile elements rearrangements are\nfrequently observed during the adaptive experi-\nmental evolution.\n\nIt is extremely helpful to be able to observe\nnot only SNPs and short InDels but also other\nlarge rearrangements. Currently very few soft-\nware tools exists that can work with data of\nmixed populations, not the clonal ones." + }, + { + "id": 139975, + "strid": "7162b7b5-22c4-4147-8a8b-ed5a9ee77e0b", + "image_id": 205941, + "image_name": "16790.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 63.199, + 1021.033, + 239.938, + 58.27100000000007 + ], + "priority": 5, + "parents": [ + 140006 + ], + "children": [ + 139982, + 139981, + 139983 + ], + "area": 64528.264567, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 139981, + "strid": "9be740b3-a5f6-4be8-805c-fba37c879add", + "image_id": 205941, + "image_name": "16790.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 60.514, + 1110.486, + 607.715, + 85.61500000000001 + ], + "priority": 6, + "parents": [ + 139975 + ], + "children": [], + "area": 67199.949804, + "iscrowd": 0, + "segmentation": [], + "text": "Use soft clipped reads\nto find IS elements rearrangements" + }, + { + "id": 139982, + 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~~\n\nBy}.\n14+ min\nRi +R + R, Lav read\n“2*D, D. 1 Mmatcn\nav_read\n\nEstimation of insertion frequency\n\ncorrection for reads underrepresented\ndue to inability to map short fragments\n\nR, - number of reads that support junction to the target\non the \"left\" side of mobile element\n\nR, - number of reads that support junction to the target\non the \"right\" side of mobile element\n\nD, - average depth of caverage of target region\n\nBin ~ Minimum length for unaligned parts that were used\nin the BLAST step\n\nLy pag 2VErage read length\n\nMater ~ Minimum length of the read part that could be\naligned to reference. Accessed as the minimum of lon-\ngest clipped part of the read (e.g. for read with CIGAR\nstring 10S120M30S mmatch is 30)." + }, + { + "id": 139977, + "strid": "746162ca-00d7-4ced-8af6-2fe2f29e967e", + "image_id": 205941, + "image_name": "16790.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 923.944, + 1700.699, + 489.1300000000001, + 65.50299999999993 + ], + "priority": 24, + "parents": [ + 140006 + ], + "children": [ + 139999, + 139997, + 139998 + ], + "area": 1571350.636856, + "iscrowd": 0, + "segmentation": [], + "text": "Simulation test" + }, + { + "id": 139997, + "strid": "b61f1bcb-6e3d-4385-b156-5c38e539e836", + "image_id": 205941, + "image_name": "16790.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 901.884, + 1776.065, + 1062.757, + 306.2370000000001 + ], + "priority": 25, + "parents": [ + 139977 + ], + "children": [], + "area": 1601804.6064600002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 139998, + "strid": "664f402a-c066-48d3-b60d-accbc0a97748", + "image_id": 205941, + "image_name": "16790.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 893.236, + 2083.93, + 1029.641, + 90.61499999999978 + ], + "priority": 26, + "parents": [ + 139977 + ], + "children": [], + "area": 1861441.2974799997, + "iscrowd": 0, + "segmentation": [], + "text": "iJump tends to underestimate frequency. This is happening because iJump summarizes all\nsites along the genetic element (gene or intergenic region) where junctions were found and\nassess frequency with average depth across the entire genetic element." + }, + { + "id": 139999, + "strid": "f6bb4497-c2ec-4e10-a736-c349d0ef00f9", + "image_id": 205941, + "image_name": "16790.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 896.49, + 2204.891, + 855.567, + 30.255999999999858 + ], + "priority": 27, + "parents": [ + 139977 + ], + "children": [], + "area": 1976662.7325900001, + "iscrowd": 0, + "segmentation": [], + "text": "Runtime: BWA MEM (14 threads):20min16sec; iJump (1 thread): 47sec" + }, + { + "id": 139978, + "strid": "e783d067-1bbc-456e-a049-0b8637903b0b", + "image_id": 205941, + "image_name": "16790.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2025.866, + 414.259, + 368.87699999999995, + 70.88999999999999 + ], + "priority": 28, + "parents": [ + 140006 + ], + "children": [ + 140000, + 140004, + 140003, + 140002, + 140001 + ], + "area": 839233.223294, + "iscrowd": 0, + "segmentation": [], + "text": "Experiment" + }, + { + "id": 140000, + "strid": "2259ebe5-a5a9-4137-81f6-e2c706dd32f2", + "image_id": 205941, + "image_name": "16790.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2025.499, + 508.035, + 677.4350000000002, + 37.48999999999995 + ], + "priority": 29, + "parents": [ + 139978 + ], + "children": [], + "area": 1029024.384465, + "iscrowd": 0, + "segmentation": [], + "text": "Adaptive experimental evolution workflow" + }, + { + "id": 140001, + "strid": "21b496c3-a284-4a4f-8540-2237b226f215", + "image_id": 205941, + "image_name": "16790.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2026.541, + 547.231, + 1240.6139999999998, + 379.419 + ], + "priority": 30, + "parents": [ + 139978 + ], + "children": [], + "area": 1108986.057971, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 140002, + "strid": "5b636583-0fa7-41f6-8ce9-76e5446bdf98", + "image_id": 205941, + "image_name": "16790.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2033.004, + 927.017, + 688.6889999999999, + 37.53099999999995 + ], + "priority": 31, + "parents": [ + 139978 + ], + "children": [], + "area": 1884629.269068, + "iscrowd": 0, + "segmentation": [], + "text": "IS elements insertions frequency dynamics" + }, + { + "id": 140003, + "strid": "3cd19a54-c700-4e34-b314-0b50c982aed5", + "image_id": 205941, + "image_name": "16790.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2042.566, + 976.707, + 1241.7880000000002, + 856.3859999999999 + ], + "priority": 32, + "parents": [ + 139978 + ], + "children": [], + "area": 1994988.510162, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 140004, + "strid": "44569f73-846b-453c-ab6e-499ca042d02f", + "image_id": 205941, + "image_name": "16790.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2068.646, + 1836.935, + 1147.3269999999998, + 195.567 + ], + "priority": 33, + "parents": [ + 139978 + ], + "children": [], + "area": 3799968.2400100003, + "iscrowd": 0, + "segmentation": [], + "text": "IS element insertions that should cause overexpression of efflux transporters are\ncommon at the late stages of evolution in E.coli and A.baumannii, which is consis-\ntent to other reports, but not in P. aeruginosa.\n\nInactivation of genes related to pilus and fimbriae biosynthesis was observed in all\nthree organisms. However it could be an adaptation to the culturing environment." + }, + { + "id": 139979, + "strid": "97d1679a-9dd6-4000-b3af-b3ff22233a0d", + "image_id": 205941, + "image_name": "16790.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2026.398, + 2045.78, + 633.3059999999998, + 67.67899999999986 + ], + "priority": 34, + "parents": [ + 140006 + ], + "children": [ + 140005 + ], + "area": 4145564.5004399996, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements" + }, + { + "id": 140005, + "strid": "5d4d7442-42a4-4768-87b5-e03c6a880dc7", + "image_id": 205941, + "image_name": "16790.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2030.543, + 2113.841, + 1198.418, + 161.2750000000001 + ], + "priority": 35, + "parents": [ + 139979 + ], + "children": [], + "area": 4292245.045662999, + "iscrowd": 0, + "segmentation": [], + "text": "Jaime Zlamal, Marinela Elane, Lourdes Myjak and Andrei Osterman - experimental setup\nand conducting\n\nAlban de Crecy, Oleg Kurnasov - continuous culture device construction\nRoche - funding" + }, + { + "id": 1766, + "strid": "1dbc93c3-80db-4170-b342-9ce69ba71e61", + "image_id": 200567, + "image_name": "10301.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 30.82, + 18.49, + 157.6, + 115.58 + ], + "priority": -1, + "parents": [], + "children": [ + 1750, + 1751, + 1752, + 1753, + 1756, + 1755, + 1765, + 1754 + ], + "area": 569.8617999999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 1751, + "strid": "67456375-1e51-49bc-b219-2e8c4647fda5", + "image_id": 200567, + "image_name": "10301.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 89.379, + 149.978, + 1719.731, + 269.406 + ], + "priority": 1, + "parents": [ + 1766 + ], + "children": [], + "area": 13404.883662000002, + "iscrowd": 0, + "segmentation": [], + "text": "Genome Sequence Archive\n\na data repository for archiving sequence reads" + }, + { + "id": 1750, + "strid": "003dd3a9-f6df-49dd-b582-d05cce1f6f73", + "image_id": 200567, + "image_name": "10301.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 82.332, + 474.055, + 2188.437, + 141.43599999999998 + ], + "priority": 2, + "parents": [ + 1766 + ], + "children": [], + "area": 39029.896259999994, + "iscrowd": 0, + "segmentation": [], + "text": "Yanqing Wang, Junwei Zhu, Tingting Chen, Sisi Zhang, Wenming Zhao”\nBeijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, P.R. China" + }, + { + "id": 1765, + "strid": "d39baffc-4c63-46e4-9be5-679a3047fde7", + "image_id": 200567, + "image_name": "10301.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 89.768, + 331.462, + 1548.757, + 87.20499999999998 + ], + "priority": 3, + "parents": [ + 1766 + ], + "children": [], + "area": 29754.680816, + "iscrowd": 0, + "segmentation": [], + "text": "a data repository for archiving sequence reads" + }, + { + "id": 1752, + "strid": "b78deb92-fb96-4b21-a9df-a3c4dbc0a780", + "image_id": 200567, + "image_name": "10301.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 581.338, + 708.678, + 344.544, + 65.54700000000003 + ], + "priority": 4, + "parents": [ + 1766 + ], + "children": [ + 1762 + ], + "area": 411981.45116399997, + "iscrowd": 0, + "segmentation": [], + "text": "Instruction" + }, + { + "id": 1762, + "strid": "119fc033-d8fa-41ef-9b08-e99614a30eb9", + "image_id": 200567, + "image_name": "10301.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 68.311, + 810.062, + 1403.434, + 667.2319999999999 + ], + "priority": 5, + "parents": [ + 1752 + ], + "children": [], + "area": 55336.145282000005, + "iscrowd": 0, + "segmentation": [], + "text": "Genome Sequence Archive (GSA; http://bigd.big.ac.cn/gsa\nor http://gsa.big.ac.cn) is a data repository for archiving raw\nsequence data. As a core database resource of BIG Data\nCenter (http://bigd.big.ac.cn), GSA is built based on INSDC\ndata standards and structures and provides data archival\nservices for scientific communities not only in China but also\nthroughout the world. GSA accepts raw sequence reads\nproduced by a variety of sequencing platforms, stores both\nsequence reads and metadata, and provides free and\nunrestricted access to all publicly available data for worldwide\nscientific communities." + }, + { + "id": 1753, + "strid": "619663e7-0b73-4a6e-bac8-c84135fb21e3", + "image_id": 200567, + "image_name": "10301.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 250.365, + 1528.174, + 988.903, + 78.13499999999999 + ], + "priority": 6, + "parents": [ + 1766 + ], + "children": [ + 1764, + 1760 + ], + "area": 382601.28351000004, + "iscrowd": 0, + "segmentation": [], + "text": "Data submission and retrieval" + }, + { + "id": 1760, + "strid": "48c49add-3ca6-4efe-98ff-e46a4807a6e3", + "image_id": 200567, + "image_name": "10301.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 66.534, + 1648.366, + 1398.228, + 358.93499999999995 + ], + "priority": 7, + "parents": [ + 1753 + ], + "children": [], + "area": 109672.383444, + "iscrowd": 0, + "segmentation": [], + "text": "Designed for compatibility, GSA follows INSDC data\nstandards and structures. All data are organized into four\nobjects, i.e., BioProject, BioSample, Experiment, and Run.\nBased on these standardized data objects, GSA not only\nfacilitates data submission and deposition, but also enables\ndata sharing and exchange." + }, + { + "id": 1764, + "strid": "2181e747-519a-480c-846e-acf5e6061f21", + "image_id": 200567, + "image_name": "10301.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 88.107, + 2031.719, + 1338.071, + 1137.848 + ], + "priority": 8, + "parents": [ + 1753 + ], + "children": [], + "area": 179008.665933, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 1756, + "strid": "3a6a47e1-0a91-435d-92db-6cf91ee30228", + "image_id": 200567, + "image_name": "10301.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 249.262, + 3223.285, + 1031.996, + 71.81700000000001 + ], + "priority": 9, + "parents": [ + 1766 + ], + "children": [ + 1757, + 1763, + 1761 + ], + "area": 803442.46567, + "iscrowd": 0, + "segmentation": [], + "text": "Data structure and organization" + }, + { + "id": 1757, + "strid": "d9db59b1-5b54-43cb-bf83-b38631b26c00", + "image_id": 200567, + "image_name": "10301.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 71.192, + 3327.148, + 1397.454, + 251.14800000000014 + ], + "priority": 10, + "parents": [ + 1756 + ], + "children": [], + "area": 236866.32041599997, + "iscrowd": 0, + "segmentation": [], + "text": "GSA accepts data submissions from all over the world,\ncovers the spectrum of sequence reads generated by a\nvariety of sequencing platforms, and accommodates several\ncommonly used file formats, like FASTQ, BAM, and VCF." + }, + { + "id": 1761, + "strid": "9bc0d9f2-b964-443a-8650-5c292b7339c0", + "image_id": 200567, + "image_name": "10301.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1521.005, + 741.389, + 1397.0730000000003, + 477.2320000000001 + ], + "priority": 11, + "parents": [ + 1756 + ], + "children": [], + "area": 1127656.3759450002, + "iscrowd": 0, + "segmentation": [], + "text": "Since its inception in August 2015, GSA presents a dramatic\nincrease on data submissions in terms of the numbers of\nBioProjects and BioSamples, Experiments, and Runs, as well\nas file size. As of December 2016, GSA houses a total of 198\nBioProjects, 8674 BioSamples, 9263 Experiments and 10,745\nRuns for more than 80 species, submitted by more than 160\ndata providers from a total of 39 institutions, and archives\nmore than 200 TBs of sequence data." + }, + { + "id": 1763, + "strid": "505eadd7-3360-46c2-ab7d-ba1c2697e6c5", + "image_id": 200567, + "image_name": "10301.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1653.259, + 1277.223, + 1110.989, + 1399.114 + ], + "priority": 12, + "parents": [ + 1756 + ], + "children": [], + "area": 2111580.419757, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 1754, + "strid": "4dbd5a0a-2959-475e-85f4-080d72ac926e", + "image_id": 200567, + "image_name": "10301.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2046.379, + 2732.497, + 335.83600000000024, + 76.11599999999999 + ], + "priority": 13, + "parents": [ + 1766 + ], + "children": [ + 1759 + ], + "area": 5591724.478363, + "iscrowd": 0, + "segmentation": [], + "text": "Reference" + }, + { + "id": 1759, + "strid": "828281d3-e196-4111-9cc1-6c0b03c21ccb", + "image_id": 200567, + "image_name": "10301.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1519.139, + 2836.882, + 1401.381, + 335.12699999999995 + ], + "priority": 14, + "parents": [ + 1754 + ], + "children": [], + "area": 4309618.084598, + "iscrowd": 0, + "segmentation": [], + "text": "Yanqing Wang et al. GSA: Genome Sequence Archive.\nGenomics Proteomics Bioinformatics 2017, 15(1):14-18.\n\nBIG Data Center Members. The BIG Data Center: from\ndeposition to integration to translation. Nucleic Acids Res\n2017, 45(D1):D18-D24." + }, + { + "id": 1755, + "strid": "00b27e3d-0dd0-4a08-ba69-b70119944e80", + "image_id": 200567, + "image_name": "10301.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1938.942, + 3215.96, + 549.3899999999999, + 75.69399999999996 + ], + "priority": 15, + "parents": [ + 1766 + ], + "children": [ + 1758 + ], + "area": 6235559.91432, + "iscrowd": 0, + "segmentation": [], + "text": "Correspondence" + }, + { + "id": 1758, + "strid": "7592a5f7-cccc-465f-9eb7-61edba66efc9", + "image_id": 200567, + "image_name": "10301.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1518.964, + 3323.222, + 1406.4390000000003, + 246.78999999999996 + ], + "priority": 16, + "parents": [ + 1755 + ], + "children": [], + "area": 5047854.582008, + "iscrowd": 0, + "segmentation": [], + "text": "We sincerely thank Prof. Jingchu Luo and Prof. Weimin Zhu\nfor their valuable suggestions and constructive discussions on\nthis work.\n\nIf have any question, please contact Yanqing Wang." + }, + { + "id": 16951, + "strid": "22dc026e-92b5-443b-8ed4-dce12f651d5b", + "image_id": 201171, + "image_name": "116709.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 42.74, + 69.73, + 45.029999999999994, + 42.209999999999994 + ], + "priority": -1, + "parents": [], + "children": [ + 16953, + 16958, + 16952, + 16954, + 16966, + 16967, + 16961, + 16964 + ], + "area": 2980.2602, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 16952, + "strid": "8fd1d48b-8eaa-4fc7-8837-135e7fe4d2fe", + "image_id": 201171, + "image_name": "116709.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 125.269, + 24.292, + 826.356, + 67.057 + ], + "priority": 1, + "parents": [ + 16951 + ], + "children": [], + "area": 3043.0345480000005, + "iscrowd": 0, + "segmentation": [], + "text": "- The clinical and ethical practice of Deep Brain Stimulation:\nResults of an international survey of DBS experts and centers" + }, + { + "id": 16953, + "strid": "c8548ca2-5bd0-48a5-bbf5-16f829f89de3", + "image_id": 201171, + "image_name": "116709.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 94.475, + 103.031, + 892.48, + 38.00999999999999 + ], + "priority": 2, + "parents": [ + 16951 + ], + "children": [], + "area": 9733.853725, + "iscrowd": 0, + "segmentation": [], + "text": "Markus Christen (University of Zurich, Switzerland & University of Notre Dame, USA; christen@ethik.uzh.ch), Merlin Bittlinger (Humboldt\nUniversitat Berlin, Germany), Christian Ineichen (University of Zurich), Sabine Muller (Charité-Universitatsmedizin Berlin, Germany)" + }, + { + "id": 16954, + "strid": "3c250bd1-f5c1-4bd3-8de4-f2ee386096b9", + "image_id": 201171, + "image_name": "116709.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 90.459, + 180.328, + 148.12, + 17.455000000000013 + ], + "priority": 3, + "parents": [ + 16951 + ], + "children": [ + 16955, + 16960 + ], + "area": 16312.290552, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 16955, + "strid": "58aac6f2-87b3-478c-a166-b7524ba65beb", + "image_id": 201171, + "image_name": "116709.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 53.359, + 201.578, + 220.77199999999996, + 104.58599999999998 + ], + "priority": 4, + "parents": [ + 16954 + ], + "children": [], + "area": 10756.000502, + "iscrowd": 0, + "segmentation": [], + "text": "Deep brain stimulation (D85} has become d standard\ntherapy for some forms of movement csorders ands\ninvestigated for other neurlogieal and psychiatric\ndisorders although many scent clinical and ethical\nissuesare stil open. Inorder to obtain an overview of\nthe global practice on DBS we have performed 2\nsurvey among researchers, dlnicians and DBS centers\nthat addresses clnial and ethical problems curently\nGacsssed a rOtIBS nenatore leceodinne" + }, + { + "id": 16960, + "strid": "e1cdf862-129c-4fa6-8a42-6e772bcb4bf5", + "image_id": 201171, + "image_name": "116709.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 57.328, + 307.368, + 216.064, + 103.38799999999998 + ], + "priority": 5, + "parents": [ + 16954 + ], + "children": [], + "area": 17620.792704, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 16958, + "strid": "6aa337cb-4412-49ba-895a-836b8d779242", + "image_id": 201171, + "image_name": "116709.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 117.11, + 449.788, + 95.06599999999999, + 17.411999999999978 + ], + "priority": 6, + "parents": [ + 16951 + ], + "children": [ + 16959 + ], + "area": 52674.67268, + "iscrowd": 0, + "segmentation": [], + "text": "Methodology" + }, + { + "id": 16959, + "strid": "9b8f384f-ac8a-4f34-9010-d4965e5a44be", + "image_id": 201171, + "image_name": "116709.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 53.281, + 474.973, + 221.401, + 326.186 + ], + "priority": 7, + "parents": [ + 16958 + ], + "children": [], + "area": 25307.036413, + "iscrowd": 0, + "segmentation": [], + "text": "Researchers: The survey among DBS researchers and\ndlls was perforsed in two waves Between mid\n2011 and mid-2072 each of them induding two\nfllow-upsn thefist wave,esearchets identified ina\nlarge search pertormed by ust} were addressed who\npublished about DBS in Parkinson's esease since the\nearly 19905 The second wave addressed lniclans\nemerging fom a global search of DS centers tot\n712 persons were approached The survey question\npair was developed based on our previous seach\ninDBS [1-3] and has been rss-checked by abostdof\ninternational renowned DBS researchers The survey\nwas anonymized\n\nCenters‘The survey questionnaire or DBS centershas\nbeen pre-tstedn Delphi stud inciding al Swiss\ncentes (4. Using bblomety, ve have denied 12\ncounties that anked highest in lobal DBS research\ncompared tothe total research output in neurology\nand neuroscience Austla,Canada France, Germany,\nitaly Japan, Netherlands, Spain, Sweden, Sutzeland,\nUk.and USA For these counties we have performed\nanextended,nterne-bared serch to find cls tat\noffer DBS according to their webst;510 institutions\nhave been identied To thove centers ashort2-page\nquestionnaire hasbeen sent by postal malland two\nfllow-ups were performed (the second folow-upis\nSapling). The resus of this survey ere preliminary" + }, + { + "id": 16967, + "strid": "0e293c45-2bb7-4bc6-94f6-f2641093bdf9", + "image_id": 201171, + "image_name": "116709.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 351.495, + 189.316, + 404.044, + 21.02799999999999 + ], + "priority": 8, + "parents": [ + 16951 + ], + "children": [ + 16957, + 16963 + ], + "area": 66543.62742, + "iscrowd": 0, + "segmentation": [], + "text": "The “ethical landscape” of DBS & related survey results" + }, + { + "id": 16957, + "strid": "7cb93de9-d91e-46cd-a49e-44e76a08586a", + "image_id": 201171, + "image_name": "116709.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 321.67, + 224.727, + 468.392, + 517.291 + ], + "priority": 9, + "parents": [ + 16967 + ], + "children": [], + "area": 72287.93409000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 16963, + "strid": "e327968a-f561-4bec-9764-ddd158c6f161", + "image_id": 201171, + "image_name": "116709.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 331.592, + 751.072, + 438.40700000000004, + 41.56299999999999 + ], + "priority": 10, + "parents": [ + 16967 + ], + "children": [], + "area": 249049.466624, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 16961, + "strid": "8e9e9160-3d66-4b09-9179-722b2defbdec", + "image_id": 201171, + "image_name": "116709.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 900.052, + 183.857, + 87.57100000000003, + 13.742999999999995 + ], + "priority": 11, + "parents": [ + 16951 + ], + "children": [ + 16956 + ], + "area": 165480.860564, + "iscrowd": 0, + "segmentation": [], + "text": "Main Results" + }, + { + "id": 16956, + "strid": "7cda901a-337a-4b37-b1ed-12b3bcdc6142", + "image_id": 201171, + "image_name": "116709.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 834.456, + 202.728, + 217.04200000000003, + 338.964 + ], + "priority": 12, + "parents": [ + 16961 + ], + "children": [], + "area": 169167.595968, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 16964, + "strid": "7d3f829d-d585-4c7e-a928-ee8d17aaf412", + "image_id": 201171, + "image_name": "116709.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 902.019, + 572.294, + 83.53700000000003, + 13.440000000000055 + ], + "priority": 13, + "parents": [ + 16951 + ], + "children": [ + 16965 + ], + "area": 516220.06158599997, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 16965, + "strid": "13245e0a-b85a-49c0-91c8-3f6fed6e13ca", + "image_id": 201171, + "image_name": "116709.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 832.173, + 588.709, + 218.49800000000005, + 81.23000000000002 + ], + "priority": 14, + "parents": [ + 16964 + ], + "children": [], + "area": 489907.73465699994, + "iscrowd": 0, + "segmentation": [], + "text": "Our Survey expresses evaluations of experienced DBS\nexperts tht af optimistic with respect tothe curent\nuseand potential ofS. A mismatch of patent fears\nand isk az well asthe satisfaction gap cequite closer\ninvestigation. The proces of patient information and\nselection should be performed by mor interdscipin\nary teams which alse unclusie paychiateste." + }, + { + "id": 16966, + "strid": "2e0349de-7e72-469d-88ec-bff62e891bfe", + "image_id": 201171, + "image_name": "116709.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 843.716, + 699.61, + 199.36, + 16.865999999999985 + ], + "priority": 15, + "parents": [ + 16951 + ], + "children": [ + 16962 + ], + "area": 590272.15076, + "iscrowd": 0, + "segmentation": [], + "text": "Ongoing Research & Outlook" + }, + { + "id": 16962, + "strid": "6133334c-bcdc-4fc0-8499-d0e823468f52", + "image_id": 201171, + "image_name": "116709.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 831.704, + 718.817, + 220.164, + 81.22900000000004 + ], + "priority": 16, + "parents": [ + 16966 + ], + "children": [], + "area": 597842.9741679999, + "iscrowd": 0, + "segmentation": [], + "text": "We are currently finalizing Our center survey and 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"Title", + "bbox": [ + 219.552, + 491.048, + 2903.861, + 112.07899999999995 + ], + "priority": 1, + "parents": [ + 15485 + ], + "children": [], + "area": 107810.570496, + "iscrowd": 0, + "segmentation": [], + "text": "Tolerability issues with Oral Anticlabetic Agents" + }, + { + "id": 15487, + "strid": "91cf0943-9984-4708-aa95-5751265f01d1", + "image_id": 201111, + "image_name": "116616.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 339.273, + 629.77, + 2667.978, + 235.61900000000003 + ], + "priority": 2, + "parents": [ + 15485 + ], + "children": [], + "area": 213663.95721000002, + "iscrowd": 0, + "segmentation": [], + "text": "Cambra, R. F.*; Cruz, R. S. **\n\n* Graduate Student of Pharmacy, College of Health Technology of Coimbra - Polytechnic Institute of Coimbra. Portugal\n** Department of Pharmacy, College of Health Technology of Coimbra - Polytechnic Institute of Coimbra. Portugal" + }, + { + "id": 15488, + "strid": "cfc706ef-fd43-463d-837b-069872c68c45", + "image_id": 201111, + "image_name": "116616.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1501.76, + 953.922, + 413.8120000000001, + 52.321000000000026 + ], + "priority": 3, + "parents": [ + 15485 + ], + "children": [ + 15504 + ], + "area": 1432561.9027200001, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 15504, + "strid": "2839eb02-b3ff-4f06-a95a-6be421557576", + "image_id": 201111, + "image_name": "116616.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 280.521, + 1051.15, + 2814.698, + 416.192 + ], + "priority": 4, + "parents": [ + 15488 + ], + "children": [], + "area": 294869.64915000007, + "iscrowd": 0, + "segmentation": [], + "text": "As a general rule in type 2 diabetes can be a regular monitoring of blood glucose with oral antidiabetic agents. However, administration of\noral antidiabetic agents is often associated with adverse events for patients, influencing negatively either satisfaction, and treatment\nadherence. However, there are differences between antidiabetic classes of drugs, in consequence of their mechanisms of action. The\ntolerability is usually defined as the ability of the organism to sustain the effects of external agent.\n\nObjective: The purpose of this study was to analyze if oral therapy administered in patients with type II diabetes is well tolerated and its\ninfluence in the respective treatment tolerability." + }, + { + "id": 15493, + "strid": "411168db-8a15-4817-ae13-7f41ded29d4f", + "image_id": 201111, + "image_name": "116616.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1333.86, + 1502.781, + 752.2970000000003, + 56.624000000000024 + ], + "priority": 5, + "parents": [ + 15485 + ], + "children": [ + 15499, + 15492 + ], + "area": 2004499.4646599998, + "iscrowd": 0, + "segmentation": [], + "text": "Materials and Methods" + }, + { + "id": 15499, + "strid": "82a9911c-772b-4d94-b7d9-38c02ba410a3", + "image_id": 201111, + "image_name": "116616.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 284.164, + 1681.775, + 1442.739, + 412.2109999999998 + ], + "priority": 6, + "parents": [ + 15493 + ], + "children": [], + "area": 477899.9111, + "iscrowd": 0, + "segmentation": [], + "text": "We conducted a systematic review of literature without meta-analyse\nfrom the MEDLINE, between 2004-2011 about tolerability issues on\noral antidiabetic agents in type 2 diabetes..\n\nThe selection of reports was performed according to a methodology\nfor analysis of the title and abstract, and according to the criteria of\ninclusion." + }, + { + "id": 15492, + "strid": "38f19246-4631-4256-96a6-eef65160a55e", + "image_id": 201111, + "image_name": "116616.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1797.675, + 1652.359, + 1294.8700000000001, + 541.4470000000001 + ], + "priority": 7, + "parents": [ + 15493 + ], + "children": [ + 15490 + ], + "area": 2970404.4653249998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 15490, + "strid": "116255be-add4-41cc-894d-b28915969099", + "image_id": 201111, + "image_name": "116616.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2140.376, + 1606.046, + 606.2370000000001, + 32.465999999999894 + ], + "priority": 8, + "parents": [ + 15492 + ], + "children": [], + "area": 3437542.3132960005, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1: Stepwise literature search strategy" + }, + { + "id": 15498, + "strid": "99791ffa-f2f5-4803-b786-aad670078339", + "image_id": 201111, + "image_name": "116616.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1585.944, + 2243.109, + 242.3209999999999, + 55.01000000000022 + ], + "priority": 9, + "parents": [ + 15485 + ], + "children": [ + 15501, + 15496, + 15506, + 15502, + 15491, + 15497 + ], + "area": 3557445.259896, + "iscrowd": 0, + "segmentation": [], + "text": "PX RS" + }, + { + "id": 15496, + "strid": "ebc66693-6412-4e3c-b8f1-b9854b86a778", + "image_id": 201111, + "image_name": "116616.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 77.933, + 2339.508, + 1619.107, 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[] + }, + { + "id": 15501, + "strid": "9d632d47-25fa-4520-8a8e-bfe66a0e72a7", + "image_id": 201111, + "image_name": "116616.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2076.82, + 2354.222, + 1198.897, + 644.4769999999999 + ], + "priority": 13, + "parents": [ + 15498 + ], + "children": [ + 15495 + ], + "area": 4889295.334040001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 15495, + "strid": "873bcc63-e3bf-4c37-886d-c01f34b7a107", + "image_id": 201111, + "image_name": "116616.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2162.251, + 2392.02, + 1021.308, + 40.327999999999975 + ], + "priority": 14, + "parents": [ + 15501 + ], + "children": [], + "area": 5172147.63702, + "iscrowd": 0, + "segmentation": [], + "text": "Table 2: Incidence of tolerability inherent oral antidiabetics monotherapy" + }, + { + "id": 15502, + "strid": "9780526f-9fb1-4fc4-9c26-02a8e9ce3c46", + "image_id": 201111, + "image_name": "116616.png", + "category_id": 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+ "segmentation": [] + }, + { + "id": 15505, + "strid": "ff859786-8423-4f53-9b4d-ecbf258dbac8", + "image_id": 201111, + "image_name": "116616.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2107.204, + 3513.072, + 1157.2909999999997, + 35.72699999999986 + ], + "priority": 18, + "parents": [ + 15491 + ], + "children": [], + "area": 7402759.370688001, + "iscrowd": 0, + "segmentation": [], + "text": "Table 3: Incidence of tolerability inherent oral antidiabetics in combination therapy" + }, + { + "id": 15503, + "strid": "04ecfe50-da9b-4f33-accd-db39ec4bc8ed", + "image_id": 201111, + "image_name": "116616.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 683.805, + 4296.479, + 360.0010000000001, + 53.70600000000013 + ], + "priority": 19, + "parents": [ + 15485 + ], + "children": [ + 15494 + ], + "area": 2937953.822595, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion" + }, + { + "id": 15494, + "strid": "cbd79426-e5d3-406a-8f34-fd9926442f52", + "image_id": 201111, + "image_name": "116616.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 86.848, + 4419.695, + 1555.865, + 173.46399999999994 + ], + "priority": 20, + "parents": [ + 15503 + ], + "children": [], + "area": 383841.67136, + "iscrowd": 0, + "segmentation": [], + "text": "The oral hypoglycemic agents are associated with numerous adverse events,\nincluding hypoglycemia, edema, and gastrointestinal effects. These issues\naffect not only tolerability satisfaction, but also adherence to therapy." + }, + { + "id": 15507, + "strid": "e0be9c62-3149-4e55-bddc-6f7d4eedeb7b", + "image_id": 201111, + "image_name": "116616.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2339.277, + 4168.881, + 363.346, + 57.78899999999976 + ], + "priority": 21, + "parents": [ + 15485 + ], + "children": [ + 15489 + ], + "area": 9752167.439037, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 15489, + "strid": "05f779ce-f37c-4e79-abec-c0edf0fb6a25", + "image_id": 201111, + "image_name": "116616.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1734.904, + 4280.789, + 1580.1150000000002, + 388.52499999999964 + ], + "priority": 22, + "parents": [ + 15507 + ], + "children": [], + "area": 7426757.959256, + "iscrowd": 0, + "segmentation": [], + "text": "1 - Belcher et al. Elsevier. 2005; 2 - Charbonnel et al. Diabetes UK. 2005; 3 - Charbonnel et al.\nDiabetologia. 2005; 4 - Fujioka et al. Diabetes Obes Metab. 2005; 5 - Garber et al. Diabetes\nObes Metab. 2005; 6 - Matthews et al. Diabetes Metab Res Rev. 2005; 7 - Roberts et al. Clinical\nTherapeutics. 2005; 8 - Kahn et al. N Engl J Med. 2006; 9 - Rosenstock et al. Diabetes Obes\nMetab. 2006; 10 - Chao et al. Excerpta Medica. 2007; 11 - Davidson et al. Clinical Therapeutics.\n2007; 12 - Lewin et al. Clinical Therapeutics. 2007; 13 - Asche et al. Diabetes Obes Metab. 2008;\n14 - Asche et al. Drugs Aging. 2008; 15 - Seufert et al. Elsevier. 2008; 16 - Vexiau et al. Diabetes\nObes Metab. 2008; 17 - Pollack et al. Elsevier. 2010." + }, + { + "id": 34011, + "strid": "41cd8a19-d323-4087-a0aa-b17e5bde79aa", + "image_id": 201834, + "image_name": "117753.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 230.04, + 39.63, + 338.43000000000006, + 255.42000000000002 + ], + "priority": -1, + "parents": [], + "children": [ + 33989, + 33991, + 33986, + 33988, + 33990, + 33985, + 33987 + ], + "area": 9116.485200000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 33985, + "strid": "87df4cbf-ffdb-432c-a73c-4007ba296d27", + "image_id": 201834, + "image_name": "117753.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 184.147, + 412.924, + 2932.4, + 182.38699999999994 + ], + "priority": 1, + "parents": [ + 34011 + ], + "children": [], + "area": 76038.71582799999, + "iscrowd": 0, + "segmentation": [], + "text": "Effects of resistance training on peripheral bone mineral density and muscle\nstrength in adolescents with motor difficulties." + }, + { + "id": 33986, + "strid": "81986db0-7352-43f7-865d-b098190ccfc4", + "image_id": 201834, + "image_name": "117753.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 759.374, + 602.385, + 1779.9329999999998, + 140.899 + ], + "priority": 2, + "parents": [ + 34011 + ], + "children": [], + "area": 457435.50699, + "iscrowd": 0, + "segmentation": [], + "text": "Francisco C. Bervenotti Filho (MExSc), Beth Hands (PhD),\nFleur McIntyre (PhD), Tanya Blee (MSc), iafarikas (MD)" + }, + { + "id": 33987, + "strid": "9078c1d9-1d59-4fa8-85d9-06441050920b", + "image_id": 201834, + "image_name": "117753.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 110.807, + 786.119, + 384.862, + 48.78499999999997 + ], + "priority": 3, + "parents": [ + 34011 + ], + "children": [ + 33992 + ], + "area": 87107.488033, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 33992, + "strid": "cf7e4c3f-e653-4374-b683-432c16778459", + "image_id": 201834, + "image_name": "117753.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 141.892, + 881.524, + 1432.923, + 579.3729999999999 + ], + "priority": 4, + "parents": [ + 33987 + ], + "children": [], + "area": 125081.203408, + "iscrowd": 0, + "segmentation": [], + "text": "Adolescents with motor aE be at higher fracture\nrisk due to low bone mineral y (BMD), limited\nparticipation in high impact ical activities and higher\nincidence of falls. Strength and resistance training programs\nmay be effective in in non BMD. C\n\nAim of study Q°\n\nExamine the ax. of a 13-week equipment-constrai\n\nresistance training program on muscle strength and \\peripheral\nBMD me" + }, + { + "id": 33989, + "strid": "34ada3a7-b4fb-458f-a9ee-a8df696094a3", + "image_id": 201834, + "image_name": "117753.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 92.002, + 1500.033, + 294.218, + 49.028999999999996 + ], + "priority": 5, + "parents": [ + 34011 + ], + "children": [ + 34009, + 33995, + 34005, + 33994 + ], + "area": 138006.03606599997, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 34009, + "strid": "61623360-8d66-4389-92d4-dfbdb41416a9", + "image_id": 201834, + "image_name": "117753.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 150.225, + 1674.308, + 1203.086, + 335.9359999999999 + ], + "priority": 6, + "parents": [ + 33989 + ], + "children": [ + 34000 + ], + "area": 251522.91929999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 34000, + "strid": "f9fc4da4-1b34-46ff-af20-fdc5042c20a5", + "image_id": 201834, + "image_name": "117753.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 140.957, + 1596.919, + 523.797, + 47.975999999999885 + ], + "priority": 7, + "parents": [ + 34009 + ], + "children": [], + "area": 225096.911483, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1. Study participants" + }, + { + "id": 33994, + "strid": "6e059e39-ac77-4e39-87c9-9f6be8af0b88", + "image_id": 201834, + "image_name": "117753.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 143.05, + 2044.372, + 1423.027, + 262.14599999999996 + ], + "priority": 8, + "parents": [ + 33989 + ], + "children": [], + "area": 292447.4146, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 33995, + "strid": "3cbdd180-a265-4f53-862b-39f3da769c02", + "image_id": 201834, + "image_name": "117753.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 142.292, + 2331.849, + 416.12699999999995, + 218.29100000000017 + ], + "priority": 9, + "parents": [ + 33989 + ], + "children": [], + "area": 331803.45790800004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 34005, + "strid": "de42ae6c-5b70-47f8-ab28-cd9f29ea0691", + "image_id": 201834, + "image_name": "117753.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 133.431, + 2336.446, + 1515.755, + 1375.239 + ], + "priority": 10, + "parents": [ + 33989 + ], + "children": [ + 34002 + ], + "area": 311754.32622600003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 34002, + "strid": "2961f2cf-402d-4891-a5d5-744bd6597c0d", + "image_id": 201834, + "image_name": "117753.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 98.211, + 3747.678, + 1524.791, + 44.0949999999998 + ], + "priority": 11, + "parents": [ + 34005 + ], + "children": [], + "area": 368063.204058, + "iscrowd": 0, + "segmentation": [], + "text": "Figure1. Output: Limb cross section (top) and norms (bottom); and the pQCT (picture)" + }, + { + "id": 33990, + "strid": "c2765378-a620-4c4f-a7fc-d29208a89c43", + "image_id": 201834, + "image_name": "117753.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 117.163, + 3815.934, + 381.527, + 48.615999999999985 + ], + "priority": 12, + "parents": [ + 34011 + ], + "children": [ + 33999, + 34004 + ], + "area": 447086.275242, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 33999, + "strid": "732e85e7-d560-4e7b-8a00-d3a4aca4a8ec", + "image_id": 201834, + "image_name": "117753.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 115.877, + 3907.651, + 1321.664, + 178.04700000000003 + ], + "priority": 13, + "parents": [ + 33990 + ], + "children": [], + "area": 452806.87492699997, + "iscrowd": 0, + "segmentation": [], + "text": "A 13-week cardio, skills, and resistance-training program,\ncompleted twice per week for 90 minutes. Specific strength\n\nexercises targeted lower leg and forearm." + }, + { + "id": 34004, + "strid": "0ad5a374-7804-41ed-a566-2545bf8b6900", + "image_id": 201834, + "image_name": "117753.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 454.556, + 4077.127, + 754.645, + 506.17999999999984 + ], + "priority": 14, + "parents": [ + 33990 + ], + "children": [], + "area": 1853282.5406119998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 33988, + "strid": "22c1dbc8-83f0-4ef3-b3aa-d48394072ddc", + "image_id": 201834, + "image_name": "117753.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1601.341, + 800.195, + 265.4200000000001, + 48.865999999999985 + ], + "priority": 15, + "parents": [ + 34011 + ], + "children": [ + 33993, + 34006, + 33997, + 33996, + 34010, + 34008 + ], + "area": 1281385.061495, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 33993, + "strid": "2d803904-0277-4598-8ce3-9f7995838e41", + "image_id": 201834, + "image_name": "117753.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1650.065, + 888.114, + 1589.19, + 247.02199999999993 + ], + "priority": 16, + "parents": [ + 33988 + ], + "children": [], + "area": 1465445.8274100001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 34008, + "strid": "c0fd28f4-3d95-4b98-b23c-2457f6596061", + "image_id": 201834, + "image_name": "117753.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1619.743, + 1232.647, + 1534.3690000000001, + 687.1010000000001 + ], + "priority": 17, + "parents": [ + 33988 + ], + "children": [ + 34001 + ], + "area": 1996571.3497209998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 34001, + "strid": "d232c8de-e1e6-4e0f-a625-3873e3b27072", + "image_id": 201834, + "image_name": "117753.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1711.927, + 1949.057, + 1370.959, + 101.30700000000002 + ], + "priority": 18, + "parents": [ + 34008 + ], + "children": [], + "area": 3336643.302839, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2. Scatter plots for leg (N = 18) and arm strength (N = 21) with\nBMD measures at baseline for both groups" + }, + { + "id": 33996, + "strid": "4d1966a3-780e-44a3-aad1-1c6d3c427393", + "image_id": 201834, + "image_name": "117753.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1650.346, + 2088.532, + 1450.257, + 108.50900000000001 + ], + "priority": 19, + "parents": [ + 33988 + ], + "children": [], + "area": 3446800.432072, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 34010, + "strid": "4e325dca-6dd5-4662-9e61-8b8a6f1063a7", + "image_id": 201834, + "image_name": "117753.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1716.951, + 2327.5, + 1431.078, + 368.97699999999986 + ], + "priority": 20, + "parents": [ + 33988 + ], + "children": [ + 34007 + ], + "area": 3996203.4525, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 34007, + "strid": "f862841c-1e8a-42ef-b55b-e20e6854dc97", + "image_id": 201834, + "image_name": "117753.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1710.594, + 2253.022, + 1048.3630000000003, + 50.891000000000076 + ], + "priority": 21, + "parents": [ + 34010 + ], + "children": [], + "area": 3854005.915068, + "iscrowd": 0, + "segmentation": [], + "text": "Table 2. Strength measures pre and post intervention" + }, + { + "id": 33997, + "strid": "61fc25e5-4fb3-4b4c-ac84-ff0318f42d56", + "image_id": 201834, + "image_name": "117753.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1651.896, + 2731.189, + 1543.256, + 108.61299999999983 + ], + "priority": 22, + "parents": [ + 33988 + ], + "children": [], + "area": 4511640.184343999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 34006, + "strid": "8389cd42-f2bb-416d-871e-1867ae72c63e", + "image_id": 201834, + "image_name": "117753.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1703.122, + 2894.74, + 1372.928, + 773.585 + ], + "priority": 23, + "parents": [ + 33988 + ], + "children": [ + 34003 + ], + "area": 4930095.37828, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 34003, + "strid": "490b4a8d-3115-4c17-b759-71a821c48086", + "image_id": 201834, + "image_name": "117753.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1715.23, + 3718.56, + 1253.1020000000003, + 51.840000000000146 + ], + "priority": 24, + "parents": [ + 34006 + ], + "children": [], + "area": 6378185.6688, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3. Change in z-scores between pre and post intervention" + }, + { + "id": 33991, + "strid": "51fcabf6-f8fc-4401-9591-4c8a2154f027", + "image_id": 201834, + "image_name": "117753.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1712.434, + 3811.135, + 395.2180000000001, + 52.083000000000084 + ], + "priority": 25, + "parents": [ + 34011 + ], + "children": [ + 33998 + ], + "area": 6526317.15259, + "iscrowd": 0, + "segmentation": [], + "text": "5. Conclusions" + }, + { + "id": 33998, + "strid": "ddea2e5a-ecec-43ec-8380-11a6e2cbd2cd", + "image_id": 201834, + "image_name": "117753.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1762.205, + 3900.873, + 1498.621, + 631.9860000000003 + ], + "priority": 26, + "parents": [ + 33991 + ], + "children": [], + "area": 6874137.904965, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 29631, + "strid": "82876b14-2c2c-49a4-bb0a-b53c5f2b3f9c", + "image_id": 201669, + "image_name": "117489.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 3200.14, + 65.96, + 279.4100000000003, + 349.28000000000003 + ], + "priority": -1, + "parents": [], + "children": [ + 29629, + 29630, + 29623, + 29619, + 29617, + 29624, + 29618 + ], + "area": 211081.23439999996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 29617, + "strid": "b8fdfd52-fe84-40c9-b7ab-dcab647c5af2", + "image_id": 201669, + "image_name": "117489.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 124.156, + 178.531, + 2952.991, + 344.146 + ], + "priority": 1, + "parents": [ + 29631 + ], + "children": [], + "area": 22165.694836000002, + "iscrowd": 0, + "segmentation": [], + "text": "COMPARISON OF CIRCUIT COAGULATION AFTER AND BEFORE\nAPPLICATION OF AN eames FLOW-CHART. AS\nRETROSPECTIVE MONOCENTRIC ANALYSIS. @" + }, + { + "id": 29618, + "strid": "bbe9ab1a-3bbe-4fb6-9ad1-0d3dd0d3dfa6", + "image_id": 201669, + "image_name": "117489.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 115.83, + 594.836, + 3202.774, + 274.76099999999997 + ], + "priority": 2, + "parents": [ + 29631 + ], + "children": [], + "area": 68899.85388, + "iscrowd": 0, + "segmentation": [], + "text": "Ferraresi M, Merlo I, Giovinazzo G, Quercia AD, Leonardi G, Anania P, Guarena C, Cantaluppi V, Pacitti A*, Biancone L\n\nNephrology, Dialysis and Renal Transplantation Unit, University of Turin, AO Citta della Salute e della Scienza, Turin, Italy\n* Nephrology and Dialysis, ASO Santa Croce, Cuneo, Italy" + }, + { + "id": 29619, + "strid": "b7abd6d5-4957-4b58-85dc-9b12dee3bba8", + "image_id": 201669, + "image_name": "117489.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1103.861, + 950.083, + 455.1600000000001, + 74.93500000000006 + ], + "priority": 3, + "parents": [ + 29631 + ], + "children": [ + 29620 + ], + "area": 1048759.570463, + "iscrowd": 0, + "segmentation": [], + "text": "OBJECTIVES" + }, + { + "id": 29620, + "strid": "18a69fc1-5ede-4fd8-a395-620a62f231c4", + "image_id": 201669, + "image_name": "117489.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 115.83, + 1111.055, + 2414.57, + 577.277 + ], + "priority": 4, + "parents": [ + 29619 + ], + "children": [], + "area": 128693.50065, + "iscrowd": 0, + "segmentation": [], + "text": "Premature circuit clotting is a key problem in AKI patients undergoing CRRT. Prolonged\nIntermittent Renal Replacement Therapy (PIRRT) represents a dialysis modality combining the\ndetoxification and hemodynamic stability of CRRT with the advantage of conventional intermittent\ndialysis. However, an unpublished study in our Unit pointed out a coagulation rate of almost 50%\nof sessions, and tried}to elaborate a flow-chart to avoid circuit clotting and dialysis down-time\n(figure 1).\n\nThis study aims to compare clotting episodes in two groups of AKI patients subjected to PIRRT,\nafter the adoption of the anti-clotting flow-chart." + }, + { + "id": 29624, + "strid": "6092cb91-a832-49ea-b9e3-1135725d1e83", + "image_id": 201669, + "image_name": "117489.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1145.492, + 1791.02, + 374.67499999999995, + 69.38400000000001 + ], + "priority": 5, + "parents": [ + 29631 + ], + "children": [ + 29621, + 29622 + ], + "area": 2051599.0818399999, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 29622, + "strid": "ed3a2035-be00-4852-8400-bd8562033e28", + "image_id": 201669, + "image_name": "117489.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 118.606, + 1954.767, + 2417.3450000000003, + 421.856 + ], + "priority": 6, + "parents": [ + 29624 + ], + "children": [], + "area": 231847.094802, + "iscrowd": 0, + "segmentation": [], + "text": "A comparison between (a) clotting episodes in all PIRRT performed in the period 2009-10 and\n(b) a sample of PIRRT in 2011-1230%)\ndecreased from 19.6% to 10%, although non statistically\nsignificant (p=0.056)." + }, + { + "id": 29630, + "strid": "7bb79697-e784-404f-b4ff-e96759cebf76", + "image_id": 201669, + "image_name": "117489.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 676.454, + 3991.887, + 543.972, + 72.15999999999985 + ], + "priority": 11, + "parents": [ + 29631 + ], + "children": [ + 29627 + ], + "area": 2700327.928698, + "iscrowd": 0, + "segmentation": [], + "text": "CONCLUSIONS" + }, + { + "id": 29627, + "strid": "883c0396-d1c6-40f4-b7b3-45978b0c016d", + "image_id": 201669, + "image_name": "117489.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 118.606, + 4152.858, + 1656.895, + 646.6610000000001 + ], + "priority": 12, + "parents": [ + 29630 + ], + "children": [], + "area": 492553.875948, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction of the anti-coagulant flow chart allowed to\nsignificantly reduce clotting rate, also in case of sepsis and\nimpossibility to standard heparinization of the circuit, but 4t is\nstill negligible.\n\nThis is a preliminary analysis, of about half treatment performed in\nour Unit. The, final aim will be to correlate the reduction of\nclotting rate to each point of the flow-chart.\n\nAlthough, to further reduce clotting incidence in PIRRT, it can be\nnecessary 0 apply additional strategies, such as the use of citrate." + }, + { + "id": 29629, + "strid": "c86e5f73-cbe8-4a99-a0ac-356ca66a3daf", + "image_id": 201669, + "image_name": "117489.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2422.161, + 3978.01, + 505.1170000000002, + 77.71000000000004 + ], + "priority": 13, + "parents": [ + 29631 + ], + "children": [ + 29628 + ], + "area": 9635380.67961, + "iscrowd": 0, + "segmentation": [], + "text": "REFERENCES:" + }, + { + "id": 29628, + "strid": "e6766a03-406f-45ca-81a8-0c19fcbea01b", + "image_id": 201669, + "image_name": "117489.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1919.819, + 4144.532, + 1473.7199999999998, + 646.6610000000001 + ], + "priority": 14, + "parents": [ + 29629 + ], + "children": [], + "area": 7956751.279708, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 112844, + "strid": "720ce25b-840a-4609-884f-6d8db9b622e9", + "image_id": 204879, + "image_name": "13406.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 46.07, + 69.2, + 86.21000000000001, + 62.86 + ], + "priority": -1, + "parents": [], + "children": [ + 112824, + 112817, + 112822, + 112815, + 112819, + 112826, + 112821, + 112820, + 112818, + 112843, + 112825, + 112816, + 112823 + ], + "area": 3188.0440000000003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 112815, + "strid": "f9b6049a-58a9-44c3-ae3a-939cde9af471", + "image_id": 204879, + "image_name": "13406.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 64.181, + 30.831, + 491.589, + 39.462 + ], + "priority": 1, + "parents": [ + 112844 + ], + "children": [], + "area": 1978.7644109999999, + "iscrowd": 0, + "segmentation": [], + "text": "Distill, a random forest, xgboost, and deep neural network based ensemble\nlearner, provides class leading DNA variant pathogenicity prediction" + }, + { + "id": 112843, + "strid": "ba82cb08-f143-4695-b66c-d6e8bba19ef5", + "image_id": 204879, + "image_name": "13406.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 581.322, + 27.007, + 193.601, + 63.88799999999999 + ], + "priority": 2, + "parents": [ + 112844 + ], + "children": [], + "area": 15699.763254000001, + "iscrowd": 0, + "segmentation": [], + "text": "See\nhitps://github.com/davemeg/Distl\nPom Veena)\neen" + }, + { + "id": 112816, + "strid": "b489897e-8eb0-46bc-ad9b-9bf4982f9d57", + "image_id": 204879, + "image_name": "13406.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 57.82, + 136.7, + 96.85400000000001, + 16.552999999999997 + ], + "priority": 3, + "parents": [ + 112844 + ], + "children": [ + 112827 + ], + "area": 7903.994, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 112827, + "strid": "627de048-b5c0-4f9f-8f95-ba542912be09", + "image_id": 204879, + "image_name": "13406.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 57.701, + 167.844, + 115.793, + 872.0829999999999 + ], + "priority": 4, + "parents": [ + 112816 + ], + "children": [], + "area": 9684.766644, + "iscrowd": 0, + "segmentation": [], + "text": "Identification of pathagesic\ncava) ro hams\nbiome or genane\nsequencing (WGS) is\ncual ad ica tk,\nWith the deta eduction\nin sequencing cost tan\nicessinly common task,\nEven afer fering for are\ncoding a splicing vain,\nnumeous ped varanl\nremain fo est pains,\n\nCurrent prorization\nsutepies use combiztion\nof in slic predictions and\nknowledge of likely\ndeleterious pens forthe\ncondition, log with are\narty of scoring mets,\nPopular metres lade\nconservation an nso\nfunctionality Sores ike\nGERP SIFT, GERP,CADD,\ntod REVEL. To beter gue\navian analysis, we wea\nnavel and broad dataset\nrareandichlyannated\nvariants to uain amendlan\nduete DNA variant\nathogencty node\n\nWe carted a machine\ncaning input dase\neld high quay\nClinVar pathogeicbenien\ndataset, 428 saved retinal\ndegencaton WOS cases,\nsd ar vais fom\nsuomaAD. The buadted of\nthousands of vans were\nrh annotated with\nhundreds of variant mets\ncluding constrained coding\nreponse), ENCODE\ncvomatin data, GTEX gene\nexpression dal, abd ober\npathogenicity mevies(e.\nREVEL, FATHNM,\nMetSVM)\n\n \n\nThe advantage of tis\nste isthe use ofa broad,\ncrated set frat benign\nvain anda ihe et of\nantations. Ou dst,\nwe sed with ado\nfrst an ghost model 10\nodie DNA variant\npathogenic highligh cer,\nthe EXAC mssese and loss\nof ition Z-scores, Phylo,\nCADD, and gnomAD\npopulation mete asthe\nst ei sores, We then\ntana deep LSTM neural\nework rndel ad merged\nith the rand fst tid\ntsboost modesto eee a\ncasemble learner, Dist,\nwih las leading\npathogenicity prediction\nfron diverse set of\nnmmmmmmatistzscts 7\"," + }, + { + "id": 112817, + "strid": "8175c020-dbe6-440a-9867-016de402cee6", + "image_id": 204879, + "image_name": "13406.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 200.663, + 93.282, + 41.14500000000001, + 16.361999999999995 + ], + "priority": 5, + "parents": [ + 112844 + ], + "children": [ + 112835 + ], + "area": 18718.245966, + "iscrowd": 0, + "segmentation": [], + "text": "Flow" + }, + { + "id": 112835, + "strid": "54ea3b87-7163-4ee2-b15a-8999d6c3fd98", + "image_id": 204879, + "image_name": "13406.png", + "category_id": 2, + "category_name": 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They have ben iter to oly ase coding\nor splicing variants with population AF below 0.01" + }, + { + "id": 112822, + "strid": "de2004d3-8de4-4160-a8f7-b1c4ba9fce6c", + "image_id": 204879, + "image_name": "13406.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 523.528, + 723.966, + 182.279, + 18.388000000000034 + ], + "priority": 24, + "parents": [ + 112844 + ], + "children": [ + 112841, + 112831, + 112833 + ], + "area": 379016.472048, + "iscrowd": 0, + "segmentation": [], + "text": "Assess Performance III" + }, + { + "id": 112833, + "strid": "168c63c2-e0bd-4780-b783-04b65a437438", + "image_id": 204879, + "image_name": "13406.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 525.21, + 749.506, + 228.00599999999997, + 22.865999999999985 + ], + "priority": 25, + "parents": [ + 112822 + ], + "children": [], + "area": 393648.04626000003, + "iscrowd": 0, + "segmentation": [], + "text": "How many non-pathogenic variants {2,0°0 total) get called\npathogenic?" + }, + { + "id": 112841, + "strid": "2a920e85-9709-447b-a11d-6b8779bfde44", + "image_id": 204879, + "image_name": "13406.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 523.793, + 783.528, + 266.236, + 84.93000000000006 + ], + "priority": 26, + "parents": [ + 112822 + ], + "children": [], + "area": 410406.48170400003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 112831, + "strid": "d7936e9e-b50c-45f9-989f-befe2e078173", + "image_id": 204879, + "image_name": "13406.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 523.862, + 873.1, + 267.668, + 34.38700000000006 + ], + "priority": 27, + "parents": [ + 112822 + ], + "children": [], + "area": 457383.91219999996, + "iscrowd": 0, + "segmentation": [], + "text": "Model score cutofls selected by picking the value that maximizes the\nprecision frm call of 0.18 190.0 forthe Colombia exome\naeeeer" + }, + { + "id": 112823, + "strid": "a36e4aa6-0e57-4286-a01b-2b7c9f1eebfd", + "image_id": 204879, + "image_name": "13406.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 524.084, + 912.693, + 94.74099999999999, + 21.562999999999988 + ], + "priority": 28, + "parents": [ + 112844 + ], + "children": [ + 112832 + ], + "area": 478327.79821199994, + "iscrowd": 0, + "segmentation": [], + "text": "Take Aways" + }, + { + "id": 112832, + "strid": "0a888795-7bd2-4c63-8382-7b0b63bf74b8", + "image_id": 204879, + "image_name": "13406.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 524.147, + 937.813, + 258.22799999999995, + 137.50799999999992 + ], + "priority": 29, + "parents": [ + 112823 + ], + "children": [], + "area": 491551.87051100004, + "iscrowd": 0, + "segmentation": [], + "text": "‘While Dietil ls conceptually claniier te tools Hie Metal or\nREVEL, Disil es huge suber of ae presumay ow\npathogenic, variants\n\nBacase ofthis, Disilis far mote discriinuing ia removing\npathogenic re variants in rea oe walsic situations (hte no\npathogenic variants subtncallycatamber pathogen varias)\ncoated o REVEL CADD. et\n\nIlan on pe-cmpating Disl cores on hunan coding vasition\nsoon. Check the Distilpthb page (0 ile pane above)\n\nIam looking for more large cobs af saved WOSiexomes\nSucthes toes Doss" + }, + { + "id": 50968, + "strid": "6adde3f3-331e-48b0-b737-06619bdf2b01", + "image_id": 202504, + "image_name": "118785.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 245.36, + 458.3, + 297.17999999999995, + 307.09 + ], + "priority": -1, + "parents": [], + "children": [ + 50957, + 50950, + 50953, + 50964, + 50951, + 50952, + 50955, + 50963, + 50956, + 50954 + ], + "area": 112448.48800000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 50950, + "strid": "6be5e6c3-8336-4fdb-bb09-9615b23d0053", + "image_id": 202504, + "image_name": "118785.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 381.914, + 397.282, + 3265.8590000000004, + 268.614 + ], + "priority": 1, + "parents": [ + 50968 + ], + "children": [], + "area": 151727.557748, + "iscrowd": 0, + "segmentation": [], + "text": "Palatal plate implantation for the treatment of dysarthria and\nsevere hypernasality in ALS patients" + }, + { + "id": 50951, + "strid": "34e7c720-d62f-4acc-9eee-13f838180c80", + "image_id": 202504, + "image_name": "118785.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 640.673, + 691.024, + 2622.12, + 158.466 + ], + "priority": 2, + "parents": [ + 50968 + ], + "children": [], + "area": 442720.419152, + "iscrowd": 0, + "segmentation": [], + "text": "Pasian V.', Piumetto E.', Ceruti P. 2, Moglia C.1, Calvo A.', Gassino G.2, Chid A.1\n\n‘ALS Centre, “Rita Levi Montalcini’ Department of Neuroscience, Torino Italy 2 Dental School, Torino, Italy" + }, + { + "id": 50952, + "strid": "ecf42c5c-1b0a-4d8a-86ca-454f3b84862a", + "image_id": 202504, + "image_name": "118785.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 80.902, + 1007.164, + 257.52, + 45.128999999999905 + ], + "priority": 3, + "parents": [ + 50968 + ], + "children": [ + 50958 + ], + "area": 81481.581928, + "iscrowd": 0, + "segmentation": [], + "text": "Background" + }, + { + "id": 50958, + "strid": "88850371-f5c7-46ee-9522-674032c1650f", + "image_id": 202504, + "image_name": "118785.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 79.256, + 1082.779, + 1079.402, + 544.404 + ], + "priority": 4, + "parents": [ + 50952 + ], + "children": [], + "area": 85816.732424, + "iscrowd": 0, + "segmentation": [], + "text": "Dysarthria occurs in more than 80% of ALS patients and may\ncause major disability, reducing significantly quality of life. In\nthese patients, dysarthria is typically characterized by muscle\nweakness and hyposthenia of buccofacial districts, causing\ninaccurate production of phonemes sometimes associated to\ndysphonia and hypernasality. Insufficiency of velopharyngeal\nand oral articulatory valves can make the effective production\nof coordinated speech gestures impossible and compromise\nvoice quality In fact, the velopharyngeal mechanism provides\nthe sound and/or airstream between the oral and nasal\ncavities and influences the voice quality perceived by the\nlistener." + }, + { + "id": 50963, + "strid": "345ecff4-e71d-4b48-b2c2-6ea9330966d9", + "image_id": 202504, + "image_name": "118785.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1188.52, + 1070.62, + 774.1790000000001, + 580.31 + ], + "priority": 5, + "parents": [ + 50968 + ], + "children": [], + "area": 1272453.2824, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 50964, + "strid": "e828987c-0a31-4f60-b155-46d1e0ab988a", + "image_id": 202504, + "image_name": "118785.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2012.426, + 1061.922, + 579.9990000000003, + 673.2759999999998 + ], + "priority": 6, + "parents": [ + 50968 + ], + "children": [], + "area": 2137039.442772, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 50953, + "strid": "49cbcab3-36f1-4e6a-88bd-c2cee75d12f2", + "image_id": 202504, + "image_name": "118785.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 80.311, + 1701.116, + 199.57899999999998, + 42.77299999999991 + ], + "priority": 7, + "parents": [ + 50968 + ], + "children": [ + 50959 + ], + "area": 136618.32707600002, + "iscrowd": 0, + "segmentation": [], + "text": "Objective" + }, + { + "id": 50959, + "strid": "19a72931-1203-49ac-a43b-f60cea2755ca", + "image_id": 202504, + "image_name": "118785.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 79.042, + 1775.859, + 1111.394, + 412.7890000000002 + ], + "priority": 8, + "parents": [ + 50953 + ], + "children": [], + "area": 140367.447078, + "iscrowd": 0, + "segmentation": [], + "text": "Prosthetic treatments combined with speech therapy are often\nindicated for these patients. The objective of the palatal lift is to\nimprove resonance by displacing the soft palate to the level of\nnormal palate elevation, decreasing the velopharyngeal port to\neliminate hypernasality and nasal emission of air during the\nproduction of oral consonant sounds. The aim of these study is\nto evaluate if a palatal plate, stiffing the soft palate, can improve\ndysarthria and severe hypernasality of a patient with bulbar\nALS, increasing the intelligibility of soeech." + }, + { + "id": 50954, + "strid": "c81c799c-9534-4312-9bc2-ad1bf3420f0b", + "image_id": 202504, + "image_name": "118785.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 81.823, + 2259.807, + 179.25100000000003, + 35.22699999999986 + ], + "priority": 9, + "parents": [ + 50968 + ], + "children": [ + 50960, + 50962, + 50961 + ], + "area": 184904.18816099997, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 50960, + "strid": "628d2fe1-5965-4c62-8a5a-1fe326cb9fe3", + "image_id": 202504, + "image_name": "118785.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 78.219, + 2378.941, + 1151.173, + 740.9850000000001 + ], + "priority": 10, + "parents": [ + 50954 + ], + "children": [], + "area": 186078.38607899996, + "iscrowd": 0, + "segmentation": [], + "text": "A 60-years-old woman with one year history of predominant upper\nmotor neuron disease (bulbar onset) was referred for a phoniatrics\nassessment. Clinical and instrumental examination showed _ signs\nof mild dysarthria, severe hypomobility of velum palatinum,\nreduced strength and precision of exercises of tongue, mouth and\nface, normotrophic tongue, no signs of dysphagia.\n\nDuring evaluations she informed us that had already started six\nmonths before speech therapy (one session per week).\n\nShe underwent rhinomanometry and acoustic analysis of voice\nthrough a parametric, sophisticated software (Multi-Dimensional\nVoice Profile, Computerized Speech Lab) in order to obtain\nreliable indications about the acoustic characteristics. of vocal\nquality in this case. We used this for detecting good indexes of\nacoustic evaluation for this patient, in order to use it together with\ntraditional endoscopic and perceptive analysis.\n\nThe disease progression was measured through ALSFRS-R." + }, + { + "id": 50961, + "strid": "ebe4533d-f17f-45c6-b31d-b6a533535d2c", + "image_id": 202504, + "image_name": "118785.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 60.864, + 3171.309, + 1209.96, + 1478.0330000000004 + ], + "priority": 11, + "parents": [ + 50954 + ], + "children": [], + "area": 193018.550976, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 50962, + "strid": "91e98ab0-0132-42d6-a40a-97f35e8199ff", + "image_id": 202504, + "image_name": "118785.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1373.103, + 1857.025, + 1113.6350000000002, + 1437.2649999999999 + ], + "priority": 12, + "parents": [ + 50954 + ], + "children": [], + "area": 2549886.598575, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 50955, + "strid": "00319130-387c-4e9b-857b-27b482e30371", + "image_id": 202504, + "image_name": "118785.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2625.527, + 999.967, + 157.53099999999995, + 34.500000000000114 + ], + "priority": 13, + "parents": [ + 50968 + ], + "children": [ + 50966 + ], + "area": 2625440.357609, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 50966, + "strid": "641d73c6-f2d7-4050-a0eb-fa940d77b509", + "image_id": 202504, + "image_name": "118785.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2623.92, + 1097.208, + 1259.9920000000002, + 2976.11 + ], + "priority": 14, + "parents": [ + 50955 + ], + "children": [], + "area": 2878986.01536, + "iscrowd": 0, + "segmentation": [], + "text": "The patient was adapted to a palatal plate on measure after dental\nimpression; this device has a retainer for removable prostheses located\nin the dorso-palatal area of the mouth. The acrylic plates elevate the soft\npalate and reduce palatopharyngeal incompetency. The patient was\nadvised to use the plate during all hours of the day except during meal\ntimes.\n\nShe continued speech therapy regularly.\n\nAfter a period of adjustment to the palatal plate of about 15 days the\npatient underwent a clinical and instrumental re-evaluation.\n\nTotal score of ALSFRS-R before implantation was 43 with 2 of speech\nscore. After palatal plate the total score of ALSFRS-R was 38 but speech\nscore was increased from 2 to 3.\n\nIt is well known that the MDVP system provides 33 measures of vocal\nsignal.\n\nIn the present study, only 4 out of the 30 parameters implemented by the\nsoftware have been considered. These parameters are the more\nrepresentative and significant in describing restored vocal functional in\nthis case: VTI, FO, DUV, DSH.\n\nVTI. Voice Turbulence Index measures the relative energy level of high\nfrequency noise. It correlates primarily with the turbulence caused by\nincomplete or loose adduction of the vocal folds and less air leak during\nvocalization.\n\nFo (Hz). Average Fundamental Frequency for all extracted pitch periods.\n\nDUV (%). Degree of Voiceless is an estimated relative evaluation of non-\nharmonic areas (where Fo cannot be detected) in the voice sample. In\nthe case of non-sustained phonation from the beginning to the end of the\ndata acquisition, DUV will evaluate also the pauses before, after and/or\nbetween the voice sample(s).\n\nDSH (%). Degree of Sub-Harmonics is an estimated relative evaluation\nof sub-harmonic to Fo components in the voice sample.\n\nAt rhinomanometry with palatal plate we observed an increased in both\ninspiratory and expiratory nasal resistance to confirm the presence of\nminor air leak free and so more resistance.\n\nThe voice analysis showed an improvement of the parameters, the ratio\nof turbulence in the pronunciation of the phoneme /a/ with palatal plate\napproaches the average values compared to the reference; this data\ncould indicate that lower air leakage can have a positive effect on the\nattack speech, which is less blown and generally a minor component of\nair in the vocal production.\n\nWe observed that the value of DSH was reduced to zero (0) with palatal\nplate; this could represent a lower recruiting of supraglottic balance, that\ncan be increased by excessive air leak which leads to a significant\nconstriction at the level of the entire vocal tract-\n\nThe most significant data is related to DUV: this is the result of an\nimprovement in sustained phonation from the beginning to the end.\n\nIt is possible to observe a reduction of FO with palatal plate; this could\nbe another sign of less forced voice.\n\nThe patient and her family referred an improvement in both quality of\nspeech and intelligibility.\n\nThe patient is still undergoing speech therapy in order to improve\npneumophonic coordination and vocal attack and to optimize the benefits\nof the palatal plate." + }, + { + "id": 50957, + "strid": "575004f4-da9c-4f0c-9342-8f58ce7466f1", + "image_id": 202504, + "image_name": "118785.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1649.932, + 3487.802, + 575.0309999999997, + 36.679999999999836 + ], + "priority": 15, + "parents": [ + 50968 + ], + "children": [ + 50965 + ], + "area": 5754636.129464, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion and conclusion" + }, + { + "id": 50965, + "strid": "7f5be8e4-b9a2-401d-bea3-95f8e62ccd6f", + "image_id": 202504, + "image_name": "118785.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1362.677, + 3562.297, + 1148.9000000000003, + 598.0589999999997 + ], + "priority": 16, + "parents": [ + 50957 + ], + "children": [], + "area": 4854260.189069, + "iscrowd": 0, + "segmentation": [], + "text": "Although data are limited to a single case, the results are very\ninteresting.\n\nThe palatal plate is indicated in ALS patients with medium or\nsevere rhinolalia but good articulation (low grade of dysarthria)\nsupported by good facial praxis.\n\nThe use of palatal plate is well tolerated and can improve\ndysarthria and severe hypernasality of patients with bulbar ALS,\nincreasing the results of speech therapy and the intelligibility of\nspeech." + }, + { + "id": 50956, + "strid": "89a4af10-04b6-4a54-bbb3-9bb131f2bda4", + "image_id": 202504, + "image_name": "118785.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2655.89, + 4142.087, + 141.75999999999976, + 19.89300000000003 + ], + "priority": 17, + "parents": [ + 50968 + ], + "children": [ + 50967 + ], + "area": 11000927.44243, + "iscrowd": 0, + "segmentation": [], + "text": "References:" + }, + { + "id": 50967, + "strid": "d86ea557-e806-4e39-afd4-74becaa5cba9", + "image_id": 202504, + "image_name": "118785.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2656.348, + 4187.693, + 1185.5529999999999, + 505.6999999999998 + ], + "priority": 18, + "parents": [ + 50956 + ], + "children": [], + "area": 11123969.925164001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143301, + "strid": "0454ee41-4a7f-4645-bd4d-f06f1c475f54", + "image_id": 206070, + "image_name": "17319.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 69.92, + 45.77, + 178.61, + 178.61999999999998 + ], + "priority": -1, + "parents": [], + "children": [ + 143283, + 143285, + 143287, + 143284, + 143288, + 143286 + ], + "area": 3200.2384, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143283, + "strid": "c5fcc354-13ac-4d5c-9141-b376b8543072", + "image_id": 206070, + "image_name": "17319.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 584.107, + 56.426, + 1580.194, + 186.21800000000002 + ], + "priority": 1, + "parents": [ + 143301 + ], + "children": [], + "area": 32958.821582, + "iscrowd": 0, + "segmentation": [], + "text": "PhenPath identifies biological functions\nunderlying phenotypes" + }, + { + "id": 143284, + "strid": "a8078cca-84a7-4a8e-a5d8-b6df72eaa45e", + "image_id": 206070, + "image_name": "17319.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 803.164, + 278.628, + 1152.262, + 104.59300000000002 + ], + "priority": 2, + "parents": [ + 143301 + ], + "children": [], + "area": 223783.978992, + "iscrowd": 0, + "segmentation": [], + "text": "Babbi G, Martelli PL, Casadio R\nBologna Biocomputing Group — University of Bologna, Italy" + }, + { + "id": 143285, + "strid": "95db1be2-efb3-4027-a948-985d88066b56", + "image_id": 206070, + "image_name": "17319.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1235.631, + 408.866, + 283.02700000000004, + 38.62700000000001 + ], + "priority": 3, + "parents": [ + 143301 + ], + "children": [ + 143289 + ], + "area": 505207.50444600004, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 143289, + "strid": "dc9d3f16-fa18-40ee-b82d-0950c2a939dd", + "image_id": 206070, + "image_name": "17319.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 36.896, + 475.814, + 2647.709, + 143.281 + ], + "priority": 4, + "parents": [ + 143285 + ], + "children": [], + "area": 17555.633344, + "iscrowd": 0, + "segmentation": [], + "text": "A major challenge in understanding the molecular mechanisms at the basis of diseases is the co-occurrence of different, apparently unrelated,\nphenotypes. Leveraging the available information on the relations among genes, diseases and phenotypes, we developed PhenPath[1], a\nresource dedicated to collect and enrich knowledge on molecular functions and biological processes underlying the occurrence of phenotypes." + }, + { + "id": 143286, + "strid": "36ea6d37-070d-4c0b-98d2-ad461bfe8898", + "image_id": 206070, + "image_name": "17319.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1699.825, + 679.216, + 728.7899999999997, + 40.551000000000045 + ], + "priority": 5, + "parents": [ + 143301 + ], + "children": [ + 143291, + 143290, + 143295, + 143292, + 143296, + 143293, + 143294 + ], + "area": 1154548.3372, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 143291, + "strid": "53285846-d017-41c9-9a20-bd33074e4a54", + "image_id": 206070, + "image_name": "17319.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 56.706, + 725.702, + 303.155, + 274.818 + ], + "priority": 6, + "parents": [ + 143286 + ], + "children": [], + "area": 41151.657612, + "iscrowd": 0, + "segmentation": [], + "text": "y PhenPath\n\nassociates\nphenotypes to\npathways exploiting\nrelationships among\ngenes, diseases &\n» phenotypes" + }, + { + "id": 143292, + "strid": "bb9f3c01-175a-40e1-a5e8-e27a156150de", + "image_id": 206070, + "image_name": "17319.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 91.459, + 1127.77, + 267.332, + 188.73700000000008 + ], + "priority": 7, + "parents": [ + 143286 + ], + "children": [], + "area": 103144.71643, + "iscrowd": 0, + "segmentation": [], + "text": "Associations\nbetween diseases\nand phenotypes\nderive from HPO\nand OMIM" + }, + { + "id": 143290, + "strid": "31100115-57d3-4c56-b463-db4422d68fe1", + "image_id": 206070, + "image_name": "17319.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 389.474, + 703.375, + 997.665, + 670.5149999999999 + ], + "priority": 8, + "parents": [ + 143286 + ], + "children": [], + "area": 273946.27475, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143293, + "strid": "955912e2-48b8-4337-91b9-731b471cd089", + "image_id": 206070, + "image_name": "17319.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 563.914, + 1428.195, + 323.2660000000001, + 194.50800000000004 + ], + "priority": 9, + "parents": [ + 143286 + ], + "children": [], + "area": 805379.1552299999, + "iscrowd": 0, + "segmentation": [], + "text": "Given a set of\nphenotypes, it\nretrieves the shared\nbiological pathways,\ngenes and diseases”" + }, + { + "id": 143294, + "strid": "66f77d65-79e3-4087-867f-558799a64f08", + "image_id": 206070, + "image_name": "17319.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 981.454, + 1446.091, + 266.1969999999999, + 152.385 + ], + "priority": 10, + "parents": [ + 143286 + ], + "children": [], + "area": 1419271.796314, + "iscrowd": 0, + "segmentation": [], + "text": "7,137 phenotypes\n(the 47% of HPO)\nassociated with\n6,838 pathways" + }, + { + "id": 143295, + "strid": "78bec347-8406-4836-af1e-abb8462df294", + "image_id": 206070, + "image_name": "17319.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1414.804, + 752.432, + 1301.438, + 342.8399999999999 + ], + "priority": 11, + "parents": [ + 143286 + ], + "children": [], + "area": 1064543.803328, + "iscrowd": 0, + "segmentation": [], + "text": "PhenPath associates phenotypes with diseases and genes via\neDGAR[2], and it retrieves functional annotation for each phenotype\nafter an enrichment procedure using NET-GE[3]. Network-based\nenrichment analysis identifies significantly over-represented biological\nfunctions and pathways, considering Gene Ontology (Molecular\nFunction, Biological Process and Cellular Component), KEGG and\nReactome pathways, as reported in the following table:" + }, + { + "id": 143296, + "strid": "0673a0d4-3f8a-4010-8597-f1931b83c96f", + "image_id": 206070, + "image_name": "17319.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1427.565, + 1113.307, + 1279.118, + 616.1600000000001 + ], + "priority": 12, + "parents": [ + 143286 + ], + "children": [], + "area": 1589318.107455, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143287, + "strid": "fe00c10b-6296-49f8-aaf7-f4051d16f96b", + "image_id": 206070, + "image_name": "17319.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1024.468, + 1763.179, + 694.3489999999999, + 51.58400000000006 + ], + "priority": 13, + "parents": [ + 143301 + ], + "children": [ + 143298, + 143297, + 143299 + ], + "area": 1806320.4637720003, + "iscrowd": 0, + "segmentation": [], + "text": "PhenPathTOOL: a case study" + }, + { + "id": 143298, + "strid": "9a1ec84d-8f46-4eb6-a2b7-568212d0edb0", + "image_id": 206070, + "image_name": "17319.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 47.934, + 1859.541, + 1300.025, + 594.7830000000001 + ], + "priority": 14, + "parents": [ + 143287 + ], + "children": [], + "area": 89135.238294, + "iscrowd": 0, + "segmentation": [], + "text": "Based on PhenPath, we developed a tool that associates a set of\nphenotypes (possibly co-occurring in a disease) with potentially\ninvolved genes and new functional terms. These result derive from the\nintersection of the sets of genes and functional terms linked to each\nphenotype in PhenPath. We show here the case study of the co-\noccurrence Obesity, Ovarian Cyst and Diabetes. PhenPathTOOL\nallows to retrieve the diseases and at the genes shared among the\ninput phenotypes. Moreover, based on the enrichment analysis\nperformed with NET-GE [8], PhenPathTOOL reports the molecular\nfunctions and the biological pathways shared among the phenotypes,\nhighlighting possible explanation for their co-occurrence in the same\npatient. 8" + }, + { + "id": 143299, + "strid": "ea5465fe-bfe6-446e-9513-dcb1bfe3b791", + "image_id": 206070, + "image_name": "17319.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1417.692, + 1868.5, + 1275.0079999999998, + 141.05099999999993 + ], + "priority": 15, + "parents": [ + 143287 + ], + "children": [], + "area": 2648957.502, + "iscrowd": 0, + "segmentation": [], + "text": "PhenPath could be used to study a complex disease, as we proved\nin many study cases reported in the publication (e.g.: Rett syndrome,\nTourette syndrome)." + }, + { + "id": 143297, + "strid": "4cfbed14-443a-4e3b-ad58-771eabaf13b7", + "image_id": 206070, + "image_name": "17319.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 90.406, + 2038.312, + 2619.358, + 1414.0730000000003 + ], + "priority": 16, + "parents": [ + 143287 + ], + "children": [], + "area": 184275.63467200001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143288, + "strid": "ad2778b4-8f84-4f44-93b9-7a613ecf4e45", + "image_id": 206070, + "image_name": "17319.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1222.582, + 3494.847, + 295.70900000000006, + 40.24299999999994 + ], + "priority": 17, + "parents": [ + 143301 + ], + "children": [ + 143300 + ], + "area": 4272737.034954, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 143300, + "strid": "3af9be8f-911a-4334-a853-4e0b33d39dfe", + "image_id": 206070, + "image_name": "17319.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 27.964, + 3567.734, + 2652.497, + 144.7840000000001 + ], + "priority": 18, + "parents": [ + 143288 + ], + "children": [], + "area": 99768.11357599999, + "iscrowd": 0, + "segmentation": [], + "text": "We propose our resource for formulating hypothesis on the relations among phenotypes and underlying molecular mechanisms. We\nparticipated to the Critical Assessment of protein Function Annotation algorithms (CAFA) 4th edition. Preliminary results of the\nexperiment show that PhenPath is among the top-scoring methods for predicting the association between genes and phenotypes." + }, + { + "id": 65673, + "strid": "5d2ba8a4-eadc-48d0-ade8-c1baeac1a269", + "image_id": 203080, + "image_name": "119692.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 331.05, + 275.32, + 176.0, + 183.04000000000002 + ], + "priority": -1, + "parents": [], + "children": [ + 65650, + 65651, + 65642, + 65643, + 65644, + 65646, + 65647, + 65641, + 65652, + 65649, + 65648, + 65645 + ], + "area": 91144.686, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 65641, + "strid": "63a73c7c-fb86-4b02-b859-1826dff9a282", + "image_id": 203080, + "image_name": "119692.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 447.054, + 90.65, + 4517.374, + 135.975 + ], + "priority": 1, + "parents": [ + 65673 + ], + "children": [], + "area": 40525.4451, + "iscrowd": 0, + "segmentation": [], + "text": "Attentional Capture by Non-drug Reward is Magnified in Addiction" + }, + { + "id": 65642, + "strid": "b7ad2a1a-9835-4259-a965-7c95d2709600", + "image_id": 203080, + "image_name": "119692.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1042.32, + 238.711, + 3308.7120000000004, + 187.34299999999996 + ], + "priority": 2, + "parents": [ + 65673 + ], + "children": [], + "area": 248813.24952, + "iscrowd": 0, + "segmentation": [], + "text": "Brian A. Anderson, Monica L. Faulkner, JessicaJ. Rilee, Steven Yantis, and Cherie L. Marvel\nJohns Hopkins University" + }, + { + "id": 65643, + "strid": "a9413988-4a61-4dea-ab82-27b66bf3ecad", + "image_id": 203080, + "image_name": "119692.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 475.531, + 601.091, + 410.066, + 71.66200000000003 + ], + "priority": 3, + "parents": [ + 65673 + ], + "children": [ + 65672, + 65654, + 65653 + ], + "area": 285837.404321, + "iscrowd": 0, + "segmentation": [], + "text": "Background" + }, + { + "id": 65653, + "strid": "d4b5c82b-178c-461d-907c-5b1eb9812783", + "image_id": 203080, + "image_name": "119692.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 74.534, + 738.909, + 695.253, + 511.07399999999996 + ], + "priority": 4, + "parents": [ + 65643 + ], + "children": [], + "area": 55073.84340600001, + "iscrowd": 0, + "segmentation": [], + "text": "Stimuli associated with\ndrug reward involuntarily\ncapture-attention in drug-\ndependent populations’.\nThe magnitude of this\nattentional bias predicts\nlater relapse?*." + }, + { + "id": 65672, + "strid": "e0ca6d07-c1d9-4d6b-a466-6d0c43c95ee3", + "image_id": 203080, + "image_name": "119692.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 846.888, + 750.081, + 410.40999999999997, + 485.08000000000004 + ], + "priority": 5, + "parents": [ + 65643 + ], + "children": [], + "area": 635234.597928, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 65654, + "strid": "5b1d1b0d-5647-4578-9876-4c6e0a8aa5fa", + "image_id": 203080, + "image_name": "119692.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 74.839, + 1316.275, + 1185.337, + 783.252 + ], + "priority": 6, + "parents": [ + 65643 + ], + "children": [], + "area": 98508.704725, + "iscrowd": 0, + "segmentation": [], + "text": "Drug addiction is associated with working\nmemory impairmentsand greater\nimpulsiveness? ®.\n\nStimuli that have been associated with\nnon-drug reward through learning\ninvoluntarily capture attention in healthy\nadults (referred to as value-driven\nattentional capture), and the magnitude of\nthis capture is predicted by visualyworking\nmemory capacity and impulsiveness”." + }, + { + "id": 65645, + "strid": "8766060b-530c-4b8e-ae17-472c0bef4351", + "image_id": 203080, + "image_name": "119692.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 493.362, + 2229.72, + 375.91799999999995, + 65.51899999999978 + ], + "priority": 7, + "parents": [ + 65673 + ], + "children": [ + 65655 + ], + "area": 1100059.11864, + "iscrowd": 0, + "segmentation": [], + "text": "Hypothesis" + }, + { + "id": 65655, + "strid": "56ac825f-5533-4a47-b1ec-a7966858408b", + "image_id": 203080, + "image_name": "119692.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 72.005, + 2366.332, + 1188.3289999999997, + 361.5169999999998 + ], + "priority": 8, + "parents": [ + 65645 + ], + "children": [], + "area": 170387.73565999998, + "iscrowd": 0, + "segmentation": [], + "text": "Addiction is associated with an increased\nattentional bias fornon-drug reward relative\nto healthy controls, which is related to\nworking memory impairments and\nincreased+mpulsiveness." + }, + { + "id": 65646, + "strid": "534b41e9-569e-4374-b529-2801d694b435", + "image_id": 203080, + "image_name": "119692.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 276.818, + 2847.984, + 809.336, + 66.62199999999984 + ], + "priority": 9, + "parents": [ + 65673 + ], + "children": [ + 65656 + ], + "area": 788373.2349119999, + "iscrowd": 0, + "segmentation": [], + "text": "Overview of Experiment" + }, + { + "id": 65656, + "strid": "d8ad83dc-844b-41dd-9da5-e552e51ac958", + "image_id": 203080, + "image_name": "119692.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 79.2, + 2980.732, + 1196.315, + 507.4340000000002 + ], + "priority": 10, + "parents": [ + 65646 + ], + "children": [], + "area": 236073.9744, + "iscrowd": 0, + "segmentation": [], + "text": "Drug-dependent patients and’ageé- and sex-\nmatched controls completed>a visual search\ntask involving monetary reward that\nprovides a measure of value-driven\nattentional capture’?-Measures of visual\nworking memory.Gapacity and\nimpulsiveness Were also obtained." + }, + { + "id": 65644, + "strid": "4369b9ab-6481-4b35-9e6e-c51a0dd52402", + "image_id": 203080, + "image_name": "119692.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1801.802, + 603.401, + 414.67499999999995, + 67.07299999999998 + ], + "priority": 11, + "parents": [ + 65673 + ], + "children": [ + 65658, + 65666 + ], + "area": 1087209.128602, + "iscrowd": 0, + "segmentation": [], + "text": "Participants" + }, + { + "id": 65666, + "strid": "500b7747-44f9-401b-9e8c-b6b4ede96260", + "image_id": 203080, + "image_name": "119692.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1513.563, + 740.179, + 1002.076, + 915.41 + ], + "priority": 12, + "parents": [ + 65644 + ], + "children": [], + "area": 1120307.547777, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 65658, + "strid": "cc3cffc1-b266-47fc-94a0-9b428c3305f9", + "image_id": 203080, + "image_name": "119692.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1409.079, + 1689.787, + 1150.6810000000003, + 193.1679999999999 + ], + "priority": 13, + "parents": [ + 65644 + ], + "children": [], + "area": 2381043.376173, + "iscrowd": 0, + "segmentation": [], + "text": "Opioid-dependent patients were-recruited from\narea methadone clinics and abstained from\nmethadone on the day of testing." + }, + { + "id": 65647, + "strid": "b665758e-e29d-445c-bd56-a37ac66b5241", + "image_id": 203080, + "image_name": "119692.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1467.025, + 1965.629, + 1085.38, + 68.394 + ], + "priority": 14, + "parents": [ + 65673 + ], + "children": [ + 65667, + 65668, + 65657 + ], + "area": 2883626.883725, + "iscrowd": 0, + "segmentation": [], + "text": "Leelee Ne Cm Cte Er Sy" + }, + { + "id": 65657, + "strid": "6e551d1c-ad36-4c85-b918-aafc6ef2ab6f", + "image_id": 203080, + "image_name": "119692.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1407.518, + 2088.231, + 1152.929, + 194.9989999999998 + ], + "priority": 15, + "parents": [ + 65647 + ], + "children": [], + "area": 2939222.7206580006, + "iscrowd": 0, + "segmentation": [], + "text": "Participants completed the Barratt\nImpulsivenesssScale (BIS-11), a visual working\nmemory (WWM) task, and a visual search task." + }, + { + "id": 65667, + "strid": "bf98bcda-8498-40ae-8f80-2de07313392b", + "image_id": 203080, + "image_name": "119692.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1452.929, + 2348.206, + 1176.77, + 559.2429999999999 + ], + "priority": 16, + "parents": [ + 65647 + ], + "children": [], + "area": 3411776.5953740003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 65668, + "strid": "4e1d06ed-a5f7-4078-9ba5-4343775b0878", + "image_id": 203080, 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"priority": 19, + "parents": [ + 65648 + ], + "children": [], + "area": 2021341.5482480002, + "iscrowd": 0, + "segmentation": [], + "text": "Response time was slower on distractor\npresent trials>replicating value-driven\nattentional-capture’®. Critically, this slowing\nwas significantly greater in the patients." + }, + { + "id": 65671, + "strid": "8d10d82e-b875-4e2d-9d70-42a0ddc57c42", + "image_id": 203080, + "image_name": "119692.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2770.861, + 1072.747, + 1140.5439999999999, + 700.8720000000001 + ], + "priority": 20, + "parents": [ + 65648 + ], + "children": [], + "area": 2972432.8251670003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 65660, + "strid": "21d37fd4-d5c4-44f9-bcd8-fb9dafb75ffc", + "image_id": 203080, + "image_name": "119692.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2757.5, + 1905.064, + 1169.9210000000003, + 139.90100000000007 + ], + "priority": 21, + "parents": [ + 65648 + ], + "children": [], + "area": 5253213.98, + "iscrowd": 0, + "segmentation": [], + "text": "Patients were more impulsive than controls\nand had a reduced visual WM capacity:" + }, + { + "id": 65670, + "strid": "bd5ce2ae-4093-4bf9-9e86-931fe2b30d60", + "image_id": 203080, + "image_name": "119692.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2732.399, + 2102.677, + 1199.7069999999999, + 475.13200000000006 + ], + "priority": 22, + "parents": [ + 65648 + ], + "children": [], + "area": 5745352.532123, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 65659, + "strid": "02a7a3de-125f-42fb-8e5b-b4b1e9d5960f", + "image_id": 203080, + "image_name": "119692.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2752.087, + 2756.802, + 1106.659, + 142.4920000000002 + ], + "priority": 23, + "parents": [ + 65648 + ], + "children": [], + "area": 7586958.945774, + "iscrowd": 0, + "segmentation": [], + "text": "Visual WM capacity predicted attentional\ncapture specifically in the patients." + }, + { + "id": 65669, + "strid": "b4cc6be7-548e-4278-9185-ec07ca089f71", + "image_id": 203080, + "image_name": "119692.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2732.57, + 3006.565, + 1214.5790000000002, + 400.2159999999999 + ], + "priority": 24, + "parents": [ + 65648 + ], + "children": [], + "area": 8215649.322050001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 65649, + "strid": "8d32f7d8-00c2-459b-b76e-be0b7d7b93c0", + "image_id": 203080, + "image_name": "119692.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4480.381, + 603.874, + 417.2039999999997, + 68.077 + ], + "priority": 25, + "parents": [ + 65673 + ], + "children": [ + 65662 + ], + "area": 2705585.5959940003, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 65662, + "strid": "10570013-84d7-4979-99d1-5391c9485f8d", + "image_id": 203080, + "image_name": "119692.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4057.37, + 756.195, + 1249.5789999999997, + 486.371 + ], + "priority": 26, + "parents": [ + 65649 + ], + "children": [], + "area": 3068162.9071500003, + "iscrowd": 0, + "segmentation": [], + "text": "Addiction is associated with increased(attentional\nbias for non-drug (monetary) reward.\n\nThis increased attentional bias. is\\reflected in\nreduced visual WM capacity and*increased\nimpulsiveness.\n\nDrug-related attentionalbiases may reflect a general\nsensitivity to reward’s,influence on attention." + }, + { + "id": 65650, + "strid": "908d66a8-19d7-459b-821d-bcf60e11e8a5", + "image_id": 203080, + "image_name": "119692.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4395.054, + 1376.993, + 586.0100000000002, + 55.375 + ], + "priority": 27, + "parents": [ + 65673 + ], + "children": [ + 65663 + ], + "area": 6051958.592622, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 65663, + "strid": "95bf91bf-f6e8-44c0-9840-88b9f1611c57", + "image_id": 203080, + "image_name": "119692.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4082.766, + 1527.716, + 1194.6240000000003, + 574.815 + ], + "priority": 28, + "parents": [ + 65650 + ], + "children": [], + "area": 6237306.942456, + "iscrowd": 0, + "segmentation": [], + "text": "Relationship between value-driven attentional.capture\nand risky reward-seeking behaviors in addiction\n\nNéural mechanisms of addiction-related.susceptibility\nto value-driven attentional capture\n\nRelationship between value-driven attentional capture\nand treatment relapse\n\nAssociation between addiction and attention to\npunishment-related stimuli" + }, + { + "id": 65651, + "strid": "a1de5b09-6a2f-4333-86ed-0cb11b331d37", + "image_id": 203080, + "image_name": "119692.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4472.186, + 2240.349, + 441.3040000000001, + 68.86799999999994 + ], + "priority": 29, + "parents": [ + 65673 + ], + "children": [ + 65664 + ], + "area": 10019257.432914, + "iscrowd": 0, + "segmentation": [], + "text": "A CAT ets]" + }, + { + "id": 65664, + "strid": "4f71389f-849d-48ae-be32-aa0e432f2a28", + "image_id": 203080, + "image_name": "119692.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4054.713, + 2374.501, + 1207.7679999999996, + 211.04300000000012 + ], + "priority": 30, + "parents": [ + 65651 + ], + "children": [], + "area": 9627920.073213002, + "iscrowd": 0, + "segmentation": [], + "text": "Anderson, B.A., Faulkner, M. L., Rilee, J. J., Yantis, S., &\nMarvel,.@.°E. (in press). Attentional bias for non-drug reward\nis magnified in addiction. Experimental and Clinical\nPsychopharmacology." + }, + { + "id": 65652, + "strid": "74b71e16-c31d-46c5-bfe7-8501feeaa725", + "image_id": 203080, + "image_name": "119692.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4497.408, + 2679.998, + 381.4359999999997, + 53.52300000000014 + ], + "priority": 31, + "parents": [ + 65673 + ], + "children": [ + 65665 + ], + "area": 12053044.445184002, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 65665, + "strid": "47a1359e-432e-497b-a95f-4d0ef766789a", + "image_id": 203080, + "image_name": "119692.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 4039.952, + 2793.311, + 1136.2730000000001, + 436.5920000000001 + ], + "priority": 32, + "parents": [ + 65652 + ], + "children": [], + "area": 11284842.361072002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 21817, + "strid": "5726c63f-0846-4064-903b-0e761fc121ff", + "image_id": 201368, + "image_name": "117011.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 483.84, + 29.32, + 410.26000000000005, + 170.11 + ], + "priority": -1, + "parents": [], + "children": [ + 21789, + 21785, + 21786, + 21779, + 21784, + 21787, + 21780, + 21781, + 21788, + 21782, + 21783 + ], + "area": 14186.1888, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 21779, + "strid": "af45db8e-7f3a-461f-a5c6-cec659e1b289", + "image_id": 201368, + "image_name": "117011.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 1066.369, + 65.927, + 2466.308, + 65.01299999999999 + ], + "priority": 1, + "parents": [ + 21817 + ], + "children": [], + "area": 70302.509063, + "iscrowd": 0, + "segmentation": [], + "text": "Efficacy of Clevidipine in Controlling Perioperative Hypertension in Neurosurgical Patients" + }, + { + "id": 21780, + "strid": "68fb6955-5c50-4a7b-a60a-fc3058b123b8", + "image_id": 201368, + "image_name": "117011.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 839.424, + 266.935, + 2921.547, + 116.51299999999998 + ], + "priority": 2, + "parents": [ + 21817 + ], + "children": [], + "area": 224071.64544, + "iscrowd": 0, + "segmentation": [], + "text": "Sorosch Didehvar MD, Sunmi Kim MD, Beatriz Nistal-Nuno MD, Alice Chu MD, Hyelin Kim, Michael Haile MD, Alex Bekker MD, PhD\nDepartment of Anesthesiology, New York University Medical Center, New York, NY, United States" + }, + { + "id": 21781, + "strid": "45fd1864-6eb0-4daf-aa1f-318046dc7582", + "image_id": 201368, + "image_name": "117011.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 413.218, + 471.188, + 144.52000000000004, + 33.30500000000001 + ], + "priority": 3, + "parents": [ + 21817 + ], + "children": [ + 21792, + 21791, + 21793, + 21790 + ], + "area": 194703.362984, + "iscrowd": 0, + "segmentation": [], + "text": "Abstract" + }, + { + "id": 21790, + "strid": "bf8d89b3-115b-405a-ad48-065562ff6de5", + "image_id": 201368, + "image_name": "117011.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 100.832, + 556.425, + 767.319, + 332.813 + ], + "priority": 4, + "parents": [ + 21781 + ], + "children": [], + "area": 56105.44559999999, + "iscrowd": 0, + "segmentation": [], + "text": "Background:\n\nAcute blood pressure (BP) elevations in neurosurgical patients\nare associated with serious neurologic, cardiovascular, or\nsurgical site complications. Clevidipine, an ultra-short-acting\ndihydropyridine calcium antagonist, has been shown to be\nefficacious and safe for acute hypertension in cardiac surgery.\nThis study assessed the efficacy and safety of clevidipine in\ncontrolling perioperative hypertension in the neurosurgical\nsetting." + }, + { + "id": 21791, + "strid": "7deb8a16-4479-4c45-9a93-a4b9d72786b6", + "image_id": 201368, + "image_name": "117011.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 97.429, + 927.751, + 781.589, + 443.4269999999999 + ], + "priority": 5, + "parents": [ + 21781 + ], + "children": [], + "area": 90389.852179, + "iscrowd": 0, + "segmentation": [], + "text": "Methods:\n\nThis study was a prospective, open-label, observational trial.\nIRB approval was obtained and patients scheduled for\nintracranial surgery were prospectively enrolled after giving\nconsent. Clevidipine (0.5 mg/ml in 20% lipid solution, which\nwas to be initiated at 10 mg/h and titrated to effect) was\nadministered as the primary antihypertensive agent for\nperioperative hypertension, with target BPs of <130 mmHg.\nOther vasoactive drugs were administered as needed for\ntreating systolic BP (SBP) <90 mmHg or >130 mmHg. The\nprimary end point was the proportion of patients not requiring\nrescue antihypertensive to maintain target SBP (<130 mmHg)." + }, + { + "id": 21792, + "strid": "e834d17b-a52d-410e-91eb-f40b6c565963", + "image_id": 201368, + "image_name": "117011.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 101.641, + 1410.193, + 768.874, + 436.25400000000013 + ], + "priority": 6, + "parents": [ + 21781 + ], + "children": [], + "area": 143333.426713, + "iscrowd": 0, + "segmentation": [], + "text": "Results:\n\nTwenty-two patients were enrolled. One patient did not\nrequire antihypertensive therapy. Seventeen patients (17 of\n21, 81%) were treated with clevidipine alone; one received\nclevidipine in the postanesthesia care unit only. Twenty-eight\nhypertensive episodes (defined as any new acute BP elevation\nrequiring clevidipine initiation) were documented. SBP was\nreduced to target level within 15 minutes in 22 of 28 episodes\n(78.6%). Two mild hypotensive episodes occurred after the\ninitiation of clevidipine infusion; these transient decreases in\nBP were treated with vasoactive drugs and resolved within 5\nminutes." + }, + { + "id": 21793, + "strid": "3e06c9f6-c170-4a3b-8e5d-4d07b1a41578", + "image_id": 201368, + "image_name": "117011.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 99.697, + 1890.162, + 775.761, + 187.19299999999998 + ], + "priority": 7, + "parents": [ + 21781 + ], + "children": [], + "area": 188443.480914, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions:\n\nClevidipine is effective and safe for perioperative hypertension\nin patients undergoing intracranial procedures. Rapid control\nof BP is possible with higher starting doses. Drug effects\nresolved rapidly after drug discontinuation." + }, + { + "id": 21782, + "strid": "dceea0e0-5cf0-4a82-801d-d1e9dae9e335", + "image_id": 201368, + "image_name": "117011.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1267.653, + 471.441, + 202.952, + 39.00600000000003 + ], + "priority": 8, + "parents": [ + 21817 + ], + "children": [ + 21796, + 21795, + 21794 + ], + "area": 597623.597973, + "iscrowd": 0, + "segmentation": [], + "text": "Background" + }, + { + "id": 21794, + "strid": "bf1bd712-62bd-454e-b5b8-b65246a28fdf", + "image_id": 201368, + "image_name": "117011.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 986.249, + 555.065, + 748.6879999999999, + 289.337 + ], + "priority": 9, + "parents": [ + 21782 + ], + "children": [], + "area": 547432.3011850001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 21795, + "strid": "4d31603b-1e19-4870-9494-c9937ae6262c", + "image_id": 201368, + "image_name": "117011.png", + 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Riesgo de muerte materna de acuerdo con el lugar de residencia" + }, + { + "id": 118340, + "strid": "c6ae9c26-ba45-4187-8e2b-13b945387924", + "image_id": 205104, + "image_name": "14191.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 457.947, + 906.275, + 268.5690000000001, + 22.442999999999984 + ], + "priority": 15, + "parents": [ + 118348 + ], + "children": [ + 118341 + ], + "area": 415025.917425, + "iscrowd": 0, + "segmentation": [], + "text": "REFERENCIAS BIBLIOGRAFICAS" + }, + { + "id": 118341, + "strid": "215d96bc-1782-4764-b553-30a4f2f8747e", + "image_id": 205104, + "image_name": "14191.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 456.794, + 944.483, + 384.31499999999994, + 142.61699999999996 + ], + "priority": 16, + "parents": [ + 118340 + ], + "children": [], + "area": 431434.16750199994, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 100565, + "strid": "af150d57-185c-41f1-874f-581c88665d86", + "image_id": 204389, + "image_name": "122036.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 163.62, + 7.56, + 33.579999999999984, + 35.89 + ], + "priority": -1, + "parents": [], + "children": [ + 100542, + 100544, + 100536, + 100543, + 100539, + 100537, + 100538, + 100540, + 100541 + ], + "area": 1236.9672, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 100536, + "strid": "d351f947-2b41-499c-b8fc-d7b3471e9ab5", + "image_id": 204389, + "image_name": "122036.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 206.72, + 8.746, + 716.865, + 32.871 + ], + "priority": 1, + "parents": [ + 100565 + ], + "children": [], + "area": 1807.97312, + "iscrowd": 0, + "segmentation": [], + "text": "Angry expression hampers face recognition decision" + }, + { + "id": 100537, + "strid": "cf50aab5-b035-456d-b48d-0f01bcc46e6c", + "image_id": 204389, + "image_name": "122036.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 254.817, + 44.457, + 620.869, + 66.53900000000002 + ], + "priority": 2, + "parents": [ + 100565 + ], + "children": [], + "area": 11328.399369, + "iscrowd": 0, + "segmentation": [], + "text": "Wenfeng Chen, Ke Tong, Wei Tang, Huiyun Li, Naixin Ren, and Xiaolan Fu\nInstitute of Psychology, Chinese Academy of Sciences\nE-mail: chenwf@psych.ac.cn, fuxl@psych.ac.cn" + }, + { + "id": 100538, + "strid": "b38211bb-9b00-408a-8a0a-5b8476fad5fb", + "image_id": 204389, + "image_name": "122036.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 55.142, + 119.879, + 91.607, + 14.584999999999994 + ], + "priority": 3, + "parents": [ + 100565 + ], + "children": [ + 100545 + ], + "area": 6610.367818000001, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 100545, + "strid": "cc6a316c-dd96-4c37-973c-9f7337c025c9", + "image_id": 204389, + "image_name": "122036.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 34.819, + 140.781, + 529.289, + 269.846 + ], + "priority": 4, + "parents": [ + 100538 + ], + "children": [], + "area": 4901.853639000001, + "iscrowd": 0, + "segmentation": [], + "text": "‘It 18 Known that facial expressions can largely modulate the encoding and consolidation of face memory\n(D’Angembeau & Van der Linden, 2007, 2011; Liu et al, 2014; Righi etal, 2012). Is also evident that face\nmemory is less often associated with “remember” responses when a studied face is with an angry, rather than a\nhappy, expression (D’Argembeau et al, 2003). In addition, negative stimuli are more likely to be classified as\nold (ie., a liberal bias), whereas positive stimuli are prone to be classified as new (ie, a conservative bias)\n(Maratos et al., 001; Sergerie wet al, 2007; Windmann & Kutas, 2001). However, memory retrieval varies as\n1 function of encoding-retrieval match (Ritchey et al, 2013; Tulving, & Thomson, 1973). There are at least two\nkinds of stimulus associations contributing to the reactivation based on encoding: retrieval correspondence: the\nperceptual and emotional associations (Danker, & Anderson, 2010). Depending on research methods, the\ncontributions from each are not always identifiable. In most studies, the learned faces were shown with\nemotional expressions and the test faces with the identical or neutral expression. This makes it difficult to\nestimate the extent fo which the retrieval performance depended on perceptual association (image similarity) or\nemotional association (emotional similarity). Thus, the effect of expression at retrieval is often neglected.\n\n‘The present study investigated the effect of facial expression atthe stage of retrieval and whether any effect\nof his has to rely on emotional/physical association between the learning and test face stimuli, Apart from the\nbaseline conditions, where the face stimuli at learning and test were identical, the facial expression used at\nlearning formed no emotional association with the face stimuli at test in our experiments. We investigated\nwhether seeing an emotional expression atthe tst session alfets retrieval of the faces studied with a neutral\nexpression." + }, + { + "id": 100539, + "strid": "98dc463d-61e0-4ed7-8e06-ac273556340c", + "image_id": 204389, + "image_name": "122036.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 71.418, + 426.52, + 61.007000000000005, + 14.916999999999973 + ], + "priority": 5, + "parents": [ + 100565 + ], + "children": [ + 100546 + ], + "area": 30461.20536, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 100546, + "strid": "be0d33db-c76a-4bca-987f-9672c9c73758", + "image_id": 204389, + "image_name": "122036.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 32.098, + 453.858, + 541.211, + 103.95099999999996 + ], + "priority": 6, + "parents": [ + 100539 + ], + "children": [], + "area": 14567.934084, + "iscrowd": 0, + "segmentation": [], + "text": "216 Chinese models im 6 experimental blocks were used, and cacti Glock consisted of one learning session\nwith 18 neutral faces as learning faces and one test session with 18 target faces and 18 lute faces a8 test faces.\nTest faces were shown with neutral, angry, or happy expressions.\n\nParticipants were instructed to judge whether each face identity had been previously presented (old/new\njudgment). When participants recognized a face as an old one, they were asked to further indicate whether they\nwere able to vividly “Remember” the face, or simply “Know” the face because it looked familiar, or whether they\nwere simply making a “Guess”. The three options were referred to as a RKG judgment." + }, + { + "id": 100540, + "strid": "e0354c42-3214-4ffe-8db6-9be5b9448b26", + "image_id": 204389, + "image_name": "122036.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 67.628, + 569.869, + 67.91000000000001, + 14.340000000000032 + ], + "priority": 7, + "parents": [ + 100565 + ], + "children": [ + 100547, + 100561, + 100548, + 100562, + 100560 + ], + "area": 38539.100732, + "iscrowd": 0, + "segmentation": [], + "text": "Results-1" + }, + { + "id": 100560, + "strid": "6ea3b098-efad-40a7-a437-e1e3d906d640", + "image_id": 204389, + "image_name": "122036.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 33.805, + 594.737, + 267.344, + 84.86900000000003 + ], + "priority": 8, + "parents": [ + 100540 + ], + "children": [ + 100554 + ], + "area": 20105.084284999997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 100554, + "strid": "d2e1fb67-7d9e-45b1-a2ce-47a2dc6f9507", + "image_id": 204389, 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+ "text": "Figure € Drift Difiuston Model (Ratchtt\n& McKoon, 2008)" + }, + { + "id": 100564, + "strid": "ec1d82a1-c73d-4ac0-886e-cd29b60083d4", + "image_id": 204389, + "image_name": "122036.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 598.252, + 259.06, + 188.99700000000007, + 91.149 + ], + "priority": 20, + "parents": [ + 100541 + ], + "children": [ + 100558 + ], + "area": 154983.16311999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 100558, + "strid": "83fb6738-bb76-4b9a-b9bf-b155e99ff06e", + "image_id": 204389, + "image_name": "122036.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 594.934, + 349.874, + 240.11400000000003, + 10.377999999999986 + ], + "priority": 21, + "parents": [ + 100564 + ], + "children": [], + "area": 208151.938316, + "iscrowd": 0, + "segmentation": [], + "text": "figure >. DIM parameters as a function of test expression" + }, + { + "id": 100549, + "strid": "ac3fba83-810b-4caf-a158-048184682ee3", + "image_id": 204389, + "image_name": "122036.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 783.812, + 127.481, + 343.1619999999999, + 42.43799999999999 + ], + "priority": 22, + "parents": [ + 100541 + ], + "children": [], + "area": 99921.13757199999, + "iscrowd": 0, + "segmentation": [], + "text": "Diffusion model maps different cognitive processes to different\npsychologically meaningful parameters and has been applied in memory\ntasks (e.g, McKoon & Ratcliff, 2012):" + }, + { + "id": 100552, + "strid": "29a7f1be-2256-41ac-9dc5-371fe7544e6d", + "image_id": 204389, + "image_name": "122036.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 783.894, + 170.748, + 346.72399999999993, + 82.80700000000002 + ], + "priority": 23, + "parents": [ + 100541 + ], + "children": [], + "area": 133848.332712, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 100550, + "strid": "0819718d-1fa8-4884-adb4-96b178ff55aa", + "image_id": 204389, + "image_name": "122036.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 796.736, + 264.757, + 328.1350000000001, + 73.85899999999998 + ], + "priority": 24, + "parents": [ + 100541 + ], + "children": [], + "area": 210941.433152, + "iscrowd": 0, + "segmentation": [], + "text": "v: The speed for angry test faces was smallest, confirming the\npattern of d° and correct RT performance.\n\n7, More old responses for neutral faces, but comparable for angry\nand happy test faces.\n\na and ty: No significant differences." + }, + { + "id": 100542, + "strid": "200fb101-3344-496a-b530-89a560732a46", + "image_id": 204389, + "image_name": "122036.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 628.898, + 371.441, + 77.28300000000002, + 15.040999999999997 + ], + "priority": 25, + "parents": [ + 100565 + ], + "children": [ + 100553 + ], + "area": 233598.502018, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion" + }, + { + "id": 100553, + "strid": "9e4bda3f-b421-49e2-99a7-376c7b9b71d1", + "image_id": 204389, + "image_name": "122036.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 601.75, + 393.04, + 527.8780000000002, + 241.43099999999998 + ], + "priority": 26, + "parents": [ + 100542 + ], + "children": [], + "area": 236511.82, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 100543, + "strid": "6ed99375-ba5d-4c34-88bb-7cf0e186b158", + "image_id": 204389, + "image_name": "122036.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 627.968, + 639.821, + 79.06399999999996, + 14.744000000000028 + ], + "priority": 27, + "parents": [ + 100565 + ], + "children": [ + 100559 + ], + "area": 401787.11372799997, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion" + }, + { + "id": 100559, + "strid": "536eba66-b93a-4b18-8a38-b1f81af5e8a2", + "image_id": 204389, + "image_name": "122036.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 600.951, + 658.124, + 528.365, + 59.697 + ], + "priority": 28, + "parents": [ + 100543 + ], + "children": [], + "area": 395500.275924, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 100544, + "strid": "50f86d9e-b038-4863-8006-776354be2a8e", + "image_id": 204389, + "image_name": "122036.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 626.781, + 725.04, + 81.30200000000002, + 16.835000000000036 + ], + "priority": 29, + "parents": [ + 100565 + ], + "children": [ + 100551 + ], + "area": 454441.29623999994, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 100551, + "strid": "d507c486-9893-4743-ab9b-e0d2599dfa74", + "image_id": 204389, + "image_name": "122036.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 600.937, + 742.766, + 462.94500000000005, + 64.01699999999994 + ], + "priority": 30, + "parents": [ + 100544 + ], + "children": [], + "area": 446355.571742, + "iscrowd": 0, + "segmentation": [], + "text": "D' Argembenu, A., Vin der Linden, M., Combi, C, & Etenne, A. M. (2003). Cognition and Emotion, 17, 609-622,\nLi, Chen, W, Wars, J.(2018). Frontiers Paohoooy, 1438\n\nRac, & MeKon, (2008). Nera Computation 20, $73.92\n\nwhe, C2, & Roldan: A. (2014), dearuat of Biqurdmentel Popcholegy: Leoreing, Menery, and Cognition, &0{2), 305-208." + }, + { + "id": 101103, + "strid": "a89d38f5-072d-4782-a271-76094d1448c0", + "image_id": 204406, + "image_name": "122061.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 28.65, + 372, + 234.67, + 301.72 + ], + "priority": -1, + "parents": [], + "children": [ + 101098, + 101080, + 101101, + 101092, + 101075, + 101076, + 101078, + 101095, + 101079, + 101102, + 101091, + 101090 + ], + "area": 10657.8, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 101075, + "strid": "c126593a-9ab1-431a-b3dd-ef5d530aa7e5", + "image_id": 204406, + "image_name": "122061.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 90.002, + 195.418, + 5247.539, + 127.85399999999998 + ], + "priority": 1, + "parents": [ + 101103 + ], + "children": [], + "area": 17588.010836, + "iscrowd": 0, + "segmentation": [], + "text": "Are we overthinking It? Haptic perception of geographic slant is accurate when embedded within a secondary task." + }, + { + "id": 101076, + "strid": "78e8a3b8-c0fa-4681-8e91-f9e370ce3723", + "image_id": 204406, + "image_name": "122061.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 186.541, + 366.322, + 3690.507, + 178.96699999999998 + ], + "priority": 2, + "parents": [ + 101103 + ], + "children": [], + "area": 68334.072202, + "iscrowd": 0, + "segmentation": [], + "text": "Jonathan K. Doyon', Alen Hajnal', Jeffrey B. Wagman2, Michael McGathy', Joseph D. Clark’, Zsolt Palatinus'\n\n'Department of Psychology, University of Southern Mississippi, 7Depariment of Psychology, Illinois State University" + }, + { + "id": 101080, + "strid": "cfab6162-b8ab-4d83-aa1d-820b11b03c0e", + "image_id": 204406, + "image_name": "122061.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 148.226, + 718.652, + 973.959, + 60.400999999999954 + ], + "priority": 3, + "parents": [ + 101103 + ], + "children": [ + 101077 + ], + "area": 106522.91135200001, + "iscrowd": 0, + "segmentation": [], + "text": "Affordance Perception & Perceptual Equivalence" + }, + { + "id": 101077, + "strid": "59b232c0-a2d6-435c-836e-bf0e079f695a", + "image_id": 204406, + "image_name": "122061.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 140.676, + 845.116, + 1238.211, + 824.845 + ], + "priority": 4, + "parents": [ + 101080 + ], + "children": [], + "area": 118887.53841599998, + "iscrowd": 0, + "segmentation": [], + "text": "Gibson (1966) claimed that perceptual systems are\nequivalent. Hajnal, Wagman, Bunch, & Doyon (2014) found\ndifferences between visual and haptic perception of\ngeographic slant. Haptic pedal perception underestimates\nphysical capabilities when the surface being judged is not\nvisible.\n\nHeft (1993) found improved performance in reaching when it\nwas embedded within the context of a cognitive task. The\ncurrent experiment adapts this idea in order to improve the\naccuracy of haptic perception of the affordance for stand-on-\nability (Kinsella-Shaw, Shaw, & Turvey, 1992) by embedding it\nin an affordance task of reaching." + }, + { + "id": 101079, + "strid": "f4ad8830-86cb-4a91-ad38-e299c8991f04", + "image_id": 204406, + "image_name": "122061.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 157.664, + 1860.6, + 147.226, + 54.738000000000056 + ], + "priority": 5, + "parents": [ + 101103 + ], + "children": [ + 101082, + 101085, + 101083, + 101081, + 101084 + ], + "area": 293349.63839999994, + "iscrowd": 0, + "segmentation": [], + "text": "Design" + }, + { + "id": 101081, + "strid": "a5415139-5750-413e-aa12-7b43876e490e", + "image_id": 204406, + "image_name": "122061.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 150.679, + 1991.976, + 1229.511, + 174.69700000000012 + ], + "priority": 6, + "parents": [ + 101079 + ], + "children": [], + "area": 300148.951704, + "iscrowd": 0, + "segmentation": [], + "text": "Participants perceived whether they could reach up to screw a\nlightbulb into a socket hanging from the ceiling while intending\nto step on a sloped ramp (Figure 1)." + }, + { + "id": 101082, + "strid": "1985730e-eef7-448f-a9dc-fe32f39c9c6b", + "image_id": 204406, + "image_name": "122061.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 173.686, + 2184.52, + 1108.106, + 360.703 + ], + "priority": 7, + "parents": [ + 101079 + ], + "children": [], + "area": 379420.54072, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 101083, + "strid": "692f268b-83e1-4252-b36d-8f80a76de4bc", + "image_id": 204406, + "image_name": "122061.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 150.939, + 2618.339, + 1221.841, + 625.5439999999999 + ], + "priority": 8, + "parents": [ + 101079 + ], + "children": [], + "area": 395209.470321, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 101084, + "strid": 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Experimental Setup" + }, + { + "id": 101102, + "strid": "9d18ee81-66e4-4624-8f3f-f8df6b5dce99", + "image_id": 204406, + "image_name": "122061.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3138.07, + 1841.13, + 354.9549999999999, + 52.455999999999904 + ], + "priority": 21, + "parents": [ + 101103 + ], + "children": [ + 101100 + ], + "area": 5777594.819100001, + "iscrowd": 0, + "segmentation": [], + "text": "Confidence Data" + }, + { + "id": 101100, + "strid": "90a8aec3-c10f-44f6-a52e-6a16a656273e", + "image_id": 204406, + "image_name": "122061.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3183.532, + 1953.037, + 1365.6149999999998, + 552.5409999999999 + ], + "priority": 22, + "parents": [ + 101102 + ], + "children": [], + "area": 6217555.786684001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 101101, + "strid": "1315287c-27c6-448b-a9e5-071afa4de60f", + "image_id": 204406, + "image_name": "122061.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3213.257, + 2650.707, + 258.78499999999985, + 57.70199999999977 + ], + "priority": 23, + "parents": [ + 101103 + ], + "children": [ + 101099 + ], + "area": 8517402.822699, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 101099, + "strid": "590a5c0d-0de5-41b8-b544-eb7e6b86e95e", + "image_id": 204406, + "image_name": "122061.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3202.766, + 2759.117, + 1349.8790000000004, + 1218.737 + ], + "priority": 24, + "parents": [ + 101101 + ], + "children": [], + "area": 8836806.117622001, + "iscrowd": 0, + "segmentation": [], + "text": "The affordance for stand-on-ability corresponds to the action\nboundary when embedded within another task (reaching). Haptic\nperception of stand-on-ability showed lowest confidence and\nlongest response times at an angle that approximates the\naction boundary.\n\nHaptic pedal perception is not typically the focus of visual\nattention, nor is stand-on-ability. When haptic perception occurs\nwithout visual reference, judgmenis tend to be more conservative\nand underestimate action capabilities. Conservative haptic\njudgments likely serve an adaptive role helping to avoid injurious\nor fatal falls.\n\nThese results are consistent with Stoffregen & Bardy’s notion of a\nglobal array (2001). The senses may not be separate divisions\neach with its unique energy array. Rather, the senses collectively\nsample from a single, global energy array.\n\nPerhaps studying affordances in a unimodal context produces\ninaccuracies and/or distortions in perceptual judgments. It is best\nto study stand-on-ability and other such affordances within the\ncontext of other affordance tasks." + }, + { + "id": 101095, + "strid": "41fd5483-eb16-414a-9681-7ee9842a8d70", + "image_id": 204406, + "image_name": "122061.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4722.753, + 1840.64, + 435.10199999999986, + 53.625999999999976 + ], + "priority": 25, + "parents": [ + 101103 + ], + "children": [ + 101096 + ], + "area": 8692888.08192, + "iscrowd": 0, + "segmentation": [], + "text": "Response Time Data" + }, + { + "id": 101096, + "strid": "8ed833fd-ab6f-4f98-bbca-a6731d25fc0e", + "image_id": 204406, + "image_name": "122061.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 4766.223, + 1952.535, + 1427.705, + 609.3860000000002 + ], + "priority": 26, + "parents": [ + 101095 + ], + "children": [], + "area": 9306217.225305, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 101098, + "strid": "d4310206-b08e-40b8-be29-5f7857d4a645", + "image_id": 204406, + "image_name": "122061.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4801.529, + 3106.43, + 234.91100000000006, + 44.909000000000106 + ], + "priority": 27, + "parents": [ + 101103 + ], + "children": [ + 101097 + ], + "area": 14915613.73147, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 101097, + "strid": "7b8231ba-11f6-4efe-8a7f-ef01a3c047ea", + "image_id": 204406, + "image_name": "122061.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4789.438, + 3204.885, + 1324.8279999999995, + 715.096 + ], + "priority": 28, + "parents": [ + 101098 + ], + "children": [], + "area": 15349598.004630001, + "iscrowd": 0, + "segmentation": [], + "text": "Gibson, J. J. (1966). The senses considered as perceptual systems. Boston:\nHoughton Mifflin.\n\nHajnal, A., Wagman, J., Bunch, D., & Doyon, J. (2014). Do Geographical\nSlants Feel Steeper Than They Look?. Journal of Vision, 14(10), 1357-1357.\n\nHeft, H. (1993). A methodological note on overestimates of reaching\ndistance: Distinguishing between perceptual and analytical judgments.\nEcological Psychology, 5(3), 255-271.\n\nKinsella-Shaw, J. M., Shaw, B., & Turvey, M. T. (1992). Perceiving 'Walk-on-\nable' Slopes. Ecological Psychology, 4(4), 223-239.\n\nStoffregen, T. A., & Bardy, B. G. (2001). Specification in the global array.\nBehavioral and Brain Sciences, 24(02), 246-254." + }, + { + "id": 29971, + "strid": "3e6257cf-b8b4-4fbc-bf57-99b4f943b235", + "image_id": 201680, + "image_name": "117501.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 511.38, + 78.18, + 161.91999999999996, + 133.76999999999998 + ], + "priority": -1, + "parents": [], + "children": [ + 29959, + 29962, + 29954, + 29940, + 29964, + 29958, + 29943, + 29955, + 29942, + 29941, + 29939 + ], + "area": 39979.68840000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 29939, + "strid": "d8573d8f-90dc-44ff-8197-bf0afa2a26a0", + "image_id": 201680, + "image_name": "117501.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 777.617, + 158.123, + 4407.942, + 137.18400000000003 + ], + "priority": 1, + "parents": [ + 29971 + ], + "children": [], + "area": 122959.13289099999, + "iscrowd": 0, + "segmentation": [], + "text": "A unified framework for multiple alternative detection in birds and primates" + }, + { + "id": 29940, + "strid": "f9aaf39d-41f2-492a-97fa-d59f5d9bd903", + "image_id": 201680, + "image_name": "117501.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1459.928, + 335.018, + 3061.3720000000003, + 227.43699999999995 + ], + "priority": 2, + "parents": [ + 29971 + ], + "children": [], + "area": 489102.158704, + "iscrowd": 0, + "segmentation": [], + "text": "Devarajan Sridharan, Nicholas Steinmetz, Tirin Moore, Eric Knudsen\nDepartment of Neurobiology, Stanford University School of Medicine" + }, + { + "id": 29964, + "strid": "00e60648-3a9d-48e5-a503-80f4fb35d7c7", + "image_id": 201680, + "image_name": "117501.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 538.601, + 762.903, + 491.3359999999999, + 93.26300000000003 + ], + "priority": 3, + "parents": [ + 29971 + ], + "children": [ + 29963 + ], + "area": 410900.318703, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 29963, + "strid": "41f951b1-6c3e-4847-aaa0-6495bf2071c4", + "image_id": 201680, + "image_name": "117501.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 258.812, + 910.758, + 1048.6390000000001, + 1273.8349999999998 + ], + "priority": 4, + "parents": [ + 29964 + ], + "children": [], + "area": 235715.099496, + "iscrowd": 0, + "segmentation": [], + "text": "Studies of spatial vision and attention seek\nto measure sensitivity to visual stimuli at\nmultiple locations within a single\nexperimental session.\n\nA key analytical challenge is to decouple\nthe effects of perceptual sensitivity from\nthose of choice bias at each location.\n\nSignal detection theory (SDT) is a powerful\napproach for decoupling perceptual\nsensitivity from choice bias in 2-AFC and\nYes/No tasks.\n\nSDT cannot be readily applied to tasks with\nmore than two choices.\n\nHere we introduce a theoretical model that\nextends SDT to multialternative detection\ntasks." + }, + { + "id": 29959, + "strid": "4b15ac59-7709-42bb-ae6c-ab8bba39ecc5", + "image_id": 201680, + "image_name": "117501.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 575.193, + 2613.849, + 372.596, + 89.846 + ], + "priority": 5, + "parents": [ + 29971 + ], + "children": [ + 29960 + ], + "area": 1503467.6478570001, + "iscrowd": 0, + "segmentation": [], + "text": "Summary" + }, + { + "id": 29960, + "strid": "f86302a5-7049-4769-80b2-ab5e86f84686", + "image_id": 201680, + "image_name": "117501.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 239.592, + 2769.757, + 1080.792, + 895.8160000000003 + ], + "priority": 6, + "parents": [ + 29959 + ], + "children": [], + "area": 663611.619144, + "iscrowd": 0, + "segmentation": [], + "text": "A single model accounts for spatial detection\nbehaviors in diverse tasks.\n\nThe model demonstrated remarkable predictive\npower: with parameters estimated from only\n\n8 out of 25 response probabilities (4 miss and\n\n4 false-alarm rates) the remaining 17\nprobabilities were predicted accurately.\n\nThis multidimensional SDT model is relevant for\nassessing the effects of neural manipulations\non sensitivity and bias, respectively, in\nmultialternative tasks of spatial vision and\nattention." + }, + { + "id": 29962, + "strid": "89c099a3-3b0f-42de-8efc-f226d94a52e0", + "image_id": 201680, + "image_name": "117501.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 577.904, + 3740.342, + 410.246, + 52.965999999999894 + ], + "priority": 7, + "parents": [ + 29971 + ], + "children": [ + 29961 + ], + "area": 2161558.603168, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgments" + }, + { + "id": 29961, + "strid": "681e960c-681c-4490-96c2-b7a5e7e1e874", + "image_id": 201680, + "image_name": "117501.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 287.158, + 3813.555, + 972.449, + 113.6289999999999 + ], + "priority": 8, + "parents": [ + 29962 + ], + "children": [], + "area": 1095092.82669, + "iscrowd": 0, + "segmentation": [], + "text": "Stanford SoM Dean's Postdoctoral Fellowship (DS), Stanford MBC IGERT\nFellowship and NSF Graduate Research Fellowship (NS),\nNIH EY014924 (TM), NIH MH094938-01A1 (EK)" + }, + { + "id": 29941, + "strid": "ec720dda-f459-4bf6-a406-a1d0b3682fca", + "image_id": 201680, + "image_name": "117501.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1683.755, + 696.029, + 1231.047, + 90.25300000000004 + ], + "priority": 9, + "parents": [ + 29971 + ], + "children": [ + 29966, + 29968, + 29965, + 29967 + ], + "area": 1171942.308895, + "iscrowd": 0, + "segmentation": [], + "text": "Multialternative detection task" + }, + { + "id": 29965, + "strid": "f15e3592-ceef-4114-9f50-fcc7992b1113", + "image_id": 201680, + "image_name": "117501.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1721.447, + 851.616, + 1201.044, + 138.75700000000006 + ], + "priority": 10, + "parents": [ + 29941 + ], + "children": [], + "area": 1466011.8083519998, + "iscrowd": 0, + "segmentation": [], + "text": "Subject detects target and responds to its location (Go),\nor withholds response (NoGo) if no target is detected (catch)" + }, + { + "id": 29966, + "strid": "ea66177a-5861-41c4-9308-ba98be117274", + "image_id": 201680, + "image_name": "117501.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1801.062, + 1017.669, + 966.75, + 655.1150000000001 + ], + "priority": 11, + "parents": [ + 29941 + ], + "children": [], + "area": 1832884.9644779998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 29967, + "strid": "cb7b6f35-1a41-42f8-b820-8d9080bd359d", + "image_id": 201680, + "image_name": "117501.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1771.491, + 1727.377, + 1003.145, + 120.55899999999997 + ], + "priority": 12, + "parents": [ + 29941 + ], + "children": [], + "area": 3060032.809107, + "iscrowd": 0, + "segmentation": [], + "text": "Decision cannot be modeled with\nindependent, one-dimensional (Yes/No) models" + }, + { + "id": 29968, + "strid": "f4bf747e-084a-43e9-ab1f-212add12ed8c", + "image_id": 201680, + "image_name": "117501.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1826.083, + 1859.31, + 918.9810000000002, + 536.8299999999999 + ], + "priority": 13, + "parents": [ + 29941 + ], + "children": [], + "area": 3395254.38273, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 29942, + "strid": "251b2602-8717-4d9f-8a78-960a9bf9690f", + "image_id": 201680, + "image_name": "117501.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3207.22, + 703.249, + 1108.3030000000003, + 86.64300000000003 + ], + "priority": 14, + "parents": [ + 29971 + ], + "children": [ + 29970, + 29969 + ], + "area": 2255474.25778, + "iscrowd": 0, + "segmentation": [], + "text": "Multidimensional! SDT model" + }, + { + "id": 29970, + "strid": "61d12a8c-c87c-4ce0-9cc9-7918f1764f95", + "image_id": 201680, + "image_name": "117501.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3275.07, + 815.221, + 848.4649999999997, + 787.048 + ], + "priority": 15, + "parents": [ + 29942 + ], + "children": [], + "area": 2669905.84047, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 29969, + "strid": "b07c4b12-874f-4191-9169-6fdd3646a7b4", + "image_id": 201680, + "image_name": "117501.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 3336.488, + 1675.059, + 932.6290000000004, + 664.2140000000002 + ], + "priority": 16, + "parents": [ + 29942 + ], + "children": [], + "area": 5588814.252792, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 29943, + "strid": "f7cabfd3-142f-49fd-b805-bf44f3b7f613", + "image_id": 201680, + "image_name": "117501.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4592.397, + 695.292, + 1186.1779999999999, + 82.88499999999999 + ], + "priority": 17, + "parents": [ + 29971 + ], + "children": [ + 29952, + 29947, + 29950, + 29948, + 29946, + 29949, + 29944, + 29951, + 29945 + ], + "area": 3193056.894924, + "iscrowd": 0, + "segmentation": [], + "text": "Estimating sensitivity and bias" + }, + { + "id": 29944, + "strid": "e220cf41-a20f-4e6d-b643-ab218e69f134", + "image_id": 201680, + "image_name": "117501.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4675.282, + 861.062, + 873.0569999999998, + 121.56499999999994 + ], + "priority": 18, + "parents": [ + 29943 + ], + "children": [], + "area": 4025707.669484, + "iscrowd": 0, + "segmentation": [], + "text": "Markov Chain Monte Carlo or MLE\nfor parameter estimation" + }, + { + "id": 29945, + "strid": "5fe1176e-1dbf-4f83-af30-c4726c113e91", + "image_id": 201680, + "image_name": "117501.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 4686.333, + 989.995, + 324.1729999999998, + 349.95899999999995 + ], + 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"image_name": "117501.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4809.74, + 1765.431, + 655.7129999999997, + 58.94100000000003 + ], + "priority": 22, + "parents": [ + 29943 + ], + "children": [], + "area": 8491264.09794, + "iscrowd": 0, + "segmentation": [], + "text": "Estimated parameters are unique" + }, + { + "id": 29949, + "strid": "c888b5b9-e14e-4ebe-a8a2-6982fdb9d159", + "image_id": 201680, + "image_name": "117501.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 4789.479, + 1864.893, + 232.07800000000043, + 224.71100000000024 + ], + "priority": 23, + "parents": [ + 29943 + ], + "children": [], + "area": 8931865.860747, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 29950, + "strid": "d805ebb0-a27d-4440-865a-286fc6ca5441", + "image_id": 201680, + "image_name": "117501.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 4791.321, + 2100.656, + 244.97199999999975, + 233.92000000000007 + ], + "priority": 24, + "parents": [ + 29943 + ], + "children": [], + "area": 10064917.206575999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 29951, + "strid": "64d9ba63-8ea0-4148-ab24-1ae2e5d9d447", + "image_id": 201680, + "image_name": "117501.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 5044.675, + 1862.3, + 604.2529999999997, + 221.77899999999977 + ], + "priority": 25, + "parents": [ + 29943 + ], + "children": [], + "area": 9394698.2525, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 29952, + "strid": "cb4b5bfd-38d3-4633-b754-4ef28daa28e4", + "image_id": 201680, + "image_name": "117501.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 5103.879, + 2096.295, + 499.0020000000004, + 272.5250000000001 + ], + "priority": 26, + "parents": [ + 29943 + ], + "children": [], + "area": 10699236.028305, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 29958, + "strid": "4b0ded59-d023-45bf-9a66-909510518648", + "image_id": 201680, + "image_name": 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"parents": [ + 29971 + ], + "children": [ + 29956 + ], + "area": 8053255.7243369995, + "iscrowd": 0, + "segmentation": [], + "text": "Change detection (orientation):\nMonkey" + }, + { + "id": 29956, + "strid": "73a0572b-a3d2-4637-8b4f-950f74eb190e", + "image_id": 201680, + "image_name": "117501.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3080.306, + 2804.11, + 1268.4119999999998, + 1144.2130000000002 + ], + "priority": 30, + "parents": [ + 29955 + ], + "children": [], + "area": 8637516.857660001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 29954, + "strid": "ac5725c9-e843-4008-932d-6ef226e5ac9e", + "image_id": 201680, + "image_name": "117501.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4597.114, + 2576.853, + 1099.29, + 195.54700000000003 + ], + "priority": 31, + "parents": [ + 29971 + ], + "children": [ + 29953 + ], + "area": 11846087.002241999, + "iscrowd": 0, + "segmentation": [], + "text": "Spatial cueing (orientation):\nMonkey" + }, + { + "id": 29953, + "strid": "b31bcef6-23b5-400a-b80a-6bb29a4bc0ff", + "image_id": 201680, + "image_name": "117501.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 4612.97, + 2830.535, + 1096.6480000000001, + 1149.498 + ], + "priority": 32, + "parents": [ + 29954 + ], + "children": [], + "area": 13057173.03895, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178351, + "strid": "da009919-0e4f-415c-9a98-1b645b7f233d", + "image_id": 207460, + "image_name": "8209.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 96.29, + 133.99, + 118.27, + 354.82 + ], + "priority": -1, + "parents": [], + "children": [ + 178335, + 178332, + 178331, + 178334, + 178336, + 178333, + 178337 + ], + "area": 12901.897100000002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178331, + "strid": "b70b63b4-83cf-48be-8a88-fefe128db32d", + "image_id": 207460, + "image_name": "8209.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 373.988, + 401.12, + 2667.367, + 95.894 + ], + "priority": 1, + "parents": [ + 178351 + ], + "children": [], + "area": 150014.06656, + "iscrowd": 0, + "segmentation": [], + "text": "Analysis of Data from Experimental qPCR Systems with RK Ward" + }, + { + "id": 178332, + "strid": "7ca46de7-b2fa-47ba-adb9-123270fadf0a", + "image_id": 207460, + "image_name": "8209.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1159.508, + 513.542, + 1292.907, + 185.65499999999997 + ], + "priority": 2, + "parents": [ + 178351 + ], + "children": [], + "area": 595456.057336, + "iscrowd": 0, + "segmentation": [], + "text": "S. Rédiger '?3, A. Bohm |, J. Nitschke ', P. Schierack', W. Lehmann ?, |. Schimke 3, Ch. Schréder '\n\n' Lausitz University of Applied Sciences, Senftenberg, Germany, stefan.roediger@hs-lausitz.de\n2 Attomol GmbH, Germany\n3 Charité, Germany" + }, + { + "id": 178333, + "strid": "25b62b9c-f2b1-45e3-8723-0ce45a639fbb", + "image_id": 207460, + "image_name": "8209.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 369.864, + 760.447, + 315.319, + 43.942999999999984 + ], + "priority": 3, + "parents": [ + 178351 + ], + "children": [ + 178341 + ], + "area": 281261.969208, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 178341, + "strid": "bb460a22-4c8c-4f5b-b276-d2339117837c", + "image_id": 207460, + "image_name": "8209.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 318.993, + 819.171, + 1376.935, + 740.549 + ], + "priority": 4, + "parents": [ + 178333 + ], + "children": [], + "area": 261309.81480300002, + "iscrowd": 0, + "segmentation": [], + "text": "Real-time quantitative PCR (qPCR) is a well established method for the\nprecise quantification of nucleic acids. However, there is an ongoing\ndevelopment of novel device concepts for qPCRs, hybridization and\nmelting curve analysis. This includes lab-on-chip systems or the recently\npublished microbead-based VideoScan platform [1]. Besides dedicated\nhardware an easy to use software for data analysis is also a requirement\nduring developmental processes. Experimental instruments usually collect\ndata of different formats and quality. Analysis software must therefore be\nable to preprocess data of different origins. Preprocessing includes data\nimport, removal of missing values, selection of data ranges, outlier\nremoval, detection of background signal, data transformation and\nsmoothing /normalization of data. Subsequently, the software must be able\nto analyze and quantify both, the amplification and melting curve data. To\nautomate this process we developed a set of plugins for the open source\nsoftware RK Ward [1]." + }, + { + "id": 178334, + "strid": "19cf589a-4955-4fdf-8a9e-94a6605a4dba", + "image_id": 207460, + "image_name": "8209.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1800.595, + 761.258, + 218.202, + 41.72799999999995 + ], + "priority": 5, + "parents": [ + 178351 + ], + "children": [ + 178342 + ], + "area": 1370717.3485100002, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 178342, + "strid": "f2f9f7fd-7fa1-408a-b668-f49ed59a9c26", + "image_id": 207460, + "image_name": "8209.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1749.822, + 820.042, + 1380.008, + 641.5849999999999 + ], + "priority": 6, + "parents": [ + 178334 + ], + "children": [], + "area": 1434927.532524, + "iscrowd": 0, + "segmentation": [], + "text": "Data from qPCR experiments were taken from the recently published\nVideoScan platform [1] or the gpcR package [4]. All data were exported as\nCSV and imported to RK Ward for further processing. RK Ward is a GUI\n(Graphical User Interface) and an Integrated Development Environment\n(IDE) for statistical analysis with R. Statistical procedures and plots were\nimplemented using the easy to extend RK Ward plugin architecture based\non ECMAScript, XML, and R [2,3] (Fig. 1). The software is licensed under\nthe terms of the GNU General Public License Version 2 (or later). Plugins\npresented here rely on the excellent qpcR package [4] for qPCR\nquantification, algorithms from the MBmca package [5] for melting curve\nanalysis and auxiliary R packages for hybridization assays. The plugins are\nenhanced by a set of functions from the stats and robustbase packages for\ndata preprocessing (Fig. 2)." + }, + { + "id": 178335, + "strid": "c271aabe-76a2-4104-8b52-102e5fab823b", + "image_id": 207460, + "image_name": "8209.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 350.86, + 1578.964, + 178.70299999999997, + 45.07300000000009 + ], + "priority": 7, + "parents": [ + 178351 + ], + "children": [ + 178347, + 178350, + 178340, + 178349, + 178348 + ], + "area": 553995.30904, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 178340, + "strid": "6a1d5f7f-8d45-4ed1-aeb1-37c1b8ad45e3", + "image_id": 207460, + "image_name": "8209.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 312.868, + 1638.931, + 2816.496, + 244.9090000000001 + ], + "priority": 8, + "parents": [ + 178335 + ], + "children": [], + "area": 512769.064108, + "iscrowd": 0, + "segmentation": [], + "text": "RK Ward is a GUI and an IDE for statistical analysis with R which provides tools to manage and edit different types of data objects. Statistical\nprocedures and plots were implemented using the easily extendable RK Ward plugin architecture based on ECMAScript, XML, and R [2]. The plugins\nare enhanced by a set of functions for data preprocessing. The data are processed interactively as defined by the user (Fig. 2). A simple algorithm for the\ndetection of the background range was implemented for qPCR analysis (Fig. 3). The RK Ward-qPCR-plugin can be used to impute missing values and to\nperform a simple background correction by robust linear regression (Fig. 4)." + }, + { + "id": 178347, + "strid": "d74afe94-3c9a-4d81-b7e0-e2f57cb1b330", + "image_id": 207460, + "image_name": "8209.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 354.48, + 2028.928, + 627.059, + 702.113 + ], + "priority": 9, + "parents": [ + 178335 + ], + "children": [ + 178343 + ], + "area": 719214.3974400001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178343, + "strid": "12bcda0b-506f-46f0-a93f-932dcc872ec1", + "image_id": 207460, + "image_name": "8209.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 308.591, + 2798.28, + 693.956, + 643.7269999999999 + ], + "priority": 10, + "parents": [ + 178347 + ], + "children": [], + "area": 863524.0234800001, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 1 Plugin structure of RKWard.\nPlugins provide complete GUI dialogs, or re-\nusable GUI components, which accept user\nsettings and translate those user settings into\nR. Thus, the plugin framework is basically a\ntool set used to define GUIs for the\nautomatic generation of R code. One or more\nplugins are declared in an XML file called\n“plugin map” with an unique identifier. For\nmost plugins, the plugin map defines the\nplacement in the menu hierarchy. Plugin\nmaps are meant to represent groups of\nplugins. Each plugin is defined by two XML\nfiles, and one ECMAScript file. The\nECMAScript file contains R code which calls\nfunctions from further packages gpcR [4]." + }, + { + "id": 178348, + "strid": "387a4d47-1ece-4c59-b20d-80487848dd19", + "image_id": 207460, + "image_name": "8209.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1007.309, + 1915.958, + 728.0539999999999, + 864.7779999999998 + ], + "priority": 11, + "parents": [ + 178335 + ], + "children": [ + 178344 + ], + "area": 1929961.7370220001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178344, + "strid": "d42e9845-a726-4441-8933-c25634c1f89b", + "image_id": 207460, + "image_name": "8209.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1026.887, + 2799.497, + 687.9089999999999, + 763.0170000000003 + ], + "priority": 12, + "parents": [ + 178348 + ], + "children": [], + "area": 2874767.075839, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 2 Graphical user interface and\noutput of results. (Top) Screen shot of the\ngraphical user to set parameters (e.g.,\ntrimming of data, calculation of background).\nThe RKWard-qPCR-plugin provides default\nvalues which support the user during data\nanalysis. The plugin was successfully tested\nwith data sets of the gpcR package and data\nfrom the VideoScan platform. (Bottom) The\noutput of the plugin based on HTML\nQincluding tables, parameters, etc.) and\nimages (SVG, PNG or JPEG) as journal\nformat. The HTML output can be directly\nretrieved from a dedicated folder or pasted\ninto office applications as richly formatted\ntext. In addition editing R objects of type\ndata.frame (e.g., smoothed data, output of\nqPCR analysis) generated from the plugins is\npossible in RK Ward." + }, + { + "id": 178349, + "strid": "752016ee-61c5-4301-a524-6289d597263c", + "image_id": 207460, + "image_name": "8209.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1753.883, + 2129.345, + 676.6429999999998, + 493.53099999999995 + ], + "priority": 13, + "parents": [ + 178335 + ], + "children": [ + 178345 + ], + "area": 3734621.9966349998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178345, + "strid": "fba48169-906f-4228-9a17-869efa55535b", + "image_id": 207460, + "image_name": "8209.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1749.107, + 2800.149, + 685.5920000000001, + 674.6619999999998 + ], + "priority": 14, + "parents": [ + 178349 + ], + "children": [], + "area": 4897760.2169429995, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 3 Detection of background range in\nqPCR amplification data of MLC-2v. The\nalgorithm (bg.max()) is based on the\nassumption that the signal difference of\nsuccessive cycles in the linear ground phase\nis approximately constant. After transition in\nthe early exponential phase the AMFI\nchanges drastically. First data are smoothed\nby Friedman's ‘super smoother’. Thereof the\napproximate 1% (FD) and 2\"4 (FD2) derivative\nare calculated. The difference of cycles at the\nmaxima of the 1% and 2™ approximate\nderivative and a correction factor are used to\nestimate the range before the exponential\nphase. This simple function reliable finds the\nbackground range without modeling the\nfunction." + }, + { + "id": 178350, + "strid": "f3b39d57-f189-4487-8b5e-0347e1dcc981", + "image_id": 207460, + "image_name": "8209.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2455.841, + 1878.183, + 710.2400000000002, + 894.614 + ], + "priority": 15, + "parents": [ + 178335 + ], + "children": [ + 178346 + ], + "area": 4612518.816903, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178346, + "strid": "bc3bbd2f-9fff-4340-b6bc-8b0bbe75e7ac", + "image_id": 207460, + "image_name": "8209.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2472.447, + 2796.797, + 685.277, + 806.817 + ], + "priority": 16, + "parents": [ + 178350 + ], + "children": [], + "area": 6914932.352259001, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 4 Preprocessing and analysis of\nexperimental data. (a) Raw data from a\nVideoScan qPCR experiment. Fragments of\nhuman genes (HRPT1, MLC-2v, VIM) were\namplified and the fluorescence (refMFI) per\ncycle determined on the surface of\nmicrobeads using an experimental\nmicorbead-based qPCR system (not shown).\nThe experiment contained data of non-\namplified products (-e-), data with different\nbackground (-e-, -e-), noise and missing\nvalues (NA) (-e-). The approximately linear\ndecrease of refMFI values was due to\nphotobleaching of the fluorescence dyes. (b)\nData were smoothed and missing values\nwere imputed. The background, different\nslopes and noise is eliminated by robust\nlinear regression. The normalized curves\n(normed refMFl) are visually easer to\ncompare." + }, + { + "id": 178336, + "strid": "61d4915f-7a78-4934-93a3-1175cfc8d40b", + "image_id": 207460, + "image_name": "8209.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 354.847, + 3621.376, + 670.3010000000002, + 42.29300000000012 + ], + "priority": 17, + "parents": [ + 178351 + ], + "children": [ + 178339 + ], + "area": 1285034.409472, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion and Conclusion" + }, + { + "id": 178339, + "strid": "ec9164db-f6bf-4f64-88dd-e6473f9c2567", + "image_id": 207460, + "image_name": "8209.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 318.18, + 3680.54, + 2807.958, + 292.74699999999984 + ], + "priority": 18, + "parents": [ + 178336 + ], + "children": [], + "area": 1171074.2172, + "iscrowd": 0, + "segmentation": [], + "text": "Novel technologies provide scientist with a high degree of freedom to adapt a system to specific requirements. RK Ward provides all tools of R for an\ninteractive data analysis and presentation, a dedicated output file and an output window for documenting results and figures. RK Ward does not impose\nartificial limitations on how users can work with the application. For example, the user is not limited to using only one data.frame or one model at a\ntime. The software aims to accelerate the development process and to enable easier collaboration between colleagues in the hardware and wetware\ndisciplines. The plugins presented here are currently in beta stage and available upon request. In future the plugins will be provided for downloading as\ncontributed “plugin Packs\"." + }, + { + "id": 178337, + "strid": "23a47b82-2f8e-4882-8e43-390be2d23ad9", + "image_id": 207460, + "image_name": "8209.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 351.687, + 3998.975, + 467.25200000000007, + 54.46199999999999 + ], + "priority": 19, + "parents": [ + 178351 + ], + "children": [ + 178338 + ], + "area": 1406387.520825, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgments" + }, + { + "id": 178338, + "strid": "18154a31-0b6d-4527-9a92-6db15980330e", + "image_id": 207460, + "image_name": "8209.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 320.885, + 4053.294, + 2809.1309999999994, + 199.38500000000022 + ], + "priority": 20, + "parents": [ + 178337 + ], + "children": [], + "area": 1300641.24519, + "iscrowd": 0, + "segmentation": [], + "text": "RKWard is currently developed by T. Friedrichsmeier (lead developer), P. Kapat, M. Michalke, and S. Rédiger. Many more people have contributed in\nvarious forms. We would like to thank A. d’Hardemare, D. Medri, D. Sibai, D. Steuer, G. M. Mejia, |. Soumpasis, J. Vajen, M. Martin, P. Grosjean, P.\nEcochard, R. Tautenhahn, R. Vollgraf, R. Qu, Y. Jacolin, and many more people on rkward-devel@lists.sourceforge.net for their contributions. Grateful\nthanks belong also to the authors of the cited R packages, the R community. This work was in part funded by the BMBF InnoProfile-Projekt 03 IP 611." + }, + { + "id": 94664, + "strid": "7c19b4bc-1351-4736-b084-7c0693573b9e", + "image_id": 204162, + "image_name": "121555.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 1539.97, + 975.03, + 270.43000000000006, + 197.62000000000012 + ], + "priority": -1, + "parents": [], + "children": [ + 94635, + 94637, + 94634, + 94632, + 94636, + 94633, + 94631 + ], + "area": 1501516.9491, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 94631, + "strid": "d072d313-3c6e-47ac-acd3-1339e30b317b", + "image_id": 204162, + "image_name": "121555.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 85.856, + 92.314, + 1604.033, + 700.563 + ], + "priority": 1, + "parents": [ + 94664 + ], + "children": [], + "area": 7925.710783999999, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 94632, + "strid": "55043195-8390-4708-b000-277b219a88d6", + "image_id": 204162, + "image_name": "121555.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 604.958, + 976.909, + 754.09, + 292.04599999999994 + ], + "priority": 2, + "parents": [ + 94664 + ], + "children": [], + "area": 590988.914822, + "iscrowd": 0, + "segmentation": [], + "text": "- Jan Freiwald, PhD\nReef Check Foundation\nReet fa al Tl fey ge]\nAe eee org *" + }, + { + "id": 94633, + "strid": "ed694c96-018e-4103-95eb-703d86ae567c", + "image_id": 204162, + "image_name": "121555.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 166.458, + 1408.529, + 1537.992, + 92.4079999999999 + ], + "priority": 3, + "parents": [ + 94664 + ], + "children": [ + 94644, + 94643, + 94653, + 94648, + 94654, + 94638 + ], + "area": 234460.920282, + "iscrowd": 0, + "segmentation": [], + "text": "Citizen Science Ecosystem Monitoring" + }, + { + "id": 94638, + "strid": "91755380-7b88-4aa5-8370-73a8ca87a7b0", + "image_id": 204162, + "image_name": "121555.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 199.271, + 1547.423, + 415.775, + 208.74099999999999 + ], + "priority": 4, + "parents": [ + 94633 + ], + "children": [], + "area": 308356.528633, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 94653, + "strid": "dbb64409-8f97-4fc8-9680-25c3e1a27e7c", + "image_id": 204162, + "image_name": "121555.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 646.738, + 1527.931, + 976.904, + 272.5050000000001 + ], + "priority": 5, + "parents": [ + 94633 + ], + "children": [], + "area": 988171.0390780001, + "iscrowd": 0, + "segmentation": [], + "text": "Ecosystem-based management (EBM) has become\nan essential aspect of marine conservation and\nresource management in California. This has greatly\nincreased the need for long-term ecological\nmonitoring data to implement management" + }, + { + "id": 94654, + "strid": "68ead6bc-ee43-48f0-b63e-00f7eea086d9", + "image_id": 204162, + "image_name": "121555.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 169.366, + 1811.533, + 1462.32, + 719.9270000000001 + ], + "priority": 6, + "parents": [ + 94633 + ], + "children": [], + "area": 306812.098078, + "iscrowd": 0, + "segmentation": [], + "text": "approaches, assess outcomes and adapt strategies accordingly. One pertinent\nexample of EBM is the implementation of a California-wide network of marine\nprotected areas (MPAs). Management agencies are mandated to monitor the\nperformance of these MPAs with respect to meeting their goals and manage\nthem adaptively based on the monitoring results. Common goals of MPAs are\nprotecting biodiversity and restoring marine life populations.\n\nCitizen science can address these data needs while involving the public in\nconservation science. Well trained volunteers can collect scientifically valid\ndata. In California, Reef Check trains experienced recreation scuba divers as\ncitizen scientists to conduct visual surveys of fish, invertebrates and algae\nspecies in one of the west coast’s most iconic ecosystems targeted for\nprotection by MPAs: rocky reefs and kelp forests." + }, + { + "id": 94644, + "strid": "e4e829e6-0e69-49c7-8fcd-ab5201912991", + "image_id": 204162, + "image_name": "121555.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 233.632, + 2599.104, + 666.758, + 393.06899999999996 + ], + "priority": 7, + "parents": [ + 94633 + ], + "children": [], + "area": 607233.865728, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 94648, + "strid": "ebe9a45e-df4b-443d-b7f3-0bdffeadd1dc", + "image_id": 204162, + "image_name": "121555.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 237.383, + 2992.629, + 510.48299999999995, + 65.79300000000012 + ], + "priority": 8, + "parents": [ + 94633 + ], + "children": [], + "area": 710399.249907, + "iscrowd": 0, + "segmentation": [], + "text": "Reef Check site in northern California:\ndivers returning from survey" + }, + { + "id": 94643, + "strid": "9908be9a-a109-430e-bb78-f2ad33cedce9", + "image_id": 204162, + "image_name": "121555.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 999.248, + 2598.852, + 585.056, + 389.1390000000001 + ], + "priority": 9, + "parents": [ + 94633 + ], + "children": [ + 94649 + ], + "area": 2596897.663296, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 94649, + "strid": "d7fb2ded-7e6b-4f19-a29a-843719894804", + "image_id": 204162, + "image_name": "121555.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1005.57, + 2991.938, + 544.59, + 66.19300000000021 + ], + "priority": 10, + "parents": [ + 94643 + ], + "children": [], + "area": 3008603.0946600004, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. Layout of survey transects ona\nrocky reef." + }, + { + "id": 94635, + "strid": "5bdca7df-34a3-4d67-abb2-5616b1d468ca", + "image_id": 204162, + "image_name": "121555.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 170.799, + 3092.006, + 843.442, + 92.89399999999978 + ], + "priority": 11, + "parents": [ + 94664 + ], + "children": [ + 94645, + 94656, + 94657, + 94655 + ], + "area": 528111.532794, + "iscrowd": 0, + "segmentation": [], + "text": "Methods and training" + }, + { + "id": 94645, + "strid": "c6e30d77-6988-4933-91c3-f25d03004529", + "image_id": 204162, + "image_name": "121555.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 163.972, + 3220.858, + 465.0880000000001, + 214.58500000000004 + ], + "priority": 12, + "parents": [ + 94635 + ], + "children": [], + "area": 528130.5279760001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 94655, + "strid": "78077f89-0433-47a1-b778-fefa2f1c97b7", + "image_id": 204162, + "image_name": "121555.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 636.699, + 3210.12, + 993.225, + 269.2669999999998 + ], + "priority": 13, + "parents": [ + 94635 + ], + "children": [], + "area": 2043880.1938799997, + "iscrowd": 0, + "segmentation": [], + "text": "Survey Methods\nReef Check surveys consist of visual transects along\n\neighteen 30 meter-long lines laid out parallel to shore\nover the rocky reef (Figure 1). Within a 2 meter-wide\nswath along the transects, a buddy pair of divers" + }, + { + "id": 94656, + "strid": "86ff8002-024c-4bca-b932-ddf6eb0e8474", + "image_id": 204162, + "image_name": "121555.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 155.527, + 3489.527, + 1457.526, + 156.8499999999999 + ], + "priority": 14, + "parents": [ + 94635 + ], + "children": [], + "area": 542715.665729, + "iscrowd": 0, + "segmentation": [], + "text": "counts and sizes fish (35 species), invertebrates (33 species) and algae (8\nspecies) during several passes along the transect tape. They also characterize\nthe physical substrate in terms of substrate type and relief." + }, + { + "id": 94657, + "strid": "01d4cf94-0076-4035-b6ba-485e42cadb34", + "image_id": 204162, + "image_name": "121555.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 155.673, + 3713.153, + 1436.553, + 493.6470000000004 + ], + "priority": 15, + "parents": [ + 94635 + ], + "children": [], + "area": 578037.666969, + "iscrowd": 0, + "segmentation": [], + "text": "Training\nVolunteers go through a four-day training. They learn about marine ecology,\nhow to identify key species of fish, invertebrates and algae and the scientific\nmethods for conducting surveys. Trainings include classroom lectures,\ntraining in a pool and six ocean dives with survey gear (Figure 2). Citizen\nscientists are tested in species identification and survey methods for each\ntype of survey they will conduct. Only after passing the theoretical and field\ntests will they be allowed to collect data. Volunteers are recertified annually\nafter their initial training." + }, + { + "id": 94634, + "strid": "93449b08-a7ea-405c-afd6-cf0903e44ec0", + "image_id": 204162, + "image_name": "121555.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1823.356, + 1408.655, + 1156.6670000000001, + 90.77999999999997 + ], + "priority": 16, + "parents": [ + 94664 + ], + "children": [ + 94642, + 94641, + 94640, + 94639, + 94662, + 94663 + ], + "area": 2568479.54618, + "iscrowd": 0, + "segmentation": [], + "text": "Monitoring California's MPAs" + }, + { + "id": 94639, + "strid": "f2626c5f-14c9-40c9-9ae5-c6a00eb1d72b", + "image_id": 204162, + "image_name": "121555.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1824.295, + 1486.555, + 364.7159999999999, + 157.64300000000003 + ], + "priority": 17, + "parents": [ + 94634 + ], + "children": [], + "area": 2711914.8537250003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 94662, + "strid": "11a40952-a45c-4d77-bacc-6f393e2de8c3", + "image_id": 204162, + "image_name": "121555.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2225.016, + 1531.266, + 496.7220000000002, + 96.16399999999999 + ], + "priority": 18, + "parents": [ + 94634 + ], + "children": [], + "area": 3407091.350256, + "iscrowd": 0, + "segmentation": [], + "text": "Reef Check California has\nconducted state mandated" + }, + { + "id": 94663, + "strid": "3f8e9ecd-febc-44a4-868c-c5e7c17bd676", + "image_id": 204162, + "image_name": "121555.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1822.504, + 1645.542, + 920.2429999999999, + 831.1770000000001 + ], + "priority": 19, + "parents": [ + 94634 + ], + "children": [], + "area": 2999006.8771679997, + "iscrowd": 0, + "segmentation": [], + "text": "wirA Monitoring since 2007 in all regions where\nMPAs were implemented throughout the state.\nThrough this program, citizen scientists have\ncontributed to the baseline data collection for\nMPAs along the entire California coast (Figure 3).\nThis level of citizen scientist involvement in\nsubtidal ecosystem monitoring is unprecedented\nin California and demonstrates how citizens can\nperform ecosystem monitoring in challenging\nenvironments.\n\nReef Check’s long-term monitoring of California\nMPAs involves stakeholders in the management\nof their resources and builds a science-based\n\nstewardship ethic in the ocean user community." + }, + { + "id": 94640, + "strid": "3e203a6c-c223-494d-92ec-82ba86e4a655", + "image_id": 204162, + "image_name": "121555.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2802.87, + 1501.331, + 672.9569999999999, + 917.825 + ], + "priority": 20, + "parents": [ + 94634 + ], + "children": [ + 94652 + ], + "area": 4208035.619969999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 94652, + "strid": "ac711d16-5998-4ba7-8511-93b3d693b57c", + "image_id": 204162, + "image_name": "121555.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2813.42, + 2440.08, + 636.7640000000001, + 101.11400000000003 + ], + "priority": 21, + "parents": [ + 94640 + ], + "children": [], + "area": 6864969.8736, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3. Reef Check California's monitoring\nsites inside and out of MPAs. A total of about 70\nsites are monitored annually." + }, + { + "id": 94642, + "strid": "d6380dd0-61fe-4eda-8074-4fa5660e267c", + "image_id": 204162, + "image_name": "121555.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1919.869, + 2598.846, + 527.3190000000002, + 386.08899999999994 + ], + "priority": 22, + "parents": [ + 94634 + ], + "children": [ + 94650 + ], + "area": 4989443.871174, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 94650, + "strid": "15c878ff-d010-4888-9685-4fdd6450a916", + "image_id": 204162, + "image_name": "121555.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1916.65, + 2993.697, + 518.6370000000002, + 95.61999999999989 + ], + "priority": 23, + "parents": [ + 94642 + ], + "children": [], + "area": 5737869.35505, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2. Diver with Reef Check survey\ngear: transect tape and slate to record\ndata" + }, + { + "id": 94641, + "strid": "573a95b8-2587-4966-8f9b-6e8d49a28e1f", + "image_id": 204162, + "image_name": "121555.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2640.494, + 2597.168, + 535.8969999999999, + 399.02700000000004 + ], + "priority": 24, + "parents": [ + 94634 + ], + "children": [ + 94651 + ], + "area": 6857806.520992001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 94651, + "strid": "06a28c2b-a439-4bbd-931a-f6d9dc45dce2", + "image_id": 204162, + "image_name": "121555.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2641.338, + 3006.939, + 483.9830000000002, + 97.42099999999982 + ], + "priority": 25, + "parents": [ + 94641 + ], + "children": [], + "area": 7942342.2443820005, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 4. Reef Check data displayed\nonline in interactive Google Earth\ninterface" + }, + { + "id": 94636, + "strid": "f6ee0890-99b2-411f-b84e-a535a191dca2", + "image_id": 204162, + "image_name": "121555.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1790.871, + 3102.724, + 186.21000000000004, + 73.24299999999994 + ], + "priority": 26, + "parents": [ + 94664 + ], + "children": [ + 94660, + 94661, + 94646 + ], + "area": 5556578.432604001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 94646, + "strid": "c63b595e-0135-41b3-9413-26ab8aae6b71", + "image_id": 204162, + "image_name": "121555.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1793.2, + 3155.83, + 377.3610000000001, + 212.46399999999994 + ], + "priority": 27, + "parents": [ + 94636 + ], + "children": [], + "area": 5659034.356, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 94660, + "strid": "2f6e4763-4073-45d6-989a-5932115246d8", + "image_id": 204162, + "image_name": "121555.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2184.478, + 3206.633, + 1242.804, + 153.23399999999992 + ], + "priority": 28, + "parents": [ + 94636 + ], + "children": [], + "area": 7004819.242574, + "iscrowd": 0, + "segmentation": [], + "text": "Citizen scientists discuss data after dives to detect potential\nmisidentifications. Then data are checked by staff and entered into\nReef Check’s online database where automated data checks are" + }, + { + "id": 94661, + "strid": "e0b02e9c-2f87-4602-b8e8-5f02cec296dc", + "image_id": 204162, + "image_name": "121555.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1789.792, + 3375.079, + 1532.87, + 160.20100000000002 + ], + "priority": 29, + "parents": [ + 94636 + ], + "children": [], + "area": 6040689.393568, + "iscrowd": 0, + "segmentation": [], + "text": "performed. Once data are finalized, they are made publically available at\ndata.reefcheck.org ina Google Earth-based interface for viewing and downloading\n(Figure 4)." + }, + { + "id": 94637, + "strid": "ff95d991-749c-4c69-a13c-34d7de78b3bc", + "image_id": 204162, + "image_name": "121555.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1788.455, + 3587.516, + 505.35300000000007, + 78.27399999999989 + ], + "priority": 30, + "parents": [ + 94664 + ], + "children": [ + 94658, + 94659, + 94647 + ], + "area": 6416110.92778, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 94647, + "strid": "9fd3dd7d-7a6e-468d-8cd0-6bb2c946cdd7", + "image_id": 204162, + "image_name": "121555.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1785.697, + 3713.391, + 385.02499999999986, + 232.16100000000006 + ], + "priority": 31, + "parents": [ + 94637 + ], + "children": [], + "area": 6630991.168527, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 94658, + "strid": "64a226e1-1b2c-4f18-987e-2cb95fc9c5cb", + "image_id": 204162, + "image_name": "121555.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2177.448, + 3739.406, + 1246.745, + 215.27100000000019 + ], + "priority": 32, + "parents": [ + 94637 + ], + "children": [], + "area": 8142362.115888, + "iscrowd": 0, + "segmentation": [], + "text": "Reef Check California has trained over 1200 citizen scientists and\nabout 250 volunteers participate in trainings and surveys annually.\n\nThese citizen scientists have collected the geographically largest" + }, + { + "id": 94659, + "strid": "74e26c73-fbe1-4f74-9ac6-75f0534a40ac", + "image_id": 204162, + "image_name": "121555.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1787.457, + 3965.757, + 1675.325, + 433.4119999999998 + ], + "priority": 33, + "parents": [ + 94637 + ], + "children": [], + "area": 7088620.109949, + "iscrowd": 0, + "segmentation": [], + "text": "ecological dataset on California's kelp forests with survey sites ranging from San Diego in\nthe south to Humboldt County in the north. They have conducted over 500 surveys at a\ntotal of 84 sites and are now in the tenth year of data collection.\n\nThese data have been used as a benchmark for California's MPAs at the time of their\nimplementation against which future performance of the MPAs can be evaluated. Reef\nCheck has build the capacity to continue monitoring California's MPAs with citizen\nscientists so that we will be able to asses their successes or shortfalls in the future." + }, + { + "id": 146338, + "strid": "f42b15d6-9643-4447-8300-3d593c3d1de9", + "image_id": 206181, + "image_name": "18697.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 218.53, + 30.08, + 85.99999999999997, + 125.94000000000001 + ], + "priority": -1, + "parents": [], + "children": [ + 146318, + 146320, + 146330, + 146315, + 146323, + 146337, + 146328, + 146332, + 146335, + 146325, + 146312, + 146334, + 146321, + 146317, + 146319, + 146316, + 146336, + 146322, + 146326, + 146314, + 146327, + 146324, + 146329, + 146313 + ], + "area": 6573.3823999999995, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 146312, + "strid": "05639da3-c315-4ee8-bd4e-e097fe9a15b1", + "image_id": 206181, + "image_name": "18697.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 328.217, + 58.017, + 999.4989999999999, + 160.839 + ], + "priority": 1, + "parents": [ + 146338 + ], + "children": [], + "area": 19042.165689, + "iscrowd": 0, + "segmentation": [], + "text": "Slivka and Slivka-bio mee\n\nA lightweight, unopinionated framework\nfor executables as web services, applied to bioinformatics" + }, + { + "id": 146313, + "strid": "3edc16bc-7db0-4708-bb4c-a17b2dc57b08", + "image_id": 206181, + "image_name": "18697.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 275.083, + 230.344, + 1010.9869999999999, + 40.20999999999998 + ], + "priority": 2, + "parents": [ + 146338 + ], + "children": [], + "area": 63363.718552000006, + "iscrowd": 0, + "segmentation": [], + "text": "Mateusz Warowny, Stuart MacGowan, Geoff Barton and Jim Procter" + }, + { + "id": 146336, + "strid": "850c2e7d-5186-4c83-9abd-2f0cc24a4977", + "image_id": 206181, + "image_name": "18697.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1637.564, + 91.104, + 328.10000000000014, + 44.33800000000001 + ], + "priority": 3, + "parents": [ + 146338 + ], + "children": [], + "area": 149188.630656, + "iscrowd": 0, + "segmentation": [], + "text": "More Information" + }, + { + "id": 146335, + "strid": "60b26540-14ff-4d17-99ad-c6b42a27ac0a", + "image_id": 206181, + "image_name": "18697.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1638.375, + 218.594, + 757.239, + 206.38600000000002 + ], + "priority": 4, + "parents": [ + 146338 + ], + "children": [], + "area": 358138.94474999997, + "iscrowd": 0, + "segmentation": [], + "text": "Slivka’s homepage provides server status updates, a web\ninterface for executing services (see below), and help\ndocumentation on installation and configuring slivka-bio.\n\nDeveloper and API documentation available from github." + }, + { + "id": 146334, + "strid": "1b3a7ad3-0160-46b8-8ca0-d15fa6aac1df", + "image_id": 206181, + "image_name": "18697.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2530.755, + 99.364, + 208.56500000000005, + 41.5 + ], + "priority": 5, + "parents": [ + 146338 + ], + "children": [ + 146333 + ], + "area": 251465.93982000003, + "iscrowd": 0, + "segmentation": [], + "text": "Availability" + }, + { + "id": 146333, + "strid": "f22f5f43-8ad9-4013-99ba-12727b903f53", + "image_id": 206181, + "image_name": "18697.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2527.563, + 142.992, + 618.2460000000001, + 73.423 + ], + "priority": 6, + "parents": [ + 146334 + ], + "children": [], + "area": 361421.288496, + "iscrowd": 0, + "segmentation": [], + "text": "Slivka and Slivka-bio are open source packages\nreleased under the Apache 2.0 License." + }, + { + "id": 146314, + "strid": "d3e8c23c-51c8-4f0d-811b-5452b3dd0eba", + "image_id": 206181, + "image_name": "18697.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 78.343, + 465.858, + 570.116, + 147.91399999999993 + ], + "priority": 7, + "parents": [ + 146338 + ], + "children": [], + "area": 36496.713294, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 146317, + "strid": "f636a4d3-5617-42cf-8cd0-c36de4bfc904", + "image_id": 206181, + "image_name": "18697.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 77.659, + 632.989, + 704.354, + 312.856 + ], + "priority": 8, + "parents": [ + 146338 + ], + "children": [], + "area": 49157.29275100001, + "iscrowd": 0, + "segmentation": [], + "text": "Why did we create Slivka ?\n\nThe Dundee Resource for Sequence Analysis and Structure\nPrediction provides access to a range of bioinformatics\nmethods, some as web apps, others as programmatic\nservices for the Jalview Multiple Sequence Alignment and\nAnalysis Workbench. Slivka is a new framework that we\nhave developed to provide the next generation of services\nfor the Jalview Desktop Application and JalviewJS, the\nJavaScript implementation of Jalview." + }, + { + "id": 146318, + "strid": "1132be90-8f46-4306-b509-3c617c1acdeb", + "image_id": 206181, + "image_name": "18697.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 79.368, + 980.037, + 714.6120000000001, + 237.63400000000001 + ], + "priority": 9, + "parents": [ + 146338 + ], + "children": [], + "area": 77783.57661599999, + "iscrowd": 0, + "segmentation": [], + "text": "Why do we need yet another web services framework ?\nJalview’'s current web services provide access to\nbioinformatics tools via Java SOAP web services - provided\nby JABAWS 2.2 and some legacy systems. These are difficult\nto maintain and extend for larger datasets. SOAP services\nare also technically complicated, and clients are not easy to\nimplement in JalviewJS, the JavaScript version of Jalview." + }, + { + "id": 146319, + "strid": "19e2f9a5-d44f-4483-a5cd-0ee3074ecd09", + "image_id": 206181, + "image_name": "18697.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 81.078, + 1250.153, + 699.225, + 338.5 + ], + "priority": 10, + "parents": [ + 146338 + ], + "children": [], + "area": 101359.904934, + "iscrowd": 0, + "segmentation": [], + "text": "Surely something like Slivka exists already ?\nSurprisingly, no. Plenty of systems (e.g. Galaxy) provide\nAPIs for remote command execution, but this is often not\ntheir main focus. A small number of ‘command line tool as\nweb services’ systems have also been developed, including\nour own. Most of these are unmaintained, however, or lack\nthe flexibility needed for Jalview's services. There are also\nmany excellent web service APIs provided by national and\ninternational facilities such as EMBL-EBI, but these are not\ndesigned to be easily installed on other systems." + }, + { + "id": 146320, + "strid": "58457899-c1b2-4454-b358-54345e943a8a", + "image_id": 206181, + "image_name": "18697.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 81.078, + 1622.846, + 699.225, + 176.08899999999994 + ], + "priority": 11, + "parents": [ + 146338 + ], + "children": [], + "area": 131577.107988, + "iscrowd": 0, + "segmentation": [], + "text": "Slivka-bio - a new services stack for Jalview 2.12\n\nSlivka is designed to facilitate easy creation of new types of\nservice, and customisation to support features specific to a\nparticular tool. Jalview's web service architecture has been\nrefactored to take advantage of this approach." + }, + { + "id": 146322, + "strid": "94fe7214-8218-43e1-98f8-fa181a6a5e3d", + "image_id": 206181, + "image_name": "18697.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 79.368, + 1822.869, + 697.5160000000001, + 215.40899999999988 + ], + "priority": 12, + "parents": [ + 146338 + ], + "children": [], + "area": 144677.466792, + "iscrowd": 0, + "segmentation": [], + "text": "Semantic Service Metadata\n\nSlivka Service's metadata can include classifiers. In slivka-\nbio, these are drawn from the EDAM ontology. Jalview’s\nclient uses these classifiers to determine where the service\nshould be shown in Jalview's Web Services menu, the\nrequired input data and expected outputs." + }, + { + "id": 146323, + "strid": "2177bfab-500c-4255-91fe-8b9534205e42", + "image_id": 206181, + "image_name": "18697.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 57.144, + 2060.503, + 776.157, + 264.98799999999983 + ], + "priority": 13, + "parents": [ + 146338 + ], + "children": [], + "area": 117745.383432, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 146316, + "strid": "781f6fab-afc3-4ca8-b3c5-7dc9a7a6f5e4", + "image_id": 206181, + "image_name": "18697.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 894.846, + 467.158, + 841.1219999999998, + 111.12400000000002 + ], + "priority": 14, + "parents": [ + 146338 + ], + "children": [], + "area": 418034.467668, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 146315, + "strid": 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"category_name": "Figure", + "bbox": [ + 1901.404, + 1175.571, + 737.0459999999998, + 659.998 + ], + "priority": 20, + "parents": [ + 146338 + ], + "children": [], + "area": 2235235.4016839997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 146326, + "strid": "048801b8-9244-42d2-8ea1-19737317c3f5", + "image_id": 206181, + "image_name": "18697.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1977.754, + 1903.952, + 355.35199999999986, + 371.2270000000001 + ], + "priority": 21, + "parents": [ + 146338 + ], + "children": [], + "area": 3765548.683808, + "iscrowd": 0, + "segmentation": [], + "text": "Inputs and Outputs\n- data type specifications\n\nSlivka-bio’s bioinformatics data\ntypes are mapped to flat-file\nformats supported by Jalview's\ndata import and exporters.\n\nWrapper scripts are used to\ngenerate jalview specific files\n(such as annotations and\nfeatures files), but raw outputs\nare also available." + }, + { + "id": 146332, + "strid": "d7b67293-208a-4c29-8891-a16bcdd25fb6", + "image_id": 206181, + "image_name": "18697.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2530.117, + 391.567, + 395.84799999999996, + 41.5 + ], + "priority": 22, + "parents": [ + 146338 + ], + "children": [ + 146331 + ], + "area": 990710.3233390001, + "iscrowd": 0, + "segmentation": [], + "text": "Slivka-bio with Conda" + }, + { + "id": 146331, + "strid": "5d41683b-3b3d-4611-889c-733d9142bcbf", + "image_id": 206181, + "image_name": "18697.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2529.529, + 435.621, + 707.0349999999999, + 469.2710000000001 + ], + "priority": 23, + "parents": [ + 146332 + ], + "children": [], + "area": 1101915.952509, + "iscrowd": 0, + "segmentation": [], + "text": "Slivka-bio complete with (nearly) all command-line tools can be\ninstalled with the slivka/compbio-services conda environment.\n\nconda env create -n my-slivka-bio slivka/compbio-services\nconda activate my-slivka-bio\n\nconda install mongodb\n\nmkdir mongo_slivka\n\nmongod -dbpath ./mongo_slivka &\n\nslivka-bio start server &\n\nslivka-bio start scheduler &\n\nSlivka-bio start local-queue &\n\ncurl localhost:8000/api/services | less # Check that slivka is up\n\nCommand-line tools such as IUPred are not yet available in conda.\nThese must be manually installed - see\nhttps://bartongroup.github.io/slivka-bio/ for instructions." + }, + { + "id": 146329, + "strid": "0e00af85-28a8-4324-adc4-763a9857efaa", + "image_id": 206181, + "image_name": "18697.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2666.07, + 967.686, + 510.26200000000017, + 379.42600000000004 + ], + "priority": 24, + "parents": [ + 146338 + ], + "children": [], + "area": 2579918.61402, + "iscrowd": 0, + "segmentation": [], + "text": "Slivka’s Runner API\nSpecified in service definition.\n\n* Submit, monitor & manage jobs\n* Inject job-specific resource\nresource parameters\n* Memory requirements\n* Parallel or GPU resources" + }, + { + "id": 146330, + "strid": "8fb946c6-a801-4c2f-98fe-2e44dd3b99f7", + "image_id": 206181, + "image_name": "18697.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2669.685, + 1382.923, + 538.098, + 451.75199999999995 + ], + "priority": 25, + "parents": [ + 146338 + ], + "children": [], + "area": 3691968.7892549997, + "iscrowd": 0, + "segmentation": [], + "text": "Resource limits - work in progress\nIn Slivka 0.8, runners are selected and\n\nconfigured by evaluating python\nfunctions. This allows Cluster or cloud\nexecution parameters to be fine-tuned\naccording to the size of input data, and\nrequested parameters.\n\nWe are currently evaluating expression\nbased approaches that will allow runner\nconfiguration without creation of python\nfunctions." + }, + { + "id": 146325, + "strid": "ca068b1e-7fc1-4041-a54c-4e8df3e35cae", + "image_id": 206181, + "image_name": "18697.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2430.797, + 1902.731, + 659.4160000000002, + 368.7850000000001 + ], + "priority": 26, + "parents": [ + 146338 + ], + "children": [], + "area": 4625152.806607, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 139372, + "strid": "885ad6c6-8ff4-4472-b622-ee7feebc09fa", + "image_id": 205914, + "image_name": "16716.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 6741.65, + 94.84, + 338.4400000000005, + 319.28 + ], + "priority": -1, + "parents": [], + "children": [ + 139367, + 139364, + 139368, + 139357, + 139360, + 139355, + 139363, + 139356 + ], + "area": 639378.086, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 139355, + "strid": "baa5c408-415b-478f-b66a-70e6bfd016cf", + "image_id": 205914, + "image_name": "16716.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 89.732, + 96.915, + 6537.139, + 461.25399999999996 + ], + "priority": 1, + "parents": [ + 139372 + ], + "children": [], + "area": 8696.37678, + "iscrowd": 0, + "segmentation": [], + "text": "ScPipe-ATAC : A flexible R/Bioconductor module for pre-processing\nplatform-independent scATAC-Seq data Lom" + }, + { + "id": 139356, + "strid": "523fd137-01f9-45fb-bded-40119e3dd554", + "image_id": 205914, + "image_name": "16716.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 76.952, + 596.37, + 3236.188, + 317.13199999999995 + ], + "priority": 2, + "parents": [ + 139372 + ], + "children": [], + "area": 45891.86424, + "iscrowd": 0, + "segmentation": [], + "text": "Shanika L. Amarasinghe’, Luyi Tian’, Jafar S. Jabbari2, Matthew E. Ritchie’\n\n1 The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Victoria, Australia\n\n2 Australian Genome Research Facility Ltd, Parkville 3052, Victoria, Australia" + }, + { + "id": 139357, + "strid": "8ef64351-6ac4-4416-b28d-0c3d7b6f6a06", + "image_id": 205914, + "image_name": "16716.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 80.506, + 973.411, + 880.193, + 262.44299999999987 + ], + "priority": 3, + "parents": [ + 139372 + ], + "children": [ + 139371, + 139358, + 139359 + ], + "area": 78365.425966, + "iscrowd": 0, + "segmentation": [], + "text": ": ntroduction\n\nSingle-cell Assay for" + }, + { + "id": 139358, + "strid": "05cfca6f-4f27-4f94-8e40-b069bb357dcf", + "image_id": 205914, + "image_name": "16716.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 160.882, + 1119.938, + 5141.873, + 78.25999999999999 + ], + "priority": 4, + "parents": [ + 139357 + ], + "children": [], + "area": 180177.865316, + "iscrowd": 0, + "segmentation": [], + "text": "Single-cell Assay tor Transposase Accessible Chromatin using sequencing (scATAC-seq) enables genome-wide profiling of chromatin" + }, + { + "id": 139359, + "strid": "6b01af67-fd26-4a73-a753-bd5eb474ed05", + "image_id": 205914, + "image_name": "16716.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 83.519, + 1220.188, + 5226.021, + 576.471 + ], + "priority": 5, + "parents": [ + 139357 + ], + "children": [], + "area": 101908.88157200001, + "iscrowd": 0, + "segmentation": [], + "text": "accessibility that can be used to improve gene expression modelling at single-cell resolution.\n\nscATAC-seq data are intrinsically sparse, since the signals detected at a genomic position are limited by DNA copy number, thereby making\nit difficult to discriminate signals from noise. We have extended scPipe, our current pre-processing tool for single-cell RNA data, to be able to\nprocess scATAC-seq data from a variety of different protocols. We take the power and flexibility of the R environment and create a workflow\nthat allows us to use exsitng Bioconductor packages to achieve this." + }, + { + "id": 139371, + "strid": "a661f983-1e75-4612-a2d6-a0da72127977", + "image_id": 205914, + "image_name": "16716.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 5408.007, + 1029.086, + 1710.808, + 884.492 + ], + "priority": 6, + "parents": [ + 139357 + ], + "children": [], + "area": 5565304.291602, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 139360, + "strid": "2e71bd89-50f6-4310-afb7-3b18e3968074", + "image_id": 205914, + "image_name": "16716.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 81.704, + 1840.644, + 907.649, + 255.58799999999997 + ], + "priority": 7, + "parents": [ + 139372 + ], + "children": [ + 139361, + 139362 + ], + "area": 150387.977376, + "iscrowd": 0, + "segmentation": [], + "text": "orkflow\nHere we are ci" + }, + { + "id": 139361, + "strid": "0ee0692f-9c6c-4d02-a92b-ca3fb4a736c0", + "image_id": 205914, + "image_name": "16716.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 471.37, + 1981.224, + 6367.869, + 78.37700000000018 + ], + "priority": 8, + "parents": [ + 139360 + ], + "children": [], + "area": 933889.5568799999, + "iscrowd": 0, + "segmentation": [], + "text": "Here we are comparing the established scPipe RNA-Seg workfflow (/c/i) side by side with scATAC-Segq workflow (right) to understand the similarity and differences in the two" + }, + { + "id": 139362, + "strid": "78509139-76af-4a81-baa2-777edb96aa6f", + "image_id": 205914, + "image_name": "16716.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 89.714, + 2081.903, + 4154.171, + 74.43899999999985 + ], + "priority": 9, + "parents": [ + 139360 + ], + "children": [], + "area": 186775.84574199998, + "iscrowd": 0, + "segmentation": [], + "text": "concepts. Current devel version of scPipe-ATAC functions are in https://github.com/shaniAmare/scPipe-ATAC." + }, + { + "id": 139367, + "strid": "1cc4305a-f969-4bf4-b31f-64af41624f70", + "image_id": 205914, + "image_name": "16716.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 165.436, + 2367.274, + 121.352, + 1396.6460000000002 + ], + "priority": 10, + "parents": [ + 139372 + ], + "children": [ + 139365 + ], + "area": 391632.341464, + "iscrowd": 0, + "segmentation": [], + "text": "SUISS9IOJd91d bas-WNYIS" + }, + { + "id": 139365, + "strid": "09016fc4-932a-49c1-9673-22b005a9d751", + "image_id": 205914, + "image_name": "16716.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 516.346, + 2196.017, + 2990.721, + 1656.9210000000003 + ], + "priority": 11, + "parents": [ + 139367 + ], + "children": [], + "area": 1133904.5938819998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 139368, + "strid": "e5fbc5fe-6ce5-4f09-9cbb-03c1d262b307", + "image_id": 205914, + "image_name": "16716.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3741.584, + 2339.995, + 121.3789999999999, + 1431.7439999999997 + ], + "priority": 12, + "parents": [ + 139372 + ], + "children": [ + 139366 + ], + "area": 8755287.852079999, + "iscrowd": 0, + "segmentation": [], + "text": "P10] CXt- oles (ot B lo ole lsee hyd Ry el)" + }, + { + "id": 139366, + "strid": "b95aa8e8-de1e-4c55-b5a4-a222eaf804bb", + "image_id": 205914, + "image_name": "16716.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 4093.363, + 2197.249, + 2895.3129999999996, + 1679.859 + ], + "priority": 13, + "parents": [ + 139368 + ], + "children": [], + "area": 8994137.758387, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 139363, + "strid": "95ceb65a-3760-454e-bc3f-a3c1b7e75cae", + "image_id": 205914, + "image_name": "16716.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 84.272, + 3912.258, + 2060.786, + 265.5609999999997 + ], + "priority": 14, + "parents": [ + 139372 + ], + "children": [ + 139369 + ], + "area": 329693.806176, + "iscrowd": 0, + "segmentation": [], + "text": "Coon srnane is and the Future\n\n«= ScPipe-ATAC Is able to generate a Single C Cell!" + }, + { + "id": 139369, + "strid": "6028298d-5778-4eee-a05d-4396fc543617", + "image_id": 205914, + "image_name": "16716.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 340.916, + 4048.251, + 4104.565, + 285.03399999999965 + ], + "priority": 15, + "parents": [ + 139363 + ], + "children": [], + "area": 1380113.537916, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 139364, + "strid": "bb81b004-bd31-40b8-bd2d-48043fe0efdc", + "image_id": 205914, + "image_name": "16716.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 89.252, + 4401.795, + 404.114, + 53.134000000000015 + ], + "priority": 16, + "parents": [ + 139372 + ], + "children": [ + 139370 + ], + "area": 392869.00734, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 139370, + "strid": "9526c714-3ca8-4e2a-8586-6290b9c36bdf", + "image_id": 205914, + "image_name": "16716.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 88.465, + 4467.739, + 4518.728, + 246.192 + ], + "priority": 17, + "parents": [ + 139364 + ], + "children": [], + "area": 395238.530635, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178398, + "strid": "c9b216ad-e5d1-45a5-8f76-b911a401c405", + "image_id": 207462, + "image_name": "8213.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 1122.97, + 16.13, + 93.6099999999999, + 29.250000000000004 + ], + "priority": -1, + "parents": [], + "children": [ + 178386, + 178383, + 178385, + 178393, + 178390, + 178396, + 178387, + 178394, + 178395, + 178379, + 178380, + 178389, + 178384, + 178391, + 178382, + 178397, + 178388, + 178392, + 178381 + ], + "area": 18113.5061, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178379, + "strid": "6d5fde2b-3644-469f-b339-849b1232003c", + "image_id": 207462, + "image_name": "8213.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 200.593, + 43.923, + 908.6940000000001, + 139.913 + ], + "priority": 1, + "parents": [ + 178398 + ], + "children": [], + "area": 8810.646338999999, + "iscrowd": 0, + "segmentation": [], + "text": "MOLLUSCS ON THE MOVE IN TASMANIAN\nWATERS? POSSIBLE SOUTHWARD RANGE\n| SHIFTS AMONG MARINE SPECIES" + }, + { + "id": 178380, + "strid": "5d491b9e-7d22-4167-bf61-ab80438fc99c", + "image_id": 207462, + "image_name": "8213.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 260.503, + 222.542, + 779.345, + 89.826 + ], + "priority": 2, + "parents": [ + 178398 + ], + "children": [], + "area": 57972.858625999994, + "iscrowd": 0, + "segmentation": [], + "text": "Dr Simon Grove! & Rob de Little?\n\n‘Tasmanian Museum and Art Gallery, Hobart; 2Port Arthur, TAS" + }, + { + "id": 178381, + "strid": "09406e40-931a-4fd7-bdd1-1eea7d7fd777", + "image_id": 207462, + "image_name": "8213.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 4.326, + 143.819, + 228.193, + 197.48800000000003 + ], + "priority": 3, + "parents": [ + 178398 + ], + "children": [], + "area": 622.1609939999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178382, + "strid": "208454db-3be0-4bd6-80f9-0d3166a3df4d", + "image_id": 207462, + "image_name": "8213.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1119.022, + 75.832, + 173.05600000000004, + 262.629 + ], + "priority": 4, + "parents": [ + 178398 + ], + "children": [], + "area": 84857.676304, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178383, + "strid": "22ccde98-58a5-4685-90e4-0a63d3356c1b", + "image_id": 207462, + "image_name": "8213.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 18.861, + 348.515, + 1246.614, + 65.57999999999998 + ], + "priority": 5, + "parents": [ + 178398 + ], + "children": [], + "area": 6573.341415, + "iscrowd": 0, + "segmentation": [], + "text": "The southward extension of the warm-water East Australian Current down Tasmania's east coast is now a well-documented phenomenon, and evidence for\nits effects on the distribution of marine biota is mounting. Over the past decade, through extensive shore-based collecting and boat-based dredging, we\nhave identified many marine mollusc species that were not previously recognised as occurring this far south. This poster explores some of our findings." + }, + { + "id": 178385, + "strid": "8dcf9c6b-d711-472e-90c0-dae2e8b539d8", + "image_id": 207462, + "image_name": "8213.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 47.39, + 453.578, + 329.802, + 427.746 + ], + "priority": 6, + "parents": [ + 178398 + ], + "children": [], + "area": 21495.061419999998, + "iscrowd": 0, + "segmentation": [], + "text": "Over the past decade, we have collected 971\netree coe een re\nEee ae eee me Rue Rg\neta ecse cel eng eee)\nDT se cee t\n\nfoe een ue uae cn)\nfee eee eR can eee\nArt Gallery, the Queen Victoria Museum and\nger AER ue ne ea\nNet Ae eee oe\nCoote eg tees cee ne\nSU ene te umes\nPeele cement aunt atc\nCote meng tec ne SY et\nem tance Rotate eck eens)\nRae ee ech ache celica\nken eet ec er Somos ecucae\naren tec Rede tenes sce eS\nei cue a Sea Reta oe\nTenet USeeROa ar ees irs ACOs\nRee ee Romer uum cry\nSegue eee menu\nwaters." + }, + { + "id": 178384, + "strid": "a28858b5-6fb3-46a9-8e5e-ca4f5016b5c5", + "image_id": 207462, + "image_name": "8213.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 440.516, + 433.334, + 417.099, + 65.59699999999998 + ], + "priority": 7, + "parents": [ + 178398 + ], + "children": [], + "area": 190890.560344, + "iscrowd": 0, + "segmentation": [], + "text": "Latitudinal comparison of our southernmost post-\n2005 records of Tasmanian marine mollusc species\n(n = 948) with those of previous / other recorders" + }, + { + "id": 178387, + "strid": "d78863cf-8c8a-41d8-8dfa-31b5886dd2b9", + "image_id": 207462, + "image_name": "8213.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 425.898, + 505.929, + 446.948, + 374.922 + ], + "priority": 8, + "parents": [ + 178398 + ], + "children": [], + "area": 215474.149242, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178386, + "strid": "90b36247-441c-4b3a-9234-62dde878f11a", + "image_id": 207462, + "image_name": "8213.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 916.201, + 448.454, + 348.269, + 429.886 + ], + "priority": 9, + "parents": [ + 178398 + ], + "children": [], + "area": 410874.00325400004, + "iscrowd": 0, + "segmentation": [], + "text": "ORE lees ua Ce eee eco nell\nCte eee Cornea ad\neee Caer)\ndisplacements for a further 13% of species,\nmostly in the range of 1 to 3 degrees of latitude,\nEc oat cnc\nEnel Renew cs\nsouthward displacements for the remaining 12%\nCe eeeemae te eee urn mara hog\nDe enn acces\nlatitude (roughly 800 km). We cannot be sure\nPee Reg gece ccs a eRe\nINC ee teeta ean rset\nDene Reet ee scam Cu naka\n(Creer nome cn Mure tacks utes\neee Sees ecru tes Acls\n\nite ee RUM N Rue e ame ts\nNeve oem Cee ecg\nRete so een eet eee kae ec\nOCIS OIE Ca CECE LeRs el SMM Meneses\nlikely candidates include benthic species with\nPere a ean cut aOR ens gc\nBeen" + }, + { + "id": 178388, + "strid": "152f1163-c8ab-4417-b3e4-a860b39ecab7", + "image_id": 207462, + "image_name": "8213.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 28.314, + 905.125, + 330.369, + 237.58500000000004 + ], + "priority": 10, + "parents": [ + 178398 + ], + "children": [], + "area": 25627.70925, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178393, + "strid": "dd6b48a6-77af-4214-a0c1-a3b3366bde91", + "image_id": 207462, + "image_name": "8213.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 24.143, + 1143.92, + 333.442, + 100.16800000000012 + ], + "priority": 11, + "parents": [ + 178398 + ], + "children": [], + "area": 27617.660560000004, + "iscrowd": 0, + "segmentation": [], + "text": "oa etal a\nRee eet et ace ad\nPen Ria em eee Rue cas\nArthur in SE TAS. We suspect that these species, and\nmany others showing similar trends, were here all\nPeeirtiinite me rietice cc" + }, + { + "id": 178389, + "strid": "d59b58f6-1de1-49d0-9299-02eb7d938feb", + "image_id": 207462, + "image_name": "8213.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 65.498, + 1250.752, + 250.70500000000004, + 122.85100000000011 + ], + "priority": 12, + "parents": [ + 178398 + ], + "children": [], + "area": 81921.75449600001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178394, + "strid": "63299b3a-0520-405d-a8c4-d59ec97472cb", + "image_id": 207462, + "image_name": "8213.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 35.561, + 1373.678, + 312.934, + 99.12799999999993 + ], + "priority": 13, + "parents": [ + 178398 + ], + "children": [], + "area": 48849.363358, + "iscrowd": 0, + "segmentation": [], + "text": "These two species — a false-olive and a top-shell —\nMeee ee an cu La\nGeer ena aOR\nBee es ee\nSeen ee eure\nPech Cicer nance serie?" + }, + { + "id": 178390, + "strid": "56cf0a42-b19e-4e73-960f-0231f2682489", + "image_id": 207462, + "image_name": "8213.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 395.832, + 910.858, + 240.55600000000004, + 460.11799999999994 + ], + "priority": 14, + "parents": [ + 178398 + ], + "children": [], + "area": 360546.74385599996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178395, + "strid": "cdcbbf99-2bc2-4ec3-9f2f-46a7e200141e", + "image_id": 207462, + "image_name": "8213.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 383.506, + 1373.604, + 247.43399999999997, + 100.60099999999989 + ], + "priority": 15, + "parents": [ + 178398 + ], + "children": [], + "area": 526785.375624, + "iscrowd": 0, + "segmentation": [], + "text": "ee ee Le\nPeeee eS UU eRe\nSOS eee een eee\nsouthwards down the full length of the\nCee ee ee\nstill of juvenile shells." + }, + { + "id": 178391, + "strid": "fb5fa42d-3036-4735-905d-259319ae14ea", + "image_id": 207462, + "image_name": "8213.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 677.397, + 909.554, + 292.89, + 396.3460000000001 + ], + "priority": 16, + "parents": [ + 178398 + ], + "children": [], + "area": 616129.1509380001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178396, + "strid": "7e79922c-98c9-4422-ab0c-c86ad7ab715d", + "image_id": 207462, + "image_name": "8213.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 663.21, + 1322.321, + 315.80899999999997, + 131.587 + ], + "priority": 17, + "parents": [ + 178398 + ], + "children": [], + "area": 876976.51041, + "iscrowd": 0, + "segmentation": [], + "text": "See ee ea\nSOE en eee ere\nORES eRe\njourney, unable to return to their preferred tropical\nRemon s eg\nPees iS eeu Uae\nCer MMR eg eee ei\neee eeketen" + }, + { + "id": 178392, + "strid": "e55e2507-a60e-48bb-9b24-24f56ac9ffc5", + "image_id": 207462, + "image_name": "8213.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1018.728, + 909.761, + 254.93899999999996, + 436.15200000000004 + ], + "priority": 18, + "parents": [ + 178398 + ], + "children": [], + "area": 926799.0040079999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178397, + "strid": "1a0a294d-ef9e-43e0-a6ee-e4d235363dc6", + "image_id": 207462, + "image_name": "8213.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1011.958, + 1349.535, + 261.938, + 115.14200000000005 + ], + "priority": 19, + "parents": [ + 178398 + ], + "children": [], + "area": 1365672.7395300001, + "iscrowd": 0, + "segmentation": [], + "text": "Deel ees\nPee ea eee nen\neen dees eu Su ea\nSee Renu\neae Ua CMe en\nCiemiccrpa te msg eat)\nPerret eI" + }, + { + "id": 170351, + "strid": "aaa35475-3e05-4484-93b6-56b99f50bf52", + "image_id": 207148, + "image_name": "7020.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 143.77, + 124.33, + -143.77, + -124.33 + ], + "priority": -1, + "parents": [], + "children": [ + 170322, + 170332, + 170319, + 170327, + 170329, + 170330, + 170321, + 170326, + 170323, + 170324, + 170320, + 170333, + 170328, + 170325 + ], + "area": 17874.9241, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 170319, + "strid": "cd8a3739-5684-47ab-9a95-3b19455726fc", + "image_id": 207148, + "image_name": "7020.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 579.072, + 48.743, + 2264.017, + 256.082 + ], + "priority": 1, + "parents": [ + 170351 + ], + "children": [], + "area": 28225.706496000003, + "iscrowd": 0, + "segmentation": [], + "text": "SLiMScape 3.x: a Cytoscape 3 app for discovery of\nShort Linear Motifs in protein interaction networks" + }, + { + "id": 170320, + "strid": "22cb79b2-2c51-4153-bd5d-6cce522bace2", + "image_id": 207148, + "image_name": "7020.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 255.391, + 350.22, + 2791.592, + 181.12 + ], + "priority": 2, + "parents": [ + 170351 + ], + "children": [], + "area": 89443.03602, + "iscrowd": 0, + "segmentation": [], + "text": "Emily Olorin’, Kevin T. O'Brien2, Nicolas Palopoli345, Asa Pérez-Bercoff!, Denis C. Shields? and Richard J. Edwards!2\n\n1. School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia; 2. UCD Conway Institute of Biomolecular and Biomedical Research, School of Medicine, University College Dublin, Dublin, Ireland;\n3. Centre for Biological Sciences & Institute for Life Sciences, University of Southampton, Southampton, UK; 4. Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, Bernal, Argentina; 5. Instituto Leloir, Buenos Aires, Argentina." + }, + { + "id": 170328, + "strid": "3facd7ba-17df-4f15-8ed7-19f5ec663e1e", + "image_id": 207148, + "image_name": "7020.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 423.998, + 668.691, + 1225.116, + 316.054 + ], + "priority": 3, + "parents": [ + 170351 + ], + "children": [], + "area": 283523.646618, + "iscrowd": 0, + "segmentation": [], + "text": "Tools of the SLiMSuite package identify enriched sequence\npatterns due to convergent evolution in non-homologous\nproteins, using a statistical model to identify SLIM enrichment\nbased on the evolutionary relationships, amino acid\ncomposition and predicted disorder of the input proteins. Input\ndata quality is critical for successful SLIM prediction." + }, + { + "id": 170329, + "strid": "e30c926d-15ce-4316-8fbf-caa6e53b7152", + "image_id": 207148, + "image_name": "7020.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 98.911, + 1073.651, + 829.3509999999999, + 742.0620000000001 + ], + "priority": 4, + "parents": [ + 170351 + ], + "children": [ + 170349 + ], + "area": 106195.89406100001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 170349, + "strid": "d6d241d0-e7e2-4597-a5d7-232f4324ea0a", + "image_id": 207148, + "image_name": "7020.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 449.166, + 1170.602, + 319.19199999999995, + 153.72800000000007 + ], + "priority": 5, + "parents": [ + 170329 + ], + "children": [], + "area": 525794.6179320001, + "iscrowd": 0, + "segmentation": [], + "text": "PPI network imported\nfrom IntAct for WD40-\ncoontaining proiteins\nBTRC and FBXWI11" + }, + { + "id": 170333, + "strid": "4ef57832-e42a-4544-8e42-4c069605f43d", + "image_id": 207148, + "image_name": "7020.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 92.214, + 1891.89, + 1150.6, + 255.84199999999987 + ], + "priority": 6, + "parents": [ + 170351 + ], + "children": [], + "area": 174458.74446000002, + "iscrowd": 0, + "segmentation": [], + "text": "SLiMScape embeds SLiMSuite tools within the Cytoscape\ninteractive framework. SLiMScape makes it easier to (1)\ngenerate high quality hypothesis-driven datasets for these\ntools, and (2) visualise predicted SLIM occurrences within\nthe context of the network." + }, + { + "id": 170332, + "strid": "040719ca-5cc2-4568-a25a-4c8334f4e0f9", + "image_id": 207148, + "image_name": "7020.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 989.179, + 1196.31, + 1173.149, + 153.13400000000001 + ], + "priority": 7, + "parents": [ + 170351 + ], + "children": [], + "area": 1183364.7294899998, + "iscrowd": 0, + "segmentation": [], + "text": "Cytoscape provides a user-friendly, interactive environment\nto explore interaction networks and select proteins based\non common features, such as shared interaction partners." + }, + { + "id": 170330, + "strid": "3b9d16d7-6dae-42d1-b4c1-f915c7946849", + "image_id": 207148, + "image_name": "7020.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1256.311, + 1444.994, + 840.8150000000003, + 776.1290000000001 + ], + "priority": 8, + "parents": [ + 170351 + ], + "children": [ + 170331 + ], + "area": 1815361.8571339997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 170331, + "strid": "8e8080c4-a539-47b4-a3dc-7ed3c11c6d73", + "image_id": 207148, + "image_name": "7020.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1069.829, + 1462.434, + 335.58899999999994, + 118.71499999999992 + ], + "priority": 9, + "parents": [ + 170330 + ], + "children": [], + "area": 1564554.303786, + "iscrowd": 0, + "segmentation": [], + "text": "Reduced IntAct network\nof joint BTRC and\nFBXW11 PPI partners." + }, + { + "id": 170321, + "strid": "47d10baf-4384-4979-8511-83f4117485b1", + "image_id": 207148, + "image_name": "7020.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1817.626, + 643.031, + 205.72900000000004, + 71.52099999999996 + ], + "priority": 10, + "parents": [ + 170351 + ], + "children": [ + 170339, + 170338 + ], + "area": 1168789.864406, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 170339, + "strid": "082cb67b-a4e8-4b8e-9a88-870b5505d983", + "image_id": 207148, + "image_name": "7020.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1794.929, + 785.376, + 789.096, + 282.6110000000001 + ], + "priority": 11, + "parents": [ + 170321 + ], + "children": [], + "area": 1409694.158304, + "iscrowd": 0, + "segmentation": [], + "text": "What is a Short Linear Motif?\n\nShort Linear Motifs (SLiMs) are protein interaction motifs\nwith certain defining characteristics:\n\nShort: generally <10aa long with <6 defined residues\nLinear: involving residues adjacent in sequence\nMotifs: a recurring sequence pattern required for function" + }, + { + "id": 170338, + "strid": "ceafaaa7-8e50-428d-8148-c83c47743d51", + "image_id": 207148, + "image_name": "7020.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2637.101, + 782.954, + 578.2429999999999, + 277.19499999999994 + ], + "priority": 12, + "parents": [ + 170321 + ], + "children": [], + "area": 2064728.776354, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 170322, + "strid": "537573bd-233f-4e3f-9675-0b5dbb871182", + "image_id": 207148, + "image_name": "7020.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2279.925, + 1230.276, + 367.4659999999999, + 72.92599999999993 + ], + "priority": 13, + "parents": [ + 170351 + ], + "children": [ + 170337 + ], + "area": 2804937.0093000005, + "iscrowd": 0, + "segmentation": [], + "text": "SLUMFinder" + }, + { + "id": 170337, + "strid": "c7c869ff-1801-4fd2-bb96-894b19c5c8ba", + "image_id": 207148, + "image_name": "7020.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2236.914, + 1342.409, + 1039.069, + 887.4380000000001 + ], + "priority": 14, + "parents": [ + 170322 + ], + "children": [ + 170336 + ], + "area": 3002853.4858260006, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 170336, + "strid": "a232067f-633f-4ef1-83d5-1674755c8191", + "image_id": 207148, + "image_name": "7020.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2238.225, + 2247.807, + 969.136, + 77.71300000000019 + ], + "priority": 15, + "parents": [ + 170337 + ], + "children": [], + "area": 5031097.822574999, + "iscrowd": 0, + "segmentation": [], + "text": "Proteins are clustered by homology to identify convergence in unrelated\nproteins. Red nodes contain a predicted SLiM: DSG." + }, + { + "id": 170323, + "strid": "6de7c288-c187-4c40-b7ec-4aff88554dea", + "image_id": 207148, + "image_name": "7020.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 72.668, + 2263.914, + 315.561, + 69.63299999999981 + ], + "priority": 16, + "parents": [ + 170351 + ], + "children": [ + 170335, + 170347, + 170334 + ], + "area": 164514.10255200003, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 170335, + "strid": "426b82f3-573f-411b-8924-8f57a5587aae", + "image_id": 207148, + "image_name": "7020.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 34.328, + 2369.858, + 1243.879, + 714.7739999999999 + ], + "priority": 17, + "parents": [ + 170323 + ], + "children": [], + "area": 81352.48542400001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 170347, + "strid": "893ce4a0-e690-4fc0-91b4-c9c24e45fea2", + "image_id": 207148, + "image_name": "7020.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 35.331, + 3099.719, + 1230.767, + 237.38999999999987 + ], + "priority": 18, + "parents": [ + 170323 + ], + "children": [], + "area": 109516.17198900001, + "iscrowd": 0, + "segmentation": [], + "text": "SLiMProb results for DSG and DSG. {2,3}[ST] motifs in FBXW11/BTRC interactors.\nMerged PPI and homology network. Blue dotted lines represent sequence homology. Nodes\nare coloured and shaped according to motif occurrences: DSG, orange; DSG. {2,3}[ST],\ndark red; conserved DSG, circles; conserved DSG. {2,3}[ST], hexagons; no motifs, blue\nrectangles. The dark red circles (WWTR1 and TRIM9) have conserved DSG occurrences\nand unconserved DSG. {2,3}[ST] occurrences." + }, + { + "id": 170334, + "strid": "51bba0ba-c07a-4ee2-aa12-8e68cec1089e", + "image_id": 207148, + "image_name": "7020.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1433.35, + 2511.369, + 467.076, + 672.9769999999999 + ], + "priority": 19, + "parents": [ + 170323 + ], + "children": [ + 170350 + ], + "area": 3599670.75615, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 170350, + "strid": "35dd7d04-16b3-4fbb-a186-c86e2d6a1179", + "image_id": 207148, + "image_name": "7020.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1443.022, + 3213.088, + 437.88300000000004, + 82.45400000000018 + ], + "priority": 20, + "parents": [ + 170334 + ], + "children": [], + "area": 4636556.671936, + "iscrowd": 0, + "segmentation": [], + "text": "Interacts with top face of WD40\npropeller." + }, + { + "id": 170324, + "strid": "4978c982-d4dc-4c78-a213-85b4775f75b9", + "image_id": 207148, + "image_name": "7020.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2078.753, + 2390.077, + 418.029, + 86.18100000000004 + ], + "priority": 21, + "parents": [ + 170351 + ], + "children": [ + 170343, + 170342, + 170340, + 170341 + ], + "area": 4968379.733981001, + "iscrowd": 0, + "segmentation": [], + "text": "OSLUMFinder" + }, + { + "id": 170343, + "strid": "3a614a54-1055-444d-860b-d4083b75a383", + "image_id": 207148, + "image_name": "7020.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2036.192, + 2499.2, + 1228.2690000000002, + 192.21900000000005 + ], + "priority": 22, + "parents": [ + 170324 + ], + "children": [], + "area": 5088851.046399999, + "iscrowd": 0, + "segmentation": [], + "text": "SLiMs show rapid evolutionary dynamics and are frequently the\ntargets of molecular mimicry by pathogens. QSLiMFinder increases\nprediction sensitivity by restricting the search to patterns occurring in\na specific query protein: in this case, HIV Vpu." + }, + { + "id": 170342, + "strid": "076e2b18-d627-4144-8556-7d687446368c", + "image_id": 207148, + "image_name": "7020.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2040.22, + 2716.008, + 1232.8419999999999, + 355.5569999999998 + ], + "priority": 23, + "parents": [ + 170324 + ], + "children": [], + "area": 5541253.841759999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 170341, + "strid": "dcd10002-7f7f-4d89-b968-a2b44c4daa1c", + "image_id": 207148, + "image_name": "7020.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2038.606, + 3095.32, + 1128.6010000000003, + 37.365999999999985 + ], + "priority": 24, + "parents": [ + 170324 + ], + "children": [], + "area": 6310137.92392, + "iscrowd": 0, + "segmentation": [], + "text": "Jobs are run and results can be accessed directly using the SLiMSuite REST servers:" + }, + { + "id": 170340, + "strid": "262ca07a-7a6c-48e6-ba3c-6057a8d7d0fa", + "image_id": 207148, + "image_name": "7020.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2286.926, + 3138.198, + 803.1689999999999, + 252.29700000000003 + ], + "priority": 25, + "parents": [ + 170324 + ], + "children": [], + "area": 7176826.599347999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 170325, + "strid": "8d097520-7696-4b5b-b0e3-2ba9d4d469b4", + "image_id": 207148, + "image_name": "7020.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 112.262, + 3440.101, + 278.975, + 87.51999999999998 + ], + "priority": 26, + "parents": [ + 170351 + ], + "children": [ + 170348, + 170346 + ], + "area": 386192.61846200004, + "iscrowd": 0, + "segmentation": [], + "text": "Masking" + }, + { + "id": 170348, + "strid": "e4a84b29-0d4d-4fea-9ee3-acc747e57903", + "image_id": 207148, + "image_name": "7020.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 88.408, + 3556.022, + 1376.196, + 118.10100000000011 + ], + "priority": 27, + "parents": [ + 170325 + ], + "children": [], + "area": 314380.792976, + "iscrowd": 0, + "segmentation": [], + "text": "SLiMs typically occur in structurally disordered regions of proteins. Functional instances tend to show\nhigher sequence conservation than their local context. SLiM prediction specificity can be enhanced by\nmasking sequences based on disorder prediction and the “relative local conservation” of residues." + }, + { + "id": 170346, + "strid": "37084dfc-faf8-465f-932e-99af00fe5924", + "image_id": 207148, + "image_name": "7020.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 141.557, + 3696.447, + 1336.896, + 776.8710000000001 + ], + "priority": 28, + "parents": [ + 170325 + ], + "children": [], + "area": 523257.947979, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 170326, + "strid": "b7aeb2ab-9494-4b02-832c-5b2abb39a01d", + "image_id": 207148, + "image_name": "7020.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1796.115, + 3441.431, + 343.5310000000002, + 92.46199999999999 + ], + "priority": 29, + "parents": [ + 170351 + ], + "children": [ + 170344 + ], + "area": 6181205.840565, + "iscrowd": 0, + "segmentation": [], + "text": "Availability" + }, + { + "id": 170344, + "strid": "a997687b-a584-4669-80c1-0311605f6cea", + "image_id": 207148, + "image_name": "7020.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1962.404, + 3577.253, + 1079.1910000000003, + 284.0749999999998 + ], + "priority": 30, + "parents": [ + 170326 + ], + "children": [], + "area": 7020015.596212001, + "iscrowd": 0, + "segmentation": [], + "text": "SLiMScape and SLiMSuite are open source and freely\navailable via GitHub under GNU licenses. SLiMScape\nis also available via the Cytoscape app store.\n\nhttp://www.slimsuite.unsw.edu.au\nhttp://slimsuite.blogspot.com.au" + }, + { + "id": 170327, + "strid": "fcfd960a-655d-4523-8a6c-963299102ae7", + "image_id": 207148, + "image_name": "7020.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1798.527, + 3988.225, + 429.46399999999994, + 76.60899999999992 + ], + "priority": 31, + "parents": [ + 170351 + ], + "children": [ + 170345 + ], + "area": 7172930.344575, + "iscrowd": 0, + "segmentation": [], + "text": "Find out more" + }, + { + "id": 170345, + "strid": "b34e83eb-70e4-425e-90e6-2992eaf836ee", + "image_id": 207148, + "image_name": "7020.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1770.933, + 4105.218, + 1071.5879999999997, + 345.1170000000002 + ], + "priority": 32, + "parents": [ + 170327 + ], + "children": [], + "area": 7270066.028394, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 168666, + "strid": "29ab805b-1790-490a-bedd-56384970ccd3", + "image_id": 207089, + "image_name": "6950.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 79.85, + 89.27, + 312.89, + 306.5 + ], + "priority": -1, + "parents": [], + "children": [ + 168650, + 168654, + 168649, + 168653, + 168652, + 168648, + 168651 + ], + "area": 7128.209499999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 168648, + "strid": "d9f41df1-a01d-4a19-95da-65bcb532fa05", + "image_id": 207089, + "image_name": "6950.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 744.573, + 186.569, + 2583.523, + 88.023 + ], + "priority": 1, + "parents": [ + 168666 + ], + "children": [], + "area": 138914.24003699998, + "iscrowd": 0, + "segmentation": [], + "text": "The Role of the Magnocellular Visual Pathway in Object Recognition" + }, + { + "id": 168649, + "strid": "44a9faa5-e988-44bf-9829-522918af21b7", + "image_id": 207089, + "image_name": "6950.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 799.122, + 397.417, + 2466.396, + 163.935 + ], + "priority": 2, + "parents": [ + 168666 + ], + "children": [], + "area": 317584.667874, + "iscrowd": 0, + "segmentation": [], + "text": "Anna Bognar', Gergo Csete?, Péter Csibri', Zsigmond Tamas Kincses’, Gyula Sary'\n‘University of Szeged, Department of Physiology, 7Department of Neurology" + }, + { + "id": 168650, + "strid": "2cb5bcfa-3ec0-4b3c-8aed-1b0a475b067a", + "image_id": 207089, + "image_name": "6950.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 129.044, + 691.973, + 175.465, + 38.511999999999944 + ], + "priority": 3, + "parents": [ + 168666 + ], + "children": [ + 168655 + ], + "area": 89294.963812, + "iscrowd": 0, + "segmentation": [], + "text": "Abstract" + }, + { + "id": 168655, + "strid": "165b559a-f6d3-4dd0-87cc-eaceaa1eda31", + "image_id": 207089, + "image_name": "6950.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 128.135, + 771.058, + 3265.1709999999994, + 418.96399999999994 + ], + "priority": 4, + "parents": [ + 168650 + ], + "children": [], + "area": 98799.51683, + "iscrowd": 0, + "segmentation": [], + "text": "Visual categorization plays an important role in the fast and efficient processing of information surrounding us, still the neuronal basis of fast categorization has not been\nestablished. Two main hypotheses are known, both agree that the primary impressions are based on information acquired through the magnocellular pathway (MP). It is unclear\nwhether this information is due to the MP running parallel to the ventral pathway or to the top-down mechanisms executed through the connections of the dorsal pathway and\nthe frontal cortex. A categorization task was performed by 39 subjects, who decided about the size of objects based on their first impression. Stimuli used for the MP and\nparvocellular pathways (PP) were discriminated by their spatial frequency content. Transcranial direct-current stimulation (tDCS) were used to assess the role of frontal areas.\nStimulation did not bias the accuracy of decision for stimuli optimized for the PP. In case of stimuli optimized for the MP, cathodal stimulation decreased the subjects’\nperformance, whereas the anodal stimulation increased their performance. Our results support the hypothesis that top-down mechanisms, which promote fast predictions\nthrough coarse information carried to the orbitofrontal cortex (OFC) by the MP, are crucial in fast categorization processes." + }, + { + "id": 168651, + "strid": "d58d410e-cc90-4798-bc18-f63fcc27c30e", + "image_id": 207089, + "image_name": "6950.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 131.861, + 1244.89, + 255.93100000000004, + 40.194999999999936 + ], + "priority": 5, + "parents": [ + 168666 + ], + "children": [ + 168656, + 168661 + ], + "area": 164152.44029, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 168656, + "strid": "57db6f9c-5417-4328-88b4-b351b97dfd6f", + "image_id": 207089, + "image_name": "6950.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 131.038, + 1311.26, + 1969.3449999999998, + 811.2810000000002 + ], + "priority": 6, + "parents": [ + 168651 + ], + "children": [], + "area": 171824.88788000002, + "iscrowd": 0, + "segmentation": [], + "text": "Fast decision concerning information in our environment requires categorization to discriminate between e.g., living\nand non-living, plants and animals, vehicles and buildings. Categorization is important not only in discrimination but\nalso in generalization when physically different objects are grouped on the basis of their similar features. For a fast\nand efficient operation of categorization it is essential to find the optimal level where relevant information and\nactual goals should be considered. These processes rest anatomically and physiologically on the two major visual\nprocessing streams, the MP and PP.\n\nResearchers agree that fast categorization is based on the anatomical characteristics of the MP. However. it is\nunclear, whether this information, leaving V1 reaches the inferotemporal cortex (IT) via the dorsal or the ventral\npathway. According to the suggestion of Thorpe et al, MP information supports PP processing through fast, local\nfeed-back circuits. On the other hand Kveraga and his colleagues hypothesized a top-down process, which, using\nthe rapid processing in the MP, could provide the IT through the OFC with coarse but fast information. This can limit\nthe number of possible interpretations, decrease the number of necessary computation and the time needed.\n\nOur goal was to modulate the function of OFC using tDCS. This method manipulates the cortical network activity\ntransitionally and reversibly in a non-invasive and nonpainful way. We assumed that changes in the performance of\nparticipants allow us to make hypotheses about the role of OFC in a categorisation task where MP and PP\noptimalised stimuli were used." + }, + { + "id": 168661, + "strid": "fe5222bf-c7ce-44ea-86b0-b5d73d926e0c", + "image_id": 207089, + "image_name": "6950.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2169.434, + 1214.724, + 1292.828, + 933.7459999999999 + ], + "priority": 7, + "parents": [ + 168651 + ], + "children": [], + "area": 2635263.546216, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 168652, + "strid": "a2047336-f986-4d23-8f8c-b54421154d73", + "image_id": 207089, + "image_name": "6950.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 124.221, + 2195.221, + 188.152, + 40.61499999999978 + ], + "priority": 8, + "parents": [ + 168666 + ], + "children": [ + 168662, + 168657, + 168663 + ], + "area": 272692.547841, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 168657, + "strid": "10e52b30-4441-4d07-8628-37e683551cb2", + "image_id": 207089, + "image_name": "6950.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 125.916, + 2285.025, + 1427.647, + 669.2930000000001 + ], + "priority": 9, + "parents": [ + 168652 + ], + "children": [], + "area": 287721.2079, + "iscrowd": 0, + "segmentation": [], + "text": "39 subjects (16 females; mean age of 23.2 years) participated in the study, divided\nin three equal groups for cathode, anode and sham stimulation.\n\nSubjects were seated in a sound-attenuated dark room. The eyes of the subjects\nwere 57 cm away from the computer screen.\n\nThe stimulus set contained 200 standardized, achromatic images. Visual stimuli\nwere modified to selectively stimulate MP (<0.9 cycles per degree) or PP\n(>4.7 cycles per degree). Participants were required to make decisions of object size,\nwhether the object they were shown was bigger or smaller than a shoebox.\n\nThere were two experimental sessions. Between the two tests tDCS was applied to\nmodulate the prefrontal cortical activity. The centre of the active tDCS electrode\n(surface: 5x7 cm) was over the OFC cortex (putative Fpz), while the other was over\nthe vertex. Stimulation was applied for 20 minutes with 1mA current intensity.\nSham stimulation was used as a control condition." + }, + { + "id": 168662, + "strid": "6fd89036-71ef-43a4-9884-b460fb20e8b3", + "image_id": 207089, + "image_name": "6950.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1572.527, + 2284.515, + 529.935, + 673.8939999999998 + ], + "priority": 10, + "parents": [ + 168652 + ], + "children": [], + "area": 3592461.519405, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 168663, + "strid": "27087c0a-3eba-4745-aff4-b4ad76f23e66", + "image_id": 207089, + "image_name": "6950.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 134.472, + 3014.282, + 1961.026, + 560.4169999999999 + ], + "priority": 11, + "parents": [ + 168652 + ], + "children": [], + "area": 405336.5291040001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 168653, + "strid": "5f0f2c98-7495-4944-beee-24d48f0bc3fe", + "image_id": 207089, + "image_name": "6950.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 115.249, + 3611.474, + 161.81700000000004, + 41.95699999999988 + ], + "priority": 12, + "parents": [ + 168666 + ], + "children": [ + 168665, + 168664, + 168660, + 168658 + ], + "area": 416218.767026, + "iscrowd": 0, + "segmentation": [], + "text": "Results:" + }, + { + "id": 168664, + "strid": "b0cf205a-d726-44fd-82a2-50ce29b57ebe", + "image_id": 207089, + "image_name": "6950.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 131.57, + 3733.853, + 563.636, + 447.8819999999996 + ], + "priority": 13, + "parents": [ + 168653 + ], + "children": [], + "area": 491263.03920999996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 168658, + "strid": "e61a2abe-f3c7-4125-a03c-394e7de8712c", + "image_id": 207089, + "image_name": "6950.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 732.589, + 3712.764, + 1389.4230000000002, + 141.23700000000008 + ], + "priority": 14, + "parents": [ + 168653 + ], + "children": [], + "area": 2719930.065996, + "iscrowd": 0, + "segmentation": [], + "text": "Before the stimulation the three groups were doing the task under identical\nconditions. The decisions about stimuli optimised for MP yielded shorter\nresponse latency times (RT) than latency times for PP stimuli (n=39, p<0.01)." + }, + { + "id": 168660, + "strid": "b36067b0-891b-4004-bd39-520cd16755c7", + "image_id": 207089, + "image_name": "6950.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 730.818, + 3885.324, + 1392.311, + 249.06600000000026 + ], + "priority": 15, + "parents": [ + 168653 + ], + "children": [], + "area": 2839464.715032, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 168665, + "strid": "02864ed2-40c3-4c3f-80fd-d08446b72e16", + "image_id": 207089, + "image_name": "6950.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 94.891, + 4213.054, + 1779.852, + 482.77400000000034 + ], + "priority": 16, + "parents": [ + 168653 + ], + "children": [], + "area": 399780.90711400006, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 168654, + "strid": "e20f8708-bcd8-496d-8d43-4bbfb13b1b21", + "image_id": 207089, + "image_name": "6950.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2196.157, + 2192.987, + 216.15599999999995, + 41.35600000000022 + ], + "priority": 17, + "parents": [ + 168666 + ], + "children": [ + 168659 + ], + "area": 4816143.750959001, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion" + }, + { + "id": 168659, + "strid": "83c28736-fe26-4b29-bf80-5cc070c49ddb", + "image_id": 207089, + "image_name": "6950.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2196.191, + 2290.588, + 1241.8689999999997, + 2026.2229999999995 + ], + "priority": 18, + "parents": [ + 168654 + ], + "children": [], + "area": 5030568.750308, + "iscrowd": 0, + "segmentation": [], + "text": "The rationale behind our study was the observation, that\npredictions might accelerate the perception of our environment by\npriming bottom-up processing. Most studies agree, that the\nphenomenon is based on information carried by the MP. It is not\nclear, however, what is the neuronal basis of fast visual\ncategorisation which provides a first impression about objects\nsurrounding us: is it MP information processed simultaneously with\nPP information or information arriving from the OFC via the MP?\n\nWe used tDCS to modify the operation of the OFC. The method\nconsists of a weak current flowing through the brain using two large\nsurface electrodes which can influence the membrane potential of\nlocal neurons. Cathode stimulation would hyperpolarise the\nmembrane, thus decreasing firing activity, while anodal stimulation\nwould have the opposite effect.\n\nWhen interpreting our results, one should consider that the\narrangement of electrodes for modulating the OFC is stimulating the\nmotor cortex when cathode stimulation is used, but inhibits it\nduring anodal stimulation. For this reason the effect of stimulation\ncan be studied only by analysing performance using pathway-\nspecialised stimuli.\n\nWe found that stimulation did not bias the accuracy of decision of\nstimuli optimized for the PP.\n\nIn case of stimuli optimized for the MP, cathode stimulation\ndecreased the subjects’ performance, whereas the anodal\nstimulation increased their performance. These results support the\npossibility of the top-down model, which can decrease the\nprocessing time by limiting the number of possible interpretations.\n\nThese results support the hypothesis of the top-down mechanisms,\nbut do not exclude the possibility of parallel processing of the PP\nand the MP informations.\n\nIt is still unclear which way the information reaches the OFC. We\nplan further studies to answer this question as well as to examine\nthe role of the magnocellular fibers running parallel to the ventral\nstream." + }, + { + "id": 111737, + "strid": "acb6604d-ae69-45d8-bee6-a7ff83f18fb5", + "image_id": 204838, + "image_name": "13243.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 268.61, + 359.42, + 301.17999999999995, + 370.67 + ], + "priority": -1, + "parents": [], + "children": [ + 111722, + 111721, + 111724, + 111723, + 111717, + 111718, + 111719, + 111720 + ], + "area": 96543.8062, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 111717, + "strid": "03f0aef4-cb94-46df-abab-6649afda1b73", + "image_id": 204838, + "image_name": "13243.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 857.289, + 27.029, + 3096.843, + 482.903 + ], + "priority": 1, + "parents": [ + 111737 + ], + "children": [], + "area": 23171.664381, + "iscrowd": 0, + "segmentation": [], + "text": "Identification of Potential Rodent Reservoirs of\nPathogenic Bartonella Species in a\nRestored Prairie Ecosystem" + }, + { + "id": 111718, + "strid": "0759e23e-5c60-4875-88d8-46142a39a752", + "image_id": 204838, + "image_name": "13243.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 903.625, + 532.687, + 3004.605, + 181.65099999999995 + ], + "priority": 2, + "parents": [ + 111737 + ], + "children": [], + "area": 481349.290375, + "iscrowd": 0, + "segmentation": [], + "text": "Sean Beckmann, PhD, Fernanda Chavez, & Malcolm Engelbrecht\nRockford University, Department of Biological & Chemical Sciences, Rockford, IL. 61108" + }, + { + "id": 111719, + "strid": "e10e001b-4e6f-4f5f-8be0-3382741ade50", + "image_id": 204838, + "image_name": "13243.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 336.778, + 809.614, + 380.433, + 57.716999999999985 + ], + "priority": 3, + "parents": [ + 111737 + ], + "children": [ + 111736 + ], + "area": 272660.18369200005, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 111736, + "strid": "31733775-7536-4ec3-8668-3e2c7bc062ea", + "image_id": 204838, + "image_name": "13243.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 52.301, + 907.136, + 948.184, + 1068.447 + ], + "priority": 4, + "parents": [ + 111719 + ], + "children": [], + "area": 47444.119936, + "iscrowd": 0, + "segmentation": [], + "text": "Bartonella is a genus of gram negative bacteria which\nincludes several human and veterinary pathogens.\nFollowing colonization of the endothelial cells of blood and\nlymphatic capillaries, the bacteria cause subsequent\ndiseases such as cat scratch disease, trench fever, and\nendocarditis. Due to an increase in identified Bartonella\ncases, specifically in humans, there has been an emphasis\non research focusing on this bacteria and its transmission\n(Bai et. al., 2007).\n\nMany Bartonella species are zoonotic, transmission occurs\nfrom reservoirs to terminal hosts via arthropod vectors\nincluding: ticks, fleas, mosquitoes, lice, and sand flies\n(Dehio 2004). Ticks are hypothesized to be the primary\nvectors of Bartonella infection, however vertical\ntransmission is rare (Billeter et al., 2008; Pulliainen &\nDehio, 2012). Ticks acquire the bacteria when feeding on an\ninfected host and subsequently transmit it to another\norganism during their next blood meal. Little is known\nhowever about which animals serve as reservoirs of these\npathogen. This study sought to determine if prairie\ndependent small mammals represent potential reservoirs of\nBartonella in Illinois." + }, + { + "id": 111720, + "strid": "edf51295-fb12-484b-8091-62fa33ae192b", + "image_id": 204838, + "image_name": "13243.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 394.044, + 2033.62, + 267.005, + 59.833000000000084 + ], + "priority": 5, + "parents": [ + 111737 + ], + "children": [ + 111735 + ], + "area": 801335.7592799999, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 111735, + "strid": "fcc09e5e-fe13-4c72-aaa9-84b2aea501ea", + "image_id": 204838, + "image_name": "13243.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 55.395, + 2126.974, + 947.211, + 424.6579999999999 + ], + "priority": 6, + "parents": [ + 111720 + ], + "children": [], + "area": 117823.72473000002, + "iscrowd": 0, + "segmentation": [], + "text": "From 2015-2017, small mammals were captured and\nidentified to species at Distillery Road Conservation Area in\nBoone County, IL. Tissue samples were collected from each\nanimal and tested for the presence of Bartonella spp via\nPCR of 16S-23S rRNA intergenic region using Bartonella\nspecific primers. Both overall and interannual infection\nrates were calculated and compared in order to identify\npotential disease reservoirs and look for any significant\nchanges in the prevalence of Bartonella." + }, + { + "id": 111721, + "strid": "0ce74c64-1074-4606-9bc0-331b23c46516", + "image_id": 204838, + "image_name": "13243.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 415.113, + 2608.188, + 226.23499999999996, + 60.389000000000124 + ], + "priority": 7, + "parents": [ + 111737 + ], + "children": [ + 111731, + 111733, + 111734, + 111732 + ], + "area": 1082692.745244, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 111734, + "strid": "398a489e-871f-4239-85dd-ffb1befc6348", + "image_id": 204838, + "image_name": "13243.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 58.745, + 2703.534, + 928.014, + 817.8209999999999 + ], + "priority": 8, + "parents": [ + 111721 + ], + "children": [], + "area": 158819.10483, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 111731, + "strid": "2ddd613f-8679-408a-8d10-1b81a70e472f", + "image_id": 204838, + "image_name": "13243.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1069.147, + 809.102, + 1352.8959999999997, + 1262.4850000000001 + ], + "priority": 9, + "parents": [ + 111721 + ], + "children": [ + 111728 + ], + "area": 865048.975994, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 111728, + "strid": "70411fa8-b8eb-41c2-899e-a9a1b1251e33", + "image_id": 204838, + "image_name": "13243.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1107.935, + 2100.603, + 1260.2940000000003, + 121.47400000000016 + ], + "priority": 10, + "parents": [ + 111731 + ], + "children": [], + "area": 2327331.584805, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. Distillery Road Conservation Area with locations\nof trapping grids are indicated by A and B." + }, + { + "id": 111732, + "strid": "ef0b78a0-bb2f-46fc-b661-d7c05d5e52ed", + "image_id": 204838, + "image_name": "13243.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2439.979, + 809.027, + 1361.8290000000002, + 1262.3890000000001 + ], + "priority": 11, + "parents": [ + 111721 + ], + "children": [ + 111729 + ], + "area": 1974008.890433, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 111729, + "strid": "7302101d-32bd-49dd-8080-a30d731f09d5", + "image_id": 204838, + "image_name": "13243.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2446.286, + 2090.809, + 1336.5010000000002, + 230.5680000000002 + ], + "priority": 12, + "parents": [ + 111732 + ], + "children": [], + "area": 5114716.785374001, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2.1% agarose gel of PCR products from Bartonella\namplification. Lane 9 represents a positive sample with a band\nat ~150bp. Lanes 13 and 14 contain positive and negative\ncontrols." + }, + { + "id": 111733, + "strid": "f05ade12-25ba-484f-ab04-1ae209f1355f", + "image_id": 204838, + "image_name": "13243.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1291.895, + 2329.425, + 2287.206, + 1110.3469999999998 + ], + "priority": 13, + "parents": [ + 111721 + ], + "children": [ + 111730 + ], + "area": 3009372.510375, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 111730, + "strid": "a5fc8c28-a031-422d-9a80-83f28f14c4f6", + "image_id": 204838, + "image_name": "13243.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1643.998, + 3474.373, + 1578.214, + 55.03800000000001 + ], + "priority": 14, + "parents": [ + 111733 + ], + "children": [], + "area": 5711862.263254, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3: Percentage of species positive for Bartonella by species and year." + }, + { + "id": 111724, + "strid": "334aac4f-a260-467d-b00e-762a83328e90", + "image_id": 204838, + "image_name": "13243.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4129.889, + 814.04, + 365.8239999999996, + 59.585000000000036 + ], + "priority": 15, + "parents": [ + 111737 + ], + "children": [ + 111727 + ], + "area": 3361894.84156, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 111727, + "strid": "ac95daa0-8524-4008-88bc-b3fc2f51564f", + "image_id": 204838, + "image_name": "13243.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3887.069, + 914.164, + 852.2689999999998, + 1020.71 + ], + "priority": 16, + "parents": [ + 111724 + ], + "children": [], + "area": 3553418.545316, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 111722, + "strid": "e20003df-d297-4e87-bc76-cfebcb9f28cb", + "image_id": 204838, + "image_name": "13243.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4022.11, + 3102.648, + 581.2459999999996, + 73.23300000000017 + ], + "priority": 17, + "parents": [ + 111737 + ], + "children": [ + 111725 + ], + "area": 12479191.54728, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements" + }, + { + "id": 111725, + "strid": "f36608c5-ca1e-41fb-9926-984372a8e98f", + "image_id": 204838, + "image_name": "13243.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3909.24, + 3205.458, + 811.6840000000002, + 324.6170000000002 + ], + "priority": 18, + "parents": [ + 111722 + ], + "children": [], + "area": 12530904.63192, + "iscrowd": 0, + "segmentation": [], + "text": "The authors would like to thank the Rockford\nUniversity Student-Faculty Summer Research grant\nprogram for research funding, the Student\nOpportunity Fund for conference support, and the\nBoone County Conservation District and Illinois\nDepartment of Natural Resources for permits and\nsupport." + }, + { + "id": 111723, + "strid": "8c605101-58e3-40cd-a46c-d3710d098d86", + "image_id": 204838, + "image_name": "13243.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4064.137, + 2001.604, + 497.4169999999999, + 63.58600000000001 + ], + "priority": 19, + "parents": [ + 111737 + ], + "children": [ + 111726 + ], + "area": 8134792.875748, + "iscrowd": 0, + "segmentation": [], + "text": "Literature Cited" + }, + { + "id": 111726, + "strid": "1d0b9d53-aa35-4090-89b3-b9791b9a7adc", + "image_id": 204838, + "image_name": "13243.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3889.463, + 2103.674, + 829.4999999999995, + 926.5889999999999 + ], + "priority": 20, + "parents": [ + 111723 + ], + "children": [], + "area": 8182162.187062, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 77129, + "strid": "6b777c91-6213-4128-8649-e3ee9b9b0fe8", + "image_id": 203509, + "image_name": "120360.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 43.27, + 60.76, + 102.69, + 179.70000000000002 + ], + "priority": -1, + "parents": [], + "children": [ + 77111, + 77113, + 77112, + 77121, + 77109, + 77118, + 77110, + 77126 + ], + "area": 2629.0852, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 77112, + "strid": "ab7af728-36f6-4c54-a6be-679b80885a60", + "image_id": 203509, + "image_name": "120360.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 217.017, + 30.617, + 2734.76, + 186.466 + ], + "priority": 1, + "parents": [ + 77129 + ], + "children": [], + "area": 6644.409489, + "iscrowd": 0, + "segmentation": [], + "text": "Detection of isoniazid-resistant Mycobacterium tuberculosis\nby padlock probes combined with lateral flow nucleic acid biosensor" + }, + { + "id": 77113, + "strid": "f006d37c-11c3-4150-9b4d-9f9eecd59d9d", + "image_id": 203509, + "image_name": "120360.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 163.429, + 313.6, + 2831.262, + 135.26300000000003 + ], + "priority": 2, + "parents": [ + 77129 + ], + "children": [], + "area": 51251.33440000001, + "iscrowd": 0, + "segmentation": [], + "text": "Asalapuram R. Pavankumar, Anna Engstrom, Jie Liu#, David Herthnek, Mats Niisson*\nScience for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden" + }, + { + "id": 77109, + "strid": "59f208aa-2f1c-48cc-afeb-fc925538e627", + "image_id": 203509, + "image_name": "120360.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 540.683, + 508.855, + 412.751, + 65.62599999999998 + ], + "priority": 3, + "parents": [ + 77129 + ], + "children": [ + 77116 + ], + "area": 275129.247965, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 77116, + "strid": "a1279ca1-eec4-44d5-bd72-810ae4657e1f", + "image_id": 203509, + "image_name": "120360.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 5.896, + 583.628, + 1480.191, + 614.6439999999999 + ], + "priority": 4, + "parents": [ + 77109 + ], + "children": [], + "area": 3441.0706880000002, + "iscrowd": 0, + "segmentation": [], + "text": "Correct identification of isoniazid (INH)-resistant Mycobacterium\ntuberculosis among other \\multidrug-resistant strains could\nimmensely help the treatment process. Our molecular method;\nusing padlock probes (RLPs) can discriminate single-nucleotide\nvariants and concretely distinguish wild type (WT) and_mutants\n(MUT) by ligation-dependent rolling circle amplification (RCA; 1).\nCombining thissstringent assay with sensitive lateratflow nucleic\nacid biosensors (LFNAB) could be a promising approach for\ndevelopment of simple and rapid diagnostics (2) for the\ndetection of drug-resistant tuberculosis." + }, + { + "id": 77111, + "strid": "32f37f42-b428-4aaf-87b6-50826aaa5a50", + "image_id": 203509, + "image_name": "120360.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 597.674, + 1229.011, + 293.58899999999994, + 69.07999999999993 + ], + "priority": 5, + "parents": [ + 77129 + ], + "children": [ + 77117 + ], + "area": 734547.9204139999, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 77117, + "strid": "cabb912e-9ee9-4e2c-ab28-1b5202573ec4", + "image_id": 203509, + "image_name": "120360.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 12.533, + 1319.077, + 1470.898, + 431.44600000000014 + ], + "priority": 6, + "parents": [ + 77111 + ], + "children": [], + "area": 16531.992040999998, + "iscrowd": 0, + "segmentation": [], + "text": "PLPs were designed to detect INH-resistant M. tuberculosis by\ntargeting the katG gene at codon’315 (WT AGC and MUT ACC).\nBiotinylated oligonucleotide, tags complimentary to the WT and\nMUT monomers were immobilized on lateral flow strips (LFS).\nOligonucleotides conjugated with gold nanoparticles (AuNPs)\nwere hybridized to the “monomers and visualized on LFS» to\ndetermine WT and/or-MUT genotypes." + }, + { + "id": 77110, + "strid": "f9328883-28c3-47a1-bcd8-b3bfa81253b7", + "image_id": 203509, + "image_name": "120360.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2184.78, + 503.674, + 302.22400000000016, + 77.71500000000003 + ], + "priority": 7, + "parents": [ + 77129 + ], + "children": [ + 77114 + ], + "area": 1100416.88172, + "iscrowd": 0, + "segmentation": [], + "text": "Principle" + }, + { + "id": 77114, + "strid": "343ee0ff-4526-4630-a24b-e7d2b6d73be4", + "image_id": 203509, + "image_name": "120360.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1515.535, + 603.955, + 1623.39, + 1652.2940000000003 + ], + "priority": 8, + "parents": [ + 77110 + ], + "children": [ + 77115 + ], + "area": 915314.9409250001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 77115, + "strid": "247789aa-42f5-4bd9-a739-865d33ddf730", + "image_id": 203509, + "image_name": "120360.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 9.55, + 1775.93, + 1475.306, + 500.9480000000001 + ], + "priority": 9, + "parents": [ + 77114 + ], + "children": [], + "area": 16960.131500000003, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. Padlock probes, rolling circle amplification andAateral flow\nnucleic acid biosensors.\n\nThe backbone\\(grey) of the PLP contains detection and.restriction sites, while\nthe 5’ and‘3’yarms (black) are designed to hybridize.to the target sequence\n(orange;sFig. 1A). Upon matched hybridization, the circularized probes undergo\nRCA “and amplicons are digested using a restriction-oligo in the presence of\nAlulithe products are again amplified (circle-to-circle amplification; 3) and the\nmonomers are hybridized to tags that are conjugated to AuNPs and these\ncomplexes specifically bind to WT or MUA. tags immobilized on the LFS and\nproduce visual signals (Fig. 1B)." + }, + { + "id": 77118, + "strid": "6c84f18e-144c-4184-9819-e3295fabba37", + "image_id": 203509, + "image_name": "120360.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1446.486, + 2315.074, + 255.33500000000004, + 63.16199999999981 + ], + "priority": 10, + "parents": [ + 77129 + ], + "children": [ + 77125, + 77124, + 77122, + 77123 + ], + "area": 3348722.1299640005, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 77123, + "strid": "85c90029-205a-42ee-a630-061a022b7dc6", + "image_id": 203509, + "image_name": "120360.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 53.781, + 2401.863, + 923.135, + 61.541999999999916 + ], + "priority": 11, + "parents": [ + 77118 + ], + "children": [], + "area": 129174.59400299999, + "iscrowd": 0, + "segmentation": [], + "text": "Limit of detection of RCA-LFNAB assay" + }, + { + "id": 77122, + "strid": "c6bee0c6-7dc4-424a-8ff6-cf24e3f3f2fd", + "image_id": 203509, + "image_name": "120360.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 63.498, + 2502.274, + 801.67, + 743.3669999999997 + ], + "priority": 12, + "parents": [ + 77118 + ], + "children": [ + 77119 + ], + "area": 158889.39445199998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 77119, + "strid": "c2fe49c8-e7cf-41f7-b121-7d5a5dfb1bd5", + "image_id": 203509, + "image_name": "120360.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 916.682, + 2619.3, + 1175.8839999999998, + 203.17999999999984 + ], + "priority": 13, + "parents": [ + 77122 + ], + "children": [], + "area": 2401065.1626000004, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2. Limit of\\detection of RCA-LFNAB test.\n\nDifferent amounts of WT genomic M. tuberculosis DNA were\ndetected by RCA and visualized by LFNAB (Fig. 2A)The\nintensity.of signals are quantitatively represented in Fig 2B." + }, + { + "id": 77124, + "strid": "a01a20db-d5ad-4c6e-a7b9-ce97545e5d4a", + "image_id": 203509, + "image_name": "120360.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2056.787, + 2399.182, + 1036.1460000000002, + 113.1239999999998 + ], + "priority": 14, + "parents": [ + 77118 + ], + "children": [], + "area": 4934606.348233999, + "iscrowd": 0, + "segmentation": [], + "text": "Visualdetection of INH resistance in\nMycobacterium tuberculosis by RCA-LFNAB" + }, + { + "id": 77125, + "strid": "b293e62c-4d98-4636-8992-c699b5acb223", + "image_id": 203509, + "image_name": "120360.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2119.087, + 2523.782, + 980.404, + 724.6459999999997 + ], + "priority": 15, + "parents": [ + 77118 + ], + "children": [ + 77120 + ], + "area": 5348113.627034, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 77120, + "strid": "72abe63f-7aa8-40a0-9b6b-abcf75eae530", + "image_id": 203509, + "image_name": "120360.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 918.282, + 2870.475, + 1174.284, + 355.16499999999996 + ], + "priority": 16, + "parents": [ + 77125 + ], + "children": [], + "area": 2635905.52395, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3. Visual detection of INH-resistant and susceptible\nphenotypes of M. tuberculosis.\n\nSixteen clinical strains were analyzed and their genotypes were\ncorrectly detected, using 10 amol (30ng) of DNA. Fig. 3A\nrepresents the consistent identification of WT and MUT\ngenotypes on LFS. For clarity, Only the band intensities of\nstrains WT#1 and MUT#1 are given in the Fig. 3B." + }, + { + "id": 77121, + "strid": "acedc9d5-a3b9-48ab-a5cf-b8ddd49b559d", + "image_id": 203509, + "image_name": "120360.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 841.49, + 3265.636, + 387.16200000000003, + 68.79300000000012 + ], + "priority": 17, + "parents": [ + 77129 + ], + "children": [ + 77128 + ], + "area": 2748000.03764, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion" + }, + { + "id": 77128, + "strid": "045959fc-d79e-44a0-ad97-303dd395eb86", + "image_id": 203509, + "image_name": "120360.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4.169, + 3358.273, + 2055.897, + 239.36299999999983 + ], + "priority": 18, + "parents": [ + 77121 + ], + "children": [], + "area": 14000.640136999999, + "iscrowd": 0, + "segmentation": [], + "text": "PLPs, RCA and LFNAB were used to develop a simple, cost-effective and rapid molecular\nmethod for the detection of INH-resistant M. tuberculosis strains. By this method, WT\nkatG gene codon’ 315 and its mutant (315 ACC) canbe detected and visualized in ~70\nmin. The test can be expanded for the detection of multidrug-resistant M. tuberculosis." + }, + { + "id": 77126, + "strid": "eb6ee873-1cc9-40c0-879e-095b95a83a59", + "image_id": 203509, + "image_name": "120360.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2442.063, + 3268.102, + 380.35699999999997, + 62.30000000000018 + ], + "priority": 19, + "parents": [ + 77129 + ], + "children": [ + 77127 + ], + "area": 7980910.974426, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 77127, + "strid": "175ab61c-e17e-45fa-8cf2-5223ea82050a", + "image_id": 203509, + "image_name": "120360.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2120.726, + 3368.11, + 750.8780000000002, + 126.23900000000003 + ], + "priority": 20, + "parents": [ + 77126 + ], + "children": [], + "area": 7142838.447860001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 151128, + "strid": "17d8269c-7fd0-46eb-8260-27611c1e0017", + "image_id": 206377, + "image_name": "21182.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 2457.88, + 181.5, + 237.75, + 277.37 + ], + "priority": -1, + "parents": [], + "children": [ + 151112, + 151114, + 151119, + 151113 + ], + "area": 446105.22000000003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 151112, + "strid": "3173a0d1-c22f-4c1a-813d-ad742370a344", + "image_id": 206377, + "image_name": "21182.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 169.349, + 128.967, + 2106.757, + 479.289 + ], + "priority": 1, + "parents": [ + 151128 + ], + "children": [], + "area": 21840.432483, + "iscrowd": 0, + "segmentation": [], + "text": "Predicting EDC mode of action\nfrom toxicogenomics data\nusing EDTox" + }, + { + "id": 151113, + "strid": "af8fabad-62a3-4eb3-bdc7-371a2698b85a", + "image_id": 206377, + "image_name": "21182.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 174.945, + 638.477, + 2897.061, + 291.69500000000005 + ], + "priority": 2, + "parents": [ + 151128 + ], + "children": [], + "area": 111698.358765, + "iscrowd": 0, + "segmentation": [], + "text": "Arindam Ghosh’, Amirhossein Sakhteman’, Raghavendra Mysore’, Einari Niskanen’, Thomas A.\nDarde2, Pierre Daligaux?, Christophe Chesné2, Jorma J. Palvimo’, Vittorio Fortino'\n\n'Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland\n\n? Eurosafe, Saint Grégoire, France" + }, + { + "id": 151114, + "strid": "95c3f9af-0f22-4418-b2fc-1861929ffd6c", + "image_id": 206377, + "image_name": "21182.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 181.917, + 969.377, + 292.66999999999996, + 40.761999999999944 + ], + "priority": 3, + "parents": [ + 151128 + ], + "children": [ + 151126, + 151123, + 151116, + 151124, + 151115, + 151117, + 151125, + 151127 + ], + "area": 176346.15570899998, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 151115, + "strid": "e06319ce-0475-4a53-ac25-270fa5949a4b", + "image_id": 206377, + "image_name": "21182.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 182.061, + 1071.55, + 1973.0450000000003, + 901.1960000000001 + ], + "priority": 4, + "parents": [ + 151114 + ], + "children": [], + "area": 195087.46455, + "iscrowd": 0, + "segmentation": [], + "text": "Endocrine disrupting chemicals (EDCs) are a class of chemicals that have the potential to alter\nthe normal functioning of the endocrine system by mimicking, blocking, or interfering with the\nhormones of the system. Even though many of the potential effects of exposure to these\ncompounds are well known, their precise mode of action (MOA) is still not predictable. EDTox\noffers an easy-to-use web interface (http://edtox.fi/) and standalone R-Shiny application for\ntraining classifiers for prioritization of chemicals based on their endocrine disruption potential\nand identification of the possible MoAs. EDTox utilizes known chemical-gene interactions\ntogether with toxicogenomic data driven gene networks to train a binary classifier. The use of\ngeneralised linear models (GLM) in EDTox provides a way for identification of the features that\nare responsible for distinguishing the EDCs from non-EDCs and can be used for predicting the\npossible MoAs of the EDCs. Currently, EDTox includes classifiers based on toxicogenomics data\nfrom Open TG-Gates, DrugMatrix and LINCS that can be used for compiling the ED probability\nscores for chemicals by entering the list of genes that interact with the chemical. Here, we use\ngene expression data from HepG2 and HepaRG cell lines exposed to EDCs to train new\nclassifiers and identify their potential MoAs. In particular, we observed that the effects of EDCs\nare mediated through different pathways under different conditions and that they also vary\nbetween doses." + }, + { + "id": 151116, + "strid": "1768e760-fe94-49bf-a735-c2949d03098b", + "image_id": 206377, + "image_name": "21182.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2223.565, + 998.673, + 838.9470000000001, + 1250.711 + ], + "priority": 5, + "parents": [ + 151114 + ], + "children": [], + "area": 2220614.329245, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 151125, + "strid": "db70528f-b427-45db-b263-44627d06cf45", + "image_id": 206377, + "image_name": "21182.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 205.178, + 2008.394, + 1433.4450000000002, + 788.961 + ], + "priority": 6, + "parents": [ + 151114 + ], + "children": [ + 151121 + ], + "area": 412078.264132, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 151121, + "strid": "2544656b-ffb6-4358-8172-6a101a2830d1", + "image_id": 206377, + "image_name": "21182.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 206.284, + 2818.791, + 1288.181, + 46.391999999999825 + ], + "priority": 7, + "parents": [ + 151125 + ], + "children": [], + "area": 581471.482644, + "iscrowd": 0, + "segmentation": [], + "text": "Fig: EDTox tab used for training classifier from toxicogenomic data" + }, + { + "id": 151124, + "strid": "bf92d346-8106-4197-a9c6-c9cd9d241342", + "image_id": 206377, + "image_name": "21182.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 190.42, + 2903.019, + 1496.762, + 272.1329999999998 + ], + "priority": 8, + "parents": [ + 151114 + ], + "children": [], + "area": 552792.8779799999, + "iscrowd": 0, + "segmentation": [], + "text": "Use case data:\n\nEDCs: TPP/TPHP; DEHP; TDCPP; TBT; Carbofuran; 3OH-Carbofuran;\nPFOS*: Atrazine; PCB 118; PFOA; PCB 153; MEHP; Cypermethrin; DES;\nPropiconazole; DDE; BPA; Dexamethazone™; GW7647**; GW3965**;\nCITCO**: GW4064**" + }, + { + "id": 151126, + "strid": "14bb64b6-1769-4eb9-ad9c-171db2688fb7", + "image_id": 206377, + "image_name": "21182.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 196.054, + 3196.317, + 1490.507, + 50.36400000000003 + ], + "priority": 9, + "parents": [ + 151114 + ], + "children": [], + "area": 626650.733118, + "iscrowd": 0, + "segmentation": [], + "text": "Doses: HepG2: variable dose for each EDC; HepaRG: 1nM, 100nM, 10uUM" + }, + { + "id": 151127, + "strid": "074b5e7d-cf32-44e2-bf32-57614c97b9a3", + "image_id": 206377, + "image_name": "21182.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 192.247, + 3264.131, + 807.0329999999999, + 103.875 + ], + "priority": 10, + "parents": [ + 151114 + ], + "children": [], + "area": 627519.392357, + "iscrowd": 0, + "segmentation": [], + "text": "Time points: 24 h in both experiments\n[Note: * Not used in HepG2; ** Used only in HepG2]" + }, + { + "id": 151117, + "strid": "7893bace-1a22-4219-b141-2dad8c290c21", + "image_id": 206377, + "image_name": "21182.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1739.907, + 2417.943, + 1455.8390000000002, + 871.893 + ], + "priority": 11, + "parents": [ + 151114 + ], + "children": [ + 151118 + ], + "area": 4206995.951301, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 151118, + "strid": "fe8ab99a-f547-43a7-a819-c79b78635ff8", + "image_id": 206377, + "image_name": "21182.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1741.058, + 3311.41, + 1454.1130000000003, + 199.92299999999977 + ], + "priority": 12, + "parents": [ + 151117 + ], + "children": [], + "area": 5765356.87178, + "iscrowd": 0, + "segmentation": [], + "text": "Fig: Systematic comparison of average pathway activation scores and\nGLM coefficients of pathways for different classifiers. The specific MoA of\ncompounds under different exposure scenarios can be identified by\nexploring the differences in activated pathways." + }, + { + "id": 151123, + "strid": "eb3479a2-a375-4ffa-8044-7032d8b711d9", + "image_id": 206377, + "image_name": "21182.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 172.336, + 3416.605, + 1523.383, + 782.511 + ], + "priority": 13, + "parents": [ + 151114 + ], + "children": [ + 151122 + ], + "area": 588804.03928, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 151122, + "strid": "8e7157ce-6ac6-467e-a03d-f2fedb5ab852", + "image_id": 206377, + "image_name": "21182.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 171.064, + 4210.004, + 1440.427, + 95.13299999999981 + ], + "priority": 14, + "parents": [ + 151123 + ], + "children": [], + "area": 720180.1242559999, + "iscrowd": 0, + "segmentation": [], + "text": "Fig: Comparison of accuracies of the newly trained classifiers with the pre-\ntrained classifiers in EDTox" + }, + { + "id": 151119, + "strid": "39eef171-afb0-4605-8c2c-178612ab6829", + "image_id": 206377, + "image_name": "21182.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1776.171, + 3587.736, + 325.37099999999987, + 46.05699999999979 + ], + "priority": 15, + "parents": [ + 151128 + ], + "children": [ + 151120 + ], + "area": 6372432.638856, + "iscrowd": 0, + "segmentation": [], + "text": "Key outcomes" + }, + { + "id": 151120, + "strid": "dfbb8b13-ff7a-455e-985a-a9e018cc3c40", + "image_id": 206377, + "image_name": "21182.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1776.544, + 3689.761, + 1363.6270000000002, + 480.0269999999996 + ], + "priority": 16, + "parents": [ + 151119 + ], + "children": [], + "area": 6555022.765984001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 167433, + "strid": "7baf5ca6-b526-4dfc-89ce-26d5cbf90617", + "image_id": 207037, + "image_name": "6818.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 29.26, + 60.07, + 162.63, + 199.59000000000003 + ], + "priority": -1, + "parents": [], + "children": [ + 167412, + 167411, + 167413, + 167415, + 167416, + 167410, + 167414 + ], + "area": 1757.6482, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 167410, + "strid": "7e881da8-9e45-4f87-9922-0bbad5e1987e", + "image_id": 207037, + "image_name": "6818.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 292.734, + 61.096, + 2364.044, + 203.00599999999997 + ], + "priority": 1, + "parents": [ + 167433 + ], + "children": [], + "area": 17884.876463999997, + "iscrowd": 0, + "segmentation": [], + "text": "On the Interest of Semi-Supervised Approaches with Spacial\nDependence in Structural Alphabet Encoding" + }, + { + "id": 167411, + "strid": "f7230b17-b1a5-4844-9103-4889737391f7", + "image_id": 207037, + "image_name": "6818.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 228.717, + 308.883, + 2583.345, + 300.5760000000001 + ], + "priority": 2, + "parents": [ + 167433 + ], + "children": [], + "area": 70646.793111, + "iscrowd": 0, + "segmentation": [], + "text": "Ikram ALLAM( 23), Delphine FLATTERS“), Leslie REGAD™), Anne-Claude CAMproux“) and Grégory NUEL®\n\n() MTi, UMR-S 973 INSERM, University Paris Diderot, France\n?) LPMA PSB, UMR 7599 CNRS, University Pierre et Marie Curie, France\n3) MAPS, UMR 8145 CNRS, University Paris Descartes, France" + }, + { + "id": 167412, + "strid": "98c83fa6-4aff-47f5-8441-ccb8d5dd8fca", + "image_id": 207037, + "image_name": "6818.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 452.676, + 716.389, + 728.626, + 68.50099999999998 + ], + "priority": 3, + "parents": [ + 167433 + ], + "children": [ + 167424, + 167423, + 167425 + ], + "area": 324292.106964, + "iscrowd": 0, + "segmentation": [], + "text": "Structural Alphabet (SA)" + }, + { + "id": 167424, + "strid": "1229e24c-fe19-49ec-b250-c0d81cb58f4c", + "image_id": 207037, + "image_name": "6818.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 83.103, + 858.357, + 1016.427, + 391.5140000000001 + ], + "priority": 4, + "parents": [ + 167412 + ], + "children": [], + "area": 71332.04177099999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 167423, + "strid": 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step: secondary structure predictions" + }, + { + "id": 167429, + "strid": "ac595d71-c0ce-457b-b017-bcef5ce7a2ec", + "image_id": 207037, + "image_name": "6818.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1693.076, + 944.36, + 709.0, + 370.5000000000001 + ], + "priority": 12, + "parents": [ + 167413 + ], + "children": [], + "area": 1598873.25136, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 167430, + "strid": "3f95145b-c5b9-424e-8e25-d24756e9183c", + "image_id": 207037, + "image_name": "6818.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1827.422, + 1325.553, + 221.471, + 96.25800000000004 + ], + "priority": 13, + "parents": [ + 167413 + ], + "children": [], + "area": 2422344.714366, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 167431, + "strid": "198cfd5f-637e-49a5-8129-ec6f0181c38d", + "image_id": 207037, + "image_name": "6818.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2103.13, + 1324.595, + 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Coil 047% 052% 083% 0.16%" + }, + { + "id": 167421, + "strid": "9db7838b-598a-4f19-8d51-88c52e367301", + "image_id": 207037, + "image_name": "6818.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1717.325, + 1525.787, + 1439.494, + 585.867 + ], + "priority": 16, + "parents": [ + 167413 + ], + "children": [], + "area": 2620272.159775, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 167432, + "strid": "bf64906f-fc54-4241-b602-ef6b1a196774", + "image_id": 207037, + "image_name": "6818.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1815.772, + 2145.034, + 1311.6660000000002, + 35.873999999999796 + ], + "priority": 17, + "parents": [ + 167413 + ], + "children": [], + "area": 3894892.676248, + "iscrowd": 0, + "segmentation": [], + "text": "HMM posterior distributions are much more accurate than their mixture model (MM) counterpart." + }, + { + "id": 167422, + "strid": "90bd7ffa-f449-4242-a20e-977792fbf813", + "image_id": 207037, + "image_name": "6818.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1761.333, + 2219.947, + 1488.429, + 1005.7730000000001 + ], + "priority": 18, + "parents": [ + 167413 + ], + "children": [], + "area": 3910065.9093510006, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 167415, + "strid": "001c6451-831c-47a7-b358-0605bbb8bc92", + "image_id": 207037, + "image_name": "6818.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2327.268, + 3286.053, + 327.62300000000005, + 64.25 + ], + "priority": 19, + "parents": [ + 167433 + ], + "children": [ + 167418, + 167419 + ], + "area": 7647525.9932039995, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion" + }, + { + "id": 167418, + "strid": "0594f03b-6a1e-4185-8d1f-7c04ff61d34d", + "image_id": 207037, + "image_name": "6818.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1741.244, + 3352.431, + 1507.8129999999999, + 206.712 + ], + "priority": 20, + "parents": [ + 167415 + ], + "children": [], + "area": 5837400.364163999, + "iscrowd": 0, + "segmentation": [], + "text": "As seen in tables above, maximum a posteriori (MAP) predictions have similar\nperformances for MM and HMM. But posterior probabilities are dramatically\nimproved using HMM by taking into account the spacial correlation between\nfragments." + }, + { + "id": 167419, + "strid": "0fc826a1-f2d3-43fd-8a45-c0ea4aaf65a9", + "image_id": 207037, + "image_name": "6818.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1742.792, + 3575.26, + 1505.8030000000003, + 161.4630000000002 + ], + "priority": 21, + "parents": [ + 167415 + ], + "children": [], + "area": 6230934.52592, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 167416, + "strid": "c52dcc00-9242-4729-ab80-ffed626f0c8e", + "image_id": 207037, + "image_name": "6818.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2345.105, + 3797.253, + 314.47699999999986, + 68.23700000000008 + ], + "priority": 22, + "parents": [ + 167433 + ], + "children": [ + 167420 + ], + "area": 8904956.996565001, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 167420, + "strid": "1b578936-8e6e-4d38-85ee-2d58fc6bd031", + "image_id": 207037, + "image_name": "6818.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1727.989, + 3869.903, + 1525.71, + 310.61799999999994 + ], + "priority": 23, + "parents": [ + 167416 + ], + "children": [], + "area": 6687149.815067, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 121372, + "strid": "1951675c-c4b5-4163-b80c-5eff082c12f8", + "image_id": 205225, + "image_name": "14469.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 849.62, + 247.45, + 226.89999999999998, + 167.91000000000003 + ], + "priority": -1, + "parents": [], + "children": [ + 121355, + 121364, + 121358, + 121352, + 121368, + 121351, + 121354, + 121366 + ], + "area": 210238.46899999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 121352, + "strid": "44257e8c-4561-427d-be4d-d165dc9c2beb", + "image_id": 205225, + "image_name": "14469.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 748.195, + 71.042, + 2513.409, + 137.184 + ], + "priority": 1, + "parents": [ + 121372 + ], + "children": [], + "area": 53153.269190000006, + "iscrowd": 0, + "segmentation": [], + "text": "LARGER ACCUMBENS VOLUME IS ASSOCIATED WITH INCREASED DRINKING BEHAVIOR\nAMONG ADOLESCENTS" + }, + { + "id": 121351, + "strid": "a7326ca0-a12e-4603-931e-a4a9319aa0ab", + "image_id": 205225, + "image_name": "14469.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1331.227, + 281.717, + 1332.646, + 161.68100000000004 + ], + "priority": 2, + "parents": [ + 121372 + ], + "children": [], + "area": 375029.27675900003, + "iscrowd": 0, + "segmentation": [], + "text": "S.M. Crotwell', T.J. Callahan?, K.E. Hutchison?, A.D. Bryan?\n\n‘University of New Mexico, Albuquerque, NM\n2University of Colorado, Boulder, CO" + }, + { + "id": 121354, + "strid": "a25f4849-47d5-459d-8f86-73df39211997", + "image_id": 205225, + "image_name": "14469.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 566.973, + 497.38, + 265.70000000000005, + 42.51200000000006 + ], + "priority": 3, + "parents": [ + 121372 + ], + "children": [ + 121353 + ], + "area": 282001.03073999996, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 121353, + "strid": "8a78dad1-6a0d-4d29-80e2-bedda7ae478d", + "image_id": 205225, + "image_name": "14469.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 88.712, + 573.902, + 1190.338, + 750.338 + ], + "priority": 4, + "parents": [ + 121354 + ], + "children": [], + "area": 50911.99422400001, + "iscrowd": 0, + "segmentation": [], + "text": "Among 15-18 year olds, 13.5% meet criteria for a lifetime\nalcohol use disorder (Warner, Canino, & Col6én, 2001). Galvan e\nal. (2006) found that subcortical regions (like the accumbens)\nare developed earlier in adolescence while top-down control\nregions (like medial frontal gyrus) mature later, biasing the\nadolescent’s judgment and decision-making. Much of addiction\nresearch on the association between neural structure and\nalcohol use has focused on individuals exposed to long-term\nuse, making it difficult to determine if any premorbid neural\ndifferences exist.\n\nThe purpose of the current study was to explore how\nneural structure, particularly volume of the nucleus accumbens,\nis associated with drinking behavior among adolescents. It was\nhypothesized that accumbens volume would be positively\ncorrelated with quantity and frequency of alcohol consumption." + }, + { + "id": 121358, + "strid": "3b320e9f-37c7-4388-a590-f876ad505e5f", + "image_id": 205225, + "image_name": "14469.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 603.109, + 1366.752, + 187.053, + 55.266000000000076 + ], + "priority": 5, + "parents": [ + 121372 + ], + "children": [ + 121360, + 121359, + 121361, + 121362 + ], + "area": 824300.431968, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 121359, + "strid": "071982ba-ccdb-4eec-b9b4-43808c67c54a", + "image_id": 205225, + "image_name": "14469.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 101.466, + 1466.655, + 1177.585, + 257.1980000000001 + ], + "priority": 6, + "parents": [ + 121358 + ], + "children": [], + "area": 148815.61622999999, + "iscrowd": 0, + "segmentation": [], + "text": "Participants: 220 adolescents (13-18 years old) were recruited\nfrom the juvenile justice system. The adolescents were\npredominately male (77%) and were ethnically diverse (63.2%\nHispanic/Latino, 14.5% Caucasian, 10% Mixed, 6.4% African\nAmerican, 4.1% American Indian, 1.4% Asian/Pacific Islander)." + }, + { + "id": 121360, + "strid": "d4760550-84bd-4186-bd78-e66f92f541b3", + "image_id": 205225, + "image_name": "14469.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 97.215, + 1762.114, + 1190.338, + 204.058 + ], + "priority": 7, + "parents": [ + 121358 + ], + "children": [], + "area": 171303.91251, + "iscrowd": 0, + "segmentation": [], + "text": "Volumetric Data: Each participant completed Magnetic\nResonance Imaging (MRI), and images were analyzed using\nFreeSurfer. Volume of nucleus accumbens, medial frontal gyrus\n(MFG), and cerebral cortex were computed." + }, + { + "id": 121361, + "strid": "1ad3eabc-c477-416d-9e4f-967d16c0af8c", + "image_id": 205225, + "image_name": "14469.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 92.963, + 2012.756, + 1196.715, + 102.02899999999977 + ], + "priority": 8, + "parents": [ + 121358 + ], + "children": [], + "area": 187111.836028, + "iscrowd": 0, + "segmentation": [], + "text": "Drinking Behavior: Drinking behavior was assessed using self-\nreport measures including:" + }, + { + "id": 121362, + "strid": "6da49dd0-14f4-4705-9cde-ecbdaa002e02", + "image_id": 205225, + "image_name": "14469.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 95.089, + 2117.09, + 1203.092, + 595.1689999999999 + ], + "priority": 9, + "parents": [ + 121358 + ], + "children": [], + "area": 201311.97101, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 121355, + "strid": "3a4f0774-ebca-4e90-bee4-db61bb0fa135", + "image_id": 205225, + "image_name": "14469.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1931.611, + 503.757, + 163.6719999999998, + 44.63799999999998 + ], + "priority": 10, + "parents": [ + 121372 + ], + "children": [ + 121371, + 121357, + 121363 + ], + "area": 973062.5625270001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 121357, + "strid": "7d4e39d4-7be6-4a42-8475-e142939033d7", + "image_id": 205225, + "image_name": "14469.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1444.848, + 648.298, + 1126.5699999999997, + 616.425 + ], + "priority": 11, + "parents": [ + 121355 + ], + "children": [ + 121356 + ], + "area": 936692.068704, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 121356, + "strid": "0d3813bd-c106-4590-94d5-b55eb73bf468", + "image_id": 205225, + "image_name": "14469.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1461.853, + 578.153, + 552.6570000000002, + 46.763000000000034 + ], + "priority": 12, + "parents": [ + 121357 + ], + "children": [], + "area": 845174.6975090001, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1. Gender Differences" + }, + { + "id": 121363, + "strid": "a2ed20a2-4066-4bbc-a2ac-661e3a63de0c", + "image_id": 205225, + "image_name": "14469.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1431.713, + 1310.204, + 1145.314, + 1407.7170000000003 + ], + "priority": 13, + "parents": [ + 121355 + ], + "children": [], + "area": 1875836.0994519999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 121371, + "strid": "56e9e35a-5e92-4298-84b8-315c2a2d74ec", + "image_id": 205225, + "image_name": "14469.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2751.164, + 502.707, + 995.4320000000002, + 774.9250000000001 + ], + "priority": 14, + "parents": [ + 121355 + ], + "children": [ + 121370 + ], + "area": 1383029.4009480001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 121370, + "strid": "94b07978-a7a7-41d0-a6eb-844d9a61976f", + "image_id": 205225, + "image_name": "14469.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2707.063, + 1291.807, + 1107.261, + 67.72700000000009 + ], + "priority": 15, + "parents": [ + 121371 + ], + "children": [], + "area": 3497002.932841, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. After partialling out the ettects ot gender and age, Accumbens Ratio shows a\nsignificant relationship with average drinks per drinking day (ADDD) (F = 5.367, p = .001)." + }, + { + "id": 121368, + "strid": "1810dc98-632c-43f8-98e3-b33f2e05e39b", + "image_id": 205225, + "image_name": "14469.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3174.853, + 1370.56, + 244.1329999999998, + 50.402000000000044 + ], + "priority": 16, + "parents": [ + 121372 + ], + "children": [ + 121369 + ], + "area": 4351326.52768, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion" + }, + { + "id": 121369, + "strid": "5ffaeee1-c81f-4537-a686-6f87e7d2487b", + "image_id": 205225, + "image_name": "14469.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2694.463, + 1452.462, + 1211.214, + 510.31600000000003 + ], + "priority": 17, + "parents": [ + 121368 + ], + "children": [], + "area": 3913605.1179060005, + "iscrowd": 0, + "segmentation": [], + "text": "The key finding was that larger accumbens volume was\ncorrelated with increased drinking behavior. If adolescent\nneurodevelopment is biased toward subcortical (limbic) region\nrather than cortical (executive functioning) regions, clinical work\n\n \n\npurely cognitive model. Limitations include decreased\ngeneralizability (due to juvenile justice sample), and relying solely\non self-report to assess drinking behavior. Future studies should\nevaluate and compare adolescents at each year in development\n\nrather than combining a large age range." + }, + { + "id": 121366, + "strid": "95bc34f5-64a4-4d9f-9425-fe21f8b5d822", + "image_id": 205225, + "image_name": "14469.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3103.976, + 2554.998, + 418.96399999999994, + 53.552000000000135 + ], + "priority": 18, + "parents": [ + 121372 + ], + "children": [ + 121367 + ], + "area": 7930652.472048, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements" + }, + { + "id": 121367, + "strid": "c1eb44cb-cbc4-4a47-a389-f108971a9ece", + "image_id": 205225, + "image_name": "14469.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2713.363, + 2624.3, + 1208.0639999999999, + 154.35500000000002 + ], + "priority": 19, + "parents": [ + 121366 + ], + "children": [], + "area": 7120678.5209, + "iscrowd": 0, + "segmentation": [], + "text": "This research was supported by a NIAAA grant (RO1 AA017390, PI: A. Bryan) and the\nRSA Student Merit Award.\n\n*Presented at the 35'\" Annual Research Society on Alcoholism (RSA) Meeting in San\nFrancisco, California." + }, + { + "id": 121364, + "strid": "9db5e08e-2d6c-4f2c-8252-25f11504f644", + "image_id": 205225, + "image_name": "14469.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3182.728, + 1973.804, + 248.85800000000017, + 40.95100000000002 + ], + "priority": 20, + "parents": [ + 121372 + ], + "children": [ + 121365 + ], + "area": 6282081.257312001, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 121365, + "strid": "5b723008-24a5-4e66-8886-b19cf4afb2c3", + "image_id": 205225, + "image_name": "14469.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2713.363, + 2038.381, + 1170.263, + 483.54099999999994 + ], + "priority": 21, + "parents": [ + 121364 + ], + "children": [], + "area": 5530867.585303, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 3534, + "strid": "125e9d42-09e4-4818-a4e8-afc0b8ea8748", + "image_id": 200644, + "image_name": "10443.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 534.52, + 79.09, + 147.5, + 93.87 + ], + "priority": -1, + "parents": [], + "children": [ + 3533, + 3526, + 3525, + 3529, + 3523, + 3522, + 3530, + 3528, + 3532, + 3531, + 3527, + 3521 + ], + "area": 42275.1868, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 3523, + "strid": "b40b33a5-f0f0-4e03-b103-13e8df0f8a23", + "image_id": 200644, + "image_name": "10443.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 738.44, + 73.59, + 1854.703, + 132.479 + ], + "priority": 1, + "parents": [ + 3534 + ], + "children": [], + "area": 54341.799600000006, + "iscrowd": 0, + "segmentation": [], + "text": "Author Reagent Table: a proposal" + }, + { + "id": 3522, + "strid": "f061c3a1-3a92-44ed-b15b-791137884175", + "image_id": 200644, + "image_name": "10443.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 552.46, + 221.355, + 2259.783, + 157.956 + ], + "priority": 2, + "parents": [ + 3534 + ], + "children": [], + "area": 122289.7833, + "iscrowd": 0, + "segmentation": [], + "text": "Madeline Crosby, Norbert Perrimon, and the FlyBase Consortium*\nDepartment of Molecular and Cellular Biology, Harvard University" + }, + { + "id": 3532, + "strid": "e8664b80-ed53-4541-b991-ee1f02371987", + "image_id": 200644, + "image_name": "10443.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 33.619, + 433.47, + 2243.493, + 780.7270000000001 + ], + "priority": 3, + "parents": [ + 3534 + ], + "children": [], + "area": 14572.827930000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 3533, + "strid": "dbe3b67c-317b-4250-88cb-7b044be8f69a", + "image_id": 200644, + "image_name": "10443.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 38.005, + 1229.549, + 1394.782, + 557.0349999999999 + ], + "priority": 4, + "parents": [ + 3534 + ], + "children": [], + "area": 46729.009745, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 3521, + "strid": "f28ec0f8-dc8a-4310-97d4-d5b3225fc30e", + "image_id": 200644, + "image_name": "10443.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2118.215, + 758.584, + 253.1550000000002, + 50.50300000000004 + ], + "priority": 5, + "parents": [ + 3534 + ], + "children": [ + 3524 + ], + "area": 1606844.00756, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 3524, + "strid": "afe675b2-aca8-44c8-9da7-f2d64ef45e75", + "image_id": 200644, + "image_name": "10443.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1530.765, + 865.915, + 1429.2429999999997, + 856.017 + ], + "priority": 6, + "parents": [ + 3521 + ], + "children": [], + "area": 1325512.374975, + "iscrowd": 0, + "segmentation": [], + "text": "In consultation with other model organism databases, FlyBase has formulated a prototype \"author\nreagent table\" (ART). Our goal is to facilitate handling of reagent source and identifier information at\nmultiple steps, benefiting researchers, journals, and biological databases. The proposed ART is in the\nformat of a spreadsheet with standardized columns and invariant row labels. It is designed to be used\nregularly during the course of a research project, recording reagents as they are received and/or used.\nLab-wide use of such a common reagent form would facilitate tracking of reagents within the lab. At the\npoint of submission of a manuscript, with a completed ART in hand, provision of reagent data would be\nvery straightforward, particularly to journals using formatted submission systems such as STAR Methods\n(Marcus, E. et al., 2016; PMID:27565332). Use of reagent identifiers is one of the key requirements of\nthe system, encouraging the use of database and stock center identifiers, RRIDs (Bandrowski, A. et al.,\n2016; PMID:26589523), and catalog numbers for commercial providers. Wider use of identifiers and\nrecognized symbols would increase the transparency and reproducibility of biological research, while\nfacilitating curation into research databases. For genetic experiments, unambiguous identification of the\ngenes studied could be an additional component of the ART. A secondary goal of this proposed system is\nto encourage journals to make such data available as downloadable TSVs, spreadsheets or similar\nformats. The author reagent table could also be incorporated into the evolving use of preprint\nrepositories: an ART could simply be appended to the preprint manuscript. Feedback on this proposal\nfrom the larger biocuration community would be most welcome. Addendum: Genetics has now adopted\nthe author reagent table; see their “Preparing Manuscripts for Submission” page.\n\nThe template and example can be downloaded from flybase.org/journal/reagent_form." + }, + { + "id": 3525, + "strid": "1445b770-b764-4a19-a2bf-656d6868e0aa", + "image_id": 200644, + "image_name": "10443.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 27.64, + 1872.245, + 496.79600000000005, + 741.3719999999998 + ], + "priority": 7, + "parents": [ + 3534 + ], + "children": [], + "area": 51748.8518, + "iscrowd": 0, + "segmentation": [], + "text": "Designed to facilitate\nautomated parsing:\n\nColumn order and titles must\nremain unchanged.\n\nRows duplicated as needed (one\nrow for each reagent).\n\nRow titles must remain unchanged;\norder can be changed; unused\ncategories can be removed.\n\nColors entirely optional and can be\n(ol ar-Tay-i-1e" + }, + { + "id": 3531, + "strid": "f928ba36-e8c3-4872-8e3d-947c0cbd407e", + "image_id": 200644, + "image_name": "10443.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 548.986, + 1819.48, + 2429.903, + 875.0279999999998 + ], + "priority": 8, + "parents": [ + 3534 + ], + "children": [], + "area": 998869.0472799999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 3526, + "strid": "20beae55-64cf-412c-af2c-f25ac419f3e6", + "image_id": 200644, + "image_name": "10443.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 42.926, + 2779.215, + 468.771, + 369.4119999999998 + ], + "priority": 9, + "parents": [ + 3534 + ], + "children": [], + "area": 119300.58309000001, + "iscrowd": 0, + "segmentation": [], + "text": "Genetics and G3 are encouraging\nuse of the Reagent Table.\n\nThey are also soliciting feedback\n\nfrom authors.\n\nAdditional journals are being\ncontacted." + }, + { + "id": 3527, + "strid": "5091ce3c-f573-4d30-9977-a86f12e4eaff", + "image_id": 200644, + "image_name": "10443.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 562.651, + 2878.574, + 1006.3290000000001, + 789.7779999999998 + ], + "priority": 10, + "parents": [ + 3534 + ], + "children": [], + "area": 1619632.5396739999, + "iscrowd": 0, + "segmentation": [], + "text": "Reagent Table @\n\nWider use of identifiers and recognized symbols increases the transparency and\nreproducibility of biological research, while aiding curation into research databases.\nAuthors are encouraged to download the spreadsheet here (Excel file), which is designed\nto be used regularly during the course of a research project, recording reagents as they\nare received and/or used.\n\nThe spreadsheet format is convenient and flexible for the researcher and provides\ncommonly used download options for readers of publications. Lab-wide use of a\ncommon reagent form would facilitate tracking of reagents within the lab and provides\ninformation in a structured format that allows bulk downloads and greatly facilitates\ncuration into research databases. In addition to reagents, unambiguous identification of\nspecific genes studied is particularly helpful for genetic and genome databases, as well\nas for the larger research community.\n\nAuthors should upload the spreadsheet as a supplemental file and refer to it at least\nonce in their manuscript as \"Reagent Table\". No numbering is required. Please refer to\nthese instructions and this example file (Excel) when creating your Reagent Table using\nthis Excel file. This template is a new resource from FlyBase, with input from other model\norganism databases, and will be of use to the wider research community. We welcome\nyour feedback: genetics-gsa@thegsajournals.org." + }, + { + "id": 3530, + "strid": "38889b02-8897-465f-add0-4f87559bd663", + "image_id": 200644, + "image_name": "10443.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 62.655, + 3248.912, + 910.029, + 681.6010000000001 + ], + "priority": 11, + "parents": [ + 3534 + ], + "children": [], + "area": 203560.58135999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 3529, + "strid": "cbe686d0-746c-414a-9499-8a1501ff0b07", + "image_id": 200644, + "image_name": "10443.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1611.104, + 2981.503, + 1318.3999999999999, + 256.8710000000001 + ], + "priority": 12, + "parents": [ + 3534 + ], + "children": [], + "area": 4803511.4093120005, + "iscrowd": 0, + "segmentation": [], + "text": "Multiple outstanding issues, for example:\nShould there be a dedicated column for RRIDs? (Would that discourage use of other identifiers?)\nIdeally, the use of standard identifiers would facilitate rigorous searches of the literature. This\n\nproposal does not address that issue, since a reagent table as part of supplementary information\nwould not be visible to most text-mining." + }, + { + "id": 3528, + "strid": "bc64c9e5-0036-4067-bf96-8f7283ca92af", + "image_id": 200644, + "image_name": "10443.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1614.199, + 3283.25, + 1341.612, + 185.69000000000005 + ], + "priority": 13, + "parents": [ + 3534 + ], + "children": [], + "area": 5299818.86675, + "iscrowd": 0, + "segmentation": [], + "text": "We welcome feedback on this proposal, from researchers within and outside the model organism\ncommunities, from biocurators, and from any other interested parties.\n\nAll feedback is helpful — whether detailed and specific, or more general. We are especially\ninterested in additional data types that should be added." + }, + { + "id": 105260, + "strid": "e1212fc5-68c2-4fba-b3a9-6ac819c31456", + "image_id": 204570, + "image_name": "12343.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 4.05, + 12.2, + 100.56, + 57.47 + ], + "priority": -1, + "parents": [], + "children": [ + 105255, + 105252, + 105256, + 105253, + 105254, + 105257, + 105258, + 105251 + ], + "area": 49.41, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 105251, + "strid": "66e7e3c7-448c-47be-afea-a8f3b7251092", + "image_id": 204570, + "image_name": "12343.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 111.949, + 89.438, + 603.471, + 69.474 + ], + "priority": 1, + "parents": [ + 105260 + ], + "children": [], + "area": 10012.494662000001, + "iscrowd": 0, + "segmentation": [], + "text": "Bioinformatics Training and Education:\ntowards a sustainable global network" + }, + { + "id": 105252, + "strid": "2580b72a-f8d8-4418-8db0-059487b3b4b7", + "image_id": 204570, + "image_name": "12343.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 81.242, + 224.353, + 428.198, + 177.185 + ], + "priority": 2, + "parents": [ + 105260 + ], + "children": [], + "area": 18226.886426, + "iscrowd": 0, + "segmentation": [], + "text": "The Global Organisation for Bioinformatics Learning,\nEducation & Training (GOBLET) evolved from the BTN - the\nBioinformatics Training Network?. Arising from a recognised\nneed to coordinate a spectrum of world-wide training\nactivities in bioinformatics, biocuration, biocomputing and\ncomputational biology, its members aim to: share, not\nduplicate, effort; share, not duplicate, cost; to work together,\nin a mutually respectful way, towards common solutions and\na sustainable future. Join us at www.mygoblet.org" + }, + { + "id": 105255, + "strid": "94dedf33-51b2-4def-91bc-56a4a11f78bb", + "image_id": 204570, + "image_name": "12343.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 554.109, + 213.472, + 189.60500000000002, + 202.20699999999997 + ], + "priority": 3, + "parents": [ + 105260 + ], + "children": [], + "area": 118286.75644800001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 105256, + "strid": "f48acd14-5f5d-417a-b800-fc29755fec0f", + "image_id": 204570, + "image_name": "12343.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 68.74, + 442.236, + 567.746, + 210.37199999999996 + ], + "priority": 4, + "parents": [ + 105260 + ], + "children": [], + "area": 30399.302639999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 105257, + "strid": "93bf5ba0-74fb-417f-9c2f-387efad8dbd9", + "image_id": 204570, + "image_name": "12343.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 638.01, + 430.741, + 148.543, + 87.34299999999996 + ], + "priority": 5, + "parents": [ + 105260 + ], + "children": [ + 105259 + ], + "area": 274817.06541, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 105259, + "strid": "dc42f359-9285-4099-8e77-c9af8e38ada0", + "image_id": 204570, + "image_name": "12343.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 677.409, + 518.644, + 65.25800000000004, + 12.745000000000005 + ], + "priority": 6, + "parents": [ + 105257 + ], + "children": [], + "area": 351334.113396, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 105258, + "strid": "7ab6e9c5-bb08-4f7c-8371-885461b63a7b", + "image_id": 204570, + "image_name": "12343.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 654.656, + 535.901, + 110.57100000000003, + 86.41499999999996 + ], + "priority": 7, + "parents": [ + 105260 + ], + "children": [], + "area": 350830.80505599995, + "iscrowd": 0, + "segmentation": [], + "text": "a global umbrella\norganisation for\nsocieties,\nnetworks &\ninstitutions" + }, + { + "id": 105253, + "strid": "fa546c11-e0ef-4bc5-ad2d-39052a367748", + "image_id": 204570, + "image_name": "12343.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 75.487, + 687.59, + 668.117, + 99.29899999999998 + ], + "priority": 8, + "parents": [ + 105260 + ], + "children": [], + "area": 51904.10633, + "iscrowd": 0, + "segmentation": [], + "text": "Steered by an Executive Board (elected by the membership) and five Committees (Education &\nTraining, Outreach & PR, Technology, Standarisation and Fund-raising), GOBLET is about action -\nworking together towards pragmatic solutions to common problems?*, Building on the work of\nthe BTN, GOBLET has launched a Training Portal, offering a registry of trainers, organisers, events,\nand materials and documents, providing a sharing platform for trainers and trainees alike." + }, + { + "id": 105254, + "strid": "253a4014-e212-48a4-a907-d93699deff84", + "image_id": 204570, + "image_name": "12343.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 82.017, + 828.293, + 664.4009999999998, + 75.11900000000003 + ], + "priority": 9, + "parents": [ + 105260 + ], + "children": [], + "area": 67934.10698099999, + "iscrowd": 0, + "segmentation": [], + "text": "GOBLET worked with ISCB to establish a poster track for education at ISMB conferences. It is also\ndeveloping standards for disseminating life science events‘, preparing best practice guidelines for\nbioinformatics training’, exploring ways to bring recognition and accreditation to training, and is\nliaising with ELIXIR to interface with the European research infrastructure for biological data." + }, + { + "id": 148680, + "strid": "efaadedb-df03-4e1f-9fed-8ef6c5eb63bf", + "image_id": 206275, + "image_name": "20097.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 12.26, + 13.79, + 55.440000000000005, + 112.86000000000001 + ], + "priority": -1, + "parents": [], + "children": [ + 148669, + 148670, + 148667, + 148668, + 148671, + 148673, + 148672 + ], + "area": 169.06539999999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 148667, + "strid": "c5e4269b-d85c-4710-925f-195415e1754c", + "image_id": 206275, + "image_name": "20097.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 86.098, + 40.777, + 1260.393, + 127.949 + ], + "priority": 1, + "parents": [ + 148680 + ], + "children": [], + "area": 3510.818146, + "iscrowd": 0, + "segmentation": [], + "text": "Content analysis of institutional policies on open science\n\nJournée des doctorants ELICO\n\nAlejandra Manco LG YTD" + }, + { + "id": 148668, + "strid": "deae9feb-3a55-4327-8620-1095b0a1a308", + "image_id": 206275, + "image_name": "20097.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 899.85, + 107.453, + 419.94999999999993, + 65.27599999999998 + ], + "priority": 2, + "parents": [ + 148680 + ], + "children": [], + "area": 96691.58205000001, + "iscrowd": 0, + "segmentation": [], + "text": "Journée des doctorants ELICO\n28-01-2022" + }, + { + "id": 148669, + "strid": "78799edb-cd12-48a5-9de9-862ec7c29938", + "image_id": 206275, + "image_name": "20097.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 148.308, + 262.792, + 212.86400000000003, + 33.079999999999984 + ], + "priority": 3, + "parents": [ + 148680 + ], + "children": [ + 148675, + 148674 + ], + "area": 38974.155935999996, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 148674, + "strid": "0eb29882-7980-4d3a-91c5-b14528447702", + "image_id": 206275, + "image_name": "20097.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 32.35, + 345.699, + 468.104, + 220.66799999999995 + ], + "priority": 4, + "parents": [ + 148669 + ], + "children": [], + "area": 11183.362650000001, + "iscrowd": 0, + "segmentation": [], + "text": "Open science is gaining traction around the\n\nworld with open science policies being enacted\n\nat different levels.\n\nOpen Science policy implementation is behind\n(Morais et al., 2021). There are unintended effects of\npolicy implementation are the gaps between OS policy\nand research practice possibly due to the lack of\nweight of scientists on political decisions that impact\nthem (Lilja, 2021)." + }, + { + "id": 148675, + "strid": "180e4f4f-08d6-4e2e-a9e3-af4fd0648405", + "image_id": 206275, + "image_name": "20097.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 33.536, + 567.207, + 254.151, + 97.26300000000003 + ], + "priority": 5, + "parents": [ + 148669 + ], + "children": [], + "area": 19021.853952, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 148670, + "strid": "b3975ba7-0775-49e7-bf72-79aae07cbe53", + "image_id": 206275, + "image_name": "20097.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 131.75, + 713.051, + 241.85199999999998, + 39.952 + ], + "priority": 6, + "parents": [ + 148680 + ], + "children": [ + 148676 + ], + "area": 93944.46925000001, + "iscrowd": 0, + "segmentation": [], + "text": "Methodology" + }, + { + "id": 148676, + "strid": "533a0774-a2bb-4e09-bb0f-d70ed430b63e", + "image_id": 206275, + "image_name": "20097.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 26.45, + 834.846, + 406.882, + 235.47399999999993 + ], + "priority": 7, + "parents": [ + 148670 + ], + "children": [], + "area": 22081.6767, + "iscrowd": 0, + "segmentation": [], + "text": "Panel Countries: France and the UK\n\nCorpus: 15 documents\n\nDates: 2014-2021\n\nMethod: content analysis (Krippendorff, 2004)\n\nInductive analysis using Nvivo software" + }, + { + "id": 148671, + "strid": "657d8573-e443-4381-be01-41e93b2fa3ef", + "image_id": 206275, + "image_name": "20097.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 744.459, + 264.793, + 140.212, + 30.08499999999998 + ], + "priority": 8, + "parents": [ + 148680 + ], + "children": [ + 148677 + ], + "area": 197127.531987, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 148677, + "strid": "bb9afc9c-75cd-4e4e-84b9-35b8ed1340f5", + "image_id": 206275, + "image_name": "20097.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 519.14, + 357.461, + 626.32, + 774.886 + ], + "priority": 9, + "parents": [ + 148671 + ], + "children": [], + "area": 185572.30354, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 148672, + "strid": "da970e68-8c52-4187-8699-9f64346d119a", + "image_id": 206275, + "image_name": "20097.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1274.4, + 263.105, + 226.33500000000004, + 32.398000000000025 + ], + "priority": 10, + "parents": [ + 148680 + ], + "children": [ + 148679 + ], + "area": 335301.01200000005, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 148679, + "strid": "b2661599-7926-4700-8e08-bdfabf2007d2", + "image_id": 206275, + "image_name": "20097.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1151.873, + 350.783, + 498.9290000000001, + 245.60699999999997 + ], + "priority": 11, + "parents": [ + 148672 + ], + "children": [], + "area": 404057.466559, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 148673, + "strid": "4df0a9de-0e74-46da-a295-49be3d02fe01", + "image_id": 206275, + "image_name": "20097.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1273.771, + 715.801, + 211.60300000000007, + 32.76400000000001 + ], + "priority": 12, + "parents": [ + 148680 + ], + "children": [ + 148678 + ], + "area": 911766.555571, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 148678, + "strid": "0b4152d3-1028-4e28-bcaf-efa2d7c85ddb", + "image_id": 206275, + "image_name": "20097.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1158.493, + 830.219, + 496.27099999999996, + 272.91200000000003 + ], + "priority": 13, + "parents": [ + 148673 + ], + "children": [], + "area": 961802.899967, + "iscrowd": 0, + "segmentation": [], + "text": "Krippendorff, K. (2004). Content analysis: an introductio!\nto its methodology. Thousand Oaks: Sage.\n\nLilja, E. (2021). Threat of policy alienation:\nExploring the implementation of Open Science\npolicy in research practice. Science and Public\nPolicy, 47(6), 803-817.\nhttps://doi.org/10.1093/scipol/scaao44.\n\nMorais, R., Saenen, B., Garbuglia, F.,\n\n& Gaillard, V. (2021). From principles to practices:\nOpen Science at Europe’s universities: 2020-2021\nEUA Open Science Survey results" + }, + { + "id": 129936, + "strid": "0966b2d5-c8e4-4b53-b8fb-ae9b2054e417", + "image_id": 205549, + "image_name": "15310.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 150.29, + 210.72, + 217.93000000000004, + 198.11999999999998 + ], + "priority": -1, + "parents": [], + "children": [ + 129925, + 129932, + 129924, + 129927, + 129923, + 129922 + ], + "area": 31669.108799999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 129922, + "strid": "bc28766c-ef34-4d54-aa3a-6849b0d4b68d", + "image_id": 205549, + "image_name": "15310.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 466.159, + 179.757, + 1395.8779999999997, + 217.78199999999998 + ], + "priority": 1, + "parents": [ + 129936 + ], + "children": [], + "area": 83795.343363, + "iscrowd": 0, + "segmentation": [], + "text": "MetagenApp\nThe City in the Palm of your Hand" + }, + { + "id": 129923, + "strid": "4cf58740-af0d-4683-939c-ef407225f039", + "image_id": 205549, + "image_name": "15310.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 432.974, + 434.873, + 1474.695, + 182.522 + ], + "priority": 2, + "parents": [ + 129936 + ], + "children": [], + "area": 188288.702302, + "iscrowd": 0, + "segmentation": [], + "text": "Josef W. Moser?, Alexandra B. Graf”\n\n1University of Applied Sciences FH Campus Wien, Department Bioengineering, Vienna, Austria\n* Corresponding Author" + }, + { + "id": 129924, + "strid": "e3c7363c-ab6f-45ab-a48e-983657786266", + "image_id": 205549, + "image_name": "15310.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 121.562, + 779.844, + 294.767, + 55.379999999999995 + ], + "priority": 3, + "parents": [ + 129936 + ], + "children": [ + 129926 + ], + "area": 94799.396328, + "iscrowd": 0, + "segmentation": [], + "text": "Background" + }, + { + "id": 129926, + "strid": "740a07d1-d82b-4a1a-97b7-399d10aa266f", + "image_id": 205549, + "image_name": "15310.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 127.046, + 884.356, + 1417.833, + 1003.3889999999999 + ], + "priority": 4, + "parents": [ + 129924 + ], + "children": [], + "area": 112353.892376, + "iscrowd": 0, + "segmentation": [], + "text": "Metagenomics has gained an impressive momentum, with applications in fields ranging\nfrom medicine to criminology. For targeted metagenomics, especially 16S there are\nalready standardized pipelines and programs that summarize the majority of the needed\nfunctionality (1). In whole genome metagenomics no clear analysis framework has yet\nemerged (2). Furthermore, most of the available tools are Linux based and require a\nmedium to high expertise in bioinformatics, and therefore represent a barrier in\nusability.\n\nSeveral studies on urban and indoor environments have demonstrated that the found\nmicrobiome is largely deposited there by the immediate surrounding (3). The majority\nof the found organisms was deposited on surfaces by humans as part of their normal\nmicrobiome that is emitted into the environment in a could of 3,8-92 Mio cells/hour (4).\nBut how much of the microbial content is transferred back to our skin when we touch\nsurfaces. To investigate we performed a whole genome metagenomics study on 54\nindividuals before and after a trip through the city by public transport. Whole genome\nsequencing was performed on extracted DNA from palm swabs with Illumina paired-end\nsequencing. Analysis was performed using our application.\n\nWe present a open source dockerized metagenome analysis application making use of\nBioContainers where available. The application can be run in a web environment as well\nas locally in a Windows, Apple or Linux environment. It handles long and short read data\nand has been tested on PacBio and Illumina whole metagenome sequence reads." + }, + { + "id": 129927, + "strid": "26136a29-5a5e-4cef-8067-4eb956a24072", + "image_id": 205549, + "image_name": "15310.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 103.544, + 1967.915, + 243.52300000000002, + 59.33999999999992 + ], + "priority": 5, + "parents": [ + 129936 + ], + "children": [ + 129928 + ], + "area": 203765.79076, + "iscrowd": 0, + "segmentation": [], + "text": "Workflow" + }, + { + "id": 129928, + "strid": "b62a8a0b-bc61-4905-8c1d-75428022188b", + "image_id": 205549, + "image_name": "15310.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 178.146, + 2116.87, + 1321.322, + 1822.777 + ], + "priority": 6, + "parents": [ + 129927 + ], + "children": [ + 129929 + ], + "area": 377111.92301999993, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 129929, + "strid": "f8861f72-bc4f-46d8-9f4b-e66d5d04006c", + "image_id": 205549, + "image_name": "15310.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 301.079, + 3979.895, + 1008.7160000000001, + 46.20899999999983 + ], + "priority": 7, + "parents": [ + 129928 + ], + "children": [], + "area": 1198262.806705, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 1 Workflow schemata: Schematic workflow of metagenomics analysis." + }, + { + "id": 129925, + "strid": "564cae19-c337-4f09-b911-9fb900aac5cb", + "image_id": 205549, + "image_name": "15310.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1729.171, + 774.178, + 397.0899999999999, + 57.660999999999945 + ], + "priority": 8, + "parents": [ + 129936 + ], + "children": [ + 129930 + ], + "area": 1338686.146438, + "iscrowd": 0, + "segmentation": [], + "text": "Implementation" + }, + { + "id": 129930, + "strid": "bbf7568d-d90f-4457-99b4-062dc74ed760", + "image_id": 205549, + "image_name": "15310.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1752.458, + 888.352, + 1388.8449999999998, + 1805.0460000000003 + ], + "priority": 9, + "parents": [ + 129925 + ], + "children": [ + 129931 + ], + "area": 1556799.569216, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 129931, + "strid": "661547fe-a985-4fff-bd40-4a13ae765f21", + "image_id": 205549, + "image_name": "15310.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1827.67, + 2709.519, + 1240.815, + 120.88200000000006 + ], + "priority": 10, + "parents": [ + 129930 + ], + "children": [], + "area": 4952106.590729999, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 2 Implementation of application: The workflow was implemented in a set of docker /\nBiocontainer, run by a Python script. The analysis results, together with available metadata,\npopulate a back end PostgreSQL database that is accessible through Django and uWSGI." + }, + { + "id": 129932, + "strid": "02673740-3f98-4bfd-8cc0-ac14c9c874b1", + "image_id": 205549, + "image_name": "15310.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1727.243, + 2928.792, + 334.13599999999997, + 55.78800000000001 + ], + "priority": 11, + "parents": [ + 129936 + ], + "children": [ + 129934, + 129933 + ], + "area": 5058735.480455999, + "iscrowd": 0, + "segmentation": [], + "text": "Study Results" + }, + { + "id": 129933, + "strid": "1a4fca99-4454-4758-9809-651885ad0680", + "image_id": 205549, + "image_name": "15310.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1723.744, + 3051.182, + 1436.5070000000003, + 376.422 + ], + "priority": 12, + "parents": [ + 129932 + ], + "children": [], + "area": 5259456.665407999, + "iscrowd": 0, + "segmentation": [], + "text": "Results indicate a shift towards higher microbiome diversity in the after samples, but also\nshow an enrichment of certain non-skin-related species in the before samples (after hand\nwashing), which decreases in abundance over time. Although variability between\nindividuals was high, several significant species in the before samples correlated with\nwarm water, most likely representing a residue from hand washing. Categories enriched\nin the after samples were mainly food associated microbes. In terms of metabolic\ncategory, The highest abundant category in both sets was, not surprisingly, species of the\nskin microbiome." + }, + { + "id": 129934, + "strid": "530d8dc7-4f29-4e7e-ad00-d14210a31949", + "image_id": 205549, + "image_name": "15310.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1707.282, + 3486.619, + 1391.144, + 648.2999999999997 + ], + "priority": 13, + "parents": [ + 129932 + ], + "children": [ + 129935 + ], + "area": 5952641.859558, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 129935, + "strid": "4f92dbf1-c912-4b2b-9b2e-c5c8a53d83bf", + "image_id": 205549, + "image_name": "15310.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1826.321, + 4165.251, + 1182.495, + 81.27999999999975 + ], + "priority": 14, + "parents": [ + 129934 + ], + "children": [], + "area": 7607085.371571, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 3 Abundance differences (log2) of metabolic functions encoded in the genome of\nspecies found in the before and after samples." + }, + { + "id": 10251, + "strid": "bfffcc27-70f6-437b-9fa8-a7daaf5ea668", + "image_id": 200912, + "image_name": "11299.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 186.37, + 107.5, + 171.14, + 179.29000000000002 + ], + "priority": -1, + "parents": [], + "children": [ + 10247, + 10259, + 10256, + 10252, + 10262, + 10245, + 10255, + 10250, + 10246, + 10261 + ], + "area": 20034.775, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 10246, + "strid": "2fcd1e9b-61e0-4065-9ab3-393724db3ffc", + "image_id": 200912, + "image_name": "11299.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 460.117, + 262.538, + 2626.269, + 180.55600000000004 + ], + "priority": 1, + "parents": [ + 10251 + ], + "children": [], + "area": 120798.19694600001, + "iscrowd": 0, + "segmentation": [], + "text": "GOBLET Standards Committee:" + }, + { + "id": 10245, + "strid": "5662f8a9-7214-45c6-ad54-6da2376c0bce", + "image_id": 200912, + "image_name": "11299.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 455.894, + 478.478, + 2789.2929999999997, + 353.632 + ], + "priority": 2, + "parents": [ + 10251 + ], + "children": [], + "area": 218135.249332, + "iscrowd": 0, + "segmentation": [], + "text": "our activities and forward vision\n\nSonika Tyagi, Maria Victoria Schneider?, Sarah L. Morgan’, Michael Charleston?>, Patricia M. Palagi®,\nJudit Kumuthini’, Gabriella Rustici® and Teresa K. Attwood?\n\ntMonash Bioinformatics Platform, Monash University, AU; 7AGRF, AU; 7EMBL-ABR, AU; 7EMBL-EBI, UK; °University of Tasmania,\nAU; °SIB Swiss Institute of Bioinformatics; 7\"CPGR, ZA; ®University of Cambridge, UK; °University of Manchester, UK" + }, + { + "id": 10247, + "strid": "fc5259c3-da46-4895-b97c-5d5908ed63c7", + "image_id": 200912, + "image_name": "11299.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 157.248, + 876.652, + 252.55900000000003, + 53.652000000000044 + ], + "priority": 3, + "parents": [ + 10251 + ], + "children": [ + 10249 + ], + "area": 137851.773696, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 10249, + "strid": "4f7b7c2b-c579-4393-b144-5a477bce7a4f", + "image_id": 200912, + "image_name": "11299.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 147.679, + 960.636, + 3284.097, + 423.299 + ], + "priority": 4, + "parents": [ + 10247 + ], + "children": [], + "area": 141865.763844, + "iscrowd": 0, + "segmentation": [], + "text": "Recognising the importance of internationally-recognised standards in data-driven science, GOBLET’s?\nStandards Committee is contributing to the open science data life-cycle by helping both to develop standards\nfor annotating training materials and events?, and to raise awareness of life-science data standards (including\nFAIR principles) through training provision. Here, we introduce some of the Committee’s work and review\n\npreliminary results of our standards-awareness survey." + }, + { + "id": 10252, + "strid": "18cb211a-5580-43d4-b640-2bee6fe02cc1", + "image_id": 200912, + "image_name": "11299.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 129.185, + 1458.438, + 853.922, + 58.46499999999992 + ], + "priority": 5, + "parents": [ + 10251 + ], + "children": [ + 10260 + ], + "area": 188408.31303000002, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 10260, + "strid": "7682daad-1da5-4664-8875-d8b755fd23d7", + "image_id": 200912, + "image_name": "11299.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 119.399, + 1556.058, + 1509.2060000000001, + 303.405 + ], + "priority": 6, + "parents": [ + 10252 + ], + "children": [], + "area": 185791.769142, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 10256, + "strid": "fe35f5f8-1d30-42e3-a03d-bf2b15e3e6eb", + "image_id": 200912, + "image_name": "11299.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1841.415, + 1459.124, + 389.14400000000023, + 55.827 + ], + "priority": 7, + "parents": [ + 10251 + ], + "children": [ + 10254 + ], + "area": 2686852.82046, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 10254, + "strid": "83fbf45d-2eb3-4cbb-bed1-9b2f78c0b681", + "image_id": 200912, + "image_name": "11299.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1832.905, + 1548.031, + 1626.0380000000002, + 777.1239999999998 + ], + "priority": 8, + "parents": [ + 10256 + ], + "children": [], + "area": 2837393.760055, + "iscrowd": 0, + "segmentation": [], + "text": "Standards are fundamental to the data life-cycle.\nNumerous standards exist in the life sciences (from\ndata collection to annotation, preservation and\npublication), all playing vital roles for data sharing and\nreuse. We are currently surveying awareness of\nstandards and their adoption in the life sciences.\nHere, we present the initial results, highlighting an\nalarming lack of standards awareness, about their\nimportance, what they are and when to use them." + }, + { + "id": 10255, + "strid": "4c07defe-f451-4770-b910-75fa305025d5", + "image_id": 200912, + "image_name": "11299.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 112.53, + 1957.556, + 1591.171, + 809.5430000000001 + ], + "priority": 9, + "parents": [ + 10251 + ], + "children": [], + "area": 220283.77668, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 10259, + "strid": "d77c9d13-6711-4464-9de7-2b1ad67b0fd4", + "image_id": 200912, + "image_name": "11299.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1827.508, + 2415.176, + 617.4379999999999, + 67.21000000000004 + ], + "priority": 10, + "parents": [ + 10251 + ], + "children": [ + 10248, + 10258 + ], + "area": 4413753.4614079995, + "iscrowd": 0, + "segmentation": [], + "text": "Preliminary Findings" + }, + { + "id": 10248, + "strid": "8c20ab8e-f93c-4d33-8025-0b44d89f8acd", + "image_id": 200912, + "image_name": "11299.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1807.796, + 2508.83, + 1667.363, + 574.5639999999999 + ], + "priority": 11, + "parents": [ + 10259 + ], + "children": [], + "area": 4535452.83868, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 10258, + "strid": "7b771dc8-5472-457a-b505-d09277425814", + "image_id": 200912, + "image_name": "11299.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1814.007, + 3115.307, + 1607.0949999999998, + 311.05099999999993 + ], + "priority": 12, + "parents": [ + 10259 + ], + "children": [], + "area": 5651188.705149, + "iscrowd": 0, + "segmentation": [], + "text": "So far, we have received limited responses to the survey in\ngeneral, and to the topic of training material standards in\nparticular; nevertheless, the latter was listed amongst the\ntop priority standards to be developed (data not shown)." + }, + { + "id": 10261, + "strid": "099768f4-e7c9-4f61-bf9c-8f1c86d22a09", + "image_id": 200912, + "image_name": "11299.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 117.397, + 2850.228, + 1091.473, + 70.74299999999994 + ], + "priority": 13, + "parents": [ + 10251 + ], + "children": [ + 10253 + ], + "area": 334608.21651600004, + "iscrowd": 0, + "segmentation": [], + "text": "Future Activities, Moving Forward" + }, + { + "id": 10253, + "strid": "101a69b8-5b29-45dc-bc8c-b964a28feb29", + "image_id": 200912, + "image_name": "11299.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 105.617, + 2940.576, + 1599.428, + 800.8710000000001 + ], + "priority": 14, + "parents": [ + 10261 + ], + "children": [], + "area": 310574.815392, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 10250, + "strid": "1ba7a7bf-0759-478a-a3cc-86baf260bb77", + "image_id": 200912, + "image_name": "11299.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1844.974, + 3512.528, + 1594.6160000000002, + 936.7469999999998 + ], + "priority": 15, + "parents": [ + 10251 + ], + "children": [], + "area": 6480522.834271999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 10262, + "strid": "cfa16f52-6f45-45c1-bc54-a3b4240a4834", + "image_id": 200912, + "image_name": "11299.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 142.599, + 3796.809, + 322.392, + 46.94399999999996 + ], + "priority": 16, + "parents": [ + 10251 + ], + "children": [ + 10257 + ], + "area": 541421.166591, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 10257, + "strid": "60ae0540-803e-445f-b8cb-14919d15c241", + "image_id": 200912, + "image_name": "11299.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 122.041, + 3862.845, + 1588.292, + 595.4000000000001 + ], + "priority": 17, + "parents": [ + 10262 + ], + "children": [], + "area": 471425.466645, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 153374, + "strid": "c3777cce-e558-46c5-bffb-edcc76db793e", + "image_id": 206476, + "image_name": "21537.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 52.25, + 22.57, + 204.32999999999998, + 223.49 + ], + "priority": -1, + "parents": [], + "children": [ + 153349, + 153353, + 153350, + 153351, + 153352, + 153355, + 153354 + ], + "area": 1179.2825, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 153349, + "strid": "558354d5-5756-405d-ade1-687c270f9fc4", + "image_id": 206476, + "image_name": "21537.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 502.719, + 56.58, + 2393.723, + 206.62400000000002 + ], + "priority": 1, + "parents": [ + 153374 + ], + "children": [], + "area": 28443.84102, + "iscrowd": 0, + "segmentation": [], + "text": "FOODRUGS: AN EXPLORATORY MINING WEB\nAPPLICATION FOR FOOD - DRUG INTERACTIONS" + }, + { + "id": 153350, + "strid": "0771d24a-8c70-49fc-ad87-5f43ab1adf53", + "image_id": 206476, + "image_name": "21537.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 76.122, + 325.259, + 3001.291, + 345.717 + ], + "priority": 2, + "parents": [ + 153374 + ], + "children": [], + "area": 24759.365598, + "iscrowd": 0, + "segmentation": [], + "text": "Marco Garranzo', Teresa Laguna', David Pérez', Blanca Lacruz', Maria Isabel Espinosa?,\nAna Ramirez de Molina’, Enrique Carrillo-de-Santa-Pau |\n\n' Computational Biology Group, IMDEA Food Institute, Madrid, Spain CX] enrique.carrillo@im\nNutritional Genomics and Health Unit, GENYAL Platform, IMDEA Food Institute, Madrid, Spain W @esantapa" + }, + { + "id": 153351, + "strid": "ff97a2a2-5b01-4531-a54f-04cece3eb621", + "image_id": 206476, + "image_name": "21537.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1529.362, + 776.795, + 264.29999999999995, + 41.01200000000006 + ], + "priority": 3, + "parents": [ + 153374 + ], + "children": [ + 153356 + ], + "area": 1188000.75479, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 153356, + "strid": "2ad44b46-40b3-4571-92aa-bf7b99c00c41", + "image_id": 206476, + "image_name": "21537.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 89.738, + 872.356, + 3144.961, + 472.808 + ], + "priority": 4, + "parents": [ + 153351 + ], + "children": [], + "area": 78283.482728, + "iscrowd": 0, + "segmentation": [], + "text": "The consumption of supplement foods with an active role to prevent non-communicable diseases have increased during the last years raising concerns over\nthe potential interactions with drugs, particularly in patients undergoing chronic therapy. However, the current knowledge of them in clinical practice has been\nreported to be unsatisfactory. Therefore, It is required to develop computational tools to exploit the vast information available in dispersed databases about\nfood-drug interactions. We present FOODRUGS, a friendly-user webapp to access and explore putative food-drug interactions. Users can explore\ntranscriptomic relationships between food and drugs through a similarity bipartite network built with 585 food transcriptomic profiles from GEO and the CMAP\ndatabase for drug profiles. Food and drug nodes are connected by a positive or negative tau score representing the similarity (positive) or dissimilarity\n(negative) relationship, meaning for a putative similar or opposite mechanism of action. In addition, enrichment analysis to annotate drug compounds for a\n\nfood node can be performed. Lastly, more than 2.500 scientific documents from Pubmed, drugbank and drugs.com can be consulted after applying NLP\ntechniques to extract relevant food-drug interactions." + }, + { + "id": 153352, + "strid": "7c1b7197-726a-42ec-84b8-47c3f4d63af1", + "image_id": 206476, + "image_name": "21537.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1403.766, + 1425.197, + 549.222, + 44.903999999999996 + ], + "priority": 5, + "parents": [ + 153374 + ], + "children": [ + 153358 + ], + "area": 2000643.091902, + "iscrowd": 0, + "segmentation": [], + "text": "FOODRUGS DATABASE" + }, + { + "id": 153358, + "strid": "86fd5980-287d-4596-9dd8-a94a669640e3", + "image_id": 206476, + "image_name": "21537.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 186.47, + 1516.238, + 3041.094, + 773.6870000000001 + ], + "priority": 6, + "parents": [ + 153352 + ], + "children": [ + 153369 + ], + "area": 282732.89986, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 153369, + "strid": "0492e3d8-17ac-47e1-974a-e9483bd3da02", + "image_id": 206476, + "image_name": "21537.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 105.969, + 2311.783, + 3121.624, + 90.16800000000012 + ], + "priority": 7, + "parents": [ + 153358 + ], + "children": [], + "area": 244977.33272699997, + "iscrowd": 0, + "segmentation": [], + "text": "Cite: Carrillo de Santa Pau, Enrique, Garranzo, Marco, & Laguna Lobo, Teresa. (2022). FooDrugs database: A database with molecular and text information about food - drug interactions (2.0.0) [Data set]. Zenodo. https://doi.org/10.528 1/zenodo.6638470\n\nAccess FooDrugs database: http://imdeafoodcompubio.com/index.php/download/" + }, + { + "id": 153353, + "strid": "45b0bbf6-c098-4ed3-932c-efaf628fffb7", + "image_id": 206476, + "image_name": "21537.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1409.631, + 2436.052, + 539.1600000000001, + 41.715000000000146 + ], + "priority": 8, + "parents": [ + 153374 + ], + "children": [ + 153366, + 153359, + 153360, + 153368, + 153364, + 153367, + 153363, + 153362, + 153365, + 153361 + ], + "area": 3433934.4168120003, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 153362, + "strid": "523f9f8c-b7d0-4d05-a87a-455c80a83130", + "image_id": 206476, + "image_name": "21537.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 695.99, + 2515.628, + 2014.552, + 74.54899999999998 + ], + "priority": 9, + "parents": [ + 153353 + ], + "children": [], + "area": 1750851.9317200002, + "iscrowd": 0, + "segmentation": [], + "text": "Access: http://imdeafoodcompubio.com/index.php/foodrugs/" + }, + { + "id": 153364, + "strid": "d1e942e8-8adc-4853-9fc2-6df3e8ee8fef", + "image_id": 206476, + "image_name": "21537.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 225.259, + 2623.52, + 587.437, + 33.99800000000005 + ], + "priority": 10, + "parents": [ + 153353 + ], + "children": [], + "area": 590971.49168, + "iscrowd": 0, + "segmentation": [], + "text": "Welcome website and analysis access" + }, + { + "id": 153363, + "strid": "f9659330-37f4-4148-9270-d062ebde11fe", + "image_id": 206476, + "image_name": "21537.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 126.272, + 2618.704, + 951.6929999999999, + 637.712 + ], + "priority": 11, + "parents": [ + 153353 + ], + "children": [], + "area": 330668.991488, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 153361, + "strid": "4c8e21eb-3344-45ad-aca2-e2116cde0284", + "image_id": 206476, + "image_name": "21537.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1875.033, + 2683.87, + 753.4119999999998, + 36.99200000000019 + ], + "priority": 12, + "parents": [ + 153353 + ], + "children": [], + "area": 5032344.817709999, + "iscrowd": 0, + "segmentation": [], + "text": "Transcriptomic FooDrug exploratory analysis" + }, + { + "id": 153359, + "strid": "dc98d1cf-a2ba-4141-961d-564173a4cd53", + "image_id": 206476, + "image_name": "21537.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1316.183, + 2718.498, + 1041.833, + 661.4789999999998 + ], + "priority": 13, + "parents": [ + 153353 + ], + "children": [ + 153370 + ], + "area": 3578040.853134, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 153370, + "strid": "dfd6db44-6a0e-481f-adf2-e25d719cdf16", + "image_id": 206476, + "image_name": "21537.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2380.703, + 2783.119, + 845.2689999999998, + 506.7959999999998 + ], + "priority": 14, + "parents": [ + 153359 + ], + "children": [], + "area": 6625779.752657, + "iscrowd": 0, + "segmentation": [], + "text": "2a) Search box and filtering options: Researchers can interrogate for\nfood or drug terms for FDI or food-gene interactions and filtering by\nsample cell type or tau score cut-off\n\n2b) Food available experiments: A table with food transcriptomic\nexperiments is displayed showing GEO accession, food name, time\npoint, concentration, cell type for the experiment, and the node id in the\nnetwork.\n\n2c) Interaction network: Once an experiment is selected a network\nwith food-drug interactions is displayed. Central node is the food\nselected, peripheral nodes are the drugs and the edge is the tau score\nconsidering the cut-off selected in the search box.\n\n2d) Interaction table: Once an experiment is selected a table with all\nits drug interactions is displayed for the tau score cut-off selected.\n\n2e) Enrichment analysis: A binomial test is used to determine if the\nneighbours of a node are over or underrepresented for DrugBank,\nDrugs.com, CMAP, MeSH or KEGG phytochemicals annotations" + }, + { + "id": 153360, + "strid": "146bc4ea-bdd4-4ca9-b8a2-16b65d42e7fe", + "image_id": 206476, + "image_name": "21537.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1341.486, + 3318.216, + 1888.9090000000003, + 595.6599999999999 + ], + "priority": 15, + "parents": [ + 153353 + ], + "children": [], + "area": 4451340.308976, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 153368, + "strid": "bc77958a-0450-4bb9-8ad6-fc6ac11d94dd", + "image_id": 206476, + "image_name": "21537.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 233.811, + 3327.9, + 773.212, + 41.47499999999991 + ], + "priority": 16, + "parents": [ + 153353 + ], + "children": [], + "area": 778099.6269, + "iscrowd": 0, + "segmentation": [], + "text": "Text documents FooDrug exploratory analysis" + }, + { + "id": 153365, + "strid": "3d0e1311-6e4c-4cc6-8bf9-ce40410e2a25", + "image_id": 206476, + "image_name": "21537.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 51.16, + 3305.339, + 1120.229, + 344.2750000000001 + ], + "priority": 17, + "parents": [ + 153353 + ], + "children": [ + 153371 + ], + "area": 169101.14323999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 153371, + "strid": "6c0a6161-8a93-4ed7-9994-aa510caa1126", + "image_id": 206476, + "image_name": "21537.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 462.77, + 3665.545, + 709.96, + 251.15200000000004 + ], + "priority": 18, + "parents": [ + 153365 + ], + "children": [], + "area": 1696304.25965, + "iscrowd": 0, + "segmentation": [], + "text": "3a) Search box: Researchers can interrogate food terms’\nfor FDI interactions.\n\n3b) Food-Drug available interactions: A table with\nfood-drug interactions in texts documents is displayed.\n\n3c) Interaction network: Once an experiment is selected a\nnetwork with food-drug interactions is displayed. Central\nnode is the food selected, peripheral nodes are the drugs\nand the edge is the interation in the text." + }, + { + "id": 153366, + "strid": "a9ec66d5-ea8a-4d6f-8b16-931977fc7bcc", + "image_id": 206476, + "image_name": "21537.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 126.979, + 3676.448, + 294.643, + 222.25 + ], + "priority": 19, + "parents": [ + 153353 + ], + "children": [], + "area": 466831.69059199997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 153367, + "strid": "0a5b3a1b-9fef-4615-8f9b-2ab53f6d49e7", + "image_id": 206476, + "image_name": "21537.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 112.29, + 3905.921, + 1032.761, + 423.50300000000016 + ], + "priority": 20, + "parents": [ + 153353 + ], + "children": [ + 153372 + ], + "area": 438595.86909, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 153372, + "strid": "a66d2107-f7b9-4468-8a0c-220f9bb099a5", + "image_id": 206476, + "image_name": "21537.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 135.344, + 4044.565, + 441.85999999999996, + 250.0350000000003 + ], + "priority": 21, + "parents": [ + 153367 + ], + "children": [], + "area": 547407.6053599999, + "iscrowd": 0, + "segmentation": [], + "text": "3d) Interaction table: Once an\nexperiment is selected a table with\nthe text where the interaction is\nmention indisplayed. In blue the food\nand in red the drug,in bold black the\nmention of the interaction. In\naddition, we provide the link to the\ndocument." + }, + { + "id": 153355, + "strid": "f2dd405a-abb8-4223-be9a-e4f91a21e13c", + "image_id": 206476, + "image_name": "21537.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1552.825, + 4374.743, + 224.83300000000008, + 41.98899999999958 + ], + "priority": 22, + "parents": [ + 153374 + ], + "children": [ + 153373 + ], + "area": 6793210.298975001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 153373, + "strid": "8f5120a8-033c-431d-a25f-ee34d56e3c9e", + "image_id": 206476, + "image_name": "21537.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 919.631, + 4484.2, + 2278.589, + 139.55299999999988 + ], + "priority": 23, + "parents": [ + 153355 + ], + "children": [], + "area": 4123809.3301999997, + "iscrowd": 0, + "segmentation": [], + "text": "This research was undertaken by IMDEA Food (IMDEA, ES), a beneficiary in FNS-Cloud, which has received funding from the European\nUnion's Horizon 2020 Research and Innovation programme (H2020-EU.3.2.2.3. —A sustainable and competitive agri-food industry) under\n\nGrant Agreement No. 863059 — www.fns-cloud.eu." + }, + { + "id": 153354, + "strid": "668a0a3d-3e4b-4bb3-adf4-0d184e55c706", + "image_id": 206476, + "image_name": "21537.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2036.727, + 3961.976, + 455.52600000000007, + 42.748999999999796 + ], + "priority": 24, + "parents": [ + 153374 + ], + "children": [ + 153357 + ], + "area": 8069463.492552001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 153357, + "strid": "ece5b12d-8931-400f-b411-659e239d2477", + "image_id": 206476, + "image_name": "21537.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1207.337, + 4046.663, + 2012.062, + 305.12500000000045 + ], + "priority": 25, + "parents": [ + 153354 + ], + "children": [], + "area": 4885685.966431, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 72963, + "strid": "3eb8aceb-b522-4455-94ac-65c5f45bfc8f", + "image_id": 203343, + "image_name": "120074.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 16.64, + 8.86, + 63.599999999999994, + 60.5 + ], + "priority": -1, + "parents": [], + "children": [ + 72941, + 72943, + 72944, + 72939, + 72940, + 72945 + ], + "area": 147.4304, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 72939, + "strid": "b3bfd74d-0039-4660-8c57-8df816fe3508", + "image_id": 203343, + "image_name": "120074.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 142.136, + 18.341, + 477.254, + 53.39900000000001 + ], + "priority": 1, + "parents": [ + 72963 + ], + "children": [], + "area": 2606.916376, + "iscrowd": 0, + "segmentation": [], + "text": "FOCUSED ATTENTION PREDICTS NEURAL PATTERNS\nDURING WORKING MEMORY" + }, + { + "id": 72940, + "strid": "0217ee4a-d3d6-4a21-a25d-974c337c29aa", + "image_id": 203343, + "image_name": "120074.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 192.851, + 91.388, + 390.78100000000006, + 23.531000000000006 + ], + "priority": 2, + "parents": [ + 72963 + ], + "children": [], + "area": 17624.267188, + "iscrowd": 0, + "segmentation": [], + "text": "5. 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Cowan\", C Paaiips *, a}\n‘Heigian Fund of$ejectific Research FURS \"University of Liage’ *Untverst\n\n \n\n‘Stanford University" + }, + { + "id": 72941, + "strid": "ea7795dc-2daf-43d8-b1f7-e220ad929ede", + "image_id": 203343, + "image_name": "120074.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 261.171, + 124.574, + 233.872, + 13.268999999999991 + ], + "priority": 3, + "parents": [ + 72963 + ], + "children": [ + 72942 + ], + "area": 32535.116154, + "iscrowd": 0, + "segmentation": [], + "text": "ATTENTION AND WORKING MEMORY (WM)" + }, + { + "id": 72942, + "strid": "d7e32bf0-1179-4055-8018-93af5fb0772c", + "image_id": 203343, + "image_name": "120074.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 54.407, + 143.828, + 665.737, + 75.61100000000002 + ], + "priority": 4, + "parents": [ + 72941 + ], + "children": [], + "area": 7825.249996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 72943, + "strid": "b4b54bf3-3ba1-455c-90e2-e9e93e9c477b", + "image_id": 203343, + "image_name": "120074.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 341.16, + 239.045, + 71.83300000000003, + 10.329000000000008 + ], + "priority": 5, + "parents": [ + 72963 + ], + "children": [ + 72946 + ], + "area": 81552.5922, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 72946, + "strid": "c07c4746-f010-4b2e-bf24-cb5cf08dbc4e", + "image_id": 203343, + "image_name": "120074.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 52.407, + 259.161, + 648.601, + 27.704999999999984 + ], + "priority": 6, + "parents": [ + 72943 + ], + "children": [], + "area": 13581.850526999999, + "iscrowd": 0, + "segmentation": [], + "text": "hated ahead eclaanalennail henna eeanintel aetna tithe beset beens\nneural patterns in the dorsal attention network when processing WM load in verbal and visual WM tasks.\n\nai dea" + }, + { + "id": 72944, + "strid": "91c0f37f-2afa-43e3-b340-67ef0dae56c5", + "image_id": 203343, + "image_name": "120074.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 95.769, + 306.631, + 124.1, + 11.12700000000001 + ], + "priority": 7, + "parents": [ + 72963 + ], + "children": [ + 72947, + 72958, + 72957, + 72959, + 72956, + 72961, + 72962, + 72960 + ], + "area": 29365.744239, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 72947, + "strid": "7770459f-49e9-4dfa-9c4f-4ef94e6b622a", + "image_id": 203343, + "image_name": "120074.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 45.334, + 326.351, + 237.279, + 164.723 + ], + "priority": 8, + "parents": [ + 72944 + ], + "children": [], + "area": 14794.796234000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 72957, + "strid": "74cd3037-5556-4286-bbcc-e9b98b0f1689", + "image_id": 203343, + "image_name": "120074.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 33.419, + 506.505, + 244.12100000000004, + 169.94299999999998 + ], + "priority": 9, + "parents": [ + 72944 + ], + "children": [ + 72949 + ], + "area": 16926.890594999997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 72949, + "strid": "bd4e7cd3-e204-49a1-ae62-3f35785bfb58", + "image_id": 203343, + "image_name": "120074.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 36.847, + 683.148, + 237.76499999999996, + 49.01599999999996 + ], + "priority": 10, + "parents": [ + 72957 + ], + "children": [], + "area": 25171.954356000002, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2. 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"9429a032-27ef-432f-aef3-274ce5d9b455", + "image_id": 205593, + "image_name": "15380.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 254.742, + 353.087, + 3219.173, + 146.05700000000002 + ], + "priority": 2, + "parents": [ + 131145 + ], + "children": [], + "area": 89946.08855399999, + "iscrowd": 0, + "segmentation": [], + "text": "Abdoallah Sharaf* 12, Roberto De Michele 3, Ayush Sharma 14, Safieh Fakhari ? and Miroslav Obornik 14\n\n1 Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Ceské Budéjovice, Czech Republic. 2 Genetic Department, Faculty of Agriculture, Ain Shams University, Cairo, Egypt.\n3 Institute of Biosciences and Bioresources (IBBR), National Research Council (CNR) of Italy, Palermo, Italy. 4 Faculty of Science, University of South Bohemia, Ceské Budéjovice, Czech Republic." + }, + { + "id": 131119, + "strid": "4ab8f452-0de8-418c-8115-bfb668b2133c", + "image_id": 205593, + "image_name": "15380.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 737.53, + 755.227, + 246.58400000000006, + 46.34400000000005 + ], + "priority": 3, + "parents": [ + 131145 + ], + "children": [ + 131120 + ], + "area": 557002.5693099999, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 131120, + "strid": "040a9f3c-77c0-46a1-9f33-a4cc5850bdff", + "image_id": 205593, + "image_name": "15380.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 281.726, + 866.144, + 1234.8159999999998, + 793.924 + ], + "priority": 4, + "parents": [ + 131119 + ], + "children": [], + "area": 244015.284544, + "iscrowd": 0, + "segmentation": [], + "text": "The heavy metal pollution in ecosystems is of increasing global concern. The main sources\nof the metal toxicity are the industrial waste, mining and using of pesticides; which\nincludes heavy metals. Out of all heavy metals, mercury (Hg) is considered to be the one,\neasily accumulated in the aquatic organism. Hg can induce more severe oxidative stress by\ntriggering production of reactive oxygen species (ROS) and damage macro-molecules. ROS\nserve not only as dangerous molecules that damage proteins, lipids and DNA but also as\nsignaling molecules in the regulation of biological processes such as biotic and abiotic\nstress responses. Xenobiotics detoxification pathway “Green Liver-like” is another defense\nsystem, which can activate due to heavy metal stress. This study aims to explore the\nchange in the Chromera velia transcriptome due to Hg stress; C. velia is the recently\ndiscovered closest known relative of Apicomplexans. The results show that 1239 genes\ndifferentially expressed; Differentially Expressed Genes (DEGs) showed overall up-\nregulation (1,070 genes) while only 169 genes were down-regulated. Moreover, 145 ROS-\nmediated related unigenes identified; of them, 125 (86.2 %) unigenes were showed similar\nexpression patterns while 20 showed Differential Expression (DE) patterns. Out of 126\nxenobiotics metabolism related identified unigenes; only fifteen (11.9 %) unigenes showed\nDE patterns while 111 (88.1 %) unigenes showed similar expression patterns. Our study\npresents the first deep transcriptomic analysis of C. velia, focusing on the expression level\nof genes involved in various detoxification defense systems in response to heavy metal\nstress." + }, + { + "id": 131121, + "strid": "308181a5-72b5-4239-a8bd-f05cdd1c2e6d", + "image_id": 205593, + "image_name": "15380.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2595.41, + 725.781, + 207.73900000000003, + 44.09299999999996 + ], + "priority": 5, + "parents": [ + 131145 + ], + "children": [ + 131122, + 131123 + ], + "area": 1883699.2652099999, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 131122, + "strid": "3a899b67-8540-4491-9d6d-ae1613b0d143", + "image_id": 205593, + "image_name": "15380.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2145.22, + 772.542, + 1011.5549999999998, + 812.7989999999999 + ], + "priority": 6, + "parents": [ + 131121 + ], + "children": [], + "area": 1657272.5492399998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 131123, + "strid": "c3de0116-67af-4eda-b323-0c77ac013e1a", + "image_id": 205593, + "image_name": "15380.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2145.471, + 1595.701, + 1038.1640000000002, + 243.0039999999999 + ], + "priority": 7, + "parents": [ + 131121 + ], + "children": [], + "area": 3423530.220171, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 131124, + "strid": "496557d9-98a7-405b-b02f-7cff35eda775", + "image_id": 205593, + "image_name": "15380.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1620.865, + 1944.134, + 305.58500000000004, + 44.618999999999915 + ], + "priority": 8, + "parents": [ + 131145 + ], + "children": [ + 131127, + 131126, + 131125 + ], + "area": 3151178.75591, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion" + }, + { + "id": 131125, + "strid": "f375f733-8c05-48a3-af8a-e7eebcc181d1", + "image_id": 205593, + "image_name": "15380.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1095.468, + 2059.337, + 1364.213, + 432.6640000000002 + ], + "priority": 9, + "parents": [ + 131124 + ], + "children": [], + "area": 2255937.7847160003, + "iscrowd": 0, + "segmentation": [], + "text": "This is the first study on the responses of the protist C. velia to Hg** treatment. By combining physiological, biochemical,\ntranscriptomic and bioinformatical analyses, we were able to uncover several pathways activated in response to the\nheavy metal stress. In general, we observed that C. velia behaves like higher plant species in terms of ROS production,\nwith a reduction in H,O, and an increase in -O* levels at high concentrations of Hg”. Conversely, RNS do not seem to\nplay a role, a fact that discriminates markedly Hg** from other heavy metal responses, such as cadmium. This is also the\nfirst transcriptomic analysis of C. velia altogether, an important organism for phylogenetic studies, and a model\nmicroalga. In total, 122,874 transcripts and 68,713 unigenes were successfully annotated in databases. Moreover, the\n1,239 differentially expressed unigenes in C. velia were useful to postulate the molecular pathways involved in Hg**\nresponse, such as different detoxification defense systems and TFs. Importantly, variation in expression of genes\ninvolved in ROS detoxifications generally matched with our biochemical observation of ROS levels, corroborating the\nvalidity of our dual approach. Eventually, the qPCR expression analysis exhibited a positive correlation with the findings\nof biochemical and RNA-seq data. Overall, our data indicate that the response of C. velia to Hg’* involves changes in\nvarious aspects of cell metabolism, signaling, and transport." + }, + { + "id": 131126, + "strid": "40f50482-5a4a-4b51-9b0a-77b0ff417dce", + "image_id": 205593, + "image_name": "15380.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1006.355, + 2492.539, + 784.1210000000001, + 576.3250000000003 + ], + "priority": 10, + "parents": [ + 131124 + ], + "children": [], + "area": 2508379.085345, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 131127, + "strid": "aa901102-f35d-4a34-afde-afa0f669e202", + "image_id": 205593, + "image_name": "15380.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1810.519, + 2512.41, + 652.0710000000001, + 457.34900000000016 + ], + "priority": 11, + "parents": [ + 131124 + ], + "children": [], + "area": 4548766.04079, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 131128, + "strid": "e5312858-cf4e-495d-a287-d2d13ecda199", + 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"priority": 24, + "parents": [ + 131145 + ], + "children": [], + "area": 7628166.048727999, + "iscrowd": 0, + "segmentation": [], + "text": "EUROPEAN UNION\n\nEuropean Structural and Investment Funds\nOperational Programme Research,\nDevelopment and Education" + }, + { + "id": 131141, + "strid": "a3747a34-2551-48b8-bc4c-3688b63d5a4a", + "image_id": 205593, + "image_name": "15380.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2916.616, + 4616.246, + 227.8209999999999, + 56.302999999999884 + ], + "priority": 25, + "parents": [ + 131145 + ], + "children": [ + 131143 + ], + "area": 13463816.943536, + "iscrowd": 0, + "segmentation": [], + "text": "Funding" + }, + { + "id": 131143, + "strid": "88f8b069-063c-4230-8504-1ab5d5184146", + "image_id": 205593, + "image_name": "15380.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2408.599, + 4698.36, + 1145.034, + 87.35199999999986 + ], + "priority": 26, + "parents": [ + 131141 + ], + "children": [], + 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9, + "category_name": "Root", + "bbox": [ + 128.74, + 25.64, + 153.57999999999998, + 70.64 + ], + "priority": -1, + "parents": [], + "children": [ + 152821, + 152818, + 152820, + 152819, + 152816, + 152822, + 152823, + 152817, + 152815 + ], + "area": 3300.8936000000003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 152815, + "strid": "6d9c26f1-cd38-4a4a-a490-019e3ef3c34c", + "image_id": 206450, + "image_name": "21470.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 330.989, + 14.066, + 2535.038, + 51.92999999999999 + ], + "priority": 1, + "parents": [ + 152839 + ], + "children": [], + "area": 4655.691274, + "iscrowd": 0, + "segmentation": [], + "text": "NOMA-DB: A FRAMEWORK FOR MANAGEMENT AND ANALYSIS OF AGEING-RELATED GENE-EXPRESSION DATA." + }, + { + "id": 152816, + "strid": "03223930-c246-49b6-926b-b13d6557f17a", + "image_id": 206450, + "image_name": "21470.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 899.296, + 98.034, + 1372.428, + 116.355 + ], + "priority": 2, + "parents": [ + 152839 + ], + "children": [], + "area": 88161.58406400001, + "iscrowd": 0, + "segmentation": [], + "text": "Pietro Hiram Guzzi’, Ugo Lomoio’, Rocco Scicchitano’, Pierangelo Veltri’\n*Magna Graecia University of Catanzaro" + }, + { + "id": 152817, + "strid": "a169388f-55ff-47f3-951c-f572c312f799", + "image_id": 206450, + "image_name": "21470.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 332.477, + 325.195, + 151.046, + 27.25600000000003 + ], + "priority": 3, + "parents": [ + 152839 + ], + "children": [ + 152824 + ], + "area": 108119.85801499999, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 152824, + "strid": "f229ee83-14fd-4bcc-96c0-c7d98816f92d", + "image_id": 206450, + "image_name": "21470.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 67.795, + 360.433, + 689.251, + 647.025 + ], + "priority": 4, + "parents": [ + 152817 + ], + "children": [], + "area": 24435.555235, + "iscrowd": 0, + "segmentation": [], + "text": "Recently, many independent research projects focus on\nthe study of the molecular basis of ageing processes. In\nparallel, the progression of many diseases with respect to\ndifferent gender is a hot topic research area. These\nstudies require many data, models and tools for inferring\nageing and gender-specific molecular data. Among the\nothers, the Genotype-Tissue Expression (GTEx) database\nis one of the preeminent resources for the analysis of\ngene expression data related to tissues, sex and age.\n\nGTEx Portal has query interfaces that enable gene\nexpression analysis on different tissues. Despite this,\nGTEx Portal lacks on analysis at the gender/age level.\nMoreover, it lacks on the integration with existing protein-\nprotein interaction (PPI) data.\n\nTo overcome these limitations, we here present NOMA-\nDB, a framework for the analysis of age-related genes.\nThis framework is based on the GTEx database and allows\nthe user to query GTEx data filtered by using sex, age and\ntissue and to retrieve the corresponding PPI subnetwork." + }, + { + "id": 152818, + "strid": "6198eb4f-acf0-464f-850f-2325efdb108a", + "image_id": 206450, + "image_name": "21470.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 309.86, + 1044.692, + 205.60699999999997, + 25.604000000000042 + ], + "priority": 5, + "parents": [ + 152839 + ], + "children": [ + 152825 + ], + "area": 323708.26312, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 152825, + "strid": "d90261b8-0bb3-4c90-babe-b994c099c714", + "image_id": 206450, + "image_name": "21470.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 61.29, + 1081.022, + 695.158, + 644.905 + ], + "priority": 6, + "parents": [ + 152818 + ], + "children": [], + "area": 66255.83838, + "iscrowd": 0, + "segmentation": [], + "text": "Ageing is commonly defined as the process of becoming\nolder. In humans, ageing represents the progressive\ninsurgence and accumulation of changes over time. Ageing\nstudies focus on disclosing genomic and epigenomics\nchanges related to these changes. The rationale of these\nstudies is that elucidating these mechanisms can also help\ndevelop novel therapies for many diseases related to\nageing [1].\n\nIt is possible to evidence some main key points enabling\nresearch in ageing processes: (i) the availability of data in\npublic databases; (ii) the introduction of standards related\nto data modeling and exchange; (iii) the development of\nmethods and models for data integration and analysis,\nGTEx database [2] represents one of the most used\nresources for collecting data related to whole-genome\nsequencing and RNA-seq in individuals. For each sample,\nGTEx provides information such as tissue of provenance,\nsex, and age (grouped into six interval classes) of the\npatient." + }, + { + "id": 152819, + "strid": "04c1af1e-974a-486b-bafc-303781e6da78", + "image_id": 206450, + "image_name": "21470.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1136.898, + 327.076, + 130.87400000000002, + 25.112000000000023 + ], + "priority": 7, + "parents": [ + 152839 + ], + "children": [ + 152826, + 152827, + 152829 + ], + "area": 371852.050248, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 152826, + "strid": "44555e23-19f3-48b3-8b3e-2b93bb5b73c2", + "image_id": 206450, + "image_name": "21470.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 864.304, + 359.074, + 690.716, + 505.1820000000001 + ], + "priority": 8, + "parents": [ + 152819 + ], + "children": [], + "area": 310349.094496, + "iscrowd": 0, + "segmentation": [], + "text": "To overcome GTEx Portal limitations we designed NOMA-\nDB (Network OMics Ageing Database), a framework able\nto gather data from the GTEx database and PPI databases.\nSuch data are then made available to the user through a\nweb interface. The user can query the GTEx database and\nanalyze data by sex and age through the web interface.\nMoreover, expression data are integrated into the existing\nprotein interaction network to enable network-based\nanalysis and visualization. Thus, the NOMA-DB framework\nallows the user to perform tissue-level ageing studies.\n\nThe NOMA-DB architecture comprises the following\nmodules as depicted in Figure 1: (i) the GTEx Manager, (ii)\nthe GTEx (local) DB, (iii) the PPI-DB integrator, (iv) the PPI-\nDB (local) database, (v) the network analysis module, (vi)\nthe query builder, and (vii) the web interface." + }, + { + "id": 152827, + "strid": "e26130ee-2541-4e2e-8ecd-2744241371df", + "image_id": 206450, + "image_name": "21470.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 912.751, + 864.272, + 581.9370000000001, + 355.6150000000001 + ], + "priority": 9, + "parents": [ + 152819 + ], + "children": [ + 152828 + ], + "area": 788865.1322720001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 152828, + "strid": "1299b548-9d2c-4eeb-a59a-d7ad65d1e98c", + "image_id": 206450, + "image_name": "21470.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1026.808, + 1228.85, + 388.26199999999994, + 26.241999999999962 + ], + "priority": 10, + "parents": [ + 152827 + ], + "children": [], + "area": 1261793.0107999998, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1: NOMA-DB framework architecture" + }, + { + "id": 152829, + "strid": "fdb11479-3682-4075-b697-2d9f79039412", + "image_id": 206450, + "image_name": "21470.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 863.054, + 1272.202, + 694.792, + 469.58400000000006 + ], + "priority": 11, + "parents": [ + 152819 + ], + "children": [], + "area": 1097979.024908, + "iscrowd": 0, + "segmentation": [], + "text": "The current version of this framework uses MySQL 8.0\ndatabase to store data. The GTEx DB and the PPI-DB are,\nrespectively, local copies of the GTEx and PPI public\ndatabases. The GTEx Manager and the PPI DB Integrator\nare responsible for updating the local databases with the\ndata crawled from the public databases. These two\nintegrator modules are written in Python and use\nPyMySQL connector and requests libraries. The Query\nBuilder module is responsible to build a MySQL query\nbased on the user interactions in the web interface. The\nweb interface is a responsive HTML5-based client with\nJavascript, Bootstrap, and CSS. The front end has been\nrealized using Angular, the back end has been realized\nusing Django-rest-framework and Django-cors-headers." + }, + { + "id": 152820, + "strid": "9c23f871-66b6-4c80-a4b8-1f06a4fcadc3", + "image_id": 206450, + "image_name": "21470.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1932.071, + 327.533, + 125.33899999999994, + 24.451999999999998 + ], + "priority": 12, + "parents": [ + 152839 + ], + "children": [ + 152833, + 152830, + 152831, + 152834 + ], + "area": 632817.010843, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 152830, + "strid": "6a38ef94-39b2-4395-a159-90ee46cdb133", + "image_id": 206450, + "image_name": "21470.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1651.373, + 365.287, + 693.098, + 307.87999999999994 + ], + "priority": 13, + "parents": [ + 152820 + ], + "children": [], + "area": 603225.089051, + "iscrowd": 0, + "segmentation": [], + "text": "This section shows the usage of the NOMA-DB framework\nto study a subset of genes related to type 2 diabetes\ninsurgence and progression. We selected all gene names\nrelated to diabetes from the T2DiaCoD database [3] (650\ngenes) and then we used NOMA-DB to retrieve their\nexpression.\n\nAfter selecting the list of genes to analyze, the user can\nselect, using the web interface in Figure 2, the following\nparameters: Tissue, Age Interval, and Sex." + }, + { + "id": 152831, + "strid": "45741e90-8886-457a-877a-a2b6180b3688", + "image_id": 206450, + "image_name": "21470.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1643.596, + 678.659, + 704.982, + 362.82499999999993 + ], + "priority": 14, + "parents": [ + 152820 + ], + "children": [ + 152832 + ], + "area": 1115441.217764, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 152832, + "strid": "0fdede14-1db7-4b4a-bb9c-03ecbb0dfbd0", + "image_id": 206450, + "image_name": "21470.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1846.799, + 1048.244, + 304.4180000000001, + 26.366999999999962 + ], + "priority": 15, + "parents": [ + 152831 + ], + "children": [], + "area": 1935895.9709559998, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2: NOMA-DB Web Interface" + }, + { + "id": 152833, + "strid": "ed148f62-48a7-4cb4-a85d-2ed986c3abc6", + "image_id": 206450, + "image_name": "21470.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1653.093, + 1079.95, + 692.7819999999999, + 202.92000000000007 + ], + "priority": 16, + "parents": [ + 152820 + ], + "children": [], + "area": 1785257.7853500003, + "iscrowd": 0, + "segmentation": [], + "text": "For example, the user selects the following parameters:\nTissue = “Liver”, sex = \"M\" and Age = \"20-29\". When the\nuser presses the Execute button, our query builder builds\nand execute the following MySQL query on our local DB:\nselect *, from gtex , where Tissue='Liver’ and sex ='M' and\nAge='20-29'" + }, + { + "id": 152834, + "strid": "6665d66e-ef0f-4560-8b4a-4517eda39d13", + "image_id": 206450, + "image_name": "21470.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1646.918, + 1281.993, + 703.8500000000001, + 385.57400000000007 + ], + "priority": 17, + "parents": [ + 152820 + ], + "children": [ + 152835 + ], + "area": 2111337.347574, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 152835, + "strid": "32c377e2-2383-4d30-a51b-970fa286bfb9", + "image_id": 206450, + "image_name": "21470.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1674.458, + 1671.565, + 643.134, + 52.450000000000045 + ], + "priority": 18, + "parents": [ + 152834 + ], + "children": [], + "area": 2798965.38677, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3: NOMA-DB case of usage: all genes related to type 2 diabetes in\nMale patients with age 20-29 and in Liver tissue." + }, + { + "id": 152821, + "strid": "0488fb62-ab8a-412b-bcb6-f0a66d69fbf9", + "image_id": 206450, + "image_name": "21470.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2686.3, + 324.297, + 202.00700000000006, + 27.531999999999982 + ], + "priority": 19, + "parents": [ + 152839 + ], + "children": [ + 152836 + ], + "area": 871159.0311000001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 152836, + "strid": "87290605-913c-48b7-b1c3-4bf6f17a3156", + "image_id": 206450, + "image_name": "21470.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2445.068, + 403.344, + 689.779, + 669.712 + ], + "priority": 20, + "parents": [ + 152821 + ], + "children": [], + "area": 986203.507392, + "iscrowd": 0, + "segmentation": [], + "text": "Recently the interest in investigating sex and age-based\ndifferences on disease insurgence and progression is\nincreasing. These studies need a deep knowledge of\nmolecular mechanisms and their differences among\nindividuals. These data should be contained in publicly\navailable databases. There exist some efforts in this\ndirection, such as the GTEx database. Despite this, there is\na need for specialized query interfaces and integration\nwith existing protein interaction data. We here presented\nNOMA-DB, a framework for analyzing age-related genes\nthat enable easy querying at sex/age level and network-\nbased analysis. Future work will regard from one side the\nextension of this database and, on the other side, the use\nof the use of this data for a better comprehension of\nageing/sex-related molecular machinery based on the\nanalysis of expression data. With our framework, users\nmay also calculate gene expression median values by age\nand use them as an indicator of progressions. Currently,\nthe results of these values and the clinical interpretation\nare the object of a parallel study." + }, + { + "id": 152823, + "strid": "3ae7cdf2-e1df-4a53-a669-3d9c5ecea0de", + "image_id": 206450, + "image_name": "21470.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2664.778, + 1461.437, + 251.96799999999985, + 28.19900000000007 + ], + "priority": 21, + "parents": [ + 152839 + ], + "children": [ + 152838 + ], + "area": 3894405.1659859996, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 152838, + "strid": "7fa6dc61-1433-4471-9fda-beba4a2f4dad", + "image_id": 206450, + "image_name": "21470.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2449.781, + 1513.892, + 680.6970000000001, + 109.52999999999997 + ], + "priority": 22, + "parents": [ + 152823 + ], + "children": [], + "area": 3708703.857652, + "iscrowd": 0, + "segmentation": [], + "text": "PNG, UL and PV were partially funded by the MISE PON-\nVQA project.\nUL PhD fellow is partially supported by Relatech S.p.A." + }, + { + "id": 152822, + "strid": "308d904e-472f-4652-aaab-9f2407b94ed2", + "image_id": 206450, + "image_name": "21470.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2697.541, + 1087.448, + 185.45400000000018, + 25.99499999999989 + ], + "priority": 23, + "parents": [ + 152839 + ], + "children": [ + 152837 + ], + "area": 2933435.5653680004, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 152837, + "strid": "1fa4272e-0148-44ae-99a7-cd9ba8da2145", + "image_id": 206450, + "image_name": "21470.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2441.148, + 1131.231, + 686.7579999999998, + 315.96399999999994 + ], + "priority": 24, + "parents": [ + 152822 + ], + "children": [], + "area": 2761502.293188, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 50254, + "strid": "100290c4-c3d1-42ec-a9eb-e98adabc8faf", + "image_id": 202473, + "image_name": "118747.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 327.11, + 661.96, + 158.49, + 178.30999999999995 + ], + "priority": -1, + "parents": [], + "children": [ + 50251, + 50239, + 50241, + 50238, + 50237, + 50240 + ], + "area": 216533.7356, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 50237, + "strid": "643f07b0-11ab-49d8-a44e-91cf76ccae82", + "image_id": 202473, + "image_name": "118747.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 176.598, + 243.501, + 2302.014, + 105.85499999999999 + ], + "priority": 1, + "parents": [ + 50254 + ], + "children": [], + "area": 43001.789598, + "iscrowd": 0, + "segmentation": [], + "text": "CROSS-CORRELATION OF PAIN HYPERSENSITIVITY AND FUNCTIONAL AND IMAGING\nPARAMETERS IN EARLY PHASE OF CHRONIC LBP" + }, + { + "id": 50238, + "strid": "f567d77a-f041-4141-9b32-f3a998ae33ca", + "image_id": 202473, + "image_name": "118747.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 824.285, + 461.659, + 1118.0880000000002, + 404.635 + ], + "priority": 2, + "parents": [ + 50254 + ], + "children": [], + "area": 380538.58881499997, + "iscrowd": 0, + "segmentation": [], + "text": "Konstantinovié Ljubica,” \\jubica.konstantinovic@mfub.bg.ac.rs, Olivera Djordjevié,’”\nodordev@Eunet.rs,Nadica Miljkovic *° nadica.miljkovic@etf.rs, Goran Bijelié°\ngoran.bijelic@etf.rs, Laslo Svirtlih * \\aslo.svirtlin@gmail.com, Dejan B. Popovic, **\n\ndbp@etf.rs, Haritz Zabaleta, °haritz.zabaleta@tecnalia.com\n\n1. Faculty of Medicine Univeristy of Belgrade, Dr Subotica 6, Belgrade, Serbia\n2. Clinic for rehabilitation dr Miroslav Zotovic, Sokobanjska 13, Belgrade, Serbia\n3. Faculty of Electrical Engineering, University of Belgrade, Bulevar kralja Aleksandra 73,\n11000, Belgrade, Serbia\n4. Department of Health Science and Technology, Aalborg University, Denmark (Fredrik\nBajers Vej 7, DK-9220 Aalborg, Denmark\n5. Tecnalia Serbia Ltd. Viadetina 13/6 Belgrade, Serbia\n6. Health Unit, Tecnalia, Donostia, Paseo Mikeletegi 1-3, Parque Technologico, San Sebastian Spain" + }, + { + "id": 50239, + "strid": "559b3aa9-13aa-41d9-a8a0-5d172c59d223", + "image_id": 202473, + "image_name": "118747.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 213.389, + 1009.394, + 357.519, + 34.71199999999999 + ], + "priority": 3, + "parents": [ + 50254 + ], + "children": [ + 50242 + ], + "area": 215393.57626600002, + "iscrowd": 0, + "segmentation": [], + "text": "Background and aims:" + }, + { + "id": 50242, + "strid": "b5deaeec-91fd-47ac-9da6-f6cf71c7f7ad", + "image_id": 202473, + "image_name": "118747.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 213.433, + 1099.225, + 1108.149, + 401.6680000000001 + ], + "priority": 4, + "parents": [ + 50239 + ], + "children": [], + "area": 234610.88942499997, + "iscrowd": 0, + "segmentation": [], + "text": "Diagnostic and prognostic value of pain hypersensitivity in low back pain (LBP)\n\nis not fully understood. Increased pain sensitivity in the primary area of pain\n\n(local pain) is considered a sign of predominantly peripheral pain sensitization,\n\nwhereas pain sensitivity in distal and remote areas is considered to present a more central\nphenomenon. It is suggested that patients with enhanced pain sensitivity report high level\nof disability. Despite fact that pain and disability are associated in chronic LBP the exact\nmechanisms of sensitivity contribution in LBP disability is unknown. It has also been\nsuggested that muscle function changes may be driven by pain. The possible role and\ncontribution of trunk muscles function to pain and disability phenomena remain unknown.\n\nThis study was aimed to estimate prevalence and possible correlation among pain\nhypersensitivity and functional and imaging parameters of trunk muscles in patients\nreporting early phase of chronic LBP." + }, + { + "id": 50240, + "strid": "4f74ca84-3e22-46c0-841d-0642f858903a", + "image_id": 202473, + "image_name": "118747.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 217.2, + 1573.377, + 146.406, + 26.682999999999993 + ], + "priority": 5, + "parents": [ + 50254 + ], + "children": [ + 50244, + 50243, + 50253 + ], + "area": 341737.48439999996, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 50253, + "strid": "c3531b59-2bd3-4c9f-b252-db4698d60003", + "image_id": 202473, + "image_name": "118747.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 213.867, + 1659.839, + 983.7730000000001, + 469.52800000000025 + ], + "priority": 6, + "parents": [ + 50240 + ], + "children": [], + "area": 354984.78741299995, + "iscrowd": 0, + "segmentation": [], + "text": "Cross sectional study was performed on 14 randomly selected patients in early\nphase of chronic LBP, aged 38-65 years. The study was carried out between\nJanuary 2013 and April 2013 at Clinic for Rehabilitation of The Medical School\nUniversity of Belgrade, Serbia. During this period, 56 patients with subacute\nLBP and associated radiculopathy were assessed for eligibility. Including criteria\nwere pain for at least 12 weeks, caused by prolapsed intervertebral disc (PID),\nconfirmed by magnetic resonance imaging (MRI), no meeting excluding criteria.\nExcluding criteria were no response to initial contact, red flag symptoms,\ndiabetes mellitus, neurological problems and cancer; pregnant patients and\npatients treated chirurgically for the same problem or treated with oral\ncorticosteroids and steroid injections for any reason in the previous month.\nDiagnosis was made by clinical examination and additional neuroradiological\nand neurophysiological examinations All the patients gave informed written\nconsent to participate in the study, which was approved by the ethics committee\nof the Clinic for Rehabilitation of Medical School University of Belgrade." + }, + { + "id": 50243, + "strid": "6c1b9c82-9955-4b77-befe-02b2fde9e962", + "image_id": 202473, + "image_name": "118747.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 215.052, + 2159.698, + 993.0369999999999, + 775.3669999999997 + ], + "priority": 7, + "parents": [ + 50240 + ], + "children": [], + "area": 464447.37429599994, + "iscrowd": 0, + "segmentation": [], + "text": "The parameters assessed include pressure pain detection threshold (PPDT),\npressure pain tolerance threshold (PPTT) at the site of maximal pain and\n\nof more distant nonpainful point at the back, and the ipsilateral great toe,\npain intensity (VAS), Oswestry disability score (DS), Beck depression score,\namplitude on surface EMG and US thickness of multifidus\n\n(M) and transversus abdominals (TrA) (table 1)\n\nPain hypersensitivity was assessed using a pressure algometer\n\n(Somedic AB, Horby, Sweden). Pressure was applied using a probe with an area\nof 1 cm’ and intensity to a maximum of 1,000 kPa at a rate of 30 kPa/s.\n\nEMG signals were recorded with wireless LUMBIA system\n\n(BTS Bioengineering, Padova, Italy) on Transversus regia (TrA) and on\nMultifidus (M) muscles with surface EMG F-TC1 electrodes Skintact,\nInnsbruck, Austria) placed according to SENIAM protocol. The reference\nelectrode was placed over the thoracic T12 vertebrae. Ultrasound scanner\nToshiba Diagnostic Ultrasound System Nemio SSA-550A was used with\ncurvilinear 3.75 MHz transducer to measure muscle thickness. The muscle\nthickness and EMG amplitude from left and right M and TrA were measured\nduring relaxation and voluntary contraction (submaximal contraction).\n\nThe subjects were instructed to rise opposite arm over the head for the activation\nof the appropriate M muscle in prone position as much as they could.\n\nDuring the recordings of voluntary contraction of TrA muscles, subjects were\ninstructed to tighten their belly during the expiration in supine position.\nAveraged muscle thickness (\"diff\") and EMG amplitude (\"RMS ratio\")\nparameters variation calculated during two recording sessions in all subjects\nand expressed in percents. Statistical analyses were done with SPSS 11.5." + }, + { + "id": 50244, + "strid": "0234db82-9797-4d5e-b0e7-1230568f07ee", + "image_id": 202473, + "image_name": "118747.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 253.236, + 3161.131, + 916.1939999999998, + 332.16600000000017 + ], + "priority": 8, + "parents": [ + 50240 + ], + "children": [ + 50245 + ], + "area": 800512.169916, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 50245, + "strid": "8d151471-fa62-4b5d-bbbc-08dc72da2ce6", + "image_id": 202473, + "image_name": "118747.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 259.959, + 3094.479, + 902.0889999999999, + 48.61900000000014 + ], + "priority": 9, + "parents": [ + 50244 + ], + "children": [], + "area": 804437.6663609999, + "iscrowd": 0, + "segmentation": [], + "text": "Table 2: Spearman's correlation coefficient of pain sensitivity parameters with\nimaging (EMG, US) parameters" + }, + { + "id": 50241, + "strid": "0f162b7b-a367-4a65-9783-0ea8016c1911", + "image_id": 202473, + "image_name": "118747.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2204.914, + 1008.796, + 380.87300000000005, + 26.40599999999995 + ], + "priority": 10, + "parents": [ + 50254 + ], + "children": [ + 50246, + 50250, + 50247 + ], + "area": 2224308.4235440004, + "iscrowd": 0, + "segmentation": [], + "text": "Results and discussion:" + }, + { + "id": 50246, + "strid": "e3f375d7-b3b3-4e79-b284-25d4fe3d3578", + "image_id": 202473, + "image_name": "118747.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1381.919, + 1073.375, + 1204.6900000000003, + 368.5930000000001 + ], + "priority": 11, + "parents": [ + 50241 + ], + "children": [], + "area": 1483317.3066250002, + "iscrowd": 0, + "segmentation": [], + "text": "Descriptive statistics of parameters is presented on Table 1. Positive correlation between\nPPDT on most painful site and US thickness of ipsilateral TrA (p = 0.600; p = 0.023) (Table 2)\nand negative correlation between PPTT on great toe with ipsilateral M ( p = -0.538; p = 0.047)\nwere found. Negative correlation with leg pain was found for all pain parameters and for\nPPTT on painful site and Oswestry score (p = - 0.692; p = 0.006) (Table 3).\n\nThese results highlighted important association between pain sensitivity parameters and\n\nmuscle function in early phase of chronic LBP as in chronic pain condition. A better\n\nunderstanding of the relationship between clinical features of spinal pain and pain\n\nsensitivity, as well as relationship between pain and muscles function is consider as an\n\nimportant for further development of diagnostic and treatment strategy. Further research\n\nshould be include contro! group of healthy subjects and larger sample size to confirm this findings." + }, + { + "id": 50247, + "strid": "3719b2f9-95cd-4a28-83aa-5acc73b62000", + "image_id": 202473, + "image_name": "118747.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1611.163, + 1763.94, + 816.5219999999999, + 429.25099999999975 + ], + "priority": 12, + "parents": [ + 50241 + ], + "children": [ + 50248 + ], + "area": 2841994.86222, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 50248, + "strid": "ffdce85b-fedc-4d18-8474-37798a940cab", + "image_id": 202473, + "image_name": "118747.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1619.367, + 1715.984, + 465.8459999999998, + 22.182999999999993 + ], + "priority": 13, + "parents": [ + 50247 + ], + "children": [], + "area": 2778807.862128, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1: Descriptive statistics of parameters" + }, + { + "id": 50250, + "strid": "a3c341f5-ec55-4b05-8a8c-a9c68c60348d", + "image_id": 202473, + "image_name": "118747.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1503.182, + 2615.168, + 1031.7629999999997, + 252.7739999999999 + ], + "priority": 14, + "parents": [ + 50241 + ], + "children": [ + 50249 + ], + "area": 3931073.4645760003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 50249, + "strid": "48cf95b8-7a38-4245-a971-8e85ba13d492", + "image_id": 202473, + "image_name": "118747.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1510.913, + 2504.564, + 902.502, + 48.28099999999995 + ], + "priority": 15, + "parents": [ + 50250 + ], + "children": [], + "area": 3784178.306932, + "iscrowd": 0, + "segmentation": [], + "text": "Table 3: Spearman rho correlation coefficient of pain sensitivity parameters and pain\nintensity, disability score and depression scores." + }, + { + "id": 50251, + "strid": "bb250985-c60b-4eca-9f34-965b90e03479", + "image_id": 202473, + "image_name": "118747.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2373.773, + 3173.995, + 209.11599999999999, + 26.50799999999981 + ], + "priority": 16, + "parents": [ + 50254 + ], + "children": [ + 50252 + ], + "area": 7534343.633135, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions:" + }, + { + "id": 50252, + "strid": "e7115737-0435-47b3-9abf-03c79d09eee0", + "image_id": 202473, + "image_name": "118747.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1503.789, + 3254.206, + 1079.8659999999998, + 85.0300000000002 + ], + "priority": 17, + "parents": [ + 50251 + ], + "children": [], + "area": 4893639.186534001, + "iscrowd": 0, + "segmentation": [], + "text": "These results provide evidence of significant association between pain\nhypersensitivity parameters and disability, and pain hypersensitivity and US thickness of\ntrunk muscles in early phase of chronic LBP patients" + }, + { + "id": 63741, + "strid": "b6d7b961-ea33-499e-87b9-0e6ff78e7cd9", + "image_id": 203009, + "image_name": "119577.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 231.32, + 297.68, + 247.65000000000003, + 267.46 + ], + "priority": -1, + "parents": [], + "children": [ + 63739, + 63677, + 63736, + 63680, + 63679, + 63740, + 63700, + 63678, + 63692, + 63738, + 63681 + ], + "area": 68859.3376, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 63677, + "strid": "023a2f2d-02fc-42f3-886e-345642efc905", + "image_id": 203009, + "image_name": "119577.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 698.057, + 131.404, + 2025.0290000000002, + 374.693 + ], + "priority": 1, + "parents": [ + 63741 + ], + "children": [], + "area": 91727.482028, + "iscrowd": 0, + "segmentation": [], + "text": "Research to policy.and practice change:\ne is Capacity buvtding in operational\nresearch délivering the goods?" + }, + { + "id": 63678, + "strid": "81718b36-98d8-4c7d-8984-31326484d151", + "image_id": 203009, + "image_name": "119577.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 148.604, + 827.091, + 3071.355, + 298.33000000000004 + ], + "priority": 2, + "parents": [ + 63741 + ], + "children": [], + "area": 122909.030964, + "iscrowd": 0, + "segmentation": [], + "text": "Zachariah R', Guillernm N2, Berger Kumar AMV2, Satyanarayana S2,Bissell K23, Edginton M4, Hinderak 5, Tayler-Smith K},\n. van den Ber Khogali M', Manzi M', Reid AJé\\Ramsay A’, Reeder JC’, Harney 8\n\nJohannesburg, South Afric niversity of Bergen, Norway 6.Institute ofTropical Medicine, Antwerp, Belgium 7.VV; ealth Organisation Geneva,\n\n1.Medecins Sans Frontieres 2 goySchationa Union Against TB and Lung Dj he 3. 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Mattingley & Ross Cunnington\n\nQueensland Brain Institute*& School of Psychology, The University of Queensland, Brisbane, Australia" + }, + { + "id": 35605, + "strid": "4e85b740-f22c-481a-a7a0-ebfdc95d213d", + "image_id": 201905, + "image_name": "117856.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 481.643, + 565.433, + 276.32199999999995, + 48.57600000000002 + ], + "priority": 3, + "parents": [ + 35627 + ], + "children": [ + 35609 + ], + "area": 272336.846419, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 35609, + "strid": "5b2627fe-e705-4205-ab16-6f466ba68bfe", + "image_id": 201905, + "image_name": "117856.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 107.706, + 653.605, + 974.1639999999999, + 619.5799999999999 + ], + "priority": 4, + "parents": [ + 35605 + ], + "children": [], + "area": 70397.18013000001, + "iscrowd": 0, + "segmentation": [], + "text": "The natural environment is busy and visually cluttered. Attention\nand predictions help us to process relevant information and filter\nout noise from the environment. In an everyday situation we still\nprocess our surroundings even when our attention is on a\ndemanding task; however, not much is known about the\nunderlying mechanisms. Here we investigated the neural\nrepresentation of unattended actions while participants were\nfocussed on an attentionally demanding visual task. We\nmanipulated action properties to be repeated or novel relative to\nthe previous action and measured how predictive forces are\n\nrepresented in neural! activity." + }, + { + "id": 35606, + "strid": "dffb5280-062c-4077-ae2f-39dc120e7c6f", + "image_id": 201905, + "image_name": "117856.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 361.033, + 1342.97, + 515.793, + 55.75999999999999 + ], + "priority": 5, + "parents": [ + 35627 + ], + "children": [ + 35611, + 35610, + 35626, + 35621 + ], + "area": 484856.48801000003, + "iscrowd": 0, + "segmentation": [], + "text": "Experimental paradigm" + }, + { + "id": 35610, + "strid": "9cf01d41-8a37-4e08-93a8-d03f770f942b", + "image_id": 201905, + "image_name": "117856.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 106.649, + 1432.312, + 1004.0860000000001, + 439.7180000000001 + ], + "priority": 6, + "parents": [ + 35606 + ], + "children": [], + "area": 152754.64248799998, + "iscrowd": 0, + "segmentation": [], + "text": "We measured neural responses to unattended observed actions\nwith fMRI. Participants (n = 17) performed an attentionally\ndemanding visual task while video clips of object-directed hand\nactions were presented at fixation. Consecutive presentations of\neither repeated or novel agents, goals, or kinematics in the hand\naction videos were used to measure neural activation to novel\nversus repeated actions (repetition supression) while those actions\n\nwere unattended." + }, + { + "id": 35621, + "strid": "954137de-455f-4f6e-a39a-9d3abcb58d4e", + "image_id": 201905, + "image_name": "117856.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 113.865, + 1928.906, + 992.336, + 939.4580000000001 + ], + "priority": 7, + "parents": [ + 35606 + ], + "children": [ + 35619 + ], + "area": 219634.88168999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 35619, + "strid": "2cb72fec-e478-48ec-8b97-9830534ffea8", + "image_id": 201905, + "image_name": "117856.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 109.616, + 2916.759, + 1013.348, + 232.08600000000024 + ], + "priority": 8, + "parents": [ + 35621 + ], + "children": [], + "area": 319723.454544, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. Time sequence of one block of the experiment. After the target\ninstruction, 12-16 videos were presented in a pseudo-random order, followed by\na response screen and rest. Video clips depicted simple object-directed actions\nwhere objects (books or pencilcases) were opened or closed by either a female\nor a male actor. The movements were also manipulated to be slow or fast.\nParticipants were asked to count the number of targets throughout a block while\nneural activity related to novel or repeated action properties was measured." + }, + { + "id": 35611, + "strid": "6258ff50-cf66-4792-b70b-64db83d24aa3", + "image_id": 201905, + "image_name": "117856.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1290.977, + 571.827, + 1005.1200000000001, + 205.02099999999996 + ], + "priority": 9, + "parents": [ + 35606 + ], + "children": [], + "area": 738215.5049790001, + "iscrowd": 0, + "segmentation": [], + "text": "To investigate the effect of attention, participants were asked to\nmonitor for target stimuli in two rapidly changing visual streams, to\nthe left and right of the action videos, under conditions of high and\nlow attentional load." + }, + { + "id": 35626, + "strid": "658c51f7-51bb-42f0-a6b4-5ab02269afe7", + "image_id": 201905, + "image_name": "117856.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1285.939, + 807.596, + 975.4199999999998, + 483.961 + ], + "priority": 10, + "parents": [ + 35606 + ], + "children": [ + 35615 + ], + "area": 1038519.192644, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 35615, + "strid": "016d81af-ae43-4d5e-8444-a1f316e9013f", + "image_id": 201905, + "image_name": "117856.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1333.675, + 1346.122, + 885.481, + 99.31799999999998 + ], + "priority": 11, + "parents": [ + 35626 + ], + "children": [], + "area": 1795289.25835, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2. High and low-load attentional task. (a) Illustration of the stimuli\npositions with the action videos and the attentional task. (6) Example\nstimuli depicting “low-load” and “high-load” conditions." + }, + { + "id": 35607, + "strid": "72ac8e70-0938-4ed7-8e54-1d821e8d647f", + "image_id": 201905, + "image_name": "117856.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1717.624, + 1521.111, + 164.34699999999998, + 46.85200000000009 + ], + "priority": 12, + "parents": [ + 35627 + ], + "children": [ + 35622, + 35612, + 35613, + 35624, + 35623, + 35625, + 35614 + ], + "area": 2612696.7602640004, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 35612, + "strid": "06c91e1e-8c22-409e-a171-b22afd09e165", + "image_id": 201905, + "image_name": "117856.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1286.83, + 1627.151, + 1018.9079999999999, + 444.05799999999977 + ], + "priority": 13, + "parents": [ + 35607 + ], + "children": [], + "area": 2093866.7213299999, + "iscrowd": 0, + "segmentation": [], + "text": "Regardless of different action representations or attentional\nconditions large repetition suppression effects were found in the\nventral and dorsal parietal cortex, bilaterally in the premotor areas,\nin the supplementary motor area and in the inferior frontal cortex.\nThese areas are traditionally considered part of the action\nobservation network (Figure 3). No significant attenuation in the\nneuronal response was found uniquely linked to agency, kinematics\n\nor goals." + }, + { + "id": 35622, + "strid": "2a9a77ae-7f9b-4e76-832c-286b9210f87c", + "image_id": 201905, + "image_name": "117856.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1304.478, + 2068.175, + 988.6239999999998, + 408.73199999999997 + ], + "priority": 14, + "parents": [ + 35607 + ], + "children": [ + 35618 + ], + "area": 2697888.7876500003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 35618, + "strid": "87432b0e-07d9-4b97-8a7f-e54cc35db957", + "image_id": 201905, + "image_name": "117856.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1316.511, + 2527.239, + 888.8250000000003, + 99.0010000000002 + ], + "priority": 15, + "parents": [ + 35622 + ], + "children": [], + "area": 3327137.943129, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3. Brain areas showing more activation for novel versus repeated\naction properties across low and high attentional conditions and action\nrepresentations." + }, + { + "id": 35614, + "strid": "630abd11-db6d-4672-9dda-2f7e9da7d260", + "image_id": 201905, + "image_name": "117856.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1291.381, + 2703.217, + 999.2250000000001, + 447.0250000000001 + ], + "priority": 16, + "parents": [ + 35607 + ], + "children": [], + "area": 3490883.0726770004, + "iscrowd": 0, + "segmentation": [], + "text": "Increased repetition suppression was found under high versus low\nattentional load in the right superior frontal, left preceniral and left\ninferior frontal regions of the brain (Figure 4). To further investigate\nthis neural pattern we collected mean parameter estimates from\nthese areas. Interestingly, the enhanced neural attenuation under\nhigh-load was the result of two factors: stronger neural attenuation\nfor repeated and enhanced neural response for novel action\n\nproperties under high-load compared to low-load (Figure 4 (b))." + }, + { + "id": 35624, + "strid": "c35a8e00-4cc1-42f7-bf07-60b29271f949", + "image_id": 201905, + "image_name": "117856.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2465.884, + 546.398, + 375.35599999999977, + 733.728 + ], + "priority": 17, + "parents": [ + 35607 + ], + "children": [ + 35616 + ], + "area": 1347354.085832, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 35616, + "strid": "b5b22908-42dc-4b66-8230-eefbe860335c", + "image_id": 201905, + "image_name": "117856.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2855.013, + 1121.084, + 656.355, + 199.442 + ], + "priority": 18, + "parents": [ + 35624 + ], + "children": [], + "area": 3200709.394092, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 4. (a) Brain areas showing stronger repetition\nsuppression during high attentional load compared\nto low-load. (b) Mean parameter estimates\naveraged for right superior parietal (82 -50 52), left\nprecentral (-32 -2 48), and left inferior frontal (-34 16\n24) regions with standard error bars." + }, + { + "id": 35625, + "strid": "771ea20a-1685-46a7-bc0a-63677213ae3f", + "image_id": 201905, + "image_name": "117856.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2882.544, + 545.013, + 544.9520000000002, + 507.235 + ], + "priority": 19, + "parents": [ + 35607 + ], + "children": [], + "area": 1571023.953072, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 35613, + "strid": "e780b5e7-3069-4859-a778-71205560811b", + "image_id": 201905, + "image_name": "117856.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2468.022, + 1390.176, + 1022.0610000000001, + 331.27300000000014 + ], + "priority": 20, + "parents": [ + 35607 + ], + "children": [], + "area": 3430984.9518719995, + "iscrowd": 0, + "segmentation": [], + "text": "On a whole brain level novel actions elicited greater neural\nresponses under high-load compared to low-load in the premotor\ncortex bilaterally extending to the inferior frontal gyrus pars\nopercularis and pars triangularis, and bilateral regions of the inferior\nparietal cortex extending towards the superior parietal lobe and\n\npostcentral gyrus (Figure 5)." + }, + { + "id": 35623, + "strid": "0b639d09-03a4-4978-b4be-47b17bfac475", + "image_id": 201905, + "image_name": "117856.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2520.967, + 1760.484, + 904.8710000000001, + 592.2419999999997 + ], + "priority": 21, + "parents": [ + 35607 + ], + "children": [ + 35617 + ], + "area": 4438122.068028, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 35617, + "strid": "fd6af591-c171-411b-8ace-e366615caa31", + "image_id": 201905, + "image_name": "117856.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2470.021, + 2399.467, + 952.482, + 64.77500000000009 + ], + "priority": 22, + "parents": [ + 35623 + ], + "children": [], + "area": 5926733.878807001, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 5. Brain areas showing significantly greater activation for novel actions\nduring high attentional load compared with low-load." + }, + { + "id": 35608, + "strid": "a429dce9-17df-4bad-a3d1-bb453473dc1a", + "image_id": 201905, + "image_name": "117856.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2825.64, + 2524.774, + 272.56399999999985, + 49.125 + ], + "priority": 23, + "parents": [ + 35627 + ], + "children": [ + 35620 + ], + "area": 7134102.405359999, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 35620, + "strid": "1231647c-0207-4187-92b2-ca30c9b24161", + "image_id": 201905, + "image_name": "117856.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2467.697, + 2623.438, + 1016.355, + 532.739 + ], + "priority": 24, + "parents": [ + 35608 + ], + "children": [], + "area": 6473850.082286, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 31753, + "strid": "6e2e7440-f1d6-4544-b058-197f6672f066", + "image_id": 201745, + "image_name": "117615.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 309.38, + 552.07, + 310.47, + 294.94999999999993 + ], + "priority": -1, + "parents": [], + "children": [ + 31729, + 31737, + 31733, + 31739, + 31748, + 31740, + 31734, + 31747, + 31738, + 31730, + 31750, + 31745, + 31749 + ], + "area": 170799.41660000003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 31729, + "strid": "be3d9c23-6d43-49c0-a1b3-f32e527c00f1", + "image_id": 201745, + "image_name": "117615.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 578.004, + 90.878, + 2623.125, + 219.212 + ], + "priority": 1, + "parents": [ + 31753 + ], + "children": [], + "area": 52527.847512, + "iscrowd": 0, + "segmentation": [], + "text": "vGWAS Revisited: A Novel and Powerful Approach to\nVoxelwise Genome-Wide Association Studies" + }, + { + "id": 31730, + "strid": "aacfe56c-3cc4-4e78-8b8d-881cf8a93857", + "image_id": 201745, + "image_name": "117615.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 704.795, + 401.546, + 2346.679, + 455.20200000000006 + ], + "priority": 2, + "parents": [ + 31753 + ], + "children": [], + "area": 283007.61306999996, + "iscrowd": 0, + "segmentation": [], + "text": "Jonathan D. Rosenblatt[1], Jason L. Stein[2,3], Marina Bogomolov[4],\nPaul Thompson[3], Yoav Benjamini[1,5]\n\n[1]Dept. of Statistics and Operations Research, Raymond and Beverly Sackler Faculty of Exact Sciences. Tel Aviv University\n[2]Program in Neurogenetics, Department of Neurology and Center for Autism Research and Treatment, UCLA\n[3]Imaging Genetics Center, Laboratory of Neuro Imaging, UCLA\n[4]Faculty of Industrial Engineering and Management, Technion Institute of Technology\n{5]The Sagol School of Neurosciences, Tel Aviv University" + }, + { + "id": 31733, + "strid": "97b7d16f-73cc-4c8b-8082-a9daf38c17e7", + "image_id": 201745, + "image_name": "117615.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 116.863, + 1013.826, + 299.41, + 69.28500000000008 + ], + "priority": 3, + "parents": [ + 31753 + ], + "children": [ + 31731 + ], + "area": 118478.747838, + "iscrowd": 0, + "segmentation": [], + "text": "Motivation" + }, + { + "id": 31731, + "strid": "9a3508be-f93a-43ff-80cb-a68b79f28764", + "image_id": 201745, + "image_name": "117615.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 111.915, + 1115.279, + 1986.991, + 168.26299999999992 + ], + "priority": 4, + "parents": [ + 31733 + ], + "children": [], + "area": 124816.44928500001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 31738, + "strid": "e71f39de-8e3f-49fe-b102-e943b7ce3b72", + "image_id": 201745, + "image_name": "117615.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 121.105, + 1322.073, + 259.818, + 72.4659999999999 + ], + "priority": 5, + "parents": [ + 31753 + ], + "children": [ + 31732 + ], + "area": 160109.65066500002, + "iscrowd": 0, + "segmentation": [], + "text": "Challenge" + }, + { + "id": 31732, + "strid": "65e77bd6-d022-4a9d-afee-aa5efc95e521", + "image_id": 201745, + "image_name": "117615.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 111.915, + 1424.586, + 1279.296, + 66.80999999999995 + ], + "priority": 6, + "parents": [ + 31738 + ], + "children": [], + "area": 159432.54219, + "iscrowd": 0, + "segmentation": [], + "text": "Massive multiple testing problem: 14x10? hypotheses." + }, + { + "id": 31739, + "strid": "e8a1e485-83af-4afa-8b76-edb2913cfabe", + "image_id": 201745, + "image_name": "117615.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 114.035, + 1583.659, + 136.095, + 58.327 + ], + "priority": 7, + "parents": [ + 31753 + ], + "children": [ + 31741 + ], + "area": 180592.554065, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 31741, + "strid": "9582511d-f202-4398-bf7e-534771fe8c73", + "image_id": 201745, + "image_name": "117615.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 108.388, + 1674.217, + 1242.44, + 247.98700000000008 + ], + "priority": 8, + "parents": [ + 31739 + ], + "children": [], + "area": 181465.03219600001, + "iscrowd": 0, + "segmentation": [], + "text": "ADNI data [2] as used in Stein et. al [1]: N=740.\nSNPs=448,293 after quality control.\n\nVoxels=31,622 after down-sampling (4x4x4mm3).\n14,175,921,246 SNP-to-voxel candidate associations." + }, + { + "id": 31737, + "strid": "78d9bc91-9b50-497a-bd4a-6ce0271988d5", + "image_id": 201745, + "image_name": "117615.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1561.594, + 1502.355, + 772.3850000000002, + 470.14699999999993 + ], + "priority": 9, + "parents": [ + 31753 + ], + "children": [ + 31736 + ], + "area": 2346068.55387, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 31736, + "strid": "2008405b-3b72-4b8a-b3aa-0c0b57f55ec7", + "image_id": 201745, + "image_name": "117615.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1549.222, + 1394.54, + 782.99, + 88.37400000000002 + ], + "priority": 10, + "parents": [ + 31737 + ], + "children": [], + "area": 2160452.04788, + "iscrowd": 0, + "segmentation": [], + "text": "able 1- Rejected Voxel Count. SNP selected at\nIFDR of 0.05 and voxel selected at within-SNP" + }, + { + "id": 31734, + "strid": "aa1101ed-aadd-4644-a666-2573bef40378", + "image_id": 201745, + "image_name": "117615.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2491.284, + 1132.954, + 662.8020000000001, + 841.316 + ], + "priority": 11, + "parents": [ + 31753 + ], + "children": [ + 31735 + ], + "area": 2822510.172936, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 31735, + "strid": "e10e0854-c06a-4d82-9ce3-39a424a16a80", + "image_id": 201745, + "image_name": "117615.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2500.122, + 1026.906, + 625.685, + 81.30400000000009 + ], + "priority": 12, + "parents": [ + 31734 + ], + "children": [], + "area": 2567390.2825319995, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1-Significant associations with\nSNP rs11872654." + }, + { + "id": 31740, + "strid": "259afcbc-3ac0-467d-bb8d-b634d5079c3c", + "image_id": 201745, + "image_name": "117615.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 121.105, + 1970.735, + 206.79399999999998, + 53.024000000000115 + ], + "priority": 13, + "parents": [ + 31753 + ], + "children": [ + 31742 + ], + "area": 238665.862175, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 31742, + "strid": "d993b00d-e6b1-4efd-99c4-fe54937ad021", + "image_id": 201745, + "image_name": "117615.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 113.398, + 2052.46, + 3078.546, + 323.1350000000002 + ], + "priority": 14, + "parents": [ + 31740 + ], + "children": [], + "area": 232744.85908, + "iscrowd": 0, + "segmentation": [], + "text": "<1> Compute all SNP-to-voxel associations using a 2DF allele effect. <2> Infer on associated SNPs by aggregating p-vaules over all\nvoxels (for each SNP) using Sime's procedure [4]: pvalsnp=min{pvalsnp(i) m/i} where m is the number of SNPs and (i) the i'th\nsmallest p-value within the SNP <3> Select associated SNPs with FDR control (on SNPs), using B-H [5] procedure on aggregated\npvalues. <4> Localize associations by using conservative B-H on SNP-to-voxel p-values. Deflate error rate to\n\nq x #{selected SNPs}/#{considered SNPs} to guarantee *average* FDR, over selected SNPs, is smaller than q [proof in ref. 3]." + }, + { + "id": 31748, + "strid": "42dc35a7-91e9-4f51-808d-b66bdb2a020b", + "image_id": 201745, + "image_name": "117615.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 115.903, + 2413.168, + 202.899, + 62.62300000000005 + ], + "priority": 15, + "parents": [ + 31753 + ], + "children": [ + 31743 + ], + "area": 279693.41070400004, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 31743, + "strid": "351a88c3-f5fd-4e09-82be-b4a4672c2a22", + "image_id": 201745, + "image_name": "117615.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 108.388, + 2505.85, + 1683.306, + 335.6590000000001 + ], + "priority": 16, + "parents": [ + 31748 + ], + "children": [], + "area": 271604.0698, + "iscrowd": 0, + "segmentation": [], + "text": "We find 11 significantly associated SNPs (SNP-FDR=0.05). Drilling into these\nSNPs, we find 349 significantly associated voxels (Average SNP-wise FDR=0.05).\nTable 1: Distribution of number of associated voxels over discovered SNPs.\nFigure 1: Localization of associations with the most associated SNP\n\nFigure 2: The distribution of the raw phenotype (registration's Jakobians) at the\nlocations most associated with each selected SNP" + }, + { + "id": 31747, + "strid": "ae6f780f-8807-4790-864a-9b415a9860d1", + "image_id": 201745, + "image_name": "117615.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 115.903, + 2879.083, + 288.066, + 62.62300000000005 + ], + "priority": 17, + "parents": [ + 31753 + ], + "children": [ + 31746 + ], + "area": 333694.35694900004, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion" + }, + { + "id": 31746, + "strid": "eb0b08a6-dfce-4c9a-86ec-3cb9a827e482", + "image_id": 201745, + "image_name": "117615.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 110.893, + 2966.755, + 1991.411, + 388.26200000000017 + ], + "priority": 18, + "parents": [ + 31747 + ], + "children": [], + "area": 328992.36221500003, + "iscrowd": 0, + "segmentation": [], + "text": "Using N=740 subjects alone, we are able to detect 11 significantly associated SNPs, and 349\nvoxels therein. This serves as an important proof of concept of the power in the hierarchical\napproach. We currently refrain from discussing the biological implications of the findings, as\nwe are currently in the process of replicating them. We do note however, that associations were\nlocalized to the ventrices. This finding could be interpreted as due to the relative spatial\nflexibility at ventricle boundaries. The direction of causality is left an open question, as\n\nbrain diseases, such as Alzheimer's, are often associated to tissue loss near the ventrices." + }, + { + "id": 31745, + "strid": "d94d9f46-5609-4f25-9713-d7f464ee19d8", + "image_id": 201745, + "image_name": "117615.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2144.888, + 2658.65, + 914.2960000000003, + 723.922 + ], + "priority": 19, + "parents": [ + 31753 + ], + "children": [ + 31744 + ], + "area": 5702506.4812, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 31744, + "strid": "294449f1-effd-433b-9b53-6ad0fc7e5649", + "image_id": 201745, + "image_name": "117615.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2149.898, + 2458.257, + 1027.0169999999998, + 185.36400000000003 + ], + "priority": 20, + "parents": [ + 31745 + ], + "children": [], + "area": 5285001.807786001, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2- Distribution of Jakobians vs. Genotype at\nsignificant Locations. One for each SNP Group size on the x-\naxis. From homozygous minor allele (leftmost) to\nhomozygous major allele (rightmost)." + }, + { + "id": 31749, + "strid": "a04fffc6-1139-431b-bb4d-6981162bc45f", + "image_id": 201745, + "image_name": "117615.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 88.349, + 3425.155, + 423.331, + 75.14800000000014 + ], + "priority": 21, + "parents": [ + 31753 + ], + "children": [ + 31751 + ], + "area": 302609.01909500005, + "iscrowd": 0, + "segmentation": [], + "text": "\"Take Home\"" + }, + { + "id": 31751, + "strid": "f117a820-8bc5-4983-a078-31956a5c5409", + "image_id": 201745, + "image_name": "117615.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 88.349, + 3535.372, + 3081.051, + 210.413 + ], + "priority": 22, + "parents": [ + 31749 + ], + "children": [], + "area": 312346.580828, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 31750, + "strid": "6688764d-3106-4bdd-9828-c5de3460df13", + "image_id": 201745, + "image_name": "117615.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 93.359, + 3881.051, + 217.928, + 47.59299999999985 + ], + "priority": 23, + "parents": [ + 31753 + ], + "children": [ + 31752 + ], + "area": 362331.04030899995, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 31752, + "strid": "a527fd5d-4608-4456-9548-08f322c12a38", + "image_id": 201745, + "image_name": "117615.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 83.339, + 3961.208, + 3033.457, + 435.8560000000002 + ], + "priority": 24, + "parents": [ + 31750 + ], + "children": [], + "area": 330123.113512, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 198044, + "strid": "58f5765b-2a59-4785-a36a-72e6b709450d", + "image_id": 208259, + "image_name": "9785.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 171.51, + 111.77, + 260.64, + 254.84000000000003 + ], + "priority": -1, + "parents": [], + "children": [ + 198026, + 198023, + 198022, + 198030, + 198024, + 198029, + 198027, + 198028, + 198031, + 198025 + ], + "area": 19169.6727, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 198022, + "strid": "e62d3783-f5dd-4cde-8200-f19829db7681", + "image_id": 208259, + "image_name": "9785.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 538.044, + 55.669, + 3377.048, + 294.787 + ], + "priority": 1, + "parents": [ + 198044 + ], + "children": [], + "area": 29952.371435999998, + "iscrowd": 0, + "segmentation": [], + "text": "Predicting non-coding variant impact on the human brain:\na machine learning approach" + }, + { + "id": 198023, + "strid": "05e52910-ee48-4403-8342-6f104d9d7f01", + "image_id": 208259, + "image_name": "9785.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1204.653, + 414.706, + 2014.405, + 208.514 + ], + "priority": 2, + "parents": [ + 198044 + ], + "children": [], + "area": 499576.827018, + "iscrowd": 0, + "segmentation": [], + "text": "Kévin Vervier ', Abdollah Dehzangi', Jacob Michaelson!\n' Department of Psychiatry, University of lowa, IA, USA\n* contact: kevin-vervier@uiowa.edu" + }, + { + "id": 198024, + "strid": "3671a0c0-3ae9-4be0-86c1-781c6fc289f2", + "image_id": 208259, + "image_name": "9785.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 121.597, + 786.635, + 268.772, + 52.559999999999945 + ], + "priority": 3, + "parents": [ + 198044 + ], + "children": [ + 198040 + ], + "area": 95652.456095, + "iscrowd": 0, + "segmentation": [], + "text": "Overview" + }, + { + "id": 198040, + "strid": "3ba99cd7-ef02-4bbf-93ea-84c14e6a31cd", + "image_id": 208259, + "image_name": "9785.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 37.924, + 858.399, + 1545.092, + 515.6629999999999 + ], + "priority": 4, + "parents": [ + 198024 + ], + "children": [], + "area": 32553.923676, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 198025, + "strid": "7f461ed0-cdae-424c-b7f9-1bd596ab4e36", + "image_id": 208259, + "image_name": "9785.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 108.851, + 1490.845, + 422.448, + 57.412000000000035 + ], + "priority": 5, + "parents": [ + 198044 + ], + "children": [ + 198032 + ], + "area": 162279.969095, + "iscrowd": 0, + "segmentation": [], + "text": "1. Introduction" + }, + { + "id": 198032, + "strid": "2aa5dd80-ff4a-4648-acb3-9b92dcd4edaa", + "image_id": 208259, + "image_name": "9785.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 141.545, + 1608.31, + 1289.961, + 655.9919999999997 + ], + "priority": 6, + "parents": [ + 198025 + ], + "children": [], + "area": 227648.23894999997, + "iscrowd": 0, + "segmentation": [], + "text": "Recent studies show evidence that non-coding variants\nmay play an important role in disease understanding.\nOne of the main challenges in annotation is to prioritize\nthe variants and select candidates for further studies.\nHowever, current annotation tools, like CADD [1], provide\na general framework and do not use tissue-related\ninformation to achieve higher sensitivity in variant\nprioritization. In this work, we propose a new machine-\nlearning based approach, the Brain Relevance Score\n(BRS) relying on tissue-specific data to estimate variant\nimpact in brain tissues." + }, + { + "id": 198026, + "strid": "118e201e-5371-4802-b8f9-cbd872deba84", + "image_id": 208259, + "image_name": "9785.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 110.323, + 2391.079, + 693.363, + 59.01000000000022 + ], + "priority": 7, + "parents": [ + 198044 + ], + "children": [ + 198038, + 198033 + ], + "area": 263791.008517, + "iscrowd": 0, + "segmentation": [], + "text": "2. Material and Methods" + }, + { + "id": 198038, + "strid": "8d675406-126c-4424-a89a-95688b7ffd4b", + "image_id": 208259, + "image_name": "9785.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 138.673, + 2537.158, + 1266.245, + 673.482 + ], + "priority": 8, + "parents": [ + 198026 + ], + "children": [], + "area": 351835.31133399997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 198033, + "strid": "0b69b84f-06ce-46e2-bc41-479789c6ffe7", + "image_id": 208259, + "image_name": "9785.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 132.46, + 3244.311, + 1276.59, + 237.76299999999992 + ], + "priority": 9, + "parents": [ + 198026 + ], + "children": [], + "area": 429741.43506000005, + "iscrowd": 0, + "segmentation": [], + "text": "we trained a predictive model on ~35,000 brain/non-brain\npositions from DisGeNET [5] and lincSNP [6] databases.\nThis model is able to estimate how related to the brain\na genomic position is." + }, + { + "id": 198027, + "strid": "9a10bc92-2e92-496d-aeb1-e1a42850879c", + "image_id": 208259, + "image_name": "9785.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1634.795, + 783.173, + 765.694, + 52.97199999999998 + ], + "priority": 10, + "parents": [ + 198044 + ], + "children": [ + 198041, + 198034 + ], + "area": 1280327.3045350001, + "iscrowd": 0, + "segmentation": [], + "text": "3. Cross-validation results" + }, + { + "id": 198034, + "strid": "8aaff544-a9e4-4ba3-b7ff-9798ca3377a5", + "image_id": 208259, + "image_name": "9785.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1669.609, + 927.516, + 1240.5970000000002, + 233.04000000000008 + ], + "priority": 11, + "parents": [ + 198027 + ], + "children": [], + "area": 1548589.061244, + "iscrowd": 0, + "segmentation": [], + "text": "We used Random Forest to train a predictive model,\nusing 10-folds cross-validation for parameter\noptimization and reported AUC = 0.78. Using rescaled\nodd-ratios obtained from the model, we define BRS as:" + }, + { + "id": 198041, + "strid": "a884f63a-dbe3-40f2-ba99-7950423cf6dc", + "image_id": 208259, + "image_name": "9785.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1632.152, + 1207.143, + 1335.5820000000003, + 718.9169999999999 + ], + "priority": 12, + "parents": [ + 198027 + ], + "children": [], + "area": 1970240.861736, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 198028, + "strid": "bdf8eb68-fce2-4b16-a302-d2645df1bf65", + "image_id": 208259, + "image_name": "9785.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1634.269, + 2057.633, + 860.8570000000002, + 65.63500000000022 + ], + "priority": 13, + "parents": [ + 198044 + ], + "children": [ + 198035, + 198043 + ], + "area": 3362725.8252769997, + "iscrowd": 0, + "segmentation": [], + "text": "4. Case study: 16p11.2 region" + }, + { + "id": 198035, + "strid": "c4975224-12f7-46a5-ba5c-5edccd47b003", + "image_id": 208259, + "image_name": "9785.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1654.103, + 2206.259, + 1293.107, + 479.8029999999999 + ], + "priority": 14, + "parents": [ + 198028 + ], + "children": [], + "area": 3649379.630677, + "iscrowd": 0, + "segmentation": [], + "text": "Mutations in 16p11.2 region have been associated with\nmental conditions. Here, we propose to compare CADD\n(blue) with the score filtered by BRS (purple), on the\nwhole region (left) and on a selected peak (right). Overall,\nthe filtered signal is sparser and ease the selection of\ncandidate variants related to the human brain. For\ninstance, the gold peak is located close to TUFM gene\neQTLs associated with fatal encephalopathy." + }, + { + "id": 198043, + "strid": "e73cee20-4f06-4ef3-9464-b7ece1e72369", + "image_id": 208259, + "image_name": "9785.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1654.324, + 2712.046, + 1289.6730000000002, + 773.4200000000001 + ], + "priority": 15, + "parents": [ + 198028 + ], + "children": [], + "area": 4486602.786904, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 198029, + "strid": "8740f98b-96e2-44bc-8002-c6a3b7ed228c", + "image_id": 208259, + "image_name": "9785.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3173.494, + 784.625, + 1184.337, + 68.543 + ], + "priority": 16, + "parents": [ + 198044 + ], + "children": [ + 198036, + 198042 + ], + "area": 2490002.72975, + "iscrowd": 0, + "segmentation": [], + "text": "5. BRS enrichment in ASD genes vicinity" + }, + { + "id": 198036, + "strid": "0c6ae7be-9475-4683-8b9e-e760b8aa8c5c", + "image_id": 208259, + "image_name": "9785.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3189.205, + 924.491, + 1299.9899999999998, + 356.9169999999999 + ], + "priority": 17, + "parents": [ + 198029 + ], + "children": [], + "area": 2948391.3196549998, + "iscrowd": 0, + "segmentation": [], + "text": "We evaluate BRS enrichment for variants close to ASD-\nrelated genes (1Mbp), found in Simons Simplex\nCollection (SSC, [7]) and 1000Genomes (1KG). Results\nshow enrichment for coding and non-coding SNVs,\nsuggesting higher genetic burden in SSC cohort on\naverage, but also in the top hits." + }, + { + "id": 198042, + "strid": "8090f626-bd79-4973-b651-ff6c62f9db28", + "image_id": 208259, + "image_name": "9785.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3160.372, + 1311.103, + 1332.9119999999998, + 614.7 + ], + "priority": 18, + "parents": [ + 198029 + ], + "children": [], + "area": 4143573.210316, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 198030, + "strid": "b897935f-2c45-4abd-b240-32111c4c24c3", + "image_id": 208259, + "image_name": "9785.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3174.473, + 2061.227, + 391.8890000000001, + 51.1869999999999 + ], + "priority": 19, + "parents": [ + 198044 + ], + "children": [ + 198037 + ], + "area": 6543309.458370999, + "iscrowd": 0, + "segmentation": [], + "text": "6. Discussion" + }, + { + "id": 198037, + "strid": "bb1d6570-45c1-4e46-b7c6-afec4e1cc6d0", + "image_id": 208259, + "image_name": "9785.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3188.646, + 2205.39, + 1301.7950000000005, + 484.0430000000001 + ], + "priority": 20, + "parents": [ + 198030 + ], + "children": [], + "area": 7032208.00194, + "iscrowd": 0, + "segmentation": [], + "text": "In this study, we address the problem of predicting brain\nrelevance for any genome position. We present BRS, a\nnovel tool that can be used as a mask on existing\nvariant annotation scores, like CADD. This way, it\nimproves variant prioritization, based on human brain\ntissues.\n\nThe learning framework we develop could be easily\nadapted for any other tissue than human brain." + }, + { + "id": 198031, + "strid": "f8a9e594-3f8d-446c-85a7-d765c83aa59e", + "image_id": 208259, + "image_name": "9785.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3190.416, + 2784.622, + 924.1589999999997, + 67.41499999999996 + ], + "priority": 21, + "parents": [ + 198044 + ], + "children": [ + 198039 + ], + "area": 8884102.582752, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgments - References" + }, + { + "id": 198039, + "strid": "dc5d9408-387a-4c36-8ea9-f65509fe5e0e", + "image_id": 208259, + "image_name": "9785.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3190.609, + 2917.367, + 1059.2279999999996, + 596.623 + ], + "priority": 22, + "parents": [ + 198031 + ], + "children": [], + "area": 9308177.406503001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 111275, + "strid": "a6d08b4c-afad-4871-92b6-4e472fa46072", + "image_id": 204818, + "image_name": "13194.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 1299.34, + 633.78, + 684.5800000000002, + 138.54000000000008 + ], + "priority": -1, + "parents": [], + "children": [ + 111256, + 111258, + 111255, + 111260, + 111261, + 111262, + 111257, + 111259 + ], + "area": 823495.7052, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 111255, + "strid": "ba3032c4-36be-4972-bcb4-c8702fb1598d", + "image_id": 204818, + "image_name": "13194.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 137.712, + 126.564, + 3232.96, + 140.57699999999997 + ], + "priority": 1, + "parents": [ + 111275 + ], + "children": [], + "area": 17429.381567999997, + "iscrowd": 0, + "segmentation": [], + "text": "Vertebral labeling on MRI using deep learning techniques" + }, + { + "id": 111256, + "strid": "b7519213-5037-4cb7-a6a4-226c72a648ea", + "image_id": 204818, + "image_name": "13194.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 566.993, + 292.781, + 2393.579, + 251.329 + ], + "priority": 2, + "parents": [ + 111275 + ], + "children": [], + "area": 166004.77753300001, + "iscrowd": 0, + "segmentation": [], + "text": "Francisco Perdigon Romero!, Jean-Pierre David', Julien Cohen-Adad'”\n\n' Department of Electrical Engineering, Polytechnique de Montréal, Montréal, QC, Canada\nYpolymtl.ca 7” Functional Neuroimaging Unit, CRIUGM, Université de Montréal, Montreal, QC, Canada" + }, + { + "id": 111257, + "strid": "1079973d-67f9-4e1c-896c-dbcf4631d5b5", + "image_id": 204818, + "image_name": "13194.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 99.835, + 670.29, + 702.375, + 109.47500000000002 + ], + "priority": 3, + "parents": [ + 111275 + ], + "children": [ + 111263 + ], + "area": 66918.40215, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 111263, + "strid": "b338095b-5db3-44e5-9b97-86026fc0ca87", + "image_id": 204818, + "image_name": "13194.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 99.642, + 857.029, + 2062.532, + 373.8890000000001 + ], + "priority": 4, + "parents": [ + 111257 + ], + "children": [], + "area": 85396.08361799999, + "iscrowd": 0, + "segmentation": [], + "text": "For the diagnosis and monitoring of various diseases in the spine and the central nervous\nsystem, the detection and labeling of vertebrae in magnetic resonance imaging (MRI) is\nuseful. Although several automatic methods for the detection and labeling of vertebrae have\nbeen developed (Lootus et al, 2014; Ullmann et al, 2014) this is still an open problem in\nwhich many improvements can be made." + }, + { + "id": 111258, + "strid": "e0d81274-520a-4770-82e4-3080114b42b4", + "image_id": 204818, + "image_name": "13194.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2327.926, + 666.196, + 532.7649999999999, + 119.42899999999997 + ], + "priority": 5, + "parents": [ + 111275 + ], + "children": [ + 111264 + ], + "area": 1550854.989496, + "iscrowd": 0, + "segmentation": [], + "text": "Materials" + }, + { + "id": 111264, + "strid": "c47f842b-8947-4208-9eaa-d85dbfb578bb", + "image_id": 204818, + "image_name": "13194.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2327.907, + 860.722, + 1026.2820000000002, + 371.71000000000004 + ], + "priority": 6, + "parents": [ + 111258 + ], + "children": [], + "area": 2003680.7688540001, + "iscrowd": 0, + "segmentation": [], + "text": "Dataset: 631 mid sagittal slices\n\nMRI modality: T2\n\nSpatial resolution: 1mm x Imm.\nTrain/Validation/Test: 60/20/20\n\nDeep Learning framework: Keras/Tensorflow" + }, + { + "id": 111259, + "strid": "683f1602-74c7-4f98-b89c-e02567760395", + "image_id": 204818, + "image_name": "13194.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 100.139, + 1376.984, + 494.751, + 110.83699999999999 + ], + "priority": 7, + "parents": [ + 111275 + ], + "children": [ + 111273, + 111265, + 111270, + 111272, + 111269, + 111274 + ], + "area": 137889.800776, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 111274, + "strid": "afe11b04-e743-4e26-af42-4139d95a489d", + "image_id": 204818, + "image_name": "13194.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 170.312, + 1560.951, + 877.11, + 866.5929999999998 + ], + "priority": 8, + "parents": [ + 111259 + ], + "children": [], + "area": 265848.686712, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 111270, + "strid": "02287b7b-c018-40db-93ee-7d065afdafa3", + "image_id": 204818, + "image_name": "13194.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1102.189, + 1453.22, + 1356.204, + 1056.2169999999999 + ], + "priority": 9, + "parents": [ + 111259 + ], + "children": [], + "area": 1601723.0985800002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 111272, + "strid": "1ea32e7e-57d2-446c-a242-006720b99c7e", + "image_id": 204818, + "image_name": "13194.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2490.896, + 1529.284, + 866.6129999999998, + 892.3339999999998 + ], + "priority": 10, + "parents": [ + 111259 + ], + "children": [], + "area": 3809287.3984640003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 111273, + "strid": "dbd1ad92-79c3-484c-a268-9edce9527c59", + "image_id": 204818, + "image_name": "13194.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 193.604, + 2547.861, + 1452.68, + 87.86200000000008 + ], + "priority": 11, + "parents": [ + 111259 + ], + "children": [], + "area": 493276.081044, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 111265, + "strid": "3fba5010-9a28-483f-93c8-a5ddbb23c842", + "image_id": 204818, + "image_name": "13194.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 118.818, + 2732.955, + 2318.424, + 439.19500000000016 + ], + "priority": 12, + "parents": [ + 111259 + ], + "children": [], + "area": 324724.24718999997, + "iscrowd": 0, + "segmentation": [], + "text": "One way to detect the vertebra is to focus on the intervertebral discs (IVD), which are natural spacers\nbetween vertebrae. In this work we present a set of convolutional networks (CNN) that perform\nregression for the detection and labeling of the first 6 [VDs (C2-C3 to C7-T1) using. The entry for\neach of the CNNs is the midsagittal plane image of the acquired volume. Each CNN is in charge of\ndetecting one IVD, so the labeling is done implicitly. The output of each CNN is the coordinate (x, y)\nof the located IVD." + }, + { + "id": 111269, + "strid": "28be9d4c-5f3f-4357-a927-1af745ec6666", + "image_id": 204818, + "image_name": "13194.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2495.933, + 2483.706, + 865.5259999999998, + 766.7350000000001 + ], + "priority": 13, + "parents": [ + 111259 + ], + "children": [], + "area": 6199163.767698, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 111260, + "strid": "02aa874a-96b2-4671-9efb-4a01e0a4527b", + "image_id": 204818, + "image_name": "13194.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 118.953, + 3407.427, + 412.707, + 109.9380000000001 + ], + "priority": 14, + "parents": [ + 111275 + ], + "children": [ + 111271, + 111266 + ], + "area": 405323.66393100005, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 111266, + "strid": "d4d3d814-2c71-402f-b99d-d94116a1bb80", + "image_id": 204818, + "image_name": "13194.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 119.663, + 3559.855, + 1541.861, + 138.2539999999999 + ], + "priority": 15, + "parents": [ + 111260 + ], + "children": [], + "area": 425982.92886499997, + "iscrowd": 0, + "segmentation": [], + "text": "To evaluate we use the Euclidean distance between each manual\nlabel and the label detected through our method." + }, + { + "id": 111271, + "strid": "d55ae051-09af-489a-ae2c-7ed29c51a393", + "image_id": 204818, + "image_name": "13194.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 91.616, + 3727.961, + 1617.282, + 903.127 + ], + "priority": 16, + "parents": [ + 111260 + ], + "children": [], + "area": 341540.874976, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 111262, + "strid": "bd765572-db8b-4a24-992d-b7f2355ae236", + "image_id": 204818, + "image_name": "13194.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1829.518, + 4228.947, + 1113.562, + 146.9380000000001 + ], + "priority": 17, + "parents": [ + 111275 + ], + "children": [ + 111268 + ], + "area": 7736934.657546001, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements" + }, + { + "id": 111268, + "strid": "6bec9276-a2cf-446c-acc6-9953b395855f", + "image_id": 204818, + "image_name": "13194.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1832.889, + 4392.421, + 1116.4020000000003, + 64.2529999999997 + ], + "priority": 18, + "parents": [ + 111262 + ], + "children": [], + "area": 8050820.134269, + "iscrowd": 0, + "segmentation": [], + "text": "Thanks to NeuroPoly colleagues for their support." + }, + { + "id": 111261, + "strid": "c0515d05-9c30-4128-8d81-a1250aecf12f", + "image_id": 204818, + "image_name": "13194.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1833.124, + 3413.704, + 619.6780000000001, + 106.86599999999999 + ], + "priority": 19, + "parents": [ + 111275 + ], + "children": [ + 111267 + ], + "area": 6257742.731296, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 111267, + "strid": "c9e22b00-fda6-42fd-b9f1-c5bb502307a8", + "image_id": 204818, + "image_name": "13194.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1828.699, + 3567.131, + 1586.801, + 533.1650000000004 + ], + "priority": 20, + "parents": [ + 111261 + ], + "children": [], + "area": 6523208.892569, + "iscrowd": 0, + "segmentation": [], + "text": "Lootus, M., Kadir, T., & Zisserman, A. (2014). Vertebrae detection\nand labelling in lumbar MR images. Lecture Notes in Computational\nVision and Biomechanics, 17, 219-230.\nhttps://doi.org/10.1007/978-3-319-07269-2_19\n\nUllmann, E., Francois, J., Paquette, P., Thong, W. E., & Cohen-Adad,\nJ. (2014). Automatic Labeling of Vertebral Levels Using a Robust\nTemplate-Based Approach. https://doi.org/10.1155/2014/719520" + }, + { + "id": 103308, + "strid": "25b5e0f1-1d3e-4662-8c7f-a9863bef5340", + "image_id": 204489, + "image_name": "122215.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 150.22, + 149.42, + 252.64000000000001, + 309.69000000000005 + ], + "priority": -1, + "parents": [], + "children": [ + 103306, + 103305, + 103290, + 103307, + 103283, + 103294, + 103282, + 103285, + 103293, + 103286, + 103284, + 103289, + 103301, + 103287, + 103303, + 103297, + 103281, + 103302, + 103304 + ], + "area": 22445.872399999997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 103281, + "strid": "2b00d492-93ba-4c80-899d-cd836ff87236", + "image_id": 204489, + "image_name": "122215.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 434.723, + 42.288, + 2672.644, + 235.30199999999996 + ], + "priority": 1, + "parents": [ + 103308 + ], + "children": [], + "area": 18383.566224, + "iscrowd": 0, + "segmentation": [], + "text": "Effects of a Renal Rehabilitation Exercise Program\nin Patients with CKD: Controlled Trial" + }, + { + "id": 103282, + "strid": "8146123c-cd37-49c6-97d7-f08d8a26ad6e", + "image_id": 204489, + "image_name": "122215.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 106.668, + 471.471, + 2841.712, + 321.937 + ], + "priority": 2, + "parents": [ + 103308 + ], + "children": [], + "area": 50290.868628000004, + "iscrowd": 0, + "segmentation": [], + "text": "Misa Miura!» , Aki Hirayama!), Shigeru Oowada?), Osamu Ito*), Masahiro Kohzuki*)\n\nDepartment of Health , Tsukuba Univerdity of Technology, Tsukuba, Japan\n*) Asao Clininic, Kawasaki, Japan\n\n>) Department of Internal Medicine and Rehabilitation Science, Tohoku University Graduate School of Medicine, Sendai, Japan" + }, + { + "id": 103283, + "strid": "0579536b-c4a6-457b-b67a-ce015f74f5ac", + "image_id": 204489, + "image_name": "122215.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 985.231, + 872.691, + 430.22399999999993, + 93.668 + ], + "priority": 3, + "parents": [ + 103308 + ], + "children": [ + 103291 + ], + "area": 859802.226621, + "iscrowd": 0, + "segmentation": [], + "text": "Objectives:" + }, + { + "id": 103291, + "strid": "33589310-4eac-4937-a183-41ce3925c473", + "image_id": 204489, + "image_name": "122215.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 147.879, + 1031.987, + 1229.27, + 723.143 + ], + "priority": 4, + "parents": [ + 103283 + ], + "children": [], + "area": 152609.205573, + "iscrowd": 0, + "segmentation": [], + "text": "Hemodialysis patients show reduced physical function\nand greater risk of arteriosclerosis because of\nhypertension, metabolic disturbances, and vascular\ncalcification. Meanwhile, exercise training in\nhemodialysis patients improves fitness, physical\nfunction, quality of life, and markers of cardiovascular\ndisease such as arterial stiffness. This study aimed to\ndetermine whether aerobic training and electrical\nstimulation to skeletal muscles for 12 weeks could\nimprove physical function and dialysis efficacy in\npatients with end-stage renal disease (ESRD)." + }, + { + "id": 103284, + "strid": "1970d771-6a16-4ef2-863e-9735785b7d42", + "image_id": 204489, + "image_name": "122215.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3064.738, + 872.161, + 367.6039999999998, + 78.005 + ], + "priority": 5, + "parents": [ + 103308 + ], + "children": [ + 103292 + ], + "area": 2672944.958818, + "iscrowd": 0, + "segmentation": [], + "text": "Methods:" + }, + { + "id": 103292, + "strid": "031596a6-e6ae-4b6e-9b57-a9012c4cb9aa", + "image_id": 204489, + "image_name": "122215.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1549.167, + 1039.226, + 1861.022, + 657.992 + ], + "priority": 6, + "parents": [ + 103284 + ], + "children": [], + "area": 1609934.6247420001, + "iscrowd": 0, + "segmentation": [], + "text": "This was a controlled clinical trial. A total of 30 ESRD patients (18 males, 12\nfemales; age: 72.9+7.7 years) (table) were randomized to receive 12 weeks of\naerobic training exercise during hemodialysis session (Ex-group: n=14), electrical\nstimulation to the lower limbs (ES-group: n=6), or no specific intervention (Cont-\ngroup: n=10).\n\nThe Borg scale was used to control the intensity of training. At baseline and study\ncompletion, the primary outcome measures were grip strength, quad muscle torque,\nworkout time, activities, dialysis efficacy, HDL-cholesterol, LDL-cholesterol, C-\nreactive protein (CRP), Interleukin-6 (IL-6) and blood pressure on the morning of\nthe dialysis day." + }, + { + "id": 103305, + "strid": "9b1b687b-0c6e-4203-8560-3628f1468420", + "image_id": 204489, + "image_name": "122215.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 97.983, + 1851.537, + 1348.45, + 941.3709999999999 + ], + "priority": 7, + "parents": [ + 103308 + ], + "children": [], + "area": 181419.149871, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 103306, + "strid": "6cb4cc1b-34ad-46f4-91b7-a717ec7c20b2", + "image_id": 204489, + "image_name": "122215.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1503.41, + 1833.539, + 788.7239999999999, + 388.7059999999999 + ], + "priority": 8, + "parents": [ + 103308 + ], + "children": [], + "area": 2756560.86799, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 103293, + "strid": "1e19d328-9a37-4f87-b9f8-ae389e04a517", + "image_id": 204489, + "image_name": "122215.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1511.641, + 2238.839, + 749.719, + 188.59400000000005 + ], + "priority": 9, + "parents": [ + 103308 + ], + "children": [], + "area": 3384320.8247990003, + "iscrowd": 0, + "segmentation": [], + "text": "aerobic training exercise\n( Terasu Erugo, Showa-denki inc,\n\nOsaka, Japan)" + }, + { + "id": 103289, + "strid": "7a83bb46-6900-4fba-ad96-841f6b0be572", + "image_id": 204489, + "image_name": "122215.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1518.45, + 2451.602, + 678.4819999999997, + 312.10199999999986 + ], + "priority": 10, + "parents": [ + 103308 + ], + "children": [], + "area": 3722635.0568999997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 103307, + "strid": "3a2ddb64-5988-4ecb-82a6-605225263d37", + "image_id": 204489, + "image_name": "122215.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2372.343, + 1832.511, + 1092.0789999999997, + 316.72400000000016 + ], + "priority": 11, + "parents": [ + 103308 + ], + "children": [], + "area": 4347344.643273, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 103294, + "strid": "d18de648-5a42-4e84-a2be-961976c3716b", + "image_id": 204489, + "image_name": "122215.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2385.169, + 2165.151, + 1011.931, + 188.087 + ], + "priority": 12, + "parents": [ + 103308 + ], + "children": [], + "area": 5164251.045518999, + "iscrowd": 0, + "segmentation": [], + "text": "Position of electrods (lower limb extensors)\nPortable battery-powered stimulator(REHAB\nX-2 Cefar, Malmo, Sweden)" + }, + { + "id": 103290, + "strid": "d83d579c-2147-427f-8a5a-52f26de25bf5", + "image_id": 204489, + "image_name": "122215.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2392.712, + 2379.963, + 1004.6990000000001, + 389.41100000000006 + ], + "priority": 13, + "parents": [ + 103308 + ], + "children": [], + "area": 5694566.029656, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 103303, + "strid": "1a55f4e4-4c82-49a0-ac56-00b5ca2c8b99", + "image_id": 204489, + "image_name": "122215.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 86.63, + 2945.595, + 1449.029, + 669.8420000000001 + ], + "priority": 14, + "parents": [ + 103308 + ], + "children": [ + 103298 + ], + "area": 255176.89484999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 103298, + "strid": "72ece230-a9b9-47a0-9b43-ba23be0002fe", + "image_id": 204489, + "image_name": "122215.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 98.326, + 2865.304, + 1338.912, + 60.402000000000044 + ], + "priority": 15, + "parents": [ + 103303 + ], + "children": [], + "area": 281733.881104, + "iscrowd": 0, + "segmentation": [], + "text": "Table. Demographic and clinical parameters of the subjects." + }, + { + "id": 103304, + "strid": "90ba3341-a3be-42ea-ab3f-02c803dc9503", + "image_id": 204489, + "image_name": "122215.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 90.442, + 3622.824, + 923.13, + 56.42599999999993 + ], + "priority": 16, + "parents": [ + 103308 + ], + "children": [], + "area": 327655.448208, + "iscrowd": 0, + "segmentation": [], + "text": "Values are presented as the mean + S.D." + }, + { + "id": 103302, + "strid": "da0aab21-2848-4502-aae4-d41ebdec0e44", + "image_id": 204489, + "image_name": "122215.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1634.194, + 2896.021, + 809.5450000000001, + 760.2800000000002 + ], + "priority": 17, + "parents": [ + 103308 + ], + "children": [ + 103299 + ], + "area": 4732660.142074, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 103299, + "strid": "13f5202f-c9e8-4fcb-9419-b030d813978c", + "image_id": 204489, + "image_name": "122215.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1636.319, + 2851.539, + 568.1950000000002, + 53.929999999999836 + ], + "priority": 18, + "parents": [ + 103302 + ], + "children": [], + "area": 4666027.444941, + "iscrowd": 0, + "segmentation": [], + "text": "Fig.1 Change of LDL-C" + }, + { + "id": 103301, + "strid": "1e6da152-1e93-4c13-827e-a8cab482ec4d", + "image_id": 204489, + "image_name": "122215.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2635.827, + 2918.112, + 800.2660000000001, + 741.0100000000002 + ], + "priority": 19, + "parents": [ + 103308 + ], + "children": [ + 103300 + ], + "area": 7691638.398624001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 103300, + "strid": "51cec4e5-2a23-47d6-9ede-1792436ddb09", + "image_id": 204489, + "image_name": "122215.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2644.259, + 2858.334, + 686.328, + 57.84400000000005 + ], + "priority": 20, + "parents": [ + 103301 + ], + "children": [], + "area": 7558175.404506, + "iscrowd": 0, + "segmentation": [], + "text": "Fig.2 Change of Quard torque" + }, + { + "id": 103285, + "strid": "cad187be-9cd0-474d-bf8e-3f98141196e3", + "image_id": 204489, + "image_name": "122215.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2363.107, + 3729.855, + 312.41600000000017, + 79.7460000000001 + ], + "priority": 21, + "parents": [ + 103308 + ], + "children": [ + 103295 + ], + "area": 8814046.459485, + "iscrowd": 0, + "segmentation": [], + "text": "Results:" + }, + { + "id": 103295, + "strid": "459cf8f2-0367-4356-8e59-b36bbf07f7a3", + "image_id": 204489, + "image_name": "122215.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 114.927, + 3887.882, + 2524.936, + 539.0329999999999 + ], + "priority": 22, + "parents": [ + 103285 + ], + "children": [], + "area": 446822.614614, + "iscrowd": 0, + "segmentation": [], + "text": "No significant differences between the three groups were noted for the characteristics at the baseline. Data\nanalysis revealed statistically significant improvements of patients in the Ex-group(averaged difference after 12\nweeks of exercise as related to initial value: Ahand grip: +8.6%, A quad torque: +8.3%, Awork out time:+190%,\nAactivities: +59.9%, ADialysis efficacy: +7.7%, AHDL-cholesterol:-9.2%, ALDL-cholesterol:- 10.4%, ACRP: -\n57.1%, Ablood pressure on the morning of the dialysis day: -8.9% ). These effects were not observed in the Cont-\ngroup. Meanwhile, in the ES-group(averaged difference after 12 weeks of exercise as related to initial value: A\nquad torque: +33.4%, ADialysis efficacy: +6.7%), while the other parameters did not change. Significant\ndifference among three groups were found Quad torque and hand grip." + }, + { + "id": 103286, + "strid": "5d63b3b8-c59f-4d59-bcc6-c2b0b1b2820a", + "image_id": 204489, + "image_name": "122215.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2164.996, + 4526.662, + 514.2129999999997, + 76.65700000000015 + ], + "priority": 23, + "parents": [ + 103308 + ], + "children": [ + 103296 + ], + "area": 9800205.123352, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions:" + }, + { + "id": 103296, + "strid": "77e626fc-9e44-426c-9a69-c18e238a3bc7", + "image_id": 204489, + "image_name": "122215.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 115.522, + 4692.761, + 2496.687, + 259.7439999999997 + ], + "priority": 24, + "parents": [ + 103286 + ], + "children": [], + "area": 542117.136242, + "iscrowd": 0, + "segmentation": [], + "text": "In this study, the safety and efficacy of training and electrical stimulation during hemodialysis were confirmed\nwithout sudden drop of blood pressure or any other side effects. Therefore, training during hemodialysis session\nfor 12 weeks might improve physical function with specific whole-body effects as well as local effects in ESRD\npatients." + }, + { + "id": 103297, + "strid": "a2a84157-0b43-4a53-b66e-0752a725850e", + "image_id": 204489, + "image_name": "122215.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 77.828, + 5025.725, + 2564.983, + 56.42199999999957 + ], + "priority": 25, + "parents": [ + 103308 + ], + "children": [], + "area": 391142.1253, + "iscrowd": 0, + "segmentation": [], + "text": "COI Disclosure :This presentation is not related to any company with a conflict of interest that should be disclosed." + }, + { + "id": 103287, + "strid": "b72339f4-ea8a-4c75-a3e1-c7f7f84290b7", + "image_id": 204489, + "image_name": "122215.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2839.927, + 3747.64, + 341.61400000000003, + 59.5630000000001 + ], + "priority": 26, + "parents": [ + 103308 + ], + "children": [ + 103288 + ], + "area": 10643024.02228, + "iscrowd": 0, + "segmentation": [], + "text": "References:" + }, + { + "id": 103288, + "strid": "0ee1d203-b335-48e7-ae2c-9129d631df13", + "image_id": 204489, + "image_name": "122215.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2835.727, + 3875.68, + 584.576, + 993.4509999999996 + ], + "priority": 27, + "parents": [ + 103287 + ], + "children": [], + "area": 10990370.419359999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 101167, + "strid": "ac570262-1cb6-4ef5-a99c-c4f7e1325e86", + "image_id": 204408, + "image_name": "122063.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 233.86, + 150.91, + 185.33999999999997, + 278.01 + ], + "priority": -1, + "parents": [], + "children": [ + 101128, + 101163, + 101133, + 101162, + 101137, + 101130, + 101131, + 101132, + 101136, + 101134, + 101135, + 101129 + ], + "area": 35291.812600000005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 101128, + "strid": "f08e242f-f7d5-469f-a2f4-c8c19a2450a8", + "image_id": 204408, + "image_name": "122063.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 657.817, + 144.274, + 3474.1099999999997, + 120.55200000000002 + ], + "priority": 1, + "parents": [ + 101167 + ], + "children": [], + "area": 94905.889858, + "iscrowd": 0, + "segmentation": [], + "text": "A Novel Pre-clinical Model of Cancer-Induced Depression" + }, + { + "id": 101129, + "strid": "98273b76-5a7a-4103-9978-afb0b5800a88", + "image_id": 204408, + "image_name": "122063.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1207.31, + 301.924, + 2386.248, + 127.88900000000001 + ], + "priority": 2, + "parents": [ + 101167 + ], + "children": [], + "area": 364515.86444, + "iscrowd": 0, + "segmentation": [], + "text": "Mina Nashed, Eric SeidlitzGurmit Singh\nMcMaster University, Department of Pathology & Molecular Medicine, Hamilton, Ontario, Canada" + }, + { + "id": 101130, + "strid": "52e50e1b-7ec1-4524-a4b8-30a1cc24734a", + "image_id": 204408, + "image_name": "122063.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 102.828, + 533.561, + 432.2320000000001, + 41.98599999999999 + ], + "priority": 3, + "parents": [ + 101167 + ], + "children": [ + 101138 + ], + "area": 54865.01050800001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 101138, + "strid": "9c0d75a4-5230-49be-970b-a84c0ffb2fcf", + "image_id": 204408, + "image_name": "122063.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 92.342, + 640.066, + 1220.04, + 768.0069999999998 + ], + "priority": 4, + "parents": [ + 101130 + ], + "children": [], + "area": 59104.974572, + "iscrowd": 0, + "segmentation": [], + "text": "Depression has a dramatic impact on the quality of life and\nsurvivorship of cancer patients. While the prevalence of depression is\napproximately 8-12% in the general population, the Canadian Mental\nHealth Association estimates that nearly 42% of cancer inpatients will\nexperience depression (Canadian Mental Health Association, 2009). In\naddition to the psychosocial impact of a cancer diagnosis, evidence\nsuggests that depression symptoms actually precede the diagnosis of\ncancer (Van Esch et al., 2012). Furthermore, the common symptom\ncluster of pain-depression-fatigue suggests that common biological\nmechanisms may be involved. In the absence of a validated animal\nmodel to study cancer-induced depression (CID), little progress has\nbeen made in characterizing these mechanisms. The primary objective\nof this study is to establish a pre-clinical model of CID, which will allow\nfor the investigation of mechanisms and novel drug targets." + }, + { + "id": 101131, + "strid": "0fde9dc4-dc9e-4ffc-8c78-09b72f71ad95", + "image_id": 204408, + "image_name": "122063.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 102.194, + 1490.233, + 352.294, + 39.79099999999994 + ], + "priority": 5, + "parents": [ + 101167 + ], + "children": [ + 101139 + ], + "area": 152292.871202, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 101139, + "strid": "a256b349-ecd1-41d6-bf08-fc647a960f6f", + "image_id": 204408, + "image_name": "122063.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 89.912, + 1597.122, + 1218.115, + 99.47000000000003 + ], + "priority": 6, + "parents": [ + 101131 + ], + "children": [], + "area": 143600.43326400002, + "iscrowd": 0, + "segmentation": [], + "text": "We hypothesize that subcutaneous tumour induction using 4T1 murine\nbreast cancer cells in BALB/c mice will induce a depressive state" + }, + { + "id": 101132, + "strid": "4e997393-434a-4244-8028-c1f26708d6d0", + "image_id": 204408, + "image_name": "122063.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 104.784, + 1777.902, + 268.956, + 40.031999999999925 + ], + "priority": 7, + "parents": [ + 101167 + ], + "children": [ + 101155, + 101151, + 101150, + 101147, + 101154, + 101149, + 101148 + ], + "area": 186295.68316800002, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 101147, + "strid": "f0f76feb-a366-494e-b4fe-f0add6409401", + "image_id": 204408, + "image_name": "122063.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 94.447, + 1880.171, + 346.84, + 74.36699999999996 + ], + "priority": 8, + "parents": [ + 101132 + ], + "children": [], + "area": 177576.51043700002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 101148, + "strid": 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Using these tests, we were able to\nestablish a validated model of CID. The present CID model can be\nused to investigate CID mechanisms and novel drug targets." + }, + { + "id": 101136, + "strid": "73522cb5-8c98-4c5c-b31f-39206c700ef0", + "image_id": 204408, + "image_name": "122063.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3532.893, + 2722.135, + 580.5290000000005, + 41.396000000000186 + ], + "priority": 36, + "parents": [ + 101167 + ], + "children": [ + 101142 + ], + "area": 9617011.686555, + "iscrowd": 0, + "segmentation": [], + "text": "FUTURE DIRECTIONS" + }, + { + "id": 101142, + "strid": "b33ab211-0722-4697-beda-2f5479337b34", + "image_id": 204408, + "image_name": "122063.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3535.71, + 2823.372, + 1214.3400000000001, + 467.1109999999999 + ], + "priority": 37, + "parents": [ + 101136 + ], + "children": [], + "area": 9982624.61412, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 101137, + "strid": "3059eb99-7b57-4e1b-b2a8-0567ea2853e6", + "image_id": 204408, + "image_name": "122063.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3533.36, + 3352.97, + 218.57799999999997, + 32.083000000000084 + ], + "priority": 38, + "parents": [ + 101167 + ], + "children": [ + 101141 + ], + "area": 11847250.0792, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 101141, + "strid": "3bf1cd15-d81f-4779-a468-bf7a2b1b977d", + "image_id": 204408, + "image_name": "122063.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3534.33, + 3426.44, + 1208.8009999999995, + 84.08800000000019 + ], + "priority": 39, + "parents": [ + 101137 + ], + "children": [], + "area": 12110169.6852, + "iscrowd": 0, + "segmentation": [], + "text": "Canadian Mental Health Association, Depression and Co-Existing Conditions, (2009).\nVan Esch L, Roukema JA, Ernst MF, Nieuwenhuijzen GA, De Vries J. Combined anxiety and depressive symptoms before\ndiagnosis of breast cancer. Journal of affective disorders. 2012;136(3):895-901." + }, + { + "id": 128850, + "strid": "6cf36f1c-9371-465a-a8a3-113ae344903b", + "image_id": 205515, + "image_name": "15264.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 102.45, + 0, + 221.26, + 270.77 + ], + "priority": -1, + "parents": [], + "children": [ + 128837, + 128834, + 128838, + 128824, + 128823, + 128846, + 128825, + 128848, + 128843 + ], + "area": 0.0, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 128823, + "strid": "fefa4671-c5a5-417f-8b8d-49823760fea3", + "image_id": 205515, + "image_name": "15264.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 210.863, + 265.274, + 2203.005, + 194.70100000000002 + ], + "priority": 1, + "parents": [ + 128850 + ], + "children": [], + "area": 55936.471462, + "iscrowd": 0, + "segmentation": [], + "text": "Nanopore base-calling from a perspective of instance\nsegmentation" + }, + { + "id": 128824, + "strid": "473f43a0-f32a-40f8-b0c2-b4adf4c3c1db", + "image_id": 205515, + "image_name": "15264.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 211.571, + 549.109, + 2188.631, + 318.91600000000005 + ], + "priority": 2, + "parents": [ + 128850 + ], + "children": [], + "area": 116175.54023900001, + "iscrowd": 0, + "segmentation": [], + "text": "Yao-zhong Zhang'*, Arda Akdemir', Georg Tremmel', Seiya Imoto!, Satoru Miyano!, Tetsuo Shibuya! and\nRui Yamaguchi?\n\n‘Institute of Medical Science, the University of Tokyo, Tokyo, 108-0071, Japan\n?Aichi Cancer Center Research Institute, Nagoya, 464-8681, Japan\n\n*vaozhong@ims.u-tokyo.ac.jp" + }, + { + "id": 128825, + "strid": "6dbb25d9-9085-4efd-9012-9023cd89b308", + "image_id": 205515, + "image_name": "15264.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 195.392, + 998.173, + 354.50000000000006, + 52.718000000000075 + ], + "priority": 3, + "parents": [ + 128850 + ], + "children": [ + 128829, + 128828, + 128830, + 128831, + 128826, + 128832 + ], + "area": 195035.018816, + "iscrowd": 0, + "segmentation": [], + "text": "1 Methodology" + }, + { + "id": 128826, + "strid": "e08cae61-1504-430b-bccb-e8f391e3e4b7", + "image_id": 205515, + "image_name": "15264.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 199.214, + 1084.222, + 1401.009, + 329.42599999999993 + ], + "priority": 4, + "parents": [ + 128825 + ], + "children": [], + "area": 215992.201508, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 128828, + "strid": "fb9deb07-9d7d-4905-994a-e71838144813", + "image_id": 205515, + "image_name": "15264.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 196.823, + 1536.343, + 1042.72, + 67.85400000000004 + ], + "priority": 5, + "parents": [ + 128825 + ], + "children": [], + "area": 302387.638289, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 128829, + "strid": "ae6cac48-bc78-4d58-b9ce-5aa975cb7bcc", + "image_id": 205515, + "image_name": "15264.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 238.787, + 1618.217, + 1305.027, + 564.7530000000002 + ], + "priority": 6, + "parents": [ + 128825 + ], + "children": [ + 128827 + ], + "area": 386409.182779, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 128827, + "strid": "6b48b493-fe00-45b8-afd9-48a5e492bc3e", + "image_id": 205515, + "image_name": "15264.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 195.852, + 1501.087, + 601.267, + 32.146999999999935 + ], + "priority": 7, + "parents": [ + 128829 + ], + "children": [], + "area": 293990.891124, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1: Overall structure of URnano baser-caller." + }, + { + "id": 128830, + "strid": "6e04efda-e892-4424-94f4-534c63756086", + "image_id": 205515, + "image_name": "15264.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 189.586, + 2302.761, + 1402.907, + 487.83399999999983 + ], + "priority": 8, + "parents": [ + 128825 + ], + "children": [], + "area": 436571.246946, + "iscrowd": 0, + "segmentation": [], + "text": "1.1 Basecalling\n\nSignal currency values for each read are divided into fixed-length non-overlapping windows during\ntraining. For basecalling we used a step size of 30 with window length 300 and merged consecutive\npredictions to increase the basecalling accuracy.\n\nWe use label masks{ Aj, C),G 1,7} and {A9, C2, Go,T>} to represent 4 nucleotides. Consecu-\ntive bases with identical nucleotides are labeled by alternating between X, and X9. (e.g AAA >\nA,A2Aj). This way, we are able to decode the basecalling results unambiguously for homopolymer\nregions.\n\nInput: Fixed-length (300 by default) signal currency (x;)\nOutput: Basecalling prediction with label masks (X 1, X2) of same length as the input signal" + }, + { + "id": 128831, + "strid": "f8070099-d038-4757-92d0-06dedfc94221", + "image_id": 205515, + "image_name": "15264.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 193.229, + 2842.245, + 1404.869, + 453.3270000000002 + ], + "priority": 9, + "parents": [ + 128825 + ], + "children": [], + "area": 549204.159105, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 128832, + "strid": "e8b0cb69-bc1c-491f-85fa-45a397f0d12e", + "image_id": 205515, + "image_name": "15264.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 598.151, + 3343.442, + 519.476, + 234.0300000000002 + ], + "priority": 10, + "parents": [ + 128825 + ], + "children": [ + 128833 + ], + "area": 1999883.1757419999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 128833, + "strid": "e2e1b870-a2c0-4417-a8cb-7a3da1946793", + "image_id": 205515, + "image_name": "15264.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 365.686, + 3614.288, + 1051.57, + 33.346000000000004 + ], + "priority": 11, + "parents": [ + 128832 + ], + "children": [], + "area": 1321694.5215679999, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2: An example on merging base-calls of overlapped slide window for a whole read." + }, + { + "id": 128834, + "strid": "8394c528-46b7-4d2a-999e-bc2c0b8c79b0", + "image_id": 205515, + "image_name": "15264.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 195.704, + 3719.22, + 236.95300000000003, + 43.47699999999986 + ], + "priority": 12, + "parents": [ + 128850 + ], + "children": [ + 128835 + ], + "area": 727866.23088, + "iscrowd": 0, + "segmentation": [], + "text": "2 Results" + }, + { + "id": 128835, + "strid": "a30c2a45-05f1-4046-a69a-15279a5b7bf3", + "image_id": 205515, + "image_name": "15264.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 196.405, + 3799.967, + 1396.687, + 691.5660000000003 + ], + "priority": 13, + "parents": [ + 128834 + ], + "children": [], + "area": 746332.518635, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 128848, + "strid": "439b2c71-848b-4a2c-a654-828cc21db11c", + "image_id": 205515, + "image_name": "15264.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2312.168, + 994.613, + 206.01999999999998, + 41.20399999999995 + ], + "priority": 14, + "parents": [ + 128850 + ], + "children": [ + 128849 + ], + "area": 2299712.350984, + "iscrowd": 0, + "segmentation": [], + "text": "Segmentation" + }, + { + "id": 128849, + "strid": "22cf4df4-4c8f-4b34-acda-990530c871b7", + "image_id": 205515, + "image_name": "15264.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1828.837, + 1170.126, + 1161.8520000000003, + 822.2340000000002 + ], + "priority": 15, + "parents": [ + 128848 + ], + "children": [ + 128847 + ], + "area": 2139969.723462, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 128847, + "strid": "8190f375-3a7e-4283-b584-0f3bb0e68130", + "image_id": 205515, + "image_name": "15264.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1716.578, + 1087.578, + 1400.7400000000002, + 73.31700000000001 + ], + "priority": 16, + "parents": [ + 128849 + ], + "children": [], + "area": 1866912.4680839998, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3: An example of base-calling results by Chiron and URnano for the sequence of “TACTTACTCAACAATGCGT-\nTAAATTTCGACTGTTTA”. A dotted vertical line indicates the start position of a nucleotide segment." + }, + { + "id": 128846, + "strid": "a3ddd265-9c40-4dd2-9f71-a70c64dca403", + "image_id": 205515, + "image_name": "15264.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2221.15, + 2093.406, + 387.24400000000014, + 47.21399999999994 + ], + "priority": 17, + "parents": [ + 128850 + ], + "children": [ + 128844 + ], + "area": 4649768.7369, + "iscrowd": 0, + "segmentation": [], + "text": "Normalized Edit Distance" + }, + { + "id": 128844, + "strid": "01673477-6800-4f29-8703-0c8c8bd7bf6f", + "image_id": 205515, + "image_name": "15264.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2126.416, + 2223.732, + 569.1930000000002, + 252.15200000000004 + ], + "priority": 18, + "parents": [ + 128846 + ], + "children": [ + 128845 + ], + "area": 4728579.304512001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 128845, + "strid": "9567dce0-52ff-424f-b3b9-75858a883f23", + "image_id": 205515, + "image_name": "15264.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1787.906, + 2185.984, + 1252.591, + 29.35199999999986 + ], + "priority": 19, + "parents": [ + 128844 + ], + "children": [], + "area": 3908333.9095039996, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1: NED of different base-callers and network architectures for non-overlapping window in the test set." + }, + { + "id": 128843, + "strid": "9c2b1131-985a-49c5-95d2-8bd0803c1e38", + "image_id": 205515, + "image_name": "15264.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2300.092, + 2599.399, + 228.96799999999985, + 43.20199999999977 + ], + "priority": 20, + "parents": [ + 128850 + ], + "children": [ + 128841 + ], + "area": 5978856.844708, + "iscrowd": 0, + "segmentation": [], + "text": "Read Accuracy" + }, + { + "id": 128841, + "strid": "08731676-9ca1-476b-b98d-16da63a1bb7d", + "image_id": 205515, + "image_name": "15264.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1763.998, + 2764.003, + 1301.0499999999997, + 587.0210000000002 + ], + "priority": 21, + "parents": [ + 128843 + ], + "children": [ + 128842 + ], + "area": 4875695.763994001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 128842, + "strid": "15c7becc-62ff-4b74-b3cf-8877c475604b", + "image_id": 205515, + "image_name": "15264.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1719.864, + 2692.399, + 1394.5949999999998, + 66.49099999999999 + ], + "priority": 22, + "parents": [ + 128841 + ], + "children": [], + "area": 4630560.113736, + "iscrowd": 0, + "segmentation": [], + "text": "Table 2: Results of read accuracy on the test set. Note that ONT base-callers in gray-color line is trained on a larger\ndateset, which are used as references. We mainly compared the performances of Chiron and URnano." + }, + { + "id": 128838, + "strid": "3f3eed3b-fcd7-40e6-8c78-1c63320d809e", + "image_id": 205515, + "image_name": "15264.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2342.598, + 3435.649, + 146.83899999999994, + 41.001000000000204 + ], + "priority": 23, + "parents": [ + 128850 + ], + "children": [ + 128839 + ], + "area": 8048344.476101999, + "iscrowd": 0, + "segmentation": [], + "text": "Assembly" + }, + { + "id": 128839, + "strid": "e252a39c-b160-4021-825e-2b1b487a729e", + "image_id": 205515, + "image_name": "15264.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2024.97, + 3600.956, + 773.104, + 543.0889999999999 + ], + "priority": 24, + "parents": [ + 128838 + ], + "children": [ + 128840 + ], + "area": 7291827.87132, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 128840, + "strid": "b1348c25-9c62-4a4b-8a70-f189a2c0b661", + "image_id": 205515, + "image_name": "15264.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1720.016, + 3526.562, + 1394.797, + 67.54700000000003 + ], + "priority": 25, + "parents": [ + 128839 + ], + "children": [], + "area": 6065743.064992, + "iscrowd": 0, + "segmentation": [], + "text": "Table 3: Evaluation with assembly on the test set. Note that ONT base-callers in gray-color line is trained on a larger\ndateset, which are used as references." + }, + { + "id": 128837, + "strid": "059c2045-3ea7-4d65-95cf-e3dfe2dd2ab1", + "image_id": 205515, + "image_name": "15264.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1719.961, + 4230.928, + 411.8549999999998, + 51.87700000000041 + ], + "priority": 26, + "parents": [ + 128850 + ], + "children": [ + 128836 + ], + "area": 7277031.153808, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements" + }, + { + "id": 128836, + "strid": "8a45062b-63f9-4901-8c07-2ef82f420aff", + "image_id": 205515, + "image_name": "15264.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1716.145, + 4327.216, + 1407.5819999999999, + 160.5659999999998 + ], + "priority": 27, + "parents": [ + 128837 + ], + "children": [], + "area": 7426130.1023200005, + "iscrowd": 0, + "segmentation": [], + "text": "This work is funded by the project of conquering cancer through neo-dimensional systems under-\nstanding (Grant-in-Aid for Scientific Research on Innovative Areas from the Ministry of Education,\nCulture, Sports, Science and Technology, Japan) and was partially supported by JST CREST Grant\nNumber JPMJCR1402, JSPS KAKENHI Grant Numbers 17H01693, and 17K20023JST." + }, + { + "id": 160988, + "strid": "16257d6b-c71d-4fad-8707-bd7d8dacdbb1", + "image_id": 206784, + "image_name": "6425.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 159.7, + 180.5, + 237.74, + 188.20999999999998 + ], + "priority": -1, + "parents": [], + "children": [ + 160973, + 160971, + 160976, + 160970, + 160975, + 160972, + 160974 + ], + "area": 28825.85, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 160970, + "strid": "a19fb00c-865e-4565-8436-4b3b2ba5b099", + "image_id": 206784, + "image_name": "6425.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 445.134, + 165.22, + 2301.742, + 251.59899999999996 + ], + "priority": 1, + "parents": [ + 160988 + ], + "children": [], + "area": 73545.03948, + "iscrowd": 0, + "segmentation": [], + "text": "Investigating intra-tumour heterogeneity in\nprostate cancer using structural variation" + }, + { + "id": 160971, + "strid": "988b06eb-6ffb-43f8-8ea3-0a3a58d8bbc2", + "image_id": 206784, + "image_name": "6425.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 354.772, + 586.74, + 2577.22, + 44.15999999999997 + ], + "priority": 2, + "parents": [ + 160988 + ], + "children": [], + "area": 208158.92328, + "iscrowd": 0, + "segmentation": [], + "text": "MAREK CMERO'28, Niall Corcoran'?, Christopher M Hovens', Ke Yuan®, Florian Markowetz®, Cheng Soon Ong*®”8, Geoff Macintyre*®" + }, + { + "id": 160972, + "strid": "14f22d9b-a809-4b16-8366-2c72d086e9fa", + "image_id": 206784, + "image_name": "6425.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 119.671, + 778.693, + 509.676, + 49.571000000000026 + ], + "priority": 3, + "parents": [ + 160988 + ], + "children": [ + 160984, + 160977, + 160978 + ], + "area": 93186.97000300001, + "iscrowd": 0, + "segmentation": [], + "text": "Method overview" + }, + { + "id": 160977, + "strid": "049ee456-69cc-447f-aa20-2a9f3cdef7ac", + "image_id": 206784, + "image_name": "6425.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 129.679, + 902.612, + 1378.263, + 364.227 + ], + "priority": 4, + "parents": [ + 160972 + ], + "children": [], + "area": 117049.82154799999, + "iscrowd": 0, + "segmentation": [], + "text": "We obtain split, discordant and normal read counts from structural variation\n(SV) events using whole-genome sequencing data. The SVs are then filtered to\nobtain high-confidence somatic variants. We then use a Bayesian hierarchical\nmodel approach to approximate the posterior cellular frequencies of the variant\ntumour populations from the count data, treating all SVs as independent. In\norder to avoid fixing the number of populations a-priori, we implement a\nDirichlet Process (DP) with an upper bound K. The generative DP model is\nshown below." + }, + { + "id": 160978, + "strid": "0ffd855f-a91d-4d8c-a40f-9173cb92736a", + "image_id": 206784, + "image_name": "6425.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 132.423, + 1306.552, + 457.94100000000003, + 833.4170000000001 + ], + "priority": 5, + "parents": [ + 160972 + ], + "children": [], + "area": 173017.535496, + "iscrowd": 0, + "segmentation": [], + "text": "T = tumour purity\ny =ploidy\n$9 = uniform prior on @;\no; = population frequency\nn; = normal reads\nb; = variant reads\n(split + spanning)\n\nH, a are prior distributions\npis a draw from a stick-\nbreaking Dirichlet process\n\nWU is the most likely CNV\nstate for the ref + var pops\n\nWe cluster i€1..N structure\nvariations constrained by\nz,€1..K clusters" + }, + { + "id": 160984, + "strid": "5c6b39f5-a3a8-4ed0-92c9-e19000a2351b", + "image_id": 206784, + "image_name": "6425.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 603.119, + 1332.214, + 880.833, + 773.065 + ], + "priority": 6, + "parents": [ + 160972 + ], + "children": [], + "area": 803483.575466, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 160975, + "strid": "81a831ad-c11f-4eed-8ff9-3f9584b6f1b8", + "image_id": 206784, + "image_name": "6425.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 112.479, + 2263.858, + 982.6319999999998, + 66.76000000000022 + ], + "priority": 7, + "parents": [ + 160988 + ], + "children": [ + 160981, + 160985 + ], + "area": 254636.483982, + "iscrowd": 0, + "segmentation": [], + "text": "Handling Copy-number variation" + }, + { + "id": 160985, + "strid": "eeabe2b7-0ed3-4bb5-b056-a1b463b29a37", + "image_id": 206784, + "image_name": "6425.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 145.499, + 2438.443, + 1356.758, + 700.5129999999999 + ], + "priority": 8, + "parents": [ + 160975 + ], + "children": [], + "area": 354791.018057, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 160981, + "strid": "f3480270-0e08-4940-a233-45e99ae758ea", + "image_id": 206784, + "image_name": "6425.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 147.727, + 3218.879, + 1346.191, + 652.364 + ], + "priority": 9, + "parents": [ + 160975 + ], + "children": [], + "area": 475515.338033, + "iscrowd": 0, + "segmentation": [], + "text": "Our approach assumes that a sample is made up of three cellular populations with\ndifferent frequencies: i) the normal population, representing the fraction of normal\ntissue in the sample; ii) the non-variant tumour population; and ii) the variant\npopulation that contains the SV. The relative proportions are shown above, where\nCp = the reference copy-number, C, = the total variant population copy-number, C,,y\n= the allele copy-number containing the variant and C,,= the allele copy-number\nnot containing the variant. We always assume the normal proportion has a normal\ndiploid copy-number of 2. Y; represents all copy-number states given the subclonal\ncopy-numbers, which we obtain using the Battenberg algorithm’. We iterate over all\npossible CNV configurations for the reference and variant populations, as well as\neach possible variant allele proportion, and select the most likely CNV state. This\nlikelinood is calculated using a binomial likelihood function, with an observed value\nof variant reads b,, given the number of trials, depth n; + b,, and probability equal to\nthe likelihood of sampling a variant read (€), given the CNV state (w;), tumour purity\n(tr) and population frequency (4)." + }, + { + "id": 160973, + "strid": "9faf42fb-10e0-4289-8f8e-a1f59985c396", + "image_id": 206784, + "image_name": "6425.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1753.58, + 780.523, + 368.90499999999975, + 57.144000000000005 + ], + "priority": 10, + "parents": [ + 160988 + ], + "children": [ + 160979 + ], + "area": 1368709.52234, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 160979, + "strid": "953e753c-cd65-42fb-9e82-5ce683f46548", + "image_id": 206784, + "image_name": "6425.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1762.669, + 890.115, + 1430.619, + 460.6410000000001 + ], + "priority": 11, + "parents": [ + 160973 + ], + "children": [], + "area": 1568978.116935, + "iscrowd": 0, + "segmentation": [], + "text": "Many approaches have arisen for inferring the evolutionary\ndynamics of tumour cell populations from point-mutation and\ncopy-number data. However, there are currently no methods\nwhich incorporate structural variants (SVs). We present a method\nSVclone for inferring the subclonal make-up of tumour samples\nusing large-scale genomic rearrangements obtained from whole-\ngenome sequencing data. This approach is particularly useful for\nSV driven tumours such as prostate cancer." + }, + { + "id": 160974, + "strid": "f88ccb83-fe03-4859-8404-146001e18248", + "image_id": 206784, + "image_name": "6425.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1758.639, + 1508.182, + 221.85099999999989, + 49.38599999999997 + ], + "priority": 12, + "parents": [ + 160988 + ], + "children": [ + 160986, + 160982, + 160987, + 160980 + ], + "area": 2652347.684298, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 160980, + "strid": "8a5859aa-7f7e-4aa6-93d0-c38fbce831a1", + "image_id": 206784, + "image_name": "6425.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1760.383, + 1637.681, + 1398.6199999999997, + 333.13300000000004 + ], + "priority": 13, + "parents": [ + 160974 + ], + "children": [], + "area": 2882945.791823, + "iscrowd": 0, + "segmentation": [], + "text": "We ran SVclone with SVs called by Socrates* on moderate coverage (~50x)\nwhole-genome sequencing data obtained from 4 longitudinal prostate cancer\ntumour samples from the same patient (patient 498°). The plot below shows\nthe average cancer cell frequency (CCF) for each significant subclone. The\nsamples shown were sampled at three different timepoints, labelled T1, T2\nand T3. The circle size corresponds to the proportion of SVs within the cluster\nvs. the total SVs for the sample." + }, + { + "id": 160986, + "strid": "92353c32-895c-4e23-9e06-602f94cd26c3", + "image_id": 206784, + "image_name": "6425.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1776.726, + 2035.447, + 1384.1799999999998, + 785.8170000000002 + ], + "priority": 14, + "parents": [ + 160974 + ], + "children": [], + "area": 3616431.606522, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 160982, + "strid": "a144e6bb-6ab6-44de-889e-7bd30d8d9e0e", + "image_id": 206784, + "image_name": "6425.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1784.521, + 2902.78, + 1354.1299999999999, + 143.17799999999988 + ], + "priority": 15, + "parents": [ + 160974 + ], + "children": [], + "area": 5180071.86838, + "iscrowd": 0, + "segmentation": [], + "text": "The Circos plots below show the rearrangemenis for each sample, colour-\ncoded based on the average CCF. 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Flowchart illustrating search result compilation" + }, + { + "id": 22864, + "strid": "f399b447-cfdc-4388-9848-b559b8b2c2cf", + "image_id": 201415, + "image_name": "11708.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 37.599, + 549.724, + 239.35500000000002, + 157.45400000000006 + ], + "priority": 13, + "parents": [ + 22854 + ], + "children": [], + "area": 20669.072676, + "iscrowd": 0, + "segmentation": [], + "text": "AN Seawater et\nOur fistappraseh involved tox mining the completeset\nofsearch resultstorspecifictermsinboththetiteand\nabstract together. Fortis we found Endnotes Boolean\nSearen function quite adequate\n\nThis terievalcan be improved by using Endnotes Fine\nFull-text Function and subsequetysearehingthe ties,\nabevarsang ettached >DFsof the fullest stles,\nTherolect thismethadtstwoFola providesthe\ninfermationscientstswitha quickassessmentafthe\neffectiveness of ter search trates.\n\nWe Usedthiemethad a qulcelyidanty tuseswhigh\nwanvailinduigeersii ctoudilsuliradtionsknal" + }, + { + "id": 22865, + "strid": "3afea7b6-605d-4192-9128-c2a3e427fa59", + "image_id": 201415, + "image_name": "11708.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 38.103, + 720.103, + 237.156, + 231.769 + ], + "priority": 14, + "parents": [ + 22854 + ], + "children": [], + "area": 27438.084608999998, + "iscrowd": 0, + "segmentation": [], + "text": "eee eee\nWe perused the references andidentiedthe most\nfrequenttermspresentamngtilesof relevant\nstudies\n\nThese largely fellinto abroadcategories: study setting\nsiceacecf interestand study design Wesearched the\nIterature corpus tor these terme, grouping the results\nthese specifisearcnes separately (Figure). Where\nsimilasermeindicstaielovance|ag. tubercles,\ntuberculoma, tuberculous)» tuncated formafthe word\nwvasusedto search\n\nFach group wasscreened toramove studies whose\nrelevance wasunsure(toavoidexclucingrelavart\nstudies) Thiscycleof perusing andsearchingcontinved\nuntill majorsets of irelevant studies wereidentes,\ncach group was sereenedtoramove anyrelevant\nstudies. Remainingstudes werethen deemed tobe\nirelevantendexcladedTossrastcllyreducedthe\nnumber of titles which required screening," + }, + { + "id": 22870, + "strid": "ad7b1677-e969-46a0-aa92-239929989576", + "image_id": 201415, + "image_name": "11708.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 299.302, + 372.575, + 249.08299999999997, + 208.10200000000003 + ], + "priority": 15, + "parents": [ + 22854 + ], + "children": [ + 22869 + ], + "area": 111512.44265, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 22869, + "strid": "258ccc1a-078a-4a26-88de-28983fa0918b", + "image_id": 201415, + "image_name": "11708.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 300.752, + 356.962, + 224.02400000000006, + 12.446000000000026 + ], + "priority": 16, + "parents": [ + 22870 + ], + "children": [], + "area": 107357.035424, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2. Removal of ineligible titles using text-mining" + }, + { + "id": 22871, + "strid": "27504535-d354-4aeb-b4e8-52a5994e634e", + "image_id": 201415, + "image_name": "11708.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 552.466, + 356.396, + 235.01200000000006, + 206.77100000000002 + ], + "priority": 17, + "parents": [ + 22854 + ], + "children": [], + "area": 196896.672536, + "iscrowd": 0, + "segmentation": [], + "text": "Stelbenk screening Aippatom:\nMany of the studs forwnien ullterscresningwas\nrequiredwerenat excluded curingthatitleand abstract\nsereening tages, simely because the study semIngas\nnot mentioned inthetitlertheabstrect or relevant\ndetaileware ambiguous.\n\nsence, full-tn screaningwasrequied fora spuntously\nlargenumberof articles, inorder to avoidan inflated\nworkload, we decided 1 perfor fulltertscreenngin\nmmultiplestages, the first stage which weuldbeto\nascertain the stady setting thus quickly exci,\nirelavantstudies\n\nOnlythen did we proceed oidentiy whether ornotthe\nanieleweetelevartferinlusionindurreviewarnot\n(Figured), Other eter whichwre used inludedthe\ncondition f eres (pneumonia andthedlseaseot\nidematipnouneriay." + }, + { + "id": 22873, + "strid": "54a1e263-e5e3-4fa6-b18b-f1731bdd280c", + "image_id": 201415, + "image_name": "11708.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 294.871, + 597.856, + 496.049, + 346.48299999999995 + ], + "priority": 18, + "parents": [ + 22854 + ], + "children": [ + 22872 + ], + "area": 176290.396576, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 22872, + "strid": "a6ccdfc7-3e6d-4142-9915-a86701b48852", + "image_id": 201415, + "image_name": "11708.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 296.176, + 599.627, + 159.69099999999997, + 12.636999999999944 + ], + "priority": 19, + "parents": [ + 22873 + ], + "children": [], + "area": 177595.126352, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3, Full-text screening algorithm" + }, + { + "id": 22855, + "strid": "5580a4cc-a038-4468-8b3d-fa908837772f", + "image_id": 201415, + "image_name": "11708.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 28.168, + 953.842, + 77.35499999999999, + 14.734000000000037 + ], + "priority": 20, + "parents": [ + 22875 + ], + "children": [ + 22868, + 22874, + 22867 + ], + "area": 26867.821455999998, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion" + }, + { + "id": 22867, + "strid": "47e175d3-71f3-4203-886c-466419970ffb", + "image_id": 201415, + "image_name": "11708.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 26.83, + 970.296, + 564.187, + 62.55600000000004 + ], + "priority": 21, + "parents": [ + 22855 + ], + "children": [], + "area": 26033.04168, + "iscrowd": 0, + "segmentation": [], + "text": "FRR ale ae Ra pin as eoenra pT rE Aine RiP lL He TNT Op NEO TONS\nto prionrize studies for screening based onthe presence (and relabve absence) ofkey terms anc phrases which ncceterelevace.\nHonvowe, acoasstosuch rescues are limited incesource poor setings,thushighighing the rol of manual ext miningstrateges,\ncuches those presentedhere. A naonstalheath and pneumonia are bethpriortyrecearch areas, wehope that our key terms, phrases\nsi pia Eins lg in schon gis La" + }, + { + "id": 22868, + "strid": "9248e4d3-bc1d-48b3-9c09-6b1272cdca13", + "image_id": 201415, + "image_name": "11708.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 27.356, + 1049.843, + 539.456, + 39.759000000000015 + ], + "priority": 22, + "parents": [ + 22855 + ], + "children": [], + "area": 28719.505108000005, + "iscrowd": 0, + "segmentation": [], + "text": "ie aie Ga eB har NS PLES VILE NESE II EAN ay OOGE\nPP1084207) to The INCLEN Trust Intemational and sub-grant te Manipal University (subgrantINC201SGNTOO4). Publi\nHealth Evidence South Asia (PHESA), the Manipal University for necessary institutional and infrastructural support." + }, + { + "id": 22874, + "strid": "654dd299-9257-4430-81f7-2b69f6d5954f", + "image_id": 201415, + "image_name": "11708.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 600.001, + 959.369, + 195.91100000000006, + 132.00799999999992 + ], + "priority": 23, + "parents": [ + 22855 + ], + "children": [], + "area": 575622.359369, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190465, + "strid": "39609f7b-d1bf-41fa-8c5a-aa0af747eb42", + "image_id": 207934, + "image_name": "9141.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 332.24, + 61.3, + 139.70999999999998, + 256.14 + ], + "priority": -1, + "parents": [], + "children": [ + 190459, + 190462, + 190464, + 190461, + 190463, + 190458, + 190460 + ], + "area": 20366.311999999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190458, + "strid": "ea875cca-1a17-4f9b-b70b-06dd07c43e99", + "image_id": 207934, + "image_name": "9141.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 526.692, + 83.167, + 2515.574, + 353.951 + ], + "priority": 1, + "parents": [ + 190465 + ], + "children": [], + "area": 43803.393564, + "iscrowd": 0, + "segmentation": [], + "text": "RELATION BETWEEN STATUS OF SECOND-HAND\nSMOKER WITH HYPERTENSION IN HOUSEWIVES\nAT RURAL AREAS IN MALANG, INDONESIA" + }, + { + "id": 190459, + "strid": "aeea2fd1-b2d9-479d-b643-cdf5ee901f9f", + "image_id": 207934, + "image_name": "9141.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 243.832, + 479.756, + 3041.187, + 392.712 + ], + "priority": 2, + "parents": [ + 190465 + ], + "children": [], + "area": 116979.86499199999, + "iscrowd": 0, + "segmentation": [], + "text": "Ricardo Adrian Nugraha', Michael Jonatan', Gurid Anggridiaksha', Kinanthi Koesandrini', Devianty Octavia', Nur Syahadati\nPanenggak’, Wilbert Sudihardjo', Firas Farisi Alkaff ', Sirazul Munir?, Subur Prayitno®, Diohar Nuswantoro?\n' Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Hospital, Surabaya, Indonesia\n2 Murnajati Public Health Institute Lawang- Provincial Government in East Java, Indonesia\n3Public Health Department - Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia\nCorrespondence email: ricardo.unair@ gmail.com" + }, + { + "id": 190461, + "strid": "73fd4020-376d-4a41-b0cb-6bd2bcd7154e", + "image_id": 207934, + "image_name": "9141.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 121.242, + 918.674, + 1439.674, + 2302.414 + ], + "priority": 3, + "parents": [ + 190465 + ], + "children": [], + "area": 111381.873108, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190460, + "strid": "54db8c18-ffcc-478a-a23a-87ae2bd15526", + "image_id": 207934, + "image_name": "9141.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1649.624, + 967.563, + 1802.6500000000003, + 2123.186 + ], + "priority": 4, + "parents": [ + 190465 + ], + "children": [], + "area": 1596115.146312, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction. National health survey reported more than 50%\nhousewives are second-hand smokers. Many studies proved a strong\ncorrelation between tobacco exposure among active smoker with\nincidence of hypertension and cardiovascular diseases. However, to our\nknowledge, epidemiological evidence regarding the relationship between\nstatus of second-hand smoker and case of hypertension has not been\nsummarized\n\nObjective. To understand relationship between status of second-hand\nsmoker with case/disease of hypertension in housewives aged 40-55\nyears at rural area in Dusun Gondang Desa Randuagung Kecamatan\nSingosari Kabupaten Malang.\n\nMethods. Analytic observational epidemiological study with cross-\nsectional design, using status of second-hand smoker as a risk factor for\nhypertension. Population are housewives aged 40-55 years in RW 5\nDusun Gondang Desa Randuagung Kecamatan Singosari Kabupaten\n\nalang. Menopause, history of antihypertensive medication, or pregnant\n\nubjects were excluded. Then, we randomized total population to get 66\nsubjects using Simple Random Sampling. Data were obtained from free-\nguided interview about exposure to tobacco smoke inside the house and\nbasal blood le) gexctsiu a=) measurement using standardized\nsphygmomanometer.\n\nResults. From 66 subjects, 29 (43,9%) aged 40-44 years, 13 (19,7%)\naged 45-49 years, and 24 (36,4%) aged 50-55 years. Total subjects who\nwere exposed to tobacco smoke or second-hand smoker were 36\n(54,54%), and number of hypertension are 33 (50,00%) among total\nsubjects. Number of hypertension among second-hand smokers group\nwere significantly higher (p<0,0001). Compared with non-exposed\nsvblectoammags (95% Cl) accross second-hand smoker were 4,667\n(2,05" + }, + { + "id": 190462, + "strid": "8fc17027-4bf1-4156-ae39-feb5aa3c3504", + "image_id": 207934, + "image_name": "9141.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 85.163, + 3294.661, + 884.614, + 792.462 + ], + "priority": 5, + "parents": [ + 190465 + ], + "children": [], + "area": 280583.214743, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190463, + "strid": "1cbf4b5c-1108-4b0d-bb8d-642aa2148c18", + "image_id": 207934, + "image_name": "9141.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1741.09, + 3324.841, + 1719.1250000000002, + 866.2819999999997 + ], + "priority": 6, + "parents": [ + 190465 + ], + "children": [], + "area": 5788847.416689999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190464, + "strid": "27cbda89-0a31-4546-8afc-37adc7c59635", + "image_id": 207934, + "image_name": "9141.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 89.143, + 4254.698, + 3316.393, + 408.60199999999986 + ], + "priority": 7, + "parents": [ + 190465 + ], + "children": [], + "area": 379276.54381400003, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion. Status of second-hand smoker is one of the risk factor for hypertension. Future research with\nprospective cohort study, bigger, and more heterogeneous population are needed to understand further\nabout status of second-hand smoker with case of hypertension.\n\nKeywords: Environmental Tobacco Smoke, Housewive, Hypertension, Rural District, Second-hand Smoker" + }, + { + "id": 91901, + "strid": "4db816ae-807c-48f5-95fb-f86735860595", + "image_id": 204064, + "image_name": "121400.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 72.67, + 95.02, + 146.87, + 140.48000000000002 + ], + "priority": -1, + "parents": [], + "children": [ + 91883, + 91884, + 91886, + 91882, + 91881, + 91885 + ], + "area": 6905.1034, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 91881, + "strid": "659d376f-78db-4363-8097-c0da2f643b25", + "image_id": 204064, + "image_name": "121400.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 291.287, + 206.429, + 3318.021, + 259.4390000000001 + ], + "priority": 1, + "parents": [ + 91901 + ], + "children": [], + "area": 60130.08412299999, + "iscrowd": 0, + "segmentation": [], + "text": "Phase | trial of active specific immunotherapy with autologous dendritic\ncells pulsed with autologous irradiated tumor stem cells in hepatitis B\npositive patients with hepatocellular carcinoma" + }, + { + "id": 91882, + "strid": "1cc60f8b-8345-4ba4-8b83-8a1426e66744", + "image_id": 204064, + "image_name": "121400.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 138.004, + 527.323, + 3429.661, + 312.58000000000004 + ], + "priority": 2, + "parents": [ + 91901 + ], + "children": [], + "area": 72772.68329199999, + "iscrowd": 0, + "segmentation": [], + "text": "Michael E. Bayer MD\", Xiaojin Wang MD’, Xiaosong Chen MD®°, Qingchun Fu MD2, Craig Fredrickson BS', Jessica Cannon BS’, Greg Liang MD\",\nJia He MD, PhD‘, Jia Liu MD5, Wei Cao PhD*, Andrew N. Cornforth PhD’, Gabriel | Nistor MD’, Chengwei Chen MD2, Robert O. Dillman MD'\n\n'NeoStem, Inc., New York, NY, USA; “Hospital 85 People’s Liberation Army of China, Shanghai, China; 3Shanghai Renji Hospital, Shanghai, China;\n4Second Military Medical University of China, Shanghai, China; °Cellular Biomedicine Group, Shanghai, China\n*These authors contributed equally to this work" + }, + { + "id": 91883, + "strid": "02c805ff-a39c-4e98-9a72-244464d62f61", + "image_id": 204064, + "image_name": "121400.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 780.392, + 921.716, + 408.374, + 55.960000000000036 + ], + "priority": 3, + "parents": [ + 91901 + ], + "children": [ + 91888, + 91887 + ], + "area": 719299.792672, + "iscrowd": 0, + "segmentation": [], + "text": "Background" + }, + { + "id": 91887, + "strid": "69a5b1d1-8409-4543-a5f9-e33f4456cb8c", + "image_id": 204064, + "image_name": "121400.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 84.525, + 1028.426, + 1261.088, + 213.4760000000001 + ], + "priority": 4, + 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This study shows sufficient safety to justify a Phase Il efficacy trial in similar patients." + }, + { + "id": 154379, + "strid": "79c7fe56-f24e-4136-9e42-761710bb542d", + "image_id": 206518, + "image_name": "22574.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 60.02, + 48.05, + 542.76, + 51.09 + ], + "priority": -1, + "parents": [], + "children": [ + 154352, + 154355, + 154356, + 154362, + 154354, + 154353 + ], + "area": 2883.961, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 154352, + "strid": "090c423a-da56-4ca7-9205-b3461d1f060d", + "image_id": 206518, + "image_name": "22574.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 114.318, + 132.319, + 1115.268, + 613.966 + ], + "priority": 1, + "parents": [ + 154379 + ], + "children": [], + "area": 15126.443441999998, + "iscrowd": 0, + "segmentation": [], + "text": "Two years of\nthe ELIXIR-UK\nFellowship\n\nEmpowering Minds: Professionalising\nUK Data Stewardship in Life Sciences" + }, + { + "id": 154353, + "strid": "9d71a288-06c9-4500-b34b-fb65a06e7cab", + "image_id": 206518, + "image_name": "22574.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 118.859, + 792.488, + 1163.984, + 177.327 + ], + "priority": 2, + "parents": [ + 154379 + ], + "children": [], + "area": 94194.331192, + "iscrowd": 0, + "segmentation": [], + "text": "Kamieniecka, Katarzyna’; Perez-Sitja, Xenia’; Delva, Emily, Knox, Catherine®: Andrabi,\nMunazah*; Juty, Nick’; Sufi, Shoaib?; Sansone, Susanna-Assunta‘; Goble, Carole’; Andrews,\nRobert? and Poterlowicz, Krzysztof*\n\n1: University of Bradford, UK; 2: University of Cardiff, UK; 3: University of Manchester, UK; 4: University\nof Oxford, UK; 5: Earlham Institute, UK" + }, + { + "id": 154354, + "strid": "6af3568b-0020-43bd-b9ee-f3b09cc8a41e", + "image_id": 206518, + "image_name": "22574.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 117.468, + 1135.198, + 987.8080000000001, + 68.16499999999996 + ], + "priority": 3, + "parents": [ + 154379 + ], + "children": [ + 154359, + 154358, + 154357, + 154360 + ], + "area": 133349.43866400002, + "iscrowd": 0, + "segmentation": [], + "text": "The project behind the Fellowship" + }, + { + "id": 154358, + "strid": "97c33ed4-0e6b-44ef-b7a0-fd3625baf9e2", + "image_id": 206518, + "image_name": "22574.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 117.85, + 1233.646, + 1151.147, + 100.61400000000003 + ], + "priority": 4, + "parents": [ + 154354 + ], + "children": [], + "area": 145385.1811, + "iscrowd": 0, + "segmentation": [], + "text": "In 2021, ELIXIR-UK was granted a UKRI award for the ELIXIR-UK DaSH project. The University\nof Bradford leads the project with a delivery team at Cardiff University, the Earlham Institute,\nthe University of Manchester, and the University of Oxford." + }, + { + "id": 154359, + "strid": "b25b7132-802a-46a8-beb4-f8c7b19de9f3", + "image_id": 206518, + "image_name": "22574.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 116.371, + 1512.336, + 1140.79, + 133.60500000000002 + ], + "priority": 5, + "parents": [ + 154354 + ], + "children": [], + "area": 175992.05265599999, + "iscrowd": 0, + "segmentation": [], + "text": "The project aims to embed Research Data Management (RDM) know-how into UK universities\nand institutes by producing and delivering training in Data Stewardship. It focuses on building\ncapacity and professionalising the role of Data Stewards while leveraging the local expertise\nwithin diverse UK research-performing organisations." + }, + { + "id": 154360, + "strid": "9699fdf2-9cac-491e-90dd-aa11d5544008", + "image_id": 206518, + "image_name": "22574.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 117.85, + 1726.402, + 1103.279, + 135.56400000000008 + ], + "priority": 6, + "parents": [ + 154354 + ], + "children": [], + "area": 203456.47569999998, + "iscrowd": 0, + "segmentation": [], + "text": "Ultimately, the project aims to create a culture change witha\nFellowship of Data Stewards. Fellows will act as ambassadors to\nembed RDM for the life sciences in their organisations." + }, + { + "id": 154357, + "strid": "7546d037-8e4a-474f-ba34-5ec48b2c1d10", + "image_id": 206518, + "image_name": "22574.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 22.136, + 1436.689, + 1330.415, + 2920.0199999999995 + ], + "priority": 7, + "parents": [ + 154354 + ], + "children": [], + "area": 31802.547704, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 154355, + "strid": "aac17409-8448-4d34-9c56-cbf3e866d5b7", + "image_id": 206518, + "image_name": "22574.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1509.318, + 128.797, + 1545.8750000000002, + 67.57300000000001 + ], + "priority": 8, + "parents": [ + 154379 + ], + "children": [], + "area": 194395.630446, + "iscrowd": 0, + "segmentation": [], + "text": "Reasons to apply vs the benefits current Fellows have" + }, + { + "id": 154362, + "strid": "024bc786-47ae-45a7-9faa-a29337703c5d", + "image_id": 206518, + "image_name": "22574.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1508.283, + 201.547, + 362.2069999999999, + 66.37300000000002 + ], + "priority": 9, + "parents": [ + 154379 + ], + "children": [ + 154361, + 154363, + 154368, + 154364, + 154372, + 154369, + 154371, + 154366, + 154367, + 154370, + 154365 + ], + "area": 303989.913801, + "iscrowd": 0, + "segmentation": [], + "text": "experienced" + }, + { + "id": 154363, + "strid": "d7143f6e-3d14-468e-9d37-39d33e476d83", + "image_id": 206518, + "image_name": "22574.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1510.193, + 301.223, + 691.9860000000001, + 164.902 + ], + "priority": 10, + "parents": [ + 154362 + ], + "children": [], + "area": 454904.866039, + "iscrowd": 0, + "segmentation": [], + "text": "Recently, we've explored the reasons to apply and the\nbenefits that Fellows are experiencing as part of the\nprogramme. This data will help sustain the Fellowship for\nfuture rounds and enhance the offer to meet the needs of\ncurrent and prospective Fellows." + }, + { + "id": 154364, + "strid": "ab1ffdb2-e2fe-45bb-9a30-34face1e0d62", + "image_id": 206518, + "image_name": "22574.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1508.005, + 486.935, + 332.28099999999995, + 118.47399999999999 + ], + "priority": 11, + "parents": [ + 154362 + ], + "children": [], + "area": 734300.414675, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 154365, + "strid": "43c6519e-1e7d-440d-b426-6517b0f35601", + "image_id": 206518, + "image_name": "22574.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1507.549, + 688.075, + 718.4539999999997, + 407.509 + ], + "priority": 12, + "parents": [ + 154362 + ], + "children": [], + "area": 1037306.7781750001, + "iscrowd": 0, + "segmentation": [], + "text": "Unexpected benefits\n\nCreating resources and training\nmaterials\n\nBeing part of the Fellowship entails creating and organising\ntraining courses, developing guidelines, and contributing\n\nto ELIXIR resources such as the RDMkit, FAIRCookbook,\nTeSS, FAIRsharing or the Data Stewardship Wizard. Fellows\nhave stated they are interested in creating together\n“publicly accessible content to stop remaking the wheel.”" + }, + { + "id": 154361, + "strid": "f3851778-60ca-4266-b093-28985c7a41d3", + "image_id": 206518, + "image_name": "22574.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2231.051, + 236.249, + 1014.9990000000003, + 857.2439999999999 + ], + "priority": 13, + "parents": [ + 154362 + ], + "children": [], + "area": 527083.567699, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 154366, + "strid": "66b1b482-7b29-445f-a910-cbfa7c9e187e", + "image_id": 206518, + "image_name": "22574.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1509.091, + 1217.025, + 776.3229999999999, + 96.16699999999992 + ], + "priority": 14, + "parents": [ + 154362 + ], + "children": [], + "area": 1836601.474275, + "iscrowd": 0, + "segmentation": [], + "text": "Despite not being vital for applicants, Fellows have shown a\nstrong interest and motivation to contribute to key international\nresources and create materials to build capacity in RDM locally." + }, + { + "id": 154368, + "strid": "6b18f6dc-0762-4d34-b43f-19c0ae841794", + "image_id": 206518, + "image_name": "22574.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1508.47, + 1371.876, + 800.4590000000001, + 352.5730000000001 + ], + "priority": 15, + "parents": [ + 154362 + ], + "children": [], + "area": 2069433.78972, + "iscrowd": 0, + "segmentation": [], + "text": "Gaining and improving training skills\n\nOne of the Fellowship’s key benefits is the ELIXIR Train the Trainer\n(TtT). Delivered at the start of the programme, it brings the\nexpertise of several ELIXIR members not only in the UK but across\nother Nodes. The TtT was attended by nearly 90% of all Fellows,\neven those with a background in academic education.\n\nWhile this aspect was not particularly important for candidates\nto apply, it was observed as a significant impact that Fellows have\nexperienced." + }, + { + "id": 154369, + "strid": "0c90e2fb-909b-4788-9816-c3eb3d903632", + "image_id": 206518, + "image_name": "22574.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1508.595, + 1783.738, + 816.242, + 255.10899999999992 + ], + "priority": 16, + "parents": [ + 154362 + ], + "children": [], + "area": 2690938.22811, + "iscrowd": 0, + "segmentation": [], + "text": "Mentorship\n\nIn January 2023, we announced our mentorship programme, a new\nfeature of the Fellowship, providing advice in specific RDM domains\nand pedagogical best practices. This new benefit was unavailable\nfor Fellows in both cohorts at the beginning of their programmes.\nWe decided to start it after our experience supporting the first\ncohort." + }, + { + "id": 154371, + "strid": "d09d4404-9e5c-4117-9543-5c09c30aed70", + "image_id": 206518, + "image_name": "22574.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1507.493, + 2138.062, + 815.1210000000001, + 735.5070000000001 + ], + "priority": 17, + "parents": [ + 154362 + ], + "children": [], + "area": 3223113.498566, + "iscrowd": 0, + "segmentation": [], + "text": "Benefits we delivered beyond\nexpectations\n\nNetworking and community\n\nSSI’s experience in community engagement SOFTWARE\nhas paved the way to building a sense of (@) Bre cea\ncommunity, mentoring and advising the\n\ncoordination team with more than ten years of\n\nexperience managing the successful SSI Fellowship.\n\n \n\nAs aresult, we've exceeded expectations in this arena. Networking\nwas the second most important reason to apply, and we delivered\nbeyond Fellows’ expectations. We've offered drop-in sessions,\ncommunity calls, ELIXIR-UK mentors, ELIXIR-UK working groups,\nin-person retreats or event sponsorship for events like the ELIXIR\nAll Hands.\n\nIn addition, some Fellows are already getting involved in the ELIXIR\nRDM Community, a hub for know-how exchange and development\nof training in RDM." + }, + { + "id": 154367, + "strid": "043dddd2-4867-487a-a0ae-bf57074e0aa3", + "image_id": 206518, + "image_name": "22574.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2419.603, + 1184.772, + 790.5830000000001, + 771.2539999999999 + ], + "priority": 18, + "parents": [ + 154362 + ], + "children": [], + "area": 2866677.885516, + "iscrowd": 0, + "segmentation": [], + "text": "Benefits with room for\nimprovement\n\nBadge of recognition\n\nWhile we welcome professionals who work with data in the\n\nlife sciences at any career stage, a panel of experts scrutinises\napplications. All candidates must not only demonstrate a strong\nunderstanding of data management in their fields, but have\nexcellent communication and team working skills. Only some can\npass this thorough selection process, already recognising Fellows’\nskills and experience.\n\nSome Fellows from the first cohort have already experienced\n\nthe benefit of holding the ELIXIR-UK badge of recognition when\ndiscussing RDM at their organisations. After being selected, they\nhad a stronger voice in meetings, a motto we have adopted in our\noutreach: “Trust me, I’m an ELIXIR-UK Fellow.”\n\nHowever, we still have room for improvement to elevate Fellows’\nwork and stories. For instance, we plan on showcasing their\nsuccesses through official ELIXIR-UK channels more prominently." + }, + { + "id": 154370, + "strid": "6d8ec30d-28f6-4f07-a49f-4db900fb0caa", + "image_id": 206518, + "image_name": "22574.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2420.239, + 2014.771, + 761.9749999999999, + 252.885 + ], + "priority": 19, + "parents": [ + 154362 + ], + "children": [], + "area": 4876227.350269, + "iscrowd": 0, + "segmentation": [], + "text": "Career development\n\nWhile this benefit has been one of the main drivers to apply, we\ncannot expect to reap the benefits in less than two years.\n\nNevertheless, we've already observed two Fellows that have\nbenefited from being part of the programme in their career\nprogress with recent promotions and PhD opportunities." + }, + { + "id": 154372, + "strid": "d26210f3-89c8-4c51-8e87-cbf60f64d7ca", + "image_id": 206518, + "image_name": "22574.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2418.881, + 2324.829, + 810.435, + 420.13200000000006 + ], + "priority": 20, + "parents": [ + 154362 + ], + "children": [], + "area": 5623484.696349001, + "iscrowd": 0, + "segmentation": [], + "text": "Financial support\n\nWe are aware of the current struggles for professionals in research\nand academia taking on activities without financial reward or\nindependence. We, therefore, offer small honorariums for Fellows’\ntime invested in the activities of this Fellowship.\n\nAlthough it may seem we are not delivering as expected in this\narea, we are on track. Fellows only receive their honorariums\n\nafter completing their tasks. We expect most of our community to\nbenefit significantly in this area by June 2023, after attending and\nreporting on several conferences and meetings, and delivering new\npieces of training." + }, + { + "id": 154356, + "strid": "6425cd62-83b2-4a7b-849d-25ff39335fcd", + "image_id": 206518, + "image_name": "22574.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1505.777, + 2989.733, + 353.83500000000004, + 58.38799999999992 + ], + "priority": 21, + "parents": [ + 154379 + ], + "children": [ + 154378, + 154376, + 154374, + 154377, + 154373, + 154375 + ], + "area": 4501871.187541001, + "iscrowd": 0, + "segmentation": [], + "text": "What’s new" + }, + { + "id": 154373, + "strid": "2dbb69d1-dac6-4f67-bd83-5cd3dc470e27", + "image_id": 206518, + "image_name": "22574.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1506.078, + 3072.5, + 764.1749999999997, + 201.19799999999987 + ], + "priority": 22, + "parents": [ + 154356 + ], + "children": [], + "area": 4627424.655, + "iscrowd": 0, + "segmentation": [], + "text": "Started a mentorship scheme\n\nIn 2023, we recruited 12 mentors from our pool of ELIXIR-UK\nexperts to help Fellows create their training materials. Mentors\nprovide not only advice in specific RDM domains but also\npedagogical best practices." + }, + { + "id": 154378, + "strid": "bcccf8c7-d20f-419c-bd64-7a0e9b0f1969", + "image_id": 206518, + "image_name": "22574.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1503.301, + 3286.301, + 810.0, + 711.3200000000002 + ], + "priority": 23, + "parents": [ + 154356 + ], + "children": [], + "area": 4940299.579601, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 154376, + "strid": "5b4fb0c6-2c53-463e-8789-e5567317ea49", + "image_id": 206518, + "image_name": "22574.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1506.952, + 4095.399, + 808.2050000000002, + 425.7329999999997 + ], + "priority": 24, + "parents": [ + 154356 + ], + "children": [], + "area": 6171569.713847999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 154374, + "strid": "8eb8bf04-1043-490e-95ad-46743f8c1e37", + "image_id": 206518, + "image_name": "22574.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2415.271, + 3073.645, + 804.9769999999999, + 200.28499999999985 + ], + "priority": 25, + "parents": [ + 154356 + ], + "children": [], + "area": 7423685.632795, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 154375, + "strid": "ada8db45-e6fd-4c7b-bd79-e16f6ef91459", + "image_id": 206518, + "image_name": "22574.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2416.431, + 3352.296, + 803.855, + 353.76099999999997 + ], + "priority": 26, + "parents": [ + 154356 + ], + "children": [], + "area": 8100591.975575999, + "iscrowd": 0, + "segmentation": [], + "text": "Launched an official Fellowship\nwebsite\n\nThe Fellowship now has a GitHub-hosted website using the ELIXIR\nToolkit Jekyll theme. We aim to use bioschemas markup across the\nsite so that materials and events automatically appear on TeSS.\n\nThe site aims to recognise Fellows and Mentors that contributed\nto resources, training and events, and assist in communicating our\nwork and sharing resources at Fellows’ organisations." + }, + { + "id": 154377, + "strid": "3bff8ffa-f115-4bdb-9026-ef7e90290e94", + "image_id": 206518, + "image_name": "22574.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2419.177, + 4008.051, + 811.5, + 520.7900000000004 + ], + "priority": 27, + "parents": [ + 154356 + ], + "children": [], + "area": 9696184.794027, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 80450, + "strid": "d0631c3d-75ca-461c-af6b-7b838b5210a0", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 264.14, + 21.72, + 405.41999999999996, + 110.03999999999999 + ], + "priority": -1, + "parents": [], + "children": [ + 80407, + 80402, + 80446, + 80426, + 80403, + 80412, + 80404, + 80408, + 80406, + 80431, + 80432, + 80443, + 80415 + ], + "area": 5737.1208, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 80402, + "strid": "78582aa8-f4f6-4a80-9e52-37a8b779898e", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 244.721, + 195.528, + 3309.996, + 214.593 + ], + "priority": 1, + "parents": [ + 80450 + ], + "children": [], + "area": 47849.807688, + "iscrowd": 0, + "segmentation": [], + "text": "Quantifying abiotic:habitat characteristics to determine\nthresholds for salmonid over-summer Survival in intermittent streams" + }, + { + "id": 80403, + "strid": "80ac06c5-3795-470f-8fc9-846383154ee6", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 243.346, + 448.761, + 1902.158, + 87.40799999999996 + ], + "priority": 2, + "parents": [ + 80450 + ], + "children": [], + "area": 109204.194306, + "iscrowd": 0, + "segmentation": [], + "text": "Cleo Woelfle-Erskine', Jan Hildebrand’, Laurel L. Larsen”, Stephanie.M. Carlson®\n\n‘ Energy and Resources group, UC Berkeley ? Department of Geography, UC Berkeley, * Department of Environmental Sciences, Policy, and Management, UC Berkeley" + }, + { + "id": 80407, + "strid": "b726f4a3-4508-48c1-934f-f91814d7f09a", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 230.303, + 603.653, + 867.852, + 500.39300000000003 + ], + "priority": 3, + "parents": [ + 80450 + ], + "children": [ + 80405 + ], + "area": 139023.096859, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 80405, + "strid": "420ece72-4677-4097-9b66-1c3d7f1c14b9", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 222.737, + 1150.518, + 115.64099999999999, + 29.18100000000004 + ], + "priority": 4, + "parents": [ + 80407 + ], + "children": [], + "area": 256262.927766, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1" + }, + { + "id": 80406, + "strid": "2a88b845-bbf2-47e4-8a62-8a54cef679b2", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 225.979, + 1185.102, + 390.155, + 211.82899999999995 + ], + "priority": 5, + "parents": [ + 80450 + ], + "children": [], + "area": 267808.16485800006, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 80404, + "strid": "9184b1eb-30a3-401a-acde-0d89f96a8e0c", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 647.477, + 1115.934, + 455.0010000000001, + 368.53999999999996 + ], + "priority": 6, + "parents": [ + 80450 + ], + "children": [], + "area": 722541.598518, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 80412, + "strid": "1a5623e8-bbb0-474e-a0d1-20a1a95f9cde", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 247.764, + 1497.968, + 369.4440000000001, + 55.58999999999992 + ], + "priority": 7, + "parents": [ + 80450 + ], + "children": [ + 80451, + 80413, + 80411 + ], + "area": 371142.543552, + "iscrowd": 0, + "segmentation": [], + "text": "Study overview" + }, + { + "id": 80411, + "strid": "4d11d9ea-5a35-4691-ab1e-d96ead77a255", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 245.242, + 1561.638, + 862.769, + 400.92700000000013 + ], + "priority": 8, + "parents": [ + 80412 + ], + "children": [], + "area": 382979.22639599995, + "iscrowd": 0, + "segmentation": [], + "text": "Our research investigates thresholds for salmonid over-summer\nsurvival in intermittent streams and the*hydrologic and biogeo-\nchemical conditions in sanctuary reaches where salmonids sur-\nvive. We assess abiotic habitat Characteristics (pool depth and\nvolume, dissolved oxygen (DO), temperature, pH, conductivity,\nand dissolved organic carbon’ (DOC) quality) and salmonid\nover-summer survival infour study reaches on adjacent tributar-\nies to Salmon Creek (Sonoma Co., CA) (Figure 2). The tributar-\nies are similar in area and aspect, but differ in geology and land\ncover; as a result, Fay Creek is intermittent earlier in the\nsummer than Tannery Creek, which flows more continuously." + }, + { + "id": 80451, + "strid": "1c477b36-fc7f-44b7-b437-a6937eaddafc", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 247.379, + 2017.775, + 418.85699999999997, + 272.16100000000006 + ], + "priority": 9, + "parents": [ + 80412 + ], + "children": [ + 80414, + 80452 + ], + "area": 499155.161725, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 80452, + "strid": "a43cb477-d970-4c28-a13f-5d6c8e4afa2a", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 247.999, + 1985.19, + 110.21099999999998, + 32.750999999999976 + ], + "priority": 10, + "parents": [ + 80451 + ], + "children": [], + "area": 492325.13481, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2" + }, + { + "id": 80414, + "strid": "e119104c-63b6-4982-a32e-3be0281c6a8d", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 240.623, + 2298.622, + 800.075, + 68.52300000000014 + ], + "priority": 11, + "parents": [ + 80451 + ], + "children": [], + "area": 553101.3215059999, + "iscrowd": 0, + "segmentation": [], + "text": "left: Measuring length and width for volumetric calculations.\nright: Seining for juvenile salmonids on Tannery Creek." + }, + { + "id": 80413, + "strid": "f53ee568-4b47-4ec3-8f67-42cf1d82eee1", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 704.84, + 2017.775, + 393.764, + 275.05600000000004 + ], + "priority": 12, + "parents": [ + 80412 + ], + "children": [], + "area": 1422208.5310000002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 80415, + "strid": "456c09c4-0b91-4d45-9e21-d891264ef502", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 246.413, + 2398.028, + 206.53300000000002, + 51.15099999999984 + ], + "priority": 13, + "parents": [ + 80450 + ], + "children": [ + 80417, + 80416 + ], + "area": 590905.273564, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 80416, + "strid": "e6a32a84-3cb2-4a9b-81b0-585457c86343", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 244.483, + 2459.795, + 857.017, + 419.8220000000001 + ], + "priority": 14, + "parents": [ + 80415 + ], + "children": [], + "area": 601378.060985, + "iscrowd": 0, + "segmentation": [], + "text": "1. Salmonid over-summer survival\n\nWe assessed over-summer survival with,paired snorkel surveys\nalong Fay and Tannery creeks in 2012/and 2013 (2014 surveys\nare in progress). The first survey, conducted in July after riffles\nbecame impassible to salmonids, Measured recruitment while\nthe October survey, conductedjust before fall rains, assessed\nover-summer survival. We.attributed the difference between\nJuly and October counts tomortality as fish could not move be-\ntween pools. To assess.snorkel survey accuracy, we compared\nsnorkeled countsito those obtained from seining a subset of the\nsame pools in 2013:and 2014 (Figure 2)." + }, + { + "id": 80417, + "strid": "95764335-5e4f-4806-877d-7fbbde703e23", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 245.448, + 2889.269, + 856.052, + 671.7159999999999 + ], + "priority": 15, + "parents": [ + 80415 + ], + "children": [], + "area": 709165.297512, + "iscrowd": 0, + "segmentation": [], + "text": "2. Abiotic characteristics\n\nWe measuredwater quality with a YSI sonde at four points per\npool at monthly intervals during the study period, May-October.\nWe.also measured DO continuously at one isolated pool on Fay\nCreek in 2013 and at three isolated pools in 2014. In 2012 we\nmeasured pool length, 5 pool widths, and 20 pool depths manu-\nally (Figure 2), while in 2013 we surveyed pool topography with\na total station and terrestrial laser scanner and measured water\ndepth at monthly intervals with a staff gauge. We obtained sam-\nples for dissolved organic carbon analyses at monthly intervals\nfrom 20 piezometers and surface water in the study reaches\nand from private wells and springs distributed throughout the\nwatersheds. We determined DOC quality by SUVA (specific UV\nabsorbance at 254 nm) and fluorescence index/We calculated\nstream metabolism rates using the single station’ method. In\npools instrumented with DO sensors, we (compared changing\nDOC quality during the summer months to changes in DO con-\ncentrations and stream metabolism." + }, + { + "id": 80408, + "strid": "1d37ac5e-87eb-49fb-8cd3-7ddba3f8b23b", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1298.095, + 593.926, + 293.96699999999987, + 51.87699999999995 + ], + "priority": 16, + "parents": [ + 80450 + ], + "children": [ + 80409, + 80410 + ], + "area": 770972.37097, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 80409, + "strid": "67951c00-c279-46ef-9b85-9ad152d811f4", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1297.024, + 658.286, + 800.991, + 694.7799999999999 + ], + "priority": 17, + "parents": [ + 80408 + ], + "children": [], + "area": 853812.7408639998, + "iscrowd": 0, + "segmentation": [], + "text": "In coastal California, legacy,resource extraction and ongo-\ning water diversions have “precipitated impending coho\nsalmon (Oncorhynchus kisutch) local extinction and steel-\nhead (O. mykiss) decline. Whereas Native Californian’s\nland management practices had sustained floodplain wet-\nlands and protected’ spring fed tributaries, settler activi-\nties—from beaver extirpation, forestry, road-building, and\nagriculture; to residential development—promoted stream\nincision, mobilized fine sediment, and diverted summer\nspring\\flow from salmonid rearing habitat. Stream reaches\nthat once flowed year round now flow intermittently, drying\ninto a series of disconnected pools during the late summer;\nintermittent reaches now dry completely in drought years.\nThus, understanding how human water diversions affect\nstreamflow and how stream intermittency influences abiotic\nhabitat conditions is critical to averting salmonid extinction\nand recovering self-sustaining runs.\n\nFlow regime and geomorphic setting determine when, jf\never, flow over riffles ceases and astream becomes" + }, + { + "id": 80410, + "strid": "3c06a8d6-6f65-4a83-b58b-3473c6bfd339", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2144.844, + 590.886, + 812.8910000000001, + 739.5889999999999 + ], + "priority": 18, + "parents": [ + 80408 + ], + "children": [], + "area": 1267358.291784, + "iscrowd": 0, + "segmentation": [], + "text": "intermittent. Given the same discharge, asbedrock stream\nwill flow continuously longer than an‘alluvial stream. Flow\ndrives invertebrate drift, temperatufe.re, and dissolved\noxygen mixing, and thus strongly,influences salmonid ener-\ngetic requirements and growth rates. Stream diversions\nreduce hyporheic flow in intermittent streams, causing ex-\nceedence of temperaturevand oxygen thresholds. Nonethe-\nless, intermittent streams often contribute significantly to ju-\nvenile salmonid rearing) because (1) lower gradients allow\nspawning adults.acceSs over a wider range of flows, (2)\ntheir alluvial setting’allows large pools to form and drives\nhigh primary and secondary productivity. Intermittent\nstreams can contribute to the stability of a population com-\nplex via the portfolio effect and should not be written off in\nsalmonid’recovery planning. Rather, salmonid recovery and\nstream restoration strategies should target “sanctuary\nreaches” that possess adequate flow and structural com-\nplexity to support summer rearing and consider augmenting\nlate-season groundwater flow through conservation and tar-\ngeted aquifer recharge." + }, + { + "id": 80426, + "strid": "d2ea70e6-aeb7-426c-9c6a-cd4cd36eca9c", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1298.017, + 1406.998, + 1084.1590000000003, + 54.0 + ], + "priority": 19, + "parents": [ + 80450 + ], + "children": [ + 80427, + 80420, + 80421, + 80430, + 80418, + 80429, + 80424, + 80428, + 80425, + 80419 + ], + "area": 1826307.322966, + "iscrowd": 0, + "segmentation": [], + "text": "What drives salmonid over-summer survival?" + }, + { + "id": 80424, + "strid": "2f547410-bda1-49d0-93fd-793c1e033494", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1295.248, + 1495.614, + 808.6190000000001, + 605.0799999999999 + ], + "priority": 20, + "parents": [ + 80426 + ], + "children": [], + "area": 1937191.042272, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 80425, + "strid": "f37f72a4-257e-4781-b116-3f1b0b64f0d9", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1291.094, + 2132.54, + 814.1579999999999, + 271.38599999999997 + ], + "priority": 21, + "parents": [ + 80426 + ], + "children": [], + "area": 2753309.59876, + "iscrowd": 0, + "segmentation": [], + "text": "Salmonid recruitment and over-summer survival varies\namong years and reaches and between species. a. Recruit-\nment is less variable on continuous Tannery Creek but higher\nin some years on intermittent Fay Creek. b. In 2012, abun-\ndance varied between pools and by species, and was,lowest\nin isolated pools. c. In 2012, average summer survival was\nhighest in continuous pools on both creeks*yet.remained\nabove 50 % in Fay intermittent and Tannery isolated pools." + }, + { + "id": 80427, + "strid": "a5ca6b47-92d1-4b63-9304-248ff657edcb", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2249.252, + 1483.152, + 622.9769999999999, + 458.807 + ], + "priority": 22, + "parents": [ + 80426 + ], + "children": [], + "area": 3335982.602304, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 80430, + "strid": "ebb9ac5f-1212-43b1-af20-fb796c82b937", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2251.907, + 2016.691, + 622.3379999999997, + 382.25699999999983 + ], + "priority": 23, + "parents": [ + 80426 + ], + "children": [], + "area": 4541400.579737, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 80418, + "strid": "8185ef44-d675-483f-a435-8d0cf6532040", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1297.877, + 2458.692, + 805.406, + 677.8739999999998 + ], + "priority": 24, + "parents": [ + 80426 + ], + "children": [], + "area": 3191079.796884, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 80428, + "strid": "087d8fb4-0ced-4e4c-8682-c5356e3b8150", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2184.665, + 2531.565, + 735.875, + 171.9000000000001 + ], + "priority": 25, + "parents": [ + 80426 + ], + "children": [], + "area": 5530621.450725, + "iscrowd": 0, + "segmentation": [], + "text": "Univariate analysis of salmonid survival\\and abiotic\nhabitat factors shows that juvenile salmonid over-sum-\nmer survival probability correllates\\negatively with\ndays in the intermittent state andypositively with DO,\npool volume, and maximunrdepth." + }, + { + "id": 80429, + "strid": "29283da2-0733-4cee-8f1e-19e4c583c6cd", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2185.842, + 2710.53, + 729.9879999999998, + 367.34900000000016 + ], + "priority": 26, + "parents": [ + 80426 + ], + "children": [], + "area": 5924790.316260001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 80419, + "strid": "e195fcc4-e6e4-4bef-8865-dc0069dce0f5", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1305.919, + 3150.354, + 483.703, + 381.44799999999987 + ], + "priority": 27, + "parents": [ + 80426 + ], + "children": [], + "area": 4114107.145326, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 80420, + "strid": "f0922176-9a4e-4e15-9a09-3912959f437c", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1873.495, + 3161.843, + 475.66100000000006, + 369.9580000000001 + ], + "priority": 28, + "parents": [ + 80426 + ], + "children": [], + "area": 5923697.051285, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 80421, + "strid": "76761cae-c5bf-413d-84e7-387cb33f87aa", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2428.433, + 3156.099, + 469.91600000000017, + 371.10699999999997 + ], + "priority": 29, + "parents": [ + 80426 + ], + "children": [], + "area": 7664374.962867, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 80431, + "strid": "86f9ff65-0016-410e-9219-5c64ca61b7be", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3144.678, + 600.23, + 1275.339, + 65.87800000000004 + ], + "priority": 30, + "parents": [ + 80450 + ], + "children": [ + 80436, + 80433, + 80435, + 80423, + 80442, + 80441, + 80422, + 80438, + 80439, + 80437, + 80440, + 80434 + ], + "area": 1887530.07594, + "iscrowd": 0, + "segmentation": [], + "text": "What abiotic factors characterize sanctuary reaches?" + }, + { + "id": 80436, + "strid": "9dfda05f-b136-4802-8e8e-cae095bc6339", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3171.72, + 741.356, + 660.058, + 640.443 + ], + "priority": 31, + "parents": [ + 80431 + ], + "children": [], + "area": 2351373.65232, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 80435, + "strid": "32c6c899-1a90-4e8a-9345-ddd420df965f", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3184.718, + 1437.053, + 665.9629999999997, + 237.01299999999992 + ], + "priority": 32, + "parents": [ + 80431 + ], + "children": [], + "area": 4576608.556054, + "iscrowd": 0, + "segmentation": [], + "text": "Our four study reaches span a gradient of inter-\nmittency. In 2012, upper Tannery flowed continu-\nously though one side channel pool became, dis-\nconnected; lower Tannery and lower Fay experi-\nenced less than 45 days of disconnection; and all\npools on upper Fay were disconnected.for 40 -100\ndays." + }, + { + "id": 80433, + "strid": "d1a30f84-24e0-479a-827b-202231072764", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3914.66, + 736.193, + 892.7979999999998, + 786.6510000000001 + ], + "priority": 33, + "parents": [ + 80431 + ], + "children": [], + "area": 2881945.28938, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 80434, + "strid": "f5870291-6f4a-4694-bc4d-0774b8cfde47", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3913.206, + 1560.649, + 711.0389999999998, + 138.13699999999994 + ], + "priority": 34, + "parents": [ + 80431 + ], + "children": [], + "area": 6107141.0306939995, + "iscrowd": 0, + "segmentation": [], + "text": "In pools disconeccted for more than 40 days, the\nnumber of salmonids counted increased as pool\nvolume increased; survival respondse differed be-\n\ntween species." + }, + { + "id": 80437, + "strid": "db1cecf2-0d27-4ade-8778-6ddb336f4ddd", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3172.952, + 1810.275, + 775.7269999999999, + 657.969 + ], + "priority": 35, + "parents": [ + 80431 + ], + "children": [], + "area": 5743915.6818, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 80440, + "strid": "6df18667-dc9a-4c78-a8ef-a3e1aa28debd", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3158.906, + 2495.014, + 767.6930000000002, + 102.76299999999992 + ], + "priority": 36, + "parents": [ + 80431 + ], + "children": [], + "area": 7881514.694684001, + "iscrowd": 0, + "segmentation": [], + "text": "Net daily metabolism (g O,/ m?-d) and continuous mea-\nsurements of water depth (m) in Fay Creek after a 5 cm\nrain event, June 26 — July 2, 2013." + }, + { + "id": 80438, + "strid": "a7609909-e76f-485e-be62-8b1f8a1f724e", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 4034.052, + 1826.466, + 761.0070000000001, + 637.3620000000001 + ], + "priority": 37, + "parents": [ + 80431 + ], + "children": [], + "area": 7368058.820232, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 80439, + "strid": "ba4215b4-fa6a-40a3-95d0-a16aa2deb9d2", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4073.796, + 2491.796, + 765.4230000000002, + 100.09400000000005 + ], + "priority": 38, + "parents": [ + 80431 + ], + "children": [], + "area": 10151068.577615999, + "iscrowd": 0, + "segmentation": [], + "text": "Net daily metabolism (g O,/ m?-d) and continuous water\ntemperature measurements (°C) in Tannery,Greek in early\nand late July, 2014." + }, + { + "id": 80422, + "strid": "b268cb57-69b2-4763-b4af-f099a7c1242e", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3164.311, + 2696.519, + 755.4450000000002, + 613.5369999999998 + ], + "priority": 39, + "parents": [ + 80431 + ], + "children": [], + "area": 8532624.733409, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 80423, + "strid": "0db735f7-ecbe-47e7-ba12-cedf59ea931e", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3167.201, + 3315.801, + 736.4700000000003, + 172.3409999999999 + ], + "priority": 40, + "parents": [ + 80431 + ], + "children": [], + "area": 10501808.243001, + "iscrowd": 0, + "segmentation": [], + "text": "Linear model of metabolism (g O,/ m?-d) and water\ndepth with combined data from June 26 — July 5, 2043;\nand September 2 - 8, 2013 on Fay Creek and July ‘4, “7,\n2014 and July 23 — 29, 2014 on Tannery Greek (R?\n0.7028, p < 0.001)." + }, + { + "id": 80441, + "strid": "607ba674-4da9-4a55-8d3b-2e9866aa2a56", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 4054.81, + 2688.633, + 764.4140000000002, + 616.8959999999997 + ], + "priority": 41, + "parents": [ + 80431 + ], + "children": [], + "area": 10901895.97473, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 80442, + "strid": "2d15bcc0-c04a-4323-9a45-f64a38f917ab", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4073.239, + 3315.686, + 728.3179999999998, + 167.2550000000001 + ], + "priority": 42, + "parents": [ + 80431 + ], + "children": [], + "area": 13505581.526954, + "iscrowd": 0, + "segmentation": [], + "text": "Linear model of metabolism (g O,/ m?-d) and water tem-\nperature (°C) with combined data from June 26 — July 5,\n2013, and September 2 - September 8, 2013 from Fay\nCreek and July 1 — July 7, 2014 and July 23 —July 29,\n2014 from Tannery Creek (R? 0.3558, p < 0.001):" + }, + { + "id": 80432, + "strid": "73ca0ac3-8e00-4bcf-8afe-ee8110092af9", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4997.05, + 595.881, + 183.10300000000007, + 49.51800000000003 + ], + "priority": 43, + "parents": [ + 80450 + ], + "children": [ + 80449, + 80448, + 80447 + ], + "area": 2977647.15105, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 80449, + "strid": "02a07b63-8e7b-4eae-a473-679c9ab063dd", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4993.465, + 657.92, + 835.4859999999999, + 692.602 + ], + "priority": 44, + "parents": [ + 80432 + ], + "children": [], + "area": 3285300.4928, + "iscrowd": 0, + "segmentation": [], + "text": "1. What drives salmonid over-summer'survival?\n\nOur preliminary results indicate that salmonid recruitment can\nbe very high in intermittent streams;and was higher on inter-\nmittent Fay than continuous Tannery in 2012, 2013, and 2014\n(Figure 3). A lower percentage of salmonids survived in Fay\nCreek compared to Tannery Creek and in intermittent com-\npared to continuous pools (Figure 4 a, b). However, overall\nabundance was higher in Fay than in Tannery at the end of the\nsummer in both 2013,and 2012, suggesting that even in an in-\ntermittent stateyFay-salmonids play an important role in sus-\ntaining the population complex overall.\n\nWe evaluated survival using univariate and multivariate logis-\ntical regression models using all water quality and habitat pa-\nrameters measured, and compared models using AIC (Figure\n5). The most informative model was:\n\nSurvival probability = (percent survival) ~ minimum DO +\nmaximum conductivity + days disconnected + minimum volume" + }, + { + "id": 80448, + "strid": "ffa477da-7e87-438c-b15a-869ccf09ec8b", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 4990.367, + 1386.385, + 858.4780000000001, + 196.06600000000003 + ], + "priority": 45, + "parents": [ + 80432 + ], + "children": [], + "area": 6918569.953295, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 80447, + "strid": "e564dfe8-d443-414a-b13f-b209f3d15b81", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4990.367, + 1610.853, + 859.3940000000002, + 526.8139999999999 + ], + "priority": 46, + "parents": [ + 80432 + ], + "children": [], + "area": 8038747.653051001, + "iscrowd": 0, + "segmentation": [], + "text": "2. What abiotic factors characterize sanctuary reaches?\n\nIntermittency— measured as the days,since’stream disconnec-\ntion—was the most significant predictor of salmonid survival in\nunivariate models (Figure 5). In.aymultivariate framework, the\nbest model included days since disconnection, DO, pool\nvolume, and maximum conductivity (an indicator of groundwa-\nter inflow) (Table 1). Our results show that the duration of com-\nplete disconnection:of pools during the summer months as well\nas stream metabolic rates are positively correlated with salmo-\nnid mortality. We*found that DO drops to critical levels in many\nisolated poolsyandvare currently evaluating the hypothesis that\nminimum’ DO, levels are correlated with high organic matter\ncontent,/lOng» upstream subsurface flow paths, and length of\ntime in the fragmented state." + }, + { + "id": 80446, + "strid": "b1d81608-0404-472d-ac7b-256147629eef", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4992.199, + 2210.047, + 270.27899999999954, + 49.47499999999991 + ], + "priority": 47, + "parents": [ + 80450 + ], + "children": [ + 80445 + ], + "area": 11032994.423353, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion" + }, + { + "id": 80445, + "strid": "cac1e9c6-b21f-4b1d-b69d-950527e0da0e", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4991.833, + 2299.285, + 852.6140000000005, + 951.1970000000001 + ], + "priority": 48, + "parents": [ + 80446 + ], + "children": [], + "area": 11477646.739404999, + "iscrowd": 0, + "segmentation": [], + "text": "Once streams become intermittent, pool characteristics deter-\nmine whether salmonids survive the dry period. We found evi-\ndence that mortality can result from total dessication, predation\nin small, shallow pools, or DO depletion. Of the study pools\nwhere salmonids did not survive, some later dried completely,\nsome exhibited lethal DO levels, and some were.alsovless than\n0.4 m deep in October. High mortality in pools:less,than 0.4 m\ndeep that lacked large woody debris or undercut banks sug-\ngests that raccoons or wading birds are efficient salmonid pred-\nators in shallow pools.\n\nSanctuary reaches occupy a relatively small proportion of over-\nall stream length, yet can support*high densities of both coho\nand steelhead. Thus an important second avenue of research\nis to determine what.characterizes these sanctuary reaches.\nHigh salmonid survival in some isolated “sanctuary” pools was\ncorrelated with the \\presence of groundwater seeps, depth\ngreater than 0.4* m, and volume greater than 10 m%. Coho\nappear more sensitive to volume than do steelhead; coho sur-\nvived in higher numbers than did steelhead in pools larger than\n8 m*.,Spring-fed tributaries maintained DO levels > 7 ppm\nthrough*the’dry season and elevated DO levels in pools down-\nstream. We suspect that hyporheic and groundwater inflow play\na similar role since these waters are lower in labile organic\ncarbon and thus support lower metabolism; we are currently\nevaluating this hypothesis." + }, + { + "id": 80443, + "strid": "4d7fb7ff-97e3-437d-93df-1cf59ea6458d", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4994.471, + 3283.575, + 275.51900000000023, + 49.25500000000011 + ], + "priority": 49, + "parents": [ + 80450 + ], + "children": [ + 80444 + ], + "area": 16399720.113824997, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 80444, + "strid": "a8b35011-4763-49d6-acba-e0482bc96769", + "image_id": 203636, + "image_name": "120614.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 4992.932, + 3349.761, + 835.0230000000001, + 191.63200000000006 + ], + "priority": 50, + "parents": [ + 80443 + ], + "children": [], + "area": 16725128.889252, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 113813, + "strid": "a52bfa7e-e14b-4d28-b097-4de9c96af639", + "image_id": 204915, + "image_name": "13503.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 177.51, + 242.75, + 208.03000000000003, + 227.82999999999998 + ], + "priority": -1, + "parents": [], + "children": [ + 113803, + 113808, + 113800, + 113799, + 113801, + 113802, + 113809, + 113807 + ], + "area": 43090.5525, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 113799, + "strid": "83d9f701-3a52-474a-9a80-5fc9eba7065e", + "image_id": 204915, + "image_name": "13503.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 451.528, + 136.06, + 2296.201, + 398.1480000000001 + ], + "priority": 1, + "parents": [ + 113813 + ], + "children": [], + "area": 61434.89968, + "iscrowd": 0, + "segmentation": [], + "text": "RNA-seg transcriptome profiles of whole\n_ blood associated to IGF-1 in cattle: ~\non primiparous vs multiparous" + }, + { + "id": 113800, + "strid": "b64cde62-4eec-4b3a-ab7d-ddbdd6a04d81", + "image_id": 204915, + "image_name": "13503.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 28.997, + 719.895, + 3243.76, + 183.06899999999996 + ], + "priority": 2, + "parents": [ + 113813 + ], + "children": [], + "area": 20874.795315, + "iscrowd": 0, + "segmentation": [], + "text": "Laura Buggiotti, Zhangrui Cheng, Mazdak Salavati, Haruko Takeda, Claire Wathes,\nand Genotype plus Environment Consortium" + }, + { + "id": 113801, + "strid": "f8f118a3-01ba-4c0a-8710-3a8843d203ea", + "image_id": 204915, + "image_name": "13503.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 524.436, + 1124.209, + 549.4, + 62.81700000000001 + ], + "priority": 3, + "parents": [ + 113813 + ], + "children": [ + 113804 + ], + "area": 589575.6711240001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 113804, + "strid": "147625e8-03a9-465b-b92d-a554c11fefcc", + "image_id": 204915, + "image_name": "13503.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 54.016, + 1257.883, + 1539.844, + 386.96900000000005 + ], + "priority": 4, + "parents": [ + 113801 + ], + "children": [], + "area": 67945.808128, + "iscrowd": 0, + "segmentation": [], + "text": "Insulin-like growth factor 1 (IGF-1) plays an important physiological\nrole in metabolism, immunity and fertility. The circulating\nconcentration of IGF-1 in early lactation has been suggested as a\npotential physiological marker for improved efficiency and\nprofitability in cattle production. These relationships are known to\nchange as cows age’." + }, + { + "id": 113802, + "strid": "06e45a98-b0ad-4ccd-8ac5-e42772969dd9", + "image_id": 204915, + "image_name": "13503.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 396.9, + 1740.172, + 809.773, + 66.41699999999992 + ], + "priority": 5, + "parents": [ + 113813 + ], + "children": [ + 113805 + ], + "area": 690674.2668, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 113805, + "strid": "db30fdd5-7e95-46ee-a746-ddedb08fdbc5", + "image_id": 204915, + "image_name": "13503.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 53.453, + 1877.966, + 1541.73, + 852.1839999999997 + ], + "priority": 6, + "parents": [ + 113802 + ], + "children": [], + "area": 100382.916598, + "iscrowd": 0, + "segmentation": [], + "text": "A total of 225 cows (53 primiparous, PP, and 172 multiparous,\nMP22) were recruited from six experimental farms. Blood samples\nwere collected at 14+3 days after calving for (i) IGF1 measurement\nby RIA and (ii) Tempus tubes for preparation of whole blood RNA.\nLibraries were prepared by using 0.75 ug of total RNA and\nsequenced on the Illumina NextSeq 500 sequencer. The latest Bos\ntaurus assembly (ARS-UCD1.2) and its corresponding gene set was\nused as reference to map reads by HISAT2. BAM files were further\nprocessed with Picard Tools to remove PCR duplicates. Reads per\ngene were counted with StringTie and normalized FPKM were then\nused in (i) a correlation analysis with IGF-1 and (ii) to compare\ndifferential expression between PP and older cows (MP>3\nlactations)." + }, + { + "id": 113807, + "strid": "26e79fdb-7ba6-4eb8-9336-a80ca938dc01", + "image_id": 204915, + "image_name": "13503.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 192.968, + 2753.992, + 1274.019, + 718.009 + ], + "priority": 7, + "parents": [ + 113813 + ], + "children": [ + 113811 + ], + "area": 531432.328256, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 113811, + "strid": "144e9335-b04a-437b-83d3-2057f9f37fa6", + "image_id": 204915, + "image_name": "13503.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 187.327, + 3489.698, + 1267.813, + 168.5949999999998 + ], + "priority": 8, + "parents": [ + 113807 + ], + "children": [], + "area": 653714.657246, + "iscrowd": 0, + "segmentation": [], + "text": "Fig 1. Venn diagram of the correlation analysis of FPKM with\nIGF-1 between multiparous (MP) and primiparous (PP) cows.\nAll genes with p.value <0.05 and R2 was in the range 0.03-0.5." + }, + { + "id": 113809, + "strid": "6d83216e-80ca-4187-8e43-9ceeaf6de4c2", + "image_id": 204915, + "image_name": "13503.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1773.513, + 1127.439, + 1274.5500000000002, + 940.8979999999999 + ], + "priority": 9, + "parents": [ + 113813 + ], + "children": [ + 113810 + ], + "area": 1999527.723207, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 113810, + "strid": "08853409-5898-4515-a1d4-fb9edfc7e58a", + "image_id": 204915, + "image_name": "13503.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1769.663, + 2103.745, + 1268.7090000000003, + 167.67599999999993 + ], + "priority": 10, + "parents": [ + 113809 + ], + "children": [], + "area": 3722919.687935, + "iscrowd": 0, + "segmentation": [], + "text": "Fig 2. Volcano plot displaying significant (p.adj<0.05)\ndifferentially expressed genes in whole blood at 14 days\npostpartum between MP and PP cows (1°t and >3 lactations)." + }, + { + "id": 113803, + "strid": "1fc51223-7fda-411c-8caf-6982dd7f8a44", + "image_id": 204915, + "image_name": "13503.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2118.721, + 2408.653, + 781.1039999999998, + 66.95699999999988 + ], + "priority": 11, + "parents": [ + 113813 + ], + "children": [ + 113806 + ], + "area": 5103263.692813, + "iscrowd": 0, + "segmentation": [], + "text": "Results and Discussion" + }, + { + "id": 113806, + "strid": "ee62f35d-3721-440b-8f53-09b3de050980", + "image_id": 204915, + "image_name": "13503.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1714.348, + 2563.067, + 1540.5439999999999, + 919.031 + ], + "priority": 12, + "parents": [ + 113803 + ], + "children": [], + "area": 4393988.785316, + "iscrowd": 0, + "segmentation": [], + "text": "Correlation analysis highlighted 6093 and 4654 genes to be\nsignificantly correlated with IGF-1 in MP and PP, respectively (Fig.\n1). Interestingly, the majority of the top genes (p.value <1x10-10,\n2>f.change>2) found to be highly differentially expressed between\nthe two groups (MP>3 and PP, Fig. 2) are significantly correlated\nwith IGF-1 as well. Most were found in metabolic pathways, like\nSOX13, IGF2BP3, ZNF462, TWIST1.\n\nKEGG enrichment analysis (Fig. 3) of the same data also highlighted\na few disease related pathways when overlapping gene sets were\ninvestigated. PP specific genes revealed a different pathway\nenrichment landscape if compared with MP specific genes,\nincluding several viral pathways. This is a preliminary analysis and\nfurther gene investigation is needed to better understand the\ncomplexity of IGF-1 actions in primiparous and multiparous cows." + }, + { + "id": 113808, + "strid": "906aa04f-8f4f-43a7-ae53-cebd78e19026", + "image_id": 204915, + "image_name": "13503.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 205.946, + 3715.957, + 2678.119, + 762.065 + ], + "priority": 13, + "parents": [ + 113813 + ], + "children": [ + 113812 + ], + "area": 765286.480322, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 113812, + "strid": "109ab17e-eadc-424d-8500-c557da1d0cbc", + "image_id": 204915, + "image_name": "13503.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 202.433, + 4510.521, + 2568.064, + 47.23400000000038 + ], + "priority": 14, + "parents": [ + 113808 + ], + "children": [], + "area": 913078.2975929999, + "iscrowd": 0, + "segmentation": [], + "text": "Fig 3. KEGG enrichment analysis of significantly correlated genes with IGF-1 of MIP-, PP- specific, and MP-PP overlapping genes." + }, + { + "id": 154125, + "strid": "6a424561-79fa-4880-ade8-4cfb51442fab", + "image_id": 206507, + "image_name": "22545.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 26.25, + 89.94, + 67.04, + 227.95999999999998 + ], + "priority": -1, + "parents": [], + "children": [ + 154111, + 154106, + 154110, + 154107, + 154108, + 154121, + 154112 + ], + "area": 2360.9249999999997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 154106, + "strid": "66bd7b22-1a9c-4ce1-9b10-c79f858f553a", + "image_id": 206507, + "image_name": "22545.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 135.977, + 51.791, + 2451.244, + 278.426 + ], + "priority": 1, + "parents": [ + 154125 + ], + "children": [], + "area": 7042.3848069999995, + "iscrowd": 0, + "segmentation": [], + "text": "Improving reproducibility of AcoleaTolt) ational\nanalyses performed on the ELIXIR-GR cloud" + }, + { + "id": 154107, + "strid": "53a61508-6849-45dc-a2f6-62b673574551", + "image_id": 206507, + "image_name": "22545.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 133.557, + 368.303, + 1987.11, + 119.274 + ], + "priority": 2, + "parents": [ + 154125 + ], + "children": [], + "area": 49189.443771, + "iscrowd": 0, + "segmentation": [], + "text": "Aikaterina Mastoraki\", Panagiotis Deligianni Eleni Adamidi’, Thanasis Pe\nMSI, “Athena” RC a 8 _. c y\n\n~~ Pome\n\n;" + }, + { + "id": 154108, + "strid": "f926de12-b350-4c28-ac64-9b7cfdf32712", + "image_id": 206507, + "image_name": "22545.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 106.073, + 739.506, + 3126.303, + 248.68500000000006 + ], + "priority": 3, + "parents": [ + 154125 + ], + "children": [], + "area": 78441.61993799999, + "iscrowd": 0, + "segmentation": [], + "text": "HYPATIA is the Cloud infrastructure that has been developed to support the computational needs of the ELIXIR-GR community. It leverages SCHEMA, an open-source\nplatform developed by members of the ELIXIR-GR community, to offer to its users a functionality to run on-demand computational analyses on the underlying,\nheterogeneous cluster. One key feature of SCHEMA is that it exploits containerization (e.g., Docker), experiment packaging (e.g., RO-Crates), and workflow management\n(e.g., CWL) technologies to facilitate reproducibility of the respective analyses. In this poster, we present this functionality and we elaborate on our plans to extend it in the\ncontext of TIER2, a new Horizon Europe project for research reproducibility into which we participate." + }, + { + "id": 154110, + "strid": "e56ad825-695c-497d-9bfb-c5e61807423d", + "image_id": 206507, + "image_name": "22545.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 102.031, + 1049.647, + 1231.042, + 82.84899999999993 + ], + "priority": 4, + "parents": [ + 154125 + ], + "children": [ + 154124, + 154123, + 154115 + ], + "area": 107096.533057, + "iscrowd": 0, + "segmentation": [], + "text": "HYPATIA Cloud Infrastructure" + }, + { + "id": 154115, + "strid": "5470840e-003d-4fdc-8880-f5a0048ed30a", + "image_id": 206507, + "image_name": "22545.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 100.479, + 1173.727, + 1150.517, + 70.5329999999999 + ], + "priority": 5, + "parents": [ + 154110 + ], + "children": [], + "area": 117934.915233, + "iscrowd": 0, + "segmentation": [], + "text": "ELIXIR-GR services and resources" + }, + { + "id": 154124, + "strid": "eaa0dfb8-4801-4807-9fb2-7f9e7c71cbb3", + "image_id": 206507, + "image_name": "22545.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 98.747, + 1285.528, + 1598.913, + 195.279 + ], + "priority": 6, + "parents": [ + 154110 + ], + "children": [], + "area": 126942.033416, + "iscrowd": 0, + "segmentation": [], + "text": "HYPATIA [1] is the Cloud infrastructure that has been developed to support the\ncomputational needs of the. ELIXIR-GR community, but also the. broader\ncommunity of life scientists in Greece and abroad. HYPATIA consists of a\npowerful computational cluster of heterogeneous physical machines. Currently,\n\nhe cluster is comprised of:" + }, + { + "id": 154123, + "strid": "003a3615-2bd7-402a-91e1-b7fd0fe145f7", + "image_id": 206507, + "image_name": "22545.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 103.258, + 1481.101, + 1591.497, + 256.8499999999999 + ], + "priority": 7, + "parents": [ + 154110 + ], + "children": [], + "area": 152935.527058, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 154111, + "strid": "671e3a01-18bc-4159-941a-172a4b149a69", + "image_id": 206507, + "image_name": "22545.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 119.377, + 1823.811, + 755.757, + 80.30300000000011 + ], + "priority": 8, + "parents": [ + 154125 + ], + "children": [ + 154114, + 154118, + 154116, + 154109, + 154120, + 154117 + ], + "area": 217721.08574699998, + "iscrowd": 0, + "segmentation": [], + "text": "SCHEMA Platform" + }, + { + "id": 154116, + "strid": "39a0877f-34b8-4fb7-b0e0-b45f82cfcb44", + "image_id": 206507, + "image_name": "22545.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 118.87, + 1956.045, + 1097.951, + 78.75 + ], + "priority": 9, + "parents": [ + 154111 + ], + "children": [], + "area": 232515.06915000002, + "iscrowd": 0, + "segmentation": [], + "text": "Scheduling Scientific Containers" + }, + { + "id": 154117, + "strid": "6fe43cf6-e165-490a-a1e1-6859c73ed384", + "image_id": 206507, + "image_name": "22545.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 118.83, + 2075.131, + 1550.616, + 360.93499999999995 + ], + "priority": 10, + "parents": [ + 154111 + ], + "children": [], + "area": 246587.81673, + "iscrowd": 0, + "segmentation": [], + "text": "on a Cluster of Heterogeneous Machines\n\nHYPATIA leverages SCHEMA [2], an open-source platform developed by\nmembers of the ELIXIR-GR community, that facilitates the execution and\nreproducibility of computational analysis on heterogeneous clusters, leveraging\ncontainerization, experiment packaging, workflow management, and machine\nlearning technologies [3]." + }, + { + "id": 154118, + "strid": "651f7b20-2083-4238-b476-3e0d27b758c0", + "image_id": 206507, + "image_name": "22545.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 118.232, + 2477.675, + 1553.886, + 465.28600000000006 + ], + "priority": 11, + "parents": [ + 154111 + ], + "children": [], + "area": 292940.4706, + "iscrowd": 0, + "segmentation": [], + "text": "SCHEMA Functionalities\n\nSCHEMA implements a wide range of functionalities to assist scientists in the\ndata-driven and reproducible science era. Most notable are (a) the option to\nupload custom-made scientific containers or container-based workflows, (b) a\nwizard and an API that facilitate the execution of individual containers or\nworkflows, (c) a monitor that informs the users about the consumption of\ncomputational resources, (d) a wizard to transform executed analyses into RO-\ncrate-based “experiment packages”, and (e) a _ wizard to facilitate\ninterconnection with open data repository services [3]." + }, + { + "id": 154120, + "strid": "a0e8632e-7900-42d8-8154-f34f28a8a07f", + "image_id": 206507, + "image_name": "22545.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 114.846, + 2991.471, + 1555.259, + 1021.614 + ], + "priority": 12, + "parents": [ + 154111 + ], + "children": [], + "area": 343558.478466, + "iscrowd": 0, + "segmentation": [], + "text": "Automatic creation of RO-crates from\nexecutions\n\nA Research Object (RO) combines the ability to bundle multiple types of\nartefacts together, such as spreadsheets, code, examples, and figures [4]. RO-\nCrate (Research Object Crate) is a method of organizing file-based data with\nassociated metadata, using linked data principles, in both human and machine-\nreadable formats, with the ability to include additional domain-specific\nmetadata.\n\nThe core of RO-Crate is a JSON-LD (JSON for Linked Data) file that contains\nstructured metadata about the dataset as a whole (the Root Data Entity) and,\noptionally, about some or all of its files. This provides a simple way to assert\nthe authors (e.g. people, organizations) of the RO-Crate, or to capture more\ncomplex provenance for files, such as how they were created using software\nand equipment [4].\n\nOne key feature of SCHEMA is that it exploits containerization (e.g., Docker),\nexperiment packaging (e.g., RO-Crates), and workflow management (e.g., CWL)\ntechnologies to facilitate reproducibility of the respective analyses." + }, + { + "id": 154109, + "strid": "98c9276c-6d7a-467c-855e-5ae92c9d7ace", + "image_id": 206507, + "image_name": "22545.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1765.374, + 1064.014, + 1459.264, + 262.9680000000001 + ], + "priority": 13, + "parents": [ + 154111 + ], + "children": [], + "area": 1878382.6512359998, + "iscrowd": 0, + "segmentation": [], + "text": "More specifically, each workflow execution can be easily transformed into\nan RO-crate object that incorporates all the metadata that are required for\nit to be re-executed (i.e., the location of the container images involved, the\nsoftware configuration used, the respective input and output data, etc.),\n(see Fig. 1)." + }, + { + "id": 154114, + "strid": "f57057a2-f53b-4c0e-8a40-9dbdc50e3acb", + "image_id": 206507, + "image_name": "22545.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2074.235, + 1332.14, + 684.4119999999998, + 649.489 + ], + "priority": 14, + "parents": [ + 154111 + ], + "children": [ + 154113 + ], + "area": 2763171.4129000003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 154113, + "strid": "f081534f-cc2d-4c90-9dd6-ea7c6b4d8878", + "image_id": 206507, + "image_name": "22545.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2034.96, + 2001.152, + 771.9189999999999, + 41.57899999999995 + ], + "priority": 15, + "parents": [ + 154114 + ], + "children": [], + "area": 4072264.27392, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 1. SCHEMA packaging research artefacts" + }, + { + "id": 154112, + "strid": "3d118b50-f656-46a1-9877-f24a772a18a1", + "image_id": 206507, + "image_name": "22545.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1744.371, + 2110.394, + 658.7690000000002, + 77.76999999999998 + ], + "priority": 16, + "parents": [ + 154125 + ], + "children": [ + 154119 + ], + "area": 3681310.0921739996, + "iscrowd": 0, + "segmentation": [], + "text": "Future Research" + }, + { + "id": 154119, + "strid": "799124e3-7e33-44a1-ab66-71be8866a353", + "image_id": 206507, + "image_name": "22545.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1740.179, + 2213.539, + 1460.562, + 1203.404 + ], + "priority": 17, + "parents": [ + 154112 + ], + "children": [], + "area": 3851954.0834810007, + "iscrowd": 0, + "segmentation": [], + "text": "TIER2 project\n\nReproducibility is often claimed as a central principle of the scientific\nmethod referring to the possibility for the scientific community to obtain\nthe same results as the originators of a specific finding [5]. Poor\nreproducibility is identified in many research areas, particularly in\ncomputationally intensive domains where results rely on a series of\ncomplex methodological decisions that are not well captured by traditional\npublication approaches [6].\n\nTIER2 is a new _ Horizon European project aiming to increase\nreproducibility of scientific research results that will bring trust, integrity,\nand efficiency to the European Research Area (ERA) and the global\nResearch and Innovation (R&I) system [7].\n\nIn the context of TIER2, we aim to adapt & extend SCHEMA to further\nfacilitate data/code reproducibility in life sciences, computer sciences and\nsocial sciences. More specifically, we plan to (a) examine alternative\nrepresentations of reproducible objects (various RO-crate templates,\nother choices like ReproZip, Packrat, etc.), (b) improve the accessibility and\nsearchability of these objects, (c) simplify the execution of these objects\nand (d) investigate domain-specific aspects." + }, + { + "id": 154121, + "strid": "d096b6b3-5bdb-4dc4-a3d6-1d87196dfa09", + "image_id": 206507, + "image_name": "22545.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1746.082, + 3442.085, + 333.8430000000001, + 58.95699999999988 + ], + "priority": 18, + "parents": [ + 154125 + ], + "children": [ + 154122 + ], + "area": 6010162.660970001, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 154122, + "strid": "9cda9494-415c-4858-98a8-1668bfb3735d", + "image_id": 206507, + "image_name": "22545.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1741.397, + 3511.92, + 1497.531, + 559.3130000000001 + ], + "priority": 19, + "parents": [ + 154121 + ], + "children": [], + "area": 6115646.95224, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 88288, + "strid": "ff29d5c8-b6d9-463a-afb9-d8805fc247d2", + "image_id": 203929, + "image_name": "12119.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 404.73, + 82.81, + 330.13, + 306.96999999999997 + ], + "priority": -1, + "parents": [], + "children": [ + 88263, + 88268, + 88284, + 88265, + 88264, + 88267, + 88269, + 88266 + ], + "area": 33515.691300000006, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 88263, + "strid": "f2bc177e-9986-4062-9f5d-5f7b6f2490f9", + "image_id": 203929, + "image_name": "12119.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 870.993, + 166.647, + 3208.895, + 258.778 + ], + "priority": 1, + "parents": [ + 88288 + ], + "children": [], + "area": 145148.370471, + "iscrowd": 0, + "segmentation": [], + "text": "ESG: Extended Similarity Group Method for Automated\nProtein Function Prediction" + }, + { + "id": 88264, + "strid": "88d63d0d-d95c-4b05-be4b-a1dc99270353", + "image_id": 203929, + "image_name": "12119.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 280.997, + 453.21, + 4169.986, + 246.873 + ], + "priority": 2, + "parents": [ + 88288 + ], + "children": [], + "area": 127350.65037, + "iscrowd": 0, + "segmentation": [], + "text": "Meghana Chitale’, Troy Hawkins: Changsoon Park? and Daisuke Kihara‘:\n{ mchitale, thawkins, dkihara }@purdue.edu, cspark@cau.ac.kr\n‘Department of Computer Science, 7Department of Biological Sciences, Purdue University, IN 47907,USA ,*7Department of Statistics, Chung-Ang University, Seoul, Korea." + }, + { + "id": 88265, + "strid": "bed1c8e3-e684-4470-a9f8-1deecee73873", + "image_id": 203929, + "image_name": "12119.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 100.774, + 784.618, + 232.735, + 30.851 + ], + "priority": 3, + "parents": [ + 88288 + ], + "children": [ + 88271, + 88270, + 88272 + ], + "area": 79069.09433200001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 88270, + "strid": "78c9f9fe-605c-41fd-aa55-a78f4c8d313e", + "image_id": 203929, + "image_name": "12119.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 107.068, + 909.471, + 1453.097, + 317.54999999999995 + ], + "priority": 4, + "parents": [ + 88265 + ], + "children": [], + "area": 97375.241028, + "iscrowd": 0, + "segmentation": [], + "text": "Motivation: Importance of accurate automatic protein function pre-diction is ever increasing in the\nface of a large number of newly sequenced genomes and proteomics data that are awaiting\nbiological interpretation. Conventional methods have focused on high sequence similarity based\nannotation transfer that is based on the concept of homology. However, many cases have been\nreported that simple transfer of function from top hits of a homology search causes erroneous\nfunction annotation. New methods are required to handle the sequence similarity in a more robust\nway to combine together signals from strongly and weakly similar proteins for effectively\npredicting functional annotation for unknown proteins with high reliability." + }, + { + "id": 88271, + "strid": "75167b61-797d-47fc-94cb-5cc23227465e", + "image_id": 203929, + "image_name": "12119.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 107.598, + 1249.393, + 1452.179, + 358.00700000000006 + ], + "priority": 5, + "parents": [ + 88265 + ], + "children": [], + "area": 134432.188014, + "iscrowd": 0, + "segmentation": [], + "text": "Results: We present the Extended Similarity Group (ESG) method, which performs iterative\nsequence database searches and annotates query sequences with Gene Ontology terms. Each\nannotation is assigned with probability based on its relative similarity index with the multiple level\nneighbors in the protein similarity graph. We will depict how the statistical framework of ESG\nimproves the prediction accuracy by iteratively taking into account the neighborhood of query\nprotein in the sequence similarity space. ESG outperforms conventional PSI-BLAST and PFP’,\nwhich we have developed previously. It is found that the iterative search is effective in capturing\nmultiple-domains in a query protein, enabling accurately predicting several functions which\noriginate from different domains." + }, + { + "id": 88272, + "strid": "149914ca-06f0-46bc-9d8f-bca5d8cf368d", + "image_id": 203929, + "image_name": "12119.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 106.711, + 1629.478, + 1453.841, + 77.6579999999999 + ], + "priority": 6, + "parents": [ + 88265 + ], + "children": [], + "area": 173883.226858, + "iscrowd": 0, + "segmentation": [], + "text": "Availability: ESG web server is available for automated protein function prediction at\nhttp://dragon.bio.purdue.edu/ESG/ y" + }, + { + "id": 88269, + "strid": "25bf8f31-6904-4dac-9135-f855d618d88a", + "image_id": 203929, + "image_name": "12119.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 92.198, + 1784.67, + 451.731, + 30.11500000000001 + ], + "priority": 7, + "parents": [ + 88288 + ], + "children": [ + 88275, + 88274 + ], + "area": 164543.00466, + "iscrowd": 0, + "segmentation": [], + "text": "2. METHOD DESSCRIPTIO" + }, + { + "id": 88274, + "strid": "856a7292-c0e6-4177-ac9b-4ec81d90ddce", + "image_id": 203929, + "image_name": "12119.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 401.8, + 1878.374, + 794.325, + 405.60900000000015 + ], + "priority": 8, + "parents": [ + 88269 + ], + "children": [ + 88273 + ], + "area": 754730.6732000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 88273, + "strid": "6e35f949-55fb-46a5-b25a-1ec74308ff76", + "image_id": 203929, + "image_name": "12119.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 519.985, + 2317.148, + 659.611, + 38.83699999999999 + ], + "priority": 9, + "parents": [ + 88274 + ], + "children": [], + "area": 1204882.2027800002, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. Two level ESG score computation." + }, + { + "id": 88275, + "strid": "e81e725f-7f14-4015-a006-1282e19be5cf", + "image_id": 203929, + "image_name": "12119.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 98.699, + 2373.742, + 1470.618, + 1139.024 + ], + "priority": 10, + "parents": [ + 88269 + ], + "children": [], + "area": 234285.96165800001, + "iscrowd": 0, + "segmentation": [], + "text": "Consider a query sequence Q whose annotations are to be determined. We perform the PSI-\nBLAST search for Q to obtain homologous sequences S,,54,S3... Sy. These PSI-BLAST hits have\nE-values E,,E,,E3... Ey for each S; respectively. Then the weight W, for sequence S; is computed\nas below in equation (1) based on the E-values of all sequence hits obtained at first level.\n\nEq (2)\n\n—log(£i) +b if Si . :\nWi= Eq (1) Is(f) = 1 if Sihas fa annotation\n0 otherwise\n\nDH log) +5}\nPi) = Wilh) Eq 8)\n\nUsing just the level 1 of ESG the probability PQ4(f,) that sequence Q can have annotation f,, can\nbe computed as in equation 3 by summing up the scores of all the sequences at level 1 that have\nannotation f,. Now we move on to second level of ESG where we do PSI-BLAST search from each\nof the sequence §S;, obtained at the first level of ESG as shown in Figure 1. As shown in equation 2,\ninstead of using just I,(f,), we compute P.(f,) by applying the scoring technique recursively at level\n2 beginning from sequence §S,. Using the step weight v we allocate part of the score to whether the\nsequence S, has annotation f, and part of the score is computed using sequence hits from S, using\nthe same weighing method as in level 1. For benchmarking we have used N=50 and step weight\nof 0.5 which allocates equal importance to both levels.\n\nPH fi = vel f+ U=v)-Wy If) eae\n\n\\ Po( fa) => Wi-PS (fz) Eq (5)" + }, + { + "id": 88266, + "strid": "1a5ef366-e87f-40b4-b1f8-79fe764281de", + "image_id": 203929, + "image_name": "12119.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1675.438, + 783.975, + 409.11299999999983, + 31.682000000000016 + ], + "priority": 11, + "parents": [ + 88288 + ], + "children": [ + 88281, + 88282, + 88285, + 88279, + 88283, + 88280 + ], + "area": 1313501.5060500002, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 88280, + "strid": "5beb2f4c-81df-4d71-b9ae-bceb6e435ade", + "image_id": 203929, + "image_name": "12119.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1949.213, + 894.936, + 1062.6940000000002, + 576.6549999999999 + ], + "priority": 12, + "parents": [ + 88266 + ], + "children": [ + 88276 + ], + "area": 1744420.885368, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 88276, + "strid": "42b18275-beec-44aa-ab19-5961a0af26af", + "image_id": 203929, + "image_name": "12119.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1960.072, + 1501.009, + 889.2839999999999, + 38.30400000000009 + ], + "priority": 13, + "parents": [ + 88280 + ], + "children": [], + "area": 2942085.7126479996, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2. Precision Recall curves for benchmarking dataset" + }, + { + "id": 88282, + "strid": "b90ad02f-5426-4e5d-ae68-8e42ea318909", + "image_id": 203929, + "image_name": "12119.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1721.649, + 1577.645, + 1421.973, + 280.11699999999996 + ], + "priority": 14, + "parents": [ + 88266 + ], + "children": [], + "area": 2716150.936605, + "iscrowd": 0, + "segmentation": [], + "text": "We have done ESG predictions for a set of randomly selected 2400 protein sequences from 12\ndifferent species and computed precision and recall for each species with different probability\nthresholds. With the probability cutoff of 0.35, we obtained fairly optimum precision of 68% and\nrecall of 58%. For higher probability cutoffs above 0.35, there was no strong increase in the\nprecision but the recall was falling sharply. At higher cutoffs the number of terms predicted was\nfar less as compared to the false negatives in the prediction. Therefore, for analysis described\nbelow, we used the probability cutoff of 0.35 for predicting annotations by ESG. /" + }, + { + "id": 88281, + "strid": "18e2704d-dcfc-48d8-89c4-4bc9ea51652f", + "image_id": 203929, + "image_name": "12119.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1934.763, + 1994.537, + 1054.75, + 619.9359999999999 + ], + "priority": 15, + "parents": [ + 88266 + ], + "children": [ + 88277 + ], + "area": 3858956.3897309997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 88277, + "strid": "88efc433-d80e-4c38-9211-809d3a6cdebb", + "image_id": 203929, + "image_name": "12119.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2097.405, + 2635.26, + 532.1889999999999, + 36.86799999999994 + ], + "priority": 16, + "parents": [ + 88281 + ], + "children": [], + "area": 5527207.500300001, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3. Funsim score comparison" + }, + { + "id": 88283, + "strid": "d3f7e130-e28a-4005-9a3d-3cd246fe873b", + "image_id": 203929, + "image_name": "12119.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1705.812, + 2707.396, + 1421.5699999999997, + 401.46799999999985 + ], + "priority": 17, + "parents": [ + 88266 + ], + "children": [], + "area": 4618308.585552, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3 compares performance of ESG with PFP’ and the Top PSI-BLAST method using\nsemantic similarity measure2. Among the three methods, ESG has the best average Funsim\nscore at 0.683. With the probability cutoffs of less than 0.35 to select predicted terms, ESG\nshowed a better average Funsim score, but at the same time the number of terms predicted\nwas increased, and hence the precision was dropped. According to Schlicker et al. (2006), the\nFunsim scores in the range of 0.5 to 0.7 indicate that GO terms are functionally related. This\nresult clearly shows that extensive use of information retrieved from PSI-BLAST sequence\nsearch result (by considering very weak hits: ESG and PFP; by extending search space by\niterative database search: ESG; considering GO term association by FAM (Function Association\nMatrix): PFP) significantly contributes in improving function prediction accuracy." + }, + { + "id": 88279, + "strid": "ebcf548b-8d04-4f79-a668-e91fcafe5bcb", + "image_id": 203929, + "image_name": "12119.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3341.087, + 816.663, + 1363.6659999999997, + 562.1669999999999 + ], + "priority": 18, + "parents": [ + 88266 + ], + "children": [ + 88278 + ], + "area": 2728542.132681, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 88278, + "strid": "d345e894-1cee-4ff1-a390-8299e962663b", + "image_id": 203929, + "image_name": "12119.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 3492.475, + 1401.679, + 1056.5809999999997, + 37.374000000000024 + ], + "priority": 19, + "parents": [ + 88279 + ], + "children": [], + "area": 4895328.865525, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 4. Precision and recall for ESG predictions of benchmarking set." + }, + { + "id": 88285, + "strid": "9993f5c4-4be8-4e34-b70b-81443b25ab09", + "image_id": 203929, + "image_name": "12119.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3280.745, + 1466.208, + 1423.5190000000002, + 479.068 + ], + "priority": 20, + "parents": [ + 88266 + ], + "children": [], + "area": 4810254.56496, + "iscrowd": 0, + "segmentation": [], + "text": "In addition to the Funsim score, which evaluates prediction results in the context of GO\nhierarchy, we also computed precision and recall using exact matches with the actual database\nannotations (Fig. 4). ESG shows significantly higher precision of 0.67 (the average across all\norganisms) as compared with those of PFP’ (0.10) and Top PSI-BLAST (0.10). In terms of\nrecall, ESG again shows the best performance over the other two methods for all the genomes\ntested by one (PFP' shows a slightly better performance on the C. elegans dataset). However,\nthe margin of ESG over PFP has shrunken. The average recall for ESG, PFP', and Top PSI-\nBLAST is 0.60, 0.50, and 0.12, respectively. We found that the key advantage of ESG as\ncompared to PFP is the much smaller number of GO terms predicted by ESG (on an average 7)\nas compared to PFP (on an average 60), giving fewer false positives and maintaining high\nprecision value. This narrowing to the minimum set of correct predictions by ESG eliminates\nover predictions and is a main reason for the high Funsim scores shown in Figure 4." + }, + { + "id": 88267, + "strid": "c031f314-f160-4373-9fc2-474b6f7201c4", + "image_id": 203929, + "image_name": "12119.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3273.237, + 2091.976, + 222.91499999999996, + 30.09400000000005 + ], + "priority": 21, + "parents": [ + 88288 + ], + "children": [ + 88286 + ], + "area": 6847533.246312001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 88286, + "strid": "55dcdc1d-f4b6-4afc-b31f-8919060d3d46", + "image_id": 203929, + "image_name": "12119.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3274.363, + 2208.84, + 1413.025, + 399.37699999999995 + ], + "priority": 22, + "parents": [ + 88267 + ], + "children": [], + "area": 7232543.96892, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 88268, + "strid": "4df369ba-923e-4ed6-a818-86fc2f7cf406", + "image_id": 203929, + "image_name": "12119.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3282.999, + 2701.338, + 277.1329999999998, + 31.3420000000001 + ], + "priority": 23, + "parents": [ + 88288 + ], + "children": [ + 88287 + ], + "area": 8868489.952662, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 88287, + "strid": "6160b6a1-7d2b-4ab8-970b-8ed332dbf09b", + "image_id": 203929, + "image_name": "12119.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3265.39, + 2826.423, + 1439.002, + 356.866 + ], + "priority": 24, + "parents": [ + 88268 + ], + "children": [], + "area": 9229373.399969999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 88284, + "strid": "862b21b1-d1c5-4780-b209-d952cc209269", + "image_id": 203929, + "image_name": "12119.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3287.398, + 3317.456, + 1408.7110000000002, + 158.587 + ], + "priority": 25, + "parents": [ + 88288 + ], + "children": [], + "area": 10905798.219488, + "iscrowd": 0, + "segmentation": [], + "text": "ACKNOWLEDGEMENTS\n\nThis work was supported in part by the National Institute of General Medical Sciences of the\n\nNational Institutes of Health (GM075004 and GM077905) and the National Science Foundation\n(DMS 0604776)." + }, + { + "id": 18094, + "strid": "6f7536db-d2fc-4255-a803-d17c04d6950d", + "image_id": 201212, + "image_name": "116768.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 1603.11, + 309.11, + 257.3100000000002, + 85.76999999999998 + ], + "priority": -1, + "parents": [], + "children": [ + 18058, + 18092, + 18056, + 18057, + 18054, + 18055 + ], + "area": 495537.3321, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 18054, + "strid": "026d926e-3d24-4ab2-bab3-f2b773a43df6", + "image_id": 201212, + "image_name": "116768.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 75.062, + 66.084, + 1792.682, + 186.832 + ], + "priority": 1, + "parents": [ + 18094 + ], + "children": [], + "area": 4960.397208, + "iscrowd": 0, + "segmentation": [], + "text": "A Shape-based Approach to Biomodels: an _.\nExample for the Bone Remodelling Workbenc" + }, + { + "id": 18055, + "strid": "dd1ec054-1268-429e-b88a-78b5419e00d6", + "image_id": 201212, + "image_name": "116768.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 78.393, + 292.994, + 1124.588, + 97.50799999999998 + ], + "priority": 2, + "parents": [ + 18094 + ], + "children": [], + "area": 22968.678642000003, + "iscrowd": 0, + "segmentation": [], + "text": "Nicola Paoletti | ela Merelli | Luca Tesei - (Om\nSchool of Scie d Technology — CS division — University of Camerino" + }, + { + "id": 18056, + "strid": "d4ba9a57-da1f-4c51-8862-b74e0ce18191", + "image_id": 201212, + "image_name": "116768.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 67.303, + 451.494, + 734.951, + 58.661 + ], + "priority": 3, + "parents": [ + 18094 + ], + "children": [ + 18059, + 18088, + 18060 + ], + "area": 30386.900682, + "iscrowd": 0, + "segmentation": [], + "text": "Background and Motivation" + }, + { + "id": 18059, + "strid": "f1ebbcd5-6090-47a5-baf5-598024fbe871", + "image_id": 201212, + "image_name": "116768.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 66.278, + 545.509, + 2222.627, + 169.83400000000006 + ], + "priority": 4, + "parents": [ + 18056 + ], + "children": [], + "area": 36155.245502000005, + "iscrowd": 0, + "segmentation": [], + "text": "Recently, computational methods in biology and biomedicine started to consider spatial aspects of biological entities such as the position, an interaction radius or a physical shape.\nIndeed, physical and spatial aspects of biological entities cannot be neglected. However, such systems can exhibit features hard to capture with classical quantitative\nobservables [4]. Interactions and collective functions can be driven not only by quantitative features (e.g., space and geometry), but also by higher-level, more abstract,\n\nqualitative relations, not directly expressible by the “natural” space-driven interactions." + }, + { + "id": 18060, + "strid": "a4c414a7-2a1d-478f-b8c4-db1c534fb804", + "image_id": 201212, + "image_name": "116768.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 66.092, + 730.753, + 1737.506, + 311.13199999999995 + ], + "priority": 5, + "parents": [ + 18056 + ], + "children": [], + "area": 48296.927276, + "iscrowd": 0, + "segmentation": [], + "text": "Therefore, a generalization is possible of the ways by which interactions among entities can be modelled, a concept that unifies the\ntreatment of quantitative and qualitative interactions. We define a formal language where processes are embedded in a\ngeneralized shape that, by means of a more general non-metrical notion of neighbourhood, regulates their communications and\ninteractions, so lifting the geometrical space to a more abstract level. Being so general, this concept of shape proves to be able to express\nclassical process algebras, as well as quantitative extensions of them. Further, we compare the expressiveness and the capabilities of the\nnew shape-based approach w.r.t. more common techniques in computational biology, by using as a workbench the process of bone\nremodelling (BR), a case study of high clinical and biological relevance." + }, + { + "id": 18088, + "strid": "021b76b5-7b47-44f6-bf7d-a9232b3d1acd", + "image_id": 201212, + "image_name": "116768.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1829.906, + 726.033, + 455.096, + 261.014 + ], + "priority": 6, + "parents": [ + 18056 + ], + "children": [ + 18087 + ], + "area": 1328572.142898, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 18087, + "strid": "77005557-2d53-4fbb-a649-14de718ec720", + "image_id": 201212, + "image_name": "116768.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1839.687, + 996.794, + 435.654, + 55.91700000000003 + ], + "priority": 7, + "parents": [ + 18088 + ], + "children": [], + "area": 1833788.963478, + "iscrowd": 0, + "segmentation": [], + "text": "Figure |. Expressiveness of the shape-\nbased process algebra w.r-t. classical ones." + }, + { + "id": 18057, + "strid": "237ab306-fed3-4f52-aa2a-57e1662ad344", + "image_id": 201212, + "image_name": "116768.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 65.807, + 1103.39, + 613.274, + 62.36999999999989 + ], + "priority": 8, + "parents": [ + 18094 + ], + "children": [ + 18063, + 18089, + 18090, + 18091, + 18062, + 18093, + 18061, + 18068, + 18064, + 18069 + ], + "area": 72610.78573, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 18090, + "strid": "c9dd6ecc-0441-410f-8ed3-3d22f8f8b727", + "image_id": 201212, + "image_name": "116768.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 99.125, + 1228.784, + 182.49, + 32.221000000000004 + ], + "priority": 9, + "parents": [ + 18057 + ], + "children": [], + "area": 121803.214, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 18091, + "strid": 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0, + "segmentation": [], + "text": "Actions: AS Mx{open, closed, RANKL}, s.t.an action a=(p, |) contains a position\np in a metric space M and a label | describing the biological function of the\nprocess: open if the canals with other osteocytes are open, closed in case of\nmicro-fracture, or RANKL if the osteocyte is producing RANKL." + }, + { + "id": 18063, + "strid": "75dfa761-7d56-44d2-bab0-4559a85f629b", + "image_id": 201212, + "image_name": "116768.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 107.413, + 2173.741, + 990.5629999999999, + 232.67000000000007 + ], + "priority": 17, + "parents": [ + 18057 + ], + "children": [], + "area": 233488.042033, + "iscrowd": 0, + "segmentation": [], + "text": "Structure: S=(A,T) is defined by fixing a perception radius r&R*.The set T is\ncomposed by the collection of sets\n\n{ b=(p,,|,) =A | d(p,, p,).’, although evidence‘is\nmissing to recommend any different strategy of iron\nadministration’.\n\nThe primary objective of this study wasto-assess\nthe impact on ERI of a frequent fixed low dose of\niron sucrose in prevalent HD patients.\n\nThe secondary objectives wereto describe i.v. iron\nand ESA consumption and\\global anemia drug\nexpenditure." + }, + { + "id": 70109, + "strid": "c99a546a-bd7a-4d4f-816b-0a1f895eccd6", + "image_id": 203239, + "image_name": "119923.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2176.433, + 960.579, + 364.44399999999996, + 56.88099999999997 + ], + "priority": 6, + "parents": [ + 70133 + ], + "children": [ + 70116, + 70115, + 70132 + ], + "area": 2090635.8347069998, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 70115, + "strid": "1ebad2b4-8e30-4b87-9f8a-0b59a393b3fb", + "image_id": 203239, + "image_name": "119923.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1411.271, + 1124.013, + 1942.608, + 261.88699999999994 + ], + "priority": 7, + "parents": [ + 70109 + ], + "children": [], + "area": 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Iron sucrose used was Venofer®." + }, + { + "id": 70110, + "strid": "40cfec35-4e01-4ea0-8083-b67f3f489cdf", + "image_id": 203239, + "image_name": "119923.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1435.948, + 2401.979, + 321.672, + 60.57499999999982 + ], + "priority": 10, + "parents": [ + 70133 + ], + "children": [ + 70127, + 70129, + 70130, + 70123, + 70125, + 70117, + 70118, + 70126, + 70121, + 70119, + 70131, + 70128, + 70120 + ], + "area": 3449116.941092, + "iscrowd": 0, + "segmentation": [], + "text": "RESULTS" + }, + { + "id": 70117, + "strid": "a69ef97d-3a6d-4414-8e00-9934ba4524bc", + "image_id": 203239, + "image_name": "119923.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 42.917, + 2518.304, + 3406.532, + 91.40200000000004 + ], + "priority": 11, + "parents": [ + 70110 + ], + "children": [], + "area": 108078.05276800001, + "iscrowd": 0, + "segmentation": [], + "text": "Of 219 patients at,the centre, 57 patients were eligible and started a fixed dose‘’ef 10mg if i.v. iron sucrose thrice-weekly. 6 patients were\\excluded of final analysis because of death (1), transplants(1), oncological disease\nrequiring radiotherapy (3) or prolonged absence to dialysis (1), leaving 51 patients." + }, + { + "id": 70126, + "strid": "faf535fa-c12d-4465-aaf4-8fa67ae72cd8", + "image_id": 203239, + "image_name": "119923.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 131.701, + 2733.792, + 739.794, + 333.72699999999986 + ], + "priority": 12, + "parents": [ + 70110 + ], + "children": [], + "area": 360043.14019199996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 70127, + "strid": "c8009075-4d00-4bc1-9b01-76ae69de723d", + "image_id": 203239, + "image_name": "119923.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1126.636, + 2766.869, + 470.20600000000013, + 314.17700000000013 + ], + "priority": 13, + "parents": [ + 70110 + ], + "children": [], + "area": 3117254.222684, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 70119, + "strid": "2641a3db-ca3d-4c2e-8357-f605f8402e24", + "image_id": 203239, + "image_name": "119923.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1149.853, + 3141.363, + 459.89699999999993, + 80.85500000000002 + ], + "priority": 14, + "parents": [ + 70110 + ], + "children": [], + "area": 3612105.669639, + "iscrowd": 0, + "segmentation": [], + "text": "Mean Hb levels (g/dL) during baseline period\n(10,9 + 0,70) did not differ from the study*period\n(11,05 + 0,59), p=0.061." + }, + { + "id": 70128, + "strid": "3a239d71-c1be-416a-9801-2fb01d41c614", + "image_id": 203239, + "image_name": "119923.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1818.068, + 2714.813, + 848.5000000000002, + 453.2669999999998 + ], + "priority": 15, + "parents": [ + 70110 + ], + "children": [], + "area": 4935714.641284, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 70120, + "strid": "77937f50-74d1-4183-9d81-db3692f9587c", + "image_id": 203239, + "image_name": "119923.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1874.072, + 3204.894, + 613.0760000000002, + 51.82999999999993 + ], + "priority": 16, + "parents": [ + 70110 + ], + "children": [], + "area": 6006202.108367999, + "iscrowd": 0, + "segmentation": [], + "text": "ERI decreased from 6,169 (IQR 4,29-9,88) to 4,468,dQR 3,01-6,03,\np<0.001)." + }, + { + "id": 70129, + "strid": "7300650a-5bfd-424e-a39b-4f6ad7668567", + "image_id": 203239, + "image_name": "119923.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2794.457, + 2777.992, + 534.6700000000001, + 331.3649999999998 + ], + "priority": 17, + "parents": [ + 70110 + ], + "children": [], + "area": 7762979.190344, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 70121, + "strid": "3e82c1f7-325b-4117-a8d9-9144d4735f71", + "image_id": 203239, + "image_name": "119923.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2777.94, + 3149.173, + 644.846, + 52.34900000000016 + ], + "priority": 18, + "parents": [ + 70110 + ], + "children": [], + "area": 8748213.64362, + "iscrowd": 0, + "segmentation": [], + "text": "The median dose of ESA per patient per month also decreased “from 90\nHg (IQR 65 - 142.5 ) to 70 wg (IQR 46,7 - 90, p<0.001)!" + }, + { + "id": 70125, + "strid": "f78dcb4b-6ee1-4277-98d8-773f5f512cab", + "image_id": 203239, + "image_name": "119923.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 145.198, + 3357.637, + 859.579, + 272.9200000000001 + ], + "priority": 19, + "parents": [ + 70110 + ], + "children": [], + "area": 487522.17712600005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 70123, + "strid": "65016173-8b15-4054-91e3-4605e93b4685", + "image_id": 203239, + "image_name": "119923.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 204.565, + 3662.126, + 611.336, + 51.715999999999894 + ], + "priority": 20, + "parents": [ + 70110 + ], + "children": [], + "area": 749142.80519, + "iscrowd": 0, + "segmentation": [], + "text": "Mean ferritin did not differ, but TSAT at the end w:\nhigher , probably meaning a more efficient use of iron." + }, + { + "id": 70131, + "strid": "47e6c228-40c9-4b23-ae2e-e38111d243f5", + "image_id": 203239, + "image_name": "119923.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1109.842, + 3381.378, + 620.9929999999999, + 353.57699999999977 + ], + "priority": 21, + "parents": [ + 70110 + ], + "children": [], + "area": 3752795.3222760004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 70130, + "strid": "b19c27b9-3a30-4d4c-a816-4c3c54ec46f8", + "image_id": 203239, + "image_name": "119923.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1902.36, + 3365.843, + 778.4970000000001, + 394.43899999999985 + ], + "priority": 22, + "parents": [ + 70110 + ], + "children": [], + "area": 6403045.08948, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 70118, + "strid": "f6acbe33-92d9-4ce1-b0c8-90db82ce7ed4", + "image_id": 203239, + "image_name": "119923.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2787.872, + 3509.382, + 655.261, + 108.55999999999995 + ], + "priority": 23, + "parents": [ + 70110 + ], + "children": [], + "area": 9783707.815104, + "iscrowd": 0, + "segmentation": [], + "text": "At the time of the,study, the public cost of 100mg i.v. iron was 12.26\n€/ampoule and\\darbepoetin was 1.344 €/g. The mean total monthly cost\nof anemia treatment per patient decreased by 25%, from 146 € during\nbaselineto 110 € during the period study." + }, + { + "id": 70111, + "strid": "7a0c0027-9488-4e69-a0e6-e285c94ba351", + "image_id": 203239, + "image_name": "119923.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 491.998, + 3987.034, + 520.223, + 53.51299999999992 + ], + "priority": 24, + "parents": [ + 70133 + ], + "children": [ + 70122 + ], + "area": 1961612.753932, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 70122, + "strid": "5fe41b47-fd5e-4b43-8428-11a6cfefff95", + "image_id": 203239, + "image_name": "119923.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 176.748, + 4222.385, + 1140.173, + 593.46 + ], + "priority": 25, + "parents": [ + 70111 + ], + "children": [], + "area": 746298.10398, + "iscrowd": 0, + "segmentation": [], + "text": "Administration of less but more frequent iron\nallowedcachieving target Hb, improving ESA\nresponse and reducing global costs.\n\nBésides using 36% less iron than before, there was\na significant 22% reduction in ESA’s dose,\nsuggesting an improvement in erythropoiesis.\nAdministration of a low dose ofaror sucrose thrice\nweekly in HD patients shouldbe addressed in\nprospective randomised trials?" + }, + { + "id": 70112, + "strid": "bb312d04-e245-49e6-8833-2d2b7bcf6dc5", + "image_id": 203239, + "image_name": "119923.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2309.044, + 3993.138, + 479.28899999999976, + 55.38700000000017 + ], + "priority": 26, + "parents": [ + 70133 + ], + "children": [ + 70124 + ], + "area": 9220331.340071999, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 70124, + "strid": "496abe65-8037-4d29-84e0-b08687b53f96", + "image_id": 203239, + "image_name": "119923.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1959.283, + 4189.79, + 1289.962, + 761.4809999999998 + ], + "priority": 27, + "parents": [ + 70112 + ], + "children": [], + "area": 8208984.3205699995, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 25281, + "strid": "7a18df92-4daa-410b-982b-a8aab0666261", + "image_id": 201510, + "image_name": "117233.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 276.76, + 45.97, + 81.09000000000003, + 79.19 + ], + "priority": -1, + "parents": [], + "children": [ + 25274, + 25265, + 25276, + 25272, + 25278, + 25266, + 25264, + 25269 + ], + "area": 12722.6572, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 25264, + "strid": "726e46eb-096e-4ebe-ba9f-a8c9611a30db", + "image_id": 201510, + "image_name": "117233.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 434.546, + 53.611, + 768.143, + 53.153 + ], + "priority": 1, + "parents": [ + 25281 + ], + "children": [], + "area": 23296.445605999997, + "iscrowd": 0, + "segmentation": [], + "text": "Stereoscopy> benefits processing of dynamic visual scenes\nby disambiguating object occlusions" + }, + { + "id": 25265, + "strid": "8cb55e9f-3c2c-470f-9c5d-69b606b653c9", + "image_id": 201510, + "image_name": "117233.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 541.994, + 111.908, + 554.389, + 40.57899999999999 + ], + "priority": 2, + "parents": [ + 25281 + ], + "children": [], + "area": 60653.464552000005, + "iscrowd": 0, + "segmentation": [], + "text": "Jocelyn Faubert & Remy Allard\n\nFe ae ae ee ee ee oe" + }, + { + "id": 25266, + "strid": "56135c0a-dee3-4d1e-939c-23369975ecdd", + "image_id": 201510, + "image_name": "117233.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 85.434, + 235.079, + 95.03400000000002, + 14.22999999999999 + ], + "priority": 3, + "parents": [ + 25281 + ], + "children": [ + 25267, + 25268 + ], + "area": 20083.739286, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 25267, + "strid": "1bf3fcbe-46c1-4256-b7f7-988b4a2ac7a3", + "image_id": 201510, + "image_name": "117233.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 83.766, + 258.142, + 725.461, + 44.353999999999985 + ], + "priority": 4, + "parents": [ + 25266 + ], + "children": [], + "area": 21623.522772, + "iscrowd": 0, + "segmentation": [], + "text": "Although the sensation of depth from stereoscopy in real-life contexts can be, on the phenomenological level.quite powerful (Sacks,\n2006) the extent of its functional benef remains elusive. Stereoscopy can improve multiple object tracking (MOT) (Viswanathan and\nMirigolla, 2002: Tinjust, Allard & Faubert, 2008), but the nature of this advantage remains undetermined?" + }, + { + "id": 25268, + "strid": "66638698-eda7-4e05-bc0f-fdf0bf0d808f", + "image_id": 201510, + "image_name": "117233.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 84.982, + 328.623, + 449.616, + 76.55599999999998 + ], + "priority": 5, + "parents": [ + 25266 + ], + "children": [], + "area": 27927.039785999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 25269, + "strid": "6519f6df-e655-411d-8864-8a849dfffe10", + "image_id": 201510, + "image_name": "117233.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 82.658, + 465.75, + 60.354, + 17.146000000000015 + ], + "priority": 6, + "parents": [ + 25281 + ], + "children": [ + 25271, + 25270 + ], + "area": 38497.9635, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 25270, + "strid": "32941cf9-92b7-456c-967e-5509a0b5fd4b", + "image_id": 201510, + "image_name": "117233.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 92.688, + 499.943, + 704.699, + 335.475 + ], + "priority": 7, + "parents": [ + 25269 + ], + "children": [], + "area": 46338.716784, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 25271, + "strid": "5fa94922-939b-4ca7-a993-9ed3879bef77", + "image_id": 201510, + "image_name": "117233.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 83.273, + 878.676, + 651.55, + 117.279 + ], + "priority": 8, + "parents": [ + 25269 + ], + "children": [], + "area": 73169.986548, + "iscrowd": 0, + "segmentation": [], + "text": "Without occlusions: Pair of spheres oscillated along the radial, meridian and depth axes in the 3D virlual space.\nWith occlusions: Pair of spheres oscillated along the meridian and depth axes (but not radial axis)in the 2D virtual space.\nEach occlusion condition was tested with and without stereoscopic cues.\n\nIn a trial, 4 target spheres are indexed (1 for each pair) and the task is to recall all 4 targets at the end of the trial\n\nTrial is considered successful only fall 4 target spheres are correctly identified\n\nA1 up 1 down staircase was Used to obtain speed thresholds." + }, + { + "id": 25278, + "strid": "a83cb5bf-4953-4c4a-8146-62d9141ea739", + "image_id": 201510, + "image_name": "117233.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 872.232, + 214.599, + 58.899, + 15.056999999999988 + ], + "priority": 9, + "parents": [ + 25281 + ], + "children": [ + 25280, + 25279 + ], + "area": 187180.11496799998, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 25279, + "strid": "ddff7a92-5e28-4467-bc96-333f116df08f", + "image_id": 201510, + "image_name": "117233.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 917.541, + 272.701, + 271.56499999999994, + 320.131 + ], + "priority": 10, + "parents": [ + 25278 + ], + "children": [], + "area": 250214.34824100003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 25280, + "strid": "24c1b2a3-2cd4-414d-aefd-916e9fd789cf", + "image_id": 201510, + "image_name": "117233.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1253.35, + 303.078, + 306.88300000000004, + 268.75199999999995 + ], + "priority": 11, + "parents": [ + 25278 + ], + "children": [], + "area": 379862.81129999994, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 25276, + "strid": "c98b7e36-0863-419f-bcc2-ce4d71a3e69f", + "image_id": 201510, + "image_name": "117233.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 871.407, + 668.828, + 214.77599999999995, + 17.54499999999996 + ], + "priority": 12, + "parents": [ + 25281 + ], + "children": [ + 25277 + ], + "area": 582821.400996, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion and Conclusion" + }, + { + "id": 25277, + "strid": "040fad1b-7b7c-420d-9576-2bd288bc95df", + "image_id": 201510, + "image_name": "117233.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 870.802, + 694.238, + 755.043, + 64.73500000000001 + ], + "priority": 13, + "parents": [ + 25276 + ], + "children": [], + "area": 604543.838876, + "iscrowd": 0, + "segmentation": [], + "text": "Overall benefit of stereoscopy for processing dynamic scenes comes from improved attention tracking by disambiguating targets from non-\ntargets during occlusions.\n\nOur results suggest that the use ‘of stereoscopy will provide a more representative measure of visual scene dynamics processing capacities\nwhen interactions between elements occur (Faubert, 2013; Faubert & Sidebottom, 2012)." + }, + { + "id": 25274, + "strid": "9639f0d5-00ae-42f1-b0cd-7e2bd919f766", + "image_id": 201510, + "image_name": "117233.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 872.01, + 823.925, + 88.769, + 14.876999999999953 + ], + "priority": 14, + "parents": [ + 25281 + ], + "children": [ + 25275 + ], + "area": 718470.83925, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 25275, + "strid": "c31f9138-0e50-4e01-82e5-bba89f4e43d5", + "image_id": 201510, + "image_name": "117233.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 871.514, + 856.159, + 716.1050000000001, + 61.99000000000001 + ], + "priority": 15, + "parents": [ + 25274 + ], + "children": [], + "area": 746154.554726, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 25272, + "strid": "cbe30cca-944f-4fa8-b07e-0df3c8d50382", + "image_id": 201510, + "image_name": "117233.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 871.636, + 979.631, + 144.02700000000004, + 18.615999999999985 + ], + "priority": 16, + "parents": [ + 25281 + ], + "children": [ + 25273 + ], + "area": 853881.6463159999, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgments" + }, + { + "id": 25273, + "strid": "01589e77-5eb2-4a3c-944b-347f0cf73d83", + "image_id": 201510, + "image_name": "117233.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 871.147, + 1012.944, + 509.48300000000006, + 17.145999999999958 + ], + "priority": 17, + "parents": [ + 25272 + ], + "children": [], + "area": 882423.126768, + "iscrowd": 0, + "segmentation": [], + "text": "This research was supported by an NSERC discovery fund to Jocelyn Faubert." + }, + { + "id": 95245, + "strid": "8d582c77-e9fd-422f-88f2-5dc2293d896d", + "image_id": 204180, + "image_name": "121591.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 183.46, + 91.82, + 375.4599999999999, + 301.72 + ], + "priority": -1, + "parents": [], + "children": [ + 95230, + 95233, + 95231, + 95229, + 95232, + 95238, + 95228, + 95242 + ], + "area": 16845.2972, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 95228, + "strid": "69ef2b39-dce8-4dc7-81c4-1643673796c0", + "image_id": 204180, + "image_name": "121591.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 686.137, + 41.526, + 3706.3320000000003, + 431.219 + ], + "priority": 1, + "parents": [ + 95245 + ], + "children": [], + "area": 28492.525062, + "iscrowd": 0, + "segmentation": [], + "text": "eS en mean\n\naise = hab fi}) ia West. ; ij" + }, + { + "id": 95242, + "strid": "d9f9efdd-2ebe-4292-88fc-b0da84b70e42", + "image_id": 204180, + "image_name": "121591.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1706.105, + 261.331, + 648.8589999999999, + 314.539 + ], + "priority": 2, + "parents": [ + 95245 + ], + "children": [], + "area": 445858.12575500004, + "iscrowd": 0, + "segmentation": [], + "text": "| dia\nSian'Lomax" + }, + { + "id": 95229, + "strid": "640b1f93-abb3-4f2c-8ae3-5fbd26206195", + "image_id": 204180, + "image_name": "121591.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 942.697, + 509.594, + 378.6329999999999, + 81.78500000000003 + ], + "priority": 3, + "parents": [ + 95245 + ], + "children": [ + 95234 + ], + "area": 480392.735018, + "iscrowd": 0, + "segmentation": [], + "text": "Summary" + }, + { + "id": 95234, + "strid": "80aa9a89-46c5-41e5-ad33-bef7e4fc0561", + "image_id": 204180, + "image_name": "121591.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 169.34, + 618.899, + 1946.814, + 450.93600000000004 + ], + "priority": 4, + "parents": [ + 95229 + ], + "children": [], + "area": 104804.35666, + "iscrowd": 0, + "segmentation": [], + "text": "As passionate practitioners, there can be a tendency to assume that our citizen science projects are an\noverwhelming success, and often our ‘evaluation’ is limited to counting the numbers of participants, taking\nphotographs and selecting nice quotations sent by happy participants to our funders (see West 2015).\nWe conducted a simple evaluation of a citizen science project which looked at both the quality of the data\ncollected and the impact of participation on knowledge and interest in nature. This revealed a significant\nincrease in knowledge after participation, demonstrating the effectiveness of the survey as an educational\ntool. However, there were some discrepancies between data collected by the participants and a trained\nscientist. Recommendations are made for how to improve the quality of the results obtained through\ncitizen science projects and the learning experience for participants." + }, + { + "id": 95231, + "strid": "600f413a-601e-454c-a1b3-98e3ec94812f", + "image_id": 204180, + "image_name": "121591.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 668.425, + 1346.016, + 918.9100000000001, + 81.298 + ], + "priority": 5, + "parents": [ + 95245 + ], + "children": [ + 95239, + 95244 + ], + "area": 899710.7448, + "iscrowd": 0, + "segmentation": [], + "text": "Evaluation is important" + }, + { + "id": 95244, + "strid": "d7936652-0b41-4cf6-a03c-4b75a8e10da6", + "image_id": 204180, + "image_name": "121591.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 84.671, + 1461.64, + 2067.305, + 632.6340000000002 + ], + "priority": 6, + "parents": [ + 95231 + ], + "children": [], + "area": 123758.52044000002, + "iscrowd": 0, + "segmentation": [], + "text": "Citizen science projects have the potential to both advance scientific knowledge and provide benefits for\nparticipants. One of the big challenges for citizen science is to develop projects which are inclusive and\naccessible for participants, but also deliver high quality data. Evaluation offers a way of assessing whether\nproject aims have been met, and lessons learned from evaluations can help inform the design of future projects.\n\nIntroducing the OPAL Soil and Earthworm Survey\n\nOPAL is a UK-wide citizen science programme which aims to allow people of all ages and from all backgrounds\nto explore their local environment, whilst collecting data about the state of the environment. As part of the OPAL\nprogramme, seven national surveys were created, one of which was the Soil and Earthworm Survey. The aims o\nthe survey were to:" + }, + { + "id": 95239, + "strid": "2aa2bb1b-a441-4791-9ecb-65f0ffda9507", + "image_id": 204180, + "image_name": "121591.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 124.723, + 2111.998, + 1992.1530000000002, + 296.08100000000013 + ], + "priority": 7, + "parents": [ + 95231 + ], + "children": [], + "area": 263414.726554, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 95232, + "strid": "1b0eae94-1a92-4f4f-ae7c-080baa86b6db", + "image_id": 204180, + "image_name": "121591.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 103.466, + 2626.054, + 2057.86, + 90.42799999999988 + ], + "priority": 8, + "parents": [ + 95245 + ], + "children": [ + 95241, + 95235 + ], + "area": 271707.303164, + "iscrowd": 0, + "segmentation": [], + "text": "We evaluated data quality and participant outcomes" + }, + { + "id": 95241, + "strid": "8ce1aee3-84d4-44a8-bb5f-1e1aa5539bc3", + "image_id": 204180, + "image_name": "121591.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 91.33, + 2750.189, + 1987.505, + 222.64399999999978 + ], + "priority": 9, + "parents": [ + 95232 + ], + "children": [], + "area": 251174.76137, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 95235, + "strid": "52e11da4-e22b-47eb-9093-a549d3be2b2a", + "image_id": 204180, + "image_name": "121591.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 95.011, + 3019.456, + 2078.551, + 246.82799999999997 + ], + "priority": 10, + "parents": [ + 95232 + ], + "children": [], + "area": 286881.534016, + "iscrowd": 0, + "segmentation": [], + "text": "87 participants in York (UK) ranging in age between 5 and 60+ took part in the research. They listened to a\n\nshort talk about soil and earthworms and then completed the Soil and Earthworm Survey. Soil samples and\nearthworms were then taken back to the laboratory and re-analysed using the same or more advanced methods.\nBefore, immediately after and three months after the workshop, participants completed a questionnaire to assess\ntheir knowledge of soil and earthworms, interest in spending time outdoors and interest in nature." + }, + { + "id": 95233, + "strid": "52ca4f29-3e5d-49c5-bfed-ba08a4e3d900", + "image_id": 204180, + "image_name": "121591.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 966.438, + 3369.176, + 340.82000000000005, + 85.83599999999979 + ], + "priority": 11, + "parents": [ + 95245 + ], + "children": [ + 95236 + ], + "area": 3256099.715088, + "iscrowd": 0, + "segmentation": [], + "text": "Findings" + }, + { + "id": 95236, + "strid": "cf57ed81-2770-4b40-96ee-a4cbbcc6bf8e", + "image_id": 204180, + "image_name": "121591.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 95.805, + 3501.594, + 2051.507, + 923.6130000000003 + ], + "priority": 12, + "parents": [ + 95233 + ], + "children": [], + "area": 335470.21317, + "iscrowd": 0, + "segmentation": [], + "text": "People weren’t particularly good at identifying earthworms!\n\nParticipants counted total number of earthworms, recorded if they were mature or immature, and identified\nmature worms using a key to 13 common species. The researcher used the same key, a more detailed key and\na stereo microscope.\n\n107 earthworms were identified to species level\n39% identified correctly\n\n46% correctly identified,assimmature\n\n57% adults identified at least 1 earthworm correctly\ncompared with’'42% children.\n\nThey are even worse at identifying soil texture\n\nParticipants and researcher used a hand-texture chart. Only 29% participants correctly\nidentified the texture of their soil samples" + }, + { + "id": 95230, + "strid": "b38e2959-c0f5-49d2-a63d-a7ba6737b59b", + "image_id": 204180, + "image_name": "121591.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2913.399, + 540.797, + 1393.4850000000001, + 81.769 + ], + "priority": 13, + "parents": [ + 95245 + ], + "children": [ + 95243, + 95237, + 95240 + ], + "area": 1575557.439003, + "iscrowd": 0, + "segmentation": [], + "text": "How can data quality be improved?" + }, + { + "id": 95237, + "strid": "d86a42c7-2793-48fc-9645-3ed80a51d925", + "image_id": 204180, + "image_name": "121591.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2543.013, + 666.97, + 2121.46, + 959.9359999999999 + ], + "priority": 14, + "parents": [ + 95230 + ], + "children": [], + "area": 1696113.38061, + "iscrowd": 0, + "segmentation": [], + "text": "ID to species level was challenging, especially without help of trained group leader. Think about whether you need\nto ID to species, or if a higher level is sufficient.\n\nTest materials with all groups the survey is aimed at (e.g. different age ranges, levels of previous experience, with\nleader and without). Verify records using photographs, and make submission easy (e.g. app).\n\nBut people learnt things and had a good time!\n\nThe majority of participants:\nEnjoyed the workshop\nWould like to take part in similar activities in the future\nFelt they had learnt something from taking part\n\nKnowledge increased between pre- and post-workshop questionnaires, but decreased to the three month post-\nworkshop questionnaire, although it remained higher than the pre- workshop levels." + }, + { + "id": 95240, + "strid": "ce4bae8f-365e-4d99-bf53-93bfa97d06bd", + "image_id": 204180, + "image_name": "121591.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2739.774, + 1705.273, + 1596.8650000000002, + 881.0289999999998 + ], + "priority": 15, + "parents": [ + 95230 + ], + "children": [], + "area": 4672062.6283019995, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 95243, + "strid": "4eab4e51-41ea-4c2b-8352-b9a2d8665cf8", + "image_id": 204180, + "image_name": "121591.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2544.18, + 2654.066, + 2122.247, + 454.2869999999998 + ], + "priority": 16, + "parents": [ + 95230 + ], + "children": [], + "area": 6752421.635879999, + "iscrowd": 0, + "segmentation": [], + "text": "Desire to take part in outdoor activities increased between pre- and post- workshop questionnaires but had been\n\nlost three months after the workshop.\nParticipants’ interest in nature showed no difference between questionnaires, but their level of interest already high.\n\nHow can we improve participant outcomes?\n\nPre- or post- survey activities can improve knowledge retention (Stern et al. 2008).\nTarget groups less engaged if you want to achieve greater changes." + }, + { + "id": 95238, + "strid": "43dd8698-13b9-41c6-a0e3-93716b8f6424", + "image_id": 204180, + "image_name": "121591.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2628.778, + 3346.242, + 1770.6060000000002, + 349.4229999999998 + ], + "priority": 17, + "parents": [ + 95245 + ], + "children": [], + "area": 8796527.352276, + "iscrowd": 0, + "segmentation": [], + "text": "| and Mone\n: Build in'time\naks\naac\n\ney\nree} nn\n\nNK\n\n#7" + }, + { + "id": 175965, + "strid": "c97940d8-2709-4408-b41e-fcc6bd30459d", + "image_id": 207368, + "image_name": "7489.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 127.38, + 399.96, + 292.05, + 146.02000000000004 + ], + "priority": -1, + "parents": [], + "children": [ + 175924, + 175918, + 175923, + 175920, + 175919, + 175963, + 175921, + 175922 + ], + "area": 50946.9048, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 175918, + "strid": "6367cea3-7d2c-4f9f-affa-273f3d5746b9", + "image_id": 207368, + "image_name": "7489.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 247.366, + 274.62, + 2815.721, + 248.95899999999995 + ], + "priority": 1, + "parents": [ + 175965 + ], + "children": [], + "area": 67931.65092, + "iscrowd": 0, + "segmentation": [], + "text": "New insights into novel prognostic biomarkers of\nlongevity in ALS patients" + }, + { + "id": 175919, + "strid": "0951c2a2-1855-4176-878f-2353fda0697e", + "image_id": 207368, + "image_name": "7489.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 120.386, + 585.456, + 3022.867, + 364.98699999999997 + ], + "priority": 2, + "parents": [ + 175965 + ], + "children": [], + "area": 70480.706016, + "iscrowd": 0, + "segmentation": [], + "text": "Polo-Generelo, S.', Atencia, G.', Calvo, A.C.1:, Juarez-Rufian, A.', Cordero-Vazquez, P.', Martin, M.A.°, Moraleda, J.M.*,\nMartinez-Pérez S.*, Esteban-Pérez, J.', Osta, R.2 and Garcia-Redondo, A.'\n\n‘Neurology department — ALS Unit. CIBERER U-723. Health research Institute, October 12th University Hospital — Avda. Cordoba s/n — 28041 Madrid — Spain.\n2LAGENBIO-I3A, Aragonese Institute of Health Sciences (IACS), Faculty of Veterinary, University of Zaragoza, Miguel Servet, 177. 50013 Zaragoza. Spain.\n\n’ Biochemistry department. CIBERER U-723. Health research Institute, October 12th University Hospital - Avda. Cérdoba s/n — 28041 Madrid — Spain.\n\n4 Hematopoietic transplant Unit and cell Therapy. Hematology department. Virgen de la Arrixaca University Hospital — Ctra. Madrid-Cartagena, s/n — 30120 Murcia — Spain." + }, + { + "id": 175920, + "strid": "4c207f99-1cbb-4a3a-95ac-7007c1c24d5e", + "image_id": 207368, + "image_name": "7489.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 72.751, + 1053.53, + 438.66600000000005, + 71.17599999999993 + ], + "priority": 3, + "parents": [ + 175965 + ], + "children": [ + 175925 + ], + "area": 76645.36103, + "iscrowd": 0, + "segmentation": [], + "text": "Background" + }, + { + "id": 175925, + "strid": "af7e8693-cae4-4236-a7c3-226400197f6e", + "image_id": 207368, + "image_name": "7489.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 111.052, + 1133.109, + 1481.607, + 276.38200000000006 + ], + "priority": 4, + "parents": [ + 175920 + ], + "children": [], + "area": 125834.020668, + "iscrowd": 0, + "segmentation": [], + "text": "Previous studies in our group analyzed expression level of seventeen genes (Ankrd1,\nCalm1, Col19a1, Fbxo32, Gsr, Impa1, Mef2c, Mt2, Myf5, Myod1, Myog, Nnt, Nogo A, Pax7, Rrad,\nSIn and Snx10) in muscle biopsies from the transgenic SOD1G93A mice. Our findings suggested\nfive potential prognostic biomarkers of longevity in this animal model (Mef2c, Gsr, Col19, Calm1 and\nSnx10) [1].\n\nIn spite of the fact that the search of biomarkers in ALS is being carried out in a wide variety\nof patient’s samples, growing tendency relies on the study of new and less invasive tissues [2,3]." + }, + { + "id": 175923, + "strid": "3308fdfc-0432-468d-8712-22ce7fcca5f9", + "image_id": 207368, + "image_name": "7489.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 589.195, + 1518.787, + 340.173, + 71.84699999999998 + ], + "priority": 5, + "parents": [ + 175965 + ], + "children": [ + 175926 + ], + "area": 894861.706465, + "iscrowd": 0, + "segmentation": [], + "text": "Objective" + }, + { + "id": 175926, + "strid": "a3d941fe-d92b-4eb9-8e6d-da9370fc7ce2", + "image_id": 207368, + "image_name": "7489.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 139.536, + 1598.353, + 1241.442, + 87.2159999999999 + ], + "priority": 6, + "parents": [ + 175923 + ], + "children": [], + "area": 223027.784208, + "iscrowd": 0, + "segmentation": [], + "text": "Our main aim is to validate the diagnostic and prognostic capacity of the\nselected genes In human blood samples." + }, + { + "id": 175921, + "strid": "dc3d7dfc-8d81-47e1-a2fe-656a178f0ea3", + "image_id": 207368, + "image_name": "7489.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1702.088, + 1043.588, + 307.7929999999999, + 73.14599999999996 + ], + "priority": 7, + "parents": [ + 175965 + ], + "children": [ + 175961, + 175959, + 175960 + ], + "area": 1776278.6117439999, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 175960, + "strid": "11b73af3-52e2-4381-990d-dfd1abc79911", + "image_id": 207368, + "image_name": "7489.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1740.45, + 1123.893, + 1436.3699999999997, + 112.702 + ], + "priority": 8, + "parents": [ + 175921 + ], + "children": [], + "area": 1956079.5718500002, + "iscrowd": 0, + "segmentation": [], + "text": "cDNA serial samples from lymphocytes of 45 patients from sporadic and familial ALS (29\nmales and 16 females), born between 1941 and 1985, were subjected to qPCR in order to study\nexpression levels of COL19A1, GSR, SNX10, MEF2C and NOGO A. The levels found in every" + }, + { + "id": 175961, + "strid": "85a99fa6-83b3-4451-9173-0327ce762c8a", + "image_id": 207368, + "image_name": "7489.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1741.333, + 1243.452, + 893.607, + 311.95000000000005 + ], + "priority": 9, + "parents": [ + 175921 + ], + "children": [], + "area": 2165264.001516, + "iscrowd": 0, + "segmentation": [], + "text": "sample were related to ALSFRS-r , FVC and survival values.\n\nPatients were classified in 2 groups (with less and\nmore of 5 years of survival from symptoms onset) and the\nsurvival curves resulted between these 2 groups were\nsignificantly different on a Kaplan Meyer study.\n\nExpression data followed a normal distribution, then\nparametric test was used. Statistical analysis was made with\nGraphPad Prism software." + }, + { + "id": 175959, + "strid": "04e2ce77-1e2b-4036-b372-cd66cb5d509f", + "image_id": 207368, + "image_name": "7489.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2671.169, + 1252.934, + 511.1700000000001, + 326.77600000000007 + ], + "priority": 10, + "parents": [ + 175921 + ], + "children": [], + "area": 3346798.4598459997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 175922, + "strid": "b0a67736-6626-4890-948c-a64622839ac6", + "image_id": 207368, + "image_name": "7489.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1701.358, + 1670.546, + 333.57500000000005, + 89.44200000000001 + ], + "priority": 11, + "parents": [ + 175965 + ], + "children": [ + 175940, + 175950, + 175936, + 175952, + 175931, + 175939, + 175953, + 175955, + 175949, + 175928, + 175932, + 175930, + 175951, + 175929, + 175956, + 175944, + 175938, + 175948, + 175945, + 175943, + 175933, + 175937, + 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Out of 100\nstudents, 42 had low SDLR and were provided\nintervention —" + }, + { + "id": 61485, + "strid": "f291a1f3-0752-405f-923c-35e90f9ae43a", + "image_id": 202925, + "image_name": "119459.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1350.179, + 916.781, + 937.9180000000001, + 475.05600000000004 + ], + "priority": 16, + "parents": [ + 61469 + ], + "children": [], + "area": 1237818.453799, + "iscrowd": 0, + "segmentation": [], + "text": "Intervention is called\n\nMedical Online Assessment System (MOAS)\nA structured strategy consisting of graded\ndifficulty questions ( starting from simple recall,\nfollowed by understanding, ability to apply\nbiochemistry in solving case scenarios and\nability to analyse, synthesize, evaluate by\ninterpreting case reports) using online\ntechnology" + }, + { + "id": 61479, + "strid": "5eb51071-0d96-4208-a4cc-b0718590e5e2", + "image_id": 202925, + "image_name": "119459.png", + "category_id": 4, + "category_name": "List", + 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Readiness for SDL exists\nalong a continuum and is present in all individuals to\nsome extent.\n\nStudents who have low readiness for SDL when\nexposed to SDL project exhibit high level of anxiety\nand similarly those learners with high readiness for\nSDL if exposed to increasing levels of teacher\ndirection also exhibit high anxiety level. Since\nreadiness for SDL is individualized, so should be the\namount and type of teacher direction." + }, + { + "id": 61480, + "strid": "0ddb1efe-7934-4bdf-96d3-d2e2a156169c", + "image_id": 202925, + "image_name": "119459.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3660.485, + 1323.541, + 1069.908, + 928.885 + ], + "priority": 34, + "parents": [ + 61473 + ], + "children": [], + "area": 4844801.977385, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61475, + "strid": "5e1ceb71-65b9-4a89-80c4-e0a2b96a82c8", + "image_id": 202925, + "image_name": "119459.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3662.242, + 2335.82, + 265.85300000000007, + 37.26899999999978 + ], + "priority": 35, + "parents": [ + 61509 + ], + "children": [ + 61490 + ], + "area": 8554338.10844, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 61490, + "strid": "43dfc6f4-46f6-4526-a546-0c6d980e04f4", + "image_id": 202925, + "image_name": 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"image_name": "119459.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4060.594, + 2711.988, + 556.6689999999999, + 48.89800000000014 + ], + "priority": 38, + "parents": [ + 61476 + ], + "children": [], + "area": 11012282.200872, + "iscrowd": 0, + "segmentation": [], + "text": "Modify the existing strategy/" + }, + { + "id": 61492, + "strid": "fc173d7f-3eec-486d-9de0-3e0632f14191", + "image_id": 202925, + "image_name": "119459.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3660.467, + 2766.636, + 1049.0899999999997, + 102.42300000000023 + ], + "priority": 39, + "parents": [ + 61476 + ], + "children": [], + "area": 10127179.779012, + "iscrowd": 0, + "segmentation": [], + "text": "Design a separate strategy to facilitate students who\nhave high readiness for Self directed learning" + }, + { + "id": 61477, + "strid": "8804dc89-4c53-4818-9458-dfa8b32e7e24", + "image_id": 202925, + "image_name": "119459.png", + "category_id": 5, + "category_name": 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We provide:" + }, + { + "id": 94400, + "strid": "0a4c08b2-4bc4-4e59-b480-0b9cfafd4e22", + "image_id": 204155, + "image_name": "121536.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3429.291, + 298.538, + 999.3580000000002, + 412.058 + ], + "priority": 7, + "parents": [ + 94409 + ], + "children": [], + "area": 1023773.676558, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 94399, + "strid": "849d56e9-47c1-46f2-a2bc-46bf706c61c6", + "image_id": 204155, + "image_name": "121536.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3380.35, + 780.061, + 1311.953, + 175.24300000000005 + ], + "priority": 8, + "parents": [ + 94409 + ], + "children": [], + "area": 2636879.20135, + "iscrowd": 0, + "segmentation": [], + "text": "Our formative evaluation of the program documents science\nidentity and youth development outcomes attributable to these\nexperiences." + }, + { + "id": 94401, + "strid": "fe4c61bc-1578-4d60-8c42-20f55eb4deb8", + "image_id": 204155, + "image_name": "121536.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3375.613, + 1064.239, + 1223.5430000000001, + 358.3800000000001 + ], + "priority": 9, + "parents": [ + 94409 + ], + "children": [], + "area": 3592459.003507, + "iscrowd": 0, + "segmentation": [], + "text": "science identity: “... becoming and being recognized as a\n‘science person’” (Gee 2001).\n\nyouth development: in terms of key life skills, this is\ncharacterized by “the five Cs” (Leaner et al. 2013),\ncompetence, confidence, character, connection, and caring." + }, + { + "id": 94407, + "strid": "4b46c2f3-d1f0-4dfd-9208-68f85303d124", + "image_id": 204155, + "image_name": "121536.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3408.247, + 1586.148, + 1200.5120000000002, + 853.086 + ], + "priority": 10, + "parents": [ + 94409 + ], + "children": [], + "area": 5405984.162555999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 94408, + "strid": "61d882f4-3fa7-4367-ad77-1ff8daf2a1b0", + "image_id": 204155, + "image_name": "121536.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3404.807, + 2514.911, + 1188.473, + 123.83500000000004 + ], + "priority": 11, + "parents": [ + 94409 + ], + "children": [], + "area": 8562786.577177, + "iscrowd": 0, + "segmentation": [], + "text": "2012: 13 4-H Educators trained in New York\n2013: 85 4-H Educators nationwide, from Alaska to Puerto Rico\n2014: CA, IL, and NY focal states for intensive training, implementation, and evaluation" + }, + { + "id": 94405, + "strid": "bfaba125-4ffa-4dc5-b1cc-2930fdce0fc7", + "image_id": 204155, + "image_name": "121536.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3341.327, + 2800.8, + 1332.6149999999998, + 501.8290000000002 + ], + "priority": 12, + "parents": [ + 94409 + ], + "children": [], + "area": 9358388.661600001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 94406, + "strid": "c4e3887c-127d-4d99-abe4-4bce24655670", + "image_id": 204155, + "image_name": "121536.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3340.086, + 3341.231, + 1325.4649999999997, + 109.89800000000014 + ], + "priority": 13, + "parents": [ + 94409 + ], + "children": [], + "area": 11159998.885866, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements: Funding for this project was provided by two grants from the Noyce Foundation and\nform a Smith-Lever grant. We greatly appreciate the participation of dozens of 4-H educators across the\ncountry in bringing this project to fruition." + }, + { + "id": 84822, + "strid": "51fa965f-152e-4092-9750-de7322b5348a", + "image_id": 203796, + "image_name": "120932.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 74.71, + 60.8, + 262.07, + 238.24 + ], + "priority": -1, + "parents": [], + "children": [ + 84800, + 84799, + 84802, + 84820, + 84818, + 84814, + 84808, + 84801, + 84817 + ], + "area": 4542.3679999999995, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 84799, + "strid": "e3c16d20-b9fa-4bcb-9849-e4494fbcfba8", + "image_id": 203796, + "image_name": "120932.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 1189.352, + 107.309, + 2747.059, + 238.32900000000004 + ], + "priority": 1, + "parents": [ + 84822 + ], + "children": [], + "area": 127628.17376800001, + "iscrowd": 0, + "segmentation": [], + "text": "Cognitive insight and functioning outcomes in cognitive behavioral\nsocial skills training for schizophrenia" + }, + { + "id": 84800, + "strid": "7ca4a074-be7e-4400-be3d-a6b3006d983e", + "image_id": 203796, + "image_name": "120932.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1690.011, + 489.451, + 1687.504, + 172.586 + ], + "priority": 2, + "parents": [ + 84822 + ], + "children": [], + "area": 827177.5739610001, + "iscrowd": 0, + "segmentation": [], + "text": "Ariel Wilson, Jason’Holden, Peter Link, Eric Granholm\nVA San Diego Healthcare System, Dept. of Psychiatry, UCSD" + }, + { + "id": 84817, + "strid": "e5e349c9-ce5d-40f7-8a2c-6d29c9b09994", + "image_id": 203796, + "image_name": "120932.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 195.87, + 789.507, + 394.4150000000001, + 79.755 + ], + "priority": 3, + "parents": [ + 84822 + ], + "children": [ + 84816 + ], + "area": 154640.73609, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 84816, + "strid": "af7dcf90-552b-4615-aded-7abd131abdaa", + "image_id": 203796, + "image_name": "120932.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 163.812, + 897.136, + 1404.7150000000001, + 899.441 + ], + "priority": 4, + "parents": [ + 84817 + ], + "children": [], + "area": 146961.642432, + "iscrowd": 0, + "segmentation": [], + "text": "Cognitive insight in schizophrenia has been recognized as a possible\nmechanism of change in psychosocial treatment. We previously reported that\nconsumers who received cognitive behavioral-social skills training showed\nincreased cognitive insight that was correlated with a greater reduction in\npositive symptoms. However, few studies have focused on the link between\ncognitive insight and recovery outcomes. The current study examined the\nrelationship between change in-cognitive insight (BCIS) and clinical insight\n(BIS), with outcomes at end of treatment in self esteem (SERS), defeatist beliefs\n(DPAS), and everyday functioning (ILSS). 75 consumers were randomized to\neither cognitive behavioral) social skills training or goal-focused supportive\ncontact. An increasé,in-cognitive insight was associated with higher positive self\nesteem at end of treatment for both groups. Improvement in clinical insight was\nassociated withshigher defeatist attitudes at end of treatment, exclusively for the\nGFSC group: Linear regression analyses revealed a significantinteraction\nbetween treatment group and change in one component of cognitive insight\n(self-reflectiveness) on everyday functioning. Such results{suggest that the\neffectof change in cognitive insight (specifically, self-reflectiveness) on everyday\nfunctioning was stronger in CBSST than in GFSC. Additionally, improvement in\nClinical insight alone may not lead to the same beneficial outcomes." + }, + { + "id": 84818, + "strid": "f0ec5333-9002-4ae5-aae5-3a76d8cfc56c", + "image_id": 203796, + "image_name": "120932.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 178.698, + 1803.165, + 547.25, + 92.66000000000008 + ], + "priority": 5, + "parents": [ + 84822 + ], + "children": [ + 84819 + ], + "area": 322221.97917, + "iscrowd": 0, + "segmentation": [], + "text": "Background" + }, + { + "id": 84819, + "strid": "bff02c9c-cb1f-4813-90bf-2b169b9a8711", + "image_id": 203796, + "image_name": "120932.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 145.216, + 1916.235, + 1374.56, + 978.153 + ], + "priority": 6, + "parents": [ + 84818 + ], + "children": [], + "area": 278267.98176, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 84820, + "strid": "149b5f50-9123-49b5-ab3c-d57b1dd63e29", + "image_id": 203796, + "image_name": "120932.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 173.881, + 2908.928, + 387.45400000000006, + 85.53099999999995 + ], + "priority": 7, + "parents": [ + 84822 + ], + "children": [ + 84821 + ], + "area": 505807.30956799997, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 84821, + "strid": "43bbab5d-5e56-45f8-ad3c-1c44b012639c", + "image_id": 203796, + "image_name": "120932.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 135.634, + 3020.787, + 1331.364, + 426.43899999999985 + ], + "priority": 8, + "parents": [ + 84820 + ], + "children": [], + "area": 409721.4239579999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 84801, + "strid": "1f8d7855-e2f1-4355-a88f-4ec27ef5cfb7", + "image_id": 203796, + "image_name": "120932.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1687.581, + 776.024, + 438.64999999999986, + 94.10000000000002 + ], + "priority": 9, + "parents": [ + 84822 + ], + "children": [ + 84815 + ], + "area": 1309603.3579439998, + "iscrowd": 0, + "segmentation": [], + "text": "Measures" + }, + { + "id": 84815, + "strid": "295a07e2-889a-4605-aa34-3fa00bdab423", + "image_id": 203796, + "image_name": "120932.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1691.928, + 897.579, + 1278.0920000000003, + 961.6310000000001 + ], + "priority": 10, + "parents": [ + 84801 + ], + "children": [], + "area": 1518639.042312, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 84814, + "strid": "9da42985-d2d1-4797-8b38-868428bb2632", + "image_id": 203796, + "image_name": "120932.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1688.096, + 1942.514, + 331.17100000000005, + 92.03600000000006 + ], + "priority": 11, + "parents": [ + 84822 + ], + "children": [ + 84810, + 84811, + 84813 + ], + "area": 3279150.1133439997, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 84813, + "strid": "75397fee-4702-453f-b9f5-558d7c0f8173", + "image_id": 203796, + "image_name": "120932.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1673.04, + 2098.341, + 1338.2870000000003, + 336.3609999999999 + ], + "priority": 12, + "parents": [ + 84814 + ], + "children": [], + "area": 3510608.4266399997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 84811, + "strid": "1c413c8d-9459-4004-ae12-b204bf260681", + "image_id": 203796, + "image_name": "120932.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1682.97, + 2707.992, + 1250.6139999999998, + 425.55200000000013 + ], + "priority": 13, + "parents": [ + 84814 + ], + "children": [ + 84812 + ], + "area": 4557469.29624, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 84812, + "strid": "3e6dd2a6-cb1f-4b09-b4a5-2b465a532e42", + "image_id": 203796, + "image_name": "120932.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1693.098, + 2547.796, + 1185.5929999999998, + 78.43899999999985 + ], + "priority": 14, + "parents": [ + 84811 + ], + "children": [], + "area": 4313668.312008, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1: Correlations Between Change in Cognitive Insight and Self Esteenvat\nEnd of Treatment:" + }, + { + "id": 84810, + "strid": "0b196e16-89a3-4edc-acd9-53f0c1694dbe", + "image_id": 203796, + "image_name": "120932.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1651.938, + 3360.92, + 1411.9809999999998, + 140.61799999999994 + ], + "priority": 15, + "parents": [ + 84814 + ], + "children": [], + "area": 5552031.46296, + "iscrowd": 0, + "segmentation": [], + "text": "The research repo eeppre was supported by the Department of Veterans A .\nVeterans Health Ad ration, Rehabilitation Research and he participants ice, and\n\nthe National Insti f Mental Health (MH091057). We thank the participants who\nvolunteered for this.research." + }, + { + "id": 84802, + "strid": "b3104a72-5a08-4317-9064-57d84ab1e276", + "image_id": 203796, + "image_name": "120932.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3215.973, + 775.256, + 598.1930000000002, + 87.00999999999999 + ], + "priority": 16, + "parents": [ + 84822 + ], + "children": [ + 84807, + 84806, + 84804 + ], + "area": 2493202.364088, + "iscrowd": 0, + "segmentation": [], + "text": "Results cant." + }, + { + "id": 84804, + "strid": "14c1bc5a-00f9-4df7-84a9-2d53850d842c", + "image_id": 203796, + "image_name": "120932.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 3216.218, + 1059.561, + 1235.5460000000003, + 486.501 + ], + "priority": 17, + "parents": [ + 84802 + ], + "children": [ + 84803 + ], + "area": 3407779.1602979996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 84803, + "strid": "7db212f4-f3ae-4964-8700-a0e6e7b0cedc", + "image_id": 203796, + "image_name": "120932.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 3216.409, + 922.085, + 1064.0769999999998, + 78.85299999999995 + ], + "priority": 18, + "parents": [ + 84804 + ], + "children": [], + "area": 2965802.492765, + "iscrowd": 0, + "segmentation": [], + "text": "Table 2: Correlations Between Change in Clinical Insight and Defeatist\nPerformance Attitudes at End of Treatment, for GFSC and CBSST." + }, + { + "id": 84806, + "strid": "7fb7dea8-dded-4d31-85e7-aeaaeae2e834", + "image_id": 203796, + "image_name": "120932.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 3216.852, + 1758.424, + 1241.6989999999996, + 568.029 + ], + "priority": 19, + "parents": [ + 84802 + ], + "children": [ + 84805 + ], + "area": 5656589.761248, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 84805, + "strid": "a8bf3325-ff33-40b7-9ae4-4f29eaf56c20", + "image_id": 203796, + "image_name": "120932.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 3222.006, + 1606.379, + 1214.627, + 78.71499999999992 + ], + "priority": 20, + "parents": [ + 84806 + ], + "children": [], + "area": 5175762.776273999, + "iscrowd": 0, + "segmentation": [], + "text": "Table 3: Linear Regression Model of:Treatment Group and Cognitive Insight (self-\nreflectiveness) in Relation to Everyday’Functioning at End of Treatment." + }, + { + "id": 84807, + "strid": "23719804-da3c-4675-b488-98d819a45677", + "image_id": 203796, + "image_name": "120932.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3222.113, + 2356.563, + 944.7319999999995, + 118.43199999999979 + ], + "priority": 21, + "parents": [ + 84802 + ], + "children": [], + "area": 7593112.277619, + "iscrowd": 0, + "segmentation": [], + "text": "Note: Full model: R? = 0.112 F(4, 70)= 2.208 P= .077. CBSST,\ncognitive-behavioral social skills training; GFSC, goal-focused\nsupportive contact." + }, + { + "id": 84808, + "strid": "aefc8c65-5277-48d8-b4e9-42de176e9ed1", + "image_id": 203796, + "image_name": "120932.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3221.16, + 2512.541, + 541.9360000000001, + 83.13000000000011 + ], + "priority": 22, + "parents": [ + 84822 + ], + "children": [ + 84809 + ], + "area": 8093296.56756, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 84809, + "strid": "ce6aeabd-52ad-410d-8a6f-e48c03f356dc", + "image_id": 203796, + "image_name": "120932.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3195.634, + 2625.071, + 1475.924, + 470.20600000000013 + ], + "priority": 23, + "parents": [ + 84808 + ], + "children": [], + "area": 8388766.140014, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 90951, + "strid": "cf65ee24-1dff-4f49-8049-825876c32b0a", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 139.73, + 267.52, + 191.56000000000003, + 146.87 + ], + "priority": -1, + "parents": [], + "children": [ + 90917, + 90919, + 90920, + 90921, + 90915, + 90914, + 90916, + 90918 + ], + "area": 37380.569599999995, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 90914, + "strid": "2a6760f9-1e27-4c4c-9e2a-2a2f674263ee", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 68.3, + 84.377, + 3761.017, + 128.702 + ], + "priority": 1, + "parents": [ + 90951 + ], + "children": [], + "area": 5762.9491, + "iscrowd": 0, + "segmentation": [], + "text": "High-throughput characterization of the ovarian cancer HLA peptidome" + }, + { + "id": 90915, + "strid": "13d25573-9e4d-479c-bdfc-5844947f11a3", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 409.42, + 243.379, + 3083.549, + 132.75000000000003 + ], + "priority": 2, + "parents": [ + 90951 + ], + "children": [], + "area": 99644.23018, + "iscrowd": 0, + "segmentation": [], + "text": "Andrea Patterson, Wilfried Bardet, Curtis McMurtry, Saghar Kaabinejadian, Ken Jackson, and William Hildebrand\nDepartment of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA" + }, + { + "id": 90916, + "strid": "7de41695-c6ff-40ef-b69c-e4cd9f61396e", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 806.62, + 486.246, + 392.53100000000006, + 73.81899999999996 + ], + "priority": 3, + "parents": [ + 90951 + ], + "children": [ + 90922, + 90927 + ], + "area": 392215.74851999996, + "iscrowd": 0, + "segmentation": [], + "text": "Background" + }, + { + "id": 90927, + "strid": "5ba4ee05-3ea0-44b5-bd02-2ff228de204f", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 120.716, + 587.101, + 208.7, + 295.39099999999996 + ], + "priority": 4, + "parents": [ + 90916 + ], + "children": [], + "area": 70872.484316, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 90922, + "strid": "b6eb5a46-5470-4b50-819e-01efa997e125", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 368.89, + 594.631, + 1496.4630000000002, + 279.721 + ], + "priority": 5, + "parents": [ + 90916 + ], + "children": [], + "area": 219353.42958999999, + "iscrowd": 0, + "segmentation": [], + "text": "T cells recognize cancer cells via human leukocyte antigen (HLA)/peptide complexes, and class |\nHLA-restricted tumor infiltrating T lymphocytes correspond to favorable prognosis in several cancers,\nincluding ovarian cancer—the most deadly gynecologic disease. The accurate identification of\ntumor-specific HLA/peptide complexes is pivotal to their exploitation as targets in immunotherapies\nsuch as peptide vaccination, transgenic T cell therapy, or TCR-like antibody tumor targeting. Here, a\nhigh-throughput peptide analysis method was used to directly sequence the HLA-A*02:01 peptidome\nof ovarian cancer cells and to identify HLA/peptide complexes for tumor targeting." + }, + { + "id": 90918, + "strid": "cfa3b702-c7f4-43d5-b66c-9f31ac595795", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 860.903, + 951.87, + 280.55500000000006, + 63.98599999999999 + ], + "priority": 6, + "parents": [ + 90951 + ], + "children": [ + 90926 + ], + "area": 819467.73861, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 90926, + "strid": "e6d74e02-857a-4b74-ade2-fcef8f0040fa", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 106.007, + 1053.744, + 1769.163, + 752.28 + ], + "priority": 7, + "parents": [ + 90918 + ], + "children": [], + "area": 111704.240208, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 90919, + "strid": "5487d885-070e-4f6f-b294-ee47ca2d14f3", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 880.318, + 1845.235, + 243.19000000000005, + 60.797000000000025 + ], + "priority": 8, + "parents": [ + 90951 + ], + "children": [ + 90931, + 90929, + 90928, + 90930 + ], + "area": 1624393.5847299998, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 90928, + "strid": "ef119ae5-9f67-4b5b-bcd3-00d0e5d7ebd1", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 157.153, + 1972.979, + 541.826, + 404.807 + ], + "priority": 9, + "parents": [ + 90919 + ], + "children": [ + 90940 + ], + "area": 310059.56878699997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 90940, + "strid": "aecf4e73-cc1c-483a-82b3-b00146925135", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 138.464, + 2390.971, + 616.1670000000001, + 118.66899999999987 + ], + "priority": 10, + "parents": [ + 90928 + ], + "children": [], + "area": 331063.408544, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. Total number of non-redundant\npeptides identified from each cell line at a\n1% false discovery rate (FDR)." + }, + { + "id": 90929, + "strid": "62152027-7250-4e82-a549-62dd69889869", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 804.11, + 1975.59, + 1019.8190000000001, + 414.32600000000025 + ], + "priority": 11, + "parents": [ + 90919 + ], + "children": [ + 90941 + ], + "area": 1588591.6749, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 90941, + "strid": "a1edabef-fbdf-4986-afac-f74d089d3c88", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 837.989, + 2397.735, + 979.4839999999999, + 115.49099999999999 + ], + "priority": 12, + "parents": [ + 90929 + ], + "children": [], + "area": 2009275.5549150002, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2. Peptide length frequencies for all cell lines. 9mers were\nmost frequent as expected, and low-frequency long peptides were\nalso detectable." + }, + { + "id": 90930, + "strid": "a763c4b5-6a34-4572-ba3d-7d96a397a94e", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 152.68, + 2546.506, + 1661.6, + 585.6280000000002 + ], + "priority": 13, + "parents": [ + 90919 + ], + "children": [ + 90950 + ], + "area": 388800.53608, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 90950, + "strid": "17cbbfe0-d3e0-45fb-a32a-6cafaf1c46e6", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 137.381, + 3144.389, + 1660.324, + 118.88599999999997 + ], + "priority": 14, + "parents": [ + 90930 + ], + "children": [], + "area": 431979.305209, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3. Strong HLA-A*02:01 motif of A2780 peptides, representative of all cell lines. The high yield of peptide\nidentifications also highlights other subtle amino acid preferences and tolerance/intolerance at various positions.\nLeft, heat map of amino acid frequencies at each position. Right, primary and secondary anchor positions." + }, + { + "id": 90931, + "strid": "4ecb5f44-9856-4a69-a977-673230197972", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 699.295, + 3299.843, + 1200.958, + 465.46100000000024 + ], + "priority": 15, + "parents": [ + 90919 + ], + "children": [ + 90949 + ], + "area": 2307563.710685, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 90949, + "strid": "44d91e6c-4985-45a0-877e-2cb618a6b79d", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 136.593, + 3299.906, + 559.149, + 401.308 + ], + "priority": 16, + "parents": [ + 90931 + ], + "children": [], + "area": 450744.060258, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 4. Source protein sampling\nbias by A*02:01. Left, Source protein\ncellular locations (all cell lines\ncombined; no difference observed\nbetween cancer and non-cancer)\ncompared to unbiased protein\nlocation frequencies. Right, source\nprotein location frequencies showing\nSEM of individual cell lines, as\ncompared to all proteins." + }, + { + "id": 90917, + "strid": "750fde93-fada-45ee-9f80-71adc4ea3506", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2011.18, + 482.243, + 1746.809, + 75.52400000000006 + ], + "priority": 17, + "parents": [ + 90951 + ], + "children": [ + 90934, + 90938, + 90935, + 90925, + 90932, + 90939, + 90933, + 90936, + 90937 + ], + "area": 969877.4767400001, + "iscrowd": 0, + "segmentation": [], + "text": "Two classes of peptide candidates for immunotherapy:" + }, + { + "id": 90938, + "strid": "2ba653fe-e77d-4033-82a0-1879a52cb460", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2264.075, + 641.694, + 1264.33, + 74.46100000000001 + ], + "priority": 18, + "parents": [ + 90917 + ], + "children": [], + "area": 1452843.3430499998, + "iscrowd": 0, + "segmentation": [], + "text": "Class 1: Consistent and cancer-specific" + }, + { + "id": 90935, + "strid": "9f5f1354-e299-4447-8159-9ffdc3cb03d9", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1960.454, + 778.041, + 855.3659999999998, + 372.29700000000014 + ], + "priority": 19, + "parents": [ + 90917 + ], + "children": [ + 90944 + ], + "area": 1525313.590614, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 90944, + "strid": "18d2555a-368f-48ec-8b8a-7521cf63d27d", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1996.292, + 1168.155, + 801.0239999999999, + 157.87400000000002 + ], + "priority": 20, + "parents": [ + 90935 + ], + "children": [], + "area": 2331978.48126, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 5. Number of shared and unique non-\nredundant peptide identifications. Those consistent in\nthe cancerous and absent in the non-cancerous are\nthe candidate cancer targets." + }, + { + "id": 90936, + "strid": "561e543b-a693-4630-9a64-3809aea3db71", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2871.731, + 842.474, + 916.558, + 427.505 + ], + "priority": 21, + "parents": [ + 90917 + ], + "children": [ + 90943 + ], + "area": 2419358.7024940006, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 90943, + "strid": "350dd0bd-a068-4e2b-a3f4-00aa571b890a", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2870.171, + 753.257, + 898.2310000000002, + 79.56600000000003 + ], + "priority": 22, + "parents": [ + 90936 + ], + "children": [], + "area": 2161976.3969469997, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1. Source proteins of candidate peptides§ with highest\noverall abundance among ovarian cancer lines" + }, + { + "id": 90939, + "strid": "0e1f2a14-f854-4c6c-9db7-8b1d26dcadf0", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2120.396, + 1400.758, + 1570.5530000000003, + 75.33799999999997 + ], + "priority": 23, + "parents": [ + 90917 + ], + "children": [], + "area": 2970161.6601680005, + "iscrowd": 0, + "segmentation": [], + "text": "Class 2: Tumor associated antigen (TAA) focused" + }, + { + "id": 90937, + "strid": "12a349f2-d895-465f-beaf-fa90a92e8ab3", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2008.502, + 1600.113, + 846.0700000000002, + 618.358 + ], + "priority": 24, + "parents": [ + 90917 + ], + "children": [ + 90945 + ], + "area": 3213830.160726, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 90945, + "strid": "e85966ca-b646-4b32-994b-3f549fdce9dc", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2017.942, + 1506.39, + 786.0439999999999, + 79.57500000000005 + ], + "priority": 25, + "parents": [ + 90937 + ], + "children": [], + "area": 3039807.6493800003, + "iscrowd": 0, + "segmentation": [], + "text": "Table 2. List of several recognized TAA from which\npeptides were sequenced in the ovarian cancer lines" + }, + { + "id": 90934, + "strid": "e273018e-d733-4c16-bde9-18240c559ac0", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2908.664, + 1524.03, + 866.8939999999998, + 450.55899999999997 + ], + "priority": 26, + "parents": [ + 90917 + ], + "children": [ + 90946 + ], + "area": 4432891.19592, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 90946, + "strid": "30192042-8b75-41ed-aaad-404dcccdd9e8", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2905.025, + 1984.763, + 912.7840000000001, + 241.16699999999992 + ], + "priority": 27, + "parents": [ + 90934 + ], + "children": [], + "area": 5765786.134075, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 6. HER2 representation showing the approximate\nlocations of 46 peptides identified at a 1% FDR from the\nHER2\"i cell line SKOV3. This is the first identification of HER2\npeptides directly eluted from the HLA of cancer cells. Those\npeptides previously predicted and shown immunogenic in the\nliterature are represented in blue, with novel peptides in red." + }, + { + "id": 90932, + "strid": "872ee6d0-eae5-4512-87db-2ca25c8216c1", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2380.106, + 2255.822, + 915.904, + 354.1999999999998 + ], + "priority": 28, + "parents": [ + 90917 + ], + "children": [ + 90942 + ], + "area": 5369095.477132001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 90942, + "strid": "1ef7943a-4174-4c9b-a4dd-ea814051ed36", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2020.931, + 2262.936, + 341.24900000000025, + 321.36299999999983 + ], + "priority": 29, + "parents": [ + 90932 + ], + "children": [], + "area": 4573237.513416001, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 8. SKOV3\nsource proteins by\npeptide number. At\n>40 peptides identified\n(beyond the figure),\nHER2 is one of the\nmost highly sampled\nproteins in SKOV3." + }, + { + "id": 90933, + "strid": "ea5cefbb-4d57-4c29-bc9c-23ade083db10", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1973.033, + 2657.745, + 721.1219999999998, + 299.692 + ], + "priority": 30, + "parents": [ + 90917 + ], + "children": [ + 90947 + ], + "area": 5243818.590585, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 90947, + "strid": "86e6d031-cb12-46bf-b094-7bddcd6fd3cc", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2004.227, + 2959.28, + 683.338, + 159.11400000000003 + ], + "priority": 31, + "parents": [ + 90933 + ], + "children": [], + "area": 5931068.876560001, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 7. HER2 surface staining. SKOV3 is a\nknown HER2\" cell line, and the three other\nlines are HER2'. Left, Overlaid histograms.\nRight, MFI Ratio (MFIR) over isotype controls." + }, + { + "id": 90925, + "strid": "f3820d0d-876c-4797-ad94-c2673d8b676b", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2755.68, + 2289.634, + 1088.112, + 763.8310000000001 + ], + "priority": 32, + "parents": [ + 90917 + ], + "children": [ + 90948 + ], + "area": 6309498.621119999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 90948, + "strid": "467b2bf3-a1fa-46fc-b379-0e4586a8e32f", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2739.445, + 3054.728, + 1083.4649999999997, + 78.34700000000021 + ], + "priority": 33, + "parents": [ + 90925 + ], + "children": [], + "area": 8368259.3459600005, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 9. Relative abundance of the HER2 peptides detected in SKOV3,\nbased on observed MS extracted ion chromatogram (XIC) peak areas." + }, + { + "id": 90920, + "strid": "e1a378da-44bd-4312-a27b-e09afd5e37a9", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2737.43, + 3173.788, + 311.5169999999998, + 74.7199999999998 + ], + "priority": 34, + "parents": [ + 90951 + ], + "children": [ + 90924 + ], + "area": 8688022.48484, + "iscrowd": 0, + "segmentation": [], + "text": "Summary" + }, + { + "id": 90924, + "strid": "694bfd96-acbb-4dc5-a0d2-360c76f32a44", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2014.859, + 3268.927, + 1724.607, + 240.23300000000017 + ], + "priority": 35, + "parents": [ + 90920 + ], + "children": [], + "area": 6586426.986293, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 90921, + "strid": "a2eec632-5290-4604-9901-3b20ecc12520", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2756.658, + 3570.412, + 271.4670000000001, + 77.4670000000001 + ], + "priority": 36, + "parents": [ + 90951 + ], + "children": [ + 90923 + ], + "area": 9842404.803095998, + "iscrowd": 0, + "segmentation": [], + "text": "Funding" + }, + { + "id": 90923, + "strid": "84c70002-6273-450b-8a1f-38353b8229d0", + "image_id": 204027, + "image_name": "121344.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2029.015, + 3669.31, + 1645.128, + 80.41199999999981 + ], + "priority": 37, + "parents": [ + 90921 + ], + "children": [], + "area": 7445085.02965, + "iscrowd": 0, + "segmentation": [], + "text": "This work was partially funded by the NRSA NIAID Ruth L. Kirschstein Training Grant T32AI007633, “Molecular\nBasis of Immunity”." + }, + { + "id": 176121, + "strid": "d19c39c6-2213-4149-a471-5db13d862e06", + "image_id": 207374, + "image_name": "7495.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 14.61, + 122.61, + 54.459999999999994, + 204.20999999999998 + ], + "priority": -1, + "parents": [], + "children": [ + 176107, + 176110, + 176119, + 176106, + 176118, + 176105, + 176120, + 176115, + 176114, + 176104, + 176116, + 176112, + 176111, + 176109, + 176113, + 176117, + 176108 + ], + "area": 1791.3320999999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 176104, + "strid": "ac088385-7e5d-419c-aa9e-07abac8ab5e8", + "image_id": 207374, + "image_name": "7495.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 46.656, + 10.083, + 3282.268, + 104.574 + ], + "priority": 1, + "parents": [ + 176121 + ], + "children": [], + "area": 470.432448, + "iscrowd": 0, + "segmentation": [], + "text": "EFFECTIVENESS OF ENAMELOPLASTY IN TREATING DENTAL FLUOROSIS" + }, + { + "id": 176120, + "strid": "b25618a6-b928-49a2-9db0-2d77268f474e", + "image_id": 207374, + "image_name": "7495.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 3141.52, + 2602.702, + 812.1880000000001, + 180.48599999999988 + ], + "priority": 2, + "parents": [ + 176121 + ], + "children": [], + "area": 8176440.38704, + "iscrowd": 0, + "segmentation": [], + "text": "Pooja Luniya (Intern)\n\nDr. Rahul Kathariya (Guide\n—___" + }, + { + "id": 176119, + "strid": "ed3a81b3-759e-4bce-bfdb-aceb3fbe12fa", + "image_id": 207374, + "image_name": "7495.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3341.583, + 0.0, + 658.3989999999999, + 174.33700000000002 + ], + "priority": 3, + "parents": [ + 176121 + ], + "children": [], + "area": 0.0, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 176105, + "strid": "d1849a5f-ae8b-4f42-9e88-d314c6159aa2", + "image_id": 207374, + "image_name": "7495.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 76.869, + 191.077, + 3847.938, + 189.687 + ], + "priority": 4, + "parents": [ + 176121 + ], + "children": [], + "area": 14687.897913, + "iscrowd": 0, + "segmentation": [], + "text": "Dental fluorosis is a serious irreversible aesthetic condition affecting over 62 million people in India. It disturbs\ntheir interaction and relationships leading to embarrassment, exclusions, loneliness and long-term depressions." + }, + { + "id": 176106, + "strid": "99349faf-e9d4-4cb6-a859-c5c9f56cf380", + "image_id": 207374, + "image_name": "7495.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 5.725, + 391.566, + 752.037, + 206.17400000000004 + ], + "priority": 5, + "parents": [ + 176121 + ], + "children": [], + "area": 2241.7153499999995, + "iscrowd": 0, + "segmentation": [], + "text": "AIM : To evaluate the\neffectiveness of enameloplasty\nin treating dental fluorosis." + }, + { + "id": 176107, + "strid": "299347c8-db8b-4eb7-9b93-c64b14ccf104", + "image_id": 207374, + "image_name": "7495.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 13.707, + 624.301, + 790.454, + 316.21799999999996 + ], + "priority": 6, + "parents": [ + 176121 + ], + "children": [], + "area": 8557.293807000002, + "iscrowd": 0, + "segmentation": [], + "text": "OBJECTIVE :To verify the\neffectiveness of enameloplasty\nby Visual Comparison, Visual\n\nAnalogue Scale (VAS), Patient’s\nsatisfaction scale." + }, + { + "id": 176108, + "strid": "b833fef3-5807-4c9c-ad11-c9f8955b8fbf", + "image_id": 207374, + "image_name": "7495.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 36.714, + 983.459, + 742.2650000000001, + 399.4309999999999 + ], + "priority": 7, + "parents": [ + 176121 + ], + "children": [], + "area": 36106.713725999994, + "iscrowd": 0, + "segmentation": [], + "text": "MATERIALS $ METHOD:\nThe novel technique of\nenameloplasty in 5 moderate\nand severely affected cases as\nper Dean’s Fluorosis Index\n(modified criteria)" + }, + { + "id": 176109, + "strid": "44c9d312-4bf0-4424-a3a9-2333b9ae2814", + "image_id": 207374, + "image_name": "7495.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 18.253, + 1450.295, + 782.298, + 267.62799999999993 + ], + "priority": 8, + "parents": [ + 176121 + ], + "children": [], + "area": 26472.234635, + "iscrowd": 0, + "segmentation": [], + "text": "Removal of 0.1-0.3mm of\naffected enamel ( using\nfinishing and polishing tapered\nfissure burs)" + }, + { + "id": 176110, + "strid": "d0fadfbe-4611-454c-80e3-52873ab38a96", + "image_id": 207374, + "image_name": "7495.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 120.251, + 1780.009, + 572.751, + 138.93499999999995 + ], + "priority": 9, + "parents": [ + 176121 + ], + "children": [], + "area": 214047.86225900002, + "iscrowd": 0, + "segmentation": [], + "text": "Polishing (brush and\nhypersensitivity paste)" + }, + { + "id": 176111, + "strid": "2b12b319-b869-460c-81ea-384cdabab39e", + "image_id": 207374, + "image_name": "7495.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 22.336, + 1955.589, + 734.368, + 327.50199999999995 + ], + "priority": 10, + "parents": [ + 176121 + ], + "children": [], + "area": 43680.035904, + "iscrowd": 0, + "segmentation": [], + "text": "Visual comparison - (shade\nimproved by 7-10 shades)\nVisual analogue scale -1( no-\nmild pain)\n\nPatient’s satisfaction scale - 8" + }, + { + "id": 176114, + "strid": "d13909be-75d1-4806-a98c-3ce45209824c", + "image_id": 207374, + "image_name": "7495.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 5.832, + 2304.1, + 822.518, + 203.19999999999982 + ], + "priority": 11, + "parents": [ + 176121 + ], + "children": [], + "area": 13437.511199999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 176115, + "strid": "2d77f71c-fe19-415e-a1d3-f085f900d76e", + "image_id": 207374, + "image_name": "7495.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 819.053, + 372.423, + 2338.969, + 2427.5600000000004 + ], + "priority": 12, + "parents": [ + 176121 + ], + "children": [], + "area": 305034.175419, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 176116, + "strid": "71fd51ba-0d4d-402d-bb45-0e569a0e19a9", + "image_id": 207374, + "image_name": "7495.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3162.934, + 438.768, + 375.8299999999999, + 198.07300000000004 + ], + "priority": 13, + "parents": [ + 176121 + ], + "children": [], + "area": 1387794.225312, + "iscrowd": 0, + "segmentation": [], + "text": "Is your smile\ngiving the right\nfirst impression?" + }, + { + "id": 176117, + "strid": "57866795-47a3-4d90-8dc2-90dfc90a0183", + "image_id": 207374, + "image_name": "7495.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3642.033, + 403.217, + 282.71900000000005, + 281.02599999999995 + ], + "priority": 14, + "parents": [ + 176121 + ], + "children": [], + "area": 1468529.620161, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 176112, + "strid": "7e75b170-0a32-49b9-bb01-af8d7ce277d7", + "image_id": 207374, + "image_name": "7495.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3196.229, + 706.161, + 768.3519999999999, + 466.58000000000004 + ], + "priority": 15, + "parents": [ + 176121 + ], + "children": [], + "area": 2257052.2668689997, + "iscrowd": 0, + "segmentation": [], + "text": "ESULT: This technique is so\neffective that it reverses Dean’\nIndex for Dental Fluorosis\n(modified criteria) of 4/3 to 0.5\n(Questionable) or 0 (Normal)\nwith bearable sensitivity and\nexcellent patient satisfaction." + }, + { + "id": 176113, + "strid": "989b0e5c-3da5-4466-b9cb-714ddc0befd2", + "image_id": 207374, + "image_name": "7495.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3290.617, + 1212.845, + 582.6440000000002, + 466.779 + ], + "priority": 16, + "parents": [ + 176121 + ], + "children": [], + "area": 3991008.375365, + "iscrowd": 0, + "segmentation": [], + "text": "CONCLUSION:\nSimple & Easy Tech\nReliable\nAffordable\nPermanent Cure\nEffective treatment\nRegains self confidence" + }, + { + "id": 176118, + "strid": "68a6dfb5-a9e3-4cd3-84bf-dbec07fd3227", + "image_id": 207374, + "image_name": "7495.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3257.06, + 1756.955, + 671.797, + 824.3229999999999 + ], + "priority": 17, + "parents": [ + 176121 + ], + "children": [], + "area": 5722507.852299999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 121971, + "strid": "9ebd8d0d-cda1-4276-bbbc-8c8dfd591d22", + "image_id": 205247, + "image_name": "14508.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 607.44, + 65.43, + 220.08999999999992, + 249.06 + ], + "priority": -1, + "parents": [], + "children": [ + 121943, + 121950, + 121954, + 121948, + 121964, + 121945, + 121951, + 121949, + 121953, + 121965, + 121946, + 121952, + 121947, + 121966, + 121944 + ], + "area": 39744.79920000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 121943, + "strid": "aea13a1d-eb78-4e96-a815-220632800720", + "image_id": 205247, + "image_name": "14508.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 894.0, + 139.629, + 3286.974, + 291.673 + ], + "priority": 1, + "parents": [ + 121971 + ], + "children": [], + "area": 124828.32599999999, + "iscrowd": 0, + "segmentation": [], + "text": "Characterization of Childhood Obesity in Urban and\nRural Michigan" + }, + { + "id": 121944, + "strid": "b43631d2-74fe-455e-921f-e9d25a9af9b7", + "image_id": 205247, + "image_name": "14508.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 539.324, + 489.939, + 3715.5009999999997, + 251.86099999999993 + ], + "priority": 2, + "parents": [ + 121971 + ], + "children": [], + "area": 264235.86123599997, + "iscrowd": 0, + "segmentation": [], + "text": "Jessica Olson’ BA, Heather Aldrich! PhD, Tiffany Callahan? BA, Bonnie Gance-Cleveland! PhD, RNC, PNP, FAAN\n\nUniversity of Colorado Anschutz Medical Campus, ‘College of Nursing, @School of Public Health, Aurora, CO\nContact: Jessica.Olson@UCDenver.edu" + }, + { + "id": 121945, + "strid": "b6ac5140-7102-4bac-9a55-2bcebf9e4eae", + "image_id": 205247, + "image_name": "14508.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 461.814, + 967.45, + 280.77000000000004, + 56.309999999999945 + ], + "priority": 3, + "parents": [ + 121971 + ], + "children": [ + 121967 + ], + "area": 446781.95430000004, + "iscrowd": 0, + "segmentation": [], + "text": "Background" + }, + { + "id": 121967, + "strid": "4408184f-57d9-4243-84e4-aa890d3f386f", + "image_id": 205247, + "image_name": "14508.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 83.345, + 1054.819, + 1041.793, + 1161.092 + ], + "priority": 4, + "parents": [ + 121945 + ], + "children": [], + "area": 87913.889555, + "iscrowd": 0, + "segmentation": [], + "text": "Pediatric overweight and obesity are defined by a child’s percentile on\nthe Centers for Disease Control and Prevention Body Mass Index\n(BMI)-for-age growth chart. Overweight is defined as 2 85\" percentile\nbut < 95\" percentile. Obese youth are = 95\" percentile. In the United\nStates 31.8% of youth aged 2 through 19 were overweight or obese\nin 2011-2012.' In Michigan 33% of youth aged 10-17 were overweight\nor obese in 2013.2 This rate continues to rise. Childhood obesity is a\nwell-documented risk factor for chronic physical and mental illness,\nadult obesity, and early mortality.\n\nResearchers have attempted to characterize childhood obesity and its\nrisk factors. Guidelines to help clinicians address childhood obesity\nemphasize evidence-based interventions. Children living in rural\nareas have higher rates of obesity/overweight than children living in\nurban areas.? Increased physical activity is associated with\ndecreased rates of obesity in children.* Guidelines recommend 60\nminutes of moderate to vigorous physical activity daily.5®7 Increased\nscreen time is associated with increased rates of obesity in children.*\nGuidelines recommend less than 2 hours daily “screen time” for\nchildren.55” Daily breakfast consumption is associated with\ndecreased rates of obesity in children.* Guidelines recommend that\nchildren eat breakfast daily.5 5”\n\nDue to the high prevalence and various associated negative health\noutcomes, the issue of childhood obesity has entered the national\nspotlight in recent years. Healthy People 2020 includes the following\nobjective: “Promote health and reduce chronic disease risk through\nthe consumption of healthful diets and achievement and maintenance\nof healthy body weights.”" + }, + { + "id": 121948, + "strid": "09f1de67-eedd-4e8c-8756-f2f0bd509117", + "image_id": 205247, + "image_name": "14508.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 501.874, + 2335.01, + 204.15499999999997, + 55.14499999999998 + ], + "priority": 5, + "parents": [ + 121971 + ], + "children": [ + 121968 + ], + "area": 1171880.8087400002, + "iscrowd": 0, + "segmentation": [], + "text": "Purpose" + }, + { + "id": 121968, + "strid": "2b4bd62c-8ade-462d-a0ab-ddc7f6db91a8", + "image_id": 205247, + "image_name": "14508.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 83.458, + 2447.946, + 1040.528, + 118.16699999999992 + ], + "priority": 6, + "parents": [ + 121948 + ], + "children": [], + "area": 204300.677268, + "iscrowd": 0, + "segmentation": [], + "text": "To characterize childhood obesity levels and risk behaviors in two\nschool-based health centers (SBHCs) in Michigan, one urban and\none rural." + }, + { + "id": 121949, + "strid": "eb4559ea-0bca-4411-b4ce-924fa07c19e6", + "image_id": 205247, + "image_name": "14508.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 371.992, + 2628.567, + 460.253, + 49.48900000000003 + ], + "priority": 7, + "parents": [ + 121971 + ], + "children": [ + 121969 + ], + "area": 977805.8954640001, + "iscrowd": 0, + "segmentation": [], + "text": "Research Questions" + }, + { + "id": 121969, + "strid": "8676841e-7681-4b04-a740-67f690eb98d4", + "image_id": 205247, + "image_name": "14508.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 85.257, + 2724.17, + 1037.635, + 320.9250000000002 + ], + "priority": 8, + "parents": [ + 121949 + ], + "children": [], + "area": 232254.56169000003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 121950, + "strid": "5dcadd38-7470-4917-bea2-8430c18deff4", + "image_id": 205247, + "image_name": "14508.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 339.995, + 3172.365, + 525.818, + 46.25199999999995 + ], + "priority": 9, + "parents": [ + 121971 + ], + "children": [ + 121970 + ], + "area": 1078588.2381749998, + "iscrowd": 0, + "segmentation": [], + "text": "Theoretical Framework" + }, + { + "id": 121970, + "strid": "7a46fe00-80e2-47e0-80e9-2c19b1e7d220", + "image_id": 205247, + "image_name": "14508.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 85.611, + 3281.42, + 1038.567, + 162.31100000000015 + ], + "priority": 10, + "parents": [ + 121950 + ], + "children": [], + "area": 280925.64762, + "iscrowd": 0, + "segmentation": [], + "text": "Energy Balance Model: Energy balance is an established model for\nunderstanding obesity which states that energy expenditure\nsubtracted from energy intake gives the change in body stores of\nenergy in the form of fat, glycogen, and protein.®" + }, + { + "id": 121947, + "strid": "c60225eb-8c08-45ed-9c4e-a1eba6767a54", + "image_id": 205247, + "image_name": "14508.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1656.743, + 970.598, + 195.45800000000008, + 43.75300000000004 + ], + "priority": 11, + "parents": [ + 121971 + ], + "children": [ + 121960, + 121961, + 121962 + ], + "area": 1608031.4423139999, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 121960, + "strid": "8ea9d40e-389b-4533-b2e0-51849bffeec8", + "image_id": 205247, + "image_name": "14508.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1232.93, + 1019.911, + 1042.262, + 245.7779999999999 + ], + "priority": 12, + "parents": [ + 121947 + ], + "children": [], + "area": 1257478.86923, + "iscrowd": 0, + "segmentation": [], + "text": "Setting:\n\nMichigan was chosen due to high and increasing rates of pediatric\noverweight and obesity. Two SBHCs were selected, one urban and\none rural. SBHCs are located on school campuses to provide\nhealthcare to students and their families. They are often used by\nunderserved populations." + }, + { + "id": 121961, + "strid": "0452a641-a7a7-401d-ba4e-1b1ec341dc45", + "image_id": 205247, + "image_name": "14508.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1235.853, + 1300.9, + 1043.7579999999998, + 201.2739999999999 + ], + "priority": 13, + "parents": [ + 121947 + ], + "children": [], + "area": 1607721.1677, + "iscrowd": 0, + "segmentation": [], + "text": "Data Collection:\nHeartSmartKids™ is an English-Spanish bilingual electronic decision-\nsupport technology designed to help providers identify, assess, and\ncounsel on the weight status of children.? Children seen in two\nSBHCs in Michigan completed the HeartSmartKids™ lifestyle survey." + }, + { + "id": 121962, + "strid": "aee741a2-5288-46d4-a841-fb09bc778bee", + "image_id": 205247, + "image_name": "14508.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1236.848, + 1541.416, + 1039.5640000000003, + 195.731 + ], + "priority": 14, + "parents": [ + 121947 + ], + "children": [], + "area": 1906497.296768, + "iscrowd": 0, + "segmentation": [], + "text": "Statistical Analysis:\n\nDifferences by urban/rural status were evaluated with independent\nsamples t-tests or Pearson’s chi-square tests. A multiple logistic\nregression model was used to examine the research questions of\ninterest." + }, + { + "id": 121964, + "strid": "34c33e6e-0301-4dc0-b432-ed545b33a444", + "image_id": 205247, + "image_name": "14508.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1217.092, + 1832.593, + 1077.301, + 1109.066 + ], + "priority": 15, + "parents": [ + 121971 + ], + "children": [ + 121963 + ], + "area": 2230434.279556, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 121963, + "strid": "6361b760-bb66-4766-9092-3b151044d9b6", + "image_id": 205247, + "image_name": "14508.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1233.81, + 2951.064, + 1039.917, + 82.46500000000015 + ], + "priority": 16, + "parents": [ + 121964 + ], + "children": [], + "area": 3641052.2738399995, + "iscrowd": 0, + "segmentation": [], + "text": "Population density map of Michigan with stars to mark the two SBHCs\nin this project." + }, + { + "id": 121946, + "strid": "c5938696-f5af-4b01-87c5-1df4e1ffcf49", + "image_id": 205247, + "image_name": "14508.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2883.14, + 971.614, + 168.29599999999982, + 41.735000000000014 + ], + "priority": 17, + "parents": [ + 121971 + ], + "children": [ + 121959 + ], + "area": 2801299.18796, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 121959, + "strid": "336cd060-628d-49ce-a509-61b1dfd1e8a9", + "image_id": 205247, + "image_name": "14508.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2382.715, + 1061.694, + 1172.246, + 404.548 + ], + "priority": 18, + "parents": [ + 121946 + ], + "children": [], + "area": 2529714.2192100002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 121966, + "strid": "b8fae897-d50d-4705-b180-00810ffc3da3", + "image_id": 205247, + "image_name": "14508.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2359.134, + 1523.718, + 1216.8670000000002, + 667.1829999999998 + ], + "priority": 19, + "parents": [ + 121971 + ], + "children": [], + "area": 3594654.940212, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 121965, + "strid": "d5dd19c4-3e80-40de-b61e-31bc7f320367", + "image_id": 205247, + "image_name": "14508.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2358.437, + 2225.361, + 1218.4899999999998, + 952.1210000000001 + ], + "priority": 20, + "parents": [ + 121971 + ], + "children": [], + "area": 5248373.720756999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 121954, + "strid": "4b20e092-6869-41ba-8e40-cd4cdf98e07b", + "image_id": 205247, + "image_name": "14508.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4056.574, + 971.706, + 249.87800000000016, + 43.572 + ], + "priority": 21, + "parents": [ + 121971 + ], + "children": [ + 121958 + ], + "area": 3941797.295244, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion" + }, + { + "id": 121958, + "strid": "692c84b2-c38b-43ab-8474-738e28a9d576", + "image_id": 205247, + "image_name": "14508.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3651.221, + 1077.64, + 1063.3089999999997, + 805.137 + ], + "priority": 22, + "parents": [ + 121954 + ], + "children": [], + "area": 3934701.7984400005, + "iscrowd": 0, + "segmentation": [], + "text": "The rate of obesity/overweight was much higher in this population\n(58.1%) than the national average (31.8%) and the Michigan average\n(33%). The population studied is of low socioeconomic status\ncompared to the national average and Michigan, and poverty has been\ndemonstrated to be a significant risk factor for childhood obesity. 1°\n\nThe urban group had a_ significantly higher number of\nobese/overweight children at 67.2% than the rural group at 46.8%. The\nurban group was older, got fewer hours of sleep, ate breakfast less\nfrequently, ate out more frequently, ate more junk snacks, and drank\nmore sweet beverages.\n\nPredictors of obesity included amount of nocturnal sleep and frequency\nof breakfast consumption. These hormonal and metabolic factors are\nnot emphasized in the energy balance model.\n\nLimitations of this study include small sample size, non-random sample\nselection, lack of race/ethnicity data, and self-reported health habits.\nStrengths include measured height and weight and use of technology\nto calculate BMI percentile." + }, + { + "id": 121953, + "strid": "47887b9d-00fd-4fc9-bd36-2e7e71098989", + "image_id": 205247, + "image_name": "14508.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3905.503, + 1999.678, + 553.8520000000003, + 58.15899999999988 + ], + "priority": 23, + "parents": [ + 121971 + ], + "children": [ + 121957 + ], + "area": 7809748.428034001, + "iscrowd": 0, + "segmentation": [], + "text": "Implications for Practice" + }, + { + "id": 121957, + "strid": "def67890-d93b-43d2-8afc-37bfd058bc58", + "image_id": 205247, + "image_name": "14508.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3654.368, + 2092.823, + 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+ "image_name": "120279.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 988.191, + 140.757, + 1332.7030000000002, + 126.75900000000001 + ], + "priority": 2, + "parents": [ + 75967 + ], + "children": [], + "area": 139094.800587, + "iscrowd": 0, + "segmentation": [], + "text": "Rudolph Pienaar'””, Nicolas Rannou\"’, Daniel Haehn’”, P Ellen Grant'*”\n‘Fetal-Neonatal Neuroimaging and Development Science Center, Childrens Hospital Boston\n2A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital\n3Harvard Medical School" + }, + { + "id": 75953, + "strid": "9d1edcdb-7425-49ab-930d-7c2d44b3a1f8", + "image_id": 203461, + "image_name": "120279.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 942.323, + 294.369, + 1465.6620000000003, + 91.56799999999998 + ], + "priority": 3, + "parents": [ + 75967 + ], + "children": [], + "area": 277390.67918700003, + "iscrowd": 0, + "segmentation": [], + "text": "Children's Research Integration System" + }, + { + "id": 75941, + "strid": "9f86903d-18f1-4967-9623-f974b2d597e0", + "image_id": 203461, + "image_name": "120279.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 77.683, + 472.272, + 509.279, + 58.09300000000002 + ], + "priority": 4, + "parents": [ + 75967 + ], + "children": [ + 75954 + ], + "area": 36687.505776000005, + "iscrowd": 0, + "segmentation": [], + "text": "introductton" + }, + { + "id": 75954, + "strid": "500174b1-d2b8-4ed8-bf83-392326e21916", + "image_id": 203461, + "image_name": "120279.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 77.464, + 543.011, + 552.979, + 954.2280000000001 + ], + "priority": 5, + "parents": [ + 75941 + ], + "children": [], + "area": 42063.804103999995, + "iscrowd": 0, + "segmentation": [], + "text": "Children's Research /ntegration System, ChRIS ,\ndeveloped at Boston Children's Hospital, is a\nnovel web-based. data storage and data\nprocessing workflow*manager that provides strict\ndata security. while also facilitating secure,\nrealtime interactive collaboration over the\nInternet and internal Intranets. It was developed\nfrom,éarlier protoypes demonstrating the utility of\nusingthe browser as neuro-imaging analysis\nplatform, [1,2]. Although ChRIS can manage any\ndatatype, it is uniquely suited to medical image\ndata, providing the ability to seamlessly collect\ndata from typical sources found in hospitals\n(such as Picture Archive and Communications\nSystems, PACS), import from CDs/DVDs, users\ndesktops, etc. ChR/S not only manages data\ncollection and organization, but it also provides a\nlarge (and expanding) library of pipelines to\nanalyze imported data. This library is easily\nextensible via a simple plugin mechanism, and\nChRIS also provides the ability to directly interact\nwith compute clusters for data analysis,\nMoreover, a wide variety of 2D, 3D, and 4D\nmedical image data formats are natively\nsupported and can be directly visualized ‘and\nmanipulated within the browser.\n\nUsing a modern Web 2.0 inspiréd design, the\nsystem focuses on simplicity -=both in ease of\nuse and in accessibility“ End users will\nimmediately recognize a/facebook/twitter/gmail\ninspired interface, with a°central news-type “feed”\ncontaining a persistent\\record of activity in the\nsystem, and plugins that can process “feeds”." + }, + { + "id": 75956, + "strid": "6842144b-1fc8-48f0-ae6b-beda51c0c0c0", + "image_id": 203461, + "image_name": "120279.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 694.502, + 431.333, + 1990.1950000000002, + 143.61099999999993 + ], + "priority": 6, + "parents": [ + 75967 + ], + "children": [], + "area": 299561.631166, + "iscrowd": 0, + "segmentation": [], + "text": "Internally, ChRIS associates data to a set of bundled plugins; and users simply select a data set and drag into a chosen plugin/ As shown in the Figure below, ChRIS logically\nhouses a set of pipelines (the radial structures). Theinner ring is data housed internally in ChRIS itself, while the middle ring denotes’ compute resources such as external HPC\nclusters. Results from the pipelines (outer ring) are\"again managed by ChRI/S and can be shared with other system users. Thifd party pipelines bundled with ChRIS include: 3D\nSlicer applications, FSL, FreeSurfer, and the Diffusion Toolkit. Internal pipelines include a connectivity analysis stream called Fyborg, as well as various plugins to connect to PACS\n\nsources, internal searching,messaging, note/feed updates, etc." + }, + { + "id": 75966, + "strid": "febdd830-818f-4660-ad7b-e08b0e0e13d8", + "image_id": 203461, + "image_name": "120279.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 772.424, + 576.221, + 1803.4189999999999, + 1380.84 + ], + "priority": 7, + "parents": [ + 75967 + ], + "children": [], + "area": 445086.929704, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 75955, + "strid": "05aee5ad-6629-417c-81bb-f07d7801780e", + "image_id": 203461, + "image_name": "120279.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 697.069, + 1465.038, + 499.8399999999999, + 483.30899999999997 + ], + "priority": 8, + "parents": [ + 75967 + ], + "children": [], + "area": 1021232.5736219999, + "iscrowd": 0, + "segmentation": [], + "text": "Plugins are the mechanism by whichsusers\ncreate feeds, and plugins are available for\nimporting data, performing various analytical\nprocessing on data, and also\\providing\ndetailed visualization of data and results --\nall within the single-context/approach of the\nChRIS user interface. Actual processing of\ndata is not usually performed by ChRIS, but\nby bundled applications ‘that are connected\nto the feeds throughva plugin mechanism.\nChRIS also provides the ability to natively\nintegrate to High Performance Computing\n(HPC) resources, allowing users to process\ndata on powerful clusters without needing to\nmanage data and results or worry about the\ntransfer and management of data between\nlocal computers and the remote HPC." + }, + { + "id": 75959, + "strid": "def36aa6-465a-45e5-91bb-bdab890ba3f9", + "image_id": 203461, + "image_name": "120279.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1807.729, + 1595.51, + 55.42900000000009, + 228.78600000000006 + ], + "priority": 9, + "parents": [ + 75967 + ], + "children": [], + "area": 2884249.69679, + "iscrowd": 0, + "segmentation": [], + "text": "spoof" + }, + { + "id": 75944, + "strid": "56972ac4-bbd1-459d-ba08-0561633b4c54", + "image_id": 203461, + "image_name": "120279.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2809.625, + 448.078, + 301.23900000000003, + 71.36400000000003 + ], + "priority": 10, + "parents": [ + 75967 + ], + "children": [ + 75957 + ], + "area": 1258931.15075, + "iscrowd": 0, + "segmentation": [], + "text": "plugans" + }, + { + "id": 75957, + "strid": "b96fa1c3-b2ff-485c-aefe-b533ca622b8e", + "image_id": 203461, + "image_name": "120279.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2578.721, + 601.323, + 650.9810000000002, + 843.966 + ], + "priority": 11, + "parents": [ + 75944 + ], + "children": [], + "area": 1550644.247883, + "iscrowd": 0, + "segmentation": [], + "text": "In this example case on left we show the UI for the\nbundled \"Tractography\" plugin. When DTI MR data is\ndropped into the, ‘dti Jinput' box, the plugin calls an\nunderlying diffusion, toolkit engine which can process this\ndata, solvingforso-called \"tracts\" that show the solutions\nto water diffusion equations. These tracts are believed to\napproximate the pattern of white matter \"wires\" within the\nbrain and’can hold important clinical indicators.\n\nImagine that we have “feed” containing DTI data. This\nfeed could have been collected from querying the hospital\nPACS, from inserting a DVD, or a network filesystem\naccess. With the “files” widget open in the feed, the\nappropriate DTI data can be dragged over “Drag and drop\nhere” input box in the plugin.\n\nOn hitting the \"Start job\" button at the bottom of the plugin,\nthe tractography reconstruction is scheduled out on the\nconnected back end cluster, and the job is started. At.this\npoint, the user can log out or even close the browser /turn\noff the computer. The job will continue to run out_on_the\n\"cloud\" irrespective of what the user is doing on» their\ncomputer.\n\nOn completion of the job, the user will receive an email\nand when logging back into ChRIS, a new feed will be\navailable. By clicking on the feed\\tile, and navigating to\nthe final output directory, the usef can click on the created\ntrk file output, and view thesresults directly in the browser." + }, + { + "id": 75958, + "strid": "a1cca2dd-5865-4275-a6fc-a452b3af6ed3", + "image_id": 203461, + "image_name": "120279.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2602.239, + 1529.616, + 538.469, + 142.06899999999996 + ], + "priority": 12, + "parents": [ + 75967 + ], + "children": [], + "area": 3980426.410224, + "iscrowd": 0, + "segmentation": [], + "text": "A feed canbe expanded into its “Notes”\nWidget which allows for free form notes to be\nadded tothe’ feed. In this way relevant\nobservations, analyses, etc can be immediately\nassociated with the relevant results." + }, + { + "id": 75950, + "strid": "69645f9a-987b-4924-a2f6-40dfb87ca8a7", + "image_id": 203461, + "image_name": "120279.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2536.731, + 1691.811, + 665.25, + 437.10900000000015 + ], + "priority": 13, + "parents": [ + 75967 + ], + "children": [], + "area": 4291669.409841, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 75942, + "strid": "3f34947c-ff94-4174-9519-5c1686ed8037", + "image_id": 203461, + "image_name": "120279.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 84.935, + 1715.593, + 596.4200000000001, + 364.90800000000013 + ], + "priority": 14, + "parents": [ + 75967 + ], + "children": [ + 75964, + 75965 + ], + "area": 145713.891455, + "iscrowd": 0, + "segmentation": [], + "text": "Co\n\nThere are\n\nmany mechanisms Cr é\n\nto collecting MRI data in Op\nChARIS. Within a clinical setting;\n\nperhaps the most obvious method\n\nis by connecting to the existing ca\n\nPACS (Picture Archive and Oo Osh ong S\nSystem) which is a large database designedito." + }, + { + "id": 75964, + "strid": "b156af6d-7c70-48bc-a988-a9e0aef28aeb", + "image_id": 203461, + "image_name": "120279.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 83.848, + 1855.534, + 763.459, + 784.3740000000003 + ], + "priority": 15, + "parents": [ + 75942 + ], + "children": [], + "area": 155582.814832, + "iscrowd": 0, + "segmentation": [], + "text": "There are Ce manage data\nmany mechanisms f transfer and\n‘0 collecting MRI data in Op local/compute\nChARIS. Within a clinical setting;\nperhaps the most obvious method\n\nis by connecting to the existing ca\n\nPACS (Picture Archive and Oo Osh ong S\n\nSystem) which is a large database designedito,\n\nhandle medical image data. In ChR/S click in Plugins search bar\nand type 'pacs_pull'. The plugin icon will change and the plugin UI\nwill present some input parameters. Usually patient data is linked to\na patient Medical Record Number (MRN). Entering the MRN in the\nMRN field and selecting \"Start Job\" will trigger a query to the PACS\nor the passed MRN. The interface will slide open, and a new center\npiece will open containing the results of the query.\n\nThese results can, be’ filtered down by typing in the \"Search\" bar\nprovided. In this manner, it is possible to filter the hits to a given\ndata or imagetype (say MRI Diffusion data) by typing \"Diffusion\" in\nhe searchybar. The results will immediately update showing only\nimages conforming to that search term. By selecting series of\ninterest,.a user can then hit \"Pull Selection\" which will initiate a\nPACS. retrieve and tansfer image data from the PACS to the ChRIS\ninstance.\n\n \n\nThe currently running job (PACS retrieve in this case) will appear as\na new tile in the Activity Feed, and be placed in the \"Running\"" + }, + { + "id": 75965, + "strid": "01b6b1f8-f5fa-431d-a461-97f89a2d2f50", + "image_id": 203461, + "image_name": "120279.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 83.885, + 2640.191, + 187.586, + 191.41800000000012 + ], + "priority": 16, + "parents": [ + 75942 + ], + "children": [], + "area": 221472.422035, + "iscrowd": 0, + "segmentation": [], + "text": "section.\n\nOn completion,\nthe tile will\nautomatically\nbe moved to the\n\"Finished\"\nsection." + }, + { + "id": 75947, + "strid": "6ee8c73f-0f01-4713-9821-97804de8fbf5", + "image_id": 203461, + "image_name": "120279.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 287.695, + 2649.213, + 962.7450000000001, + 551.2000000000003 + ], + "priority": 17, + "parents": [ + 75967 + ], + "children": [], + "area": 762165.3340350001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 75949, + "strid": "8e2d01b8-d598-4dad-81de-74228cd061da", + "image_id": 203461, + "image_name": "120279.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1375.934, + 2023.367, + 1008.5809999999999, + 1136.5599999999997 + ], + "priority": 18, + "parents": [ + 75967 + ], + "children": [], + "area": 2784019.449778, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 75948, + "strid": "2c210eec-79bc-4f4c-9702-ce95c6a0c50f", + "image_id": 203461, + "image_name": "120279.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2597.254, + 2117.194, + 671.9340000000002, + 1010.2559999999999 + ], + "priority": 19, + "parents": [ + 75967 + ], + "children": [], + "area": 5498890.585275999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 75945, + "strid": "bb587e67-9211-4dce-bd7c-346bed95d034", + "image_id": 203461, + "image_name": "120279.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 126.032, + 3208.625, + 1379.273, + 871.491 + ], + "priority": 20, + "parents": [ + 75967 + ], + "children": [], + "area": 404389.426, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 75943, + "strid": "1156cf04-4d62-414a-806d-62f77a2b0682", + "image_id": 203461, + "image_name": "120279.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1507.702, + 3172.244, + 887.4939999999999, + 502.2049999999999 + ], + "priority": 21, + "parents": [ + 75967 + ], + "children": [], + "area": 4782798.623288, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 75960, + "strid": "db1341fe-92a6-403c-83e8-8f2e04ecda28", + "image_id": 203461, + "image_name": "120279.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2381.547, + 3204.091, + 797.0799999999999, + 369.02199999999993 + ], + "priority": 22, + "parents": [ + 75967 + ], + "children": [], + "area": 7630693.308777, + "iscrowd": 0, + "segmentation": [], + "text": "Irrespective of where tiles or feeds,appear, they can be manipulated\nand their contents examined. If welook at any \"Finished\" tile, and click\non it, a file system view will appear. As we drill down the directories, we\ncan see the image data as/it is organized within ChRIS.\n\nAny of the image files.that appear in any feed can be clicked on, and\nthe browser will drop jdown a quick preview of the image. In this\nmanner, a quick_decision can be made as to the data quality and\nsuitability for farther processing. Selecting the \"Slice:Drop\" icon when it\nappears will dispatch a set of image files to a more powerful viewer\ncalled Sli¢e‘Drop. This image will appear in a new tab in the browser\nand, offers:more sophisticated image viewing capabilities." + }, + { + "id": 75961, + "strid": "e180f0fd-7dde-4134-8e85-af9b39687933", + "image_id": 203461, + "image_name": "120279.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1532.842, + 3687.669, + 272.4670000000001, + 311.52300000000014 + ], + "priority": 23, + "parents": [ + 75967 + ], + "children": [], + "area": 5652613.925298, + "iscrowd": 0, + "segmentation": [], + "text": "Medical data\nvisualization in the\nbrowser is based on\nWebGL [3] and ChRIS\nitself is based on the X-\ntoolkit [5]. The\n\northogonal views\nshown are based on\ncode designed\n\noriginally for Slice:Drop\n[4]." + }, + { + "id": 75962, + "strid": "35d076d5-7d87-47d0-b643-65a12dfdbd22", + "image_id": 203461, + "image_name": "120279.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 105.736, + 4085.171, + 1655.024, + 227.50499999999965 + ], + "priority": 24, + "parents": [ + 75967 + ], + "children": [], + "area": 431949.640856, + "iscrowd": 0, + "segmentation": [], + "text": "ion. First, though, it's possible to click on the \"Notes\" part\ned, the \"share\" icon in the feed at the top right (the arrow\nd. ChRIS will then prompt for a username to share the feed\n\nWith the analysis complete, feeds can be shared with other users for additional coll\n\nof the and add some descriptive information about this particular analysis. OG\nicon just.to the right of the feed timestamp) can be used to share the nema\n\n‘SO\nMoreover, real time view sharing is available through the “view” icon oe Multiple users can connect to the same view and all views in\ni Q\n\nifferent browsers are linked. Here, two users are viewing the same n different browsers and their respective mouse pointers are shown i\nthe same scene. The users can realtime “chat” either in text or withvi icrophone. y~" + }, + { + "id": 75946, + "strid": "df910d73-1174-4503-813d-8ddefd067751", + "image_id": 203461, + "image_name": "120279.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1823.772, + 3673.475, + 1398.774, + 885.8020000000001 + ], + "priority": 25, + "parents": [ + 75967 + ], + "children": [], + "area": 6699580.8477, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 75963, + "strid": "0fcfa375-2917-456b-a962-3b49a1376ddc", + "image_id": 203461, + "image_name": "120279.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 338.93, + 4375.605, + 1353.307, + 179.15300000000025 + ], + "priority": 26, + "parents": [ + 75967 + ], + "children": [], + "area": 1483023.80265, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 109976, + "strid": "f374b13e-31d9-4339-b90a-50305df625e0", + "image_id": 204766, + "image_name": "13039.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 161.9, + 362.22, + 319.28, + 268.19999999999993 + ], + "priority": -1, + "parents": [], + "children": [ + 109939, + 109948, + 109947, + 109938, + 109949, + 109942, + 109943, + 109946, + 109941, + 109944, + 109945, + 109940 + ], + "area": 58643.418000000005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 109938, + "strid": "3ff67ae1-dcca-405e-82c4-2f9f49e6580c", + "image_id": 204766, + "image_name": "13039.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 298.696, + 152.371, + 3965.0470000000005, + 53.05600000000001 + ], + "priority": 1, + "parents": [ + 109976 + ], + "children": [], + "area": 45512.60821600001, + "iscrowd": 0, + "segmentation": [], + "text": "EVALUATION OF MOFF AND FLASHLFQ FOR LABEL FREE PEPTIDE QUANTIFICATION IN PROTEOMIC WORKFLOWS WITHIN GALAXY-P FRAMEWORK." + }, + { + "id": 109939, + "strid": "a1dab7b3-4432-4603-8c63-11f5594ea843", + "image_id": 204766, + "image_name": "13039.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 573.09, + 223.831, + 3435.65, + 373.05899999999997 + ], + "priority": 2, + "parents": [ + 109976 + ], + "children": [], + "area": 128275.30779, + "iscrowd": 0, + "segmentation": [], + "text": "Subina Mehta?, Caleb Easterly1, James E.Johnson2, Bjorn Griining?, Andrea Argentini*®, Robert J.Millikin’?, Michael R.Shortreed’, Thomas McGowan/?,\nPraveen Kumar? Lennart Martens*®, Lloyd M.Smith”®, Timothy J.Griffint and Pratik Jagtap+\n\n1Biochemistry, Molecular Biology, and Biophysics, University of Minnesota Twin Cities, Minneapolis; 2Minnesota Supercomputing Institute, University of Minnesota Twin Cities, Minneapolis; 7Bioinformatics\nGroup, Department of Computer Science, University of Freiburg, Freiburg, Baden-Wirttemberg; ¢VIB-UGhent Center for Medical Biotechnology, VIB, Ghent, Belgium, Ghent, Belgium; *Bioinformatics\nInstitute, Ghent, Belgium; \"Department of Biochemistry, Ghent University, Belgium; 7Department of Chemistry, University of Wisconsin, Madison, Wisconsin; 8>Genome Center of Wisconsin, University of\nWisconsin, Madison, Wisconsin; Bioinformatics and Computational Biology, University of Minnesota Twin Cities, Minneapolis" + }, + { + "id": 109940, + "strid": "b5685dbf-b527-41ed-b414-b15bb8218b17", + "image_id": 204766, + "image_name": "13039.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 600.363, + 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"children": [ + 153182, + 153180, + 153181, + 153183, + 153184 + ], + "area": 50, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 153180, + "strid": "577693a3-89fd-4e52-9179-47cf3914cfb4", + "image_id": 206468, + "image_name": "21496.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 68.483, + 26.06, + 616.0520000000001, + 78.989 + ], + "priority": 1, + "parents": [ + 153196 + ], + "children": [], + "area": 1784.66698, + "iscrowd": 0, + "segmentation": [], + "text": "Differential Effect of Electrical Stimuli\non a 3D Bioprinted Model of Inflamed Skin" + }, + { + "id": 153181, + "strid": "3ea7977a-f082-4bb4-a1a0-469757a630e3", + "image_id": 206468, + "image_name": "21496.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 708.552, + 8.749, + 551.023, + 121.237 + ], + "priority": 2, + "parents": [ + 153196 + ], + "children": [], + "area": 6199.121448000001, + "iscrowd": 0, + "segmentation": [], + "text": "Anna Plaksienko®'*, Yuanhua Liu®?, Simona VillaltaS*°, Luigi Manni®, Simeone\nDal Monego’, Margherita Degasperi’, Veronica Ghini®, Leonardo Tenori®,\nDanilo Licastro’, Lucia Napione*®, Francesca Frascella*®, Claudia Angelini’,\n\nChristine Nardini™ Corresponding author:\n\nSIAC CNR “OCBE UiO *CEBSIT ION CAS “PolTo DISAT christine nardini@encit\n\n“PolToBIOMed Lab SIFT CNR \"Area Scionce Park*CERM and DICUS UniFi__ Fist co-author & speaker:\n‘annapla@uio.no" + }, + { + "id": 153182, + "strid": "e87f9a2e-88dc-41dc-9c95-0b4ac72f07e9", + "image_id": 206468, + "image_name": "21496.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 25.651, + 139.296, + 114.581, + 17.464 + ], + "priority": 3, + "parents": [ + 153196 + ], + "children": [ + 153188, + 153186 + ], + "area": 3573.0816959999997, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 153188, + "strid": "ddc948ce-e317-46dc-862f-25cf93d2723b", + "image_id": 206468, + "image_name": "21496.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 23.995, + 177.956, + 171.667, + 181.975 + ], + "priority": 4, + "parents": [ + 153182 + ], + "children": [ + 153195 + ], + "area": 4270.05422, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 153195, + "strid": "639cfbfb-4322-4bd6-8f76-a3d0e8188e59", + "image_id": 206468, + "image_name": "21496.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 23.21, + 365.091, + 170.886, + 58.90100000000001 + ], + "priority": 5, + "parents": [ + 153188 + ], + "children": [], + "area": 8473.76211, + "iscrowd": 0, + "segmentation": [], + "text": "30 construct containing fibroblasts and\nkeratinoctes in a colagen matrix .\nVatata et. ,\n\nBiomedical Science and Engineering\nOnt, voume 4(61)-200" + }, + { + "id": 153186, + "strid": "8f5061fb-6e9b-4d18-86b2-b138fbb3bbc1", + "image_id": 206468, + "image_name": "21496.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 209.408, + 176.333, + 422.2149999999999, + 259.9870000000001 + ], + "priority": 6, + "parents": [ + 153182 + ], + "children": [], + "area": 36925.540863999995, + "iscrowd": 0, + "segmentation": [], + "text": "Electrostimulation is used in a variety of clinical\napproaches, However, magnitude and duration of the\nstimuli are not systematically tested, limiting\nstandardization and mechanisms’ —_elucidation.\n\nConsequently, therapeutic effectiveness _ remains\nunclear.\n\nWe designed 3D bioprinted constructs and explored\nthe effect of the electrical stimulation in inflamed-\nlike and physiological samples, in the absence of\nnervous system, hypothesizing that functions involved in\nthe greater inflammatory pathway (Maturo et al. 2020),\nie wound healing (WH), are at stake." + }, + { + "id": 153183, + "strid": "7c3cdddd-92a1-459f-9d48-26433e4d3fc7", + "image_id": 206468, + "image_name": "21496.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 25.049, + 445.02, + 80.305, + 16.523000000000025 + ], + "priority": 7, + "parents": [ 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"c250b710-88f1-441a-b09a-932de4ce6676", + "image_id": 206468, + "image_name": "21496.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 26.365, + 618.421, + 610.203, + 123.769 + ], + "priority": 10, + "parents": [ + 153184 + ], + "children": [], + "area": 16304.669665, + "iscrowd": 0, + "segmentation": [], + "text": "Preliminary results show that there exists a differential effect of the 5V direct\ncurrent (DC) stimulation versus no stimulus. In this experiment, the magnitude of\nthe effect appears to be more important with DC than AC at 100Hz.\n\nBased on our interest in WH, we focused our attention on the following GSEA\nHallmark gene set, from which we retained development, proliferation, immunity,\nsignaling and pathway categories" + }, + { + "id": 153189, + "strid": "9eb53b47-abe5-40c3-9ce8-91367d11d003", + "image_id": 206468, + "image_name": "21496.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 657.403, + 155.237, + 410.71699999999987, + 179.37700000000004 + ], + "priority": 11, + "parents": [ + 153184 + ], + "children": [], + "area": 102053.269511, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 153194, + "strid": "5a626544-266f-4c3d-be54-5e5db46ed1ad", + "image_id": 206468, + "image_name": "21496.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1077.407, + 160.219, + 214.38100000000009, + 126.71800000000002 + ], + "priority": 12, + "parents": [ + 153184 + ], + "children": [], + "area": 172621.07213299998, + "iscrowd": 0, + "segmentation": [], + "text": "How do different stimuli affect\ninflamed samples?\n\nDe: G proliferative function,\ninflammation associated\nfunctions.\n\nAC: less effective action." + }, + { + "id": 153190, + "strid": "eec6b717-664a-40fb-8908-4e234448777a", + "image_id": 206468, + "image_name": "21496.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 658.751, + 351.491, + 408.18499999999995, + 181.32400000000007 + ], + "priority": 13, + "parents": [ + 153184 + ], + "children": [], + "area": 231545.047741, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 153193, + "strid": "0a6e5207-fbb1-48b0-a09f-279ee4638779", + "image_id": 206468, + "image_name": "21496.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1078.089, + 357.539, + 212.84799999999996, + 140.933 + ], + "priority": 14, + "parents": [ + 153184 + ], + "children": [], + "area": 385458.86297099997, + "iscrowd": 0, + "segmentation": [], + "text": "Is the inflamed sample closer to\nphysiology upon stimulus?\n\nDC: GJ proliferative pathways and\ninflammatory functions, E)\ndevelopment associated functions\nAC: GJ cellular components and\ninflammatory functions,\nproliferation associated functions" + }, + { + "id": 153191, + "strid": "a1bb7e0b-1b2c-41cf-b439-bfd681c05778", + "image_id": 206468, + "image_name": "21496.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 675.309, + 547.269, + 255.73000000000002, + 185.50400000000002 + ], + "priority": 15, + "parents": [ + 153184 + ], + "children": [], + "area": 369575.681121, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 153192, + "strid": "a3cf2209-4a4b-4128-9850-bc5323de5199", + "image_id": 206468, + "image_name": "21496.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1077.975, + 553.599, + 202.827, + 148.81600000000003 + ], + "priority": 16, + "parents": [ + 153184 + ], + "children": [], + "area": 596765.882025, + "iscrowd": 0, + "segmentation": [], + "text": "How do the effects of\ndifferent stimuli differ?\n\nGi functions related to\nproliferation,\n\n© immune response related to\ninflammation and developmental\nfunctions" + }, + { + "id": 116911, + "strid": "af2f7b6a-1b3f-4bba-9aea-e10c583dd388", + "image_id": 205048, + "image_name": "13922.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 89.78, + 97.19, + 407.45000000000005, + 164.19 + ], + "priority": -1, + "parents": [], + "children": [ + 116909, + 116897, + 116898, + 116901, + 116903, + 116905, + 116899 + ], + "area": 8725.7182, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 116897, + "strid": "945cf114-e6b8-4565-8449-e6f38f94dc9e", + "image_id": 205048, + "image_name": "13922.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 183.805, + 476.311, + 3101.584, + 298.093 + ], + "priority": 1, + "parents": [ + 116911 + ], + "children": [], + "area": 87548.343355, + "iscrowd": 0, + "segmentation": [], + "text": "Therapeutic sensations show high similarity between different\nbody-oriented therapies" + }, + { + "id": 116898, + "strid": "fbf7f353-b6e8-48c0-9163-5d2a173db3be", + "image_id": 205048, + "image_name": "13922.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 862.911, + 798.816, + 1773.819, + 158.33899999999994 + ], + "priority": 2, + "parents": [ + 116911 + ], + "children": [], + "area": 689307.113376, + "iscrowd": 0, + "segmentation": [], + "text": "Florian Beissner'\n\n\"Somatosensory and Autonomic Therapy Research, Hannover Medical School, Hannover, Germany" + }, + { + "id": 116899, + "strid": "55ecf221-8e2c-44e2-9548-9e63df927561", + "image_id": 205048, + "image_name": "13922.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 58.403, + 1010.665, + 268.577, + 63.83600000000001 + ], + "priority": 3, + "parents": [ + 116911 + ], + "children": [ + 116900 + ], + "area": 59025.86799499999, + "iscrowd": 0, + "segmentation": [], + "text": "Question:" + }, + { + "id": 116900, + "strid": "e9999ff9-e760-4bd5-b2cf-47d9b52155dd", + "image_id": 205048, + "image_name": "13922.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 54.396, + 1090.939, + 1641.596, + 615.598 + ], + "priority": 4, + "parents": [ + 116899 + ], + "children": [], + "area": 59342.717844000006, + "iscrowd": 0, + "segmentation": [], + "text": "Complex bodily sensations that patients experience during\ntherapeutic interventions are a common phenomenon in many\nbody-oriented therapies. Despite the striking similarity of\nsensations across different therapy systems, no attempt has been\nmade so far to understand their characteristics and clinical\nrelevance from a perspective that transcends the borders between\nthese systems." + }, + { + "id": 116903, + "strid": "ff76b329-890a-4c9b-ab45-c9d3d84a02ac", + "image_id": 205048, + "image_name": "13922.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 58.902, + 1808.111, + 266.204, + 65.0139999999999 + ], + "priority": 5, + "parents": [ + 116911 + ], + "children": [ + 116904 + ], + "area": 106501.354122, + "iscrowd": 0, + "segmentation": [], + "text": "Methods:" + }, + { + "id": 116904, + "strid": "8ad0ee5e-8eb8-4a31-bd90-07ad1235af74", + "image_id": 205048, + "image_name": "13922.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 52.392, + 1894.09, + 1642.009, + 1052.052 + ], + "priority": 6, + "parents": [ + 116903 + ], + "children": [], + "area": 99235.16328000001, + "iscrowd": 0, + "segmentation": [], + "text": "We searched the pubmed database for the terms ‘therapeutic\nsensation’, ‘deqi’, ‘needling sensation’, ‘enhanced touch sensation’,\n‘acupuncture sensation’, ‘propagated sensation’, and alternative\nspellings thereof. We identified 311 studies of which we included\nthose that reported verbal descriptors together with their relative\nfrequencies, i.e. information on how often each descriptor had\nbeen used by subjects to describe their TS. To reflect both within-\nand between-study variance we first calculated relative frequencies\nfor each of the descriptors used in the single studies. We then\nmultiplied these frequencies by the weighting factor n/27, where n\nwas the number of studies reporting the descriptor at least once.\nThe results were transformed into a word cloud." + }, + { + "id": 116905, + "strid": "b464d336-24da-4bac-aebf-c347e1ccedff", + "image_id": 205048, + "image_name": "13922.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 58.765, + 3047.866, + 220.277, + 58.59900000000016 + ], + "priority": 7, + "parents": [ + 116911 + ], + "children": [ + 116906 + ], + "area": 179107.84549, + "iscrowd": 0, + "segmentation": [], + "text": "Results:" + }, + { + "id": 116906, + "strid": "5724fb61-5103-4d6b-9d20-be2539ad4945", + "image_id": 205048, + "image_name": "13922.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 53.756, + 3133.25, + 1642.133, + 970.2550000000001 + ], + "priority": 8, + "parents": [ + 116905 + ], + "children": [], + "area": 168430.987, + "iscrowd": 0, + "segmentation": [], + "text": "Our final sample consisted of 27 studies which comprised different\nacupuncture modalities (manual, electric, auricular, laser), tactile\nstimulation, focused ultrasound as well as various sham or placebo\ninterventions. We found that the terms which are most frequently\nused to describes therapeutic sensations across various fields were\n‘numbness’ (37.6), ‘tingling’ (36.4), and ‘soreness’ (31.4), followed\nby ‘heaviness’ (24.0), ‘dull pain’ (23.4), ‘aching’ (22.1), ‘fullness’\n(21.1), ‘sharp pain’ (18.6), ‘pressure’ (15.1), ‘distension’ (13.7),\n‘warmth’ (13.3), ‘throbbing’ (10.6) and ‘spreading’ (7.4), where the\nnumbers in brackets denote the product of mean and weighting\nfactor (Figure 1)." + }, + { + "id": 116901, + "strid": "b0f14c7b-4843-45e3-b088-f54f254eace1", + "image_id": 205048, + "image_name": "13922.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1739.151, + 1005.827, + 344.22799999999984, + 57.442999999999984 + ], + "priority": 9, + "parents": [ + 116911 + ], + "children": [ + 116907, + 116902 + ], + "area": 1749285.032877, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions:" + }, + { + "id": 116902, + "strid": "cf68314a-1d62-4e33-8700-77a0b4a71c37", + "image_id": 205048, + "image_name": "13922.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1733.457, + 1090.753, + 1685.6120000000003, + 786.26 + ], + "priority": 10, + "parents": [ + 116901 + ], + "children": [], + "area": 1890773.423121, + "iscrowd": 0, + "segmentation": [], + "text": "Sensations experienced during therapeutic interventions are highly\nsimilar in their qualitative nature across different modes of\nstimulation and therapies. Since no generally accepted scientific term\nexists for this phenomenon, we propose the term therapeutic\nsensations for it. Therapeutic sensations may be a thread linking\nseemingly unrelated therapy systems and even explain some pre-\nscientific concepts, like the meridians of Traditional Chinese Medicine\nor the idea of some form of energy exchange between practitioner\n\nand patient. dietnanainn" + }, + { + "id": 116907, + "strid": "39982ad2-5ab8-4e67-a31f-cb63d30decfb", + "image_id": 205048, + "image_name": "13922.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1723.056, + 1804.3, + 1692.574, + 1116.0220000000002 + ], + "priority": 11, + "parents": [ + 116901 + ], + "children": [ + 116908 + ], + "area": 3108909.9408, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 116908, + "strid": "aa1c3168-dbd0-4001-8e5c-83a18fe7ea6b", + "image_id": 205048, + "image_name": "13922.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1733.123, + 2927.75, + 1701.9860000000003, + 294.20899999999983 + ], + "priority": 12, + "parents": [ + 116907 + ], + "children": [], + "area": 5074150.86325, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1: A word cloud of the all verbal descriptors identified in our meta-analysis of studies\nreporting therapeutic sensations. Font size encodes frequency ranging from 37.6 (numbness)\nto 0.48 (fading). Because not all studies reported all descriptors, relative frequencies from the\nsingle studies were averaged and weighted by the number of studies reporting the respective\ndescriptor." + }, + { + "id": 116909, + "strid": "1affb59c-a2ef-4636-bf9e-824cfc4d435d", + "image_id": 205048, + "image_name": "13922.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1737.216, + 3261.813, + 325.0390000000002, + 60.78699999999981 + ], + "priority": 13, + "parents": [ + 116911 + ], + "children": [ + 116910 + ], + "area": 5666473.732608, + "iscrowd": 0, + "segmentation": [], + "text": "References:" + }, + { + "id": 116910, + "strid": "2dd7ee9e-1096-4337-87cf-c9ee640afd4d", + "image_id": 205048, + "image_name": "13922.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1733.596, + 3342.758, + 1680.8610000000003, + 856.5050000000001 + ], + "priority": 14, + "parents": [ + 116909 + ], + "children": [], + "area": 5794991.897768, + "iscrowd": 0, + "segmentation": [], + "text": "Bai et al. Hum Brain Mapp. 2009;30(11):3445-60; Bai et al. Mol Pain. 2010;6:73; Bai et al. J\nMagn Reson Imaging. 2010;31(1):71-7; Beissner et al. CAM. 2012:591304; Beissner et al.\nPLoS One. 2015;10(4):e0124808; Chen et al. eCAM. 2013:538476; Feng et al. J Magn\nReson Imaging. 2011;34(1):31-42; Huang et al. eCAM. 2012:157989; Huang et al. eCAM.\n2013:856905; Hui et al. Neuroimage. 2005;27(3):479-96; Hui et al. BMC CAM. 2007;7:33;\nLoyeung et al. eCAM. 2013:136763; Kong et al. J Pain. 2005;6(1):55-64; Napadow et al.\nNeuroimage. 2009;47(3):1055-65; Park et al. Am J Chin Med. 2002;30(1):45-50; Park et al.\nAltern Complement Med. 2009; 15(12):1275-83; Park et al. Acupunct Med. 2011;29(4):257-\n65; Qin et al. Mol Pain. 2011:7:19; Salih et al. BMC CAM. 2010;10:81; Shi et al. BMC CAM.\n2014;14:69; Spaeth et al. eCAM. 2013:204259: Wang et al. Pain Med. 2012; 13(5):623-30;\nWang et al. eCAM. 2013:371543: Wang et al. eCAM. 2013:483105; White et al. JACM.\n2008; 14(4):373-9; Yoo et al. Complement Ther Med. 2014;22(4):592-600; Yuan et al.\neCAM. 2013:430851; Zhou et al. JACM. 2011;17(11):1007-13;" + }, + { + "id": 49632, + "strid": "dae7a3d6-f1a7-4e0c-9bee-4e612bd1b1ef", + "image_id": 202447, + "image_name": "118707.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 40.28, + 35.99, + 35.459999999999994, + 38.410000000000004 + ], + "priority": -1, + "parents": [], + "children": [ + 49631, + 49630 + ], + "area": 1449.6772, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 49630, + "strid": "e658ca52-1f22-4494-9422-a31783a65408", + "image_id": 202447, + "image_name": "118707.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 92.161, + 134.968, + 321.767, + 19.46799999999999 + ], + "priority": 1, + "parents": [ + 49632 + ], + "children": [], + "area": 12438.785848, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 49631, + "strid": "86f1d821-9884-4ae2-8af1-5b6b892359d2", + "image_id": 202447, + "image_name": "118707.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 85.255, + 197.739, + 928.587, + 432.84799999999996 + ], + "priority": 2, + "parents": [ + 49632 + ], + "children": [], + "area": 16858.238445, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 104413, + "strid": "3fc2cc94-3cf0-420a-bd2a-82ce034e25e1", + "image_id": 204534, + "image_name": "122298.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 155.64, + 427.57, + 294.88, + 327.64000000000004 + ], + "priority": -1, + "parents": [], + "children": [ + 104369, + 104370, + 104392, + 104399, + 104375, + 104406, + 104382, + 104372, + 104393, + 104395, + 104394, + 104396, + 104398, + 104371 + ], + "area": 66546.99479999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 104369, + "strid": "1e84624e-d16f-442e-b48a-ac79938c6b6a", + "image_id": 204534, + "image_name": "122298.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 250.961, + 222.127, + 3035.3639999999996, + 198.47999999999996 + ], + "priority": 1, + "parents": [ + 104413 + ], + "children": [], + "area": 55745.21404700001, + "iscrowd": 0, + "segmentation": [], + "text": "Estimation ofrenal function using the Cockroft-Gault, CKD-EPI and MDRD\nin chronic kidney disease patients not on renal replacement therapy" + }, + { + "id": 104370, + "strid": "e9f27d70-1b8a-4cb0-8787-45612f958c5c", + "image_id": 204534, + "image_name": "122298.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 894.402, + 427.282, + 1762.4700000000003, + 144.541 + ], + "priority": 2, + "parents": [ + 104413 + ], + "children": [], + "area": 382161.875364, + "iscrowd": 0, + "segmentation": [], + "text": "Andronesi A’, Ismai[G\", Iliuta L-, Gamala A’, Balanica S’\n’Department of Nephrology, Fundehi Clinical Institute, UMF Carol Davila, Bucharest, ROMANIA\n2Medical Informatics and Biostatistics Department, UMF Carol Davila, Bucharest, ROMANIA" + }, + { + "id": 104375, + "strid": "ff7a64ea-cdc1-4207-83f0-b8b3abd44a2c", + "image_id": 204534, + "image_name": "122298.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 171.143, + 870.7, + 402.88699999999994, + 62.37199999999996 + ], + "priority": 3, + "parents": [ + 104413 + ], + "children": [ + 104376, + 104380, + 104374 + ], + "area": 149014.2101, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 104374, + "strid": "b838e4de-0b1b-4b5d-a4d1-864c1a8a3bd0", + "image_id": 204534, + "image_name": "122298.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 171.143, + 970.158, + 866.46, + 721.4880000000002 + ], + "priority": 4, + "parents": [ + 104375 + ], + "children": [], + "area": 166035.750594, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 104376, + "strid": "ae70bb6e-86e7-4765-9301-4dadd8ae6193", + "image_id": 204534, + "image_name": "122298.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 261.263, + 1690.7, + 762.7920000000001, + 532.4190000000001 + ], + "priority": 5, + "parents": [ + 104375 + ], + "children": [ + 104379 + ], + "area": 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"122298.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 174.491, + 2724.108, + 571.794, + 55.278999999999996 + ], + "priority": 8, + "parents": [ + 104413 + ], + "children": [ + 104387 + ], + "area": 475332.32902800007, + "iscrowd": 0, + "segmentation": [], + "text": "Cockroft-Gault Formula" + }, + { + "id": 104387, + "strid": "dabdc8ad-70e9-43d3-a0fa-caa94d3122f8", + "image_id": 204534, + "image_name": "122298.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 175.31, + 2798.03, + 814.616, + 82.07900000000018 + ], + "priority": 9, + "parents": [ + 104396 + ], + "children": [], + "area": 490522.63930000004, + "iscrowd": 0, + "segmentation": [], + "text": "Cler (mi/min)=(140-Age)xWeight(kg)x0.85 (if F)/72xScr\n(mg/dl)" + }, + { + "id": 104395, + "strid": "a5d4fb23-d318-48b9-8483-623358884de7", + "image_id": 204534, + "image_name": "122298.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 177.946, + 2910.676, + 544.155, + 51.82400000000007 + ], + "priority": 10, + "parents": [ + 104413 + ], + "children": [ + 104388 + ], + "area": 517943.151496, + "iscrowd": 0, + "segmentation": [], + "text": "MDRD Study Equation" + }, + { + "id": 104388, + "strid": "d7409d5a-b361-4df1-889d-1d48d9ce7f4a", + "image_id": 204534, + "image_name": "122298.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 179.634, + 2989.072, + 864.8989999999999, + 77.04300000000012 + ], + "priority": 11, + "parents": [ + 104395 + ], + "children": [], + "area": 536938.959648, + "iscrowd": 0, + "segmentation": [], + "text": "GFR (mi/min/1.73m*)=175xStand.Scer (mg/dl) *'°*¥xAge?*%\nx0.742 (if F)x1.210 (if black)" + }, + { + "id": 104394, + "strid": "84fba7cd-2fbf-4734-9f12-56d537e217a4", + "image_id": 204534, + "image_name": "122298.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 176.219, + 3100.698, + 440.5059999999999, + 57.00700000000006 + ], + "priority": 12, + "parents": [ + 104413 + ], + "children": [ + 104389 + ], + "area": 546401.900862, + "iscrowd": 0, + "segmentation": [], + "text": "CKD-EPI Equation" + }, + { + "id": 104389, + "strid": "e745df8d-d055-44a9-ae06-922c38b98041", + "image_id": 204534, + "image_name": "122298.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 176.608, + 3179.894, + 864.511, + 140.48399999999992 + ], + "priority": 13, + "parents": [ + 104394 + ], + "children": [], + "area": 561594.7195519999, + "iscrowd": 0, + "segmentation": [], + "text": "GFR (mi/min/1.73m*)=141xmin(Scet/x, 1)“xmax(Scer/x, 1)\"-%\nx0.993 49°x1.018 (if F)x1.157 (if black),\n\nwhere: x is 0.7 (F)/0.9(M); A is-0.329(F)/-0.411(M)" + }, + { + "id": 104392, + "strid": "72d071d5-901c-4cf9-9cfb-440a77f33168", + "image_id": 204534, + "image_name": "122298.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 177.946, + 3351.182, + 863.7379999999999, + 57.00700000000006 + ], + "priority": 14, + "parents": [ + 104413 + ], + "children": [ + 104390 + ], + "area": 596329.432172, + "iscrowd": 0, + "segmentation": [], + "text": "CKD-EPI Serum Cystatin C Equation" + }, + { + "id": 104390, + "strid": "179055e0-0883-468c-850f-29a38188ca19", + "image_id": 204534, + "image_name": "122298.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 176.219, + 3422.009, + 728.9949999999999, + 88.10100000000011 + ], + "priority": 15, + "parents": [ + 104392 + ], + "children": [], + "area": 603023.003971, + "iscrowd": 0, + "segmentation": [], + "text": "GFR (ml/min/1.73m?)=133xmin(Scys/0. 8, 1)°499x\nmax(Scys/0.8, 1)-138 x0.996 49°x0.932 (if F)" + }, + { + "id": 104393, + "strid": "e47c8391-7fd6-4e54-84cb-a135f1a113d7", + "image_id": 204534, + "image_name": "122298.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 179.674, + 3534.295, + 808.459, + 63.916999999999916 + ], + "priority": 16, + "parents": [ + 104413 + ], + "children": [ + 104391 + ], + "area": 635020.91983, + "iscrowd": 0, + "segmentation": [], + "text": "CKD-EPI SCys and SCrc Equation" + }, + { + "id": 104391, + "strid": "76e206cd-aba1-4833-8d4e-e5f3417b17dd", + "image_id": 204534, + "image_name": "122298.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 169.309, + 3613.758, + 881.0130000000001, + 186.567 + ], + "priority": 17, + "parents": [ + 104393 + ], + "children": [], + "area": 611841.753222, + "iscrowd": 0, + "segmentation": [], + "text": "GFR (mi/min/1.73m2)=135xmin(Scr/x, 1)“xmax(Sct/k, 1)?!\nxmin(Scys/0.8, 1)-°37°x max(Scys/0.8, 1)-°-711x0.995 49°\nx0.969 (if F)x1.08 (if black)\n\nwhere: « is 0.7 (F)/0.9(M); 4 is-0.329(F)/-0.411(M)" + }, + { + "id": 104398, + "strid": "31ce3616-8618-446a-b7e3-e789d71b4463", + "image_id": 204534, + "image_name": "122298.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 148.644, + 3930.714, + 343.503, + 71.37699999999995 + ], + "priority": 18, + "parents": [ + 104413 + ], + "children": [ + 104397 + ], + "area": 584277.051816, + "iscrowd": 0, + "segmentation": [], + "text": "Objectives" + }, + { + "id": 104397, + "strid": "b9da0919-aaac-44e6-969c-55c07ca4cee0", + "image_id": 204534, + "image_name": "122298.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 144.183, + 4070.494, + 950.2080000000001, + 324.1709999999998 + ], + "priority": 19, + "parents": [ + 104398 + ], + "children": [], + "area": 586896.036402, + "iscrowd": 0, + "segmentation": [], + "text": "To assess the acuracy of different formula-\nbased equations for renal function\ncompared with measurement of creatinin\nclearance in CKD patients not on renal\nreplacement." + }, + { + "id": 104371, + "strid": "7369d812-dfe1-4438-898b-fe70ef260d3e", + "image_id": 204534, + "image_name": "122298.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1319.118, + 858.9, + 281.5149999999999, + 65.74300000000005 + ], + "priority": 20, + "parents": [ + 104413 + ], + "children": [ + 104373, + 104381, + 104377 + ], + "area": 1132990.4501999998, + "iscrowd": 0, + 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Comparison between CrC/ and CKD-EPI\n\nFig. 5: Bland-Altman plot- difference CrCl-CKD-EPI vs. mean between\nCrCl and CKD-EPI\n\nTable 3: Accuracy of GFR formula in elderly patients\nTable 4: Accuracy of GFR formula in obese patients" + }, + { + "id": 104384, + "strid": "8669315a-6107-468b-a06c-bcd86f62f25c", + "image_id": 204534, + "image_name": "122298.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1785.14, + 2665.094, + 412.9660000000001, + 274.7420000000002 + ], + "priority": 28, + "parents": [ + 104382 + ], + "children": [], + "area": 4757565.90316, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 104386, + "strid": "c04eb6e1-e93c-4e5c-8e60-09a26cc118dd", + "image_id": 204534, + "image_name": "122298.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1334.632, + 2972.259, + 406.1399999999999, + 279.8609999999999 + ], + "priority": 29, + "parents": [ + 104382 + ], + "children": [], + "area": 3966871.9736880003, + "iscrowd": 0, + 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[], + "text": "Fig.6: Comparison between GFR estimation formula depending on\nCKD stages" + }, + { + "id": 104405, + "strid": "177baaa1-63b9-4601-9fb3-ca32270d275d", + "image_id": 204534, + "image_name": "122298.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2462.705, + 3133.487, + 945.3360000000002, + 355.6869999999999 + ], + "priority": 40, + "parents": [ + 104372 + ], + "children": [], + "area": 7716854.102335, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 104406, + "strid": "8f78cbe6-96c8-493e-b25f-28e89ba27f08", + "image_id": 204534, + "image_name": "122298.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2495.902, + 3672.55, + 406.27300000000014, + 60.072000000000116 + ], + "priority": 41, + "parents": [ + 104413 + ], + "children": [ + 104404 + ], + "area": 9166324.8901, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 104404, + "strid": "13bf8741-dcd1-40c8-aad1-dc39bf38aa6f", + "image_id": 204534, + 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Lener’, Edmund Wong’, Cheuk Y. Tang’, William Byne’*5, Kim E. Goldstein’, Nicholas J. Blair*-,\nM. Mehmet Haznedar', Antonia S. New’, Eran Chemerinski'™-5, King-Wai Chu*4, Liza S. Rimsky’,\nLarry J. Siever'*5, Harold W. Koenigsberg'», and Erin A. Hazlett'>4\n\n1Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY\n2Translational and Molecular Imaging Institute, Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY\n3Mental IlIness Research, Education, and Clinical Center (MIRECC VISN 3), James J. Peters Veterans Affairs Medical Center, Bronx, NY\n4Research and Development, James J. Peters Veterans Affairs Medical Center, Bronx, NY\n5Department of Outpatient Psychiatry, James J. 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"segmentation": [], + "text": "FIGURES: Diagnostic Group x Hemisphere interaction\n(Averaged across white matter tracts (Cingulum, ILF, and=ALIC)),\nF[2M 23]=5.79, p<0.01, Wilks, post-hocs are shown below" + }, + { + "id": 64119, + "strid": "0abe4a6e-0941-4b96-b83b-50c30658e95a", + "image_id": 203022, + "image_name": "119593.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3793.868, + 990.982, + 931.7260000000001, + 1786.016 + ], + "priority": 20, + "parents": [ + 64106 + ], + "children": [ + 64124 + ], + "area": 3759654.8983759996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 64124, + "strid": "60e77181-009f-4980-964c-ff8e6b67d291", + "image_id": 203022, + "image_name": "119593.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 3798.456, + 888.72, + 907.4089999999997, + 82.83899999999994 + ], + "priority": 21, + "parents": [ + 64119 + ], + "children": [], + "area": 3375763.81632, + "iscrowd": 0, + "segmentation": [], + "text": "FIGURE 4: Relationship between WM FA (in @C Genu and\nILF) and clinical symptom severity in SPD and SZ" + }, + { + "id": 64116, + "strid": "b8635092-30dc-48be-8d1d-b05e6404feaf", + "image_id": 203022, + "image_name": "119593.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2228.459, + 2888.037, + 387.8620000000001, + 55.2829999999999 + ], + "priority": 22, + "parents": [ + 64129 + ], + "children": [ + 64115 + ], + "area": 6435872.044982999, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 64115, + "strid": "a949ae93-7b94-4784-b6f2-f23a30d9fe80", + "image_id": 203022, + "image_name": "119593.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1334.836, + 3010.627, + 2147.469, + 406.02300000000014 + ], + "priority": 23, + "parents": [ + 64116 + ], + "children": [], + "area": 4018693.302172, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 64117, + "strid": "5bd34b20-d7ff-4f50-a65c-bdc34dac25e7", + "image_id": 203022, + "image_name": 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19217, + 19215, + 19214 + ], + "area": 630.6999999999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 19213, + "strid": "0830dfb8-cdd0-446e-9106-550f7fe145ed", + "image_id": 201258, + "image_name": "116832.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 123.887, + 83.26, + 1176.901, + 49.84000000000002 + ], + "priority": 1, + "parents": [ + 19221 + ], + "children": [], + "area": 10314.83162, + "iscrowd": 0, + "segmentation": [], + "text": "Coagulation Monitoring - not always Gold and Shining" + }, + { + "id": 19214, + "strid": "343fbd77-7a80-43e7-95f3-2e61f43a5055", + "image_id": 201258, + "image_name": "116832.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 324.218, + 158.02, + 717.104, + 43.496999999999986 + ], + "priority": 2, + "parents": [ + 19221 + ], + "children": [], + "area": 51232.928360000005, + "iscrowd": 0, + "segmentation": [], + "text": "Rolf Huet, Vlado Cernak, Christopher Gallandat\npt of Anesthesia, University Medical Center Groningen, Groningen, The Netherlan|" + }, + { + "id": 19215, + "strid": "8e51b092-b693-4156-9c3e-3fc8ad0a4f9a", + "image_id": 201258, + "image_name": "116832.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 110.368, + 270.243, + 1196.335, + 78.935 + ], + "priority": 3, + "parents": [ + 19221 + ], + "children": [], + "area": 29826.179423999998, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction. Thromboelastometry and Multiplate platelet function monitoring are both used for coagulation monitoring in cardiac surgery. The complementary value of the two\n\nmonitoring systems is not established. In the RoTEM full whole blood coagulation (ExTEM) as well as the plasmatic component (FibTEM, where Cytochalasin D inhibits platelet\n\nfunction) is measured. Subtraction of both measurements (ExTEM-FibTEM, panel A&B) should reflect the contribution of platelets to coagulation and clot strength. For this\nbservational study we assessed the contribution of platelets to maximum clot strength in relation to fibrinogen and the platelet aggregatory responses with the Multiplate® ." + }, + { + "id": 19216, + "strid": "b74440af-7d8b-47ef-8471-427f808ff4fc", + "image_id": 201258, + "image_name": "116832.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 109.931, + 369.974, + 1188.334, + 96.93900000000002 + ], + "priority": 4, + "parents": [ + 19221 + ], + "children": [], + "area": 40671.611794, + "iscrowd": 0, + "segmentation": [], + "text": "Methods. Twenty six elective cardiac surgery patients were included after informed consent and institutional review board approval. Clotting samples were assessed before and\nafter cardiopulmonary bypass. In the Multiplate three activators were used: 20 jl ADP, 50 1! Ristocetin (to test platelet adhesion) and 20 il TRAP. For comparison in the RoTEM\nclot strength, defined as maximum clot elasticity (MCE), was calculated from maximal clot firmness to accomodate for Hooke’s law. MCE = (100 x MCF)/(100-MCF) dyne cm\nin ExTEM and FibTEM!2. The platelet contribution to clot strength is then given by subtraction: MCEplaes = MCEextem - MCErisren (Lang, 2009). Patient samples after\ninduction (TO) and at the end of operation (T4) were included." + }, + { + "id": 19220, + "strid": "3d399090-a55b-4cbf-ab1a-69b446e08f26", + "image_id": 201258, + "image_name": "116832.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 110.84, + 489.656, + 1203.232, + 266.892 + ], + "priority": 5, + "parents": [ + 19221 + ], + "children": [], + "area": 54273.471040000004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 19217, + "strid": "acb8fb30-2e84-46fa-a2fd-77a638c6ed15", + "image_id": 201258, + "image_name": "116832.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 109.527, + 791.774, + 1201.675, + 56.15499999999997 + ], + "priority": 6, + "parents": [ + 19221 + ], + "children": [], + "area": 86720.630898, + "iscrowd": 0, + "segmentation": [], + "text": "Results. We found no correlation between the MCEplatelets and any of the Multiplate activators (ADP r = 0.236, fig. 1, Risto r= 0.2, and TRAP 08). There was also no relation\nwith thrombocytes count (r=0.185, fig 2). However, we did find a strong relation between the fibrinogen level and the MCEpiaes both at the start and at the end of operation (r=\n0.80, P=<0.001, fig. 3). Platelet count decreased at the end of operation (202 +47 vs 133 + 35 10°/L)." + }, + { + "id": 19218, + "strid": "20469609-ff44-416c-ab88-bfc236aa59f2", + "image_id": 201258, + "image_name": "116832.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 109.489, + 883.002, + 1179.021, + 78.03399999999999 + ], + "priority": 7, + "parents": [ + 19221 + ], + "children": [], + "area": 96679.005978, + "iscrowd": 0, + "segmentation": [], + "text": "iscussion and Conclusion. |. We found no relation between platelet contribution to clot strength, as measured by ROTEM and platelet function testing with the Multiplate. 2.\nInterestingly, fibrinogen improved the platelet contribution of clot strength in RoOTEM measurements. It seems therefore doubtful whether the MCEpiacie, can be regarded as a\nmeasure of thrombocyte function. In ordinary cardiac surgery patients, we confirm the results as described by Lang et al? in vitro and in thrombopenic patients. In addition this\nstudy suggests, that to assess platelet function next to ROTEM measurements, a complementary platelet function test, ie. the Multiplate, will be necessary." + }, + { + "id": 19219, + "strid": "f27b7cdf-b4d8-4471-9d22-2871ddd2cd6c", + "image_id": 201258, + "image_name": "116832.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 109.081, + 1025.683, + 815.504, + 17.096000000000004 + ], + "priority": 8, + "parents": [ + 19221 + ], + "children": [], + "area": 111882.527323, + "iscrowd": 0, + "segmentation": [], + "text": "Literature |. Nielsen VG, et al Acta Anesthest Scand 2005: 49; 222-232. 2. Lang T et al. Anesth Analg 2009; 108: 751-8." + }, + { + "id": 16474, + "strid": "9f372926-1db8-4a5b-a891-291073c05efb", + "image_id": 201150, + "image_name": "116674.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 180.91, + 178.89, + 252.64000000000001, + 260.79 + ], + "priority": -1, + "parents": [], + "children": [ + 16458, + 16470, + 16460, + 16462, + 16469, + 16459, + 16461 + ], + "area": 32362.989899999997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 16458, + "strid": "505fffb4-76be-4cb4-9a2f-5ed650249d9e", + "image_id": 201150, + "image_name": "116674.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 685.975, + 201.423, + 1939.219, + 88.01300000000003 + ], + "priority": 1, + "parents": [ + 16474 + ], + "children": [], + "area": 138171.142425, + "iscrowd": 0, + "segmentation": [], + "text": "Genome-wide Enhanced Gene Regulatory Networks" + }, + { + "id": 16459, + "strid": "94449cae-50b6-4ffc-9275-7bc4db973dad", + "image_id": 201150, + "image_name": "116674.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 839.717, + 340.412, + 1636.3089999999997, + 116.344 + ], + "priority": 2, + "parents": [ + 16474 + ], + "children": [], + "area": 285849.74340399995, + "iscrowd": 0, + "segmentation": [], + "text": "A. Benso, S.Di Carlo, G. Politano, A. Savino, and H. 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The\nnodes interact and their state changes as a result of\nthese interactions.\n\nOne of the simplest models of a dynamical network is\nthe Boolean network.\n\nA Boolean network is directed, and each node is in one\nof two states, 0 or 1.\n\nFurthermore, each node has a set of rules which tell it its\nstate depending on the states of its neighbours in the\nnetwork." + }, + { + "id": 16462, + "strid": "43953f48-8440-43ac-9e91-79a772a40a08", + "image_id": 201150, + "image_name": "116674.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 374.281, + 2372.468, + 386.16399999999993, + 43.02500000000009 + ], + "priority": 7, + "parents": [ + 16474 + ], + "children": [ + 16466, + 16465, + 16473, + 16471 + ], + "area": 887969.695508, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 16465, + "strid": "fc0d9c9a-0bca-4544-a783-485029507b0e", + "image_id": 201150, + "image_name": "116674.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 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"df1314e2-d393-4add-8d33-845c56deed72", + "image_id": 206088, + "image_name": "17398.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 737.63, + 38.385, + 3348.825, + 218.168 + ], + "priority": 1, + "parents": [ + 143839 + ], + "children": [], + "area": 28313.927549999997, + "iscrowd": 0, + "segmentation": [], + "text": "MEDFORD-RNASea: A human and machine readable markup language to\nfacilitate FAIR coral metadata" + }, + { + "id": 143814, + "strid": "185676e7-5cfa-4ac2-9730-7377bd84f23d", + "image_id": 206088, + "image_name": "17398.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1457.737, + 293.976, + 1888.5609999999997, + 233.24599999999998 + ], + "priority": 2, + "parents": [ + 143839 + ], + "children": [], + "area": 428539.692312, + "iscrowd": 0, + "segmentation": [], + "text": "John Freeman, Jill Ashey, Polina Shpilker, Hailey McKelvie, Hollie M. Putnam,\nJane Greenberg, Lenore J. Cowen, Alva Couch, Noah Daniels\nTufts University, Drexel University, University of Rhode Island" + }, + { + "id": 143815, + "strid": "0c67f5d8-4077-4f43-b39c-4c5ce602aedb", + "image_id": 206088, + "image_name": "17398.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 220.822, + 606.157, + 857.3849999999999, + 164.49400000000003 + ], + "priority": 3, + "parents": [ + 143839 + ], + "children": [ + 143824 + ], + "area": 133852.801054, + "iscrowd": 0, + "segmentation": [], + "text": "Coral Researchers collect\ndiverse data worldwide" + }, + { + "id": 143824, + "strid": "bed6afb6-a63f-438c-98bf-63e4a953245f", + "image_id": 206088, + "image_name": "17398.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 128.065, + 814.9, + 1007.6679999999999, + 205.19600000000003 + ], + "priority": 4, + "parents": [ + 143815 + ], + "children": [], + "area": 104360.1685, + "iscrowd": 0, + "segmentation": [], + "text": "Coral researchers collect genomic data using\ntechnologies such as RNASeq, but also other kinds\nof data, including still images, video, and physical\nmeasurements [1,2]." + }, + { + "id": 143816, + "strid": "ea3d51d8-cc40-4bdf-b28d-af917881bedf", + "image_id": 206088, + "image_name": "17398.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 114.226, + 1144.565, + 1073.469, + 163.63900000000012 + ], + "priority": 5, + "parents": [ + 143839 + ], + "children": [ + 143825 + ], + "area": 130739.08169, + "iscrowd": 0, + "segmentation": [], + "text": "These data associate with even\nmore diverse metadata" + }, + { + "id": 143825, + "strid": "31fc9801-79c9-4489-aec3-b36085da2389", + "image_id": 206088, + "image_name": "17398.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 137.06, + 1349.653, + 1051.56, + 358.4370000000001 + ], + "priority": 6, + "parents": [ + 143816 + ], + "children": [], + "area": 184983.44018, + "iscrowd": 0, + "segmentation": [], + "text": "Any data collected by a coral researcher associates\nwith a wide variety of metadata: geographical\nlocation, temperature and other environmental\nconditions, species - but also, the technologies used\nto collect the data, affiliations and identities of the\nresearchers, publication venues, and the location of\nthe data." + }, + { + "id": 143817, + "strid": "83bb3399-e3c9-4838-b094-cd67ca242b8f", + "image_id": 206088, + "image_name": "17398.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 112.91, + 1802.52, + 1082.04, + 173.3520000000001 + ], + "priority": 7, + "parents": [ + 143839 + ], + "children": [ + 143826 + ], + "area": 203522.5332, + "iscrowd": 0, + "segmentation": [], + "text": "Some repositories require coral\nmetadata to be deposited" + }, + { + "id": 143826, + "strid": "25948f01-3708-4141-852c-a477b8177b8f", + "image_id": 206088, + "image_name": "17398.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 141.102, + 2061.169, + 1040.877, + 367.09500000000025 + ], + "priority": 8, + "parents": [ + 143817 + ], + "children": [], + "area": 290835.068238, + "iscrowd": 0, + "segmentation": [], + "text": "The National Science Foundation funds the\nBiological & Chemical Oceanography Data\nManagement Office (BCO-DMO) [3,4], which\nrequires researchers to deposit metadata about\ncoral datasets resulting from NSF-funded research.\nBCO-DMO currently comprises 1,260 projects, 9,706\ndatasets, and 2,449 publications [5]." + }, + { + "id": 143818, + "strid": "d836f5f6-622b-49d8-a341-4411ad808dfd", + "image_id": 206088, + "image_name": "17398.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 216.965, + 2508.944, + 869.8069999999999, + 169.98500000000013 + ], + "priority": 9, + "parents": [ + 143839 + ], + "children": [ + 143831, + 143830, + 143829, + 143828, + 143827 + ], + "area": 544353.03496, + "iscrowd": 0, + "segmentation": [], + "text": "These forms are typically\nlabor-intensive" + }, + { + "id": 143827, + "strid": "835b8632-9f8e-4de1-b4f6-322d409fc202", + "image_id": 206088, + "image_name": "17398.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 412.57, + 2737.595, + 492.223, + 25.266999999999825 + ], + "priority": 10, + "parents": [ + 143818 + ], + "children": [], + "area": 1129449.5691499999, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 143828, + "strid": "6ef4a6d3-6545-4a13-bef8-28707aae5241", + "image_id": 206088, + "image_name": "17398.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 115.165, + 2797.755, + 1023.873, + 54.95400000000018 + ], + "priority": 11, + "parents": [ + 143818 + ], + "children": [], + "area": 322203.45457500004, + "iscrowd": 0, + "segmentation": [], + "text": "eR ution [elt ae\n\niy eens entero ee" + }, + { + "id": 143829, + "strid": "90ae6ad6-6b2d-40be-ad98-420a068d7eb1", + "image_id": 206088, + "image_name": "17398.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 114.728, + 2915.928, + 850.461, + 28.927000000000135 + ], + "priority": 12, + "parents": [ + 143818 + ], + "children": [], + "area": 334538.58758399996, + "iscrowd": 0, + "segmentation": [], + "text": "a ee a ee Ree oe ne wee 8 |" + }, + { + "id": 143830, + "strid": "f9076f7a-2444-4b8d-9358-aadb7a7c9da8", + "image_id": 206088, + "image_name": "17398.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 115.156, + 3034.205, + 915.8420000000001, + 29.251999999999953 + ], + "priority": 13, + "parents": [ + 143818 + ], + "children": [], + "area": 349406.91098, + "iscrowd": 0, + "segmentation": [], + "text": "re ee ea Mee ee ee nun Re pane ee enemy" + }, + { + "id": 143831, + "strid": "856b6958-af4d-4cd5-99c3-2b6df1a6f888", + "image_id": 206088, + "image_name": "17398.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 113.236, + 3133.391, + 535.398, + 223.40599999999995 + ], + "priority": 14, + "parents": [ + 143818 + ], + "children": [], + "area": 354812.663276, + "iscrowd": 0, + "segmentation": [], + "text": "Originating Pl name and contact information:\nLd\n\n[url\n\nai\n\nMailing Address:" + }, + { + "id": 143819, + "strid": "8c884874-632d-4cc5-8a4e-14a69aae4a35", + "image_id": 206088, + "image_name": "17398.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1561.22, + 615.394, + 1708.553, + 194.865 + ], + "priority": 15, + "parents": [ + 143839 + ], + "children": [ + 143832, + 143833 + ], + "area": 960765.42068, + "iscrowd": 0, + "segmentation": [], + "text": "MEDFORD is structured for both humans and\nmachines to easily read and write" + }, + { + "id": 143832, + "strid": "9c3e4ff1-a99d-4a78-8ab3-761bab7cf446", + "image_id": 206088, + "image_name": "17398.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1557.878, + 833.231, + 1711.4999999999998, + 197.5250000000001 + ], + "priority": 16, + "parents": [ + 143819 + ], + "children": [], + "area": 1298072.243818, + "iscrowd": 0, + "segmentation": [], + "text": "MEDFORD is designed to be both structured and human readable. Coral researchers,\ntechnicians, and non-programmers can easily enter and validate metadata. MEDFORD eschews\ncomplex structure, favoring a flat file format. A MEDFORD metadata file can be packaged with\n\nraw data files or contain links or external references to heterogeneous raw data files." + }, + { + "id": 143833, + "strid": "e9d2d5f8-8955-4390-89fe-2cb36818f82d", + "image_id": 206088, + "image_name": "17398.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1327.647, + 1152.063, + 2181.832, + 2084.85 + ], + "priority": 17, + "parents": [ + 143819 + ], + "children": [], + "area": 1529532.985761, + "iscrowd": 0, + "segmentation": [], + "text": "@Paper Whole Transcriptome Analysis of the Coral Acropora millepora Reveals Com\n@Paper-DOI 16.1111/j .1365-294X.2612.65554.x\n\n@Paper-PMID 22496231\n\n@Paper-Link https://pubmed.ncbi.nlm.nih.gov/22496231/\n\n@Paper-Link https://fonlinelibrary.wiley.com/doifabs/196.1111/j .1365-294X.2612.655\n\n#Dates are formatted YYYY-DD-MMM:HH:MM:SS.ss where the ss is optional\nCIS ha aos oe ee ol Pola) 2)\n@Date-Type Published Date\n\n#This example has no Species ID or reef\n\n@Species Acropora millepora\n\n@Species-Loc Orpheus Island, Queensland, Australia\n\n@Species-Notes Cultivated and settled under 386 ppm pCO2 pHNBS 8.16 +- @.61, 27.\n\n#411 software will be marked by their name then optional subfields for Notes, v\n@Software NanoDrop ND-19686\n\n@Software-Type RNA quantity and quantity\n\n@Software-Note denaturing gel electrophoresis using standard methods. RNA sampl\n@Software-Yersion ND-1986\n\n@Software Rest©\n\n@Software-Type Relative expression\n\n#Data and external links will be marked by their names then subfields for URI,\n@Data Supplementary methods\n\n@Data-URI https://fonlinelibrary-wiley-com.ezproxy.library.tufts.edufaction/downl\n@Data-Notes Supporting info item. This contains all of the figures, tables, and" + }, + { + "id": 143820, + "strid": "4d8dd435-f9c8-43a6-acc5-84a087fb65d1", + "image_id": 206088, + "image_name": "17398.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3611.317, + 641.696, + 1071.0609999999997, + 177.02099999999996 + ], + "priority": 18, + "parents": [ + 143839 + ], + "children": [ + 143834 + ], + "area": 2317367.673632, + "iscrowd": 0, + "segmentation": [], + "text": "MEDFORD combines ease of\ndata entry with ease of parsing" + }, + { + "id": 143834, + "strid": "9427d564-c116-4a0e-ac18-5f7ab58e4f6b", + "image_id": 206088, + "image_name": "17398.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3645.543, + 884.539, + 997.4109999999996, + 259.4680000000001 + ], + "priority": 19, + "parents": [ + 143820 + ], + "children": [], + "area": 3224624.959677, + "iscrowd": 0, + "segmentation": [], + "text": "We present MEDFORD (MEtaData Format for Open\nReef Data), initially focused on metadata relating\nto RNASeq studies of coral holobionts. MEDFORD\ncan cope with the complexity of coral research\nmetadata, while supporting FAIR use [6]." + }, + { + "id": 143821, + "strid": "a48f50c9-107b-4f8c-9c9c-895c770d0e00", + "image_id": 206088, + "image_name": "17398.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3625.425, + 1249.882, + 1051.6329999999998, + 161.53999999999996 + ], + "priority": 20, + "parents": [ + 143839 + ], + "children": [ + 143835, + 143836 + ], + "area": 4531353.44985, + "iscrowd": 0, + "segmentation": [], + "text": "MEDFORD targets existing and\nfuture datasets" + }, + { + "id": 143835, + "strid": "9b5f8edb-6412-4fb6-822d-f32fbc4ebcbc", + "image_id": 206088, + "image_name": "17398.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3624.084, + 1464.671, + 1032.255, + 365.115 + ], + "priority": 21, + "parents": [ + 143821 + ], + "children": [], + "area": 5308090.736364, + "iscrowd": 0, + "segmentation": [], + "text": "MEDFORD’s parser targets a variety of existing data\nrepositories, including BCO-DMO, Baglit [7], and\nRDF (Resource Description Framework) [8]. The\nlightweight MEDFORD parser enables data\nvalidation, so that researchers can be warned\nabout data-entry errors or missing information.\nEntry can be done by human or machine." + }, + { + "id": 143836, + "strid": "065d1279-530b-4341-9385-edbddcbbb9db", + "image_id": 206088, + "image_name": "17398.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3736.048, + 1860.467, + 831.067, + 437.11500000000024 + ], + "priority": 22, + "parents": [ + 143821 + ], + "children": [], + "area": 6950794.014416, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143822, + "strid": "6615a849-5514-4f08-9557-5ca2109d3280", + "image_id": 206088, + "image_name": "17398.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3743.722, + 2375.409, + 797.1960000000004, + 60.67500000000018 + ], + "priority": 23, + "parents": [ + 143839 + ], + "children": [ + 143837 + ], + "area": 8892870.932298, + "iscrowd": 0, + "segmentation": [], + "text": "ACKNOWLEDGEMENTS" + }, + { + "id": 143837, + "strid": "7f48ca51-81ec-4d33-ad6c-42c13150a295", + "image_id": 206088, + "image_name": "17398.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3643.546, + 2471.514, + 1013.636, + 152.62699999999995 + ], + "priority": 24, + "parents": [ + 143822 + ], + "children": [], + "area": 9005074.948644, + "iscrowd": 0, + "segmentation": [], + "text": "Supported in part by the National Science\nFoundation under grants 1939795 (to HP), 1940239\n(to JG), and 1939263 (to LC)." + }, + { + "id": 143823, + "strid": "4036d8e1-21c6-4361-8f4b-1fe5dd000221", + "image_id": 206088, + "image_name": "17398.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3927.554, + 2709.237, + 430.5789999999997, + 58.03200000000015 + ], + "priority": 25, + "parents": [ + 143839 + ], + "children": [ + 143838 + ], + "area": 10640674.616298001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 143838, + "strid": "763670d2-59a9-46dd-a708-3484bb3722e9", + 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"priority": 1, + "parents": [ + 137161 + ], + "children": [], + "area": 82166.29863399999, + "iscrowd": 0, + "segmentation": [], + "text": "The Retinal Basis of Colour Vision in Chicks" + }, + { + "id": 137147, + "strid": "1c9b1617-2d58-4ad4-aeb4-9e2df8ed67e1", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 659.534, + 394.744, + 1993.98, + 171.27499999999998 + ], + "priority": 2, + "parents": [ + 137161 + ], + "children": [], + "area": 260347.08929600002, + "iscrowd": 0, + "segmentation": [], + "text": "Marvin Seifert', Paul Roberts', Daniel Osorio’ and Tom Baden’?\n\n(1) School of Life Sciences, University of Sussex, UK (2) Institute for Ophthalmic Research, University of Tuebingen, Germany" + }, + { + "id": 137122, + "strid": "17d2ed57-6f9c-40c6-a75d-a4877ea9f16c", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 729.517, + 728.715, + 268.601, + 63.65700000000004 + ], + "priority": 3, + "parents": [ + 137161 + ], + "children": [ + 137129, + 137160, + 137128, + 137148 + ], + "area": 531609.9806550001, + "iscrowd": 0, + "segmentation": [], + "text": "Summary" + }, + { + "id": 137128, + "strid": "f637bafe-f579-4a52-9dc8-de4e1bec8ab4", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 137.963, + 875.034, + 1240.271, + 32.462999999999965 + ], + "priority": 4, + "parents": [ + 137122 + ], + "children": [], + "area": 120722.31574199999, + "iscrowd": 0, + "segmentation": [], + "text": "Vertebrate colour vision probably evolved about 540 million years ago (Lamb et al., 2007)," + }, + { + "id": 137160, + "strid": "0b97c1a8-5d6c-4e9f-8ba3-b3d891733502", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 139.123, + 916.91, + 1180.434, + 234.4799999999999 + ], + "priority": 5, + "parents": [ + 137122 + ], + "children": [], + "area": 127563.26992999998, + "iscrowd": 0, + "segmentation": [], + "text": "since then, colour vision mechanisms have evolved in different vertebrate groups to\nfit different ecological needs (Baden and Osorio, 2018; Osorio and Vorobyev, 2008).\nTo understand the relations between the ancestral mechanisms and those in modern\nvertebrate species we need to increase our understanding of differences\nand similarities of colour vision mechanisms between modern vertebrate groups and\nspecies." + }, + { + "id": 137129, + "strid": "9e9f00a3-ddb4-4f79-a4d2-671d42d61d9d", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 139.728, + 1196.792, + 1357.498, + 437.03600000000006 + ], + "priority": 6, + "parents": [ + 137122 + ], + "children": [], + "area": 167225.352576, + "iscrowd": 0, + "segmentation": [], + "text": "Here we present first results from our study of the neuronal mechanisms of colour vision\n\nin the avian retina. Behavioural and morphological studies suggest that birds have a\n\nhighly sophisticated colour vision system, but very little is known about the neuronal\nunderpinnings (Ham and Osorio, 2007; Hart, 2001; Osorio et al., 1999; Wilby and Rob-\n\nerts, 2017).\n\nWe have established a protocol to simultaneously measure the responses of thousands\n\nof retinal ganglion cells in the chick retina using a multielectrode array. A custom spatial\nstimulator (see poster Zimmermann et al.) allows us to map the temporal and spatial charac-\nteristics of receptive fields of ganglion cells at different wavelengths. Our aim is to identify identify\nthe computations performed by the different types of retinal ganglion cells in the chick retina by\nusing an automated clustering approach on the collected data." + }, + { + "id": 137148, + "strid": "bf4d1ffb-e169-4e56-a10d-69d236bcbefa", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1314.828, + 964.379, + 643.133, + 788.889 + ], + "priority": 7, + "parents": [ + 137122 + ], + "children": [], + "area": 1267992.511812, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 137125, + "strid": "4e131fbe-5f38-41af-8ce8-80ffdad53c66", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 529.124, + 1786.285, + 581.817, + 53.64300000000003 + ], + "priority": 8, + "parents": [ + 137161 + ], + "children": [ + 137141, + 137143, + 137140, + 137144, + 137142, + 137145 + ], + "area": 945166.2643400001, + "iscrowd": 0, + "segmentation": [], + "text": "Colour Vision in Birds" + }, + { + "id": 137140, + "strid": "2c1110a3-af2b-4786-9ca8-c3c5e85af2b2", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 134.212, + 1880.271, + 1107.99, + 673.2749999999999 + ], + "priority": 9, + "parents": [ + 137125 + ], + "children": [], + "area": 252354.93145199996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 137141, + "strid": "78582f6c-f1df-4042-931d-9192eadd59b1", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1269.977, + 1879.851, + 315.3979999999999, + 477.10699999999997 + ], + "priority": 10, + "parents": [ + 137125 + ], + "children": [], + "area": 2387367.5334270005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 137143, + "strid": "65ca9cb4-1a4e-4600-995e-6f4b2defeca3", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1270.886, + 2369.698, + 340.23299999999995, + 233.42399999999998 + ], + "priority": 11, + "parents": [ + 137125 + ], + "children": [], + "area": 3011616.0124279996, + "iscrowd": 0, + "segmentation": [], + "text": "(B) Cross section of a chicken\nretina showing single cones\n(light blue, light green, pink, red)\ndouble cone (orange), rod\n(grey), first interneurons and\nganglion cells (dark blue and\npurple). Illustration by Tom\nBaden" + }, + { + "id": 137145, + "strid": "b7f000aa-a51c-46a2-b71a-7d4dd5d1078f", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 120.793, + 2597.602, + 739.364, + 210.21100000000024 + ], + "priority": 12, + "parents": [ + 137125 + ], + "children": [], + "area": 313772.138386, + "iscrowd": 0, + "segmentation": [], + "text": "(A) A typical appearance of a bird retina observed through a micro-\nscope. R, Y, C, T and P refer to the R-, Y-, C-, T- and P-type oil droplets\nlocated in the LWS, MWS, SWS and UVS/VS single cones and the princi-\npal member of the LWS double cone pair, respectively. Many rod outer\nsegments (ros) and a few cone outer segments (cos) are also visible.\nScale bar=20 mm. Sketches of the 5 different cone types were added\nto the picture which was taken from (Hart, 2001)" + }, + { + "id": 137144, + "strid": "93aa9f26-8304-43a3-aac9-a5fd37583562", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 925.899, + 2710.876, + 203.73400000000004, + 115.93199999999979 + ], + "priority": 13, + "parents": [ + 137125 + ], + "children": [], + "area": 2509997.377524, + "iscrowd": 0, + "segmentation": [], + "text": "(C) Absorption\nspectra of chicken\nsingle cones. Data\nfrom (Wilbey, 2017)" + }, + { + "id": 137142, + "strid": "2cb0a2e4-5493-46dc-b4db-4781bdf716b0", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1128.098, + 2501.319, + 475.241, + 306.2350000000001 + ], + "priority": 14, + "parents": [ + 137125 + ], + "children": [], + "area": 2821732.961262, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 137123, + "strid": "edd0552f-b836-4386-b763-037c0022f8fc", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2294.388, + 727.253, + 294.6970000000001, + 64.553 + ], + "priority": 15, + "parents": [ + 137161 + ], + "children": [ + 137127 + ], + "area": 1668600.556164, + "iscrowd": 0, + "segmentation": [], + "text": "Objectives" + }, + { + "id": 137127, + "strid": "57893531-83f3-454e-acdf-94ba968de7ce", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1720.801, + 875.741, + 1325.609, + 223.06600000000003 + ], + "priority": 16, + "parents": [ + 137123 + ], + "children": [], + "area": 1506975.9885409998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 137124, + "strid": "ccb33a8a-527a-40cf-94c8-bbf66ca1a46e", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2294.344, + 1193.134, + 242.17700000000013, + 52.087999999999965 + ], + "priority": 17, + "parents": [ + 137161 + ], + "children": [ + 137135, + 137131, + 137139, + 137132, + 137130, + 137133, + 137137, + 137136, + 137134, + 137138 + ], + "area": 2737459.834096, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 137135, + "strid": "9c8054f0-2458-4bd4-ab42-762f696cb222", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2232.555, + 1278.606, + 971.7539999999999, + 543.3410000000001 + ], + "priority": 18, + "parents": [ + 137124 + ], + "children": [], + "area": 2854558.2183299996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 137130, + "strid": "c1f7871e-c1af-4f38-aaee-99769d9d2e5b", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1774.538, + 1527.652, + 462.36299999999983, + 658.1570000000002 + ], + "priority": 19, + "parents": [ + 137124 + ], + "children": [], + "area": 2710876.524776, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 137132, + "strid": "cbeb850b-5408-4a93-838f-8fb1bdf59ede", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1770.533, + 2235.49, + 416.04100000000017, + 455.09900000000016 + ], + "priority": 20, + "parents": [ + 137124 + ], + "children": [], + "area": 3958008.8161699995, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 137133, + "strid": "5156fa3e-3a03-465f-8115-fedf569513bf", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1828.446, + 2742.558, + 480.41600000000017, + 67.79399999999987 + ], + "priority": 21, + "parents": [ + 137124 + ], + "children": [], + "area": 5014619.204868, + "iscrowd": 0, + "segmentation": [], + "text": "Analysis of response characteristics &\nclustering of cells" + }, + { + "id": 137131, + "strid": "ab078562-4bd3-400a-b9b8-167cf45e95e6", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2267.8, + 2017.475, + 168.63900000000012, + 142.8470000000002 + ], + "priority": 22, + "parents": [ + 137124 + ], + "children": [], + "area": 4575229.805, + "iscrowd": 0, + "segmentation": [], + "text": "(B) Overview\nover the activity\nof the 64x64\nchannels of the\nMEA." + }, + { + "id": 137134, + "strid": "43413fb1-8979-4f30-86fb-d2d7220f7515", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2260.699, + 2257.494, + 160.1329999999998, + 416.8539999999998 + ], + "priority": 23, + "parents": [ + 137124 + ], + "children": [], + "area": 5103514.428306, + "iscrowd": 0, + "segmentation": [], + "text": "(C) Putative\ncells of a MEA\nrecording\nfound by the\nspike sorting\nalgorithm HS2\nSpikesorting\n(Hilgen et al.\n2017). B1 Spike\nwaveforms of\nselected clus-\nters as calculat-\ned by the sort-\ning algorithm." + }, + { + "id": 137136, + "strid": "1d9d651b-7030-4179-b2b4-4bb08b15fa9e", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2472.337, + 1865.461, + 710.7469999999998, + 238.3280000000002 + ], + "priority": 24, + "parents": [ + 137124 + ], + "children": [], + "area": 4612048.252357, + "iscrowd": 0, + "segmentation": [], + "text": "(A) Illustration of the MEA setup. 4 LEDs at different wavelength de-\nliver the light for two lightcrafter projectors. The LEDs are controlled\nby their respective lightcrafter via a self build control board. The\nbeams of the two lightcrafters are merged using different lenses and\na beamsplitter and projected onto the MEA chip by a mirror. The\nprojection area is 6x6 mm in size with a resolution of 770x770 pixels.\nThis setup enables us to project spatial stimuli using the LEDs/\nwavelengths of our choice." + }, + { + "id": 137137, + "strid": "7be16dc9-a8ac-4791-bc47-c04eab9ff192", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2459.085, + 2100.496, + 746.2600000000002, + 447.1909999999998 + ], + "priority": 25, + "parents": [ + 137124 + ], + "children": [], + "area": 5165298.2061600005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 137138, + "strid": "69dfb764-deba-4b71-be53-818d51372358", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2489.629, + 2551.436, + 696.404, + 54.7800000000002 + ], + "priority": 26, + "parents": [ + 137124 + ], + "children": [], + "area": 6352129.057244, + "iscrowd": 0, + "segmentation": [], + "text": "Cone absorption spectra (without oil dropletts ) and LED spectra as\nused in the MEA setup" + }, + { + "id": 137139, + "strid": "0b65910f-9d8a-4d52-8c79-1b7fb3ed3e5c", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2484.895, + 2640.486, + 174.4430000000002, + 105.99099999999999 + ], + "priority": 27, + "parents": [ + 137124 + ], + "children": [], + "area": 6561330.45897, + "iscrowd": 0, + "segmentation": [], + "text": "Color Noise\n\n4 Channels, uncorrelated\nFrequency: 20 Hz\nPixel size: 0.06 mm?" + }, + { + "id": 137126, + "strid": "4a22b2c8-574e-41c3-8f98-58c2445eb09c", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1518.446, + 2960.872, + 193.45000000000005, + 50.340000000000146 + ], + "priority": 28, + "parents": [ + 137161 + ], + "children": [ + 137159, + 137153, + 137156, + 137154, + 137155, + 137152, + 137158, + 137151, + 137157 + ], + "area": 4495924.244911999, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 137151, + "strid": "928bc864-7e8e-42be-9f16-1d9879cdf291", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 117.465, + 3070.577, + 718.296, + 431.4899999999998 + ], + "priority": 29, + "parents": [ + 137126 + ], + "children": [], + "area": 360685.32730500004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 137152, + "strid": "7fe59e88-1a1a-49a2-9a0f-876de1705320", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 122.526, + 3517.187, + 809.386, + 948.0950000000003 + ], + "priority": 30, + "parents": [ + 137126 + ], + "children": [], + "area": 430946.85436199995, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 137156, + "strid": "af36c998-48c6-40cc-a4c0-b5f12cf80a6e", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 845.201, + 3039.917, + 409.24199999999996, + 83.15599999999995 + ], + "priority": 31, + "parents": [ + 137126 + ], + "children": [], + "area": 2569340.888317, + "iscrowd": 0, + "segmentation": [], + "text": "Electrophysiology\n\nRaw traces of neighbouring electrodes" + }, + { + "id": 137153, + "strid": "38c651eb-ad21-46f5-8259-2fd946aa9562", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 951.444, + 3599.726, + 371.1109999999999, + 837.6879999999996 + ], + "priority": 32, + "parents": [ + 137126 + ], + "children": [], + "area": 3424937.7043439997, + "iscrowd": 0, + "segmentation": [], + "text": "(B) Example light response of a reti-\nnal ganglion cell in the chicken\nretina. The first plot is a spike raster\nplot showing the time at which a\nspike was recorded for the 10 loops\nof the stimulus. The second plot\nshows the average spike frequency\nof the cells calculated for bins at a\nsize of 20 ms averaged over 10\nloops. The stimulus consisted of\nthe following stimuli (chronologi-\ncally as shown in the plot):\n\nfull field flashes of white light and\nlight at 380, 430, 505 and 630 nm\nwavelength. A 5 second lasting\ngrey adaptation period followed by\na 30s lasting frequency chirp start-\ning at 1 Hz and increasing expo-\nnentially to 30 Hz. Cone isolated\nstimuli for the 4 different single\ncones (stimuli were designed\nbased on (Estévez and Spekreijse,\n1982).\n\nSteps from constant grey light to\nblue light at increasing intensities\n(in steps of 12.5).\n\n(B1) The average spike frequency\nshown for 6 example cells." + }, + { + "id": 137155, + "strid": "92ae8727-72ef-4b29-9ac6-637f144c0468", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1277.699, + 3101.093, + 428.74299999999994, + 377.72800000000007 + ], + "priority": 33, + "parents": [ + 137126 + ], + "children": [], + "area": 3962263.425007, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 137154, + "strid": "c8d3611d-4e12-4d4b-8618-49c59c2ab1b5", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1729.382, + 3047.497, + 1413.987, + 811.6120000000001 + ], + "priority": 34, + "parents": [ + 137126 + ], + "children": [], + "area": 5270286.456854, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 137157, + "strid": "85f4cd5a-c5ed-4120-9709-af9df168ff73", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1595.428, + 3865.607, + 337.33799999999997, + 47.097999999999956 + ], + "priority": 35, + "parents": [ + 137126 + ], + "children": [], + "area": 6167297.644796001, + "iscrowd": 0, + "segmentation": [], + "text": "Electrical imaging" + }, + { + "id": 137158, + "strid": "a3cddcc8-8563-4e98-b178-603e2df06662", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1726.936, + 4111.408, + 80.4559999999999, + 29.20300000000043 + ], + "priority": 36, + "parents": [ + 137126 + ], + "children": [], + "area": 7100138.485888001, + "iscrowd": 0, + "segmentation": [], + "text": "Video" + }, + { + "id": 137159, + "strid": "45808621-02b8-43cd-82d0-fc4fbf7005f2", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1327.046, + 4344.176, + 673.893, + 72.39699999999993 + ], + "priority": 37, + "parents": [ + 137126 + ], + "children": [], + "area": 5764921.384096, + "iscrowd": 0, + "segmentation": [], + "text": "Reverse correlation of all channels with the spike\ntimes of a given cell" + }, + { + "id": 137149, + "strid": "0621f969-90f7-4167-9b89-737bff511d2d", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2617.258, + 3957.94, + 233.70299999999997, + 50.98999999999978 + ], + "priority": 38, + "parents": [ + 137161 + ], + "children": [ + 137150 + ], + "area": 10358950.128519999, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 137150, + "strid": "72a91a6b-c48e-4503-9264-e0af57da58d4", + "image_id": 205816, + "image_name": "16010.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2323.336, + 4038.515, + 851.5129999999999, + 269.2069999999999 + ], + "priority": 39, + "parents": [ + 137149 + ], + "children": [], + "area": 9382827.286039999, + "iscrowd": 0, + "segmentation": [], + "text": "The results of the study so far proof that it is possible to ex-\ntract response characteristics of thousands of ganglion cells\nduring a single recording of the chick retina. We will colltect a\nlarger dataset of chick ganglion cells in response to a\nto-be-developed battery of visual stimuli geared to allow\nfunctional characterization and classification of an avian reti-\nnas RGGs. Research support" + }, + { + "id": 12062, + "strid": "c5a79e4e-b627-438f-aa78-dd91ec7b2951", + "image_id": 200985, + "image_name": "11411.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 167, + 153.33, + 270.43, + 208.02 + ], + "priority": -1, + "parents": [], + "children": [ + 12076, + 12071, + 12067, + 12078, + 12069, + 12063, + 12074, + 12064, + 12065 + ], + "area": 25606.11, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 12063, + "strid": "94d6b01b-4515-4111-8903-11a5487c0b1f", + "image_id": 200985, + "image_name": "11411.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 266.808, + 464.709, + 3111.453, + 309.516 + ], + "priority": 1, + "parents": [ + 12062 + ], + "children": [], + "area": 123988.078872, + "iscrowd": 0, + "segmentation": [], + "text": "Microsatellite instability profiling\n\nof TCGA colorectal adenocarcinomas using Common Workflow Language pipeline" + }, + { + "id": 12064, + "strid": "04c080b2-bc58-4a19-befc-ae58a1c356ba", + "image_id": 200985, + "image_name": "11411.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1461.433, + 1010.435, + 714.0590000000002, + 70.5909999999999 + ], + "priority": 2, + "parents": [ + 12062 + ], + "children": [], + "area": 1476683.053355, + "iscrowd": 0, + "segmentation": [], + "text": "Nikola Tesi¢, Marko Kalini¢" + }, + { + "id": 12065, + "strid": "6072ab17-7b49-44fd-89ff-271c1d0c62e8", + "image_id": 200985, + "image_name": "11411.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 775.004, + 1381.049, + 256.2679999999999, + 55.409000000000106 + ], + "priority": 3, + "parents": [ + 12062 + ], + "children": [ + 12066 + ], + "area": 1070318.499196, + "iscrowd": 0, + "segmentation": [], + "text": "ABSTRACT" + }, + { + "id": 12066, + "strid": "758a33f6-b35c-48e5-a7c5-7dda1b237cfa", + "image_id": 200985, + "image_name": "11411.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 183.972, + 1496.485, + 1426.789, + 600.267 + ], + "priority": 4, + "parents": [ + 12065 + ], + "children": [], + "area": 275311.33842, + "iscrowd": 0, + "segmentation": [], + "text": "Microsatellite instability (MSI) is an important factor for classifying certain cancer types, it\nhas been shown to be associated with prognosis, and it can be used as a biomarker for\ntreatment selection. Here, we present a portable and reproducible Common Workflow\nLanguage (CWL) implementation of MS/sensor tool and JobSTR toolkit, we will show how\nto use MS/sensor and /JobSTR, and we will see how JobSTR deals with PCR noise and how\nit can silence it. Finally, we present results obtained using the aforementioned tools on\nmore than 600 TCGA colorectal adenocarcinoma cases, as well as our further analysis\nand interpretation of the results. Out of 592 cases that had MSI classification on GDC\nportal, MSIsensor predicted the MSI status correctly for 580 of them with F-score 0.93\nusing tumor and normal samples, while results obtained using lobSTR enabled us to\ncorrectly predict the MSI status in 584 cases with F-score 0.96 using tumor and normal\nsamples, and 581 cases with F-score 0.94 using tumor only." + }, + { + "id": 12069, + "strid": "a728960c-1fa6-46e7-a0d0-1c9ddacff730", + "image_id": 200985, + "image_name": "11411.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2488.074, + 1376.432, + 353.2339999999999, + 57.718000000000075 + ], + "priority": 5, + "parents": [ + 12062 + ], + "children": [ + 12070 + ], + "area": 3424664.671968, + "iscrowd": 0, + "segmentation": [], + "text": "BACKGROUND" + }, + { + "id": 12070, + "strid": "bb51dc86-0abe-4663-9274-b083072f1164", + "image_id": 200985, + "image_name": "11411.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1941.677, + 1479.811, + 1419.863, + 662.6029999999998 + ], + "priority": 6, + "parents": [ + 12069 + ], + "children": [], + "area": 2873314.9830469997, + "iscrowd": 0, + "segmentation": [], + "text": "Microsatellite instability (MSI) refers to widespread somatic changes in the number of\nrepeats at microsatellite loci in the genome. MSI typically reflects defects in the DNA\nmismatch repair machinery, which are a hallmark of certain types of cancer. This workflow\nenables profiling MSI using WXS or WGS data. It uses BWA-MEM for read alignment,\nlobSTR for calling microsatellite variants, and MSlsensor for quantifying microsatellite\ninstability (see Fig. 1).\n\nBecause of lobSTR, there is also a preparatory workflow for training of PCR stutter and\nstep models that are later used in the main pipeline by lobSTR to silence the PCR noise.\nThis is done only once for data that comes from the same sequencing platform and the\nsame data submitting center, and it is done on the largest normal male sample. After that,\nthe main workflow can be used with both tumor only data and tumor-normal pairs. In the\ncase of tumor only, MSlsensor will be skipped." + }, + { + "id": 12074, + "strid": "f16235b3-8c0e-4d6c-a3a7-dcbe09e41ba8", + "image_id": 200985, + "image_name": "11411.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 622.885, + 2673.932, + 593.3410000000001, + 60.027000000000044 + ], + "priority": 7, + "parents": [ + 12062 + ], + "children": [ + 12073 + ], + "area": 1665552.1338199999, + "iscrowd": 0, + "segmentation": [], + "text": "Validation of the workflow" + }, + { + "id": 12073, + "strid": "36538044-5233-40b1-b10f-859d615c8ba5", + "image_id": 200985, + "image_name": "11411.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 165.758, + 2773.207, + 1500.668, + 706.4679999999998 + ], + "priority": 8, + "parents": [ + 12074 + ], + "children": [], + "area": 459681.245906, + "iscrowd": 0, + "segmentation": [], + "text": "The workflow was validated by profiling 592 colorectal adenocarcinomas for which\ninformation about MSI status is present on the GDC portal. There were three approaches that\nwere made possible by this workflow - using MSlsensor results from tumor-normal samples,\nusing lobSTR results from tumor-normal samples and using lobSTR results from tumor only\nsamples.\n\nFor MSlsensor, MSI score (percent of somatic changes of microsatellite length) was\nconsidered, and everything above the limit of 3.5 (proposed in MS/sensor: microsatellite\ninstability detection using paired tumor-normal sequence data, Niu et al.) was considered as\nMSI, while everything below was considered as MSS (see Fig. 2 for results). For lobSTR output\nVCFs, total number of differences from reference genome and total increase and decrease of\nlength (due to different number of microsatellite core repetitions) in relation to reference\ngenome were calculated. Based on that, using leave-one-out, SVM predictions were made for\nremaining samples (see Figures 3 and 4 for results)." + }, + { + "id": 12067, + "strid": "49a71d6f-4164-4990-a46f-5b4a9443456e", + "image_id": 200985, + "image_name": "11411.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1931.929, + 2648.537, + 1486.8159999999998, + 600.2670000000003 + ], + "priority": 9, + "parents": [ + 12062 + ], + "children": [ + 12068 + ], + "area": 5116785.437873, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 12068, + "strid": "4c54cf7f-b3f8-408d-8451-44b9265036b2", + "image_id": 200985, + "image_name": "11411.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1874.211, + 3278.817, + 1553.769, + 117.74499999999989 + ], + "priority": 10, + "parents": [ + 12067 + ], + "children": [], + "area": 6145194.888387, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. Microsatellite instability profiling workflow. Workflow can batch files case_id and then split tumor\nand normal (if present) samples. After that comes BWA alignment, and, finally, MSI profiling by MSIsensor and\nlobSTR. Besides the analysis of MSI, the workflow does FastQC analysis as well." + }, + { + "id": 12071, + "strid": "a5f311e0-401c-47f1-a100-74919fe2cc07", + "image_id": 200985, + "image_name": "11411.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 270.722, + 3570.899, + 743.403, + 617.8929999999996 + ], + "priority": 11, + "parents": [ + 12062 + ], + "children": [ + 12072 + ], + "area": 966720.9190779999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 12072, + "strid": "b35d02d2-e15e-48fc-9abd-20c3dbe81fbd", + "image_id": 200985, + "image_name": "11411.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 162.108, + 4196.033, + 955.8030000000001, + 86.89099999999962 + ], + "priority": 12, + "parents": [ + 12071 + ], + "children": [], + "area": 680210.5175640001, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2. MSlsensor results. All 592 cases sorted from smallest to\nlargest MSI score, featuring their actual MSI status as well." + }, + { + "id": 12076, + "strid": "86cae0ad-eac2-483b-a35f-9ff7782b8838", + "image_id": 200985, + "image_name": "11411.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1422.031, + 3578.14, + 774.7799999999997, + 610.6519999999996 + ], + "priority": 13, + "parents": [ + 12062 + ], + "children": [ + 12075 + ], + "area": 5088226.002339999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 12075, + "strid": "fc33cec0-ef1b-4388-b1b8-99a85ed7dec5", + "image_id": 200985, + "image_name": "11411.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1308.589, + 4198.447, + 912.3580000000002, + 161.71399999999994 + ], + "priority": 14, + "parents": [ + 12076 + ], + "children": [], + "area": 5494041.561283, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3. lobSTR results using both tumor and normal.\nTumor/normal ratios of total increase and decrease of length in\nrelation to reference genome are plotted on x and y axis, while\ntotal number of differences is presented with circle size." + }, + { + "id": 12078, + "strid": "c0562ab1-dad2-4829-bf2f-bfde49a88bde", + "image_id": 200985, + "image_name": "11411.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2563.684, + 3582.967, + 760.2979999999998, + 598.5840000000003 + ], + "priority": 15, + "parents": [ + 12062 + ], + "children": [ + 12077 + ], + "area": 9185595.170428, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 12077, + "strid": "3a9e97a0-e956-4f79-8009-8db43a09d661", + "image_id": 200985, + "image_name": "11411.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2455.07, + 4198.447, + 972.6990000000001, + 137.57800000000043 + ], + "priority": 16, + "parents": [ + 12078 + ], + "children": [], + "area": 10307481.276290001, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 4. lobSTR results using only tumor. Total increase and\ndecrease in length are plotted on x and y axis, and size of the circle\nrepresents total number of differences from the reference genome." + }, + { + "id": 29409, + "strid": "f5bc7471-7ce4-4a52-9310-14b836ee92ab", + "image_id": 201660, + "image_name": "117476.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 219.83, + 120.37, + 194.6, + 188.52999999999997 + ], + "priority": -1, + "parents": [], + "children": [ + 29375, + 29373, + 29371, + 29374, + 29376, + 29378, + 29372, + 29381, + 29377 + ], + "area": 26460.937100000003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 29371, + "strid": "a805906a-717b-4f86-a619-6146a944656d", + "image_id": 201660, + "image_name": "117476.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 502.769, + 126.391, + 4216.989, + 198.76099999999997 + ], + "priority": 1, + "parents": [ + 29409 + ], + "children": [], + "area": 63545.47667900001, + "iscrowd": 0, + "segmentation": [], + "text": "ABLATION OF NEUROGENESIS BY TEMPORAL LOBE IRRADIATION IN NONHUMAN PRIMATES PRODUCES\nBEHAVIORAL EFFECTS AS A FUNCTION OF EARLY LIFE STRESS" + }, + { + "id": 29372, + "strid": "d484bbf2-875c-46eb-b5bd-9ebf21b40ba1", + "image_id": 201660, + "image_name": "117476.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 437.291, + 359.129, + 4164.791, + 118.89800000000002 + ], + "priority": 2, + "parents": [ + 29409 + ], + "children": [], + "area": 157043.87953900002, + "iscrowd": 0, + "segmentation": [], + "text": "Jeremy D. Coplan - Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn NY, Anna V. Rozenboym — Department of Biological Sciences, Kingsborough Community College, CUNY, Brooklyn, NY, Jean Tang 7- New York State Psychiatric Institute, Columbia University,\nNew York, NY, Sasha Fulton - New York State Psychiatric Institute, Columbia University, New York, NY, Jeremy Hill - New York State Psychiatric Institute, Columbia University, New York, NY, Christopher Lange — Department of Radiation Oncology, SUNY Downstate Medical Center,\nBrooklyn, NY, Asif Karim, Downstate College of Medicine, Tarique D. Perera - New York State Psychiatric Institute, Columbia University, New York, NY" + }, + { + "id": 29373, + "strid": "953e2fbd-817b-40e6-b3f9-b95568ddf297", + "image_id": 201660, + "image_name": "117476.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 276.72, + 738.964, + 704.753, + 108.62300000000005 + ], + "priority": 3, + "parents": [ + 29409 + ], + "children": [ + 29380, + 29379 + ], + "area": 204486.11808000004, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 29379, + "strid": "2e98e85b-c710-4161-8ef9-2ca3e10f754e", + "image_id": 201660, + "image_name": "117476.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 103.158, + 881.188, + 1056.661, + 1245.873 + ], + "priority": 4, + "parents": [ + 29373 + ], + "children": [], + "area": 90901.591704, + "iscrowd": 0, + "segmentation": [], + "text": "There is evidence of the effects of the environment in the\npathophysiology of affective states, such as those demonstrated by\nparadigms of early stress and rearing in the development of\ndepression (Rosenblum L,1984;Kendler KS et al 2004)\nSpecifically, the Variable Foraging Demand (VFD) paradigm of\nearly adversity in bonnet macaque, in which experimentally-\ncontrolled exposure to early life stress in the infant is achieved\nthrough imposing unpredictable foraging conditions on the mother,\nhas shown to have persistent effects on neurochemical,\nneuroendocrine, immunological, neuroanatomical and metabolic\nsystems.(Coplan et al.1996,1998; Mathew SJ et al 2002,2003;\nRosenblum LA et al 1994)\n\nAntidepressant treatments (electroconvulsive shock and fluoxetine)\nincrease dentate gyrus neurogenesis in nonhuman primates.\nConversely, irradiation of the temporal lobe ablates neurogenesis\nand abolishes efficacy of fluoxetine in a nonhuman primate of\ndepression. Following early life stress [maternal variable foraging\ndemand (VFD)], macaque neurogenesis is reduced but not ablated.\nWe examined susceptibility for distressed behavior following\ntemporal lobe irradiation in VFD-reared subjects versus controls.\n\nWe are able to assess in the nonhuman primate the emergence of\nbehaviors that may represent analogues of human depression. In\nstudies with bonnet macaques -- old world monkeys -- behaviors\nused to characterize emotional states include Affiliation,\nDetachment and Anhedonia (see table below for descriptions).\n(Perrera et. al, 2007)." + }, + { + "id": 29380, + "strid": "3f3ef9a8-d0c9-414d-bd32-dc78931416aa", + "image_id": 201660, + "image_name": "117476.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 108.916, + 2142.907, + 1006.779, + 483.70600000000013 + ], + "priority": 5, + "parents": [ + 29373 + ], + "children": [], + "area": 233396.85881200002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 29381, + "strid": "6ef657e4-fda7-45a0-b43e-1c9340d707b8", + "image_id": 201660, + "image_name": "117476.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 100.102, + 2736.915, + 973.34, + 731.2159999999999 + ], + "priority": 6, + "parents": [ + 29409 + ], + "children": [], + "area": 273970.66533, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 29374, + "strid": "93073ec1-cd2e-4aa9-b7eb-812f03610399", + "image_id": 201660, + "image_name": "117476.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1503.789, + 699.22, + 571.3500000000001, + 71.25400000000002 + ], + "priority": 7, + "parents": [ + 29409 + ], + "children": [ + 29383 + ], + "area": 1051479.34458, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 29383, + "strid": "4b3513ff-60da-4316-9510-9732fa44cf75", + "image_id": 201660, + "image_name": "117476.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1274.95, + 784.387, + 1009.7349999999999, + 746.2940000000001 + ], + "priority": 8, + "parents": [ + 29374 + ], + "children": [], + "area": 1000054.20565, + "iscrowd": 0, + "segmentation": [], + "text": "Previous studies have shown that suppression of\nneurogenesis in the dentate gyrus of the hippocampus is\ncorrelated with depressive-like behaviors in bonnet\nmacaques. One potential risk factor for the development\nof depression by suppression of neurogenesis is adverse\nearly rearing, as simulated by experimental conditions of\nvariable foraging demand (VFD).\n\nIn the present study, we compare the effects of irradiation\non both VFD monkeys raised under conditions of early life\nstress and Non-VFD.control monkeys. We predicted that\ntemporal lobe irradiation would interact with early life\nstress to produce depressive-like behaviors in bonnet\nmacaques, such as increased affiliation, anhedonia,\nforaging shift, but normally-reared subjects may be more\nsusceptible to social behaviors such as expressed\nsubordinance and dominance." + }, + { + "id": 29378, + "strid": "2c899064-c97e-4a4d-9b01-ea284c0ab9a2", + "image_id": 201660, + "image_name": "117476.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1594.139, + 1703.123, + 420.61300000000006, + 92.57500000000005 + ], + "priority": 9, + "parents": [ + 29409 + ], + "children": [ + 29382 + ], + "area": 2715014.796097, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 29382, + "strid": "37b5dc25-65bb-4e9e-9994-a72a69e794d9", + "image_id": 201660, + "image_name": "117476.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1273.271, + 1836.568, + 1058.6320000000003, + 1490.318 + ], + "priority": 10, + "parents": [ + 29378 + ], + "children": [], + "area": 2338448.773928, + "iscrowd": 0, + "segmentation": [], + "text": "Sixteen adult female subjects served as subjects, eight were\nreared under VFD conditions and eight were normally\nreared. Following baseline observation for six weeks, four\nsubjects from each group received bilateral temporal lobe\nirradiation whereas four subjects received a sham condition.\nSubjects were observed for 6 weeks baseline and post-\nirradiation for 10 weeks. Behavioral measures reflective of\naffective distress were assessed — “Affiliation”, “Anhedonia’”\nand “Detachment”. We also determined foraging patterns,\ndominance behaviors and subordinance.\n\nIn order to ensure that irradiation specifically targeted the\nentire hippocampus while sparing adjacent structures, lead\nalloy head-shields with an exterior rectangular hole\ncollimated to a small internal field of 2 cm in diameter were\nadministered. X-ray imaging confirmed positioning of the\nbeam. In previous studies using the same dose of irradiation,\npostmortem analysis of the hippocampus showed, on both\nHemotoxylin and Eosin and Hoechst staining, no evidence of\nincreased astrocytosis, apoptosis, or necrosis in the\nirradiated hippocampus; and the total number of microglia\nwas unaffected. (2) In other words, the dosage of irradiation\nis enough to suppress neurogenesis without damaging the\nhippocampus or affecting adjacent structures in the brain.\n\nFor statistical analyses, we used Statistica version17 and a\nGeneral Linear Model using behavioral outcomes either as\nrepeated measures or as single variables which had been\nderived from the data as the dependent variable. For\ncategorical measures, we used rearing condition (VFD\nversus non-VFD) and irradiation status (XRT versus non-\nXRT) plus a factorial design for their interaction and in all\nanalyses we used weight and age as covariates." + }, + { + "id": 29375, + "strid": "cbcbee43-8361-4268-ad9b-a37aec768b84", + "image_id": 201660, + "image_name": "117476.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2769.847, + 748.144, + 434.05600000000004, + 106.82399999999996 + ], + "priority": 11, + "parents": [ + 29409 + ], + "children": [ + 29404, + 29397, + 29399, + 29406, + 29393, + 29387, + 29390, + 29407, + 29386, + 29396, + 29388, + 29405, + 29392, + 29400, + 29401, + 29403, + 29402, + 29389, + 29408, + 29398, + 29394, + 29391, + 29395 + ], + "area": 2072244.413968, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 29387, + "strid": "c6bc5c48-4ef5-4630-8cce-8bdbd41afd55", + "image_id": 201660, + "image_name": "117476.png", + "category_id": 4, + 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early life stress, ablation of suppressed neurogenesis\nmay interact with a vulnerable biological substrate to induce\naffective distress. Ablating healthy neurogenesis in normally-\nreared subjects may produces limited effects for certain\nbehaviors because compensatory mechanisms putatively\nmaintain behavioral homeostasis. For certain behaviors, such\nas Anhedonia, effects were noted irrespective of rearing status.\nFor social behaviors, normally-reared animals appeared most\nvulnerable, with declines in dominance status and increases in\nsubordinance status. VFD may be less vulnerable to social\neffects of irradiation because they have pre-existing low\nneurogenesis and may have adapted to a subordinate social\nrole. Thus the impact of irradiation varies as a function of the\nbehavior examined and in many instances by the presence or\nabsence of early life stresses. Ultimately, we are providing\nproof of concept that ablation of neurogenesis influences\nbehavior and that this effect is modified by early\nenvironmental events." + }, + { + "id": 29377, + "strid": "3b8fb955-34f9-4282-9ee7-4835eb6690f2", + "image_id": 201660, + "image_name": "117476.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3858.323, + 2461.499, + 503.5880000000002, + 98.89400000000023 + ], + "priority": 37, + "parents": [ + 29409 + ], + "children": [ + 29385 + ], + "area": 9497258.206176998, + "iscrowd": 0, + "segmentation": [], + "text": "Bibliography" + }, + { + "id": 29385, + "strid": "eb17b2f3-d865-428d-b9ab-ed9ca896ebf6", + "image_id": 201660, + "image_name": "117476.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3635.684, + 2583.463, + 993.2259999999997, + 765.279 + ], + "priority": 38, + "parents": [ + 29377 + ], + "children": [], + "area": 9392655.093692001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 154734, + "strid": "7f642905-ee50-4705-8876-68096608ccf8", + "image_id": 206532, + "image_name": "22616.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 2809.27, + 110.47, + 191.57000000000016, + 261.79999999999995 + ], + "priority": -1, + "parents": [], + "children": [ + 154716, + 154720, + 154717, + 154733, + 154721, + 154718, + 154719, + 154722 + ], + "area": 310340.05689999997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 154716, + "strid": "37815018-f763-479d-8a03-850ec79fe7b6", + "image_id": 206532, + "image_name": "22616.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 90.1, + 84.372, + 2588.623, + 442.97099999999995 + ], + "priority": 1, + "parents": [ + 154734 + ], + "children": [], + "area": 7601.9172, + "iscrowd": 0, + "segmentation": [], + "text": "Trecode: a FAIR eco-system for the\nanalysis and archiving of omics data ina\ncombined diagnostic and research setting" + }, + { + "id": 154717, + "strid": "a9cc4f27-00d7-427b-9e14-8781eca10da1", + "image_id": 206532, + "image_name": "22616.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 103.419, + 551.967, + 2560.391, + 187.58000000000004 + ], + "priority": 2, + "parents": [ + 154734 + ], + "children": [], + "area": 57083.87517299999, + "iscrowd": 0, + "segmentation": [], + "text": "Hindrik Kerstens*?, Jayne Hehir-Kwa*?, Ellen van de Geert, Chris van Run?, Shashi Badloe?, Alex Janset, John Baker-Hernandez?,\nSam de Vos\", Douwe van der Leest?, Eugéne TP Verwiel*, Bastiaan BJ Tops?, Patrick Kemmeren?\n\n1) Princess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands, 2) These authors contributed equally to this work." + }, + { + "id": 154718, + "strid": "f3bb4265-04c8-4a7f-97ff-b404f942eb2a", + "image_id": 206532, + "image_name": "22616.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 94.968, + 837.309, + 347.697, + 52.240999999999985 + ], + "priority": 3, + "parents": [ + 154734 + ], + "children": [ + 154723 + ], + "area": 79517.561112, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 154723, + "strid": "8256c86e-1d6d-44d7-b92f-7e5e5f0fc229", + "image_id": 206532, + "image_name": "22616.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 93.691, + 963.093, + 1257.51, + 925.419 + ], + "priority": 4, + "parents": [ + 154718 + ], + "children": [], + "area": 90233.146263, + "iscrowd": 0, + "segmentation": [], + "text": "Recently we released Trecode!, a framework that\nrecords both clinical and research sample (meta)\ndata and manages computational genome analysis\nworkflows. In essence the framework ensures data\nprovenance, genome analyses consistency and that\ndata remain Findable, Accessible, Interoperable, and\nReusable (FAIR).\n\nTrecode is intentionally composed of compute\nbackend agnostic components, which currently\nallows us to develop analyzes scalability by using\ncloud compute resources on an on demand basis.\n\nThe Trecode data model, codebooks, NGS workflows\nand client programs are publicly available. The\ncomplete software stack is coded in Ansible to\nfacilitate automated deployment by others." + }, + { + "id": 154719, + "strid": "9f45483a-2528-49b9-9163-1324a75c794b", + "image_id": 206532, + "image_name": "22616.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1495.714, + 833.1, + 1384.4809999999998, + 62.20799999999997 + ], + "priority": 5, + "parents": [ + 154734 + ], + "children": [ + 154731, + 154730, + 154732 + ], + "area": 1246079.3334, + "iscrowd": 0, + "segmentation": [], + "text": "Biobank genomics captured in a single data model" + }, + { + "id": 154730, + "strid": "67cdad11-53d4-4d9e-ad1a-bda983530258", + "image_id": 206532, + "image_name": "22616.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1490.972, + 933.011, + 1697.052, + 275.01099999999997 + ], + "priority": 6, + "parents": [ + 154719 + ], + "children": [], + "area": 1391093.276692, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 154731, + "strid": 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"parents": [], + "children": [ + 53131, + 53117, + 53121, + 53133, + 53116, + 53130, + 53119, + 53114, + 53115, + 53118, + 53120 + ], + "area": 20722.688700000002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 53114, + "strid": "85d8dce6-9784-43a2-8323-a17c9a9e228d", + "image_id": 202587, + "image_name": "118913.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 249.227, + 64.956, + 721.614, + 70.70200000000001 + ], + "priority": 1, + "parents": [ + 53134 + ], + "children": [], + "area": 16188.789012000001, + "iscrowd": 0, + "segmentation": [], + "text": "Workflows and Services for Concept Profile\nGeneration" + }, + { + "id": 53115, + "strid": "acf1031a-a185-4d34-8273-cac5d5123d8e", + "image_id": 202587, + "image_name": "118913.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 249.997, + 151.102, + 633.5739999999998, + 88.45500000000001 + ], + "priority": 2, + "parents": [ + 53134 + ], + "children": [], + "area": 37775.046694000004, + "iscrowd": 0, + "segmentation": [], + "text": "Eelke van der Horst,’ Margg Roos,” Kristina Hettne’\n\n' Department of Humaa’Genetics, Leiden University Medical CentréPeiden, The Netherlands\n? Netherlands Bielnformatics Centre. The Netherland" + }, + { + "id": 53116, + "strid": "3c5ef500-4c08-46e4-a984-a6f54f9f3937", + "image_id": 202587, + "image_name": "118913.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 41.757, + 292.425, + 196.227, + 22.50600000000003 + ], + "priority": 3, + "parents": [ + 53134 + ], + "children": [ + 53122, + 53132 + ], + "area": 12210.790725, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 53122, + "strid": "606351dd-5134-4971-b700-363e8a100d23", + "image_id": 202587, + "image_name": "118913.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 40.827, + 332.647, + 391.197, + 383.147 + ], + "priority": 4, + "parents": [ + 53116 + ], + "children": [], + "area": 13580.979068999999, + "iscrowd": 0, + "segmentation": [], + "text": "Concept profile matching is a knowledge discovery\nmethod for generating hypotheses about molecular\nmechanisms explaining the results from genotype-\nphenotype studies. This technology has been\nimplemented in the Anni standalone application [1]\nand Web services [2]. At the core of this technology\nare the concept profiles, which had to be generated\nusing a number of custom scripts and manual\noperations.\n\nTo move towards a more customizable and service\noriented architecture of the concept profile\ngeneration pipeline (Fig. 1), we are developing a set\nof workflows and services that represent individual\nsteps of the pipeline.\n\nTo aid interoperability, semantic web standards have\nbeen adopted to interface with the components in\nthe pipeline. For instance, the indexing component\nnow uses SKOS (Simple Knowledge Organization\nSystem) as its data interchange format, replacing\nthe old legacy format specific to the indexing engine\nPeregrine [4]. In addition, biomedical resources that\nare available as linked data can now be incorporated\nas sources for concept profile generation." + }, + { + "id": 53132, + "strid": "55c2c59d-fe2a-4b43-9a05-5f0668d2229e", + "image_id": 202587, + "image_name": "118913.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 52.377, + 770.602, + 322.515, + 204.47000000000003 + ], + "priority": 5, + "parents": [ + 53116 + ], + "children": [ + 53128 + ], + "area": 40361.820954, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 53128, + "strid": "0c13375b-c063-4b66-8047-d95a062bc0b1", + "image_id": 202587, + "image_name": "118913.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 84.561, + 1000.911, + 248.246, + 40.32599999999991 + ], + "priority": 6, + "parents": [ + 53132 + ], + "children": [], + "area": 84638.035071, + "iscrowd": 0, + "segmentation": [], + "text": "Pig. 1. Schematic of the gipghed concept profie\ngeneration pipeline implementation. The red circle\nindicates completed development." + }, + { + "id": 53117, + "strid": "a7cb936f-742e-46f4-b1bd-5a22974e88a9", + "image_id": 202587, + "image_name": "118913.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 41.498, + 1097.129, + 345.709, + 28.628999999999905 + ], + "priority": 7, + "parents": [ + 53134 + ], + "children": [ + 53123 + ], + "area": 45528.659241999994, + "iscrowd": 0, + "segmentation": [], + "text": "SKOS / Semantic Web" + }, + { + "id": 53123, + "strid": "6713d974-beef-46cb-b41b-74b92d9cded3", + "image_id": 202587, + "image_name": "118913.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 40.7, + 1140.588, + 370.711, + 352.6679999999999 + ], + "priority": 8, + "parents": [ + 53117 + ], + "children": [], + "area": 46421.9316, + "iscrowd": 0, + "segmentation": [], + "text": "SKOS (Simple Knowledge Organization System) Is\na W3C Semantic Web standard for terminological\nresources such as controlled vocabularies,\nthesauri, subject headings, and taxonomies [3].\nIt provides an extensible RDF vocabulary for\ndescribing and relating concepts. In contrast to\nthe formal axiomatic language of OWL, SKOS.\nfocuses on the terminological and conceptual\naspects of knowledge organization.\n\nSKOS provides properties such as skos:prefLabel,\nskos:altLabel, and skos:definition that can be\nused to specify preferred labels, synonyms and\ndefinitions of vocabulary concepts respectively.\nThe hierarchical structure of a SKOS vocabulary is\nformed with skos: broader and skos:narrower\nproperties between concepts.\n\nAn advantage of the RDF-based SKOS over other\nflat-file formats is that vocabularies can be\npublished as part of the emerging web of linked\ndata, easily integrated with other RDF datasets,\nand processed by Semantic Web applications." + }, + { + "id": 53118, + "strid": "49a1ef57-396a-48ea-ab42-99115587fa7a", + "image_id": 202587, + "image_name": "118913.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 489.414, + 329.786, + 308.30899999999997, + 62.63499999999999 + ], + "priority": 9, + "parents": [ + 53134 + ], + "children": [ + 53124 + ], + "area": 161401.885404, + "iscrowd": 0, + "segmentation": [], + "text": "Concept Profile\nGeneration Pipeline" + }, + { + "id": 53124, + "strid": "20c3041a-3b66-443b-956e-a005861231dd", + "image_id": 202587, + "image_name": "118913.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 488.945, + 405.902, + 308.67800000000005, + 229.51900000000006 + ], + "priority": 10, + "parents": [ + 53118 + ], + "children": [], + "area": 198463.75339, + "iscrowd": 0, + "segmentation": [], + "text": "The concept profile generation pipeline\n(Fig. 2) produces concept profiles that\ncan be used for text mining purposes. It\nuses a set of concepts that are identified\nin a document corpus and determines the\nco-occurrence of concepts in text.\n\nThe components of the pipeline are build\non top of a triple store, where the input\nand results of each component are\nindicated by graphs. This facilitates the\ntracking provenance of each result. The\ncore entities in the pipeline (and thus in\nthe store) are the concepts, the text\nresources, and links between them." + }, + { + "id": 53119, + "strid": "48824e84-0abf-4342-b22f-b2f2d0b88079", + "image_id": 202587, + "image_name": "118913.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 837.823, + 319.481, + 150.69100000000003, + 28.019999999999982 + ], + "priority": 11, + "parents": [ + 53134 + ], + "children": [ + 53125 + ], + "area": 267668.529863, + "iscrowd": 0, + "segmentation": [], + "text": "Pi\neregrine" + }, + { + "id": 53125, + "strid": "92fc1340-d9d3-4cd4-bc2a-a623e8e300f8", + "image_id": 202587, + "image_name": "118913.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 835.247, + 359.7, + 283.7690000000001, + 307.40400000000005 + ], + "priority": 12, + "parents": [ + 53119 + ], + "children": [], + "area": 300438.34589999996, + "iscrowd": 0, + "segmentation": [], + "text": "The central component of the concept\nprofile generation pipeline is the\nindexing engine Peregrine [4].\nPeregrine recognizes concepts in\nhuman readable text, based on a\ndatabase (thesaurus) of known terms.\nMulti-word terms are correctly\nrecognized. If terms can represent\nmultiple concepts, Peregrine will\nattempt to disambiguate them.\n\nThe Peregrine indexer was extended\nto import of SKOS vocabularies in\naddition to its legacy ErasmusMC\nontology file format. This allows us to\nuse any SKOS vocabulary as a source\nof concepts for indexing. In particular,\ncommunity curated concept sources\nsuch as ConceptWiki [5] and BioPortal\n[6] will be used." + }, + { + "id": 53133, + "strid": "bcb11843-b69d-49d0-ad55-263878ab37e2", + "image_id": 202587, + "image_name": "118913.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 503.538, + 761.551, + 484.255, + 455.85800000000006 + ], + "priority": 13, + "parents": [ + 53134 + ], + "children": [ + 53129 + ], + "area": 383469.86743800004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 53129, + "strid": "ca60bf90-bde2-490b-8bab-ba86fa05dc72", + "image_id": 202587, + "image_name": "118913.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 938.599, + 1107.818, + 182.33900000000006, + 68.66499999999996 + ], + "priority": 14, + "parents": [ + 53133 + ], + "children": [], + "area": 1039796.8669820001, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 2. Schematic drawing of the\nConcept Profile Generation Pipeline.\nRed squares indicate the current\ndevelopment steps (SKOS format\ntranslation, SKOS import)." + }, + { + "id": 53120, + "strid": "d4d1383d-1214-4b48-a5dc-8daf816dfd0d", + "image_id": 202587, + "image_name": "118913.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 505.154, + 1302.643, + 198.54499999999996, + 28.22199999999998 + ], + "priority": 15, + "parents": [ + 53134 + ], + "children": [ + 53126 + ], + "area": 658035.322022, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 53126, + "strid": "803bb99e-92bf-4309-949c-b637256acb07", + "image_id": 202587, + "image_name": "118913.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 504.775, + 1349.702, + 291.06499999999994, + 71.81700000000001 + ], + "priority": 16, + "parents": [ + 53120 + ], + "children": [], + "area": 681295.82705, + "iscrowd": 0, + "segmentation": [], + "text": "We developed a set of components, services, and.\nworkflows for generating concept profiles for se i\ntext mining. By adhering to common standards»\nusers can extend, modify, and repurpose’ these\nitems." + }, + { + "id": 53121, + "strid": "a03f1c8d-a90c-47fa-accc-45cf52df0a3e", + "image_id": 202587, + "image_name": "118913.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 826.728, + 1303.58, + 292.81000000000006, + 33.722999999999956 + ], + "priority": 17, + "parents": [ + 53134 + ], + "children": [ + 53127 + ], + "area": 1077706.0862399999, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgments" + }, + { + "id": 53127, + "strid": "da4bf71a-62df-4146-ba2a-90ce1a15433e", + "image_id": 202587, + "image_name": "118913.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 825.879, + 1349.552, + 302.023, + 75.71000000000004 + ], + "priority": 18, + "parents": [ + 53121 + ], + "children": [], + "area": 1114566.656208, + "iscrowd": 0, + "segmentation": [], + "text": "This research was performed in the framework.pr,\nWidEver, which is funded by the Seventh Framework\nProgramme of the European Commission (Digital\nLibraries and Digital Preservation area ICT-2009 4.1\nproject reference 270192)" + }, + { + "id": 53130, + "strid": "805f4a23-b6a5-4bd3-b854-0b3a57414133", + "image_id": 202587, + "image_name": "118913.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 508.928, + 1477.698, + 360.47400000000005, + 89.40200000000004 + ], + "priority": 19, + "parents": [ + 53134 + ], + "children": [], + "area": 752041.8877440001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 53131, + "strid": "93d1256d-20ea-48fc-bfe8-eb0acbecfe29", + "image_id": 202587, + "image_name": "118913.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 891.687, + 1504.601, + 181.86299999999994, + 46.174999999999955 + ], + "priority": 20, + "parents": [ + 53134 + ], + "children": [], + "area": 1341633.151887, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 85601, + "strid": "bb08693c-7adb-4756-b639-848141cf4bfe", + "image_id": 203830, + "image_name": "120994.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 49.7, + 156.7, + 237.46000000000004, + 364.89000000000004 + ], + "priority": -1, + "parents": [], + "children": [ + 85592, + 85597, + 85586, + 85587, + 85595, + 85583, + 85588, + 85584 + ], + "area": 7787.99, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 85583, + "strid": "f8f1dd5f-3563-4261-9531-2540eae227e5", + "image_id": 203830, + "image_name": "120994.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 183.889, + 47.78, + 3751.141, + 295.587 + ], + "priority": 1, + "parents": [ + 85601 + ], + "children": [], + "area": 8786.21642, + "iscrowd": 0, + "segmentation": [], + "text": "A Generab Strategy for the Bioorthogonat ‘Incorporation of Strongly\nAbsorbing, Solvation-Sensitive Infrared Probes into Proteins\n\nAw" + }, + { + "id": 85584, + "strid": "acd2dfff-2581-49a1-ae5b-75f54a08bee6", + "image_id": 203830, + "image_name": "120994.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 190.927, + 392.631, + 3930.604, + 453.937 + ], + "priority": 2, + "parents": [ + 85601 + ], + "children": [], + "area": 74963.858937, + "iscrowd": 0, + "segmentation": [], + "text": "lvan Peran', Tracey Oudenhoven2, Ann Marie Woys?, Matthew D. Watson’, Tiangi.O. Zhang?, Isaac Carricot) Martin T.\nZanni*, and Daniel P. Raleigh’\n\n1. Department of Chemistry, Stony Brook University, Stony-Brook, New York 11794-3400\n2. Department of-Chemistry, University of Wisconsin, 1101 UniversityAAvenue, Madison, Wisconsin, 53706-1396" + }, + { + "id": 85588, + "strid": "b4c4ab05-e30e-499b-9871-39f0ca9378cf", + "image_id": 203830, + "image_name": "120994.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 685.32, + 962.029, + 294.101, + 78.85300000000007 + ], + "priority": 3, + "parents": [ + 85601 + ], + "children": [ + 85585 + ], + "area": 659297.7142800001, + "iscrowd": 0, + "segmentation": [], + "text": "Abstract" + }, + { + "id": 85585, + "strid": "49539560-7cda-40e9-9841-b17b5b786799", + "image_id": 203830, + "image_name": "120994.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 181.552, + 1076.292, + 1300.073, + 889.0540000000001 + ], + "priority": 4, + "parents": [ + 85588 + ], + "children": [], + "area": 195402.96518399997, + "iscrowd": 0, + "segmentation": [], + "text": "A high sensitivity metal‘carbonyl based IR probe is described which can\nbe incorporated into.proteins or other bio-molecules in very high yield via\nClick chemistry.“A.two step strategy is demonstrated. First, a methionine\nauxotroph is uséd to incorporate the unnatural amino acid\nazidohomoalanine at high levels. Second, a tricarbonyl (n°-\ncyclopentadienyl) rhenium(l) probe modified with an alkynyltinkage is\ncoupled via the Click reaction. We demonstrate these steps using the C-\nterminal domain of the ribosomal protein L9 as a model system. An\noverall incorporation level of 92 % was obtained at.K109, which is a\nsurface exposed residue. Incorporation of the.probe into a surface site is\nshown not to perturb the stability or structure of the target protein. Metal\ncarbonyls are known to be sensitive to solvation and protein electrostatics\nthrough vibrational lifetimes and frequency shifts. In this paper, we report\nthat the frequencies and lifetimes of this probe also depend on the\nisotopic composition of the solvent. Comparison of the lifetimes measured\nin H,O versus D,O provides, a_probe of solvent accessibility. The metal\ncarbonyl probe reported here‘provides an easy and robust method to\nlabel very large proteins with an amino acid specific tag that is both\nenvironmentally sensitive’and a very strong absorber." + }, + { + "id": 85597, + "strid": "bc741e9d-122b-4e80-b5e7-418d6793ab6f", + "image_id": 203830, + "image_name": "120994.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 211.111, + 2163.813, + 1261.665, + 167.317 + ], + "priority": 5, + "parents": [ + 85601 + ], + "children": [ + 85599, + 85598 + ], + "area": 456804.726243, + "iscrowd": 0, + "segmentation": [], + "text": "Bioorthogonal Incorporationof Metal\ng@ CarbonvI IR Probes" + }, + { + "id": 85598, + "strid": "c6f666af-7cb4-40ed-8e9b-50dba28f3203", + "image_id": 203830, + "image_name": "120994.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 271.377, + 2369.345, + 1044.183, + 751.373 + ], + "priority": 6, + "parents": [ + 85597 + ], + "children": [], + "area": 642985.7380649999, + 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"category_id": 2, + "category_name": "Figure", + "bbox": [ + 1538.379, + 1215.613, + 1248.7200000000003, + 762.385 + ], + "priority": 9, + "parents": [ + 85586 + ], + "children": [], + "area": 1870073.5113269999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 85592, + "strid": "f2e0d040-11db-4700-a138-4420f1c5c971", + "image_id": 203830, + "image_name": "120994.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1544.411, + 2119.73, + 1261.7650000000003, + 170.79500000000007 + ], + "priority": 10, + "parents": [ + 85601 + ], + "children": [ + 85594, + 85593 + ], + "area": 3273734.32903, + "iscrowd": 0, + "segmentation": [], + "text": "The Frequency of the Metal Carbonyl\nProbe is Sensitive to Environment c" + }, + { + "id": 85593, + "strid": "0aaf98e9-8a4c-4a0b-9458-0202ae212b15", + "image_id": 203830, + "image_name": "120994.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1526.524, + 2357.373, + 1229.9029999999998, + 874.2689999999998 + ], 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+ "id": 85600, + "strid": "eaa2b3a6-13c2-4bee-bea3-9969edf7d46c", + "image_id": 203830, + "image_name": "120994.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2994.43, + 1163.95, + 1015.2329999999997, + 826.9779999999998 + ], + "priority": 14, + "parents": [ + 85587 + ], + "children": [], + "area": 3485366.7985, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 85590, + "strid": "ff2bb55d-e097-43a6-b9a9-b718d36d13fb", + "image_id": 203830, + "image_name": "120994.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2872.301, + 2021.593, + 1222.7959999999998, + 167.34399999999982 + ], + "priority": 15, + "parents": [ + 85587 + ], + "children": [], + "area": 5806623.595493, + "iscrowd": 0, + "segmentation": [], + "text": "(A) 2D IR*Spectrum in HO, (B) 2D IR Spectrum in D,O, (C) Intensity.of the\ndiagonalpeak of the symmetric stretch (circles) with single exponential fits (lines),\n(D) Intensity of the diagonal peak of the asymmetric stretch(circles) with single\nexponential fits (lines)" + }, + { + "id": 85591, + "strid": "99a67503-f7c9-418c-926a-2e03003ce2c4", + "image_id": 203830, + "image_name": "120994.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2871.915, + 2214.746, + 1251.1570000000002, + 219.27700000000004 + ], + "priority": 16, + "parents": [ + 85587 + ], + "children": [], + "area": 6360562.25859, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 85595, + "strid": "ee897638-fe5f-4f43-9b1d-942a829ec385", + "image_id": 203830, + "image_name": "120994.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3300.34, + 2507.994, + 399.53499999999985, + 73.47800000000007 + ], + "priority": 17, + "parents": [ + 85601 + ], + "children": [ + 85596 + ], + "area": 8277232.917960001, + "iscrowd": 0, + "segmentation": [], + "text": "Gonclusions" + }, + { + "id": 85596, + "strid": "5d58cf4b-b4be-46ba-b4da-77ea2155000d", + "image_id": 203830, + "image_name": "120994.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2875.858, + 2595.443, + 1254.7610000000004, + 364.91899999999987 + ], + "priority": 18, + "parents": [ + 85595 + ], + "children": [], + "area": 7464125.515094001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 5658, + "strid": "90b0caec-aad8-4291-8dd0-43795c6375d2", + "image_id": 200729, + "image_name": "10723.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 58.38, + 65.08, + 71.80000000000001, + 71.79 + ], + "priority": -1, + "parents": [], + "children": [ + 5636, + 5637, + 5635, + 5656, + 5633, + 5655, + 5634, + 5632 + ], + "area": 3799.3704000000002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 5632, + "strid": "e5e7e9c7-d34a-4595-b739-565179c0a89d", + "image_id": 200729, + "image_name": "10723.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 140.332, + 109.734, + 4196.432, + 304.542 + ], + "priority": 1, + "parents": [ + 5658 + ], + "children": [], + "area": 15399.191687999999, + "iscrowd": 0, + "segmentation": [], + "text": "The Role of Exercises in Osteoporotic Fracture Prevention and Current Care Gaps\nWhere Are We Now? Recent Updates" + }, + { + "id": 5655, + "strid": "75efcccb-328c-4d3c-a24a-36d153a1a77e", + "image_id": 200729, + "image_name": "10723.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1559.874, + 495.12, + 1348.82, + 468.27 + ], + "priority": 2, + "parents": [ + 5658 + ], + "children": [], + "area": 772324.81488, + "iscrowd": 0, + "segmentation": [], + "text": "Helen Senderovich (MD MCFP (COE), (PC))!:2>\",\nHenry Tang\", Samuel Belmont (BMSc)\"\n\n'Baycrest Health Sciences, Faculty of Medicine,\nUniversity of Toronto, Toronto, Canada;\n3Department of Family and Community Medicine,\nDivision of Palliative Care." + }, + { + "id": 5633, + "strid": "1c5ea8b5-3ff2-4116-b704-d78f426137c1", + "image_id": 200729, + "image_name": "10723.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 657.201, + 485.776, + 269.418, + 57.13500000000005 + ], + "priority": 3, + "parents": [ + 5658 + ], + "children": [ + 5639, + 5638, + 5641, + 5640, + 5642 + ], + "area": 319252.472976, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 5638, + "strid": "4214728f-ab2c-4306-ab9c-6946b3f60b1d", + "image_id": 200729, + "image_name": "10723.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 95.127, + 610.602, + 1370.511, + 207.663 + ], + "priority": 4, + "parents": [ + 5633 + ], + "children": [], + "area": 58084.736454, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction\nThe primary non-pharmacological management recommended for patients\n\nwith osteoporosis (OP) is exercise, but whether it should be high force, resistive,\nor other means can be obscure." + }, + { + "id": 5639, + "strid": "93a1ecc6-4284-45de-8529-eb7792a23651", + "image_id": 200729, + "image_name": "10723.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 96.079, + 859.365, + 1390.498, + 215.24299999999994 + ], + "priority": 5, + "parents": [ + 5633 + ], + "children": [], + "area": 82566.92983499999, + "iscrowd": 0, + "segmentation": [], + "text": "Objective\n\nTo describe the role of exercises in osteoporotic fracture prevention, identify\neffects and potential risks of high-force exercises, detect the optimal exercises to\ncombat OP, and explore the challenges that might arise from interventions." + }, + { + "id": 5640, + "strid": "f0109808-44ee-4c8d-a614-b74e50cb4d0a", + "image_id": 200729, + "image_name": "10723.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 97.243, + 1109.142, + 1381.711, + 381.9200000000001 + ], + "priority": 6, + "parents": [ + 5633 + ], + "children": [], + "area": 107856.295506, + "iscrowd": 0, + "segmentation": [], + "text": "Methods\n\nA MEDLINE, and a Cochrane databases search was conducted on the role of\nexercises in preventing osteoporotic fractures from 1989 onwards, leading to 40\nresults, including op-ed pieces, qualitative studies, randomized clinical trials\n(RCTs) (n = 5),and RCT follow up studies (n = 1). Articles deemed relevant to the\nobjective hands were analyzed and summarized. Data on effects of Vitamin D\nand Calcium supplementation was later gathered from different sources as well." + }, + { + "id": 5641, + "strid": "dee8df89-d185-4766-85de-e5c5291e2f49", + "image_id": 200729, + "image_name": "10723.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 98.246, + 1526.533, + 1381.801, + 437.23 + ], + "priority": 7, + "parents": [ + 5633 + ], + "children": [], + "area": 149975.761118, + "iscrowd": 0, + "segmentation": [], + "text": "Results\n\nHigh-intensity, resistive strength training provided the maximum benefit in\nincreasing Bone Mineral Density (BMD) levels, muscle mass and reduction in\nfracture, while posture and balance exercises only improved mobility. High force\nexercises did not increase fractures, and were associated with increases in BMD.\nInterventions including exercises, Vitamin D and calcium intake had limited\neffect when used as single interventions, while Vitamin D and calcium intake\nmay potentially cause increases of Cardiovascular events." + }, + { + "id": 5642, + "strid": "2e6a4497-c882-4bf3-b00b-4263680a33e4", + "image_id": 200729, + "image_name": "10723.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 96.957, + 1998.297, + 1379.458, + 214.88799999999992 + ], + "priority": 8, + "parents": [ + 5633 + ], + "children": [], + "area": 193748.88222899998, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion\n\nA long term regular exercise programme designed to improve postural stability,\nmobility, and mechanical efficiency, alongside Vitamin D and dietary Calcium\nintake is most effective in preventing OP and reducing osteoporotic fractures." + }, + { + "id": 5634, + "strid": "fd82c283-c301-416a-8366-e4035e343e96", + "image_id": 200729, + "image_name": "10723.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 603.445, + 2273.281, + 380.0880000000001, + 69.2170000000001 + ], + "priority": 9, + "parents": [ + 5658 + ], + "children": [ + 5643, + 5650 + ], + "area": 1371800.0530450002, + "iscrowd": 0, + "segmentation": [], + "text": "Background" + }, + { + "id": 5643, + "strid": "9fb3054a-ea35-4008-9d70-0e4fd77122a5", + "image_id": 200729, + "image_name": "10723.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 97.357, + 2399.11, + 1356.741, + 154.3420000000001 + ], + "priority": 10, + "parents": [ + 5634 + ], + "children": [], + "area": 233570.15227000002, + "iscrowd": 0, + "segmentation": [], + "text": "Osteoporosis (OP) is an incurable weakening of bone structure due to loss of\ntissue from mineral deficiency in the elderly.' It is the leading cause of death in\nthe elderly due to its high incidence rate.”" + }, + { + "id": 5650, + "strid": "4727efc7-7d65-46e8-b5a5-4100c6ff5188", + "image_id": 200729, + "image_name": "10723.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 93.992, + 2566.983, + 1394.173, + 696.058 + ], + "priority": 11, + "parents": [ + 5634 + ], + "children": [], + "area": 241275.86613600003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 5656, + "strid": "5a4fc1f5-06e9-4469-b880-5ab323e646a3", + "image_id": 200729, + "image_name": "10723.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1586.608, + 1090.375, + 1300.206, + 1330.591 + ], + "priority": 12, + "parents": [ + 5658 + ], + "children": [], + "area": 1729997.6979999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 5635, + "strid": "8c614266-9eeb-455c-8ae2-1e3022957d62", + "image_id": 200729, + "image_name": "10723.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1788.37, + 2520.219, + 900.19, + 70.5039999999999 + ], + "priority": 13, + "parents": [ + 5658 + ], + "children": [ + 5644 + ], + "area": 4507084.05303, + "iscrowd": 0, + "segmentation": [], + "text": "Effects of High Force Exercise" + }, + { + "id": 5644, + "strid": "5b656ecf-dd81-46ea-a70c-85223932c803", + "image_id": 200729, + "image_name": "10723.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1546.073, + 2644.905, + 1373.927, + 488.4850000000001 + ], + "priority": 14, + "parents": [ + 5635 + ], + "children": [], + "area": 4089216.2080650004, + "iscrowd": 0, + "segmentation": [], + "text": "The immediate step to take for anybody to strengthen bone health is to\nundergo regular vigorous exercise. Among other things, it has been found that\nexercises may help to maintain mobility, physicality, BMD, muscle, strength and\nbalance.’ Together, these benefits have attributed to a small but statistically\nsignificant reduction in falls, particularly when the exercise program specifically\ninvolves balance and lower body strength training, which is may be associated\nwith a reduction up to 40% in hip fractures.* Despite concern from many\nosteoporotic patients that exercise increases the risk of fractures, data suggests\ninjury rate actually decline, and severe damage is non-existent.'*" + }, + { + "id": 5636, + "strid": "4bf8a0e5-356b-401b-9a2a-ce1d72355a56", + "image_id": 200729, + "image_name": "10723.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3268.661, + 483.976, + 836.1869999999999, + 70.005 + ], + "priority": 15, + "parents": [ + 5658 + ], + "children": [ + 5645, + 5653, + 5648, + 5654, + 5647, + 5652, + 5646, + 5651 + ], + "area": 1581953.4761360001, + "iscrowd": 0, + "segmentation": [], + "text": "Effective Types of Exercises" + }, + { + "id": 5645, + "strid": "4aa6f2f2-3427-4bdd-9ad6-bc1f1f041e59", + "image_id": 200729, + "image_name": "10723.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2986.933, + 608.679, + 908.9749999999999, + 436.94999999999993 + ], + "priority": 16, + "parents": [ + 5636 + ], + "children": [], + "area": 1818083.391507, + "iscrowd": 0, + "segmentation": [], + "text": "Strength Training\n\nThe most effective form of exercise,6 strength\ntraining increases muscle mass, which is often an\nissue in the elderly; by age 70 people are expected\nto lose between 50%-55% of their max muscle mass.\nStrength training may also increase BMD in certain\nparts of the body, including the spine and hip bone,\nreducing fracture risk.”" + }, + { + "id": 5651, + "strid": "d0c277f6-910a-49bc-b179-7c46a68d3e78", + "image_id": 200729, + "image_name": "10723.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3930.699, + 615.729, + 437.9050000000002, + 437.72900000000004 + ], + "priority": 17, + "parents": [ + 5636 + ], + "children": [], + "area": 2420245.364571, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 5652, + "strid": "65a962aa-dbd7-4ebd-8038-e2b18ab5d136", + "image_id": 200729, + "image_name": "10723.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2987.287, + 1103.82, + 458.52, + 443.49199999999996 + ], + "priority": 18, + "parents": [ + 5636 + ], + "children": [], + "area": 3297427.1363399997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 5646, + "strid": "6890444a-d921-4718-b2c7-04a3f940bdc1", + "image_id": 200729, + "image_name": "10723.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3477.59, + 1123.036, + 913.8429999999998, + 430.568 + ], + "priority": 19, + "parents": [ + 5636 + ], + "children": [], + "area": 3905458.7632400002, + "iscrowd": 0, + "segmentation": [], + "text": "Posture Training\n\nPosture training involves proper alignment and\npositioning of various body parts, especially the\nspine. The aim of posture training is to strengthen\nmuscles along the back and the hip, the areas most\naffected by OP, and improve alignment of the spine\nSo small twists and loads upon the vertebrae will not\nresult in fractures.®" + }, + { + "id": 5647, + "strid": "e4132fde-186b-4316-b95c-4a315278a57f", + "image_id": 200729, + "image_name": "10723.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2989.502, + 1630.189, + 886.9699999999998, + 319.73299999999995 + ], + "priority": 20, + "parents": [ + 5636 + ], + "children": [], + "area": 4873453.275878, + "iscrowd": 0, + "segmentation": [], + "text": "Balance Training\n\nBalance training exercises are those that work to\nimprove balance and reduce falls, by enhancing leg\nmuscles. Results have demonstrated greater\nmobility, and improved functional and static\nbalance.?" + }, + { + "id": 5653, + "strid": "bcf3be31-c071-4b9f-abcf-f5a72b046490", + "image_id": 200729, + "image_name": "10723.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3937.822, + 1565.24, + 440.3069999999998, + 445.876 + ], + "priority": 21, + "parents": [ + 5636 + ], + "children": [], + "area": 6163636.5072800005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 5654, + "strid": "c0194a4f-b38d-4226-a5f8-9643afe18933", + "image_id": 200729, + "image_name": "10723.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2982.438, + 2038.082, + 429.90200000000004, + 417.26700000000005 + ], + "priority": 22, + "parents": [ + 5636 + ], + "children": [], + "area": 6078453.203916, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 5648, + "strid": "861ddb2a-de7e-4aa4-b5da-59cbf22d711f", + "image_id": 200729, + "image_name": "10723.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3473.984, + 2035.192, + 914.6380000000004, + 375.97800000000007 + ], + "priority": 23, + "parents": [ + 5636 + ], + "children": [], + "area": 7070224.444928, + "iscrowd": 0, + "segmentation": [], + "text": "Aerobic Training\n\nAerobic training is any physical activity that\nincreases heart and breathing rate, and can be\nperformed continuously for periods of time. The\npurpose of aerobic training is to strengthen the\nheart and lungs, and increase muscle mass and BMD,\nwhich reduces chance of fractures.!°" + }, + { + "id": 5637, + "strid": "4004bea8-4647-48fd-a077-04e980093b99", + "image_id": 200729, + "image_name": "10723.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3382.428, + 2518.045, + 605.355, + 60.75799999999981 + ], + "priority": 24, + "parents": [ + 5658 + ], + "children": [ + 5649, + 5657 + ], + "area": 8517105.91326, + "iscrowd": 0, + "segmentation": [], + "text": "References/Contact" + }, + { + "id": 5649, + "strid": "341eb8f6-59fb-4aa0-9068-a92f32fd7ca3", + "image_id": 200729, + "image_name": "10723.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2993.758, + 2648.017, + 1383.0609999999997, + 557.3049999999998 + ], + "priority": 25, + "parents": [ + 5637 + ], + "children": [], + "area": 7927522.077885999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 5657, + "strid": "ae31590d-b6f3-4fef-b79d-885883d6ac35", + "image_id": 200729, + "image_name": "10723.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2993.868, + 3242.723, + 721.531, + 31.744000000000142 + ], + "priority": 26, + "parents": [ + 5637 + ], + "children": [], + "area": 9708284.622564, + "iscrowd": 0, + "segmentation": [], + "text": "For inquiry: please contact Dr. H. Senderovich at hsenderovich@baycrest.org" + }, + { + "id": 70527, + "strid": "a6db9a90-c466-4729-b134-4e3fb8132069", + "image_id": 203250, + "image_name": "119938.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 1462.21, + 40.58, + 436.4200000000001, + 359.40000000000003 + ], + "priority": -1, + "parents": [], + "children": [ + 70505, + 70503, + 70507, + 70506, + 70508, + 70504 + ], + "area": 59336.4818, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 70503, + "strid": "a12bc88c-c4f9-403d-872e-4a5d73bc3fb5", + "image_id": 203250, + "image_name": "119938.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 2385.397, + 121.345, + 3823.6089999999995, + 283.876 + ], + "priority": 1, + "parents": [ + 70527 + ], + "children": [], + "area": 289455.998965, + "iscrowd": 0, + "segmentation": [], + "text": "The relation between the acuity of Approximate Number System\nand the dorsal and ventral stream functions" + }, + { + "id": 70504, + "strid": "06000aba-19db-45c2-8649-82ec05c55597", + "image_id": 203250, + "image_name": "119938.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 2574.582, + 415.319, + 3440.686, + 156.99999999999994 + ], + "priority": 2, + "parents": [ + 70527 + ], + "children": [], + "area": 1069272.821658, + "iscrowd": 0, + "segmentation": [], + "text": "Giovagnoli S', Benassi M?, Hellgren K’, Forsman L? @nd Bolzani R'" + }, + { + "id": 70506, + "strid": "7e4716c0-7581-4714-bc83-ce4eb29d0cc9", + "image_id": 203250, + "image_name": "119938.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 387.303, + 655.202, + 966.3580000000001, + 100.59500000000003 + ], + "priority": 3, + "parents": [ + 70527 + ], + "children": [ + 70509 + ], + "area": 253761.700206, + "iscrowd": 0, + "segmentation": [], + "text": "INTRODUC" + }, + { + "id": 70509, + "strid": "8f3ae794-e6ba-46b3-bc24-656206044ebf", + "image_id": 203250, + "image_name": "119938.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 326.749, + 934.042, + 1109.617, + 1386.4 + ], + "priority": 4, + "parents": [ + 70506 + ], + "children": [], + "area": 305197.28945800004, + "iscrowd": 0, + "segmentation": [], + "text": "Children and adults can approxi-\nmate*number of objects and per-\nform approximate arithmetic op-\nerations via a non-symbolic, pre-\nlinguistic system called the Ap-\nproximate Number System (ANS).\nStudies using neuroimaging tech?\nniques showed the role of the pa-\nrietal cortex in decoding_non-\nsymbolic quantity. Although jit has\nbeen demonstrated that the pari-\netal regions are involved also in\nvisual processing,such as coher-\nence motion perception, little is\nknown about.the relationship be-\ntween visual-orocesses and the\nANS." + }, + { + "id": 70507, + "strid": "8a7b4611-7098-49f6-9601-b93b2a31cdb6", + "image_id": 203250, + "image_name": "119938.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 735.88, + 2828.774, + 266.70799999999997, + 113.76999999999998 + ], + "priority": 5, + "parents": [ + 70527 + ], + "children": [ + 70510 + ], + "area": 2081638.2111199999, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 70510, + "strid": "3ab4d93e-16ad-48f6-a0da-ecd66ff2284b", + "image_id": 203250, + "image_name": "119938.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 310.628, + 3200.093, + 1126.242, + 442.3539999999998 + ], + "priority": 6, + "parents": [ + 70507 + ], + "children": [], + "area": 994038.488404, + "iscrowd": 0, + "segmentation": [], + "text": "The aim of this study:isto inves-\ntigate whether the acuity in the\nApproximate Number System\n(ANS) is related to dorsal and\nventral visual functions." + }, + { + "id": 70505, + "strid": "c3de52b3-85e0-4513-ac43-636c5a61d13f", + "image_id": 203250, + "image_name": "119938.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3790.799, + 682.318, + 607.9290000000001, + 96.97000000000003 + ], + "priority": 7, + "parents": [ + 70527 + ], + "children": [ + 70514, + 70517, + 70512, + 70513, + 70519, + 70518, + 70511 + ], + "area": 2586530.392082, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 70511, + "strid": "4ad0cf04-bd10-451c-8a68-9867362ca326", + "image_id": 203250, + "image_name": "119938.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2941.905, + 852.605, + 2325.2860000000005, + 161.664 + ], + "priority": 8, + "parents": [ + 70505 + ], + "children": [], + "area": 2508282.912525, + "iscrowd": 0, + "segmentation": [], + "text": "Participants\n65 typical development children (age 6-10 years; 42 males‘and 23 females)" + }, + { + "id": 70518, + "strid": "4cba9ea2-6394-4afa-8a62-13d0c71bb005", + "image_id": 203250, + "image_name": "119938.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2002.006, + 1156.56, + 1515.778, + 899.2049999999999 + ], + "priority": 9, + "parents": [ + 70505 + ], + "children": [ + 70515 + ], + "area": 2315440.05936, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 70515, + "strid": "23b5bf0b-6c29-4a5f-9e4b-3e4b0a457a70", + "image_id": 203250, + "image_name": "119938.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2010.19, + 2068.908, + 502.11400000000003, + 57.47499999999991 + ], + "priority": 10, + "parents": [ + 70518 + ], + "children": [], + "area": 4158898.17252, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. | Panamath Test" + }, + { + "id": 70512, + "strid": "1fb439bc-2eba-4c66-b4c6-74cfd4647f7b", + "image_id": 203250, + "image_name": "119938.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3837.45, + 1092.544, + 2015.6530000000002, + 856.085 + ], + "priority": 11, + "parents": [ + 70505 + ], + "children": [], + "area": 4192582.9728, + "iscrowd": 0, + "segmentation": [], + "text": "Stimuli\n\n \n\nANS acuity was ‘measured using a numerical discrimination task\ncalled Panamath (Halberda et al., 2008). Participants were\nbriefly shown-arrays of yellow and blue dots and had to identify\nthe moreynumerous array (see Fig.1). The test has 4 difficulty level\ncalibrated according to age. The difficulty is given_bythe ratio\nbetween the quantities of the two sets of dots (Weber Fraction).\nThe performance of the subject had been assessed by Weber\nIndex." + }, + { + "id": 70513, + "strid": "4a343691-7942-4dbf-b392-3c8dcb78d302", + "image_id": 203250, + "image_name": "119938.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2042.268, + 2214.796, + 1978.7579999999998, + 901.0459999999998 + ], + "priority": 12, + "parents": [ + 70505 + ], + "children": [], + "area": 4523206.997328, + "iscrowd": 0, + "segmentation": [], + "text": "A motion coherence test and a form coherence test were ap-\nplied to evaluate dorsal and ventral stream functions respec-\ntively.\n\nIn the motion test participants were asked to detect the direc-\ntion of moving dots (see Fig.2) The test consists of 5 difficulty\nlevels (i.e. the coherence decreases by 2 db in each level). The\ndifficulty is given by the ratio between the coherently moving\ndots and brownian meving dots. The percentage of correct\nanswers had been usedvas measure of motion perception ac-\ncuracy." + }, + { + "id": 70519, + "strid": "c786dd77-ccae-44a6-b6c1-3a0e30c8220b", + "image_id": 203250, + "image_name": "119938.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1997.582, + 3185.673, + 1728.7829999999997, + 855.73 + ], + "priority": 13, + "parents": [ + 70505 + ], + "children": [ + 70520 + ], + "area": 6363643.042686, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 70520, + "strid": "edc9a7f9-5921-4b29-94fe-00daa6289c09", + "image_id": 203250, + "image_name": "119938.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2003.092, + 4052.837, + 656.8089999999997, + 56.593999999999596 + ], + "priority": 14, + "parents": [ + 70519 + ], + "children": [], + "area": 8118205.3720040005, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 3 Form Coherence Test" + }, + { + "id": 70517, + "strid": "9407e967-646f-4b6b-b0e8-8d5946676424", + "image_id": 203250, + "image_name": "119938.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 4218.741, + 2144.473, + 1682.9130000000005, + 971.4929999999999 + ], + "priority": 15, + "parents": [ + 70505 + ], + "children": [ + 70516 + ], + "area": 9046976.168492999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 70516, + "strid": "408f9ac3-8e2b-4f6b-abca-21376f9a9f43", + "image_id": 203250, + "image_name": "119938.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 4219.345, + 3125.607, + 713.1959999999999, + 59.36999999999989 + ], + "priority": 16, + "parents": [ + 70517 + ], + "children": [], + "area": 13188014.267415, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 2 Motion Coherence Test" + }, + { + "id": 70514, + "strid": "289df703-ec2c-4541-9351-5bce1363a2ea", + "image_id": 203250, + "image_name": "119938.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4197.325, + 3398.553, + 1630.179, + 563.0830000000001 + ], + "priority": 17, + "parents": [ + 70505 + ], + "children": [], + "area": 14264831.470724998, + "iscrowd": 0, + "segmentation": [], + "text": "In the form test participants had)fto recognize a form\ncreated by spatially aligned dots (see Fig.3).\n\nThe test consists of 5 difficulty levels: the coherence\n\ndecreases by 3 db in-each level (the percentage of\n\nspatially aligned det.decreased by 50%). The perfor-\n\nmance of the subject is given by the percentage of\ncorrect answers." + }, + { + "id": 70508, + "strid": "2c046673-a1de-4fe6-88ab-797831b3dc1c", + "image_id": 203250, + "image_name": "119938.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 7296.883, + 650.029, + 624.3729999999996, + 106.11900000000003 + ], + "priority": 18, + "parents": [ + 70527 + ], + "children": [ + 70523, + 70524, + 70525, + 70526 + ], + "area": 4743185.559607, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 70525, + "strid": "a6c76fb6-281d-4f88-a071-f68fde6d0ad2", + "image_id": 203250, + "image_name": "119938.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 6416.58, + 920.979, + 607.1589999999997, + 2668.2339999999995 + ], + "priority": 19, + "parents": [ + 70508 + ], + "children": [], + "area": 5909535.4318200005, + "iscrowd": 0, + "segmentation": [], + "text": "A significant cor-\nrelation between\nANS acuity and\nmotion percep-\ntion ability\n(0=0.014) as well\nas between ANS\nacuity and form\ndiscrimination\nability (p=0.046)\n\nhas beenfound.\n\nMoresspecifically,\nhigher perfor-\nmance in the mo-\ntion and form\ntests are related\nto higher ANS\nacuity.\n\nThe effect size\nevaluation show\nmedium magni-\ntude for the rela-\ntionship between\nthe ANS and both\nthe motion coher-\nence test-(partial\nn?=0.09) and the\nformycoherence\n\ntest (partial\nn2=0.06 )." + }, + { + "id": 70524, + "strid": "7cacd9f5-e35a-444a-b2ea-b6a15921c732", + "image_id": 203250, + "image_name": "119938.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 7223.437, + 919.708, + 1460.6810000000005, + 1161.866 + ], + "priority": 20, + "parents": [ + 70508 + ], + "children": [ + 70521 + ], + "area": 6643452.796395999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 70521, + "strid": "c79a683e-98f0-4733-9444-dba3fa0401f7", + "image_id": 203250, + "image_name": "119938.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 7343.84, + 2113.705, + 1371.3600000000006, + 58.60199999999986 + ], + "priority": 21, + "parents": [ + 70524 + ], + "children": [], + "area": 15522711.3272, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 4 Correlation between ANS acuity and Motion Score" + }, + { + "id": 70523, + "strid": "fa3c51bf-032f-4cee-8723-9ae4faf67150", + "image_id": 203250, + "image_name": "119938.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 7208.493, + 2332.442, + 1485.7260000000006, + 1179.5749999999998 + ], + "priority": 22, + "parents": [ + 70508 + ], + "children": [ + 70522 + ], + "area": 16813391.829906, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 70522, + "strid": "57ec0f2f-4f8a-4d38-bb4d-12e106d2dc86", + "image_id": 203250, + "image_name": "119938.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 7339.921, + 3546.71, + 1318.9449999999997, + 59.13500000000022 + ], + "priority": 23, + "parents": [ + 70523 + ], + "children": [], + "area": 26032571.20991, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 5 Correlation between ANS acuity and Form Score" + }, + { + "id": 70526, + "strid": "4d45ba5d-473b-4802-beea-43334c2be34b", + "image_id": 203250, + "image_name": "119938.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 6434.053, + 3708.375, + 2212.6460000000006, + 327.7260000000001 + ], + "priority": 24, + "parents": [ + 70508 + ], + "children": [], + "area": 23859881.293875, + "iscrowd": 0, + "segmentation": [], + "text": "These results demonstrate that the numerical discrimination evaluat-\ned by Panamath fest is related bothNo dorsal and ventral visual per-\nception ability suggesting the connection between these visual\nfunctions and Appreximate Number System." + }, + { + "id": 90877, + "strid": "29c2b96d-be2b-42a9-8ced-64c781528309", + "image_id": 204025, + "image_name": "121342.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 70.45, + 103.97, + 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"iscrowd": 0, + "segmentation": [], + "text": "Dea Schréder', Coby Wijnen’, Gerdienke Prange*\n\n1. Roessingh Department of Dietetics, Enschede, the Netherlands\n2. Dutch Association for neuromuscular diseases (VSN), Department of Dietetics, Baarn, the Netherlands\n3. Roessingh Research and Development, Enschede, the Netherlands" + }, + { + "id": 90862, + "strid": "43200ea7-a4f3-4ad3-a74e-f3ef63987aaa", + "image_id": 204025, + "image_name": "121342.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3171.032, + 821.084, + 133.05099999999993, + 76.26099999999997 + ], + "priority": 3, + "parents": [ + 90877 + ], + "children": [], + "area": 2603683.638688, + "iscrowd": 0, + "segmentation": [], + "text": "P75" + }, + { + "id": 90870, + "strid": "aceca819-7283-4056-8781-121ba9546e54", + "image_id": 204025, + "image_name": "121342.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 654.596, + 1086.735, + 509.807, + 111.9090000000001 + ], + "priority": 4, + "parents": [ + 90877 + ], + "children": [ + 90863 + ], + "area": 711372.38406, + "iscrowd": 0, + "segmentation": [], + "text": "Background" + }, + { + "id": 90863, + "strid": "ec14ac59-b32f-4f15-a0c6-70fba4ea6226", + "image_id": 204025, + "image_name": "121342.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 353.132, + 1240.609, + 1075.253, + 124.70699999999988 + ], + "priority": 5, + "parents": [ + 90870 + ], + "children": [], + "area": 438098.73738799995, + "iscrowd": 0, + "segmentation": [], + "text": "After PEG placement weight loss continues although\nto a smaller extent than before PEG placement." + }, + { + "id": 90871, + "strid": "57734d30-c2f5-4567-838a-702274329b98", + "image_id": 204025, + "image_name": "121342.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2261.634, + 1088.807, + 447.90099999999984, + 111.18900000000008 + ], + "priority": 6, + "parents": [ + 90877 + ], + "children": [ + 90864 + ], + "area": 2462482.930638, + "iscrowd": 0, + "segmentation": [], + "text": "Objectives" + }, + { + "id": 90864, + "strid": "00974777-49fc-4e99-91c7-9fe10df8ee08", + "image_id": 204025, + "image_name": "121342.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1930.464, + 1247.125, + 1088.2960000000003, + 116.6389999999999 + ], + "priority": 7, + "parents": [ + 90871 + ], + "children": [], + "area": 2407529.9159999997, + "iscrowd": 0, + "segmentation": [], + "text": "To investigate possible causes of ongoing weight loss\ndespite dietetical interventions." + }, + { + "id": 90873, + "strid": "e6d41ea2-0aed-4412-9ff1-5fbbc055c910", + "image_id": 204025, + "image_name": "121342.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 719.418, + 1641.911, + 378.0279999999999, + 88.7940000000001 + ], + "priority": 8, + "parents": [ + 90877 + ], + "children": [ + 90869 + ], + "area": 1181220.327798, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 90869, + "strid": "2b1eb01e-c3c2-4fb5-b9da-76e5a5a7b0e3", + "image_id": 204025, + "image_name": "121342.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 349.739, + 1791.59, + 1078.759, + 596.1939999999997 + ], + "priority": 9, + "parents": [ + 90873 + ], + "children": [], + "area": 626588.89501, + "iscrowd": 0, + "segmentation": [], + "text": "We retrospectively studied the records of patients\ndischarged from rehabilitation or deceased between\nJanuary 2010 and July 2013. 48 patients (22 men;\nmean age at diagnosis 63 years) were included; 33\npatients had a bulbar and 15 a spinal debut.\n\nAll patients were followed for at least 6 months\nafter PEG placement. Weight, estimated energy\nrequirements and dietetical interventions were\nmeasured." + }, + { + "id": 90872, + "strid": "80db5276-f373-41a2-90c1-0548d87b833e", + "image_id": 204025, + "image_name": "121342.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2338.499, + 1641.815, + 300.67999999999984, + 87.58500000000004 + ], + "priority": 10, + "parents": [ + 90877 + ], + "children": [ + 90866, + 90876, + 90865 + ], + "area": 3839382.7356849997, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 90865, + "strid": "0cfc2a7f-0469-40be-b40e-6ef217f9148f", + "image_id": 204025, + "image_name": "121342.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1930.058, + 1793.244, + 1083.7979999999998, + 479.42899999999986 + ], + "priority": 11, + "parents": [ + 90872 + ], + "children": [], + "area": 3461064.9281519996, + "iscrowd": 0, + "segmentation": [], + "text": "The mean energy requirement when walking was\n2007 kcal/24 h (N=37), 1890 kcal/24 h when sitting in\na wheelchair (N=18) and 1837 kcal/24 h (N=10) in an\nelectric wheelchair (N=10).\n\nMean weight loss 3 months after PEG placement was\n-1.5 kg (N=48), between 3-6 months -0.8 kg (N=35),\n6-9 months -1.0 kg (N=21) and 9-12 months -0.7 kg\n(N=13)." + }, + { + "id": 90876, + "strid": "78ba3774-cf62-4fd3-bdcd-88bcc23e965d", + "image_id": 204025, + "image_name": "121342.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1938.16, + 2302.607, + 1099.34, + 1045.6019999999999 + ], + "priority": 12, + "parents": [ + 90872 + ], + "children": [], + "area": 4462820.78312, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 90866, + "strid": "aae27c23-a2df-47e6-8033-083ec6811cef", + "image_id": 204025, + "image_name": "121342.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1933.287, + 3415.675, + 1106.8970000000002, + 647.931 + ], + "priority": 13, + "parents": [ + 90872 + ], + "children": [], + "area": 6603480.073725, + "iscrowd": 0, + "segmentation": [], + "text": "The most prevalent causes of dietetical interventions\nbetween 0-3 months were loss of muscle mass and\nillness (e.g. pneumonia), 3- 6 months loss of muscle\nmass, illness and intolerance of additional (enteral)\nnutrition, 6-9 months intolerance of additional\nnutrition and loss of muscle mass, 9-12 months\nintolerance of additional nutrition.\n\nNon-invasive ventilation (NIV) (N=27) did not influence\nchanges in weight in comparison with patients\nwithout NIV." + }, + { + "id": 90874, + "strid": "b7b405c1-8ed2-4c0c-b4be-9b3fab9acca8", + "image_id": 204025, + "image_name": "121342.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 690.79, + 2689.982, + 439.04999999999995, + 84.97800000000007 + ], + "priority": 14, + "parents": [ + 90877 + ], + "children": [ + 90868 + ], + "area": 1858212.66578, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion" + }, + { + "id": 90868, + "strid": "4b5e2c84-093e-4e32-9920-77df00c32526", + "image_id": 204025, + "image_name": "121342.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 351.694, + 2838.098, + 1041.566, + 596.759 + ], + "priority": 15, + "parents": [ + 90874 + ], + "children": [], + "area": 998142.038012, + "iscrowd": 0, + "segmentation": [], + "text": "We did not notice hypermetabolism. We expected\nstabilization of weight in patients with NIV.\n\nWe also expected further weight loss after PEG\nplacement, with a difference between spinal and\nbulbar patients.\n\nNevertheless, large individual variations in weight\nchanges, also in time, were seen. It remains to be\n\nelucidated why patients could no longer tolerate\n\nadditional (enteral) nutrition." + }, + { + "id": 90875, + "strid": "85b7b0ae-dea5-4951-bcc5-f8da1550eb42", + "image_id": 204025, + "image_name": "121342.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 657.78, + 3723.063, + 501.885, + 83.3090000000002 + ], + "priority": 16, + "parents": [ + 90877 + ], + "children": [ + 90867 + ], + "area": 2448956.38014, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 90867, + "strid": "8d3225bd-9f1f-4cb5-9440-9a44abb191c4", + "image_id": 204025, + "image_name": "121342.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 354.377, + 3873.024, + 1108.382, + 170.79199999999992 + ], + "priority": 17, + "parents": [ + 90875 + ], + "children": [], + "area": 1372510.626048, + "iscrowd": 0, + "segmentation": [], + "text": "Weight loss after PEG placement can be limited due to\ndietetical evaluations and interventions, at least once\na month." + }, + { + "id": 138793, + "strid": "25e336ba-dfee-41b5-9950-1def3aabc6c5", + "image_id": 205884, + "image_name": "16536.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 2453.84, + 41.91, + 295.67999999999984, + 214.36999999999998 + ], + "priority": -1, + "parents": [], + "children": [ + 138783, + 138791, + 138779, + 138782, + 138778, + 138792, + 138780, + 138781 + ], + "area": 102840.4344, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 138778, + "strid": "844ef3db-65f7-4859-89c0-cc43275e5084", + "image_id": 205884, + "image_name": "16536.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 67.428, + 43.881, + 2295.424, + 596.965 + ], + "priority": 1, + "parents": [ + 138793 + ], + "children": [], + "area": 2958.808068, + "iscrowd": 0, + "segmentation": [], + "text": "Caver Web - Detection of Tunnels |\nand Channels in Mire poieeea ete\nand Analysis of ae he\nProcesses )" + }, + { + "id": 138779, + "strid": "ca6698fc-008c-4e12-a491-109caed68afa", + "image_id": 205884, + "image_name": "16536.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 75.595, + 726.376, + 2445.178, + 169.73699999999997 + ], + "priority": 2, + "parents": [ + 138793 + ], + "children": [], + "area": 54910.39372, + "iscrowd": 0, + "segmentation": [], + "text": "Jan Stourac*?, Ondrej Vavra*?, Piia Kokkonen’, Jiri Filipovic3, Gaspar Pinto*?, Jan Brezovsky?, Jiri Damborsky?, David Bednar*?\n*Loschmidt Laboratories, Department of Experimental Biology and RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic\n\n2International Centre for Clinical Research, St. Anne’s University Hospital Brno, Brno, Czech Republic\n\n3Institute of Computer Science, Masaryk University, Brno, Czech Republic" + }, + { + "id": 138783, + "strid": "3ca339d5-cd15-4ae3-bf47-f6904314c163", + "image_id": 205884, + "image_name": "16536.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 79.993, + 974.732, + 1550.206, + 267.44499999999994 + ], + "priority": 3, + "parents": [ + 138793 + ], + "children": [], + "area": 77971.736876, + "iscrowd": 0, + "segmentation": [], + "text": "Proteins are biomolecules responsible for a vast variety of functions in all living\norganisms. Proteins consist of one or more peptide chains forming highly\ncomplex structures containing many internal clefts, grooves, protrusions, and\nvoids. This empty space forms very important transport pathways for ligands\noften called channels and tunnels. It has been proven that the tunnels and their" + }, + { + "id": 138791, + "strid": "be2eeb1a-378f-4723-957a-413ab76f9de0", + "image_id": 205884, + "image_name": "16536.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1667.837, + 975.489, + 1549.226, + 220.54500000000007 + ], + "priority": 4, + "parents": [ + 138793 + ], + "children": [], + "area": 1626956.647293, + "iscrowd": 0, + "segmentation": [], + "text": "properties can define many important protein characteristics like substrate\nspecificity, enantioselectivity, thermal stability and/or activity. Therefore, a good\nunderstanding of these pathways is important for the deciphering of the protein\nfunction, protein engineering or drug design [1, 2]." + }, + { + "id": 138780, + "strid": "be4e630b-8c50-4555-bdef-5065306eb5b3", + "image_id": 205884, + "image_name": "16536.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 85.345, + 1351.099, + 244.16, + 60.52500000000009 + ], + "priority": 5, + "parents": [ + 138793 + ], + "children": [ + 138784, + 138787 + ], + "area": 115309.544155, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 138784, + "strid": "d8adfea3-86b1-4597-a13c-e7e20d7ce9aa", + "image_id": 205884, + "image_name": "16536.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 81.404, + 1467.941, + 1514.186, + 492.25800000000004 + ], + "priority": 6, + "parents": [ + 138780 + ], + "children": [], + "area": 119496.269164, + "iscrowd": 0, + "segmentation": [], + "text": "CAVER is a software tool for detection of tunnels and channels in the protein\nstructures and their ensembles [3]. In the first step, the Voronoi diagram\nrepresentation of the molecule is constructed and the cost for each Voronoi\nedge is calculated with respect to its width. In the second step, too narrow\nedges are filtered out and the Djikstra’s algorithm is used to find all shortest\npaths to the protein surface. In the third step, the tunnels are clustered and too\nsimilar tunnels are removed. In the last step, the characteristics like length and\nthroughput are calculated for all tunnels and their spherical representation is\nsaved." + }, + { + "id": 138787, + "strid": "533a7ce7-d1d6-475a-8a17-7335a89a3d0c", + "image_id": 205884, + "image_name": "16536.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1672.855, + 1480.282, + 1554.725, + 507.453 + ], + "priority": 7, + "parents": [ + 138780 + ], + "children": [], + "area": 2476297.14511, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 138781, + "strid": "e42e1751-a5ce-4cc8-ad17-cbb8aaedf456", + "image_id": 205884, + "image_name": "16536.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 83.619, + 2061.504, + 382.639, + 64.40599999999995 + ], + "priority": 8, + "parents": [ + 138793 + ], + "children": [ + 138788, + 138785 + ], + "area": 172380.90297599998, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 138785, + "strid": "d965d364-57d0-4452-9a30-c0d5141e80cc", + "image_id": 205884, + "image_name": "16536.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 84.065, + 2176.798, + 1536.359, + 440.68899999999985 + ], + "priority": 9, + "parents": [ + 138781 + ], + "children": [], + "area": 182992.52386999998, + "iscrowd": 0, + "segmentation": [], + "text": "CaverDock is a software tool for rapid analysis of transport processes in proteins\n[4, 5]. lt models the transportation of a ligand - a substrate, a product, an\ninhibitor, a co-factor or a co-solvent - from outside environment into the protein\nactive or binding site and vice versa. The tool employs the iterative docking\nalong the tunnel using restrained version of AutoDock Vina docking engine. The\nfirst step of the calculation is the discretization which cuts the whole tunnel to\nslices with specified distance. Next, the ligand is iteratively docked on each disk\nproducing energy profile of the transportation." + }, + { + "id": 138788, + "strid": "756946db-72c8-4da5-a36e-ee2af5c62fab", + "image_id": 205884, + "image_name": "16536.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1726.023, + 2192.225, + 1471.193, + 425.96399999999994 + ], + "priority": 10, + "parents": [ + 138781 + ], + "children": [], + "area": 3783830.7711749994, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 138782, + "strid": "9f03be05-2118-4fc9-82de-6c843412e429", + "image_id": 205884, + "image_name": "16536.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 84.139, + 2705.135, + 370.985, + 65.07900000000018 + ], + "priority": 11, + "parents": [ + 138793 + ], + "children": [ + 138789, + 138786, + 138790 + ], + "area": 227607.353765, + "iscrowd": 0, + "segmentation": [], + "text": "Caver Web" + }, + { + "id": 138786, + "strid": "5e8bd761-8d5f-4966-a278-4d307153c400", + "image_id": 205884, + "image_name": "16536.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 82.854, + 2832.347, + 1519.806, + 472.3609999999999 + ], + "priority": 12, + "parents": [ + 138782 + ], + "children": [], + "area": 234671.278338, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 138789, + "strid": "ed068eb9-5846-43a2-8c16-02f404deae42", + "image_id": 205884, + "image_name": "16536.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1710.978, + 2830.369, + 1485.5150000000003, + 1052.995 + ], + "priority": 13, + "parents": [ + 138782 + ], + "children": [], + "area": 4842699.0908820005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 138790, + "strid": "90b0cf9d-d864-4aca-aa1e-ee281499c9ff", + "image_id": 205884, + "image_name": "16536.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1697.871, + 3967.004, + 1501.48, + 83.52599999999984 + ], + "priority": 14, + "parents": [ + 138782 + ], + "children": [], + "area": 6735461.048484, + "iscrowd": 0, + "segmentation": [], + "text": "https://loschmidt.chemi.muni.cz/caverweb" + }, + { + "id": 138792, + "strid": "76c666dd-c850-4dde-bc35-f71f37e5733e", + "image_id": 205884, + "image_name": "16536.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 83.172, + 3413.731, + 1541.41, + 676.6120000000001 + ], + "priority": 15, + "parents": [ + 138793 + ], + "children": [], + "area": 283926.834732, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 124311, + "strid": "68eb26e8-2e29-4686-b984-40b001054dd6", + "image_id": 205340, + "image_name": "14797.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 286.48, + 337.79, + 162.63, + 140.44 + ], + "priority": -1, + "parents": [], + "children": [ + 124305, + 124307, + 124301, + 124310, + 124309, + 124303, + 124300, + 124298, + 124297, + 124299 + ], + "area": 96770.07920000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 124297, + "strid": "82dbca9f-c0b9-45e8-b7fc-ce34f2de1837", + "image_id": 205340, + "image_name": "14797.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 284.769, + 78.516, + 2741.1229999999996, + 49.11200000000001 + ], + "priority": 1, + "parents": [ + 124311 + ], + "children": [], + "area": 22358.922804, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 124298, + "strid": "bada115c-18fa-4bc7-b6cd-4083ef8b852d", + "image_id": 205340, + "image_name": "14797.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 828.157, + 246.79, + 1716.8159999999998, + 401.688 + ], + "priority": 2, + "parents": [ + 124311 + ], + "children": [], + "area": 204380.86603, + "iscrowd": 0, + "segmentation": [], + "text": "Natalia Szejko34, Jessica Levine', Michael H. Bloch!\n\n'Yale Child Study Center, Yale University School of Medicine, New Haven, CT\n2Yale Department of Psychiatry, Yale University School of Medicine, New Haven, CT\n3 Department of Neurology, Medical University of Warsaw, Poland\n\n4 Department of Bioethics, Medical University of Warsaw, Poland" + }, + { + "id": 124299, + "strid": "e9fa0143-2d74-4f06-8b1d-f8357bd920b8", + "image_id": 205340, + "image_name": "14797.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 97.554, + 799.593, + 1481.37, + 416.37800000000004 + ], + "priority": 3, + "parents": [ + 124311 + ], + "children": [], + "area": 78003.495522, + "iscrowd": 0, + "segmentation": [], + "text": "Background: Tourette syndrome (TS) is estimated to have a\nprevalence of 0.30-0.77% in school aged children. Longitudinal studies\nsuggest that roughly half-to-two-thirds of children with TS experience a\nsubstantial improvement in tic symptoms during adolescence. By\ncontrast, few studies have examined adulthood prevalence of TS.\nAccurate prevalence estimates across the lifespan are needed to\nsupport regulatory and public health decisions in the area." + }, + { + "id": 124301, + "strid": "3fa96bb3-ddad-41b1-b312-44d4cb511e19", + "image_id": 205340, + "image_name": "14797.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1840.453, + 807.214, + 1370.7440000000001, + 357.78200000000004 + ], + "priority": 4, + "parents": [ + 124311 + ], + "children": [], + "area": 1485639.427942, + "iscrowd": 0, + "segmentation": [], + "text": "Methods: We searched PubMED and EMBASE for studies that\nexamined the prevalence of TS in adults. We conducted a\nrandom-effects meta-analysis of logit event rates to estimate\nprevalence of TS across studies (Figure |). Too few studies are\navailable to conduct moderator analysis or examine publication\nbias." + }, + { + "id": 124300, + "strid": "f54daa67-2c1d-4266-ba67-44be642a0ba6", + "image_id": 205340, + "image_name": "14797.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 95.526, + 1371.798, + 1478.171, + 603.7349999999999 + ], + "priority": 5, + "parents": [ + 124311 + ], + "children": [], + "area": 131042.37574799999, + "iscrowd": 0, + "segmentation": [], + "text": "Results: Three studies involving 2,356,485 participants were included\n(Table |). There were significant differences in TS adulthood prevalence\nestimates between studies ranging from 49 to 657 cases of TS per\nmillion adults (Figure 2). Overall prevalence of TS in adulthood was\nestimated to be | 18 cases of TS per million adults (95%CI: 19-751 cases\nper million adults). There was a large amount of heterogeneity between\nstudies (I2=99%) that was likely related to differences in their methods\nof identification of TS cases. By contrast, the male:female ratio of risk of\nadulthood TS was similar between studies with a Risk Ratio=2.33 (95%\nCl: 1.72-3.16) (Figure 3)." + }, + { + "id": 124305, + "strid": "3eaaf5cf-a747-464b-8dba-c218db499beb", + "image_id": 205340, + "image_name": "14797.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 33.159, + 2151.562, + 1672.595, + 415.6080000000002 + ], + "priority": 6, + "parents": [ + 124311 + ], + "children": [ + 124304 + ], + "area": 71343.64435799999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 124304, + "strid": "3ef2f747-978f-41fb-93da-3359e3c0299b", + "image_id": 205340, + "image_name": "14797.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 45.232, + 2078.537, + 1220.812, + 61.68299999999999 + ], + "priority": 7, + "parents": [ + 124305 + ], + "children": [], + "area": 94016.38558399999, + "iscrowd": 0, + "segmentation": [], + "text": "are g wae ae lar Mol ele a -de om) ieee Meee)" + }, + { + "id": 124307, + "strid": "8ed35491-4128-4cc4-8428-84e20f042844", + "image_id": 205340, + "image_name": "14797.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 40.744, + 2662.834, + 1685.939, + 478.6410000000001 + ], + "priority": 8, + "parents": [ + 124311 + ], + "children": [ + 124306 + ], + "area": 108494.508496, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 124306, + "strid": "25053d6b-9158-4e77-9a26-1d790362c1f5", + "image_id": 205340, + "image_name": "14797.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 44.635, + 2591.019, + 1490.307, + 61.5 + ], + "priority": 9, + "parents": [ + 124307 + ], + "children": [], + "area": 115650.13306499999, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3: Male:Female Risk ratio of Tourette Syndrome in adults" + }, + { + "id": 124303, + "strid": "e4ef0a72-c22f-414f-9231-b5723ff13626", + "image_id": 205340, + "image_name": "14797.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1752.01, + 1481.997, + 1535.0000000000002, + 1659.97 + ], + "priority": 10, + "parents": [ + 124311 + ], + "children": [ + 124302 + ], + "area": 2596473.56397, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 124302, + "strid": "aae5d26c-b82c-4d9c-8a4a-3845ac467e58", + "image_id": 205340, + "image_name": "14797.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1753.924, + 1402.233, + 1508.442, + 63.27099999999996 + ], + "priority": 11, + "parents": [ + 124303 + ], + "children": [], + "area": 2459410.112292, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1: PRISMA Flow Chart of Articles for Selection of Studies" + }, + { + "id": 124309, + "strid": "ee585a4e-7f33-4b62-b952-7ab55d1e2e8d", + "image_id": 205340, + "image_name": "14797.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 108.974, + 3258.025, + 3005.008, + 774.0720000000001 + ], + "priority": 12, + "parents": [ + 124311 + ], + "children": [ + 124308 + ], + "area": 355040.01635000005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 124308, + "strid": "03867b2f-11b8-4b2f-b69d-6c4e41e7a03d", + "image_id": 205340, + "image_name": "14797.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 96.905, + 3177.469, + 1643.81, + 60.259000000000015 + ], + "priority": 13, + "parents": [ + 124309 + ], + "children": [], + "area": 307912.633445, + "iscrowd": 0, + "segmentation": [], + "text": "Table |: Studies Examining Prevalence of Tourette Syndrome in Adults" + }, + { + "id": 124310, + "strid": "8d2ae701-2716-4493-bb05-ed04923a266c", + "image_id": 205340, + "image_name": "14797.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 657.006, + 4204.986, + 1944.011, + 340.33799999999974 + ], + "priority": 14, + "parents": [ + 124311 + ], + "children": [], + "area": 2762701.031916, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion: Estimates of adulthood prevalence of TS are sparse and\nlikely highly affected by differences in method of case identification.\nDiagnosis and diagnostic estimates of TS could be aided by including a\nrequirement for impairment as well as potential remission criteria\nsimilar to other psychiatric conditions." + }, + { + "id": 90444, + "strid": "c72845d2-5cf9-4278-9973-8d63dab00461", + "image_id": 204010, + "image_name": "121318.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 51.59, + 61.16, + 102.16, + 178.8 + ], + "priority": -1, + "parents": [], + "children": [ + 90440, + 90435, + 90427, + 90442, + 90438, + 90420, + 90423, + 90421, + 90419, + 90430 + ], + "area": 3155.2444, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 90419, + "strid": "f3918a6d-cca0-4002-b545-7839e2038970", + "image_id": 204010, + "image_name": "121318.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 183.216, + 89.547, + 3583.387, + 200.321 + ], + "priority": 1, + "parents": [ + 90444 + ], + "children": [], + "area": 16406.443152, + "iscrowd": 0, + "segmentation": [], + "text": "Tumor Derived Stress Triggers C/EBP Homologous Protein (CHOP) Expression in\nMyeloid Derived Suppressor Cells (MDSC) and Mediates Immunosuppressive Activity" + }, + { + "id": 90420, + "strid": "6d75802b-5eec-437a-ae39-00198a530d7c", + "image_id": 204010, + "image_name": "121318.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 165.269, + 327.177, + 3609.9539999999997, + 241.47300000000007 + ], + "priority": 2, + "parents": [ + 90444 + ], + "children": [], + "area": 54072.21561300001, + "iscrowd": 0, + "segmentation": [], + "text": "Paul Thevenot!, Rosa Sierra!, Patrick Raber', Amir Al-Khami!, Jimena Trillo-Tinoco!, Parisa Zarreii', Luis Del Valle', Paulo Rodriguez!\n\nHealth Sciences Center 'Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA ree\n“ueTews“ Wepartment of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA :" + }, + { + "id": 90440, + "strid": "69b3eabb-2aa9-44e7-9e55-9bd80db34213", + "image_id": 204010, + "image_name": "121318.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 543.422, + 686.347, + 280.927, + 47.480999999999995 + ], + "priority": 3, + "parents": [ + 90444 + ], + "children": [ + 90439 + ], + "area": 372976.059434, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 90439, + "strid": "f35f8df4-c163-424f-a095-c5d46a2f03c2", + "image_id": 204010, + "image_name": "121318.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 139.598, + 764.998, + 1103.242, + 1253.444 + ], + "priority": 4, + "parents": [ + 90440 + ], + "children": [], + "area": 106792.19080400001, + "iscrowd": 0, + "segmentation": [], + "text": "Myeloid-derived suppressor cells (MDSCs) are a heterogeneous\npopulation of immature myeloid cells which accumulate in solid tumors. MDSCs\npromote tolerance and suppress anti-tumor immune responses by several\nmechanisms, including L-Arg depletion and high levels of reactive oxygen and\nnitrogen species production. The transcription factors C/EBPB and STAT3 are\ncritical to both MDSC development and suppressive function. However,\ntherapies targeting MDSC suppressive activity are limited.\n\nStress adaptation of malignant cells to the harsh conditions present\nat the tumor site is necessary to maintain survival and proliferation. Malignant\ncell adaptation is triggered by stress response pathways which alter cell\nmetabolism, cell cycle progression, antioxidant production, and promote\nrecycling of cell resources through autophagy. However, the role of stress\nresponse pathways in tumor-infiltrating stromal cells and potential effects on\nanti-tumor immune responses remain unclear.\n\nTumor-derived stress factors (hypoxia, ROS/RNS, acidification)\nbecome prominent factors as solid tumors expand. These stress factors, and the\ndepletion of essential nutrients from the tumor milieu, directly influence cell\nfunction resulting in elevated intracellular ROS, nutrient starvation, and ER\nstress. This stress is sensed by pathways of the Integrated Cell Response (ISR),\nwhich control both adaptive responses and stress-induced apoptosis. When\nadaptive responses fail to restore homeostasis, the ISR promotes\nprogrammed cell death by increasing production of C/EBP\nhomologous protein (Chop). Chop is a C/EBP transcriptional co-factor\nwhich directly promotes apoptosis through its transcriptional targets.\nAdditionally, Chop has been shown to modulate the transcriptional activity of\nC/EBPB through binding the dominant negative inhibitory C/EBPB isoform LIP\nwhich allows binding of the transcriptional active isoforms LAP and LAP*.\nSince Chop lies at critical junction which determines both cell fate\nand function, we examined the role of Chop in tumor-infiltrating\nstromal cells and as a potential central modulator of MDSC function." + }, + { + "id": 90438, + "strid": "401e0f05-472b-40e1-b1a1-54370cf21703", + "image_id": 204010, + "image_name": "121318.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 183.652, + 2071.289, + 1010.635, + 58.88099999999986 + ], + "priority": 5, + "parents": [ + 90444 + ], + "children": [ + 90437 + ], + "area": 380396.367428, + "iscrowd": 0, + "segmentation": [], + "text": "Chop Expression in Tumor-Infiltrating MDSCs" + }, + { + "id": 90437, + "strid": "97ee4caf-3baa-4fdd-8d88-81a8f8e94c69", + "image_id": 204010, + "image_name": "121318.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 107.396, + 2134.997, + 1148.668, + 519.3139999999999 + ], + "priority": 6, + "parents": [ + 90438 + ], + "children": [ + 90436 + ], + "area": 229290.13781199997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 90436, + "strid": "bc21884c-63f1-4290-8c20-d5b1d26e2421", + "image_id": 204010, + "image_name": "121318.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 109.326, + 2662.033, + 1153.495, + 100.38799999999992 + ], + "priority": 7, + "parents": [ + 90437 + ], + "children": [], + "area": 291029.41975799995, + "iscrowd": 0, + "segmentation": [], + "text": "(A) Chop expression in tumor-infiltrating stromal cell populations. (B) Chop expression\nin MDSCs recovered from the tumors or spleens of tumor-bearing mice. (C) Chop\nexpression in myeloid cells infiltrating colon adenocarinoma." + }, + { + "id": 90435, + "strid": "f21829f9-64f2-404c-ac0d-3913f511268e", + "image_id": 204010, + "image_name": "121318.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 162.079, + 2826.919, + 1055.655, + 49.5920000000001 + ], + "priority": 8, + "parents": [ + 90444 + ], + "children": [ + 90434 + ], + "area": 458184.204601, + "iscrowd": 0, + "segmentation": [], + "text": "Chop Deletion in MDSCs Delays Tumor Growth" + }, + { + "id": 90434, + "strid": "b44d42d5-9735-49ab-bfb0-a71dcebed627", + "image_id": 204010, + "image_name": "121318.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 119.603, + 2881.997, + 1142.002, + 791.4299999999998 + ], + "priority": 9, + "parents": [ + 90435 + ], + "children": [ + 90433 + ], + "area": 344695.48719099996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 90433, + "strid": "1eb2eb04-fc0c-4d5e-9986-bc2a5192148f", + "image_id": 204010, + "image_name": "121318.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 107.734, + 3678.702, + 1160.464, + 199.125 + ], + "priority": 10, + "parents": [ + 90434 + ], + "children": [], + "area": 396321.281268, + "iscrowd": 0, + "segmentation": [], + "text": "(A) Tumor growth is delayed in Chop -/- mice bearing 3LL carcinoma, B16 melanoma,\nEL4 thymoma, or MCA-38 adenocarcinoma. (B) MDSC depletion partially restores\ntumor growth in Chop -/- mice. (C) Transfer of Chop -/- bone marrow to lethally\nirradiated wild type mice delays tumor growth. (D) Transfer of wild type bone marrow\nto lethally irradiated Chop -/- mice reverses the protective effect of Chop deletion. (E)\nAdoptive transfer of Chop -/- MDSCs delays tumor growth." + }, + { + "id": 90423, + "strid": "eb70ba06-a916-4654-9dab-cb24b8b70e7a", + "image_id": 204010, + "image_name": "121318.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1378.052, + 664.489, + 1194.6789999999999, + 48.73199999999997 + ], + "priority": 11, + "parents": [ + 90444 + ], + "children": [ + 90424 + ], + "area": 915700.395428, + "iscrowd": 0, + "segmentation": [], + "text": "Effects of Chop Deletion on MDSC Accumulation and Function" + }, + { + "id": 90424, + "strid": "d054499f-3847-42ed-b780-58ea18dd9231", + "image_id": 204010, + "image_name": "121318.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1351.47, + 738.326, + 1218.307, + 694.066 + ], + "priority": 12, + "parents": [ + 90423 + ], + "children": [ + 90426 + ], + "area": 997825.4392200001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 90426, + "strid": "804a4975-aff1-4d05-a85a-9674092797e8", + "image_id": 204010, + "image_name": "121318.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1351.962, + 1454.251, + 1243.9649999999997, + 302.40599999999995 + ], + "priority": 13, + "parents": [ + 90424 + ], + "children": [], + "area": 1966092.0904619999, + "iscrowd": 0, + "segmentation": [], + "text": "(A) Increased accumulation of Chop -/- MDSCs at the tumor site. (B) Increased accumulation\nof CFSE-labeled Chop -/- MDSCs at the tumor site 24hrs after adoptive transfer to tumor-\nbearing mice. (C) Decreased apoptosis in Chop -/- MDSCs assessed by Annexin V staining and\nprotein levels of cleaved caspase-3. (D) Increased proliferation in Chop -/- MDSCs at the tumor\nsite assessed by BrdU incorporation. (E) Decreased suppression of T cell proliferation and IFNy\nproduction by Chop -/- MDSCs in vitro. (F) Expression of suppressive mediators arginase |,\niNOS, peroxynitrite, and superoxide in Chop -/- MDSCs. (G) Decreased Chop -/- MDSC\ntolerance in vivo following adoptive transfer in mice receiving TCR transgenic T cell injection\nand DC vaccination with cognate peptide." + }, + { + "id": 90427, + "strid": "0f3b4b3c-29ed-477e-bbe8-6463937ce652", + "image_id": 204010, + "image_name": "121318.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1388.517, + 1819.797, + 1176.394, + 105.23299999999995 + ], + "priority": 14, + "parents": [ + 90444 + ], + "children": [ + 90428 + ], + "area": 2526819.071049, + "iscrowd": 0, + "segmentation": [], + "text": "The Anti-Tumor Effect of Chop Deletion in MDSCs is\nCD8* T Cell Dependent" + }, + { + "id": 90428, + "strid": "39eba900-a232-4a9c-a9ea-1d855058ff52", + "image_id": 204010, + "image_name": "121318.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1353.07, + 1936.108, + 1248.396, + 655.7680000000003 + ], + "priority": 15, + "parents": [ + 90427 + ], + "children": [ + 90429 + ], + "area": 2619689.6515599997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 90429, + "strid": "4aaf4a04-bdcb-49b4-adff-51bb51c00233", + "image_id": 204010, + "image_name": "121318.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1346.424, + 2598.521, + 1252.826, + 341.17599999999993 + ], + "priority": 16, + "parents": [ + 90428 + ], + "children": [], + "area": 3498711.038904, + "iscrowd": 0, + "segmentation": [], + "text": "(A) 3LL carcinoma cytoxicity in MDSC co-culture assay. (B) Tumor growth in T cell\nimmunodeficient mice receiving WT or Chop -/- MDSC cellular therapy. (C) Increased\nintratumoral CD8* T cell accumulation, CD3¢ chain expression, and IFNy production in Chop -/-\ntumor-bearing mice. (D) Increased expression of antigen presentation complexes MHC-I and\nMHC-II in Chop -/- tumor MDSCs. (E) Increased proliferation of TCR transgenic CD8* OT-I T\ncells after co-culture with cognate peptide-loaded MDSCs measured by CFSE dilution. (F)\nTumor growth kinetics in WT or Chop -/- mice receiving depleting antibody treatments against\nCD4 or CD8 T cells. (G) Impaired growth of OVA expressing 3LL carcinoma in Chop -/- mice\nreceiving adoptive T cell immunotherapy. (H) Increased antigen specific CD8* T cell\naccumulation and IFNg production following in Chop -/- tumor-bearing mice." + }, + { + "id": 90430, + "strid": "d18e3101-489b-4a5d-9859-f1525bbeb701", + "image_id": 204010, + "image_name": "121318.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1418.425, + 2992.868, + 1113.2540000000001, + 101.90999999999985 + ], + "priority": 17, + "parents": [ + 90444 + ], + "children": [ + 90431 + ], + "area": 4245158.7929, + "iscrowd": 0, + "segmentation": [], + "text": "Chop Induction by Tumor-Derived Factors in Bone\nMarrow MDSCs" + }, + { + "id": 90431, + "strid": "0d67aaae-312a-44c7-86e5-6ce8f78721fc", + "image_id": 204010, + "image_name": "121318.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1356.393, + 3116.932, + 1229.5640000000003, + 549.4270000000001 + ], + "priority": 18, + "parents": [ + 90430 + ], + "children": [ + 90432 + ], + "area": 4227784.746276, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 90432, + "strid": "72952e04-5996-4eaf-911e-beea5d67dc12", + "image_id": 204010, + "image_name": "121318.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1351.962, + 3686.298, + 1246.1799999999998, + 168.37300000000005 + ], + "priority": 19, + "parents": [ + 90431 + ], + "children": [], + "area": 4983734.816675999, + "iscrowd": 0, + "segmentation": [], + "text": "(A) Chop induction in BM-MDSCs cultured with 3LL tumor explant supernatant (TES). (B)\nInduction of Chop by exogenous addition of tumor-derived factors to BM-MDSCs. (C) Effect of\nTES on WT and Chop -/- BM-MDSC suppressive activity. (D) Reversal of Chop induction by\nantioxidant supplementation or PNT inhibitor in BM-MDSCs. (E) Impaired Chop induction by\nTES in ATF4 +/- BM-MDSCs. (F) Impaired Chop induction by TES in gp9 I Pho -/- BM-MDSCs." + }, + { + "id": 90421, + "strid": "7a773caf-bc96-4e81-8ae8-4bb5eaa91e16", + "image_id": 204010, + "image_name": "121318.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2736.648, + 671.873, + 1033.7150000000001, + 109.27800000000002 + ], + "priority": 20, + "parents": [ + 90444 + ], + "children": [ + 90425, + 90443 + ], + "area": 1838679.9017040003, + "iscrowd": 0, + "segmentation": [], + "text": "Role of Chop in Promoting C/EBPB and STAT3\n\n \n\nActivity in MDSCs" + }, + { + "id": 90425, + "strid": "d1e310e4-27fc-4130-83fe-e188c6c2ecc6", + "image_id": 204010, + "image_name": "121318.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2685.204, + 791.018, + 1146.2959999999998, + 921.1509999999998 + ], + "priority": 21, + "parents": [ + 90421 + ], + "children": [ + 90422 + ], + "area": 2124044.697672, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 90422, + "strid": "6e2b490c-c017-4a0c-aa45-bc88b2c8a888", + "image_id": 204010, + "image_name": "121318.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2683.486, + 1715.925, + 1140.04, + 339.6490000000001 + ], + "priority": 22, + "parents": [ + 90425 + ], + "children": [], + "area": 4604660.71455, + "iscrowd": 0, + "segmentation": [], + "text": "(A) C/EBPB mRNA expression. (B) Expression of C/EBPB isoforms in MDSC nuclear\nfractions. (C) Decreased C/EBPf transcriptional activity in Chop -/- MDSCs. (D) CHIP\nassay for C/EBPf binding to IL-6 and Argl promoters in Chop -/- MDSCs. (E)\nDecreased IL-6 production and expression in Chop -/- MDSCs. (F) Decreased STAT3\nphosphorylation in Chop -/- MDSCs. (G) Decreased tumor growth with daily\nadministration of L-NAC. (H) Expression of C/EBPB isoforms. (1) Decreased Chop and\nArgl expression. (J) Decreased IL-6 Production in MDSCs. (K) Restored tumor growth\nby overexpressing IL-6 in Chop -/- mice. (L) Increased suppressive activity in Chop -/-\nMDSCs with IL-6 expressing tumors. (M) Expression of C/EBPB isoforms. (N) Restored\nSTAT3 phosphorylation and Arg! expression in Chop -/- tumor MDSCs." + }, + { + "id": 90443, + "strid": "4996f101-778e-42b6-acf6-e0b2e676eb3f", + "image_id": 204010, + "image_name": "121318.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2675.246, + 2124.746, + 1157.286, + 898.797 + ], + "priority": 23, + "parents": [ + 90421 + ], + "children": [], + "area": 5684218.237516001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 90442, + "strid": "351ea523-c5d9-45d8-9daa-78ccbc327243", + "image_id": 204010, + "image_name": "121318.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3126.491, + 3088.778, + 269.4119999999998, + 42.914999999999964 + ], + "priority": 24, + "parents": [ + 90444 + ], + "children": [ + 90441 + ], + "area": 9657036.617998, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 90441, + "strid": "19600daf-6684-4a45-b961-bc5befc18b2a", + "image_id": 204010, + "image_name": "121318.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2685.418, + 3156.727, + 1149.174, + 563.8580000000002 + ], + "priority": 25, + "parents": [ + 90442 + ], + "children": [], + "area": 8477131.506886, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178482, + "strid": "c4cc42b7-e88a-4aff-969d-94fa725907f4", + "image_id": 207466, + "image_name": "8221.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 65.72, + 355.75, + 199.59, + 103.49000000000001 + ], + "priority": -1, + "parents": [], + "children": [ + 178460, + 178473, + 178462, + 178455, + 178457, + 178459, + 178461, + 178458, + 178456 + ], + "area": 23379.89, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178455, + "strid": "834dad6a-3c20-4018-86fc-2f0e310da38a", + "image_id": 207466, + "image_name": "8221.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 532.352, + 86.334, + 2223.106, + 201.70999999999998 + ], + "priority": 1, + "parents": [ + 178482 + ], + "children": [], + "area": 45960.077568, + "iscrowd": 0, + "segmentation": [], + "text": "Can forest plant species escape the climate change fire?\nYes, by using streams as « high-speed corridors »!" + }, + { + "id": 178456, + "strid": "38cca835-5bcc-4291-a1c1-0462c9475307", + "image_id": 207466, + "image_name": "8221.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 318.856, + 316.785, + 2675.7520000000004, + 119.32800000000003 + ], + "priority": 2, + "parents": [ + 178482 + ], + "children": [], + "area": 101008.79796000001, + "iscrowd": 0, + "segmentation": [], + "text": "Guillaume Decocq, Déborah Closset-Kopp, Emilie Gallet-Moron, Emmanuelle Araujo Calcada, Jonathan Lenoir\nEDYSAN, FRE 3498 CNRS-UPJV, Jules Verne University of Picardie, 1 rue des Louvels, F-80037 Amiens Cedex 1, FRANCE, guillaume.decocq@u-picardie.fr" + }, + { + "id": 178457, + "strid": "69c025c0-676d-4b03-a7eb-5dc1640ebe58", + "image_id": 207466, + "image_name": "8221.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 115.732, + 535.537, + 264.644, + 52.07000000000005 + ], + "priority": 3, + "parents": [ + 178482 + ], + "children": [ + 178463 + ], + "area": 61978.768084, + "iscrowd": 0, + "segmentation": [], + "text": "Background" + }, + { + "id": 178463, + "strid": "921976fd-d76f-4897-9dee-6656dc0d8013", + "image_id": 207466, + "image_name": "8221.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 115.108, + 537.393, + 3090.227, + 246.49099999999999 + ], + "priority": 4, + "parents": [ + 178457 + ], + "children": [], + "area": 61858.233444000005, + "iscrowd": 0, + "segmentation": [], + "text": "Background.- Climate warming interacts with habitat fragmentation to threaten biodiversity. Ecological corridors are crucial to allow species\nmigrating towards more suitable environments, but their effectiveness often remains an open question. Metacommunity ecology provides a\nuseful framework to answer this question but so far relatively few studies have concerned plant species. Here, we evaluated the corridor\neffect of small streams originating in a large ancient forest for forest plant species within an agricultural landscape." + }, + { + "id": 178458, + "strid": "cbedf282-38ad-483e-a709-1bdd29b8f978", + "image_id": 207466, + "image_name": "8221.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 531.832, + 853.809, + 528.3160000000001, + 61.456999999999994 + ], + "priority": 5, + "parents": [ + 178482 + ], + "children": [ + 178464 + ], + "area": 454082.948088, + "iscrowd": 0, + "segmentation": [], + "text": "Research hypotheses" + }, + { + "id": 178464, + "strid": "3cf80920-b414-4eb4-8753-fc6969bb398b", + "image_id": 207466, + "image_name": "8221.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 72.218, + 920.952, + 1442.521, + 833.6670000000001 + ], + "priority": 6, + "parents": [ + 178458 + ], + "children": [], + "area": 66509.31153600001, + "iscrowd": 0, + "segmentation": [], + "text": "H1: Species richness (q-diversity) is higher in patches connected\nto the large, ancient forest than in isolated patches, since\nstreams provide the former with more immigrants, hence\nenhance colonization (mass effect) and limit local extinction\n(rescue effect).\n\nH2: Dissimilarity of species composition ((-diversity) is lower\namong connected patches than among isolated patches,\nbecause of more dispersal, hence increased homogenization of\nspecies composition.\n\nH3: More forest habitat specialists are found in connected\npatches compared to isolated ones, with a bias towards more\nhydrochores, as a result of the prominent role of streams as\necological corridors within the metacommunity." + }, + { + "id": 178460, + "strid": "01768b06-167a-4941-8f86-7697635496b7", + "image_id": 207466, + "image_name": "8221.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 511.597, + 1801.586, + 583.5539999999999, + 52.0 + ], + "priority": 7, + "parents": [ + 178482 + ], + "children": [ + 178470, + 178465, + 178478 + ], + "area": 921685.992842, + "iscrowd": 0, + "segmentation": [], + "text": "Result (H1) - a-diversity" + }, + { + "id": 178465, + "strid": "8c5ee106-882b-45b4-acdd-fb37975520b5", + "image_id": 207466, + "image_name": "8221.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 79.258, + 1858.199, + 1444.104, + 303.61900000000014 + ], + "priority": 8, + "parents": [ + 178460 + ], + "children": [], + "area": 147277.13634199998, + "iscrowd": 0, + "segmentation": [], + "text": "Ordinary least square regressions between patch type (isolated, crossed, or crossed—connected)\nand species richness (total and forest specialists), once controlled for 4 covariates: patch area,\npatch age, patch area x age, cumulative length of hedgerows\n\nZones A and B: no significant difference between crossed and crossed-\nconnected patches EXCEPT when the analysis is restricted to forest\nspecialists (zone A: P= 0.04; zone B: P= 0.06)" + }, + { + "id": 178478, + "strid": "20225da5-c648-4714-8851-fc3062edba44", + "image_id": 207466, + "image_name": "8221.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 56.831, + 2180.949, + 1470.093, + 1120.56 + ], + "priority": 9, + "parents": [ + 178460 + ], + "children": [], + "area": 123945.51261900002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178470, + "strid": "4d6c1c6f-3d0c-4288-ad0f-21fed7c361b9", + "image_id": 207466, + "image_name": "8221.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 77.379, + 3310.563, + 1418.352, + 215.70800000000008 + ], + "priority": 10, + "parents": [ + 178460 + ], + "children": [], + "area": 256168.05437700002, + "iscrowd": 0, + "segmentation": [], + "text": "Zone C and entire patch: even after accounting for the effect of patch\narea, patch type significantly explained a-diversity\n\n> mass (or rescue) effect of connectivity and dispersal on forest species\nrichness in connected patches" + }, + { + "id": 178461, + "strid": "5a3a5e48-8e36-44be-9fd5-fd3208aab024", + "image_id": 207466, + "image_name": "8221.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 508.046, + 3560.842, + 576.229, + 57.09400000000005 + ], + "priority": 11, + "parents": [ + 178482 + ], + "children": [ + 178479, + 178472, + 178471, + 178480 + ], + "area": 1809071.534732, + "iscrowd": 0, + "segmentation": [], + "text": "Result (H2) - 6-diversity" + }, + { + "id": 178471, + "strid": "8ef52363-dc50-499e-b26e-7a10ad2082e1", + "image_id": 207466, + "image_name": "8221.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 73.72, + 3629.973, + 1440.514, + 112.56800000000021 + ], + "priority": 12, + "parents": [ + 178461 + ], + "children": [], + "area": 267601.60956, + "iscrowd": 0, + "segmentation": [], + "text": "Additive partitioning of species-area relationships and subsequent split\nof f into B,,., and f,\n\narea\n\nreplace oo" + }, + { + "id": 178480, + "strid": "5b756e7a-0697-4a30-8ddd-20b998e40e3c", + "image_id": 207466, + "image_name": "8221.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 79.766, + 3762.284, + 1031.608, + 261.12199999999984 + ], + "priority": 13, + "parents": [ + 178461 + ], + "children": [], + "area": 300102.34554400004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178479, + "strid": "7d265103-baea-4fed-936b-9c95a6d98dc0", + "image_id": 207466, + "image_name": "8221.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1122.954, + 3714.403, + 407.27199999999993, + 307.69900000000007 + ], + "priority": 14, + "parents": [ + 178461 + ], + "children": [], + "area": 4171103.7064619996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178472, + "strid": "963e58e7-9330-49c7-9aae-442c53f9e203", + "image_id": 207466, + "image_name": "8221.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 77.923, + 4044.639, + 1396.254, + 159.0619999999999 + ], + "priority": 15, + "parents": [ + 178461 + ], + "children": [], + "area": 315170.404797, + "iscrowd": 0, + "segmentation": [], + "text": "Homogenizing effect on species composition only when streams come\nfrom the large, ancient forest, which extends towards upper\ntopographic levels: the spillover effect affects a@- AND (-diversity" + }, + { + "id": 178459, + "strid": "33b4c2a3-f8ee-4fb8-bb53-7cffeb2f0abf", + "image_id": 207466, + "image_name": "8221.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1656.802, + 855.382, + 295.9570000000001, + 58.402000000000044 + ], + "priority": 16, + "parents": [ + 178482 + ], + "children": [ + 178475, + 178474, + 178477, + 178476, + 178466 + ], + "area": 1417198.6083639998, + "iscrowd": 0, + "segmentation": [], + "text": "Field survey" + }, + { + "id": 178475, + "strid": "c5f0a7bb-3cb7-40c0-99cf-ffb8b89707ca", + "image_id": 207466, + "image_name": "8221.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1553.057, + 872.077, + 1721.32, + 1230.5509999999997 + ], + "priority": 17, + "parents": [ + 178459 + ], + "children": [], + "area": 1354385.289389, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178466, + "strid": "6d1d3a0d-d7cf-4ad2-9c98-8317832146b1", + "image_id": 207466, + "image_name": "8221.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1600.881, + 2129.109, + 1148.151, + 43.99400000000014 + ], + "priority": 18, + "parents": [ + 178459 + ], + "children": [], + "area": 3408450.145029, + "iscrowd": 0, + "segmentation": [], + "text": "(i) exhaustive record of all vascular plant species of the herb layer" + }, + { + "id": 178476, + "strid": "de57ae6b-13c3-492d-9639-9c7e428e563e", + "image_id": 207466, + "image_name": "8221.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1630.344, + 2166.753, + 1573.2929999999997, + 673.02 + ], + "priority": 19, + "parents": [ + 178459 + ], + "children": [], + "area": 3532552.7530320003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178474, + "strid": "d797ffda-8e36-4673-9bde-cc12982ed1b5", + "image_id": 207466, + "image_name": "8221.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1602.746, + 2807.521, + 1109.136, + 398.3589999999999 + ], + "priority": 20, + "parents": [ + 178459 + ], + "children": [], + "area": 4499743.052666001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178477, + "strid": "f58d6c2c-9daa-46e8-8b95-c92d10ef3713", + "image_id": 207466, + "image_name": "8221.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2824.36, + 2902.154, + 414.8890000000001, + 314.9290000000001 + ], + "priority": 21, + "parents": [ + 178459 + ], + "children": [], + "area": 8196727.671440001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178462, + "strid": "b962bc2f-546c-4c87-a222-ede4a8225fc9", + "image_id": 207466, + "image_name": "8221.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1996.613, + 3277.03, + 821.644, + 56.44200000000001 + ], + "priority": 22, + "parents": [ + 178482 + ], + "children": [ + 178481, + 178468, + 178467, + 178469 + ], + "area": 6542960.699390001, + "iscrowd": 0, + "segmentation": [], + "text": "Result (H3) - Species composition" + }, + { + "id": 178467, + "strid": "d9d0db0a-383d-4e89-b805-1c2dce60b85a", + "image_id": 207466, + "image_name": "8221.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1580.011, + 3342.993, + 1652.4860000000003, + 163.4380000000001 + ], + "priority": 23, + "parents": [ + 178462 + ], + "children": [], + "area": 5281965.712923, + "iscrowd": 0, + "segmentation": [], + "text": "NPMANOVA with Sgrensen index on each couple of presence/absence data\nmatrices between the 3 types of patches: species composition significantly differed\nbetween the three patch types, irrespective to the zone considered" + }, + { + "id": 178481, + "strid": "d47c20b3-2c0d-4935-90c6-18742cceb37c", + "image_id": 207466, + "image_name": "8221.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1624.404, + 3516.045, + 802.3389999999999, + 430.40099999999984 + ], + "priority": 24, + "parents": [ + 178462 + ], + "children": [], + "area": 5711477.56218, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178468, + "strid": "3a592bfe-9818-44dc-befa-5dd42625a91d", + "image_id": 207466, + "image_name": "8221.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2458.83, + 3541.856, + 763.9850000000001, + 409.96799999999985 + ], + "priority": 25, + "parents": [ + 178462 + ], + "children": [], + "area": 8708821.78848, + "iscrowd": 0, + "segmentation": [], + "text": "Indicator species analysis :\n\nIndicator species (entire patch/zone C):\nIsolated (I) : 2/3\nCrossed (C) : 1/1\nCrossed-connected (CC) : 44/29\n\nIndicator species (zone A/zone B) :\nCrossed (C) : 0/0\nCrossed-connected (CC) : 16/13" + }, + { + "id": 178469, + "strid": "75329550-4964-499d-9562-cbb6c3efe2dd", + "image_id": 207466, + "image_name": "8221.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1591.38, + 3949.997, + 1629.163, + 261.9159999999997 + ], + "priority": 26, + "parents": [ + 178462 + ], + "children": [], + "area": 6285946.225860001, + "iscrowd": 0, + "segmentation": [], + "text": "Non-parametric bootstrap : trend towards more hydrochores in crossed-\n\nconnected patches (P = 0.055)\nThe same suite of species colonizes crossed-connected patches, whilst crossed\n\nand isolated patches are rather colonized at random by species originating from\nsurrounding open lands" + }, + { + "id": 178473, + "strid": "75ef41fd-c679-4eea-a7a1-1e75f0e36bbe", + "image_id": 207466, + "image_name": "8221.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 114.053, + 4277.664, + 3074.177, + 355.2979999999998 + ], + "priority": 27, + "parents": [ + 178482 + ], + "children": [], + "area": 487880.41219199996, + "iscrowd": 0, + "segmentation": [], + "text": "Small, recent forest patches that are connected to a large, ancient forest by freshwater streams are not necessarily more\nspecies-rich (H1)... but tend to contain more forest specialists and to be more similar in species composition (H2) than\npatches missing this type of connection. They also exhibit a different species composition which tends to be biased towards a\nhigher number of hydrochores (H3). Streams are “high speed” corridors for plant species in forest meta-communities\nembedded in intensively managed agricultural landscapes: min of ca. 15.5 m yr“ instead of < 0.05 m yr?." + }, + { + "id": 51402, + "strid": "a57f9599-197a-4085-b86b-b55def4ddbc5", + "image_id": 202521, + "image_name": "118808.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 40.74, + 226.45, + 198.12, + 207.55 + ], + "priority": -1, + "parents": [], + "children": [ + 51374, + 51375, + 51377, + 51373, + 51376, + 51371, + 51372 + ], + "area": 9225.573, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 51371, + "strid": "ba33f709-756f-46b6-b753-12f41331b2c1", + "image_id": 202521, + "image_name": "118808.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 258.956, + 237.376, + 2720.472, + 223.32199999999997 + ], + "priority": 1, + "parents": [ + 51402 + ], + "children": [], + "area": 61469.93945600001, + "iscrowd": 0, + "segmentation": [], + "text": "From a geerobial gene e dene tarps to novel | agsinicrobial\n\ntargets" + }, + { + "id": 51372, + "strid": "605788e6-4ae5-4a7a-8740-1618bbcea5ae", + "image_id": 202521, + "image_name": "118808.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 86.389, + 531.47, + 3134.633, + 134.279 + ], + "priority": 2, + "parents": [ + 51402 + ], + "children": [], + "area": 45913.16183, + "iscrowd": 0, + "segmentation": [], + "text": "Fredrick M. Mobegi'”, Sacha A. F. T. van Hijum*\", Peter Burghout', Hester J. Bootsma’, Stefan P.W. de Vries', Christa Gaast-deJongh', Elles Simonetti', Jeroen Langereis', Peter W. M. Hermans', Marien de Jonge’, and Aldert Zomer'”\n\nLaboratory of Pediatric Infectious Diseases', Nijmegen Centre for Molecular Life Sciences, Centre for Molecular and Biomolecular Informatics?: Radboud University Medical Centre, Nijmegen, 6500 HB, and NIZO food reserach*, Ede, 6710 BA, the Netherlands.\n\n“Corresponding authors\n\n>. -" + }, + { + "id": 51373, + "strid": "106cebb3-b65a-4f86-8da5-82cea18965e7", + "image_id": 202521, + "image_name": "118808.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1519.918, + 757.813, + 265.672, + 55.04499999999996 + ], + "priority": 3, + "parents": [ + 51402 + ], + "children": [ + 51378 + ], + "area": 1151813.619334, + "iscrowd": 0, + "segmentation": [], + "text": "Abstract" + }, + { + "id": 51378, + "strid": "33dbb01f-5651-483b-8c1f-073e800e4070", + "image_id": 202521, + "image_name": "118808.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 92.577, + 876.678, + 3123.8949999999995, + 337.591 + ], + "priority": 4, + "parents": [ + 51373 + ], + "children": [], + "area": 81160.219206, + "iscrowd": 0, + "segmentation": [], + "text": "Respiratory tract infections, mainly caused.by Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis are among the leading causes of global\nmortality and morbidity. Increased resistance of these pathogens to existing antibiotics necessitates the search for novel targets to develop potent antimicrobials. Here,\nwe combine high-density transposon mutagenesis, high-throughput sequencing and integrative genomics, to precisely identify potential antimicrobial drug targets in\nthese human respiratory pathogens. By excluding genes having homologs in human and commensal human gut microflora, we have defined a set of 249 potential drug\ntargets, 67 of which are targeted by 75 FDA-approved antimicrobials and 35 other researched small molecule inhibitors. Four novel targets were experimentally\nvalidated. Our approach circumvents the tedious and expensive laboratory screens for drug target selection, therefore, accelerating directed drug discovery." + }, + { + "id": 51374, + "strid": "57bd4721-aa4c-438f-8935-d23ea3a267fb", + "image_id": 202521, + "image_name": "118808.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1319.591, + 1401.478, + 667.424, + 70.70499999999993 + ], + "priority": 5, + "parents": [ + 51402 + ], + "children": [ + 51399, + 51393, + 51397, + 51391, + 51401, + 51379, + 51395, + 51381, + 51398, + 51380, + 51396, + 51400, + 51392, + 51389 + ], + "area": 1849377.755498, + "iscrowd": 0, + "segmentation": [], + "text": "Approach and Results" + }, + { + "id": 51396, + "strid": "2494d83e-76e0-46f8-8cec-5255e45db928", + "image_id": 202521, + "image_name": "118808.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 149.375, + 1564.167, + 743.655, + 525.8359999999998 + ], + "priority": 6, + "parents": [ + 51374 + ], + "children": [ + 51383 + ], + "area": 233647.445625, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 51383, + "strid": "d6fbd694-bfd7-423f-84d2-299de8f7ae2d", + "image_id": 202521, + "image_name": "118808.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 116.798, + 2184.837, + 797.957, + 76.92099999999982 + ], + "priority": 7, + "parents": [ + 51396 + ], + "children": [], + "area": 255184.591926, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1 | Schematic overview of the drug targets selection\npipeline." + }, + { + "id": 51393, + "strid": "dc4caa00-156a-4be0-8e11-ee2ccadbfa4c", + "image_id": 202521, + "image_name": "118808.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 134.209, + 2352.537, + 752.0449999999998, + 447.663 + ], + "priority": 8, + "parents": [ + 51374 + ], + "children": [ + 51388 + ], + "area": 315731.638233, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 51388, + "strid": "cc292efe-5f1d-4b0a-853f-3a5cb7d237fd", + "image_id": 202521, + "image_name": "118808.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 89.584, + 2844.437, + 841.165, + 77.72200000000021 + ], + "priority": 9, + "parents": [ + 51393 + ], + "children": [], + "area": 254816.044208, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3 | Mutant libraries saturation v/s essential genes\nprediction." + }, + { + "id": 51380, + "strid": "de610b1c-6b78-4d4c-a97f-b8eacfd5f1b9", + "image_id": 202521, + "image_name": "118808.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 90.854, + 2924.907, + 842.292, + 118.29599999999982 + ], + "priority": 10, + "parents": [ + 51374 + ], + "children": [], + "area": 265739.50057800004, + "iscrowd": 0, + "segmentation": [], + "text": "The line plot shows a rarefaction analysis [2] on the mutant\nlibraries of the strains under study. Essential genes predicted\nfrom respective mutant libraries are shown in the pie chart." + }, + { + "id": 51395, + "strid": "26e89973-5392-4e90-aa3f-eb685e981689", + "image_id": 202521, + "image_name": "118808.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 126.438, + 3184.787, + 801.909, + 332.12599999999975 + ], + "priority": 11, + "parents": [ + 51374 + ], + "children": [ + 51394 + ], + "area": 402678.09870599996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 51394, + "strid": "79363a53-ec31-4bfa-a0cc-885bc2f096ca", + "image_id": 202521, + "image_name": "118808.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 158.891, + 3578.006, + 762.239, + 78.45499999999993 + ], + "priority": 12, + "parents": [ + 51395 + ], + "children": [], + "area": 568512.951346, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 4 | Conservation of essential genes among\nrespiratory pathogens." + }, + { + "id": 51381, + "strid": "9eda43e7-269e-4252-b117-4056b99edeb5", + "image_id": 202521, + "image_name": "118808.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 160.918, + 3659.886, + 724.464, + 38.38200000000006 + ], + "priority": 13, + "parents": [ + 51374 + ], + "children": [], + "area": 588941.535348, + "iscrowd": 0, + "segmentation": [], + "text": "OGs with(a), and without (b) singletones respectively." + }, + { + "id": 51397, + "strid": "a8b14fe2-8644-449b-aea9-9d31b9bcb9b6", + "image_id": 202521, + "image_name": "118808.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1014.588, + 1519.46, + 1203.8010000000002, + 336.509 + ], + "priority": 14, + "parents": [ + 51374 + ], + "children": [ + 51384 + ], + "area": 1541625.88248, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 51384, + "strid": "c3efa67d-9788-4703-b282-c23be9f44b53", + "image_id": 202521, + "image_name": "118808.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1006.922, + 1957.348, + 1085.429, + 36.968000000000075 + ], + "priority": 15, + "parents": [ + 51397 + ], + "children": [], + "area": 1970896.762856, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2 | Overview of genes essentiality prediction using Tn-seq technique." + }, + { + "id": 51379, + "strid": "2c9a68a2-c62f-4d26-a238-fd35c144df0f", + "image_id": 202521, + "image_name": "118808.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1006.724, + 1995.056, + 1222.1419999999998, + 268.9789999999998 + ], + "priority": 16, + "parents": [ + 51374 + ], + "children": [], + "area": 2008470.7565440002, + "iscrowd": 0, + "segmentation": [], + "text": "Bacterial mutant libraries constructed by in vitro mariner transposon mutagenesis are\ncultured. Mutants of genes essential for growth are lost. To identify these genes, Tn-Seq [1,\n2,3]; a next-generation sequencing method able to rapidly identify transposon insertion\nsites, is used. The number of sequence reads per transposon mutant is compared to the\nexpected number of reads based on number of insertion sites present in the gene, as a\nmeasure for the essentiality of the gene. ESSENTIALS[3]; a web-tool developed in-house\nwas used to implemented this technique." + }, + { + "id": 51391, + "strid": "cbbb55b8-b567-4afa-8d80-93bc437817e5", + "image_id": 202521, + "image_name": "118808.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2296.912, + 1501.222, + 863.6210000000001, + 658.702 + ], + "priority": 17, + "parents": [ + 51374 + ], + "children": [ + 51385 + ], + "area": 3448174.8264639997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 51385, + "strid": "8a1578d3-a387-4cc0-8f0f-d37391b210d3", + "image_id": 202521, + "image_name": "118808.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2290.415, + 2200.885, + 872.7330000000002, + 71.0909999999999 + ], + "priority": 18, + "parents": [ + 51391 + ], + "children": [], + "area": 5040940.017275, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1 | Summary of the strains studied; their genome annotation\nupdates and respective essentiality predictions. _" + }, + { + "id": 51398, + "strid": "1b1c6b21-5716-46b3-b889-4b70669fd68e", + "image_id": 202521, + "image_name": "118808.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1013.955, + 2359.284, + 745.6339999999999, + 547.6120000000001 + ], + "priority": 19, + "parents": [ + 51374 + ], + "children": [ + 51387 + ], + "area": 2392207.80822, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 51387, + "strid": "a9cb5d8b-2540-4b7e-a86a-88b61f3c9b86", + "image_id": 202521, + "image_name": "118808.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1002.729, + 3524.184, + 857.8999999999999, + 40.13599999999997 + ], + "priority": 20, + "parents": [ + 51398 + ], + "children": [], + "area": 3533801.4981360002, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 5 | Validation of inhibition in disk diffusion assays:" + }, + { + "id": 51401, + "strid": "57af27ed-1b18-4202-b2f3-7978ae3c6e93", + "image_id": 202521, + "image_name": "118808.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1011.883, + 2947.605, + 744.904, + 471.1210000000001 + ], + "priority": 21, + "parents": [ + 51374 + ], + "children": [], + "area": 2982631.390215, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 51399, + "strid": "68a4ad36-4e60-4263-9591-4c99258291aa", + "image_id": 202521, + "image_name": "118808.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1792.749, + 2357.958, + 696.5730000000001, + 443.7370000000001 + ], + "priority": 22, + "parents": [ + 51374 + ], + "children": [], + "area": 4227226.846542, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 51400, + "strid": "4ac8e73f-3c3b-4977-a1f1-c55a7a373347", + "image_id": 202521, + "image_name": "118808.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2523.67, + 2359.376, + 693.9360000000001, + 439.90599999999995 + ], + "priority": 23, + "parents": [ + 51374 + ], + "children": [], + "area": 5954286.429920001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 51392, + "strid": "61141b7a-8e07-49b2-b403-c99892c98e80", + "image_id": 202521, + "image_name": "118808.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1824.506, + 2904.087, + 1402.22, + 291.06399999999985 + ], + "priority": 24, + "parents": [ + 51374 + ], + "children": [ + 51386 + ], + "area": 5298524.156022, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 51386, + "strid": "de06457e-3273-407e-8d11-3b884413c42a", + "image_id": 202521, + "image_name": "118808.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1825.358, + 3296.034, + 1383.2259999999999, + 82.5659999999998 + ], + "priority": 25, + "parents": [ + 51392 + ], + "children": [], + "area": 6016442.030172, + "iscrowd": 0, + "segmentation": [], + "text": "Table 2 | Drug targets validation toxicity essays. Std. Dev. = Standard deviation; *= Delayed growth;\n*Area of inhibition measured in the disc diffusion assay." + }, + { + "id": 51389, + "strid": "4e44878c-73d4-4fb7-95df-c07e9154b7eb", + "image_id": 202521, + "image_name": "118808.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1004.857, + 3568.292, + 1673.9409999999998, + 167.88099999999986 + ], + "priority": 26, + "parents": [ + 51374 + ], + "children": [], + "area": 3585623.1942439997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 51375, + "strid": "edd3a119-6c82-4647-a0db-6fe85388a664", + "image_id": 202521, + "image_name": "118808.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1273.765, + 3797.458, + 779.9750000000001, + 59.58100000000013 + ], + "priority": 27, + "parents": [ + 51402 + ], + "children": [ + 51382 + ], + "area": 4837069.08937, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 51382, + "strid": "6aa3b9c1-f75b-4bef-87ca-5236a6cb3ad0", + "image_id": 202521, + "image_name": "118808.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 98.879, + 3875.893, + 3121.663, + 327.4960000000001 + ], + "priority": 28, + "parents": [ + 51375 + ], + "children": [], + "area": 383244.423947, + "iscrowd": 0, + "segmentation": [], + "text": "We have combined Tn-seq with in silico approaches to obtain an insight into many essential and conserved molecular functions, which we predicted to be unique among\nrespiratory pathogens but absent in human and commensal human gut microbiota[5]. With this combinational approach, we have reliably identified various potential drug targets\nin in the five strains, including key enzymes in pathways such as fatty acid biosynthesis, vitamin biosynthesis, and isoprenoids biosynthesis pathways, which have gained interest\nin drug discovery research, as well as known targets inhibited by clinically beneficial drugs. In conclusion, we have pioneered a powerful approach, which combines gene\nessentiality datasets with robust computational techniques, to comprehensively screen for antimicrobial drug targets at genome-scale. This approach circumvents the complex\n\nand costly laboratory screens, thus, facilitating directed drugs discovery. —_" + }, + { + "id": 51377, + "strid": "69b98638-eb7e-4319-b48c-199412ffcc9b", + "image_id": 202521, + "image_name": "118808.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2123.963, + 4253.748, + 245.72899999999981, + 66.97800000000007 + ], + "priority": 29, + "parents": [ + 51402 + ], + "children": [], + "area": 9034803.363324, + "iscrowd": 0, + "segmentation": [], + "text": "Funding" + }, + { + "id": 51376, + "strid": "f1040984-f635-4b5a-b5cd-c4d3dbacf209", + "image_id": 202521, + "image_name": "118808.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 700.271, + 4251.178, + 301.322, + 54.02000000000044 + ], + "priority": 30, + "parents": [ + 51402 + ], + "children": [ + 51390 + ], + "area": 2976976.6692379997, + "iscrowd": 0, + "segmentation": [], + "text": "Literature" + }, + { + "id": 51390, + "strid": "5dc82590-75ea-425c-927d-01aff5595f09", + "image_id": 202521, + "image_name": "118808.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 102.144, + 4345.505, + 1420.106, + 211.3069999999998 + ], + "priority": 31, + "parents": [ + 51376 + ], + "children": [], + "area": 443867.26272000006, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 48072, + "strid": "f491c422-f09f-45df-af50-5f6ce8433a0e", + "image_id": 202382, + "image_name": "118622.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 100.75, + 121.76, + 122.24000000000001, + 146.69 + ], + "priority": -1, + "parents": [], + "children": [ + 48070, + 48055, + 48071, + 48050, + 48056, + 48052, + 48054, + 48053, + 48051 + ], + "area": 12267.32, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 48050, + "strid": "eed94a48-a9e4-4ec2-876f-a05520935a14", + "image_id": 202382, + "image_name": "118622.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 267.603, + 98.037, + 3977.2969999999996, + 407.721 + ], + "priority": 1, + "parents": [ + 48072 + ], + "children": [], + "area": 26234.995311000002, + "iscrowd": 0, + "segmentation": [], + "text": "CHARACTERISTICS, SYMPTOMS AND TREAPMENT INTERVENTIONS\n\nFOR PATIENTS AT A PAIN CLINIC\n- A PROSPECTIVE STUDY WITH A THREE MONTHS FOLLOW UP" + }, + { + "id": 48051, + "strid": "96ae7e1e-c114-4e18-b32b-dd551586def1", + "image_id": 202382, + "image_name": "118622.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 271.651, + 554.124, + 2400.581, + 55.42399999999998 + ], + "priority": 2, + "parents": [ + 48072 + ], + "children": [], + "area": 150528.338724, + "iscrowd": 0, + "segmentation": [], + "text": "Andrea Haltstam RN, Monika Lofgren PT PhD, Christér’Svensén MD PhD Prof., Britt-Marie Stalnacké MD PhD" + }, + { + "id": 48052, + "strid": "fa654678-faad-4173-aae9-6e80c8c6bdfe", + "image_id": 202382, + "image_name": "118622.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 93.97, + 832.374, + 474.726, + 73.81899999999996 + ], + "priority": 3, + "parents": [ + 48072 + ], + "children": [ + 48057 + ], + "area": 78218.18478, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 48057, + "strid": "8e88843b-1d44-4a43-ab78-4dee8b8e0981", + "image_id": 202382, + "image_name": "118622.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 90.21, + 946.428, + 1444.923, + 354.68899999999996 + ], + "priority": 4, + "parents": [ + 48052 + ], + "children": [], + "area": 85377.26987999999, + "iscrowd": 0, + "segmentation": [], + "text": "A follow-up after three months showed that patients\nwith severe chronic pain treated with either Basic Pain\nTreatment (BPT) or a Multimodal Rehabilitation pro-\ngram (MMR) at an outpatient pain clinic, might improve\nhealth-related quality of life (HRQoL) and insomnia." + }, + { + "id": 48053, + "strid": "e4a01811-a2ac-433c-a9f4-3bc5989dc15c", + "image_id": 202382, + "image_name": "118622.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 95.221, + 1420.928, + 527.665, + 74.05799999999999 + ], + "priority": 5, + "parents": [ + 48072 + ], + "children": [ + 48058 + ], + "area": 135302.18508800003, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 48058, + "strid": "51f52771-8b1b-437c-b194-796129d1ba86", + "image_id": 202382, + "image_name": "118622.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 92.17, + 1534.152, + 1400.973, + 575.0630000000001 + ], + "priority": 6, + "parents": [ + 48053 + ], + "children": [], + "area": 141402.78984, + "iscrowd": 0, + "segmentation": [], + "text": "Chronic pain is a major problem for the individual\nand the society. Despite improvements in treatment,\nchallenge remains for health care to improve quality\nof life for these patients. Patients with severe chronic\npain are normally treated at pain clinics, but the\noutcome of pharmacological, psychological,\neducational treatment and physical training\nprograms Is still debatable." + }, + { + "id": 48054, + "strid": "4dcbad2f-68d7-4cb7-905e-97b95fd57757", + "image_id": 202382, + "image_name": "118622.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 90.085, + 2215.619, + 169.298, + 72.97600000000011 + ], + "priority": 7, + "parents": [ + 48072 + ], + "children": [ + 48059 + ], + "area": 199594.037615, + "iscrowd": 0, + "segmentation": [], + "text": "Aim" + }, + { + "id": 48059, + "strid": "f0fbe82b-5a71-40f8-bb21-144f0c63993e", + "image_id": 202382, + "image_name": "118622.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 90.241, + 2316.654, + 1425.611, + 279.951 + ], + "priority": 8, + "parents": [ + 48054 + ], + "children": [], + "area": 209057.173614, + "iscrowd": 0, + "segmentation": [], + "text": "To describe characteristics for patients with chronic\npain treated at a pain clinic and the impact of different\ntreatment interventions concerning symptoms and\nquality of life after a three month follow-up period." + }, + { + "id": 48055, + "strid": "23e4ec0f-0568-40fe-a657-8d8e5d264017", + "image_id": 202382, + "image_name": "118622.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 93.847, + 2729.188, + 319.898, + 75.37199999999984 + ], + "priority": 9, + "parents": [ + 48072 + ], + "children": [ + 48061, + 48060, + 48064, + 48062 + ], + "area": 256126.106236, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 48060, + "strid": "98edaa80-309d-4675-9640-9b0a909b29e0", + "image_id": 202382, + "image_name": "118622.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 92.081, + 2844.003, + 1439.051, + 500.7049999999999 + ], + "priority": 10, + "parents": [ + 48055 + ], + "children": [], + "area": 261878.64024300003, + "iscrowd": 0, + "segmentation": [], + "text": "Prospective observational study at a Swedish out-\npatient pain clinic. Two treatment groups were\nfollowed. Patients were placed into different treatment\ngroups based on their specific needs. Patients with\ncomplex pain problems and readiness for\n\nbehavior change received individually adapted MMR.\nBPT was the other treatment option (Figure’)." + }, + { + "id": 48061, + "strid": "621799d1-ae2c-43b9-9077-499d452918af", + "image_id": 202382, + "image_name": "118622.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1645.305, + 951.275, + 1401.4950000000001, + 418.34900000000005 + ], + "priority": 11, + "parents": [ + 48055 + ], + "children": [], + "area": 1565137.513875, + "iscrowd": 0, + "segmentation": [], + "text": "The pain clinic team consisted of a physician,\n\nnurses, physiotherapists, a psychologist and an\noccupational therapist. BPT implied contact with\n\none or two members of the team, while MMR implied\na comprehensive multi-modal rehabilitation program\nfor about 12 weeks." + }, + { + "id": 48062, + "strid": "36c1f0a5-a991-480c-b426-4f740154f84c", + "image_id": 202382, + "image_name": "118622.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1640.727, + 1506.291, + 1445.9580000000003, + 364.2639999999999 + ], + "priority": 12, + "parents": [ + 48055 + ], + "children": [ + 48063 + ], + "area": 2471412.313557, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 48063, + "strid": "d873a6a9-0f92-4dfe-b4a6-4fc8619dea93", + "image_id": 202382, + "image_name": "118622.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1639.22, + 1942.981, + 1215.93, + 41.541999999999916 + ], + "priority": 13, + "parents": [ + 48062 + ], + "children": [], + "area": 3184973.31482, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1: Flowchart of patients assessment and treatment process" + }, + { + "id": 48064, + "strid": "c685c00f-d7f3-42a7-bf82-b69752f00fee", + "image_id": 202382, + "image_name": "118622.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1641.985, + 2141.898, + 1387.139, + 1209.991 + ], + "priority": 14, + "parents": [ + 48055 + ], + "children": [], + "area": 3516964.38753, + "iscrowd": 0, + "segmentation": [], + "text": "Inclusion criteria for the study; newly admittance to\nthe pain clinic, pain >3 months and age >18 years.\nExclusion criteria; severe illness with expected\nsurvival less than 6 months and inability to complete\nthe questionnaire.\n\nIncluded patients: 139 patients (82 female) were in\nthe BPT group and 18 (16 female] in the MMR.\nMedian age was 52 [21-84] in the BPT and 43 (22-60)\nin the MMR.\n\nQuestionnaires used: Health related quality of life;\nEQ-5D™) anxiety and depression; Hospital Anxiety\nand Depression Scale (HADS)”, insomnia; Insomnia\nSeverity Index, (ISI ]*! and pain: Visual Analog rating\nScale (VAS)4!," + }, + { + "id": 48056, + "strid": "7c9d647b-fccf-4eff-a244-1cb3fdcacb10", + "image_id": 202382, + "image_name": "118622.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3206.116, + 832.861, + 325.85599999999977, + 75.42600000000004 + ], + "priority": 15, + "parents": [ + 48072 + ], + "children": [ + 48068, + 48067, + 48066 + ], + "area": 2670248.977876, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 48066, + "strid": "627c5933-75fe-41e7-aca8-88686d001703", + "image_id": 202382, + "image_name": "118622.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 3201.153, + 1081.343, + 1457.4360000000001, + 838.1699999999998 + ], + "priority": 16, + "parents": [ + 48056 + ], + "children": [ + 48065 + ], + "area": 3461544.388479, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 48065, + "strid": "6b416234-bc84-4105-b5e3-e34dd7e77a2b", + "image_id": 202382, + "image_name": "118622.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 3199.628, + 963.081, + 1310.4479999999999, + 85.09399999999994 + ], + "priority": 17, + "parents": [ + 48066 + ], + "children": [], + "area": 3081500.9338680003, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1. HRQoL and symptoms before treatment and at follow-up in BPT\nand MMR" + }, + { + "id": 48068, + "strid": "63e02e4f-ddac-41d0-9984-ec1bf44d1607", + "image_id": 202382, + "image_name": "118622.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3225.185, + 1953.525, + 1125.1240000000003, + 71.95000000000005 + ], + "priority": 18, + "parents": [ + 48056 + ], + "children": [], + "area": 6300479.527125, + "iscrowd": 0, + "segmentation": [], + "text": "md = median. Wilcoxon signed rank test was used for significance estimation.\nP-values < 0. 05 are considered to be significant." + }, + { + "id": 48067, + "strid": "eaa1eca0-8165-47bd-9b99-3adbce08b604", + "image_id": 202382, + "image_name": "118622.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 3200.711, + 2266.509, + 1457.8119999999994, + 682.4629999999997 + ], + "priority": 19, + "parents": [ + 48056 + ], + "children": [ + 48069 + ], + "area": 7254440.287899, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 48069, + "strid": "7c677c6c-68f5-4895-863f-2ee2562f440d", + "image_id": 202382, + "image_name": "118622.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 3198.732, + 2151.088, + 1353.496, + 91.50300000000016 + ], + "priority": 20, + "parents": [ + 48067 + ], + "children": [], + "area": 6880754.020416001, + "iscrowd": 0, + "segmentation": [], + "text": "Table 2: Changes in HRQoL, anxiety, depression and insomnia from before\ntreatment to three months follow-up in BPT and MMR." + }, + { + "id": 48071, + "strid": "32b9d171-ed62-4b2d-aae7-f5a5b501839a", + "image_id": 202382, + "image_name": "118622.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3225.257, + 3150.89, + 1391.547, + 159.63200000000006 + ], + "priority": 21, + "parents": [ + 48072 + ], + "children": [], + "area": 10162430.02873, + "iscrowd": 0, + "segmentation": [], + "text": "The study is part ofa PhD-project, where patients’ experiences\nof pain treatment are explored with a qualitative method app<\nroach as well." + }, + { + "id": 48070, + "strid": "8571e168-1eab-4fac-9433-c528789aeedc", + "image_id": 202382, + "image_name": "118622.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3236.479, + 3516.005, + 1294.2490000000003, + 358.37300000000005 + ], + "priority": 22, + "parents": [ + 48072 + ], + "children": [], + "area": 11379476.346394999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 119576, + "strid": "af69f769-467b-48fb-98ff-b54a1f57f72c", + "image_id": 205153, + "image_name": "14368.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 36.1, + 58.28, + 191.56, + 172.41 + ], + "priority": -1, + "parents": [], + "children": [ + 119561, + 119560, + 119563, + 119556, + 119572, + 119557, + 119555 + ], + "area": 2103.908, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 119555, + "strid": "28bc4884-c40c-4c94-8831-7b7c1caeed1f", + "image_id": 205153, + "image_name": "14368.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 294.561, + 85.592, + 2255.191, + 173.413 + ], + "priority": 1, + "parents": [ + 119576 + ], + "children": [], + "area": 25212.065111999997, + "iscrowd": 0, + "segmentation": [], + "text": "Multi-disciplinary medication review: for safer, patient centered\nprescribing." + }, + { + "id": 119556, + "strid": "dabfb3d6-5846-40a4-9f46-7bef4cce381e", + "image_id": 205153, + "image_name": "14368.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 372.874, + 332.166, + 2070.4530000000004, + 115.50299999999999 + ], + "priority": 2, + "parents": [ + 119576 + ], + "children": [], + "area": 123856.065084, + "iscrowd": 0, + "segmentation": [], + "text": "Dr Khalifa Boukadida, Dr Sanjeev Vasishta, Mrs Denise owen, Mrs L.Pietrzak-jones, Mrs M.Khalaf\nGwanwyn ward, St Woolos Hospital, Aneurin Bevan Health Board. Wales. UK" + }, + { + "id": 119557, + "strid": "df1a49d5-4123-4cb8-ad30-dd417940cdcd", + "image_id": 205153, + "image_name": "14368.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 107.23, + 641.237, + 242.45999999999998, + 45.639999999999986 + ], + "priority": 3, + "parents": [ + 119576 + ], + "children": [ + 119558 + ], + "area": 68759.84351, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 119558, + "strid": "14ec8769-cbb0-48db-854f-29b77d82d528", + "image_id": 205153, + "image_name": "14368.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 121.583, + 735.287, + 2528.345, + 434.8620000000001 + ], + "priority": 4, + "parents": [ + 119557 + ], + "children": [], + "area": 89398.399321, + "iscrowd": 0, + "segmentation": [], + "text": "Potentially inappropriate prescribing(PIP) in the context of poly-pharmacy is a key issue in the pharmacotherapy of older age group\nand can inevitably lead to adverse drug events ( ADE’s)\n\nPreventing adverse drug events (ADEs) is a major priority for NHS and regulatory agencies.\n\n5-17% of hospital admissions are medicine related, and once in hospital 6-17% of older people suffers from adverse drug reaction\nduring their stay.\n\nMost of our patients had multiple co-morbidities and they were prescribed 5 or more medications.\n\nWe had an increased number of incidents reports related to drugs errors and omissions." + }, + { + "id": 119560, + "strid": "a362c092-5fa2-451e-aac1-f485e5fa4d82", + "image_id": 205153, + "image_name": "14368.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 112.463, + 1248.472, + 359.395, + 57.62699999999995 + ], + "priority": 5, + "parents": [ + 119576 + ], + "children": [ + 119559 + ], + "area": 140406.906536, + "iscrowd": 0, + "segmentation": [], + "text": "Intervention:" + }, + { + "id": 119559, + "strid": "8f40a1d8-57a6-4348-b9dd-8f87c917a2a8", + "image_id": 205153, + "image_name": "14368.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 106.951, + 1335.091, + 1862.822, + 217.85500000000002 + ], + "priority": 6, + "parents": [ + 119560 + ], + "children": [], + "area": 142789.31754099997, + "iscrowd": 0, + "segmentation": [], + "text": "We organised weekly multidisciplinary ward rounds focusing on patients at risk of polypharmacy.\nProject team involved Pharmacists, Senior doctors and senior nurses.\nProcess involved detailed review of drug charts.\n\nWe used STOPP criteria as a guidance for medication review." + }, + { + "id": 119561, + "strid": "86e7f723-d14b-4a9d-85c4-e9152bd5ffa3", + "image_id": 205153, + "image_name": "14368.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 107.302, + 1619.443, + 556.181, + 62.38799999999992 + ], + "priority": 7, + "parents": [ + 119576 + ], + "children": [ + 119562 + ], + "area": 173769.472786, + "iscrowd": 0, + "segmentation": [], + "text": "Strategy for change:" + }, + { + "id": 119562, + "strid": "4535d5bf-f438-4c46-b08e-c2e26f27c28b", + "image_id": 205153, + "image_name": "14368.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 120.347, + 1702.067, + 2073.338, + 227.06099999999992 + ], + "priority": 8, + "parents": [ + 119561 + ], + "children": [], + "area": 204838.65724899998, + "iscrowd": 0, + "segmentation": [], + "text": "To introduce the culture of MDT medication review.\n\nTo Communicate our strategy locally across the health board.\n\nTo improve communication between primary and secondary care.\n\nTo develop the culture of shared decision making with patients and their carers on reviewing medications." + }, + { + "id": 119563, + "strid": "45281195-767b-4f44-a9ee-606a2a2ed5a0", + "image_id": 205153, + "image_name": "14368.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 105.732, + 1989.679, + 862.325, + 64.72699999999986 + ], + "priority": 9, + "parents": [ + 119576 + ], + "children": [ + 119565, + 119568, + 119566, + 119570, + 119564, + 119567, + 119569 + ], + "area": 210372.740028, + "iscrowd": 0, + "segmentation": [], + "text": "Measurement of improvement:" + }, + { + "id": 119564, + "strid": "8dc182f3-408d-48a1-b9f8-b0495135dc05", + "image_id": 205153, + "image_name": "14368.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 121.957, + 2088.019, + 1409.8470000000002, + 502.99000000000024 + ], + "priority": 10, + "parents": [ + 119563 + ], + "children": [], + "area": 254648.53318299996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 119565, + "strid": "8c5662d8-cd57-472a-892f-3a990a14b114", + "image_id": 205153, + "image_name": "14368.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 109.907, + 2712.111, + 542.868, + 102.30999999999995 + ], + "priority": 11, + "parents": [ + 119563 + ], + "children": [], + "area": 298079.983677, + "iscrowd": 0, + "segmentation": [], + "text": "Process output:\nFollowing our intervention:" + }, + { + "id": 119566, + "strid": "2c74540f-fb02-47b3-95bf-06a79d1e8d6e", + "image_id": 205153, + "image_name": "14368.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 114.083, + 2822.772, + 1421.897, + 396.71100000000024 + ], + "priority": 12, + "parents": [ + 119563 + ], + "children": [], + "area": 322030.298076, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 119567, + "strid": "277d0d2f-6630-4149-a549-ee8280de456e", + "image_id": 205153, + "image_name": "14368.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 118.259, + 3273.77, + 1392.665, + 398.799 + ], + "priority": 13, + "parents": [ + 119563 + ], + "children": [], + "area": 387152.76643, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 119568, + "strid": "585b4255-5d95-4e05-ba42-5aeb2b5d464f", + "image_id": 205153, + "image_name": "14368.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1561.731, + 2259.025, + 1440.6879999999999, + 428.03099999999995 + ], + "priority": 14, + "parents": [ + 119563 + ], + "children": [ + 119575 + ], + "area": 3527989.372275, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 119575, + "strid": "efef8036-90c8-4af7-a672-55ab2803c7e4", + "image_id": 205153, + "image_name": "14368.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1970.309, + 2120.048, + 641.2639999999999, + 35.3119999999999 + ], + "priority": 15, + "parents": [ + 119568 + ], + "children": [], + "area": 4177149.6548319994, + "iscrowd": 0, + "segmentation": [], + "text": "Fig1: multiple co-morbidities affecting our patients" + }, + { + "id": 119569, + "strid": "c7f19993-4f71-480f-87d9-12107dea07c8", + "image_id": 205153, + "image_name": "14368.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1584.67, + 2930.224, + 1352.909, + 594.7829999999999 + ], + "priority": 16, + "parents": [ + 119563 + ], + "children": [ + 119574 + ], + "area": 4643438.06608, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 119574, + "strid": 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0, + "segmentation": [], + "text": "Multidisciplinary medication review should be imbedded in our practice to promote prudent prescribing and ensure a safe pathway\npreventing drug errors between a clinician's decision to prescribe a medication and the patient actually receiving it." + }, + { + "id": 25092, + "strid": "b8ac0466-c504-4a24-bf51-e263f86531df", + "image_id": 201503, + "image_name": "117221.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 5109.61, + 371.88, + 161.73000000000047, + 161.73000000000002 + ], + "priority": -1, + "parents": [], + "children": [ + 25073, + 25061, + 25059, + 25063, + 25062, + 25074, + 25066, + 25064, + 25065, + 25058, + 25060 + ], + "area": 1900161.7667999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 25058, + "strid": "59ffe598-4358-408e-8146-97ab4f429223", + "image_id": 201503, + "image_name": "117221.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 59.081, + 27.027, + 4778.378, + 324.324 + ], + 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the left side of the plus\nsign and the poster, but the head is on the right side of\nthe object." + }, + { + "id": 25068, + "strid": "dc4fc0d0-d173-482e-827f-0428327d92be", + "image_id": 201503, + "image_name": "117221.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 65.597, + 1264.829, + 1242.16, + 563.644 + ], + "priority": 6, + "parents": [ + 25060 + ], + "children": [], + "area": 82968.98791299999, + "iscrowd": 0, + "segmentation": [], + "text": "Do we utilize object-based spatial\nrepresentations for the parts of objects (as\nopposed to general spatial representations)?\n\nHow are any object-based spatial\nrepresentations related to more general\nspatial representations?" + }, + { + "id": 25065, + "strid": "ecfd7bee-14fd-46ce-af8a-4da02b2e33b0", + "image_id": 201503, + "image_name": "117221.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 69.011, + 1993.98, + 701.881, + 76.83800000000019 + ], + "priority": 7, + "parents": [ + 25092 + ], + "children": [ + 25071, + 25070, + 25069, + 25089, + 25090 + ], + "area": 137606.55378, + "iscrowd": 0, + "segmentation": [], + "text": "Case study: Patient JKI" + }, + { + "id": 25069, + "strid": "16a49f9e-c7f9-4484-87e6-70447eed38a5", + "image_id": 201503, + "image_name": "117221.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 67.422, + 2111.566, + 704.398, + 282.8539999999998 + ], + "priority": 8, + "parents": [ + 25065 + ], + "children": [], + "area": 142366.00285199998, + "iscrowd": 0, + "segmentation": [], + "text": "50 yr. old male. A stroke in\n2003 led to bilateral parietal\nlobe damage and some occipital\nlobe damage." + }, + { + "id": 25090, + "strid": "f87547eb-f45d-492f-9f0b-6ff38481a3a8", + "image_id": 201503, + "image_name": "117221.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 826.64, + 1938.811, + 394.58399999999995, + 506.06999999999994 + ], + "priority": 9, + "parents": [ + 25065 + ], + "children": [], + "area": 1602698.72504, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 25070, + "strid": "355f02a2-a857-4a94-a919-47d12ae7bcb5", + "image_id": 201503, + "image_name": "117221.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 83.846, + 2521.305, + 1230.042, + 318.38200000000006 + ], + "priority": 10, + "parents": [ + 25065 + ], + "children": [], + "area": 211401.33903, + "iscrowd": 0, + "segmentation": [], + "text": "Case History\nVisual field defect\n\nJKI has a lower visual field defect, especially on the left\n(so all testing is of the upper visual field)." + }, + { + "id": 25089, + "strid": "64d4e467-5907-4c41-847c-a74828cbfcfd", + "image_id": 201503, + "image_name": "117221.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 87.32, + 2888.33, + 1120.375, + 353.4850000000001 + ], + "priority": 11, + "parents": [ + 25065 + ], + "children": [], + "area": 252208.97559999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 25071, + "strid": "db3bc124-7163-4795-95a0-3cd770fdef8f", + "image_id": 201503, + "image_name": "117221.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 77.455, + 3307.301, + 1190.71, + 207.35300000000007 + ], + "priority": 12, + "parents": [ + 25065 + ], + "children": [], + "area": 256166.998955, + "iscrowd": 0, + "segmentation": [], + "text": "JKI also has simultanagnosia, affecting the LVF. When\nshown a display like the one on top, he will tend to\nreport seeing only the rightmost object." + }, + { + "id": 25061, + "strid": "6cfcb551-4c19-439d-829e-ff0b2dea7d54", + "image_id": 201503, + "image_name": "117221.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1390.477, + 511.958, + 1517.5470000000003, + 163.52000000000004 + ], + "priority": 13, + "parents": [ + 25092 + ], + "children": [ + 25080, + 25084 + ], + "area": 711865.8239660001, + "iscrowd": 0, + "segmentation": [], + "text": "SYSTEMATIC MIS-LOCALIZATION OF LEFT VISUAL\nFIELD OBJECTS (w/no deficit in the RVF)" + }, + { + "id": 25084, + "strid": "85f1aaa7-82c1-438b-b6c9-dc67ee2d5a3a", + "image_id": 201503, + "image_name": "117221.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1466.848, + 723.885, + 1251.0429999999997, + 227.20399999999995 + ], + "priority": 14, + "parents": [ + 25061 + ], + "children": [], + "area": 1061829.26448, + "iscrowd": 0, + "segmentation": [] + }, + 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+ "strid": "4db664d8-9f99-4046-9fca-b233b53c100a", + "image_id": 201503, + "image_name": "117221.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1459.021, + 3020.176, + 1510.6379999999997, + 486.8000000000002 + ], + "priority": 20, + "parents": [ + 25066 + ], + "children": [], + "area": 4406500.207696, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 25062, + "strid": "23a25735-e736-4c7f-a06b-2f7dfe1e6726", + "image_id": 201503, + "image_name": "117221.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3027.673, + 511.958, + 1958.254, + 69.79500000000002 + ], + "priority": 21, + "parents": [ + 25092 + ], + "children": [ + 25085, + 25082, + 25081, + 25086 + ], + "area": 1550041.413734, + "iscrowd": 0, + "segmentation": [], + "text": "HORIZONTAL MIS-LOCALIZATION OF FEATURES\n\nW/IN AN OBJECT" + }, + { + "id": 25085, + "strid": "b1094cfd-bed9-4f88-9caa-9acfd7e100b0", + "image_id": 201503, + "image_name": "117221.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3053.577, + 616.852, + 768.7780000000002, + 271.68899999999996 + ], + "priority": 22, + "parents": [ + 25062 + ], + "children": [], + "area": 1883605.079604, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 25082, + "strid": "ed3dd7ee-3902-4a1f-b005-7121b3eb49a1", + "image_id": 201503, + "image_name": "117221.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3050.127, + 926.374, + 976.0390000000002, + 292.615 + ], + "priority": 23, + "parents": [ + 25062 + ], + "children": [], + "area": 2825558.349498, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 25081, + "strid": "2271eede-3df5-4479-9b7e-0377df68ea83", + "image_id": 201503, + "image_name": "117221.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3054.055, + 1319.146, + 1598.5840000000003, + 135.50600000000009 + ], + "priority": 24, + "parents": [ + 25062 + ], + "children": [], + "area": 4028744.4370299997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 25086, + "strid": "dd221525-8d06-4f86-a463-cb53c235fcdd", + "image_id": 201503, + "image_name": "117221.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 4373.783, + 628.927, + 1018.3289999999997, + 772.803 + ], + "priority": 25, + "parents": [ + 25062 + ], + "children": [], + "area": 2750790.2208410003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 25073, + "strid": "a460487f-aed9-4497-9fa7-5cbd8719dd57", + "image_id": 201503, + "image_name": "117221.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3082.216, + 1562.312, + 523.1749999999997, + 66.00099999999998 + ], + "priority": 26, + "parents": [ + 25092 + ], + "children": [ + 25075 + ], + "area": 4815383.043392, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 25075, + "strid": "dcdccf2a-8b4f-4d6c-9a44-e60726c32839", + "image_id": 201503, + "image_name": "117221.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3082.353, + 1672.591, + 845.7539999999999, + 782.201 + ], + "priority": 27, + "parents": [ + 25073 + ], + "children": [], + "area": 5155515.886623, + "iscrowd": 0, + "segmentation": [], + "text": "That JKI’s w/in object deficit\nPIGS eT eS\ngeneralhobject deficit does not,\nsuggests specialized\nrepresentations of relative\nCSC MSU EE TELS LA Ld\nthe deficits suggests shared\nCHIEU Lm ler Pee]\nHOME cr TAT RUC" + }, + { + "id": 25074, + "strid": "232ccdbb-3915-4eaf-a3c6-d076821b02df", + "image_id": 201503, + "image_name": "117221.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4043.248, + 1562.312, + 368.63700000000017, + 67.6099999999999 + ], + "priority": 28, + "parents": [ + 25092 + ], + "children": [ + 25077, + 25076 + ], + "area": 6316814.869376, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 25076, + "strid": "43231ba2-d315-4606-b5cc-87bdc67474e2", + "image_id": 201503, + "image_name": "117221.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 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+ { + "id": 25072, + "strid": "3da0e53c-779e-40a3-9c6c-45d85bc66cc9", + "image_id": 201503, + "image_name": "117221.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3050.289, + 2816.772, + 946.837, + 305.8409999999999 + ], + "priority": 32, + "parents": [ + 25063 + ], + "children": [], + "area": 8591968.647108, + "iscrowd": 0, + "segmentation": [], + "text": "Task: report 3 features of a rectangle’s notch\n\nJKI again reported the shape, horizontal,\nand vertical position of notches within\nrectangles." + }, + { + "id": 25078, + "strid": "59ec2d0b-d597-46df-b0db-cc71abd11bb6", + "image_id": 201503, + "image_name": "117221.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3060.625, + 3225.186, + 1127.9610000000002, + 196.76899999999978 + ], + "priority": 33, + "parents": [ + 25063 + ], + "children": [], + "area": 9871084.901250001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 25087, + "strid": "2cd09bf6-cf08-4392-a4db-c09e55f5f32b", + 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[ + 131732 + ], + "children": [], + "area": 58564.615076, + "iscrowd": 0, + "segmentation": [], + "text": "MINDING YOUR NEIGHBORS: A SPATIAL\nANALYSIS OF SOUTH CAROLINA RESIDENTS’\nPERCEPTION TOWARDS CONSERVATION" + }, + { + "id": 131710, + "strid": "d978761a-d5b1-4b25-89e4-a1f1bdc54d33", + "image_id": 205613, + "image_name": "15418.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1899.764, + 374.723, + 1020.8689999999999, + 65.803 + ], + "priority": 2, + "parents": [ + 131732 + ], + "children": [], + "area": 711885.2653719999, + "iscrowd": 0, + "segmentation": [], + "text": "Julie Carl Ureta; Marzieh Motallebi" + }, + { + "id": 131711, + "strid": "a5d21973-c05e-4456-b146-a248217ed2f5", + "image_id": 205613, + "image_name": "15418.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 275.161, + 531.381, + 409.79800000000006, + 56.33100000000002 + ], + "priority": 3, + "parents": [ + 131732 + ], + "children": [ + 131715 + ], + "area": 146215.327341, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 131715, + "strid": "89682dd8-355a-462d-8d56-c228da2b771f", + "image_id": 205613, + "image_name": "15418.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 241.185, + 661.089, + 1452.8, + 1107.8760000000002 + ], + "priority": 4, + "parents": [ + 131711 + ], + "children": [], + "area": 159444.75046500002, + "iscrowd": 0, + "segmentation": [], + "text": "Increasing economic pressure brought by urbanization and continuously increasing population has brought significant impact\nto the overall state of the environment. Most often, this results to rapid decline of pristine ecosystem and degradation due to\nextraction of natural resources. Hence, robust and effective policies on natural resources conservation are of utmost\nimportance to ensure consideration of societal welfare. One of the widely used technique in understanding social perspective\nis by eliciting stakeholders’ perception towards a certain issue. This provide researchers and policy makers specific focus.\nThis study, as preliminary for developing a “Payments for Ecosystem Services” scheme, conducted a survey to elicit the\nperception of 1500 South Carolina residents towards conservation. The objective is to elicit the priority ecosystem service of\nthe residents to come up with a focused design for developing the PES. The analysis was also broken down to a county level\nassessment to find out if there is a “neighbor's effect” towards their preference. The study used a Rank analysis to determine\nthe priority ecosystem and ecosystem services, logistic regression model for analyzing the factors that affect their\n\nprioritization, and spatial regression models to understand if there is a “neighbor's effect” towards their responses.\n\nThe results showed that water-related ecosystem service, particularly good water quality, is the priority ecosystem service by\nthe residents. The regression model showed that this prioritization has something to do with: familiarity to natural resource\nconservation concept, professional education of the respondents, income level, and number of household members.\nFurthermore, the spatial lag model also suggests that the neighboring counties’ characteristics has an effect to the average\nrating of another county's satisfaction and perception, hence ultimately to their decision making process. Subsequently, the\nsecondary ecosystem service that residents prioritize is the abundance of water. This is interesting since many of the policies\nand water management plans focuses on abundance of water rather than on its quality. The results from this study could be\n\nused as an argument to consider adjustments to policies towards water management." + }, + { + "id": 131712, + "strid": "19a6541c-185e-4ec2-9ce7-38797597bcd8", + "image_id": 205613, + "image_name": "15418.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 278.601, + 1828.663, + 422.49799999999993, + 70.8789999999999 + ], + "priority": 5, + "parents": [ + 131732 + ], + "children": [ + 131729, + 131723, + 131716, + 131717, + 131720, + 131722, + 131719 + ], + "area": 509467.340463, + "iscrowd": 0, + "segmentation": [], + "text": "Methodology" + }, + { + "id": 131716, + "strid": "92ced8b2-0b84-498d-a014-94230c17bc02", + "image_id": 205613, + "image_name": "15418.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 238.903, + 1930.665, + 324.765, + 292.8850000000002 + ], + "priority": 6, + "parents": [ + 131712 + ], + "children": [], + "area": 461241.66049499996, + "iscrowd": 0, + "segmentation": [], + "text": "Focus Group Discussion\nwith the story map of\nConversation on\nEcosystem Services\nValuation and Payments\nfor Ecosystem\n\nServices." + }, + { + "id": 131719, + "strid": "3b00759f-d503-4caf-a48f-455c9e41f6d0", + "image_id": 205613, + "image_name": "15418.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 567.543, + 1940.592, + 354.05499999999995, + 350.46000000000004 + ], + "priority": 7, + "parents": [ + 131712 + ], + "children": [], + "area": 1101369.405456, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 131717, + "strid": "75f6883e-efeb-4e5a-9aa8-ea5e3a3787cf", + "image_id": 205613, + "image_name": "15418.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 944.918, + 1927.253, + 341.7210000000001, + 299.05799999999977 + ], + "priority": 8, + "parents": [ + 131712 + ], + "children": [], + "area": 1821096.050254, + "iscrowd": 0, + "segmentation": [], + "text": "We conducted an online\nsurvey of 1555 South\nCarolina residents\n\nto elicit their preference in\nterms of the priority\necosystem and\necosystem services." + }, + { + "id": 131720, + "strid": "d782f2b0-16e8-41a6-9385-61f9c000c056", + "image_id": 205613, + "image_name": "15418.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1341.183, + 1933.98, + 314.36300000000006, + 346.0859999999998 + ], + "priority": 9, + "parents": [ + 131712 + ], + "children": [], + "area": 2593821.09834, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 131729, + "strid": "11a476a2-f8ea-47a0-a799-1c41f0411c88", + "image_id": 205613, + "image_name": "15418.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 235.887, + 2308.89, + 1478.151, + 1255.634 + ], + "priority": 10, + "parents": [ + 131712 + ], + "children": [], + "area": 544637.13543, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 131723, + "strid": "a1da9639-002d-4268-a0fb-0c1c9ea39d76", + "image_id": 205613, + "image_name": "15418.png", + "category_id": 3, + "category_name": "Text", + 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0, + "segmentation": [], + "text": "South Carolina residents\nprioritize water-related\necosystem services and forest\necosystem. This can be a sound\nbasis for designing a PES\nframework.\n\nLikelihood regression results\nreveal that satisfaction rating to\nthe current environmental\ncharacteristics affect their\nprioritization of preferred\necosystem and ecosystem\nservices.\n\nSince there is statistical evidence\nthat factors affecting mean\nsatisfaction rating of counties are\naffected by neighboring counties’\nrating and factors, these effects\nare worth considering for future\nplanning and implementation of\nconservation programs and\npolicies.\n\nFurthermore, holistic\nconservation planning should\ninclude consideration of\nbiophysical, geographic, social,\n\nand economic characteristics of\nstakeholders.\n\nInvolvement of the stakeholders\nin conservation planning is a key\ncomponent for targeting priority\nareas and appropriately\naddressing the main concerns of\nthe society.\n\nProvided an appropriate targeting\nof ecosystem and ecosystem\nservices, a PES program in SC is\ntimely and feasible." + }, + { + "id": 82197, + "strid": "84b82460-df8f-479a-acb8-2927a6934ab0", + "image_id": 203696, + "image_name": "120764.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 472.77, + 493.67, + 451.78, + 120.82 + ], + "priority": -1, + "parents": [], + "children": [ + 82169, + 82170, + 82167, + 82174, + 82173, + 82168, + 82176, + 82175, + 82177, + 82172, + 82171 + ], + "area": 233392.3659, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 82167, + "strid": "49bc6ebe-9ea0-48b7-b46c-91ffb5dec1e1", + "image_id": 203696, + "image_name": "120764.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 64.923, + 70.382, + 5448.904, + 132.439 + ], + "priority": 1, + "parents": [ + 82197 + ], + "children": [], + "area": 4569.410586000001, + "iscrowd": 0, + "segmentation": [], + "text": "Developing a Pilot Indicator System for U.S. Climate Changes, Impacts, Vulnerabilities, and Responses" + }, + { + "id": 82168, + "strid": "3f74558e-7a4b-4d77-87d7-04641218c376", + "image_id": 203696, + "image_name": "120764.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1107.262, + 233.401, + 4395.315, + 337.854 + ], + "priority": 2, + "parents": [ + 82197 + ], + "children": [], + "area": 258436.058062, + "iscrowd": 0, + "segmentation": [], + "text": "Melissa A. Kenney!”, Anthony C. Janetos?, Derek Arndt’, Richard V. Pouyat’, Rebecca J. Aicher®, Ainsley Lloyd!?, Omar Malik?2,\nJulian Reyes”, Sarah Anderson®\n\nTEarth System Science Interdisciplinary Center/Cooperative Institute for Climate and Satellites-Maryland, University of Maryland, College.Park, MD; 2U.S. Global Change Research Program, Washington, DC; >The Frederick S. Pardee Center forthe\nStudy of the Longer-Range Future, Boston University, Boston, MA; “National Climatic Data Center, National Oceanic and Atmospheric Administration, Asheville, NC; °U.S. Forest Service, ‘U:S) Department of Agriculture, Arlington, VA; °Office of\nResearch and Development, U.S»Environmental Protection Agency, Crystal City, VA; 7Department of Civil and Environmental Engineering, Washington State University (WSU), Pullman,;WA; ®School of Biological Sciences, WSU, Pullman,WA" + }, + { + "id": 82169, + "strid": "a82a488f-f8d3-4ec9-a871-ad9cbaf74a09", + "image_id": 203696, + "image_name": "120764.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 61.806, + 685.139, + 1184.341, + 66.83900000000006 + ], + "priority": 3, + "parents": [ + 82197 + ], + "children": [ + 82196, + 82178 + ], + "area": 42345.701034, + "iscrowd": 0, + "segmentation": [], + "text": "Background: National Climate Assessment" + }, + { + "id": 82178, + "strid": "322fb6a0-a17c-4b4f-8ee6-e3b0cff721ed", + "image_id": 203696, + "image_name": "120764.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 55.117, + 763.039, + 1790.071, + 444.702 + ], + "priority": 4, + "parents": [ + 82169 + ], + "children": [], + "area": 42056.420563, + "iscrowd": 0, + "segmentation": [], + "text": "The National Climate Assessment (NCA), a component of the U.S. Global Change Research\nProgram (USGCRP)yis designed to produce periodic scientific assessments of the vulnerability\nof important sectors in the U.S. to climate change and variability, and to report on response\nstrategies forresponding to and coping with change. An important feature of the NCA is to\ndevelop climate-relevant information for use by a wide variety of users in the public and\nprivate sectors and in the scientific community. The development of a national system of\n\nindicators is an essential feature of this information system and provides a foundation for\nassessing change on an ongoing basis." + }, + { + "id": 82196, + "strid": "6ab91833-56e9-41ab-b482-dc0cfe5a3902", + "image_id": 203696, + "image_name": "120764.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 190.338, + 1251.976, + 1546.127, + 172.54899999999998 + ], + "priority": 5, + "parents": [ + 82169 + ], + "children": [], + "area": 238298.60788800003, + "iscrowd": 0, + "segmentation": [], + "text": "Indicators consist of long-term measurements or calculations that capture\nimportant features of the status, trend, or performance of sectors of interest\n(e.g. the economy, agriculture, oceans, forests)." + }, + { + "id": 82177, + "strid": "d4d00125-e4b9-4a4c-87c1-4cc585e96dc7", + "image_id": 203696, + "image_name": "120764.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 57.56, + 1528.316, + 1077.499, + 65.96900000000005 + ], + "priority": 6, + "parents": [ + 82197 + ], + "children": [ + 82179, + 82180, + 82193 + ], + "area": 87969.86896, + "iscrowd": 0, + "segmentation": [], + "text": "The National Climatelndicator System" + }, + { + "id": 82179, + "strid": "192decd1-5672-4311-8dd7-450654a05332", + "image_id": 203696, + "image_name": "120764.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 56.862, + 1603.71, + 1815.029, + 612.5720000000001 + ], + "priority": 7, + "parents": [ + 82177 + ], + "children": [], + "area": 91190.15802, + "iscrowd": 0, + "segmentation": [], + "text": "The USGCRP, their associated federal agencies, and the Indicator Work Group are leading an\neffort to identify a first Set of physical, ecological, and societal indicators that would inform\ndecision-makers andthe public about our nation’s changing climate. Over 150 scientists and\npractitioners have been in conversations to develop the scientific basis for the selection of\nindicators using.conceptual models and the recommendations*of\\indicators, including those\nthat alreadyexist as well as new indicators, which link to these conceptual models.\n\nThe system is designed to include the decision-relevant.climate changes, impacts,\nvulnerabilities and preparedness, including those aspects that occur in a multi-stressor\ncontext. These components serve as categoriesywithin which to organize an end-to-end system\nof indicators:\n\nTae" + }, + { + "id": 82193, + "strid": "dd25a6af-41c2-41d9-b38a-4e702af0fc77", + "image_id": 203696, + "image_name": "120764.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 186.539, + 2200.486, + 1001.8689999999999, + 516.837 + ], + "priority": 8, + "parents": [ + 82177 + ], + "children": [], + "area": 410476.4579539999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 82180, + "strid": "04c8bde7-fa25-4d47-9585-7aa10d1fc495", + "image_id": 203696, + "image_name": "120764.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1269.79, + 2247.696, + 579.413, + 462.4830000000002 + ], + "priority": 9, + "parents": [ + 82177 + ], + "children": [], + "area": 2854101.90384, + "iscrowd": 0, + "segmentation": [], + "text": "Categories of Indicators:\nFramework for the National\nClimate Indicator System. Physical,\necological, and societal.indicators\ncould fall into different-categories of\nthis end-to-end, framework. The\nframework includes the linkages\nbetween sources and sinks to\nimpacts ‘to*responses, which over\ntime can impact sources and sinks." + }, + { + "id": 82176, + "strid": "6981674c-574e-4410-a076-217cf14ac53d", + "image_id": 203696, + "image_name": "120764.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 62.126, + 2792.959, + 686.961, + 54.534999999999854 + ], + "priority": 10, + "parents": [ + 82197 + ], + "children": [ + 82194 + ], + "area": 173515.37083399997, + "iscrowd": 0, + "segmentation": [], + "text": "Milestones and Timeline" + }, + { + "id": 82194, + "strid": "e5e81412-f88f-4653-b06e-02fb83c61ece", + "image_id": 203696, + "image_name": "120764.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 231.597, + 2877.675, + 1452.445, + 659.9610000000002 + ], + "priority": 11, + "parents": [ + 82176 + ], + "children": [], + "area": 666460.896975, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 82170, + "strid": "aa556b75-6b90-4a66-b604-fa488168d025", + "image_id": 203696, + "image_name": "120764.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1969.025, + 686.047, + 592.5750000000003, + 66.95000000000005 + ], + "priority": 12, + "parents": [ + 82197 + ], + "children": [ + 82188, + 82189, + 82191, + 82192 + ], + "area": 1350843.694175, + "iscrowd": 0, + "segmentation": [], + "text": "Identifying Indicators" + }, + { + "id": 82189, + "strid": "c63ff75d-6122-43c0-b88a-f121897d871a", + "image_id": 203696, + "image_name": "120764.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1963.217, + 784.482, + 1736.6569999999997, + 443.1779999999999 + ], + "priority": 13, + "parents": [ + 82170 + ], + "children": [], + "area": 1540108.398594, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 82188, + "strid": "87a867ba-ef3e-4a49-a942-eace5e502152", + "image_id": 203696, + "image_name": "120764.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1963.025, + 1257.802, + 1710.1690000000003, + 577.712 + ], + "priority": 14, + "parents": [ + 82170 + ], + "children": [], + "area": 2469096.77105, + "iscrowd": 0, + "segmentation": [], + "text": "Several technical teams of experts have.been formed to cover different sectors and\nsystems and to ensure considerationof*key indicators across the physical, ecological, and\nsocietal contexts. These groups cover-the following systems/sectors: agriculture, climate,\nenergy, forests, freshwater ecosystems, grasslands, health, infrastructure, mitigation and\ngreenhouse gases, oceans and coasts, phenology, and water cycle.\n\nThe teams are identifying indicators within their area of expertise through the\ndevelopment of conceptual models that encapsulate the climate and non-climate drivers\nof their system andthe indicators that they have identified. An overseeing body (the\nIndicator Work Group) will use these recommendations to identify indicators for a pilot\nsystem, the initial indicator system, and development of research priorities." + }, + { + "id": 82192, + "strid": "20545d92-e3de-4c4e-b3c0-79dbeced797d", + "image_id": 203696, + "image_name": "120764.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2000.525, + 1885.909, + 1119.812, + 821.0729999999999 + ], + "priority": 15, + "parents": [ + 82170 + ], + "children": [], + "area": 3772808.1022250005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 82191, + "strid": "a556b641-109a-4c38-89a4-eed7559210c0", + "image_id": 203696, + "image_name": "120764.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3130.673, + 1889.867, + 578.8559999999998, + 740.5049999999999 + ], + "priority": 16, + "parents": [ + 82170 + ], + "children": [], + "area": 5916555.590491, + "iscrowd": 0, + "segmentation": [], + "text": "Example Draft Technical Team\nConceptual Models. The Health\nTechnical Team Conceptual Model\ndescribes how a given indicator may\nbe affected by different drivers from\nboth within the system and external\nto the system; it is customizable to\neach indicator recommended. Their\ndraft conceptual model serves as an\nexample of the systems, framework\nand utility of indicators for\nunderstanding key aspects of their\nspecific system. The conceptual\nmodels also illustrates how their\nsector relates-to and is impacted by\nthe larger climate system." + }, + { + "id": 82175, + "strid": "17045908-f9e8-460d-b7f6-b81f414b2811", + "image_id": 203696, + "image_name": "120764.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1967.784, + 2789.75, + 1064.397, + 67.23599999999988 + ], + "priority": 17, + "parents": [ + 82197 + ], + "children": [ + 82181 + ], + "area": 5489625.414, + "iscrowd": 0, + "segmentation": [], + "text": "Purpose of the Pilot Indicators System" + }, + { + "id": 82181, + "strid": "dfde416c-d6de-4faf-b993-3f97e37e0eeb", + "image_id": 203696, + "image_name": "120764.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1964.388, + 2884.702, + 1738.239, + 657.9479999999999 + ], + "priority": 18, + "parents": [ + 82175 + ], + "children": [], + "area": 5666673.992376001, + "iscrowd": 0, + "segmentation": [], + "text": "The purpose of the pilot indicator system is to provide’an example that will allow us to\nengage with stakeholder communities to build outthe kind of indicator system that would\nbe most useful to support decision-making. The information that we collect from this\nengagement and the data from surveys and focus groups will be used to enhance users’\nexperiences and improve the utility of the indicators for decision support.\n\nThe pilot additionally serves as a proof-of concept to the Federal agencies and the USGGRP.\nIt will be implemented on a website and the metadata will be available on the Global\nChange Information System (GCIS).\n\nOver the next year we willbe learning from the pilot phase to build out the indicator\nsystem, given the vision, to support adaptation and mitigation decisions. Modifications of\nwebsite design andindicator customizations will be informed by stakeholder needs." + }, + { + "id": 82171, + "strid": "05ef8da6-6adb-4926-ae60-3b1fc856fef9", + "image_id": 203696, + "image_name": "120764.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3805.255, + 681.842, + 425.3590000000004, + 55.11299999999994 + ], + "priority": 19, + "parents": [ + 82197 + ], + "children": [ + 82187, + 82185, + 82195, + 82186 + ], + "area": 2594582.67971, + "iscrowd": 0, + "segmentation": [], + "text": "Pilot Indicators" + }, + { + "id": 82186, + "strid": "8e489f56-1008-4747-9813-411b38e376c2", + "image_id": 203696, + "image_name": "120764.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3800.538, + 766.8, + 1653.2099999999996, + 222.60500000000002 + ], + "priority": 20, + "parents": [ + 82171 + ], + "children": [], + "area": 2914252.5384, + "iscrowd": 0, + "segmentation": [], + "text": "A set of pilot indicators were recommended and selected for those that required no\nadditional research, data analysis or transformation, and/or sophisticated visual\ndevelopment. These recommendations were justified by the(téam’s conceptual model\nand implemented through collaborations with the Indicator-Team and technical team" + }, + { + "id": 82187, + "strid": "cdc655be-7f42-48aa-a46c-f56119f791fa", + "image_id": 203696, + "image_name": "120764.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3804.99, + 999.793, + 155.82299999999987, + 41.553 + ], + "priority": 21, + "parents": [ + 82171 + ], + "children": [], + "area": 3804202.3670699997, + "iscrowd": 0, + "segmentation": [], + "text": "experts." + }, + { + "id": 82195, + "strid": "5f41aa7e-d601-44b6-9ca8-10433b4834a4", + "image_id": 203696, + "image_name": "120764.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3806.419, + 1108.06, + 1176.9250000000002, + 645.258 + ], + "priority": 22, + "parents": [ + 82171 + ], + "children": [], + "area": 4217740.637139999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 82185, + "strid": "c46574dc-1f08-45bc-98c7-e49ea5d7f668", + "image_id": 203696, + "image_name": "120764.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 5004.087, + 1013.149, + 541.6710000000003, + 838.477 + ], + "priority": 23, + "parents": [ + 82171 + ], + "children": [], + "area": 5069885.739963001, + "iscrowd": 0, + "segmentation": [], + "text": "Example Draft Potential Growing\nSeason Anomalies Pilot\nIndicator: The potential growing\nseason, defined by the number of\nfrost-free days in a given year,\nencompasses the length of time\nfor active plant growth and soil\ndecomposition. During the past\n30 years, there has been.an\nincrease in the length ofthe\npotential growing.season across\nAlaska and thefcontiguous U.S.\nwhen compared to the average\nover that same time period. The\nindicator‘can be used for\nagricultural planning and natural\nresource and wildfire\nmanagement." + }, + { + "id": 82172, + "strid": "33a15bd8-069d-477f-baf6-16b855135211", + "image_id": 203696, + "image_name": "120764.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3801.89, + 1922.783, + 992.5719999999997, + 66.0909999999999 + ], + "priority": 24, + "parents": [ + 82197 + ], + "children": [ + 82190, + 82184 + ], + "area": 7310209.459869999, + "iscrowd": 0, + "segmentation": [], + "text": "Evaluation of Pilot Indicator System" + }, + { + "id": 82184, + "strid": "43bac693-b3f8-4cea-bbba-1b6f04180004", + "image_id": 203696, + "image_name": "120764.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3797.57, + 2000.029, + 1717.024, + 103.88200000000006 + ], + "priority": 25, + "parents": [ + 82172 + ], + "children": [], + "area": 7595250.1295300005, + "iscrowd": 0, + "segmentation": [], + "text": "The’pilot indicator system is designed to work with*potential users of the indicator system\nand we have developed a number of scientificallyrigorous evaluation studies, including:" + }, + { + "id": 82190, + "strid": "26dbd7b5-07e7-484f-9ff6-a03f447e24e4", + "image_id": 203696, + "image_name": "120764.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3924.371, + 2110.49, + 1613.438, + 278.4870000000001 + ], + "priority": 26, + "parents": [ + 82172 + ], + "children": [], + "area": 8282345.751789999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 82173, + "strid": "61a747d2-39e1-4e28-ae31-80468a4cebcd", + "image_id": 203696, + "image_name": "120764.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3810.835, + 2451.419, + 522.2060000000001, + 62.559999999999945 + ], + "priority": 27, + "parents": [ + 82197 + ], + "children": [ + 82183 + ], + "area": 9341953.324865, + "iscrowd": 0, + "segmentation": [], + "text": "How to Participate" + }, + { + "id": 82183, + "strid": "3f7d3465-4740-4cba-9a16-0a8d05022553", + "image_id": 203696, + "image_name": "120764.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3807.958, + 2525.376, + 1720.806, + 217.38599999999997 + ], + "priority": 28, + "parents": [ + 82173 + ], + "children": [], + "area": 9616525.742208, + "iscrowd": 0, + "segmentation": [], + "text": "The scientific communityyand the public are invited to discuss needs for.specific indicators\nand to provide descriptions and supporting information for considération in the indicator\nsystem. There-are also opportunities for science policy interns and fellows to work with\nthe Indicators.feam; please contact us if you are interested." + }, + { + "id": 82174, + "strid": "a98e9136-885b-43ad-8e9f-2e776c12888b", + "image_id": 203696, + "image_name": "120764.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3799.539, + 3063.99, + 555.2239999999997, + 66.03600000000006 + ], + "priority": 29, + "parents": [ + 82197 + ], + "children": [ + 82182 + ], + "area": 11641749.50061, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements" + }, + { + "id": 82182, + "strid": "f57444df-bbbd-4336-9f78-9e38e9d9e147", + "image_id": 203696, + "image_name": "120764.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3800.36, + 3136.263, + 1734.0009999999997, + 397.66100000000006 + ], + "priority": 30, + "parents": [ + 82174 + ], + "children": [], + "area": 11918928.45468, + "iscrowd": 0, + "segmentation": [], + "text": "This study was partially supported by NOAA grant NAO9NES4400006 (Cooperative Institute for Climate and Satellites -CICS) at the University of\nMaryland/ESSIC. The authors additionally wish to acknowledge support of the USGCRP, National Oceanic and Atmospheric Administration (NOAA),\nNational Aeronautics and Space Administration (NASA), Environmental Protection Agency (EPA), Department of Interior (DOI) U.S. Geological Survey\n(USGS), U.S. Department of Agriculture (USDA) U.S. Forest Service (USFS), Department of Energy (DOE), Centers for Disease Control (CDC), Army Corps of\nEngineers (USACE), and National Science Foundation (NSF). This work was developed in collaboration with the National Climate Assessment\nDevelopment and Advisory Committee, Indicator'Work Group. The technical team leads are: Derek Arndt (Climate and Water, NOAA), Britta Bierwagen\n(Freshwater Ecosystems, EPA), Nancy Cavallaro (Grasslands, USDA), Leon Clarke (Greenhouse Gases and Mitigation; DOE JGCRI), Roger Griffis (Oceans and\nCoasts, NOAA), Patricia Gober (Adaptation and Hazards, Arizona State University), Jerry Hatfield (Agriculture; USDA), Linda Heath (Forests, USFS), Michael\nMcGeehin (Health), Laurie Mcgilvray (Oceansvand Coasts, NOAA), Dennis Ojima (Grasslands, Colorado State University), Kathleen Tierney (Adaptation and\nHazards, University of Colorado, Boulder), Jake Weltzin (Phenology, National Phenology Network), and Thomas Wilbanks (Energy and Infrastructure; DOE\nOak Ridge National Laboratory). The,Workshops on ecological indicators (supported by EPA), physical climate indicators (supported by NASA), and societal\nindicators (supported by NASA and.NQAA) provided the foundational discussions used to develop the vision of this system." + }, + { + "id": 134267, + "strid": "6bada404-643c-4334-a101-ec371a77e8c0", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 2996.45, + 28.96, + 223.49000000000024, + 229.86999999999998 + ], + "priority": -1, + "parents": [], + "children": [ + 134260, + 134241, + 134233, + 134254, + 134238, + 134230, + 134246, + 134243, + 134248, + 134261, + 134242, + 134229, + 134249, + 134231, + 134247, + 134256, + 134263, + 134264, + 134265, + 134250, + 134262, + 134257, + 134245, + 134259, + 134239, + 134266, + 134240, + 134244, + 134258, + 134232, + 134255 + ], + "area": 86777.192, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 134229, + "strid": "8b256579-d12c-4660-a750-fc2725fd05cd", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 47.99, + 49.317, + 2814.937, + 295.094 + ], + "priority": 1, + "parents": [ + 134267 + ], + "children": [], + "area": 2366.72283, + "iscrowd": 0, + "segmentation": [], + "text": "Collective cortical activity underlying\ndiscrimination of tactile sequences in mice" + }, + { + "id": 134230, + "strid": "b1b52598-4e04-4a96-b27d-ec7331386540", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 52.665, + 376.624, + 2823.456, + 92.43 + ], + "priority": 2, + "parents": [ + 134267 + ], + "children": [], + "area": 19834.90296, + "iscrowd": 0, + "segmentation": [], + "text": "Malamati Bitzidou, Michael R. Bale, Elena Giusto and Miguel Maravall" + }, + { + "id": 134231, + "strid": "51749b1f-9061-4d88-ae60-fd78acb026db", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 69.387, + 685.622, + 322.917, + 50.87699999999995 + ], + "priority": 3, + "parents": [ + 134267 + ], + "children": [ + 134251, + 134252 + ], + "area": 47573.253714, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 134251, + "strid": "78c76488-b09a-4a1c-b564-23e09a7075d5", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 71.674, + 763.121, + 1474.071, + 241.18399999999997 + ], + "priority": 4, + "parents": [ + 134231 + ], + "children": [], + "area": 54695.93455400001, + "iscrowd": 0, + "segmentation": [], + "text": "Making sense of the world around us requires us to process sensory patterns that\nunfold over time. Using hearing, we can accurately recognise speech and melodies.\nUsing touch, mice extract texture and shape by palpating their whiskers over an object.\nIn these patterns, stimulus physical features are concatenated with a particular order\nand timing, and the sequence can only be interpreted by decoding this information." + }, + { + "id": 134252, + "strid": "a52f816e-98a5-4240-befb-ebf43977d0ee", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 69.929, + 1054.888, + 1461.662, + 291.05099999999993 + ], + "priority": 5, + "parents": [ + 134231 + ], + "children": [], + "area": 73767.26295199999, + "iscrowd": 0, + "segmentation": [], + "text": "How neuronal activity in vivo distinguishes between behaviorally relevant sensory\nsequences remains unknown. Which sequence properties are used for\ndiscrimination? Which neural mechanisms and brain regions underpin sequence\nlearning? To explore how sequence discrimination is reflected in neuronal activity, we\ntrained mice in an elementary sequence discrimination task and manipulated and\nrecorded cortical population activity." + }, + { + "id": 134232, + "strid": "a8534237-2a0f-4bda-805b-d44332d618e7", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1660.014, + 513.953, + 249.53099999999995, + 58.98299999999995 + ], + "priority": 6, + "parents": [ + 134267 + ], + "children": [ + 134253 + ], + "area": 853169.1753419999, + "iscrowd": 0, + "segmentation": [], + "text": "Summary" + }, + { + "id": 134253, + "strid": "e07b072f-0977-40cd-85f5-bd9f9e7942ad", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1659.947, + 586.918, + 1556.5090000000002, + 634.862 + ], + "priority": 7, + "parents": [ + 134232 + ], + "children": [], + "area": 974252.773346, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 134246, + "strid": "3357f0e7-d156-409e-a32e-849d5ad42045", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 289.658, + 1468.621, + 1037.3230000000003, + 125.19499999999994 + ], + "priority": 8, + "parents": [ + 134267 + ], + "children": [], + "area": 425397.82161800005, + "iscrowd": 0, + "segmentation": [], + "text": "Whisker-mediated elementary sequence\ndiscrimination" + }, + { + "id": 134259, + "strid": "01ae2df7-521c-42f9-9cb1-360e9e439c83", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 179.422, + 1839.781, + 543.372, + 264.19500000000016 + ], + "priority": 9, + "parents": [ + 134267 + ], + "children": [], + "area": 330097.186582, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 134254, + "strid": "34b80ed3-e09f-4070-abcc-2f5871d855ac", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 764.527, + 1650.986, + 659.615, + 582.9390000000001 + ], + "priority": 10, + "parents": [ + 134267 + ], + "children": [], + "area": 1262223.3736220002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 134244, + "strid": "bfbd4043-9d40-4567-93a8-375487ae7a83", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 116.379, + 2300.874, + 577.694, + 79.63099999999986 + ], + "priority": 11, + "parents": [ + 134267 + ], + "children": [], + "area": 267773.415246, + "iscrowd": 0, + "segmentation": [], + "text": "Example single session: behavioural\nperformance (50 trial moving average)." + }, + { + "id": 134260, + "strid": "3a82eb7d-23d9-4fd0-975b-ef70000b7017", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 104.57, + 2424.862, + 685.501, + 213.0630000000001 + ], + "priority": 12, + "parents": [ + 134267 + ], + "children": [], + "area": 253567.81934, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 134245, + "strid": "4e40dd44-06dd-44ca-92b8-01eeb79a3f52", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 923.228, + 2296.98, + 595.092, + 78.87199999999984 + ], + "priority": 13, + "parents": [ + 134267 + ], + "children": [], + "area": 2120636.25144, + "iscrowd": 0, + "segmentation": [], + "text": "Same session with mouse lick responses\nto GO and NOGO stimuli." + }, + { + "id": 134255, + "strid": "a267a1fe-2c42-4dc8-b8dc-edf18965138a", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 924.614, + 2404.856, + 523.4659999999999, + 489.5300000000002 + ], + "priority": 14, + "parents": [ + 134267 + ], + "children": [], + "area": 2223563.525584, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 134261, + "strid": "0bb0e710-0d5b-48aa-9b57-6e6fccb7a544", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 97.78, + 2920.061, + 742.867, + 810.1929999999998 + ], + "priority": 15, + "parents": [ + 134267 + ], + "children": [], + "area": 285523.56458, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 134243, + "strid": "99602677-041d-4769-94a5-599871c89f81", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 923.962, + 3006.832, + 609.345, + 611.0660000000003 + ], + "priority": 16, + "parents": [ + 134267 + ], + "children": [], + "area": 2778198.508384, + "iscrowd": 0, + "segmentation": [], + "text": "Discriminative lick latencies (times at\nwhich lick rates become different\nbetween GO and NOGO trials) showing\ndifferent strategies across sessions\n\n(n = 121) and mice (n = 30).\n\nSome mice responded on detecting the\nearliest possible GO cue, while others\nwaited. Both strategies could result in\nhigh performance although sessions with\nmore deliberation correlated with higher\nperformance (r = 0.20, p = 0.028,\nPearson; t = 2.41, p = 0.017, mixed-\neffects model with mouse ID as random\nfactor)." + }, + { + "id": 134247, + "strid": "78c5a953-c95d-4877-8e9f-b2857605bc29", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1849.811, + 1314.017, + 1154.566, + 63.40100000000007 + ], + "priority": 17, + "parents": [ + 134267 + ], + "children": [], + "area": 2430683.100787, + "iscrowd": 0, + "segmentation": [], + "text": "Cortical pathway for sequence discrimination" + }, + { + "id": 134249, + "strid": "e649c4b8-c768-4eb5-8708-386c4745353f", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1659.38, + 1419.618, + 1543.817, + 80.606 + ], + "priority": 18, + "parents": [ + 134267 + ], + "children": [], + "area": 2355685.71684, + "iscrowd": 0, + "segmentation": [], + "text": "To track the flow of activity during task performance, we optogenetically inactivated cortical regions in\nVGAT-ChR2 mice on interspersed trials." + }, + { + "id": 134250, + "strid": "f6ba259d-ac58-4c44-a601-4c7d9a10624e", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1785.968, + 1612.25, + 584.383, + 100.88100000000009 + ], + "priority": 19, + "parents": [ + 134267 + ], + "children": [], + "area": 2879426.9080000003, + "iscrowd": 0, + "segmentation": [], + "text": "A Clear-skull cap. B Laser beam profile, TEMOO.\nC Beam spot (scale bar 200 um). FWHM\n364 um. Power at brain surface ~3.5 mW." + }, + { + "id": 134258, + "strid": "f7ade9a6-521e-46ee-a628-1a5fa45626f2", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2404.288, + 1536.623, + 780.0170000000003, + 240.8130000000001 + ], + "priority": 20, + "parents": [ + 134267 + ], + "children": [], + "area": 3694484.239424, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 134256, + "strid": "ca2f453e-2aad-4121-b4b7-6cb143a2ab53", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1661.728, + 1815.048, + 659.5729999999999, + 798.5650000000003 + ], + "priority": 21, + "parents": [ + 134267 + ], + "children": [], + "area": 3016116.082944, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 134248, + "strid": "f2ac26b6-3961-450a-9eb4-09190cdef0d3", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 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"7271fef5-8e59-4509-baaa-7809e2e2673d", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1659.816, + 2794.529, + 1498.802, + 80.7199999999998 + ], + "priority": 24, + "parents": [ + 134267 + ], + "children": [], + "area": 4638403.946664, + "iscrowd": 0, + "segmentation": [], + "text": "These results suggest that the sensory input used for sequence recognition flows through S1bf and S2,\npossibly serially, but that sequence selectivity is learned in higher areas." + }, + { + "id": 134240, + "strid": "af1d8dbf-c3dd-47fa-a232-30f9e03e62d2", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1766.647, + 2960.664, + 1320.583, + 134.38200000000006 + ], + "priority": 25, + "parents": [ + 134267 + ], + "children": [], + "area": 5230448.173608, + "iscrowd": 0, + "segmentation": [], + "text": "Neuronal responses during sequence discrimination\nreflect heterogeneous task variables" + }, + { + "id": 134241, + "strid": "756f4832-d93b-4d72-b352-a0c31786a3ff", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1659.042, + 3120.118, + 1322.9159999999997, + 79.90099999999984 + ], + "priority": 26, + "parents": [ + 134267 + ], + "children": [], + "area": 5176406.806956, + "iscrowd": 0, + "segmentation": [], + "text": "Two-photon imaging revealed heterogeneous neuronal selectivity to variables including\nsensory input, the animal’s decision to lick, and the subsequent action and rewards." + }, + { + "id": 134265, + "strid": "46540b27-ef6d-4f3b-b4fe-16f618147cb6", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2984.318, + 3095.988, + 248.07900000000018, + 199.2750000000001 + ], + "priority": 27, + "parents": [ + 134267 + ], + "children": [], + "area": 9239412.716184, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 134264, + "strid": "3eec7ef8-76c9-4a57-8a50-6dab1b35f524", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1666.818, + 3262.235, + 1501.3300000000002, + 511.78200000000015 + ], + "priority": 28, + "parents": [ + 134267 + ], + "children": [], + "area": 5437552.0182300005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 134262, + "strid": "746a3116-3e4c-4f0c-84bc-864eb1045428", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1716.277, + 3827.126, + 960.1689999999999, + 271.6400000000003 + ], + "priority": 29, + "parents": [ + 134267 + ], + "children": [], + "area": 6568408.329902001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 134238, + "strid": "5237ec67-9c14-419f-ab36-da6cf87d0447", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1728.022, + 4132.165, + 851.444, + 166.82899999999972 + ], + "priority": 30, + "parents": [ + 134267 + ], + "children": [], + "area": 7140472.027629999, + "iscrowd": 0, + "segmentation": [], + "text": "The most frequent neuronal categories in both Sibf and\nPPC respond indiscriminately to sensory stimulation or\npredict decision and/or licking. In contrast, single neurons\ncategorizing trial type are rare." + }, + { + "id": 134263, + "strid": "17dad1f0-6fff-4d37-ba1c-542fb62d326a", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2788.38, + 3862.245, + 409.8649999999998, + 453.6779999999999 + ], + "priority": 31, + "parents": [ + 134267 + ], + "children": [], + "area": 10769406.7131, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 134239, + "strid": "6654643f-7aa4-4fed-85b2-a78b89dc0981", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2632.37, + 4355.895, + 454.192, + 212.03399999999965 + ], + "priority": 32, + "parents": [ + 134267 + ], + "children": [], + "area": 11466327.321150001, + "iscrowd": 0, + "segmentation": [], + "text": "PPC pseudopopulations\ndiscriminate trials similarly to\nS1bf, but their dynamics are\ndelayed relative to the fast\ndecision/licking signals in S1bf." + }, + { + "id": 134233, + "strid": "131bca22-9b53-4ee7-b9d4-3b759ba47379", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 72.04, + 3818.937, + 232.24599999999998, + 48.472999999999956 + ], + "priority": 33, + "parents": [ + 134267 + ], + "children": [ + 134235, + 134236, + 134237, + 134234 + ], + "area": 275116.22148, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 134234, + "strid": "d96c3138-c0b1-4d5d-ba76-cb09baefea6e", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 71.828, + 3888.887, + 1154.064, + 75.7159999999999 + ], + "priority": 34, + "parents": [ + 134233 + ], + "children": [], + "area": 279330.97543600004, + "iscrowd": 0, + "segmentation": [], + "text": "Behaviour and stimulus delivery controlled using Bpod and PulsePal (Sanworks) with\ncustom code (written in Matlab, Mathworks)." + }, + { + "id": 134235, + "strid": "bc516437-2a17-4934-8036-8e3f3527a6af", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 71.829, + 3969.559, + 1190.667, + 154.98999999999978 + ], + "priority": 35, + "parents": [ + 134233 + ], + "children": [], + "area": 285129.45341099997, + "iscrowd": 0, + "segmentation": [], + "text": "Optogenetics: VGAT-ChR2-EYFP mice (Zhao et al, 2011) expressed ChR2 in inhibitory\nneurons. A Cobolt MLD 473 nm laser coupled to a 200 um core optical fibre was focused\nwith a collimator and lens on the cortex through a clear-skull cap (Guo et al, 2014)\n(thanks to M Carandini and C Reddy)." + }, + { + "id": 134236, + "strid": "29b410b1-b51f-42c6-91eb-ec966c8788d6", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 71.712, + 4131.382, + 1203.05, + 273.3239999999996 + ], + "priority": 36, + "parents": [ + 134233 + ], + "children": [], + "area": 296269.66598399996, + "iscrowd": 0, + "segmentation": [], + "text": "Two photon imaging: Thy1-GCaMPé6f mice (Dana et al, 2014). Imaging performed with a\nScientifica microscope (Olympus 20x XLUMPLFLN 1.0NA objective, galvo scanning)\nrunning Scanimage (Vidrio Technologies). Fields of 256x100 were collected at 10.8 Hz. In\ninitial analyses ROIs were traced manually and df/f extracted after neuropil correction. In\nlater analyses a pipeline based on Suite2p was used (Pachitariu et al, 2017). Linear\ndiscriminant classifiers were extracted from pseudopopulations (100 GO trials, 100 NO)\nusing the fitcdiscr command in Matlab." + }, + { + "id": 134237, + "strid": "78d6b888-242f-4b51-9315-0e1635dfe6c6", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1322.713, + 3927.414, + 240.71299999999997, + 268.37099999999964 + ], + "priority": 37, + "parents": [ + 134233 + ], + "children": [], + "area": 5194841.554182, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 134266, + "strid": "48002500-522a-4af3-b86a-17b9860a1bf9", + "image_id": 205708, + "image_name": "15647.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 52.516, + 4463.009, + 1473.252, + 153.17699999999968 + ], + "priority": 38, + "parents": [ + 134267 + ], + "children": [], + "area": 234379.380644, + "iscrowd": 0, + "segmentation": [], + "text": "References: Bale et al (2017) eLife. doi: 10.7554/eLife.27333. Dana et al (2014) PLoS One. doi:\n10.1371/journal.pone.0108697. Guo et al (2014) Neuron. doi: 10.1016/j.neuron.2013.10.020. Pachitariu et al\n(2017) bioRxiv. doi: 10.1101/061507. Zhao et al (2011) Nature Methods. doi: 10.1038/nmeth.1668.\n\nFunding: UK Medical Research Council, grant number MR/P006639/1." + }, + { + "id": 69282, + "strid": "d2cf9eed-3462-430f-bf5b-b3daa076ed38", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 247.53, + 196.24, + 244.49999999999997, + 203.75 + ], + "priority": -1, + "parents": [], + "children": [ + 69242, + 69249, + 69240, + 69243, + 69250, + 69244, + 69247, + 69248, + 69245, + 69246, + 69241 + ], + "area": 48575.2872, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 69240, + "strid": "5a9a48b5-fbab-4e73-bda6-ffdb3d9a2ac6", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 612.504, + 165.319, + 4331.933, + 304.35400000000004 + ], + "priority": 1, + "parents": [ + 69282 + ], + "children": [], + "area": 101258.548776, + "iscrowd": 0, + "segmentation": [], + "text": "Synthetic morphological supermatrices: revealing unknown knowns\nand reducing missing data" + }, + { + "id": 69241, + "strid": "bee2bc93-b7d6-4ea7-b3a0-181ebb9493a4", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 554.262, + 477.225, + 4445.362, + 186.19799999999998 + ], + "priority": 2, + "parents": [ + 69282 + ], + "children": [], + "area": 264507.68295, + "iscrowd": 0, + "segmentation": [], + "text": "James Balhoff':?, Alex Dececchis, Hilmar Lapp’, Paula Mabee?\n‘National Evolutionary Synthesis Center, Durham, NC; 2University of North Carolina, Chapel Hill, NC; University of South Dakota, Vermillion, SD" + }, + { + "id": 69242, + "strid": "4f5bdb81-9a9d-44f2-8ea6-54109789b96b", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 183.634, + 778.554, + 515.742, + 91.52300000000002 + ], + "priority": 3, + "parents": [ + 69282 + ], + "children": [ + 69254 + ], + "area": 142968.98523599998, + "iscrowd": 0, + "segmentation": [], + "text": "Background" + }, + { + "id": 69254, + "strid": "32be78d7-3ab8-4d88-8112-ef86356bf854", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 184.882, + 918.228, + 1201.854, + 1164.6689999999999 + ], + "priority": 4, + "parents": [ + 69242 + ], + "children": [], + "area": 169763.829096, + "iscrowd": 0, + "segmentation": [], + "text": "Phenotypic data describe in detail the structures that\ncontribute to diversity of a specific taxon. But\nintegrating suchdata across broader taxonomic scales\nrequires information that is not directly asserted but\nmay be.embedded. For example, the presence of\ndigits,in-frogs is rarely stated, but the webbing between\nthémr-may be described, and thus the presencesof digits\ncan be inferred.\n\nPresence/absence characters providey;common ground\nto automatically combine data across original studies.\nUsing Web Ontology Language{OWL) reasoning,\ncommunity-developed ontologies, and custom\nsoftware within the Phenoscape Knowledgebase, we\ncan substantially supplément synthetic presence/\nabsence supermatrices»by incorporating inferred states.\n\nAdditionally, taétools make character coverage and\ndata conflictissues explicit, suggesting areas for future\nstudy or improved scoring practices." + }, + { + "id": 69244, + "strid": "d7b1cacb-9261-4244-8e57-0848cd84a327", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 183.111, + 2107.568, + 1078.643, + 94.30299999999988 + ], + "priority": 5, + "parents": [ + 69282 + ], + "children": [ + 69268, + 69277, + 69255, + 69256 + ], + "area": 385918.88404800004, + "iscrowd": 0, + "segmentation": [], + "text": "Entity—Quality annotation" + }, + { + "id": 69255, + "strid": "d5a1be27-9867-459e-a774-a6d3521ae8bb", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 207.659, + 2233.201, + 1107.257, + 403.76900000000023 + ], + "priority": 6, + "parents": [ + 69244 + ], + "children": [], + "area": 463744.28645899997, + "iscrowd": 0, + "segmentation": [], + "text": "Rhenoscape curators annotate free-textphenotypic\ncharacter state descriptions from morphological\nphylogenetic matrices, using the Entity—Quality\nsemantic model. EQ associates an entity term\ndrawn from an anatomical ontology, such as\nUBERON, with a quality term from the generic\nPhenotype and Trait Ontology (PATO)." + }, + { + "id": 69268, + "strid": "80defcc6-522c-40b6-9f0d-8432604ecfa2", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 186.033, + 2663.825, + 1194.998, + 656.0460000000003 + ], + "priority": 7, + "parents": [ + 69244 + ], + "children": [], + "area": 495559.35622499994, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 69277, + "strid": "43679c26-9cfd-441e-9ddf-04883caf7d21", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 200.524, + 3335.205, + 1084.694, + 112.73500000000013 + ], + "priority": 8, + "parents": [ + 69244 + ], + "children": [], + "area": 668788.6474199999, + "iscrowd": 0, + "segmentation": [], + "text": "Using standard terms from community ontologies\nlinks this description into a websofdomain axioms:" + }, + { + "id": 69256, + "strid": "665e5773-2b5d-4b20-b205-0791fa8a53d9", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 218.619, + 3453.599, + 1098.806, + 463.71000000000004 + ], + "priority": 9, + "parents": [ + 69244 + ], + "children": [], + "area": 755022.3597810001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 69243, + "strid": "4013ada6-6615-4273-9c21-75ae97717fc1", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1513.891, + 778.082, + 1063.4680000000003, + 90.17499999999995 + ], + "priority": 10, + "parents": [ + 69282 + ], + "children": [ + 69258, + 69280, + 69269, + 69257 + ], + "area": 1177931.337062, + "iscrowd": 0, + "segmentation": [], + "text": "Combining asserted data" + }, + { + "id": 69257, + "strid": "5f2cb35b-2c3f-457d-90bc-dffc1b8206d2", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1526.453, + 948.137, + 1198.5260000000003, + 400.404 + ], + "priority": 11, + "parents": [ + 69243 + ], + "children": [], + "area": 1447286.568061, + "iscrowd": 0, + "segmentation": [], + "text": "The Phenoscape Knowledgebase contains ontology-\nannotated phenotypic data from 139.comparative\nstudies.\n\nIt is thus straightforward to export a presence/absence\ndataset for any list of anatomical terms, combining\nasserted presence/absence data across input matrices." + }, + { + "id": 69280, + "strid": "2a78edec-643f-472b-a94e-693ec9f90fd9", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1526.684, + 1417.42, + 1151.023, + 55.440000000000055 + ], + "priority": 12, + "parents": [ + 69243 + ], + "children": [], + "area": 2163952.43528, + "iscrowd": 0, + "segmentation": [], + "text": "Example query: limb-structures in Sarcopterygii" + }, + { + "id": 69258, + "strid": 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69282 + ], + "children": [ + 69281, + 69271, + 69270, + 69264, + 69265, + 69278, + 69262, + 69263 + ], + "area": 2620153.8648380004, + "iscrowd": 0, + "segmentation": [], + "text": "Inferring data using ontologies" + }, + { + "id": 69264, + "strid": "d7eddd72-b329-4081-9552-7d08b0a6b90c", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1516.587, + 1819.698, + 2292.075, + 110.83200000000011 + ], + "priority": 16, + "parents": [ + 69245 + ], + "children": [], + "area": 2759730.330726, + "iscrowd": 0, + "segmentation": [], + "text": "Inferred presence/absence is readily computed using OWL reasoning via the ELK reasoner and the\nPhenoscape Knowledgebase" + }, + { + "id": 69278, + "strid": "1c56634a-671c-435e-8908-736a40803459", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1534.996, + 1971.789, + 1030.257, + 159.7900000000002 + ], + "priority": 17, + "parents": [ + 69245 + ], + "children": [], + "area": 3026688.2278440003, + "iscrowd": 0, + "segmentation": [], + "text": "Presence propagation—“up the chain”\nPresence of a structure can be logieally inferred\nfrom:" + }, + { + "id": 69262, + "strid": "0a1871b6-8f10-400b-935d-ce89f0b8d5ff", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1535.622, + 2143.361, + 1079.3509999999999, + 229.41699999999992 + ], + "priority": 18, + "parents": [ + 69245 + ], + "children": [], + "area": 3291392.305542, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 69271, + "strid": "d2fcf51f-e81f-4a8a-96e0-37c3447fcade", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1547.114, + 2442.625, + 1105.9990000000003, + 430.7359999999999 + ], + "priority": 19, + "parents": [ + 69245 + ], + "children": [], + "area": 3779019.3342500003, + "iscrowd": 0, + "segmentation": [] + }, + 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"category_id": 2, + "category_name": "Figure", + "bbox": [ + 2784.353, + 2426.67, + 1131.967, + 352.7289999999998 + ], + "priority": 22, + "parents": [ + 69245 + ], + "children": [], + "area": 6756705.89451, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 69265, + "strid": "925c29dd-5f79-43de-a368-faf5bb23bebb", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1887.358, + 2804.662, + 2153.656, + 61.09700000000021 + ], + "priority": 23, + "parents": [ + 69245 + ], + "children": [], + "area": 5293401.262995999, + "iscrowd": 0, + "segmentation": [], + "text": "The complete reasoningyprocess is described online in our paper-for the ISMB 2014 Phenotype Day." + }, + { + "id": 69246, + "strid": "6e3d7cd2-143c-41ae-9460-1723a1ab9b47", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1522.15, + 2921.7, + 1451.7710000000002, + 95.32400000000007 + ], + "priority": 24, + "parents": [ + 69282 + ], + "children": [ + 69272, + 69261, + 69279, + 69267 + ], + "area": 4447265.655, + "iscrowd": 0, + "segmentation": [], + "text": "Missing data significantly reduced" + }, + { + "id": 69279, + "strid": "e65009a1-3f07-4a7e-8170-473a9be70ada", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1526.885, + 3063.796, + 899.1189999999999, + 53.75500000000011 + ], + "priority": 25, + "parents": [ + 69246 + ], + "children": [], + "area": 4678064.15546, + "iscrowd": 0, + "segmentation": [], + "text": "After incorporating ontologicalinferences:" + }, + { + "id": 69261, + "strid": "b7675a2d-63b8-400e-895f-6a76206b7390", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1527.755, + 3119.905, + 1209.534, + 289.7339999999999 + ], + "priority": 26, + "parents": [ + 69246 + ], + "children": [], + "area": 4766450.463275, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 69267, + "strid": "31e0601e-3da6-4464-85da-a4898ecfb7e6", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1573.279, + 3555.408, + 972.73, + 292.5529999999999 + ], + "priority": 27, + "parents": [ + 69246 + ], + "children": [], + "area": 5593648.742831999, + "iscrowd": 0, + "segmentation": [], + "text": "Thegenerated matrix is output in the NeXMk\ndata format, and includes embedded\nannotations linking inferred\n\ndata back to supporting [NexXML]\npublished character states, Wr enfonijermatic data" + }, + { + "id": 69272, + "strid": "62014937-26b8-42d5-acf6-3fcb363e6079", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2831.228, + 3045.806, + 1215.502, + 818.1610000000001 + ], + "priority": 28, + "parents": [ + 69246 + ], + "children": [], + "area": 8623371.229768, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 69247, + "strid": "3b19cf15-0865-4278-b6bf-e44c669b75ee", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4191.941, + 777.836, + 606.9949999999999, + 92.29600000000005 + ], + "priority": 29, + "parents": [ + 69282 + ], + "children": [ + 69252, + 69274, + 69273 + ], + "area": 3260642.619676, + "iscrowd": 0, + "segmentation": [], + "text": "Dataxcoverage" + }, + { + "id": 69252, + "strid": "6ef49e99-5f0f-439f-92f2-7406ad9f494a", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4182.091, + 955.808, + 532.3060000000005, + 219.54600000000005 + ], + "priority": 30, + "parents": [ + 69247 + ], + "children": [], + "area": 3997276.0345280003, + "iscrowd": 0, + "segmentation": [], + "text": "The_distribution of data\ncan be examined across\nanatomy, and across the\ntree of life." + }, + { + "id": 69274, + "strid": "95a989a0-0ff1-47e0-8c9a-e2d338d88057", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 4313.775, + 1235.34, + 281.6700000000001, + 220.15599999999995 + ], + "priority": 31, + "parents": [ + 69247 + ], + "children": [], + "area": 5328978.808499999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 69273, + "strid": "129a70b7-6c41-4638-bbf6-c74c0841d0f6", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 4739.941, + 895.621, + 640.0910000000003, + 553.12 + ], + "priority": 32, + "parents": [ + 69247 + ], + "children": [], + "area": 4245190.698361, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 69248, + "strid": "f6fa5b24-8160-4a8f-903e-7fa2c78f2787", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4183.5, + 1494.016, + 578.3220000000001, + 75.01800000000003 + ], + "priority": 33, + "parents": [ + 69282 + ], + "children": [ + 69276, + 69259, + 69266, + 69253, + 69275 + ], + "area": 6250215.936000001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 69253, + "strid": "0c0cb74e-c86f-468b-9067-1a3c1b844ed5", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4205.232, + 1600.83, + 1092.156, + 159.73700000000008 + ], + "priority": 34, + "parents": [ + 69248 + ], + "children": [], + "area": 6731861.54256, + "iscrowd": 0, + "segmentation": [], + "text": "816 cells (outof 142,393 populated) assign both\npresence‘and absence of a structure to the same\ntaxon. Reasons include:" + }, + { + "id": 69259, + "strid": "faef723d-387a-4268-98a4-c1fefd19e459", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 4207.87, + 1790.364, + 615.5, + 628.1190000000001 + ], + "priority": 35, + "parents": [ + 69248 + ], + "children": [], + "area": 7533618.96468, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 69275, + "strid": "96826428-b70d-473d-8bd2-b4dfe40aa814", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 4856.248, + 1761.467, + 534.4949999999999, + 394.86299999999983 + ], + "priority": 36, + "parents": [ + 69248 + ], + "children": [], + "area": 8554120.595816, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 69276, + "strid": "35045867-190e-4ac7-a448-b4ab36507bfa", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4866.202, + 2184.199, + 535.4899999999998, + 228.92700000000013 + ], + "priority": 37, + "parents": [ + 69248 + ], + "children": [], + "area": 10628753.542198, + "iscrowd": 0, + "segmentation": [], + "text": "Opposing concepts\n\n“radials: jointed”: some authors\ndistinguish radials from digits,\nwhile others lump together via\nhomology" + }, + { + "id": 69266, + "strid": "62cde382-8740-4db7-9277-b4b15e8fd7eb", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4222.743, + 2492.728, + 1058.4229999999998, + 112.28499999999985 + ], + "priority": 38, + "parents": [ + 69248 + ], + "children": [], + "area": 10526149.712904, + "iscrowd": 0, + "segmentation": [], + "text": "Logical inconsistency across matrix characters is\nreadily revealed by this system." + }, + { + "id": 69249, + "strid": "5981a873-a744-407e-bef6-7a9f365cd883", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4191.045, + 2700.701, + 726.1329999999998, + 72.68299999999999 + ], + "priority": 39, + "parents": [ + 69282 + ], + "children": [ + 69260 + ], + "area": 11318759.422545, + "iscrowd": 0, + "segmentation": [], + "text": "e information" + }, + { + "id": 69260, + "strid": "e8c31eea-0581-445f-811b-d0d878d1c92a", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 4193.404, + 2826.651, + 1091.0329999999994, + 458.6199999999999 + ], + "priority": 40, + "parents": [ + 69249 + ], + "children": [], + "area": 11853289.610004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 69250, + "strid": "1523de5e-fd9f-4b2c-87f4-5c42fef58695", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4185.277, + 3322.607, + 786.0100000000002, + 91.97200000000021 + ], + "priority": 41, + "parents": [ + 69282 + ], + "children": [ + 69251 + ], + "area": 13906030.657139, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgments" + }, + { + "id": 69251, + "strid": "f7e5e568-56af-4c6d-8b70-d7f92d30ae6e", + "image_id": 203207, + "image_name": "119861.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4209.797, + 3476.483, + 1122.8810000000003, + 229.3510000000001 + ], + "priority": 42, + "parents": [ + 69250 + ], + "children": [], + "area": 14635287.703951, + "iscrowd": 0, + "segmentation": [], + "text": "The Phenoscape project is funded by NSF\n(DBI-1062404 and DBI-1062542), and supported by\nthe National Evolutionary Synthesis Center\n(NESCent), NSF EF-0423641." + }, + { + "id": 77781, + "strid": "cad253ce-669c-4627-a7df-91f68aa0c3ea", + "image_id": 203532, + "image_name": "120421.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 2826.67, + 538.55, + 303.0699999999997, + 221.7700000000001 + ], + "priority": -1, + "parents": [], + "children": [ + 77777, + 77764, + 77774, + 77763, + 77761, + 77768, + 77778, + 77776, + 77765, + 77762 + ], + "area": 1522303.1284999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 77761, + "strid": "63ace4c1-2441-4fe0-8e5b-b06bd8169d67", + "image_id": 203532, + "image_name": "120421.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 775.164, + 101.38, + 1759.148, + 338.307 + ], + "priority": 1, + "parents": [ + 77781 + ], + "children": [], + "area": 78586.12632, + "iscrowd": 0, + "segmentation": [], + "text": "Computational prediction of protein\ninteraction motifs from integrated protein\nsequence, structure and interaction data" + }, + { + "id": 77762, + "strid": "aae7100b-dacc-4a87-96a0-86778e1d9e0a", + "image_id": 203532, + "image_name": "120421.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1035.206, + 496.645, + 1243.57, + 84.94600000000003 + ], + "priority": 2, + "parents": [ + 77781 + ], + "children": [], + "area": 514129.88386999996, + "iscrowd": 0, + "segmentation": [], + "text": "Nicolas Palopoli & Richard J Edwards" + }, + { + "id": 77763, + "strid": "68fe301b-1e25-4c7e-834a-d5085a9f34c8", + "image_id": 203532, + "image_name": "120421.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 78.668, + 732.754, + 608.386, + 108.28899999999999 + ], + "priority": 3, + "parents": [ + 77781 + ], + "children": [ + 77771, + 77772, + 77766, + 77770, + 77773 + ], + "area": 57644.29167200001, + "iscrowd": 0, + "segmentation": [], + "text": "Background" + }, + { + "id": 77766, + "strid": "a636fef6-7056-4f6f-881f-11d2f7431adc", + "image_id": 203532, + "image_name": "120421.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 41.873, + 866.775, + 1468.559, + 657.6340000000001 + ], + "priority": 4, + "parents": [ + 77763 + ], + "children": [], + "area": 36294.469574999996, + "iscrowd": 0, + "segmentation": [], + "text": "Protein-protein interactions (PPI) between globular domains and\nShort Linear Motifs (SLiMs) play a crucial part in many biological\nprocesses. SLiMs are short stretches of 5 to 15 amino acids with\nhigh evolutionary plasticity that are usually found in disordered\nregions of proteins. Their role as ligands for molecular signalling,\npost-translational modifications and subcellular targeting has\nbeen increasingly studied over recent years, but experimental\ndiscovery of SLiIMs remains a challenging task due to their small\nsize and high degeneracy. As a consequence, computational tool:\nfor prediction and analysis of SLiMs are a valuable resource." + }, + { + "id": 77770, + "strid": "25052216-b589-4cd1-8a93-b60411c1f614", + "image_id": 203532, + "image_name": "120421.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 73.279, + 1653.828, + 789.226, + 282.1859999999999 + ], + "priority": 5, + "parents": [ + 77763 + ], + "children": [], + "area": 121190.862012, + "iscrowd": 0, + "segmentation": [], + "text": "What is a Short Linear Motif?\n\nShort Linear Motifs (SLiMs) are protein interaction motifs\nwith certain defining characteristics:\n\nShort: generally <10aa long with <6 defined residues\nLinear: involving residues adjacent in sequence\nMotifs: a recurring sequence pattern required for function" + }, + { + "id": 77773, + "strid": "3a596327-529b-476f-9ef9-82cfd6083872", + "image_id": 203532, + "image_name": "120421.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 895.807, + 1651.539, + 576.8010000000002, + 277.462 + ], + "priority": 6, + "parents": [ + 77763 + ], + "children": [], + "area": 1479460.196973, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 77771, + "strid": "8279162a-b9c2-47cb-8bc6-528758d7bfb7", + "image_id": 203532, + "image_name": "120421.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1949.653, + 919.298, + 1241.858, + 265.23800000000006 + ], + "priority": 7, + "parents": [ + 77763 + ], + "children": [], + "area": 1792312.103594, + "iscrowd": 0, + "segmentation": [], + "text": "QSLiMFinder: the algorithm\n\nQSLiMFinder is a variant of the SLiMFinder algorithm. SLiMFinder uses search parameters\nto construct the motif space and then searches the whole dataset for over-representation.\nQSLiMFinder takes one protein/region from the dataset as the “query”, constructs the\n(reduced) motif space from it and searches the remaining unrelated proteins." + }, + { + "id": 77772, + "strid": "50f2ada7-a182-4b1b-ad56-a5b7f2aea4cc", + "image_id": 203532, + "image_name": "120421.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1703.103, + 1220.58, + 1496.902, + 705.9360000000001 + ], + "priority": 8, + "parents": [ + 77763 + ], + "children": [], + "area": 2078773.4597399998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 77764, + "strid": "150a9184-6f17-40dd-a153-3c6cac1bcfa3", + "image_id": 203532, + "image_name": "120421.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 70.439, + 2072.962, + 210.12999999999997, + 85.21199999999999 + ], + "priority": 9, + "parents": [ + 77781 + ], + "children": [ + 77767 + ], + "area": 146017.37031799997, + "iscrowd": 0, + "segmentation": [], + "text": "Aim" + }, + { + "id": 77767, + "strid": "44f0157c-98d6-4f38-89bb-bf1d30cf2e5f", + "image_id": 203532, + "image_name": "120421.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 53.976, + 2230.315, + 1846.4, + 324.07299999999987 + ], + "priority": 10, + "parents": [ + 77764 + ], + "children": [], + "area": 120383.48244, + "iscrowd": 0, + "segmentation": [], + "text": "We have previously developed SLiMFinder, a motif discovery tool that applies a\nmodel of convergent evolution to estimate the statistical significance of over-\nrepresented motifs with high specificity. Here, we aim to improve motif discovery\nby integrating SLiMFinder with methods that predict new domain-motif\ninteractions directly from structural features in high-resolution 3D data." + }, + { + "id": 77765, + "strid": "1c4b26f2-0fb0-414f-b208-b95e78b4b7d0", + "image_id": 203532, + "image_name": "120421.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 73.548, + 2661.687, + 494.999, + 105.49800000000005 + ], + "priority": 11, + "parents": [ + 77781 + ], + "children": [ + 77775, + 77769, + 77779 + ], + "area": 195761.755476, + "iscrowd": 0, + "segmentation": [], + "text": "Approach" + }, + { + "id": 77769, + "strid": "d3b35cf1-a836-4389-b4b8-d49c61c73524", + "image_id": 203532, + "image_name": "120421.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 48.566, + 2829.684, + 1878.113, + 56.653999999999996 + ], + "priority": 12, + "parents": [ + 77765 + ], + "children": [], + "area": 137426.433144, + "iscrowd": 0, + "segmentation": [], + "text": "We are now applying QSLiIMFinder to large-scale analysis of public PPI and 3D data." + }, + { + "id": 77775, + "strid": "eb6478e3-373d-4de1-90a3-60e9da72ccf1", + "image_id": 203532, + "image_name": "120421.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 86.219, + 2934.802, + 1870.442, + 584.502 + ], + "priority": 13, + "parents": [ + 77765 + ], + "children": [], + "area": 253035.693638, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 77779, + "strid": "9713956c-6300-4b29-a302-150b63bc4c50", + "image_id": 203532, + "image_name": "120421.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 47.614, + 3583.047, + 1844.519, + 255.1010000000001 + ], + "priority": 14, + "parents": [ + 77765 + ], + "children": [], + "area": 170603.19985799998, + "iscrowd": 0, + "segmentation": [], + "text": "Domain-motif interactions are predicted from structures in the Protein Data Bank\n(PDB). QSLiMFinder then identifies patterns within the putative motif region that\nare over-represented in the other known PPI partners of the domain-containing\n\nprotein." + }, + { + "id": 77777, + "strid": "42c92c34-5248-442c-9bb3-76d76a1b5e62", + "image_id": 203532, + "image_name": "120421.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 76.609, + 3920.972, + 801.344, + 106.56100000000015 + ], + "priority": 15, + "parents": [ + 77781 + ], + "children": [ + 77780 + ], + "area": 300381.743948, + "iscrowd": 0, + "segmentation": [], + "text": "Further reading" + }, + { + "id": 77780, + "strid": "21d90427-a827-4d8c-b20f-93a054889e71", + "image_id": 203532, + "image_name": "120421.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 44.396, + 4071.089, + 1889.983, + 313.83799999999974 + ], + "priority": 16, + "parents": [ + 77777 + ], + "children": [], + "area": 180740.067244, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 77774, + "strid": "a3e9e0ba-b2a0-423f-a4e3-03eb9051f7dd", + "image_id": 203532, + "image_name": "120421.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2087.651, + 2184.526, + 1083.9809999999998, + 582.8989999999999 + ], + "priority": 17, + "parents": [ + 77781 + ], + "children": [], + "area": 4560527.888425999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 77768, + "strid": "a12bafb8-8a98-47ad-808e-5cf2e8beae67", + "image_id": 203532, + "image_name": "120421.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2041.763, + 2806.743, + 1160.9629999999997, + 259.5430000000001 + ], + "priority": 18, + "parents": [ + 77781 + ], + "children": [], + "area": 5730704.007909, + "iscrowd": 0, + "segmentation": [], + "text": "We have benchmarked QSLiMFinder using the Eukaryotic Linear\nMotif (ELM) database and simulated data. As expected, using\nspecific interaction data (here used to 'zoom-in' in the region\ncarrying the motif) can increase the power of de novo SLiM\nprediction from a set of proteins with a common PPI partner." + }, + { + "id": 77778, + "strid": "7e014c9f-b329-4601-b5a3-b70a23abb9bd", + "image_id": 203532, + "image_name": "120421.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2057.521, + 3247.376, + 1129.127, + 218.8499999999999 + ], + "priority": 19, + "parents": [ + 77781 + ], + "children": [], + "area": 6681544.3148960015, + "iscrowd": 0, + "segmentation": [], + "text": "Relative Conservation Masking\n\nIn addition to masking out globular “ordered” regions (as predicted\nby IUPred), selectively retaining residues with higher conservation\nthan their local context significantly improves results." + }, + { + "id": 77776, + "strid": "c61e406d-08c8-4163-ac82-9f096f8350ee", + "image_id": 203532, + "image_name": "120421.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2050.741, + 3507.007, + 1143.659, + 816.6479999999997 + ], + "priority": 20, + "parents": [ + 77781 + ], + "children": [], + "area": 7191963.042187, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 111922, + "strid": "8bf5fb04-6b79-480a-81c5-a3d72934cbfb", + "image_id": 204844, + "image_name": "13265.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 62.24, + 148.78, + 325.99, + 217.32000000000002 + ], + "priority": -1, + "parents": [], + "children": [ + 111913, + 111909, + 111907, + 111921, + 111912, + 111910, + 111908, + 111919, + 111911 + ], + "area": 9260.0672, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 111907, + "strid": "0344ade2-b5c6-49ee-a094-635ccea40adb", + "image_id": 204844, + "image_name": "13265.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 84.3, + 39.292, + 3338.039, + 251.564 + ], + "priority": 1, + "parents": [ + 111922 + ], + "children": [], + "area": 3312.3156, + "iscrowd": 0, + "segmentation": [], + "text": "Farming with nature: using precision agriculture to rescue arthropod\npopulations and provide ecosystem services ; @ &" + }, + { + "id": 111908, + "strid": "0d0eb735-9103-4aa9-9a64-d6d43e7b45a2", + "image_id": 204844, + "image_name": "13265.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 83.683, + 294.907, + 1086.514, + 105.19099999999997 + ], + "priority": 2, + "parents": [ + 111922 + ], + "children": [], + "area": 24678.702481, + "iscrowd": 0, + "segmentation": [], + "text": "Aleksandra Dolezal, Ellen Esch, Andrew MacDougall\nDepartment of Integrative Biology, University of Guelph" + }, + { + "id": 111909, + "strid": "90318b08-7617-4cd4-8be7-b5c912d77252", + "image_id": 204844, + "image_name": "13265.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 112.495, + 437.61, + 483.727, + 81.91600000000005 + ], + "priority": 3, + "parents": [ + 111922 + ], + "children": [ + 111916 + ], + "area": 49228.93695, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 111916, + "strid": "4d2562aa-0ec3-422e-9dae-41aa2edac016", + "image_id": 204844, + "image_name": "13265.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 82.945, + 540.392, + 1474.891, + 933.433 + ], + "priority": 4, + "parents": [ + 111909 + ], + "children": [], + "area": 44822.81444, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 111919, + "strid": "685c7dfc-e94f-4539-82b9-cc0725e7150f", + "image_id": 204844, + "image_name": "13265.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1645.499, + 364.235, + 2079.483, + 1080.1769999999997 + ], + "priority": 5, + "parents": [ + 111922 + ], + "children": [], + "area": 599348.328265, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 111921, + "strid": "6bc5f581-d46f-4952-9022-40262e59661c", + "image_id": 204844, + "image_name": "13265.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 93.461, + 1562.102, + 3624.456, + 2230.755 + ], + "priority": 6, + "parents": [ + 111922 + ], + "children": [], + "area": 145995.615022, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 111910, + "strid": "c298139a-19d5-46d7-bfdb-9efc5a0ee49e", + "image_id": 204844, + "image_name": "13265.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 92.208, + 4058.173, + 454.572, + 78.6880000000001 + ], + "priority": 7, + "parents": [ + 111922 + ], + "children": [ + 111917 + ], + "area": 374196.015984, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion" + }, + { + "id": 111917, + "strid": "a4fcf71f-e668-4f7d-b98a-e1c73394897d", + "image_id": 204844, + "image_name": "13265.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 86.312, + 4159.895, + 1811.464, + 358.28899999999976 + ], + "priority": 8, + "parents": [ + 111910 + ], + "children": [], + "area": 359048.85724000004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 111913, + "strid": "61396455-064c-424d-b975-c29aacb8024f", + "image_id": 204844, + "image_name": "13265.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1945.875, + 4497.65, + 418.9000000000001, + 51.34900000000016 + ], + "priority": 9, + "parents": [ + 111922 + ], + "children": [ + 111914, + 111920 + ], + "area": 8751864.69375, + "iscrowd": 0, + "segmentation": [], + "text": "About the author" + }, + { + "id": 111914, + "strid": "3fd9c1c2-66df-4fad-97f6-f3d048b6ea92", + "image_id": 204844, + "image_name": "13265.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1948.788, + 4560.958, + 998.027, + 168.27700000000004 + ], + "priority": 10, + "parents": [ + 111913 + ], + "children": [], + "area": 8888340.218904, + "iscrowd": 0, + "segmentation": [], + "text": "My curiosity about plant and animal interactions, as well as my\nnatural scientific curiosity, is what led me to pursue research in\necology. My research interests are focused on conservation\nefforts, environmental assessment, and all things insect related." + }, + { + "id": 111920, + "strid": "51fd4790-94ea-41bb-8c51-7a492f0747d5", + "image_id": 204844, + "image_name": "13265.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2974.269, + 4478.157, + 287.98799999999983, + 273.95799999999963 + ], + "priority": 11, + "parents": [ + 111913 + ], + "children": [], + "area": 13319243.542233, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 111912, + "strid": "fdff7979-46aa-4f55-b775-7e50bae23733", + "image_id": 204844, + "image_name": "13265.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1963.349, + 4311.828, + 485.3549999999998, + 58.19999999999982 + ], + "priority": 12, + "parents": [ + 111922 + ], + "children": [ + 111915 + ], + "area": 8465623.191972, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements" + }, + { + "id": 111915, + "strid": "9f700261-dc5f-4b60-b062-ab0053752adf", + "image_id": 204844, + "image_name": "13265.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1950.174, + 4372.921, + 1729.647, + 79.8100000000004 + ], + "priority": 13, + "parents": [ + 111912 + ], + "children": [], + "area": 8527956.838254001, + "iscrowd": 0, + "segmentation": [], + "text": "| want to thank the MacDougall lab for providing support and ongoing dedication to this project; all the field techs who\nhelped with insect surveys and identification; OMAFRA HQP for funding and ALUS Canada for providing study sites" + }, + { + "id": 111911, + "strid": "67a0a587-ff5f-41c7-ba8a-155a216a1c48", + "image_id": 204844, + "image_name": "13265.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1959.088, + 4058.074, + 284.29600000000005, + 48.526000000000295 + ], + "priority": 14, + "parents": [ + 111922 + ], + "children": [ + 111918 + ], + "area": 7950124.076512, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 111918, + "strid": "099d8cbd-c86e-4b8e-bb18-654edb3912ae", + "image_id": 204844, + "image_name": "13265.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1954.8, + 4118.228, + 1768.894, + 158.10999999999967 + ], + "priority": 15, + "parents": [ + 111911 + ], + "children": [], + "area": 8050312.0944, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 151053, + "strid": "02946ea7-bcea-4f3e-924d-6fdaebb0ef5e", + "image_id": 206373, + "image_name": "21148.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 129.45, + 5039.35, + 389.90000000000003, + 252.27999999999975 + ], + "priority": -1, + "parents": [], + "children": [ + 151048, + 151051, + 151049, + 151052, + 151044, + 151050 + ], + "area": 652343.8575, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 151044, + "strid": "6b44cca9-8e6c-4ea1-b8fe-d479c2bd56db", + "image_id": 206373, + "image_name": "21148.png", + "category_id": 1, + "category_name": "Title", + "bbox": 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"category_id": 1, + "category_name": "Title", + "bbox": [ + 454.575, + 157.382, + 2570.784, + 57.91 + ], + "priority": 1, + "parents": [ + 56756 + ], + "children": [], + "area": 71541.92265000001, + "iscrowd": 0, + "segmentation": [], + "text": "TYPING OF STREPTOCOCCUS MILLERI GROUP BY MOLECULAR AND BIOCHEMICAL METHODS" + }, + { + "id": 56734, + "strid": "b67590df-692c-419a-ba76-bfe79ac92c29", + "image_id": 202737, + "image_name": "119166.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 456.644, + 221.497, + 2364.8679999999995, + 142.70599999999996 + ], + "priority": 2, + "parents": [ + 56756 + ], + "children": [], + "area": 101145.276068, + "iscrowd": 0, + "segmentation": [], + "text": "Gunel G, Gurler B\nIstanbul University, Istanbul Medical Faculty, Microbiology and Clinical Microbiology Department, Istanbul, Turkey" + }, + { + "id": 56735, + "strid": "4e308b92-cff8-4abd-918d-9782e27db151", + "image_id": 202737, + "image_name": "119166.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 146.412, + 511.046, + 461.211, + 57.910000000000025 + ], + "priority": 3, + "parents": [ + 56756 + ], + "children": [ + 56736 + ], + "area": 74823.266952, + "iscrowd": 0, + "segmentation": [], + "text": "INTRODUCTION" + }, + { + "id": 56736, + "strid": "a4ee49ab-9877-47ad-83b6-c3e50d24f8b1", + "image_id": 202737, + "image_name": "119166.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 84.366, + 591.706, + 1778.66, + 953.4440000000001 + ], + "priority": 4, + "parents": [ + 56735 + ], + "children": [], + "area": 49919.868396, + "iscrowd": 0, + "segmentation": [], + "text": "Streptococci detected in various regions of the body as normal flora are Gram\npositive diplococci, non-spore forming and non-motile bacteria. Streptococci can be\nclassified according to biochemical and antigenic properties and the ability to produce\nhemolysis on blood agar. The diameter of beta hemolitic streptococci colonies are\ngenerally greater than 0.5 mm and these are called pyogen; on the other hand bacteria\nwhose colonies are smaller than 0.5 mm (pin-point) are called Streptococcus milleri\ngroup in Europe and Streptococcus anginosus group in America. Streptococcus\nmilleri group are classified into three species; Streptococcus anginosus, Streptococcus\nintermedius, Streptococcus constellatus. S. milleri group bacteria are genetically related\nto non-hemolitic streptococci. S. milleri group bacteria’s DNA structure reminds non-\nhemolitic streptococci. They are found as commensal in oropharyngeal, urogenital,\ngastrointestinal tract. They are Voges-Proskauer (VP) positive, esculin hydrolisis\npositive, pyrrolidonyl arylamidase (PYR) negative, urease negative, hippurat hydrolisis\nnegative; these biochemical reactions distinguish them from other Streptococci. VP\ntest’s differantation is the most important feature; it is positive in S.milleri group, where\nas it is negative in other beta-hemoliytic streptococci." + }, + { + "id": 56737, + "strid": "be391d24-b80a-4155-9fe4-e030f839882f", + "image_id": 202737, + "image_name": "119166.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 143.204, + 1655.479, + 791.4070000000002, + 54.519000000000005 + ], + "priority": 5, + "parents": [ + 56756 + ], + "children": [ + 56738 + ], + "area": 237071.21471600002, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 56738, + "strid": "713f6ce7-a69e-4358-bd86-cec66f24d320", + "image_id": 202737, + "image_name": "119166.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 78.512, + 1724.694, + 1744.834, + 1019.4740000000002 + ], + "priority": 6, + "parents": [ + 56737 + ], + "children": [], + "area": 135409.175328, + "iscrowd": 0, + "segmentation": [], + "text": "100 streptococci strains were isolated from throat samples and also from other\nbody sites such as abcess, blood and pustules. VP, CAMP tests, esculin and urease\nhydrolisis, sugar fermatation tests and Niven’s arginin hydrolysis test (1) were carried\nout for pin-point colonies and species identification was carried by API 20 Strep kit\nand by PCR. Antibiotic susceptibility testing was carried out according to Clinical\nand Laboratory Standards Institute (CLSI criteria (2). For the Niven’s arginin\nhydrolise test At the end of incubation, | drop arginine Nessler reagent was added into\nthe tubes. Bright yellow color indicative of the ammonia being produced by the\nbacteria means positive. In hippurate hydrolysis experiments, 2 McFarland. colony\nsuspension were prepared, and the suspension was incubated for 2 hours at 37°C.\nAfter incubation 0.4 ml ninhydrin reagent was added on. After 15 minutes, the lack of\ncolor change or the presence of light purple indicates negativity where as dark purple-\nblue color formation shows the positivity. Genus and species level idenmtification\nwas also carried out by API 20 Strep. In our study primarily S.milleri to group\npreviously been used and the specific gene region, almost all the types of genes that\nencode region-specific HYL-MIX-U, HLY-INT-D, HLY-CC-D, 16S-ANG, the 16S -\nANG-D ily-4dfw ily-wholec Bw primers were used (3)." + }, + { + "id": 56740, + "strid": "26cc2f94-cdb1-47a9-beac-217da7805745", + "image_id": 202737, + "image_name": "119166.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 128.894, + 2820.401, + 256.469, + 51.5329999999999 + ], + "priority": 7, + "parents": [ + 56756 + ], + "children": [ + 56745, + 56747, + 56741, + 56739, + 56748, + 56744, + 56746, + 56743 + ], + "area": 363532.766494, + "iscrowd": 0, + "segmentation": [], + "text": "RESULTS" + }, + { + "id": 56739, + "strid": "7e213eb7-25b0-4f06-bbea-5c0ff195b336", + "image_id": 202737, + "image_name": "119166.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 80.861, + 2886.412, + 1742.935, + 1028.848 + ], + "priority": 8, + "parents": [ + 56740 + ], + "children": [], + "area": 233398.160732, + "iscrowd": 0, + "segmentation": [], + "text": "In our study, streptococcal strains were isolated from different body regions. All\nstrains were Gram positive cocci in chains and the oxidase and catalase were found\nnegative. All isolates were VP positive, PYR negative and did not hydrolyse\nhippurat; two strains were urease positive. CAMP test for all strains were applied for\ncontrol purposes and all strains were found to be CAMP negative. All the strains were\nfound to hydrolyse arginine. When evaluated in terms of hydrolysis of esculin, 57\nstrains were esculin positive and 43 strains were negative. All strains was found to be\nsusceptible to vancomycin, ceftriaxone, cefepime, cefotaxime, levofloxacin, linezolid\nantibiotics. 16% of strains (10 S.anginosus, 4 S.constellatus) were found to be\nresistant to erythromycin. 6% of the strains (5 S.anginosus, 3 S.constellatus) were\nresistant to clindamycin and 5% (3 S.constellatus ve 2 S.anginosus) of the strains\nwere found to be resistant to tetracycline. Chloramphenicol resistance rate was\ndetermined to be 1%.Ampicillin and penicillin resistance were detected by the E-test\nmethod, and | strain was found to be resistant to both ampicillin and penicillin.\nMoreover two S.anginosus strains were found to be intermediate susceptible to\nampicillin. According to PCR results of 100 isolates, 56 were identified\nas S.anginosus and 8 were identified as S.intermedius." + }, + { + "id": 56741, + "strid": "1ed0887b-07a0-472d-a717-6473ce021c17", + "image_id": 202737, + "image_name": "119166.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 68.144, + 4063.89, + 1694.633, + 952.7260000000001 + ], + "priority": 9, + "parents": [ + 56740 + ], + "children": [ + 56742 + ], + "area": 276929.72016, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 56742, + "strid": "f9a4291e-8552-4c13-93b5-467a7f132b05", + "image_id": 202737, + "image_name": "119166.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 136.709, + 3974.776, + 1151.995, + 60.17900000000009 + ], + "priority": 10, + "parents": [ + 56741 + ], + "children": [], + "area": 543387.652184, + "iscrowd": 0, + "segmentation": [], + "text": "Figurel. Streptococcus milleri group colony morphology" + }, + { + "id": 56743, + "strid": "ffbb7c5a-1f5b-4844-9d37-1b117587cfe7", + "image_id": 202737, + "image_name": "119166.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2039.13, + 673.153, + 1074.2849999999999, + 309.45000000000005 + ], + "priority": 11, + "parents": [ + 56740 + ], + "children": [ + 56752 + ], + "area": 1372646.47689, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 56752, + "strid": "91966527-2177-40fd-b7af-58634758095e", + "image_id": 202737, + "image_name": "119166.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2032.303, + 619.631, + 932.3700000000001, + 52.03800000000001 + ], + "priority": 12, + "parents": [ + 56743 + ], + "children": [], + "area": 1259277.940193, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1: Hemolytic characterization of strains" + }, + { + "id": 56744, + "strid": "9066c69f-153c-48bc-8bfc-28b4fb04ded6", + "image_id": 202737, + "image_name": "119166.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2076.089, + 1081.497, + 1047.549, + 392.9649999999999 + ], + "priority": 13, + "parents": [ + 56740 + ], + "children": [ + 56753 + ], + "area": 2245284.025233, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 56753, + "strid": "c41c96de-07c9-4f88-9b88-d5dab023b647", + "image_id": 202737, + "image_name": "119166.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2043.178, + 1019.139, + 710.1200000000001, + 53.49300000000005 + ], + "priority": 14, + "parents": [ + 56744 + ], + "children": [], + "area": 2082282.3837420002, + "iscrowd": 0, + "segmentation": [], + "text": "Table 2. Lancefield Group antigens" + }, + { + "id": 56745, + "strid": "1afd3278-2b2d-4556-b10d-6d3b3f44dfba", + "image_id": 202737, + "image_name": "119166.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2096.016, + 1582.369, + 1010.5900000000001, + 528.1919999999998 + ], + "priority": 15, + "parents": [ + 56740 + ], + "children": [ + 56754 + ], + "area": 3316670.741904, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 56754, + "strid": "44badf57-aae3-4364-ad42-2a52ff0c112a", + "image_id": 202737, + "image_name": "119166.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2030.749, + 1523.553, + 575.6540000000002, + 53.22499999999991 + ], + "priority": 16, + "parents": [ + 56745 + ], + "children": [], + "area": 3093953.7311970005, + "iscrowd": 0, + "segmentation": [], + "text": "Table 3. Sugar Fermentation" + }, + { + "id": 56746, + "strid": "05af904b-8139-4c11-870c-ebe270f78b55", + "image_id": 202737, + "image_name": "119166.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2090.247, + 2208.872, + 1001.4780000000001, + 739.3690000000001 + ], + "priority": 17, + "parents": [ + 56740 + ], + "children": [ + 56755 + ], + "area": 4617088.071384, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 56755, + "strid": "c20c8c04-a946-4533-b38e-97db31000c0a", + "image_id": 202737, + "image_name": "119166.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2031.933, + 2158.918, + 609.732, + 48.17599999999993 + ], + "priority": 18, + "parents": [ + 56746 + ], + "children": [], + "area": 4386776.728494001, + "iscrowd": 0, + "segmentation": [], + "text": "Table 4. API 20 Strep Results" + }, + { + "id": 56747, + "strid": "bc159ab1-3eb3-4845-8811-c0e317f54a77", + "image_id": 202737, + "image_name": "119166.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1936.32, + 2993.905, + 1527.836, + 229.41100000000006 + ], + "priority": 19, + "parents": [ + 56740 + ], + "children": [], + "area": 5797158.129600001, + "iscrowd": 0, + "segmentation": [], + "text": "According to PCR results of 100 isolates, 56 were identified as\nS.anginosus and 8 were identified as S.intermedius. No band was detected\nfor 12 strains. For these 12 strains, both multiplex and monoplex PCR was\ncarried out." + }, + { + "id": 56748, + "strid": "bbf65595-02ee-46e7-bf48-d195dc432450", + "image_id": 202737, + "image_name": "119166.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1888.383, + 3335.869, + 1561.1010000000003, + 665.4389999999999 + ], + "priority": 20, + "parents": [ + 56740 + ], + "children": [ + 56749 + ], + "area": 6299398.309827001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 56749, + "strid": "31fe8850-82a4-406f-97dd-102f69f5dc48", + "image_id": 202737, + "image_name": "119166.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1963.8, + 3280.776, + 419.72, + 55.09299999999985 + ], + "priority": 21, + "parents": [ + 56748 + ], + "children": [], + "area": 6442787.908799999, + "iscrowd": 0, + "segmentation": [], + "text": "Figure2. PCR bands" + }, + { + "id": 56750, + "strid": "3f270a60-6aba-4f06-99ac-856442daa0c8", + "image_id": 202737, + "image_name": "119166.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1896.23, + 4053.771, + 395.8319999999999, + 49.732000000000426 + ], + "priority": 22, + "parents": [ + 56756 + ], + "children": [ + 56751 + ], + "area": 7686882.18333, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 56751, + "strid": "383bec92-784d-41ba-b00f-df9601ea33d1", + "image_id": 202737, + "image_name": "119166.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1829.264, + 4122.378, + 1613.9039999999998, + 352.96100000000024 + ], + "priority": 23, + "parents": [ + 56750 + ], + "children": [], + "area": 7540917.669791999, + "iscrowd": 0, + "segmentation": [], + "text": "In our study it was determined that biochemical identification scheme is not\nsatisfactory for Streptococcus milleri group. No emergence antibiotic resistance\nwas determined. However, MIC should be investigated for strains isolated from\nsterile body parts. Commercially available biochemical kits are inadequent and\nidentification should be supported with molecular methods. This study. is\nthought to be a backbone for other studies in the future." + }, + { + "id": 183927, + "strid": "923153cc-1888-42ed-b1a0-502501fe849b", + "image_id": 207677, + "image_name": "8583.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 184.64, + 77.02, + 237.46000000000004, + 237.47000000000003 + ], + "priority": -1, + "parents": [], + "children": [ + 183906, + 183908, + 183903, + 183904, + 183905, + 183907, + 183900, + 183901, + 183902 + ], + "area": 14220.972799999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 183900, + "strid": "0e24b2b8-e8fd-47fc-95f3-fe285660942d", + "image_id": 207677, + "image_name": "8583.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 496.298, + 96.68, + 3809.0370000000003, + 96.894 + ], + "priority": 1, + "parents": [ + 183927 + ], + "children": [], + "area": 47982.09064, + "iscrowd": 0, + "segmentation": [], + "text": "Economic Evaluation of Fungal Meningitis Outbreak in New River Health District" + }, + { + "id": 183901, + "strid": "a0cc9978-0d0c-44a3-b2d0-2125a0536b5e", + "image_id": 207677, + "image_name": "8583.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 688.995, + 217.171, + 3420.5290000000005, + 326.7010000000001 + ], + "priority": 2, + "parents": [ + 183927 + ], + "children": [], + "area": 149629.733145, + "iscrowd": 0, + "segmentation": [], + "text": "'¢Nargesalsadat Dorratoltaj, ‘Paige Bordwine, **Margaret O’Dell, “Kerry Redican, 2° Thomas Kerkering, 7Kaja Abbas\n\n| ‘Biomedical and Veterinary Sciences, 7Population Health Sciences, Virginia Tech i\nalech 3Infectious Diseases, Virginia Tech Carilion School of Medicine\n4New River Health District, Virginia Department of Health w" + }, + { + "id": 183902, + "strid": "86763998-67a6-4b82-b778-2555ea4eefa6", + "image_id": 207677, + "image_name": "8583.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 465.191, + 623.081, + 346.883, + 66.56899999999996 + ], + "priority": 3, + "parents": [ + 183927 + ], + "children": [ + 183909 + ], + "area": 289851.673471, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 183909, + "strid": "7a30ce6e-bc63-4334-8c38-cef515e17773", + "image_id": 207677, + "image_name": "8583.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 113.447, + 731.089, + 1053.987, + 1496.909 + ], + "priority": 4, + "parents": [ + 183902 + ], + "children": [], + "area": 82939.85378300001, + "iscrowd": 0, + "segmentation": [], + "text": "Objective: The objective of this study is to conduct an economic\nevaluation from the local public health department perspective of the\nfungal meningitis outbreak response in New River Valley of Virginia.\nBackground: The multi-state fungal meningitis outbreak started in\nSeptember 2012 in Tennessee. The immediate cause of the outbreak\nwas injection of contaminated lots of methylprednisolone acetate used\nin epidural spinal injections. Roanoke and New River Valley were the\nepicenter of this outbreak in Virginia, with two clinical centers having\nadministered the contaminated injections to their patients.\n\nMethods: New River Health District (Virginia Department of Health),\nthe local public health department of New River Valley, deployed its\nresources extensively to control the local impact of the outbreak,\nstarting in October 2012. Public health personnel, in collaboration with\nClinicians in local hospitals, followed up the exposed patients for 6\nmonths, and provided appropriate treatment including lab tests and\nhospitalizations. The health department continued the outbreak\ninvestigation until March 2013 to ascertain that all possible cases were\nidentified and treated. None of the followed-up patients met the case\ndefinition, as defined by CDC.\n\nResults: Based on preliminary analysis, the local health department\nexpenditure was estimated to be $30,493 and 100.52 years of disability\nadjusted life years were averted among the patients, for an incremental\ncost-effectiveness ratio of $303 per disability adjusted life year averted.\nDiscussion: The estimated incremental cost effectiveness ratio assists\nthe local health department to both prioritize and allocate limited public\nhealth resources. Our future work will extend the cost-effectiveness\nanalysis to include the clinical perspective, in addition to the local\nhealth department perspective." + }, + { + "id": 183903, + "strid": "794253ed-2c46-474c-916b-09dadf76da55", + "image_id": 207677, + "image_name": "8583.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1690.172, + 652.876, + 484.1790000000001, + 65.29399999999998 + ], + "priority": 5, + "parents": [ + 183927 + ], + "children": [ + 183912 + ], + "area": 1103472.734672, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 183912, + "strid": "3cd6a3ca-7e50-415e-bf31-a67abbb1ffdd", + "image_id": 207677, + "image_name": "8583.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1298.348, + 790.399, + 1444.19, + 684.071 + ], + "priority": 6, + "parents": [ + 183903 + ], + "children": [], + "area": 1026212.9608519999, + "iscrowd": 0, + "segmentation": [], + "text": "In september 2012, Tennessee department of health, culture confirmed cases of Aspergillus\nFumigatus Meningitis following Epidural Steroid Injection (ESI) [1]. Further studies observed and\nconfirmed contamination of preserved free Methylprednisolone Acetate lots which had been used\nfor ESI during July 30 to Sep 18, 2013. Contaminated lots had been produced in a compounding\npharmacy in Massachusetts [2]. Healthcare facilities in 23 states received contaminated lots.\nMultistate outbreak of fungal meningitis confirmed 751 cases from 20 states, including 64 deaths.\nIn this outbreak, Virginia reported the fourth most cases nationally with 54 cases and 5 deaths.\nLocal health departments played a key role in disease surveillance and case reporting, plus\nrefering probable cases to local health facilities for further services and hospitalization. This\noutbreak investigation required collaboration of different organizations. Individuals were in contact\nwith their local health department and health facility, and local facilities were in contact with state\nand federal organizations. Economic evaluation provides a measure to be able to compare and\nvisualize the role of each organization in this outbreak investigation." + }, + { + "id": 183907, + "strid": "068933d6-ce37-4849-88d9-a8df43954f45", + "image_id": 207677, + "image_name": "8583.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1792.303, + 1640.698, + 337.5640000000001, + 66.1110000000001 + ], + "priority": 7, + "parents": [ + 183927 + ], + "children": [ + 183913, + 183918, + 183914, + 183917, + 183916 + ], + "area": 2940627.947494, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 183913, + "strid": "b2474250-e70f-4a95-9110-a7a57e65edf0", + "image_id": 207677, + "image_name": "8583.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1308.69, + 1801.054, + 1389.841, + 142.4960000000001 + ], + "priority": 8, + "parents": [ + 183907 + ], + "children": [], + "area": 2357021.3592600003, + "iscrowd": 0, + "segmentation": [], + "text": "New River Valley was among 11 health districts in virginia with exposed residents. There were\n94 exposed residents who needed follow up for further assistance. Local health department\nhad a standard surveillance system to follow-up with patients." + }, + { + "id": 183914, + "strid": "50b8b989-4dba-4a20-acea-8bd9ebeb1b92", + "image_id": 207677, + "image_name": "8583.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1398.928, + 2056.693, + 1366.2549999999999, + 436.3960000000002 + ], + "priority": 9, + "parents": [ + 183907 + ], + "children": [ + 183915 + ], + "area": 2877165.4251040006, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 183915, + "strid": "3de2e5ea-6511-4286-bb55-9622fc8f5240", + "image_id": 207677, + "image_name": "8583.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1724.988, + 2578.826, + 589.914, + 34.052000000000135 + ], + "priority": 10, + "parents": [ + 183914 + ], + "children": [], + "area": 4448443.904088, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1 - Active Surveillance Algorithm" + }, + { + "id": 183916, + "strid": "f7fbf0fe-edac-4f5e-9cf6-40aa62331048", + "image_id": 207677, + "image_name": "8583.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1334.375, + 2771.784, + 1316.2960000000003, + 87.38299999999981 + ], + "priority": 11, + "parents": [ + 183907 + ], + "children": [], + "area": 3698599.2750000004, + "iscrowd": 0, + "segmentation": [], + "text": "To conduct the economic evaluation of outbreak control, we collected data related to time\nand costs associated with each task in the local health department." + }, + { + "id": 183917, + "strid": "a3686f39-3c30-47df-b463-288bc92e5ed4", + "image_id": 207677, + "image_name": "8583.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1371.955, + 2878.952, + 453.1100000000001, + 472.0770000000002 + ], + "priority": 12, + "parents": [ + 183907 + ], + "children": [ + 183920 + ], + "area": 3949792.5911600003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 183920, + "strid": "9f9f7a57-2414-40f9-b18f-a2767dc85b45", + "image_id": 207677, + "image_name": "8583.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1329.569, + 3363.075, + 591.2759999999998, + 19.673999999999978 + ], + "priority": 13, + "parents": [ + 183917 + ], + "children": [], + "area": 4471440.264675, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1 - Cost of outbreak investigation at New River Health District" + }, + { + "id": 183918, + "strid": "a20d8843-fe78-4757-81fd-5a8cd320e1ef", + "image_id": 207677, + "image_name": "8583.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2095.492, + 2937.329, + 558.5529999999999, + 336.7890000000002 + ], + "priority": 14, + "parents": [ + 183907 + ], + "children": [ + 183919 + ], + "area": 6155149.420868001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 183919, + "strid": "9845e055-86c8-4c64-8e88-b0a770dd7eab", + "image_id": 207677, + "image_name": "8583.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2032.891, + 3354.243, + 709.2379999999998, + 19.804999999999836 + ], + "priority": 15, + "parents": [ + 183918 + ], + "children": [], + "area": 6818810.406513, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2 - Proportional Cost of outbreak investigation at New River Health District" + }, + { + "id": 183904, + "strid": "f25d6394-b375-4f51-87f7-94f26357518e", + "image_id": 207677, + "image_name": "8583.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3634.544, + 624.218, + 296.1460000000002, + 65.43700000000001 + ], + "priority": 16, + "parents": [ + 183927 + ], + "children": [ + 183924, + 183921, + 183922 + ], + "area": 2268747.7865919997, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 183921, + "strid": "d8bc9e12-98df-4ff3-b824-fb93f0b94e42", + "image_id": 207677, + "image_name": "8583.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2925.519, + 791.085, + 1734.7899999999995, + 954.914 + ], + "priority": 17, + "parents": [ + 183904 + ], + "children": [], + "area": 2314334.198115, + "iscrowd": 0, + "segmentation": [], + "text": "Costs and effectiveness associated with the outbreak investigation are compared to no intervention.\n\nCosts: Total direct cost for the local health department is computed based on total hours spent in the outbreak\nresponse, and hourly cost of corresponding personnel. We estimated that $30,492 were spent by the local health\ndepartment to control the outbreak.\n\nEffectiveness: Effectiveness of the outbreak response is estimated at 100.52 DALYs (disability adjusted life years)\naverted. Since none of the exposed New River Valley residents met the CDC case definition, potential disability\nadjusted averted life years calculated were based on the ratio of confirmed cases among exposed patients in Virginia.\nIncremental Cost-Effectiveness Ratio (ICER): The incremental cost-effectiveness ratios of the fungal meningitis\noutbreak response is estimated at $303/DALY averted from the local public health department perspective.\n\nFungal meningitis outbreak response from the local public health department perspective:\nCosts = $30,492\nEffectiveness = YLL + YLD=DALY = 100.52 DALYS\n\nCOS8tnewintervention — COS8teontrol\nEf fectivenessnowintervention — Ef fectivenesscontrot\n\n \n\nICER\n\n \n\nICER = $303 per DALY averted" + }, + { + "id": 183922, + "strid": "5d38af9a-d2c4-474c-8ab5-dec88ab55a8f", + "image_id": 207677, + "image_name": "8583.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2967.831, + 1930.721, + 853.25, + 802.3620000000001 + ], + "priority": 18, + "parents": [ + 183904 + ], + "children": [ + 183923 + ], + "area": 5730053.636151, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 183923, + "strid": "2c5ba5cf-8d35-4353-abcf-88e247bbd32b", + "image_id": 207677, + "image_name": "8583.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 3239.635, + 2791.675, + 233.56500000000005, + 16.253000000000156 + ], + "priority": 19, + "parents": [ + 183922 + ], + "children": [], + "area": 9044008.038625002, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 183924, + "strid": "278d14d5-dcbc-4c82-83ad-ef10505cd1ea", + "image_id": 207677, + "image_name": "8583.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3919.354, + 2094.074, + 715.172, + 500.9499999999998 + ], + "priority": 20, + "parents": [ + 183904 + ], + "children": [ + 183925 + ], + "area": 8207417.308196, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 183925, + "strid": "17cd0ad1-e8f0-4056-a437-6875d09bb329", + "image_id": 207677, + "image_name": "8583.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 3902.656, + 2616.16, + 727.8850000000002, + 20.496999999999844 + ], + "priority": 21, + "parents": [ + 183924 + ], + "children": [], + "area": 10209972.52096, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3 - Cost-effectiveness analysis of the fungal meningitis outbreak investigation" + }, + { + "id": 183908, + "strid": "059b7c56-3e1e-40ac-a26b-cb9b3c81754a", + "image_id": 207677, + "image_name": "8583.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3561.91, + 3010.224, + 439.5369999999998, + 66.42900000000009 + ], + "priority": 22, + "parents": [ + 183927 + ], + "children": [ + 183926 + ], + "area": 10722146.967840001, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion" + }, + { + "id": 183926, + "strid": "f750107f-f16e-45db-9c94-e80516ed83d5", + "image_id": 207677, + "image_name": "8583.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2923.332, + 3132.0, + 1651.766, + 305.6350000000002 + ], + "priority": 23, + "parents": [ + 183908 + ], + "children": [], + "area": 9155875.824, + "iscrowd": 0, + "segmentation": [], + "text": "Based on preliminary results, we estimated the incremental cost-effectiveness ratio of the New River Health\nDistrict public health response to the fungal meningitis outbreak in New River Valley at $303 per disability\nadjusted life year averted. Probabilistic sensitivity analysis will be added to the study. The estimated incremental\ncost effectiveness ratio assists the local health department to both prioritize and allocate limited public health\nresources. We will extend this study to include the clinical response perspective, by adding the costs associated\n\nwith the patients’ clinical care." + }, + { + "id": 183906, + "strid": "a4645c67-0982-4c30-8bee-6e562b12962c", + "image_id": 207677, + "image_name": "8583.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 244.13, + 3100.344, + 784.343, + 82.68600000000015 + ], + "priority": 24, + "parents": [ + 183927 + ], + "children": [ + 183911 + ], + "area": 756886.98072, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements" + }, + { + "id": 183911, + "strid": "a797c73e-4584-42f7-9b52-0c6a7c47fa89", + "image_id": 207677, + "image_name": "8583.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 115.597, + 3211.482, + 989.3320000000001, + 140.09299999999985 + ], + "priority": 25, + "parents": [ + 183906 + ], + "children": [], + "area": 371237.684754, + "iscrowd": 0, + "segmentation": [], + "text": "We thank the Virginia Tech Institutional Review Board for ethical\nreview and approval of this study. KA is supported (in part) by the\n\nNational Coordinating Center for Public Health Services & Systems\nResearch. eee" + }, + { + "id": 183905, + "strid": "6f0445ad-0164-459d-8911-5b3f3e130da7", + "image_id": 207677, + "image_name": "8583.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 418.386, + 2330.186, + 445.694, + 65.78900000000021 + ], + "priority": 26, + "parents": [ + 183927 + ], + "children": [ + 183910 + ], + "area": 974917.1997960001, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 183910, + "strid": "dc34413c-9a69-4d29-a0f2-ea3281d081d1", + "image_id": 207677, + "image_name": "8583.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 106.62, + 2469.055, + 1037.3830000000003, + 521.5729999999999 + ], + "priority": 27, + "parents": [ + 183905 + ], + "children": [], + "area": 263250.6441, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 106691, + "strid": "30e30c1f-7759-488b-a319-88babc5c0a53", + "image_id": 204629, + "image_name": "12575.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 4.25, + 15.45, + 22.16, + 109.33 + ], + "priority": -1, + "parents": [], + "children": [ + 106672, + 106670, + 106673, + 106674, + 106668, + 106671, + 106681, + 106669 + ], + "area": 65.6625, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 106668, + "strid": "ccf08ea4-04f4-43d4-8efd-33937665ab30", + "image_id": 204629, + "image_name": "12575.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 31.62, + 14.429, + 458.209, + 120.946 + ], + "priority": 1, + "parents": [ + 106691 + ], + "children": [], + "area": 456.24498, + "iscrowd": 0, + "segmentation": [], + "text": "Neonatal Tetanus in Central\nAfrican Republic: A neglected\n\ntragedy" + }, + { + "id": 106669, + "strid": "1e914e52-7f77-4b79-b21a-b1dd48ef729b", + "image_id": 204629, + "image_name": "12575.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 33.084, + 150.72, + 541.28, + 59.95000000000002 + ], + "priority": 2, + "parents": [ + 106691 + ], + "children": [], + "area": 4986.420480000001, + "iscrowd": 0, + "segmentation": [], + "text": "Papadimitriou V'?, Ciglenecki I', Gonzalez A', Macher E', Martinez Garcia D', Albela\nMiranda M'.\n\n‘ Médecins Sans Frontiéres (OCG), Geneva, Swizertand, ? Hépitaux Universitaires Genéve, Geneva, Switzerland" + }, + { + "id": 106670, + "strid": "97899537-9c5a-4da9-8e2b-8184dc61cb35", + "image_id": 204629, + "image_name": "12575.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 37.026, + 237.852, + 101.90899999999999, + 19.133999999999986 + ], + "priority": 3, + "parents": [ + 106691 + ], + "children": [ + 106675, + 106677, + 106676, + 106678, + 106689, + 106688 + ], + "area": 8806.708152000001, + "iscrowd": 0, + "segmentation": [], + "text": "Background" + }, + { + "id": 106675, + "strid": "670cc867-731f-4dc0-b5dd-405e9acfaf9d", + "image_id": 204629, + "image_name": "12575.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 36.348, + 271.639, + 458.678, + 90.56700000000001 + ], + "priority": 4, + "parents": [ + 106670 + ], + "children": [], + "area": 9873.534372, + "iscrowd": 0, + "segmentation": [], + "text": "Neonatal tetanus Is a life threatening condition caused by contamination of the umbilical cord In\ninfants born to mothers with inadequate immunization against tetanus.\n\nIn 1998 UNICEF, WHO and UNFPA launched the Maternal and Neonatal Tetanus Elimination\n(MNTE) Iniatve. Since then, Maternal and Neonatal Tetanus has been eliminated in 44 counties.\nUnfortunatly, by December 2017, 15 counties ell reported neonatal tetanus cases. Central Arcan\nRepublic (CAR) is among them." + }, + { + "id": 106676, + "strid": "25d3af66-71cd-4b24-80cd-e9e0ede5eb93", + "image_id": 204629, + "image_name": "12575.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 62.454, + 373.19, + 437.337, + 17.745000000000005 + ], + "priority": 5, + "parents": [ + 106670 + ], + "children": [], + "area": 23307.20826, + "iscrowd": 0, + "segmentation": [], + "text": "Case fatality rate can be up to 90% without treatment" + }, + { + "id": 106688, + "strid": "9cfc1c63-8548-4afc-a8c5-0b692c8562ac", + "image_id": 204629, + "image_name": "12575.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 47.665, + 398.793, + 186.722, + 152.293 + ], + "priority": 6, + "parents": [ + 106670 + ], + "children": [ + 106685 + ], + "area": 19008.468345, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 106685, + "strid": "8c5f283e-6551-4c7a-ad9e-24c9ba39c70e", + "image_id": 204629, + "image_name": "12575.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 45.302, + 551.107, + 148.77, + 9.630999999999972 + ], + "priority": 7, + "parents": [ + 106688 + ], + "children": [], + "area": 24966.249313999997, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 106677, + "strid": "0995b38b-5fd7-4ead-8648-441adfc67664", + "image_id": 204629, + "image_name": "12575.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 242.92, + 407.976, + 242.879, + 128.73699999999997 + ], + "priority": 8, + "parents": [ + 106670 + ], + "children": [], + "area": 99105.52992, + "iscrowd": 0, + "segmentation": [], + "text": "CAR Is one of the poorest countries in the world anc\nithas been suffering a violent confit since 2012,\ndisplacing more than 1.1 millon people. No numbers\nor estimations have been published regarding the\nfatalities.\n\nMédecins Sans Frontiéres (MSF) has boon\nsupporting the Pediatrics and Neonatology services\nof the Hépital Universitaie de Berbera (HRUB), in\nthe west part of the country, since 2014." + }, + { + "id": 106689, + "strid": "05c67574-3d62-4e66-b321-34fc60ccd9bc", + "image_id": 204629, + "image_name": "12575.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 509.679, + 268.477, + 283.153, + 181.78300000000002 + ], + "priority": 9, + "parents": [ + 106670 + ], + "children": [ + 106683 + ], + "area": 136837.088883, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 106683, + "strid": "dd6336b2-1386-48b4-9e14-e65147446e34", + "image_id": 204629, + "image_name": "12575.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 508.276, + 451.527, + 258.276, + 31.47199999999998 + ], + "priority": 10, + "parents": [ + 106689 + ], + "children": [], + "area": 229500.337452, + "iscrowd": 0, + "segmentation": [], + "text": "EE Eee REE nee eet\nThese eae “Ido nner sow ho ous, dbp 3,700\nraat, pour religion. You enffes that to onagh romee" + }, + { + "id": 106678, + "strid": "a73bab1f-cf1f-4f96-be52-b4ae10e48779", + "image_id": 204629, + "image_name": "12575.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 508.53, + 492.305, + 276.078, + 38.65699999999998 + ], + "priority": 11, + "parents": [ + 106670 + ], + "children": [], + "area": 250351.86164999998, + "iscrowd": 0, + "segmentation": [], + "text": "This analysis is based on the neonatal tetanus cases that\nwe have managed inthe Neonatology ward from the start of\nour activities until the closure of the project." + }, + { + "id": 106671, + "strid": "9482f648-0e5a-4be5-bc84-f89a24f3d21b", + "image_id": 204629, + "image_name": "12575.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 36.925, + 578.749, + 72.493, + 15.879999999999995 + ], + "priority": 12, + "parents": [ + 106691 + ], + "children": [ + 106679 + ], + "area": 21370.306825, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 106679, + "strid": "e1aa584a-412b-458e-87e3-92679161a673", + "image_id": 204629, + "image_name": "12575.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 31.897, + 607.305, + 177.676, + 238.82600000000002 + ], + "priority": 13, + "parents": [ + 106671 + ], + "children": [], + "area": 19371.207584999996, + "iscrowd": 0, + "segmentation": [], + "text": "Design: Retrospective review of the\nindividual patent fles\n\nPopulation: All suspected casos of\nneonatal tetanus admitted to the\nHRUB\n\nSite: MSF supported hospital ~ HRUB\nPeriod: Between March 2014 and\nAugust 2017.\n\nProcedure: Severiy was graded\naccording to Dakar score , which\nincludes lactors such as incubation\nperiod, period of onset, entry site,\nspasms, fever and tachycardia forte\ncalculation, The descriptive analysis\nwas followed by a logistic regression\nanalysie used to assess potetlal\naseacialions between the risk factors\nand mortality." + }, + { + "id": 106672, + "strid": "14d0041c-4dfe-4e5a-a6d9-de16f62897d0", + "image_id": 204629, + "image_name": "12575.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 226.659, + 579.073, + 62.774, + 15.525999999999954 + ], + "priority": 14, + "parents": [ + 106691 + ], + "children": [ + 106682, + 106690, + 106686 + ], + "area": 131252.107107, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 106690, + "strid": "6aae75c5-d789-4621-af4d-de00cab56345", + "image_id": 204629, + "image_name": "12575.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 221.704, + 607.754, + 353.218, + 220.64300000000003 + ], + "priority": 15, + "parents": [ + 106672 + ], + "children": [ + 106684 + ], + "area": 134741.492816, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 106684, + "strid": "49d7e1fb-0068-4fe5-a05a-c98efb41a983", + "image_id": 204629, + "image_name": "12575.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 283.752, + 830.572, + 222.38600000000002, + 9.908999999999992 + ], + "priority": 16, + "parents": [ + 106690 + ], + "children": [], + "area": 235676.466144, + "iscrowd": 0, + "segmentation": [], + "text": "Number of admissions per month of meoneal cases in the HRUB" + }, + { + "id": 106686, + "strid": "5282c147-22b6-4401-9ed8-3d13ca9f04fd", + "image_id": 204629, + "image_name": "12575.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 585.057, + 611.902, + 214.02300000000002, + 154.265 + ], + "priority": 17, + "parents": [ + 106672 + ], + "children": [], + "area": 357997.548414, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 106682, + "strid": "9f9c070b-908d-4859-bae8-8d8e52d89439", + "image_id": 204629, + "image_name": "12575.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 614.408, + 773.815, + 185.938, + 125.69200000000001 + ], + "priority": 18, + "parents": [ + 106672 + ], + "children": [], + "area": 475438.12652000005, + "iscrowd": 0, + "segmentation": [], + "text": "This is one of the\nbiggest cohort of\nneonatal tetanus\npatients that has been\nreported. And this is\nstill happening today" + }, + { + "id": 106673, + "strid": "d4cbf81c-ce67-40fc-b989-822a08e2b8f2", + "image_id": 204629, + "image_name": "12575.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 36.433, + 857.949, + 166.457, + 15.860000000000014 + ], + "priority": 19, + "parents": [ + 106691 + ], + "children": [ + 106680 + ], + "area": 31257.655917, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 106680, + "strid": "6233e97c-c59b-4cad-8b0d-fa1ab1730726", + "image_id": 204629, + "image_name": "12575.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 32.009, + 893.67, + 496.8929999999999, + 13.085000000000036 + ], + "priority": 20, + "parents": [ + 106673 + ], + "children": [], + "area": 28605.48303, + "iscrowd": 0, + "segmentation": [], + "text": "MSF conducted a 3-round mass tetanus vaccination campaign targetting women in reproductive age" + }, + { + "id": 106674, + "strid": "ba27d037-2d91-4ae0-8952-006afb2ac2e3", + "image_id": 204629, + "image_name": "12575.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 37.463, + 931.44, + 105.037, + 15.258000000000038 + ], + "priority": 21, + "parents": [ + 106691 + ], + "children": [ + 106687 + ], + "area": 34894.536720000004, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 106687, + "strid": "67eea2ba-ff87-46fa-b6d8-6eccc1db78ae", + "image_id": 204629, + "image_name": "12575.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 32.178, + 961.947, + 551.828, + 165.52499999999998 + ], + "priority": 22, + "parents": [ + 106674 + ], + "children": [], + "area": 30953.530565999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 106681, + "strid": "8551b8b6-5399-469f-ba9c-037ba537b79c", + "image_id": 204629, + "image_name": "12575.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 609.694, + 941.109, + 187.78499999999997, + 87.80200000000002 + ], + "priority": 23, + "parents": [ + 106691 + ], + "children": [], + "area": 573788.510646, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements\n\nWe would lke to thank the MSF teams\nin Berberati as well a al the heath\nauthorities who are doing thet best 10\nmanage ths situation among many\nother problems that the country is facing" + }, + { + "id": 191556, + "strid": "c14f1f50-c68f-4cdf-a5cd-4007db4a0d58", + "image_id": 207981, + "image_name": "9193.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 10.92, + 12.73, + 45.25, + 84.86 + ], + "priority": -1, + "parents": [], + "children": [ + 191546, + 191544, + 191545, + 191552, + 191551, + 191542, + 191541, + 191543, + 191557 + ], + "area": 139.01160000000002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 191541, + "strid": "8d13fe3c-f357-4ab1-8cf4-037e30353f44", + "image_id": 207981, + "image_name": "9193.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 63.768, + 42.038, + 695.764, + 48.71300000000001 + ], + "priority": 1, + "parents": [ + 191556 + ], + "children": [], + "area": 2680.6791839999996, + "iscrowd": 0, + "segmentation": [], + "text": "LONGITUDINAL DATA OF PERITONEAL MEMBRANE FUNCTION\nBASED ON TWO-IN-ONE MODIFIED PET" + }, + { + "id": 191542, + "strid": "f6936c83-bb4c-4308-a2af-23927d24d10a", + "image_id": 207981, + "image_name": "9193.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 35.724, + 137.088, + 730.942, + 45.522999999999996 + ], + "priority": 2, + "parents": [ + 191556 + ], + "children": [], + "area": 4897.331711999999, + "iscrowd": 0, + "segmentation": [], + "text": "so eae a eee ee ee ne\n\nECE" + }, + { + "id": 191543, + "strid": "9dff3e75-1c4b-4f04-beb0-16edb802684c", + "image_id": 207981, + "image_name": "9193.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 101.241, + 217.98, + 105.57699999999998, + 15.522999999999996 + ], + "priority": 3, + "parents": [ + 191556 + ], + "children": [ + 191547 + ], + "area": 22068.513179999998, + "iscrowd": 0, + "segmentation": [], + "text": "OBJECTIVES" + }, + { + "id": 191547, + "strid": "c8ceef96-7c7f-4d1b-9c09-079cf0046d35", + "image_id": 207981, + "image_name": "9193.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 36.732, + 257.365, + 239.35300000000004, + 225.39300000000003 + ], + "priority": 4, + "parents": [ + 191543 + ], + "children": [], + "area": 9453.53118, + "iscrowd": 0, + "segmentation": [], + "text": "Modified PET (use of 3.86% glucose\ndialysate instead of 2.27%) and temporal\ndrainage after 60 min and final drainage\nafter 240min (called two-in-one protocol\nof modified PET) gives information about\nsodium sieving, free water transport\n(FWT) and ultrafitration failure(UFF).\nLongitudinal data using this specific PET\nare sporadic. Aim of our study was a)\nlongitudinal follow-up of the membrane\nfunction using this PET b) possible\nassociations between membrane\ncharacteristics and clinical data)\nevaluation of UFF and association with\nclinical characteristics." + }, + { + "id": 191544, + "strid": "033acc27-f332-4dfb-be51-c664242a008a", + "image_id": 207981, + "image_name": "9193.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 504.289, + 215.854, + 85.05999999999995, + 15.174000000000007 + ], + "priority": 5, + "parents": [ + 191556 + ], + "children": [ + 191548 + ], + "area": 108852.797806, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 191548, + "strid": "04a8497d-934e-4d41-b118-d338e49561ad", + "image_id": 207981, + "image_name": "9193.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 323.36, + 267.16, + 434.698, + 228.12100000000004 + ], + "priority": 6, + "parents": [ + 191544 + ], + "children": [], + "area": 86388.85760000002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 191551, + "strid": "05baef87-7379-4439-a2b6-64bdade1967b", + "image_id": 207981, + "image_name": "9193.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 99.535, + 584.135, + 233.465, + 141.30999999999995 + ], + "priority": 7, + "parents": [ + 191556 + ], + "children": [ + 191554 + ], + "area": 58141.877225, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 191554, + "strid": "4036f601-bff2-4e78-9882-7a40cd92947e", + "image_id": 207981, + "image_name": "9193.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 46.462, + 726.206, + 159.642, + 8.023000000000025 + ], + "priority": 8, + "parents": [ + 191551 + ], + "children": [], + "area": 33740.983172, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 191552, + "strid": "27f7e157-e809-47d4-af60-a23ceb99af7c", + "image_id": 207981, + "image_name": "9193.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 100.997, + 736.198, + 236.735, + 112.68700000000001 + ], + "priority": 9, + "parents": [ + 191556 + ], + "children": [ + 191555 + ], + "area": 74353.789406, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 191555, + "strid": "d973d16d-a443-42b9-a746-07aca9556e9e", + "image_id": 207981, + "image_name": "9193.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 44.086, + 855.251, + 234.397, + 7.753000000000043 + ], + "priority": 10, + "parents": [ + 191552 + ], + "children": [], + "area": 37704.595585999996, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 191545, + "strid": "650b3193-d8e3-4160-ae0f-86127063cc69", + "image_id": 207981, + "image_name": "9193.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 545.431, + 554.394, + 75.68200000000002, + 15.743000000000052 + ], + "priority": 11, + "parents": [ + 191556 + ], + "children": [ + 191549 + ], + "area": 302383.67381400004, + "iscrowd": 0, + "segmentation": [], + "text": "RESULTS" + }, + { + "id": 191549, + "strid": "1817592b-730c-4118-8e10-a1e3749fb2c9", + "image_id": 207981, + "image_name": "9193.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 409.4, + 597.268, + 351.23799999999994, + 267.408 + ], + "priority": 12, + "parents": [ + 191545 + ], + "children": [], + "area": 244521.5192, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 191546, + "strid": "e5c8b81c-0085-485e-8651-3edb3c51f510", + "image_id": 207981, + "image_name": "9193.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 182.466, + 932.27, + 121.238, + 15.288999999999987 + ], + "priority": 13, + "parents": [ + 191556 + ], + "children": [ + 191550 + ], + "area": 170107.57782, + "iscrowd": 0, + "segmentation": [], + "text": "CONCLUSIONS" + }, + { + "id": 191550, + "strid": "371fb035-1638-4482-84b4-4dea3ccaba40", + "image_id": 207981, + "image_name": "9193.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 49.904, + 975.782, + 375.79, + 98.36099999999999 + ], + "priority": 14, + "parents": [ + 191546 + ], + "children": [], + "area": 48695.42492800001, + "iscrowd": 0, + "segmentation": [], + "text": "Surprisingly, our patients present a stable membrane\nfunction over time. Possible explanations could be the low\nperitonitis rate (0.14 infections per patientyears) and\ninfrequent use of hypertonic glucose _ dialysates.\nUltrafiltration failure -as expected-is correlated with higher\nbaseline D/P creatinine values." + }, + { + "id": 191557, + "strid": "987baf93-4d93-40ca-a7bf-df4b7124a477", + "image_id": 207981, + "image_name": "9193.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 549.582, + 956.365, + 114.50999999999999, + 14.335000000000036 + ], + "priority": 15, + "parents": [ + 191556 + ], + "children": [ + 191553 + ], + "area": 525600.98943, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 191553, + "strid": "4a444bfa-a2cf-4d38-8601-ec84af949a0b", + "image_id": 207981, + "image_name": "9193.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 487.341, + 999.253, + 234.30499999999995, + 106.67700000000002 + ], + "priority": 16, + "parents": [ + 191557 + ], + "children": [], + "area": 486976.95627300005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 184443, + "strid": "0463da35-50e5-421c-afa6-26f1e0b2708d", + "image_id": 207696, + "image_name": "8610.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 168.58, + 120.6, + 205.12999999999997, + 140.09 + ], + "priority": -1, + "parents": [], + "children": [ + 184413, + 184432, + 184417, + 184414, + 184416, + 184418, + 184412, + 184415 + ], + "area": 20330.748, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 184412, + "strid": "b090c076-a82e-4cb1-a743-d05522711b7e", + "image_id": 207696, + "image_name": "8610.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 472.505, + 134.7, + 3856.827, + 146.07099999999997 + ], + "priority": 1, + "parents": [ + 184443 + ], + "children": [], + "area": 63646.4235, + "iscrowd": 0, + "segmentation": [], + "text": "Epidemiological Modeling of HIV/TB Transmission Dynamics" + }, + { + "id": 184413, + "strid": "6e744f54-88e8-4e2f-ab9c-3edd6dd57b05", + "image_id": 207696, + "image_name": "8610.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1345.254, + 301.973, + 2109.316, + 203.834 + ], + "priority": 2, + "parents": [ + 184443 + ], + "children": [], + "area": 406230.386142, + "iscrowd": 0, + "segmentation": [], + "text": "'Narges Dorratoltaj, '*Jennifer Samuels, 'Kaja Abbas\n\n‘Population Health Sciences, “Human Nutrition, Foods, and Exercise" + }, + { + "id": 184414, + "strid": "ebd18300-aa83-4d70-ae95-48bc1a59549a", + "image_id": 207696, + "image_name": "8610.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 404.73, + 644.6, + 473.9649999999999, + 75.71100000000001 + ], + "priority": 3, + "parents": [ + 184443 + ], + "children": [ + 184422 + ], + "area": 260888.958, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 184422, + "strid": "5692410d-efcc-475f-be1f-1e5b926c55fe", + "image_id": 207696, + "image_name": "8610.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 112.701, + 799.098, + 1035.034, + 647.0149999999999 + ], + "priority": 4, + "parents": [ + 184414 + ], + "children": [], + "area": 90059.14369799999, + "iscrowd": 0, + "segmentation": [], + "text": "In 2011, people living with HIV were 34 million, people\nnewly infected with HIV were 2.5 million, and AIDS\ndeaths were 1.7 million [1]. In 2011, 8.7 million people\nfell ill with TB, with 1.1 million cases among people with\nHIV, and 1.4 million deaths, including 430,000 deaths\namong people living with HIV [1,2]. HIV and TB have a\nsynergistic interaction; each disease accelerates the\nepidemic progression of the other disease. Modeling\nHIV/TB co-infection and transmission dynamics assists\nto understand, analyze and improve prevention and\ncontrol programs to lower the epidemiological burden of\nboth HIV and TB." + }, + { + "id": 184432, + "strid": "560090ae-0924-42ff-85a4-590704048c03", + "image_id": 207696, + "image_name": "8610.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1594.033, + 645.239, + 453.577, + 77.01199999999994 + ], + "priority": 5, + "parents": [ + 184443 + ], + "children": [ + 184438, + 184435, + 184434, + 184433, + 184437, + 184436 + ], + "area": 1028532.258887, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 184433, + "strid": "08eb93c7-8962-43f7-88e3-44deae31737f", + "image_id": 207696, + "image_name": "8610.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1289.5, + 797.082, + 1023.922, + 207.788 + ], + "priority": 6, + "parents": [ + 184432 + ], + "children": [], + "area": 1027837.239, + "iscrowd": 0, + "segmentation": [], + "text": "Tuberculosis (TB) is caused by bacillus mycobacterium\ntuberculosis, affects the lungs, and is spread through\nairborne transmission. Globally, one-third of people are\ninfected with TB." + }, + { + "id": 184434, + "strid": "bebe89c5-31ed-49e7-aebd-d122c2d07395", + "image_id": 207696, + "image_name": "8610.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1290.067, + 1074.395, + 1050.799, + 378.509 + ], + "priority": 7, + "parents": [ + 184432 + ], + "children": [], + "area": 1386041.534465, + "iscrowd": 0, + "segmentation": [], + "text": "Latent tuberculosis infection\n\nLatent tuberculosis infection (LTBI) refers to the\ncondition among individuals, who are infected by TB, but\nare non-symptomatic and non-infectious. While 5% of\nthem carry a risk of developing active TB disease within\ntwo years, another 5% of them will develop active TB\ndisease within their lifetime [3]." + }, + { + "id": 184435, + "strid": "8e8d87c3-26e8-4349-b2b8-59ea5dc65e8c", + "image_id": 207696, + "image_name": "8610.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1288.793, + 1515.686, + 1053.57, + 376.8900000000001 + ], + "priority": 8, + "parents": [ + 184432 + ], + "children": [], + "area": 1953405.5069979997, + "iscrowd": 0, + "segmentation": [], + "text": "Tuberculosis disease\n\nPeople with active TB disease are infectious, exhibit\nsymptoms including bad cough and chest pains, and can\ndie if not treated well. TB can be treated by first line\ndrugs, lasting around 6 months. If the first line drugs fail\nto cure, they are infected by multidrug resistant\ntuberculosis (MDR-TB)." + }, + { + "id": 184437, + "strid": "23503bbd-d7fb-4397-aaf5-a37a0d561499", + "image_id": 207696, + "image_name": "8610.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1291.735, + 1955.261, + 1014.3329999999999, + 425.3000000000002 + ], + "priority": 9, + "parents": [ + 184432 + ], + "children": [], + "area": 2525679.067835, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 184436, + "strid": "9ae8866b-7987-4c56-8fc1-7f24576715ec", + "image_id": 207696, + "image_name": "8610.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1291.453, + 2451.519, + 1004.3759999999997, + 266.34299999999985 + ], + "priority": 10, + "parents": [ + 184432 + ], + "children": [], + "area": 3166021.5671069995, + "iscrowd": 0, + "segmentation": [], + "text": "Mathematical models are developed to analyze the\ntransmission dynamics of TB, including emerging drug\nresistance [4]. Figure 1 illustrates the transmission\ndynamics model of TB, based on the susceptible -\nlatent/exposed - infectious - susceptible (SEIS) model." + }, + { + "id": 184438, + "strid": "e05160f3-c68c-47d5-9f37-02e33b0712f9", + "image_id": 207696, + "image_name": "8610.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1276.808, + 2771.682, + 1091.234, + 693.0410000000002 + ], + "priority": 11, + "parents": [ + 184432 + ], + "children": [ + 184419 + ], + "area": 3538905.7510559997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 184419, + "strid": "35994b7d-e682-4a50-89c8-740c576d34e2", + "image_id": 207696, + "image_name": "8610.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1504.047, + 3478.609, + 631.2779999999998, + 43.45100000000002 + ], + "priority": 12, + "parents": [ + 184438 + ], + "children": [], + "area": 5231991.430623, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1: TB transmission dynamics" + }, + { + "id": 184415, + "strid": "22af18e8-0a70-4bc2-9561-6cae4c899b92", + "image_id": 207696, + "image_name": "8610.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2762.196, + 648.649, + 469.7669999999998, + 79.202 + ], + "priority": 13, + "parents": [ + 184443 + ], + "children": [ + 184430, + 184441, + 184426, + 184440, + 184423, + 184442, + 184428 + ], + "area": 1791695.6732039999, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 184423, + "strid": "86af30df-c53a-4e41-b6c1-833680f9bd0c", + "image_id": 207696, + "image_name": "8610.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2466.4, + 798.504, + 1038.328, + 323.46899999999994 + ], + "priority": 14, + "parents": [ + 184415 + ], + "children": [], + "area": 1969430.2656, + "iscrowd": 0, + "segmentation": [], + "text": "Human immunodeficiency virus infection / acquired\nimmunodeficiency syndrome (HIV/AIDS) prevention and\ntreatment can be improved by using models to\nunderstand and analyze the population health\n\nbenefits of HIV combination preventions - biomedical,\nsocio-behavioral, and structural [5,6, 7]." + }, + { + "id": 184428, + "strid": "79317abb-5f4f-4452-9782-6d397bfbb9f4", + "image_id": 207696, + "image_name": "8610.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2469.403, + 1185.422, + 1002.1860000000001, + 267.38200000000006 + ], + "priority": 15, + "parents": [ + 184415 + ], + "children": [], + "area": 2927284.6430659997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 184430, + "strid": "150c271b-01e5-4d83-902c-065b3128d5f7", + "image_id": 207696, + "image_name": "8610.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2469.118, + 1516.888, + 681.6399999999999, + 651.8469999999998 + ], + "priority": 16, + "parents": [ + 184415 + ], + "children": [], + "area": 3745375.4647839996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 184426, + "strid": "e7752c58-d465-4cbf-a8f4-3290f797e0ea", + "image_id": 207696, + "image_name": "8610.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2468.047, + 2230.801, + 1021.7689999999998, + 103.41600000000017 + ], + "priority": 17, + "parents": [ + 184415 + ], + "children": [], + "area": 5505721.715647, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2 illustrates the transmission dynamics model of\nHIV, based on the susceptible - infectious (SI) model." + }, + { + "id": 184440, + "strid": "870a2766-c491-4d20-a382-6495ac1ecb3e", + "image_id": 207696, + "image_name": "8610.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2857.498, + 2418.669, + 473.9340000000002, + 367.576 + ], + "priority": 18, + "parents": [ + 184415 + ], + "children": [], + "area": 6911341.830162, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 184441, + "strid": "aee3efe8-95c1-4006-a0f0-97c7b78c6564", + "image_id": 207696, + "image_name": "8610.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2620.427, + 2844.238, + 901.3620000000001, + 408.00099999999975 + ], + "priority": 19, + "parents": [ + 184415 + ], + "children": [ + 184420 + ], + "area": 7453118.049626, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 184420, + "strid": "d1eaf306-1538-4a07-9fd4-23986986a02d", + "image_id": 207696, + "image_name": "8610.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2621.064, + 3478.14, + 748.4070000000002, + 43.090999999999894 + ], + "priority": 20, + "parents": [ + 184441 + ], + "children": [], + "area": 9116427.540959999, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2: HIV/AIDS transmission dynamics" + }, + { + "id": 184442, + "strid": "eb6506ca-0dad-4ec7-86e0-9e71f7ebe2a9", + "image_id": 207696, + "image_name": "8610.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2468.23, + 3292.785, + 332.75199999999995, + 130.51900000000023 + ], + "priority": 21, + "parents": [ + 184415 + ], + "children": [], + "area": 8127350.72055, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 184416, + "strid": "69178e16-7e8b-4faf-9c9e-bc17964095f4", + "image_id": 207696, + "image_name": "8610.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3870.362, + 645.454, + 604.607, + 78.04099999999994 + ], + "priority": 22, + "parents": [ + 184443 + ], + "children": [ + 184425, + 184429, + 184424, + 184431 + ], + "area": 2498140.634348, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 184429, + "strid": "6ac740ff-b3d0-4de8-91d5-6b2ce9f5e66a", + "image_id": 207696, + "image_name": "8610.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3646.102, + 798.736, + 1039.005, + 212.59699999999998 + ], + "priority": 23, + "parents": [ + 184416 + ], + "children": [], + "area": 2912272.9270719998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 184424, + "strid": "b83fd494-74a2-43d0-b95d-565ddecd0ce7", + "image_id": 207696, + "image_name": "8610.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3642.769, + 1073.811, + 1051.4059999999995, + 539.0420000000001 + ], + "priority": 24, + "parents": [ + 184416 + ], + "children": [], + "area": 3911645.4226589995, + "iscrowd": 0, + "segmentation": [], + "text": "People living with HIV, dying of TB\n\nIn 2011, 430,000 people died of HIV-associated TB [1].\nPeople living with HIV and co-infected with LTBI are\nrelatively 20-30 times more susceptible to develop active\nTB compared to people with only LTBI [8]. For LTBI with\nHIV co-infection, the annual risk of progressing to active\nTB increases to 10%. More than one-fourth of deaths\namong people with HIV are due to TB, although there\nare effective treatments available to control both\ndiseases." + }, + { + "id": 184425, + "strid": "fd6084e1-f42f-4cb7-b305-b94aa3ba41cb", + "image_id": 207696, + "image_name": "8610.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3644.826, + 1681.549, + 1032.9800000000005, + 707.531 + ], + "priority": 25, + "parents": [ + 184416 + ], + "children": [], + "area": 6128953.515474, + "iscrowd": 0, + "segmentation": [], + "text": "HIV treatment as prevention\n\nHIV treatment has preventive effect, by reducing viral\nloads among HIV positive individuals and decreasing the\ntransmission risk to HIV negative individuals.\n\nModels of HIV/TB transmission dynamics enhance our\nunderstanding to improve the prevention and control\nprograms [9,10]. Figure 3 illustrates the modeling\nframework for understanding the HIV/TB co-infection\ndynamics, and the transmission dynamics of HIV and\nTB. The challenge is to optimize the combination of HIV\nand TB prevention and control programs to effectively\nlower the epidemiological burden of the dual epidemics." + }, + { + "id": 184431, + "strid": "f2cbac94-dddf-4bb7-9e47-3c69dd0d3e7d", + "image_id": 207696, + "image_name": "8610.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3618.864, + 2419.971, + 1097.1830000000004, + 595.3049999999998 + ], + "priority": 26, + "parents": [ + 184416 + ], + "children": [ + 184421 + ], + "area": 8757545.932944, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 184421, + "strid": "6fa12464-1329-4591-82f1-c54c2f052f59", + "image_id": 207696, + "image_name": "8610.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 3837.658, + 3059.795, + 687.9490000000001, + 47.94300000000021 + ], + "priority": 27, + "parents": [ + 184431 + ], + "children": [], + "area": 11742446.76011, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3: HIV/TB co-infection dynamics" + }, + { + "id": 184418, + "strid": "050a0022-1002-4e83-b184-996efeb63c40", + "image_id": 207696, + "image_name": "8610.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 151.061, + 3231.711, + 972.937, + 76.98700000000008 + ], + "priority": 28, + "parents": [ + 184443 + ], + "children": [ + 184439 + ], + "area": 488185.49537099997, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 184439, + "strid": "6e0761f0-8d8c-4f4a-a820-7891be337365", + "image_id": 207696, + "image_name": "8610.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 112.699, + 3366.489, + 1050.739, + 143.52599999999984 + ], + "priority": 29, + "parents": [ + 184418 + ], + "children": [], + "area": 379399.943811, + "iscrowd": 0, + "segmentation": [], + "text": "ND is supported (in part) by the Clinic on the Meaningful\nModeling of Epidemiological Data, Muizenberg, South Africa,\n2013." + }, + { + "id": 184417, + "strid": "f7db6871-cd5a-44df-9bca-29ba39222920", + "image_id": 207696, + "image_name": "8610.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 354.165, + 1617.021, + 575.973, + 78.00600000000009 + ], + "priority": 30, + "parents": [ + 184443 + ], + "children": [ + 184427 + ], + "area": 572692.242465, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 184427, + "strid": "64fa43f0-c880-4fcf-8d5d-471c3f3770c8", + "image_id": 207696, + "image_name": "8610.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 91.079, + 1753.338, + 1100.546, + 1310.706 + ], + "priority": 31, + "parents": [ + 184417 + ], + "children": [], + "area": 159692.271702, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 95691, + "strid": "11267d58-b69a-464e-86e4-c509ea3e05e3", + "image_id": 204198, + "image_name": "121628.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 318.33, + 318.18, + 395.90000000000003, + 229.87999999999994 + ], + "priority": -1, + "parents": [], + "children": [ + 95680, + 95673, + 95674, + 95682, + 95675, + 95684, + 95678, + 95677, + 95671, + 95688, + 95689, + 95683, + 95690, + 95676, + 95672, + 95685, + 95686, + 95687, + 95679 + ], + "area": 101286.23939999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 95671, + "strid": "1bcf032c-be2d-4ebf-b79f-dff55483527b", + "image_id": 204198, + "image_name": "121628.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 995.223, + 313.692, + 2713.839, + 248.42200000000003 + ], + "priority": 1, + "parents": [ + 95691 + ], + "children": [], + "area": 312193.493316, + "iscrowd": 0, + "segmentation": [], + "text": "Citizen Science on the Schoolyard:\nMeeting the Needs of Teachers, Students, and Scientists" + }, + { + "id": 95672, + "strid": "326903d8-cb46-4dc6-9c41-fa03128241f6", + "image_id": 204198, + "image_name": "121628.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 106.244, + 637.697, + 4488.094, + 116.78200000000004 + ], + "priority": 2, + "parents": [ + 95691 + ], + "children": [], + "area": 67751.480068, + "iscrowd": 0, + "segmentation": [], + "text": "Citizen science can motivate and inspire students. They connect to the natural world as they make observations, collect data, and view their findings within the broader scope of the project.\nNot just learning science, students are actually being scientists." + }, + { + "id": 95673, + "strid": "48a28685-6027-442d-aaad-d9024cf87edf", + "image_id": 204198, + "image_name": "121628.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 128.151, + 854.418, + 2094.645, + 168.05499999999995 + ], + "priority": 3, + "parents": [ + 95691 + ], + "children": [], + "area": 109494.521118, + "iscrowd": 0, + "segmentation": [], + "text": "Participating in citizen science creates opportunities for students to learn science concepts related to\nlife cycles, habitats, adaptation, phenology, and ecological interrelationships. Teachers desire\ntraining and lessons related to participation, science content, and inquiry learning." + }, + { + "id": 95677, + "strid": "9e3723be-af69-4f06-b24f-451232e38ff5", + "image_id": 204198, + "image_name": "121628.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 813.475, + 1104.521, + 719.87, + 51.1869999999999 + ], + "priority": 4, + "parents": [ + 95691 + ], + "children": [], + "area": 898500.220475, + "iscrowd": 0, + "segmentation": [], + "text": "Supporting Teachers Through..." + }, + { + "id": 95685, + "strid": "795b9d31-ba8b-429d-b982-736956adae11", + "image_id": 204198, + "image_name": "121628.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 150.946, + 1222.317, + 900.5199999999999, + 703.3910000000001 + ], + "priority": 5, + "parents": [ + 95691 + ], + "children": [ + 95681 + ], + "area": 184503.861882, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 95681, + "strid": "a833bb28-006c-4959-8a22-f606cc9de9ac", + "image_id": 204198, + "image_name": "121628.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 246.768, + 1954.535, + 716.191, + 135.56000000000017 + ], + "priority": 6, + "parents": [ + 95685 + ], + "children": [], + "area": 482316.69288000005, + "iscrowd": 0, + "segmentation": [], + "text": "Teachers at our summer retreat learn about\nand practice citizen-science protocols\nand explore data" + }, + { + "id": 95684, + "strid": "f04e562b-3b21-41a8-9161-109ff5610859", + "image_id": 204198, + "image_name": "121628.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1193.577, + 1222.078, + 807.8689999999999, + 782.78 + ], + "priority": 7, + "parents": [ + 95691 + ], + "children": [], + "area": 1458644.193006, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 95678, + "strid": "f0e048c0-28e1-4554-b3c6-8d8578a51195", + "image_id": 204198, + "image_name": "121628.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 591.198, + 2341.561, + 1165.2020000000002, + 46.021000000000186 + ], + "priority": 8, + "parents": [ + 95691 + ], + "children": [], + "area": 1384326.180078, + "iscrowd": 0, + "segmentation": [], + "text": "Curricula, Books, Blog Posts, and Downloadable Lessons" + }, + { + "id": 95686, + "strid": "e27c3cab-6d56-4f70-ac42-fe0a344c0e7b", + "image_id": 204198, + "image_name": "121628.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 85.418, + 2515.872, + 2218.37, + 823.366 + ], + "priority": 9, + "parents": [ + 95691 + ], + "children": [], + "area": 214900.754496, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 95674, + "strid": "4b8cca5b-bd70-494e-9faf-676eff67fe88", + "image_id": 204198, + "image_name": "121628.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2644.346, + 857.732, + 1985.1380000000004, + 227.36400000000003 + ], + "priority": 10, + "parents": [ + 95691 + ], + "children": [], + "area": 2268140.183272, + "iscrowd": 0, + "segmentation": [], + "text": "Citizen-science activities fulfill the NGSS mandate to couple science practice with content, and\ngive students a real-world context in which to apply what they learn. 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"priority": 13, + "parents": [ + 29118 + ], + "children": [], + "area": 3801034.532489, + "iscrowd": 0, + "segmentation": [], + "text": "SDS-PAGE" + }, + { + "id": 29123, + "strid": "827bdb6f-24dd-4f59-a9b7-b0039499f63e", + "image_id": 201649, + "image_name": "117457.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1775.616, + 1485.843, + 487.1819999999998, + 385.44100000000003 + ], + "priority": 14, + "parents": [ + 29118 + ], + "children": [], + "area": 2638286.604288, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 29129, + "strid": "9fe027bf-ffa2-414a-be38-00dea754b96d", + "image_id": 201649, + "image_name": "117457.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1603.439, + 1877.154, + 664.1099999999999, + 98.58600000000001 + ], + "priority": 15, + "parents": [ + 29118 + ], + "children": [], + "area": 3009901.932606, + "iscrowd": 0, + "segmentation": [], + "text": "Bands were excised and the proteins\nidentified using mass spectrometry" + }, + { + "id": 29131, + "strid": "741f1a2b-f031-4c36-ace2-8e0a15acb0c5", + "image_id": 201649, + "image_name": "117457.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1543.171, + 2069.069, + 224.96299999999997, + 61.353999999999814 + ], + "priority": 16, + "parents": [ + 29138 + ], + "children": [ + 29132, + 29134, + 29133 + ], + "area": 3192927.277799, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 29132, + "strid": "dcd35a8b-1ec6-4d16-bbbb-48a0cee2a085", + "image_id": 201649, + "image_name": "117457.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 20.464, + 2145.011, + 2086.175, + 1100.3740000000003 + ], + "priority": 17, + "parents": [ + 29131 + ], + "children": [], + "area": 43895.505103999996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 29133, + "strid": "71b6c64f-1a5c-4706-8634-9790a838e224", + "image_id": 201649, + "image_name": "117457.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2120.96, + 2185.589, + 1169.594, + 1050.248 + ], + "priority": 18, + "parents": [ + 29131 + ], + "children": [], + "area": 4635546.84544, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 29134, + "strid": "d752bb4b-965a-4e4b-b878-416480942110", + "image_id": 201649, + "image_name": "117457.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 24.994, + 3254.932, + 3248.852, + 440.31500000000005 + ], + "priority": 19, + "parents": [ + 29131 + ], + "children": [], + "area": 81353.770408, + "iscrowd": 0, + "segmentation": [], + "text": "(A) SDS-PAGE images of the time course of protein release from the articular cartilage explant model. M = molecular weight markers, C = control (no\ntreatment), IL = IL-1B (10 ng/ml), TIL = TNF-a (10 ng/mi) + IL-1B, R = Rimadyl® (100 ug/ml), RIL = Rimadyl® + IL-1B, RTIL = Rimadyl® + TNF-a + IL-1B.\nNumber of days that explants have been incubated since the start of time course. 0 Days corresponds to the 24 hour equilibration phase culture fluid.\n(B) SDS-PAGE of proteins from the time course at Day 6 displaying identities of selected proteins determined by tandem MS.\n\nPro-inflammatory cytokines treatment (IL-18 and TNF-a) stimulated alterations in the protein release profile (compared to control).\n\nMMP-3 release was stimulated by IL-1B and TNF-a, but after 12 days Rimadyl® treatment down-regulated MMP-3 levels (red box).\n\nBovine Serum Albumin (BSA) is present in IL-1B and TNF-a treated samples because it is used as a carrier protein for these cytokines." + }, + { + "id": 29135, + "strid": "a3c73225-4a3c-43e0-998d-ea37bc06abe9", + "image_id": 201649, + "image_name": "117457.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1460.751, + 3759.193, + 393.85799999999995, + 70.07299999999987 + ], + "priority": 20, + "parents": [ + 29138 + ], + "children": [ + 29136 + ], + "area": 5491244.933943001, + "iscrowd": 0, + "segmentation": [], + "text": "Conciusions" + }, + { + "id": 29136, + "strid": "4cdffe7d-cf8e-45ff-83f4-5cee32e7c6d6", + "image_id": 201649, + "image_name": "117457.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 26.959, + 3853.199, + 3207.364, + 546.5459999999998 + ], + "priority": 21, + "parents": [ + 29135 + ], + "children": [], + "area": 103878.391841, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 29137, + "strid": "85ddfd36-6f84-4c18-91a4-37422622383f", + "image_id": 201649, + "image_name": "117457.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1092.812, + 4426.867, + 1201.991, + 214.27400000000034 + ], + "priority": 22, + "parents": [ + 29138 + ], + "children": [], + "area": 4837733.380004, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements\n\nThis work received financial support, from the Biotechnology and\nBiological Sciences Research Councit(BBSRC) (Grant Reference No.\nBB/G018030/1) and the WALTHAM Centre for Pet Nutrition, UK." + }, + { + "id": 120482, + "strid": "f6ed9c0d-bca9-4d45-aadf-534cfcc72c61", + "image_id": 205192, + "image_name": "14423.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 25.25, + 28.1, + 73.75, + 241.37000000000003 + ], + "priority": -1, + "parents": [], + "children": [ + 120481, + 120476, + 120475, + 120470, + 120469, + 120478 + ], + "area": 709.5250000000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 120481, + "strid": "e9126e53-e118-41b9-89e1-cefced7098a0", + "image_id": 205192, + "image_name": "14423.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 141.81, + 7.79, + 1166.461, + 261.967 + ], + "priority": 1, + "parents": [ + 120482 + ], + "children": [], + "area": 1104.6999, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 120469, + "strid": "92089b16-2e12-40d3-8f86-bd42f265618e", + "image_id": 205192, + "image_name": "14423.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 24.535, + 331.321, + 1410.984, + 39.41199999999998 + ], + "priority": 2, + "parents": [ + 120482 + ], + "children": [], + "area": 8128.960735000001, + "iscrowd": 0, + "segmentation": [], + "text": "Antonia Lock, Midori A. Harris, Kim Rutherford, Jiro Bahiler, Stephen G. 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Fission yeast was described by\n\nPaul Lindner in 1893, and Urs Leopold isolated the standard\nlab strains in the 1940s." + }, + { + "id": 120473, + "strid": "75433e29-d8ad-490c-bd4b-e5fd81e3a462", + "image_id": 205192, + "image_name": "14423.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 833.594, + 1746.142, + 955.1410000000001, + 117.1210000000001 + ], + "priority": 7, + "parents": [ + 120470 + ], + "children": [], + "area": 1455573.494348, + "iscrowd": 0, + "segmentation": [], + "text": "“The taste is somewhat like soured wort of the smallest description, but\nstrangers, who at first dislike it exceedingly, are soon reconciled to it by the\npleasurable sensations to which it gives rise...”" + }, + { + "id": 120475, + "strid": "60980ee7-d83e-42b0-80ed-5586bb8ba768", + "image_id": 205192, + "image_name": "14423.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2086.451, + 502.391, + 716.433, + 58.31400000000002 + ], + "priority": 8, + "parents": 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3243.474, + 2290.0610000000006 + ], + "priority": 13, + "parents": [ + 120478 + ], + "children": [], + "area": 36661.247318, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 49064, + "strid": "fd1a0912-f7c8-4e91-a85a-286a2d110ab3", + "image_id": 202422, + "image_name": "118676.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 42.55, + 72.64, + 273.5, + 192.19 + ], + "priority": -1, + "parents": [], + "children": [ + 49057, + 49055, + 49062, + 49054, + 49059, + 49056, + 49060, + 49061, + 49063, + 49058 + ], + "area": 3090.832, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 49054, + "strid": "3d5bfd80-1979-4fe7-b839-9c483ba8d008", + "image_id": 202422, + "image_name": "118676.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 459.051, + 673.601, + 2366.239, + 183.55000000000007 + ], + "priority": 1, + "parents": [ + 49064 + ], + "children": [], + "area": 309217.212651, + "iscrowd": 0, + "segmentation": [], + "text": "The perks of being endolithic" + }, + { + "id": 49057, + "strid": "9ba07132-5859-4ef8-9cb7-0a2b0214d58c", + "image_id": 202422, + "image_name": "118676.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 440.196, + 131.134, + 2407.38, + 195.15 + ], + "priority": 2, + "parents": [ + 49064 + ], + "children": [], + "area": 57724.662264, + "iscrowd": 0, + "segmentation": [], + "text": "Christine Schonberg, Australian Institute of Marine Science\ncand Max Wisshak, Senckenberg am Meer, 2013" + }, + { + "id": 49055, + "strid": "44927a18-44b3-4d1e-b551-9d3885bc57ca", + "image_id": 202422, + "image_name": "118676.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 250.205, + 884.789, + 2808.285, + 662.3779999999999 + ], + "priority": 3, + "parents": [ + 49064 + ], + "children": [], + "area": 221378.63174500002, + "iscrowd": 0, + "segmentation": [], + "text": "Why do-bioeroding sponges live inside of hard substrates?\n\nIt has been assumed that they gain nutrition through bioerosion (Ward & Risk 1977),\nbut they are efficient filter feeders, just like free-living sponges (Schonberg & Pile,\nunpubl. data). On the whole it is more likely that the endolithiciJife style has a\nsheltering function, e.g. against desiccation (e.g. Schonberg 2001).\n\nIn June 2011 two sponges were sampled from the’shallow reef flat\nof Orpheus Island on the central Great Barrier Reef:" + }, + { + "id": 49056, + "strid": "6e906b9c-7132-4779-8a05-ec734b966df5", + "image_id": 202422, + "image_name": "118676.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 149.477, + 1635.579, + 3012.841, + 77.34899999999993 + ], + "priority": 4, + "parents": [ + 49064 + ], + "children": [], + "area": 244481.442183, + "iscrowd": 0, + "segmentation": [], + "text": "Siphonodictyon mucosum Bergquist, 1965 and Cliothosa aurivilli (Lindgren, 1898)" + }, + { + "id": 49060, + "strid": "00789fc8-f4ce-4eb9-86a8-1ae5a823419d", + "image_id": 202422, + "image_name": "118676.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 211.75, + 1764.112, + 898.7660000000001, + 1948.716 + ], + "priority": 5, + "parents": [ + 49064 + ], + "children": [], + "area": 373550.716, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 49058, + "strid": "aecddc07-1cdf-4b96-9c5b-7a4d05570f1f", + "image_id": 202422, + "image_name": "118676.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1168.755, + 1777.363, + 982.7159999999999, + 1987.046 + ], + "priority": 6, + "parents": [ + 49064 + ], + "children": [], + "area": 2077301.8930650002, + "iscrowd": 0, + "segmentation": [], + "text": "The post-fracture healing process\nwas observed inv ay flowthrough\ntank. Even though» both sponges\nproduce large ‘erosion chambers\nand their endolithic tissue is soft\nand vulnerable, they initially healed\nvery quickly, showing scarring and\nrecovery after only 3-4 days.\nHowever, endolithic tissue of S,\nmucosum exposed to _ . direct\nsunlight became putrid and rotted\n(R), partly leaving empty chambers\n(E), while shaded tissue healed (H),\ntoughened and turned brown-black\nlike the external fistules, thereby\nadapting to the higher light levels\nthat affects exposed parts.\nLikewise, endolithic tissue of C.\naurivilli healed by contracting,\ntoughening and flattening, but after\nabout two weeks, some C,. aurivillii\nnevertheless began to rot and had\npatches of orange sediment\nunderneath them. Their undersides\nwere teeming with small organisms\nthat were identified as copepods\nwhich had orange \\— stomach\ncontents of the same «colour as the\nsponge and produced rust-coloured\nfaeces." + }, + { + "id": 49061, + "strid": "0a382425-1e7e-4d23-89ce-8b3235dc3c5d", + "image_id": 202422, + "image_name": "118676.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2199.057, + 1764.14, + 905.096, + 1952.1560000000002 + ], + "priority": 7, + "parents": [ + 49064 + ], + "children": [], + "area": 3879444.41598, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 49059, + "strid": "fe6e7a47-6543-4c56-a3f5-fc6f4482f756", + "image_id": 202422, + "image_name": "118676.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 92.646, + 3910.11, + 3119.489, + 252.89299999999957 + ], + "priority": 8, + "parents": [ + 49064 + ], + "children": [], + "area": 362256.05106, + "iscrowd": 0, + "segmentation": [], + "text": "Hence, being endolithic has multiple sheltering functions beyond the obvious escape\nfrom grazers and predators, very likely including shading and shielding from parasites\nand disease, and savings on maintenance costs." + }, + { + "id": 49062, + "strid": "512849c8-b261-4ce3-98e0-6895f75b54ad", + "image_id": 202422, + "image_name": "118676.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 293.435, + 4196.08, + 2740.05, + 161.1959999999999 + ], + "priority": 9, + "parents": [ + 49064 + ], + "children": [], + "area": 1231276.7348, + "iscrowd": 0, + "segmentation": [], + "text": "Magee\nSchoénberg CHL (2001) Small-scale distribution of Australian bioeroding sponges in shallow water. Ophelia 55:39-54\nWard P, Risk MJ (1977) Boring patter of the sponge C/iona vermiferain the\\cofal Montastrea annularis. J Paleontol 51:520-526" + }, + { + "id": 49063, + "strid": "45884e9c-707c-47b9-8006-899e35b16a5e", + "image_id": 202422, + "image_name": "118676.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 557.761, + 4411.179, + 2175.244, + 109.04299999999967 + ], + "priority": 10, + "parents": [ + 49064 + ], + "children": [], + "area": 2460383.610219, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements Fieldwork was part of DFG project\nFr 1134/19 and)was co-funded by AIMS. OIRS staff professionally assisted|in their usual cheerful way." + }, + { + "id": 117484, + "strid": "7073f114-5b88-4517-9548-e1205de854cf", + "image_id": 205074, + "image_name": "14053.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 253.63, + 65.56, + 290.19000000000005, + 135.09 + ], + "priority": -1, + "parents": [], + "children": [ + 117468, + 117482, + 117467, + 117481, + 117471, + 117466, + 117473, + 117483 + ], + "area": 16627.9828, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 117482, + "strid": "cdac9310-8f0b-4a25-b644-e8ec6acf8c29", + "image_id": 205074, + "image_name": "14053.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 713.495, + 116.836, + 3380.19, + 111.87399999999998 + ], + "priority": 1, + "parents": [ + 117484 + ], + "children": [], + "area": 83361.90182, + "iscrowd": 0, + "segmentation": [], + "text": "A Reproducible and Reusable Deep Learning Pipeline on the NCI Cloud Resources" + }, + { + "id": 117483, + "strid": "cfcb0673-77d3-467e-bb8b-c68b1bd62133", + "image_id": 205074, + "image_name": "14053.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1278.192, + 242.028, + 2285.424, + 138.511 + ], + "priority": 2, + "parents": [ + 117484 + ], + "children": [], + "area": 309358.253376, + "iscrowd": 0, + "segmentation": [], + "text": "Madeline Kim’ and Hsinyi (Steve) Tsang~\n‘Center for Biomedical Informatics and Information Technology, National Cancer Institute, Rockville, MD 20850" + }, + { + "id": 117467, + "strid": "2e4e663b-ff1a-4182-a113-3860ac246249", + "image_id": 205074, + "image_name": "14053.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 159.051, + 469.108, + 300.155, + 68.07599999999996 + ], + "priority": 3, + "parents": [ + 117484 + ], + "children": [ + 117461 + ], + "area": 74612.09650799999, + "iscrowd": 0, + "segmentation": [], + "text": "OVERVIEW" + }, + { + "id": 117461, + "strid": "94bdb1c4-cd1b-4779-99af-d5b86f343717", + "image_id": 205074, + "image_name": "14053.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 125.013, + 580.505, + 1411.037, + 1838.0609999999997 + ], + "priority": 4, + "parents": [ + 117467 + ], + "children": [], + "area": 72570.671565, + "iscrowd": 0, + "segmentation": [], + "text": "High throughput technology has dramatically decreased the cost of\ngenetic sequencing over the past two decades, opening the door to new\navenues of cancer research.° Among the many tools developed to\nanalyze an ever-growing collection of sequencing data, machine\nlearning (ML) holds potential in predicting significant genetic variants\nthat can in turn be investigated in the lab. With the abundance of\ninformation and gamut of tools available today, it becomes ever more\nimportant that analyses are reproducible and consistent. An ideal ML\nanalysis workflow should observe all of the F.A.I.R. guidelines, i.e.\nFindability, Accessibility, Interoperability, and Reusability.2 The NCI\nCloud Resources, formerly the Cancer Genomics Cloud Pilots, offer an\nideal environment for performing computationally intensive analyses\nand sharing tools and data.”*°\n\nThe objective of this project was to create a user-friendly, reusable, and\nscalable machine learning pipeline to predict significant variants in\ncancer sequences. We selected DeepVariant, a machine learning\nprogram developed by Google and built on TensorFlow image\nclassification models trained on reads aligned to reference genomes,?\nand utilized Docker containerization technology to facilitate access and\nreusability on two of the NCI Cloud Resources: the Seven Bridges Cancer\nGenomics Cloud and the Broad Institute’s Firecloud. Containerizing\nDeepVariant on the cloud allows the user to bypass the cumbersome\nprocess of installing dependencies. Finally, the output can be visualized\nwith tools such as AVIA, an sequence annotation and visualization\nprogram.°\n\nWe tested our workflow with paired normal and tumor sequences from\n1 case of Infiltrating duct carcinoma (Case #1) and 1 case of B-cell\nfollicular lymphoma (Case #7) from the Texas BioBank.?" + }, + { + "id": 117466, + "strid": "f6dae7d2-b35e-49d7-bdac-337e98c2ffc4", + "image_id": 205074, + "image_name": "14053.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1727.901, + 469.108, + 1129.448, + 64.98200000000003 + ], + "priority": 5, + "parents": [ + 117484 + ], + "children": [ + 117465, + 117463 + ], + "area": 810572.182308, + "iscrowd": 0, + "segmentation": [], + "text": "SEVEN BRIDGES CANCER GENOMICS CLOUD" + }, + { + "id": 117465, + "strid": "3271e33a-2b3d-44f6-bdff-88da2cd9b31d", + "image_id": 205074, + "image_name": "14053.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1690.768, + 571.222, + 1414.1310000000003, + 479.62900000000013 + ], + "priority": 6, + "parents": [ + 117466 + ], + "children": [ + 117464 + ], + "area": 965803.878496, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 117464, + "strid": "2f9405ff-7c67-4f39-8f40-7e6b1036427c", + "image_id": 205074, + "image_name": "14053.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1693.863, + 1128.21, + 1411.037, + 198.03999999999996 + ], + "priority": 7, + "parents": [ + 117465 + ], + "children": [], + "area": 1911033.1752300002, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. DeepVariant Pipeline: reads aligned to a genome are\npassed in with the original genome, then scanned for potential\nvariants, analyzed with a trained model, and output as a VCF file." + }, + { + "id": 117463, + "strid": "c3bdf5e5-b331-4aaf-8f79-60eda1c7e728", + "image_id": 205074, + "image_name": "14053.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1684.58, + 1437.648, + 1414.1310000000003, + 677.6690000000001 + ], + "priority": 8, + "parents": [ + 117466 + ], + "children": [ + 117462 + ], + "area": 2421833.0678399997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 117462, + "strid": "3bf830b7-b20a-4fc4-9040-1fac75e8d42f", + "image_id": 205074, + "image_name": "14053.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1693.863, + 2205.054, + 1364.6210000000003, + 194.9459999999999 + ], + "priority": 9, + "parents": [ + 117463 + ], + "children": [], + "area": 3735059.3836020003, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2. Workflow diagram of DeepVariant implementation on\nthe Seven Bridges Cancer Genomics Cloud platform.?\nhttp://www.cancergenomicscloud.org/" + }, + { + "id": 117471, + "strid": "b21039a3-8405-4183-986f-20907a1c6cee", + "image_id": 205074, + "image_name": "14053.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1732.322, + 2463.214, + 344.8019999999999, + 66.30799999999999 + ], + "priority": 10, + "parents": [ + 117484 + ], + "children": [ + 117470 + ], + "area": 4267079.802908, + "iscrowd": 0, + "segmentation": [], + "text": "CONCLUSION" + }, + { + "id": 117470, + "strid": "4dcf9608-5a53-4472-9d0a-1f12cf5364d4", + "image_id": 205074, + "image_name": "14053.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1690.326, + 2584.779, + 1405.732, + 906.2109999999998 + ], + "priority": 11, + "parents": [ + 117471 + ], + "children": [], + "area": 4369119.147954, + "iscrowd": 0, + "segmentation": [], + "text": "The NCI Cloud Resources provide secure access to petabyte-scale\ndata and high performance, elastic computing environment for the\ncancer research community. On both the Cancer Genomics Cloud\nand the Firecloud, users can upload own data or access data from\nmultiple sources, including The Cancer Genome Atlas (TCGA),\ndirectly on the platform, eliminating the need to download files to\ntheir machines.\n\nThis implementation of DeepVariant demonstrates the potential of\nmachine learning in predicting disease-associated variants backed\nby power of cloud computing. In preliminary tests of the workflow,\nDeepVariant returned more disease-associated variants in tumor\nsamples than in normal samples, as well as more potential variants\noverall. Most of these mutations, however, are not noted in the\ndbSNP, highlighting the need for verification of and further research\ninto the significance of ML predictions." + }, + { + "id": 117481, + "strid": "4c9ba98f-2646-4fd1-8cfe-4c9f9a6657f1", + "image_id": 205074, + "image_name": "14053.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3306.306, + 472.914, + 783.1169999999997, + 62.649 + ], + "priority": 12, + "parents": [ + 117484 + ], + "children": [ + 117474, + 117480, + 117475, + 117476 + ], + "area": 1563598.3956839999, + "iscrowd": 0, + "segmentation": [], + "text": "BROAD INSTITUTE FIRECLOUD" + }, + { + "id": 117480, + "strid": "22157829-f6d9-4922-afec-37481bb60224", + "image_id": 205074, + "image_name": "14053.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3263.794, + 579.866, + 1388.1310000000003, + 179.89300000000003 + ], + "priority": 13, + "parents": [ + 117481 + ], + "children": [], + "area": 1892563.1716039998, + "iscrowd": 0, + "segmentation": [], + "text": "The DeepVariant pipeline on Firecloud is accessible via Dockstore.\nThe user will need a FireCloud account and a billing project on the\nFireCloud platform to copy and run the analysis." + }, + { + "id": 117476, + "strid": "7003d8e6-f669-41da-9cf2-999fbdd9abe3", + "image_id": 205074, + "image_name": "14053.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3272.225, + 766.149, + 856.346, + 444.57799999999986 + ], + "priority": 14, + "parents": [ + 117481 + ], + "children": [ + 117477 + ], + "area": 2507011.911525, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 117477, + "strid": "e608e473-d1ec-454f-b5bc-2d299c402eea", + "image_id": 205074, + "image_name": "14053.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 4162.777, + 779.198, + 492.0479999999998, + 371.0100000000001 + ], + "priority": 15, + "parents": [ + 117476 + ], + "children": [], + "area": 3243627.512846, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3. Following the\nlink provided at the\nbottom of the section,\nselect “FireCloud” to\nbe directed to the\nFireCloud platform." + }, + { + "id": 117475, + "strid": "3d2c5e49-de3d-47ea-b78c-2e75c84aa879", + "image_id": 205074, + "image_name": "14053.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3265.512, + 1218.621, + 865.6889999999999, + 392.05999999999995 + ], + "priority": 16, + "parents": [ + 117481 + ], + "children": [ + 117478 + ], + "area": 3979421.4989520004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 117478, + "strid": "12f4925e-9612-4d89-b998-19a3bcdebcd6", + "image_id": 205074, + "image_name": "14053.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 4160.146, + 1231.777, + 497.3109999999997, + 368.37799999999993 + ], + "priority": 17, + "parents": [ + 117475 + ], + "children": [], + "area": 5124372.159442, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 4. The user will\nthen need to select an\nexisting workspace or\ncreate a new one to\nwhich the workflow\nwill be copied." + }, + { + "id": 117474, + "strid": "533ede18-b4d5-4f77-b361-10b6e2f9026b", + "image_id": 205074, + "image_name": "14053.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3270.775, + 1629.1, + 868.3210000000004, + 663.0810000000001 + ], + "priority": 18, + "parents": [ + 117481 + ], + "children": [ + 117479 + ], + "area": 5328419.5525, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 117479, + "strid": "e3f42db4-755e-4a4f-932c-d76a7c9e2d91", + "image_id": 205074, + "image_name": "14053.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 4157.514, + 1639.625, + 505.2049999999999, + 610.4560000000001 + ], + "priority": 19, + "parents": [ + 117474 + ], + "children": [], + "area": 6816763.8922500005, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 5. To complete\npreparations to launch\nthe analysis, the user\nwill need to import\nmetadata and define\nworkspace _ attributes,\nas well as edit the\nmethod configuration\nand specify values for\ninputs and outputs." + }, + { + "id": 117473, + "strid": "6b949e11-2246-410f-bd1c-5465d52655d8", + "image_id": 205074, + "image_name": "14053.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3314.05, + 2458.793, + 597.598, + 74.21199999999999 + ], + "priority": 20, + "parents": [ + 117484 + ], + "children": [ + 117472 + ], + "area": 8148562.94165, + "iscrowd": 0, + "segmentation": [], + "text": "ACKNOWLEDGEMENTS" + }, + { + "id": 117472, + "strid": "7a43e78c-c44c-4db4-ae48-1dcde9de2e99", + "image_id": 205074, + "image_name": "14053.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3272.88, + 2584.779, + 1394.6809999999996, + 486.25999999999976 + ], + "priority": 21, + "parents": [ + 117473 + ], + "children": [], + "area": 8459671.493520001, + "iscrowd": 0, + "segmentation": [], + "text": "This project has been funded in whole or in part with Federal\nfunds from the National Cancer Institute, National Institutes of\nHealth, Task Order No. 17X053 under Contract No.\nHHSN261200800001E. The content of this publication does not\nnecessarily reflect the views or policies of the Department of\nHealth and Human Services, nor does mention of trade names,\ncommercial products, or organizations imply endorsement by the\nU.S. Government." + }, + { + "id": 117468, + "strid": "c6193b5e-2e15-44bc-b762-97176054e5c4", + "image_id": 205074, + "image_name": "14053.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 149.768, + 2464.982, + 334.193, + 71.17099999999982 + ], + "priority": 22, + "parents": [ + 117484 + ], + "children": [ + 117469 + ], + "area": 369175.424176, + "iscrowd": 0, + "segmentation": [], + "text": "REFERENCES" + }, + { + "id": 117469, + "strid": "9e51bf09-12e1-41f9-91ce-2baef778d7ae", + "image_id": 205074, + "image_name": "14053.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 123.245, + 2580.358, + 1396.891, + 930.5239999999999 + ], + "priority": 23, + "parents": [ + 117468 + ], + "children": [], + "area": 318016.22171, + 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NC, negative control." + }, + { + "id": 67813, + "strid": "32e354e1-c55b-4d65-8922-7b5395763b7a", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 811.853, + 2099.948, + 494.745, + 453.547 + ], + "priority": 20, + "parents": [ + 67806 + ], + "children": [ + 67811 + ], + "area": 1704849.0836439999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 67811, + "strid": "4f778c43-9aaf-44f8-9f8c-b771fb732c3a", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 751.365, + 1914.499, + 604.577, + 68.76999999999998 + ], + "priority": 21, + "parents": [ + 67813 + ], + "children": [], + "area": 1438487.541135, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 2 Testosterone 6B-hydroxylation activity\nin the liver microsomes" + }, + { + "id": 67808, + "strid": "2e30cea1-2fd9-486e-85fb-e36f31df5090", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 740.39, + 2587.59, + 624.667, + 58.38200000000006 + ], + "priority": 22, + "parents": [ + 67806 + ], + "children": [], + "area": 1915825.7601, + "iscrowd": 0, + "segmentation": [], + "text": "Testosterone(30 LM),was incubated with liver microsomes of WT and KO mice. Data are\nshown aSithe Mean + S. E. M. (n = 5-6) of three independent determinations, each\nperformed ifiduplicate. ***P < 0.001 versus WT mice." + }, + { + "id": 67805, + "strid": "93215dd5-7ade-45a2-a96b-0ba554d222db", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2043.58, + 1782.834, + 604.1109999999999, + 101.394 + ], + "priority": 23, + "parents": [ + 67806 + ], + "children": [], + "area": 3643363.90572, + "iscrowd": 0, + "segmentation": [], + "text": "Effects of Cyp3a deficiency on\ntestosterone levéls" + }, + { + "id": 67814, + "strid": "d6926d8b-6222-4d73-a2d8-ff804c69048e", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1411.722, + 1972.648, + 640.3929999999998, + 579.3680000000002 + ], + "priority": 24, + "parents": [ + 67806 + ], + "children": [ + 67812 + ], + "area": 2784830.579856, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 67812, + "strid": "3982b5b0-d6e0-492e-8caa-32cceec4bae0", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1879.08, + 1915.303, + 929.0720000000001, + 32.85799999999995 + ], + "priority": 25, + "parents": [ + 67814 + ], + "children": [], + "area": 3599007.56124, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 3 Total hepatic, total plasma and fre@yplasma testosterone levels" + }, + { + "id": 67815, + "strid": "2694037c-8055-4bef-86f2-f75a6a20d99a", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2082.782, + 1974.991, + 1192.4470000000001, + 576.1480000000001 + ], + "priority": 26, + "parents": [ + 67806 + ], + "children": [], + "area": 4113475.7049620003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 67809, + "strid": "fc8f5ed2-6d80-4f5c-b895-ed82b3a26a77", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1422.25, + 2587.727, + 1840.808, + 37.61499999999978 + ], + "priority": 27, + "parents": [ + 67806 + ], + "children": [], + "area": 3680394.7257499998, + "iscrowd": 0, + "segmentation": [], + "text": "The levels of total hepatic testosterone in WTand KO mice were determined by HPLC using pooled liver tissue from six mice. The levels of total and free plasma testosterone in WT and KOymice Were determined by ELISA using pooled plasma from six mice with or without\nalkanine extraction, respectively. Data are shownassmean + S. D. of triplicate determination. *P < 0.05, **P < 0.01, ***P < 0.001 versus WT mice." + }, + { + "id": 67791, + "strid": "ed918a16-5804-4c47-95c6-afa9934670f5", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 988.819, + 2702.61, + 1333.0139999999997, + 50.373999999999796 + ], + "priority": 28, + "parents": [ + 67806 + ], + "children": [], + "area": 2672392.11759, + "iscrowd": 0, + "segmentation": [], + "text": "Effects of Cyp3a deficiency on androgen response in the prostates" + }, + { + "id": 67803, + "strid": "6e57b6f3-d975-4275-9823-54ca22f80a75", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 35.925, + 2984.653, + 638.902, + 256.4830000000002 + ], + "priority": 29, + "parents": [ + 67806 + ], + "children": [ + 67796 + ], + "area": 107223.65902499999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 67796, + "strid": "d789015c-1801-4867-a58d-77188fcc3f7d", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 145.348, + 2794.025, + 440.599, + 34.63000000000011 + ], + "priority": 30, + "parents": [ + 67803 + ], + "children": [], + "area": 406105.94570000004, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1 Body and tissue weights" + }, + { + "id": 67792, + "strid": "845c7df8-2599-44d9-a42b-d46fd5e21ac6", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 37.026, + 3381.821, + 610.583, + 38.45499999999993 + ], + "priority": 31, + "parents": [ + 67806 + ], + "children": [], + "area": 125215.304346, + "iscrowd": 0, + "segmentation": [], + "text": "Data fomweight of body, prostate and seminal vesicle represent the mean = S. E. M. of six\n\nmicéin each group." + }, + { + "id": 67800, + "strid": "7652abe4-74a2-4e2b-970d-d04e65835c04", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 765.505, + 2940.951, + 437.4699999999999, + 305.5819999999999 + ], + "priority": 32, + "parents": [ + 67806 + ], + "children": [ + 67797 + ], + "area": 2251312.695255, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 67797, + "strid": "384e6312-05c4-4a1d-ab36-83bdf7939b60", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 762.165, + 2794.582, + 428.6089999999999, + 33.70899999999983 + ], + "priority": 33, + "parents": [ + 67800 + ], + "children": [], + "area": 2129932.5900299996, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 4 Expression levels of PSCA" + }, + { + "id": 67793, + "strid": "08a11741-6990-4be0-8067-80d832f366e9", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 742.11, + 3382.101, + 465.9910000000001, + 57.31899999999996 + ], + "priority": 34, + "parents": [ + 67806 + ], + "children": [], + "area": 2509890.97311, + "iscrowd": 0, + "segmentation": [], + "text": "Prostate stem cell antigen (PSCA)sprotein was assessed by western\nblot using lysates of pooled/prostate from six mice. B-Actin was used\nas a loading contral" + }, + { + "id": 67801, + "strid": "6ef3137a-46a8-497b-aec8-d8ca09a89f6e", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1243.44, + 2885.148, + 1070.9029999999998, + 460.0239999999999 + ], + "priority": 35, + "parents": [ + 67806 + ], + "children": [ + 67798 + ], + "area": 3587508.4291200005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 67798, + "strid": "674126bb-1948-420a-a874-006800a76e92", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1430.59, + 2794.01, + 722.3999999999999, + 34.121000000000095 + ], + "priority": 36, + "parents": [ + 67801 + ], + "children": [], + "area": 3997082.7659, + "iscrowd": 0, + "segmentation": [], + "text": "Fig.5 The n’RNA expression levels of AR target genes" + }, + { + "id": 67794, + "strid": "90563d70-0d39-4ee4-acd8-73b64fc00ebf", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1253.503, + 3381.928, + 1077.691, + 57.597999999999956 + ], + "priority": 37, + "parents": [ + 67806 + ], + "children": [], + "area": 4239256.893784, + "iscrowd": 0, + "segmentation": [], + "text": "The mRNA expression levels were normalized by expression levels of 18S rRNA. Data’are@,shown as mean = S. E. M. (n = 6) of three independent\ndeterminations, each performed in duplicate. *P < 0.05, **P < 0.01 versus WT mice. SBP, spermine binding protein; PRKCD, protein kinase c delta; DDT, D-\ndopachrome tautomerase" + }, + { + "id": 67802, + "strid": "b0433823-95b5-4ead-acdd-ab5150a45265", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2425.864, + 2897.91, + 797.6619999999998, + 472.33899999999994 + ], + "priority": 38, + "parents": [ + 67806 + ], + "children": [ + 67799 + ], + "area": 7029935.54424, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 67799, + "strid": "eba6884f-b686-4838-9af0-89be4237c5d4", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2486.65, + 2794.394, + 665.5279999999998, + 34.50500000000011 + ], + "priority": 39, + "parents": [ + 67802 + ], + "children": [], + "area": 6948679.8401, + "iscrowd": 0, + "segmentation": [], + "text": "Fig: 6 AR binding to promoter region of Sbp gene" + }, + { + "id": 67795, + "strid": "b0d0bdda-db9a-4fbe-a393-9a3ddc3c1d2a", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2367.085, + 3381.714, + 886.3249999999998, + 75.33300000000008 + ], + "priority": 40, + "parents": [ + 67806 + ], + "children": [], + "area": 8004804.48369, + "iscrowd": 0, + "segmentation": [], + "text": "ChIP assay was performed for WT and KO mice using antirAR antibody. Prostate tissues from five mice in each group were pooled\nand subjected to the assay. The immunoprecipitated DNA)aléhg with the DNA isolated before immunoprecipitation (input), were\nanalyzed by quantitative PCR. Signals were normalized by inpUt,DNA. Data are shown as means ~ S. D. of triplicate determination.\n**P < 0.01 versus WT mice" + }, + { + "id": 67790, + "strid": "fa43e151-4fe5-407d-bb22-ba69051040a8", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 279.685, + 3497.289, + 1294.976, + 48.927999999999884 + ], + "priority": 41, + "parents": [ + 67806 + ], + "children": [], + "area": 978139.2739650001, + "iscrowd": 0, + "segmentation": [], + "text": "Effects of Cyp3a deficiencyon lipid homeostasis in the prostates" + }, + { + "id": 67788, + "strid": "8484395f-4914-4040-ba13-73376f331651", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 79.378, + 3661.624, + 759.429, + 858.21 + ], + "priority": 42, + "parents": [ + 67806 + ], + "children": [ + 67784 + ], + "area": 290652.38987199997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 67784, + "strid": "2962f1cd-e479-475c-94f5-07c15553abdc", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 60.665, + 3604.859, + 802.969, + 33.46399999999994 + ], + "priority": 43, + "parents": [ + 67788 + ], + "children": [], + "area": 218688.771235, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 7 Expression levels of SCAP and target genes of SREBPs" + }, + { + "id": 67781, + "strid": "f63d160b-0a9f-467a-987c-88a25adda43b", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 47.151, + 4562.479, + 828.8, + 55.485999999999876 + ], + "priority": 44, + "parents": [ + 67806 + ], + "children": [], + "area": 215125.44732900002, + "iscrowd": 0, + "segmentation": [], + "text": "The mRNA expression levels were normalized by expression levels of 18S rRNA. Data are show asmeéan = S. E. M. (n\n6) of three independent determinations, each performed in duplicate. *P < 0.05, **P < 0,04\"and ***P < 0.001 versus WT\nmice." + }, + { + "id": 67789, + "strid": "800f1c78-2d19-4215-aaea-1dee7a46d514", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 959.72, + 3689.432, + 745.0800000000002, + 419.9949999999999 + ], + "priority": 45, + "parents": [ + 67806 + ], + "children": [ + 67785 + ], + "area": 3540821.67904, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 67785, + "strid": "cebdf73c-c371-4be9-8696-1ca346cc60b4", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1029.707, + 3604.256, + 682.021, + 33.110999999999876 + ], + "priority": 46, + "parents": [ + 67789 + ], + "children": [], + "area": 3711327.6329920003, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 8 Expression levels of cholesterol transportefs" + }, + { + "id": 67787, + "strid": "3c07e979-0cbd-4ece-95cc-943d41f3d84e", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 933.272, + 4125.385, + 873.2519999999998, + 39.05699999999979 + ], + "priority": 47, + "parents": [ + 67806 + ], + "children": [], + "area": 3850106.3097200003, + "iscrowd": 0, + "segmentation": [], + "text": "The mRNA expression levels were normalized by expression levels of 18S rRNA. Data are shown as mean = S. E. M. (n\nthree independent determinatidns, each performed in duplicate. *P < 0.05 versus WT mice." + }, + { + "id": 67783, + "strid": "13ac24d0-a67c-4216-b28a-918726d17cdb", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 922.234, + 4272.183, + 894.978, + 276.01800000000003 + ], + "priority": 48, + "parents": [ + 67806 + ], + "children": [ + 67786 + ], + "area": 3939952.416822, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 67786, + "strid": "7c9eb66c-6730-416c-8323-788fc7b50d63", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1216.689, + 4209.526, + 304.5830000000001, + 34.162999999999556 + ], + "priority": 49, + "parents": [ + 67783 + ], + "children": [], + "area": 5121683.979414, + "iscrowd": 0, + "segmentation": [], + "text": "Table 2 Lipid contents" + }, + { + "id": 67782, + "strid": "12f7459e-0e72-453e-9a29-9fd4088509d1", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 933.689, + 4561.929, + 872.243, + 78.00500000000011 + ], + "priority": 50, + "parents": [ + 67806 + ], + "children": [], + "area": 4259422.926081, + "iscrowd": 0, + "segmentation": [], + "text": "Non-esterified forms of fatty acid and cholesterol levels were measured using pooled tissue fromsix mige. Data for the lipid\ncontents in prostate and plasma represent the mean ~ S. D. of triplicate determination and mean, +S, E. M. of six mice in each\ngroup, respectively. In quantification of free fatty acid levels, oleic acid was used as the standart *P’< 0.05 and *#P < 0.01\nversus WT mice. ABCA1, ATP-binding cassette A1; ABCG1, ATP-binding cassette G1" + }, + { + "id": 67779, + "strid": "4d93a0f4-a160-4fa6-89a0-fad5fdb791fc", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1888.791, + 3561.528, + 489.9570000000001, + 661.721 + ], + "priority": 51, + "parents": [ + 67806 + ], + "children": [], + "area": 6726982.032647999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 67776, + "strid": "d3f5b2a6-9add-477e-aa2e-f4e1f1e13388", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2420.051, + 3493.477, + 282.4850000000001, + 50.996999999999844 + ], + "priority": 52, + "parents": [ + 67826 + ], + "children": [ + 67778 + ], + "area": 8454392.507327, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion" + }, + { + "id": 67778, + "strid": "0cb15322-d144-49a7-94ff-ce7f158fbed7", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2393.064, + 3560.311, + 878.8830000000003, + 836.3420000000001 + ], + "priority": 53, + "parents": [ + 67776 + ], + "children": [], + "area": 8520052.082904, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 67777, + "strid": "82aa986e-d7d4-448b-9e73-74889e9dd7d1", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2428.416, + 4410.045, + 293.7159999999999, + 51.60499999999956 + ], + "priority": 54, + "parents": [ + 67826 + ], + "children": [ + 67780 + ], + "area": 10709423.838720001, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion" + }, + { + "id": 67780, + "strid": "e2af955d-dec1-4742-8596-359bd8960392", + "image_id": 203155, + "image_name": "119796.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1887.213, + 4483.255, + 1377.387, + 181.10599999999977 + ], + "priority": 55, + "parents": [ + 67777 + ], + "children": [], + "area": 8460857.118315, + "iscrowd": 0, + "segmentation": [], + "text": "Cyp3a deficiency activates AR in the prostate by repressing the deactivation of\ntestosterone to 6B-hydroxytestosterone, and stimulating the activation to DHT.\nActivated AR may trigger increased mRNA expression levels of enzymes involved in\nlipid synthesis through SCAP activationin the prostates of Cyp3a’ mice." + }, + { + "id": 29370, + "strid": "0b28fa02-b71f-499c-a188-339db715a5ae", + "image_id": 201659, + "image_name": "117475.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 365.95, + 63.11, + 170.10999999999996, + 150.08999999999997 + ], + "priority": -1, + "parents": [], + "children": [ + 29364, + 29339, + 29363, + 29340, + 29342, + 29332, + 29365, + 29333, + 29356, + 29337, + 29338, + 29351, + 29355 + ], + "area": 23095.104499999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 29332, + "strid": "2a94ddac-8cbe-4ac7-a74d-e74e48731c30", + "image_id": 201659, + "image_name": "117475.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 649.332, + 102.062, + 4268.293, + 134.29199999999997 + ], + "priority": 1, + "parents": [ + 29370 + ], + "children": [], + "area": 66272.122584, + "iscrowd": 0, + "segmentation": [], + "text": "PGD, Promotes" + }, + { + "id": 191891, + "strid": "fe3b39c1-ad13-4369-8ed0-7e700df91f2e", + "image_id": 207993, + "image_name": "9207.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 163.662, + 484.102, + 372.08399999999995, + 58.17700000000002 + ], + "priority": 3, + "parents": [ + 191907 + ], + "children": [ + 191900 + ], + "area": 79229.101524, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 191900, + "strid": "fae064c9-64cc-4e16-86c0-919bacbde0fe", + "image_id": 207993, + "image_name": "9207.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 161.68, + 587.548, + 1258.127, + 1580.177 + ], + "priority": 4, + "parents": [ + 191891 + ], + "children": [], + "area": 94994.76064000001, + "iscrowd": 0, + "segmentation": [], + "text": "The state of Jnarkhand came into existence by\nbifurcating the Bihar state in the year 2000. It is the\nforest hub and is rich in mineral resources contributing\nto tune of 40% of the India’s mineral resources.\nHowever, as per UNDP, out of 33 million population,\n12.62 million are poor and 57% of the children who are\nless than five years are under malnutrition. Though\n80% of the population are involved in farming, only\n32% of the area is under net sown out of which only\n12% is irrigated. The per capita availability of food\ngrains is 546g but then the accessibility of the same is\nin question as 39% of the population live under below\npoverty line earning $ 1 a day (as purchasing power\nparity). Due to various socioeconomic constraints, only\n1/4» of the net sown area is utilized in Rabi and most\nof the lands are left as fallow. In the year 2000-01,\nRabi pulses (blackgram, chickpea, field pea,\ngreengram, horsegram, sweet pea and lentil)\nproduction was 3 lakh tonnes and the area was 6 lakh\nhectares. From the year 2010-11 onwards, the\nNational Food Security Mission - Pulses is being\nimplemented in all the 24 districts of the stateAt this\nbackdrop, this paper attempts to find out what are the\npossible drivers for the increase in area and production\nof pulses in the state of Jharkhand." + }, + { + "id": 191894, + "strid": "4646e67c-beb2-4302-a09e-18a2131f4ca5", + "image_id": 207993, + "image_name": "9207.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 170.192, + 2263.991, + 716.189, + 62.034999999999854 + ], + "priority": 5, + "parents": [ + 191907 + ], + "children": [ + 191903, + 191898 + ], + "area": 385313.156272, + "iscrowd": 0, + "segmentation": [], + "text": "Results and Discussion" + }, + { + "id": 191903, + "strid": "23c25dd5-1215-452d-91a3-5f13f3c0c283", + "image_id": 207993, + "image_name": "9207.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 168.052, + 2369.648, + 1244.253, + 2973.3229999999994 + ], + "priority": 6, + "parents": [ + 191894 + ], + "children": [], + "area": 398224.085696, + "iscrowd": 0, + "segmentation": [], + "text": "The stage of ground water development (ratio of\nannual ground water draft and net annual ground\nwater availability in percentage) is 30% for Jnarkhand\nwhereas, the all India is 58%. Improved irrigation\nsystem is being implemented under Rastriya Krishi\nVikas Yojna since 2009-10 and Waste Land & Rice\nFallow Development Program since 2010-11. Under\nthe micro irrigation scheme which is in operation since\n2005-06, assistance is being provided to the farmers\nto the tune of 90% of the unit cost. Currently, the area\nunder micro irrigation is approximately 16,000\nhectares and it is expected to raise to 90,000 hectares\nby 2017-18. At this backdrop, this paper attempts to\nfind out what are the possible drivers for the increase\nin area and production of pulses in the state of\nJharkhand. In the year 2000-01, Rabi pulses\n(blackgram, chickpea, field pea, greengram,\nhorsegram, sweet pea and lentil) production was 3\nlakh tonnes and the area was 6 lakh hectares. From\nthe year 2010-11 onwards, the National Food Security\nMission - Pulses is being implemented in all the 24\ndistricts of the state under which, high yielding\nvarieties seeds are being distributed, field\ndemonstrations were being carried out, farmer training\nprograms are being organised to increase the area,\nproduction and productivity of pulses. During the year\n2013-14 the pulses production had increased to 8\nlakh tonnes and the area expanded to 11 lakh\nhectares, which is almost triplicated produce with a\ndoubled up area. The area under chickpea during\n2009-10 was 0.630 lakh hectares and it had\nincreased to 1.558 lakh hectares in 2013-14 which is\nalmost double and the production was increased from\n0.576 lakh tonnes to 1.817 lakh tonnes. For this\nremarkable achievement, Krishi Karman Award\ninstituted by the Ministry of Agriculture and Farmers\nWelfare, Government of India was awarded to the\nstate of Jharkhand consecutively for the years 201 1-\n12 and 2012-13 in the category of pulses. The state\nhad 40% increased production compared to previous\nyears and more than 30% increased productivity than\nall India average. Minimum support price (MSP) for\nthe chickpea was ¥ 2100 per quintal during 2010-11\nand it was increased to ¥ 3175 per quintal in 2014-15.\nNow, it is further increased to ¥ 3425. For lentil, it was\n¥ 2250 in 2010-11, increased to ¥ 3075 during 2014-\n15 and now for the year 2015-16, it is ¥ 3325." + }, + { + "id": 191898, + "strid": "b6d99ebe-fad8-41e3-bbca-b6387d0d6406", + "image_id": 207993, + "image_name": "9207.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 334.109, + 5368.055, + 852.9760000000001, + 512.5290000000005 + ], + "priority": 7, + "parents": [ + 191894 + ], + "children": [], + "area": 1793515.487995, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 191892, + "strid": "2fde0fd4-d327-427e-a540-45b04f00dd2d", + "image_id": 207993, + "image_name": "9207.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1492.405, + 488.501, + 326.413, + 71.98800000000006 + ], + "priority": 8, + "parents": [ + 191907 + ], + "children": [ + 191901 + ], + "area": 729041.3349049999, + "iscrowd": 0, + "segmentation": [], + "text": "Objectives" + }, + { + "id": 191901, + "strid": "f1e6c78f-489d-4623-a033-85993d2c2058", + "image_id": 207993, + "image_name": "9207.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1490.922, + 594.752, + 1368.6, + 175.812 + ], + "priority": 9, + "parents": [ + 191892 + ], + "children": [], + "area": 886728.841344, + "iscrowd": 0, + "segmentation": [], + "text": "This paper attempts to find out what are the possible drivers\nfor the increase in area and production of pulses in the state\nof Jharkhand." + }, + { + "id": 191893, + "strid": "cc08676b-e09a-4334-be44-b24337349fb7", + "image_id": 207993, + "image_name": "9207.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1491.361, + 808.044, + 284.21699999999987, + 59.53200000000004 + ], + "priority": 10, + "parents": [ + 191907 + ], + "children": [ + 191899, + 191902, + 191906, + 191905 + ], + "area": 1205085.307884, + "iscrowd": 0, + "segmentation": [], + "text": "Materials" + }, + { + "id": 191902, + "strid": "3cbbb012-f965-4642-9674-dd133f249daa", + "image_id": 207993, + "image_name": "9207.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1491.594, + 911.525, + 1371.1679999999997, + 188.90199999999993 + ], + "priority": 11, + "parents": [ + 191893 + ], + "children": [], + "area": 1359625.22085, + "iscrowd": 0, + "segmentation": [], + "text": "A survery was made and the data and information related to\nthe pulses cultivation, production was collected and collated\nfor preparation of this paper." + }, + { + "id": 191905, + "strid": "6c544c2c-b094-4790-a7c5-d8a384929206", + "image_id": 207993, + "image_name": "9207.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1500.33, + 1177.557, + 1420.176, + 890.0759999999998 + ], + "priority": 12, + "parents": [ + 191893 + ], + "children": [], + "area": 1766724.09381, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 191899, + "strid": "a9e2123d-3e70-41de-803e-8fca3b49995d", + "image_id": 207993, + "image_name": "9207.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1499.749, + 2144.06, + 1430.6699999999998, + 1063.9469999999997 + ], + "priority": 13, + "parents": [ + 191893 + ], + "children": [], + "area": 3215551.84094, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 191906, + "strid": "018d9fab-1415-49d0-aea5-a482508b5b11", + "image_id": 207993, + "image_name": "9207.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1504.996, + 3258.017, + 1414.871, + 1052.3400000000001 + ], + "priority": 14, + "parents": [ + 191893 + ], + "children": [], + "area": 4903302.552932, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 191895, + "strid": "1048fc34-1e7f-4ec8-a92a-f65a647789d7", + "image_id": 207993, + "image_name": "9207.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1493.254, + 4350.292, + 343.55500000000006, + 56.034999999999854 + ], + "priority": 15, + "parents": [ + 191907 + ], + "children": [ + 191904 + ], + "area": 6496090.930168, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion" + }, + { + "id": 191904, + "strid": "c7791a77-6aa1-4c81-aec9-ef3db67505f0", + "image_id": 207993, + "image_name": "9207.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1492.237, + 4451.358, + 1414.804, + 1012.4930000000004 + ], + "priority": 16, + "parents": [ + 191895 + ], + "children": [], + "area": 6642481.107846, + "iscrowd": 0, + "segmentation": [], + "text": "Now the question is was it due to higher MSP announced for\nRabi pulses by the government or due to the facilitation of the\nirrigation, supply of seeds and inputs, advice and the\nmarketability contributed to the increase in area and\nproduction of pulses? The answer is that all the factors had\ncontributed but the availability of water played a major role. It\nis interesting to learn that a construction of an earthen dam in\nthe village Dalgando, District Giridih brought 15 acre area\nunder irrigation enabled the farmers to grow two or more\ncrops in a year and earn total annual income of one lakh! Now\nwith the Pradhan Mantri Krishi Sinchayee Yojana, the vision\nof for the second Green Revolution from the eastern region of\nIndia, establishment of community seed banks, making\navailable quality seeds & improved agronomic practices, and\nbetter price support would further encourage farmers to\nincrease the pulses production in the region." + }, + { + "id": 191896, + "strid": "710fdb96-18b7-4950-93d7-fecfa2c68c81", + "image_id": 207993, + "image_name": "9207.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1492.819, + 5552.565, + 926.337, + 60.72599999999966 + ], + "priority": 17, + "parents": [ + 191907 + ], + "children": [], + "area": 8288974.530734999, + "iscrowd": 0, + "segmentation": [], + "text": "Name and Contact Information" + }, + { + "id": 27081, + "strid": "da12845b-bb00-4341-859c-56a7b89574ff", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 47.7, + 51.7, + 127.39, + 315.12 + ], + "priority": -1, + "parents": [], + "children": [ + 27040, + 27034, + 27038, + 27036, + 27033, + 27041, + 27039, + 27035, + 27037 + ], + "area": 2466.09, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 27033, + "strid": "9ac96a89-d870-4db8-8c78-326fab1dd7e6", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 1453.584, + 147.482, + 2689.9040000000005, + 101.93300000000002 + ], + "priority": 1, + "parents": [ + 27081 + ], + "children": [], + "area": 214377.475488, + "iscrowd": 0, + "segmentation": [], + "text": "Overt Fixations Reflect a Natural Central Bias" + }, + { + "id": 27034, + "strid": "1f3fda75-7cef-40c8-b56a-a55c384fb62e", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1873.245, + 369.668, + 1868.217, + 170.341 + ], + "priority": 2, + "parents": [ + 27081 + ], + "children": [], + "area": 692478.73266, + "iscrowd": 0, + "segmentation": [], + "text": "Calden Wloka and John K. Tsotsos\n\nDepartment of Electrical Engineering and Computer Science, York University, Toronto, Canada\nCentre for Vision Research, York University, Toronto, Canada" + }, + { + "id": 27035, + "strid": "7d29f89a-3dc8-443c-93bc-cc805d044252", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 460.458, + 614.298, + 474.88999999999993, + 57.13499999999999 + ], + "priority": 3, + "parents": [ + 27081 + ], + "children": [ + 27042 + ], + "area": 282858.42848400003, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 27042, + "strid": "7432ab9e-6cf4-45cd-aa5b-705cf7bcdaa2", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 45.378, + 691.011, + 1306.293, + 553.4740000000002 + ], + "priority": 4, + "parents": [ + 27035 + ], + "children": [], + "area": 31356.697158, + "iscrowd": 0, + "segmentation": [], + "text": "A common characteristic of psychophysical eye-tracking data taken during free-\nviewing conditions is a strong central bias in the set of fixation locations. Although\ntrends in photographic composition may contribute to a centralized distribution of\nfixations, it does not appear to account for the entire phenomenon [1]. We propose\nthat a more fundamental explanation arises from a train of explicit overt fixations.\nWe show first that a 2D random walk implicitly encodes a central bias around the\nstarting location, and compare the statistical spread of fixation points with human\npsychophysical data. Based on the principles of our statistical results, we\nimplement a saccade controller for overt fixation control. Using the saccade\ncontroller in conjunction with the AIM saliency algorithm, [2], (which does not\ncontain a central bias component) we demonstrate an improved performance in\nreproducing more human-like fixation patterns." + }, + { + "id": 27036, + "strid": "b8916fcc-790c-4916-99b5-25fdd485563c", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 194.805, + 1305.52, + 1007.7919999999999, + 62.596000000000004 + ], + "priority": 5, + "parents": [ + 27081 + ], + "children": [ + 27052, + 27045, + 27074, + 27076, + 27050, + 27048, + 27046, + 27043, + 27075, + 27044 + ], + "area": 254321.8236, + "iscrowd": 0, + "segmentation": [], + "text": "2. Fixations as a Random Walk" + }, + { + "id": 27043, + "strid": "52bd47b9-35d5-4249-97d3-ceee08f26f6a", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 47.462, + 1386.071, + 1258.883, + 132.837 + ], + "priority": 6, + "parents": [ + 27036 + ], + "children": [], + "area": 65785.701802, + "iscrowd": 0, + "segmentation": [], + "text": "In the absence of any knowledge about the image statistics or appearance, a\nfixation train may be roughly approximated as a random walk over a constrained\n2D plane." + }, + { + "id": 27044, + "strid": "2ba50fbd-5634-4069-96ed-9b2500864122", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 102.293, + 1726.988, + 336.354, + 223.586 + ], + "priority": 7, + "parents": [ + 27036 + ], + "children": [], + "area": 176658.783484, + "iscrowd": 0, + "segmentation": [], + "text": "Fixation data formed\nby a series of random\nwalks forms a\nunimodal distribution\n(Figures | and 2)" + }, + { + "id": 27046, + "strid": "25478154-ecd0-4786-80fe-f11585fbd9a5", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 525.358, + 1575.319, + 810.9179999999999, + 628.79 + ], + "priority": 8, + "parents": [ + 27036 + ], + "children": [ + 27047 + ], + "area": 827606.4392019999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 27047, + "strid": "edc36794-866d-4b1e-bbc6-2a8a4aae1025", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 863.615, + 2212.955, + 131.47299999999996, + 33.547999999999774 + ], + "priority": 9, + "parents": [ + 27046 + ], + "children": [], + "area": 1911141.132325, + "iscrowd": 0, + "segmentation": [], + "text": "Figure |:" + }, + { + "id": 27074, + "strid": "ec25159e-167c-4088-976f-fc59ca5b1756", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 534.001, + 2252.203, + 800.48, + 110.70400000000018 + ], + "priority": 10, + "parents": [ + 27036 + ], + "children": [], + "area": 1202678.654203, + "iscrowd": 0, + "segmentation": [], + "text": "A scatter plot of randomly generated fixation sequences\nconstrained to a 1024x1024 region with a maximum step of\n200 in each direction." + }, + { + "id": 27045, + "strid": "7c6914a7-a84f-4529-9e10-fc34712937da", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 95.266, + 2268.891, + 356.883, + 273.60300000000007 + ], + "priority": 11, + "parents": [ + 27036 + ], + "children": [], + "area": 216148.17000600003, + "iscrowd": 0, + "segmentation": [], + "text": "Statistical moments,\nmy, = E(x — p)*\nprovide quantitative\n\nmeasures of\ndistribution properties!" + }, + { + "id": 27076, + "strid": "e4baf4eb-bfd4-489d-b851-ed048a615c4c", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 95.896, + 2887.609, + 358.374, + 318.06500000000005 + ], + "priority": 12, + "parents": [ + 27036 + ], + "children": [], + "area": 276910.152664, + "iscrowd": 0, + "segmentation": [], + "text": "For practical purposes,\ndistributions which\ncorrespond in the first\nfour moments may\nserve as strong\napproximations for\neach other [3]" + }, + { + "id": 27048, + "strid": "00b0f425-bc8d-41e0-b996-81147099684d", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 595.291, + 2471.989, + 722.4710000000001, + 621.3879999999999 + ], + "priority": 13, + "parents": [ + 27036 + ], + "children": [ + 27049 + ], + "area": 1471552.803799, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 27049, + "strid": "e99a9347-3c6c-4417-a264-36b7b8c56bf3", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 883.23, + 3122.717, + 127.625, + 32.427000000000135 + ], + "priority": 14, + "parents": [ + 27048 + ], + "children": [], + "area": 2758077.3359100004, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2:" + }, + { + "id": 27075, + "strid": "8fe2d226-2e7d-4904-9ec1-3fd625ee28aa", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 568.393, + 3162.308, + 759.6500000000001, + 76.85199999999986 + ], + "priority": 15, + "parents": [ + 27036 + ], + "children": [], + "area": 1797433.731044, + "iscrowd": 0, + "segmentation": [], + "text": "A histogram of the data from Figure | using 32 bins. The\ndistribution forms a unimodal peak." + }, + { + "id": 27050, + "strid": "9649787d-7360-4713-880d-e9f58f50865a", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 139.101, + 3357.715, + 1115.172, + 178.47400000000016 + ], + "priority": 16, + "parents": [ + 27036 + ], + "children": [ + 27051 + ], + "area": 467061.51421500003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 27051, + "strid": "e95ff87a-28dd-4336-a713-49b52c08f94e", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 237.229, + 3554.01, + 924.1769999999999, + 66.86299999999983 + ], + "priority": 17, + "parents": [ + 27050 + ], + "children": [], + "area": 843114.2382900001, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1: Chart of distributional moments in the x and y directions for\nrandom walk data." + }, + { + "id": 27052, + "strid": "1e46464c-5b0e-4e0f-8dfa-47302ad7ee46", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 149.059, + 3721.352, + 1083.864, + 86.64300000000003 + ], + "priority": 18, + "parents": [ + 27036 + ], + "children": [], + "area": 554701.007768, + "iscrowd": 0, + "segmentation": [], + "text": "Random walk data forms a distribution almost identical to a Gaussian\ndistribution except a slightly broader peak (kurtosis < 0)." + }, + { + "id": 27037, + "strid": "dbbfd561-5cce-4388-a7cd-9e7320ece820", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1627.245, + 611.241, + 925.2469999999998, + 59.27099999999996 + ], + "priority": 19, + "parents": [ + 27081 + ], + "children": [ + 27056, + 27062, + 27060, + 27057, + 27077, + 27061, + 27058, + 27054 + ], + "area": 994638.8610449999, + "iscrowd": 0, + "segmentation": [], + "text": "3. Human Fixation Statistics" + }, + { + "id": 27054, + "strid": "2db47e49-c3f8-4ddd-8094-0a10705748ef", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1439.486, + 690.291, + 1297.1869999999997, + 227.96799999999996 + ], + "priority": 20, + "parents": [ + 27037 + ], + "children": [], + "area": 993664.2304260002, + "iscrowd": 0, + "segmentation": [], + "text": "Judd et al. provide a large (1003 images) and useful psychophysical eye-tracking\ndata set from which human fixation statistics may be examined [4]. Judd et al. took\ntheir recorded subject fixations and turned them into saliency maps by convolving\nthe fixation point maps with a Gaussian kernel; the average of these maps produces\na strongly centralized blob of high salience as shown in Figure 3." + }, + { + "id": 27056, + "strid": "360eb240-a2ed-4258-858d-4ef0a44eedc1", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1471.823, + 976.643, + 1249.224, + 956.943 + ], + "priority": 21, + "parents": [ + 27037 + ], + "children": [ + 27055 + ], + "area": 1437445.6301890002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 27055, + "strid": "93a4f26d-b68d-4a51-8a88-218fc3dbd150", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1999.691, + 1952.949, + 129.96299999999997, + 33.32899999999995 + ], + "priority": 22, + "parents": [ + 27056 + ], + "children": [], + "area": 3905294.538759, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3:" + }, + { + "id": 27077, + "strid": "5a5f6554-657f-43cd-8584-b5f607d15526", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1515.76, + 1994.443, + 1105.8620000000003, + 31.66599999999994 + ], + "priority": 23, + "parents": [ + 27037 + ], + "children": [], + "area": 3023096.92168, + "iscrowd": 0, + "segmentation": [], + "text": "Average of human saliency maps taken from the dataset provided by Judd et al. [4]" + }, + { + "id": 27057, + "strid": "624d1b80-e577-4470-9fca-a9c11c46a233", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1504.029, + 2130.201, + 1195.982, + 78.41300000000001 + ], + "priority": 24, + "parents": [ + 27037 + ], + "children": [], + "area": 3203884.079829, + "iscrowd": 0, + "segmentation": [], + "text": "Raw fixation data can be interpreted as a distribution about the image centre.\nStatistical moments for this distribution are shown in Table 2." + }, + { + "id": 27058, + "strid": "644a9805-5b45-4940-9381-57ba4a37b108", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1521.953, + 2338.936, + 1116.134, + 180.38499999999976 + ], + "priority": 25, + "parents": [ + 27037 + ], + "children": [ + 27059 + ], + "area": 3559750.662008, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 27059, + "strid": "b01da89c-3759-4b41-99d9-ef4545042dfd", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1558.383, + 2538.883, + 1024.3590000000002, + 73.70600000000013 + ], + "priority": 26, + "parents": [ + 27058 + ], + "children": [], + "area": 3956552.106189, + "iscrowd": 0, + "segmentation": [], + "text": "Table 2: Chart of distributional moments in the x and y directions for human\npsychophysical data." + }, + { + "id": 27060, + "strid": "7019af5b-2e44-460d-994e-0ce218892005", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1490.059, + 2714.462, + 1216.6030000000003, + 131.288 + ], + "priority": 27, + "parents": [ + 27037 + ], + "children": [], + "area": 4044708.533258, + "iscrowd": 0, + "segmentation": [], + "text": "The psychophysical data has a small variance and high kurtosis, and therefore\nan even sharper central peak than in either a random walk or a Gaussian\ndistribution" + }, + { + "id": 27061, + "strid": "76891371-d233-4af7-abc1-e8ac5d24b8f3", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1495.061, + 3002.045, + 1217.8529999999998, + 87.52500000000009 + ], + "priority": 28, + "parents": [ + 27037 + ], + "children": [], + "area": 4488240.399745, + "iscrowd": 0, + "segmentation": [], + "text": "The spread of fixation points is distinctly broader in the x-direction than in the\ny-direction" + }, + { + "id": 27062, + "strid": "b715cf9f-8392-4cb8-a393-08ed09e85f01", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1472.554, + 3294.63, + 1247.862, + 508.89699999999993 + ], + "priority": 29, + "parents": [ + 27037 + ], + "children": [], + "area": 4851520.58502, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 27038, + "strid": "71a4c2ea-9ca2-42e7-a979-9e2a927765c4", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2951.997, + 610.698, + 1090.505, + 68.74199999999996 + ], + "priority": 30, + "parents": [ + 27081 + ], + "children": [ + 27066, + 27064, + 27070, + 27068, + 27067, + 27080, + 27063, + 27079, + 27078 + ], + "area": 1802778.6639059999, + "iscrowd": 0, + "segmentation": [], + "text": "4. Peripheral Saliency Map Model" + }, + { + "id": 27063, + "strid": "a70b04bd-5b2b-4937-ae43-56fcab9ab56b", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2852.156, + 688.427, + 1257.0550000000003, + 131.44399999999996 + ], + "priority": 31, + "parents": [ + 27038 + ], + "children": [], + "area": 1963501.198612, + "iscrowd": 0, + "segmentation": [], + "text": "A saccade controller is shown in Figure 4. This is a model developed as part of a\nlarger effort to understand human visual attention (see [7] for a more complete\ndescription), but also provides a useful test platform." + }, + { + "id": 27064, + "strid": "955f535b-3122-4db4-92eb-892abd1ecf5a", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2881.511, + 902.155, + 1177.6399999999999, + 891.471 + ], + "priority": 32, + "parents": [ + 27038 + ], + "children": [ + 27065 + ], + "area": 2599569.556205, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 27065, + "strid": "1d2813bc-223f-41ff-a7fa-4a4b4a915ca7", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 3422.48, + 1823.534, + 126.94900000000007, + 32.95399999999995 + ], + "priority": 33, + "parents": [ + 27064 + ], + "children": [], + "area": 6241008.64432, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 4:" + }, + { + "id": 27078, + "strid": "0370fb57-afdd-447a-b675-146addb3b992", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2955.244, + 1863.617, + 1065.185, + 114.36500000000001 + ], + "priority": 34, + "parents": [ + 27038 + ], + "children": [], + "area": 5507442.957548, + "iscrowd": 0, + "segmentation": [], + "text": "Peripheral Saliency Map Model (PSMM) to control sequence of overt fixations.\nAIM was used to provide the Peripheral Priority Map (13°x11°) and the central\nfield was approximated at roughly foveal size (2°). Figure modified from [7]" + }, + { + "id": 27066, + "strid": "af43bf98-af43-4803-9584-84fa59c80850", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2873.416, + 2117.728, + 1236.375, + 614.3760000000002 + ], + "priority": 35, + "parents": [ + 27038 + ], + "children": [], + "area": 6085113.518848, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 27067, + "strid": "6776e63b-a7c8-45b1-b41b-1618c1958e90", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2867.408, + 2911.57, + 1270.877, + 180.61099999999988 + ], + "priority": 36, + "parents": [ + 27038 + ], + "children": [], + "area": 8348659.11056, + "iscrowd": 0, + "segmentation": [], + "text": "The PSMM fixation controller was tested against the pure AIM algorithm [2] on\n501 randomly selected images from Judd et al.’s dataset [3]. An example image is\nshown in Figure 5, performance of the two algorithms is shown in Figure 6.\nPSMM increased the fidelity of fixations to those of humans by 10.84%." + }, + { + "id": 27068, + "strid": "542ff61e-d07a-4ce5-af5e-806a615cfb35", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2942.203, + 3183.771, + 1108.078, + 640.587 + ], + "priority": 37, + "parents": [ + 27038 + ], + "children": [ + 27069 + ], + "area": 9367300.587513, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 27069, + "strid": "1ce89325-cf6c-4b3d-868a-a7bc58b55be4", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 3517.509, + 3520.0, + 140.69700000000012, + 40.621999999999844 + ], + "priority": 38, + "parents": [ + 27068 + ], + "children": [], + "area": 12381631.68, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 5:" + }, + { + "id": 27080, + "strid": "2a119888-68ca-4356-a94d-b5fad54a3620", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3516.473, + 3567.047, + 514.9189999999999, + 203.5680000000002 + ], + "priority": 39, + "parents": [ + 27038 + ], + "children": [], + "area": 12543424.465231, + "iscrowd": 0, + "segmentation": [], + "text": "PSMM fixation results are shown\nin the upper left, AIM fixation\nresults are shown in the upper\nright. Human fixations from [3] are\nshown in lower left." + }, + { + "id": 27070, + "strid": "bda73baa-75ed-4eb5-a896-4aaf8bf0f384", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 4284.805, + 642.336, + 1241.728, + 1003.5910000000001 + ], + "priority": 40, + "parents": [ + 27038 + ], + "children": [ + 27071 + ], + "area": 2752284.50448, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 27071, + "strid": "c3c4231f-d05a-445d-bd2c-eca08bbbd231", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 4858.287, + 1667.547, + 127.8819999999996, + 33.662000000000035 + ], + "priority": 41, + "parents": [ + 27070 + ], + "children": [], + "area": 8101421.911989001, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 6:" + }, + { + "id": 27079, + "strid": "65800b47-3492-481c-9a30-892f2f06095a", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4349.632, + 1707.572, + 1148.1090000000004, + 114.09400000000005 + ], + "priority": 42, + "parents": [ + 27038 + ], + "children": [], + "area": 7427309.813503999, + "iscrowd": 0, + "segmentation": [], + "text": "ROC results for 501 randomly selected images from Judd et al.’s dataset [3]. The\nPSMM is consistently closer to human performance than the standard AIM algorithm,\nimproving performance by 10.84%." + }, + { + "id": 27039, + "strid": "42e4300e-1ba5-4f7a-9642-4b22283264cd", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4658.487, + 1952.949, + 487.71500000000015, + 58.919000000000096 + ], + "priority": 43, + "parents": [ + 27081 + ], + "children": [ + 27072 + ], + "area": 9097787.528163001, + "iscrowd": 0, + "segmentation": [], + "text": "5 Conclusions" + }, + { + "id": 27072, + "strid": "c6a6945a-77c4-4815-8cfd-bd1edcf9b8ec", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 4276.666, + 2080.116, + 1266.643, + 683.3339999999998 + ], + "priority": 44, + "parents": [ + 27039 + ], + "children": [], + "area": 8895961.373256, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 27041, + "strid": "db123021-86ce-4e4e-965f-2644c585e5f1", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 50.67, + 3946.492, + 720.141, + 79.06100000000015 + ], + "priority": 45, + "parents": [ + 27081 + ], + "children": [ + 27053 + ], + "area": 199968.74964000002, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements:" + }, + { + "id": 27053, + "strid": "4c0d19b1-275f-462b-9f8c-1b11cc0dca89", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 57.62, + 4041.106, + 3498.0, + 84.9670000000001 + ], + "priority": 46, + "parents": [ + 27041 + ], + "children": [], + "area": 232848.52772, + "iscrowd": 0, + "segmentation": [], + "text": "Financial support was provided in part by the Ontario Graduate Scholarship (OGS) program, the Natural Science and Engineering Research Council (NSERC), and the Canada Research Chairs Program.\nAdditionally, we would like to thank Neil Bruce, Albert Rothenstein, Eugene Simine, Erich Leung, and Xun Shi for their helpful advice and discussions related to this work." + }, + { + "id": 27040, + "strid": "5c3c9ebd-caf4-4e16-be89-619c9acd01fc", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4723.115, + 2987.836, + 367.8029999999999, + 58.36499999999978 + ], + "priority": 47, + "parents": [ + 27081 + ], + "children": [ + 27073 + ], + "area": 14111893.029139997, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 27073, + "strid": "f0592454-17ae-430f-9fb8-7e5a68e05997", + "image_id": 201568, + "image_name": "117322.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 4275.194, + 3065.458, + 1263.88, + 686.654 + ], + "priority": 48, + "parents": [ + 27040 + ], + "children": [], + "area": 13105427.648852002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 118401, + "strid": "39f30c76-4dcd-46e2-9997-0860db29b4a5", + "image_id": 205106, + "image_name": "14195.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 51.42, + 85.95, + 116.8, + 332.44 + ], + "priority": -1, + "parents": [], + "children": [ + 118386, + 118384, + 118385, + 118392 + ], + "area": 4419.549, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 118384, + "strid": "9f426a46-f74b-4f79-9402-66c6c30752b6", + "image_id": 205106, + "image_name": "14195.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 218.178, + 109.641, + 3470.821, + 627.009 + ], + "priority": 1, + "parents": [ + 118401 + ], + "children": [], + "area": 23921.254098, + "iscrowd": 0, + "segmentation": [], + "text": "Evaluation of Geo-Climactic Location-of-Origin\nFeatures for Effects on Phenotype Prediction\n\nAccuracy with ML models\nA case study in Arabidopsis thaliana" + }, + { + "id": 118385, + "strid": "ba0ec3c2-2188-4c3e-bbf6-dbb9f590c237", + "image_id": 205106, + "image_name": "14195.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 550.667, + 786.576, + 3138.332, + 261.866 + ], + "priority": 2, + "parents": [ + 118401 + ], + "children": [], + "area": 433141.44619200006, + "iscrowd": 0, + "segmentation": [], + "text": "Elhan S. Ersoz\n\n@® 0000-0001-6930-6946, elhan@umbrellagenetics.org\n\nResearch Director, Umbrella Genetics, 2501 Woodridge Road, Champaign, IL, 61822" + }, + { + "id": 118386, + "strid": "b46019cd-d834-4a39-a820-f8e949f415cc", + "image_id": 205106, + "image_name": "14195.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 199.401, + 1109.743, + 344.89500000000004, + 69.52099999999996 + ], + "priority": 3, + "parents": [ + 118401 + ], + "children": [ + 118389, + 118388, + 118391, + 118387 + ], + "area": 221283.863943, + "iscrowd": 0, + "segmentation": [], + "text": "Abstract" + }, + { + "id": 118387, + "strid": "98d62ccd-ffad-45a7-ba9c-0d87d06e78f0", + "image_id": 205106, + "image_name": "14195.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 193.615, + 1192.985, + 1854.49, + 1161.961 + ], + "priority": 4, + "parents": [ + 118386 + ], + "children": [], + "area": 230979.790775, + "iscrowd": 0, + "segmentation": [], + "text": "Flowering time and most life history traits are often expected to be\nadaptive, i.e. genetic variation for these phenotypes are mostly driven\nby selective pressures and drift at the location-of-origin. Long-term\nlocation based environmental data , i.e. geo-climactic data- can be\nused for assessment of location-of-origin similarities that drive the\ngenetic adaptations for a study population.\n\nBy utilizing machine learning approaches for classification of long term\ngeo-climactic data into a handful of features for individual samples of\nthe population, one can include these characteristics into predictive\nmodels for phenotypes.\n\nIt is hypothesized that using geo-climactic features, together with\nfeatures that characterize genetic relationships within the population\n(components of G-matrix), can improve prediction accuracy with a\nRandom-Forest ML approach, for unobserved phenotypes." + }, + { + "id": 118388, + "strid": "3d02a7b7-85ff-4d56-ae18-46f10dd57f5b", + "image_id": 205106, + "image_name": "14195.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 192.694, + 2364.676, + 1776.687, + 394.12400000000025 + ], + "priority": 5, + "parents": [ + 118386 + ], + "children": [], + "area": 455658.87714399997, + "iscrowd": 0, + "segmentation": [], + "text": "Methods\n\nWe evaluated the prediction accuracies for flowering time classes early\nvs.late, and major free-amino-acids concentration levels of arginine,\nmethionine and proline divided into 4 classes based on quartile\ndistribution of their absolute levels, as phenotypes." + }, + { + "id": 118389, + "strid": "632e481f-6d44-4550-9b16-285654c8fe1c", + "image_id": 205106, + "image_name": "14195.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 185.362, + 2786.531, + 1869.069, + 1185.7849999999999 + ], + "priority": 6, + "parents": [ + 118386 + ], + "children": [ + 118390 + ], + "area": 516516.959222, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 118390, + "strid": "3fcb5704-b5a2-4429-bcf3-1323bcb97eaf", + "image_id": 205106, + "image_name": "14195.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 207.172, + 3977.106, + 1838.945, + 158.31799999999976 + ], + "priority": 7, + "parents": [ + 118389 + ], + "children": [], + "area": 823945.004232, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. Arabidopsis RegMap population environmental feature generation with cubic spline smoothing regression based on data reported by Lasky et.\nal 2012. A set of six features were generated using the 12 month profiles of the variables evaluated by cubic spline smoothing regression for each accession to identify the\ntime series profile for each of precipitation(prec.m), temperature-average(tmean.m), temperature minimum(tmin.m), temperature-maximum(tmax.m), evaporative\ndemand(vpd) and interannual precipitation(interann). A seventh feature, photosynthetically active radiation (PAR) was calculated for four seasons as seasonal averages\nwhen available. Two accessions from France, two accessions doom Sweden and one accession from Tajikistan is shown for comparison." + }, + { + "id": 118391, + "strid": "c755f32d-d345-4cb3-8ea6-8a97dee2546a", + "image_id": 205106, + "image_name": "14195.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 190.11, + 4151.61, + 1823.442, + 627.4620000000004 + ], + "priority": 8, + "parents": [ + 118386 + ], + "children": [], + "area": 789262.5771, + "iscrowd": 0, + "segmentation": [], + "text": "The data for FAA’s were obtained from Angelovici et al. 2017, and the FT\nclass data was available from Lasky et al. 2012.\n\nWe have generated 8 environmental features from the data in Lasky et al.\n2012, to characterize each individual with a feature-profile (Figure, 2).\nAdditionally we have generated 30 genetic features from eigenvalue\ndecomposition of the G-matrix generated from 250K chip data (Figure 3).\nPredictions were performed by RandomForest method implemented in R\nusing libraries caret and RandomForest" + }, + { + "id": 118392, + "strid": "659e656b-40a2-4e5d-b5f9-aa0e625c4a79", + "image_id": 205106, + "image_name": "14195.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2206.499, + 1102.043, + 295.25700000000006, + 66.80600000000004 + ], + "priority": 9, + "parents": [ + 118401 + ], + "children": [ + 118396, + 118399, + 118393, + 118394, + 118398, + 118400 + ], + "area": 2431656.7774569998, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 118393, + "strid": "70af4ce6-6ca2-4008-9aa0-ae7f1576ffd7", + "image_id": 205106, + "image_name": "14195.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2197.078, + 1187.101, + 1870.0679999999998, + 821.451 + ], + "priority": 10, + "parents": [ + 118392 + ], + "children": [], + "area": 2608153.4908780004, + "iscrowd": 0, + "segmentation": [], + "text": "Inclusion of the environmental features into the RF prediction model\nincreased the prediction accuracy for methionine, decreased the\nprediction accuracy for proline, and did not create any change for the\nprediction accuracies for arginine and flowering time classification of\nthe test samples ( early vs. late) (Table 1).\n\nVariance components attributable to each of these traits show variation\nfor their G-matrix and E-matrix attributable portions (Table 1). Although\nno conclusive trend was identified, the patterns observed are indicative\nof slight improvements for environmentally influenced, moderate to low\nheritability traits in prediction accuracies." + }, + { + "id": 118394, + "strid": "a7efaf4b-b89a-45e9-87a4-bf77b3cadb47", + "image_id": 205106, + "image_name": "14195.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2164.607, + 2034.963, + 1911.0550000000003, + 645.8839999999998 + ], + "priority": 11, + "parents": [ + 118392 + ], + "children": [], + "area": 4404895.154541, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 118398, + "strid": "f16a501a-1053-4353-8962-fd97d216d01a", + "image_id": 205106, + "image_name": "14195.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2167.326, + 2721.487, + 908.6440000000002, + 854.7240000000002 + ], + "priority": 12, + "parents": [ + 118392 + ], + "children": [ + 118395 + ], + "area": 5898349.5337620005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 118395, + "strid": "6b47563f-d85c-4501-bf7f-fc674c076a1e", + "image_id": 205106, + "image_name": "14195.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2245.669, + 3612.925, + 1810.728, + 192.59000000000015 + ], + "priority": 13, + "parents": [ + 118398 + ], + "children": [], + "area": 8113433.671825, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2. Arabidopsis RegMap population clustering and classification using hierarchical clustering on the environmental features reported by Lasky et.\nal 2012. A set of 9 features were generated using the profiles of each of the variables evaluated. Cubic spline smoothing regression was used to fit a function to the 12\nmonth profile of each accession to identify the time series profile for each of precipitation(prec.m), temperature-average(tmean.m), temperature minimum(tmin.m),\ntemperature-maximum(tmax.m), evaporative demand(vpd) and interannual precipitation(interann). Photosynthetically active radiation (PAR) was calculated for four\nseasons as seasonal averages, and aridity index (aridx) was not a time series so parameters PAR and aridx was left as they were, except centered and scaled for their\nover the population distributions. Clustering parameter km=5 is used for generating the figures, for comparability." + }, + { + "id": 118399, + "strid": "156ed562-8e48-4f3b-a3a1-a171a09ab0cd", + "image_id": 205106, + "image_name": "14195.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3077.966, + 2717.493, + 996.5120000000002, + 862.712 + ], + "priority": 14, + "parents": [ + 118392 + ], + "children": [], + "area": 8364351.059238, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 118396, + "strid": "757e022c-14a6-4fd4-9efc-ba40b55b4301", + "image_id": 205106, + "image_name": "14195.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2169.68, + 3807.857, + 993.181, + 906.7539999999999 + ], + "priority": 15, + "parents": [ + 118392 + ], + "children": [ + 118397 + ], + "area": 8261831.175759999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 118397, + "strid": "99132f03-f93d-4b10-9e36-f73f09315209", + "image_id": 205106, + "image_name": "14195.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2180.122, + 4741.419, + 1894.2800000000002, + 91.3789999999999 + ], + "priority": 16, + "parents": [ + 118396 + ], + "children": [], + "area": 10336871.873117998, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3. Arabidopsis RegMap population clustering and classification using hierarchical clustering based on 250K chip genotypes. First panels (A) shows the\nkinship matrix displayed as a heatmap, while the second panel shows the top thirty Eigenvectors from the decomposition of the K-matrix. Top thirty eigenvectors explain 26% of\nthe overall variance observed in the K-matrix. Clustering parameter km=5 is used for generating the figures, for comparability." + }, + { + "id": 118400, + "strid": "f835e929-9009-4611-9317-7b9ca4ca8ad3", + "image_id": 205106, + "image_name": "14195.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3170.305, + 3808.952, + 919.203, + 906.8640000000005 + ], + "priority": 17, + "parents": [ + 118392 + ], + "children": [], + "area": 12075539.57036, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 26992, + "strid": "0bfe9ec2-3d19-4093-a1a1-9846c9342296", + "image_id": 201566, + "image_name": "117320.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 3407.44, + 4.56, + 192.55999999999995, + 168.57 + ], + "priority": -1, + "parents": [], + "children": [ + 26963, + 26968, + 26964, + 26966, + 26970, + 26967, + 26969, + 26965 + ], + "area": 15537.926399999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 26963, + "strid": "1b966f53-c705-4a9b-86c9-19f902606a54", + "image_id": 201566, + "image_name": "117320.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 204.215, + 38.628, + 3148.871, + 104.00499999999998 + ], + "priority": 1, + "parents": [ + 26992 + ], + "children": [], + "area": 7888.41702, + "iscrowd": 0, + "segmentation": [], + "text": "Genomic collaterals of Helicobacter pylori and Ochrobactrumuntermedium" + }, + { + "id": 26964, + "strid": "4032b394-672a-4d40-8989-776b97d2f5fa", + "image_id": 201566, + "image_name": "117320.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 940.198, + 273.317, + 1683.8900000000003, + 334.76700000000005 + ], + "priority": 2, + "parents": [ + 26992 + ], + "children": [], + "area": 256972.096766, + "iscrowd": 0, + "segmentation": [], + "text": "Rashmi Singh!; Niyaz Ahmed*!\n\n(Ramani Baddam, Narender Kumar)\n\n1.Department of Biotechnology & Bioinformatics, School of Life,Sciences,\nUniyefsity of Hyderabad, Gachibowli. 500046," + }, + { + "id": 26965, + "strid": "da5591a9-f2db-4f61-9984-bcb3088741fe", + "image_id": 201566, + "image_name": "117320.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 381.778, + 743.931, + 411.722, + 57.823999999999955 + ], + "priority": 3, + "parents": [ + 26992 + ], + "children": [ + 26971 + ], + "area": 284016.48931800004, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 26971, + "strid": "fa082cd1-a3b2-4d0c-90ee-df25f6d7dfa8", + "image_id": 201566, + "image_name": "117320.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 57.306, + 846.453, + 1043.369, + 974.125 + ], + "priority": 4, + "parents": [ + 26965 + ], + "children": [], + "area": 48506.835618, + "iscrowd": 0, + "segmentation": [], + "text": "Helicobacter pylori is a Gram-negative bacterium which thrives\nin the human gut. It produces large amounts of the enzyme\nurease, which breaks down urea (which is normally secreted into\nthe stomach) to carbon dioxide and ammonia. The ammonia is\nconverted to ammonium by accepting a proton (H*), which\nneutralizes gastric acid. The survival of H. pylori in the acidic\nstomach is dependent on urease. The ammonia produced is toxic\nto the epithelial cells, and, along with the other products of H.\npylori damages those cells causing certain diseases. On the other\nhand, Ochrobactrum spp. are members of the soil microbiota.\nhowever, an increasing numberof studies have reported the\nisolation of Ochrobactrum anthropi and O. intermedium from\nclinical specimens, especially from immuno-compromised\npatients or from patients with nosocomial infections.\nInterestingly, Ochrobactrum sp. were also found to be urease\npositive and has been reported in many cases of gastric infection\ntogether with H. pylori, sharing the same niche. Being urease\npositive, it may lead to false positive urease test for H. pylori\ndetection. Herein we aimed to compare the genomes of H. pylori\nand O.-intermedium, in order to decipher their relationship at\ngenetic levels." + }, + { + "id": 26966, + "strid": "0fddbf2b-687e-4b48-a5ba-fbd45e72059f", + "image_id": 201566, + "image_name": "117320.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 392.848, + 1902.545, + 397.167, + 67.5630000000001 + ], + "priority": 5, + "parents": [ + 26992 + ], + "children": [ + 26976, + 26986, + 26975, + 26977, + 26974 + ], + "area": 747410.9981600001, + "iscrowd": 0, + "segmentation": [], + "text": "Methodology" + }, + { + "id": 26974, + "strid": "28c36914-d660-40b1-a56d-128fb3c36b4d", + "image_id": 201566, + "image_name": "117320.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 12.112, + 2006.42, + 1071.228, + 464.8299999999999 + ], + "priority": 6, + "parents": [ + 26966 + ], + "children": [], + "area": 24301.75904, + "iscrowd": 0, + "segmentation": [], + "text": "1. Genome selection and annotation\n\nDraft genomes of Ochrobactrum intermedium M86 and\nHelicobacter pylori NAD1, which is a newly sequenced genome\nwere selected. Both the genomes were annotated using RAST\nServer. Apart from these some other helicobacter and\nochrobactrum genomes and the genomes of Vibrio\nparahaemolyticus and Burkholderia pseudomallei were selected\nfor phylogenetic analysis (Tablel). The FASTA files of these\ngenomes were obtained with their NCBI genome project IDs." + }, + { + "id": 26986, + "strid": "11705766-da1d-48bf-9d90-dd46fb391c79", + "image_id": 201566, + "image_name": "117320.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 81.776, + 2656.7, + 970.3550000000001, + 1461.4679999999998 + ], + "priority": 7, + "parents": [ + 26966 + ], + "children": [ + 26980 + ], + "area": 217254.29919999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 26980, + "strid": "1a90292a-95f3-4449-8a53-375796df22c6", + "image_id": 201566, + "image_name": "117320.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 64.938, + 2534.005, + 999.7900000000001, + 85.48300000000017 + ], + "priority": 8, + "parents": [ + 26986 + ], + "children": [], + "area": 164553.21669, + "iscrowd": 0, + "segmentation": [], + "text": "Tablel. Selected species with their accession numbers taken\nfor analysis" + }, + { + "id": 26975, + "strid": "e4683bac-e8c3-4006-986b-83641b17d257", + "image_id": 201566, + "image_name": "117320.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 41.581, + 4179.955, + 1049.769, + 587.3469999999998 + ], + "priority": 9, + "parents": [ + 26966 + ], + "children": [], + "area": 173806.708855, + "iscrowd": 0, + "segmentation": [], + "text": "2. Phylogenetic analysis of ribosomal RNA\n\nThe 16S rRNA genes for all the helicobacter and ochrobactrum\ngenomes were identified using rRNA gene finder, RNAmmer\nprogram along with a vibrio genome, which is taken as an\noutgroup for the phylogenetic tree. Among the extracted\n16SrRNA gene sequences, those with a higher score predicted\nby RNAmmer were selected to construct the tree. The\nClustalW2 program for multiple sequence alignment was used\nto align the sequences. Program SplitsTree4 was then used to\nvisualize the tree with UPGMA method. 1000 bootstrap\nresamplings were done to estimate the consensus tree." + }, + { + "id": 26976, + "strid": "31881e15-ff01-4a50-8fcd-929912eeee78", + "image_id": 201566, + "image_name": "117320.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1218.493, + 746.112, + 1174.701, + 503.83000000000004 + ], + "priority": 10, + "parents": [ + 26966 + ], + "children": [], + "area": 909132.249216, + "iscrowd": 0, + "segmentation": [], + "text": "3. Phylogenetic analysis of urease-positive organisms.\n\nThe protein FASTA sequence of the urease subunit alpha protein in\nochrobactrum intermedium, which was conserved in all genomes under\nstudy were extracted using BLASTp program. The FASTA sequence of\nthe same protein in Burkholderia pseudomallei, which is also a urease\npositive organism was taken for phylogenetic analysis. ClustalW2\nprogram for multiple sequence alignment was used to align the\nsequences. Program SplitsTree4 was then used to visualize the tree\nwith UPGMA method. 1000 bootstrap resamplings were done to\nestimate the consensus tree." + }, + { + "id": 26977, + "strid": "85daead6-fa54-423f-9576-909cbdc887c9", + "image_id": 201566, + "image_name": "117320.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1215.603, + 1311.656, + 1176.531, + 331.501 + ], + "priority": 11, + "parents": [ + 26966 + ], + "children": [], + "area": 1594452.968568, + "iscrowd": 0, + "segmentation": [], + "text": "4. Core genome analysis\nThe core genome set of the Helicobacter pylori NADI and\nOchrobactrum intermedium M86 was determined using PGAP (Pan\nGenome Analysis Pipeline) tool. The core orthologous gene clusters\nalong with their annotation were identified. The cluster functional\ncharaterisation was done in order to identify the common functional\nprocesses involved in both the organisms." + }, + { + "id": 26967, + "strid": "5fe75a16-35f6-497f-9c93-681ef5a50f5e", + "image_id": 201566, + "image_name": "117320.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1713.253, + 1718.926, + 232.18599999999992, + 58.25199999999995 + ], + "priority": 12, + "parents": [ + 26992 + ], + "children": [ + 26991, + 26988, + 26978, + 26989, + 26990, + 26987 + ], + "area": 2944955.126278, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 26978, + "strid": "a61af711-9bad-4974-9fa9-2e7882b2a94c", + "image_id": 201566, + "image_name": "117320.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1253.263, + 1820.896, + 1116.592, + 273.7270000000001 + ], + "priority": 13, + "parents": [ + 26967 + ], + "children": [], + "area": 2282061.583648, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 26987, + "strid": "7b4846a6-6e60-4697-bcaa-1c185654fe10", + "image_id": 201566, + "image_name": "117320.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1152.65, + 2195.506, + 1393.3830000000003, + 969.4360000000001 + ], + "priority": 14, + "parents": [ + 26967 + ], + "children": [ + 26981 + ], + "area": 2530649.9909, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 26981, + "strid": "be38e3ce-6840-4d49-b837-f7c4517b3163", + "image_id": 201566, + "image_name": "117320.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1208.311, + 3254.443, + 885.0849999999998, + 40.39800000000014 + ], + "priority": 15, + "parents": [ + 26987 + ], + "children": [], + "area": 3932379.275773, + "iscrowd": 0, + "segmentation": [], + "text": "Fig .1: Subsystem distribution of the core genome set" + }, + { + "id": 26988, + "strid": "2068b993-965f-47d6-87ee-5e468bb6f1d4", + "image_id": 201566, + "image_name": "117320.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1340.541, + 3387.563, + 754.8900000000001, + 486.98199999999997 + ], + "priority": 16, + "parents": [ + 26967 + ], + "children": [ + 26982 + ], + "area": 4541167.091583, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 26982, + "strid": "20a22db8-6a68-46f3-9821-8d6cdcbc5b28", + "image_id": 201566, + "image_name": "117320.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1197.628, + 3946.46, + 1086.6429999999998, + 85.22600000000011 + ], + "priority": 17, + "parents": [ + 26988 + ], + "children": [], + "area": 4726390.9968799995, + "iscrowd": 0, + "segmentation": [], + "text": "Fig.2: Venn Diagram showing shared orthologous gene clusters in\nboth the organisms." + }, + { + "id": 26989, + "strid": "7703a209-bbbd-441c-95c4-e53c9b7e0e94", + "image_id": 201566, + "image_name": "117320.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1210.23, + 4070.627, + 1076.5840000000003, + 511.68499999999995 + ], + "priority": 18, + "parents": [ + 26967 + ], + "children": [ + 26983 + ], + "area": 4926394.91421, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 26983, + "strid": "5167369a-0642-4351-ba68-3c3c397a797a", + "image_id": 201566, + "image_name": "117320.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1190.676, + 4653.755, + 912.7980000000002, + 85.61399999999958 + ], + "priority": 19, + "parents": [ + 26989 + ], + "children": [], + "area": 5541114.388379999, + "iscrowd": 0, + "segmentation": [], + "text": "Fig.3: Circular Genome View of (A) Helicobacter pylori\n(B)Ochrobactrum intermedium" + }, + { + "id": 26990, + "strid": "c687965d-e364-4678-b3e2-a6cde866cfdb", + "image_id": 201566, + "image_name": "117320.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2469.386, + 786.985, + 1118.5430000000001, + 1534.7779999999998 + ], + "priority": 20, + "parents": [ + 26967 + ], + "children": [ + 26985 + ], + "area": 1943369.7412100001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 26985, + "strid": "8abb31b1-d4e3-4730-bf98-0f6af78b99a2", + "image_id": 201566, + "image_name": "117320.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2673.753, + 2379.871, + 731.8269999999998, + 86.81500000000005 + ], + "priority": 21, + "parents": [ + 26990 + ], + "children": [], + "area": 6363187.225863, + "iscrowd": 0, + "segmentation": [], + "text": "Fig4: Phylogenetic tree : (A) Urease positive\norganisms. (B) Based on 16SrRNA" + }, + { + "id": 26991, + "strid": "db858240-6306-4186-b324-b0c0f0b355ef", + "image_id": 201566, + "image_name": "117320.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2604.999, + 2607.334, + 929.7290000000003, + 684.4079999999999 + ], + "priority": 22, + "parents": [ + 26967 + ], + "children": [ + 26984 + ], + "area": 6792102.462665999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 26984, + "strid": "bdbceb66-36ae-4715-bef3-46acec76bbe0", + "image_id": 201566, + "image_name": "117320.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2649.839, + 3288.062, + 868.9299999999998, + 85.89800000000014 + ], + "priority": 23, + "parents": [ + 26991 + ], + "children": [], + "area": 8712834.922017999, + "iscrowd": 0, + "segmentation": [], + "text": "Fig.5.: Genome Alignment of Helicobacter pylori and\nOchrobactrum intermedium using MAUVE" + }, + { + "id": 26968, + "strid": "03927d36-f0fa-4161-bc64-7eec4fd6646d", + "image_id": 201566, + "image_name": "117320.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2811.479, + 3472.893, + 347.15099999999984, + 55.38200000000006 + ], + "priority": 24, + "parents": [ + 26992 + ], + "children": [ + 26972 + ], + "area": 9763965.738746999, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion" + }, + { + "id": 26972, + "strid": "fe941e75-b9d9-41e0-b5df-f037fd063cda", + "image_id": 201566, + "image_name": "117320.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2422.694, + 3582.629, + 1143.6110000000003, + 431.433 + ], + "priority": 25, + "parents": [ + 26968 + ], + "children": [], + "area": 8679613.782526, + "iscrowd": 0, + "segmentation": [], + "text": "The genomes of H. pylori and O. intermedium were compared in order\nto get a link between the species at genetic levels. The phylogenetic\ntree based on 16SrRNA and the urease alpha genes were created\nthat showed a distinct class for O. intermedium. The core genome set\nof these strains appears shared somewhat and having 584\northologous gene clusters in common and related mostly to basal\nmetabolic processes and replication along with few others entailing\npathogenesis. The functional relevance of these genes and further\npathway analysis will shed light on the coexistence of these organisms\nin the human gut ecosystem." + }, + { + "id": 26970, + "strid": "ebe42039-f387-4c10-8756-33946a01f3eb", + "image_id": 201566, + "image_name": "117320.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2698.713, + 4559.265, + 576.123, + 69.70700000000033 + ], + "priority": 26, + "parents": [ + 26992 + ], + "children": [ + 26973 + ], + "area": 12304147.725945001, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgement" + }, + { + "id": 26973, + "strid": "6dd9cda9-f4c5-4623-8d8b-cb050fde3f0d", + "image_id": 201566, + "image_name": "117320.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2433.903, + 4652.876, + 1099.469, + 127.20300000000043 + ], + "priority": 27, + "parents": [ + 26970 + ], + "children": [], + "area": 11324648.855028, + "iscrowd": 0, + "segmentation": [], + "text": "| gratefully acknowledge Dr. Niyaz Anmed, Narender Kumar, Ramani\nBaddam, Shaik Sabiha and all the Pathogen Biology Laboratory\nmembers for their constant support and guidance." + }, + { + "id": 26969, + "strid": "b1c9160a-6bac-4fca-a01c-76c112586983", + "image_id": 201566, + "image_name": "117320.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2813.92, + 4057.782, + 345.0920000000001, + 55.23099999999977 + ], + "priority": 28, + "parents": [ + 26992 + ], + "children": [ + 26979 + ], + "area": 11418273.92544, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 26979, + "strid": "6b72ab9d-9795-46c7-89d2-e7c0dcf0e9e0", + "image_id": 201566, + "image_name": "117320.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2417.414, + 4169.16, + 1123.2940000000003, + 313.97500000000036 + ], + "priority": 29, + "parents": [ + 26969 + ], + "children": [], + "area": 10078585.75224, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 156479, + "strid": "d711ccb0-9ae1-4c52-924b-1cee9b7e59b1", + "image_id": 206611, + "image_name": "23998.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 196.06, + 561.49, + 404.21999999999997, + 139.38 + ], + "priority": -1, + "parents": [], + "children": [ + 156454, + 156459, + 156460, + 156453, + 156458, + 156464, + 156478 + ], + "area": 110085.7294, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 156453, + "strid": "54e708d6-6a70-4a09-93ed-a03b81cab613", + "image_id": 206611, + "image_name": "23998.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 747.481, + 121.363, + 1960.0309999999997, + 590.694 + ], + "priority": 1, + "parents": [ + 156479 + ], + "children": [], + "area": 90716.536603, + "iscrowd": 0, + "segmentation": [], + "text": "Where there is hope: a qualitative\nstudy examining adherence to\nMDR-TB treatment in\nKarakalpakstan, Uzbekistan" + }, + { + "id": 156454, + "strid": "44f86c38-b093-4962-9127-4c3f5b9abffa", + "image_id": 206611, + "image_name": "23998.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 135.903, + 834.373, + 3096.67, + 328.163 + ], + "priority": 2, + "parents": [ + 156479 + ], + "children": [], + "area": 113393.793819, + "iscrowd": 0, + "segmentation": [], + "text": "*Shona Horter', Beverley Stringer', Jane Greig', Philipp du Cros', Sebastian Dietrich?, Mirzagaleb\nTillyashaykhov?, Parpieva Nargiza’, Zinaida Tigay*, Dilrabo Ulmasova®\n\n‘Médecins sans Frontiéres (MSF), London, UK; 7MSF Berlin, Germany; *Ministry of Health of the Republic of Uzbekistan; *TB\nI] hospital, Nukus, Uzbekistan; °SWHO, Tashkent, Uzbekistan" + }, + { + "id": 156458, + "strid": "f924fd7e-fe8c-4640-b28d-530114072efa", + "image_id": 206611, + "image_name": "23998.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 82.897, + 1236.321, + 111.051, + 52.03099999999995 + ], + "priority": 3, + "parents": [ + 156479 + ], + "children": [ + 156457, + 156455 + ], + "area": 102487.301937, + "iscrowd": 0, + "segmentation": [], + "text": "Aim" + }, + { + "id": 156455, + "strid": "232bbcaf-b1d9-4541-b233-8a5d92cde54f", + "image_id": 206611, + "image_name": "23998.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 73.254, + 1296.785, + 2064.447, + 402.74599999999987 + ], + "priority": 4, + "parents": [ + 156458 + ], + "children": [], + "area": 94994.68839000001, + "iscrowd": 0, + "segmentation": [], + "text": "Médecins sans Frontiéres (MSF) and the Ministry of Health provide a comprehensive tuberculosis (TB)\nprogramme in Karakalpakstan, Uzbekistan. Multi-drug resistant TB (MDR-TB) treatment is complex, lengthy\nand often toxic, and adherence to treatment is challenging. We aimed to provide insight into the different\npatterns of adherence that exist for patients undergoing MDR-TB treatment in Karakalpakstan, Uzbekistan,\nexploring the barriers and enablers to treatment-taking in order to inform future strategies of adherence\nsupport." + }, + { + "id": 156457, + "strid": "0ca3a8cf-eaec-4dd2-83ca-db6712b88ea3", + "image_id": 206611, + "image_name": "23998.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2265.982, + 1195.352, + 1053.1059999999998, + 548.9280000000001 + ], + "priority": 5, + "parents": [ + 156458 + ], + "children": [], + "area": 2708646.115664, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 156459, + "strid": "305f6ab4-8a6c-4efc-bb27-c57fcf642c5c", + "image_id": 206611, + "image_name": "23998.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 83.91, + 1828.582, + 235.84099999999998, + 59.89599999999996 + ], + "priority": 6, + "parents": [ + 156479 + ], + "children": [ + 156456 + ], + "area": 153436.31562, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 156456, + "strid": "5431ed24-2ec5-4bb7-ba9a-972ecdf0485b", + "image_id": 206611, + "image_name": "23998.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 73.254, + 1899.412, + 3221.968, + 328.1629999999998 + ], + "priority": 7, + "parents": [ + 156459 + ], + "children": [], + "area": 139139.526648, + "iscrowd": 0, + "segmentation": [], + "text": "Participants were recruited purposively and the sample was stratified by treatment-taking pattern (those who adhere well, partially adhere, and LTFU within the last 6\nmonths), and by patient characteristics such as gender and age. 52 in-depth interviews were conducted with MDR-TB patients (n=35) and health practitioners (n=12),\nincluding 5 follow-up interviews to probe emerging themes. Data was analysed using open coding, drawing on the principles of grounded theory, with constant\ncomparison of codes within and between cases to raise codes to a conceptual level and to generate theory from participant accounts. Discrepancies from majority\nthemes were actively investigated. Ethical approval was granted from the Uzbekistan Ethics Committee and MSF Ethics Review Board." + }, + { + "id": 156460, + "strid": "46adc1ee-500f-4143-9516-179e378f50de", + "image_id": 206611, + "image_name": "23998.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 83.91, + 2323.662, + 204.02200000000002, + 64.57600000000002 + ], + "priority": 8, + "parents": [ + 156479 + ], + "children": [ + 156465, + 156466, + 156475, + 156467, + 156472, + 156462, + 156474, + 156461, + 156473, + 156476, + 156468, + 156469, + 156470, + 156471 + ], + "area": 194978.47841999997, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 156465, + "strid": "6181fb43-52b3-47e3-b281-7ffb1ad3d41d", + "image_id": 206611, + "image_name": "23998.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 78.076, + 2417.302, + 2097.766, + 419.9380000000001 + ], + "priority": 9, + "parents": [ + 156460 + ], + "children": [], + "area": 188733.270952, + "iscrowd": 0, + "segmentation": [], + "text": "Three main themes emerged: hope and better knowledge offering the potential to overcome non-\nadherence; patient autonomy and control optimising engagement with treatment; and perceptions of the\nbody, self, treatment and disease on tolerance.\n\nThe first theme shows that patients had limited TB knowledge, and understanding the disease can improve\npatient acceptance. Belief in treatment efficacy and its impact on cure was said to be the most important\n\nfactor motivating adherence, and distrust in medical advice lowers motivation ~~~" + }, + { + "id": 156466, + "strid": "90238436-d46c-4394-b96a-e2d693e8f1f5", + "image_id": 206611, + "image_name": "23998.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 72.298, + 2875.767, + 826.393, + 50.08399999999983 + ], + "priority": 10, + "parents": [ + 156460 + ], + "children": [], + "area": 207912.202566, + "iscrowd": 0, + "segmentation": [], + "text": "“If they don’t have information, they" + }, + { + "id": 156467, + "strid": "64639961-a331-49f2-b58f-4471e8735b4f", + "image_id": 206611, + "image_name": "23998.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 239.888, + 2935.303, + 490.005, + 117.68499999999995 + ], + "priority": 11, + "parents": [ + 156460 + ], + "children": [], + "area": 704143.966064, + "iscrowd": 0, + "segmentation": [], + "text": "won't take treatment”\nHCW 07" + }, + { + "id": 156468, + "strid": "be959614-d392-4ee0-81ee-86f674d264c4", + "image_id": 206611, + "image_name": "23998.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 788.89, + 2937.409, + 834.0979999999998, + 235.01099999999997 + ], + "priority": 12, + "parents": [ + 156460 + ], + "children": [], + "area": 2317292.58601, + "iscrowd": 0, + "segmentation": [], + "text": "“The idea that they were telling me a\nlie was inside of me like a worm... |\nwas like eating myself from inside\nnot believing it’” P01" + }, + { + "id": 156469, + "strid": "749c600b-e3fd-4faa-a0e4-aa02df2b004e", + "image_id": 206611, + "image_name": "23998.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1457.324, + 2843.019, + 732.0030000000002, + 59.715999999999894 + ], + "priority": 13, + "parents": [ + 156460 + ], + "children": [], + "area": 4143199.821156, + "iscrowd": 0, + "segmentation": [], + "text": "“If you believe in it then you will" + }, + { + "id": 156470, + "strid": "ca992298-948a-400d-bf83-77292dfd65d7", + "image_id": 206611, + "image_name": "23998.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1649.956, + 2910.44, + 329.40100000000007, + 48.1579999999999 + ], + "priority": 14, + "parents": [ + 156460 + ], + "children": [], + "area": 4802097.94064, + "iscrowd": 0, + "segmentation": [], + "text": "be cured” P21" + }, + { + "id": 156471, + "strid": "0bad275b-a07b-4510-b453-d479325a79ba", + "image_id": 206611, + "image_name": "23998.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 73.053, + 3205.016, + 2104.088, + 464.1080000000002 + ], + "priority": 15, + "parents": [ + 156460 + ], + "children": [], + "area": 234136.033848, + "iscrowd": 0, + "segmentation": [], + "text": "The second theme reveals that the social sacrifices that treatment requires causes some patients to feel\nunable to prioritise it over other areas of life. The societal role of daughter-in-law prevented some female\npatients from feeling able to continue with treatment, as could males’ role as breadwinner. Certain female\nparticipants recommended women who are daughters-in-law have the option to receive treatment at hospital.\nPatients’ authority over treatment-taking was also influenced by hierarchical practitioner-patient relationships\nwhich could undermine their engagement and control. A strong character and aspirations post-treatment\nwere seen to help with ownership of treatment-taking and drove patients to overcome challenges." + }, + { + "id": 156472, + "strid": "7ada9f31-eec3-4f16-ae93-240088ac280c", + "image_id": 206611, + "image_name": "23998.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 127.654, + 3719.826, + 770.264, + 393.90700000000015 + ], + "priority": 16, + "parents": [ + 156460 + ], + "children": [], + "area": 474850.668204, + "iscrowd": 0, + "segmentation": [], + "text": "“My husband’s house were\nagainst... wouldn’t let me take\ntreatment... | took the drugs for\nabout six months and then left,\n\nbeing a defaulter... What they say\nis: “we need someone who will\nserve us...” P03" + }, + { + "id": 156473, + "strid": "37de569a-b01e-409b-9524-1ce5177fe5e6", + "image_id": 206611, + "image_name": "23998.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1282.075, + 3723.726, + 758.5640000000001, + 296.4050000000002 + ], + "priority": 17, + "parents": [ + 156460 + ], + "children": [], + "area": 4774096.01145, + "iscrowd": 0, + "segmentation": [], + "text": "“Due to my family reasons |\ncouldn't... | had to stop the\ntreatment. Because there was no\nother source of income.” P32\n\n(LTFU)" + }, + { + "id": 156476, + "strid": "50ea6560-4c36-4d09-a946-7776be546b01", + "image_id": 206611, + "image_name": "23998.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 71.103, + 4137.133, + 2115.789, + 200.85400000000027 + ], + "priority": 18, + "parents": [ + 156460 + ], + "children": [], + "area": 294162.56769899995, + "iscrowd": 0, + "segmentation": [], + "text": "The third theme describes how the side effect burden from treatment affects adherence and how the mood\nand mind set of the patient can influence treatment tolerance, with focusing on positives, distractions from\ntreatment and visualisation techniques seen to ease drug side effects." + }, + { + "id": 156474, + "strid": "ac5f6197-3312-4d05-8580-f4c630b4f2c2", + "image_id": 206611, + "image_name": "23998.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 119.854, + 4361.387, + 824.865, + 304.2049999999999 + ], + "priority": 19, + "parents": [ + 156460 + ], + "children": [], + "area": 522729.677498, + "iscrowd": 0, + "segmentation": [], + "text": "“If you lose liver then you will die\nsoon. If you lose lung you will live a\nbit longer... | said | wouldn’t take\nthem anymore. | will spoil my liver,\nmy liver will be destroyed.” P27" + }, + { + "id": 156475, + "strid": "18d4d357-2681-4e72-9192-0b60017ab572", + "image_id": 206611, + "image_name": "23998.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1272.325, + 4361.387, + 859.9660000000001, + 351.0060000000003 + ], + "priority": 20, + "parents": [ + 156460 + ], + "children": [], + "area": 5549101.714775, + "iscrowd": 0, + "segmentation": [], + "text": "“If you suffer and you think of\nsomething bad you will not be able to\ntake the drugs, it’ll be even worse.\nAnd if you are joyful and don’t think\nof anything bad then the drugs will\nnot... [affect] you much.” P11" + }, + { + "id": 156461, + "strid": "ba12e905-e893-4cb5-aa64-34006c6328c6", + "image_id": 206611, + "image_name": "23998.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2261.284, + 2276.66, + 1068.4609999999998, + 582.3240000000001 + ], + "priority": 21, + "parents": [ + 156460 + ], + "children": [], + "area": 5148174.83144, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 156462, + "strid": "48939e9f-ca9a-41ba-b3b8-dbc250ce5de6", + "image_id": 206611, + "image_name": "23998.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2263.883, + 2913.577, + 1050.2640000000001, + 509.5340000000001 + ], + "priority": 22, + "parents": [ + 156460 + ], + "children": [], + "area": 6595997.439491, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 156464, + "strid": "bc7bab0c-d3e8-4c17-a129-97b44ad3305c", + "image_id": 206611, + "image_name": "23998.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2300.279, + 3540.096, + 306.75999999999976, + 67.5909999999999 + ], + "priority": 23, + "parents": [ + 156479 + ], + "children": [ + 156463 + ], + "area": 8143208.486784, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion" + }, + { + "id": 156463, + "strid": "d16e1ce9-e816-4201-b856-c4a644da8b0e", + "image_id": 206611, + "image_name": "23998.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2302.878, + 3615.486, + 990.471, + 595.3230000000003 + ], + "priority": 24, + "parents": [ + 156464 + ], + "children": [], + "area": 8326023.168708, + "iscrowd": 0, + "segmentation": [], + "text": "Disease knowledge and_. belief, patient\nautonomy and control, and views on TB drugs\ninfluence adherence to MDR-TB treatment in\nthis context. Patient knowledge and understanding\nabout MDR-TB and treatment should be enhanced\nand practitioner-patient relationships should move\ntowards more patient-centred models of care,\nwhere patients have ownership and responsibility\nfor their treatment-taking." + }, + { + "id": 156478, + "strid": "b59bd43c-4c5e-4d21-b674-5236162eddbf", + "image_id": 206611, + "image_name": "23998.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2304.487, + 4352.075, + 530.6219999999998, + 66.32800000000043 + ], + "priority": 25, + "parents": [ + 156479 + ], + "children": [ + 156477 + ], + "area": 10029300.260525, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements" + }, + { + "id": 156477, + "strid": "034b5ab5-3385-4e16-bbb4-c3a49586c9e7", + "image_id": 206611, + "image_name": "23998.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2291.458, + 4442.091, + 998.469, + 265.3109999999997 + ], + "priority": 26, + "parents": [ + 156478 + ], + "children": [], + "area": 10178864.958678002, + "iscrowd": 0, + "segmentation": [], + "text": "Thank you to the patients and staff involved in the\nMSF/MoH_ Karakalpakstan project. Thanks to\nAhmet Amangeldiev for data collection and\ninterpretation assistance." + }, + { + "id": 8934, + "strid": "9504232c-3e06-4c25-8c2d-7b7ffcde047a", + "image_id": 200857, + "image_name": "11157.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 19.72, + 37.29, + 183.04, + 211.20000000000002 + ], + "priority": -1, + "parents": [], + "children": [ + 8939, + 8927, + 8928, + 8946, + 8947, + 8935, + 8940, + 8944, + 8926 + ], + "area": 735.3588, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 8926, + "strid": "89cc0af7-ceb0-4e6f-a469-87e2266a0957", + "image_id": 200857, + "image_name": "11157.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 209.153, + 161.422, + 2507.751, + 105.43199999999999 + ], + "priority": 1, + "parents": [ + 8934 + ], + "children": [], + "area": 33761.895566, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 8927, + "strid": "97ad0887-5a26-480c-8ba6-67b0f40bee3c", + "image_id": 200857, + "image_name": "11157.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 81.014, + 298.866, + 2761.155, + 232.93499999999995 + ], + "priority": 2, + "parents": [ + 8934 + ], + "children": [], + "area": 24212.330123999996, + "iscrowd": 0, + "segmentation": [], + "text": "Stefan Panaiotov', Georgi Filevski?, Michele Equestre’, Elena Nikolova’, Victoria Levterova', lvan Simeonovski',\n\nElizabeta Bachiyska', Maria Nikolova', Reni Kalfin®\n‘National Center of Infectious and Parasitic Diseases, Janko Sakasov 26, Sofia 1504, Bulgaria, ?First Town’s Hospital, Patriarch Eftimii 37, Sofia 1000, Bulgaria, “Istituto\nSuperiore di Sanita, Viale Regina Elena 299, Rome 00161, Italy, 4Institute of Experimental Morphology, Pathology and Anthropology, Bulgarian Academy of Sciences, Acad. G.\nBonchev Str. 25, Sofia 1113, Bulgaria, ‘Institute of Neurobiology, Bulgarian Academy of Sciences, Acad. G. Bonchev Str. 23, Sofia 1113, Bulgaria" + }, + { + "id": 8928, + "strid": "564aa00b-2330-4f5b-bedf-e4b620a35160", + "image_id": 200857, + "image_name": "11157.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 284.85, + 693.478, + 427.298, + 73.17399999999998 + ], + "priority": 3, + "parents": [ + 8934 + ], + "children": [ + 8929 + ], + "area": 197537.2083, + "iscrowd": 0, + "segmentation": [], + "text": "Background" + }, + { + "id": 8929, + "strid": "e6b6d922-e132-46e4-8f71-2754682a1d33", + "image_id": 200857, + "image_name": "11157.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 95.053, + 824.842, + 834.813, + 1040.641 + ], + "priority": 4, + "parents": [ + 8928 + ], + "children": [], + "area": 78403.706626, + "iscrowd": 0, + "segmentation": [], + "text": "Current assays for determining the presence of M.\ntuberculosis infection, such as an interferon gamma\nrelease assay (IGRA) or tuberculin skin test (TST),\ncannot predict which infected individuals will develop\nactive tuberculosis.\n\nDormant latent bacteria remain undetected by\nconventional culture methods. Therefore, these\n“invisible” bacteria represent a diagnostic target, which\nif successfully detected may improve tuberculosis\ncontrol hindered by LTBI.\n\nIn 1993 Emil Kalfin cultured blood of healthy individuals\nin BHI broth supplemented with vitamin K and 100% of\nblood cultures were positive for organisms which he\nnamed Chlamydia-Like Microorganisms.\n\nDomingue, G. (1987), Nikkari, S. (2001), McLaughlin, R.\n(2002), Moriyama (2008), Damgaard, C. (2015), Paise,\nS. (2016) also questioned the existence of a blood\nmicrobiome in healthy individuals. Zak, D. (2016)\nattempted to demonstrate that host blood RNA\nsignatures can predict progression to active TB in\nlatently infected individuals.\n\nMarkova, N. (2015, 2017) showed that mycobacterial L-\nforms persist in the blood of BCG vaccinated people\nand suggest that reproductive filterable L-bodies of\nBCG origin are able to pass in the blood circulation of\nthe fetus by vertical transmission." + }, + { + "id": 8940, + "strid": "f89013d4-479d-4a35-8abd-9c31589d39ad", + "image_id": 200857, + "image_name": "11157.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 301.82, + 1934.725, + 316.474, + 62.71100000000001 + ], + "priority": 5, + "parents": [ + 8934 + ], + "children": [ + 8936 + ], + "area": 583938.6995, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 8936, + "strid": "35bc8340-6941-488f-8a43-a2f5ee5d8f13", + "image_id": 200857, + "image_name": "11157.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 100.585, + 2053.946, + 833.677, + 203.66100000000006 + ], + "priority": 6, + "parents": [ + 8940 + ], + "children": [], + "area": 206596.15840999997, + "iscrowd": 0, + "segmentation": [], + "text": "To test resuscitation of dormant blood microbiota and M.\ntuberculosis in blood samples by culturing,\nmicroscopy analysis, physico-chemical analysis,\nDNA isolation and sequencing analysis in healthy\nindividuals and with latent TB infection." + }, + { + "id": 8944, + "strid": "f440ca52-95f1-456e-80b1-099ab2c404c6", + "image_id": 200857, + "image_name": "11157.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 148.525, + 2346.857, + 719.534, + 59.13200000000006 + ], + "priority": 7, + "parents": [ + 8934 + ], + "children": [ + 8930, + 8931 + ], + "area": 348566.935925, + "iscrowd": 0, + "segmentation": [], + "text": "Materials\n\n& Methods" + }, + { + "id": 8930, + "strid": "769cb09c-1cb7-4aab-b0b8-e12a97b4ced3", + "image_id": 200857, + "image_name": "11157.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 99.105, + 2476.181, + 867.825, + 280.9920000000002 + ], + "priority": 8, + "parents": [ + 8944 + ], + "children": [], + "area": 245401.918005, + "iscrowd": 0, + "segmentation": [], + "text": "Blood was collected from healthy and IGRA(+) volunteers\nusing BD Vacutainer K3E 5 ml tubes. For culturing we\nused Brain Hearth Infusion (BHI) broth (Difco, BD)\nsupplemented with vitamin K 1 mg/ml, 10% (D+) sucrose,\n0.25% sodium citrate and 0.2% yeastolate (Difco, BD).\nGrowth at 43°C was detected at 24 h, but 72 h was\noptimal growing time (Figure 1)." + }, + { + "id": 8931, + "strid": "4b1607e1-2671-4497-90e9-25619fce3000", + "image_id": 200857, + "image_name": "11157.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 97.193, + 2757.912, + 869.768, + 796.3600000000001 + ], + "priority": 9, + "parents": [ + 8944 + ], + "children": [], + "area": 268049.741016, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 8935, + "strid": "92a9c2cd-ae69-412e-a862-a09e64b85653", + "image_id": 200857, + "image_name": "11157.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1277.863, + 698.439, + 259.8589999999999, + 57.313999999999965 + ], + "priority": 10, + "parents": [ + 8934 + ], + "children": [ + 8932, + 8943, + 8933, + 8938 + ], + "area": 892509.355857, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 8943, + "strid": "2b92e33b-f173-4314-8d39-45c7202ce074", + "image_id": 200857, + "image_name": "11157.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1054.371, + 873.46, + 716.5439999999999, + 520.4380000000001 + ], + "priority": 11, + "parents": [ + 8935 + ], + "children": [ + 8945 + ], + "area": 920950.8936600002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 8945, + "strid": "1951b870-1b81-4476-a850-26f30e51fa8b", + "image_id": 200857, + "image_name": "11157.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1010.044, + 1404.215, + 833.7890000000001, + 399.365 + ], + "priority": 12, + "parents": [ + 8943 + ], + "children": [], + "area": 1418318.9354599998, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1 | Microscopic examinations of blood\nmicrobiome (liquid culture). a, Gram stained blood\nmicrobiota of cultured human blood at 43 °C for 48 h, 10\nx 100. Several morphological forms could be observed.\nb, ‘dense body’ of Gram positively stained microbial\ncore structure surrounded by Gram negative coat. c,\nThe ‘dense body’ could divide by simple budding, and/or\nd, produce in chains Gram negatively stained ‘primary\ncells’. Green bar 10um. e, f, TEM division by budding\nand chain forming. g, TEM of ‘primary cell’." + }, + { + "id": 8938, + "strid": "50c87901-217d-4109-b3e7-4b7571f215a7", + "image_id": 200857, + "image_name": "11157.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1082.19, + 1821.966, + 696.4969999999998, + 528.1390000000001 + ], + "priority": 13, + "parents": [ + 8935 + ], + "children": [ + 8941 + ], + "area": 1971713.38554, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 8941, + "strid": "1b9fdcc6-2245-4eee-9174-c3853f0f8915", + "image_id": 200857, + "image_name": "11157.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1014.327, + 2379.24, + 831.1789999999999, + 158.10500000000002 + ], + "priority": 14, + "parents": [ + 8938 + ], + "children": [], + "area": 2413327.3714799997, + "iscrowd": 0, + "segmentation": [], + "text": "Figire 2 | Colonies of blood microbiota on agar\nplate. a, Growth on agar plate for 30 days at 43 °C. b,\nZoom in of the sector plate. c, Gram_ stained\npreparation. d, Zoom in sector. Gree bar 10m." + }, + { + "id": 8933, + "strid": "86826d29-c60e-4a99-a928-6e542cdb741a", + "image_id": 200857, + "image_name": "11157.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1149.848, + 2547.296, + 654.4470000000001, + 469.5 + ], + "priority": 15, + "parents": [ + 8935 + ], + "children": [ + 8937 + ], + "area": 2929003.2110079997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 8937, + "strid": "da7df072-586b-4437-8ac3-108ce2f6392e", + "image_id": 200857, + "image_name": "11157.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1033.592, + 3052.147, + 866.923, + 442.27800000000025 + ], + "priority": 16, + "parents": [ + 8933 + ], + "children": [], + "area": 3154674.7220240002, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3 | Physico-chemical properties of the blood\nmicrobiota. a, Gram stained blood microbiota grown on\nagar for 30 days at 43 °C. b, c, Disintegration of the\nsample with ultrasound (MSE, UK) for 1 h. Cells with\nstreptococcal appearance of 0.1-0.2 pm dominate. d,\nUncultured blood sample after gamma irradiation with\n25+25 KGy dose. e, 25+25 KGy irradiated sample\ncultured for 14 days at 43 °C. f, Sector zoom in. g, h, i,\nBlood microbiota treated with 10% KOH, (h) with 10%\nNaOH - Gram negatively stained microbial structures are\nnot seen and (i) with 10% CH,COOH for 30 min at 37 °C" + }, + { + "id": 8932, + "strid": "b26ea7c7-ae10-4389-a94e-89892f975b12", + "image_id": 200857, + "image_name": "11157.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1900.044, + 843.418, + 1028.7660000000003, + 1444.121 + ], + "priority": 17, + "parents": [ + 8935 + ], + "children": [ + 8948 + ], + "area": 1602531.310392, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 8948, + "strid": "5ced485d-2590-49aa-b28d-e3f741c05110", + "image_id": 200857, + "image_name": "11157.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1907.939, + 665.732, + 957.8509999999999, + 158.76700000000005 + ], + "priority": 18, + "parents": [ + 8932 + ], + "children": [], + "area": 1270176.046348, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1. 16S rDNA genes and ITS2 region targeted\nmetagenomic sequencing data. Confirmed bacterial and fungi\n\nphyla and genera in the blood of two healthy individuals of blood\ngroup A and B." + }, + { + "id": 8947, + "strid": "098b35dd-bb5d-490a-bba4-64c41d58ddea", + "image_id": 200857, + "image_name": "11157.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2148.176, + 2366.53, + 490.2040000000002, + 65.91899999999987 + ], + "priority": 19, + "parents": [ + 8934 + ], + "children": [ + 8942 + ], + "area": 5083722.94928, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 8942, + "strid": "c745fe9b-ec39-4173-b70d-2aff4b6c5c2b", + "image_id": 200857, + "image_name": "11157.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1958.702, + 2504.826, + 911.3199999999999, + 697.3450000000003 + ], + "priority": 20, + "parents": [ + 8947 + ], + "children": [], + "area": 4906207.695852, + "iscrowd": 0, + "segmentation": [], + "text": "The dormant blood microbiota are innate of the\nhealthy humans. On the bases of the 16S rRNA\ngenes and ITS2 sequencing results we identified\nOTUs similarity with 25 bacterial genera belonging\nto 4 phyla and 10 fungi genera (predominantly\nAlternaria, Epicoccum, Monographella, Malassezia,\nFilobasidium and others) belonging to 2 phyla. For\nthe first time we confirm presence of fungi in the\nblood of healthy individuals. Resuscitation of the\nLTBI blood microbiome is_ highly challenging.\nPreliminary results suggest that using vitamin K to\nreanimate the dormant bacteria may enable\nquantitative detection of the dormant M. tuberculosis\npopulation in patients with LTBI and holds promise\nfor becoming a predictive tool for LTBI dynamics." + }, + { + "id": 8939, + "strid": "75561b1b-53ce-4e08-90ab-c695fd319b8a", + "image_id": 200857, + "image_name": "11157.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1978.416, + 3257.102, + 930.5739999999998, + 366.59000000000015 + ], + "priority": 21, + "parents": [ + 8934 + ], + "children": [], + "area": 6443902.7104319995, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 8946, + "strid": "ea63817d-63ec-4acf-a1fe-bee040c050c7", + "image_id": 200857, + "image_name": "11157.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 984.133, + 3588.182, + 949.374, + 78.33100000000013 + ], + "priority": 22, + "parents": [ + 8934 + ], + "children": [], + "area": 3531248.316206, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements: This project has received funding from\nthe National Science Fund of Bulgaria GA: H-01-4/16.12.2016" + }, + { + "id": 98522, + "strid": "86ad4bfe-c928-43aa-b4b5-6b2595c3b0e6", + "image_id": 204313, + "image_name": "121854.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 3097.52, + 16.69, + 167.6199999999999, + 234.66 + ], + "priority": -1, + "parents": [], + "children": [ + 98490, + 98503, + 98518, + 98492, + 98502, + 98491, + 98494, + 98520, + 98510, + 98521, + 98509 + ], + "area": 51697.6088, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 98490, + "strid": "3a046ccf-5583-46e0-b7cb-572faebf4b48", + "image_id": 204313, + "image_name": "121854.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 54.678, + 9.16, + 2534.65, + 239.158 + ], + "priority": 1, + "parents": [ + 98522 + ], + "children": [], + "area": 500.85048, + "iscrowd": 0, + "segmentation": [], + "text": "ResiCon: a method for the identification of dynamic\ndomains, hinges and interfacial regions in proteins." + }, + { + "id": 98491, + "strid": "e3a5de41-4419-4365-af42-7a74db42f308", + "image_id": 204313, + "image_name": "121854.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 52.543, + 276.077, + 2474.86, + 241.293 + ], + "priority": 2, + "parents": [ + 98522 + ], + "children": [], + "area": 14505.913811, + "iscrowd": 0, + "segmentation": [], + "text": "Maciej Dziubinski, Pawet Daniluk* and Bogdan Lesyng\n\nDepartment of Biophysics and CoE BioExploratorium, Faculty of Physics, University of Warsaw, Zwirki i Wigury 93, 02-089 Warsaw, Poland, and\nBioinformatics Laboratory, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawifskiego 5, 02-106 Warsaw, Poland\n\npawel@bioexploratorium.pl" + }, + { + "id": 98492, + "strid": "7dea91a2-b924-4bc2-9378-54a915153773", + "image_id": 204313, + "image_name": "121854.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 71.339, + 572.412, + 325.405, + 62.178999999999974 + ], + "priority": 3, + "parents": [ + 98522 + ], + "children": [ + 98493 + ], + "area": 40835.299668, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 98493, + "strid": "c834a80d-e096-488e-a879-4bd166b61282", + "image_id": 204313, + "image_name": "121854.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 73.198, + 659.358, + 3166.164, + 356.88699999999994 + ], + "priority": 4, + "parents": [ + 98492 + ], + "children": [], + "area": 48263.686883999995, + "iscrowd": 0, + "segmentation": [], + "text": "With current simulation methods and computational power it is possible to acquire Molecular Dynamics (MD) trajectories in microsecond time-scales in which major\nconformational changes can be observed. Because of the large amount of data produced in such simulations, it is necessary to use fast, automatic procedures to track\nand describe structural motions. We propose a new approach called ResiCon which performs a data-mining analysis of MD trajectories, and finds dynamic domains\n(quasi-rigid parts). ResiCon uses a time-generalized concept of a contact between amino-acid residues to construct a virtual scaffold characterizing the rigidness of a\nprotein (see [1] for the description of local structural properties, including contacts). Stiffness of edges reflects variability of corresponding contacts observed during\nsimulation. Next, ResiCon performs a spectral clustering, treating resulting clusters as putative quasi-rigid regions. We propose employing ResiCon to study proteins\nwith flexible structural domains. ResiCon is available as a web server at http: //dworkowa.imdik.pan.p1/EP/ResiCon" + }, + { + "id": 98502, + "strid": "7223ef29-af4d-446b-978e-125176845309", + "image_id": 204313, + "image_name": "121854.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 74.178, + 1082.325, + 715.521, + 69.9380000000001 + ], + "priority": 5, + "parents": [ + 98522 + ], + "children": [ + 98498, + 98499, + 98500, + 98501 + ], + "area": 80284.70385, + "iscrowd": 0, + "segmentation": [], + "text": "Contact between residues" + }, + { + "id": 98499, + "strid": "8b7f1155-6aaa-4ef0-86e6-434ccfa8f91a", + "image_id": 204313, + "image_name": "121854.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 76.391, + 1171.604, + 1498.315, + 203.93700000000013 + ], + "priority": 6, + "parents": [ + 98502 + ], + "children": [], + "area": 89500.00116400002, + "iscrowd": 0, + "segmentation": [], + "text": "We say that two residues are in contact, if for at least one configuration in the\ntrajectory the following condition is satisfied:\n\n(dq <6.5A) V (dco <8A A dy — do > 0.75A)" + }, + { + "id": 98500, + "strid": "177440cf-cc60-4057-85eb-f7678d972e28", + "image_id": 204313, + "image_name": "121854.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 72.229, + 1450.457, + 1502.477, + 233.0709999999999 + ], + "priority": 7, + "parents": [ + 98502 + ], + "children": [], + "area": 104765.058653, + "iscrowd": 0, + "segmentation": [], + "text": "Geometrical variability of a pair of residues i and j is quantified using the fol-\nlowing metric:\n\nGii,j) = max RMSD(E;,\n\nj?\npairs of states (r,s) *d\n\nE;;)" + }, + { + "id": 98501, + "strid": "7efef4be-0a3d-4c4d-b2b2-caa19958a7d4", + "image_id": 204313, + "image_name": "121854.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 70.148, + 1727.23, + 1506.639, + 156.07500000000005 + ], + "priority": 8, + "parents": [ + 98502 + ], + "children": [], + "area": 121161.73004, + "iscrowd": 0, + "segmentation": [], + "text": "where E7, denotes the conformation of a contact between residues i and j in the\n\nr* trajectory frame. Small values of geometrical variability correspond to strong\ncontacts." + }, + { + "id": 98498, + "strid": "29ba35c5-e73c-4824-b63b-8ac83863a866", + "image_id": 204313, + "image_name": "121854.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1622.569, + 1209.062, + 524.4099999999999, + 667.999 + ], + "priority": 9, + "parents": [ + 98502 + ], + "children": [], + "area": 1961786.5202779998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 98494, + "strid": "8f99bf06-4ec0-4a84-8d52-a80410b6ff82", + "image_id": 204313, + "image_name": "121854.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2229.636, + 1090.221, + 484.7339999999999, + 64.75900000000001 + ], + "priority": 10, + "parents": [ + 98522 + ], + "children": [ + 98495, + 98497, + 98496 + ], + "area": 2430795.989556, + "iscrowd": 0, + "segmentation": [], + "text": "Similarity function" + }, + { + "id": 98495, + "strid": "944a2d0b-72f7-4399-8558-ba963845634a", + "image_id": 204313, + "image_name": "121854.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2229.039, + 1171.806, + 487.1550000000002, + 413.241 + ], + "priority": 11, + "parents": [ + 98494 + ], + "children": [], + "area": 2612001.2744340003, + "iscrowd": 0, + "segmentation": [], + "text": "In order to use the spec-\ntral clustering algorithm\npresented in [2], we need\na normalized measure of\na strength of a contact.\nWe have been using a lo-\ngistic function of the ge-\nometrical variability:" + }, + { + "id": 98496, + "strid": "2aaf0467-728b-425c-8d30-9be88b1748bb", + "image_id": 204313, + "image_name": "121854.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2725.153, + 1169.566, + 510.67300000000023, + 387.4839999999999 + ], + "priority": 12, + "parents": [ + 98494 + ], + "children": [], + "area": 3187246.293598, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 98497, + "strid": "25f8042b-7375-414a-ba51-8d4ace13a2ae", + "image_id": 204313, + "image_name": "121854.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2234.746, + 1607.062, + 1009.4299999999998, + 270.45900000000006 + ], + "priority": 13, + "parents": [ + 98494 + ], + "children": [], + "area": 3591375.3762519998, + "iscrowd": 0, + "segmentation": [], + "text": "D(i, j) = Laa(G9)),\n\nwith the range (0, 1], which allows for a customisation\nof ResiCon, using parameters a and £3.\nThis leads to the similarity matrix, [D];; := D(i,j)." + }, + { + "id": 98503, + "strid": "e638a693-2e7e-4eb5-9a3d-271925bb636f", + "image_id": 204313, + "image_name": "121854.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 70.82, + 1951.528, + 381.855, + 66.37999999999988 + ], + "priority": 14, + "parents": [ + 98522 + ], + "children": [ + 98504, + 98505 + ], + "area": 138207.21295999998, + "iscrowd": 0, + "segmentation": [], + "text": "The algorithm" + }, + { + "id": 98504, + "strid": "3fee89cc-9175-40b1-b52f-4c0c13312509", + "image_id": 204313, + "image_name": "121854.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 94.13, + 2055.711, + 3102.413, + 437.7930000000001 + ], + "priority": 15, + "parents": [ + 98503 + ], + "children": [], + "area": 193504.07642999996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 98505, + "strid": "addf0d3c-041e-4591-94d2-3cf722746cc0", + "image_id": 204313, + "image_name": "121854.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 71.435, + 2528.53, + 3177.599, + 313.1640000000002 + ], + "priority": 16, + "parents": [ + 98503 + ], + "children": [], + "area": 180625.54055000003, + "iscrowd": 0, + "segmentation": [], + "text": "As INPUT ResiCon requires a sample of representative structures of a protein in the PDB format. For each pair of residues in contact the geometrical variability is\ncalculated. From this, values of parameters a and ( are estimated, and the similarity matrix is constructed. ResiCon carries out a spectral clusterings into 2,3,...,10\nclusters. For each such partitioning an indicator ymin is calculated, which is used to choose the optimal number of clusters, k (see [2]). OUTPUT of ResiCon contains\ninformation on partitioning of the studied protein molecule into quasi-rigid structural parts, which correspond to clusters. Result of a clustering procedure is typically\nshown as a colorful stripe. This, along with a coloring of the protein structure, provides a clear visualization of the dynamic domains. In the case of the HIV-1 protease,\nflaps and two larger subdomains emerge when a partitioning into k = 4 clusters is carried out." + }, + { + "id": 98509, + "strid": "9fbbc245-5227-4fa8-b9ad-5432f0707ac6", + "image_id": 204313, + "image_name": "121854.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 74.023, + 2915.827, + 646.389, + 67.34700000000021 + ], + "priority": 17, + "parents": [ + 98522 + ], + "children": [ + 98508, + 98507, + 98506 + ], + "area": 215838.262021, + "iscrowd": 0, + "segmentation": [], + "text": "Sequential discontinuity" + }, + { + "id": 98506, + "strid": "aa186ab0-e465-4d65-9374-4e5e1d5a9b95", + "image_id": 204313, + "image_name": "121854.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 68.463, + 2997.162, + 333.876, + 615.114 + ], + "priority": 18, + "parents": [ + 98509 + ], + "children": [], + "area": 205194.70200599998, + "iscrowd": 0, + "segmentation": [], + "text": "According to\nResiCon, ASN-\n83 (magenta)\nbelongs to a\ndifferent cluster\n(cyan), than\nits sequential\nneighbours (yel-\nlow). This can be\nexplained by the\nfact that ASN-83\nplugs a cavity in" + }, + { + "id": 98508, + "strid": "858b18a7-9fb9-43a7-8089-1b4392f5f4eb", + "image_id": 204313, + "image_name": "121854.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 418.92, + 2999.056, + 642.336, + 589.0459999999998 + ], + "priority": 19, + "parents": [ + 98509 + ], + "children": [], + "area": 1256364.53952, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 98507, + "strid": "0d93874d-78ea-40e8-b42e-ceaf2331b40c", + "image_id": 204313, + "image_name": "121854.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 75.578, + 3616.714, + 1004.2760000000001, + 104.43299999999999 + ], + "priority": 20, + "parents": [ + 98509 + ], + "children": [], + "area": 273344.010692, + "iscrowd": 0, + "segmentation": [], + "text": "the cyan domain, and it remains there throughout\nthe trajectory." + }, + { + "id": 98510, + "strid": "3e3b3ff9-4b65-4ea9-aeba-15264f1e141c", + "image_id": 204313, + "image_name": "121854.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1150.208, + 2908.147, + 596.7069999999999, + 70.34400000000005 + ], + "priority": 21, + "parents": [ + 98522 + ], + "children": [ + 98512, + 98511 + ], + "area": 3344973.9445760003, + "iscrowd": 0, + "segmentation": [], + "text": "HIV-1 clustered into 6" + }, + { + "id": 98511, + "strid": "c36eb3f1-f4dc-4e03-bac6-01bae884a8dd", + "image_id": 204313, + "image_name": "121854.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1151.736, + 2999.502, + 1435.3969999999997, + 373.201 + ], + "priority": 22, + "parents": [ + 98510 + ], + "children": [], + "area": 3454634.4354720004, + "iscrowd": 0, + "segmentation": [], + "text": "The optimal number of clusters (according to ResiCon) is 4. It should be\nnoted, however, that the indicator suggests another interesting partitioning\nfor k = 6 (right). It distinguishes structures resembling “arms” connecting\nflaps with core subdomains.\n\nNote that there is a sequential discontinuity in the cyan/yellow regions.\nSingular residues were assigned to different parts than their sequential\nneighbours." + }, + { + "id": 98512, + "strid": "ce494ccd-ecbe-4bca-b6c9-0433319a76be", + "image_id": 204313, + "image_name": "121854.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2617.191, + 3012.325, + 613.7780000000002, + 339.31500000000005 + ], + "priority": 23, + "parents": [ + 98510 + ], + "children": [], + "area": 7883829.879074999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 98521, + "strid": "b0ac3377-d73d-490e-8c0c-330cb9db4836", + "image_id": 204313, + "image_name": "121854.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1150.478, + 3445.431, + 317.55899999999997, + 59.233999999999924 + ], + "priority": 24, + "parents": [ + 98522 + ], + "children": [ + 98513, + 98516, + 98515, + 98514 + ], + "area": 3963892.5660180002, + "iscrowd": 0, + "segmentation": [], + "text": "Web server" + }, + { + "id": 98515, + "strid": "d5efae00-0c53-4d6b-94dd-7b43fa218422", + "image_id": 204313, + "image_name": "121854.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1153.624, + 3525.575, + 517.5820000000001, + 652.6580000000004 + ], + "priority": 25, + "parents": [ + 98521 + ], + "children": [], + "area": 4067187.9337999998, + "iscrowd": 0, + "segmentation": [], + "text": "Here we show a run for\nthe 1cfc_ protein. A\npartitioning into two dy-\nnamic domains is the most\nfavorable (has the low-\nest geometrical variabil-\nity). But also, a par-\ntitioning into three clus-\nters reveals a quasi-rigid\nloop in the red dynamic\ndomain. We would be\npleased if you decided to\ntest ResiCon for yourself at" + }, + { + "id": 98514, + "strid": "d951f831-0cca-48c7-94bd-f4e6e931014f", + "image_id": 204313, + "image_name": "121854.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1691.806, + 3533.056, + 728.7640000000001, + 580.8200000000002 + ], + "priority": 26, + "parents": [ + 98521 + ], + "children": [], + "area": 5977245.339136, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 98516, + "strid": "ca4e0f1e-8be2-4e5f-8580-584680403ebc", + "image_id": 204313, + "image_name": "121854.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1151.108, + 4263.011, + 1269.392, + 320.1270000000004 + ], + "priority": 27, + "parents": [ + 98521 + ], + "children": [], + "area": 4907186.066188, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 98513, + "strid": "fb5c7864-7d8f-400b-b874-43232824eb8b", + "image_id": 204313, + "image_name": "121854.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2474.037, + 3531.329, + 728.8299999999999, + 1062.377 + ], + "priority": 28, + "parents": [ + 98521 + ], + "children": [], + "area": 8736638.605173, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 98518, + "strid": "5b4ac644-2747-422d-86a6-06463bda662d", + "image_id": 204313, + "image_name": "121854.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 73.318, + 4281.62, + 539.572, + 67.44599999999991 + ], + "priority": 29, + "parents": [ + 98522 + ], + "children": [ + 98517 + ], + "area": 313919.81516, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements" + }, + { + "id": 98517, + "strid": "543ff9c8-4d9c-4828-89e1-9696fce843ce", + "image_id": 204313, + "image_name": "121854.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 68.339, + 4355.943, + 1016.193, + 252.2539999999999 + ], + "priority": 30, + "parents": [ + 98518 + ], + "children": [], + "area": 297680.78867700003, + "iscrowd": 0, + "segmentation": [], + "text": "These studies were supported by the Biocentrum-\nOchota project (POIG.02.03.00-00-003/09), the re-\nsearch grant (DEC-2011/03/D/NZ2/02004) of the\nNational Science Centre, and the BST 163500/BF (z.\nb. 14)." + }, + { + "id": 98520, + "strid": "b48dea39-1acf-43d8-8d78-9376b3292646", + "image_id": 204313, + "image_name": "121854.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 76.048, + 3800.639, + 309.955, + 55.78200000000015 + ], + "priority": 31, + "parents": [ + 98522 + ], + "children": [ + 98519 + ], + "area": 289030.994672, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 98519, + "strid": "84ad40f7-b65e-42fe-8288-dd3abf350dd9", + "image_id": 204313, + "image_name": "121854.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 72.433, + 3876.776, + 1010.6190000000001, + 334.96399999999994 + ], + "priority": 32, + "parents": [ + 98520 + ], + "children": [], + "area": 280806.516008, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 78163, + "strid": "cfd8dda6-9114-49ee-8c33-982d12bf9519", + "image_id": 203549, + "image_name": "120453.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 390.82, + 38.19, + 261.48999999999995, + 73.75 + ], + "priority": -1, + "parents": [], + "children": [ + 78137, + 78136, + 78147, + 78161, + 78153, + 78144, + 78138, + 78140 + ], + "area": 14925.415799999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 78136, + "strid": "78bf0ae3-885c-41e5-bd21-6658a212ac75", + "image_id": 203549, + "image_name": "120453.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 748.295, + 40.071, + 2090.196, + 81.381 + ], + "priority": 1, + "parents": [ + 78163 + ], + "children": [], + "area": 29984.928944999996, + "iscrowd": 0, + "segmentation": [], + "text": "FusionQuery: A NOVEL TOOL FOR GENE-SPECIFIC FUSION DETEGNON" + }, + { + "id": 78137, + "strid": "8b150267-835f-44c4-9f8c-dcca0df51e07", + "image_id": 203549, + "image_name": "120453.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 297.804, + 149.906, + 2946.966, + 122.48200000000003 + ], + "priority": 2, + "parents": [ + 78163 + ], + "children": [], + "area": 44642.606424, + "iscrowd": 0, + "segmentation": [], + "text": "Gaye\n\nUL Yuxiang Tan’, Bjoern Chapuy~Margaret A Shipp”, Stefano Monti>\n\n‘Bioinformatics Program, Boston University, Boston, MA. ?Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. 3Section of Computational Biomedicine, Department Of Medicine Boston University School of Medicine, Boston, MA." + }, + { + "id": 78138, + "strid": "d111989f-3e48-4265-b64d-ac35b8e283a6", + "image_id": 203549, + "image_name": "120453.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 468.294, + 373.713, + 503.46899999999994, + 69.94400000000002 + ], + "priority": 3, + "parents": [ + 78163 + ], + "children": [ + 78139 + ], + "area": 175007.555622, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 78139, + "strid": "39409883-4898-4599-9a60-c1b26f9f255b", + "image_id": 203549, + "image_name": "120453.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 32.613, + 472.797, + 1364.341, + 611.414 + ], + "priority": 4, + "parents": [ + 78138 + ], + "children": [], + "area": 15419.328561, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 78140, + "strid": "e8c457d2-0665-4da2-ab56-509886c01a96", + "image_id": 203549, + "image_name": "120453.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 156.509, + 1165.374, + 1147.65, + 194.80899999999997 + ], + "priority": 5, + "parents": [ + 78163 + ], + "children": [ + 78141, + 78143 + ], + "area": 182391.519366, + "iscrowd": 0, + "segmentation": [], + "text": "mRNA-seg Data Generation\n& Processing Workflow" + }, + { + "id": 78141, + "strid": "f7593992-2ad7-4e71-a39b-4a9a9cb299ab", + "image_id": 203549, + "image_name": "120453.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 71.694, + 1414.517, + 1192.708, + 609.606 + ], + "priority": 6, + "parents": [ + 78140 + ], + "children": [ + 78142 + ], + "area": 101412.381798, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 78142, + "strid": "ea206bd3-ef01-4552-aa86-7cfbbfd14176", + "image_id": 203549, + "image_name": "120453.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 180.995, + 2073.352, + 1210.4700000000003, + 43.266999999999825 + ], + "priority": 7, + "parents": [ + 78141 + ], + "children": [], + "area": 375266.34524, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. Typical mRNA sequencing data processing workflow." + }, + { + "id": 78143, + "strid": "c00d6392-ed73-4fdd-8295-adc045a2c8e1", + "image_id": 203549, + "image_name": "120453.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 184.48, + 2119.142, + 1214.706, + 168.53600000000006 + ], + "priority": 8, + "parents": [ + 78140 + ], + "children": [], + "area": 390939.31615999993, + "iscrowd": 0, + "segmentation": [], + "text": "The experimental design determines the appropriate library preparation and\nsequencing methods. Next*\\sequence alignment is performed. Its results are the\nrequired input to all the subsequent analysis steps, including expression quantification\n\nand/or structure variation (mutations, fusions, etc.)." + }, + { + "id": 78144, + "strid": "23db6df1-cb18-4516-a94d-0903371fc671", + "image_id": 203549, + "image_name": "120453.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 356.627, + 2389.485, + 866.454, + 86.97600000000011 + ], + "priority": 9, + "parents": [ + 78163 + ], + "children": [ + 78145 + ], + "area": 852154.8670950001, + "iscrowd": 0, + "segmentation": [], + "text": "FusionQuery Workflow" + }, + { + "id": 78145, + "strid": "6db3a756-a887-4ed4-ae16-e9c678ec9b5f", + "image_id": 203549, + "image_name": "120453.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 147.078, + 2504.352, + 1288.12, + 601.857 + ], + "priority": 10, + "parents": [ + 78144 + ], + "children": [ + 78146 + ], + "area": 368335.08345599996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 78146, + "strid": "679a71d4-af3a-490b-9cf8-3b1146d26ec8", + "image_id": 203549, + "image_name": "120453.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 135.985, + 3137.026, + 1275.1679999999997, + 261.5369999999998 + ], + "priority": 11, + "parents": [ + 78145 + ], + "children": [], + "area": 426588.48061, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2. FusionQuery workflow. The input includes alignment results-in BAM\nformat. (Both Aligned’reads and Unmapped reads) Then the system looks\\forfusion\npartners of the query gene by mainly using BLAT and Bowtie2. The systemwilloutput:\n\n1) The listiof fusion partners of the query gene, their breakpoint locationpand number of\nsupportingyeads. 2) The alignment details of these supporting reads in-BAM format.\n\n3) Thevalignment visualization of each fusion pair." + }, + { + "id": 78147, + "strid": "2625f30b-053b-47f2-85d7-73244865bbe4", + "image_id": 203549, + "image_name": "120453.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 369.18, + 3472.252, + 805.98, + 180.13599999999997 + ], + "priority": 12, + "parents": [ + 78163 + ], + "children": [ + 78148, + 78151, + 78149 + ], + "area": 1281885.99336, + "iscrowd": 0, + "segmentation": [], + "text": "Evaluation on\nBreast Cancer Data" + }, + { + "id": 78148, + "strid": "4d2f885c-a404-4e7b-b668-3ced70d1c261", + "image_id": 203549, + "image_name": "120453.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 105.638, + 3693.107, + 1260.646, + 40.19399999999996 + ], + "priority": 13, + "parents": [ + 78147 + ], + "children": [], + "area": 390132.437266, + "iscrowd": 0, + "segmentation": [], + "text": "Breast Cancer data is a well studied dataset for fusion events, and experimentally validated." + }, + { + "id": 78149, + "strid": "6355635a-5e51-4c76-b97d-4961228bc7e0", + "image_id": 203549, + "image_name": "120453.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 103.814, + 3753.57, + 1343.19, + 308.2950000000001 + ], + "priority": 14, + "parents": [ + 78147 + ], + "children": [ + 78150 + ], + "area": 389673.11598, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 78150, + "strid": "4b4ae664-e0cc-4abc-a608-60fde9b62411", + "image_id": 203549, + "image_name": "120453.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 106.25, + 4073.629, + 1361.512, + 172.85099999999966 + ], + "priority": 15, + "parents": [ + 78149 + ], + "children": [], + "area": 432823.08125, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1. Comparison of sensitivity between TophatFusion,(deFuse and\nFusionQuery on three Breast Cancer samples. TophatFusion‘and deFuse, which\nare two most popular unbiased fusion detection algorithms. FusionQueryonly detects fusions\ninvolving'the query gene. Here, one of the partners of a known fusion‘is.used as the query gene." + }, + { + "id": 78151, + "strid": "a9addee2-cf7e-4a16-b2c3-4f4c7a9a0d78", + "image_id": 203549, + "image_name": "120453.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 142.573, + 4269.026, + 1287.612, + 162.82999999999993 + ], + "priority": 16, + "parents": [ + 78147 + ], + "children": [ + 78152 + ], + "area": 608647.843898, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 78152, + "strid": "a11ae9a3-b492-4bb5-9b93-00e4c86df312", + "image_id": 203549, + "image_name": "120453.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 104.997, + 4466.927, + 1345.229, + 172.85099999999966 + ], + "priority": 17, + "parents": [ + 78151 + ], + "children": [], + "area": 469013.934219, + "iscrowd": 0, + "segmentation": [], + "text": "Table 2. Comparison of running time-between TophatFusion, deFuse and\nFusionQuery on a Breast Cancer sample. Although each run of FusionQuery can\nonly detect fusions related to one query, gene, it can significantly save time for biological\nhypothesis testing." + }, + { + "id": 78153, + "strid": "f229570b-814a-4630-8c1f-8d33589a5d8c", + "image_id": 203549, + "image_name": "120453.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1740.651, + 370.161, + 1446.0219999999997, + 93.983 + ], + "priority": 18, + "parents": [ + 78163 + ], + "children": [ + 78155, + 78157, + 78154, + 78159 + ], + "area": 644321.1148110001, + "iscrowd": 0, + "segmentation": [], + "text": "A Case Study on Lymphoma" + }, + { + "id": 78154, + "strid": "15463548-3aca-4c04-bc67-06d2b78eb610", + "image_id": 203549, + "image_name": "120453.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1428.825, + 487.788, + 1867.389, + 97.15700000000004 + ], + "priority": 19, + "parents": [ + 78153 + ], + "children": [], + "area": 696963.6891000001, + "iscrowd": 0, + "segmentation": [], + "text": "A case study: FusionQuery on Geneé1 in an Immuno-Privileged Lymphoma (IPE)sample.\nThe dataset includes 10 Primary Central Nervous System-Lymphoma (PCNSL) samples, and 6 Testicular Lymphoma,(TL) samples." + }, + { + "id": 78155, + "strid": "afc884a8-8cc9-4b52-a271-8958e7bc537d", + "image_id": 203549, + "image_name": "120453.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1473.659, + 587.025, + 1919.4879999999998, + 1934.217 + ], + "priority": 20, + "parents": [ + 78153 + ], + "children": [ + 78156 + ], + "area": 865074.674475, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 78156, + "strid": "7bae007f-9b93-424a-ac76-16a44e8e11c7", + "image_id": 203549, + "image_name": "120453.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1491.532, + 2530.246, + 2020.9349999999997, + 304.58100000000013 + ], + "priority": 21, + "parents": [ + 78155 + ], + "children": [], + "area": 3773942.876872, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3. Fusion hypothesis on Gene’ in SampleA in IPL. Workflow of hypothesis generation. A) Comparison of Copy\nNumber Gains (CNG)<1wo boxed peaks show significant enrichment of CNG in.!RL relative to DLBCL. B) Zoom in of CNG region\nin Gene’. One samplé-shows CNG of only a portion of Gene1 C) ExpressionJével of Gene1 across TL samples. SampleA has\nextremely high expression, suggesting fusion affecting the regulatory region/of Gene1. D) FISH with a split-appart probe athe\nputative fusion-event in control and SampleA. Yellow signal shows there is no fusion in control. In SampleA, seperation of red and\ngreen probes proves the fusion hypothesis on Gene1. E) 5’ RACE PCR result by using a primer on Gene’. Sanger Sequencing\nresult of the RR product shows a fusion with Gene2 and the fusion-breakpoint." + }, + { + "id": 78157, + "strid": "45e186ea-4f25-48f2-b0a5-3a75226d9937", + "image_id": 203549, + "image_name": "120453.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1641.764, + 2886.276, + 1796.615, + 294.29100000000017 + ], + "priority": 22, + "parents": [ + 78153 + ], + "children": [ + 78158 + ], + "area": 4738584.030863999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 78158, + "strid": "f20a421b-911a-4572-8922-1a27b051a38a", + "image_id": 203549, + "image_name": "120453.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1521.816, + 3221.202, + 1980.169, + 136.9459999999999 + ], + "priority": 23, + "parents": [ + 78157 + ], + "children": [], + "area": 4902076.742832, + "iscrowd": 0, + "segmentation": [], + "text": "Table 3 FusionQuery output:Jist of fusion partners. Three different fusion breakpoints‘on Gene2 are detected. The list is ranked\nby number of supporting reads. Fhé-red one is the one found by 5’RACE PCR. Results werescompared with the output of deFuse and\nTophatFusion. Two breakpointsbut.not the red one, were found by deFuse. No Gene'-related fusion were found by TophatFusion." + }, + { + "id": 78159, + "strid": "163091ad-3534-413b-893f-b31e8afa0fc9", + "image_id": 203549, + "image_name": "120453.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1699.476, + 3422.92, + 1589.687, + 607.0050000000001 + ], + "priority": 24, + "parents": [ + 78153 + ], + "children": [ + 78160 + ], + "area": 5817170.389920001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 78160, + "strid": "f399e4a8-1eb2-4478-8298-cb5c89252be3", + "image_id": 203549, + "image_name": "120453.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1521.816, + 4048.431, + 1980.169, + 138.79700000000003 + ], + "priority": 25, + "parents": [ + 78159 + ], + "children": [], + "area": 6160967.070696, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 4. Alignment visualization of Gene2-Gene1 fusion’. Supporting reads of the Gene2-Gene1 fusion at Loc1 are shown.\nThe start codon of Gene’ is maintained? And the regulation region of Gene is replaced by Gene2As a result, the expression of Gene1 can\nbe significantly upregulated by the regulation elements of Gene2." + }, + { + "id": 78161, + "strid": "9f0a5ca8-7803-44fe-bd85-21a35af81abe", + "image_id": 203549, + "image_name": "120453.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2126.515, + 4240.75, + 766.1749999999997, + 71.03600000000006 + ], + "priority": 26, + "parents": [ + 78163 + ], + "children": [ + 78162 + ], + "area": 9018018.48625, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 78162, + "strid": "a79e39f1-ff35-4b72-8ac2-069124931199", + "image_id": 203549, + "image_name": "120453.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1514.785, + 4350.772, + 2002.8680000000002, + 325.7330000000002 + ], + "priority": 27, + "parents": [ + 78161 + ], + "children": [], + "area": 6590484.16402, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86673, + "strid": "4ae09942-2ff7-48f0-a985-96366181e44f", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 74.11, + 53.18, + 103.49, + 192.19 + ], + "priority": -1, + "parents": [], + "children": [ + 86672, + 86643, + 86639, + 86644, + 86641, + 86640, + 86642, + 86638 + ], + "area": 3941.1698, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86638, + "strid": "6c894699-3780-4c59-91a4-0bb80c002c74", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 795.925, + 82.831, + 1775.262, + 160.86599999999999 + ], + "priority": 1, + "parents": [ + 86673 + ], + "children": [], + "area": 65927.263675, + "iscrowd": 0, + "segmentation": [], + "text": "RNA-Seq applications for plant transcriptome analysis 10\nresponse to cold acclimation by lon Torrent technology" + }, + { + "id": 86639, + "strid": "334b4810-2099-40ff-bdb1-3d65760c76f4", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 723.19, + 302.322, + 1893.1770000000001, + 211.02599999999995 + ], + "priority": 2, + "parents": [ + 86673 + ], + "children": [], + "area": 218636.24718, + "iscrowd": 0, + "segmentation": [], + "text": "José Luis Gaete’, Marta Fernandez»2\n\n1 Centro de Biotecnologia, Casilla 160-C, Universidad de Concepcion, Concepcion, Chile,\n2 Facultad de Ciencias Forestales, Casilla 160-C, Universidad de Concepcion, Goncepcion, Ghile:" + }, + { + "id": 86640, + "strid": "eb40dcaf-d0f2-4534-a786-088f35fb4a2e", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1516.699, + 581.189, + 271.905, + 39.791000000000054 + ], + "priority": 3, + "parents": [ + 86673 + ], + "children": [ + 86645 + ], + "area": 881488.7751109999, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 86645, + "strid": "cb569b2e-5be6-4fde-88a9-8e7926029f23", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 101.763, + 655.749, + 3110.613, + 299.192 + ], + "priority": 4, + "parents": [ + 86640 + ], + "children": [], + "area": 66730.98548700001, + "iscrowd": 0, + "segmentation": [], + "text": "RNA-Seq technology has become widely used as a toolto understand the transcriptome of a given experimental system. It uses deep-sequencing technologies to sequence a\ncDNA library to achieve information about the RNA content and transcriptional status of a sample of interest, generating an expression profile, which enables interpreting the\nfunctional elements of the genome, and thus reveal the molecular constituents of cells and tissues< The lon Torrent sequencing technologies simplified sequencing technology\ntranslating directly the chemical information codified into digital data on a semiconductor chip, making it faster, simpler and, more scalable than any other available technology.\nThis study presents a transcriptome analysis.of MRNA libraries from the woody plant Eucalyptus nitens, sequenced on the lon Proton instrument, to identify genes associated to\ncold acclimation. The main objective was toidentify differential expressed (DE) genes involved-in cold acclimation process in £. nitens by RNA-Seq." + }, + { + "id": 86641, + "strid": "337d413d-d257-4711-844f-73e9ed2e00ad", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 712.593, + 1003.614, + 299.3380000000001, + 51.89799999999991 + ], + "priority": 5, + "parents": [ + 86673 + ], + "children": [ + 86649, + 86648, + 86646, + 86651 + ], + "area": 715168.311102, + "iscrowd": 0, + "segmentation": [], + "text": "iviethodology," + }, + { + "id": 86648, + "strid": "a7c5a574-0929-449c-a804-be4380c8cd08", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 96.473, + 1079.056, + 725.156, + 658.4740000000002 + ], + "priority": 6, + "parents": [ + 86641 + ], + "children": [], + "area": 104099.769488, + "iscrowd": 0, + "segmentation": [], + "text": "Twelve expression libraries from leaves\nof 6 months old plants exposed-to four\nacclimation conditions tofake the annual\nseasonal variation in a growth chamber\nwere prepared (Fig.-1)./Three biological\nreplicates to estimate the biological\nvariation for.\\each treatment were\nconsidered. \\“Twelve libraries were\nsequenced\\with lon PI™ chip kit v2\nusing lon PI™ Sequencing 200 kit v2,\nusing.» barcoding for 12 libraries, each\none sequenced on 6 chips. The pipeline\nis shown in Fig. 2." + }, + { + "id": 86646, + "strid": "502db17d-5924-4eb7-9e10-4548a4f9fba9", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 855.304, + 1102.526, + 765.612, + 460.2439999999999 + ], + "priority": 7, + "parents": [ + 86641 + ], + "children": [ + 86647 + ], + "area": 942994.897904, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86647, + "strid": "f02903eb-d777-4b64-8286-b95f00179670", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 865.068, + 1567.19, + 748.2140000000002, + 146.30600000000004 + ], + "priority": 8, + "parents": [ + 86646 + ], + "children": [], + "area": 1355725.91892, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 1 Acclimation and de-acclimation treatments: NA\nnonacclimated, CABF acclimated before frost at -2 C,\nCAAF acclimated after frost at -2 C, DA de-acclimated,\nF -6°G frost at -6 C." + }, + { + "id": 86649, + "strid": "faedefd1-ce8b-4f62-a62e-e42ec45b0547", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 95.981, + 1761.445, + 1513.553, + 483.66599999999994 + ], + "priority": 9, + "parents": [ + 86641 + ], + "children": [ + 86650 + ], + "area": 169065.252545, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86650, + "strid": "98a141fa-b1ef-4876-a0e0-35bec76fe6a7", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 120.402, + 2262.283, + 1461.931, + 72.65099999999984 + ], + "priority": 10, + "parents": [ + 86649 + ], + "children": [], + "area": 272383.397766, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 2 Bioinformatice-pipeline that includes prerprocessing of sequences, reference mapping, counting reads\nmapped to features, differential expression analysis and selection of referencegenes to validate by qRT-PCR." + }, + { + "id": 86651, + "strid": "288ac474-6c1a-4b35-b3b8-05d52d87a58d", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 96.246, + 2349.722, + 1494.32, + 91.64199999999983 + ], + "priority": 11, + "parents": [ + 86641 + ], + "children": [], + "area": 226151.343612, + "iscrowd": 0, + "segmentation": [], + "text": "Genes showing the most stable expression levels (lowestycoefficient of variation)\nwere selected as reference genes for further validation*by-qRT- PCR." + }, + { + "id": 86642, + "strid": "008a1a52-1d8f-4125-b1d9-bb2adad50b2c", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 781.514, + 2497.246, + 159.62900000000002, + 41.18600000000015 + ], + "priority": 12, + "parents": [ + 86673 + ], + "children": [ + 86665, + 86660, + 86658, + 86655, + 86668, + 86652, + 86653, + 86662, + 86657, + 86664 + ], + "area": 1951632.710444, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 86652, + "strid": "f0392ab5-39e2-4627-a2e8-1f4a8ee146cc", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 95.209, + 2570.353, + 1512.213, + 248.16499999999996 + ], + "priority": 13, + "parents": [ + 86642 + ], + "children": [], + "area": 244720.73877700002, + "iscrowd": 0, + "segmentation": [], + "text": "Individual libraries yielded a range of 25 and‘45 millions reads. After preprocessing,\nthis amount decreased from 42% to 99% ‘of total size for each library, depending on\nparameters used (Fig. 3). The best parameters considering quality and size of each\nlibrary were selected. The Fig. .4, shows the million of reads observed after\npreprocessing the library at NA:condition for the first biologial replicate (NA1)." + }, + { + "id": 86653, + "strid": "2cefbbee-b712-498f-829b-1aa530f63da9", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 86.743, + 2843.041, + 1499.743, + 430.3960000000002 + ], + "priority": 14, + "parents": [ + 86642 + ], + "children": [ + 86654 + ], + "area": 246613.905463, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86654, + "strid": "4e07b931-5cc8-44a8-84ae-7c9130e03e54", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 137.149, + 3289.649, + 1443.609, + 71.42099999999982 + ], + "priority": 15, + "parents": [ + 86653 + ], + "children": [], + "area": 451172.070701, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 3.1he blue columns represent the number of input sequences and the rest of columns are the different\nparameters used for the preprocessing ofthe sequences." + }, + { + "id": 86655, + "strid": "7c15a6e4-8493-471b-9045-8242b2b75780", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 74.106, + 3384.935, + 1559.706, + 465.99299999999994 + ], + "priority": 16, + "parents": [ + 86642 + ], + "children": [ + 86656 + ], + "area": 250843.99310999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86656, + "strid": "a7164f91-9703-4e2f-bf87-d443cf95cbeb", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 97.488, + 3852.948, + 1510.555, + 110.79599999999982 + ], + "priority": 17, + "parents": [ + 86655 + ], + "children": [], + "area": 375616.194624, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 4 Quality plot corresponding to library NA1 a) before the preprocessing under parameters trimming 25, at\nleast 80% percent of bases over 25 quality in phred score (T25-Q20-P85), b) after the same preprocessing\nparameters." + }, + { + "id": 86658, + "strid": "4c4252c7-a943-41f3-9dcf-25222edb1026", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 104.06, + 3986.019, + 660.6010000000001, + 504.2829999999999 + ], + "priority": 18, + "parents": [ + 86642 + ], + "children": [], + "area": 414785.13714, + "iscrowd": 0, + "segmentation": [], + "text": "A range of€45% to 78% of filtered\nreads Were mapped (Fig. 5). Overall,\n~18,000. unigenes were predicted.\nSpecific genes responding to each\ncondition were observed. The gene\nexpression analysis shown 143 to 620\nDE gene (Fig. 6). The detected fold\nchange differences (M) of gene\nexpression ranged from -11 to +14\n(Fig. 7)." + }, + { + "id": 86657, + "strid": "492bfebd-abfe-437f-91d5-a714b8a341be", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 789.698, + 3981.202, + 526.054, + 497.71500000000015 + ], + "priority": 19, + "parents": [ + 86642 + ], + "children": [ + 86659 + ], + "area": 3143947.256996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86659, + "strid": "5207ff7e-60d5-42aa-a7ac-c3aeb9cd3b73", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1326.652, + 4017.352, + 300.23900000000003, + 430.1189999999997 + ], + "priority": 20, + "parents": [ + 86657 + ], + "children": [], + "area": 5329628.065504, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 5 Percentage of\nmapped reads _ for\neach library under all\nparameters used for\nthe preprocessin.\nYellow points indicate\nthe percentage of\nmapped for T20-Q20-\nP85 (parameters\nselected for further\nanalysis)." + }, + { + "id": 86660, + "strid": "2d33b4df-4847-4b82-9304-7d3fdef2b9c4", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1752.409, + 986.682, + 1439.147, + 791.655 + ], + "priority": 21, + "parents": [ + 86642 + ], + "children": [ + 86661 + ], + "area": 1729070.4169380001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86661, + "strid": "09b9daf8-7460-46c5-883e-5f6abb79ccca", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1740.093, + 1785.566, + 1469.8680000000002, + 111.55999999999995 + ], + "priority": 22, + "parents": [ + 86660 + ], + "children": [], + "area": 3107050.897638, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 6 Plots of the tagwise log-fold-changes against log-epm (counts per million) with DE genes highlighted for\neach comparison (NA-CABF, NA-CAAF, NA-DA, CABF, GAAF, CABF-DA, CAAF-DA). The horizontal blue lines\nindicates%5-fold change." + }, + { + "id": 86662, + "strid": "1600318e-feb9-4f6c-9ebb-d715182dcdcc", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1792.683, + 1920.118, + 1324.0929999999998, + 806.982 + ], + "priority": 23, + "parents": [ + 86642 + ], + "children": [ + 86663 + ], + "area": 3442162.896594, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86663, + "strid": "7c3b815d-d1d9-488c-acfb-0e173b77ab2b", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1848.761, + 2731.041, + 1186.7289999999998, + 31.101000000000113 + ], + "priority": 24, + "parents": [ + 86662 + ], + "children": [], + "area": 5049042.090201001, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 7 Histograms of up- and down-regulated genes frequencies for each 1.5-value logFC" + }, + { + "id": 86664, + "strid": "e477fb18-ec58-4908-8adf-4fc3f4ed1bad", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1677.3, + 2794.44, + 1515.919, + 144.85699999999997 + ], + "priority": 25, + "parents": [ + 86642 + ], + "children": [], + "area": 4687114.212, + "iscrowd": 0, + "segmentation": [], + "text": "A total of 1,082 acclimation (Fig. 8a)‘and 1,043 de-aclimation (Fig. 8b) responsive\ngenes were identified. Ten genes with the lowest coefficient of variation (CV) were\nselected as candidate reference genes for qRT-PCR validation (Table 1)." + }, + { + "id": 86665, + "strid": "82e20d90-e73a-4935-93f2-80ce150c46a9", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1676.002, + 2958.252, + 1055.9810000000002, + 540.0189999999998 + ], + "priority": 26, + "parents": [ + 86642 + ], + "children": [ + 86667 + ], + "area": 4958036.268503999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86667, + "strid": "29c6a404-465a-4375-b082-d143fca644ff", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2736.332, + 2982.828, + 463.991, + 513.3870000000002 + ], + "priority": 27, + "parents": [ + 86665 + ], + "children": [], + "area": 8162007.706896, + "iscrowd": 0, + "segmentation": [], + "text": "Fig.8 3-set Venn. “diagram\ngenerated by .VennPlex. The\nnumbers in@each, section show\nthe number‘and type (up-, down-\nor contra-regulated)\ntranscriptional alterations. The\nboxed*key indicate the number of\nfactors in each set or intersection\nthat are upregulated (italic),\ndownregulated (underlined) or\ncontra-regulated (red). a) cold\nacclimation responsive genes, b)\nde-acclimation responsive genes" + }, + { + "id": 86668, + "strid": "5bb8cd4d-9924-421c-9315-cf06388d0593", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1805.398, + 3569.195, + 1353.3930000000003, + 350.30700000000024 + ], + "priority": 28, + "parents": [ + 86642 + ], + "children": [ + 86666 + ], + "area": 6443817.51461, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86666, + "strid": "390f352a-b994-403d-8b3e-a35da6db65bf", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2071.334, + 3526.016, + 811.3289999999997, + 31.755999999999858 + ], + "priority": 29, + "parents": [ + 86668 + ], + "children": [], + "area": 7303556.825344, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1. Top ten genes sorted-by.coefficient of variation (CV)" + }, + { + "id": 86644, + "strid": "06f5fc67-b6ce-48ae-a8d8-7fd3edce9476", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2330.703, + 3964.113, + 263.96000000000004, + 43.88299999999981 + ], + "priority": 30, + "parents": [ + 86673 + ], + "children": [ + 86669 + ], + "area": 9239170.061439, + "iscrowd": 0, + "segmentation": [], + "text": "Gonclusions" + }, + { + "id": 86669, + "strid": "aeb8052d-6cb8-489a-b7ad-515bb7e77217", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1693.902, + 4046.686, + 1527.781, + 246.30700000000024 + ], + "priority": 31, + "parents": [ + 86644 + ], + "children": [], + "area": 6854689.508772001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86672, + "strid": "cf0e0568-6509-4caa-b3e8-f24fd1799d66", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 691.349, + 4500.538, + 339.18899999999996, + 38.511999999999716 + ], + "priority": 32, + "parents": [ + 86673 + ], + "children": [ + 86671 + ], + "area": 3111442.445762, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgments:" + }, + { + "id": 86671, + "strid": "fe320a29-65aa-46e0-b00b-cb2a02710507", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1046.896, + 4501.185, + 1562.41, + 38.126000000000204 + ], + "priority": 33, + "parents": [ + 86672 + ], + "children": [], + "area": 4712272.571760001, + "iscrowd": 0, + "segmentation": [], + "text": "Finantial support came from-Fondecyt Iniciacion N2 11121559 and Genomica Forestal S.A." + }, + { + "id": 86643, + "strid": "7606e6a5-9303-40f8-8fb8-1708c311fb54", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2346.124, + 4333.424, + 241.17799999999988, + 41.970000000000255 + ], + "priority": 34, + "parents": [ + 86673 + ], + "children": [ + 86670 + ], + "area": 10166750.048576, + "iscrowd": 0, + "segmentation": [], + "text": "Yay TeV Re Aae" + }, + { + "id": 86670, + "strid": "c491d61e-4470-4821-b448-24694a016cee", + "image_id": 203871, + "image_name": "121078.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1698.006, + 4404.639, + 1508.3440000000003, + 71.12299999999959 + ], + "priority": 35, + "parents": [ + 86643 + ], + "children": [], + "area": 7479103.449834, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 101519, + "strid": "55c0e40a-a595-410e-a2fa-70cafcdc2788", + "image_id": 204420, + "image_name": "122088.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 35.81, + 61.2, + 288.29, + 258.72 + ], + "priority": -1, + "parents": [], + "children": [ + 101512, + 101510, + 101501, + 101500, + 101497, + 101495, + 101496 + ], + "area": 2191.572, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 101495, + "strid": "2f840bea-d190-472d-8967-a209cea096b5", + "image_id": 204420, + "image_name": "122088.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 396.051, + 69.352, + 5206.787, + 111.13500000000002 + ], + "priority": 1, + "parents": [ + 101519 + ], + "children": [], + "area": 27466.928952000002, + "iscrowd": 0, + "segmentation": [], + "text": "Baseline Blood Pressure is Associated with PTSD Symptom.Response to Prazosin in-Active Duty Combat Soldiers" + }, + { + "id": 101496, + "strid": "f2f7e905-de15-4505-9911-665baef9db70", + "image_id": 204420, + "image_name": "122088.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 181.209, + 249.346, + 5643.108, + 62.908000000000015 + ], + "priority": 2, + "parents": [ + 101519 + ], + "children": [], + "area": 45183.739314, + "iscrowd": 0, + "segmentation": [], + "text": "Raskind MA’, Peskind ER!:2sMillard S', Petrie EC'2 'VA Northwest Network Mental Illness Research, Education, and Clinical Center, VA Puget Sound Health Care System; and Dept. of 2Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA" + }, + { + "id": 101497, + "strid": "dcb745b0-7e1c-416b-a881-faddeb2317d2", + "image_id": 204420, + "image_name": "122088.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 692.711, + 425.356, + 395.22399999999993, + 59.52199999999999 + ], + "priority": 3, + "parents": [ + 101519 + ], + "children": [ + 101511 + ], + "area": 294648.780116, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 101511, + "strid": "7a79e545-f792-4a89-a6c0-ff53fddcb571", + "image_id": 204420, + "image_name": "122088.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 51.292, + 533.341, + 1579.047, + 681.6240000000001 + ], + "priority": 4, + "parents": [ + 101497 + ], + "children": [], + "area": 27356.126572, + "iscrowd": 0, + "segmentation": [], + "text": "Prazosin, a CNS active alpha-1 adrenoreceptor (AR) antagonist, was demonstrated\neffective for combat trauma PTSD in a randomized controlled trial (RCT) in active\nduty soldiers returned from Iraq and Afghanistan combat deployments’. However,\ntherapeutic response was variable among participants. A possible neurobiologic\nexplanation of variability of prazosin efficacy is variability of responsiveness of the\ncentral nervous system (CNS) alpha-1 AR that regulate the arousal response to\nCNS norepinephrine. Unfortunately, CNS alpha-1 AR responsiveness cannot be\nmeasured directly. However peripheral alpha-1 AR responsiveness can be estimated\nby measuring resting systolic blood pressure (BP) and the maintenance of systolic\nBP following postural change from supine to standing. Because peripheral and CNS\nnoradrenergic activity are co-regulated in most situations, we hypothesize that higher\nsystolic BP and smaller orthostatic systolic BP reduction at BASELINE would be\nassociated with greater therapeutic response to prazosin in combat trauma PTSD." + }, + { + "id": 101512, + "strid": "140bc9dc-22f3-4cce-95c1-4385a460e60d", + "image_id": 204420, + "image_name": "122088.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 753.751, + 1277.472, + 275.32899999999995, + 55.06600000000003 + ], + "priority": 5, + "parents": [ + 101519 + ], + "children": [ + 101517, + 101513, + 101518, + 101514 + ], + "area": 962895.797472, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 101513, + "strid": "bfefac9a-635a-460d-b5d9-e64a520874eb", + "image_id": 204420, + "image_name": "122088.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 52.78, + 1374.209, + 1637.089, + 349.74199999999996 + ], + "priority": 6, + "parents": [ + 101512 + ], + "children": [], + "area": 72530.75102000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 101514, + "strid": "3502c87b-f159-43f6-ba49-224d56394ae0", + "image_id": 204420, + "image_name": "122088.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 52.78, + 1781.993, + 1623.694, + 513.451 + ], + "priority": 7, + "parents": [ + 101512 + ], + "children": [], + "area": 94053.59054, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 101518, + "strid": "8c4e199e-2975-499f-98dc-2976eeef9c68", + "image_id": 204420, + "image_name": "122088.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 60.855, + 2455.546, + 1609.03, + 557.4360000000001 + ], + "priority": 8, + "parents": [ + 101512 + ], + "children": [ + 101515 + ], + "area": 149432.25183, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 101515, + "strid": "c86f13ed-fb02-4e91-8e2c-1f1e39a02a78", + "image_id": 204420, + "image_name": "122088.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 59.348, + 2389.256, + 635.778, + 49.7170000000001 + ], + "priority": 9, + "parents": [ + 101518 + ], + "children": [], + "area": 141797.565088, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1. Titration Schedule" + }, + { + "id": 101517, + "strid": "095eb471-96b2-4f06-ac67-42b22f88dec0", + "image_id": 204420, + "image_name": "122088.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 60.855, + 3138.028, + 1612.043, + 376.6460000000002 + ], + "priority": 10, + "parents": [ + 101512 + ], + "children": [ + 101516 + ], + "area": 190964.69393999997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 101516, + "strid": "d7624e31-d569-432e-bfa1-48050b509402", + "image_id": 204420, + "image_name": "122088.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 57.842, + 3076.258, + 548.396, + 54.23700000000008 + ], + "priority": 11, + "parents": [ + 101517 + ], + "children": [], + "area": 177936.91523599997, + "iscrowd": 0, + "segmentation": [], + "text": "Table 2. Demographics" + }, + { + "id": 101510, + "strid": "575c0e84-633b-44bb-9e69-2d33af7dd2aa", + "image_id": 204420, + "image_name": "122088.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2481.624, + 430.651, + 250.0279999999998, + 56.55400000000003 + ], + "priority": 12, + "parents": [ + 101519 + ], + "children": [ + 101505, + 101506, + 101507, + 101499, + 101504, + 101509 + ], + "area": 1068713.857224, + "iscrowd": 0, + "segmentation": [], + "text": "RESULTS" + }, + { + "id": 101509, + "strid": "0daeef83-808c-4903-9116-04817bf562f6", + "image_id": 204420, + "image_name": "122088.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1773.211, + 542.27, + 1620.718, + 349.74199999999996 + ], + "priority": 13, + "parents": [ + 101510 + ], + "children": [], + "area": 961559.12897, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 101507, + "strid": "4f52f09e-a8bb-47a6-ae5c-ea119ecdf81b", + "image_id": 204420, + "image_name": "122088.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1767.638, + 1114.034, + 1619.1419999999998, + 2017.067 + ], + "priority": 14, + "parents": [ + 101510 + ], + "children": [ + 101508 + ], + "area": 1969208.8316920002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 101508, + "strid": "b203f01c-3e99-4888-a3b9-0bf32eff14dd", + "image_id": 204420, + "image_name": "122088.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1774.7, + 963.449, + 1608.8119999999997, + 125.01400000000001 + ], + "priority": 15, + "parents": [ + 101507 + ], + "children": [], + "area": 1709832.9403, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. Effects of prazosin vs. placebo on symptom ratings in\nactive-duty soldiers with combat trauma-related PTSD with nightmares" + }, + { + "id": 101505, + "strid": "85fa6eb7-72db-45b6-9d00-e92c3988a6f3", + "image_id": 204420, + "image_name": "122088.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1780.624, + 3210.835, + 1607.6829999999998, + 43.56899999999996 + ], + "priority": 16, + "parents": [ + 101510 + ], + "children": [], + "area": 5717289.86104, + "iscrowd": 0, + "segmentation": [], + "text": "Conflict of Interest Statement: the co-authors have no financial conflict of interest with respect to this research." + }, + { + "id": 101506, + "strid": "4ed77a02-eded-4f93-9c27-c659f2ff1423", + "image_id": 204420, + "image_name": "122088.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1779.172, + 3271.831, + 1601.8740000000003, + 87.13700000000017 + ], + "priority": 17, + "parents": [ + 101510 + ], + "children": [], + "area": 5821150.103932001, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements: This research was supported by the Department of Defense Congressionally Directed\nMedical Research Program (CDMRP) and the Department of Veterans Affairs" + }, + { + "id": 101499, + "strid": "8dd64d1d-e1ed-4804-972f-06e0b2690590", + "image_id": 204420, + "image_name": "122088.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3737.444, + 626.143, + 1930.4870000000005, + 1720.1769999999997 + ], + "priority": 18, + "parents": [ + 101510 + ], + "children": [ + 101498 + ], + "area": 2340174.398492, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 101498, + "strid": "6f6c83cb-0f3c-49e5-bef5-09f8bf7f11ec", + "image_id": 204420, + "image_name": "122088.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 3493.405, + 441.626, + 2422.533, + 128.96399999999994 + ], + "priority": 19, + "parents": [ + 101499 + ], + "children": [], + "area": 1542778.47653, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2. Prazosin group: effect of baseline systolic blood pressure (standing for 2 minutes from supine)\non response to symptom ratings in active duty soldiers with combat trauma-related PTSD with nightmares" + }, + { + "id": 101504, + "strid": "5e37705c-6de1-48c5-b7e8-e4e53dc2987d", + "image_id": 204420, + "image_name": "122088.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3503.325, + 2437.586, + 2440.389, + 468.2370000000001 + ], + "priority": 20, + "parents": [ + 101510 + ], + "children": [], + "area": 8539655.97345, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 101500, + "strid": "97102538-888c-47c9-8447-fcf6d5904fde", + "image_id": 204420, + "image_name": "122088.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4564.795, + 2961.377, + 361.09799999999996, + 61.50599999999986 + ], + "priority": 21, + "parents": [ + 101519 + ], + "children": [ + 101502 + ], + "area": 13518078.922715, + "iscrowd": 0, + "segmentation": [], + "text": "DISCUSSION" + }, + { + "id": 101502, + "strid": "b07e4a0a-605b-46cc-8505-bfbdd9ee1301", + "image_id": 204420, + "image_name": "122088.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3493.405, + 3050.66, + 2331.266, + 220.23000000000002 + ], + "priority": 22, + "parents": [ + 101500 + ], + "children": [], + "area": 10657190.8973, + "iscrowd": 0, + "segmentation": [], + "text": "Higher baseline BP and smaller baseline BP drop are associated with substantially greater PTSD symptom improvement with\nprazosin treatment. These results suggest that peripheral BP, which reflects increased peripheral alpha-1 AR responsiveness,\nprovides an indicator of increased CNS alpha-1 AR responsiveness in combat trauma PTSD. Such increased alpha-1 AR\nresponsiveness and/or activation are the presumed target for prazosin therapeutic efficacy." + }, + { + "id": 101501, + "strid": "aa646bc5-be9c-4166-b245-25727071ece8", + "image_id": 204420, + "image_name": "122088.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4542.971, + 3340.332, + 404.7479999999996, + 57.53800000000001 + ], + "priority": 23, + "parents": [ + 101519 + ], + "children": [ + 101503 + ], + "area": 15175031.406371998, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 101503, + "strid": "e20a45c0-7989-4ad6-9223-dac537a1a735", + "image_id": 204420, + "image_name": "122088.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3497.373, + 3433.583, + 2368.963, + 103.17099999999982 + ], + "priority": 24, + "parents": [ + 101501 + ], + "children": [], + "area": 12008520.477459, + "iscrowd": 0, + "segmentation": [], + "text": "Baseline BP could be a clinically useful biomarker for helping to predict the response to prazosin or other alpha-1 AR antagonist\ntreatment outcomes in PTSD." + }, + { + "id": 7063, + "strid": "29f6e3d4-8a77-4476-8cab-13caa979b071", + "image_id": 200784, + "image_name": "10963.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 66.59, + 74.74, + 120.82, + 199.63 + ], + "priority": -1, + "parents": [], + "children": [ + 7065, + 7066, + 7071, + 7074, + 7075, + 7064, + 7079 + ], + "area": 4976.9366, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 7064, + "strid": "44fd815f-698a-42ad-a561-dec109fd03b8", + "image_id": 200784, + "image_name": "10963.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 1084.703, + 112.69, + 2889.506, + 122.394 + ], + "priority": 1, + "parents": [ + 7063 + ], + "children": [], + "area": 122235.18106999999, + "iscrowd": 0, + "segmentation": [], + "text": "Temporal Properties of Mirror-Symmetry Perception" + }, + { + "id": 7065, + "strid": "e90f0612-32e1-4960-821c-9583921df8aa", + "image_id": 200784, + "image_name": "10963.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1433.231, + 270.346, + 2192.3010000000004, + 124.50900000000001 + ], + "priority": 2, + "parents": [ + 7063 + ], + "children": [], + "area": 387468.267926, + "iscrowd": 0, + "segmentation": [], + "text": "Rebecca J. Sharman & Elena Gheorghiu\nUniversity of Stirling, Faculty of Natural Sciences, Department of Psychology, Stirling, FK9 4LA, Scotland" + }, + { + "id": 7066, + "strid": "45ba703e-d15f-4946-9553-1e9311078ed9", + "image_id": 200784, + "image_name": "10963.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 114.745, + 489.786, + 431.582, + 67.714 + ], + "priority": 3, + "parents": [ + 7063 + ], + "children": [ + 7067, + 7069 + ], + "area": 56200.49457, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 7069, + "strid": "0d74b36c-c040-4032-9a7a-f4f556369cda", + "image_id": 200784, + "image_name": "10963.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 88.468, + 600.984, + 1377.766, + 205.87599999999998 + ], + "priority": 4, + "parents": [ + 7066 + ], + "children": [], + "area": 53167.852512000005, + "iscrowd": 0, + "segmentation": [], + "text": "The human visual system has specialised mechanisms for\nencoding mirror-symmetry. Recent studies suggest that temporal\ndynamics contribute to mirror-symmetry perception (Sharman &\nGheorghiu 2017). Here we investigate:" + }, + { + "id": 7067, + "strid": "f3f222b8-f64d-4047-a2fd-bf5194a99f70", + "image_id": 200784, + "image_name": "10963.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 90.491, + 811.615, + 1418.963, + 256.69600000000014 + ], + "priority": 5, + "parents": [ + 7066 + ], + "children": [], + "area": 73443.852965, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 7071, + "strid": "f62984ad-09ee-412a-979c-a9d2cefc13fc", + "image_id": 200784, + "image_name": "10963.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 91.266, + 1141.098, + 307.903, + 81.02700000000004 + ], + "priority": 6, + "parents": [ + 7063 + ], + "children": [ + 7068, + 7080, + 7072, + 7073, + 7076, + 7083 + ], + "area": 104143.450068, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 7072, + "strid": "2bc848da-7049-4afd-8653-8c254e21e175", + "image_id": 200784, + "image_name": "10963.png", + "category_id": 4, + "category_name": "List", 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Participants" + }, + { + "id": 7086, + "strid": "e5434f0d-7005-4194-9b30-b3ee3e797f7b", + "image_id": 200784, + "image_name": "10963.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1607.547, + 757.853, + 1284.768, + 899.764 + ], + "priority": 15, + "parents": [ + 7075 + ], + "children": [], + "area": 1218284.316591, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 7087, + "strid": "f78f7a68-28db-4fb9-a0d1-d4a2decf3fbb", + "image_id": 200784, + "image_name": "10963.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1898.584, + 1691.133, + 701.5290000000002, + 527.9359999999999 + ], + "priority": 16, + "parents": [ + 7075 + ], + "children": [], + "area": 3210758.055672, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 7081, + "strid": "f01620c5-7413-42e5-a87c-0d63524244cb", + "image_id": 200784, + "image_name": "10963.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1603.886, + 2257.99, + 1294.688, + 308.99699999999984 + 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"Figure", + "bbox": [ + 4030.344, + 1775.924, + 701.192, + 583.3690000000001 + ], + "priority": 22, + "parents": [ + 7075 + ], + "children": [], + "area": 7157584.637856, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 7084, + "strid": "c446fb00-34b3-46cf-8b87-751ded861398", + "image_id": 200784, + "image_name": "10963.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2961.364, + 2371.255, + 1919.4699999999998, + 206.0010000000002 + ], + "priority": 23, + "parents": [ + 7075 + ], + "children": [], + "area": 7022149.19182, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 7079, + "strid": "7fbdaf44-8fb7-4876-8ed4-b7c7d55af8a6", + "image_id": 200784, + "image_name": "10963.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1616.171, + 2638.183, + 415.78, + 67.69599999999991 + ], + "priority": 24, + "parents": [ + 7063 + ], + "children": [ + 7077 + ], + "area": 4263754.857293, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 7077, + "strid": "f222b21d-0f35-4399-85ea-06c6019b8455", + "image_id": 200784, + "image_name": "10963.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1611.442, + 2746.112, + 3163.183, + 282.0920000000001 + ], + "priority": 25, + "parents": [ + 7079 + ], + "children": [], + "area": 4425200.213504001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 7074, + "strid": "fce93eef-c14e-4a1f-aa6a-e44ab280e581", + "image_id": 200784, + "image_name": "10963.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1601.358, + 3088.849, + 2132.879, + 150.73300000000017 + ], + "priority": 26, + "parents": [ + 7063 + ], + "children": [], + "area": 4946353.056942, + "iscrowd": 0, + "segmentation": [], + "text": "References & Acknowledgements\nSharman, R.J. & Gheorghiu, E. (2017) The role of motion and number of element locations in mirror symmetry perception. Scientific Reports. 7, 45679.\n\n \n\nThis research was supported by a Wellcome Trust Investigator grant (WT106969/Z/15/Z) given to EG." + }, + { + "id": 97050, + "strid": "79c2e390-f9bd-44b4-8a25-69a4a612b79e", + "image_id": 204252, + "image_name": "121730.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 13.34, + 110.55, + 147.5, + 261.49 + ], + "priority": -1, + "parents": [], + "children": [ + 97025, + 97027, + 97026 + ], + "area": 1474.7369999999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 97025, + "strid": "2f303aa6-1da7-4541-a9c6-ee48b92e64b9", + "image_id": 204252, + "image_name": "121730.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 222.825, + 170.419, + 1824.665, + 207.68299999999996 + ], + "priority": 1, + "parents": [ + 97050 + ], + "children": [], + "area": 37973.613675, + "iscrowd": 0, + "segmentation": [], + "text": "Long-term consistency in spatial patterns\nof primate seed dispersal" + }, + { + "id": 97026, + "strid": "c553b04a-034d-4cfe-a84f-d070844c86c0", + "image_id": 204252, + "image_name": "121730.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 228.278, + 436.277, + 2522.248, + 265.724 + ], + "priority": 2, + "parents": [ + 97050 + ], + "children": [], + "area": 99592.441006, + "iscrowd": 0, + "segmentation": [], + "text": "Eckhard W. Heymann”, Christoph Knogge’, Laurence Culot*4, Emérita R. Tirado Herrera®, Dietmar Zinner®\n\n'Verhaltensdkologie & Soziobiologie, Deutsches Primatenzentrum, Gottingen, Germany; 2current: Nazaré Paulista, Sao Paulo, Brazil;\n3Departamento de Zoologia, Universidade Estadual Paulista, Rio Claro, Brazil; 4Primatology Research Group, Behavioral Biology Unit,\nUniversity of Liege, Belgium; SFacultad de Ciencias Bioldgicas, Universidad Nacional de la Amazonia Peruana, Iquitos, Peru;\nSKognitive Ethologie, Deutsches Primatenzentrum, Gottingen, Germany; “eheyman@gwdg.de" + }, + { + "id": 97027, + "strid": "c3b1dc50-9718-42d5-950f-a4b66b07e37f", + "image_id": 204252, + "image_name": "121730.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 269.813, + 832.564, + 2771.97, + 230.99799999999993 + ], + "priority": 3, + "parents": [ + 97050 + ], + "children": [ + 97034, + 97031, + 97028, + 97036, + 97033, + 97030, + 97046, + 97040, + 97032, + 97038, + 97039, + 97048, + 97029, + 97037, + 97049, + 97035, + 97047 + ], + "area": 224636.59053199997, + "iscrowd": 0, + "segmentation": [], + "text": "Take-home message:\nSpatial patterns of primate seed dispersal are consistent.over time" + }, + { + "id": 97028, + "strid": "5889dee0-83c4-4590-85eb-2f6f55689971", + "image_id": 204252, + "image_name": "121730.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 234.661, + 1103.735, + 2834.741, + 537.3199999999999 + ], + "priority": 4, + "parents": [ + 97027 + ], + "children": [], + "area": 259003.55883499997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 97029, + "strid": "ee64f001-b5bd-4435-9626-76336bb60c2a", + "image_id": 204252, + "image_name": "121730.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 244.175, + 1754.641, + 1496.992, + 200.9760000000001 + ], + "priority": 5, + "parents": [ + 97027 + ], + "children": [], + "area": 428439.46617500007, + "iscrowd": 0, + "segmentation": [], + "text": "Research question\nHow consistent are spatial patterns of primate seed dispersal,\nspecifically seed dispersal distances, over time?" + }, + { + "id": 97030, + "strid": "def8e8b4-91ff-4696-b01b-266edbf87542", + "image_id": 204252, + "image_name": "121730.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 239.683, + 2093.007, + 1637.069, + 218.4430000000002 + ], + "priority": 6, + "parents": [ + 97027 + ], + "children": [], + "area": 501658.196781, + "iscrowd": 0, + "segmentation": [], + "text": "Model system\nPrimates: Saguinus mystax and Saguinus nigrifrons (Callitrichidae)\nPlants: >100 plant species dispersed by these primates" + }, + { + "id": 97036, + "strid": "7c2c2097-a7df-4239-a22b-4e6a0fc85239", + "image_id": 204252, + "image_name": "121730.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2028.98, + 1703.495, + 272.201, + 371.6819999999998 + ], + "priority": 7, + "parents": [ + 97027 + ], + "children": [ + 97041 + ], + "area": 3456357.2851, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 97041, + "strid": "ea5b712a-4d81-447c-b72d-c912ac58da7b", + "image_id": 204252, + "image_name": "121730.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2058.886, + 2082.501, + 216.05200000000013, + 32.95699999999988 + ], + "priority": 8, + "parents": [ + 97036 + ], + "children": [], + "area": 4287632.153886001, + "iscrowd": 0, + "segmentation": [], + "text": "Saguinus mystax" + }, + { + "id": 97037, + "strid": "2706d603-f277-412c-8cd3-fe11b0b434fa", + "image_id": 204252, + "image_name": "121730.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2339.02, + 1707.157, + 612.1460000000002, + 368.01999999999975 + ], + "priority": 9, + "parents": [ + 97027 + ], + "children": [ + 97042 + ], + "area": 3993074.3661399996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 97042, + "strid": "1fe2657a-447c-486c-995d-d9dc5c0486af", + "image_id": 204252, + "image_name": "121730.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2350.006, + 2081.28, + 582.241, + 33.56700000000001 + ], + "priority": 10, + "parents": [ + 97037 + ], + "children": [], + "area": 4891020.48768, + "iscrowd": 0, + "segmentation": [], + "text": "Saguinus nigrifrons feeding in a Pourouma tree" + }, + { + "id": 97038, + "strid": "fd003029-a060-4097-89fc-77723fccfb92", + "image_id": 204252, + "image_name": "121730.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2027.759, + 2129.495, + 272.81100000000015, + 364.96900000000005 + ], + "priority": 11, + "parents": [ + 97027 + ], + "children": [ + 97043 + ], + "area": 4318102.651705, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 97043, + "strid": "00050595-3151-4582-9abe-2dc72c2d5fa0", + "image_id": 204252, + "image_name": "121730.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2043.084, + 2500.269, + 241.836, + 31.773999999999887 + ], + "priority": 12, + "parents": [ + 97038 + ], + "children": [], + "area": 5108259.589596, + "iscrowd": 0, + "segmentation": [], + "text": "Saguinus nigrifrons" + }, + { + "id": 97039, + "strid": "76b4509c-dacc-44a9-adba-7c4ce8ffa3d8", + "image_id": 204252, + "image_name": "121730.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2340.851, + 2130.105, + 261.8249999999998, + 363.74800000000005 + ], + "priority": 13, + "parents": [ + 97027 + ], + "children": [ + 97044 + ], + "area": 4986258.419355, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 97044, + "strid": "d8b167e4-f065-418b-900d-140e51cb84a5", + "image_id": 204252, + "image_name": "121730.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2351.557, + 2499.387, + 236.98099999999977, + 65.75500000000011 + ], + "priority": 14, + "parents": [ + 97039 + ], + "children": [], + "area": 5877450.9955589995, + "iscrowd": 0, + "segmentation": [], + "text": "Seed defecated by\ntamarin, in situ" + }, + { + "id": 97040, + "strid": "d67ad337-06ea-47f8-90ed-ef1fc0166e84", + "image_id": 204252, + "image_name": "121730.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2641.737, + 2128.274, + 310.65099999999984, + 364.96900000000005 + ], + "priority": 15, + "parents": [ + 97027 + ], + "children": [ + 97045 + ], + "area": 5622340.171938, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 97045, + "strid": "d6d0d402-6ceb-45f5-8a12-852245aada87", + "image_id": 204252, + "image_name": "121730.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2660.03, + 2499.828, + 275.8159999999998, + 67.07900000000018 + ], + "priority": 16, + "parents": [ + 97040 + ], + "children": [], + "area": 6649617.47484, + "iscrowd": 0, + "segmentation": [], + "text": "Examples of seeds\ndispersed by tamarins" + }, + { + "id": 97049, + "strid": "068195bc-384b-4be0-b0b7-70f6acc5cbec", + "image_id": 204252, + "image_name": "121730.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 245.384, + 2492.169, + 226.12299999999996, + 59.03200000000015 + ], + "priority": 17, + "parents": [ + 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"image_id": 204252, + "image_name": "121730.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1078.295, + 2591.727, + 780.248, + 597.3980000000001 + ], + "priority": 20, + "parents": [ + 97027 + ], + "children": [], + "area": 2794646.265465, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 97047, + "strid": "650de754-57ff-4ab2-b9f6-8ad5bbed5939", + "image_id": 204252, + "image_name": "121730.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1103.842, + 3213.521, + 845.232, + 196.27100000000019 + ], + "priority": 21, + "parents": [ + 97027 + ], + "children": [], + "area": 3547219.4476820007, + "iscrowd": 0, + "segmentation": [], + "text": "Distributions of dispersal distances\nvary between periods\n(Chi?=62.907, df=14, p<0.01)" + }, + { + "id": 97035, + "strid": "adaa821c-9ff2-440e-bd25-157ca1d33ec3", + "image_id": 204252, + "image_name": "121730.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2137.728, + 2593.332, + 779.569, + 594.31 + ], + "priority": 22, + "parents": [ + 97027 + ], + "children": [], + "area": 5543838.429696, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 97048, + "strid": "37fc1287-2473-46ff-b1a6-df5c538dc365", + "image_id": 204252, + "image_name": "121730.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2122.822, + 3218.557, + 984.0370000000003, + 194.64499999999998 + ], + "priority": 23, + "parents": [ + 97027 + ], + "children": [], + "area": 6832423.607854, + "iscrowd": 0, + "segmentation": [], + "text": "Cumulative dispersal curves do not vary\nbetween periods (and disperser species;\nall r>0.996, p<0.001)" + }, + { + "id": 97031, + "strid": "86eb9763-8092-4108-8994-aa8376248ab6", + "image_id": 204252, + "image_name": "121730.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 241.979, + 3474.461, + 2801.603, + 403.2710000000002 + ], + "priority": 24, + "parents": [ + 97027 + ], + "children": [], + "area": 840746.598319, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion & Conclusion\n\nDespite differences between siudy periods in distributions of dispersal distances, mean dispersal distances and\ncumulative dispersal curves are consistent over time. It can thus be expected that over ecological time scales, the\ninfluence of the dispersal vectors on the spatial structure of plant populations is consistent, which needs to be tested\nwith specific plant species. Over evolutionary time scales, such a consistency might facilitate diffuse co-evolutionary\nrelationships." + }, + { + "id": 97032, + "strid": "26615398-882a-4e66-b1f2-cc9eb910750e", + "image_id": 204252, + "image_name": "121730.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 235.553, + 3917.068, + 2647.657, + 357.0550000000003 + ], + "priority": 25, + "parents": [ + 97027 + ], + "children": [], + "area": 922677.1186040001, + "iscrowd": 0, + "segmentation": [], + "text": "Methods\n\nStudy site: Estacion Bioldgica Quebrada Blanco, Peruvian Amazonia, 4°21’S 73°09’W\n\nStudy periods: February 1994-May 1995; September 2005-May 2008 (four 6-month periods)\n\nField methods: data collection on feeding behaviour of a mixed-species group of S. mystax and S. nigrifrons; collection of faecal samples with seeds;\nmapping (1994-95)/geo-referencing (2005-08) of food plants and defecation sites\n\nData analyses: dispersal distance=linear distance between food plant and defecation site; 1-way ANOVA for comparison of mean dispersal distances;\nChi? test for comparison of distributions; Pearson product-moment correlation for cumulative dispersal curves" + }, + { + "id": 50913, + "strid": "21cff258-19f5-4b38-a2cc-28f237d371e0", + "image_id": 202502, + "image_name": "118783.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 90.85, + 182.37, + 293.39, + 325.99 + ], + "priority": -1, + "parents": [], + "children": [ + 50897, + 50898, + 50899, + 50895, + 50896 + ], + "area": 16568.3145, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 50895, + "strid": "4cb2d5a9-1fee-477e-8153-d3afdbf0391c", + "image_id": 202502, + "image_name": "118783.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 289.517, + 176.8, + 2137.618, + 131.27299999999997 + ], + "priority": 1, + "parents": [ + 50913 + ], + "children": [], + "area": 51186.6056, + "iscrowd": 0, + "segmentation": [], + "text": "DIAGNOSTIC Re eae ERRORSJN CLUSTER HEADACHE: A\n; POPULATION-BASED STUDY a" + }, + { + "id": 50896, + "strid": "75f89eff-1560-4f03-a156-f1ed961aaa29", + "image_id": 202502, + "image_name": "118783.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 530.776, + 352.421, + 1710.094, + 218.19699999999995 + ], + "priority": 2, + "parents": [ + 50913 + ], + "children": [], + "area": 187056.60869599998, + "iscrowd": 0, + "segmentation": [], + "text": "Fabio Antonaci', Marta Allena’, Cristina Voiticovschi?, Ilaria De Cillis', Giuseppe Nappit\n\n‘Pavia Headache Center, C. Mondino.National Institute of Neurology Foundation,\n\nIRCCS) University of Pavia\n2 State Medical and Pharmaceutical University “Nicolae Testemitanu”, Republic of Moldova" + }, + { + "id": 50897, + "strid": "81be59a3-b72d-4d5f-854c-82440a877c64", + "image_id": 202502, + "image_name": "118783.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 486.427, + 797.685, + 455.90700000000004, + 58.54099999999994 + ], + "priority": 3, + "parents": [ + 50913 + ], + "children": [ + 50901, + 50904, + 50900 + ], + "area": 388015.521495, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 50904, + "strid": "2668168e-df2b-45f5-99e3-7290fb625ac7", + "image_id": 202502, + "image_name": "118783.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 114.132, + 880.967, + 398.671, + 531.478 + ], + "priority": 4, + "parents": [ + 50897 + ], + "children": [], + "area": 100546.52564400001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 50900, + "strid": "1d5d8074-7ff7-4c80-af95-1ba0131f9ff3", + "image_id": 202502, + "image_name": "118783.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 584.083, + 881.877, + 721.5499999999998, + 522.935 + ], + "priority": 5, + "parents": [ + 50897 + ], + "children": [], + "area": 515089.3637909999, + "iscrowd": 0, + "segmentation": [], + "text": "Cluster headache’is a severe,\ndisabling forny of headache.\nDespite thewell defined clinical\ndescription, it seems that the\ndiagnosis of CH is often missed or\ndelayed in clinical practice (Klapper\n2000; Bahra A. 2002)\n\nCH patients face: misdiagnosys,\nuseless investigations, delay in\nadequate treatment." + }, + { + "id": 50901, + "strid": "ade859af-19be-4167-b34c-35e3eb69b7cb", + "image_id": 202502, + "image_name": "118783.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 81.261, + 1558.173, + 1239.457, + 150.84699999999998 + ], + "priority": 6, + "parents": [ + 50897 + ], + "children": [], + "area": 126618.696153, + "iscrowd": 0, + "segmentation": [], + "text": "Aim of the study: identify the diagnostic and therapeutic,errors in CH\nin order=to improve the clinical and instrumental workup in these\npatients." + }, + { + "id": 50898, + "strid": "1b63ced9-8895-4363-9cba-b4a5c766245c", + "image_id": 202502, + "image_name": "118783.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 312.579, + 1759.169, + 789.4110000000001, + 56.76700000000005 + ], + "priority": 7, + "parents": [ + 50913 + ], + "children": [ + 50906, + 50902, + 50909, + 50910, + 50912, + 50907, + 50908, + 50905, + 50911 + ], + "area": 549879.286851, + "iscrowd": 0, + "segmentation": [], + "text": "MATERIALS AND MBMHODS" + }, + { + "id": 50902, + "strid": "1a1647eb-d80f-4667-a5de-dcd812b3d589", + "image_id": 202502, + "image_name": "118783.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 98.859, + 1882.494, + 1221.858, + 1123.8079999999998 + ], + "priority": 8, + "parents": [ + 50898 + ], + "children": [], + "area": 186101.47434599997, + "iscrowd": 0, + "segmentation": [], + "text": "Our study included 144 ECH patients: 106 Italians, 28\nfrom abroad (Moldova, Ukraine, Bulgaria). Methods: ad\nhoc questionnaire (frontal/telephone interview). Sex\ndistribution M= 106; F= 38.\\Age range group: 20-40yrs= 63;\n40-60yrs= 65; >60yrs= 16. Working position: worker 43;\nemployee 41; manager 12; managing director 6;\nunemployed 20; other 22.\n\nSeeking for physician at the first CH attack: Yes 110\n(76%); No-34 (24%). Neurologist= 81 (56%); PCP= 52\n(36%); ENT= 21 (15%); Dentist= 8 (6%); Others= 6(4%).\nFirst Time diagnosis at interview: Yes= 109 (76%) No= 35\n(24%).\n\nKnowledge about the existence of Headache Centers:\nYes= 82% (It 89%; F 11%), No= 18% (It'11%; F 89%)\nComorbidity of CH: Yes= 23%, (MwoA= 49%, MwA= 6%,\nTTH= 36%, Others= 9%). No= 77%,\n\nInvestigations carried out prior-to diagnosis of CH:\nYes= 134 (93%), (Brain MRI5\\55%, brain CT= 49%, Scalp\nX-Ray= 11%, Another= 25%). No= 10 (7%).\n\nMedical prescription Compliance: Yes= 126 (88%) No=\ntae.)" + }, + { + "id": 50905, + "strid": "92956c4d-228a-49e0-a7e8-25dc1ed01ba6", + "image_id": 202502, + "image_name": "118783.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1522.507, + 718.205, + 865.6529999999998, + 258.7130000000001 + ], + "priority": 9, + "parents": [ + 50898 + ], + "children": [], + "area": 1093472.139935, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 50906, + "strid": "da690018-22c3-4c01-990b-a7de31bd9c66", + "image_id": 202502, + "image_name": "118783.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1481.482, + 1065.183, + 1071.2269999999999, + 308.21299999999997 + ], + "priority": 10, + "parents": [ + 50898 + ], + "children": [], + "area": 1578049.441206, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 50907, + "strid": "25eba634-921e-4e57-8555-c37ee025283e", + "image_id": 202502, + "image_name": "118783.png", + "category_id": 2, + 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F. C. Gomes®», Isaure C. de Beauchéneé®, Nicolas Panel, Pedro G. Pascutti>s Eric Solary®, Luba Tchertanov?.\n@ Laboratoire de Biologie et Pharmacologie Appliquée (LBPA), UMR8113, CNRSENS Cachan, France\n\nb Instituto de Biofisica Carlos Ghagas Filho - Universidade Federal do Rio de Janeiro, Brazil\n\n© Institut Gustave Roussy; Jnserm UMR1009, France | IQ ‘>" + }, + { + "id": 87791, + "strid": "3fdab6b1-4320-4fb5-b52a-b11b320e65b7", + "image_id": 203910, + "image_name": "121143.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 211.76, + 711.532, + 343.88599999999997, + 60.02800000000002 + ], + "priority": 3, + "parents": [ + 87805 + ], + "children": [ + 87792 + ], + "area": 150674.01632, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 87792, + "strid": "8b18f6e3-3afa-4c26-9225-ef4d3ae8c690", + "image_id": 203910, + "image_name": "121143.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 152.392, + 800.968, + 1314.161, + 1038.7070000000003 + ], + "priority": 4, + "parents": [ + 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"36e5af56-24a2-43f6-8a9e-573531bc31ed", + "image_id": 201076, + "image_name": "11601.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 123.416, + 347.414, + 2106.756, + 241.25299999999993 + ], + "priority": 2, + "parents": [ + 14479 + ], + "children": [], + "area": 42876.446224, + "iscrowd": 0, + "segmentation": [], + "text": "Gift Nuka, Matthew Fraser, Alex Mitchell, Simon Potter, Siew-Yit Yong\n& Robert D. Finn\n\nEuropean Bioinformatics Institute (EMBL-EBI), United Kingdom" + }, + { + "id": 14482, + "strid": "7f1b1760-3d4e-4736-b0cb-78551476da66", + "image_id": 201076, + "image_name": "11601.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 153.709, + 751.0, + 382.046, + 48.03600000000006 + ], + "priority": 3, + "parents": [ + 14479 + ], + "children": [ + 14483, + 14484 + ], + "area": 115435.459, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 14484, + "strid": "7fc419ca-97fd-4d03-be3a-a9c51179d656", + "image_id": 201076, + "image_name": "11601.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 150.936, + 811.744, + 1457.395, + 528.802 + ], + "priority": 4, + "parents": [ + 14482 + ], + "children": [], + "area": 122521.392384, + "iscrowd": 0, + "segmentation": [], + "text": "InterPro (http://www.ebi.ac.uk/interpro/) is a freely\navailable database used to _ classify protein\nsequences into families and to predict the presence\nof important domains and sites. The resource is\nbased around diagnostic signatures, provided by\ndifferent member databases, against which protein\nsequences are searched to determine their\npotential functions." + }, + { + "id": 14483, + "strid": "9320e6c4-d0ff-4d75-8762-5a8846779528", + "image_id": 201076, + "image_name": "11601.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 157.547, + 1340.542, + 1450.36, + 929.9410000000003 + ], + "priority": 5, + "parents": [ + 14482 + ], + "children": [ + 14499 + ], + "area": 211198.370474, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 14499, + "strid": "820a94c3-e7e4-4719-bf58-4238fc28ce5e", + "image_id": 201076, + "image_name": "11601.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 140.057, + 2300.009, + 1462.869, + 218.70800000000008 + ], + "priority": 6, + "parents": [ + 14483 + ], + "children": [], + "area": 322132.360513, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1: Fourteen different member databases with differing\nmethods of signature production and biological focuses make up\nthe InterPro resource. Databases with a v provide some form of\nresidue-specific annotation." + }, + { + "id": 14496, + "strid": "02516709-eb3e-42a3-b435-b3c47fe73254", + "image_id": 201076, + "image_name": "11601.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 137.185, + 2562.1, + 347.751, + 53.572000000000116 + ], + "priority": 7, + "parents": [ + 14479 + ], + "children": [ + 14498, + 14492 + ], + "area": 351481.6885, + "iscrowd": 0, + "segmentation": [], + "text": "InterProScan" + }, + { + "id": 14492, + "strid": "9ce58fe3-a4c6-4fde-b01f-f2f9f65ebebc", + "image_id": 201076, + "image_name": "11601.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 136.366, + 2629.284, + 1485.919, + 530.5279999999998 + ], + "priority": 8, + "parents": [ + 14496 + ], + "children": [], + "area": 358544.9419440001, + "iscrowd": 0, + "segmentation": [], + "text": "InterProScan (http://www.ebi.ac.uk/interpro/interproscan.html) is\nthe underlying software application that allows both protein\nand nucleic acid sequences to be scanned against\nInterPro's predictive models (profile hidden Markov\nmodels, profiles, position-specific scoring matrices and\nregular expressions), which are provided by the resource’s\nmember databases. InterProScan produces output in\ndifferent formats including tsv, xml, json and svg." + }, + { + "id": 14498, + "strid": "7dbc56d6-770c-42fc-a87f-1009ef1c10b5", + "image_id": 201076, + "image_name": "11601.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 151.06, + 3175.002, + 1459.169, + 975.011 + ], + "priority": 9, + "parents": [ + 14496 + ], + "children": [ + 14485 + ], + "area": 479615.80212, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 14485, + "strid": "8589236a-e8ea-4e47-9262-6a844aaa5918", + "image_id": 201076, + "image_name": "11601.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 179.365, + 4163.158, + 1467.063, + 153.59100000000035 + ], + "priority": 10, + "parents": [ + 14498 + ], + "children": [], + "area": 746724.8346700001, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2: InterProScan matches for UniProtKB protein Q3JCG5\nshowing predicted protein family membership, domains and\nsites." + }, + { + "id": 14486, + "strid": "18d249a6-4f49-4ff9-86fe-e396a86b9e5f", + "image_id": 201076, + "image_name": "11601.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1707.122, + 747.94, + 782.133, + 53.08100000000002 + ], + "priority": 11, + "parents": [ + 14479 + ], + "children": [ + 14488, + 14487, + 14491 + ], + "area": 1276824.82868, + "iscrowd": 0, + "segmentation": [], + "text": "Residue-level annotation" + }, + { + "id": 14488, + "strid": "8a48a61f-dc53-4820-a2e7-8f5120a72081", + "image_id": 201076, + "image_name": "11601.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1703.827, + 810.624, + 1470.5490000000002, + 395.23800000000006 + ], + "priority": 12, + "parents": [ + 14486 + ], + "children": [], + "area": 1381163.058048, + "iscrowd": 0, + "segmentation": [], + "text": "Two recently added member databases, CDD and\nSFLD, provide specific residue-level annotation,\nenabling identification of important amino acids,\nsuch as those comprising ligand-binding or active\nsites. These provide an additional tier to the\nannotations provided by InterPro." + }, + { + "id": 14487, + "strid": "1fdc71b6-857b-4297-88e2-6c74bb21ede6", + "image_id": 201076, + "image_name": "11601.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1708.272, + 1207.443, + 1275.4409999999998, + 726.137 + ], + "priority": 13, + "parents": [ + 14486 + ], + "children": [ + 14497 + ], + "area": 2062641.0684959998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 14497, + "strid": "2df2a6e5-07b3-430c-bcac-56a24aa517c2", + "image_id": 201076, + "image_name": "11601.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1713.403, + 1955.761, + 1436.7519999999997, + 160.3739999999998 + ], + "priority": 14, + "parents": [ + 14487 + ], + "children": [], + "area": 3351006.764683, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3: CDD and SFLD profiles are annotated with residue\ninformation for specific amino acids important for function,\nbinding, etc." + }, + { + "id": 14491, + "strid": "8a04ef38-0d29-4507-ba73-e23ebf3d773d", + "image_id": 201076, + "image_name": "11601.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1719.829, + 2143.996, + 1428.043, + 629.2150000000001 + ], + "priority": 15, + "parents": [ + 14486 + ], + "children": [ + 14493 + ], + "area": 3687306.496684, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 14493, + "strid": "65215680-e4aa-4b84-b00e-0354f82e3ffd", + "image_id": 201076, + "image_name": "11601.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1708.038, + 2820.095, + 1443.4450000000002, + 177.70499999999993 + ], + "priority": 16, + "parents": [ + 14491 + ], + "children": [], + "area": 4816829.42361, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 4: When a sequence matches a relevant profile\nin InterProScan, the appropriate matching amino acids\nare highlighted in the output." + }, + { + "id": 14490, + "strid": "b9cccb90-ad5b-423f-a0ab-bec9e5d8e129", + "image_id": 201076, + "image_name": "11601.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1717.515, + 3032.54, + 1230.9690000000003, + 66.7829999999999 + ], + "priority": 17, + "parents": [ + 14479 + ], + "children": [ + 14494, + 14495 + ], + "area": 5208432.9381, + "iscrowd": 0, + "segmentation": [], + "text": "Intrinsically disordered protein regions" + }, + { + "id": 14495, + "strid": "d19cf5fc-8f08-48cb-a19c-0973aae9d151", + "image_id": 201076, + "image_name": "11601.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1710.264, + 3105.072, + 1477.077, + 600.2960000000003 + ], + "priority": 18, + "parents": [ + 14490 + ], + "children": [], + "area": 5310492.859008, + "iscrowd": 0, + "segmentation": [], + "text": "To complement the capability to annotate signal\npeptides, transmembrane regions and coiled-coils,\nInterPro has added prediction of intrinsically\ndisordered regions (IDRs) - polypeptide segments\nthat have little or no three-dimensional structure\n-through integration of MobiDB Lite. This tool\ncombines eight different prediction methods to\ngenerate consensus IDR annotations, focusing on\nlong disordered regions." + }, + { + "id": 14494, + "strid": "533ae38f-8ab7-41b7-9751-404412d6cf40", + "image_id": 201076, + "image_name": "11601.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1709.308, + 3715.425, + 1493.6279999999997, + 357.7550000000001 + ], + "priority": 19, + "parents": [ + 14490 + ], + "children": [ + 14489 + ], + "area": 6350805.6759, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 14489, + "strid": "16ff95e7-464b-4836-a9af-4ce8413de76e", + "image_id": 201076, + "image_name": "11601.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1730.884, + 4101.525, + 1489.373, + 268.64599999999973 + ], + "priority": 20, + "parents": [ + 14494 + ], + "children": [], + "area": 7099263.9980999995, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 5: Other sequence features in InterPro, including MobiDB\nLite IDR annotations for UniParc sequence UPI0003464803. IDRs\nhave a wide range of potential functions, from acting as flexible\nlinkers between domains, to interacting with other proteins and\nmodifying their activity." + }, + { + "id": 45712, + "strid": "7fc6a18e-89e2-467c-b10a-c1ecdb02c73e", + "image_id": 202286, + "image_name": "118480.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 31.9, + 57.75, + 107.26999999999998, + 221.25 + ], + "priority": -1, + "parents": [], + "children": [ + 45673, + 45679, + 45674, + 45675, + 45680, + 45677, + 45676, + 45678 + ], + "area": 1842.225, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 45673, + "strid": "5ad564fa-daec-4f0d-aa11-2c314e396378", + "image_id": 202286, + "image_name": "118480.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 283.744, + 35.998, + 1816.601, + 106.50400000000002 + ], + "priority": 1, + "parents": [ + 45712 + ], + "children": [], + "area": 10214.216512, + "iscrowd": 0, + "segmentation": [], + "text": "MORE EFFICIENP CARBOH YDRATE METABOLISM ACCOUNTS FOR HIGHER\nFERTILYTY OF ZEBU CATTLE (BoS indicus) INTROPICAL AREAS ~\\——,~" + }, + { + "id": 45674, + "strid": "93e2d6af-18eb-465d-b3de-8e3fb860b35a", + "image_id": 202286, + "image_name": "118480.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 184.98, + 165.246, + 1960.495, + 175.179 + ], + "priority": 2, + "parents": [ + 45712 + ], + "children": [], + "area": 30567.20508, + "iscrowd": 0, + "segmentation": [], + "text": "AlnAShrafzadeh!, Sheila Nathan!, Iekhsan Othman’, Tee Ting Yee? & Saiful Anuar Kargani*\n\n'School of Biosciences\"and=Biotechnology, Faculty of Science and Technology,{Unhiversiti Kebangsaan Malaysia, Selangor, Malaysiag*Scheol of Medicine and Health Scien\nMonash UniversitySunway Campus, Kuala Lumpur, Malaysia; *Institute ofsBidlogical Sciences, Faculty of Science, & University ofMalaya Centre for Proteomics Research,\nUniversity 6f&Malaya, Kuala Lumpur, Malaysia" + }, + { + "id": 45675, + "strid": "29e0e664-4ddf-43af-866b-334fae102b3d", + "image_id": 202286, + "image_name": "118480.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 204.674, + 434.634, + 185.23099999999997, + 27.182999999999993 + ], + "priority": 3, + "parents": [ + 45712 + ], + "children": [ + 45681 + ], + "area": 88958.279316, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 45681, + "strid": "6e41ffa6-c931-49a8-9635-c812f74e9922", + "image_id": 202286, + "image_name": "118480.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 22.84, + 482.218, + 543.668, + 690.9389999999999 + ], + "priority": 4, + "parents": [ + 45675 + ], + "children": [], + "area": 11013.859120000001, + "iscrowd": 0, + "segmentation": [], + "text": "Profitability of cattle farming is highly\ndependent on animal fertility. Heat stress\nis a major cause of cattle subfertility in\ntropical areas. Although European\nbreeds. and crossbreed of cattle have\nhigher production performance, they are\nmore susceptible to heat stress compared\nto zebu cattle (8). To uncover\nphysiological pathway/s associated with\nhigher fertility and heat tolerance of\nZebu cattle sperm, we attempted to\nintegrate metabolomics- and. proteomics-\nbased approaches to unravel\nphysiological differences. between sperm\nfrom the high fertile Malaysian\nindigenous breed, Kedah Kelantan (KK)\n(Bos indicus), compared to sperm from\nthe sub-fertile crossbreed of cattle,\nMafriwal (Bos taurus Bos indicus)." + }, + { + "id": 45676, + "strid": "f38b7840-f89d-41c3-aa25-6476e707f935", + "image_id": 202286, + "image_name": "118480.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 201.845, + 1201.406, + 191.066, + 33.98199999999997 + ], + "priority": 5, + "parents": [ + 45712 + ], + "children": [ + 45701, + 45704, + 45698, + 45700, + 45711, + 45710, + 45699, + 45708, + 45707, + 45702, + 45706, + 45697, + 45709, + 45705, + 45703 + ], + "area": 242497.79406999997, + "iscrowd": 0, + "segmentation": [], + "text": "Methodology" + }, + { + "id": 45697, + 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Significant higher abundance of\nglucose and over expression of glycolytic\nenzymes, aS a major source of energy\nproduction in mammalian sperm, can\nprovide greater energy supply for fast\nmoving sperm in KK and contribute to\nhigher fertility of this breed. 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ELIXIR Belgium will\nfocus on Data Management, Data-analysis platforms, Training and Node Services in the Plant Sciences, Proteomics\nand Human Data Communities." + }, + { + "id": 109753, + "strid": "6c87e326-fc10-43fc-9a7d-39f491b61d8d", + "image_id": 204757, + "image_name": "13003.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 308.554, + 1181.938, + 474.77599999999995, + 67.72499999999991 + ], + "priority": 4, + "parents": [ + 109758 + ], + "children": [], + "area": 364691.697652, + "iscrowd": 0, + "segmentation": [], + "text": "Core team" + }, + { + "id": 109755, + "strid": "2d4f25aa-a6f5-4015-87cb-5770031bd3ba", + "image_id": 204757, + "image_name": "13003.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 227.701, + 2613.81, + 1763.694, + 88.17399999999998 + ], + "priority": 5, + "parents": [ + 109758 + ], + "children": [ + 109750, + 109751 + ], + "area": 595167.15081, + "iscrowd": 0, + "segmentation": [], + "text": "Current Node Services 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"Author Info", + "bbox": [ + 1962.774, + 251.149, + 1682.5480000000002, + 119.86500000000001 + ], + "priority": 2, + "parents": [ + 190596 + ], + "children": [], + "area": 492948.727326, + "iscrowd": 0, + "segmentation": [], + "text": "Shaiyan Keshvari & Maarten Wijntjes" + }, + { + "id": 190577, + "strid": "81ab5648-e9fc-435e-a2b2-dd2365e54d9d", + "image_id": 207940, + "image_name": "9148.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 531.6, + 454.511, + 810.3650000000001, + 105.90199999999999 + ], + "priority": 3, + "parents": [ + 190596 + ], + "children": [ + 190587, + 190588, + 190584, + 190586, + 190585 + ], + "area": 241618.04760000002, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 190584, + "strid": "1d244716-2483-46f6-bb7f-4c141a7fc5e6", + "image_id": 207940, + "image_name": "9148.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 57.246, + 599.587, + 1779.268, + 750.387 + ], + "priority": 4, + "parents": [ + 190577 + ], + "children": [], + "area": 34323.957402, + "iscrowd": 0, + "segmentation": [], + "text": "Given a single image, humans can rapidly\nidentify a material and its properties. This\nability relies on various cues, including but not\nlimited to color, texture, shape, and gloss.\nHere, we study the contribution of texture,\nand how it might relate to peripheral\nperception of materials." + }, + { + "id": 190585, + "strid": "8179ca32-aa05-4014-842b-3aef1c0e65b3", + "image_id": 207940, + "image_name": "9148.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 101.724, + 1418.003, + 323.658, + 432.6980000000001 + ], + "priority": 5, + "parents": [ + 190577 + ], + "children": [ + 190593 + ], + "area": 144244.937172, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190593, + "strid": "8d7fb6b4-9bd7-45bd-8184-85f507211f3f", + "image_id": 207940, + "image_name": "9148.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 133.512, + 1870.364, + 261.43, + 134.15499999999997 + ], + "priority": 6, + "parents": [ + 190585 + ], + "children": [], + "area": 249716.038368, + "iscrowd": 0, + "segmentation": [], + "text": "Leaves, damp or\nsoggy, relatively\nsmall, slippery" + }, + { + "id": 190586, + "strid": "3335133a-4d70-43bf-bdd4-c06d3bb3ecc8", + "image_id": 207940, + "image_name": "9148.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 669.009, + 1418.003, + 427.2750000000001, + 316.2439999999999 + ], + "priority": 7, + "parents": [ + 190577 + ], + "children": [ + 190594 + ], + "area": 948656.769027, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190594, + "strid": "b55d2635-8f65-4fa7-8289-c2092dbc598a", + "image_id": 207940, + "image_name": "9148.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 682.17, + 1749.109, + 395.58399999999995, + 135.01499999999987 + ], + "priority": 8, + "parents": [ + 190586 + ], + "children": [], + "area": 1193189.6865299998, + "iscrowd": 0, + "segmentation": [], + "text": "Stone, dry, rough, dense,\nhard, ambiguous size,\npossibly cut by people" + }, + { + "id": 190587, + "strid": "f5724a5e-db81-4f3a-bd65-3626521c6b0a", + "image_id": 207940, + "image_name": "9148.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1343.657, + 1412.906, + 424.69499999999994, + 317.35300000000007 + ], + "priority": 9, + "parents": [ + 190577 + ], + "children": [ + 190595 + ], + "area": 1898461.0372419998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190595, + "strid": "dfafede0-4880-4410-8aa2-d098f66123da", + "image_id": 207940, + "image_name": "9148.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1354.663, + 1749.109, + 400.74400000000014, + 92.01600000000008 + ], + "priority": 10, + "parents": [ + 190587 + ], + "children": [], + "area": 2369453.245267, + "iscrowd": 0, + "segmentation": [], + "text": "Water, wet, middle-sized,\nclear, wavy, contains fish" + }, + { + "id": 190588, + "strid": "b8206501-649a-4b64-b3aa-243e9c49cbe3", + "image_id": 207940, + "image_name": "9148.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 541.836, + 1958.354, + 1151.182, + 53.25199999999995 + ], + "priority": 11, + "parents": [ + 190577 + ], + "children": [], + "area": 1061106.6979440001, + "iscrowd": 0, + "segmentation": [], + "text": "From the Flickr Materials Database (FMD) (Sharan et al., 2014)" + }, + { + "id": 190578, + "strid": "e5f9ef60-9682-4e1a-af7f-5ba179cc107d", + "image_id": 207940, + "image_name": "9148.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 433.605, + 2048.534, + 1006.9659999999999, + 108.91300000000001 + ], + "priority": 12, + "parents": [ + 190596 + ], + "children": [ + 190568 + ], + "area": 888254.58507, + "iscrowd": 0, + "segmentation": [], + "text": "Research questions:" + }, + { + "id": 190568, + "strid": "566bf003-5b60-4fd1-ac17-9154409f031e", + "image_id": 207940, + "image_name": "9148.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 30.841, + 2192.573, + 1807.633, + 415.163 + ], + "priority": 13, + "parents": [ + 190578 + ], + "children": [], + "area": 67621.143893, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190579, + "strid": "0b83cdbb-d2f9-4771-aa0e-0487e0450383", + "image_id": 207940, + "image_name": "9148.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 683.756, + 2657.488, + 528.284, + 107.97200000000021 + ], + "priority": 14, + "parents": [ + 190596 + ], + "children": [ + 190583, + 190569 + ], + "area": 1817073.364928, + "iscrowd": 0, + "segmentation": [], + "text": "Approach:" + }, + { + "id": 190569, + "strid": "aadc86ff-65ab-426f-a020-5d949b38e315", + "image_id": 207940, + "image_name": "9148.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 38.577, + 2795.977, + 1768.953, + 992.7799999999997 + ], + "priority": 15, + "parents": [ + 190579 + ], + "children": [], + "area": 107860.40472899999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190583, + "strid": "49486568-59db-4376-8942-5b6ed5169c04", + "image_id": 207940, + "image_name": "9148.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 83.52, + 3814.313, + 1722.082, + 343.2049999999999 + ], + "priority": 16, + "parents": [ + 190579 + ], + "children": [], + "area": 318571.42176, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190576, + "strid": "cecc4136-6322-4a11-b7c1-db57838908fd", + "image_id": 207940, + "image_name": "9148.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2452.823, + 455.859, + 728.0419999999999, + 111.90299999999996 + ], + "priority": 17, + "parents": [ + 190596 + ], + "children": [ + 190572, + 190590, + 190589, + 190591, + 190571, + 190592 + ], + "area": 1118141.4399569998, + "iscrowd": 0, + "segmentation": [], + "text": "EXPERIMENTS" + }, + { + "id": 190571, + "strid": "4bf2b349-a760-4901-905d-a994e97cea57", + "image_id": 207940, + "image_name": "9148.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1930.621, + 589.145, + 1760.761, + 331.102 + ], + "priority": 18, + "parents": [ + 190576 + ], + "children": [], + "area": 1137415.709045, + 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"bff6186d-d2bd-4835-80b2-1d92567e1e99", + "image_id": 207940, + "image_name": "9148.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4453.592, + 455.859, + 453.0039999999999, + 103.81400000000002 + ], + "priority": 24, + "parents": [ + 190596 + ], + "children": [ + 190582, + 190570 + ], + "area": 2030209.9955279997, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 190570, + "strid": "c293f383-07ea-4702-933b-5a9bc47bd28f", + "image_id": 207940, + "image_name": "9148.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3792.247, + 586.952, + 1760.761, + 324.524 + ], + "priority": 25, + "parents": [ + 190575 + ], + "children": [], + "area": 2225866.961144, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190582, + "strid": "01b40fc7-fe5b-43cf-95ea-2fe697bbdc0d", + "image_id": 207940, + "image_name": "9148.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3713.33, + 962.128, + 1869.8580000000002, + 2674.371 + ], + "priority": 26, + "parents": [ + 190575 + ], + "children": [], + "area": 3572698.7662400003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190580, + "strid": "4a09f46e-7c78-42b7-91f2-17fae3679fbd", + "image_id": 207940, + "image_name": "9148.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4317.061, + 3663.145, + 759.2569999999996, + 108.89300000000003 + ], + "priority": 27, + "parents": [ + 190596 + ], + "children": [ + 190581 + ], + "area": 15814020.416845, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 190581, + "strid": "ac931497-871a-435f-9c02-198363b44b78", + "image_id": 207940, + "image_name": "9148.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3787.133, + 3808.003, + 1782.701, + 321.9069999999997 + ], + "priority": 28, + "parents": [ + 190580 + ], + "children": [], + "area": 14421413.825399, + "iscrowd": 0, + "segmentation": [], + "text": "Texture captures some fraction of performance\nPeripheral is correlated with texture, perhaps\ndue to sharing a statistical representation" + }, + { + "id": 12776, + "strid": "d8774b1e-5d86-4338-b7d9-a0b55fb3a36f", + "image_id": 201017, + "image_name": "11463.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 31.7, + 218.07, + 113.67999999999999, + 109.75999999999999 + ], + "priority": -1, + "parents": [], + "children": [ + 12777, + 12795, + 12783, + 12786, + 12794, + 12791, + 12792, + 12778, + 12781, + 12782, + 12788, + 12779, + 12789, + 12790, + 12796, + 12793, + 12785 + ], + "area": 6912.8189999999995, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 12777, + "strid": "264fe459-68d6-4d5d-b5d4-4bd1cc048691", + "image_id": 201017, + "image_name": "11463.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 79.236, + 38.38, + 1633.716, + 163.495 + ], + "priority": 1, + "parents": [ + 12776 + ], + "children": [], + "area": 3041.0776800000003, + "iscrowd": 0, + "segmentation": [], + "text": "Characterizing the structure of plant interaction\nnetworks ©" + }, + { + "id": 12778, + "strid": "29d9a1ed-fe6b-4b1f-9b22-01aa5b95b219", + "image_id": 201017, + "image_name": "11463.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 177.086, + 215.501, + 1445.448, + 106.52000000000001 + ], + "priority": 2, + "parents": [ + 12776 + ], + "children": [], + "area": 38162.21008600001, + "iscrowd": 0, + "segmentation": [], + "text": "~~ Nicole L. PRIS itch» y\nrtment of Ecology’& goa Na ge) / EN Se?" + }, + { + "id": 12779, + "strid": "ab26d6da-76b0-4554-a6e2-9be217641566", + "image_id": 201017, + "image_name": "11463.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 48.639, + 367.073, + 811.282, + 285.409 + ], + "priority": 3, + "parents": [ + 12776 + ], + "children": [], + "area": 17854.063647, + "iscrowd": 0, + "segmentation": [], + "text": "Plant ecology has a rich history of plant interaction experiments to\nmeasure how plants interact in plant communities based on\nperformance in pairwise species combinations. We propose\nrepresenting these plant communities as networks of competitive\nand facilitative interactions. This is a powerful approach that allows\none to characterize community structure quantitatively using\nnetwork metrics including asymmetry, transitivity, and connectance.\nWe also have developed a novel methodology for synthesizing the\nstructure of multiple networks using meta-analysis." + }, + { + "id": 12781, + "strid": "4c77d628-e7c6-4607-ad85-7ab2bdccc362", + "image_id": 201017, + "image_name": "11463.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 49.591, + 661.641, + 813.313, + 190.837 + ], + "priority": 4, + "parents": [ + 12776 + ], + "children": [], + "area": 32811.438831, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 12786, + "strid": "09f05117-e2a9-458d-8534-69f381e66c1a", + "image_id": 201017, + "image_name": "11463.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 47.863, + 866.873, + 813.443, + 190.462 + ], + "priority": 5, + "parents": [ + 12776 + ], + "children": [], + "area": 41491.142399000004, + "iscrowd": 0, + "segmentation": [], + "text": "Plant interaction experiments involve planting inter- or intraspecific combinations of species and\nMeasuring interaction strength using an index, e.g., Relative Interaction Intensity (RII) (2). The Rls for all\npairwise interactions in a community can be represented as a network (Fig. 1). As an example, we\nconducted a garden experiment to quantify interactions among woody plants in an old field community.\nThe results of this field experiment were included as one of the networks in the meta-analysis (Fig. 2).\n\nWe conducted a systematic review and identified 2,032 studies on Web of Science of which 31 met\nour selection criteria for inclusion in the meta-analysis. From each study, we built networks based on" + }, + { + "id": 12789, + "strid": "54fda6fc-6e2c-4464-b305-ae14ebabfbe7", + "image_id": 201017, + "image_name": "11463.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 47.99, + 1078.608, + 803.742, + 143.5530000000001 + ], + "priority": 6, + "parents": [ + 12776 + ], + "children": [], + "area": 51762.39792, + "iscrowd": 0, + "segmentation": [], + "text": "Interactions are competitive on average, but some networks are\nweakly facilitative.\n\nInteractions were hypothesized to be mostly competitive, as plants share similar resource requirements.\nThe effect size we used was the mean strength, i.e., the sum of the interactions (Rlls) directed towards or\naway from a species, for each network." + }, + { + "id": 12788, + "strid": "c6e54c33-ce9e-47d6-b3fb-6f9e3907af50", + "image_id": 201017, + "image_name": "11463.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 44.603, + 1223.029, + 812.313, + 296.13300000000004 + ], + "priority": 7, + "parents": [ + 12776 + ], + "children": [ + 12787 + ], + "area": 54550.762487, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 12787, + "strid": "973279fd-5a15-43b4-a65f-5c55a433691c", + "image_id": 201017, + "image_name": "11463.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 49.362, + 1519.98, + 800.344, + 31.286000000000058 + ], + "priority": 8, + "parents": [ + 12788 + ], + "children": [], + "area": 75029.25276, + "iscrowd": 0, + "segmentation": [], + "text": "Figs. 3-6. Points represent mean values. On left, forest plots of study-specific metrics. Error bars are +1 SE. On right, grand means for metrics\nacross studies, including grand mean and groupwise means. Error bars are 95% credible intervals." + }, + { + "id": 12793, + "strid": "519ff4bd-4526-47d2-9627-4d78955dc73f", + "image_id": 201017, + "image_name": "11463.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 46.099, + 1566.361, + 833.229, + 142.231 + ], + "priority": 9, + "parents": [ + 12776 + ], + "children": [], + "area": 72207.675739, + "iscrowd": 0, + "segmentation": [], + "text": "Transitivity is the norm, but intransitivity does exist in plant networks.\nTransitivity is prevalent in individual plant communities, though transitive communities are theoretically\nunstable. Most networks were transitive, but studies with a true control treatment were often strongly\n\nintransitive. The effect size used was the Relative Intransitivity (RI) index (4), where a completely transitive\ncommunity has an RI of 0 and a maximally intransitive community has an RI of 1." + }, + { + "id": 12792, + "strid": "172a6812-5099-41f1-81a5-6df6f8ff77ec", + "image_id": 201017, + "image_name": "11463.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 42.065, + 1732.663, + 813.558, + 298.21399999999994 + ], + "priority": 10, + "parents": [ + 12776 + ], + "children": [], + "area": 72884.469095, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 12783, + "strid": "4a70c103-243e-43c2-9f8f-47e67a37e5b7", + "image_id": 201017, + "image_name": "11463.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 917.467, + 367.009, + 816.322, + 221.86900000000003 + ], + "priority": 11, + "parents": [ + 12776 + ], + "children": [], + "area": 336718.646203, + "iscrowd": 0, + "segmentation": [], + "text": "matrices of mean/SD Ril (one per study), and calculated mean/SD for each network metric of interest.\n\nThese network metrics, including mean strength, asymmetry, transitivity, and connectance, were\nused as the effect sizes in the study, and were then synthesized across studies using a Bayesian random\neffects meta-analysis to calculate the grand mean of each metric weighted by the variation within each\ncommunity. Groupwise meta-analyses were also fit to understand the influence of experiment type (true\ncontrol/monoculture control), habitat (old fields/other habitats), and experimental setting (greenhouse,\ngarden, or field) on network structure.\n\nGarden experiment: a plant interaction network of an old field shrub community" + }, + { + "id": 12785, + "strid": "7f02ae63-b475-479b-af9a-e4a8b482d158", + "image_id": 201017, + "image_name": "11463.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 912.403, + 589.508, + 515.961, + 473.106 + ], + "priority": 12, + "parents": [ + 12776 + ], + "children": [ + 12780 + ], + "area": 537868.867724, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 12780, + "strid": "fe26710c-3e4d-481d-b611-77a93211fa02", + "image_id": 201017, + "image_name": "11463.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1429.858, + 874.878, + 312.548, + 89.69100000000003 + ], + "priority": 13, + "parents": [ + 12785 + ], + "children": [], + "area": 1250951.307324, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 1 (left). Old field plant interaction network based\non fieldwork at Yale-Myers Forest, CT in summer 2016.\nEdge width is proportional to edge weight. Edge\nweight isthe Ril for each pairwise species combination\n(legend represents Ril range). Competitive interactions\nare red, facilitative are blue." + }, + { + "id": 12782, + "strid": "d45ea27e-182e-424a-9697-53f4ebe93266", + "image_id": 201017, + "image_name": "11463.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1487.58, + 591.4, + 211.85500000000002, + 281.788 + ], + "priority": 14, + "parents": [ + 12776 + ], + "children": [ + 12784 + ], + "area": 879754.8119999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 12784, + "strid": "0837c094-30e4-4a93-8dc7-bec5a38f3c5c", + "image_id": 201017, + "image_name": "11463.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1429.858, + 972.794, + 316.0730000000001, + 86.16600000000005 + ], + "priority": 15, + "parents": [ + 12782 + ], + "children": [], + "area": 1390957.2832519999, + "iscrowd": 0, + "segmentation": [], + "text": "ig. 2 (above). Set-up for pairwise plant interaction\nexperiments at Yale-Myers Forest. Target individuals are\nsurrounded by four neighbor individuals in intra- and\ninterspecific pairwise species combinations. Targets\nwere harvested Aug. 2016 and biomass was used to\ncalculate Ril indices for the network." + }, + { + "id": 12791, + "strid": "5dd191de-f2ff-4a2a-b9ed-edd7acb70ec6", + "image_id": 201017, + "image_name": "11463.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 918.038, + 1079.901, + 825.8510000000001, + 143.93599999999992 + ], + "priority": 16, + "parents": [ + 12776 + ], + "children": [], + "area": 991390.154238, + "iscrowd": 0, + "segmentation": [], + "text": "Asymmetric interactions are not ubiquitous.\n\nAsymmetry occurs when one species has a strong effect on the other with little reciprocal effect. Asymmetry\nwould be expected to be prevalent as initial differences in resource capture ability generate a positive\nfeedback (3). The effect size calculated was the correlation coefficient between interaction weights w; and\nw;. Interactions were weakly asymmetric on average, but this varied greatly among communities." + }, + { + "id": 12790, + "strid": "8e6489b1-1f19-4806-a5b0-fda107df7cf6", + "image_id": 201017, + "image_name": "11463.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 922.903, + 1225.054, + 805.9280000000001, + 298.74199999999996 + ], + "priority": 17, + "parents": [ + 12776 + ], + "children": [], + "area": 1130606.0117620002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 12795, + "strid": "e36894af-b3e4-42dc-a4de-e1ee9d2c1ce7", + "image_id": 201017, + "image_name": "11463.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 917.416, + 1564.324, + 812.619, + 167.24299999999994 + ], + "priority": 18, + "parents": [ + 12776 + ], + "children": [], + "area": 1435135.866784, + "iscrowd": 0, + "segmentation": [], + "text": "Plant communities are strongly connected.\n\nConnectance describes how strongly members interact with one another compared to a maximum level.\nCommunities varied in their connectance, but it was very high on average. We predicted plant networks\nwould have higher connectance than other ecological networks (which tend to fall in the range of 0.03 to\n0.3) (5), as co-occurring plants should interact strongly with one another. The effect size for connectance\nwas weighted quantitative connectance (6)." + }, + { + "id": 12794, + "strid": "e61acb75-3058-498d-8a49-fb6c640e42d1", + "image_id": 201017, + "image_name": "11463.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 924.324, + 1734.444, + 806.429, + 294.3710000000001 + ], + "priority": 19, + "parents": [ + 12776 + ], + "children": [], + "area": 1603188.2158559998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 12796, + "strid": "3c1d093a-4549-4c25-8502-d798f19b8f46", + "image_id": 201017, + "image_name": "11463.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 48.011, + 2045.595, + 1668.806, + 162.9219999999998 + ], + "priority": 20, + "parents": [ + 12776 + ], + "children": [], + "area": 98211.061545, + "iscrowd": 0, + "segmentation": [], + "text": "By synthesizing structural metrics of multiple plant interaction communities using meta-analysis, we were able to make broad, quantitative\ngeneralizations about the nature of interactions in plant communities. Plant interaction networks are dominated by competitive interactions\nand are highly connected relative to other ecological networks. Interactions are not necessarily asymmetric, and intransitivity, or breaking\nfrom a hierarchy, is a feature of many communities. Network metrics differ based on whether the study had a true control treatment, but do\nnot differ based on the habitat or experimental setting of the study." + }, + { + "id": 150883, + "strid": "410fdf23-42e3-4e1e-8041-06db45327aea", + "image_id": 206365, + "image_name": "21084.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 40.69, + 124.31, + 128.78, + 208.02999999999997 + ], + "priority": -1, + "parents": [], + "children": [ + 150872, + 150874, + 150873, + 150876, + 150875, + 150877 + ], + "area": 5058.1739, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 150872, + "strid": "b3a1b162-b97a-44fd-9c79-0c402e052696", + "image_id": 206365, + "image_name": "21084.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 234.369, + 102.09, + 2371.926, + 331.08899999999994 + ], + "priority": 1, + "parents": [ + 150883 + ], + "children": [], + "area": 23926.73121, + "iscrowd": 0, + "segmentation": [], + "text": "Content Analysis of Institutional Policies\n\non Open Science: Brazil, France, Peru, UK" + }, + { + "id": 150873, + "strid": "6dc29e71-0259-45bd-a0c6-b9edd1e71802", + "image_id": 206365, + "image_name": "21084.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 107.915, + 570.66, + 728.531, + 92.74300000000005 + ], + "priority": 2, + "parents": [ + 150883 + ], + "children": [], + "area": 61582.7739, + "iscrowd": 0, + "segmentation": [], + "text": "Alejandra Manco" + }, + { + "id": 150874, + "strid": "3f1ca8ec-aa72-4914-a266-ec5b0557eddd", + "image_id": 206365, + "image_name": "21084.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 102.951, + 845.754, + 605.486, + 80.26200000000006 + ], + "priority": 3, + "parents": [ + 150883 + ], + "children": [ + 150879 + ], + "area": 87071.22005399999, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 150879, + "strid": "ddd75028-8f54-45b9-972f-af8ce8738242", + "image_id": 206365, + "image_name": "21084.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 91.603, + 1022.718, + 1229.834, + 473.62 + ], + "priority": 4, + "parents": [ + 150874 + ], + "children": [], + "area": 93684.036954, + "iscrowd": 0, + "segmentation": [], + "text": "Open science is gaining traction worldwide, with\nopen science policies being enacted at institutional,\nnational, regional, and international levels.\n\nDuring the last ten years, many institutions have\nbegun to design, adopt, and implement open\nscience policies (Schmidt et al., 2018)\n\n(Kretser et al., 2019)." + }, + { + "id": 150875, + "strid": "3b93ac18-9646-4006-a2ad-a510a59e84e1", + "image_id": 206365, + "image_name": "21084.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 95.756, + 1585.553, + 368.10900000000004, + 83.84699999999998 + ], + "priority": 5, + "parents": [ + 150883 + ], + "children": [ + 150878 + ], + "area": 151826.213068, + "iscrowd": 0, + "segmentation": [], + "text": "Method" + }, + { + "id": 150878, + "strid": "7e8a2b17-92c6-41c5-a1f0-e71c5ee97ff9", + "image_id": 206365, + "image_name": "21084.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 105.877, + 1786.66, + 1199.283, + 821.876 + ], + "priority": 6, + "parents": [ + 150875 + ], + "children": [], + "area": 189166.20082, + "iscrowd": 0, + "segmentation": [], + "text": "Qualitative document analysis (Bowen, 2009)\n(Cardno, 2018).\n\n1. Top 20 universities of QS World University\nRanking 2082 in each of the 4 countries.\n\na. For each university, we searched to\n\nfind an open science policy. Search 1: search\ngoogle using [University name] AND open science\npolicy. Search 2: Go to the university's website\nand search [open science policy].\n\nA total of 31 documents were retrieved after\nthe search process. 16 from France, 14 from\nthe UK, 1 from Brazil, 0 from Peru.\n\nInductive thematic categorization - Nvivo 12." + }, + { + "id": 150876, + "strid": "de829176-2140-4c93-84b2-deb15c3c8092", + "image_id": 206365, + "image_name": "21084.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 94.305, + 2753.167, + 352.431, + 86.25900000000001 + ], + "priority": 7, + "parents": [ + 150883 + ], + "children": [ + 150880, + 150882 + ], + "area": 259637.41393500002, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 150882, + "strid": "f81c933b-8cf9-491a-8972-347ee207a344", + "image_id": 206365, + "image_name": "21084.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 91.594, + 2909.736, + 1220.632, + 1181.6999999999998 + ], + "priority": 8, + "parents": [ + 150876 + ], + "children": [], + "area": 266514.35918399994, + "iscrowd": 0, + "segmentation": [], + "text": "OS definitions opening research outputs. Often\nintertwined with a transparency in science claim.\n\nDifferent strategies changes in the evaluation\nelements for research assessment, enhancing\ninternal communication and collaboration, Ph.D.\nstudents training in open science, offering support\nto researchers, and skills development and\n\ntraining in software.\n\nOS components emphasized are open access and\nopen research data. Only very seldomly other\ncomponents are also stated.\n\nInstitutional open science policies address the\nresearcher's career as responsible research\nassessment.\n\nHowever, this issue is primarily discussed in\nFrench documents." + }, + { + "id": 150880, + "strid": "3f690c00-03a8-4d04-b0a0-ab41a318350f", + "image_id": 206365, + "image_name": "21084.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1395.154, + 833.671, + 1334.8650000000002, + 1416.849 + ], + "priority": 9, + "parents": [ + 150876 + ], + "children": [], + "area": 1163099.4303340001, + "iscrowd": 0, + "segmentation": [], + "text": "Policy intertextuality Declarations: France - Jussieu\nCall for Open science and bibliodiversity.\n\nUK & Brazil - San Francisco Declaration on Research\nAssessment (DORA). Brazil - UNESCO\nrecommendations on open science & UN’s 2030\nAgenda for Sustainable Development.\n\nNational references: France: Law for the\n\nDigital Republic of 2016. CNRS roadmap for open\nscience. National Plan for Open Science.\n\nRelations to other issues No specific mention of\nscience policy. Brazilian open science declaration -\nequity, diversity, and inclusion as inherent to open\nscience, social impact of science, and development.\nThe policies do not discuss further economic and\npolitical contexts.\n\nInternal communication: researchers & academic\ncommunity. However, the subject of the general public\n-society overall- is related to the idea of making science\naccessible to all and not specifically to public science\ncommunication." + }, + { + "id": 150877, + "strid": "bb59106f-986e-4c90-bb28-601b81921e57", + "image_id": 206365, + "image_name": "21084.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1400.293, + 2378.109, + 716.037, + 211.00599999999986 + ], + "priority": 10, + "parents": [ + 150883 + ], + "children": [ + 150881 + ], + "area": 3330049.3859369997, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion and\nConclusions" + }, + { + "id": 150881, + "strid": "1f48298b-339e-4c6a-8194-e0296c0c7e5b", + "image_id": 206365, + "image_name": "21084.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1391.083, + 2660.535, + 1339.5970000000002, + 813.105 + ], + "priority": 11, + "parents": [ + 150877 + ], + "children": [], + "area": 3701025.009405, + "iscrowd": 0, + "segmentation": [], + "text": "Open science is defined as opening research outputs in\nthe different institutional policies.\n\nBrazilian institution's declaration on open science\nrelates to the international organizations reference.\nFrance: interest in open science is a strategic goal for\nthe government through a top-down policy approach\n(Méndez, 2021) to which the different institutional\nopen science policies are aligned.\n\nAbsence of policies in the South American may indicate\nthat even though the subject of open science is\nextensively discussed, it is still not materialized in\naction." + }, + { + "id": 48272, + "strid": "e0098738-3ef1-45f6-90d1-5732da791121", + "image_id": 202390, + "image_name": "118635.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 57.51, + 260.48, + 280.96000000000004, + 229.88 + ], + "priority": -1, + "parents": [], + "children": [ + 48265, + 48267, + 48269, + 48271, + 48257, + 48258, + 48255, + 48266, + 48256, + 48268, + 48270 + ], + "area": 14980.204800000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 48255, + "strid": "93f57661-7b6a-41a7-977c-0cf4e14be50a", + "image_id": 202390, + "image_name": "118635.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 585.585, + 66.279, + 2367.45, + 351.695 + ], + "priority": 1, + "parents": [ + 48272 + ], + "children": [], + "area": 38811.988215, + "iscrowd": 0, + "segmentation": [], + "text": "Tristoma pintodiasi (Hemiptera: Reduviidae:\n\n: . : : Rae\nriatominae), new cryptic species vector of the\n‘Chagas’ disease from southern South America" + }, + { + "id": 48256, + "strid": "307caff6-b2a4-406f-8d96-5b8d5f97fbd6", + "image_id": 202390, + "image_name": "118635.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 584.106, + 537.807, + 2375.08, + 153.26599999999996 + ], + "priority": 2, + "parents": [ + 48272 + ], + "children": [], + "area": 314136.295542, + "iscrowd": 0, + "segmentation": [], + "text": "José Jurberg, oe Solange Cailleaux, Raquel Raigorodschi, Michele\nSouza Lima, Dayse da Silva Rocha, Felip Ferraz Figueiredo Moreira" + }, + { + "id": 48257, + "strid": "4dd25ca1-a624-4ca3-9ac3-dc3984d297df", + "image_id": 202390, + "image_name": "118635.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 40.102, + 760.818, + 3468.414, + 241.61699999999996 + ], + "priority": 3, + "parents": [ + 48272 + ], + "children": [], + "area": 30510.323435999995, + "iscrowd": 0, + "segmentation": [], + "text": "Cc is’ disease continues being ee for the poor population fiom 21 countries in America, wher 100 million people live under oe\nana about 8 million might be ne with a still incurable illness . 1). During a field trip in searcr: of vectors of Chagas’ disease e\nlocality of Rincao Nossa Senhora as Gracas, Cacgapava do Su icipality, Rio Grande do Sul Stave, Brazil (30°30’58” S / 53°29'12” W),\n14 specimens of triatomines have been collected on a stone fence (Figs. 2-3). - as" + }, + { + "id": 48265, + "strid": "55e17bac-4d5c-4c9e-8017-6d816dec33e1", + "image_id": 202390, + "image_name": "118635.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 41.674, + 1021.675, + 704.284, + 878.3109999999999 + ], + "priority": 4, + "parents": [ + 48272 + ], + "children": [ + 48259 + ], + "area": 42577.28395, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 48259, + "strid": "64413fa8-c5fa-41f7-84b8-84b5edaef46a", + "image_id": 202390, + "image_name": "118635.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2929.531, + 1078.879, + 584.0, + 239.80299999999988 + ], + "priority": 5, + "parents": [ + 48265 + ], + "children": [], + "area": 3160609.4757489995, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 1. Map of Latin\nNig showing the\nen ic zones- of\n\ngas’ disease." + }, + { + "id": 48266, + "strid": "7b1077b2-53a5-467d-bd67-3753f7e32a1d", + "image_id": 202390, + "image_name": "118635.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 767.824, + 1020.118, + 1008.0670000000001, + 877.2989999999999 + ], + "priority": 6, + "parents": [ + 48272 + ], + "children": [ + 48260 + ], + "area": 783271.083232, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 48260, + "strid": "e9e74e48-d8e3-4ad4-bf9d-c3b5c99bc36a", + "image_id": 202390, + "image_name": "118635.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2927.758, + 1498.566, + 579.8110000000001, + 350.9860000000001 + ], + "priority": 7, + "parents": [ + 48266 + ], + "children": [], + "area": 4387438.595028, + "iscrowd": 0, + "segmentation": [], + "text": "Figs 2-3. Keymaps\nshowing the _ tvpe\nlocality of Tria tana\npintodiasi\nGrande do s <\nBrazil." + }, + { + "id": 48267, + "strid": "6bcaf1cb-0490-4ca9-9b62-be9268ad9b83", + "image_id": 202390, + "image_name": "118635.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1789.925, + 1021.212, + 1126.0419999999997, + 879.72 + ], + "priority": 8, + "parents": [ + 48272 + ], + "children": [], + "area": 1827892.8891, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 48258, + "strid": "b82df5fb-2ca5-4771-8541-add5d9437c92", + "image_id": 202390, + "image_name": "118635.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 34.573, + 1921.593, + 3477.726, + 421.57399999999984 + ], + "priority": 9, + "parents": [ + 48272 + ], + "children": [], + "area": 66435.23478900001, + "iscrowd": 0, + "segmentation": [], + "text": "The general coloration of the insects (Fig. 5) is striking'y similar to that of Triatoma carczavalloi (Fig. 6), but they show inctly smaller\nsize. The same specimens result in T. Seen GGUS (Fig. 4) on available keys, it do not fit on the chromati an morphological\nstandards of th ‘species. After comparison wi e types of both similar species, it was possible to determiiie the material as\nrepresentative a new cryptic species of the T. rovaria subcomplex. Beside ne description of the general c nd morphology and\nof male geni cla, morphometric analysis of ee of Triatoma pintodiasi, T. rovaria, T. carcavalloi, and ES) cummaculata (Fig. 7),\nand an analysis of the hemolymph proteins c riatoma pintodiasi and T. circxinmaculata (Figs. 8-9) have er; made in order to provide\nsubstantia! support for the new species. oO" + }, + { + "id": 48268, + "strid": "1fbf6c32-885e-4de7-9527-512d97562f63", + "image_id": 202390, + "image_name": "118635.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 39.198, + 2353.949, + 1478.191, + 785.5410000000002 + ], + "priority": 10, + "parents": [ + 48272 + ], + "children": [ + 48261 + ], + "area": 92270.092902, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 48261, + "strid": "ad8ba827-576e-48d4-90a9-311ef8d039d7", + "image_id": 202390, + "image_name": "118635.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2711.959, + 2358.903, + 798.7260000000001, + 302.13200000000006 + ], + "priority": 11, + "parents": [ + 48268 + ], + "children": [], + "area": 6397248.220976999, + "iscrowd": 0, + "segmentation": [], + "text": "Figs. 4-6. Comparative view\nbetween\n\nspecimens\nTriatoma_ circummaculat »;\nT. pintodiasi (5), T.\n\ncarcavalloi (6). ae" + }, + { + "id": 48269, + "strid": "49451a9b-0ddc-495d-a8d1-2bce56768a53", + "image_id": 202390, + "image_name": "118635.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1526.919, + 2356.008, + 1171.352, + 787.0340000000001 + ], + "priority": 12, + "parents": [ + 48272 + ], + "children": [ + 48262 + ], + "area": 3597433.379352, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 48262, + "strid": "02aad6dd-ad41-49cb-8fca-28b2e61cf345", + "image_id": 202390, + "image_name": "118635.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2712.873, + 2778.66, + 796.8009999999999, + 352.721 + ], + "priority": 13, + "parents": [ + 48269 + ], + "children": [], + "area": 7538151.69018, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 7. Anal of principal\ncomponents obtained _ by\nmorpho Cc analysis of the\nheads of ‘Triatoma pintodiasi, T.\ncircuinmaculata, T. rubrovaria,\na . carcavalloi." + }, + { + "id": 48270, + "strid": "ad00d854-afd4-4446-909a-c595c1486e00", + "image_id": 202390, + "image_name": "118635.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 49.139, + 3169.631, + 818.903, + 741.4859999999999 + ], + "priority": 14, + "parents": [ + 48272 + ], + "children": [ + 48263 + ], + "area": 155752.497709, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 48263, + "strid": "1f68c496-d619-474f-919f-6b51c5e63024", + "image_id": 202390, + "image_name": "118635.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2020.045, + 3227.666, + 1487.7640000000001, + 245.2800000000002 + ], + "priority": 15, + "parents": [ + 48270 + ], + "children": [], + "area": 6520030.564970001, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 8. A - Standards nolecular weight 250 KDa, 1\nKDa, 98 KDa, 64 Kral © KDa, 36 KDa, 6 KDa, and 4 .\nB - Analysis of the olymph of T. circummaculate. C -\nAnalysis of the he:nolymph of T. pintodiasi.\n\nLl." + }, + { + "id": 48271, + "strid": "29656951-9b59-40d2-8b29-66c220a4c755", + "image_id": 202390, + "image_name": "118635.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 923.914, + 3174.218, + 1071.145, + 737.308 + ], + "priority": 16, + "parents": [ + 48272 + ], + "children": [ + 48264 + ], + "area": 2932704.4492519996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 48264, + "strid": "3cdc5a0b-82bd-4099-9f48-2d9766de0b6e", + "image_id": 202390, + "image_name": "118635.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2020.982, + 3648.529, + 1489.5079999999998, + 235.08899999999994 + ], + "priority": 17, + "parents": [ + 48271 + ], + "children": [], + "area": 7373611.435478, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 9. Densitometry of the eletrophoressis gel bands of T.\n\ncir aculata and T. Sines cferenes indicate\n\nmalecular weights to which alloy difference has been\nnd." + }, + { + "id": 21277, + "strid": "376fdba6-1008-4898-b4ab-23c5c367be4d", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 30.69, + 26.08, + 104.83000000000001, + 42.879999999999995 + ], + "priority": -1, + "parents": [], + "children": [ + 21290, + 21280, + 21278, + 21287, + 21293, + 21281, + 21279, + 21284 + ], + "area": 800.3951999999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 21278, + "strid": "1556c1af-700a-4fbe-ada1-859dec7bea8a", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 78.519, + 86.198, + 977.1090000000002, + 218.61400000000003 + ], + "priority": 1, + "parents": [ + 21277 + ], + "children": [], + "area": 6768.180762, + "iscrowd": 0, + "segmentation": [], + "text": "Assessing searches in NICE\nSingle Technology Appraisals:\npractice and checklist" + }, + { + "id": 21279, + "strid": "0fb23adc-3b28-480f-9364-4f0afd967eaf", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 66.611, + 389.609, + 821.466, + 72.81900000000002 + ], + "priority": 2, + "parents": [ + 21277 + ], + "children": [], + "area": 25952.245099, + "iscrowd": 0, + "segmentation": [], + "text": "Ruth Wong, Suzy Paisley and Christopher Carroll\nScHARR, University of Sheffield, UK" + }, + { + "id": 21280, + "strid": "e04b769d-f0df-4a1c-95c9-55ab58155286", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 96.483, + 592.519, + 377.935, + 255.72800000000007 + ], + "priority": 3, + "parents": [ + 21277 + ], + "children": [], + "area": 57168.010677000006, + "iscrowd": 0, + "segmentation": [], + "text": "1. Analysis of the ERG\n(Evidence Review Group) reports\nof manufacturers’ submission\n(MS) searches shows what\nmanufacturers do in terms of\nsearching, what ERGs do in\nrelation to appraising searches\nand how they report on the\nappraisal process." + }, + { + "id": 21284, + "strid": "24a65e92-db76-4bf7-ac07-64056fe934d6", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1008.96, + 692.361, + 279.4569999999999, + 57.97799999999995 + ], + "priority": 4, + "parents": [ + 21277 + ], + "children": [ + 21294, + 21291, + 21283 + ], + "area": 698564.55456, + "iscrowd": 0, + "segmentation": [], + "text": "Approach" + }, + { + "id": 21283, + "strid": "bb2be4a2-e86f-4d1b-acc8-80d34fdebf53", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1017.558, + 786.012, + 368.88300000000004, + 141.44299999999998 + ], + "priority": 5, + "parents": [ + 21284 + ], + "children": [], + "area": 799812.7986959999, + "iscrowd": 0, + "segmentation": [], + "text": "2. Limitations from search\ncritiques in 83 (94%) of the 88\nERG reports between 2006 and\nMay 2011 were extracted and\ngrouped into themes." + }, + { + "id": 21291, + "strid": "2a91459d-e0d9-4abe-8793-40af4ede8483", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1133.944, + 142.786, + 616.113, + 574.0729999999999 + ], + "priority": 6, + "parents": [ + 21284 + ], + "children": [], + "area": 161911.327984, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 21294, + "strid": "3bab8e5d-c418-4776-9d0f-ca58228c448d", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 542.821, + 530.422, + 527.6040000000002, + 424.05500000000006 + ], + "priority": 7, + "parents": [ + 21284 + ], + "children": [], + "area": 287924.20046200004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 21281, + "strid": "74407f6d-65c0-4d31-b6c6-fc52d40915f8", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 75.505, + 913.839, + 243.51, + 52.18100000000004 + ], + "priority": 8, + "parents": [ + 21277 + ], + "children": [ + 21286, + 21282 + ], + "area": 68999.413695, + "iscrowd": 0, + "segmentation": [], + "text": "Themes" + }, + { + "id": 21286, + "strid": "6cf37163-1b12-4270-ae2b-d1cf0d1d1e51", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 107.798, + 986.295, + 1454.031, + 69.024 + ], + "priority": 9, + "parents": [ + 21281 + ], + "children": [], + "area": 106320.62840999999, + "iscrowd": 0, + "segmentation": [], + "text": "3. Twelve themes were identified, six themes closely related to the search strategy theme with the most\nlimitations." + }, + { + "id": 21282, + "strid": "88c4f29e-faeb-4c3c-99db-0e4392b4dc93", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 82.812, + 1063.969, + 1609.839, + 177.788 + ], + "priority": 10, + "parents": [ + 21281 + ], + "children": [], + "area": 88109.400828, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 21287, + "strid": "87088fa0-1c79-4c23-951f-458736ee5185", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 708.726, + 1247.18, + 394.4119999999999, + 57.190000000000055 + ], + "priority": 11, + "parents": [ + 21277 + ], + "children": [ + 21288, + 21296, + 21300, + 21285, + 21295, + 21292, + 21289 + ], + "area": 883908.89268, + "iscrowd": 0, + "segmentation": [], + "text": "Comparisons" + }, + { + "id": 21300, + "strid": "d04ed86a-9823-42fe-bab0-42bb139d40c4", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 697.003, + 1315.895, + 417.79499999999996, + 68.13499999999999 + ], + "priority": 12, + "parents": [ + 21287 + ], + "children": [], + "area": 917182.7626850001, + "iscrowd": 0, + "segmentation": [], + "text": "Limitations reported in the\nMS searches by the ERGs" + }, + { + "id": 21285, + "strid": "388bde53-547e-4015-980f-0284484e2241", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 29.232, + 1387.885, + 651.485, + 656.356 + ], + "priority": 13, + "parents": [ + 21287 + ], + "children": [], + "area": 40570.65432, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 21289, + "strid": "de749b8a-0c0c-4fb6-a4e5-b0aeb137c182", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 727.029, + 1486.998, + 420.47900000000004, + 197.25 + ], + "priority": 14, + "parents": [ + 21287 + ], + "children": [], + "area": 1081090.668942, + "iscrowd": 0, + "segmentation": [], + "text": "4. Key limitations relate to either\nomissions (comprehensiveness of\nsearch) and missing full strategies\n(lack transparency and careful\ndocumentation of the MS’s search\nprocess): common in both clinical\nand cost effectiveness reviews." + }, + { + "id": 21292, + "strid": "e32532b5-d25e-48f3-a27b-284e96372cc1", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 709.709, + 1829.54, + 432.98799999999994, + 252.0949999999998 + ], + "priority": 15, + "parents": [ + 21287 + ], + "children": [], + "area": 1298441.0038599998, + "iscrowd": 0, + "segmentation": [], + "text": "5. Search strategy theme: the most\nfrequent limitations relate to the\nfailure to use subject headings or\nthesauri, missing free-text terms,\nerrors in database syntax and errors\nin the combination of lines in\nstatements which will have an\nimpact on the recall and/or precision\nof the search." + }, + { + "id": 21296, + "strid": "c1f7981d-8f9c-4233-8ba1-63e0468d560d", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 709.709, + 2181.703, + 428.177, + 167.42200000000003 + ], + "priority": 16, + "parents": [ + 21287 + ], + "children": [], + "area": 1548374.254427, + "iscrowd": 0, + "segmentation": [], + "text": "7. The appraisal should consist of\ntwo key elements: an assessment of\nthe actual reporting of the searches\nundertaken and a structured critical\nappraisal of the actual strategy\n(including sources)." + }, + { + "id": 21288, + "strid": "faff7340-f896-4391-bdb3-eef5f1df1d50", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1197.034, + 1378.143, + 540.672, + 589.3809999999999 + ], + "priority": 17, + "parents": [ + 21287 + ], + "children": [], + "area": 1649684.0278620003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 21295, + "strid": "a519ce41-2706-4628-bd50-da270217f724", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1247.576, + 2061.429, + 335.80600000000004, + 194.36299999999983 + ], + "priority": 18, + "parents": [ + 21287 + ], + "children": [], + "area": 2571789.346104, + "iscrowd": 0, + "segmentation": [], + "text": "6. The wide range of\nlimitations identified reflects\nthe importance of the\ninformation specialists’ role\nwithin the ERG team in\nassessing the quality of the\nmanufacturers’ searches." + }, + { + "id": 21290, + "strid": "d663069f-df2f-4977-9b5d-d55ac3a98099", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 63.285, + 2167.367, + 290.946, + 47.791999999999916 + ], + "priority": 19, + "parents": [ + 21277 + ], + "children": [ + 21297, + 21302, + 21301, + 21312, + 21303, + 21305, + 21307, + 21308, + 21309, + 21306, + 21311, + 21304, + 21310 + ], + "area": 137161.820595, + "iscrowd": 0, + "segmentation": [], + "text": "Checklist" + }, + { + "id": 21297, + "strid": "035e4d0d-8be0-4022-8ca2-448e21441acd", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 56.169, + 2255.694, + 447.552, + 166.91100000000006 + ], + "priority": 20, + "parents": [ + 21290 + ], + "children": [], + "area": 126700.076286, + "iscrowd": 0, + "segmentation": [], + "text": "8. A checklist based on the themes\ndeveloped from this study that\nincorporates both search strategy and\nreporting elements was created. Below\nare examples of questions from each\ntheme." + }, + { + "id": 21301, + "strid": "f252123a-4e3d-4e00-bc94-1baa3dbde0ab", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 137.701, + 2454.711, + 218.04099999999997, + 90.62699999999995 + ], + "priority": 21, + "parents": [ + 21290 + ], + "children": [], + "area": 338016.159411, + "iscrowd": 0, + "segmentation": [], + "text": "Reporting: Were\nstrategies as described\nin methods fully\nprovided?" + }, + { + "id": 21306, + "strid": "3a0f7991-cdf6-44fb-9df2-1505cfdc2d24", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 137.734, + 2591.393, + 216.00299999999996, + 49.0920000000001 + ], + "priority": 22, + "parents": [ + 21290 + ], + "children": [], + "area": 356922.92346200004, + "iscrowd": 0, + "segmentation": [], + "text": "Overall strategy: Was\nthe strategy clear?" + }, + { + "id": 21307, + "strid": "5494ba58-a300-41f6-b7fd-566274d7a785", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 137.734, + 2704.304, + 171.00199999999998, + 96.54700000000003 + ], + "priority": 23, + "parents": [ + 21290 + ], + "children": [], + "area": 372474.60713600006, + "iscrowd": 0, + "segmentation": [], + "text": "PICO and terms:\nWere terms used\ncorrectly and\nnecessary?" + }, + { + "id": 21302, + "strid": "66eaea3b-cd64-43e1-b9e1-06c42ca5d067", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 428.192, + 2452.3, + 223.36699999999996, + 72.0010000000002 + ], + "priority": 24, + "parents": [ + 21290 + ], + "children": [], + "area": 1050055.2416, + "iscrowd": 0, + "segmentation": [], + "text": "Free-text terms: Were\nthere free-text terms\nmissing?" + }, + { + "id": 21305, + "strid": "75f9594a-66c8-4ad3-aa30-3acab121544f", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 426.556, + 2576.666, + 238.094, + 95.72899999999981 + ], + "priority": 25, + "parents": [ + 21290 + ], + "children": [], + "area": 1099092.342296, + "iscrowd": 0, + "segmentation": [], + "text": "Subject headings: Were\nany subject\nheadings/thesauri\nmissing?" + }, + { + "id": 21308, + "strid": "ad9a7cc2-6272-4caf-a5c8-dd1525c4602d", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 431.465, + 2723.122, + 216.82099999999997, + 47.45499999999993 + ], + "priority": 26, + "parents": [ + 21290 + ], + "children": [], + "area": 1174931.8337299998, + "iscrowd": 0, + "segmentation": [], + "text": "Syntax: Was the\nsyntax used correctly?" + }, + { + "id": 21303, + "strid": "59ed7c97-dab3-407c-a2ed-7bcc819df42a", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 730.106, + 2454.755, + 176.73000000000002, + 72.0010000000002 + ], + "priority": 27, + "parents": [ + 21290 + ], + "children": [], + "area": 1792231.35403, + "iscrowd": 0, + "segmentation": [], + "text": "Structure: Were\nBoolean operators\nused correctly?" + }, + { + "id": 21304, + "strid": "15ed8014-41f1-4096-a503-70e23d352668", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 730.106, + 2582.393, + 212.73000000000002, + 67.90999999999985 + ], + "priority": 28, + "parents": [ + 21290 + ], + "children": [], + "area": 1885420.623658, + "iscrowd": 0, + "segmentation": [], + "text": "Source: Were sources\nmissing in the\nmethods?" + }, + { + "id": 21309, + "strid": "03907592-f984-43e8-8181-030467c75b3a", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 724.379, + 2708.395, + 189.00300000000004, + 69.54599999999982 + ], + "priority": 29, + "parents": [ + 21290 + ], + "children": [], + "area": 1961904.4617050001, + "iscrowd": 0, + "segmentation": [], + "text": "Limits: Were limits\napplied appropriate\nand justified?" + }, + { + "id": 21310, + "strid": "712ae20a-f5e7-422c-9470-eb5972193928", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1027.564, + 2459.091, + 207.6579999999999, + 64.96000000000004 + ], + "priority": 30, + "parents": [ + 21290 + ], + "children": [], + "area": 2526873.384324, + "iscrowd": 0, + "segmentation": [], + "text": "Filters: Was the filter\napplied appropriate\nand sensitive?" + }, + { + "id": 21311, + "strid": "b23bda0a-0719-415f-ae51-ea7f21982e24", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1021.175, + 2591.495, + 191.32899999999995, + 64.25 + ], + "priority": 31, + "parents": [ + 21290 + ], + "children": [], + "area": 2646369.906625, + "iscrowd": 0, + "segmentation": [], + "text": "Translation: Was\ntranslation between\ndatabases correct?" + }, + { + "id": 21312, + "strid": "c1cfe302-8071-43e5-bbdf-82a1a347a67f", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1014.785, + 2704.73, + 218.3069999999999, + 66.02500000000009 + ], + "priority": 32, + "parents": [ + 21290 + ], + "children": [], + "area": 2744719.43305, + "iscrowd": 0, + "segmentation": [], + "text": "Missing studies: Were\nany missing studies\nfound?" + }, + { + "id": 21293, + "strid": "a13c210e-047a-4775-b4c9-ac7893f02d16", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1313.595, + 2355.445, + 292.31999999999994, + 294.45899999999983 + ], + "priority": 33, + "parents": [ + 21277 + ], + "children": [ + 21298, + 21299 + ], + "area": 3094100.7747750003, + "iscrowd": 0, + "segmentation": [], + "text": "&\nWS 9. Man\n\nagencies, i:\nenecialicts" + }, + { + "id": 21298, + "strid": "3cc7d63e-517b-4131-9cef-2fe45bd4288b", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1434.708, + 2576.153, + 301.952, + 255.19799999999987 + ], + "priority": 34, + "parents": [ + 21293 + ], + "children": [], + "area": 3696027.318324, + "iscrowd": 0, + "segmentation": [], + "text": "9. Manufacturers,\nagencies, information\nspecialists involved in\nHTAs will be aware of\n\npotential limitations\nrelating to the search\nmethodology - this would\nimprove the efficiency of\nthe STA process." + }, + { + "id": 21299, + "strid": "b815e27a-1ef9-4936-a45e-065a6fc9bca0", + "image_id": 201347, + "image_name": "116971.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1184.38, + 2845.962, + 547.4099999999999, + 85.7159999999999 + ], + "priority": 35, + "parents": [ + 21293 + ], + "children": [], + "area": 3370700.4735600003, + "iscrowd": 0, + "segmentation": [], + "text": "10, This study provides a checklist for HTA\npractice in the UK and other countries such as\nFrance, Australia and Canada." + }, + { + "id": 73337, + "strid": "70b21a93-25e7-4305-b76a-ea297dbdb1f7", + "image_id": 203357, + "image_name": "120091.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 522.9, + 77.03, + 174.32000000000005, + 174.32 + ], + "priority": -1, + "parents": [], + "children": [ + 73307, + 73308, + 73305, + 73306, + 73304, + 73303, + 73309 + ], + "area": 40278.987, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 73303, + "strid": "7dbe0cc6-5305-47cc-8d1a-80d57a19bb24", + "image_id": 203357, + "image_name": "120091.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 827.603, + 138.48, + 1658.0949999999998, + 166.38900000000004 + ], + "priority": 1, + "parents": [ + 73337 + ], + "children": [], + "area": 114606.46343999998, + "iscrowd": 0, + "segmentation": [], + "text": "Inter-individual differences in cognitive control\npredict amygdala reactivity to fearful faces" + }, + { + "id": 73304, + "strid": "c8b694e3-db4f-4366-bed7-1b16707c139b", + "image_id": 203357, + "image_name": "120091.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 242.319, + 401.847, + 2829.504, + 306.74299999999994 + ], + "priority": 2, + "parents": [ + 73337 + ], + "children": [], + "area": 97375.16319299999, + "iscrowd": 0, + "segmentation": [], + "text": "/ DE GENEVE\n‘Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland\nLaboratory for Behavioral Neurology and Imaging of Cognition, Department of Neuroscience, Medical School, University of Geneva, Geneva, Switzerland\n3Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland\n4Geneva Neuroscience Center, University of Geneva, Geneva, Switzerland\n\nSwann Pichon'#°, Sebastian Walter Rieger?*, Patrik Vuilleumier?*4" + }, + { + "id": 73305, + "strid": "f4c92978-c18f-4c5a-95c8-ec1a4b46433a", + "image_id": 203357, + "image_name": "120091.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1498.671, + 794.097, + 314.81899999999996, + 42.370000000000005 + ], + "priority": 3, + "parents": [ + 73337 + ], + "children": [ + 73310 + ], + "area": 1190090.145087, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 73310, + "strid": "2aa7c251-9a64-4088-a016-67d9e88239ba", + "image_id": 203357, + "image_name": "120091.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 72.927, + 888.454, + 3169.539, + 422.41599999999994 + ], + "priority": 4, + "parents": [ + 73305 + ], + "children": [], + "area": 64792.284858, + "iscrowd": 0, + "segmentation": [], + "text": "Threat-related stimuli are strong competitors for attention, especially in-anxious individuals [3]. To date, many investigations have shed light\non the psychological and neural~processes involved in controlling) attention to emotional stimuli, and@how emotional and attentional\nmodulations combine to regulate sensory processing. However, itremains unknown whether performance in attention control per se, as\nassessed by independenttests, is predictive of inter-individual\\differences in how people react to threat-related stimuli. We hypothesized\nthat 1) higher performance in cognitive tasks (probed in Stroop and D2 tasks) should predict lower reactivity to fearful facesNn\nthe face processing\\network, especially in situations‘where emotional information is.task irrelevant and has to be ignored; 2)\nhigher anxiety levels should predict stronger reactivity to fearful faces in the face processing network." + }, + { + "id": 73306, + "strid": "152c32f3-4acc-4391-981b-b83bdfc5d6d4", + "image_id": 203357, + "image_name": "120091.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1420.437, + 1408.981, + 472.5160000000001, + 52.44699999999989 + ], + "priority": 5, + "parents": [ + 73337 + ], + "children": [ + 73317, + 73313, + 73314, + 73311, + 73315, + 73318, + 73312, + 73316, + 73319 + ], + "area": 2001368.744697, + "iscrowd": 0, + "segmentation": [], + "text": "Protocol & Design" + }, + { + "id": 73311, + "strid": "447fed4c-3574-420d-a323-42becad179f6", + "image_id": 203357, + "image_name": "120091.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 104.63, + 1521.752, + 980.8919999999999, + 42.105999999999995 + ], + "priority": 6, + "parents": [ + 73306 + ], + "children": [], + "area": 159220.91176, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 73312, + "strid": "3f449048-50f1-4abf-a6aa-ebfd7d332954", + "image_id": 203357, + "image_name": "120091.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 132.931, + 1578.608, + 843.237, + 270.1490000000001 + ], + "priority": 7, + "parents": [ + 73306 + ], + "children": [], + "area": 209845.94004800002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 73313, + "strid": "258beeff-727a-4dae-9a2e-f7a807b0bea0", + "image_id": 203357, + "image_name": "120091.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 137.318, + 1858.616, + 926.8700000000001, + 85.33300000000008 + ], + "priority": 8, + "parents": [ + 73306 + ], + "children": [], + "area": 255221.43188800002, + "iscrowd": 0, + "segmentation": [], + "text": "Task: ‘same-different’ judgment of attended houses or\nfaces (fearful or neutral). 256 trials.See refs [1] & [2]" + }, + { + "id": 73316, + "strid": "e7fcdf6a-75ff-410f-a3b6-17f7a58ae93d", + "image_id": 203357, + "image_name": "120091.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1155.708, + 1521.179, + 866.1759999999999, + 85.38699999999994 + ], + "priority": 9, + "parents": [ + 73306 + ], + "children": [], + "area": 1758038.7397320003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 73314, + "strid": "cf2cf45a-4cf9-4d57-9be6-9016a51a04f2", + "image_id": 203357, + "image_name": "120091.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1227.616, + 1630.315, + 716.267, + 151.5809999999999 + ], + "priority": 10, + "parents": [ + 73306 + ], + "children": [], + "area": 2001400.77904, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 73317, + "strid": "6d6182ad-e99a-4012-82ef-d1420f22b007", + "image_id": 203357, + "image_name": "120091.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1227.013, + 1859.587, + 883.172, + 84.97000000000003 + ], + "priority": 11, + "parents": [ + 73306 + ], + "children": [], + "area": 2281737.423631, + "iscrowd": 0, + "segmentation": [], + "text": "Task: name the colormink of the word; 84 trials,\n50% of which colorink and word meaning interfere." + }, + { + "id": 73319, + "strid": "7ec678a2-e159-4300-94dd-b7b93c983011", + "image_id": 203357, + "image_name": "120091.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2097.679, + 1521.552, + 788.049, + 41.615999999999985 + ], + "priority": 12, + "parents": [ + 73306 + ], + "children": [], + "area": 3191727.677808, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 73315, + "strid": "d20966b0-1250-4af2-be30-ab55d08ff821", + "image_id": 203357, + "image_name": "120091.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2038.458, + 1629.773, + 1203.2019999999998, + 142.99800000000005 + ], + "priority": 13, + "parents": [ + 73306 + ], + "children": [], + "area": 3322223.810034, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 73318, + "strid": "309740bf-9c07-451d-a8e2-0a9bbcae0127", + "image_id": 203357, + "image_name": "120091.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2217.081, + 1858.092, + 968.165, + 130.69000000000005 + ], + "priority": 14, + "parents": [ + 73306 + ], + "children": [], + "area": 4119540.4694520007, + "iscrowd": 0, + "segmentation": [], + "text": "Task: detect,each letter d accompanied with 2 quotes (’),\n20s to process each line,\n14 lines Of 47 characters (d, p) each." + }, + { + "id": 73307, + "strid": "5a8b5c0a-5010-4c12-85b3-858d7bef6ffa", + "image_id": 203357, + "image_name": "120091.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1561.692, + 2084.773, + 191.66000000000008, + 42.89499999999998 + ], + "priority": 15, + "parents": [ + 73337 + ], + "children": [ + 73331, + 73332, + 73321, + 73329, + 73330, + 73323, + 73326, + 73334, + 73333, + 73322, + 73320, + 73324, + 73328, + 73327 + ], + "area": 3255773.3159160004, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 73320, + "strid": "a52b0245-f25f-4bd3-a5e4-786a222a75ae", + "image_id": 203357, + "image_name": "120091.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 106.262, + 2213.274, + 923.2840000000001, + 136.55200000000013 + ], + "priority": 16, + "parents": [ + 73307 + ], + "children": [], + "area": 235186.92178799998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 73321, + "strid": "a21a7574-bd37-4538-8cce-2be17942e210", + "image_id": 203357, + "image_name": "120091.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 246.825, + 2381.573, + 644.578, + 936.2240000000002 + ], + "priority": 17, + "parents": [ + 73307 + ], + "children": [], + "area": 587831.7557249999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 73322, + "strid": "6f9aa888-1945-47f7-a7d7-065f21a57f80", + "image_id": 203357, + "image_name": "120091.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 84.229, + 3340.726, + 967.0509999999999, + 219.29800000000023 + ], + "priority": 18, + "parents": [ + 73307 + ], + "children": [], + "area": 281386.010254, + "iscrowd": 0, + "segmentation": [], + "text": "Example trial: Stimuli were displayed for 250/ms\nHere subject focus attention on the vertical bold squares\nwhere pictures of houses appear and judge-whether\nor not they are identical. Fearful faces are therefore task\nirrelevant and receive less attentionthan houses." + }, + { + "id": 73323, + "strid": "c6674dd7-b019-413a-a82c-72b8e4834c79", + "image_id": 203357, + "image_name": "120091.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 107.667, + 3604.376, + 903.665, + 184.85199999999986 + ], + "priority": 19, + "parents": [ + 73307 + ], + "children": [], + "area": 388072.350792, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 73324, + "strid": "15b5dc31-7e1f-4cbe-9fb1-25492d31157c", + "image_id": 203357, + "image_name": "120091.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 108.54, + 3796.703, + 909.849, + 171.64699999999993 + ], + "priority": 20, + "parents": [ + 73307 + ], + "children": [], + "area": 412094.14362000005, + "iscrowd": 0, + "segmentation": [], + "text": "Results: Individuals withxa*high RT cost in Stroop\n(median split, p=0.04?1tailed) or with lower detection\nrates in D2 (correlation, p=0.011) performed worse in\nthe face-housezattention task" + }, + { + "id": 73326, + "strid": "301e5ba0-5284-4d84-8a2e-69ac832d4a52", + "image_id": 203357, + "image_name": "120091.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1089.184, + 2213.564, + 697.155, + 202.21799999999985 + ], + "priority": 21, + "parents": [ + 73307 + ], + "children": [], + "area": 2410978.491776, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 73327, + "strid": "bd387ebd-f668-464f-8eef-e3b9ce8ee5bd", + "image_id": 203357, + "image_name": "120091.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1076.728, + 2427.106, + 718.1610000000001, + 1555.382 + ], + "priority": 22, + "parents": [ + 73307 + ], + "children": [], + "area": 2613332.9891680004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 73333, + "strid": "71223419-41be-497c-928a-68fef92c6fc0", + "image_id": 203357, + "image_name": "120091.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1834.37, + 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task" + }, + { + "id": 73334, + "strid": "79eb06c6-5e28-47c2-a8b5-92a608b10176", + "image_id": 203357, + "image_name": "120091.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2539.461, + 2214.485, + 663.3519999999999, + 204.39100000000008 + ], + "priority": 26, + "parents": [ + 73307 + ], + "children": [], + "area": 5623598.292584999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 73329, + "strid": "855c968f-8a6f-4d16-9a7e-803f2aca6ceb", + "image_id": 203357, + "image_name": "120091.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2513.747, + 2434.098, + 691.154, + 919.5900000000001 + ], + "priority": 27, + "parents": [ + 73307 + ], + "children": [], + "area": 6118706.545205999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 73331, + "strid": "f6186f1b-1468-4715-9206-599d0e92f0ee", + "image_id": 203357, + "image_name": "120091.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2788.506, + 3371.725, + 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+ }, + { + "id": 73325, + "strid": "e33fac3b-28ee-4da6-9e93-a814c90bb7e7", + "image_id": 203357, + "image_name": "120091.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 191.982, + 4065.481, + 1664.453, + 524.1410000000001 + ], + "priority": 31, + "parents": [ + 73308 + ], + "children": [], + "area": 780499.173342, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 73309, + "strid": "6b63e27f-182a-4d3b-8803-c737fefc65df", + "image_id": 203357, + "image_name": "120091.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1946.657, + 4125.737, + 42.789999999999964, + 395.46200000000044 + ], + "priority": 32, + "parents": [ + 73337 + ], + "children": [ + 73336, + 73335 + ], + "area": 8031394.811209, + "iscrowd": 0, + "segmentation": [], + "text": "ao P ie, omeey OL O10 RTS) /A\\)" + }, + { + "id": 73335, + "strid": "72bf42e0-8256-4298-9dcf-08e7357d7c34", + "image_id": 203357, + "image_name": "120091.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2056.327, + 4052.278, + 1188.855, + 387.31600000000026 + ], + "priority": 33, + "parents": [ + 73309 + ], + "children": [], + "area": 8332808.662906, + "iscrowd": 0, + "segmentation": [], + "text": "Subject’s FFX: 4 regressors modeled the attention task (fearful, neutral) *\n(attended, unattended) + time derivatives of.th€é,6 movement parameters. 3\nregressors modeled the Stroop task (congruent trials, incongruent and neutral\nones). We also acquired a face & house \\ocalizer for region-of-interest (ROI)\nanalyses.\n\nGroup RFX: Simple regression médels. SPM thresholded at 0.05 uncorrected\nfor display and FWE corrected _for @ priori regions of interest.\n\nCorrection for multiple comparisons: Small volume correction (FWE p<.05)\nwith a priori ROI from a faee localiser (amygdala, FFA, PPA)" + }, + { + "id": 73336, + "strid": "4e3bc073-14a5-46ea-8941-6a2ddce312e6", + "image_id": 203357, + "image_name": "120091.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2056.5, + 4444.948, + 837.4169999999999, + 154.26400000000012 + ], + "priority": 34, + "parents": [ + 73309 + ], + "children": [], + "area": 9141035.562, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 140306, + "strid": "43db7c66-5e88-487f-a274-75225210fe19", + "image_id": 205956, + "image_name": "16810.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 52.75, + 78.61, + 240.61, + 372.56 + ], + "priority": -1, + "parents": [], + "children": [ + 140294, + 140289, + 140286, + 140290, + 140287, + 140300, + 140293, + 140288 + ], + "area": 4146.6775, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 140293, + "strid": "51880103-b67a-4e17-9364-54e85718dc2d", + "image_id": 205956, + "image_name": "16810.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 331.616, + 33.511, + 1941.02, + 203.13 + ], + "priority": 1, + "parents": [ + 140306 + ], + "children": [], + "area": 11112.783776, + "iscrowd": 0, + "segmentation": [], + "text": "Benchmarking metagenomic classification tools for\nlong read sequencing data" + }, + { + "id": 140294, + "strid": "63d40240-355a-40a7-be35-0490b3c39c7b", + "image_id": 205956, + "image_name": "16810.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 298.787, + 246.021, + 1834.9109999999998, + 183.198 + ], + "priority": 2, + "parents": [ + 140306 + ], + "children": [], + "area": 73507.87652699999, + "iscrowd": 0, + "segmentation": [], + "text": "Josip Maric’, Sylvain Riondet?, Kresimir Krizanovic?, Niranjan Nagarajan? and Mile Siki¢??\n1 Faculty of Electrical Engineering and Computing, University of Zagreb, Croatia\n? National University of Singapore 3 A*STAR Genome Institute of Singapore" + }, + { + "id": 140290, + "strid": "24ac47f9-5200-4644-8349-bf22aec2ad72", + "image_id": 205956, + "image_name": "16810.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 317.322, + 541.349, + 437.3929999999999, + 50.01200000000006 + ], + "priority": 3, + "parents": [ + 140306 + ], + "children": [ + 140279 + ], + "area": 171781.947378, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 140279, + "strid": "c09c2414-f58c-4d2e-af3e-88c8367394fd", + "image_id": 205956, + "image_name": "16810.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 335.664, + 653.756, + 1339.284, + 876.786 + ], + "priority": 4, + "parents": [ + 140290 + ], + "children": [], + "area": 219442.353984, + "iscrowd": 0, + "segmentation": [], + "text": "In recent years, both long-read sequencing and\nmetagenomic analysis have been significantly advanced.\nAlthough long-read sequencing technologies have been\nprimarily used for de novo genome assembly, they are rapidly\nmaturing for widespread use in other applications. In\nparticular, long reads could potentially lead to more precise\ntaxonomic identification which has sparked an interest in\nusing them for metagenomic analysis.\n\nHere we present a benchmark of several tools for\nmetagenomic taxonomic classification, tested on_in-silico\ndatasets that were constructed using real long reads from\nisolate sequencing. The tools were tested on their ability to\ndetect species in the sample and to correctly estimate the\nabundance of each species." + }, + { + "id": 140288, + "strid": "2175cbf3-7e97-4a9b-b8d8-b0c40d28a9fd", + "image_id": 205956, + "image_name": "16810.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 347.575, + 1638.695, + 448.988, + 51.580999999999904 + ], + "priority": 5, + "parents": [ + 140306 + ], + "children": [ + 140281, + 140304, + 140301, + 140291, + 140295, + 140297, + 140282, + 140280, + 140302, + 140296 + ], + "area": 569569.414625, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 140280, + "strid": "be51e040-3ac6-4da1-941b-c9837fcaa5e8", + "image_id": 205956, + "image_name": "16810.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 337.17, + 1767.064, + 1349.829, + 298.2879999999998 + ], + "priority": 6, + "parents": [ + 140288 + ], + "children": [], + "area": 595800.9688800001, + "iscrowd": 0, + "segmentation": [], + "text": "Tested metagenomic classification tools were either newly\ndeveloped or adapted for long read data. They were tested on\ntest datasets constructed from varying number of bacterial\nand eukaryotic genomes. The tools were tested on two\ndifferent databases:" + }, + { + "id": 140291, + "strid": "2284d3cc-2a55-4e6b-825d-ceee20d858f7", + "image_id": 205956, + "image_name": "16810.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 339.238, + 2080.808, + 1345.37, + 245.17000000000007 + ], + "priority": 7, + "parents": [ + 140288 + ], + "children": [], + "area": 705889.144304, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 140301, + "strid": "b6f65829-4c40-4aed-ba6f-351675cc8d09", + "image_id": 205956, + "image_name": "16810.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 319.269, + 2360.436, + 267.15200000000004, + 40.18100000000004 + ], + "priority": 8, + "parents": [ + 140288 + ], + "children": [], + "area": 753614.041284, + "iscrowd": 0, + "segmentation": [], + "text": "Tested tools:" + }, + { + "id": 140295, + "strid": "35e37ddf-74c0-4596-a0b3-85ed8513b35e", + "image_id": 205956, + "image_name": "16810.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 309.465, + 2413.481, + 1399.284, + 143.06899999999996 + ], + "priority": 9, + "parents": [ + 140288 + ], + "children": [], + "area": 746887.897665, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 140281, + "strid": "14d2aced-eefe-4e3b-97f0-e1cc583b751f", + "image_id": 205956, + "image_name": "16810.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 329.638, + 2599.106, + 1348.097, + 243.60300000000007 + ], + "priority": 10, + "parents": [ + 140288 + ], + "children": [], + "area": 856764.103628, + "iscrowd": 0, + "segmentation": [], + "text": "Test dataset were constructed from publicly available\nPacBio and ONT datasets obtained by isolate sequencing.\nReads from downloaded datasets were mixed together to\nconstruct test data of varying complexity." + }, + { + "id": 140304, + "strid": "90ce723c-5769-4117-8324-62fdf4f24c38", + "image_id": 205956, + "image_name": "16810.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 339.903, + 2882.794, + 295.38699999999994, + 39.0949999999998 + ], + "priority": 11, + "parents": [ + 140288 + ], + "children": [], + "area": 979870.328982, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 140296, + "strid": "8c740e38-041c-476d-bdb9-534b9936f0e2", + "image_id": 205956, + "image_name": "16810.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 328.657, + 2929.924, + 1355.665, + 396.0569999999998 + ], + "priority": 12, + "parents": [ + 140288 + ], + "children": [], + "area": 962940.032068, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 140302, + "strid": "61ef5d6a-97b1-48f4-adef-4da4c1ee80f6", + "image_id": 205956, + "image_name": "16810.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 341.747, + 3339.945, + 337.65799999999996, + 43.18899999999985 + ], + "priority": 13, + "parents": [ + 140288 + ], + "children": [], + "area": 1141416.1839150002, + "iscrowd": 0, + "segmentation": [], + "text": "PacBio datasets:" + }, + { + "id": 140297, + "strid": "0f8845a6-8ee1-46d8-9c61-942a0cccd98f", + "image_id": 205956, + "image_name": "16810.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 328.657, + 3390.537, + 1355.665, + 649.0439999999999 + ], + "priority": 14, + "parents": [ + 140288 + ], + "children": [], + "area": 1114323.718809, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 140282, + "strid": "abc699da-ccd3-463c-bea0-a06695be9f17", + "image_id": 205956, + "image_name": "16810.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 330.272, + 4074.708, + 1346.619, + 244.00800000000027 + ], + "priority": 15, + "parents": [ + 140288 + ], + "children": [], + "area": 1345761.960576, + "iscrowd": 0, + "segmentation": [], + "text": "Each tool was run to produce taxonomic classification for\neach read. Only a species level classifications were considered\nand used to calculate the number of correctly classified reads\nand the number of detected species for each dataset." + }, + { + "id": 140289, + "strid": "072f5b1b-04ac-486d-b06b-e9f7109b6508", + "image_id": 205956, + "image_name": "16810.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1851.147, + 529.245, + 233.54700000000003, + 51.26700000000005 + ], + "priority": 16, + "parents": [ + 140306 + ], + "children": [ + 140305, + 140299, + 140303, + 140298, + 140284 + ], + "area": 979710.294015, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 140284, + "strid": "de07057d-04a1-4981-bd33-8f9f2eb98ab7", + "image_id": 205956, + "image_name": "16810.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1842.803, + 657.851, + 1390.2279999999998, + 240.23799999999994 + ], + "priority": 17, + "parents": [ + 140289 + ], + "children": [], + "area": 1212289.796353, + "iscrowd": 0, + "segmentation": [], + "text": "Testing results are shown in two tables below. Two values are\ndisplayed for each tool and dataset: percentage of correctly\nclassified reads (shown in blue) and the number of correctly\ndetected species (shown in green)." + }, + { + "id": 140305, + "strid": "28d68eb2-f206-4871-9d23-0ce5c6a64e27", + "image_id": 205956, + "image_name": "16810.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1836.875, + 916.735, + 370.59000000000015, + 44.514999999999986 + ], + "priority": 18, + "parents": [ + 140289 + ], + "children": [], + "area": 1683927.6031250001, + "iscrowd": 0, + "segmentation": [], + "text": "Default database:" + }, + { + "id": 140299, + "strid": "2ce95d7b-f848-4578-aa42-0d1b9d823b2d", + "image_id": 205956, + "image_name": "16810.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1824.151, + 968.833, + 1433.182, + 637.6619999999999 + ], + "priority": 19, + "parents": [ + 140289 + ], + "children": [], + "area": 1767297.685783, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 140303, + "strid": "e95c7fcb-de6a-432d-a4fe-3efc746c1e33", + "image_id": 205956, + "image_name": "16810.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1836.875, + 1643.448, + 527.5070000000001, + 47.85400000000004 + ], + "priority": 20, + "parents": [ + 140289 + ], + "children": [], + "area": 3018808.5450000004, + "iscrowd": 0, + "segmentation": [], + "text": "Custom RefSeq database:" + }, + { + "id": 140298, + "strid": "8a22a609-f591-4432-8378-e89e9a47ca66", + "image_id": 205956, + "image_name": "16810.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1822.074, + 1691.655, + 1433.1820000000002, + 639.7390000000003 + ], + "priority": 21, + "parents": [ + 140289 + ], + "children": [], + "area": 3082320.59247, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 140287, + "strid": "e3d7da16-008b-4c3e-879b-dceb782a85ef", + "image_id": 205956, + "image_name": "16810.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1845.831, + 2433.146, + 398.365, + 55.585999999999785 + ], + "priority": 22, + "parents": [ + 140306 + ], + "children": [ + 140283 + ], + "area": 4491176.314326, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 140283, + "strid": "21df60b8-dc3b-4a6a-a63d-075e1ead1a77", + "image_id": 205956, + "image_name": "16810.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1819.835, + 2539.047, + 1398.7039999999997, + 867.6289999999999 + ], + "priority": 23, + "parents": [ + 140287 + ], + "children": [], + "area": 4620646.597245, + "iscrowd": 0, + "segmentation": [], + "text": "Looking at the testing results shown in the tables above, we\ncan draw two main conclusions.\n\nThe results on the default database vary wildly across\ndatasets, but also across tools. Species not present in the\ndatabase can not be detected. It can be concluded that\nCentrifuge and Metamaps have the most complete default\ndatabase, but in some cases still inferior to CLARK or MEGAN-LR.\n\nWhen using the same database, Centrifuge and Metamaps\ndisplay the best results, where Metamaps classifies more reads\ncorrectly in general, but is less correct in classifying human\nreads. However, the results in general are much more uniform\nthen for default database, leading to the conclusion that the\nchoice of database has greater impact on the analysis than the\nchoice of tool." + }, + { + "id": 140286, + "strid": "bbc811cf-abdb-47d1-a475-2df6b7dca08b", + "image_id": 205956, + "image_name": "16810.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 336.684, + 4411.571, + 606.1890000000001, + 48.430999999999585 + ], + "priority": 24, + "parents": [ + 140306 + ], + "children": [ + 140285 + ], + "area": 1485305.370564, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 140285, + "strid": "beb019e3-5838-4316-9ca9-6afb838179f0", + "image_id": 205956, + "image_name": "16810.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 322.962, + 4504.59, + 1463.41, + 105.99799999999959 + ], + "priority": 25, + "parents": [ + 140286 + ], + "children": [], + "area": 1454811.39558, + "iscrowd": 0, + "segmentation": [], + "text": "This research was funded by the A*STAR Singapore and also by Croatian\nScience Foundation, under the grant HRZZ-IP-2018-01-5886 (SIGMA)." + }, + { + "id": 140300, + "strid": "8a895c60-fe69-4998-bdf2-f25b27617b84", + "image_id": 205956, + "image_name": "16810.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1866.807, + 3536.844, + 348.4379999999999, + 51.06399999999985 + ], + "priority": 26, + "parents": [ + 140306 + ], + "children": [ + 140292 + ], + "area": 6602605.137108, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 140292, + "strid": "4d4042cb-8480-43b7-9161-5ddc406d2bb8", + "image_id": 205956, + "image_name": "16810.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1816.639, + 3636.339, + 1432.251, + 687.6869999999999 + ], + "priority": 27, + "parents": [ + 140300 + ], + "children": [], + "area": 6605915.244620999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 68484, + "strid": "0aeda397-7046-478f-9f81-b69733ab995a", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 2009.87, + 80.86, + 444.97000000000025, + 325.16999999999996 + ], + "priority": -1, + "parents": [], + "children": [ + 68444, + 68449, + 68447, + 68450, + 68445, + 68448, + 68446 + ], + "area": 162518.0882, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 68444, + "strid": "a67ede83-a3b1-416a-92e6-7a0370cd7319", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 2817.06, + 138.624, + 3331.832, + 186.453 + ], + "priority": 1, + "parents": [ + 68484 + ], + "children": [], + "area": 390512.12544, + "iscrowd": 0, + "segmentation": [], + "text": "Visual Attentioniin Dynamic Environments" + }, + { + "id": 68445, + "strid": "a59b6367-ccbc-477e-be0c-e71927151a0a", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 3777.102, + 349.545, + 1445.5479999999998, + 246.09499999999997 + ], + "priority": 2, + "parents": [ + 68484 + ], + "children": [], + "area": 1320267.11859, + "iscrowd": 0, + "segmentation": [], + "text": "Yuvia Kotseruba, John K. Tsotsos\n\nDept. of Electrical Engineering and Computer Science\n\nande€enter for Vision Research York University , Toronto, Canada\n{yulia_k, tsotsos}@cse.yorku.ca" + }, + { + "id": 68446, + "strid": "47b537ca-4fad-437a-a09b-1a94126528ab", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 127.043, + 577.028, + 498.3929999999999, + 57.90499999999997 + ], + "priority": 3, + "parents": [ + 68484 + ], + "children": [ + 68451, + 68469 + ], + "area": 73307.36820400001, + "iscrowd": 0, + "segmentation": [], + "text": "1. INTRODUCTION" + }, + { + "id": 68451, + "strid": "c4c97f93-3048-413c-ac75-be08e8d353dd", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 123.966, + 648.746, + 2749.714, + 334.7679999999999 + ], + "priority": 4, + "parents": [ + 68446 + ], + "children": [], + "area": 80422.446636, + "iscrowd": 0, + "segmentation": [], + "text": "The main purpose of this project was to ‘show how attentional mechanisms help solving complex visual tasks. Onlin@endless scroller games provide\nsufficiently complex and dynami¢allyYechanging visual environment and also have a very simple gameplay, so there is noneed in developing complicated\ngame Al (which is out of scope of,this research). CANABALT (www.adamatomic.com/canabalt) is one example of’such games. The goal is to make runner\ngo as far as possible without hitting’an obstacle or falling into the gap between the buildings. The only controltis “X¥button which makes the runner jump.\nThis game is relevant for studying visual attention because the decisions must be made in less than 1/4 of a Second with many distractors - flocks of birds,\nzooming jets and shaking ground, so it mainly tests focus and reaction time, not tactical skills. Game runs at approx. 72 fps and ~20 fps is the lowest rate at\nwhich it is still playable by a human player. This sets a time limit of ~33 msec to analyze one frame. Bélow afe some screenshots of the game." + }, + { + "id": 68469, + "strid": "5967e347-9b8f-4f67-a0ee-2f7d920da189", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 153.883, + 1055.653, + 2709.467, + 871.577 + ], + "priority": 5, + "parents": [ + 68446 + ], + "children": [], + "area": 162447.050599, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 68447, + "strid": "ebc497a1-e843-4ab0-9d82-cf07da510342", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 136.047, + 2100.684, + 852.345, + 49.346000000000004 + ], + "priority": 6, + "parents": [ + 68484 + ], + "children": [ + 68468, + 68452 + ], + "area": 285791.756148, + "iscrowd": 0, + "segmentation": [], + "text": "2. THEORETICAL BACKGROUND" + }, + { + "id": 68452, + "strid": "ea96fc76-a53d-4d6d-8ba3-15a39fffbcc3", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 130.893, + 2170.208, + 2772.801, + 313.98900000000003 + ], + "priority": 7, + "parents": [ + 68447 + ], + "children": [], + "area": 284065.035744, + "iscrowd": 0, + "segmentation": [], + "text": "Selective Tuning was the theoretical.foundation as a general model of attentional mechanisms (Tsotsos 2011). Cognitive Programs (Tsotsos, 2013) provide\ntask control for attention. SIgwith Cognitive Programs is shown below. In order to build a prototype running in real-time several parts of the model had to be\nomitted or simplified: the*visualpyramid (VH) for processing images is simplified to include only detecting/oriented line segments, locations of objects and\nestimation of translationalmotion; visual task executive (vTE) contains rule-based game Al (see section 4); peripheral priority map (PPM) is computed using\nthe AIM model (Bruce*& Tsotsos 2009); the long-term memory for methods (mLTM) contains only(model of jump physics; most of the executive controller\n(vAE) is not implemented except for the parts used by the game Al." + }, + { + "id": 68468, + "strid": "d28cee83-ae3c-47ae-af8d-4d54542b7dc8", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 462.668, + 2544.841, + 2096.296, + 1505.3759999999997 + ], + "priority": 8, + "parents": [ + 68447 + ], + "children": [], + "area": 1177416.495788, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 68448, + "strid": "45a6ab49-8a49-4f81-bd42-b9516e5cfd67", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3129.948, + 736.647, + 746.2779999999998, + 52.980999999999995 + ], + "priority": 9, + "parents": [ + 68484 + ], + "children": [ + 68466, + 68477, + 68480, + 68453, + 68483, + 68478, + 68456, + 68455, + 68472, + 68474, + 68475, + 68476, + 68471, + 68467, + 68470, + 68479, + 68473, + 68482, + 68454, + 68481 + ], + "area": 2305666.804356, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 68453, + "strid": "a8d3d4d7-d685-4bd8-ba87-01b7bbd7fd63", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3128.61, + 808.832, + 2685.4010000000003, + 362.45799999999997 + ], + "priority": 10, + "parents": [ + 68448 + ], + "children": [], + "area": 2530519.88352, + "iscrowd": 0, + "segmentation": [], + "text": "Below is the diagram, ofthe processing done for each frame with visualization of some intermediate steps? The result of these calculations is to find the\nlocations of the runner; rooftop, obstacles (crates, robots, gaps between the buildings), estimate current speed and compute desired trajectory. All this\ninformation is then passed to the game Al which decides when to press the 'X’ button and when*tojrelease it. All frames are resized to 1024x256 px to\n\noptimize GPU kernels.\n\nAll patalleVcalculations are done on GPU - foveation, filtering with Sobel, Gabor andGaussian kernels, accumulator matrix for Hough transform, building\nsaliency map (AIM), classification with CNN. Total time for all these operations is.~5ms_ per frame + 5ms for overhead and memory transfers." + }, + { + "id": 68466, + "strid": "a599357e-1794-4b06-83ed-2f34b6e887ea", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3118.05, + 1361.329, + 1186.1189999999997, + 193.26600000000008 + ], + "priority": 11, + "parents": [ + 68448 + ], + "children": [], + "area": 4244691.88845, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 68480, + "strid": "d295c396-34f9-493b-b429-6cfc1ddc232b", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4408.247, + 1495.068, + 164.83200000000033, + 42.069999999999936 + ], + "priority": 12, + "parents": [ + 68448 + ], + "children": [], + "area": 6590629.025796, + "iscrowd": 0, + "segmentation": [], + "text": "foveate" + }, + { + "id": 68470, + "strid": "b17bcfe2-20cd-4d51-9c40-576375fa53e7", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 4693.414, + 1361.854, + 1189.5150000000003, + 302.71699999999987 + ], + "priority": 13, + "parents": [ + 68448 + ], + "children": [], + "area": 6391744.629556, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 68482, + "strid": "042a7830-7828-4251-83c1-3d57b5d32d84", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 5229.233, + 1740.17, + 86.5069999999996, + 36.46900000000005 + ], + "priority": 14, + "parents": [ + 68448 + ], + "children": [], + "area": 9099754.38961, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 68481, + "strid": "5ce5de74-8622-4acd-aef5-683188d0e142", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4527.632, + 1789.723, + 137.8180000000002, + 87.96900000000005 + ], + "priority": 15, + "parents": [ + 68448 + ], + "children": [], + "area": 8103207.125935999, + "iscrowd": 0, + "segmentation": [], + "text": "detect\nedges" + }, + { + "id": 68473, + "strid": "42e89ad0-3c45-4af2-9d1d-bbd701fc29af", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3118.835, + 1851.024, + 1185.1449999999995, + 301.57299999999987 + ], + "priority": 16, + "parents": [ + 68448 + ], + "children": [], + "area": 5773038.437039999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 68472, + "strid": "b1dc0868-8be4-4132-bca4-270208537fd9", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 4693.509, + 1851.769, + 1177.455, + 302.62900000000013 + ], + "priority": 17, + "parents": [ + 68448 + ], + "children": [], + "area": 8691294.467421, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 68479, + "strid": "2c04b8fd-7f7d-4887-9344-00563d797706", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3570.077, + 2203.833, + 208.92799999999988, + 90.83800000000019 + ], + "priority": 18, + "parents": [ + 68448 + ], + "children": [], + "area": 7867853.505141001, + "iscrowd": 0, + "segmentation": [], + "text": "find line\nsegments" + }, + { + "id": 68483, + "strid": "cfcbcfee-f0af-4363-8516-bb336aa4526b", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 5057.773, + 2168.183, + 436.77700000000004, + 156.19399999999996 + ], + "priority": 19, + "parents": [ + 68448 + ], + "children": [], + "area": 10966177.436459001, + "iscrowd": 0, + "segmentation": [], + "text": "run classifier on max\npoints + mean\nshift to localize\nclusters" + }, + { + "id": 68474, + "strid": "0bc54dc5-50df-4fdb-9552-f8201b004375", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3117.258, + 2341.43, + 1188.6909999999998, + 303.19299999999976 + ], + "priority": 20, + "parents": [ + 68448 + ], + "children": [], + "area": 7298841.398939999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 68471, + "strid": "b1676343-4d50-431d-8b01-7ff2c6c8050c", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 4693.414, + 2342.858, + 1178.21, + 305.2289999999998 + ], + "priority": 21, + "parents": [ + 68448 + ], + "children": [], + "area": 10996002.537212001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 68454, + "strid": "6cb0be90-aa95-40c0-af16-d878d925fe02", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3111.788, + 2762.486, + 804.739, + 646.665 + ], + "priority": 22, + "parents": [ + 68448 + ], + "children": [], + "area": 8596270.784968, + "iscrowd": 0, + "segmentation": [], + "text": "TEMPORAL CONSISTENCY\n\nFalse detections of the objects cause the most issues\nfor the game Al, so for good performance it is\nimportant to deal with such errors.\n\nSince computing optical flow is infeasible under our\ntime restriction, we simply measure displacement.\nbetween all candidate objects found by the classifier\nand objects found in the previous frame.\n\nMatch objects with the same amount of horizontal\nisplacement.\n\nDiscard all unmatched objects whose motion is\ninconsistent with the previous frame: displacement\ntoo large, if it is a new object, then it cannot appear\nin the middle of the frame, etc.\n\nRemove all lines which contain too many gaps, a\ntoo short or do not correspond to any lin@s in t\nprevious frame." + }, + { + "id": 68478, + "strid": "b27aadc3-5380-44e1-bf4b-c2d6cbd517db", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4298.684, + 2809.754, + 391.46399999999994, + 155.9119999999998 + ], + "priority": 23, + "parents": [ + 68448 + ], + "children": [], + "area": 12078244.563736001, + "iscrowd": 0, + "segmentation": [], + "text": "Tom p evidence\nreve\n\nframes f ° cl ean up" + }, + { + "id": 68475, + "strid": "2a594db8-51dc-4bb8-b9e4-935a4af05115", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3925.043, + 2974.815, + 1180.2999999999997, + 372.1500000000001 + ], + "priority": 24, + "parents": [ + 68448 + ], + "children": [], + "area": 11676276.792045001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 68477, + "strid": "50d388a4-fc2c-409b-aee3-140996e64243", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4210.478, + 3513.837, + 616.0659999999998, + 176.17700000000013 + ], + "priority": 25, + "parents": [ + 68448 + ], + "children": [], + "area": 14794933.384086, + "iscrowd": 0, + "segmentation": [], + "text": "RUNNER COORDINATES\nROOFTOP ENDPOINTS\nOBSTACLES COORDINATES\nCURRENT SPEED" + }, + { + "id": 68455, + "strid": "08ec2323-adbd-4bef-9f85-f3611748c391", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3113.19, + 3567.996, + 762.6910000000003, + 177.6840000000002 + ], + "priority": 26, + "parents": [ + 68448 + ], + "children": [], + "area": 11107849.46724, + "iscrowd": 0, + "segmentation": [], + "text": "CURRENT SPEED aN, _\nCurrent speed is estimat€d}frorm displacement.\nHowever, because the ser, ots are sampled at\n\nirregular intervals a ogeSsing introduces some\nnoise to the data, s smoothing is required:" + }, + { + "id": 68467, + "strid": "eedbdc8d-1813-41bc-b8e6-71c3e96703c5", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3116.424, + 3764.265, + 779.4629999999997, + 149.58599999999979 + ], + "priority": 27, + "parents": [ + 68448 + ], + "children": [], + "area": 11731045.78836, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 68456, + "strid": "4148d199-99ef-49b1-8dfb-4278b1d3e203", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 5055.447, + 3584.398, + 799.6390000000001, + 318.0880000000002 + ], + "priority": 28, + "parents": [ + 68448 + ], + "children": [], + "area": 18120734.115906, + "iscrowd": 0, + "segmentation": [], + "text": "OBJECT CLASSIFICATION\n\nTrain offline a convolutional neural network with 4\nlayers on ~60,000 30x30 patches trom game\nscreenshots.\n\nSort patches into 4 classes: non-lethal obstacles\n(crates, furniture), lethal obstacles (drills), runner and\ndistractors (birds, rocks, broken glass).\n\nAccuracy of recognition is 99.98%." + }, + { + "id": 68476, + "strid": "3b6c2cf7-859a-4e9f-8b04-3fbbd907b806", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4270.312, + 3891.676, + 497.5069999999996, + 40.996999999999844 + ], + "priority": 29, + "parents": [ + 68448 + ], + "children": [], + "area": 16618670.722911999, + "iscrowd": 0, + "segmentation": [], + "text": "RULE-BASED GAME Al" + }, + { + "id": 68450, + "strid": "f5d38984-7018-44aa-9c86-76de8400f9f4", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 6121.757, + 555.834, + 301.2489999999998, + 45.668000000000006 + ], + "priority": 30, + "parents": [ + 68484 + ], + "children": [ + 68461, + 68463, + 68464, + 68462 + ], + "area": 3402680.6803379995, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 68462, + "strid": "96e536be-bd5b-44f8-9704-a2d0ba039bce", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 6120.622, + 621.648, + 2756.862, + 263.068 + ], + "priority": 31, + "parents": [ + 68450 + ], + "children": [], + "area": 3804872.4250560002, + "iscrowd": 0, + "segmentation": [], + "text": "Development of efficient Game Al wasn't among the objectives but some sort of agent was still necessary.to verify that the information from the visual\n\nalgorithms is relevant*to playing the game. There is a general consensus among the players of Camabalt that the best strategy for this game is to plan jumps\nso that the.runnenlands as close to the edge as possible, which gives extra time to react to obsta¢les located on the rooftop. This was the basis for the rule-\nbased strategy implemented for the project. There is no planning involved, nor is it necessary*since the game is very fast paced and tests focus and reaction\n\ntime. Belowaissthe outline of finite state machine controlling the runner:" + }, + { + "id": 68463, + "strid": "2a4e454d-19ea-4a85-8a90-5dab15bfc719", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 6122.999, + 954.489, + 2731.0419999999995, + 745.656 + ], + "priority": 32, + "parents": [ + 68450 + ], + "children": [], + "area": 5844335.192511, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 68464, + "strid": "03dfb2a9-8c59-4110-9f1e-cb07572fc414", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 6201.808, + 1736.519, + 839.6210000000001, + 384.95299999999975 + ], + "priority": 33, + "parents": [ + 68450 + ], + "children": [], + "area": 10769557.426352, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 68461, + "strid": "2fc2fb1f-f1e1-4640-bbb2-9c419833265e", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 7104.367, + 1737.738, + 1672.5959999999995, + 330.56700000000023 + ], + "priority": 34, + "parents": [ + 68450 + ], + "children": [], + "area": 12345528.501846, + "iscrowd": 0, + "segmentation": [], + "text": "JUMP PHYSICS\n\nTrajectory of the jump depends on the current speed, time since the last jump and duration of the button press. Initially the\nalgorithm holds the button randomly and records position of the runner and displa€ement for each frame. When the game is\nfinished, this data is parsed by Matlab script to fit a parabola to each trajectory. Then a neural network with one hidden layer\nis trained. Its inputs are: speed, time since last jump and coefficients of the parabola. The output is a single value of timer for\nbutton press.\n\nDuring runtime when the runner approaches an obstacle, the desired ‘trajectory is computed as the parabola through 3 points:\nrunner's location, obstacle location + offset in x and y directi6fs, (amount depends on the current speed)." + }, + { + "id": 68449, + "strid": "f6cc7a43-3bc6-4e25-95b6-a48cbd395d0b", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 6124.319, + 2269.086, + 288.53200000000015, + 48.39899999999989 + ], + "priority": 35, + "parents": [ + 68484 + ], + "children": [ + 68459, + 68465, + 68457, + 68458, + 68460 + ], + "area": 13896606.502434, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 68457, + "strid": "50c0e617-d120-414d-9b12-5730b4154e54", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 6123.815, + 2415.834, + 2730.5729999999994, + 258.39800000000014 + ], + "priority": 36, + "parents": [ + 68449 + ], + "children": [], + "area": 14794120.486709999, + "iscrowd": 0, + "segmentation": [], + "text": "Real-time performance of 40-80 fps\n\nAlgorithm achieves real-time performance of 40-80 fps depending on the complexity of the frames. Visual processing is written in OpenCL and runs on two\nAMD FirePro W5000 video card. Game Al and all infrastructure for visualization; debugging and training of classifiers is implemented in C++ and Matlab.\nUse of foveation and saliency maps is essential in achieving this framerate. 7 he highest score that the algorithm has ever reached was around 10,000 m;\nwhich is definitely above the beginner level (the best recorded s¢ore for PC on Kongregate is 29,480m, the median score is ~5,000m)." + }, + { + "id": 68458, + "strid": "62ffa00f-95c8-4d63-833e-197b53f02353", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 6121.33, + 2731.378, + 2775.2960000000003, + 154.04500000000007 + ], + "priority": 37, + "parents": [ + 68449 + ], + "children": [], + "area": 16719666.092740001, + "iscrowd": 0, + "segmentation": [], + "text": "Imitation of human behaviour\nOnline games were chosen to so that we couldn't take advantage of the game engine. Our algorithm ‘sees’ exactly what a human player seesjit takes longer\nto process tricky frames with many distractors and ‘ey€ym6vements’ of the algorithm were based on the eye tracking data from the author." + }, + { + "id": 68459, + "strid": "6cf24d39-b40b-4425-8e1c-fe948c63344a", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 6121.33, + 2942.568, + 2693.304, + 315.54399999999987 + ], + "priority": 38, + "parents": [ + 68449 + ], + "children": [], + "area": 18012429.77544, + "iscrowd": 0, + "segmentation": [], + "text": "Different approach to developing game playing agents\n\nVast majority of game Al research relies on data obtained directly from the game engine. Although the scope of knowledge received this way is often\nartificially limited for fairness, it is still far mO6ré precise and detailed than what is available to human player. Another less commen, approach is to train an\nauto-encoder or artificial neural network*On Screenshots of the game. It is a valid solution shown to work on many different\\gatries, however in this case\nvisual processing and game Al are fusediinto a ‘black box’ which outputs control commands. We attempt to solve this*problem in a slightly more realistic\nscenario - with variable processing/times; uncertain and incomplete knowledge of the scene and delays introduced{by*the control and screen grabbing" + }, + { + "id": 68460, + "strid": "e04494f4-7d19-4744-a44e-06086127e3fa", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 6115.9, + 3376.559, + 771.1549999999997, + 185.6199999999999 + ], + "priority": 39, + "parents": [ + 68449 + ], + "children": [], + "area": 20650697.1881, + "iscrowd": 0, + "segmentation": [], + "text": "COMING SOON..:\n\nWe are working on ytehing the algorithm\nto other similar games, e.g. Robot Unicorn\nAttack." + }, + { + "id": 68465, + "strid": "e2b33177-8c6b-4e81-8dca-aebb1eb3889a", + "image_id": 203178, + "image_name": "119821.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 6209.343, + 3606.036, + 579.9340000000002, + 430.808 + ], + "priority": 40, + "parents": [ + 68449 + ], + "children": [], + "area": 22391114.394348, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 125270, + "strid": "0d1d6cc7-1610-4cc8-8ed0-eb157a7b992f", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 576.31, + 123.93, + 348.6400000000001, + 328.53 + ], + "priority": -1, + "parents": [], + "children": [ + 125244, + 125232, + 125234, + 125264, + 125248, + 125259, + 125246, + 125230, + 125250, + 125241, + 125252, + 125266, + 125268, + 125231 + ], + "area": 71422.0983, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 125230, + "strid": "dd1126f5-7186-4f07-9732-258971444a5b", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 1223.072, + 55.498, + 2363.1219999999994, + 276.485 + ], + "priority": 1, + "parents": [ + 125270 + ], + "children": [], + "area": 67878.049856, + "iscrowd": 0, + "segmentation": [], + "text": "Effect of Wildfire on Plant Growth-Promoting\nRhizobacteria at Getty View Park" + }, + { + "id": 125231, + "strid": "3b2fcd41-3a87-4509-a5e8-fd64d747e767", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1276.581, + 336.592, + 2248.152, + 209.736 + ], + "priority": 2, + "parents": [ + 125270 + ], + "children": [], + "area": 429686.951952, + "iscrowd": 0, + "segmentation": [], + "text": "Jonathan Marin, Danilene Prodon, Thomas Rodriguez, Samuel Wu, Christopher Dao,\nDr. Kris Reddi, Dr. Amanda C. Freise\nDepartment of Microbiology, Immunology, and Molecular Genetics at UCLA" + }, + { + "id": 125232, + "strid": "7e54012c-999a-4451-8b98-ac36b07049ea", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 556.432, + 638.068, + 230.606, + 54.14599999999996 + ], + "priority": 3, + "parents": [ + 125270 + ], + "children": [ + 125233 + ], + "area": 355041.453376, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 125233, + "strid": "d5ac1446-157e-4671-8c44-30f581b728fe", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 51.835, + 726.54, + 1271.295, + 982.568 + ], + "priority": 4, + "parents": [ + 125232 + ], + "children": [], + "area": 37660.200899999996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 125246, + "strid": "38eb77ab-290d-47b2-83d5-b5d03166ba00", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 508.748, + 1859.66, + 338.26900000000006, + 55.1579999999999 + ], + "priority": 5, + "parents": [ + 125270 + ], + "children": [ + 125247 + ], + "area": 946098.30568, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 125247, + "strid": "dd782cc2-07ac-4414-88fe-9f5942702e9d", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 20.246, + 1952.403, + 1316.575, + 522.0199999999998 + ], + "priority": 6, + "parents": [ + 125246 + ], + "children": [], + "area": 39528.351138, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 125248, + "strid": "9fb93bb1-3d6e-4c5e-a2f4-97b61eb8c906", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 143.44, + 2509.684, + 1069.32, + 69.71300000000019 + ], + "priority": 7, + "parents": [ + 125270 + ], + "children": [ + 125249 + ], + "area": 359989.07296, + "iscrowd": 0, + "segmentation": [], + "text": "Hypothesis: long term recovery’s effect" + }, + { + "id": 125249, + "strid": "ae02b868-38e6-4aeb-8328-96c092f27fd8", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 27.652, + 2603.203, + 1300.009, + 416.1579999999999 + ], + "priority": 8, + "parents": [ + 125248 + ], + "children": [], + "area": 71983.769356, + "iscrowd": 0, + "segmentation": [], + "text": "SINCE bacteria and plants have been shown to have a dynamic role in the growth\nand health of each other (Andrew et. al 2012, Minaxi et. Al 2012), and given that\nfire is known to alter environmental conditions (Tas et al. 2014),\n\nIF the bacteria in the Getty View Park have been adapted to the new\nenvironment and will aide in the re-establishment of plants that favors a better\nenvironment,\n\nTHEN there will be an increase in the bacteria and genes that display or assist\nplant growth promoting (PGP) factors near the new plants when compared to\nprevious year or areas without plants." + }, + { + "id": 125250, + "strid": "058c87a4-99e6-4b4b-afed-073b86c88db0", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 556.229, + 3070.79, + 245.74, + 56.5630000000001 + ], + "priority": 9, + "parents": [ + 125270 + ], + "children": [ + 125251 + ], + "area": 1708062.4509100001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 125251, + "strid": "68a66ceb-c34c-4dbd-b2a9-58e982735f08", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 11.637, + 3147.492, + 1322.529, + 1036.4580000000005 + ], + "priority": 10, + "parents": [ + 125250 + ], + "children": [], + "area": 36627.36440400001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 125234, + "strid": "a9ba8040-87e9-4acf-bf1f-4b0eb5fb8ea7", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1662.665, + 642.305, + 1480.087, + 67.50400000000002 + ], + "priority": 11, + "parents": [ + 125270 + ], + "children": [ + 125236, + 125235, + 125237 + ], + "area": 1067938.042825, + "iscrowd": 0, + "segmentation": [], + "text": "Community ability to fix nitrogen relatively unchanged" + }, + { + "id": 125235, + "strid": "d7c654ac-fc9a-4aea-ad43-b410702d6c91", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1325.701, + 857.955, + 639.3220000000001, + 482.4329999999999 + ], + "priority": 12, + "parents": [ + 125234 + ], + "children": [ + 125238 + ], + "area": 1137391.8014550002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 125238, + "strid": "573855f2-4603-43c3-99c3-b730444d2dd5", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1370.251, + 1524.18, + 1020.1520000000003, + 187.26800000000003 + ], + "priority": 13, + "parents": [ + 125235 + ], + "children": [], + "area": 2088509.16918, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1a: Sample photos of JMV/DF media test to determine\nnitrogen fixation capabilities. All isolates grew on the more\npermissive JMV media, and DF media was used to determine\nmore accurately the ability of the isolates to fix nitrogen." + }, + { + "id": 125236, + "strid": "327d16cc-665c-47c0-abbc-e56909f8f294", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1906.19, + 916.789, + 485.04800000000023, + 320.31500000000005 + ], + "priority": 14, + "parents": [ + 125234 + ], + "children": [ + 125239 + ], + "area": 1747574.02391, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 125239, + "strid": "16143dd0-3e57-4b4b-86b6-e2578e242451", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1373.275, + 1712.314, + 1014.7559999999999, + 134.7639999999999 + ], + "priority": 15, + "parents": [ + 125236 + ], + "children": [], + "area": 2351478.0083500003, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1b: Counts chart of isolate performance on DF Nitrogen\nFree media. Isolate trials were repeated in triplicates, with\nrecorded data being the consensus of the three trials." + }, + { + "id": 125237, + "strid": "ec160ab4-d0c9-4b33-ab3f-45a25eff321e", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2396.109, + 725.462, + 1060.7040000000002, + 864.778 + ], + "priority": 16, + "parents": [ + 125234 + ], + "children": [ + 125240 + ], + "area": 1738286.027358, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 125240, + "strid": "37c7fb78-cfb0-4642-9ced-29453fb3ed56", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2401.632, + 1593.288, + 1027.091, + 242.30700000000002 + ], + "priority": 17, + "parents": [ + 125237 + ], + "children": [], + "area": 3826491.446016, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2: All inferred genes encoding for proteins involved in nitrogen\nfixation returned biologically irrelevant results. STAMP calculated the p-\nvalues of the difference in mean proportions of the data. Only one gene,\nnifA, a nitrogenase-specific regulatory protein returned a statistically\nsignificant difference in mean (pvalue=0.049, n=22). This difference was\ndetermined to not be biologically relevant." + }, + { + "id": 125252, + "strid": "138e9271-7b43-4e53-9d9b-90343da164a0", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1533.151, + 1897.956, + 1727.9440000000002, + 66.3409999999999 + ], + "priority": 18, + "parents": [ + 125270 + ], + "children": [ + 125253, + 125254, + 125255 + ], + "area": 2909853.139356, + "iscrowd": 0, + "segmentation": [], + "text": "Community ability to solubilize phosphate relatively unchanged" + }, + { + "id": 125253, + "strid": "67d78b6f-8601-4f1b-bfce-31cb093daae7", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1393.71, + 1991.288, + 380.74199999999996, + 402.29399999999987 + ], + "priority": 19, + "parents": [ + 125252 + ], + "children": [ + 125256 + ], + "area": 2775277.99848, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 125256, + "strid": "128cbe21-3463-4a27-8bb9-b0667f098af0", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1387.975, + 2417.811, + 1032.105, + 114.4079999999999 + ], + "priority": 20, + "parents": [ + 125253 + ], + "children": [], + "area": 3355861.2227249998, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3a: PVK trial 2 for isolates W19UCLA1091BGOM30R10-13. Trials\nwere completed in a 3-replicate series, with the index assigned as the\naverage of the three replicate trials." + }, + { + "id": 125254, + "strid": "30275981-01aa-4cc9-9d2f-5dae431d7f90", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1775.749, + 1992.82, + 583.1009999999999, + 397.41099999999983 + ], + "priority": 21, + "parents": [ + 125252 + ], + "children": [ + 125257 + ], + "area": 3538748.12218, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 125257, + "strid": "e3e40a52-b4fb-4451-9e86-59cb7c53f68b", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1386.794, + 2537.498, + 1032.91, + 319.0459999999998 + ], + "priority": 22, + "parents": [ + 125254 + ], + "children": [], + "area": 3518987.0014120005, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3b: Counts for phosphate solubilization assay | demonstrated\napproximately 97 percent of isolates could solubilize phosphate. Isolates\nwere inoculated on special PVK plates to show clearings if phosphate was\nutilized. Plates were removed and checked for a zone of clearance. From\nthis clearance, a standardized “solubilization index” was calculated, dividing\nthe diameter of the colony plus clearance by the diameter of solely the\ncolony. The only isolate unable to produce a clearing on the plate was\nW19UCLA1091BGOM30R07. Indices were plotted." + }, + { + "id": 125255, + "strid": "96d960a3-f7ad-4613-9ad8-0c2d9ec641ec", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2360.681, + 1983.568, + 1062.297, + 539.6389999999999 + ], + "priority": 23, + "parents": [ + 125252 + ], + "children": [ + 125258 + ], + "area": 4682571.289808, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 125258, + "strid": "dbdddef9-09c5-46af-8fb5-c9d7fbdcd728", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2423.639, + 2539.274, + 997.685, + 318.28600000000006 + ], + "priority": 24, + "parents": [ + 125255 + ], + "children": [], + "area": 6154283.498086, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 4: All inferred genes encoding for proteins involved in phosphate\nsolubilization returned biologically irrelevant results. After filtering for\nall KEGG inferred genes encoding non-metabolism related phosphotases,\nSTAMP calculated the p-values of the difference in mean proportions of\nthe data. Only one gene, appA 4-phytase/acid phosphotase returned a\nstatistically significant difference in mean (pvalue=4.7e-6, n=22). This\ndifference was determined to not be biologically relevant. It should be\nnoted that the differences in mean proportions trended up." + }, + { + "id": 125259, + "strid": "041fc7bd-d5fd-418f-8ad3-08eeafea1269", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1477.804, + 2885.91, + 1837.335, + 161.31899999999996 + ], + "priority": 25, + "parents": [ + 125270 + ], + "children": [ + 125260, + 125261 + ], + "area": 4264809.34164, + "iscrowd": 0, + "segmentation": [], + "text": "Collection time was not a biologically relevant factor in known PGP\nspecies increase according to metagenomic analyses" + }, + { + "id": 125260, + "strid": "56b24ccb-4295-4504-aed3-a5b4bf7af15f", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1338.702, + 3054.559, + 1019.6949999999999, + 882.393 + ], + "priority": 26, + "parents": [ + 125259 + ], + "children": [ + 125262 + ], + "area": 4089144.2424180005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 125262, + "strid": "b5924fbf-f3d8-4295-9fe3-38c1a872f8a8", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1386.393, + 3969.016, + 1032.7359999999999, + 197.48600000000033 + ], + "priority": 27, + "parents": [ + 125260 + ], + "children": [], + "area": 5502615.999288, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 5: The average percentage of sequences present in a sample\ncorrelating to Actinobacteria, a phylum known to contain PGP bacteria,\nwas biologically irrelevant between collection times. STAMP was used to\ncollect and calculate the p-value of the difference in mean proportions of\nthe data." + }, + { + "id": 125261, + "strid": "19d3dc06-b1cf-40b7-b366-252cae04d4d8", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2405.995, + 3056.39, + 1036.1710000000003, + 889.7159999999999 + ], + "priority": 28, + "parents": [ + 125259 + ], + "children": [ + 125263 + ], + "area": 7353659.058049999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 125263, + "strid": "a32a0863-8f9c-4ea4-b191-d0519516c01c", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2434.363, + 3971.335, + 999.2019999999998, + 193.45399999999972 + ], + "priority": 29, + "parents": [ + 125261 + ], + "children": [], + "area": 9667670.984605, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 6: The average percentage of sequences present in a sample\ncorrelating to Proteobacteria, a phylum known to contain PGP bacteria,\nwas biologically irrelevant between collection times. STAMP was used\nto collect and calculate the p-value of the difference in mean proportions\nof the data." + }, + { + "id": 125241, + "strid": "d723d466-ba3f-4614-a6e4-a3bcaf8e03ab", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3585.228, + 636.247, + 1078.455, + 150.72699999999998 + ], + "priority": 30, + "parents": [ + 125270 + ], + "children": [ + 125242 + ], + "area": 2281090.559316, + "iscrowd": 0, + "segmentation": [], + "text": "Sequence similarity analysis via MEGA7\nsuggests possible isolate identities" + }, + { + "id": 125242, + "strid": "ca001f36-a4ed-4389-ac43-0645e47388e4", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3519.407, + 802.553, + 1236.5810000000001, + 662.1060000000001 + ], + "priority": 31, + "parents": [ + 125241 + ], + "children": [ + 125243 + ], + "area": 2824510.646071, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 125243, + "strid": "67f3e17a-e999-4cad-ae21-5c3cbb5384ba", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 3482.822, + 1505.797, + 1289.5680000000002, + 224.673 + ], + "priority": 32, + "parents": [ + 125242 + ], + "children": [], + "area": 5244422.919134, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 7: BLASTn and RDP Il nearest-neighbor produced phylogenetic tree.\nOnce sequences were clarified post-Sanger sequencing, BLASTn and RDPII were\nused to find nearest neighbor sequences. STAMP was used to construct a\nphylogenetic tree using the neighbor joining tree and a bootstrap replicates of\nOe" + }, + { + "id": 125244, + "strid": "1fc76446-1b51-43b2-9614-c8291e244610", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3964.75, + 1740.369, + 327.5770000000002, + 53.2650000000001 + ], + "priority": 33, + "parents": [ + 125270 + ], + "children": [ + 125245 + ], + "area": 6900127.992749999, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 125245, + "strid": "1b34af11-8d7c-4d49-888a-21d20c8b8930", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3475.849, + 1832.511, + 1300.5239999999994, + 758.1700000000001 + ], + "priority": 34, + "parents": [ + 125244 + ], + "children": [], + "area": 6369531.526839, + "iscrowd": 0, + "segmentation": [], + "text": "Nitrogen Fixation: Although there is presence of nitrogen fixing bacteria within\nthe sample, metagenomic analysis showed little difference in nitrogen fixing\ngenes between one month post-fire and one year post-fire.\n\nPhosphate Solubilization: Similarly, the presence of bacteria able to solubilize\nphosphorus in the soil did not reflect a significant increase in bacteria or genes\nknown to be associated with phosphate solubilization.\n\nCommunity Profile: While there was a slight change in various phyla of bacteria\nassociated with plant growth-promoting properties, these changes were not\nstatistically significant. The change in Proteobacteria and Actinobacteria was not\nstatistically significant across samples even though they did have a slight\nincrease one year post-fire.\n\nIsolate Sequencing: The species isolated by our cultivation efforts were found to\nbe highly similar in sequence to some species of Bacilli and Streptomyces, two\ngenera known to contain PGP species. One isolate was found to associate with\nE.coli but the outgroup who they grouped with does not share identity even at\nthe phylum level." + }, + { + "id": 125264, + "strid": "293e5d45-67fb-4455-81bb-3bf80c361db6", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3894.666, + 2630.169, + 474.70899999999983, + 53.80000000000018 + ], + "priority": 35, + "parents": [ + 125270 + ], + "children": [ + 125265 + ], + "area": 10243629.778554, + "iscrowd": 0, + "segmentation": [], + "text": "Future Directions" + }, + { + "id": 125265, + "strid": "a160247d-512d-4f3a-8bdf-7ba7edfc6ef2", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3484.082, + 2716.972, + 1296.1870000000004, + 429.00999999999976 + ], + "priority": 36, + "parents": [ + 125264 + ], + "children": [], + "area": 9466153.239704, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 125266, + "strid": "70e168a9-db71-4fc5-962c-d10a2e910023", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3857.351, + 3197.331, + 539.1169999999997, + 69.41400000000021 + ], + "priority": 37, + "parents": [ + 125270 + ], + "children": [ + 125267 + ], + "area": 12333227.930181, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements" + }, + { + "id": 125267, + "strid": "002034ac-017f-4402-af8c-04700f71ae16", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3485.167, + 3294.031, + 1286.681, + 277.7930000000001 + ], + "priority": 38, + "parents": [ + 125266 + ], + "children": [], + "area": 11480248.138177, + "iscrowd": 0, + "segmentation": [], + "text": "Thank you to Louise and Alan for providing guidance throughout MIMG 109AL &\nMIMG 109BL, CaleDNA for providing us resources to conduct our metagenomic\nanalysis, and the Dean of the Life Sciences Division for providing the funding to\nobtain the resources necessary to conduct our research.\n\nThank you as well to the teaching and learning assistants associated with the\nMIMG 109L series." + }, + { + "id": 125268, + "strid": "321e3f38-e18a-4277-9e8c-bfa43deb779c", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3981.321, + 3623.077, + 300.33399999999983, + 55.72200000000021 + ], + "priority": 39, + "parents": [ + 125270 + ], + "children": [ + 125269 + ], + "area": 14424632.544717, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 125269, + "strid": "c048f9d6-a8f7-4957-8308-d50b16ebb587", + "image_id": 205376, + "image_name": "15001.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3480.707, + 3714.21, + 1281.1919999999996, + 484.0060000000003 + ], + "priority": 40, + "parents": [ + 125268 + ], + "children": [], + "area": 12928076.74647, + "iscrowd": 0, + "segmentation": [], + "text": "Andrew, David R., Robert R. Fitak, Adrian Munguia-Vega, Adriana Racolta, Vincent G. Martison, and Katerina Dontsova.\n“Abiotic Factors Shape Microbial Diversity in Sonoran Desert Soil.” Applied and Environmental Microbiology, vol. 78, no. 21,\n2012, pp. 7527-7537., doi:10.1128/aem.01459-12.\n\nBerlemont, Renaud, Steven D. Allison, Claudia Weihe, Ying Lu, Eoin L. Brodie, Jennier B. H. Martiny and Adam C. Martiny.\n“Cellulolytic Potential under Environmental Changes in Microbial Communities from Grassland Litter.” Frontiers in\nMicrobiology, vol. 5, 2014, doi:10:3389/fmicb.2014.00639.\n\nDavis, Kimberley T., et al. \"Wildfires and climate change push low-elevation forests across a critical climate threshold for tree\nregeneration.\" Proceedings of the National Academy of Sciences116.13 (2019): 6193-6198.\n\nDeBano, Leonard F. 1989. Effects of fire on chaparral soils in Arizona and California and postfire management implications. In:\nBerg, N., ed. Fire and watershed management: symposium proceedings; 1988 October 16-28; Sacramento, CA. Gen. Tech.\nRep.\n\nPSW-109. Berkeley, CA: U.S. Department of Agriculture, Forest Service, Pacific Southwest Forest and Range Experiment\nStation: 55-62.\n\nMinaxi, Lata Nain, Yadav R.C., Jyoti Saxena. “Characterization of Multifacted Bacillus Sp. RM-2 for Its use as Plant Growth\nPromoting Bioinoculant for Crops Grown in Semi Arid Deserts.” Applied Soil Ecology, vol. 59, 2012, pp. 124-135, doi:\n10.1016/j.apsoil.2011.08.001." + }, + { + "id": 134939, + "strid": "b407e16e-3f79-41dc-8baa-94ec170854d8", + "image_id": 205732, + "image_name": "15765.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 72.36, + 26.54, + 53.07000000000001, + 58.12 + ], + "priority": -1, + "parents": [], + "children": [ + 134910, + 134913, + 134909, + 134911, + 134907, + 134908, + 134912, + 134906, + 134914, + 134905 + ], + "area": 1920.4343999999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 134905, + "strid": "047f2dd6-8b7d-4b6d-a18a-538eda08e050", + "image_id": 205732, + "image_name": "15765.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 88.663, + 105.512, + 648.383, + 23.828000000000003 + ], + "priority": 1, + "parents": [ + 134939 + ], + "children": [], + "area": 9355.010456, + "iscrowd": 0, + "segmentation": [], + "text": "Differential Expression Analysis with Latent Variable Models" + }, + { + "id": 134906, + "strid": "d92ec93c-8902-4ca3-9f25-1174f017a0d8", + "image_id": 205732, + "image_name": "15765.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 37.866, + 131.173, + 684.059, + 46.739000000000004 + ], + "priority": 2, + "parents": [ + 134939 + ], + "children": [], + "area": 4966.996818, + "iscrowd": 0, + "segmentation": [], + "text": "Jeana Godinho!, Alexandra M. Carvalho’, Susana Vinga’*\n\n*IST, Universidade de Lisboa; *INESC-ID, IST, Universidade de Lisboa; “Instituto de Tolecomunicagées, IST, Universidade de Lisboa:" + }, + { + "id": 134907, + "strid": "7e036657-c144-42c7-b3e4-f23029bce8d4", + "image_id": 205732, + "image_name": "15765.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 39.37, + 186.361, + 112.65199999999999, + 30.05600000000001 + ], + "priority": 3, + "parents": [ + 134939 + ], + "children": [ + 134923 + ], + "area": 7337.032569999999, + "iscrowd": 0, + "segmentation": [], + "text": "| Abstract" + }, + { + "id": 134923, + "strid": "87093ed4-8add-448a-af64-23b7ef455dbe", + "image_id": 205732, + "image_name": "15765.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 55.666, + 213.47, + 354.204, + 157.65900000000002 + ], + "priority": 4, + "parents": [ + 134907 + ], + "children": [], + "area": 11883.02102, + "iscrowd": 0, + "segmentation": [], + "text": "wn lie Ted Ot mores Boteay genomic slovstiee Suaies is & powerul ese eee\ncbscures celular aspect One of the man lasks in genomic sinstire analysis the\nexporter of wacom dt, wih enae he recap ot gas ee eral\noxessed (OES)\n\nDaas sling treatment developer nt the deniaion af raw al populons sesame\nothe rat relevant apicson tal lyon DEG keiaion Inte cote, tee al\ntcolgjesemergn, rary ONA merous: but NA somuneing AN seg) ane sle\ncall NA saquareing(eFWA-eq), te focus of the ak. Alfwigh tends o ole mor\nSecure aa han heater ho, Sito by mary coroundng cers\n\nWe taduce two novel sproches lo peo DEG tarieson ver anglecal daa. Sth\necnuce rly on ler! varie made to aceon tar he mlescng factors presen in he\ndoa In aon. we torchmack the popored tos nih Hrown GEG deletion lol\nsige dia, sch au SCDE and WAST To 0 wo uted io pu rel dla a ae\nSeon used pat asensmensk.\n\nThe eaute lied show thal the two proceduee can be very compte wih caren\nTe results Obiained show thal the two proce" + }, + { + "id": 134909, + "strid": "a916bbb1-fe88-47ae-9678-fd806e16b5f1", + "image_id": 205732, + "image_name": "15765.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 43.008, + 388.002, + 156.43, + 30.53000000000003 + ], + "priority": 5, + "parents": [ + 134939 + ], + "children": [ + 134936, + 134937 + ], + "area": 16687.190016, + "iscrowd": 0, + "segmentation": [], + "text": "D \\|ntroduction" + }, + { + "id": 134937, + "strid": "080aff2a-2c08-4e63-9e1c-7342fd2e4207", + "image_id": 205732, + "image_name": "15765.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 69.023, + 421.833, + 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"children": [], + "area": 300258.0644, + "iscrowd": 0, + "segmentation": [], + "text": "method considering 50 runs of DE\narate Selvech Ban Oona\ncl PMc dase) ey" + }, + { + "id": 134933, + "strid": "d2e754a7-cedf-4c63-b7f2-3a043bd29cd5", + "image_id": 205732, + "image_name": "15765.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 441.721, + 547.651, + 363.534, + 246.94299999999998 + ], + "priority": 26, + "parents": [ + 134908 + ], + "children": [ + 134919 + ], + "area": 241908.947371, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 134919, + "strid": "caee67ca-3ffc-4433-b322-f635005486c5", + "image_id": 205732, + "image_name": "15765.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 457.641, + 799.092, + 328.973, + 28.69500000000005 + ], + "priority": 27, + "parents": [ + 134933 + ], + "children": [], + "area": 365697.261972, + "iscrowd": 0, + "segmentation": [], + "text": "BNA can DiNBeree wel and SCOE nthe cron ott nan har Deseo on MAST Boch\nSIENA. ext-ZINBayes,scVl ant SCDE an the score ot 1 tun for DEseq and MAST. Each\nSunnie ae" + }, + { + "id": 134917, + "strid": "5a2f832f-bbfc-4cbd-b490-5301e7598cd8", + "image_id": 205732, + "image_name": "15765.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 436.042, + 836.622, + 362.421, + 25.399999999999977 + ], + "priority": 28, + "parents": [ + 134908 + ], + "children": [], + "area": 364802.330124, + "iscrowd": 0, + "segmentation": [], + "text": "Time: WE the islam dataset, DEseq takes 250, scVl Imind7s, MAST imingde,\nSIENA 1minSSs, ext-ZINBayes 2min58s and finally SCDE takes 5min22s." + }, + { + "id": 134912, + "strid": "2b9553c7-a8e7-46c8-a9aa-30dbdd4152b6", + "image_id": 205732, + "image_name": "15765.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 436.817, + 885.34, + 184.57899999999995, + 31.071000000000026 + ], + "priority": 29, + "parents": [ + 134939 + ], + "children": [ + 134915 + ], + "area": 386731.56278000004, + "iscrowd": 0, + "segmentation": [], + "text": "6 Final Remarks" + }, + { + "id": 134915, + "strid": "f85729cf-6c73-4d35-8fdb-8a962f3d6b6b", + "image_id": 205732, + "image_name": "15765.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 452.527, + 922.699, + 329.83099999999996, + 53.17100000000005 + ], + "priority": 30, + "parents": [ + 134912 + ], + "children": [], + "area": 417546.21037299995, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 134913, + "strid": "797e676b-c6e9-49db-94ea-d1235bac2a6d", + "image_id": 205732, + "image_name": "15765.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 435.509, + 1000.046, + 226.27499999999998, + 29.689000000000078 + ], + "priority": 31, + "parents": [ + 134939 + ], + "children": [ + 134918 + ], + "area": 435529.03341400006, + "iscrowd": 0, + "segmentation": [], + "text": "/ Acknowledgments" + }, + { + "id": 134918, + "strid": "f12f8773-7eb8-4e71-8e32-1a1d77c065f8", + "image_id": 205732, + "image_name": "15765.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 451.127, + 1034.06, + 312.98999999999995, + 21.585000000000036 + ], + "priority": 32, + "parents": [ + 134913 + ], + "children": [], + "area": 466492.38561999996, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 134914, + "strid": "1f2f134a-90a1-41dd-9886-9917a7770dec", + "image_id": 205732, + "image_name": "15765.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 437.576, + 1075.063, + 151.35300000000007, + 31.4079999999999 + ], + "priority": 33, + "parents": [ + 134939 + ], + "children": [ + 134916 + ], + "area": 470421.7672880001, + "iscrowd": 0, + "segmentation": [], + "text": "® References" + }, + { + "id": 134916, + "strid": "b7fc6baf-4eb0-4ded-b63c-64bae83496a6", + "image_id": 205732, + "image_name": "15765.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 446.023, + 1111.753, + 361.74799999999993, + 22.298999999999978 + ], + "priority": 34, + "parents": [ + 134914 + ], + "children": [], + "area": 495867.408319, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 188081, + "strid": "4cc834e2-d906-4271-9ae4-b0d3a2d247c3", + "image_id": 207836, + "image_name": "8869.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 47.52, + 18.98, + 402.29, + 80.46 + ], + "priority": -1, + "parents": [], + "children": [ + 188077, + 188073, + 188078, + 188074, + 188076, + 188072, + 188071 + ], + "area": 901.9296, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 188071, + "strid": "6b460f96-1772-4a98-843b-abd9ba945744", + "image_id": 207836, + "image_name": "8869.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 383.469, + 545.039, + 2314.117, + 179.96299999999997 + ], + "priority": 1, + "parents": [ + 188081 + ], + "children": [], + "area": 209005.560291, + "iscrowd": 0, + "segmentation": [], + "text": "Science in the Clouds: Virtualizing HADDOCK, PowerFit\nand DisVis using INDIGO-DataCloud Solutions" + }, + { + "id": 188072, + "strid": "ed9021f1-a36f-440b-b233-4300fa6cf1f7", + "image_id": 207836, + "image_name": "8869.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 610.011, + 756.761, + 2199.788, + 165.14300000000003 + ], + "priority": 2, + "parents": [ + 188081 + ], + "children": [], + "area": 461632.53437099996, + "iscrowd": 0, + "segmentation": [], + "text": "Zeynep Kurkcuoglu and A.M.J.J. Bonvin\nFaculty of Science -— Chemistry, Bijvoet Center, Utrecht University (The Netherlands)" + }, + { + "id": 188073, + "strid": "965bb3b6-3609-476c-8d01-05ff3e57453d", + "image_id": 207836, + "image_name": "8869.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 136.36, + 1059.523, + 282.8, + 36.29500000000007 + ], + "priority": 3, + "parents": [ + 188081 + ], + "children": [ + 188079, + 188075 + ], + "area": 144476.55628, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 188075, + "strid": "7b90e1e7-1975-45e0-b452-376a876809f4", + "image_id": 207836, + "image_name": "8869.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 135.953, + 1105.597, + 969.405, + 1603.0759999999998 + ], + "priority": 4, + "parents": [ + 188073 + ], + "children": [], + "area": 150309.228941, + "iscrowd": 0, + "segmentation": [], + "text": "Reliable bioinformatics and computational\nmethods are needed for complementing\nexperimental techniques, to study structure-\ndynamics-interactions of biomolecular machines\nat atomistic level.\n\nAccordingly, we have developed HADDOCK [1],\nour integrative, information-driven approach for\nmodelling biomolecular complexes. Access to\nHADDOCK is offered to more than 6500 users\nworldwide through a user-friendly web interface\n[2], offered both on local sources and\nworldwide distributed grid resources within\nWeNMR Virtual Research Community [3].\nPowerFit [4] and DisVis [5] are two other\nsoftwares recently developed by our group, for\nautomatic rigid body fitting of biomolecular\nstructures in Cryo-EM densities and for\nvisualization and quantification of the accessible\ninteraction space of distance restrained binary\nbiomolecular complexes, respectively.\n\nWithin the European H2020 INDIGO-DataCloud\nproject (INtegrating Distributed data\nInfrastructures for Global ExplOitation) we aim\nat virtualizing the HADDOCK portal, together\nwith PowerFit and DisVis. The use of eScience\nCLOUD solutions will decrease the dependency\non local hardware and also facilitate the\ndeployment, configuration and customization of\nthese softwares. This will in turn allow the end\nusers to conduct scientific research without the\ndistraction of technical details at software-\nhardware level." + }, + { + "id": 188079, + "strid": "78865bbd-b4d8-48dd-897e-bbc9284b9cdf", + "image_id": 207836, + "image_name": "8869.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1125.954, + 1039.434, + 1975.731, + 1663.773 + ], + "priority": 5, + "parents": [ + 188073 + ], + "children": [], + "area": 1170354.870036, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 188078, + "strid": "e2ea8281-02d1-4fdf-a508-f1bc1d848b2c", + "image_id": 207836, + "image_name": "8869.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 164.872, + 2854.459, + 2763.502, + 885.4549999999999 + ], + "priority": 6, + "parents": [ + 188081 + ], + "children": [], + "area": 470620.364248, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 188076, + "strid": "220aa41f-ad04-48c4-8646-b0205b23a8fb", + "image_id": 207836, + "image_name": "8869.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 465.486, + 3818.061, + 1049.312, + 281.7069999999999 + ], + "priority": 7, + "parents": [ + 188081 + ], + "children": [], + "area": 1777253.942646, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 188077, + "strid": "40332ce9-560f-4eff-89f7-1dacf071148d", + "image_id": 207836, + "image_name": "8869.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1609.33, + 3833.186, + 1331.0190000000002, + 139.9079999999999 + ], + "priority": 8, + "parents": [ + 188081 + ], + "children": [], + "area": 6168861.22538, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 188074, + "strid": "74b252fd-faa4-41cf-a805-4eec7ff821c9", + "image_id": 207836, + "image_name": "8869.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 117.519, + 4145.596, + 208.47500000000002, + 32.04100000000017 + ], + "priority": 9, + "parents": [ + 188081 + ], + "children": [ + 188080 + ], + "area": 487186.296324, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 188080, + "strid": "f6f5a81e-35e1-4f49-9a82-041437d19863", + "image_id": 207836, + "image_name": "8869.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 117.774, + 4191.76, + 1324.2400000000002, + 322.5169999999998 + ], + "priority": 10, + "parents": [ + 188074 + ], + "children": [], + "area": 493680.34224, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 153690, + "strid": "fc30fc49-e227-4f77-8019-c73d44a50c8e", + "image_id": 206487, + "image_name": "22022.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 93.79, + 16.69, + 402.28999999999996, + 40.22 + ], + "priority": -1, + "parents": [], + "children": [ + 153688, + 153674, + 153670, + 153671, + 153669, + 153672, + 153676, + 153673, + 153675 + ], + "area": 1565.3551000000002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 153669, + "strid": "16fef21e-40d5-477a-85d8-2bfaee962da6", + "image_id": 206487, + "image_name": "22022.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 84.179, + 90.746, + 2818.692, + 239.37100000000004 + ], + "priority": 1, + "parents": [ + 153690 + ], + "children": [], + "area": 7638.907534, + "iscrowd": 0, + "segmentation": [], + "text": "Copy number-aware methylation deconvolution analysis\nof cancers using whole genome bisulfite sequencing data" + }, + { + "id": 153670, + "strid": "e8ff52f9-a786-4aa9-9e48-4333e8c1ef1e", + "image_id": 206487, + "image_name": "22022.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 69.133, + 371.498, + 2822.221, + 239.79199999999997 + ], + "priority": 2, + "parents": [ + 153690 + ], + "children": [], + "area": 25682.771233999996, + "iscrowd": 0, + "segmentation": [], + "text": "Nana Mensah'”, Elizabeth Larose Cadieux'”, Tom Lesluyes', Jonas Demeulemeester'?, Stephan Beck’, Peter Van Loo'*\n1. The Francis Crick Institute, London, United Kingdom\n\n2. University College London, London, United Kingdom\n\n3. University of Leuven, Leuven, Belgium\n\n4. The University of Texas MD Anderson Cancer Center, Texas, United States" + }, + { + "id": 153671, + "strid": "77fe510b-1dc0-4ac5-95f2-99fcd1bd2379", + "image_id": 206487, + "image_name": "22022.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 103.196, + 650.579, + 210.79300000000003, + 32.41100000000006 + ], + "priority": 3, + "parents": [ + 153690 + ], + "children": [ + 153677 + ], + "area": 67137.150484, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 153677, + "strid": "89e01527-7ab2-4f2f-88ef-6d4b399397c7", + "image_id": 206487, + "image_name": "22022.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 71.167, + 735.658, + 614.748, + 831.0559999999999 + ], + "priority": 4, + "parents": [ + 153671 + ], + "children": [], + "area": 52354.572886, + "iscrowd": 0, + "segmentation": [], + "text": "Aberrant DNA methylation is a\nfeature of metastatic castration\nresistant prostate cancer (mCRPC)\n[1]. Whole genome bisulfite\nsequencing (WGBS) of bulk tumors\nreveals DNA methylation § at\nbase-pair resolution, however\ntumor methylation signals are\nconfounded by varying purity and\nploidy. We developed CAMDAC to\naddress these confounders [2] and\npresent an extention of this\nmethod for WGBS analysis. Applied\nto mCRPC_ samples, CAMDAC\npurifies bulk tumor methylation\nand offers new opportunities to\ninterrogate epigenetic disruption\nin cancer evolution." + }, + { + "id": 153672, + "strid": "3d641723-7b77-4b71-acbf-a37dadac67fe", + "image_id": 206487, + "image_name": "22022.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 763.109, + 647.697, + 129.35199999999998, + 33.928 + ], + "priority": 5, + "parents": [ + 153690 + ], + "children": [ + 153678 + ], + "area": 494263.409973, + "iscrowd": 0, + "segmentation": [], + "text": "Method" + }, + { + "id": 153678, + "strid": "f6ecf0b0-99cd-4cee-bb47-6bb652aeb180", + "image_id": 206487, + "image_name": "22022.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 729.396, + 718.735, + 2484.932, + 751.9020000000002 + ], + "priority": 6, + "parents": [ + 153672 + ], + "children": [ + 153679 + ], + "area": 524242.43406, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 153679, + "strid": "58f505e1-aa5f-40ff-9da4-3ef2490a6937", + "image_id": 206487, + "image_name": "22022.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 739.081, + 1513.275, + 2412.874, + 64.75099999999998 + ], + "priority": 7, + "parents": [ + 153678 + ], + "children": [], + "area": 1118432.800275, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. Overview of the CAMDAC workflow. WGBS data was acquired from 93 patients with mCRPC enrolled on the Stand Up To Cancer project [1]. Bismark-aligned BAMs were processed using\nCAMDAC. Tumor purity and ploidy were estimated using the Battenberg algorithm, followed by deconvolution using the CAMDAC algorithm to estimate pure-tumor methylation at each CpG site." + }, + { + "id": 153673, + "strid": "c7991620-bc90-425a-a049-e084a085c3c7", + "image_id": 206487, + "image_name": "22022.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 104.993, + 1647.648, + 1369.478, + 40.41300000000001 + ], + "priority": 8, + "parents": [ + 153690 + ], + "children": [ + 153682 + ], + "area": 172991.50646399998, + "iscrowd": 0, + "segmentation": [], + "text": "CAMDAC detects allele-specific copy number abberations concordant with WGS" + }, + { + "id": 153682, + "strid": "783fa907-f5bc-4b6c-9df6-0812e0bf9d3c", + "image_id": 206487, + "image_name": "22022.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 83.03, + 1734.898, + 1559.875, + 1081.3570000000002 + ], + "priority": 9, + "parents": [ + 153673 + ], + "children": [ + 153680 + ], + "area": 144048.58093999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 153680, + "strid": "098622e0-7932-4fef-adc7-7258d9212e4b", + "image_id": 206487, + "image_name": "22022.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 60.267, + 2828.964, + 1583.46, + 165.56500000000005 + ], + "priority": 10, + "parents": [ + 153682 + ], + "children": [], + "area": 170493.173388, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2. A) Bulk tumor methylation at CpGs unmethylated in matched normal tissue. Red line: purity estimates from WGS. B)\nPurity and ploidy estimates from applying CAMDAC to WGBS data alongside estimates from WGS. C) Allele-specific copy number\nconcordance for sample DTB-003 at CNA. Dark grey: Matching major allele, Grey: matching minor allele, Blue: Major allele mis-\nmatch, Red: Minor allele mismatch. D) Allele-specific copy number abberation (CNA) concordance at overlapping CNA segments\nbetween all tumor samples." + }, + { + "id": 153674, + "strid": "e1b33a35-4b33-41c8-b51d-f1e0cc8feb5f", + "image_id": 206487, + "image_name": "22022.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1719.656, + 1650.209, + 847.3940000000002, + 40.23199999999997 + ], + "priority": 11, + "parents": [ + 153690 + ], + "children": [ + 153683 + ], + "area": 2837791.808104, + "iscrowd": 0, + "segmentation": [], + "text": "Pure tumor methylomes cluster by tumor subtype" + }, + { + "id": 153683, + "strid": "4af48d67-a207-47d0-9e8c-208f984f39c7", + "image_id": 206487, + "image_name": "22022.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1787.542, + 1736.439, + 1450.5030000000002, + 1019.7079999999999 + ], + "priority": 12, + "parents": [ + 153674 + ], + "children": [ + 153681 + ], + "area": 3103957.642938, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 153681, + "strid": "3d83b7df-29c6-435c-b779-bccdcf204b94", + "image_id": 206487, + "image_name": "22022.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1676.312, + 2818.407, + 1573.085, + 166.70400000000018 + ], + "priority": 13, + "parents": [ + 153683 + ], + "children": [], + "area": 4724529.4749839995, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 4. A) Hierarchical clustering of DNA methylation profiles from bulk tumor, normal, purified tumor and normal panel\nsamples. Normal panels group with patient-matched normals (cluster 1). Bulk and purified tumor samples group together (clus-\nter 2) with bulk tumors displaying more intermediate methylation, indiciating greater cellular admixture. Once deconvolved,\npure tumors cluster separately from bulk tumors for the same sample, except in the case of DTB-077 due to high purity, and\nDTB-003 driven by its identity as a neuroendocrine tumour." + }, + { + "id": 153675, + "strid": "353654da-d787-409a-811d-f2edefd28a2e", + "image_id": 206487, + "image_name": "22022.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 90.127, + 3046.077, + 1041.317, + 41.164000000000215 + ], + "priority": 14, + "parents": [ + 153690 + ], + "children": [ + 153684 + ], + "area": 274533.781779, + "iscrowd": 0, + "segmentation": [], + "text": "CAMDAC deconvolution reproduces SNV-phased methylation" + }, + { + "id": 153684, + "strid": "fafee75c-4191-4e27-8223-7c1db4b9181b", + "image_id": 206487, + "image_name": "22022.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 69.41, + 3158.688, + 1571.577, + 1027.6229999999996 + ], + "priority": 15, + "parents": [ + 153675 + ], + "children": [ + 153686 + ], + "area": 219244.53407999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 153686, + "strid": "80bb5152-4f9e-4f27-8152-e4a4b9ad81fe", + "image_id": 206487, + "image_name": "22022.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 65.228, + 4226.494, + 1569.985, + 130.82999999999993 + ], + "priority": 16, + "parents": [ + 153684 + ], + "children": [], + "area": 275685.750632, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3. A) Aschematic of the procedure for CAMDAC validation using methylation on SNV-phased reads. B) Bulk and pure\nmethylation at sites with SNV-phasing. MAE: median aboslute error C) Per-sample distribution of CAMDAC-purified methylation\ndistance from SNV-phased methylation at phased CpGs. Barplots (top) display the number of SNV-phased CpGs evaluated for\neach sample." + }, + { + "id": 153676, + "strid": "a0782b63-deee-4adc-a432-e5b8927fddb5", + "image_id": 206487, + "image_name": "22022.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1703.818, + 3046.492, + 1398.9730000000002, + 40.03800000000001 + ], + "priority": 17, + "parents": [ + 153690 + ], + "children": [ + 153685 + ], + "area": 5190667.906456, + "iscrowd": 0, + "segmentation": [], + "text": "Normal methylation panels are similar to patient-matched tissue-matched samples" + }, + { + "id": 153685, + "strid": "363a8478-f724-4d01-9ea4-d49bb35ddfea", + "image_id": 206487, + "image_name": "22022.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1694.91, + 3150.111, + 1587.4549999999997, + 1034.0919999999996 + ], + "priority": 18, + "parents": [ + 153676 + ], + "children": [ + 153687 + ], + "area": 5339154.63501, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 153687, + "strid": "4db9fa63-eafc-4caa-8266-b2c0076ca95b", + "image_id": 206487, + "image_name": "22022.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1704.529, + 4213.48, + 1515.5, + 130.60999999999967 + ], + "priority": 19, + "parents": [ + 153685 + ], + "children": [], + "area": 7181998.850919999, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 5. A) CpG coverage and standard deviation for each normal tissue methylation panel. B) Principal components anal-\nysis reveals sample methylation variance is explained by tumor-normal differences (PC1), prostate samples (PC2), liver\nsamples (PC3) and neuroendocrine tumors (PC4). C) Differential methylation between patient matched normals and a tis-\nsue-matched validation panel. D) Cell type proportions inferred across normal liver samples using EpiSCORE." + }, + { + "id": 153688, + "strid": "2e3fbebf-0341-4f20-93d2-9756ff438085", + "image_id": 206487, + "image_name": "22022.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 90.793, + 4396.255, + 200.21699999999998, + 32.628999999999905 + ], + "priority": 20, + "parents": [ + 153690 + ], + "children": [ + 153689 + ], + "area": 399149.18021500006, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 153689, + "strid": "62be48f0-b603-4ae4-8d01-f1323524cd9f", + "image_id": 206487, + "image_name": "22022.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 53.08, + 4480.369, + 2193.299, + 183.34799999999996 + ], + "priority": 21, + "parents": [ + 153688 + ], + "children": [], + "area": 237817.98651999998, + "iscrowd": 0, + "segmentation": [], + "text": "CAMDAC estimates pure tumor methylation from bulk WGBS data, as demonstrated with the mCRPC dataset. SNV-phased reads\ndemonstrate that CAMDAC-deconvolved methylation rates are superior to bulk methylation. Normal tissue methylation panels\nmay be suitable for deconvolution, dependent on inter-sample cell type composition. Future work will profile the interplay\nbetween CNAs and epigenetic disregulation. CAMDAC is available at https: //github.com/VanLoo-lab/CAMDAC/" + }, + { + "id": 108089, + "strid": "12184192-95d4-4520-9c8d-cef66de500ca", + "image_id": 204688, + "image_name": "12778.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 77.11, + 69.1, + 125.44000000000001, + 109.76000000000002 + ], + "priority": -1, + "parents": [], + "children": [ + 108066, + 108063, + 108065, + 108064, + 108067, + 108087, + 108062 + ], + "area": 5328.3009999999995, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 108062, + "strid": "8f55dd98-1a70-4066-869f-05c928fe6043", + "image_id": 204688, + "image_name": "12778.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 249.58, + 77.591, + 2865.857, + 128.70599999999996 + ], + "priority": 1, + "parents": [ + 108089 + ], + "children": [], + "area": 19365.16178, + "iscrowd": 0, + "segmentation": [], + "text": "PhD Outcomes Tracking and Career Taxonomies" + }, + { + "id": 108063, + "strid": "a36b32b1-a068-4a2a-92fa-f282b6ea5296", + "image_id": 204688, + "image_name": "12778.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 191.662, + 210.588, + 2990.273, + 158.73800000000003 + ], + "priority": 2, + "parents": [ + 108089 + ], + "children": [], + "area": 40361.717256, + "iscrowd": 0, + "segmentation": [], + "text": "Tammy Collins’, Ryan Wheeler’, Adriana Bankston, Melanie Sinche*\n\n’National Institute of Environmental Health Sciences; The Scripps Research Institute; 7Future of Research; ‘The Jackson Laboratory" + }, + { + "id": 108064, + "strid": "1b53bc44-6fd9-4dbc-96dd-558e54855b48", + "image_id": 204688, + "image_name": "12778.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 203.026, + 476.475, + 845.027, + 62.35299999999995 + ], + "priority": 3, + "parents": [ + 108089 + ], + "children": [ + 108068, + 108076, + 108069 + ], + "area": 96736.81335000001, + "iscrowd": 0, + "segmentation": [], + "text": "Collating Career Taxonomies" + }, + { + "id": 108068, + "strid": "68489a46-059d-42eb-8d8f-128c73cebcc1", + "image_id": 204688, + "image_name": "12778.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 86.876, + 548.237, + 1090.103, + 375.57499999999993 + ], + "priority": 4, + "parents": [ + 108064 + ], + "children": [], + "area": 47628.637612, + "iscrowd": 0, + "segmentation": [], + "text": "We collated STEM and humanities career outcome taxonomies\nfrom 22 groups (universities, consortia, research institutions &\nprofessional societies). There was significant overlap\nregarding the classification of employment sectors, with 8\nclear categories (and further sector subdivisions) emerging.\nA key challenge in unifying taxonomies occurs due to the\ndifferent nature of employment sectors between countries.\nFor complete details, take a copy of our handout." + }, + { + "id": 108069, + "strid": "44926f06-d0ea-44f1-9559-a84f7f8291af", + "image_id": 204688, + "image_name": "12778.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 101.707, + 984.395, + 1037.138, + 117.24900000000002 + ], + "priority": 5, + "parents": [ + 108064 + ], + "children": [], + "area": 100119.86226499999, + "iscrowd": 0, + "segmentation": [], + "text": "Eight Clear Employment Sectors Emerged\nAcademic | Government | For-profit | Non-profit | Individual |\n\nUnemployed (seeking employment) | Not in Workforce | Unknown" + }, + { + "id": 108076, + "strid": "a169de88-6452-4f11-884c-e69b14668237", + "image_id": 204688, + "image_name": "12778.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 111.711, + 1128.617, + 986.7749999999999, + 324.95000000000005 + ], + "priority": 6, + "parents": [ + 108064 + ], + "children": [], + "area": 126078.933687, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 108067, + "strid": "e76d8da0-a786-47b7-be70-77c782878bfa", + "image_id": 204688, + "image_name": "12778.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 197.857, + 1493.908, + 847.0140000000001, + 123.32899999999995 + ], + "priority": 7, + "parents": [ + 108089 + ], + "children": [ + 108086, + 108070 + ], + "area": 295580.155156, + "iscrowd": 0, + "segmentation": [], + "text": "Coalition for Next Generation\nLife Science" + }, + { + "id": 108070, + "strid": "e4dc5154-05d9-4eeb-8278-c3db4acaeaab", + "image_id": 204688, + "image_name": "12778.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 86.392, + 1635.873, + 1051.651, + 265.3130000000001 + ], + "priority": 8, + "parents": [ + 108067 + ], + "children": [], + "area": 141326.340216, + "iscrowd": 0, + "segmentation": [], + "text": "The Coalition for Next Generation Life Science seeks to\nimprove transparency and trainee outcomes in the life\nsciences’. A collection of data, resources and other groups\nin addition to GCC (including AAU, AAMC, NIH BEST, NIH.\nCGS, RBR) are listed on the Future of Research website.”" + }, + { + "id": 108086, + "strid": "8617d81e-1a26-4dcc-a646-c83fb2c1f9af", + "image_id": 204688, + "image_name": "12778.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 83.184, + 1913.991, + 1072.049, + 274.076 + ], + "priority": 9, + "parents": [ + 108067 + ], + "children": [], + "area": 159213.427344, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 108065, + "strid": "17edecb9-9567-454b-aef8-1c5eec6554e6", + "image_id": 204688, + "image_name": "12778.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1334.353, + 469.494, + 927.029, + 65.005 + ], + "priority": 10, + "parents": [ + 108089 + ], + "children": [ + 108081, + 108077, + 108084, + 108082, + 108072, + 108071, + 108080, + 108083, + 108085 + ], + "area": 626470.7273820001, + "iscrowd": 0, + "segmentation": [], + "text": "Visualizing Employment Trends" + }, + { + "id": 108072, + "strid": "65747648-71ad-436b-b38d-36dc61bf0414", + "image_id": 204688, + "image_name": "12778.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1263.806, + 550.451, + 1096.402, + 331.30600000000004 + ], + "priority": 11, + "parents": [ + 108065 + ], + "children": [], + "area": 695663.2765060001, + "iscrowd": 0, + "segmentation": [], + "text": "A new taxonomy and visualization tool from NIEHS examines\nthe employment trends in biomedical sciences by sector,\ntype, and job specifics. The study contains data from a total\nof 900 NIEHS postdoctoral fellows over the past 15 years. An\ninteractive platform for comparing trends is below, and the\ncode is freely available for others to use for customizing for\ntheir particular institution.?4" + }, + { + "id": 108077, + "strid": "61cd41b1-98fe-4c55-a959-67247622d4bc", + "image_id": 204688, + "image_name": "12778.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1292.263, + 900.556, + 1022.549, + 591.767 + ], + "priority": 12, + "parents": [ + 108065 + ], + "children": [], + "area": 1163755.198228, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 108085, + "strid": "bc25294e-700d-4935-8227-9c74185747e9", + "image_id": 204688, + "image_name": "12778.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1277.098, + 1608.51, + 14.663000000000011, + 162.73299999999995 + ], + "priority": 13, + "parents": [ + 108065 + ], + "children": [], + "area": 2054224.90398, + "iscrowd": 0, + "segmentation": [], + "text": "40}99g JuDWIAO| dU" + }, + { + "id": 108080, + "strid": "71a62d08-7508-455e-97d8-b8051b33f523", + "image_id": 204688, + "image_name": "12778.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1340.225, + 1583.787, + 321.202, + 207.08400000000006 + ], + "priority": 14, + "parents": [ + 108065 + ], + "children": [], + "area": 2122630.932075, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 108084, + "strid": "11a1a662-e73d-4451-b840-807a551995d2", + "image_id": 204688, + "image_name": "12778.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1277.385, + 1853.76, + 14.375999999999976, + 117.59400000000005 + ], + "priority": 15, + "parents": [ + 108065 + ], + "children": [], + "area": 2367965.2176, + "iscrowd": 0, + "segmentation": [], + "text": "dd Ay Add “QT BI" + }, + { + "id": 108081, + "strid": "9653108e-842f-4b64-abff-8cc4e07b012d", + "image_id": 204688, + "image_name": "12778.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1339.403, + 1808.733, + 426.97399999999993, + 206.8599999999999 + ], + "priority": 16, + "parents": [ + 108065 + ], + "children": [], + "area": 2422622.406399, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 108083, + "strid": "fe14701e-44a4-48b8-911b-dc6ad6a3d6d6", + "image_id": 204688, + "image_name": "12778.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1276.716, + 2075.643, + 15.214999999999918, + 121.72200000000021 + ], + "priority": 17, + "parents": [ + 108065 + ], + "children": [], + "area": 2650006.6283879997, + "iscrowd": 0, + "segmentation": [], + "text": "uonoUuNny Gor ‘do, S14" + }, + { + "id": 108082, + "strid": "0e85d22f-c672-4893-8bd5-7aedd6d68129", + "image_id": 204688, + "image_name": "12778.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1338.456, + 2036.421, + 446.856, + 207.33299999999986 + ], + "priority": 18, + "parents": [ + 108065 + ], + "children": [], + "area": 2725659.905976, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 108071, + "strid": "a2431e84-0cfc-42b8-b257-7dc9d4ffc977", + "image_id": 204688, + "image_name": "12778.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1813.155, + 1551.577, + 509.0980000000002, + 763.6470000000002 + ], + "priority": 19, + "parents": [ + 108065 + ], + "children": [], + "area": 2813249.595435, + "iscrowd": 0, + "segmentation": [], + "text": "Wayne State University of\nthe NIH BEST Consortium\nvisualizes career outcomes\nof biomedical doctoral\nalumni from the past 15\nyears using the Rescuing\nBiomedical Research (RBR)\nTaxonomy.®*” Outcomes\nare divided by employment\nsector, career type, and job\nfunction within three time\nwindows: 0-5 years (inner\ncircle); 6-10 years (middle\ncircle) and 11-15 years\n(outer circle) from receiving\ndoctoral degree." + }, + { + "id": 108066, + "strid": "24f60fa8-c718-4777-b959-74bca9d732ba", + "image_id": 204688, + "image_name": "12778.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2576.519, + 471.682, + 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A.'; Burbano Girdn J. 2; .Echeverry Galvis M. A. 3\nEcologist - Pontificia Universidad Javeriana - malejaberbeo@gmail.com\n2Director of the master Use and Conervacidn of Biodiversity - Pontificia Universidad Javeriana - ma.echeverryg@javeriana.edu.co\n3PhD student - Estudios Ambientales y Rurales; Pontificia Universidad Javeriana - jaimebg27@gmail.com" + }, + { + "id": 107777, + "strid": "4e54cbe5-6b05-4906-9f9c-2d8483876759", + "image_id": 204675, + "image_name": "12757.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1236.695, + 403.965, + 303.655, + 33.47800000000001 + ], + "priority": 3, + "parents": [ + 107809 + ], + "children": [ + 107807 + ], + "area": 499581.49567499995, + "iscrowd": 0, + "segmentation": [], + "text": "1. INTRODUCTION" + }, + { + "id": 107807, + "strid": "ea487c8c-48d6-4955-8665-24543e5de4b7", + "image_id": 204675, + "image_name": "12757.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 187.389, + 473.28, + 2390.419, + 587.738 + ], + "priority": 4, + "parents": [ + 107777 + ], + "children": [], + "area": 88687.46592, + "iscrowd": 0, + "segmentation": [], + "text": "Food demand has led to the expansion of agricultural territories and increased its productivity . This expansion is mean cause of the transformation of the neotropical landscape\nLaurance et al. 2014; Lambin et al. 2000; Wassenaar et al. 2007) ANd also generates the loss and fragmentation habitat. In this sence, the composition, estructure, funtion and the provision of ecosystem\nservices, are impacted in a negative way (Metzger et al. 2006).\n\nn this context, the efforts for the conservation have focused on the creation of several protected areas systems (Jenkins & Joppa 2009). Nevertheless, the success of this systems has been\ndiscussed due to these areas are not in many cases representative of the biodiversisty (williams et al. 2005; Cabeza & Moilanen 2001; Haight & Travis 2008), Not protect in high measure the threate-\nNed species (Hoffmann et al. 2010), ANd not guarantee the regional and local economic dynamics; whitout this dynimics the conservation efforts have a low probability of succes (Camwardine,\nKerrie A. Wilson, et al. 2008)...\n\nn this way, exist a debate between mximizing the economic yield of agricultural practices and the protection of biodiversity (rhalanetal.2011). Despite this, there are alternatives of\nandscape management that can complement these two approaches, one of these alternatives is “land sharing” (Fischer et al. 2008; Balmford et al. 2012; Phalan et al. 2011)\n\nThe most suitable way to optimize the two processes: economic and conservationist, is including the costs of conserving biodiversity in productive and agricultural areas (Naidoo et\nal. 2006);iN adition, it must be taken into account substitutes for biodiversity that allow prioritizing both agricultural activities and biodiversity, it means that the substitutes should use\nboth their natural habitat and the agricultural areas. The primates, are species frequently used in this type of exercises (Norconketal.2011), due to some of these species are umbrela\nSPECIES (Lambert 2011), SOME species of primates are involved in seed dispersal and have been observed in agricultural Greas as foraging places. (estrada et al. 2012).\n\nThis study aims to identify agricultural areas that may contribute to the conservation of neotropical primates through a cost-benefit approach. A spatially explicit multicriteria ap-\nproach is used to analyze the ecological requirements of primates, focusing on their habitat suitability, the distribution of the most important agricultural areas of the neotropical\nregion, and the opportunity costs associated with them." + }, + { + "id": 107778, + "strid": "3e20e0b9-ab04-4f51-809a-a2b191e735ab", + "image_id": 204675, + "image_name": "12757.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 640.428, + 1158.301, + 249.66099999999994, + 34.08699999999999 + ], + "priority": 5, + "parents": [ + 107809 + ], + "children": [ + 107805, + 107806 + ], + "area": 741808.3928279999, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 107805, + "strid": "d4d57bd4-0e9c-447b-b567-6b55e9fb5756", + "image_id": 204675, + "image_name": "12757.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 260.204, + 1245.233, + 429.239, + 198.6210000000001 + ], + "priority": 6, + "parents": [ + 107778 + ], + "children": [], + "area": 324014.607532, + "iscrowd": 0, + "segmentation": [], + "text": "GENERAL\n\nEstimate the potential of some\nagricultural uses as complemen-\ntary areas for the conservation of\nneotropical primates." + }, + { + "id": 107806, + "strid": "d15d7a1e-7a0b-46b2-bd2a-cf9757835a08", + "image_id": 204675, + "image_name": "12757.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 842.183, + 1244.63, + 457.01, + 262.615 + ], + "priority": 7, + "parents": [ + 107778 + ], + "children": [], + "area": 1048206.2272900001, + "iscrowd": 0, + "segmentation": [], + "text": "SPECIFIC\n\nIdentify areas that are ecologically\nsuitable for neotropical primates.\n\nDetermine the opportunity cost of\nthe agricultural use areas of the re-\ngion" + }, + { + "id": 107780, + "strid": "50e143ff-37f5-4c66-abfd-caa46d119e5a", + "image_id": 204675, + "image_name": "12757.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 605.707, + 1557.092, + 318.946, + 36.02800000000002 + ], + "priority": 8, + "parents": [ + 107809 + ], + "children": [ + 107799, + 107788, + 107793, + 107801, + 107795, + 107786, + 107796, + 107792, + 107800, + 107798, + 107789, + 107797, + 107787, + 107794, + 107791 + ], + "area": 943141.5240440001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 107799, + "strid": "2cecfa2b-2200-43cb-a91f-71ba09e7c20d", + "image_id": 204675, + "image_name": "12757.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 267.01, + 1692.384, + 194.26, + 57.94100000000003 + ], + "priority": 9, + "parents": [ + 107780 + ], + "children": [], + "area": 451883.45184, + "iscrowd": 0, + "segmentation": [], + "text": "NEOTROPICALES\nPRIMATES" + }, + { + "id": 107801, + "strid": "274cf165-1f1b-463e-ab81-6a572d8d4e1c", + "image_id": 204675, + "image_name": "12757.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 582.448, + 1638.396, + 785.668, + 162.88200000000006 + ], + "priority": 10, + "parents": [ + 107780 + ], + "children": [], + "area": 954280.473408, + "iscrowd": 0, + "segmentation": [], + "text": "133 sp were divided into 5 groups with the expert help. The\ndistribution of species was made through the intersection of\nthe habitat and expert polygon of each of the species from\nthe IUCN. This allowed to generate the proximity to prefe-\nrential hdbitat variable." + }, + { + "id": 107798, + "strid": "c124e135-b7ee-4394-8b2b-90b623190738", + "image_id": 204675, + "image_name": "12757.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 229.229, + 1892.145, + 264.42499999999995, + 62.202999999999975 + ], + "priority": 11, + "parents": [ + 107780 + ], + "children": [], + "area": 433734.50620500004, + "iscrowd": 0, + "segmentation": [], + "text": "NEOTROPICAL\nAGRICULTURAL AREAS" + }, + { + "id": 107800, + "strid": "fd4239f2-715f-4395-ab3c-7ba07d73ec7c", + "image_id": 204675, + "image_name": "12757.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 573.825, + 1831.939, + 787.5840000000001, + 145.63599999999997 + ], + "priority": 12, + "parents": [ + 107780 + ], + "children": [], + "area": 1051212.3966750002, + "iscrowd": 0, + "segmentation": [], + "text": "The variables of yield, cost of production and profitability of\neach of the crops were downloaded to the smallest scale of\nthe last five years of each country, this was done through the\nofficial portals of each country and FAO in some cases." + }, + { + "id": 107797, + "strid": "4a527059-471a-4708-89be-ea6dd9076f70", + "image_id": 204675, + "image_name": "12757.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 523.56, + 2051.627, + 483.922, + 37.771999999999935 + ], + "priority": 13, + "parents": [ + 107780 + ], + "children": [], + "area": 1074149.83212, + "iscrowd": 0, + "segmentation": [], + "text": "3.1 PRELIMINARY PRODUCTS" + }, + { + "id": 107791, + "strid": "ea64cfc1-2067-4846-9acd-f1f878a2ea2d", + "image_id": 204675, + "image_name": "12757.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 194.082, + 2183.024, + 332.94999999999993, + 28.268999999999778 + ], + "priority": 14, + "parents": [ + 107780 + ], + "children": [], + "area": 423685.663968, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 107796, + "strid": "c2d22357-1ce3-4b39-9fe1-559fe3ec8a17", + "image_id": 204675, + "image_name": "12757.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 622.257, + 2142.712, + 677.58, + 109.77500000000009 + ], + "priority": 15, + "parents": [ + 107780 + ], + "children": [], + "area": 1333317.5409839998, + "iscrowd": 0, + "segmentation": [], + "text": "HSI = (0.2 * NPP) + (0.3 * C) + (0.2 * TD) + (0.3 * PH)\n\nHSI: Habitat suitability index DA: Tree Density\nNee: Net Primary Productivity PH: Proximity to habitat\n: Cover" + }, + { + "id": 107792, + "strid": "22cd19ca-f7fb-4fa7-8eef-b75863be2482", + "image_id": 204675, + "image_name": "12757.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 232.373, + 2453.003, + 266.24, + 61.32499999999982 + ], + "priority": 16, + "parents": [ + 107780 + ], + "children": [], + "area": 570011.6661190001, + "iscrowd": 0, + "segmentation": [], + "text": "OPPROTUNITY COST\nMAP" + }, + { + "id": 107795, + "strid": "535caa75-5f81-4cfc-8d2f-23b855b706c0", + "image_id": 204675, + "image_name": "12757.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 598.909, + 2286.801, + 281.722, + 358.7249999999999 + ], + "priority": 17, + "parents": [ + 107780 + ], + "children": [], + "area": 1369585.7001089999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 107793, + "strid": "fc802221-ce61-43da-8739-ea0c343ce3b9", + "image_id": 204675, + "image_name": "12757.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 948.295, + 2325.546, + 271.369, + 108.97499999999991 + ], + "priority": 18, + "parents": [ + 107780 + ], + "children": [], + "area": 2205303.64407, + "iscrowd": 0, + "segmentation": [], + "text": "Pr= PC/Y\nPr: Profitability\nPC: Production cost\nY: Yield" + }, + { + "id": 107794, + "strid": "5cec78d5-da72-4fab-9fe5-9466524ef72a", + "image_id": 204675, + "image_name": "12757.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 950.966, + 2481.529, + 300.74900000000014, + 108.4409999999998 + ], + "priority": 19, + "parents": [ + 107780 + ], + "children": [], + "area": 2359849.707014, + "iscrowd": 0, + "segmentation": [], + "text": "OC = (Pr + Y+ PC)/3\nportunity cost\n+ Br Proffapil y" + }, + { + "id": 107788, + "strid": "cfea3d10-4f3a-47a4-aafc-38fa01763854", + "image_id": 204675, + "image_name": "12757.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 594.832, + 2687.603, + 340.27200000000005, + 33.16199999999981 + ], + "priority": 20, + "parents": [ + 107780 + ], + "children": [], + "area": 1598672.267696, + "iscrowd": 0, + "segmentation": [], + "text": "RODUCT" + }, + { + "id": 107786, + "strid": "44b72627-1d6b-441b-95de-d24718581844", + "image_id": 204675, + "image_name": "12757.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 193.282, + 2815.925, + 340.27199999999993, + 158.6010000000001 + ], + "priority": 21, + "parents": [ + 107780 + ], + "children": [], + "area": 544267.6158500001, + "iscrowd": 0, + "segmentation": [], + "text": "POTENCIAL AGRICULTURAL\n\nAREAS FOR COMPLEMEN-\n\nTING THE CONSERVATION\n\nOF NEOTROPICAL PRIMA-\nTES MAP" + }, + { + "id": 107787, + "strid": "3d37afe8-e9e4-4bcb-b3bf-92b6e2e0ccd7", + "image_id": 204675, + "image_name": "12757.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 609.25, + 2818.088, + 326.57400000000007, + 141.29899999999998 + ], + "priority": 22, + "parents": [ + 107780 + ], + "children": [], + "area": 1716920.114, + "iscrowd": 0, + "segmentation": [], + "text": "P=SHI/OC\n\nP: Potential\nHSI: Habitat suitability index\nOC: Opportunity cost" + }, + { + "id": 107789, + "strid": "c97e0eaa-c20d-461d-9f3d-325461fe868d", + "image_id": 204675, + "image_name": "12757.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1079.287, + 2752.485, + 285.48199999999997, + 274.6680000000001 + ], + "priority": 23, + "parents": [ + 107780 + ], + "children": [], + "area": 2970721.2781950003, + "iscrowd": 0, + 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"category_id": 2, + "category_name": "Figure", + "bbox": [ + 1464.819, + 1658.139, + 1137.3269999999998, + 542.3639999999998 + ], + "priority": 26, + "parents": [ + 107779 + ], + "children": [], + "area": 2428873.5118409996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 107802, + "strid": "3c15e2cb-7a74-4497-8e09-a9f5fd954904", + "image_id": 204675, + "image_name": "12757.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1546.377, + 2237.209, + 932.951, + 37.92000000000007 + ], + "priority": 27, + "parents": [ + 107779 + ], + "children": [], + "area": 3459568.5417929995, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 107785, + "strid": "62cfa19d-cf4f-4ec3-ba35-b92a2f4024d5", + "image_id": 204675, + "image_name": "12757.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1593.008, + 2320.868, + 857.2809999999997, + 26.909999999999854 + ], + "priority": 28, + "parents": [ + 107779 + ], + "children": [], + "area": 3697161.290944, + "iscrowd": 0, + "segmentation": [], + "text": "Potential of agricultural zones vs. protected areas, a) Mexico, b) Colombia" + }, + { + "id": 107790, + "strid": "218811ac-4597-41f0-836b-24f27c8f9ae1", + "image_id": 204675, + "image_name": "12757.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1462.527, + 2354.632, + 1134.2960000000003, + 557.8510000000001 + ], + "priority": 29, + "parents": [ + 107779 + ], + "children": [], + "area": 3443712.875064, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 107782, + "strid": "e2eaa715-e22c-4398-af5e-4cde974881df", + "image_id": 204675, + "image_name": "12757.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1861.901, + 2956.359, + 301.4359999999999, + 34.78099999999995 + ], + "priority": 30, + "parents": [ + 107809 + ], + "children": [ + 107808, + 107784 + ], + "area": 5504447.778459, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 107784, + "strid": "7ba942b7-e423-487f-8f62-bf1f7b569ac1", + "image_id": 204675, + "image_name": "12757.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1473.116, + 2985.511, + 1121.451, + 596.6749999999997 + ], + "priority": 31, + "parents": [ + 107782 + ], + "children": [], + "area": 4398004.022276, + "iscrowd": 0, + "segmentation": [], + "text": "The Amazon, Andes and part of the Pacific are suitable for the distribution of spe-\ncies of primates - mature forests. However, there are also relics of forests in the\nnorthern part of Honduras and Nicaragua and part of the Atlantic Forest.\n\nSome crops such as coffee may be suitable for primates due to plant structure.\nHowever, other crops such as soybeans in the southern part of the study area\ngenerate abrupt deforestation processes that do not contribute in any way to\nthe conservation of primates.\n\nIncluding variables such as the potential distribution of the species can better evi-\ndence the results of the suitability index and at the same time be the proxy of\nvariables such as the seasonality on which the primate species depend.\n\nThe Mexican zone has great opportunities to be areas that complement existing\nconservation initiatives because they are very cost effective areas that have\nbeen identified several times by several authors.\n\nSome areas with a low potential value in this study have local initiatives that are al-\nready contributing to the conservation of primates" + }, + { + "id": 107808, + "strid": "cd344065-ebb1-47a7-8aa5-68c8764f6331", + "image_id": 204675, + "image_name": "12757.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1473.911, + 3593.867, + 1117.772, + 62.440000000000055 + ], + "priority": 32, + "parents": [ + 107782 + ], + "children": [], + "area": 5297040.103837, + "iscrowd": 0, + "segmentation": [], + "text": "Contemplating agricultural areas within conservation should be as important as\nidentifying priority natural areas for conservation." + }, + { + "id": 107781, + "strid": "a2a02726-bbe2-43e3-978d-384b4f4915b2", + "image_id": 204675, + "image_name": "12757.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 662.611, + 3067.476, + 209.69899999999996, + 35.42599999999993 + ], + "priority": 33, + "parents": [ + 107809 + ], + "children": [ + 107783 + ], + "area": 2032543.339836, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 107783, + "strid": "2554a01f-32f5-4993-afd2-d2b4592b1aee", + "image_id": 204675, + "image_name": "12757.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 167.581, + 3120.434, + 1171.881, + 646.1889999999999 + ], + "priority": 34, + "parents": [ + 107781 + ], + "children": [], + "area": 522925.450154, + "iscrowd": 0, + "segmentation": [], + "text": "Balmford: A...Gaston, KJ)... Rodrigues, ASL. & James, A. (2016) Society for Conservation Biology Integrating Costs of Conservation into International Priority\nSetting Published by : Wiley for Society for Conservation Biology Linked references are available on JSTOR for this article : Issues in International Con-\nservati. , 14, 597-605.\n\nCarwardine, J., Wilson, K.A., Ceballos, G., Ehrlich, P.R., Naidoo, R., Iwamura, T., Hajkowicz, S. a & Possingham, H.P. (2008a) Cost-effective priorities for\nglobal mammal conservation. Proceedings of the National Academy of Sciences of the United States of America, 105, 11446-11450.\n\n \n\nEstrada, A. (2013a) Socioeconomic Contexts of Primate Conservation: Population, Poverty, Global Economic Demands, and Sustainable Land Use. American\nJournal of Primatology, 75, 30-45.\n\nEstrada, A., Raboy, B.E. & Oliveira, L.C. (2012a) Agroecosystems and Primate Conservation in The Tropics: A Review. American Journal of Primatology, 74, 696-\n711.\n\nEstrada, A., Saenz, J., Harvey, C., Naranjo, E., Mufioz, D., Rosales-meda, M., Rica, C. & Agricultura, D. De. (2005) Primates in agroecosystems : conservation\nvalue of some agricultural practices in Mesoamerican landscapes. New Perspectives in the Study of Mesoamerican Primates: Distribution, Ecology, Behavior, and\nConservation, 437-470.\n\nFischer, J., Brosi, B., Daily, G.C., Ehrlich, P.R., Goldman, R., Goldstein, J., Lindenmayer, D.B., Manning, A.D., Mooney, H.A., Pejchar, L., Ranganathan, J. &\nTallis, H. (2008) Should agricultural policies encourage land sparing or wildlife-friendly farming? Frontiers in Ecology and the Environment, 6, 380-385.\n\nHaight, R.G. & Travis, L.E. (2008) Reserve design to maximize species persistence. Environmental Modeling and Assessment, 13, 243-253\nJenkins, C.N. & Joppa, L. (2009) Expansion of the global terrestrial protected area system. Biological Conservation, 142, 2166-2174.\n\nLambin, E.F., Rounsevell, M.D.A. & Geist, H.J. (2000) Are agricultural land-use models able to predict changes in land-use intensity? Agriculture, Ecosystems\nand Environment, 82, 321-331.\n\nLaurance, W.F., Sayer, J. & Cassman, K.G. (2014) Agricultural expansion and its impacts on tropical nature. Trends in Ecology and Evolution, 29, 107-116\n\nMetzger, M.J., Rounsevell, M.D. a., Acosta-Michlik, L., Leemans, R. & Schréter, D. (2006) The vulnerability of ecosystem services to land use change. Agricul-\nture, Ecosystems & Environment, 114, 69-85.\n\nNaidoo, R. & Ricketts, T.H. (2006) Mapping the economic costs and benefits of conservation. PLoS biology, 4, e360.\n\nNaidoo, R., Balmford, A., Ferraro, P.J., Polasky, S., Ricketts, T.H. & Rouget, M. (2006) Integrating economic costs into conservation planning. Trends in Ecology\nand Evolution, 21, 681-687.\n\nPhalan, B., Onial, M., Balmford, A. & Green, R.E. (2011) Reconciling Food Production and Biodiversity Conservation: Land Sharing and Land Sparing Com-\npared. Science, 333, 1289-1291.\n\nWassenaar, T., Gerber, P., Verburg, P.H., Rosales, M., Ibrahim, M. & Steinfeld, H. (2007) Projecting land use changes in the Neotropics: The geography of\npasture expansion into forest. Global Environmental Change, 17, 86-104.\n\nWilliams, J.C., ReVelle, C.S. & Levin, S.A. (2005) Spatial attributes and reserve design models: A review. Environmental Modeling and Assessment, 10, 163-181." + }, + { + "id": 71914, + "strid": "429cc46d-81ea-4973-9d62-0ac4fe2b76e8", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 356.36, + 265.79, + 411.88, + 196.13 + ], + "priority": -1, + "parents": [], + "children": [ + 71888, + 71887, + 71915, + 71880, + 71885, + 71884, + 71878, + 71882, + 71889, + 71881, + 71879, + 71886, + 71883 + ], + "area": 94716.92440000002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 71878, + "strid": "e6790199-ca54-412f-bf5b-4801ae6b8e5a", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 353.808, + 116.137, + 3650.24, + 103.07900000000001 + ], + "priority": 1, + "parents": [ + 71914 + ], + "children": [], + "area": 41090.199695999996, + "iscrowd": 0, + "segmentation": [], + "text": "Making categorical decisions inder conditions of perceptual and categorical noise" + }, + { + "id": 71879, + "strid": "3854acba-9212-451d-8941-48c6be4523be", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 848.385, + 235.121, + 2678.058, + 192.636 + ], + "priority": 2, + "parents": [ + 71914 + ], + "children": [], + "area": 199473.12958500002, + "iscrowd": 0, + "segmentation": [], + "text": "Swetha Shankar’’, Andrew S. Kayser”\n'Ernest Gallo Clinic & ReSearch Center, Emeryville, CA, “UC San Francisco, San Francisco, CA, USA" + }, + { + "id": 71880, + "strid": "9344eeca-ba9c-4837-96e9-6944239a1864", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 179.709, + 648.703, + 399.66400000000004, + 55.65599999999995 + ], + "priority": 3, + "parents": [ + 71914 + ], + "children": [ + 71890 + ], + "area": 116577.767427, + "iscrowd": 0, + "segmentation": [], + "text": "1. Introduction" + }, + { + "id": 71890, + "strid": "52d04c87-0a48-4b28-8300-c7117168b12a", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 201.388, + 732.585, + 1887.096, + 597.6309999999999 + ], + "priority": 4, + "parents": [ + 71880 + ], + "children": [], + "area": 147533.82798, + "iscrowd": 0, + "segmentation": [], + "text": "Categorization eases perceptual and memory butden by mapping individual stimuli into groups that\ngeneralize over stimulus features. However, categorization can be affected by ambiguity present either in the\nperceptual domain (degraded stimulus) or categorical domain (proximity to category boundary). Perceptual\ndecision-making (PDM), which shares, some’ features with categorization, is believed to occur in “a\nfrontoparietal network constituted by the itfaparietal sulcus and inferior frontal sulcus, amongst othet ateas\n(1,2). In macaque categorization studies, posterior parietal cortex (PPC) and lateral prefrontal cortex (PFC)\nneurons have been shown to reflect-stimulus category in a fashion that is modulated byedistamce from\ncategory boundary (3,4). These studies have, however, primarily modulated ambiguity in oflyNone of the\ndomains. Here, we combine*both kinds of ambiguity to identify the behavioral manifestations and neural\ncorrelates of categorizatfoneunder different sources of noise. To this end we utilize, the random-dot\nkinetogram — a stimulus that has been used in both PDM and categorization studies)and lends itself well to\nmanipulations of both perceptual and categorical ambiguity." + }, + { + "id": 71881, + "strid": "46a2b902-22b0-4b74-9dee-a6a64e2e0495", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 183.728, + 1485.763, + 1873.0, + 70.70299999999997 + ], + "priority": 5, + "parents": [ + 71914 + ], + "children": [], + "area": 272976.264464, + "iscrowd": 0, + "segmentation": [], + "text": "2. Background — correlates of PDM and categorization in humans and" + }, + { + "id": 71915, + "strid": "5eeae249-6e9b-42e7-8ba4-b6a18cd027d0", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 183.755, + 1556.438, + 562.74, + 65.42499999999995 + ], + "priority": 6, + "parents": [ + 71914 + ], + "children": [ + 71901, + 71892, + 71900 + ], + "area": 286003.26469000004, + "iscrowd": 0, + "segmentation": [], + "text": "non-human primates" + }, + { + "id": 71901, + "strid": "fc8d1175-1b85-4ccc-8282-7de3918c28ce", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 196.444, + 1637.139, + 1217.963, + 428.874 + ], + "priority": 7, + "parents": [ + 71915 + ], + "children": [], + "area": 321606.13371599995, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 71900, + "strid": "70abe18e-0a22-4f1e-b269-e1ab15e5baaf", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1550.695, + 1609.276, + 539.597, + 455.49199999999996 + ], + "priority": 8, + "parents": [ + 71915 + ], + "children": [], + "area": 2495496.24682, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 71892, + "strid": "a5866e26-7aa5-4b06-b689-f977abfa0a5b", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 183.917, + 2103.589, + 1931.0060000000003, + 392.58100000000013 + ], + "priority": 9, + "parents": [ + 71915 + ], + "children": [], + "area": 386885.778113, + "iscrowd": 0, + "segmentation": [], + "text": "Historically, understanding the function of perceptual decision making began with mathematical models of human behavior‘in which evidence\nfor each outcome accumulates over time imyproportion to the strength of the stimulus. Shadlen and others subsequently discovered that such\nmodels accurately describe firing rates in weurons within the lateral intraparietal area (LIP) in response to dot motion stimulie(above left; Ref.5).\nSpecifically, the rate of evidence accummtilation varies with dot-motion coherence, while the threshold required for a tesPonse remains relatively\nconstant. Consistent with these findings, studies in humans have identified a number of brain regions involved i perceptual decisions more\ngenerally (Ref.7), and in respor's@tordot motion stimuli in particular (above middle; Ref.1). However, sourgés of ambiguity other than varying\nperceptual salience can be pfésent. Freedman and Miller (Ref.6) have shown, for example, that neurons in macaque PFC also modulate their\nfiring based on the distariceef/ an exemplar stimulus from category boundary (dog vs. cat) in a task that @mployed morphed images of cats and\ndogs (above right). Ta the current study, we varied both motion coherence and distance from the ¢ategery/ boundary in order to determine\nwhether perceptual and\\eéategorical decisions activate similar networks in humans." + }, + { + "id": 71884, + "strid": "08e50f3c-158a-41b4-ab65-0cc8b6f22a2b", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 182.05, + 2654.8, + 1580.023, + 70.55000000000018 + ], + "priority": 10, + "parents": [ + 71914 + ], + "children": [ + 71903, + 71893, + 71899, + 71902 + ], + "area": 483306.3400000001, + "iscrowd": 0, + "segmentation": [], + "text": "3..Categorization task with perceptual and,categorical noise" + }, + { + "id": 71899, + "strid": "b854205a-50be-471e-a329-8babd0fe270b", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 232.397, + 2738.606, + 988.3780000000002, + 641.489 + ], + "priority": 11, + "parents": [ + 71884 + ], + "children": [], + "area": 636443.818582, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 71902, + "strid": "c3693301-f2d8-4b00-8b20-947363683447", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1406.527, + 2765.237, + 675.5830000000001, + 594.8820000000001 + ], + "priority": 12, + "parents": [ + 71884 + ], + "children": [], + "area": 3889380.5018990003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 71903, + "strid": "ccff8bbd-a7c9-4eb9-8e61-740d480ec486", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 194.511, + 3439.889, + 1957.2530000000002, + 628.8820000000001 + ], + "priority": 13, + "parents": [ + 71884 + ], + "children": [], + "area": 669096.249279, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 71893, + "strid": "5e3a72d6-dce6-4169-8433-2f74bfa31c52", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 172.49, + 4089.641, + 1924.544, + 122.93700000000035 + ], + "priority": 14, + "parents": [ + 71884 + ], + "children": [], + "area": 705422.1760900001, + "iscrowd": 0, + "segmentation": [], + "text": "Accuracy and response times (RT) are presented from 3,subjetts selected to show the range of behavior. As stimulus or category salience\nincreased, accuracy improved and RT decreased. We also Observed a significant interaction between ambiguity in the perceptual andatégorical\ndomains (Accuracy, p<<10°; RT, p<<10°)." + }, + { + "id": 71885, + "strid": "e595c219-5e3b-4be1-8b56-b6417dbb4fa2", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 177.809, + 4373.631, + 1873.8170000000002, + 142.0029999999997 + ], + "priority": 15, + "parents": [ + 71914 + ], + "children": [ + 71894, + 71904, + 71896 + ], + "area": 777670.9544790001, + "iscrowd": 0, + "segmentation": [], + "text": "4. Main effect oftask reveals frontoparietal and temporo-occipital lobe\nactivation undérlying categorization, similar to PDM" + }, + { + "id": 71896, + "strid": "c9a429f0-1dc2-4723-8e16-7be6c0861e8d", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 186.443, + 4583.417, + 430.428, + 339.34500000000025 + ], + "priority": 16, + "parents": [ + 71885 + ], + "children": [], + "area": 854546.0157310001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 71904, + "strid": "cb4820a6-58ea-44d8-9e0e-ba7eea2eec18", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 783.385, + 4527.802, + 1350.6589999999999, + 510.66600000000017 + ], + "priority": 17, + "parents": [ + 71885 + ], + "children": [], + "area": 3547012.1697699996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 71894, + "strid": "05fee51a-fe88-45ac-a2cb-fa584615694e", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 175.013, + 5053.441, + 1882.1690000000003, + 47.87299999999959 + ], + "priority": 18, + "parents": [ + 71885 + ], + "children": [], + "area": 884417.8697329999, + "iscrowd": 0, + "segmentation": [], + "text": "All functional maps were thresholded at p<0.005 uncorrected afd cluster size corrected to achieve a corrected significance value of p<0.05." + }, + { + "id": 71886, + "strid": "738f9066-e61b-4800-a2dc-579c7145d4e0", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 182.664, + 5245.617, + 1899.9869999999999, + 139.51000000000022 + ], + "priority": 19, + "parents": [ + 71914 + ], + "children": [ + 71906, + 71905 + ], + "area": 958185.3836879999, + "iscrowd": 0, + "segmentation": [], + "text": "5. Parametric representation of perceptual and categorical ambiguity in\nthe categorization network" + }, + { + "id": 71905, + "strid": "cc88a79d-5163-4a78-bea1-def94530b6d6", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 176.779, + 5415.672, + 1960.161, + 608.6490000000003 + ], + "priority": 20, + "parents": [ + 71886 + ], + "children": [], + "area": 957377.080488, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 71906, + "strid": "5f64bb59-2458-4945-a68a-0a00bf76e037", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 183.516, + 6059.87, + 1936.895, + 644.5780000000004 + ], + "priority": 21, + "parents": [ + 71886 + ], + "children": [], + "area": 1112083.10292, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 71883, + "strid": "e086987e-76e7-477f-bdf2-2680dfd32271", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2276.293, + 656.859, + 1887.4870000000005, + 144.86 + ], + "priority": 22, + "parents": [ + 71914 + ], + "children": [ + 71907, + 71891 + ], + "area": 1495203.5436870002, + "iscrowd": 0, + "segmentation": [], + "text": "6. Do frontal cortical areas not represeht.perceptual ambiguity? Map of\ninteraction effects says otherwise" + }, + { + "id": 71907, + "strid": "2f8692f8-7933-4808-9b5c-b227dd470aa9", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2431.334, + 832.867, + 1781.4719999999998, + 500.568 + ], + "priority": 23, + "parents": [ + 71883 + ], + "children": [], + "area": 2024977.8545779998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 71891, + "strid": "6379e139-3cfa-48cb-8028-ba80bda5162a", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2273.837, + 1357.483, + 1934.2450000000003, + 125.27800000000002 + ], + "priority": 24, + "parents": [ + 71883 + ], + "children": [], + "area": 3086695.0722709997, + "iscrowd": 0, + "segmentation": [], + "text": "A 3-factor mixed-desiga ANOVA was performed with motion coherence and distance from category boundary as fixed factors and subject as\nrandom factor. This reyealed a strong interaction effect of motion coherence and distance from categofysboundary in the PDM/categorization\nnetwork. Regions ‘ef interest (ROIs) were created from the ANOVA map, thresholded at p<0.005.uncorrected and used in subsequent analyses." + }, + { + "id": 71882, + "strid": "8955154b-01a5-48aa-a539-719396193bd4", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2272.615, + 1637.402, + 1848.9499999999998, + 202.60500000000002 + ], + "priority": 25, + "parents": [ + 71914 + ], + "children": [ + 71908, + 71909 + ], + "area": 3721184.34623, + "iscrowd": 0, + "segmentation": [], + "text": "7¢ Category-coherence interactions: Parametric effects in frontal brain\nareas become increasingly negative as stimulus or category salience\nincreases" + }, + { + "id": 71908, + "strid": "f9bd3b7e-4d5d-46de-aa76-1eb809e88be2", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2288.946, + 1866.645, + 1551.246, + 449.61299999999983 + ], + "priority": 26, + "parents": [ + 71882 + ], + "children": [], + "area": 4272649.60617, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 71909, + "strid": "1dded374-d62d-418e-8c47-f0eadb7cf1a0", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2283.732, + 2349.361, + 1943.5020000000004, + 414.77199999999993 + ], + "priority": 27, + "parents": [ + 71882 + ], + "children": [], + "area": 5365310.895252, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 71889, + "strid": "73fbf69d-1194-48fd-a2a1-382e2141a501", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2272.642, + 2899.969, + 1752.5969999999998, + 146.69999999999982 + ], + "priority": 28, + "parents": [ + 71914 + ], + "children": [ + 71910, + 71912, + 71895, + 71913, + 71911 + ], + "area": 6590591.348098, + "iscrowd": 0, + "segmentation": [], + "text": "8. BOLD timecourses in the frontoparietal network show a similar\nmodulation of parametric effectwith stimulus salience" + }, + { + "id": 71910, + "strid": "441c5efd-c27b-43e0-a81e-19be1cb85067", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2287.081, + 3051.997, + 1906.6350000000002, + 548.5120000000002 + ], + "priority": 29, + "parents": [ + 71889 + ], + "children": [], + "area": 6980164.350757, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 71911, + "strid": "b9d3c003-157d-4ec6-978f-f95f97496ab4", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2291.079, + 3618.168, + 1899.3710000000005, + 542.9699999999998 + ], + "priority": 30, + "parents": [ + 71889 + ], + "children": [], + "area": 8289508.723272001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 71912, + "strid": "316be939-d423-4dd2-965b-d0939f64ce09", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2289.03, + 4175.481, + 1901.4200000000005, + 547.0680000000002 + ], + "priority": 31, + "parents": [ + 71889 + ], + "children": [], + "area": 9557801.273430001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 71913, + "strid": "1c2116af-957a-4977-8789-bd3fccfa6df9", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2284.353, + 4750.959, + 1908.3739999999998, + 610.2560000000003 + ], + "priority": 32, + "parents": [ + 71889 + ], + "children": [], + "area": 10852867.444527, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 71895, + "strid": "2d7a3e04-2154-40bf-903e-a6f2c64d7bfb", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2273.419, + 5379.247, + 1923.638, + 77.03499999999985 + ], + "priority": 33, + "parents": [ + 71889 + ], + "children": [], + "area": 12229282.335493, + "iscrowd": 0, + "segmentation": [], + "text": "Timecourses presented above are the averages obtained from the 8 voxels within each specified ROI that had the mostsignifieant “statistic for\nthe main effect of task. The ROIs wereycteated using the ANOVA map." + }, + { + "id": 71887, + "strid": "4261e1a1-d1d5-4747-ad7e-334992d4a22d", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2269.912, + 5598.167, + 390.1329999999998, + 52.9350000000004 + ], + "priority": 34, + "parents": [ + 71914 + ], + "children": [ + 71897 + ], + "area": 12707346.451304, + "iscrowd": 0, + "segmentation": [], + "text": "9. Conclusions" + }, + { + "id": 71897, + "strid": "de72df04-d78b-483a-8b5b-c93ff5d92210", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2289.293, + 5670.694, + 1888.373, + 391.6109999999999 + ], + "priority": 35, + "parents": [ + 71887 + ], + "children": [], + "area": 12981880.079342002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 71888, + "strid": "e49ea86f-57e8-42ee-8d79-1ebcff30801a", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2268.769, + 6218.34, + 380.24800000000005, + 47.21699999999964 + ], + "priority": 36, + "parents": [ + 71914 + ], + "children": [ + 71898 + ], + "area": 14107977.023459999, + "iscrowd": 0, + "segmentation": [], + "text": "10. References" + }, + { + "id": 71898, + "strid": "d5c7d094-7a52-43c7-9740-1d6b1286ff59", + "image_id": 203304, + "image_name": "120019.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2289.027, + 6284.408, + 1952.9449999999997, + 430.0100000000002 + ], + "priority": 37, + "parents": [ + 71888 + ], + "children": [], + "area": 14385179.591016002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 176637, + "strid": "27ed1b0f-f73d-48a2-8d28-f8dac704e7b1", + "image_id": 207393, + "image_name": "8009.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 210.37, + 116.52, + 114.07999999999998, + 130.37 + ], + "priority": -1, + "parents": [], + "children": [ + 176635, + 176613, + 176620, + 176612, + 176628, + 176634, + 176622, + 176625, + 176630, + 176629, + 176611, + 176619, + 176617, + 176621, + 176624, + 176633, + 176636, + 176627, + 176616, + 176631, + 176626, + 176623, + 176614, + 176632 + ], + "area": 24512.3124, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 176611, + "strid": "77ce8653-d224-4171-b37c-ec5b7cde5bcc", + "image_id": 207393, + "image_name": "8009.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 524.727, + 62.191, + 1433.087, + 74.695 + ], + "priority": 1, + "parents": [ + 176637 + ], + "children": [], + "area": 32633.296857, + "iscrowd": 0, + "segmentation": [], + "text": "Adoptive TIL in HPV-negative Oral SCCa" + }, + { + "id": 176612, + "strid": "c536927d-8977-482d-9624-6bb0194290db", + "image_id": 207393, + "image_name": "8009.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 526.496, + 159.289, + 2791.252, + 174.46699999999998 + ], + "priority": 2, + "parents": [ + 176637 + ], + "children": [], + "area": 83865.021344, + "iscrowd": 0, + "segmentation": [], + "text": "Rom Leidner'?, R. Bryan Bell’#, Marka Crittenden’, Roxanne Payne?, Krista Neslon?, Jennifer Moore?, Christopher Paustian’, Sachin Puri’, Allen Cheng?, Ashish Patel?, Tuan Bui?, Yedeh\nYing?, Traci L. Hilton*, Carlo B. Bifulco’, Hong-Ming Hu’, Tarsem Moudgil', Zipei Feng'?, Yoshinobu Koguchi', Keith Bahjat’, Brendan Curti', Walter Urba’, Bernard Fox’\n\n1Robert W. Franz Cancer Research Center, Earle A. Chiles Research Institute, Providence Cancer Center and 2Oral, Head and Neck Cancer Program and Clinic, Providence Cancer Center;\n3Molecular Microbiology and Immunology, OHSU, *UbiVac, Portland, OR 97213, USA. EE EERE TE WEXEEEESESESES" + }, + { + "id": 176613, + "strid": "fa3031ac-a3ca-4e40-b681-e457ee4bff48", + "image_id": 207393, + "image_name": "8009.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 66.669, + 378.596, + 252.639, + 37.896000000000015 + ], + "priority": 3, + "parents": [ + 176637 + ], + "children": [ + 176615 + ], + "area": 25240.616724, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 176615, + "strid": "17807f63-f2b8-46d0-a8cf-0dffd1c5fa0b", + "image_id": 207393, + "image_name": "8009.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 65.542, + 427.765, + 1077.617, + 1152.69 + ], + "priority": 4, + "parents": [ + 176613 + ], + "children": [], + "area": 28036.57363, + "iscrowd": 0, + "segmentation": [], + "text": "A 22 year old male was diagnosed with clinical T2 squamous cell\ncarcinoma of the lateral oral tongue. He underwent partial glossectomy\nwith elective neck dissection of ipsilateral cervical nodes levels I-IV.\nPathology showed a 2.1cm primary tumor with clear margins to 5mm,\n1.6cm depth of invasion, one of 23 lymph nodes with a 3.5mm focus of\ninvolvement at level II, sans extra-capsular extension (pT2 pN1 MO).\nThrough an institutional research tissue protocol, a primary cell line was\nsuccessfully established. TIL were simultaneously cultured and\ndemonstrated tumor specific IFNy production. He completed a course of\nadjuvant IMRT to 60Gy in the ipsilateral neck and 54Gy in the\ncontralateral neck within 12 weeks of surgery, without complications.\nThree months following completion of radiation, bilateral neck nodal\nrecurrence was noted on scans and confirmed by biopsy (month 6 of\ndisease course, overall). He was treated first line chemotherapy for\nrecurrent disease during months 7 to 10, progressing locally in the neck\nthrough two multi-drug regimens (cisplatin/cetuximab/5FU, carboplatin/\ndocetaxel). He then enrolled on a phase lb trial of combination anti-\nPD-1 / anti-KIR during months 11 to 14 (BMS CA223-001, Nivolumab /\nLirilumab), again progressing locally in the neck. At month 15, an\nindividual patient compassionate treatment protocol was approved (FDA\nIND #16279, PH&S IRB #14-323B), using reduced-intensity Cy/Flu\npreparative lymphodepletion followed by adoptive transfer of expanded\nautologous TIL in conjunction with DC-targeted microvessicle DPV-001\nintradermal vaccine (DRibbles) and imiquimod adjuvant, with high-dose\nIL-2 support. Peripheral immune monitoring was performed using whole\nblood time-course sampling. Multi-spectral immunofluorescence with\ndigital image quantitative immunophenotyping of FFPE longitudinal\nbiopsy specimens was performed on the PerkinElmer Vectra® platform.\nPlease see related posters #40, 92 and 268." + }, + { + "id": 176619, + "strid": "5e678052-eafa-4bec-b7dc-819d38f484c6", + "image_id": 207393, + "image_name": "8009.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 102.419, + 1638.309, + 1008.3470000000001, + 143.3040000000001 + ], + "priority": 5, + "parents": [ + 176637 + ], + "children": [], + "area": 167793.969471, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 176626, + "strid": "c28aaba8-29ea-40b6-bb57-83bcee4d3655", + "image_id": 207393, + "image_name": "8009.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 112.256, + 1816.819, + 764.395, + 215.04999999999995 + ], + "priority": 6, + "parents": [ + 176637 + ], + "children": [], + "area": 203948.833664, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 176635, 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"iscrowd": 0, + "segmentation": [], + "text": "STANDARDIZED\nPHENOTYPING FOR\nEACRI CLINICAL\nTRIALS" + }, + { + "id": 176616, + "strid": "3648f2a1-814c-4a30-b2f0-3b4f86a689b3", + "image_id": 207393, + "image_name": "8009.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1204.0, + 3529.311, + 154.57600000000002, + 323.75099999999975 + ], + "priority": 23, + "parents": [ + 176637 + ], + "children": [], + "area": 4249290.444, + "iscrowd": 0, + "segmentation": [], + "text": "RESERVE BEST\nFLUOROCHROMES FOR\nDIMMEST ANTIGENS\n\nMINIMIZE SPECTRAL\nOVERLAP INTO RESERVED\nCHANNELS.\n\nUSE ONLY SINGLE DYES\n(NO TANDEMS) FOR\nRESERVED CHANNELS\n\nUSE MINIMAL CORE\nCOCKTAIL TO DEFINE\nPOPULATIONS OF\nINTEREST\n\nMINIMIZE\nCOMPENSATION, DYE\nSPREAD & COMPLEXITY" + }, + { + "id": 176625, + "strid": "d69bff39-d264-4898-a5a1-03e43b8deedd", + "image_id": 207393, + "image_name": "8009.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1370.134, + 3405.535, + 488.328, 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Harder\nFamily, Robert W. Franz, Lynn and Jack Loacker,\nProvidence Health & Services, UbiVac and\nPrometheus Labs." + }, + { + "id": 86443, + "strid": "6340e16b-9d07-412b-b52c-cdcf75e268b6", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 76.93, + 399.63, + 225.07999999999998, + 302.70000000000005 + ], + "priority": -1, + "parents": [], + "children": [ + 86395, + 86394, + 86433, + 86418, + 86442, + 86401, + 86431, + 86396, + 86393 + ], + "area": 30743.535900000003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86393, + "strid": "2658c4ed-798f-4df7-a274-7d48bca7cd8f", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 331.145, + 72.468, + 2129.961, + 247.449 + ], + "priority": 1, + "parents": [ + 86443 + ], + "children": [], + "area": 23997.41586, + "iscrowd": 0, + "segmentation": [], + "text": "Phaff Yeast.Gulture Collection:\nNew Discoveries from an. Old Collection" + }, + { + "id": 86394, + "strid": "1f98e0b7-7db2-4c44-80a3-787e6b909890", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 334.136, + 378.108, + 1261.716, + 274.641 + ], + "priority": 2, + "parents": [ + 86443 + ], + "children": [], + "area": 126339.494688, + "iscrowd": 0, + "segmentation": [], + "text": "Kyria Boundy-Mills,PhD, Curator since 1999, klbmills @ucdavis.edu\nLuis Antonio GarayAlmada, PhD Student, Igaray@ucdavis.edu\nIrnayuli R Sitepu,PhD, Postdoctoral fellow, irsitepu @ucdavis.edu\nFood Science and Technology, University of California Davis\n\nhttp://pNaftcollection.ucdavis.edu" + }, + { + "id": 86395, + "strid": "cdcfe7a8-a157-417b-a5bf-0f57024c9552", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 493.21, + 893.399, + 653.971, + 74.77800000000002 + ], + "priority": 3, + "parents": [ + 86443 + ], + "children": [ + 86413, + 86416, + 86414, + 86417, + 86411, + 86415, + 86400, + 86412 + ], + "area": 440633.32078999997, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 86400, + "strid": "c5c12db2-18be-478c-a132-85769333409c", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 350.452, + 1066.069, + 963.962, + 853.8339999999998 + ], + "priority": 4, + "parents": [ + 86395 + ], + "children": [], + "area": 373606.013188, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86412, + "strid": "29ee7bb8-0583-4dc6-9955-11f8c7bf5c6c", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 332.113, + 2016.518, + 403.62500000000006, + 309.47400000000016 + ], + "priority": 5, + "parents": [ + 86395 + ], + "children": [], + "area": 669711.842534, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86411, + "strid": "1da44cf4-0298-4272-85af-4a49eb17fbf8", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 776.983, + 1957.938, + 465.028, + 442.13700000000017 + ], + "priority": 6, + "parents": [ + 86395 + ], + "children": [], + "area": 1521284.541054, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86413, + "strid": "58f9f1a5-2cab-4046-afba-5c5663104c41", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 367.898, + 2425.293, + 845.0749999999999, + 105.97800000000007 + ], + "priority": 7, + "parents": [ + 86395 + ], + "children": [], + "area": 892260.4441140001, + "iscrowd": 0, + "segmentation": [], + "text": "Yeasts are stored at -80°C in duplicate.\nA third copy of the collection is being transferred to a remote\ncryopreservation facility in Fort Collins, Colorado operated by USDA." + }, + { + "id": 86414, + "strid": "5feb9fed-d22b-42b1-9e68-e0878e8de24a", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 328.18, + 2633.12, + 403.82700000000006, + 450.77800000000025 + ], + "priority": 8, + "parents": [ + 86395 + ], + "children": [], + "area": 864137.3216, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86417, + "strid": "a79cf449-6b0b-40be-860d-b7db17bdba7f", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 305.962, + 3123.099, + 573.935, + 137.63400000000001 + ], + "priority": 9, + "parents": [ + 86395 + ], + "children": [], + "area": 955549.616238, + "iscrowd": 0, + "segmentation": [], + "text": "Herman Phaff ahd\\fom Starmer collecting\nyeasts in theySenoran Desert, 1977. Most\nyeasts in the*collection were isolated in nature\nby,Phaff and colleagues." + }, + { + "id": 86415, + "strid": "96f45266-3625-4947-a59a-a938fae5d44d", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 784.012, + 2716.161, + 596.875, + 354.17700000000013 + ], + "priority": 10, + "parents": [ + 86395 + ], + "children": [], + "area": 2129502.817932, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86416, + "strid": "cf852041-67d7-4cdb-ab70-9979a9d732e4", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 930.823, + 3107.959, + 370.236, + 134.88200000000006 + ], + "priority": 11, + "parents": [ + 86395 + ], + "children": [], + "area": 2892959.7202569996, + "iscrowd": 0, + "segmentation": [], + "text": "Red stars: Locations sampled\nby Phaff. Blue stars: Origin of\nyeasts obtained from other\nresearchers and collections." + }, + { + "id": 86418, + "strid": "ea172315-684a-4888-a78d-20ea68a65f26", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 662.436, + 3408.002, + 250.495, + 64.6880000000001 + ], + "priority": 12, + "parents": [ + 86443 + ], + "children": [ + 86419, + 86422, + 86420, + 86423, + 86421 + ], + "area": 2257583.212872, + "iscrowd": 0, + "segmentation": [], + "text": "Services" + }, + { + "id": 86420, + "strid": "1660c2bf-7d86-414f-a840-a77b10c127e0", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 315.597, + 3599.314, + 300.043, + 35.784999999999854 + ], + "priority": 13, + "parents": [ + 86418 + ], + "children": [], + "area": 1135932.700458, + "iscrowd": 0, + "segmentation": [], + "text": "Strain distribution:" + }, + { + "id": 86419, + "strid": "c79731ef-3819-4ee1-8582-fa8e1f09c653", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 312.844, + 3641.981, + 984.086, + 609.7199999999998 + ], + "priority": 14, + "parents": [ + 86418 + ], + "children": [], + "area": 1139371.903964, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86423, + "strid": "ee54e2a0-01eb-4e74-9567-1b34370017f2", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 315.953, + 4302.874, + 154.202, + 36.837000000000444 + ], + "priority": 15, + "parents": [ + 86418 + ], + "children": [], + "area": 1359505.948922, + "iscrowd": 0, + "segmentation": [], + "text": "Expertise" + }, + { + "id": 86422, + "strid": "7dec8259-86fd-4887-96ec-c991d29a47b7", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 314.24, + 4350.849, + 806.992, + 124.21900000000005 + ], + "priority": 16, + "parents": [ + 86418 + ], + "children": [], + "area": 1367210.78976, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86421, + "strid": "696578e9-4e8f-484b-975c-88cdd171dbcf", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 314.24, + 4522.185, + 988.608, + 125.07499999999982 + ], + "priority": 17, + "parents": [ + 86418 + ], + "children": [], + "area": 1421051.4144000001, + "iscrowd": 0, + "segmentation": [], + "text": "Strain deposit\nYeast strains are accepted for deposit and distribution if they meet\nthe mission of the collectionvand/are of interest to collection users." + }, + { + "id": 86396, + "strid": "6b77f3bf-52fe-4fa8-ac66-b767d741514f", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1662.473, + 703.054, + 592.7889999999998, + 63.902000000000044 + ], + "priority": 18, + "parents": [ + 86443 + ], + "children": [ + 86398, + 86399, + 86397 + ], + "area": 1168808.2925419998, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 86397, + "strid": "058725e2-63b5-44a4-9af2-d59e355c220e", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1440.857, + 832.217, + 1026.504, + 168.591 + ], + "priority": 19, + "parents": [ + 86396 + ], + "children": [], + "area": 1199105.689969, + "iscrowd": 0, + "segmentation": [], + "text": "Of the 1600 known species of yeast, the genomes of over 60 species\nhave been sequenced, with many more underway. Twenty three of\nthese strains are available from the Phaff collection (UCDFST). More\nare currently being used in.the 1000 Fungal Genomes project." + }, + { + "id": 86398, + "strid": "0f330f2a-cace-4c03-a4d9-b45ddf96fe0c", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1429.98, + 1055.193, + 1045.538, + 719.232 + ], + "priority": 20, + "parents": [ + 86396 + ], + "children": [], + "area": 1508904.88614, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86399, + "strid": "6b9d3959-1a2e-4f63-96a3-0db46ee7e44a", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1438.138, + 1807.055, + 938.1289999999999, + 157.71399999999994 + ], + "priority": 21, + "parents": [ + 86396 + ], + "children": [], + "area": 2598794.46359, + "iscrowd": 0, + "segmentation": [], + "text": "Culture collection identifiers:\n\nUCDEST: Phaff Yeast Culture Collection, University of California Davis\n\nNRRL: USDA-ARS Culture CollectionyPeoria, Iky USA\n\nATCC: American Type Culture Collection, Manassas, VA, USA\n\nEX-F: Culture Collection of Extremophili¢ Fungi, Department of Biology, University of Ljubljana, Slovenia\nCBS: Centraalbureau voor Schimmelcultures, Utrecht, The Netherlands" + }, + { + "id": 86401, + "strid": "d791cf7b-7bb1-409e-84fa-1224a3b5f342", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1574.952, + 2101.852, + 763.8709999999999, + 56.429999999999836 + ], + "priority": 22, + "parents": [ + 86443 + ], + "children": [ + 86427, + 86409, + 86405, + 86429, + 86425, + 86426, + 86408, + 86404, + 86428, + 86407, + 86406, + 86410, + 86403, + 86424 + ], + "area": 3310316.011104, + "iscrowd": 0, + "segmentation": [], + "text": "—_" + }, + { + "id": 86408, + "strid": "9600ca92-b0bd-4d75-96b7-b905fdda3c4e", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1499.253, + 2534.024, + 341.3330000000001, + 349.5909999999999 + ], + "priority": 23, + "parents": [ + 86401 + ], + "children": [ + 86402 + ], + "area": 3799143.084072, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86402, + "strid": "5434ff8f-0664-46b3-8af8-1b34c2339075", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1516.094, + 2224.952, + 346.85300000000007, + 262.1199999999999 + ], + "priority": 24, + "parents": [ + 86408 + ], + "children": [], + "area": 3373236.3774880003, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 86406, + "strid": "f78d1cfb-ae9c-4cd4-ab37-7c146f031bed", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1504.758, + 2908.389, + 390.88200000000006, + 100.47299999999996 + ], + "priority": 25, + "parents": [ + 86401 + ], + "children": [], + "area": 4376421.614862001, + "iscrowd": 0, + "segmentation": [], + "text": "Drosophila‘suzukii infests fruits\nand carries specific yeasts\n(Hamby et al. 2012)" + }, + { + "id": 86403, + "strid": "bb7d1ca5-a7b0-4454-bd93-011a7358d26f", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1908.027, + 2278.024, + 523.011, + 169.28999999999996 + ], + "priority": 26, + "parents": [ + 86401 + ], + "children": [], + "area": 4346531.298648, + "iscrowd": 0, + "segmentation": [], + "text": "In three expeditionsojthe.island of\nSulawesi, Indonesia (2009-2011), we\ncollected 1800 miéfobes (bacteria, yeasts\nand filamentous*ungi) from wood-feeding\nbeetle larvaeNplant surfaces, and soil." + }, + { + "id": 86409, + "strid": "d539645f-3812-487f-9f75-08f87af5457b", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2033.031, + 2558.056, + 404.9319999999998, + 310.9870000000001 + ], + "priority": 27, + "parents": [ + 86401 + ], + "children": [], + "area": 5200607.147736, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86405, + "strid": "f5123bc7-5994-477e-b4ae-9b735f680f7e", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1979.597, + 2908.389, + 484.4730000000002, + 101.84999999999991 + ], + "priority": 28, + "parents": [ + 86401 + ], + "children": [], + "area": 5757438.139233001, + "iscrowd": 0, + "segmentation": [], + "text": "Olive spoilage is caused by pectinolytic\nSaccharomyces cerevisiae\n(Golomb et al. 2012)" + }, + { + "id": 86410, + "strid": "9e10e70b-b56b-4eb6-a3a9-d728cd5c9072", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1496.997, + 3126.998, + 345.9839999999999, + 163.98799999999983 + ], + "priority": 29, + "parents": [ + 86401 + ], + "children": [], + "area": 4681106.6250060005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86407, + "strid": "0ec3ea9f-046e-4af2-8975-e8833184e068", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1495.124, + 3308.905, + 339.9570000000001, + 35.784999999999854 + ], + "priority": 30, + "parents": [ + 86401 + ], + "children": [], + "area": 4947223.279220001, + "iscrowd": 0, + "segmentation": [], + "text": "Exponentially growing cells" + }, + { + "id": 86428, + "strid": "0b032123-4542-41dc-830d-7250284e8c70", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1495.965, + 3381.139, + 354.13200000000006, + 399.6880000000001 + ], + "priority": 31, + "parents": [ + 86401 + ], + "children": [], + "area": 5058065.604135, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86426, + "strid": "d7d56d3f-d8f0-45ce-9f5a-4d09077a6c20", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1396.512, + 3795.435, + 543.991, + 171.33599999999979 + ], + "priority": 32, + "parents": [ + 86401 + ], + "children": [], + "area": 5300370.52272, + "iscrowd": 0, + "segmentation": [], + "text": "The same(Culture sampled in stationary\nphasé. These yeasts contain 57% oil as\nTAGs. Oilfrom Phaff collection yeasts could\nbe used to make biodiesel and other\nchemicals." + }, + { + "id": 86404, + "strid": "f6c8c9e4-e8fd-46fc-8ded-cf0f4a4d3f53", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2015.382, + 3058.411, + 465.2040000000002, + 165.16100000000006 + ], + "priority": 33, + "parents": [ + 86401 + ], + "children": [], + "area": 6163866.478002001, + "iscrowd": 0, + "segmentation": [], + "text": "Oleaginous (high oil) yeasts can\naccumulate 65% gil\\by-dry weight.\nThere were 40/known oleaginous\n\nyeast species,in\\2011; we discovered\n17 more.(Sitepu et al. 2013)" + }, + { + "id": 86429, + "strid": "0d42dbd3-4629-4696-af88-0884236d40cc", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2080.995, + 3286.041, + 302.0050000000001, + 467.99699999999984 + ], + "priority": 34, + "parents": [ + 86401 + ], + "children": [], + "area": 6838234.890795, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86427, + "strid": "a6101b70-7306-45f9-b69b-06b9984fb5e6", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2006.182, + 3791.151, + 488.307, + 129.92999999999984 + ], + "priority": 35, + "parents": [ + 86401 + ], + "children": [], + "area": 7605738.895482, + "iscrowd": 0, + "segmentation": [], + "text": "Some Phaff collection yeasts\nsynthesize and secrete extracellular oil\nas glycolipids. These glycolipids are\nenvironmentally-friendly:biosurfactants." + }, + { + "id": 86425, + "strid": "92c312b6-e456-4867-84c1-b35a0949be9d", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1313.699, + 4163.807, + 384.078, + 238.442 + ], + "priority": 36, + "parents": [ + 86401 + ], + "children": [], + "area": 5469989.092093, + "iscrowd": 0, + "segmentation": [], + "text": "Boundy-Mills lab members:\nPostdoc: Irnayuli Sitepu\nPhD Student: Tonio Garay\nJunior Specialist: Erin Cathcart\nUndergraduates: Ting Lin,\nShuang Shi, Joe Williams, Jen\nLincoln, Idelia Chandra" + }, + { + "id": 86424, + "strid": "967d6bd8-11d8-4242-ab80-56aeb380ebec", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1725.136, + 3983.12, + 740.7440000000001, + 641.0439999999999 + ], + "priority": 37, + "parents": [ + 86401 + ], + "children": [], + "area": 6871423.70432, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86442, + "strid": "356fe329-87ea-456c-9230-966151d9034e", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2941.352, + 491.706, + 298.52999999999975, + 66.95000000000005 + ], + "priority": 38, + "parents": [ + 86443 + ], + "children": [ + 86435, + 86437, + 86441, + 86436, + 86439, + 86438, + 86440, + 86434 + ], + "area": 1446280.426512, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 86438, + "strid": "40453ca0-4dac-4d48-aaa8-fff07c3c5444", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2585.75, + 633.289, + 935.1019999999999, + 196.45900000000006 + ], + "priority": 39, + "parents": [ + 86442 + ], + "children": [], + "area": 1637527.03175, + "iscrowd": 0, + "segmentation": [], + "text": "jectsare designed to build th\nboth. Funds come from f\n\nResearch and screening\ncollection, tap the collection\nstate, and industry sources}\n\nYeast ecology" + }, + { + "id": 86440, + "strid": "dd0bd677-dccb-497e-bb22-57defd0c0668", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2590.14, + 834.138, + 584.9879999999998, + 199.75200000000007 + ], + "priority": 40, + "parents": [ + 86442 + ], + "children": [], + "area": 2160534.19932, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86439, + "strid": "89e721f8-e584-4e05-9944-2519ee901d58", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2589.043, + 1075.597, + 134.99699999999984, + 30.730999999999995 + ], + "priority": 41, + "parents": [ + 86442 + ], + "children": [], + "area": 2784766.883671, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 86441, + "strid": "1ca58346-8c3f-4184-b63a-d439e9bb748a", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2590.14, + 1112.913, + 921.9320000000002, + 204.14200000000005 + ], + "priority": 42, + "parents": [ + 86442 + ], + "children": [], + "area": 2882600.4778199997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86437, + "strid": "d27f1eb7-a303-4915-8814-b6828d1f3397", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2645.4, + 1372.475, + 747.9949999999999, + 884.2629999999999 + ], + "priority": 43, + "parents": [ + 86442 + ], + "children": [], + "area": 3630745.3649999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86436, + "strid": "8b35ca11-75b1-43ad-b6e3-e032526220e1", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2684.043, + 2290.969, + 663.6509999999998, + 100.33199999999988 + ], + "priority": 44, + "parents": [ + 86442 + ], + "children": [], + "area": 6149059.307667, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86435, + "strid": "da595200-4af3-4170-9449-75d291ba3d79", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2550.268, + 2455.053, + 907.1639999999998, + 508.97299999999996 + ], + "priority": 45, + "parents": [ + 86442 + ], + "children": [], + "area": 6261043.104204, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 86434, + "strid": "6dc79a34-77d7-42ec-b2f7-515d1dfd2abc", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2573.261, + 2999.56, + 853.8620000000001, + 181.8510000000001 + ], + "priority": 46, + "parents": [ + 86442 + ], + "children": [], + "area": 7718650.76516, + "iscrowd": 0, + "segmentation": [], + "text": "168 yeast strains, including 34 S. cerevisiae strains, weré“cultivated in media\nwith 1-ethyl-3-methylimidazolium acetate to test toléran¢e/of yeast to ionic\nliquid. lonic liquid residue after pretreatment of biomass can inhibit\ndownstream microorganism activity. Heat map»ef Amax values presents\nyeast growth performance, darker color indicate a better growth. Diagonal\nhatching indicates ionic levels,that were not tested." + }, + { + "id": 86431, + "strid": "ad385e63-b015-4bb4-bcb2-2a362c57cb0e", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2917.105, + 4280.877, + 560.1839999999997, + 71.06800000000021 + ], + "priority": 47, + "parents": [ + 86443 + ], + "children": [ + 86430 + ], + "area": 12487767.701085001, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgments" + }, + { + "id": 86430, + "strid": "9599ad1f-d157-4456-a676-f04af291e748", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2703.901, + 4381.208, + 838.1860000000001, + 366.83700000000044 + ], + "priority": 48, + "parents": [ + 86431 + ], + "children": [], + "area": 11846352.692408, + "iscrowd": 0, + "segmentation": [], + "text": "Collection maintenance: Erin Cathcart\n\nLipid studies: Tonio Garay, Irnayuli Sitepu, Bruce German,\nAnnaliese Franz, Oliver Fiehn, Jean VanderGheynst\n\nScreening work: Chris Simmons, Tina Jeoh, Dave Block, Ting Lin,\nErin Cathcart, Jennifer Lincoln, Idelia Chandra, Joseph Williams,\nShuang Shi, Shanny Krisna, Vania Rahardjo, Katherine Neuhaus\n\nFunding: Sloan foundation, Industrial partner, CONACYT,\nNIH/USDA/NSF/DOE, NSF, CDFA" + }, + { + "id": 86433, + "strid": "d7c37b00-afdf-4c20-969f-4d37726b7885", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2902.473, + 3325.637, + 333.39300000000003, + 57.48199999999997 + ], + "priority": 49, + "parents": [ + 86443 + ], + "children": [ + 86432 + ], + "area": 9652571.600301001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 86432, + "strid": "8eab4cda-6d01-4919-b2b2-7ae05fc43d74", + "image_id": 203863, + "image_name": "121061.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2572.216, + 3482.405, + 981.3669999999997, + 713.8169999999996 + ], + "priority": 50, + "parents": [ + 86433 + ], + "children": [], + "area": 8957497.859480001, + "iscrowd": 0, + "segmentation": [], + "text": "Sitepu, IR,(Shi*S, Simmons BA, Singer SW, Boundy-Mills\nYeast/ tolerance to the ionic liquid 1-ethyl-3-methylimi\nSubmitted manuscript.\n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n‘olium acetate\n\nSitepu, IR, Selby T, Zhu S, Lin T, Boundy-Mills K.\nutilization and inhibitor tolerance of 45 oleaginous y\nIndustrial Microbiology and Biotechnology DOI 10.1\n\nA. Carbon, source\nspeciés, Journal of\n/310295-014-1447-y\n\nGolomb BL, Morales V, Jung A, Yau B, Boundy-\nEffects of pectinolytic yeast on the microbial\nolive fermentations. Food Microbiology 33 (1):\n\nIs K\\Mafco ML. 2012.\nposition and spoilage of\n06\n\nHamby KA, Hernandez A, Boundy-Mills K,\nyeasts with spotted-wing Drosophil\nDrosophilidae) in cherries and rasp\nMicrobiology 78 (14):4869-4873\n\nim FG. 2012. Associations of\nrosophila suzukii; Diptera:\nles. 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datasets.\nEfficiently use any computing platform." + }, + { + "id": 110082, + "strid": "89c1bc66-c503-4425-902b-47394d13d245", + "image_id": 204771, + "image_name": "13048.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 41.333, + 762.104, + 408.38300000000004, + 96.75 + ], + "priority": 6, + "parents": [ + 110083 + ], + "children": [], + "area": 31500.044632, + "iscrowd": 0, + "segmentation": [], + "text": "Portability:\nEasily execute analysis on a different\nsystem/platform/architecture." + }, + { + "id": 110085, + "strid": "ebe691fd-c449-4615-9f82-f3b1428389ac", + "image_id": 204771, + "image_name": "13048.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 815.399, + 427.939, + 886.0750000000002, + 471.252 + ], + "priority": 7, + "parents": [ + 110083 + ], + "children": [], + "area": 348941.03266100003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 110093, + "strid": "43bee472-635a-4dfe-9db2-65aa666c0935", + "image_id": 204771, + 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"parents": [ + 110099 + ], + "children": [], + "area": 70092.600858, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 110096, + "strid": "743737be-c96a-45dd-bae8-c5d33dbdae3c", + "image_id": 204771, + "image_name": "13048.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 591.68, + 1979.503, + 524.9120000000001, + 268.63199999999983 + ], + "priority": 21, + "parents": [ + 110099 + ], + "children": [], + "area": 1171232.3350399998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 110098, + "strid": "912ffa4c-c808-405c-827c-24e1f8ddb37d", + "image_id": 204771, + "image_name": "13048.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1204.592, + 2004.204, + 395.22800000000007, + 197.6139999999998 + ], + "priority": 22, + "parents": [ + 110099 + ], + "children": [], + "area": 2414248.104768, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 152625, + "strid": "3a61151d-3f38-4cd7-acd8-d33c8892b55d", + "image_id": 206441, + "image_name": "21455.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 711.27, + 65.75, + 195.12, + 170.11 + ], + "priority": -1, + "parents": [], + "children": [ + 152605, + 152601, + 152599, + 152604, + 152603, + 152602, + 152600, + 152606 + ], + "area": 46766.0025, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 152599, + "strid": "1a2a44fb-b2d7-4730-9558-f4d5a6c607f6", + "image_id": 206441, + "image_name": "21455.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 1059.801, + 31.076, + 2942.906, + 218.322 + ], + "priority": 1, + "parents": [ + 152625 + ], + "children": [], + "area": 32934.375876, + "iscrowd": 0, + "segmentation": [], + "text": "Transcriptomic profile of drought-responsive pathways in Oryza sativa:\na meta-analysis" + }, + { + "id": 152600, + "strid": "44a97140-e955-4beb-bd28-841f4fdba752", + "image_id": 206441, + "image_name": "21455.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1360.895, + 271.758, + 2313.598, + 165.22999999999996 + ], + "priority": 2, + "parents": [ + 152625 + ], + "children": [], + "area": 369834.10341, + "iscrowd": 0, + "segmentation": [], + "text": "Maria Kampa“*, Konstantinos Makropoulos!*, Panagiota Kontou2, Pantelis Bagos!, Georgia Braliou2”\n\n1Department of Computer Science and Biomedical Informatics, University of Thessaly, Lamia, Greece, 7Department of Mathematics, University of Thessaly, Lamia, Greece\n“Corresponding author: gbraliou@uth.gr, *Equally contributing authors" + }, + { + "id": 152601, + "strid": "0ba4cf32-a93b-459e-b916-f8be6c64f126", + "image_id": 206441, + "image_name": "21455.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 249.34, + 482.658, + 359.649, + 45.62099999999998 + ], + "priority": 3, + "parents": [ + 152625 + ], + "children": [ + 152607 + ], + "area": 120345.94572, + "iscrowd": 0, + "segmentation": [], + "text": "A. Introduction" + }, + { + "id": 152607, + "strid": "48df86fa-68aa-4ffd-9af6-025a3f3d5fb9", + "image_id": 206441, + "image_name": "21455.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 26.441, + 549.914, + 810.119, + 546.3880000000001 + ], + "priority": 4, + "parents": [ + 152601 + ], + "children": [], + "area": 14540.276074, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 152602, + "strid": "0124f235-77da-4f25-95ac-60e058bc53d8", + "image_id": 206441, + "image_name": "21455.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 286.856, + 1129.459, + 286.68000000000006, + 45.162000000000035 + ], + "priority": 5, + "parents": [ + 152625 + ], + "children": [ + 152608, + 152609 + ], + "area": 323992.090904, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 152608, + "strid": "e144b533-771c-4132-a46c-69e5607106be", + "image_id": 206441, + "image_name": "21455.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 29.538, + 1196.984, + 809.237, + 796.565 + ], + "priority": 6, + "parents": [ + 152602 + ], + "children": [], + "area": 35356.513392, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 152609, + "strid": "11d2af63-c77d-4678-8d80-519a8cdd93af", + "image_id": 206441, + "image_name": "21455.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 32.548, + 2021.142, + 802.701, + 841.414 + ], + "priority": 7, + "parents": [ + 152602 + ], + "children": [ + 152610 + ], + "area": 65784.129816, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 152610, + "strid": "6670e04f-d6fa-4228-a329-6599d5991f46", + "image_id": 206441, + "image_name": "21455.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 27.101, + 2882.539, + 808.134, + 111.32999999999993 + ], + "priority": 8, + "parents": [ + 152609 + ], + "children": [], + "area": 78119.68943900001, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. PRISMA flow diagram representing the stages\nduring the systematic reviewing process for study\ncollection." + }, + { + "id": 152603, + "strid": "7f03b6bd-e7b2-4400-b174-c98976e31b33", + "image_id": 206441, + "image_name": "21455.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1613.082, + 482.805, + 247.5329999999999, + 45.627999999999986 + ], + "priority": 9, + "parents": [ + 152625 + ], + "children": [ + 152616, + 152618, + 152613, + 152615, + 152611 + ], + "area": 778804.05501, + "iscrowd": 0, + "segmentation": [], + "text": "C. Results" + }, + { + "id": 152611, + "strid": "793d28dd-7d83-4898-ad9e-7df918c303ec", + "image_id": 206441, + "image_name": "21455.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 866.874, + 550.481, + 1746.8799999999999, + 494.2639999999999 + ], + "priority": 10, + "parents": [ + 152603 + ], + "children": [], + "area": 477197.666394, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 152613, + "strid": "9bcfcd23-874e-4faf-b8da-1256549d4252", + "image_id": 206441, + "image_name": "21455.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 857.433, + 1134.772, + 1764.4449999999997, + 643.4369999999999 + ], + "priority": 11, + "parents": [ + 152603 + ], + "children": [ + 152612 + ], + "area": 972990.960276, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 152612, + "strid": "2eb3a70d-6d28-4d4b-b821-69de74adc049", + "image_id": 206441, + "image_name": "21455.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 857.904, + 1088.38, + 1755.663, + 44.39499999999998 + ], + "priority": 12, + "parents": [ + 152613 + ], + "children": [], + "area": 933725.55552, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1. Summary results of analysis and meta-analysis of six individual studies using MAGE tool (FDR 0,005)." + }, + { + "id": 152615, + "strid": "a372788a-efb4-42b4-9341-4afde18d3f40", + "image_id": 206441, + "image_name": "21455.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 862.452, + 1918.709, + 1670.403, + 1058.8119999999997 + ], + "priority": 13, + "parents": [ + 152603 + ], + "children": [ + 152614 + ], + "area": 1654794.414468, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 152614, + "strid": "18279d95-2a01-431f-a37d-94cd72c9d2fa", + "image_id": 206441, + "image_name": "21455.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 862.492, + 1821.99, + 1668.485, + 85.71499999999992 + ], + "priority": 14, + "parents": [ + 152615 + ], + "children": [], + "area": 1571451.79908, + "iscrowd": 0, + "segmentation": [], + "text": "able 2. Pathway Enrichment Analysis Results. Top five pathways according to GO:MF-Molecular\nunction, GO:BP-Biological Process, GO:CC-Cellular Component, KEGG." + }, + { + "id": 152616, + "strid": "3fb03e44-f083-4c29-b3ca-ac0afd4088c8", + "image_id": 206441, + "image_name": "21455.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2648.865, + 481.809, + 1650.1409999999996, + 1280.436 + ], + "priority": 15, + "parents": [ + 152603 + ], + "children": [ + 152617 + ], + "area": 1276246.996785, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 152617, + "strid": "24e1e786-94b5-481c-8a3a-c2f06d50dac3", + "image_id": 206441, + "image_name": "21455.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2654.544, + 1778.034, + 1640.1419999999998, + 120.779 + ], + "priority": 16, + "parents": [ + 152616 + ], + "children": [], + "area": 4719869.486496, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3. STRING Protein-Protein Interaction Network corresponding to seedling-shoot tissue DEGs. The network consists\nof 105 nodes at a 0.4 interaction score. Edges indicate experimentally determined P-P interactions. Red squares highlight\nthe top six highly connected nodes." + }, + { + "id": 152618, + "strid": "72f74c37-e7b9-4cb4-b8bf-24ee972e9715", + "image_id": 206441, + "image_name": "21455.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2551.921, + 1907.961, + 1053.0210000000002, + 911.1209999999999 + ], + "priority": 17, + "parents": [ + 152603 + ], + "children": [ + 152619 + ], + "area": 4868965.743081, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 152619, + "strid": "b29928f0-eaa7-4eb3-9274-76a90e2f8cab", + "image_id": 206441, + "image_name": "21455.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2558.49, + 2834.442, + 1039.703, + 154.96100000000024 + ], + "priority": 18, + "parents": [ + 152618 + ], + "children": [], + "area": 7251891.51258, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2. Venn diagram illustrating the DEGs between the meta-analysis and\nthe six individual studies which we retrieved from GEO database. In green\ncontrast are DEGs discovered through the meta-analysis but not in any of\nthe primary investigations." + }, + { + "id": 152604, + "strid": "ea78b1b6-4ee5-4851-9902-cf959aa5e29c", + "image_id": 206441, + "image_name": "21455.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4627.468, + 485.851, + 348.2489999999998, + 44.72500000000002 + ], + "priority": 19, + "parents": [ + 152625 + ], + "children": [ + 152622, + 152620 + ], + "area": 2248259.955268, + "iscrowd": 0, + "segmentation": [], + "text": "D. Conclusions" + }, + { + "id": 152620, + "strid": "a7803e79-0c49-4b40-b48d-99c5b6ba45ea", + "image_id": 206441, + "image_name": "21455.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 4333.767, + 549.162, + 935.3119999999999, + 1367.876 + ], + "priority": 20, + "parents": [ + 152604 + ], + "children": [], + "area": 2379940.153254, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 152622, + "strid": "26423d69-6f65-42a3-8b1e-661428dcf50a", + "image_id": 206441, + "image_name": "21455.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 3622.325, + 2038.395, + 1657.393, + 691.3299999999999 + ], + "priority": 21, + "parents": [ + 152604 + ], + "children": [ + 152621 + ], + "area": 7383729.168374999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 152621, + "strid": "53a6598b-e3c8-41e8-aa3a-c36118cd9dd7", + "image_id": 206441, + "image_name": "21455.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 3625.122, + 1964.312, + 1631.511, + 46.430000000000064 + ], + "priority": 22, + "parents": [ + 152622 + ], + "children": [], + "area": 7120870.646063999, + "iscrowd": 0, + "segmentation": [], + "text": "Table 3. List of 6 hub genes and their protein functions. The arrow (fT!) indicates up/down-regulation" + }, + { + "id": 152605, + "strid": "d58a8bac-54bd-4344-9aa9-79e4bfaad202", + "image_id": 206441, + "image_name": "21455.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3723.797, + 2779.264, + 700.77, + 46.33199999999988 + ], + "priority": 23, + "parents": [ + 152625 + ], + "children": [ + 152623 + ], + "area": 10349414.945408, + "iscrowd": 0, + "segmentation": [], + "text": "D. Acknowledgements and Funding" + }, + { + "id": 152623, + "strid": "0affc395-55a1-4548-9363-6445f64bffe8", + "image_id": 206441, + "image_name": "21455.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3631.68, + 2836.119, + 888.2440000000001, + 152.35199999999986 + ], + "priority": 24, + "parents": [ + 152605 + ], + "children": [], + "area": 10299876.64992, + "iscrowd": 0, + "segmentation": [], + "text": "We acknowledge support by the projects: 1. “GENOMIC-OASIS: GENOMIC Analysis of Organisms of Agricultural and\nlivestock Interest in Sterea’, Grant Number (MIS) 5045902.The project IntDaMus (Code 3198) is implemented under the\n“ARISTEIA II” Action of the “OPERATIONAL PROGRAMME EDUCATION AND LIFELONG LEARNING” and is co-funded by the\nEuropean Social Fund (ESF) and National Resources.\n\n2. Operational Program \"STEREA ELLADA\" 2014 - 2020 (Strengthening of Research Projects, Technological Development\nand Innovation in the fields of RIS3) \"Molecular identification and exploitation of indigenous hop varieties for the\nproduction of high-quality beers with designation of origin-PAZL (Production Analysis of Hop Beers)-STER1-0026139\"" + }, + { + "id": 152606, + "strid": "79531518-9e7a-4fff-a885-42c5f675c58d", + "image_id": 206441, + "image_name": "21455.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4758.036, + 2777.23, + 301.66499999999996, + 42.73199999999997 + ], + "priority": 25, + "parents": [ + 152625 + ], + "children": [ + 152624 + ], + "area": 13214160.32028, + "iscrowd": 0, + "segmentation": [], + "text": "D. References" + }, + { + "id": 152624, + "strid": "0da9d829-ac37-4c4d-bdf7-93a743122130", + "image_id": 206441, + "image_name": "21455.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 4541.844, + 2838.058, + 733.7259999999997, + 124.71300000000019 + ], + "priority": 26, + "parents": [ + 152606 + ], + "children": [], + "area": 12890016.698952, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 175552, + "strid": "ac2906f4-8019-42f5-bae4-251aa105cc07", + "image_id": 207355, + "image_name": "7448.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 603.8, + 133.64, + 411.5300000000001, + 199.12 + ], + "priority": -1, + "parents": [], + "children": [ + 175549, + 175539, + 175551, + 175540, + 175538, + 175541, + 175545, + 175543, + 175548, + 175542, + 175546, + 175547 + ], + "area": 80691.83199999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 175538, + "strid": "d5f146d9-2f3e-48ce-b872-851b03fd4104", + "image_id": 207355, + "image_name": "7448.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 1350.861, + 98.988, + 848.3129999999999, + 149.642 + ], + "priority": 1, + "parents": [ + 175552 + ], + "children": [], + "area": 133719.028668, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 175539, + "strid": "166074cc-8d79-40c9-a672-df09549890b5", + "image_id": 207355, + "image_name": "7448.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1252.237, + 291.779, + 1040.9859999999999, + 54.38099999999997 + ], + "priority": 2, + "parents": [ + 175552 + ], + "children": [], + "area": 365376.459623, + "iscrowd": 0, + "segmentation": [], + "text": "Pinho-Costa, Luis*; Sousa, Hélder* | *USF Fanzeres" + }, + { + "id": 175541, + "strid": "e2c13279-dd5d-43d9-b194-5d77d8c79fcb", + "image_id": 207355, + "image_name": "7448.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 137.466, + 419.973, + 623.24, + 886.4270000000001 + ], + "priority": 3, + "parents": [ + 175552 + ], + "children": [], + "area": 57732.008418000005, + "iscrowd": 0, + "segmentation": [], + "text": "Identificagao\n\nNome: M\n\nGénero: Masculino\n\nIdade: 58 anos\n\nEstado Civil: Casado\nActividade: Reformado\nNacionalidade: Portuguesa\nRaga: Caucasiana\n\nEscolaridade: 42 Classe" + }, + { + "id": 175542, + "strid": "c3fe0b28-7b1d-49dc-b80d-6fd8008ee2db", + "image_id": 207355, + "image_name": "7448.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 963.864, + 429.324, + 1147.987, + 879.624 + ], + "priority": 4, + "parents": [ + 175552 + ], + "children": [], + "area": 413809.947936, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 175543, + "strid": "3610e0f6-e149-4e31-8464-fa17b3fb1603", + "image_id": 207355, + "image_name": "7448.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2261.856, + 427.354, + 1147.1860000000001, + 853.6679999999999 + ], + "priority": 5, + "parents": [ + 175552 + ], + "children": [ + 175544 + ], + "area": 966613.2090240001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 175544, + "strid": "3e3093e3-98fd-4e70-acd5-8b52b6e7a1d5", + "image_id": 207355, + "image_name": "7448.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2273.121, + 1295.152, + 1080.15, + 43.80199999999991 + ], + "priority": 6, + "parents": [ + 175543 + ], + "children": [], + "area": 2944037.209392, + "iscrowd": 0, + "segmentation": [], + "text": "Tipo de Familia: Nuclear; Ciclo de Vida de Duvall: Fase VIII" + }, + { + "id": 175548, + "strid": "bfe772be-81be-4841-b04b-a1d90c7aed7d", + "image_id": 207355, + "image_name": "7448.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 133.66, + 1403.394, + 1010.4600000000002, + 63.315000000000055 + ], + "priority": 7, + "parents": [ + 175552 + ], + "children": [], + "area": 187577.64204, + "iscrowd": 0, + "segmentation": [], + "text": "Consulta Aberta (10 de junho de 2013)" + }, + { + "id": 175547, + "strid": "0eda8365-82ca-4ff1-a3e2-0495b132b476", + "image_id": 207355, + "image_name": "7448.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 144.453, + 1468.84, + 3263.237, + 615.7540000000001 + ], + "priority": 8, + "parents": [ + 175552 + ], + "children": [], + "area": 212178.34451999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 175546, + "strid": "c74dea18-a3e9-4f48-a49c-368c4619cb29", + "image_id": 207355, + "image_name": "7448.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 144.307, + 2129.836, + 3262.912, + 119.84299999999985 + ], + "priority": 9, + "parents": [ + 175552 + ], + "children": [], + "area": 307350.2436519999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 175545, + "strid": "46261a67-dfd7-45ff-b8f0-1ae363371608", + "image_id": 207355, + "image_name": "7448.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 144.469, + 2286.802, + 3272.943, + 580.076 + ], + "priority": 10, + "parents": [ + 175552 + ], + "children": [], + "area": 330371.998138, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 175549, + "strid": "3831fa88-47fd-4fc4-92ed-943c93f4153b", + "image_id": 207355, + "image_name": "7448.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 164.794, + 3075.139, + 1509.517, + 1154.469 + ], + "priority": 11, + "parents": [ + 175552 + ], + "children": [], + "area": 506764.45636600006, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 175540, + "strid": "7d0e6866-907d-4507-aa35-a720ccb1b1c1", + "image_id": 207355, + "image_name": "7448.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1780.32, + 2951.997, + 340.11800000000017, + 76.9670000000001 + ], + "priority": 12, + "parents": [ + 175552 + ], + "children": [ + 175550 + ], + "area": 5255499.29904, + "iscrowd": 0, + "segmentation": [], + "text": "DISCUSSAO" + }, + { + "id": 175550, + "strid": "7bb03e47-0783-4a96-86fe-251426c8b933", + "image_id": 207355, + "image_name": "7448.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1780.46, + 3076.532, + 1618.3050000000003, + 1157.5190000000002 + ], + "priority": 13, + "parents": [ + 175540 + ], + "children": [], + "area": 5477642.164720001, + "iscrowd": 0, + "segmentation": [], + "text": "Na sequéncia do AVC em 2010, o utente foi diagnosticado com FA.\nEnquanto que na prevencao primaria a indicacdo para hipocoagulacdao\noral depende da estratificacdo de risco, na prevencdao secundaria ela é\nsempre a terapéutica de eleig¢do: pacientes com FA e fatores de risco\nadicionais (como hipertensdo arterial, diabetes e AVC prévio) tém risco\nelevado de AVC isquémico — podendo atingir os 8% por ano — mas este\npode ser reduzido em mais de 2/3 com os hipocoagulantes orais. Por\nesse motivo o utente iniciou hipocoagulagdo 10 meses apos o evento.\n\nOs hipocoagulantes orais aumentam contudo a incidéncia de AVC\nhemorragico; embora a sobrehipocoagulacdo se associe a risco\nhemorragico mais elevado, a maioria dos episddios ocorre com INR\n\nterapéutico, como no presente caso." + }, + { + "id": 175551, + "strid": "71cbfd44-728c-4bcd-9fd8-2e58fe5a2d70", + "image_id": 207355, + "image_name": "7448.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 164.571, + 4272.084, + 3233.142, + 258.7619999999997 + ], + "priority": 14, + "parents": [ + 175552 + ], + "children": [], + "area": 703061.135964, + "iscrowd": 0, + "segmentation": [], + "text": "Os Meédicos de Familia, porque frequentemente se deparam com utentes com FA hipocoagulada, devem estar alerta e sensibilizados para o\nbalanco entre risco isquémico e risco hemorragico, por forma a reconhecer e orientar precocemente eventuais complicacgdes dos dois pdlos\n\npatoldgicos." + }, + { + "id": 169004, + "strid": "4d3e8290-2b5c-4247-91ab-e393e53a446b", + "image_id": 207101, + "image_name": "6962.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 282.45, + 16.5, + 90.52000000000004, + 45.26 + ], + "priority": -1, + "parents": [], + "children": [ + 168992, + 168991, + 168988, + 168989, + 168993, + 168990 + ], + "area": 4660.425, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 168988, + "strid": "0fcf2d6d-be02-45d6-b525-880fe21b9f2e", + "image_id": 207101, + "image_name": "6962.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 25.589, + 64.287, + 771.858, + 58.95 + ], + "priority": 1, + "parents": [ + 169004 + ], + "children": [], + "area": 1645.040043, + "iscrowd": 0, + "segmentation": [], + "text": "Brain responses to the perception of dyadic gaze imteractions:\nthe role of adult attachment." + }, + { + "id": 168989, + "strid": "2740033f-799a-4931-ac60-72c841fd4d8e", + "image_id": 207101, + "image_name": "6962.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 112.775, + 126.86, + 553.264, + 15.902000000000001 + ], + "priority": 2, + "parents": [ + 169004 + ], + "children": [], + "area": 14306.6365, + "iscrowd": 0, + "segmentation": [], + "text": "Maria Elena lannoni, Marco Cecchini, Anna Lucia Pandolfo, Paola Aceto & Carlo Lai" + }, + { + "id": 168990, + "strid": "c9ca5b03-ec28-42d8-9e3b-1827368870b3", + "image_id": 207101, + "image_name": "6962.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 12.813, + 164.572, + 85.052, + 14.099999999999994 + ], + "priority": 3, + "parents": [ + 169004 + ], + "children": [ + 168994 + ], + "area": 2108.661036, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 168994, + "strid": "082f2ad9-d959-4f43-9efa-b54b6ca4ac35", + "image_id": 207101, + "image_name": "6962.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 11.711, + 181.119, + 798.372, + 137.64199999999997 + ], + "priority": 4, + "parents": [ + 168990 + ], + "children": [], + "area": 2121.084609, + "iscrowd": 0, + "segmentation": [], + "text": "Eyes and gaze direction play an important role in sogial and non-verbal communication. Mutual gaze is crucial in the\nestablishing interpersonal relationships from, the birth [1]. Few studies investigated how the brain processes the gaze\ninteractions showing a specific effect of avoidant gaze [2,3]. The brain network involved in gaze processing showing that\naverted versus direct gaze increased Amygdala responsesg[4], probable neural correlate of the perception of an alert\nresponse. Others studies [5,6] found significantly greater activation in the parieto-frontal and in the posterior superior\ntemporal cortex as a correlate of biological motion and socially relevant gaze processing, Finally, it has been found that\ndifferent attachment styles showed different brain processes in front of emotional visual stimuli; particularly, the avoidant\nattachment style showed specific differences compared to the other styles [7] ?" + }, + { + "id": 168991, + "strid": "3511e113-c892-4e88-889f-a7bd12bc5996", + "image_id": 207101, + "image_name": "6962.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 11.059, + 317.991, + 29.755000000000003, + 12.920000000000016 + ], + "priority": 5, + "parents": [ + 169004 + ], + "children": [ + 168995 + ], + "area": 3516.6624689999994, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 168995, + "strid": "5f752e38-23db-4d7c-a1e4-97055c80c9c1", + "image_id": 207101, + "image_name": "6962.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 10.629, + 334.506, + 798.579, + 51.605999999999995 + ], + "priority": 6, + "parents": [ + 168991 + ], + "children": [], + "area": 3555.4642739999995, + "iscrowd": 0, + "segmentation": [], + "text": "Aim of the present study was to investigate the time course of brain processes involved in the visual perception of different\ngaze interactions in woman-child dyads and the association between attachment dimensions and brain activation during\nthe presentation of gaze interactions by using ERP and sLORET.A methodology." + }, + { + "id": 168992, + "strid": "55ceb18b-bb87-4c2d-8344-11fd3604843c", + "image_id": 207101, + "image_name": "6962.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 11.585, + 387.632, + 53.31199999999999, + 14.055999999999983 + ], + "priority": 7, + "parents": [ + 169004 + ], + "children": [ + 168996, + 169001 + ], + "area": 4490.71672, + "iscrowd": 0, + "segmentation": [], + "text": "Method" + }, + { + "id": 168996, + "strid": "0b318148-5d3c-4c77-aa39-ff214c055af3", + "image_id": 207101, + "image_name": "6962.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 11.927, + 404.423, + 408.05, + 153.99900000000002 + ], + "priority": 8, + "parents": [ + 168992 + ], + "children": [], + "area": 4823.553121, + "iscrowd": 0, + "segmentation": [], + "text": "Participants\n44 healthy female subjects (Age M\nProcedure >\n\nThe visual stimuli consisted of 40 color digital images of\ncouples “woman-newborn” (Fig.1).\n\nParticipants completed the Attachment Style Questionnaire\n(ASQ), before EEG task; subsequently, EEG was recorded\ncontinuously at 250 Hz using Net Station 4.5.1 and a 256 lead\nHydrocel Geodesic Sensor Net." + }, + { + "id": 169001, + "strid": "9ea0ac84-e0b6-48ab-bddf-e9c27681a6d6", + "image_id": 207101, + "image_name": "6962.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 429.021, + 407.918, + 388.27400000000006, + 133.93399999999997 + ], + "priority": 9, + "parents": [ + 168992 + ], + "children": [ + 168998 + ], + "area": 175005.388278, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 168998, + "strid": "5d27f62d-1f63-4575-961a-39eb3d74f01f", + "image_id": 207101, + "image_name": "6962.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 551.407, + 549.637, + 154.20799999999997, + 11.25 + ], + "priority": 10, + "parents": [ + 169001 + ], + "children": [], + "area": 303073.689259, + "iscrowd": 0, + "segmentation": [], + "text": "Figen etre ot tar penne et [brat terme oe" + }, + { + "id": 168993, + "strid": "b4550601-3d4c-49b5-89bf-188e2448f6f2", + "image_id": 207101, + "image_name": "6962.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 391.702, + 561.669, + 49.43599999999998, + 13.827999999999975 + ], + "priority": 11, + "parents": [ + 169004 + ], + "children": [ + 168997, + 169002, + 169003 + ], + "area": 220006.870638, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 169002, + "strid": "ffe1b749-3010-4d9a-a960-7ff46acd7844", + "image_id": 207101, + "image_name": "6962.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 52.923, + 575.674, + 409.92, + 319.278 + ], + "priority": 12, + "parents": [ + 168993 + ], + "children": [ + 168999 + ], + "area": 30466.395102, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 168999, + "strid": "58b81d5f-83ff-45a4-9d89-42775f64778c", + "image_id": 207101, + "image_name": "6962.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 49.941, + 895.508, + 366.668, + 23.474000000000046 + ], + "priority": 13, + "parents": [ + 169002 + ], + "children": [], + "area": 44722.565028000005, + "iscrowd": 0, + "segmentation": [], + "text": "So a a eas es ena creneieaioetoren ota a a" + }, + { + "id": 169003, + "strid": "0a54be01-ae3d-4559-a4b0-be87ea296fca", + "image_id": 207101, + "image_name": "6962.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 470.96, + 576.35, + 240.13500000000005, + 167.08000000000004 + ], + "priority": 14, + "parents": [ + 168993 + ], + "children": [ + 169000 + ], + "area": 271437.796, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 169000, + "strid": "d4c805c6-b8d5-4589-b92e-e37cc35f43ad", + "image_id": 207101, + "image_name": "6962.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 476.049, + 757.457, + 179.67899999999997, + 18.840000000000032 + ], + "priority": 15, + "parents": [ + 169003 + ], + "children": [], + "area": 360586.64739299996, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 168997, + "strid": "4940b5c8-04c5-4a57-9764-bd0d3845ff18", + "image_id": 207101, + "image_name": "6962.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 14.257, + 927.869, + 799.555, + 189.485 + ], + "priority": 16, + "parents": [ + 168993 + ], + "children": [], + "area": 13228.628333, + "iscrowd": 0, + "segmentation": [], + "text": "The findings showed a main role of limbic (extra-nuclear gyrus) and primary somatosensory (angular gyrus) brain areas\nin response to the gaze interaction [Table 1]. Moreover the woman who avoids the infant while the infant looks at her\nproduces an spontaneous and early alert response probably due to the un-responsiveness of the caregiver toward the\ninfant. In response to the convergence gaze [Table 2], was found a negative association between the confidence attachment\ndimension and the intensities of the temporal and limbic areas, which seems to be an early spontaneous and emotional\nresponse to the intimacy; moreover was found a positive association between the relationships as secondary attachment\ndimension and the intensities of the frontal and parietal areas, which seems to be a more controlled and defensive\nresponse to the intimacy. These two dimensions of attachment style, confidence and relationships as secondary, are related\nto the avoidant attachment style. These findings suggest that the avoidant attachment style could be the expression of both\nan early and emotional lack of confidence and a more late and rational defensive mechanism and suggest the important\nrole of the avoidant attachment style dimensions in the gaze interaction processing." + }, + { + "id": 56572, + "strid": "c3bf733e-13c7-4ae8-bba5-f240e7315fac", + "image_id": 202729, + "image_name": "119153.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 68.99, + 152.17, + 268.19, + 281.6 + ], + "priority": -1, + "parents": [], + "children": [ + 56550, + 56557, + 56548, + 56549, + 56552, + 56551 + ], + "area": 10498.208299999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 56548, + "strid": "10ee44b3-97be-40a1-896d-5b1fad30ef4b", + "image_id": 202729, + "image_name": "119153.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 493.742, + 189.668, + 2553.562, + 277.989 + ], + "priority": 1, + "parents": [ + 56572 + ], + "children": [], + "area": 93647.057656, + "iscrowd": 0, + "segmentation": [], + "text": "SITE OF EXTRAPULMONARY TUBERCULOSIS IN\nPEOPLE LIVING WITH HIV/AIDS" + }, + { + "id": 56549, + "strid": "c09689e0-43a4-4497-b4b0-cd9ce76f3e6a", + "image_id": 202729, + "image_name": "119153.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 108.534, + 544.263, + 3281.434, + 419.2869999999999 + ], + "priority": 2, + "parents": [ + 56572 + ], + "children": [], + "area": 59071.040442000005, + "iscrowd": 0, + "segmentation": [], + "text": "Gonul SENGOZ!, Filiz PEHLIVANOGLU?, Ahmet SENGOZ?,\nMeyha SAHIN?, Berna DEMIROK?, Sinem AKKAYA?\n\n‘Haseki Training and Research Hospital, Infectious Diseases and Clinical Microbiology, Istanbul/TR\n*Yenibosna Safa Hospital, Neurosurgeology, Istanbul/TR" + }, + { + "id": 56550, + "strid": "5a93e610-de53-43fc-8694-74be6a70c4ed", + "image_id": 202729, + "image_name": "119153.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 180.107, + 1057.75, + 272.3190000000001, + 53.69399999999996 + ], + "priority": 3, + "parents": [ + 56572 + ], + "children": [ + 56553 + ], + "area": 190508.17925, + "iscrowd": 0, + "segmentation": [], + "text": "Background" + }, + { + "id": 56553, + "strid": "4beccaf9-67d0-408d-9867-a85bcc450676", + "image_id": 202729, + "image_name": "119153.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 175.881, + 1137.975, + 3199.78, + 186.84799999999996 + ], + "priority": 4, + "parents": [ + 56550 + ], + "children": [], + "area": 200148.180975, + "iscrowd": 0, + "segmentation": [], + "text": "Extrapulmonary tuberculosis (EPTB) has increased relative to cases of pulmonary tuberculosis. Patients with central nervous system\n(CNS)/meningeal and disseminated EPTB and those with human immunodeficiency virus (HIV)/AIDS have increased mortality. The purpose of\nour study was to determine risk factors associated with particular types of EPTB." + }, + { + "id": 56551, + "strid": "0d473f4f-df73-4180-9fef-de13cc0bfec2", + "image_id": 202729, + "image_name": "119153.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 178.805, + 1351.307, + 490.945, + 44.72399999999993 + ], + "priority": 5, + "parents": [ + 56572 + ], + "children": [ + 56554 + ], + "area": 241620.448135, + "iscrowd": 0, + "segmentation": [], + "text": "Methods & Materials" + }, + { + "id": 56554, + "strid": "ddc665e4-2501-46d1-9450-0a299a57a925", + "image_id": 202729, + "image_name": "119153.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 175.558, + 1430.212, + 3199.414, + 121.39899999999989 + ], + "priority": 6, + "parents": [ + 56551 + ], + "children": [], + "area": 251085.15829599998, + "iscrowd": 0, + "segmentation": [], + "text": "We retrospectively reviewed cases of EPTB from 2000-2013 at a single teaching hospital. Medical records were reviewed to determine site of\nEPTB and patient demographic and clinical characteristics." + }, + { + "id": 56552, + "strid": "d4722837-4097-49d5-9ad5-db49a01c3b52", + "image_id": 202729, + "image_name": "119153.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 178.434, + 1632.763, + 166.975, + 45.64200000000005 + ], + "priority": 7, + "parents": [ + 56572 + ], + "children": [ + 56566, + 56570, + 56568, + 56555, + 56571, + 56569, + 56565, + 56567 + ], + "area": 291340.433142, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 56555, + "strid": "3573bc9c-d6d3-4be9-87d4-203ca5a4b1f6", + "image_id": 202729, + "image_name": "119153.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 174.447, + 1714.727, + 3199.471, + 453.77099999999996 + ], + "priority": 8, + "parents": [ + 56552 + ], + "children": [], + "area": 299128.980969, + "iscrowd": 0, + "segmentation": [], + "text": "Twenty-nine attacks were found in 25 patients. Most of the patients were male (22/3). Mean age was found 40. The localizations of EPTB\nwere encountered extra-thoracic lymphadenitis (5 cases), pleuritis (2 cases), meningitis (14 cases), bone joint TB (1 case), disseminated TB (1\ncase) (Fig 1,2,3: spinal tuberculoma, CNS tuberculoma and pleura TB in a case with IRIS) and GIS TB (6 cases). Mean CD+T lymphocyte counts\nof the patients at diagnosis was calculated 90 (9-633). Pulmonary TB was concurrently detected in 14 of these patients. The number of the\npatients diagnosed HIV/AIDS due to presence of EPTB was 14. CNS TB was the most commonly found localization in the cases. Mortality rate\nwas 25% when the patients were primarily diagnosed. Half of the exitus patients were CNS TB. EPTB is important for also its sequelae since it\ncaused mortality in one-fourth of the patients." + }, + { + "id": 56565, + "strid": "13d73dff-27fe-4309-9e56-c41302241448", + "image_id": 202729, + "image_name": "119153.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 182.232, + 2330.723, + 1106.412, + 481.1869999999999 + ], + "priority": 9, + "parents": [ + 56552 + ], + "children": [ + 56558 + ], + "area": 424732.313736, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 56558, + "strid": "5c9a23c3-ec39-4c05-a7fe-480397aa9a5c", + "image_id": 202729, + "image_name": "119153.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 193.441, + 2231.277, + 691.377, + 55.128000000000156 + ], + "priority": 10, + "parents": [ + 56565 + ], + "children": [], + "area": 431620.454157, + "iscrowd": 0, + "segmentation": [], + "text": "Graphic 1. Gender distribution" + }, + { + "id": 56571, + "strid": "14573150-db81-4680-9c5a-441763546542", + "image_id": 202729, + "image_name": "119153.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 185.403, + 2985.891, + 1102.366, + 457.93200000000024 + ], + "priority": 11, + "parents": [ + 56552 + ], + "children": [ + 56560 + ], + "area": 553593.149073, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 56560, + "strid": "f4eb8722-f31c-48e2-85bf-6df70d837b0b", + "image_id": 202729, + "image_name": "119153.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 196.649, + 2892.89, + 563.137, + 54.521000000000186 + ], + "priority": 12, + "parents": [ + 56571 + ], + "children": [], + "area": 568883.92561, + "iscrowd": 0, + "segmentation": [], + "text": "Graphic 3. Mortality rate" + }, + { + "id": 56566, + "strid": "95612477-41da-49db-bd07-250623fdced8", + "image_id": 202729, + "image_name": "119153.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1750.558, + 2330.072, + 1594.0190000000002, + 789.0740000000001 + ], + "priority": 13, + "parents": [ + 56552 + ], + "children": [ + 56559 + ], + "area": 4078926.180176, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 56559, + "strid": "db743c3f-e5c2-4cb3-a07a-d04c3d76b1a2", + "image_id": 202729, + "image_name": "119153.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1739.535, + 2231.017, + 1459.3479999999997, + 56.27599999999984 + ], + "priority": 14, + "parents": [ + 56566 + ], + "children": [], + "area": 3880932.1570949997, + "iscrowd": 0, + "segmentation": [], + "text": "Graphic 2. The distribution of extrapulmonary tuberculosis cases" + }, + { + "id": 56570, + "strid": "36daa616-90b6-483b-8c75-edd9410b5d95", + "image_id": 202729, + "image_name": "119153.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 165.703, + 3535.603, + 626.87, + 464.06100000000015 + ], + "priority": 15, + "parents": [ + 56552 + ], + "children": [ + 56561 + ], + "area": 585860.023909, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 56561, + "strid": "0341e49e-4dbb-43af-a543-d8263ffb1c13", + "image_id": 202729, + "image_name": "119153.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 194.065, + 4070.664, + 518.6099999999999, + 112.02299999999968 + ], + "priority": 16, + "parents": [ + 56570 + ], + "children": [], + "area": 789973.40916, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. Pleura TBina\ncase with IRIS" + }, + { + "id": 56569, + "strid": "0cefb74e-bab0-46fc-a152-687aea444851", + "image_id": 202729, + "image_name": "119153.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 955.93, + 3525.042, + 512.7499999999999, + 478.53999999999996 + ], + "priority": 17, + "parents": [ + 56552 + ], + "children": [ + 56562 + ], + "area": 3369693.3990599997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 56562, + "strid": "bfd6218f-e1b1-451b-9df5-c75d7a282fe3", + "image_id": 202729, + "image_name": "119153.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 947.261, + 4073.137, + 603.0799999999999, + 53.659000000000106 + ], + "priority": 18, + "parents": [ + 56569 + ], + "children": [], + "area": 3858323.827757, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2. CNS tuberculoma" + }, + { + "id": 56568, + "strid": "e1c96e53-98a6-447c-9cf1-7198460e740b", + "image_id": 202729, + "image_name": "119153.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1638.884, + 3447.513, + 430.942, + 574.5720000000001 + ], + "priority": 19, + "parents": [ + 56552 + ], + "children": [ + 56563 + ], + "area": 5650073.895492, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 56563, + "strid": "bc6ec88b-193f-4792-b60c-75e4deda954b", + "image_id": 202729, + "image_name": "119153.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1670.946, + 4073.339, + 348.52600000000007, + 112.6289999999999 + ], + "priority": 20, + "parents": [ + 56568 + ], + "children": [], + "area": 6806329.508694, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3. Spinal\ntuberculoma" + }, + { + "id": 56567, + "strid": "31da1e7d-c00a-451a-a16b-3326cb1ee030", + "image_id": 202729, + "image_name": "119153.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2289.03, + 3243.672, + 1030.3889999999997, + 776.0830000000001 + ], + "priority": 21, + "parents": [ + 56552 + ], + "children": [ + 56564 + ], + "area": 7424862.51816, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 56564, + "strid": "82958911-91a4-45ba-b431-d54acbb156fb", + "image_id": 202729, + "image_name": "119153.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2297.391, + 4074.77, + 1070.3430000000003, + 256.2720000000004 + ], + "priority": 22, + "parents": [ + 56567 + ], + "children": [], + "area": 9361339.92507, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 4. TB therapy in patients with meningitis\nfirst, second, fourth, fifth, and seventh months.\ntuberculoma in the progression and regression\nof coronary sections of a contrast T1W" + }, + { + "id": 56557, + "strid": "a415032c-a03d-46cc-a9e7-5daea30e5982", + "image_id": 202729, + "image_name": "119153.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 176.552, + 4307.651, + 251.73500000000004, + 44.922999999999774 + ], + "priority": 23, + "parents": [ + 56572 + ], + "children": [ + 56556 + ], + "area": 760524.399352, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion" + }, + { + "id": 56556, + "strid": "a05f04db-7a25-429d-8f21-7eeffff58078", + "image_id": 202729, + "image_name": "119153.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 171.202, + 4388.317, + 3203.276, + 255.04899999999998 + ], + "priority": 24, + "parents": [ + 56557 + ], + "children": [], + "area": 751288.647034, + "iscrowd": 0, + "segmentation": [], + "text": "Among patients with EPTB coinfected with HIV low CD4 counts were more likely to have CNS/meningeal and disseminated disease. Care for\nsimilar patients should include con- sideration of these forms of EPTB since they carry a high risk of death. The results of this study provide\ninformation regarding the various forms of EPTB in HlV-infected persons. Early diagnosis of tuberculosis and prompt institution of\nantitubercular treatment (ATT) reduces mortality and morbidity significantly." + }, + { + "id": 126471, + "strid": "fb01b64c-8a39-4ae6-8b9d-371a0c6af95e", + "image_id": 205426, + "image_name": "15113.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 177.91, + 382.58, + 431.93000000000006, + 130.40000000000003 + ], + "priority": -1, + "parents": [], + "children": [ + 126446, + 126457, + 126463, + 126468, + 126450, + 126449, + 126454, + 126460, + 126465, + 126467, + 126452, + 126462, + 126445 + ], + "area": 68064.8078, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 126445, + "strid": "ea1cca88-f2ee-4fb4-8206-d9e76e6f9c7d", + "image_id": 205426, + "image_name": "15113.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 8.825, + 62.758, + 3274.946, + 203.75699999999998 + ], + "priority": 1, + "parents": [ + 126471 + ], + "children": [], + "area": 553.83935, + "iscrowd": 0, + "segmentation": [], + "text": "pysradb: A Python package to query next-generation sequencing metadata and\ndata from NCBI Sequence Read Archive\n\nSeed we ToNo™" + }, + { + "id": 126467, + "strid": "fa30dc78-b113-4e26-b701-f7c1d3de97de", + "image_id": 205426, + "image_name": "15113.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1395.08, + 281.189, + 514.471, + 161.92199999999997 + ], + "priority": 2, + "parents": [ + 126471 + ], + "children": [], + "area": 392281.15012, + "iscrowd": 0, + "segmentation": [], + "text": "Saket Choudhary\n\nskchoudh@usc.edu\nUniversity of Southern California" + }, + { + "id": 126446, + "strid": "63fba29e-0978-4852-828f-5c53cccbf7ca", + "image_id": 205426, + "image_name": "15113.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 731.598, + 551.208, + 244.75800000000004, + 36.88099999999997 + ], + "priority": 3, + "parents": [ + 126471 + ], + "children": [ + 126448, + 126447 + ], + "area": 403262.67038399994, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 126447, + "strid": "f05a3a75-1f83-4840-846a-170c7a4e8f9a", + "image_id": 205426, + "image_name": "15113.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 107.397, + 628.121, + 1500.439, + 249.57499999999993 + ], + "priority": 4, + "parents": [ + 126446 + ], + "children": [], + "area": 67458.311037, + "iscrowd": 0, + "segmentation": [], + "text": "The NCBI Sequence Read Archive (SRA) is the primary archive of next-generation sequencing datasets.\nSRA makes metadata and raw sequencing data available to the research community to encourage re-\nproducibility and to provide avenues for testing novel hypotheses on publicly available data. However,\nmethods to programmatically access this data are limited. We introduce the Python package, pysradb,\nwhich provides a collection of command line methods to query and download metadata and data from\nSRA, utilizing the curated metadata database available through the SRAdb project." + }, + { + "id": 126448, + "strid": "5fd4c1b4-63ab-432f-b69d-1cda78d93a2a", + "image_id": 205426, + "image_name": "15113.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 102.375, + 903.835, + 1500.443, + 887.4099999999999 + ], + "priority": 5, + "parents": [ + 126446 + ], + "children": [], + "area": 92530.108125, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 126449, + "strid": "48b64e48-bc44-4b78-b64e-6a286c3481e2", + "image_id": 205426, + "image_name": "15113.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 708.986, + 1852.408, + 290.34000000000003, + 43.72600000000011 + ], + "priority": 6, + "parents": [ + 126471 + ], + "children": [ + 126470 + ], + "area": 1313331.3382879999, + "iscrowd": 0, + "segmentation": [], + "text": "Searching SRA" + }, + { + "id": 126470, + "strid": "2993ba03-162f-490b-bd4d-070a6b9be5eb", + "image_id": 205426, + "image_name": "15113.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 256.746, + 1931.976, + 1192.754, + 446.7739999999999 + ], + "priority": 7, + "parents": [ + 126449 + ], + "children": [], + "area": 496027.110096, + "iscrowd": 0, + "segmentation": [], + "text": "$ pysradb search '\"ribosome profiling\"' | head\n\nstudy_accession experiment_accession sample_accession run_accession\n\nDRP003075 DRX019536 DRS026974 DRRO21383\nDRP003075 DRX019537 DRS026982 DRRO21384\nDRP003075 DRX019538 DRS026979 DRRO21385\nDRP003075 DRX019540 DRS026984 DRRO21387\nDRP003075 DRX019541 DRS026978 DRRO21388\nDRP003075 DRX019543 DRS026980 DRRO21390\nDRP003075 DRX019544 DRS026981 DRRO21391\n\nERPO13565 ERX1264364 ERS1016056 ERR1190989" + }, + { + "id": 126450, + "strid": "3c26a923-f3fc-4b57-bfc0-0f5d6947bdcf", + "image_id": 205426, + "image_name": "15113.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 585.034, + 2442.874, + 539.006, + 48.18600000000015 + ], + "priority": 8, + "parents": [ + 126471 + ], + "children": [ + 126451 + ], + "area": 1429164.347716, + "iscrowd": 0, + "segmentation": [], + "text": "Getting detailed metadata" + }, + { + "id": 126451, + "strid": "797f7a30-913b-4a82-81a7-9d8535e50513", + "image_id": 205426, + "image_name": "15113.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 102.563, + 2559.919, + 1502.352, + 1007.0520000000001 + ], + "priority": 9, + "parents": [ + 126450 + ], + "children": [], + "area": 262552.972397, + "iscrowd": 0, + "segmentation": [], + "text": "$ pysradb metadata SRP010679 --desc --expand\n\n[truncated]\nrun_accession\nSRR403882\nSRR403883\nSRR403884\nSRR403885\nSRR403886\nSRR403887\nSRR403888\nSRR403889\nSRR403890\n\ncell_line sample_type treatment\npe3 polya rna vehicle\npe3 ribosome protected rna vehicle\npe3 polya rna rapamycin\npe3 ribosome protected rna rapamycin\npc3 polya rna pp242\n\npe3 ribosome protected rna pp242\n\npe3 polya rna vehicle\npe3 ribosome protected rna vehicle\npe3 polya rna rapamycin\n\nAny SRA project might consist of experiments involving multiple assay types. The assay associated with\nany project can be obtained by providing --assay flag:\n\n$ pysradb metadata SRP000941 --assay | tr -s '' ' | cut -f5 -d'' '' | tail -n +2 |\n\nsort | uniq -c\n\n999 Bisulfite-Seq\n768 ChIP-Seq\n\n121 OTHER\n\n353 RNA-Seq\n\n28 WGS" + }, + { + "id": 126452, + "strid": "ed2de003-6d4f-4cf8-8f20-fccaf4d2b23e", + "image_id": 205426, + "image_name": "15113.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 622.256, + 3657.896, + 460.8960000000001, + 46.40599999999995 + ], + "priority": 10, + "parents": [ + 126471 + ], + "children": [ + 126453 + ], + "area": 2276147.733376, + "iscrowd": 0, + "segmentation": [], + "text": "Getting SRPs from GSE" + }, + { + "id": 126453, + "strid": "d8b7cf2b-f8ff-474d-93d7-ec3e7877a03a", + "image_id": 205426, + "image_name": "15113.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 104.802, + 3736.474, + 1498.554, + 839.2619999999997 + ], + "priority": 11, + "parents": [ + 126452 + ], + "children": [], + "area": 391589.94814800005, + "iscrowd": 0, + "segmentation": [], + "text": "GEO assigns a dataset accession (accession prefix 'GSE') that is linked to the corresponding accession\non the SRA (accession prefix 'SRP’). It is often necessary to interpolate between the two accessions.\ngse-to-srp sub-command allows converting GSE to SRP:\n\n$ pysradb gse-to-srp GSE24355 GSE25842\n\nstudy_alias study_accession\nGSE24355 SRP003870\nGSE25842 SRP005378\n\nIt can be further expanded to obtain the corresponding experiment and run accessions:\n$ pysradb gse-to-srp --detailed --expand GSE100007\n\nstudy_accession experiment_accession sample_accession experiment_alias\n\nSRP109126 SRX2916198 SRS2282390 GSM2667747\nSRP109126 SRX2916199 SRS2282391 GSM2667748\nSRP109126 SRX2916200 SRS2282392 GSM2667749\nSRP109126 SRX2916201 SRS2282393 GSM2667750\nSRP109126 SRX2916202 SRS2282394 GSM2667751\n\nSRP109126 SRX2916203 SRS2282395 GSM2667752" + }, + { + "id": 126463, + "strid": "44aad2d2-3620-4943-830d-c9ba2045b58e", + "image_id": 205426, + "image_name": "15113.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1967.262, + 549.163, + 973.2760000000001, + 48.028999999999996 + ], + "priority": 12, + "parents": [ + 126471 + ], + "children": [ + 126464 + ], + "area": 1080347.501706, + "iscrowd": 0, + "segmentation": [], + "text": "Getting a list of GEO experiments for a GEO study" + }, + { + "id": 126464, + "strid": "cfef84d4-b6e4-42c1-b8c9-495853037682", + "image_id": 205426, + "image_name": "15113.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1701.46, + 625.977, + 1501.326, + 487.03200000000004 + ], + "priority": 13, + "parents": [ + 126463 + ], + "children": [], + "area": 1065074.82642, + "iscrowd": 0, + "segmentation": [], + "text": "Any GEO study (accession prefix 'GSE’) will involve a collection of experiments (accession prefix 'GSM').\nWe can obtain an entire list of experiments corresponding to the study using the gse-to-gsm sub-\ncommand from pysradb. To obtain more structured metadata, we can use additional flags '--expand’\n\n'--desc':\n\n$ pysradb gse-to-gsm --desc --expand GSE41637 | head\n\nstudy_alias experiment_alias source_name\n\nGSE41637\nGSE41637\nGSE41637\nGSE41637\n\nGSM1020640_1\nGSM1020641_1\nGSM1020642_1\nGSM1020643_1\n\nmouse_brain\nmouse_colon\nmouse_heart\n\nstrain tissue\ndba/2j brain\ndba/2j colon\ndba/2j heart\n\nmouse_kidney dba/2j kidney" + }, + { + "id": 126465, + "strid": "cefe4627-24ca-4fb1-9f5d-6f86efba768a", + "image_id": 205426, + "image_name": "15113.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2223.405, + 1194.803, + 456.94900000000007, + 50.673 + ], + "priority": 14, + "parents": [ + 126471 + ], + "children": [ + 126466 + ], + "area": 2656530.9642150006, + "iscrowd": 0, + "segmentation": [], + "text": "Getting SRX from GSM" + }, + { + "id": 126466, + "strid": "10850a32-ed22-458f-8a32-7ca6bb3f503a", + "image_id": 205426, + "image_name": "15113.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1703.504, + 1293.113, + 1496.8609999999999, + 316.28600000000006 + ], + "priority": 15, + "parents": [ + 126465 + ], + "children": [], + "area": 2202823.167952, + "iscrowd": 0, + "segmentation": [], + "text": "gsm-to-srx allows conversion from GEO experiments (accession prefix 'GSM') to SRA experiments (ac-\ncession prefix 'SRX’):\n\n$ pysradb gsm-to-srx GSM1020640 GSM1020646\n\nexperiment_alias experiment_accession\nGSM1020640_1 SRX196264\nGSM1020646_1 SRX196270" + }, + { + "id": 126462, + "strid": "19814860-1ed2-4a23-9754-d1f3e34874d4", + "image_id": 205426, + "image_name": "15113.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2225.666, + 1689.748, + 448.68100000000004, + 57.222999999999956 + ], + "priority": 16, + "parents": [ + 126471 + ], + "children": [ + 126461 + ], + "area": 3760814.6721680006, + "iscrowd": 0, + "segmentation": [], + "text": "Getting SRR from GSM" + }, + { + "id": 126461, + "strid": "5579bf6e-5364-43ff-b3bb-e364fdf4ed77", + "image_id": 205426, + "image_name": "15113.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1704.178, + 1794.351, + 1494.506, + 309.76200000000017 + ], + "priority": 17, + "parents": [ + 126462 + ], + "children": [], + "area": 3057893.4984780005, + "iscrowd": 0, + "segmentation": [], + "text": "gsm-to-srr allows conversion from GEO experiments (accession prefix 'GSM') to SRA runs (accession\nprefix 'SRR’):\n\n$ pysradb gsm-to-srr GSM1020640 GSM1020646\n\nexperiment_alias run_accession\nGSM1020640_1 SRR594393\nGSM1020646_1 SRR594399" + }, + { + "id": 126460, + "strid": "67283920-3aaf-4b36-b358-25717637a2ab", + "image_id": 205426, + "image_name": "15113.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2004.808, + 2191.654, + 889.7150000000001, + 51.60500000000002 + ], + "priority": 18, + "parents": [ + 126471 + ], + "children": [ + 126459, + 126458 + ], + "area": 4393845.472432, + "iscrowd": 0, + "segmentation": [], + "text": "Seemlessly downloading entire SRA projects" + }, + { + "id": 126459, + "strid": "550a9214-e1e2-4590-ab71-a912cb768ab6", + "image_id": 205426, + "image_name": "15113.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1704.25, + 2291.564, + 1502.232, + 160.94799999999987 + ], + "priority": 19, + "parents": [ + 126460 + ], + "children": [], + "area": 3905397.9469999997, + "iscrowd": 0, + "segmentation": [], + "text": "pysradb enables seemless downloads from SRA. It organizes the downloaded data following the NCBI\nhiererachy: 'SRP => SRX => SRR' of storing data. Each 'SRP' (project) has multiple 'SRX' (experiments)\n\nand each 'SRX' in turn has multiple 'SRR' (runs). Multiple projects can be downloaded at once using the\ndownload sub-command:" + }, + { + "id": 126458, + "strid": "977cca8a-03c6-43e5-b3a7-6dea06ad2a0c", + "image_id": 205426, + "image_name": "15113.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2076.453, + 2487.816, + 774.6460000000002, + 466.22199999999975 + ], + "priority": 20, + "parents": [ + 126460 + ], + "children": [], + "area": 5165832.996648, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 126457, + "strid": "6878c2e5-bac1-4d9a-b982-5bb933012ded", + "image_id": 205426, + "image_name": "15113.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2225.491, + 3002.644, + 455.2289999999998, + 51.19599999999991 + ], + "priority": 21, + "parents": [ + 126471 + ], + "children": [ + 126456 + ], + "area": 6682357.198204, + "iscrowd": 0, + "segmentation": [], + "text": "Support for Unix pipes" + }, + { + "id": 126456, + "strid": "4de50859-c29a-474f-9eed-f495924f5f58", + "image_id": 205426, + "image_name": "15113.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1695.863, + 3091.323, + 1513.4309999999998, + 240.9050000000002 + ], + "priority": 22, + "parents": [ + 126457 + ], + "children": [], + "area": 5242460.2967489995, + "iscrowd": 0, + "segmentation": [], + "text": "download also allows Unix pipes-based inputs. Consider a SRA project that has different assays. How-\never, we want to be able to download only 'RNA-seq' samples. We can do this by subsetting the metadata\noutput for only 'RNA-seq' samples:\n\n$ pysradb metadata SRP000941 --assay | grep 'study|RNA-Seq' | pysradb download\nThis will only download the 'RNA-seq' samples from the project." + }, + { + "id": 126454, + "strid": "d41acaa9-2ae8-4dfb-b946-2943e716598f", + "image_id": 205426, + "image_name": "15113.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2251.225, + 4199.532, + 399.8879999999999, + 45.23899999999958 + ], + "priority": 23, + "parents": [ + 126471 + ], + "children": [ + 126455 + ], + "area": 9454091.4267, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements" + }, + { + "id": 126455, + "strid": "a849baaa-d489-4040-9c74-898140cbbf5c", + "image_id": 205426, + "image_name": "15113.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1717.716, + 4271.628, + 1468.833, + 94.0630000000001 + ], + "priority": 24, + "parents": [ + 126454 + ], + "children": [], + "area": 7337443.761647999, + "iscrowd": 0, + "segmentation": [], + "text": "We acknowledge travel support made possible by Fellowships from Open Bioinformatics Foundation\nand ISCB (Akamai)." + }, + { + "id": 126468, + "strid": "23cf7c98-5f91-439b-9154-69abeeb23092", + "image_id": 205426, + "image_name": "15113.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2337.897, + 3813.314, + 228.3510000000001, + 39.43299999999999 + ], + "priority": 25, + "parents": [ + 126471 + ], + "children": [ + 126469 + ], + "area": 8915135.360658, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 126469, + "strid": "76fd05b9-9466-451d-837f-3b4ae83c9240", + "image_id": 205426, + "image_name": "15113.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1698.009, + 3917.182, + 1494.482, + 211.46299999999974 + ], + "priority": 26, + "parents": [ + 126468 + ], + "children": [], + "area": 6651410.290638, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 45591, + "strid": "b6a5d97a-154b-40e9-8966-af40e55f6877", + "image_id": 202282, + "image_name": "118473.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 685.06, + 157.3, + 170.0100000000001, + 236.53999999999996 + ], + "priority": -1, + "parents": [], + "children": [ + 45570, + 45561, + 45528, + 45530, + 45568, + 45543, + 45572, + 45560, + 45562, + 45529, + 45586, + 45548, + 45527 + ], + "area": 107759.938, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 45527, + "strid": "db6110ff-5333-47d8-b041-4b6ffb18cd1a", + "image_id": 202282, + "image_name": "118473.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 1065.761, + 106.726, + 2990.595, + 247.264 + ], + "priority": 1, + "parents": [ + 45591 + ], + "children": [], + "area": 113744.408486, + "iscrowd": 0, + "segmentation": [], + "text": "Evolution and Controllability of Cancer Networks:\na Bo@lean Perspective" + }, + { + "id": 45528, + "strid": "d57c0301-2db2-4a68-a08e-f92f04811615", + "image_id": 202282, + "image_name": "118473.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1515.949, + 373.144, + 2011.7649999999999, + 124.61900000000003 + ], + "priority": 2, + "parents": [ + 45591 + ], + "children": [], + "area": 565667.273656, + "iscrowd": 0, + "segmentation": [], + "text": "Sriganesh Srihari and Mark A. Ragan\n\nInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia" + }, + { + "id": 45529, + "strid": "abebe28f-5720-4e97-b871-39f5cae09512", + "image_id": 202282, + "image_name": "118473.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 293.644, + 627.362, + 654.494, + 130.24799999999993 + ], + "priority": 3, + "parents": [ + 45591 + ], + "children": [ + 45539, + 45532, + 45533, + 45538, + 45537, + 45531 + ], + "area": 184221.08712799998, + "iscrowd": 0, + "segmentation": [], + "text": "1. Introduction\n\nControllability of a Dynamical System" + }, + { + "id": 45531, + "strid": "5214876b-101f-4b5f-b919-3c88e2487d67", + "image_id": 202282, + "image_name": "118473.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 124.274, + 787.241, + 1008.0190000000001, + 144.28099999999995 + ], + "priority": 4, + "parents": [ + 45529 + ], + "children": [], + "area": 97833.588034, + "iscrowd": 0, + "segmentation": [], + "text": "A dynamical system is controllable if it can be driven from an initial\nstate to any desired final state within finite time by applying a\nsuitable choice of inputs." + }, + { + "id": 45537, + "strid": "825236f3-7a17-4612-a8df-fcd3fab0d93d", + "image_id": 202282, + "image_name": "118473.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 172.866, + 937.014, + 949.1960000000001, + 86.68399999999997 + ], + "priority": 5, + "parents": [ + 45529 + ], + "children": [], + "area": 161977.862124, + "iscrowd": 0, + "segmentation": [] + }, + 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"To control the network, we first need to identify the set of nodes\nthat, if driven by different signals, can offer full control over the\nnetwork. This allows structural controllability of the network." + }, + { + "id": 45545, + "strid": "eb053547-9fc7-4327-9430-570562b8d34f", + "image_id": 202282, + "image_name": "118473.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 120.525, + 2433.932, + 861.686, + 44.373999999999796 + ], + "priority": 15, + "parents": [ + 45543 + ], + "children": [], + "area": 293349.6543, + "iscrowd": 0, + "segmentation": [], + "text": "Kallman’s controllability rank criterion (Kallman, 1963)" + }, + { + "id": 45546, + "strid": "6239dcad-5170-4166-aae4-49bfa5a3f66c", + "image_id": 202282, + "image_name": "118473.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 124.653, + 2481.403, + 997.904, + 91.84400000000005 + ], + "priority": 16, + "parents": [ + 45543 + ], + "children": [], + "area": 309314.32815899997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 45547, + "strid": "0dc9a251-9a23-4611-97d1-b792d4a1f9fd", + "image_id": 202282, + "image_name": "118473.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 179.347, + 2575.311, + 895.74, + 151.69799999999987 + ], + "priority": 17, + "parents": [ + 45543 + ], + "children": [], + "area": 461874.30191700003, + "iscrowd": 0, + "segmentation": [], + "text": "C = (B, AB, A7B,...,A’ 1B)\nhas the full rank, that is,\nrank (C) =N." + }, + { + "id": 45548, + "strid": "ded73aba-1baf-4710-8412-785e0058cef9", + "image_id": 202282, + "image_name": "118473.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 320.725, + 2756.936, + 630.527, + 104.22800000000007 + ], + "priority": 18, + "parents": [ + 45591 + ], + "children": [ + 45549 + ], + "area": 884218.2986000001, + "iscrowd": 0, + "segmentation": [], + "text": "Controllability of Complex Networks\n(Barabasi et al., 2011)" + }, + { + "id": 45549, + "strid": "9cac0d40-b239-4d85-bbca-4a85af29043f", + "image_id": 202282, + "image_name": "118473.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 126.717, + 2866.323, + 981.3930000000001, + 629.4949999999999 + ], + "priority": 19, + "parents": [ + 45548 + ], + "children": [], + "area": 363211.851591, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 45530, + "strid": "4cd016b2-87cc-4fa3-b1c5-e02b92ce06b9", + "image_id": 202282, + "image_name": "118473.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1504.03, + 631.261, + 597.952, + 124.33400000000006 + ], + "priority": 20, + "parents": [ + 45591 + ], + "children": [ + 45534, + 45536, + 45535 + ], + "area": 949435.48183, + "iscrowd": 0, + "segmentation": [], + "text": "2a. 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Mutation in KRAS\noncogene and TP53, CDKN2A,,\nSMAD4 tumor suppressors.\n\nBRCA1 tumors predominantly\ntriple-negative or basal-like.\nMutation in BRCA1. Highly\naggressive.\n\nBRCA2 tumors predominantly\nluminal. Mutation in BRCA2.\nLess aggressive.\n\nSpinal cord injury causes\nbiochemical changes contributing\nto death of neurons, glial\nproliferation and axonal loss." + }, + { + "id": 45579, + "strid": "196df7ed-96cf-4f0f-9b7d-ac6a160362ef", + "image_id": 202282, + "image_name": "118473.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2448.151, + 2423.071, + 521.4749999999999, + 279.8620000000001 + ], + "priority": 47, + "parents": [ + 45586 + ], + "children": [], + "area": 5932043.691721, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 45578, + "strid": "14481417-e7e4-4624-be04-5382106fa0b1", + "image_id": 202282, + "image_name": "118473.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2980.821, + 2422.138, + 538.2669999999998, + 284.52599999999984 + ], + "priority": 48, + "parents": [ + 45586 + ], + "children": [], + "area": 7219959.815297999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 45577, + "strid": "7799aa9a-b541-4252-9d34-286b23e78656", + "image_id": 202282, + "image_name": "118473.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2462.144, + 2746.778, + 683.7950000000001, + 381.5450000000001 + ], + "priority": 49, + "parents": [ + 45586 + ], + "children": [], + "area": 6762962.972031998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 45576, + "strid": "88c330ab-e3ef-41de-a036-7d7a8031369b", + "image_id": 202282, + "image_name": "118473.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3172.06, + 2781.294, + 347.9609999999998, + 358.22299999999996 + ], + "priority": 50, + "parents": [ + 45586 + ], + "children": [], + "area": 8822431.44564, + "iscrowd": 0, + "segmentation": [], + "text": "Some of the flipped genes are\ndifferential expressed (p < 0.001).\n\nOthers are differentially co-expressed\nwith key genes involved in pancreatic\nand breast tumors.\n\nDifferent genes flipped at different\ntimepoints post spinal cord injury.\n\nInterestingly, several cell-cycle genes\ninvolved in spinal-cord response." + }, + { + "id": 45574, + "strid": "bc5c05de-3ffc-439e-b69e-6ec57793ad51", + "image_id": 202282, + "image_name": "118473.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2473.339, + 3183.362, + 490.6909999999998, + 296.65300000000025 + ], + "priority": 51, + "parents": [ + 45586 + ], + "children": [], + "area": 7873533.385718, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 45575, + "strid": "5f84a14d-b0b0-467f-8740-f62e3691bc77", + "image_id": 202282, + "image_name": "118473.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 3022.8, + 3186.16, + 474.8319999999999, + 291.98900000000003 + ], + "priority": 52, + "parents": [ + 45586 + ], + "children": [], + "area": 9631124.448, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 45562, + "strid": "9e75e418-46c6-4e82-95f3-db44adedf686", + "image_id": 202282, + "image_name": "118473.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3946.933, + 630.092, + 431.7529999999997, + 40.96500000000003 + ], + "priority": 53, + "parents": [ + 45591 + ], + "children": [ + 45565, + 45564, + 45563, + 45566, + 45567 + ], + "area": 2486930.907836, + "iscrowd": 0, + "segmentation": [], + "text": "4. Robusthess of Cancer" + }, + { + "id": 45563, + "strid": "8a067855-fd69-4076-9213-0c9aa6758633", + "image_id": 202282, + "image_name": "118473.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3643.059, + 704.218, + 1058.7920000000004, + 361.9619999999999 + ], + "priority": 54, + "parents": [ + 45562 + ], + "children": [], + "area": 2565507.722862, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 45565, + "strid": "b050cd29-8bad-4233-97a9-baecbdfc2615", + "image_id": 202282, + "image_name": "118473.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3654.056, + 1083.93, + 922.6250000000005, + 290.72 + ], + "priority": 55, + "parents": [ + 45562 + ], + "children": [], + "area": 3960740.92008, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 45564, + "strid": "3481770a-8ab9-45ca-864e-a34379a34a74", + "image_id": 202282, + "image_name": "118473.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3665.027, + 1392.203, + 999.4189999999999, + 379.5819999999999 + ], + "priority": 56, + "parents": [ + 45562 + ], + "children": [], + "area": 5102461.584481, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 45566, + "strid": "0c4b5bcd-893f-4506-a958-c7e24e84046a", + "image_id": 202282, + "image_name": "118473.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3710.006, + 1810.182, + 810.7249999999999, + 240.25600000000009 + ], + "priority": 57, + "parents": [ + 45562 + ], + "children": [], + "area": 6715786.081092, + "iscrowd": 0, + "segmentation": [], + "text": "“Passing of the baton” among cancer genes\n\nWe hypothesize that robustness of cancer partly\nstems from the fact that genes from different biological\nprocesses and/or cellular components are involved in\ndifferent stages (timepoints) during tumor progression." + }, + { + "id": 45567, + "strid": "a6f2d0f2-75cc-4bf7-8fab-8ec88d60e445", + "image_id": 202282, + "image_name": "118473.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3672.706, + 2076.767, + 952.2460000000001, + 92.15299999999979 + ], + "priority": 58, + "parents": [ + 45562 + ], + "children": [], + "area": 7627354.621502, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 45568, + "strid": "ff2fa2b7-dfa2-4e76-9eab-08a8a7e177c3", + "image_id": 202282, + "image_name": "118473.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3882.244, + 2202.928, + 560.596, + 46.07600000000002 + ], + "priority": 59, + "parents": [ + 45591 + ], + "children": [ + 45569 + ], + "area": 8552304.010432, + "iscrowd": 0, + "segmentation": [], + "text": "5. Conclusions and Future Werk" + }, + { + "id": 45569, + "strid": "5c51b01f-3c39-49bf-9429-ca50c13e55b6", + "image_id": 202282, + "image_name": "118473.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3655.153, + 2274.237, + 957.7310000000002, + 363.1260000000002 + ], + "priority": 60, + "parents": [ + 45568 + ], + "children": [], + "area": 8312684.193260999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 45572, + "strid": "558fd0c7-853e-4f17-9b3a-0728e812330a", + "image_id": 202282, + "image_name": "118473.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3989.756, + 3410.789, + 344.4760000000001, + 48.26999999999998 + ], + "priority": 61, + "parents": [ + 45591 + ], + "children": [ + 45573 + ], + "area": 13608215.877484001, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements" + }, + { + "id": 45573, + "strid": "66cf5eb0-77bb-4b2b-98f6-76931fc471f7", + "image_id": 202282, + "image_name": "118473.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3661.735, + 3473.321, + 882.0340000000001, + 39.49400000000014 + ], + "priority": 62, + "parents": [ + 45572 + ], + "children": [], + "area": 12718381.071935, + "iscrowd": 0, + "segmentation": [], + "text": "Australian NHMRC project grant 1028742 to Dr Peter T. Simpson and MAR." + }, + { + "id": 45570, + "strid": "9f07bde1-e37e-4156-b535-8b7d2aa19551", + "image_id": 202282, + "image_name": "118473.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4063.258, + 2669.178, + 200.76199999999972, + 40.590999999999894 + ], + "priority": 63, + "parents": [ + 45591 + ], + "children": [ + 45571 + ], + "area": 10845558.861923998, + "iscrowd": 0, + "segmentation": [], + "text": "Sey yasy ae stsy" + }, + { + "id": 45571, + "strid": "6a40d3a9-e90d-40d0-882b-d0c151d562f8", + "image_id": 202282, + "image_name": "118473.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3639.794, + 2747.069, + 1019.1660000000002, + 630.808 + ], + "priority": 64, + "parents": [ + 45570 + ], + "children": [], + "area": 9998765.263786, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 56407, + "strid": "e32e4c6d-5a9f-4539-a077-1d88e578a20a", + "image_id": 202723, + "image_name": "119145.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 63.15, + 55.49, + 63.300000000000004, + 48.02 + ], + "priority": -1, + "parents": [], + "children": [ + 56394, + 56393, + 56403, + 56399, + 56396, + 56392 + ], + "area": 3504.1935, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 56392, + "strid": "66bd8a3d-1955-4611-80cd-298b810f0473", + "image_id": 202723, + "image_name": "119145.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 161.793, + 67.424, + 501.64, + 88.68 + ], + "priority": 1, + "parents": [ + 56407 + ], + "children": [], + "area": 10908.731232000002, + "iscrowd": 0, + "segmentation": [], + "text": "Rapid Detection of ESBL-producing\nEnterobacteriaceae from Blood Cultures:\nA Prospective Study" + }, + { + "id": 56393, + "strid": "255b8258-9e23-404d-8e0d-a57381394116", + "image_id": 202723, + "image_name": "119145.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 162.549, + 157.049, + 506.746, + 47.744 + ], + "priority": 2, + "parents": [ + 56407 + ], + "children": [], + "area": 25528.157901000002, + "iscrowd": 0, + "segmentation": [], + "text": "Laurent Dortet,” Laurent Poirel,”-“ and Patrice Nordmann-“\neee erie erat hacen Fac of cece tnversy of Pay, Susann nn Mme\neT ee Oe" + }, + { + "id": 56394, + "strid": "1606dee2-560c-4cfb-beea-dd364fc0cd48", + "image_id": 202723, + "image_name": "119145.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 365.516, + 215.033, + 94.46199999999999, + 19.427999999999997 + ], + "priority": 3, + "parents": [ + 56407 + ], + "children": [ + 56395 + ], + "area": 78598.002028, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 56395, + "strid": "9bbe3044-398b-4f38-8da4-c56465922a67", + "image_id": 202723, + "image_name": "119145.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 58.683, + 239.821, + 707.458, + 32.15700000000001 + ], + "priority": 4, + "parents": [ + 56394 + ], + "children": [], + "area": 14073.415743, + "iscrowd": 0, + "segmentation": [], + "text": "Enterobacterial strains producing clavulanic-acid inhibited extended-spectrum p-lactamases (ESBLs) are increasingly reported worldwide, The rapid detection of ESBL-\nproducing Enterobactenacece responsible for bacteremia is of umast portance since thelr successful treatment depends on prompt administration of the apPropte\nvrpumicrtbeh agutts. The ESBL NEP test has been evchastedd here prospectively to detece ESOL frechucing Enterobecterintone direct from bleed cultures," + }, + { + "id": 56396, + "strid": "d6058a13-a603-4e38-a8ca-710b98fa6f82", + "image_id": 202723, + "image_name": "119145.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 377.0, + 281.453, + 72.25799999999998, + 17.226999999999975 + ], + "priority": 5, + "parents": [ + 56407 + ], + "children": [ + 56398, + 56397 + ], + "area": 106107.78099999999, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 56397, + "strid": "e53bd436-0ebb-4c7a-9774-44b06ad7234a", + "image_id": 202723, + "image_name": "119145.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 64.042, + 310.165, + 701.524, + 54.55200000000002 + ], + "priority": 6, + "parents": [ + 56396 + ], + "children": [], + "area": 19863.58693, + "iscrowd": 0, + "segmentation": [], + "text": "pletd culture specimens\n\nFrom Novenber 2012 to May 2013, 245 successive blood cultures postive for Gram negotives were\\tested. Blod culture specimens were from patients\nhospitalized in the Hesptl of Bicetre Prone). Al bled elton speciens were meuboted in BacT/ Alert system from bioMérieux we\n\nIdentification of bacterial species directly frém positive blood culture using MALDI-TOF (Vitek-MS, bioMérieux)" + }, + { + "id": 56398, + "strid": "b93b4a7f-eb1b-4919-b410-d97fdb80489c", + "image_id": 202723, + "image_name": "119145.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 63.744, + 370.394, + 680.176, + 243.846 + ], + "priority": 7, + "parents": [ + 56396 + ], + "children": [], + "area": 23610.395136, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 56399, + "strid": "927ad7c5-bc25-4cf1-8a4e-7edcc04df0b1", + "image_id": 202723, + "image_name": "119145.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 384.385, + 630.529, + 60.83699999999999, + 14.960000000000036 + ], + "priority": 8, + "parents": [ + 56407 + ], + "children": [ + 56400, + 56401, + 56402 + ], + "area": 242365.889665, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 56400, + "strid": "a8f3aad2-b1eb-4ef4-ae8c-68e7c9324e4c", + "image_id": 202723, + "image_name": "119145.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 64.478, + 683.225, + 375.533, + 306.721 + ], + "priority": 9, + "parents": [ + 56399 + ], + "children": [ + 56405 + ], + "area": 44052.98155, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 56405, + "strid": "93aba49c-b016-43bd-aa35-938ec34e7bde", + "image_id": 202723, + "image_name": "119145.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 59.625, + 661.092, + 378.87, + 19.836000000000013 + ], + "priority": 10, + "parents": [ + 56400 + ], + "children": [], + "area": 39417.6105, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1) Results of MALDI-TOF and ESBL detection directly on positive blood cultures (Day 0)\nend confirmation of the kiehtifefeon ond of the & Inctom resistence phenstype at day PETE." + }, + { + "id": 56401, + "strid": "8f45af15-1128-48dc-a0c9-6bdc9f612315", + "image_id": 202723, + "image_name": "119145.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 455.297, + 669.128, + 302.32400000000007, + 318.9789999999999 + ], + "priority": 11, + "parents": [ + 56399 + ], + "children": [ + 56406 + ], + "area": 304651.971016, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 56406, + "strid": "6ea5588d-fc36-488f-9453-9df0a36bb831", + "image_id": 202723, + "image_name": "119145.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 454.363, + 657.888, + 258.32700000000006, + 10.071000000000026 + ], + "priority": 12, + "parents": [ + 56401 + ], + "children": [], + "area": 298919.965344, + "iscrowd": 0, + "segmentation": [], + "text": "Table 2. Characterization of ESBL~producing Enterobacteriaceae" + }, + { + "id": 56402, + "strid": "4459f2ba-dc3d-47fa-a6d9-eec13cbe3a9e", + "image_id": 202723, + "image_name": "119145.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 65.31, + 991.258, + 703.866, + 35.452999999999975 + ], + "priority": 13, + "parents": [ + 56399 + ], + "children": [], + "area": 64739.059980000005, + "iscrowd": 0, + "segmentation": [], + "text": "ResylfG'vt the ESOL NOP test were 100% correlated with'thise of the double disk-diffusion mathed with theqwin advantoge that they were obtained in less\nthan 20 min cvectly from the elmcal sample versus on aditive 2¢h tine of incubetion for the double disk aifusion method. Adaiionally, the hame-made pratecel\nused for the identification of bacterial species directly from positive bloed culture is efficient for an accurate and rapid identification of Gram negative bacli." + }, + { + "id": 56403, + "strid": "6723c518-4f74-4874-9490-40cdc03438be", + "image_id": 202723, + "image_name": "119145.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 370.208, + 1034.59, + 89.815, + 16.07199999999989 + ], + "priority": 14, + "parents": [ + 56407 + ], + "children": [ + 56404 + ], + "area": 383013.49472, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 56404, + "strid": "7076ca4c-22f2-4754-89ec-2d5a47ef7718", + "image_id": 202723, + "image_name": "119145.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 70.51, + 1061.062, + 686.376, + 46.32600000000002 + ], + "priority": 15, + "parents": [ + 56403 + ], + "children": [], + "area": 74815.48161999999, + "iscrowd": 0, + "segmentation": [], + "text": "Using the CSL NDE fest, identification of an ESBL producer responsible for a bacteremia can be reduced from 24-88 hours to 20 min with\n100% sensibility, 100% specificity, 100% negative predictive value and 100% positive predictive value. Since the successful treatment of\nsepticemia depends on prompt administration of the appropriate antimicrobial agents, use of the ESBL NDP test directly from positive blood\ncultures may significantly improve the outcome of infected patients." + }, + { + "id": 182721, + "strid": "cb33663e-ef21-446f-bec3-edf5c1d2df78", + "image_id": 207631, + "image_name": "8523.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 631.3, + 10.85, + 111.25999999999999, + 58.449999999999996 + ], + "priority": -1, + "parents": [], + "children": [ + 182697, + 182696, + 182698, + 182720, + 182701, + 182700, + 182699 + ], + "area": 6849.605, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 182696, + "strid": "3271f59f-3610-4216-8738-5b1afdfce49c", + "image_id": 207631, + "image_name": "8523.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 62.874, + 85.242, + 468.81999999999994, + 59.32200000000002 + ], + "priority": 1, + "parents": [ + 182721 + ], + "children": [], + "area": 5359.505508, + "iscrowd": 0, + "segmentation": [], + "text": "Oviposition Choice in Drosophila\nmelanogaster: Good and Bad Cadavers?" + }, + { + "id": 182697, + "strid": "982c6f18-7f45-4be9-a88a-e834a08164e2", + "image_id": 207631, + "image_name": "8523.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 63.618, + 152.683, + 413.091, + 22.48400000000001 + ], + "priority": 2, + "parents": [ + 182721 + ], + "children": [], + "area": 9713.387094, + "iscrowd": 0, + "segmentation": [], + "text": "Jonathon Siva-Jothy, Katy Monteith & Pedro Vale" + }, + { + "id": 182698, + "strid": "b6f1ae91-76ce-461d-9b0b-b6f3a375f445", + "image_id": 207631, + "image_name": "8523.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 61.679, + 228.24, + 110.79600000000002, + 22.593999999999994 + ], + "priority": 3, + "parents": [ + 182721 + ], + "children": [ + 182702, + 182703 + ], + "area": 14077.61496, + "iscrowd": 0, + "segmentation": [], + "text": "Background" + }, + { + "id": 182702, + "strid": "587d5616-7f43-4477-b430-36baa318a0e8", + "image_id": 207631, + "image_name": "8523.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 55.477, + 259.375, + 276.045, + 118.78899999999999 + ], + "priority": 4, + "parents": [ + 182698 + ], + "children": [], + "area": 14389.346875, + "iscrowd": 0, + "segmentation": [], + "text": "Fly cadavers offer extra nutrients to offspring but can\nharbor pathogens. Given the cast of Drosophila C\nVirus (DCW) infection, selection should favor egg-\nlaying females able to identify uninfected cadavers.\n\nWe tested females for oviposition preference, whether\nthis changes under infection and the fitness cost of\nthis preference." + }, + { + "id": 182703, + "strid": "d9c969c5-1015-4cbc-91b2-045d7f4b614e", + "image_id": 207631, + "image_name": "8523.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 74.635, + 403.255, + 244.84700000000004, + 103.13499999999999 + ], + "priority": 5, + "parents": [ + 182698 + ], + "children": [], + "area": 30096.936925, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 182700, + "strid": "29016946-148e-49a0-8cd0-6b9640e9fe8b", + "image_id": 207631, + "image_name": "8523.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 65.454, + 547.793, + 70.39400000000002, + 20.027000000000044 + ], + "priority": 6, + "parents": [ + 182721 + ], + "children": [ + 182707, + 182704, + 182706, + 182705 + ], + "area": 35855.243021999995, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 182704, + "strid": "2a3a1191-9570-46f4-a3ac-c4a6ee1d4521", + "image_id": 207631, + "image_name": "8523.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 64.891, + 580.447, + 255.247, + 43.226999999999975 + ], + "priority": 7, + "parents": [ + 182700 + ], + "children": [], + "area": 37665.78627700001, + "iscrowd": 0, + "segmentation": [], + "text": "Cadaver Preference (fig. 2)\nFemales lay significantly more eggs on sites where\ncadavers are present." + }, + { + "id": 182705, + "strid": "d16a3633-2c5b-4b9f-8796-800597a9fbe3", + "image_id": 207631, + "image_name": "8523.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 64.258, + 639.889, + 262.624, + 55.10900000000004 + ], + "priority": 8, + "parents": [ + 182700 + ], + "children": [], + "area": 41117.987362, + "iscrowd": 0, + "segmentation": [], + "text": "Avoiding Infected Cadavers (fig. 2)\n\nUninfected mothers oviposit mare on sham cadaver\nsites. This preference is not seen in the following 24\nhours." + }, + { + "id": 182706, + "strid": "0afd0569-bb21-4f9a-8347-4aa1ee2418e1", + "image_id": 207631, + "image_name": "8523.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 64.936, + 713.644, + 261.168, + 42.37699999999995 + ], + "priority": 9, + "parents": [ + 182700 + ], + "children": [], + "area": 46341.186784000005, + "iscrowd": 0, + "segmentation": [], + "text": "Infected Mother's Oviposition Choice (fig. 2)\nInfected mothers did not distinguish between sham\nand infected cadaver sites." + }, + { + "id": 182707, + "strid": "61661257-a5b6-4801-981e-39b0f4875a95", + "image_id": 207631, + "image_name": "8523.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 65.271, + 773.081, + 260.753, + 56.474000000000046 + ], + "priority": 10, + "parents": [ + 182700 + ], + "children": [], + "area": 50459.769951, + "iscrowd": 0, + "segmentation": [], + "text": "Oviposition Choice and Offspring Fitness (fig. 4)\nSham site offepring survive to adulthood more than\ncontrol site offspring. Infected site offepring survival\nlies between these two treatments." + }, + { + "id": 182699, + "strid": "491884a6-6f22-4beb-8d11-fd644510010c", + "image_id": 207631, + "image_name": "8523.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 366.793, + 227.612, + 193.534, + 21.129999999999995 + ], + "priority": 11, + "parents": [ + 182721 + ], + "children": [ + 182713, + 182709, + 182708, + 182717, + 182715, + 182710, + 182711 + ], + "area": 83486.488316, + "iscrowd": 0, + "segmentation": [], + "text": "Materials & Methods" + }, + { + "id": 182708, + "strid": "24093b70-7498-4f1b-8830-c119b91466b1", + "image_id": 207631, + "image_name": "8523.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 359.71, + 258.124, + 400.84600000000006, + 41.09300000000002 + ], + "priority": 12, + "parents": [ + 182699 + ], + "children": [], + "area": 92849.78404, + "iscrowd": 0, + "segmentation": [], + "text": "Mated Oregon R females were infected with Drosophila C Virus (10° TCIDg,) via\nthoracic pricking and left for 72 he. ’Sham’ flies were picked with Tris HCI\nsolution as a control for infection protocol." + }, + { + "id": 182709, + "strid": "385800aa-dda8-425e-92c8-08359163475e", + "image_id": 207631, + "image_name": "8523.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 359.744, + 312.013, + 364.2610000000001, + 54.721000000000004 + ], + "priority": 13, + "parents": [ + 182699 + ], + "children": [], + "area": 112244.804672, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 182710, + "strid": "897355ba-2bcf-48e5-9721-bc527c4a9aef", + "image_id": 207631, + "image_name": "8523.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 359.556, + 380.595, + 403.03399999999993, + 40.81299999999999 + ], + "priority": 14, + "parents": [ + 182699 + ], + "children": [], + "area": 136845.21582, + "iscrowd": 0, + "segmentation": [], + "text": "Females were left to lay eggs for 45 hours with eqgs counted once a day.\nAfterwards, eggs were allowed to develop and their adult mortality tracked (see\nfig. 3)." + }, + { + "id": 182711, + "strid": "ebb978f9-fd07-411b-86b7-534b48af874f", + "image_id": 207631, + "image_name": "8523.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 368.188, + 425.864, + 182.66099999999994, + 54.291 + ], + "priority": 15, + "parents": [ + 182699 + ], + "children": [ + 182712 + ], + "area": 156798.014432, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 182712, + "strid": "975680f6-5f4a-4728-a496-8005631d1ec8", + "image_id": 207631, + "image_name": "8523.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 567.934, + 432.046, + 177.09299999999996, + 31.26600000000002 + ], + "priority": 16, + "parents": [ + 182711 + ], + "children": [], + "area": 245373.61296399997, + "iscrowd": 0, + "segmentation": [], + "text": "fig. 1 = Choice chamber containing 3\nerica food cape, Mothers ded to the\npret" + }, + { + "id": 182713, + "strid": "d9ba8621-f17f-426e-9264-db8ed385357d", + "image_id": 207631, + "image_name": "8523.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 354.497, + 503.367, + 397.8999999999999, + 153.20999999999998 + ], + "priority": 17, + "parents": [ + 182699 + ], + "children": [ + 182714 + ], + "area": 178442.09139900003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 182714, + "strid": "6ab7ee5d-9138-41e1-830c-f14f637a8698", + "image_id": 207631, + "image_name": "8523.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 369.742, + 661.663, + 374.584, + 32.79099999999994 + ], + "priority": 18, + "parents": [ + 182713 + ], + "children": [], + "area": 244644.60094600002, + "iscrowd": 0, + "segmentation": [], + "text": "2 ~ Mean avipesition site propartions +SE (N=78), between infection treatments and 24hr\nte pris Dire aters denote shane (pe. 08) dete by gonelued ines\nmodel construction and Tukey HSD pea hoc analyta." + }, + { + "id": 182715, + "strid": "5e20054b-d7ff-4603-9870-2dcb2c46abbc", + "image_id": 207631, + "image_name": "8523.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 368.412, + 716.643, + 144.34099999999995, + 110.92600000000004 + ], + "priority": 19, + "parents": [ + 182699 + ], + "children": [ + 182716 + ], + "area": 264019.880916, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 182716, + "strid": "2d9b2c18-5e75-4b8e-b02d-00332146d446", + "image_id": 207631, + "image_name": "8523.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 364.029, + 841.157, + 146.676, + 20.29600000000005 + ], + "priority": 20, + "parents": [ + 182715 + ], + "children": [], + "area": 306205.541553, + "iscrowd": 0, + "segmentation": [], + "text": "fig. 3 ~ Vials for tracking egg to adult\nFo. ee" + }, + { + "id": 182717, + "strid": "0995862c-f17e-46b4-8b24-2e8592107514", + "image_id": 207631, + "image_name": "8523.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 533.723, + 700.248, + 216.437, + 132.98400000000004 + ], + "priority": 21, + "parents": [ + 182699 + ], + "children": [ + 182718 + ], + "area": 373738.463304, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 182718, + "strid": "b09660ce-e659-44ff-b949-5c3c872d6505", + "image_id": 207631, + "image_name": "8523.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 541.989, + 835.78, + 173.32400000000007, + 31.397000000000048 + ], + "priority": 22, + "parents": [ + 182717 + ], + "children": [], + "area": 452983.56642, + "iscrowd": 0, + "segmentation": [], + "text": "'=SE Egg to adult survival rates\nocr ilecion il oupeaiton ste\nee ee ae." + }, + { + "id": 182701, + "strid": "9e86eac3-3bcd-463f-90e2-d086f9b29903", + "image_id": 207631, + "image_name": "8523.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 61.992, + 878.306, + 104.45400000000001, + 19.144999999999982 + ], + "priority": 23, + "parents": [ + 182721 + ], + "children": [ + 182719 + ], + "area": 54447.945552, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion" + }, + { + "id": 182719, + "strid": "c7d890b4-a07f-4789-b45a-2d2b18631461", + "image_id": 207631, + "image_name": "8523.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 65.77, + 906.939, + 482.19100000000003, + 184.9419999999999 + ], + "priority": 24, + "parents": [ + 182701 + ], + "children": [], + "area": 59649.37802999999, + "iscrowd": 0, + "segmentation": [], + "text": "Females laid significantly more eggs on cadaver sites indicating an oviposition preference.\n\nUninfected mothers ovipesited more on uninfected cadavers in the fist 24 hours but not in the\nfollowing 24 hours. Ths is likely a response to overcrowding in the uninfected cadaver site. The\npotential fitness cost of exposure to an infectious site is not greater than the fitness benefits of\n\nlaying more eggs.\n\n \n\ninfected females did net differentiate between infected and uninfected cadavers. Indicating the\ninfection risk from infected cadavers is irrelevant in the context oftheir own vical load.\n\nIncreased sham site offspring survival indicates selection drives oviposition preference for\nuninfected cadaver sites by enhancing offspring fitness. However, infected site offspring survival\nnot differing from control and sham sites suggests this i not driving pathogen avoidance.\nAlternative selection pressures could be infection affecting offspring fecundity or health." + }, + { + "id": 182720, + "strid": "b311a1ff-98d1-4628-a85a-300a97e7dfcb", + "image_id": 207631, + "image_name": "8523.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 568.409, + 937.253, + 183.827, + 120.20500000000004 + ], + "priority": 25, + "parents": [ + 182721 + ], + "children": [], + "area": 532743.0404770001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 168582, + "strid": "a91f2bcd-6edc-4d8a-8e52-237927ea3d15", + "image_id": 207086, + "image_name": "6947.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 110.71, + 67.77, + 255.42000000000002, + 242.65000000000003 + ], + "priority": -1, + "parents": [], + "children": [ + 168561, + 168560, + 168557, + 168559, + 168558 + ], + "area": 7502.816699999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 168557, + "strid": "69ebc70c-f8bc-4af1-9549-aa9b0ccb377c", + "image_id": 207086, + "image_name": "6947.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 708.156, + 83.705, + 1859.484, + 265.222 + ], + "priority": 1, + "parents": [ + 168582 + ], + "children": [], + "area": 59276.19798, + "iscrowd": 0, + "segmentation": [], + "text": "The Role of Stereoscopic Depth Cues\nin Place Recognition" + }, + { + "id": 168558, + "strid": "94e0f8d3-4b64-4b5f-b366-a6ccea8af385", + "image_id": 207086, + "image_name": "6947.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 846.352, + 437.335, + 1612.571, + 67.74000000000001 + ], + "priority": 2, + "parents": [ + 168582 + ], + "children": [], + "area": 370139.35192, + "iscrowd": 0, + "segmentation": [], + "text": "Marc Halfmann, Viktoria Prozmann & Hanspeter A. Mallot" + }, + { + "id": 168559, + "strid": "a11a8c3b-7943-4cbb-a4c2-2a994fe31e98", + "image_id": 207086, + "image_name": "6947.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 139.97, + 741.529, + 553.12, + 72.44100000000003 + ], + "priority": 3, + "parents": [ + 168582 + ], + "children": [ + 168562 + ], + "area": 103791.81413, + "iscrowd": 0, + "segmentation": [], + "text": "Place Recognition" + }, + { + "id": 168562, + "strid": "549d8cf9-4b2f-48d2-8711-13e6b180735f", + "image_id": 207086, + "image_name": "6947.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 134.899, + 887.257, + 1437.21, + 475.99699999999996 + ], + "priority": 4, + "parents": [ + 168559 + ], + "children": [], + "area": 119690.08204299999, + "iscrowd": 0, + "segmentation": [], + "text": "The recognition of places is based on local position information, i.e. the totality\nof sensory cues available from each place. Gillner et al. (Cognition 2008)\nshowed that place recognition can be based on raw snapshot information.\nHere we address the question if place recognition is possible also with pure\ndepth information. To test this we designed a virtual environment that is\npresented as a dynamic pattern of random dots with limited lifetime. A mirror\nstereoscope was used to ensure that participants could perceive a 3D\nimpression from stereoscopic and motion parallax cues. Presenting a stimulus\nin this way, all other cues but depth information were excluded." + }, + { + "id": 168560, + "strid": "899a505a-c027-4d0b-851b-d9f17b45ff9c", + "image_id": 207086, + "image_name": "6947.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 140.994, + 1428.317, + 610.241, + 71.80299999999988 + ], + "priority": 5, + "parents": [ + 168582 + ], + "children": [ + 168568, + 168563, + 168564, + 168567, + 168579, + 168566, + 168577, + 168578, + 168565 + ], + "area": 201384.127098, + "iscrowd": 0, + "segmentation": [], + "text": "> deleeantsaleclMY=1a0) ©" + }, + { + "id": 168563, + "strid": "17faa537-a99e-42f5-a4ae-3d0e616dddeb", + "image_id": 207086, + "image_name": "6947.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 158.198, + 1595.527, + 1134.453, + 116.08199999999988 + ], + "priority": 6, + "parents": [ + 168560 + ], + "children": [], + "area": 252409.180346, + "iscrowd": 0, + "segmentation": [], + "text": "Question\nIs place recognition possible based on depth information only?" + }, + { + "id": 168564, + "strid": "641a7b8a-40a9-4c1e-b6af-5830cf1698db", + "image_id": 207086, + "image_name": "6947.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 133.921, + 1838.651, + 1434.214, + 224.04099999999994 + ], + "priority": 7, + "parents": [ + 168560 + ], + "children": [], + "area": 246233.980571, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 168577, + "strid": "1e52059f-1135-40f1-8e8b-f9b1f06d363a", + "image_id": 207086, + "image_name": "6947.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 137.24, + 2104.262, + 672.447, + 541.9490000000001 + ], + "priority": 8, + "parents": [ + 168560 + ], + "children": [ + 168574 + ], + "area": 288788.91688000003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 168574, + "strid": "166c4ddc-e1c0-44e7-82fc-e875173de70b", + "image_id": 207086, + "image_name": "6947.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 168.524, + 2656.599, + 778.515, + 96.7800000000002 + ], + "priority": 9, + "parents": [ + 168577 + ], + "children": [], + "area": 447700.68987600005, + "iscrowd": 0, + "segmentation": [], + "text": "Layout of the stereoscope: subject views the right monitor with the\nright eye and the mirrored image of the left monitor with the left\neye. Images are shifted by a small amount to perceive 3D impression" + }, + { + "id": 168578, + "strid": "06931a5b-cf21-4cc8-add7-a8b4213fab3c", + "image_id": 207086, + "image_name": "6947.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1069.148, + 2111.938, + 340.82899999999995, + 529.6669999999999 + ], + "priority": 10, + "parents": [ + 168560 + ], + "children": [ + 168575 + ], + "area": 2257974.288824, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 168575, + "strid": "ada981fa-9db7-4348-9a82-824e407dce66", + "image_id": 207086, + "image_name": "6947.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1063.322, + 2656.713, + 486.13200000000006, + 95.78999999999996 + ], + "priority": 11, + "parents": [ + 168578 + ], + "children": [], + "area": 2824941.3805859997, + "iscrowd": 0, + "segmentation": [], + "text": "Kite-shaped room: the three goal positions\nand the respective correct area as defined\nby Voronoi cells" + }, + { + "id": 168565, + "strid": "45f42256-42ff-4247-8e44-d302579c0f8e", + "image_id": 207086, + "image_name": "6947.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 138.673, + 2776.144, + 1405.58, + 103.50599999999986 + ], + "priority": 12, + "parents": [ + 168560 + ], + "children": [], + "area": 384976.216912, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 168566, + "strid": "3ff90919-2174-4707-bf23-b5587dcbc1ee", + "image_id": 207086, + "image_name": "6947.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 136.573, + 2972.427, + 1432.896, + 383.39300000000003 + ], + "priority": 13, + "parents": [ + 168560 + ], + "children": [], + "area": 405953.27267100004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 168579, + "strid": "f2fbc1e6-1df0-49ec-a2d8-53e4ef71feb7", + "image_id": 207086, + "image_name": "6947.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 146.818, + 3402.806, + 1436.572, + 389.3000000000002 + ], + "priority": 14, + "parents": 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"category_name": "Title", + "bbox": [ + 664.179, + 107.959, + 2158.559, + 206.478 + ], + "priority": 1, + "parents": [ + 76004 + ], + "children": [], + "area": 71704.100661, + "iscrowd": 0, + "segmentation": [], + "text": "Relationships between Resting State fMRI and EEG Brain\nConnectivity Across Frequency Bands" + }, + { + "id": 75969, + "strid": "2621c554-6e7a-4c7c-8d83-77ffec580d8b", + "image_id": 203462, + "image_name": "120280.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 736.611, + 335.817, + 1827.603, + 175.291 + ], + "priority": 2, + "parents": [ + 76004 + ], + "children": [], + "area": 247366.496187, + "iscrowd": 0, + "segmentation": [], + "text": "Fani Deligianni’, Maria Centeno, David W. Carmichael and Jonathan D. Clayden\n\nImaging and Biophysics Unit, UCL Institute of Child Health, London, UK\n“f.deligianni@ucl.ac.uk" + }, + { + "id": 75970, + "strid": "a76c53d6-ceb0-4e43-8ec8-cc58db867bfd", + "image_id": 203462, + "image_name": "120280.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 109.579, + 695.675, + 268.889, + 51.440000000000055 + ], + "priority": 3, + "parents": [ + 76004 + ], + "children": [ + 75982, + 75977, + 75976, + 75975, + 75998, + 75978, + 75979, + 75980, + 75981 + ], + "area": 76231.37082499999, + "iscrowd": 0, + "segmentation": [], + "text": "Background" + }, + { + "id": 75975, + "strid": "4a66a860-35a1-47f7-ac76-e352030c0d98", + "image_id": 203462, + "image_name": "120280.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 109.599, + 751.944, + 846.843, + 415.9369999999999 + ], + "priority": 4, + "parents": [ + 75970 + ], + "children": [], + "area": 82412.31045599999, + "iscrowd": 0, + "segmentation": [], + "text": "Whole brain functional connectomes hold promise\nfor understanding human brain activity across a range\nof cognitive and pathological states. Resting-state (rs)\nfunctional MRI studies have contributed to the brain\nbeing considered at a macroscopic scale as a set of\ninteracting regions. Interactions are defined as\ncorrelation-based signal measurements. The neuronal\nbasis of these interactions have been investigated\nbased on electrophysiological measurements:" + }, + { + "id": 75978, + "strid": "e6ef9e65-c0a1-4b6d-9e1e-78557cc68de9", + "image_id": 203462, + "image_name": "120280.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 110.704, + 1173.554, + 1362.208, + 198.11300000000006 + ], + "priority": 5, + "parents": [ + 75970 + ], + "children": [], + "area": 129917.12201600001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 75976, + "strid": "62eff132-c813-46ac-bcb3-b31b11f79812", + "image_id": 203462, + "image_name": "120280.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 108.395, + 1386.917, + 1268.201, + 88.46800000000007 + ], + "priority": 6, + "parents": [ + 75970 + ], + "children": [], + "area": 150334.868215, + "iscrowd": 0, + "segmentation": [], + "text": "However, the coupling/relationship/neurophsiological basis of whole brain rs\nconnectivity is less well understood?" + }, + { + "id": 75998, + "strid": "717b154a-faa5-4dcd-89ec-0b4d29c9990a", + "image_id": 203462, + "image_name": "120280.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 986.978, + 711.651, + 1282.812, + 361.456 + ], + "priority": 7, + "parents": [ + 75970 + ], + "children": [ + 75999 + ], + "area": 702383.8806779999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 75999, + "strid": "c1138399-959c-4156-bf3a-2fab26a00ac0", + "image_id": 203462, + "image_name": "120280.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 997.085, + 1088.341, + 1260.554, + 37.28600000000006 + ], + "priority": 8, + "parents": [ + 75998 + ], + "children": [], + "area": 1085168.485985, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 1: Exploring the relationship between EEG and fMRI with a prediction framework!" + }, + { + "id": 75979, + "strid": "da4e3823-901b-4bc5-a2ec-1a99d02387f9", + "image_id": 203462, + "image_name": "120280.png", + "category_id": 4, + 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"children": [], + "area": 599133.7797900001, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 2: Average brain connectomes across subjects for fMRI and each EEG band, respectively." + }, + { + "id": 75988, + "strid": "f1043095-2a14-41e3-9d52-420314665d7e", + "image_id": 203462, + "image_name": "120280.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 138.595, + 3771.758, + 1419.092, + 597.6670000000004 + ], + "priority": 29, + "parents": [ + 75974 + ], + "children": [ + 75991 + ], + "area": 522746.80000999995, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 75991, + "strid": "14887e96-2a34-45a2-9bb6-98fa690ffa5e", + "image_id": 203462, + "image_name": "120280.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 164.208, + 4383.64, + 1324.949, + 75.39900000000034 + ], + "priority": 30, + "parents": [ + 75988 + ], + "children": [], + "area": 719828.7571200001, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 4 shows the 2% connections with the highest probability to be selected in 10000 sCCA\niterations with sampling with replacement." + }, + { + "id": 75987, + "strid": "ae414006-3a6e-4f93-a7d1-46dfcb4f3e43", + "image_id": 203462, + "image_name": "120280.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1930.692, + 3147.398, + 1082.194, + 726.2399999999998 + ], + "priority": 31, + "parents": [ + 75974 + ], + "children": [ + 75990 + ], + "area": 6076656.139416, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 75990, + "strid": "75825ffe-f7db-4911-883d-56c100b0d915", + "image_id": 203462, + "image_name": "120280.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1809.705, + 3887.753, + 1332.958, + 115.08100000000013 + ], + "priority": 32, + "parents": [ + 75987 + ], + "children": [], + "area": 7035686.042865, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 3: The white boxplots indicate the intra-subject comparison between EEG and fMRI\nconnectomes, the green boxplots indicate the prediction performance of EEG from fMRI and\nvice-versa is shown with the brown boxplots." + }, + { + "id": 75973, + "strid": "0c707eba-7321-4abc-a582-6bb02d9e18c2", + "image_id": 203462, + "image_name": "120280.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1732.444, + 4051.755, + 262.221, + 41.03600000000006 + ], + "priority": 33, + "parents": [ + 76004 + ], + "children": [ + 75984 + ], + "area": 7019438.63922, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 75984, + "strid": "9f2fb43c-6903-49e6-b62a-5edb7b5c1de9", + "image_id": 203462, + "image_name": "120280.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1730.677, + 4107.358, + 1440.7390000000003, + 367.89900000000034 + ], + "priority": 34, + "parents": [ + 75973 + ], + "children": [], + "area": 7108510.021366, + "iscrowd": 0, + "segmentation": [], + "text": "This finding has several important implications. It shows that there are signatures of rs-\nfMRI dynamics across EEG frequencies, consistent with the concept of nested oscillations\nfound within EEG and it likely reflects the greater dynamic information content captured\nby EEG. This implies that scalp EEG can be used to provide similar information to rs-fMRI\nbased cortical connectomes at substantially reduced cost while providing much greater\ndynamic information content. This might be because of the coarse brain parcellation, which\nlimits spatial resolution to the size of the underling cortical regions. However, most current\nfMRI studies tend to examine connectivity at this scale." + }, + { + "id": 75972, + "strid": "c0642af0-e16d-468b-b571-665b558bc305", + "image_id": 203462, + "image_name": "120280.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 121.999, + 4507.103, + 256.26699999999994, + 42.36999999999989 + ], + "priority": 35, + "parents": [ + 76004 + ], + "children": [ + 75985 + ], + "area": 549862.058897, + "iscrowd": 0, + "segmentation": [], + "text": "References:" + }, + { + "id": 75985, + "strid": "62bc5ee0-3abf-4c94-b341-27e2045cf8f4", + "image_id": 203462, + "image_name": "120280.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 388.669, + 4519.292, + 2767.642, + 34.677999999999884 + ], + "priority": 36, + "parents": [ + 75972 + ], + "children": [], + "area": 1756508.7023480001, + "iscrowd": 0, + "segmentation": [], + "text": "[1] Deligianni et al. IEEE Trans Med Imag 2013 [2] Brookes et al. NeuroImage 2011 [3] Schafer, J. et al. Statist Appl Genet Mol Biol 2005 [4] Witten et al. Stat Appl Genet Mol Biol 2009 [5] Penny et al. J Neurosci Meth 2008" + }, + { + "id": 119395, + "strid": "c63319f1-aff1-4e7b-a020-5de3c5a038aa", + "image_id": 205145, + "image_name": "14354.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 2340.07, + 58.59, + 521.5799999999999, + 154.85 + ], + "priority": -1, + "parents": [], + "children": [ + 119377, + 119376, + 119375 + ], + "area": 137104.70130000002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 119375, + "strid": "52f241a1-0842-408a-b56f-86df8d71914f", + "image_id": 205145, + "image_name": "14354.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 115.875, + 84.513, + 2049.575, + 267.336 + ], + "priority": 1, + "parents": [ + 119395 + ], + "children": [], + "area": 9792.943875, + "iscrowd": 0, + "segmentation": [], + "text": "Gene Ontology Annotation (GOA)\nDatabase" + }, + { + "id": 119376, + "strid": "2c2c1a8a-d6f6-419e-8aa2-c91b2f3d8531", + "image_id": 205145, + "image_name": "14354.png", + "category_id": 0, + "category_name": 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million species." + }, + { + "id": 119392, + "strid": "6b4e182d-f964-4684-ab37-1089484dcf76", + "image_id": 205145, + "image_name": "14354.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 144.379, + 4135.275, + 1334.441, + 284.058 + ], + "priority": 19, + "parents": [ + 119377 + ], + "children": [], + "area": 597046.8692249999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 119390, + "strid": "c4d024fc-c0eb-4fe8-a5fe-aa91d56acfdf", + "image_id": 205145, + "image_name": "14354.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1574.667, + 4167.09, + 1544.063, + 212.8040000000001 + ], + "priority": 20, + "parents": [ + 119377 + ], + "children": [], + "area": 6561779.10903, + "iscrowd": 0, + "segmentation": [], + "text": "A major focus over the past year has been to increase the coverage of\nmanually assigned GO terms to the human proteome. More than 85% of the\n\nproteins in the human proteome now have manually assigned terms and\nthis work is ongoing." + }, + { + "id": 165913, + "strid": "0077bcd7-4c5d-4494-9e9a-c957ddf2dded", + "image_id": 206973, + "image_name": "6726.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 19.62, + 11.49, + 108.88999999999999, + 89.09 + ], + "priority": -1, + "parents": [], + "children": [ + 165904, + 165902, + 165908, + 165906, + 165909, + 165910, + 165912, + 165903, + 165911, + 165907, + 165905 + ], + "area": 225.43380000000002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 165902, + "strid": "abbc6458-9015-488b-8d05-8a034812b8d0", + "image_id": 206973, + "image_name": "6726.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 262.477, + 26.193, + 1344.571, + 73.253 + ], + "priority": 1, + "parents": [ + 165913 + ], + "children": [], + "area": 6875.060061, + "iscrowd": 0, + "segmentation": [], + "text": "PULSED ELECTROMAGNETIC FIELDS IN KNEE OSTEOARTHRITIS: A DOUBLE BLIND,\nPLACEBO-CONTROLLED, RANDOMIZED CLINICAL TRIAL" + }, + { + "id": 165903, + "strid": "2676bad6-5759-432e-b9f8-df52de373730", + "image_id": 206973, + "image_name": "6726.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 75.905, + 133.856, + 1033.575, + 67.08699999999999 + ], + "priority": 2, + "parents": [ + 165913 + ], + "children": [], + "area": 10160.33968, + "iscrowd": 0, + "segmentation": [], + "text": "Gianluca Bagnato, Giovanni Miceli, Natale Marino, Davide Sciortino, Gianfilippo Bagnato\n\nDivision of Rheumatology, Department of Clinical and Experimental Medicine, University of Messina, Italy" + }, + { + "id": 165904, + "strid": "9cd65ba7-8988-4c57-b317-85575a8348bd", + "image_id": 206973, + "image_name": "6726.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 48.079, + 244.725, + 449.07, + 482.052 + ], + "priority": 3, + "parents": [ + 165913 + ], + "children": [], + "area": 11766.133275, + "iscrowd": 0, + "segmentation": [], + "text": "Conservative and effective approaches for\nrelieving pain are needed for knee\nosteoarthritis (OA) patients and among\nthese, pulsed electromagnetic fields (PEMF)\nare emerging with promising results.\n\nThe aim of the study is therefore to evaluate\nthe efficacy on pain intensity reduction,\nmeasured by visual analogue score (VAS)\nand Western Ontario and McMaster\nUniversities Osteoarthritis Index (WOMAC),\nin patients affected by knee osteoarthritis\ntreated for 1 month with a wearable device\nusing pulsed electromagnetic _ fields.\nSecondary aim is to evaluate pain threshold,\nmeasured by an algometer, and quality of life\nimprovements and the changes on non-\nsteroidal anti-inflammatory drugs\n(NSAIDs)/analgesics intake." + }, + { + "id": 165906, + "strid": "49dbbab6-b0ba-4997-bd53-fe9a0caa479a", + "image_id": 206973, + "image_name": "6726.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 61.3, + 759.462, + 450.984, + 414.1010000000001 + ], + "priority": 4, + "parents": [ + 165913 + ], + "children": [], + "area": 46555.020599999996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 165908, + "strid": "5a2186d2-d137-4340-8d4a-4f19ffa40a6b", + "image_id": 206973, + "image_name": "6726.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 45.807, + 1228.433, + 451.026, + 212.8789999999999 + ], + "priority": 5, + "parents": [ + 165913 + ], + "children": [], + "area": 56270.830431, + "iscrowd": 0, + "segmentation": [], + "text": "This randomized, double-blind, placebo-\ncontrolled clinical trial, with equal\nrandomization (1:1), parallel group study, has\nbeen approved by local ethics committee and\nperformed in compliance with the Helsinki\nDeclaration and ICH-GCP. This trial was\nregistered on Clinicaltrial.gov\n(NCT01877278)." + }, + { + "id": 165905, + "strid": "b8ca0460-322e-4c5e-ae63-03204fd1c2fe", + "image_id": 206973, + "image_name": "6726.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 536.818, + 246.014, + 500.5339999999999, + 553.615 + ], + "priority": 6, + "parents": [ + 165913 + ], + "children": [], + "area": 132064.743452, + "iscrowd": 0, + "segmentation": [], + "text": "Enrolled patients affected by knee OA were\nrandomly allocated in 2 groups:\npulse electromagnetic fields wearable device\n(PEMF group) and placebo group. The device is\nmanufactured by Bioelectronics corporation, MD,\nUSA (www.bielcorp.com), and is commercially\navailable. It is a pulsed radiofrequency energy\ndevice (ActiPatch) that emits a safe form of\nnonionizing electromagnetic radiation. The carrier\nfrequency is 27.12 MHz, and it has a pulse rate of\n1000 Hz and a 100-p/s burst width. The peak burst\noutput power of the 12-cm antenna is\napproximately 0.0098 W and covers a surface\narea of approximate 103 cm2. The circuitry\nconsists of low voltage (3 V) digital/analog\nelectronics that control all timing functions to\nproduce the therapeutic radiofrequency field, with\nthe antenna field placed directly above the\ntherapeutic site. The placebo devices do not emit\na radiofrequency electromagnetic field but will be\nidentical to the active devices." + }, + { + "id": 165907, + "strid": "9fbde46d-4d12-4c22-b1e6-75667b0bcebb", + "image_id": 206973, + "image_name": "6726.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 596.135, + 830.644, + 380.775, + 239.25299999999993 + ], + "priority": 7, + "parents": [ + 165913 + ], + "children": [], + "area": 495175.96094, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 165909, + "strid": "5209ab29-7e0a-4b33-9403-c5eceb589176", + "image_id": 206973, + "image_name": "6726.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 535.155, + 1096.2, + 502.193, + 348.48199999999997 + ], + "priority": 8, + "parents": [ + 165913 + ], + "children": [], + "area": 586636.911, + "iscrowd": 0, + "segmentation": [], + "text": "The device was worn for a minimum of twelve\nconsecutive hours mainly at night with the\nantenna placed over the knee. The primary\noutcome measure was the pain score\nimprovement response to treatment from baseline\nto 1 months posttreatment in VAS and WOMAC\nscores. Secondary end point was to evaluate\nchanges in quality of life (SF-36), in daily intake of\nanalgesics per week and in pain threshold\nmeasured by a pressure algometer (Wagner\nInstruments, http://wagnerforce.com) applied on\nthe anterior aspect of the thigh (QDR) and the\ndistal interphalangeal joint (DIP)." + }, + { + "id": 165912, + "strid": "9b69b30c-4468-4a34-838d-84ec5d3f4cd8", + "image_id": 206973, + "image_name": "6726.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1071.825, + 260.745, + 837.4849999999999, + 14.16500000000002 + ], + "priority": 9, + "parents": [ + 165913 + ], + "children": [], + "area": 279473.009625, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 165911, + "strid": "3dd90230-9fc9-4dd6-92fd-be2d4170169d", + "image_id": 206973, + "image_name": "6726.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1071.809, + 295.076, + 1021.249, + 477.03 + ], + "priority": 10, + "parents": [ + 165913 + ], + "children": [], + "area": 316265.11248400004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 165910, + "strid": "fd6cc04e-81e2-44f9-b8fc-74edb1422847", + "image_id": 206973, + "image_name": "6726.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1064.536, + 817.063, + 1029.0079999999998, + 607.986 + ], + "priority": 11, + "parents": [ + 165913 + ], + "children": [], + "area": 869792.977768, + "iscrowd": 0, + "segmentation": [], + "text": "Each group comprised 30 (PEFM group) and 30 (placebo group) completers.\n\nAs initial analysis we sought to analyze primary outcome in the PEMF and placebo groups. In patients\ntreated with the PEMF device, we found that VAS pain and WOMAC pain scores significantly decreased\nafter 1 month of treatment compared to placebo. Consistently, WOMAC stiffness and function scores\nimproved after PEMF treatment (Table). After 1 month of treatment, there was a 25.5% reduction in VAS\npain scores for subjects treated with the PEMF device and a 3.6% reduction in those who received\nplacebo with a standardised effect size of -0.71 (95% confidence interval Cl = -1.23 to -0.18) in VAS\nscore.\n\nThere was a 23.4% reduction in WOMAC pain subscale and 18.4% reduction in WOMAC total score\ncompared to 2.3% reduction both for WOMAC pain and total in the placebo group. The standardized\neffect size was for WOMAC pain -0.61 (95% confidence interval Cl = -1.12 to -0.09) and -0.34\n(95% confidence interval Cl = -0.85 to 0.17) for WOMAC total score ( Figure A).\n\nBoth measurements of pressure pain threshold improve in OA patients after 1 month of treatment with\nPEMF device compared to placebo. Next, we assessed whether quality of life, measured through the\nSF-36 questionnaire, was modified by the treatment. Only physical health scores improved in the PEMF\ngroup (Table). Among the patients from the PEMF group 8 patients (26%) stopped previously prescribed\nmedications, while in the placebo group 1 patient (3%) stopped and 10 (30%) started a new therapy for\nchronic pain.\n\nTaken together, these results suggest that pulsed electromagnetic fields therapy is a plausible\nalternative for the treatment of chronic pain in knee OA. The possibility that part of the effects of this\ntherapeutic approach can derive from neuromodulation of pain mechanism needs to be further explored\nin order to identify the interactions between cartilage function, pain perception and electromagnetic\nfields." + }, + { + "id": 57107, + "strid": "986d00f6-66ec-4479-af2d-28e9e0866cf6", + "image_id": 202751, + "image_name": "119184.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 15.83, + 267.82, + 100.57000000000001, + 60.34000000000003 + ], + "priority": -1, + "parents": [], + "children": [ + 57087, + 57098, + 57100, + 57084, + 57086, + 57097, + 57085, + 57088 + ], + "area": 4239.5905999999995, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 57084, + "strid": "11461b86-0536-4af3-9c75-2e43d665e9d4", + "image_id": 202751, + "image_name": "119184.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 64.861, + 90.758, + 1372.069, + 139.16700000000003 + ], + "priority": 1, + "parents": [ + 57107 + ], + "children": [], + "area": 5886.654638, + "iscrowd": 0, + "segmentation": [], + "text": "Compliance of a ventilator-associated pneumonia\ncare bundle in an adult intensive care setting" + }, + { + "id": 57085, + "strid": "617fa865-ca6c-4d8a-9ed7-5a74503b639d", + "image_id": 202751, + "image_name": "119184.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 333.401, + 223.228, + 833.8039999999999, + 81.86599999999999 + ], + "priority": 2, + "parents": [ + 57107 + ], + "children": [], + "area": 74424.43842800001, + "iscrowd": 0, + "segmentation": [], + "text": "G Wigmore| R Sethuraman\nThe Princess Alexandra Hospital NHS Trust, Harlow, UK" + }, + { + "id": 57086, + "strid": "bdd4e15b-d78f-4cab-89b3-206163bf8090", + "image_id": 202751, + "image_name": "119184.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 622.925, + 362.323, + 257.14, + 29.834000000000003 + ], + "priority": 3, + "parents": [ + 57107 + ], + "children": [ + 57089 + ], + "area": 225700.05477499997, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 57089, + "strid": "b0c3caae-e71c-4bcc-8823-c726f3c93525", + "image_id": 202751, + "image_name": "119184.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 48.742, + 410.241, + 1404.283, + 116.66200000000003 + ], + "priority": 4, + "parents": [ + 57086 + ], + "children": [], + "area": 19995.966822, + "iscrowd": 0, + "segmentation": [], + "text": "Ventilator-associated pneumonia (VAP) is the leading cause of death amongst hospital-acquired infections and is also linked to\nan increased length of stay and cost of care. The Institute for Healthcare Improvement ventilator bundle is comprised of a\nseries of interventions which, when implemented together, have been shown to. decrease the incidence of VAP. The aim of this\nstudy was to determine the compliance with the bundle and, if less than 95% [1] devise strategies to improve compliance." + }, + { + "id": 57087, + "strid": "b929bca9-5e9c-4242-a5d5-50aa2dad8bbb", + "image_id": 202751, + "image_name": "119184.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 618.679, + 544.248, + 266.4920000000001, + 29.192999999999984 + ], + "priority": 5, + "parents": [ + 57107 + ], + "children": [ + 57090 + ], + "area": 336714.80839200004, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 57090, + "strid": "86243ad6-346f-4f51-82e2-2368e26ef9bb", + "image_id": 202751, + "image_name": "119184.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 47.368, + 592.506, + 1396.806, + 268.00699999999995 + ], + "priority": 6, + "parents": [ + 57087 + ], + "children": [], + "area": 28065.824207999998, + "iscrowd": 0, + "segmentation": [], + "text": "A retrospective review of the compliance with an existing VAP bundle was conducted for all adult patients ventilated in the\nintensive care unit of a large district general hospital in 2011. The bundle comprised of four elements: head up 30 degrees;\npeptic ulcer prophylaxis; deep vein thrombosis (DVT) prophylaxis and sedation hold. The bundle was considered compliant if\nall four were performed. The initial findings revealed a compliance of less than 95%. These findings were presented to the\ndepartment and, through subsequent discussions, barriers to non-compliance were identified. Following a period of education,\na revised and updated bundle was implemented (Figure 1). A repeat audit covering three months was subsequently\nconducted.Date analysis was performed using StatsDirect (StatsDirect Ltd. StatsDirect statistical software. http://www.stats-\ndirect.com. England: StatsDirect Ltd. 2013). Differences in compliance were calculated with chi-squared test. P-values <0.05\nwere considered statistically significant." + }, + { + "id": 57088, + "strid": "4b01cf97-3cb5-49e5-8585-7aaa09ec2f0b", + "image_id": 202751, + "image_name": "119184.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 615.948, + 874.903, + 271.54499999999996, + 29.976 + ], + "priority": 7, + "parents": [ + 57107 + ], + "children": [ + 57103, + 57091, + 57104 + ], + "area": 538894.753044, + "iscrowd": 0, + "segmentation": [], + "text": "INTERVENTIONS" + }, + { + "id": 57091, + "strid": "214fa96a-5be8-4874-bfa0-8dade1e1df8e", + "image_id": 202751, + "image_name": "119184.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 48.775, + 924.228, + 1363.94, + 87.36099999999999 + ], + "priority": 8, + "parents": [ + 57088 + ], + "children": [], + "area": 45079.2207, + "iscrowd": 0, + "segmentation": [], + "text": "Interventions consisted of: (1) a revised care bundle incorporating cuff pressure measurements and oral hygiene along with\nthe addition of a N/A column (Figure 1); (2) an inclusion and exclusion policy for the bundle; (3) oral hygiene stickers for the\ndrug chart (Figure 2)." + }, + { + "id": 57104, + "strid": "90d5dba1-aaaf-411f-b148-64958b79a983", + "image_id": 202751, + "image_name": "119184.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 49.456, + 1026.839, + 695.569, + 338.97800000000007 + ], + "priority": 9, + "parents": [ + 57088 + ], + "children": [ + 57105 + ], + "area": 50783.349584, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 57105, + "strid": "7ff62ae7-b715-497d-a06e-27cb01431fe8", + "image_id": 202751, + "image_name": "119184.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 51.671, + 1370.553, + 146.741, + 19.8599999999999 + ], + "priority": 10, + "parents": [ + 57104 + ], + "children": [], + "area": 70817.84406300001, + "iscrowd": 0, + "segmentation": [], + "text": "Figure I: VAP bundle" + }, + { + "id": 57103, + "strid": "07f439f4-b742-431e-b9ae-66619d2ee0cf", + "image_id": 202751, + "image_name": "119184.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 834.905, + 1026.055, + 535.892, + 371.549 + ], + "priority": 11, + "parents": [ + 57088 + ], + "children": [ + 57106 + ], + "area": 856658.449775, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 57106, + "strid": "a99601c5-604c-42f6-80cc-96e7c0b40a5e", + "image_id": 202751, + "image_name": "119184.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 839.557, + 1402.152, + 205.30099999999993, + 19.05600000000004 + ], + "priority": 12, + "parents": [ + 57103 + ], + "children": [], + "area": 1177186.526664, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2: Oral hygiene stickers" + }, + { + "id": 57100, + "strid": "4d6ea5ca-e0d6-437d-8c28-99812106da58", + "image_id": 202751, + "image_name": "119184.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 675.883, + 1435.282, + 151.687, + 28.836000000000013 + ], + "priority": 13, + "parents": [ + 57107 + ], + "children": [ + 57093, + 57101, + 57094, + 57092, + 57095, + 57102 + ], + "area": 970082.704006, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 57092, + "strid": "4ca8a3ff-4b92-49c5-bdbf-47d04fb7448f", + "image_id": 202751, + "image_name": "119184.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 252.156, + 1495.716, + 286.31300000000005, + 26.97199999999998 + ], + "priority": 14, + "parents": [ + 57100 + ], + "children": [], + "area": 377153.763696, + "iscrowd": 0, + "segmentation": [], + "text": "Compliance of the bundle" + }, + { + "id": 57101, + "strid": "4501df37-6bdb-4c7e-8871-74fad89741fb", + "image_id": 202751, + "image_name": "119184.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 56.928, + 1561.107, + 673.509, + 472.105 + ], + "priority": 15, + "parents": [ + 57100 + ], + "children": [], + "area": 88870.69929599999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 57094, + "strid": "f23aa857-333e-4034-aa52-fd2f1786841b", + "image_id": 202751, + "image_name": "119184.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 48.806, + 2061.706, + 651.62, + 131.9409999999998 + ], + "priority": 16, + "parents": [ + 57100 + ], + "children": [], + "area": 100623.623036, + "iscrowd": 0, + "segmentation": [], + "text": "*Statistically different (P<0.05)\n\nPre-intervention, overall compliance of the bundle stood at\n32% and subsequently increased to 63% post-intervention\n(P<0.05)." + }, + { + "id": 57093, + "strid": "3f319604-f9ca-416f-b189-afcc61954219", + "image_id": 202751, + "image_name": "119184.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 838.234, + 1496.949, + 534.275, + 27.18399999999997 + ], + "priority": 17, + "parents": [ + 57100 + ], + "children": [], + "area": 1254793.5480660002, + "iscrowd": 0, + "segmentation": [], + "text": "Compliance of individual elements of the bundle" + }, + { + "id": 57102, + "strid": "90ed4a83-4b01-46d2-a0f0-bb6eac1b7558", + "image_id": 202751, + "image_name": "119184.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 764.034, + 1557.928, + 680.388, + 446.3889999999999 + ], + "priority": 18, + "parents": [ + 57100 + ], + "children": [], + "area": 1190309.9615520001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 57095, + "strid": "d5e336ee-de3a-4a23-8a75-815f7dc548b2", + "image_id": 202751, + "image_name": "119184.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 755.751, + 2010.549, + 644.2450000000001, + 252.59000000000015 + ], + "priority": 19, + "parents": [ + 57100 + ], + "children": [], + "area": 1519474.4172989998, + "iscrowd": 0, + "segmentation": [], + "text": "*Statistically different (P<0.05)\n\nCompliance at the level of individual elements varied from\n37% sedation hold to. 94% head up 30 degrees.\nPost-intervention, a statistically significant increase in\ncompliance with regard to sedation hold was observed;\n(P<0.05). The new elements that were introduced\ndemonstrated high levels of compliance: cuff pressure\n20-30 cm,H,O 83%; oral hygiene with chlorhexidine 90%." + }, + { + "id": 57097, + "strid": "23b92d3a-dee0-4899-9432-4517c32ae259", + "image_id": 202751, + "image_name": "119184.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 628.17, + 2282.803, + 244.96299999999997, + 29.0920000000001 + ], + "priority": 20, + "parents": [ + 57107 + ], + "children": [ + 57096 + ], + "area": 1433988.3605099998, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 57096, + "strid": "ccfc5e0a-7ccd-4ba3-95e3-cd5b47d5cdaa", + "image_id": 202751, + "image_name": "119184.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 47.653, + 2328.25, + 1384.707, + 113.29300000000012 + ], + "priority": 21, + "parents": [ + 57097 + ], + "children": [], + "area": 110948.09724999999, + "iscrowd": 0, + "segmentation": [], + "text": "Post-intervention, a statistically significant improvement in overall bundle compliance was found. By taking a multidisciplinary\napproach to patient-centred care processes, barriers to non-compliance were able to be identified and overcome. In order to\nachieve higher levels of compliance, a continuous cycle of compliance monitoring along with feedback to the multidisciplinary\n\nteam is critical." + }, + { + "id": 57098, + "strid": "a79c3ea5-ab77-4758-ad3a-da8c61bf4ecd", + "image_id": 202751, + "image_name": "119184.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 280.117, + 2465.202, + 229.538, + 29.26800000000003 + ], + "priority": 22, + "parents": [ + 57107 + ], + "children": [ + 57099 + ], + "area": 690544.9886340001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 57099, + "strid": "50a19d57-5e87-49b2-9e4b-9b8202005644", + "image_id": 202751, + "image_name": "119184.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 47.937, + 2513.978, + 675.214, + 88.6210000000001 + ], + "priority": 23, + "parents": [ + 57098 + ], + "children": [], + "area": 120512.563386, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 60994, + "strid": "8fcdc6f7-74b4-4a67-abaf-de4825f3cd89", + "image_id": 202907, + "image_name": "11943.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 124.53, + 140.44, + 138.67, + 170.67000000000002 + ], + "priority": -1, + "parents": [], + "children": [ + 60974, + 60976, + 60972, + 60971, + 60975, + 60970, + 60978, + 60977, + 60973 + ], + "area": 17488.9932, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 60970, + "strid": "e414fba6-c951-4000-9bc7-7dfefe455115", + "image_id": 202907, + "image_name": "11943.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 326.99, + 98.019, + 970.904, + 72.018 + ], + "priority": 1, + "parents": [ + 60994 + ], + "children": [], + "area": 32051.23281, + "iscrowd": 0, + "segmentation": [], + "text": "INFLUENCIA DE LA LUZ AZUL APLICADA A UN SOLO OJO EN\nYEGUAS EN EPOCA DE CICLAJE Y PREPARTO" + }, + { + "id": 60971, + "strid": "3da91c00-bdd7-48e0-922d-83ba8984091e", + "image_id": 202907, + "image_name": "11943.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 344.078, + 190.244, + 932.363, + 115.28900000000002 + ], + "priority": 2, + "parents": [ + 60994 + ], + "children": [], + "area": 65458.775032, + "iscrowd": 0, + "segmentation": [], + "text": "Bazan Santa Cruz, Sofia’; Lucana Salgado, Joel’; Placencia Lucano, Cintia’; Pineda Chavarria,\nRoberto\n\n‘Laboratorio de Computo Avanzado, Escuela Profesional de Medicina Veterinaria, Facultad de\nCiencias Bioldgicas, Universidad Ricardo Palma, Av. Benavides 5440 Santiago de Surco Lima Pert" + }, + { + "id": 60972, + "strid": "e0ee840d-3f28-4be9-96f1-e30d099bc88d", + "image_id": 202907, + "image_name": "11943.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 406.308, + 350.144, + 74.58799999999997, + 15.983000000000004 + ], + "priority": 3, + "parents": [ + 60994 + ], + "children": [ + 60979 + ], + "area": 142266.308352, + "iscrowd": 0, + "segmentation": [], + "text": "Resumen" + }, + { + "id": 60979, + "strid": "1f472b70-f33b-4a97-8af7-dba5f1a85d56", + "image_id": 202907, + "image_name": "11943.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 81.274, + 399.224, + 713.291, + 198.38299999999998 + ], + "priority": 4, + "parents": [ + 60972 + ], + "children": [], + "area": 32446.531376, + "iscrowd": 0, + "segmentation": [], + "text": "En el presente trabajo se evalud los efectos del fotoperiodo artificial respecto al ciclaje y la gestacién\nsegiin tres diferentes investigaciones. En dichos estudios se dividieron a las yeguas en muestras a las\ncuales a un primer grupo se le administré luz azul aplicada a un solo ojo; a un segundo grupo, luz blanca\nconvencional en sus potros respectivos, y a un tercer grupo, solo luz natural.\n\nLos resultados de este experimento fueron eficazmente positives en el acortamiento del periodo de\ntransicion tanto como el de gestacién. También hubo notable influencia en el incremento del peso del\npotro, enfocandonos en el hemisferio Norte.\n\nCabe resattar que el fotoperiodo es mas influyente en las yeguas (ciclaje estacional) que se encuentran\nen las latitudes altas, ya sea al Norte o al Sur del ecuador, ya que alla las estaciones son mas marcadas." + }, + { + "id": 60973, + "strid": "a25eb9c4-ee1b-4596-90dc-7c1567b034ca", + "image_id": 202907, + "image_name": "11943.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 392.633, + 619.902, + 102.70999999999998, + 16.480999999999995 + ], + "priority": 5, + "parents": [ + 60994 + ], + "children": [ + 60980 + ], + "area": 243393.981966, + "iscrowd": 0, + "segmentation": [], + "text": "Introduccion" + }, + { + "id": 60980, + "strid": "b37fa756-61af-465c-ad22-57b09c15dd1a", + "image_id": 202907, + "image_name": "11943.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 81.339, + 667.529, + 713.719, + 635.2249999999999 + ], + "priority": 6, + "parents": [ + 60973 + ], + "children": [], + "area": 54296.141331, + "iscrowd": 0, + "segmentation": [], + "text": "Los caballos tienen una temporada de apareamiento que se extiende desde abril hasta septiembre en\nel hemisferio norte, tiempo que coincide con una mayor duracién del dia, crecimiento del grass y clima\namigable. Las yeguas son poliéstricas estacionales. El principal factor que regula la estacionalidad es el\nfotoperiodo. La melatonina es una hormona pineal producida durante las horas de oscuridad, su patron\nde segregacion mimetizante de luz/oscuridad (y la respuesta Hipotalamo-hipofisaria) que ocurre cada 24h\nen el ciclo diurno, actua como un codificador diario de los cambios temporales en la duracién del dia y\nregula los ciclos de reproduccién por temporadas en mamiferos.\n\nLos animales perciben los cambios en la duracion diaria de la luz solar, lo que les indica la época del afio\nen la que se encuentran. Para ello, la sefial luminosa es transformada en sefiales endocrinas por medio\nde la glandula pineal, que interactua con el hipotalamo, la hipofisis y las gonadas, para regular las etapas\nde Ia fisiologia reproductiva. La actividad ovarica aumenta conforme se incrementan las horas luz.\n\nSe volvid una practica estandar industrial el extender la duracién del dia por 8-10 dias exponiendo a las\nhembras a luz artificial hasta las 11 horas, permitiendo el amanecer natural ocurrir durante la fase mas\nsensible del ciclo de 24 horas. Un fotoperiodo artificial de 16 horas: 8h de oscuridad es facilitado utilizando\nla luz de un bombillo de 3.6x3.6m de 100W de energia sueltamente descrito como “suficiente luz para leer\nun periédico”. Una terapia de luz como esta puede avanzar la temporada de crianza hasta una extensién\nde 3 meses.\n\nEstudios recientes indican que la luz en el espectro visible de luz (465-472nm) es mas efectiva en la\ninhibicién de la melatonina pues la melanopsina es particularmente sensible a las luces azules, las cuales\nposeen una longitud de onda corta, de un diode led apuntado directamente a un solo ojo. Se apunta a\ndeterminar si a luz, en un tiempo calculado, de baja intensidad administrada a un solo ojo desde mascaras\nde luz en las hembras es tan efectiva como la manutencién en ambientes cerrados de luz blanca en el\navance de las temporadas de reproduccion de las hembras.\n\nAl igual que en otros animales que se reproducen estacionalmente, el fotoperiodo también es importante\npara la yegua prefiada. Se ha encontrado que la longitud de la gestacién disminuye a medida que la\ntemporada de cria avanza y la duracién de la luz del dia es mas larga. De los estudios se informé un\nacortamiento significativo de la duracién de la gestacion y una tendencia de mayor peso al nacer del potto.\nLa luz administrada a la yegua prefiada puede modificar la tasa de maduracion del feto durante el trimestre\nfinal. El peso al nacer del potro es un factor importante para los criadores de caballos, ya que tiene\ninfluencia percibida en el caballo de ganancias potenciales y capacidad atlética futura. Los potros nacidos\nmas tarde en el afio (abril, mayo y junio), durante la temporada de reproduccién natural para el caballo,\ntienen pesos comparativamente mas altos que los potros nacidos en enero, febrero y marzo.\n\nVarios estudios han demostrado la eficacia de los programas de fotoperiodo artificial para adelantar el\ninicio de la estacion de actividad ovarica en yeguas en anestro estacional. En diferentes latitudes de\nambos hemisferios se han realizado estudios para evaluar diversos programas de fotoperiodo artificial\nenfocados a disminuir la duracién del periodo de transicion hacia la época reproductiva." + }, + { + "id": 60974, + "strid": "14c95a69-1ce0-4a4a-adac-e1db5aa5c453", + "image_id": 202907, + "image_name": "11943.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 399.273, + 1322.78, + 77.024, + 19.595000000000027 + ], + "priority": 7, + "parents": [ + 60994 + ], + "children": [ + 60981 + ], + "area": 528150.33894, + "iscrowd": 0, + "segmentation": [], + "text": "Objetivos" + }, + { + "id": 60981, + "strid": "5c0b6d98-f62e-427d-8830-076c9cbe4db2", + "image_id": 202907, + "image_name": "11943.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 77.254, + 1367.572, + 676.811, + 66.15100000000007 + ], + "priority": 8, + "parents": [ + 60974 + ], + "children": [], + "area": 105650.407288, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 60975, + "strid": "bd9b5a5c-68b5-4338-8bf4-550948a6b878", + "image_id": 202907, + "image_name": "11943.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 387.106, + 1455.557, + 101.26300000000003, + 20.202999999999975 + ], + "priority": 9, + "parents": [ + 60994 + ], + "children": [ + 60983, + 60984, + 60982 + ], + "area": 563454.848042, + "iscrowd": 0, + "segmentation": [], + "text": "Metodologia" + }, + { + "id": 60983, + "strid": "ae2e0af7-34ca-40df-a267-8e443f8e5bdb", + "image_id": 202907, + "image_name": "11943.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 81.877, + 1493.895, + 700.864, + 35.06099999999992 + ], + "priority": 10, + "parents": [ + 60975 + ], + "children": [], + "area": 122315.640915, + "iscrowd": 0, + "segmentation": [], + "text": "El desarrollo de la investigacion se lev de la siguiente manera: El proceso para seleccionar los estudios\npara su inclusién fue el siguiente:" + }, + { + "id": 60982, + "strid": "251de24c-c014-4936-9a3d-590d0b64ec38", + "image_id": 202907, + "image_name": "11943.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 82.021, + 1529.617, + 515.054, + 34.756000000000085 + ], + "priority": 11, + "parents": [ + 60975 + ], + "children": [], + "area": 125460.715957, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 60984, + "strid": "21bf7502-e8fd-4614-9550-86c546b8088b", + "image_id": 202907, + "image_name": "11943.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 81.727, + 1565.039, + 700.837, + 32.682000000000016 + ], + "priority": 12, + "parents": [ + 60975 + ], + "children": [], + "area": 127905.942353, + "iscrowd": 0, + "segmentation": [], + "text": "*Metodos generales para las revisiones Cochrane Capitulo 7: Seleccion de los estudios y obtencion de\nlos datos." + }, + { + "id": 60976, + "strid": "642e7a4a-219a-4ac9-a520-dc86de7239f6", + "image_id": 202907, + "image_name": "11943.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 365.177, + 1599.784, + 166.00300000000004, + 19.924999999999955 + ], + "priority": 13, + "parents": [ + 60994 + ], + "children": [ + 60992, + 60993, + 60990, + 60991, + 60986, + 60985, + 60987 + ], + "area": 584204.321768, + "iscrowd": 0, + "segmentation": [], + "text": "Revision Estratégica" + }, + { + "id": 60985, + "strid": "c50a011d-561e-403a-b26d-94a047c2ce3f", + "image_id": 202907, + "image_name": "11943.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 81.934, + 1641.9, + 542.515, + 301.4850000000001 + ], + "priority": 14, + "parents": [ + 60976 + ], + "children": [], + "area": 134527.4346, + "iscrowd": 0, + "segmentation": [], + "text": "EI desarrollo de la investigacion se llevé de la siguiente manera:\nEstudio 1\n\nSe dividié a las yeguas entre 5 y 24 afios aleatoriamente en tres grupos. En el\nprimer grupo n=16 fueron ubicadas en habitaciones iluminadas desde las 16:30\nh hasta las 23:00 h a una intensidad de 2050 lux. En el segundo grupo n=25 las\nyeguas recibieron la iluminacin de luz azul en un solo ojo mediante una\nmascara desde las 16:30 h hasta las 23:00 h, con una intensidad de 50 lux. El\ntercer grupo, n=19 solo fue puesto a prueba con luz natural.\n\nSe evaluaron a todos los grupos cada 2 semanas mediante ultrasonidos (para\nevaluar el tamafio del foliculo, presencia de cuerpo luteo, tono cervical, etc),\nrevisiones oftalmicas, evaluaciones de caida de pelaje y andlisis sanguineos\npara evaluar los niveles de progesterona.\n\nLos porcentajes iniciales de yeguas ciclando (en estro) fueron de 56% para el\ngrupo 1, 32% para el grupo 2 y 26% para el grupo 3. Estos resultados luego de" + }, + { + "id": 60986, + "strid": "fa1fa0ed-8c0b-44f8-b4b2-8ebc1cc5a339", + "image_id": 202907, + "image_name": "11943.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 82.184, + 1943.717, + 718.943, + 89.59400000000005 + ], + "priority": 15, + "parents": [ + 60976 + ], + "children": [], + "area": 159742.437928, + "iscrowd": 0, + "segmentation": [], + "text": "aplicar la luz artificial durante 4 meses variaron a 88%, 80% y 21% respectivamente.\nEn cuanto a las evaluaciones de progesterona el grupo 1 el nivel promedio del suero de progesterona\nfue significativamente mayor en las hembras estro, comparado con las que no lo estan. Las revisiones\noftalmicas no dan sefiales de algiin tipo de dafio o repercusion en la vision de las yeguas. La pérdida del\npelaje en ambos grupos es moderada." + }, + { + "id": 60987, + "strid": "c4551e41-8372-4ef6-a2a4-758765cb3039", + "image_id": 202907, + "image_name": "11943.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 634.261, + 1637.564, + 143.22399999999993, + 290.999 + ], + "priority": 16, + "parents": [ + 60976 + ], + "children": [], + "area": 1038642.980204, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 60993, + "strid": "8716127a-a0fa-4f25-89b9-14a98a5896e2", + "image_id": 202907, + "image_name": "11943.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 969.904, + 358.696, + 463.60799999999995, + 177.88099999999997 + ], + "priority": 17, + "parents": [ + 60976 + ], + "children": [], + "area": 347900.685184, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 60992, + "strid": "d2fae526-aede-4c15-978a-865660b68dab", + "image_id": 202907, + "image_name": "11943.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 842.27, + 538.439, + 722.7559999999999, + 386.98699999999997 + ], + "priority": 18, + "parents": [ + 60976 + ], + "children": [], + "area": 453511.01652999996, + "iscrowd": 0, + "segmentation": [], + "text": "Estudio 2\n\nSe separaron a las yeguas prefiadas por el mismo macho en dos grupos. El grupo A contara con una\nmascara que proporciona 50 lux azul a un solo ojo desde el atardecer hasta las 11 de la noche y se ira\naumentando gradualmente hasta proporcionar 16h de luz. El grupo B mantendra un fotoperiodo natural.\nTodas las yeguas se mantuvieron en potreros al aire libre con acceso a agua y comida.\n\nLongitud de gestacion\n\nEl grupo A tuvo una duracién media de gestacion de 334,6 + 9 dias. El grupo B tuvo una media de gestacion\nde 47,8 + 9 dias. Una diferencia media de 13,2 « 5 dias entre los grupos.\n\nPeso del potro al nacer\n\nEl peso medio al nacer del grupo A fue de 47,13 4 kg. El peso medio al nacer del grupo B fue 43,51 + 4\nkg. Esto representaba una diferencia media de 3,64 1,77 kg.\n\nInfluencia del fotoperiodo en el pelo del potro\n\nEl peso medio del pelo del grupo A y grupo B fue de 0,34 + 0,2 y 0,59 + 0,2 mg, respectivamente. El largo\ndel pelo fue de 1,93 + 0,56 en el grupo A y 2,56 + 0,56 en el grupo B.\n\nEl fotoperiodo provoca la supresion de la melatonina, una de las pocas hormonas maternas que cruzan la\nplacenta, esto da lugar a niveles mas elevados de prolactina materna, hormona que tiene un papel\nimportante durante la etapa de catagena (fase de transicién en el ciclo de crecimiento del cabello durante\nel cual se detiene el crecimiento). La prolactina ingresa a la circulacion fetal y se unen a sus receptores.\nputativos para inhibir el crecimiento del foliculo piloso. De esta manera, el aumento de los niveles de\nproduccién de prolactina materna se transmite potencialmente al feto en desarrollo. Esto, a su vez, entrega\nun mensaje de la época del afio que permite que el feto se desarrolle con una densidad de cabello reducida\nen prevision de un clima de verano mas calido." + }, + { + "id": 60990, + "strid": "6fd2c66a-ca6a-46a2-802d-87f578c2c640", + "image_id": 202907, + "image_name": "11943.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 865.081, + 937.354, + 673.4620000000001, + 410.11699999999996 + ], + "priority": 19, + "parents": [ + 60976 + ], + "children": [], + "area": 810887.135674, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 60991, + "strid": "8368da31-0edd-4fb3-8b9f-29d9937b1149", + "image_id": 202907, + "image_name": "11943.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 842.898, + 1351.859, + 660.4539999999998, + 19.50999999999999 + ], + "priority": 20, + "parents": [ + 60976 + ], + "children": [], + "area": 1139479.2473819999, + "iscrowd": 0, + "segmentation": [], + "text": "Se puede apreciar la diferencia entre el cabello de los potros con luz artificial (A) y luz natural (B)." + }, + { + "id": 60978, + "strid": "a730af28-cc2d-4c3e-8085-93d7a47db489", + "image_id": 202907, + "image_name": "11943.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1152.532, + 1387.051, + 111.36200000000008, + 17.15000000000009 + ], + "priority": 21, + "parents": [ + 60994 + ], + "children": [ + 60989 + ], + "area": 1598620.6631319998, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusiones" + }, + { + "id": 60989, + "strid": "64d60f82-e7dc-454b-b91e-157c7cf2bb51", + "image_id": 202907, + "image_name": "11943.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 840.741, + 1431.275, + 723.077, + 125.32999999999993 + ], + "priority": 22, + "parents": [ + 60978 + ], + "children": [], + "area": 1203331.574775, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 60977, + "strid": "34180a16-87d3-41a1-bc3a-fbcb09809cad", + "image_id": 202907, + "image_name": "11943.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1157.457, + 1572.882, + 94.827, + 16.94100000000003 + ], + "priority": 23, + "parents": [ + 60994 + ], + "children": [ + 60988 + ], + "area": 1820543.2810740003, + "iscrowd": 0, + "segmentation": [], + "text": "Referencias" + }, + { + "id": 60988, + "strid": "fb6d6954-6d93-42f1-a752-e1fd39729e31", + "image_id": 202907, + "image_name": "11943.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 842.362, + 1618.073, + 722.285, + 210.356 + ], + "priority": 24, + "parents": [ + 60977 + ], + "children": [], + "area": 1363003.208426, + "iscrowd": 0, + "segmentation": [], + "text": "Higgins, J. P. T., & Green, S. (2011). Manual Cochrane de revisiones sistematicas de intervenciones.\nCochrane, (March), 1-639. https://doi.org/Available from www.cochrane-handbook.org.\n\nMaria, L., Pérez, L., Quintero, L. Z., Myriam, A., & Acosta, B. (2010). Luna Maria Lopez Pérez\" Luis Zarco\nQuintero* Ana Myriam Boeta Acosta’, 41(2), 89-100.\n\nMurphy, B. A., Walsh, C. M., Woodward, E. M., Prendergast, R. L., Ryle, J. P., Fallon, L. H., & Troedsson,\nMH. T. (2014). Blue light from individual light masks directed at a single eye advances the breeding\nseason in mares. Equine Veterinary Journal, 46(5), 601-605. https://doi.org/10.1111/evj. 12153\n\nNolan, M. B., Walsh, C. M., Duff, N., MeCrarren, C., Prendergast, R. L., & Murphy, B. A. (2017). Artificially\nextended photoperiod administered to pre-partum mares via blue light to a single eye: Observations\non gestation length, foal birth weight and foal hair coat at birth. Theriogenology, 100, 126-133.\nhttps://doi.org/10.1016/.theriogenology.2017.06.012" + }, + { + "id": 48860, + "strid": "a8231167-ef80-4340-950b-97c21e4d9d93", + "image_id": 202413, + "image_name": "118667.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 20.49, + 39.35, + 134.41, + 179.21 + ], + "priority": -1, + "parents": [], + "children": [ + 48833, + 48830, + 48835, + 48832, + 48834, + 48831, + 48829 + ], + "area": 806.2814999999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 48829, + "strid": "3ce4be11-79f0-4e40-9fde-c6d5dd8e690a", + "image_id": 202413, + "image_name": "118667.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 178.546, + 77.296, + 1795.704, + 193.89600000000002 + ], + "priority": 1, + "parents": [ + 48860 + ], + "children": [], + "area": 13800.891616, + "iscrowd": 0, + "segmentation": [], + "text": "if)\n\nfla | / 1) /\n\nLo YEE} | X /\nMTT pe Ne ey\nTLL\n\nMILT TET TTL LTT TLL TL LTT)\n\nTIONWIDE ee cp i" + }, + { + "id": 48830, + "strid": "33bc12fe-15c5-45c7-8dd0-b2e6a884052c", + "image_id": 202413, + "image_name": "118667.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 181.633, + 361.641, + 2457.183, + 156.08099999999996 + ], + "priority": 2, + "parents": [ + 48860 + ], + "children": [], + "area": 65685.93975300001, + "iscrowd": 0, + "segmentation": [], + "text": "‘Jennifer Cogan ?Naveen‘Eipe »> °Grisell Vargas-Schaffer >» ‘Sylvain Belisle >» *Marie-France Ouimette\n\n‘Department of Anesthesia, Montreal Heart/Institute, Université de Montréal, Montréal QC,Canada - 7Department of Anesthesia, Ottawa Hospital, Ottawa University, Ottawa-ON»Canada\n’Pain Center of Hétel-Dieu du CHUM, Université de Montréal, Montréal QC, Canada“Department of Nursing, Montreal Heart.[nstitute, Université de Montréal, MontréalQC;-€anada" + }, + { + "id": 48831, + "strid": "615c01ed-2f05-4008-aa5b-8bcdf3d5315c", + "image_id": 202413, + "image_name": "118667.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 124.664, + 614.058, + 249.257, + 40.298 + ], + "priority": 3, + "parents": [ + 48860 + ], + "children": [ + 48836 + ], + "area": 76550.926512, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 48836, + "strid": "b7668f9a-4d41-4f39-8f6a-17291e55c783", + "image_id": 202413, + "image_name": "118667.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 63.896, + 680.713, + 371.851, + 276.293 + ], + "priority": 4, + "parents": [ + 48831 + ], + "children": [], + "area": 43494.837847999996, + "iscrowd": 0, + "segmentation": [], + "text": "Acute Pain Services (APS) have been well\nestablished in Canada and their services\nimprove the management of postopera-\ntive pain. The availability and use of APS in\ncardiac surgery units however is less wide-\nspread and even where present may be\nprovided less consistently. We undertook\nthe first nationwide survey irom Canada\nto assess the current clinical practice of\npain management after cardiac surgery." + }, + { + "id": 48832, + "strid": "6cc3f45a-8795-4979-bc46-3bd870b83c5c", + "image_id": 202413, + "image_name": "118667.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 124.356, + 1003.873, + 186.06399999999996, + 40.057000000000016 + ], + "priority": 5, + "parents": [ + 48860 + ], + "children": [ + 48837 + ], + "area": 124837.630788, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 48837, + "strid": "5a4528da-a1e5-43c5-9385-5289fbe62382", + "image_id": 202413, + "image_name": "118667.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 64.165, + 1070.425, + 372.238, + 327.799 + ], + "priority": 6, + "parents": [ + 48832 + ], + "children": [], + "area": 68683.820125, + "iscrowd": 0, + "segmentation": [], + "text": "The Survey was approved by the IRB (ICM-\n12-1350). The questionnaire was drafted by\niwo anesthesiologists working in pain man-\nagement and reviewed for content validity\nby a domain specialist. The twenty items that\nwere retained covered structure, functioning\nand demographics of the pain services. A list\nof all the national centers performing adult\ncardiac surgery in Canada was drafted and\ntheir lead anesthesiologists identified by\ndirect contact. The survey questionnaire was\nthen sent electronically and results collected." + }, + { + "id": 48833, + "strid": "b58878b1-a68a-4705-93cc-5644fa3194d6", + "image_id": 202413, + "image_name": "118667.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 114.605, + 1517.177, + 194.675, + 47.346000000000004 + ], + "priority": 7, + "parents": [ + 48860 + ], + "children": [ + 48838 + ], + "area": 173876.07008499998, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 48838, + "strid": "0b1239ee-7b9b-4b26-ba04-8232f766c60c", + "image_id": 202413, + "image_name": "118667.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 63.03, + 1599.961, + 373.783, + 569.9269999999999 + ], + "priority": 8, + "parents": [ + 48833 + ], + "children": [], + "area": 100845.54183, + "iscrowd": 0, + "segmentation": [], + "text": "We received completed question-\nnaires=.from all 32 centers and\nachieved/a response rate of 100%.\nOf ‘the centers poled 53% had an\nacute pain service, 25% did not and\n15% had various other combinations.\nOf those who answered the question\n47% had been functioning for more.\nthan 5 years, 11% for 2 to 5 years and\n23% for less than 2 years. In terms of\nTee Sem SCE UPL)\nonly, 27% were nurse run only and\nULMER ML ECM OFLC) Bove\n16 number of centers expressed in-\nterest in developing, working group\nand proposing. consensus guidelines.\nfor the standardization of acute pain\nmanagement after cardiac surgery." + }, + { + "id": 48835, + "strid": "6ab4a1bc-3eee-4512-8cce-7045e4e8d18c", + "image_id": 202413, + "image_name": "118667.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 703.759, + 586.266, + 1214.078, + 48.57299999999998 + ], + "priority": 9, + "parents": [ + 48860 + ], + "children": [ + 48855, + 48844, + 48847, + 48854, + 48840, + 48845, + 48851, + 48842, + 48843, + 48859, + 48853, + 48846, + 48849, + 48857, + 48850, + 48848, + 48856, + 48858, + 48852, + 48841 + ], + "area": 412589.973894, + "iscrowd": 0, + "segmentation": [], + "text": "Structure and Functioning of your Cardiac Surgefy.Center" + }, + { + "id": 48840, + "strid": "e3a9785d-1290-431d-9638-bb03c7be33ad", + "image_id": 202413, + 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+ "segmentation": [] + }, + { + "id": 48843, + "strid": "69ff6989-7527-4ce2-9d24-0aa899add105", + "image_id": 202413, + "image_name": "118667.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 532.074, + 1624.163, + 506.96899999999994, + 143.8499999999999 + ], + "priority": 13, + "parents": [ + 48835 + ], + "children": [], + "area": 864174.904062, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 48844, + "strid": "85ac8689-d2ad-4fae-99a7-a9b0066b325e", + "image_id": 202413, + "image_name": "118667.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 533.078, + 1800.956, + 506.3029999999999, + 143.45800000000008 + ], + "priority": 14, + "parents": [ + 48835 + ], + "children": [], + "area": 960050.0225679999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 48845, + "strid": "81e6fff9-a395-4961-9192-2deee177672b", + "image_id": 202413, + "image_name": "118667.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 532.588, + 1980.508, 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513.4680000000001 + ], + "priority": 28, + "parents": [ + 48835 + ], + "children": [], + "area": 2536390.369432, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 48859, + "strid": "ee910f6c-6324-48bb-bac6-8e2b8ec3d2a8", + "image_id": 202413, + "image_name": "118667.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2207.753, + 669.799, + 545.7469999999998, + 546.675 + ], + "priority": 29, + "parents": [ + 48835 + ], + "children": [], + "area": 1478750.751647, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 48834, + "strid": "57d2916e-aaad-4f88-9f3c-c55511982891", + "image_id": 202413, + "image_name": "118667.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2283.88, + 1379.174, + 278.0140000000001, + 49.846000000000004 + ], + "priority": 30, + "parents": [ + 48860 + ], + "children": [ + 48839 + ], + "area": 3149867.91512, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion" + }, + { + "id": 48839, + "strid": "cd914c00-0b2c-4066-9428-00032848beab", + "image_id": 202413, + "image_name": "118667.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2282.597, + 1464.444, + 460.9380000000001, + 548.364 + ], + "priority": 31, + "parents": [ + 48834 + ], + "children": [], + "area": 3342735.481068, + "iscrowd": 0, + "segmentation": [], + "text": "PCLT era este AU Ceeham Lm Orla Colca mere Ug Es Commerc)\nCeCe UCMN EU LO LIM MLL CME-UCe LUT Ce\nONY AEE MLCT CUCL SS Uc\nare sites. In general pain management is a\nprotocol driven activity.\n\nFurther identification of patients at risk, surgi-\ncal procedures with severe acute neuropathic\npain.or chronic post-surgical pain and thera-\npeutic modalities with proven benefit in the\nnon-cardiac surgical population; may improve\nUCM UCR MUTI CCU SMO lM ML CCIEMIIe IKE (IIT)\ncardiac surgical procedures.\n\nThe development and standardization, of\nCardiac Acute Pain Services will be important\nto achieve these and the findings of this Survey\nprovide useful first steps in this.direction." + }, + { + "id": 97398, + "strid": "f16d1b39-0a3e-431e-aed8-df2f4674f922", + "image_id": 204268, + "image_name": "121755.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 69.95, + 64.05, + 117.33, + 167.62 + ], + "priority": -1, + "parents": [], + "children": [ + 97375, + 97376, + 97378, + 97380, + 97379, + 97381, + 97377 + ], + "area": 4480.2975, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 97375, + "strid": "1bdfe277-0700-4a56-a98f-7a51de423d5b", + "image_id": 204268, + "image_name": "121755.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 346.117, + 46.099, + 2656.808, + 182.857 + ], + "priority": 1, + "parents": [ + 97398 + ], + "children": [], + "area": 15955.647583, + "iscrowd": 0, + "segmentation": [], + "text": "TRE EFFECT OF ABATACEPT THERAPY ON GRANZYME B SERUM LEVELS\nIN PATIENTS WITH RHEUMATOID ARTHRITIS" + }, + { + "id": 97376, + "strid": "cea44bcb-338e-437c-95df-9eb5fc3f2e4b", + "image_id": 204268, + "image_name": "121755.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 883.81, + 277.979, + 1579.732, + 271.90400000000005 + ], + "priority": 2, + "parents": [ + 97398 + ], + "children": [], + "area": 245680.61998999998, + "iscrowd": 0, + "segmentation": [], + "text": "Piantoni S!2?, Colombo E?, Scarsi M1, Tincani A??, Aird P?\n\n1.Rheumatology and Clinical Immunology, Spedali Civili of Brescia, Brescia;\n2.Rheumatology Chair, University of Pavia, Pavia;\n3. Department of Clinical and Experimental Sciences, University of Brescia, Brescia.\nITALY" + }, + { + "id": 97377, + "strid": "91096118-f6fb-43d5-a969-2f428842e143", + "image_id": 204268, + "image_name": "121755.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1528.964, + 576.692, + 280.37699999999995, + 36.124000000000024 + ], + "priority": 3, + "parents": [ + 97398 + ], + "children": [ + 97386, + 97387, + 97389, + 97388 + ], + "area": 881741.307088, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 97386, + "strid": "44eefdae-21f8-44df-8715-01bb95b0c348", + "image_id": 204268, + "image_name": "121755.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 100.406, + 662.409, + 2029.011, + 934.572 + ], + "priority": 4, + "parents": [ + 97377 + ], + "children": [], + "area": 66509.838054, + "iscrowd": 0, + "segmentation": [], + "text": "of serine proteases which play key roles in the induction of target cell death\nby cytotoxic T-lymphocytes and NK cells.\n\n \n \n \n \n \n \n\nexpressed by activated CD4+ and CD8+ T-cells, while it less abundant in NK cells (1).\n\nuble GZMB levels are elevated in the sera of patients with rheumatoid\nRA) (2), and are associated with early development of radiographic erosions (3).\n\n‘ole of GZMB in the pathogenesis of joint damage was suggested by in vitro data demonstrating\nymatic activity for the cleavage of cartilage aggrecan proteoglycans and by the associations\nof a genetic variant of GZMB with progression of joint destruction (4).\n\n \n \n \n\n \n \n\n \n\nA is characterized by several changes of the T-cell compartment which include, in most patients,\nan increased number of T-cells lacking the CD28 costimulatory molecule, which display\nsome functional characteristic of cytotoxic memory T-cells (including expression of granzymes) (5).\n\n \n \n \n\n \n\nAbatacept (ABA) is a CTLA 4-lg fusion molecule efficacious in RA treatment.\n\nMany of the biological actions of ABA are likely to be an indirect consequence of the blockade of the CD28-T-cell\nco-stimulatory signals necessary for the full activation of T-cells." + }, + { + "id": 97389, + "strid": "4d9d46c0-c22b-456b-ac2d-baa97086fbcd", + "image_id": 204268, + "image_name": "121755.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2225.604, + 642.655, + 1107.475, + 877.146 + ], + "priority": 5, + "parents": [ + 97377 + ], + "children": [], + "area": 1430295.5386199998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 97388, + "strid": "781f2803-bc60-4959-b7b4-6905b99167c2", + "image_id": 204268, + "image_name": "121755.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2469.573, + 1540.193, + 619.645, + 54.743999999999915 + ], + "priority": 6, + "parents": [ + 97377 + ], + "children": [], + "area": 3803619.047589, + "iscrowd": 0, + "segmentation": [], + "text": "Image from Boivin WA, et al. Laboratory Investigation (2009).\nClassical granzyme B-mediated apoptosis pathway." + }, + { + "id": 97387, + "strid": "9fde9c5b-1e3b-4b59-9e71-416696916ba7", + "image_id": 204268, + "image_name": "121755.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 280.78, + 1636.864, + 2786.9390000000003, + 100.721 + ], + "priority": 7, + "parents": [ + 97377 + ], + "children": [], + "area": 459598.67392, + "iscrowd": 0, + "segmentation": [], + "text": "Since CD28 negative (CD28-) T-cells may be‘ah important source of GZMB, and we have previously shown that co-stimulation blockade by ABA\ncan prevent the generation of the CD28- T-cell populations (6), we evaluated the effect of abatacept therapy on GZMB serum levels in patients, with-RA." + }, + { + "id": 97378, + "strid": "2c524bd3-3027-42d7-99d5-6b73604a2e8f", + "image_id": 204268, + "image_name": "121755.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1570.328, + 1791.884, + 201.36300000000006, + 32.718000000000075 + ], + "priority": 8, + "parents": [ + 97398 + ], + "children": [ + 97392, + 97385 + ], + "area": 2813845.617952, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 97385, + "strid": "71bea928-4fb3-4736-ab40-9aeb8f1a5dd4", + "image_id": 204268, + "image_name": "121755.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 32.871, + 1881.195, + 1137.039, + 741.9469999999999 + ], + "priority": 9, + "parents": [ + 97378 + ], + "children": [], + "area": 61836.760845000004, + "iscrowd": 0, + "segmentation": [], + "text": "Fifty-three RA patients, treated for at least 3 months with ABA\nwere evaluated (Table 1.).\n\nDisease activity and response to the treatment were measured\nwith DAS28 (based on CRP) and EULAR Criteria.\n\nT-cell counts were determined by flow cytometry.\nSerum GZMB samples were collected before the first\nadministration of abatacept (TO) in the entire cohort of\npatients, and then after 6 months (T6) in 25 subjects.\n\nGZMB serum levels were measured by an indirect\nsolid-phase enzyme immunoassay with\na sensitivity limit of 20 pg/ml." + }, + { + "id": 97392, + "strid": "2f29336d-1234-4bce-b5f0-063f5d1720df", + "image_id": 204268, + "image_name": "121755.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1214.233, + 1859.768, + 2108.251, + 715.5929999999998 + ], + "priority": 10, + "parents": [ + 97378 + ], + "children": [ + 97394 + ], + "area": 2258191.677944, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 97394, + "strid": "af7dd974-9d23-471c-9a58-974fcc226018", + "image_id": 204268, + "image_name": "121755.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1347.573, + 2588.928, + 1840.47, + 75.81899999999996 + ], + "priority": 11, + "parents": [ + 97392 + ], + "children": [], + "area": 3488769.471744, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1. Main clinical and demographic features of RA patients. Data are expressed as the median [10th-90th percentile], if not otherwise indicated.\nNo differences in ‘al and demographic features between the two groups of patients (n=53 vs. n=25) (Chi-square/Fisher test and Mann-Whitney test; a p value < 0.05 was considered to be significant).\nCCP: cyclic citrullinated peptide; DMARDs: disease modifying anti-rheumatic drugs: ABA: abatacept; TNF: tumor necrosis factor; DAS= disease activity score; CRP: C-reactive protein." + }, + { + "id": 97379, + "strid": "bff5117e-b97d-41dd-a515-5d386067bec9", + "image_id": 204268, + "image_name": "121755.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1587.681, + 2712.866, + 166.33500000000004, + 34.11299999999983 + ], + "priority": 12, + "parents": [ + 97398 + ], + "children": [ + 97384, + 97390, + 97391, + 97393 + ], + "area": 4307165.803746, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 97384, + "strid": "a9a51203-4c4a-4cfd-a8fd-6e6e3726ea8b", + "image_id": 204268, + "image_name": "121755.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 65.921, + 2919.324, + 1068.582, + 1325.1520000000005 + ], + "priority": 13, + "parents": [ + 97379 + ], + "children": [], + "area": 192444.75740400003, + "iscrowd": 0, + "segmentation": [], + "text": "The percentage and the absolute number of circulating\nCD4+CD28- T-cells decreased after ABA therapy\n(TO vs. T6: p=0.018; p=0.018, respectively), as well as those\nof CD8+CD28- T-cells (p=0.005; p=0.008) (Table 2.).\n\nAt TO, GZMB serum levels were correlated with\npercentages of circulating CD4+CD28-\nand CD8+CD28- T-cells (p=0.007; p=0.030) and with\ndisease activity (p=0.002) (Figure 1.).\n\nIn 25 patients serum levels of GZMB were evaluated also\nat T6: in 18 patients with a moderate or\ngood clinical response to abatacept the levels of GZMB\nsignificantly decreased from TO\n(median: 62.8 pg/ml [10th-90th percentile: 45.8-116]) to\nT6 (53.8 pg/ml [46.4-96.6]; p=0.023), whereas no\nvariation was observed in 7 non-responders (Figure 2a.).\n\nThe variation of GZMB levels was directly correlated with\nthat of DAS28-CRP (p=0.040) (Figure 2b.), but not with\nthose of circulating CD28- T-cell subsets (data not shown)." + }, + { + "id": 97390, + "strid": "691b142f-a00a-4142-bd04-98a26f90ed67", + "image_id": 204268, + "image_name": "121755.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1216.211, + 2782.395, + 1226.655, + 1565.0390000000002 + ], + "priority": 14, + "parents": [ + 97379 + ], + "children": [ + 97395 + ], + "area": 3383979.405345, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 97395, + "strid": "a3f3bf76-e2de-4bcd-9710-8257cf5b8a7e", + "image_id": 204268, + "image_name": "121755.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1249.825, + 4358.071, + 1160.999, + 78.14000000000033 + ], + "priority": 15, + "parents": [ + 97390 + ], + "children": [], + "area": 5446826.087575, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. Correlations of serum levels of Granzyme B (GZMB) with the percentages of CD4+CD28- (a.), CD8+CD28- (b.) T-cells and\nDAS28-CRP (c.) at baseline (Linear simple regression ; a p value < 0.05 was considered to be significant).\nDAS= disease activity score; CRP: C-reactive protein." + }, + { + "id": 97393, + "strid": "bf195ff1-ecda-4390-9ba7-b8b5a593ccf1", + "image_id": 204268, + "image_name": "121755.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2458.045, + 2852.477, + 863.1289999999999, + 435.86400000000003 + ], + "priority": 16, + "parents": [ + 97379 + ], + "children": [ + 97397 + ], + "area": 7011516.827465, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 97397, + "strid": "7c5df5c4-d402-42ff-a8a5-ad883b6111db", + "image_id": 204268, + "image_name": "121755.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2505.877, + 3305.174, + 767.9900000000002, + 75.66699999999992 + ], + "priority": 17, + "parents": [ + 97393 + ], + "children": [], + "area": 8282359.507598, + "iscrowd": 0, + "segmentation": [], + "text": "Table 2. Variations of T-cell subpopulations after 6 months of therapy with abatacept\n(Wilcoxon signed-rank test; a p value < 0.05 was considered to be significant).\nData are expressed as the median [10th-90th percentile]." + }, + { + "id": 97391, + "strid": "87ab19ff-696b-441b-910b-d02321d99a8b", + "image_id": 204268, + "image_name": "121755.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2471.292, + 3417.011, + 854.6730000000002, + 820.5970000000002 + ], + "priority": 18, + "parents": [ + 97379 + ], + "children": [ + 97396 + ], + "area": 8444431.948212, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 97396, + "strid": "8e6bf85c-f583-484d-bd74-396146d07c31", + "image_id": 204268, + "image_name": "121755.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2491.825, + 4249.255, + 812.44, + 130.65899999999965 + ], + "priority": 19, + "parents": [ + 97391 + ], + "children": [], + "area": 10588399.840374999, + "iscrowd": 0, + "segmentation": [], + "text": "‘igure 2. Variations of granzyme B (GZMB) serum levels in patients treated with abatacept\nfor 6 months (a.) (Wilcoxon signed-rank test; a p value < 0.05 was considered to be\nsignificant). Correlation of variations of granzyme B serum levels. 27d DAS28-CRP in\n\npatients treated with abatacept for 6 months (b.) (Linear siniole regression;\na p value < 0.05 was considered to be significant)." + }, + { + "id": 97380, + "strid": "9f3025a2-1b19-466e-bc9c-6782df42b83e", + "image_id": 204268, + "image_name": "121755.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 867.815, + 4481.645, + 280.154, + 33.126000000000204 + ], + "priority": 20, + "parents": [ + 97398 + ], + "children": [ + 97383 + ], + "area": 3889238.7556750006, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 97383, + "strid": "36575556-4624-4382-adc8-5e190d5f114f", + "image_id": 204268, + "image_name": "121755.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 156.057, + 4565.18, + 1702.056, + 257.9489999999996 + ], + "priority": 21, + "parents": [ + 97380 + ], + "children": [], + "area": 712428.29526, + "iscrowd": 0, + "segmentation": [], + "text": "Costimulation blockade by abatacept can decrease the serum levels of GZMB in RA patients\nresponding to the treatment, suggesting that this might be one of the mechanism by which\nabatacept could\\prévent radiographic erosions.\n\nHowever, the lack of correlation of such decrease with the numbers\nof circulating CD28- T-cells suggests that these cells are not the main source of serunvGZMB." + }, + { + "id": 97381, + "strid": "c7291d0b-9cc5-4d8e-b210-7fe17d1d7e1f", + "image_id": 204268, + "image_name": "121755.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2549.796, + 4481.566, + 242.70199999999977, + 33.77800000000025 + ], + "priority": 22, + "parents": [ + 97398 + ], + "children": [ + 97382 + ], + "area": 11427079.060535999, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 97382, + "strid": "42721bf7-2dc9-46e5-85e8-b1257969e2ae", + "image_id": 204268, + "image_name": "121755.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2120.695, + 4550.539, + 985.6390000000001, + 279.78700000000026 + ], + "priority": 23, + "parents": [ + 97381 + ], + "children": [], + "area": 9650305.304605, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 36577, + "strid": "aefba424-011d-472d-a95e-3c21aa454fcf", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 38.45, + 25.89, + 325.45, + 77.22 + ], + "priority": -1, + "parents": [], + "children": [ + 36544, + 36545, + 36543, + 36541, + 36554, + 36539, + 36540, + 36542 + ], + "area": 995.4705000000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 36539, + "strid": "b824b675-8ba5-4bb6-b901-f854e72df1a9", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 894.022, + 59.082, + 3209.285, + 271.124 + ], + "priority": 1, + "parents": [ + 36577 + ], + "children": [], + "area": 52820.60780400001, + "iscrowd": 0, + "segmentation": [], + "text": "Modeling Raccoon Removals and Recolonization of Woodlots\nUsing Animal Dispersal Model SEARCH" + }, + { + "id": 36540, + "strid": "1610b004-9c4d-49f8-9fce-7a215ec3530c", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 931.84, + 345.357, + 3139.438, + 216.73399999999998 + ], + "priority": 2, + "parents": [ + 36577 + ], + "children": [], + "area": 321817.46688, + "iscrowd": 0, + "segmentation": [], + "text": "Alexander J. Cohen [1], Benjamin P. Pauli [1], Patrick A. Zollner [1], James C. Beasley [2], Olin E. Rhodes, Jr. [2]\n[1] Purdue University, Department of Forestry and Natural Resources, West Lafayette, IN 47907 USA, Contact: cohen10@purdue.edu\n[2] University of Georgia, Savannah River Ecology Lab, Aiken, SC 29802 USA" + }, + { + "id": 36541, + "strid": "f82194c1-5e0c-47ce-8daa-f8afd94702ca", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 560.554, + 612.526, + 373.92500000000007, + 72.86000000000001 + ], + "priority": 3, + "parents": [ + 36577 + ], + "children": [ + 36547, + 36548, + 36549, + 36552, + 36550, + 36546 + ], + "area": 343353.89940399997, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 36546, + "strid": "0ebfa13d-2e35-4c0a-96e3-32b5983067db", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 118.094, + 710.127, + 1231.11, + 531.261 + ], + "priority": 4, + "parents": [ + 36541 + ], + "children": [], + "area": 83861.73793799999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 36547, + "strid": "6d7683c9-e652-45e2-936d-901dd434553e", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 116.85, + 1302.157, + 1257.041, + 262.61300000000006 + ], + "priority": 5, + "parents": [ + 36541 + ], + "children": [], + "area": 152157.04544999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 36548, + "strid": "f42c335d-d1ff-4b33-9505-06b9cc09038b", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 116.756, + 1624.137, + 1234.295, + 260.1700000000001 + ], + "priority": 6, + "parents": [ + 36541 + ], + "children": [], + "area": 189627.739572, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 36549, + "strid": "8c09cadf-7fc8-482d-bfbd-160293d3b5c1", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 118.573, + 1941.786, + 1240.041, + 416.087 + ], + "priority": 7, + "parents": [ + 36541 + ], + "children": [], + "area": 230243.391378, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 36550, + "strid": "c36cf9c8-4c17-4e0c-9ec4-bb8f3c5d24e7", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 88.639, + 2442.278, + 693.423, + 540.1399999999999 + ], + "priority": 8, + "parents": [ + 36541 + ], + "children": [ + 36551 + ], + "area": 216481.07964199997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 36551, + "strid": "bc735fdc-0440-4bf8-b55e-c01c7279cd90", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 118.408, + 3027.215, + 545.651, + 109.13000000000011 + ], + "priority": 9, + "parents": [ + 36550 + ], + "children": [], + "area": 358446.47372, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. Map of the UWB within Indiana.\nThe shaded area is where field work and\nsubsequent modeling took place." + }, + { + "id": 36552, + "strid": "f16a301b-83e6-4e47-8cc1-b2356636c719", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 885.538, + 2432.949, + 474.595, + 630.299 + ], + "priority": 10, + "parents": [ + 36541 + ], + "children": [ + 36553 + ], + "area": 2154468.7915620003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 36553, + "strid": "7a166b80-db20-46eb-82b0-ae903c454ef2", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 942.465, + 3080.296, + 361.36199999999997, + 60.422000000000025 + ], + "priority": 11, + "parents": [ + 36552 + ], + "children": [], + "area": 2903071.16964, + "iscrowd": 0, + "segmentation": [], + "text": "Picture taken from\nhttp://bigbearzoo.org/raccoon/" + }, + { + "id": 36542, + "strid": "ebb96192-a1b5-45e6-8556-779f7bcd013f", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2051.191, + 616.482, + 264.009, + 61.264999999999986 + ], + "priority": 12, + "parents": [ + 36577 + ], + "children": [ + 36565, + 36563, + 36566, + 36557, + 36562, + 36556, + 36558, + 36559 + ], + "area": 1264522.3300619998, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 36556, + "strid": "af1e667b-52fb-4bac-acab-cad98910b618", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1555.766, + 710.565, + 599.0639999999999, + 41.06899999999996 + ], + "priority": 13, + "parents": [ + 36542 + ], + "children": [], + "area": 1105472.86779, + "iscrowd": 0, + "segmentation": [], + "text": "SEARCH Parameterization: Maps" + }, + { + "id": 36557, + "strid": "df255e1d-ba03-4fd2-b612-ef67d0cf5aec", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1556.184, + 768.687, + 1236.7789999999998, + 101.41600000000005 + ], + "priority": 14, + "parents": [ + 36542 + ], + "children": [], + "area": 1196218.410408, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 36558, + "strid": "7698d617-f547-4aca-8727-9961af9ff3b8", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1519.449, + 881.223, + 662.8490000000002, + 662.1860000000001 + ], + "priority": 15, + "parents": [ + 36542 + ], + "children": [ + 36561 + ], + "area": 1338973.406127, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 36561, + "strid": "35270017-1b5e-48d5-b023-ac6c07e34d00", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1640.619, + 1563.201, + 470.06600000000003, + 109.1110000000001 + ], + "priority": 16, + "parents": [ + 36558 + ], + "children": [], + "area": 2564617.261419, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2. Sample land cover map for\nfood, risk, and movement\nparameterization." + }, + { + "id": 36559, + "strid": "7ab2e85d-1d28-4126-a3b0-40fe83e17bbf", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2189.787, + 881.405, + 661.3980000000001, + 661.896 + ], + "priority": 17, + "parents": [ + 36542 + ], + "children": [ + 36560 + ], + "area": 1930089.2107349997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 36560, + "strid": "47242b10-51e0-4598-9f60-582037ccd8dc", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2254.475, + 1559.112, + 488.799, + 108.70299999999997 + ], + "priority": 18, + "parents": [ + 36559 + ], + "children": [], + "area": 3514979.0262, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3. Sample map representing\nhabitat suitability, with living resident\nraccoons present in the center area" + }, + { + "id": 36562, + "strid": "1b0a9b55-9031-429c-a5b0-350a4a99fc82", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1551.851, + 1729.627, + 1255.9249999999997, + 471.06799999999976 + ], + "priority": 19, + "parents": [ + 36542 + ], + "children": [], + "area": 2684123.389577, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 36563, + "strid": "656a8cc0-ef98-4344-a170-c4406921cdb9", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1556.368, + 2228.921, + 538.4290000000001, + 36.14800000000014 + ], + "priority": 20, + "parents": [ + 36542 + ], + "children": [], + "area": 3469021.3189279996, + "iscrowd": 0, + "segmentation": [], + "text": "Other Simulation Parameters" + }, + { + "id": 36565, + "strid": "3600652e-e956-444a-ae80-4568483a927c", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1610.443, + 2346.539, + 1141.608, + 414.547 + ], + "priority": 21, + "parents": [ + 36542 + ], + "children": [ + 36564 + ], + "area": 3778967.3067770004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 36564, + "strid": "38202151-87ed-4c09-b356-f5f03c526dfc", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1554.045, + 2293.868, + 1209.0900000000001, + 40.66199999999981 + ], + "priority": 22, + "parents": [ + 36565 + ], + "children": [], + "area": 3564774.09606, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1. A subset of parameters input into SEARCH to calibrate virtual raccoons." + }, + { + "id": 36566, + "strid": "e844296c-3aaf-49b5-a0a1-62dad9abbb00", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1552.987, + 2784.34, + 1180.315, + 364.53499999999985 + ], + "priority": 23, + "parents": [ + 36542 + ], + "children": [], + "area": 4324043.823580001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 36543, + "strid": "142542f5-9036-4b42-b715-c274af823181", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3514.669, + 617.549, + 210.82999999999993, + 60.64999999999998 + ], + "priority": 24, + "parents": [ + 36577 + ], + "children": [ + 36568, + 36567, + 36572, + 36569, + 36573 + ], + "area": 2170480.326281, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 36567, + "strid": "bbccd328-08b6-4cc7-bbc2-9b525721c12b", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2976.031, + 706.789, + 855.6869999999999, + 799.2659999999998 + ], + "priority": 25, + "parents": [ + 36543 + ], + "children": [], + "area": 2103425.974459, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 36568, + "strid": "fc89c539-7d12-4a35-84be-3308c9a5ad8b", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3886.814, + 650.82, + 738.6200000000003, + 341.27 + ], + "priority": 26, + "parents": [ + 36543 + ], + "children": [ + 36570 + ], + "area": 2529616.28748, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 36570, + "strid": "25cbc160-7d2e-4821-a63f-e34947467e9e", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 3817.063, + 1003.409, + 799.6040000000003, + 103.3359999999999 + ], + "priority": 27, + "parents": [ + 36568 + ], + "children": [], + "area": 3830075.367767, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 4. Comparison of mean weights of simulated raccoons\n(across all 13 patches) and actual raccoon mean weights from\nfield measurements." + }, + { + "id": 36569, + "strid": "624e3851-eb8a-49c9-96ff-b1bef9cfee3b", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3882.962, + 1122.953, + 738.0589999999997, + 388.10400000000004 + ], + "priority": 28, + "parents": [ + 36543 + ], + "children": [ + 36571 + ], + "area": 4360383.826786, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 36571, + "strid": "430cf874-e5cd-4e10-8f98-3e46317e537b", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 3824.109, + 1529.609, + 788.9000000000001, + 144.664 + ], + "priority": 29, + "parents": [ + 36569 + ], + "children": [], + "area": 5849391.543381, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 5. Difference between forest patch density estimates\nfor simulation runs and field values. A value above 0\n\nmeans the simulation overestimated densities, while a value\nunder O means the simulation underestimated densities." + }, + { + "id": 36572, + "strid": "1e4b6fa9-c0c4-4e21-bd0d-c350ae31048c", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2979.798, + 1642.062, + 1048.8829999999998, + 744.7829999999999 + ], + "priority": 30, + "parents": [ + 36543 + ], + "children": [], + "area": 4893013.063475999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 36573, + "strid": "ded6700c-5d4e-4028-ae48-f0b859093e3e", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3880.943, + 1831.908, + 746.1279999999997, + 426.12300000000005 + ], + "priority": 31, + "parents": [ + 36543 + ], + "children": [ + 36574 + ], + "area": 7109530.529244, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 36574, + "strid": "4880540a-92d3-4fd4-a78b-4f2cbf48e581", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 4006.896, + 2278.413, + 605.1860000000001, + 106.69799999999987 + ], + "priority": 32, + "parents": [ + 36573 + ], + "children": [], + "area": 9129363.936048001, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 6. Comparison of time to recolonization\nof 11 forest patches after raccoon removals\nin field experiments and in simulations." + }, + { + "id": 36544, + "strid": "b854c131-6b9a-4939-bc4d-095ec14119e4", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3654.756, + 2462.13, + 305.9279999999999, + 63.4670000000001 + ], + "priority": 33, + "parents": [ + 36577 + ], + "children": [ + 36575 + ], + "area": 8998484.39028, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion" + }, + { + "id": 36575, + "strid": "4b30bd46-5576-47bc-bb22-85f5ed1d849e", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2979.37, + 2534.087, + 1569.589, + 313.5239999999999 + ], + "priority": 34, + "parents": [ + 36544 + ], + "children": [], + "area": 7549982.785189999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 36545, + "strid": "37f45253-17f5-4652-8450-2edd508aa20c", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3555.369, + 2933.514, + 505.17599999999993, + 64.8119999999999 + ], + "priority": 35, + "parents": [ + 36577 + ], + "children": [ + 36576 + ], + "area": 10429724.736666001, + "iscrowd": 0, + "segmentation": [], + "text": "Future Directions" + }, + { + "id": 36576, + "strid": "1351ea15-e4e4-455d-923e-458ae9d66e29", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2980.706, + 3006.354, + 1622.3069999999998, + 365.9749999999999 + ], + "priority": 36, + "parents": [ + 36545 + ], + "children": [], + "area": 8961057.405924, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 36554, + "strid": "58ddd9b2-ff4a-40b2-bff4-5784ad5582b8", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 94.739, + 3246.798, + 206.08, + 36.190000000000055 + ], + "priority": 37, + "parents": [ + 36577 + ], + "children": [ + 36555 + ], + "area": 307598.395722, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 36555, + "strid": "71ee27bf-201f-4549-b316-5051a14fb086", + "image_id": 201943, + "image_name": "117912.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 92.861, + 3302.664, + 2590.949, + 72.32799999999997 + ], + "priority": 38, + "parents": [ + 36554 + ], + "children": [], + "area": 306688.68170400005, + "iscrowd": 0, + "segmentation": [], + "text": "Beasley JC, Olson ZH, Beatty WS, Dharmarajan G, Rhodes OE Jr (2013) Effects of Culling on Mesopredator Population Dynamics. PLoS ONE 8(3): e58982. doi:10.1371/journal.pone.0058982\nPauli BP, McCann NP, Zollner PA, Cummings R, Gilbert JH, et al. (2013) SEARCH: Spatially Explicit Animal Response to Composition of Habitat. PLoS ONE 8(5): e64656. doi:10.1371/journal.pone.0064656" + }, + { + "id": 164758, + "strid": "92ca01c7-685a-41e9-b1a0-21c6f7eac18f", + "image_id": 206927, + "image_name": "6673.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 274.82, + 63.62, + 187.73000000000002, + 134.09 + ], + "priority": -1, + "parents": [], + "children": [ + 164746, + 164745, + 164740, + 164742, + 164743, + 164741, + 164744 + ], + "area": 17484.0484, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 164740, + "strid": "65b04017-47b1-4efd-9405-b4e3a1ea6195", + "image_id": 206927, + "image_name": "6673.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 549.392, + 173.353, + 1901.3240000000003, + 297.189 + ], + "priority": 1, + "parents": [ + 164758 + ], + "children": [], + "area": 95238.75137600001, + "iscrowd": 0, + "segmentation": [], + "text": "THE INFLUENCE OF SEGMENTATION ON\nRAPID SCENE CATEGORIZATION" + }, + { + "id": 164741, + "strid": "710d9822-026e-4256-a9a5-73c6a700a317", + "image_id": 206927, + "image_name": "6673.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1083.059, + 539.96, + 1590.686, + 221.33400000000006 + ], + "priority": 2, + "parents": [ + 164758 + ], + "children": [], + "area": 584808.53764, + "iscrowd": 0, + "segmentation": [], + "text": "Caitlin R. Mullin, Lee H. de-Wit, Hans P. Op de Beeck,\nJohan Wagemans, Jonas Kubilius\nBrain & Cognition, University of Leuven (Belgium)" + }, + { + "id": 164742, + "strid": "01e03892-3575-4785-9ff3-74dda23fdd0f", + "image_id": 206927, + "image_name": "6673.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 69.319, + 867.295, + 589.446, + 110.64999999999998 + ], + "priority": 3, + "parents": [ + 164758 + ], + "children": [ + 164722, + 164732, + 164733 + ], + "area": 60120.022105, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 164722, + "strid": "82360f1c-2be0-413d-aa5e-a942b79b6eb0", + "image_id": 206927, + "image_name": "6673.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 148.733, + 1056.347, + 714.0840000000001, + 432.36699999999996 + ], + "priority": 4, + "parents": [ + 164742 + ], + "children": [], + "area": 157113.658351, + "iscrowd": 0, + "segmentation": [], + "text": "is fast (Thorpe et al., 1997; Oliva &\nTorralba, 2001)\n\nand can be accounted for by\nfeedforward processing (Serre et\nal., 2007; Krizhevsky et al., 2012)\nand therefore, requires no\nsegmentation" + }, + { + "id": 164732, + "strid": "ac05607b-e828-4576-9a6e-23c831255b5d", + "image_id": 206927, + "image_name": "6673.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 69.291, + 1578.38, + 795.588, + 406.3040000000001 + ], + "priority": 5, + "parents": [ + 164742 + ], + "children": [], + "area": 109367.52858, + "iscrowd": 0, + "segmentation": [], + "text": "HOWEVER,\n\nobject surfaces (Nakayama et al.,\n1995)\n\nor proto-objects (Rensink, 2000;\nPylyshyn, 2001) has been proposed\nas a basis for categorization" + }, + { + "id": 164733, + "strid": "7b9157df-c659-4f8f-8a71-de18d5a75058", + "image_id": 206927, + "image_name": "6673.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 69.502, + 2101.198, + 792.212, + 351.77700000000004 + ], + "priority": 6, + "parents": [ + 164742 + ], + "children": [], + "area": 146037.46339599998, + "iscrowd": 0, + "segmentation": [], + "text": "QUESTIONS\n\nHow fast is segmentation\ncomputed?\n\nCan it occur prior to categorization\n(at least to some extent)?" + }, + { + "id": 164743, + "strid": "66c4d783-a047-4934-bc68-8fc5ae65dc89", + "image_id": 206927, + "image_name": "6673.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1016.569, + 868.329, + 316.44000000000005, + 103.41200000000003 + ], + "priority": 7, + "parents": [ + 164758 + ], + "children": [ + 164730, + 164731, + 164723, + 164724, + 164725, + 164748 + ], + "area": 882716.3432009999, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 164723, + "strid": "14d877f1-e2dc-440b-a393-fb53e4e558c7", + "image_id": 206927, + "image_name": "6673.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1014.973, + 1059.36, + 1263.958, + 122.02700000000004 + ], + "priority": 8, + "parents": [ + 164743 + ], + "children": [], + "area": 1075221.7972799998, + "iscrowd": 0, + "segmentation": [], + "text": "IDEA Manipulate segmentation cues available to participants\nwho are completing a categorization task" + }, + { + "id": 164724, + "strid": "c60ad542-a67e-4764-8e2b-8e3743bb6a2a", + "image_id": 206927, + "image_name": "6673.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1067.701, + 1274.791, + 858.7080000000001, + 147.63699999999994 + ], + "priority": 9, + "parents": [ + 164743 + ], + "children": [], + "area": 1361095.625491, + "iscrowd": 0, + "segmentation": [], + "text": "segmentation influences categorization" + }, + { + "id": 164725, + "strid": "3d95c341-c310-4f21-8d23-1c952b37b721", + "image_id": 206927, + "image_name": "6673.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1329.833, + 1431.467, + 932.527, + 144.625 + ], + "priority": 10, + "parents": [ + 164743 + ], + "children": [], + "area": 1903612.0550110003, + "iscrowd": 0, + "segmentation": [], + "text": "segmentation is as fast as\ncategorization, i.e., feedforward" + }, + { + "id": 164748, + "strid": "30e8fe69-1b41-4403-90eb-7dea8b365f82", + "image_id": 206927, + "image_name": "6673.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1012.808, + 1669.497, + 1285.6639999999998, + 218.1289999999999 + ], + "priority": 11, + "parents": [ + 164743 + ], + "children": [], + "area": 1690879.917576, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 164731, + "strid": "a8d89450-ba70-4d8b-be8e-cb697ffd1d3e", + "image_id": 206927, + "image_name": "6673.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1018.369, + 2047.002, + 97.5200000000001, + 257.866 + ], + "priority": 12, + "parents": [ + 164743 + ], + "children": [], + "area": 2084603.379738, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 164730, + "strid": "8afacfcf-c163-4766-b0a6-5be9d7efb26f", + "image_id": 206927, + "image_name": "6673.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1183.902, + 1998.725, + 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"7ec33d92-fc3f-483e-b103-1b54d0d46076", + "image_id": 206927, + "image_name": "6673.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2473.701, + 1104.591, + 742.4920000000002, + 220.63200000000006 + ], + "priority": 15, + "parents": [ + 164744 + ], + "children": [], + "area": 2732427.8612909997, + "iscrowd": 0, + "segmentation": [], + "text": "Pre-segmentation cues and an\noccluding bar either support the\ncorrect grouping of the image halves\nor not" + }, + { + "id": 164727, + "strid": "a5fbb870-c694-4e48-bffc-98c69682bf1b", + "image_id": 206927, + "image_name": "6673.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2469.642, + 1488.597, + 738.56, + 58.82300000000009 + ], + "priority": 16, + "parents": [ + 164744 + ], + "children": [], + "area": 3676301.6722739995, + "iscrowd": 0, + "segmentation": [], + "text": "Do these cues influence participants?" + }, + { + "id": 164728, + "strid": "f186dd13-78f5-4180-aaaf-8a13b5df9aeb", + "image_id": 206927, + "image_name": "6673.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2447.856, + 1659.62, + 61.00199999999995, + 290.84899999999993 + ], + "priority": 17, + "parents": [ + 164744 + ], + "children": [], + "area": 4062510.77472, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 164749, + "strid": "0850e112-12f2-465f-8ac5-218d0a7393b4", + "image_id": 206927, + "image_name": "6673.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2560.309, + 1667.467, + 688.0879999999997, + 276.22900000000004 + ], + "priority": 18, + "parents": [ + 164744 + ], + "children": [], + "area": 4269230.767303, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 164729, + "strid": "6d1b66a5-e939-469b-925e-7a9e31dd30af", + "image_id": 206927, + "image_name": "6673.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2444.076, + 2053.954, + 59.335000000000036, + 348.5830000000001 + ], + "priority": 19, + "parents": [ + 164744 + ], + "children": 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"text": "Experiment | Red/blue pre-segmentation cues" + }, + { + "id": 164750, + "strid": "8f97e8ab-661e-4226-8645-0be778419fb9", + "image_id": 206927, + "image_name": "6673.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 371.657, + 2939.626, + 680.767, + 261.6100000000001 + ], + "priority": 22, + "parents": [ + 164745 + ], + "children": [], + "area": 1092532.5802820001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 164755, + "strid": "606922a2-b89c-43c1-b33a-c60ad34e92f9", + "image_id": 206927, + "image_name": "6673.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1197.322, + 2893.632, + 571.481, + 335.1390000000001 + ], + "priority": 23, + "parents": [ + 164745 + ], + "children": [], + "area": 3464609.2535039997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 164737, + "strid": "1de2a354-c893-4092-81cc-7609048b68b9", + "image_id": 206927, + "image_name": "6673.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 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segmentation cues" + }, + { + "id": 164739, + "strid": "83317710-c069-4915-a3d0-e7fd77297864", + "image_id": 206927, + "image_name": "6673.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1706.787, + 3771.513, + 1415.5249999999999, + 169.46399999999994 + ], + "priority": 34, + "parents": [ + 164745 + ], + "children": [], + "area": 6437169.358731, + "iscrowd": 0, + "segmentation": [], + "text": "These plots show the proportion of trials they could do so. It is\nharder to ignore segmentation when it is acting against categorization\n(i.e., incongruent trials)." + }, + { + "id": 164746, + "strid": "46e9acd0-76ed-418d-a4ee-529dc7247628", + "image_id": 206927, + "image_name": "6673.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 67.984, + 4069.582, + 596.188, + 107.25099999999975 + ], + "priority": 35, + "parents": [ + 164758 + ], + "children": [ + 164747 + ], + "area": 276666.46268799994, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 164747, + "strid": "23ddcd9e-9dba-4e47-9ae0-8d8c68305793", + "image_id": 206927, + "image_name": "6673.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 67.8, + 4249.911, + 3199.304, + 124.36300000000028 + ], + "priority": 36, + "parents": [ + 164746 + ], + "children": [], + "area": 288143.9658, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 116453, + "strid": "e675924b-baed-4510-acde-8dafcfdcdb7d", + "image_id": 205028, + "image_name": "13864.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 715.75, + 337.66, + 530.1199999999999, + 323.46 + ], + "priority": -1, + "parents": [], + "children": [ + 116423, + 116424, + 116438, + 116422, + 116427, + 116436, + 116421, + 116425, + 116437, + 116426 + ], + "area": 241680.14500000002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 116421, + "strid": "5d98625e-cc31-48da-b424-bfeda0d19800", + "image_id": 205028, + "image_name": "13864.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 1068.488, + 84.478, + 2128.8059999999996, + 241.31099999999998 + ], + "priority": 1, + "parents": [ + 116453 + ], + "children": [], + "area": 90263.729264, + "iscrowd": 0, + "segmentation": [], + "text": "Identifying Dynamic Connectivity States Using\nAffinity Propagation Clustering" + }, + { + "id": 116422, + "strid": "4fdbe83d-06c1-4cfe-bcca-cd4bcb562268", + "image_id": 205028, + "image_name": "13864.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1421.536, + 348.475, + 1480.726, + 160.118 + ], + "priority": 2, + "parents": [ + 116453 + ], + "children": [], + "area": 495369.75760000007, + "iscrowd": 0, + "segmentation": [], + "text": "Mustafa S Salman’2, Yuhui Du23 and Vince D Calhoun\" 2\n1University of New Mexico, 2The Mind Research Network, Albuquerque, NM, USA\n3Shanxi University, School of Computer & Information Technology, Taiyuan, China" + }, + { + "id": 116423, + "strid": "1d33fbd6-8021-423d-92d4-e76f2b93d6c5", + "image_id": 205028, + "image_name": "13864.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 422.33, + 677.759, + 439.23600000000005, + 74.332 + ], + "priority": 3, + "parents": [ + 116453 + ], + "children": [ + 116428 + ], + "area": 286237.95847, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 116428, + "strid": "35bf0bc6-b0df-447f-b1c7-f28f5d8d4cab", + "image_id": 205028, + "image_name": "13864.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 28.968, + 802.217, + 1213.258, + 956.58 + ], + "priority": 4, + "parents": [ + 116423 + ], + "children": [], + "area": 23238.622056, + "iscrowd": 0, + "segmentation": [], + "text": "Dynamic functional network connectivity (AFNC) analysis can\ncapture time-varying functional connectivity (FC) among\nbrain networks over tens of seconds (Calhoun et al., 2014).\nThe inherent connectivity states in the dynamic connectivity\npatterns can provide informative biomarkers for\ndistinguishing mental disorders.\n\nK-means clustering has been widely used to extract\nconnectivity states from time-varying FC. However its\nlimitations include susceptibility to local minima caused by\npoor initialization and slowness in convergence due to\nextensive noise in high-dimensional dynamic FC.\n\nWe propose to utilize an affinity propagation (AP) clustering\nbased method to estimate the connectivity states. By applying\nk-means and the new method separately, we analyzed\ndynamic FC of 82 healthy controls (HCs) and 82 schizophrenia\npatients (SZs), and explored group differences in the\nidentified connectivity states." + }, + { + "id": 116424, + "strid": "3c0d9a85-0b63-4e6b-a473-c8d53b014f94", + "image_id": 205028, + "image_name": "13864.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 279.575, + 1847.211, + 728.1879999999999, + 72.17200000000003 + ], + "priority": 5, + "parents": [ + 116453 + ], + "children": [ + 116442, + 116449, + 116441, + 116440, + 116448, + 116450, + 116439 + ], + "area": 516434.015325, + "iscrowd": 0, + "segmentation": [], + "text": "Materials & Methods" + }, + { + "id": 116441, + "strid": "7283f06d-da31-4472-86ca-ec0f2132e59d", + "image_id": 205028, + "image_name": "13864.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 30.164, + 1970.6, + 1215.744, + 194.96000000000004 + ], + "priority": 6, + "parents": [ + 116424 + ], + "children": [], + "area": 59441.1784, + "iscrowd": 0, + "segmentation": [], + "text": "Data\n\nResting-state [MRI data was collected from 82 healthy controls\n(HCs; age: 37.7 + 10.8, 19 females) and 82 schizophrenia\npatients (SZs; age: 38.0+14.0, 17 females)." + }, + { + "id": 116442, + "strid": "e0717def-1aa3-4cc1-8699-04d8edb1b753", + "image_id": 205028, + "image_name": "13864.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 32.441, + 2213.813, + 1199.294, + 392.17599999999993 + ], + "priority": 7, + "parents": [ + 116424 + ], + "children": [], + "area": 71818.30753300001, + "iscrowd": 0, + "segmentation": [], + "text": "Scanning parameters\n\nSubjects were scanned on a 3T Siemens Trio scanner at MRN.\nSubjects were asked to remain alert with eyes open and keep\ntheir head still. Scans were acquired using gradient echo\nplanar imaging (EPI) with parameters: echo time (TE) = 29ms,\nrepeat time (TR) = 2s, slice thickness = 3.5mm, slice gap =\n1.05mm, voxel size = 3.75mm x 3.75mm x 4.55mm. Scans\nconsisted of 150 whole brain images." + }, + { + "id": 116440, + "strid": "cb49c2d8-561b-434f-9a71-e85f9b717966", + "image_id": 205028, + "image_name": "13864.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 31.14, + 2655.144, + 1115.082, + 392.85199999999986 + ], + "priority": 8, + "parents": [ + 116424 + ], + "children": [], + "area": 82681.18415999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 116450, + "strid": "39ec56ed-12a6-471c-8a25-dff06fd5c79d", + "image_id": 205028, + "image_name": "13864.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 398.51, + 3071.597, + 490.446, + 71.91100000000006 + ], + "priority": 9, + "parents": [ + 116424 + ], + "children": [], + "area": 1224062.12047, + "iscrowd": 0, + "segmentation": [], + "text": "Spatial Group ICA" + }, + { + "id": 116449, + "strid": "ab04d91d-eb14-4f64-81cc-a47b17262bff", + "image_id": 205028, + "image_name": "13864.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 88.297, + 3170.207, + 1059.811, + 351.4090000000001 + ], + "priority": 10, + "parents": [ + 116424 + ], + "children": [], + "area": 279919.767479, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 116439, + "strid": "f28bdf2b-43ef-433d-bf17-10f82100d49c", + "image_id": 205028, + "image_name": "13864.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 30.16, + 3535.264, + 1197.176, + 247.34299999999985 + ], + "priority": 11, + "parents": [ + 116424 + ], + "children": [], + "area": 106623.56224, + "iscrowd": 0, + "segmentation": [], + "text": "A group-level spatial ICA was performed on the preprocessed\nfMRI data using Infomax algorithm to obtain group-level\nindependent components (ICs). Then subject-specific\ncomponents and corresponding time courses (TCs) were\ncalculated using GICA1 back-reconstruction." + }, + { + "id": 116448, + "strid": "8e32f6b7-07d8-4e3f-a5ed-9b776a703cf2", + "image_id": 205028, + "image_name": "13864.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 23.957, + 3807.169, + 1970.971, + 763.375 + ], + "priority": 12, + "parents": [ + 116424 + ], + "children": [], + "area": 91208.347733, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 116427, + "strid": "a95b76d3-3b26-4879-84c5-f7136f53a59c", + "image_id": 205028, + "image_name": "13864.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1550.564, + 678.385, + 1000.646, + 81.79700000000003 + ], + "priority": 13, + "parents": [ + 116453 + ], + "children": [ + 116431, + 116443, + 116429, + 116433, + 116430, + 116432, + 116451 + ], + "area": 1051879.35914, + "iscrowd": 0, + "segmentation": [], + "text": "Materials & Methods (contd.)" + }, + { + "id": 116443, + "strid": "29c95a91-4914-4ceb-b174-0ee4bef32424", + "image_id": 205028, + "image_name": "13864.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1643.217, + 814.037, + 817.0480000000002, + 133.476 + ], + "priority": 14, + "parents": [ + 116427 + ], + "children": [], + "area": 1337639.4370290001, + "iscrowd": 0, + "segmentation": [], + "text": "Dynamic Functional Network\nConnectivity Analysis" + }, + { + "id": 116451, + "strid": "defcd481-bd94-4173-9397-8fa37e4f8377", + "image_id": 205028, + "image_name": "13864.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1597.705, + 972.11, + 964.364, + 616.7390000000001 + ], + "priority": 15, + "parents": [ + 116427 + ], + "children": [], + "area": 1553145.00755, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 116429, + "strid": "8761cd96-2bb8-4a80-bb54-94a83e688624", + "image_id": 205028, + "image_name": "13864.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1437.452, + 1615.181, + 1211.1269999999997, + 404.88699999999994 + ], + "priority": 16, + "parents": [ + 116427 + ], + "children": [], + "area": 2321745.158812, + "iscrowd": 0, + "segmentation": [], + "text": "For analyzing dynamics, a sliding window method with size\nof 26 TR (52s) and step of 1 TR was used to separate each\nsubject component TC into 118 short TCs. Each window was\nconvolved with a Gaussian of o = 3 TR to obtain tapering\nalong the edges. FCs among networks were estimated based\non 36 networks’ short TCs in each window from a regularized\ninverse covariance matrix using graphical LASSO framework.\nThe connectivity values were then Fisher-Z transformed." + }, + { + "id": 116430, + "strid": "0f25663e-2692-4edb-bb87-b19f753c30cc", + "image_id": 205028, + "image_name": "13864.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1436.64, + 2063.762, + 1127.5940000000003, + 268.4749999999999 + ], + "priority": 17, + "parents": [ + 116427 + ], + "children": [], + "area": 2964883.0396800004, + "iscrowd": 0, + "segmentation": [], + "text": "Clustering & Statistical Comparison\n\nThe window direction-concatenated dFNC vectors of all\nsubjects were clustered separately using k-means and AP\nmethod to produce five clusters." + }, + { + "id": 116431, + "strid": "34f240d3-6ec5-46ad-bf02-a4f66644b28f", + "image_id": 205028, + "image_name": "13864.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1437.292, + 2385.64, + 1221.502, + 1064.5 + ], + "priority": 18, + "parents": [ + 116427 + ], + "children": [], + "area": 3428861.2868799996, + "iscrowd": 0, + "segmentation": [], + "text": "Affinity Propagation Clustering Method\n\nThis method performs clustering by using similarity measures\nbetween pairs of samples and propagating information until a\nhigh-quality set of exemplars and corresponding clusters\ngradually emerge (Frey and Dueck, 2007). It simultaneously\nconsiders information of all samples and avoids the problem\ncaused by poor initialization.\n\nThere are two kinds of messages exchanged between samples:\nresponsibility and availability. The update equation for\nresponsibilities is,\n\nr(i,k) —s(i,k) - mar. fae k)+s(i,k y}\n\nWhere s(i,k) indicates initial similarity. The update equation\nfor availabilities is,\n\na(i,k) — min{0,r(k,k) + , max {0,r(i,k )}\nis.t.i {LK}\n\nl\n\nAt any point during propagation, exemplars can be identified\nby combining responsibilities and availabilities" + }, + { + "id": 116432, + "strid": "3117b830-1cc9-41e4-9f1f-ff29299dc211", + "image_id": 205028, + "image_name": "13864.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1437.516, + 3503.973, + 1179.6979999999999, + 245.99699999999984 + ], + "priority": 19, + "parents": [ + 116427 + ], + "children": [], + "area": 5037017.251068, + "iscrowd": 0, + "segmentation": [], + "text": "Statistical comparison\n\nRegarding each method, the difference in each connectivity\nstrength between HCs and SZs was investigated using a two-\nsample T-test based on the corresponding subject-specific\nstates." + }, + { + "id": 116433, + "strid": "e262ed18-bd73-44c4-9a46-a948bb69b5ad", + "image_id": 205028, + "image_name": "13864.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2002.525, + 3809.426, + 608.3600000000001, + 538.5909999999999 + ], + "priority": 20, + "parents": [ + 116427 + ], + "children": [], + "area": 7628470.800650001, + "iscrowd": 0, + "segmentation": [], + "text": "The 36 functional networks\nobtained from Group ICA are\npresented in the figure on the\nleft. The networks are\ngrouped by their functional\ndomains: subcortical (SC),\nauditory (AUD), visual (VIS),\nsensorimotor (SM), cognitive\ncontrol (CC), default mode\nnetwork (DMN) and cerebellar\n(CB) networks." + }, + { + "id": 116426, + "strid": "26c04b15-7ad1-431e-9272-aa8730f21739", + "image_id": 205028, + "image_name": "13864.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3333.557, + 675.96, + 257.241, + 74.66100000000006 + ], + "priority": 21, + "parents": [ + 116453 + ], + "children": [ + 116447, + 116444, + 116445, + 116446, + 116434, + 116452 + ], + "area": 2253351.18972, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 116444, + "strid": "1ca407d2-e0a3-42ae-a8fc-ec6b10d135e8", + "image_id": 205028, + "image_name": "13864.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3057.438, + 834.413, + 813.098, + 133.00900000000001 + ], + "priority": 22, + "parents": [ + 116426 + ], + "children": [], + "area": 2551166.013894, + "iscrowd": 0, + "segmentation": [], + "text": "Dynamic Functional Network\nConnectivity States" + }, + { + "id": 116452, + "strid": "1b633a3a-a173-4600-b32a-96572c74bbe4", + "image_id": 205028, + "image_name": "13864.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2834.417, + 996.653, + 1243.0080000000003, + 552.116 + ], + "priority": 23, + "parents": [ + 116426 + ], + "children": [], + "area": 2824930.206301, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 116445, + "strid": "7c3c04cd-5986-452e-85b0-fc8c38e2ced3", + "image_id": 205028, + "image_name": "13864.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2845.857, + 1567.43, + 1200.6170000000002, + 248.36300000000006 + ], + "priority": 24, + "parents": [ + 116426 + ], + "children": [], + "area": 4460681.63751, + "iscrowd": 0, + "segmentation": [], + "text": "Two groups of five dFNC states each obtained from k-means\nand AP clustering methods respectively are displayed using a\nconnectogram plot. Compared to the other states, state 1\nestimated by both approach has the highest occupancy (and\nlower connectivity strengths)" + }, + { + "id": 116446, + "strid": "811ec28e-0cc5-4401-8cca-71f9c0e58012", + "image_id": 205028, + "image_name": "13864.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2865.867, + 1865.23, + 1190.0230000000001, + 138.89499999999998 + ], + "priority": 25, + "parents": [ + 116426 + ], + "children": [], + "area": 5345501.10441, + "iscrowd": 0, + "segmentation": [], + "text": "Statistical Comparison between controls &\npatients dFNC states" + }, + { + "id": 116447, + "strid": "7178eec0-0d7f-4f85-915b-1e336c0dd440", + "image_id": 205028, + "image_name": "13864.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2847.261, + 2033.152, + 1229.446, + 664.4490000000001 + ], + "priority": 26, + "parents": [ + 116426 + ], + "children": [], + "area": 5788914.396672, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 116434, + "strid": "bb28301b-b300-4746-8e15-d98785aa8c2d", + "image_id": 205028, + "image_name": "13864.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2843.766, + 2730.887, + 1206.8160000000003, + 698.241 + ], + "priority": 27, + "parents": [ + 116426 + ], + "children": [], + "area": 7766003.600442001, + "iscrowd": 0, + "segmentation": [], + "text": "The above connectogram plot shows the t-values obtained\nfrom the two-sample t-tests on the connectivity passing a\nsignificance level of p < 0.05 with false discovery rate (FDR)\ncorrection for multiple comparisons. Greater group\ndifferences were found using the AP clustering. In AP states 1\nand 2, SZ group had significant increased FCs than HC group\nin subcortical and sensorimotor networks connectivity. The\nfinding is supported by previous studies (Damaraju et al.,\n2014) but was absent using the k-means analysis here. Also,\nfor states 1-3, decreased FCs in SZ group between auditory,\nvisual and sensorimotor networks was highly conspicuous in\nAP results, consistent with previous studies. Furthermore,\nOnly the AP method was able to identify the SZ group's\ndysconnectivity in default mode network regions in state 1." + }, + { + "id": 116425, + "strid": "4ab1bb08-e9d1-451d-8bb5-2d48acfdd768", + "image_id": 205028, + "image_name": "13864.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3250.495, + 3532.006, + 418.19500000000016, + 74.18100000000004 + ], + "priority": 28, + "parents": [ + 116453 + ], + "children": [ + 116435 + ], + "area": 11480767.842969999, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 116435, + "strid": "170ea3ad-5231-4925-9929-ffc500af6408", + "image_id": 205028, + "image_name": "13864.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2942.137, + 3702.237, + 1010.0430000000001, + 738.268 + ], + "priority": 29, + "parents": [ + 116425 + ], + "children": [], + "area": 10892488.460469, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 116437, + "strid": "0458bccf-1062-453f-94cb-d8bab62b3125", + "image_id": 205028, + "image_name": "13864.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2255.792, + 5122.673, + 1213.1240000000003, + 184.38600000000042 + ], + "priority": 30, + "parents": [ + 116453 + ], + "children": [], + "area": 11555684.772015998, + "iscrowd": 0, + "segmentation": [], + "text": "Further information\nEmail: msalman@mrn.org, ydu@mrn.org, vcalhoun@mrn.org\nWebsite: http://mialab.mrn.org" + }, + { + "id": 116436, + "strid": "96b56fde-93cd-46f9-a4a4-736866b4504a", + "image_id": 205028, + "image_name": "13864.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2250.953, + 4653.847, + 1724.0750000000003, + 227.65099999999984 + ], + "priority": 31, + "parents": [ + 116453 + ], + "children": [], + "area": 10475590.866191, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgments\n\nThis work was in part funded by NIH grants P20GM103472 and RO1EB020407 (to\nCalhoun VD), and NSF grant 1539067 (to Calhoun VD) and by natural science foundation\nof Shanxi (2016021077, to Du Y)." + }, + { + "id": 116438, + "strid": "f28728c7-0fc2-4ec4-993a-6afaa914ab53", + "image_id": 205028, + "image_name": "13864.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 122.422, + 4650.054, + 1746.075, + 621.8639999999996 + ], + "priority": 32, + "parents": [ + 116453 + ], + "children": [], + "area": 569268.910788, + "iscrowd": 0, + "segmentation": [], + "text": "schizophrenia. NeuroImage Clin. 5,\n\nLiterature cited\n\n298-308.\nAllen et al., 2014. Tracking Whole-Brain Frey, B.J., Dueck, D., 2007. Clustering by\nConnectivity Dynamics in the Resting Passing Messages Between Data Points.\nState. Cereb. Cortex 24, 663-676. Science 315, 972-976.\n\nCalhoun et al., 2014. The Chronnectome:\nTime-Varying Connectivity Networks as\nthe Next Frontier in fMRI Data\nDiscovery. Neuron 84, 262-274\n\nDamaraju et al., 2014. Dynamic functional\nconnectivity analysis reveals transient\nstates of dysconnectivity in" + }, + { + "id": 67419, + "strid": "8c157da6-381b-40ab-8a32-cc551464e31e", + "image_id": 203143, + "image_name": "119775.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 717.3, + 94.95, + 338.43000000000006, + 178.8 + ], + "priority": -1, + "parents": [], + "children": [ + 67392, + 67390, + 67394, + 67409, + 67391, + 67393, + 67389 + ], + "area": 68107.635, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 67389, + "strid": "4c7d1bbb-b067-4bae-a9f5-b6ae6242927b", + "image_id": 203143, + "image_name": "119775.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 1486.512, + 70.452, + 2141.7430000000004, + 205.098 + ], + "priority": 1, + "parents": [ + 67419 + ], + "children": [], + "area": 104727.743424, + "iscrowd": 0, + "segmentation": [], + "text": "ARE YOU GOING TO EAT THAT?\n\nYour brain says “no” but your body says “maybe.”" + }, + { + "id": 67390, + "strid": "d523fbd5-938c-41d1-bdba-aca5b6abb4f0", + "image_id": 203143, + "image_name": "119775.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1133.377, + 322.202, + 2757.238, + 242.562 + ], + "priority": 2, + "parents": [ + 67419 + ], + "children": [], + "area": 365176.33615399996, + "iscrowd": 0, + "segmentation": [], + "text": "Jason W. Filindall, Kayla D. Stone,;‘and Claudia L. R. Gonzalez\nThe Brain in Action Laboratory, Department-of Kinesiology and Physicatl;Education\nUniversity_of,Lethbridge, Lethbridge AB(G@anada, T1K 3M4; jason.flindall@uleth.ca" + }, + { + "id": 67391, + "strid": "3d60c1ff-43bf-479f-87c9-3aa8435c9fc5", + "image_id": 203143, + "image_name": "119775.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 107.51, + 619.435, + 991.634, + 87.97699999999998 + ], + "priority": 3, + "parents": [ + 67419 + ], + "children": [ + 67395, + 67399, + 67398, + 67396 + ], + "area": 66595.45685, + "iscrowd": 0, + "segmentation": [], + "text": "Background and Rationale" + }, + { + "id": 67398, + "strid": "3377d05a-6c3d-4ca8-a6fd-7519ce97df58", + "image_id": 203143, + "image_name": "119775.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 110.086, + 753.363, + 2300.266, + 589.681 + ], + "priority": 4, + "parents": [ + 67391 + ], + "children": [], + "area": 82934.719218, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 67395, + "strid": "09297161-6716-4235-bde3-07395f527a2f", + "image_id": 203143, + "image_name": "119775.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 146.94, + 1362.75, + 1060.521, + 466.16599999999994 + ], + "priority": 5, + "parents": [ + 67391 + ], + "children": [ + 67401 + ], + "area": 200242.485, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 67401, + "strid": "d9ee21d2-9be8-4b84-ba63-fb1fc12dd892", + "image_id": 203143, + "image_name": "119775.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 140.161, + 1876.204, + 1056.388, + 180.66099999999983 + ], + "priority": 6, + "parents": [ + 67395 + ], + "children": [], + "area": 262970.628844, + "iscrowd": 0, + "segmentation": [], + "text": "Figure “1 — Right-handers’ maximum grip aperture for left- and right-handed grasp-\nto-place and = grasp-to-eat movements (N=11). Right-handed grasp-to-eat\nMovements were associated with significantly smaller MGAs_ than\\were right-\nhanded grasp-to-place movements, or left-handed movements, of “either type.\n\nSource: Flindall and Gonzalez (2013)." + }, + { + "id": 67396, + "strid": "144375ca-6e1e-411e-a2c4-082598605620", + "image_id": 203143, + "image_name": "119775.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1232.83, + 1310.336, + 1067.0590000000002, + 520.771 + ], + "priority": 7, + "parents": [ + 67391 + ], + "children": [ + 67402 + ], + "area": 1615421.53088, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 67402, + "strid": "58489fcc-0e86-4ef8-a43f-f0bdec954260", + "image_id": 203143, + "image_name": "119775.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1226.914, + 1876.461, + 1056.7139999999997, + 146.65200000000004 + ], + "priority": 8, + "parents": [ + 67396 + ], + "children": [], + "area": 2302256.271354, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2 — Left-handers’ maximum grip aperture for left- and right#handed grasp-to-\nplace and grasp-to-eat movements (N=17). Right-handed grasp-to-eat movements\nwere associated with significantly smaller MGAs than wete right-handed grasp-to-\nplace movements. Source: Flindall, Stone, and Gonzalez, 2014 (submitted)." + }, + { + "id": 67399, + "strid": "72f48d89-6a78-41cc-9af3-af8c8a730dbd", + "image_id": 203143, + "image_name": "119775.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 110.041, + 2078.336, + 2221.596, + 188.81500000000005 + ], + "priority": 9, + "parents": [ + 67391 + ], + "children": [], + "area": 228702.17177599997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 67394, + "strid": "b06ac2c2-60e5-486a-a4bd-bc436e1ce7de", + "image_id": 203143, + "image_name": "119775.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 84.15, + 2326.813, + 1039.631, + 83.9079999999999 + ], + "priority": 10, + "parents": [ + 67419 + ], + "children": [ + 67418, + 67413, + 67416, + 67412, + 67415, + 67411, + 67417 + ], + "area": 195801.31395, + "iscrowd": 0, + "segmentation": [], + "text": "Participants and Equipment" + }, + { + "id": 67411, + "strid": "ed053618-f198-41f2-b2ad-8474a5c45d0a", + "image_id": 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+ "image_id": 203143, + "image_name": "119775.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1876.158, + 2452.71, + 550.395, + 625.6970000000001 + ], + "priority": 16, + "parents": [ + 67394 + ], + "children": [ + 67405 + ], + "area": 4601671.488179999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 67405, + "strid": "5e1bedbd-42a5-4b7c-891a-21f956c734d6", + "image_id": 203143, + "image_name": "119775.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1890.623, + 3104.47, + 535.9009999999998, + 112.72800000000007 + ], + "priority": 17, + "parents": [ + 67416 + ], + "children": [], + "area": 5869382.38481, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 5 — Plate liquid-crystal glasses\n[Translucent Technologies, Toronto, ON,\nCanada]." + }, + { + "id": 67417, + "strid": "1d7c43ac-3aa4-4de3-a1cf-08cc1c352d6a", + "image_id": 203143, + "image_name": "119775.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 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Top: Cheerio\n(© General Mills)“Average diameter 11 mm.\nBottom: Froot,hoop{© Kellogg’s). Average\ndiameter 15.:mm." + }, + { + "id": 67392, + "strid": "6a8d1292-383f-47cc-bb21-6685ecaf6aaf", + "image_id": 203143, + "image_name": "119775.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2560.528, + 621.127, + 382.8589999999999, + 71.26999999999998 + ], + "priority": 22, + "parents": [ + 67419 + ], + "children": [ + 67400, + 67397 + ], + "area": 1590413.0750559997, + "iscrowd": 0, + "segmentation": [], + "text": "Procedure" + }, + { + "id": 67397, + "strid": "2f20afcd-c36e-4878-b36f-8411ed43e36d", + "image_id": 203143, + "image_name": "119775.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2602.708, + 753.244, + 2442.546, + 846.869 + ], + "priority": 23, + "parents": [ + 67392 + ], + "children": [ + 67403 + ], + "area": 1960474.184752, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 67403, + "strid": "4eaae143-16ba-422e-a420-3ebae6ce3b8c", + "image_id": 203143, + "image_name": "119775.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2609.129, + 1623.506, + 2429.71, + 87.80300000000011 + ], + "priority": 24, + "parents": [ + 67397 + ], + "children": [], + "area": 4235936.586274, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 7 — Experimental protocol. The bib.and trash receptacle were present during all conditions. ‘Dotted lines denote the path of the food item following\ninitial grasp in each task." + }, + { + "id": 67400, + "strid": "fbc6f434-f655-4ada-8dcb-d5f987945830", + "image_id": 203143, + "image_name": "119775.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2609.201, + 1719.618, + 2406.0510000000004, + 224.87799999999993 + ], + "priority": 25, + "parents": [ + 67392 + ], + "children": [], + "area": 4486829.005218, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 67393, + "strid": "6dd660c2-54a2-4d74-b85c-7a1a80a59c17", + "image_id": 203143, + "image_name": "119775.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2594.84, + 2003.122, + 273.0500000000002, + 69.3889999999999 + ], + "priority": 26, + "parents": [ + 67419 + ], + "children": [ + 67410 + ], + "area": 5197781.090480001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 67410, + "strid": "dd5d2771-bd24-4ef4-81d0-5ca6d56da8c5", + "image_id": 203143, + "image_name": "119775.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2540.15, + 2122.082, + 2053.6110000000003, + 1144.4940000000001 + ], + "priority": 27, + "parents": [ + 67393 + ], + "children": [ + 67408 + ], + "area": 5390406.5923, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 67408, + "strid": "f60f6192-4f46-4931-976b-3538693d0795", + "image_id": 203143, + "image_name": "119775.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 4599.791, + 2154.249, + 473.39800000000014, + 1056.63 + ], + "priority": 28, + "parents": [ + 67410 + ], + "children": [], + "area": 9909095.161959, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 8 — Hand x\nTask interaction on\nMGA. MGAs in both\nthe eat and spit\ntasks are\nsignificantly smaller\nthan those in the\nplace task (ps.03)\nwhen using the right\nhand, for both small\nand large food sizes.\nNo effect. of task\nwas observed\nduring left-handed\nmovements\n(p>.203)." + }, + { + "id": 67409, + "strid": "0fa98097-0316-498b-b3d9-1da333cf40ce", + "image_id": 203143, + "image_name": "119775.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2597.246, + 3321.814, + 394.0149999999999, + 65.22600000000011 + ], + "priority": 29, + "parents": [ + 67419 + ], + "children": [ + 67414 + ], + "area": 8627568.124244, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion" + }, + { + "id": 67414, + "strid": "bceabb08-5339-4d92-ba49-1930ab1f005f", + "image_id": 203143, + "image_name": "119775.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2607.327, + 3462.374, + 2432.0189999999993, + 386.74299999999994 + ], + "priority": 30, + "parents": [ + 67409 + ], + "children": [], + "area": 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—\nss\n\nGland extrusion" + }, + { + "id": 71359, + "strid": "a5cac49c-a4c3-4d09-832f-b377cf1e3d2e", + "image_id": 203283, + "image_name": "119991.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 60.761, + 2850.735, + 717.878, + 74.10300000000007 + ], + "priority": 11, + "parents": [ + 71358 + ], + "children": [ + 71354, + 71351 + ], + "area": 173213.509335, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 71354, + "strid": "57cd9f10-e2d6-4c07-bf1e-4de61f80a316", + "image_id": 203283, + "image_name": "119991.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 57.379, + 2093.482, + 2571.005, + 822.1239999999998 + ], + "priority": 12, + "parents": [ + 71359 + ], + "children": [], + "area": 120121.90367799999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 71351, + "strid": "e4cbe3ce-d919-4471-9f2d-5eb8283e738e", + "image_id": 203283, + "image_name": "119991.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 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"bbox": [ + 595.096, + 4025.342, + 562.7629999999999, + 212.44900000000007 + ], + "priority": 18, + "parents": [ + 71343 + ], + "children": [], + "area": 2395464.922832, + "iscrowd": 0, + "segmentation": [], + "text": "Diets select for\ndifferent courtship\nstrategies." + }, + { + "id": 71345, + "strid": "b3b02887-8dfd-457b-bd69-e3b919466dbd", + "image_id": 203283, + "image_name": "119991.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1336.406, + 4023.081, + 492.70000000000005, + 203.40800000000036 + ], + "priority": 19, + "parents": [ + 71343 + ], + "children": [], + "area": 5376469.586886, + "iscrowd": 0, + "segmentation": [], + "text": "No diet-induced\nreproductive\nisolation." + }, + { + "id": 71346, + "strid": "4d975ad7-117b-4729-a006-f79df0bfea55", + "image_id": 203283, + "image_name": "119991.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2006.524, + 4025.342, + 681.4180000000001, + 277.99100000000044 + ], + "priority": 20, + "parents": [ + 71343 + ], + "children": [], + "area": 8076945.331208, + "iscrowd": 0, + "segmentation": [], + "text": "Changes’ in courtship\nbehaviour suggest future\nroutes for reproductive\nisolation." + }, + { + "id": 71357, + "strid": "5afd6a18-d415-4103-8708-dbf7787a9852", + "image_id": 203283, + "image_name": "119991.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2850.41, + 4006.785, + 375.9859999999999, + 326.16300000000047 + ], + "priority": 21, + "parents": [ + 71343 + ], + "children": [], + "area": 11420980.031849999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 677, + "strid": "e33f10e3-c639-4ef2-890d-02e617d16b02", + "image_id": 200523, + "image_name": "10109.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 166.38, + 269.79, + 208.47000000000003, + 225.14999999999998 + ], + "priority": -1, + "parents": [], + "children": [ + 660, + 664, + 663, + 659, + 661, + 662 + ], + "area": 44887.660200000006, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 660, + "strid": "c8ccdf05-5f51-4b80-bb1c-03c10c0c9796", + "image_id": 200523, + "image_name": "10109.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 674.885, + 133.122, + 3987.147, + 110.827 + ], + "priority": 1, + "parents": [ + 677 + ], + "children": [], + "area": 89842.04097, + "iscrowd": 0, + "segmentation": [], + "text": "Increased ER Stress and Altered Mitochondrial Dynamics in Aged Airway Smooth Muscle" + }, + { + "id": 659, + "strid": "4812a9db-bba9-4f65-b666-bb8fac61219e", + "image_id": 200523, + "image_name": "10109.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 863.442, + 267.84, + 3612.255, + 170.45800000000003 + ], + "priority": 2, + "parents": [ + 677 + ], + "children": [], + "area": 231264.30527999997, + "iscrowd": 0, + "segmentation": [], + "text": "Pawan Sharma’, Shi Pan! and Deepak A Deshpande*\n1Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107" + }, + { + "id": 661, + "strid": "486fdd36-6036-4a7a-b51f-afc70d88b0c8", + "image_id": 200523, + "image_name": "10109.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1102.453, + 557.399, + 270.8890000000001, + 58.240999999999985 + ], + "priority": 3, + "parents": [ + 677 + ], + "children": [ + 652 + ], + "area": 614506.199747, + "iscrowd": 0, + "segmentation": [], + "text": "Abstract" + }, + { + "id": 652, + "strid": "e7701536-6d57-47a5-90fc-f397a64997f7", + "image_id": 200523, + "image_name": "10109.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 123.782, + 636.672, + 2237.758, + 553.2719999999999 + ], + "priority": 4, + "parents": [ + 661 + ], + "children": [], + "area": 78808.533504, + "iscrowd": 0, + "segmentation": [], + "text": "Rationale: It has been known that the respiratory functions decline with age resulting in reduced quality of life. However, age-dependent molecular\nchanges in respiratory cells such as airway smooth muscle (ASM) cells are not established. There are data suggesting that aging develops a greater\ninflammatory and lower anti-oxidant response compared to young, but whether these differences actually translate into loss of cellular functions is\nunknown. Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) along with mitochondrial homeostasis play fundamental roles in\nintracellular protein handling during inflammation. The UPR exists to improve protein folding for proper cellular homeostasis, and prevent cell damage\nfrom the accumulation of misfolded proteins. We investigated whether ER stress and mitochondrial homeostasis is changed with age in ASM cells.\nMethods & Results: ASM cells obtained from Young (12 months) and Aged (30 months) F344XBN rats were used to determine the ER stress markers at\nbaseline and after 24 to 120 hours of serum starvation using western blotting. Expression of hallmarks of UPR, BIP, and IRE1@ were measured in cell\nlysates obtained from Young and Aged ASM cells. MTT assay was used to measure the cell viability in ASM cells. Mitochondrial reactive oxygen species\n(ROS) generation was measured using a fluorescent assay. We found that ER stress or UPR hallmarks (BIP, IRE1) were induced in aged ASM cells\nwhen compared to Young. ROS generation was significantly higher in ASM cells from Old rats compared to Young. We also found greater cell death in\naged ASM cells at 72, 96 and 120 hours upon serum starvation when compared to Young. The induction of ER stress markers correlated with reduction\nof cell viability in aged ASM cells. Conclusions: Our results indicate that mitochondrial dysfunction along with increased ER stress/UPR in aged ASM\ncells contributes to reduced contractile responses of the airways with aging." + }, + { + "id": 663, + "strid": "2f76a0ec-4d88-4054-a380-62ec7ed72d21", + "image_id": 200523, + "image_name": "10109.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 525.459, + 1241.395, + 281.725, + 65.01299999999992 + ], + "priority": 5, + "parents": [ + 677 + ], + "children": [ + 671, + 658, + 670 + ], + "area": 652302.1753049999, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 671, + "strid": "bc525c15-8c16-40c7-a1b7-ba1e1ac293f6", + "image_id": 200523, + "image_name": "10109.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 125.98, + 1334.275, + 316.593, + 43.728000000000065 + ], + "priority": 6, + "parents": [ + 663 + ], + "children": [], + "area": 168091.96450000003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 658, + "strid": "356dcf6f-df59-4e1c-bff1-f7f98f7b57ec", + "image_id": 200523, + "image_name": "10109.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 270.817, + 1401.91, + 717.044, + 491.336 + ], + "priority": 7, + "parents": [ + 663 + ], + "children": [], + "area": 379661.06047, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 670, + "strid": "7a5abc24-d232-4289-acae-36e557a5bb97", + "image_id": 200523, + "image_name": "10109.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 128.743, + 1926.707, + 1098.772, + 1273.615 + ], + "priority": 8, + "parents": [ + 663 + ], + "children": [], + "area": 248050.039301, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 662, + "strid": "ce1f82fa-26f6-457c-900e-56f4fd76622f", + "image_id": 200523, + "image_name": "10109.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1687.573, + 1238.686, + 239.73700000000008, + 63.659000000000106 + ], + "priority": 9, + "parents": [ + 677 + ], + "children": [ + 657, + 656, + 654, + 653, + 675, + 673, + 674, + 655, + 672, + 676 + ], + "area": 2090373.049078, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 676, + "strid": "a3b2437f-899e-4da2-9fd6-2b1b9f3dc182", + "image_id": 200523, + "image_name": "10109.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1275.321, + 1384.733, + 1062.8090000000002, + 54.52800000000002 + ], + "priority": 10, + "parents": [ + 662 + ], + "children": [], + "area": 1765979.074293, + "iscrowd": 0, + "segmentation": [], + "text": "Aging ASM Cells Showed Reduced Cell Viability" + }, + { + "id": 657, + "strid": "0890e9d7-bb21-41fd-8b3c-eb4103e048b8", + "image_id": 200523, + "image_name": "10109.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1311.368, + 1516.438, + 958.5619999999999, + 605.2309999999998 + ], + "priority": 11, + "parents": [ + 662 + ], + "children": [ + 668 + ], + "area": 1988608.267184, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 668, + "strid": "2bfb456a-dead-40c8-a8f6-27b08a666159", + "image_id": 200523, + "image_name": "10109.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1285.796, + 2166.688, + 1067.9169999999997, + 203.98399999999992 + ], + "priority": 12, + "parents": [ + 657 + ], + "children": [], + "area": 2785918.763648, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. Young and aged rat ASM cells were subjected to serum deprivation from 24 h\nto 120 h and cell viability was measured using MTT assay. Relative cell viability (percent\nof control) was calculated using the equation: (mean OD of treated cells/mean OD of control\ncells) X 100. Primary airway smooth muscle cell cultures from 3-4 young and aged rats were\ncompared to each other at given time points. One Way ANOVA with multiple comparison\ntest (Bonferroni) was used, *p<0.05; **p<0.01." + }, + { + "id": 675, + "strid": "e1a4b9f9-a69e-4106-947f-4b0b53948d19", + "image_id": 200523, + "image_name": "10109.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1357.777, + 2419.443, + 897.2049999999999, + 57.58699999999999 + ], + "priority": 13, + "parents": [ + 662 + ], + "children": [], + "area": 3285064.058211, + "iscrowd": 0, + "segmentation": [], + "text": "Increased ER Stress Markers With Aging" + }, + { + "id": 656, + "strid": "21e62875-94a0-4c91-96f4-68fabf30837c", + "image_id": 200523, + "image_name": "10109.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1337.558, + 2513.958, + 968.848, + 371.17300000000023 + ], + "priority": 14, + "parents": [ + 662 + ], + "children": [ + 669 + ], + "area": 3362564.634564, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 669, + "strid": "37ce6abc-0559-460a-8f05-533224d3a714", + "image_id": 200523, + "image_name": "10109.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1287.51, + 2934.628, + 1069.631, + 270.8359999999998 + ], + "priority": 15, + "parents": [ + 656 + ], + "children": [], + "area": 3778362.89628, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2. Young and aged rat airway smooth muscle cells were used to measure ER\nstress markers and untranslated protein response (UPR). Young and aged rat ASM\ncells at sub-confluence were serum starved (F12 + 1% ITS) for 24, 48, 72, 96 and 120\nhours and protein lysates were obtained to perform western blotting for ER stress\nmarkers, IRE1q@ and BiP (GRP78). As shown in the figure (Top) there was a time-\ndependent increase in ER stress markers with aging. Data shown above are\nrepresentative of 3-4 different animals. Expression of GAPDH was used as loading\ncontrol (bottom image)." + }, + { + "id": 672, + "strid": "17689b0c-dfbf-4745-9c10-6e33c7501863", + "image_id": 200523, + "image_name": "10109.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2528.671, + 566.353, + 2039.4290000000005, + 48.813999999999965 + ], + "priority": 16, + "parents": [ + 662 + ], + "children": [], + "area": 1432120.4068629998, + "iscrowd": 0, + "segmentation": [], + "text": "Aging Increases Reactive Oxygen Species and Decreases Mitochondrial Membrane Potential" + }, + { + "id": 653, + "strid": "80180702-8cb5-48a7-89ba-561f7ad6a3c1", + "image_id": 200523, + "image_name": "10109.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2418.688, + 634.982, + 2218.9709999999995, + 683.8209999999999 + ], + "priority": 17, + "parents": [ + 662 + ], + "children": [ + 667 + ], + "area": 1535823.343616, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 667, + "strid": "410c1a6f-7171-450f-88ba-0a27919ec644", + "image_id": 200523, + "image_name": "10109.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2486.096, + 1331.982, + 2207.0130000000004, + 228.21000000000004 + ], + "priority": 18, + "parents": [ + 653 + ], + "children": [], + "area": 3311435.1222719997, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3. A). Effect of aging on mitochondrial reactive oxygen species (ROS) generation and mitochondrial functions in rat ASM cells. ROS was measured by confocal microscopy in\nyoung and aged cells at baseline and 48 hours after serum deprivation stained with Mitosox Red. Average cellular ROS levels were determined from 45-50 cells in triplicate dishes\nprepared from three different rat cell cultures. Histogram (Y-axis) shows normalized mitoSox fluroscenece intensity elevation in cellular ROS compared to time-matched, young rat\nASM cells. B). Effect of aging on mitochondrial trans-membrane potential (A,,). Young and aged rat ASM cells were loaded with JC-10 dye and the potential-dependent accumulation\nin the mitochondria (reduced AW,, indicated by a decrease in Red:Green fluorescence) measured directly using a plate reader. C). Oxygen consumption rate (OCR, an indicator of\nmitochondrial respiration) was measured at basal condition using Seahorse XF analyzer in young and aged ASM cells. Data represent the average values from triplicates of three\nindependent primary young and aged rat ASM cells. t-test, “p<0.05; **p<0.01." + }, + { + "id": 673, + "strid": "48d6a412-13e5-4dda-acda-0343a7f186f6", + "image_id": 200523, + "image_name": "10109.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2550.804, + 1588.133, + 888.1869999999999, + 105.47199999999998 + ], + "priority": 19, + "parents": [ + 662 + ], + "children": [], + "area": 4051016.008932, + "iscrowd": 0, + "segmentation": [], + "text": "Altered Mitochondrial Dynamics in Aged\nAirway Smooth Muscle" + }, + { + "id": 654, + "strid": "4234bd56-68ca-42b2-a6b6-7030f2569c31", + "image_id": 200523, + "image_name": "10109.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2444.22, + 1682.315, + 1068.2350000000001, + 1531.851 + ], + "priority": 20, + "parents": [ + 662 + ], + "children": [], + "area": 4111947.9693, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 674, + "strid": "26f72e0e-c44b-43da-9bff-85af474ea1d1", + "image_id": 200523, + "image_name": "10109.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3615.911, + 1589.493, + 1027.1549999999997, + 106.68100000000004 + ], + "priority": 21, + "parents": [ + 662 + ], + "children": [], + "area": 5747465.223123, + "iscrowd": 0, + "segmentation": [], + "text": "Role of Superoxide in Functional Properties of\nAirway Smooth Muscle" + }, + { + "id": 655, + "strid": "eb8953d0-8cd7-45d8-b24d-9b7801685ce1", + "image_id": 200523, + "image_name": "10109.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3571.42, + 1673.521, + 1073.228, + 692.2140000000002 + ], + "priority": 22, + "parents": [ + 662 + ], + "children": [ + 666 + ], + "area": 5976846.36982, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 666, + "strid": "588c06c6-d696-4d62-ade4-8470948bc0a5", + "image_id": 200523, + "image_name": "10109.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 3523.017, + 2378.566, + 1173.6779999999999, + 327.6970000000001 + ], + "priority": 23, + "parents": [ + 655 + ], + "children": [], + "area": 8379728.453621998, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 4. A). Young and aged rat ASM cells were labeled with mitotracker green, live cell\nimaging was performed using confocal microscopy. B). To further investigate the ultrastructural\ndetails, transmission electron microscopy was performed in ASM cells from young and aged rats\n(aged rats demonstrated increased swelling of mitochondria). C). Mitochondrial dynamics\nproteins Drp1 and Opa1 were measured using at basal and 24 h in young and aged rat ASM\ncells. D). To determine the role of ROS in determining ASM function, mouse tracheal rings were\nused with +Xanthine/Xanthine Oxidase (X/XO) at 30 min, 4 h, 24 h and isometric force to\nmethacholine (MCh) was measured using myograph. In a select set of experiments, airways\nwere treated with X/XO for 4 h, allowed to recover in fresh buffer for 30 min, and contractile\nresponses to MCh were measured." + }, + { + "id": 664, + "strid": "e6f90c3c-0ec5-4413-9d0b-2149116c4f73", + "image_id": 200523, + "image_name": "10109.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3546.905, + 2732.59, + 780.9580000000001, + 69.65200000000004 + ], + "priority": 24, + "parents": [ + 677 + ], + "children": [ + 665 + ], + "area": 9692237.13395, + "iscrowd": 0, + "segmentation": [], + "text": "Summary & Conclusions" + }, + { + "id": 665, + "strid": "23a9c5b2-4777-40fe-9195-62d465491854", + "image_id": 200523, + "image_name": "10109.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3529.872, + 2820.066, + 1170.935, + 392.1399999999999 + ], + "priority": 25, + "parents": [ + 664 + ], + "children": [], + "area": 9954472.011551999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 182310, + "strid": 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Investigations" + }, + { + "id": 182299, + "strid": "00f680b1-017c-44c4-a0e0-42a468f453c3", + "image_id": 207617, + "image_name": "8502.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 530.47, + 3994.732, + 817.0409999999999, + 1026.848 + ], + "priority": 11, + "parents": [ + 182291 + ], + "children": [ + 182297 + ], + "area": 2119085.48404, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 182297, + "strid": "868f810b-f9a5-4926-bf60-7678e7a61fec", + "image_id": 207617, + "image_name": "8502.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 680.219, + 3942.764, + 532.5619999999999, + 34.86499999999978 + ], + "priority": 12, + "parents": [ + 182299 + ], + "children": [], + "area": 2681942.9853160004, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. Dengue Testing Cascade" + }, + { + "id": 182292, + "strid": "6061c6fb-770e-4570-8a1b-fbdb74f3124b", + "image_id": 207617, + "image_name": "8502.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2291.881, + 743.135, + 235.65099999999984, + 52.702999999999975 + ], + "priority": 13, + "parents": [ + 182310 + ], + "children": [ + 182293, + 182302, + 182307, + 182303, + 182308, + 182304 + ], + "area": 1703176.986935, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 182302, + "strid": "82de02dd-ec29-4d3e-801f-f8bae549b70e", + "image_id": 207617, + "image_name": "8502.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1418.035, + 915.669, + 917.6230000000003, + 547.513 + ], + "priority": 14, + "parents": [ + 182292 + ], + "children": [ + 182300 + ], + "area": 1298450.690415, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 182300, + "strid": "faa778f6-683a-40ff-9ce8-ec2481414bed", + "image_id": 207617, + "image_name": "8502.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1380.149, + 855.552, + 363.31899999999996, + 36.563999999999965 + ], + "priority": 15, + "parents": [ + 182302 + ], + "children": [], + "area": 1180789.237248, + "iscrowd": 0, + "segmentation": [], + "text": "Table 2. Demographics" + }, + { + "id": 182303, + "strid": "fb870734-d30b-44da-a16b-0b4be90f9af0", + "image_id": 207617, + "image_name": "8502.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2428.343, + 916.25, + 966.913, + 545.7069999999999 + ], + "priority": 16, + "parents": [ + 182292 + ], + "children": [ + 182301 + ], + "area": 2224969.2737499997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 182301, + "strid": "86c16aca-c52d-4d25-a792-662d2bc4e632", + "image_id": 207617, + "image_name": "8502.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2387.064, + 855.86, + 465.5140000000001, + 36.83699999999999 + ], + "priority": 17, + "parents": [ + 182303 + ], + "children": [], + "area": 2042992.5950399998, + "iscrowd": 0, + "segmentation": [], + "text": "Table 3. 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Larrivee and 2A. Gini\n‘ Catholic Diocese of Charleston, SC USA. * San Camillo-Forlanini Hospital, Rome, ITALY" + }, + { + "id": 176280, + "strid": "865534f0-d1c9-43b9-86ff-cd9db08b5ccb", + "image_id": 207380, + "image_name": "7510.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 577.892, + 872.627, + 217.01199999999994, + 36.30799999999999 + ], + "priority": 3, + "parents": [ + 176304 + ], + "children": [ + 176287 + ], + "area": 504284.162284, + "iscrowd": 0, + "segmentation": [], + "text": "introduction" + }, + { + "id": 176287, + "strid": "361cd55f-f7a1-41e4-9968-abb8fd36ee27", + "image_id": 207380, + "image_name": "7510.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 96.982, + 956.897, + 1178.54, + 550.43 + ], + "priority": 4, + "parents": [ + 176280 + ], + "children": [], + "area": 92801.784854, + "iscrowd": 0, + "segmentation": [], + "text": "Since Rosensweig first demonstrated learning dependent changes in cortical tissue, the\nbrain’s functional plasticity has become a nearly universally accepted feature of its\noperation. Indeed, neurplasticity, understood to mean activity dependent synaptic\nchanges, appears to underwrite a spectrum of experience dependent behaviors including\nmotor skill acquisition, cliical psychotherapy, memorization, and learning. Moreover, it\nhas been variously invoked as the biologically based means by which to achieve individual\ntransformation and personal flourishing (Merzenich, 2013). Virtue acquisition, in\nparticular, is itself dependent on innate capacities that can be potentiated by\nreinforcement and converted to habits that by extension, may be neuroplastically\nconferred. Advocates of positive psychology, in fact, recommend a volitional\nstrengthening of positive character traits, virtues, as a form of preventive therapy\n(Peterson and Seligman, 2004). Neuromodulation of virtuous traits by direct intervention,\nhowever, has also been proposed for the purpose of enhancing moral and virtuous traits\n(Gini, 2011). We explore here the ethical implications of an externally mediated\nneurointervention vs an intrinsic and neuroplastic one as a means to modulate positive\ncharacter." + }, + { + "id": 176282, + "strid": "ab9c9870-f938-4183-a307-18141f5a43c2", + "image_id": 207380, + "image_name": "7510.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 140.826, + 1724.494, + 1108.044, + 37.4380000000001 + ], + "priority": 5, + "parents": [ + 176304 + ], + "children": [ + 176288, + 176290 + ], + "area": 242853.592044, + "iscrowd": 0, + "segmentation": [], + "text": "|. Positive Traits and Classical Virtues: Habitus Operativus Bonus" + }, + { + "id": 176288, + "strid": "c325b8f5-6a93-4a03-bea4-6dc17436468c", + "image_id": 207380, + "image_name": "7510.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 104.486, + 1834.206, + 1174.57, + 344.45000000000005 + ], + "priority": 6, + "parents": [ + 176282 + ], + "children": [], + "area": 191648.848116, + "iscrowd": 0, + "segmentation": [], + "text": "Taxonomic profiles of virtues (Peterson and Seligman, 2004) reveal the prevalence and\nendorsement of virtues by all cultures, though individual cultures vary in their respective\nemphasis. Traditionally, virtues have been defined in terms of their formation,\ndynamism, and orientation, features concisely expressed in the classical formulation of\nAquinas ‘habitus operativus bonus’. According to this definition virtues are understood to\nbe easily executed and stable dispositions (habits) that are formed through repetition\nand that become operative when external circumstances dictate. They are purposed for\nthe attainment of the ‘good’, an expressed normative value that is referenced to the\nrecipient of the action, but also beneficial for the agent in its character and\nneurotransformative aspects." + }, + { + "id": 176290, + "strid": "5b3b6c8c-cdeb-4b9c-a963-c03d0d9c627c", + "image_id": 207380, + "image_name": "7510.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 188.567, + 2393.279, + 1014.4839999999999, + 328.297 + ], + "priority": 7, + "parents": [ + 176282 + ], + "children": [ + 176289 + ], + "area": 451293.441193, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 176289, + "strid": "ba57c008-0cf7-4e39-972a-54feacecb487", + "image_id": 207380, + "image_name": "7510.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 336.265, + 2343.033, + 632.811, + 34.639000000000124 + ], + "priority": 8, + "parents": [ + 176290 + ], + "children": [], + "area": 787879.9917449999, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 176283, + "strid": "8adc7685-859e-486d-8567-b8c169f3297d", + "image_id": 207380, + "image_name": "7510.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 208.7, + 2903.139, + 886.521, + 38.82600000000002 + ], + "priority": 9, + "parents": [ + 176304 + ], + "children": [ + 176291, + 176294 + ], + "area": 605885.1093, + "iscrowd": 0, + "segmentation": [], + "text": "Multidimensionality as a Precondition for the Good" + }, + { + "id": 176291, + "strid": "946069d2-9f55-4269-a6cb-27f1e46716c4", + "image_id": 207380, + "image_name": "7510.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 94.985, + 2975.678, + 1173.837, + 485.24800000000005 + ], + "priority": 10, + "parents": [ + 176283 + ], + "children": [], + "area": 282644.77483, + "iscrowd": 0, + "segmentation": [], + "text": "The habitual inclination to action that is directed to human ‘good’ is preconditioned by\nthe intrinsic multidimensionality that is constitutive of human beings (Browning, 2006)\nThis multidimensionality, or ‘thickness’ (Ricoeur, 1992) reflects the intrinsic complexity\nof human beings that is the product of an evolutionary patrimony and cultural\ndevelopment. In the former, the neural structure is molded ‘bottom-up’ to establish pre-\naltruistic drives, e.g, kin altruism (Van de Waal,1996), and an emotional embedding\n(Damasio, 1999) to structure pre-moral goods (Browning, 2006). In the latter, ethical\negoism, that is the product of evolutionary programming, is further shaped ‘top-down’\nthrough a process of cultural development that increasingly reflects the distantiation\nbetween value and explicit reward (Ricoeur, 1992) that is characteristic of pre-moral\ngoods. Increasingly, in later development, value is imbued with the culturally substituted\nnotion of reflexive narrativity “Oneself as Another”. While the latter acknowledges the\npresence of an evolved psychobiological contribution this contribution is made\nsubordinate to the narrative value by means of explicit and habitually practiced virtue." + }, + { + "id": 176294, + "strid": "7576d70a-9c17-4ecd-8207-509874da3491", + "image_id": 207380, + "image_name": "7510.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1448.132, + 815.994, + 963.406, + 217.70899999999995 + ], + "priority": 11, + "parents": [ + 176283 + ], + "children": [ + 176293 + ], + "area": 1181667.023208, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 176293, + "strid": "0f5a2cab-23cb-441c-91b3-1a5eb11b5d1f", + "image_id": 207380, + "image_name": "7510.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1446.568, + 765.834, + 1042.914, + 40.90499999999997 + ], + "priority": 12, + "parents": [ + 176294 + ], + "children": [], + "area": 1107830.957712, + "iscrowd": 0, + "segmentation": [], + "text": "Table 2. Multidimensionality and Anthropological Identity" + }, + { + "id": 176285, + "strid": "8b8c6eda-b267-47b7-9ed7-6c4d861d8ceb", + "image_id": 207380, + "image_name": "7510.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1464.097, + 1335.519, + 1007.9550000000002, + 38.009000000000015 + ], + "priority": 13, + "parents": [ + 176304 + ], + "children": [ + 176297, + 176295 + ], + "area": 1955329.361343, + "iscrowd": 0, + "segmentation": [], + "text": "lll. Virtue Acquisition as a Complex Neural Transformation" + }, + { + "id": 176295, + "strid": "2c10eab9-1b2c-448b-9fb8-2fda57445477", + "image_id": 207380, + "image_name": "7510.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1377.933, + 1475.702, + 1168.8599999999997, + 308.40599999999995 + ], + "priority": 14, + "parents": [ + 176285 + ], + "children": [], + "area": 2033418.483966, + "iscrowd": 0, + "segmentation": [], + "text": "The constitutive multidimensionality of human beings makes evident the need to deploy\na spectrum of neural features during the formation of virtuous habits, which together\nsynergistically instantiate the value of the habitual act (Wojtyla, 1979). Included are\nmolecular and circuit structuring mechanisms such as Hebbian ‘wiring’, sensitization,\nhabituation, memory, and perceptual learning (Benfenati, 2007), for which repeated\ndeployment are required. To these ‘bottom-up’ processes must be added rationally\naffirmed, agent executed, ‘top-down’ processes (Ochsner etal, 2007). The plethora of\nmechanisms, in fact, underscores the complexity of the neural changes that are likely to\noccur during the construction of virtuous habits." + }, + { + "id": 176297, + "strid": "dc5406f7-1cf7-496c-a48b-a78d202dfb31", + "image_id": 207380, + "image_name": "7510.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1560.318, + 1990.493, + 781.559, + 642.4549999999999 + ], + "priority": 15, + "parents": [ + 176285 + ], + "children": [ + 176296 + ], + "area": 3105802.0567739997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 176296, + "strid": "19b2c19f-b74a-4247-b5db-23bf8eca63b9", + "image_id": 207380, + "image_name": "7510.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1495.917, + 1885.219, + 909.0099999999998, + 94.50999999999999 + ], + "priority": 16, + "parents": [ + 176297 + ], + "children": [], + "area": 2820131.150823, + "iscrowd": 0, + "segmentation": [], + "text": "Table 3. Neural Mechanisms Likely to be Deployed\nfor Forming Virtues" + }, + { + "id": 176284, + "strid": "b2e947b5-76f2-4d81-88c8-b5bd0c8efdd0", + "image_id": 207380, + "image_name": "7510.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1602.262, + 2775.573, + 729.8239999999998, + 37.04800000000023 + ], + "priority": 17, + "parents": [ + 176304 + ], + "children": [ + 176299, + 176292 + ], + "area": 4447195.146125999, + "iscrowd": 0, + "segmentation": [], + "text": "IV. Phenomenological Experience of Value" + }, + { + "id": 176292, + "strid": "c38c1735-1370-4655-bf41-4058578aa2e5", + "image_id": 207380, + "image_name": "7510.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1386.992, + 2886.633, + 1175.3080000000002, + 308.17999999999984 + ], + "priority": 18, + "parents": [ + 176284 + ], + "children": [], + "area": 4003736.8779359995, + "iscrowd": 0, + "segmentation": [], + "text": "Virtues constitute a genre of goal directed behavior that through habitual performance\nbecome directed specifically toward the acquisition of value. Culturally established and\nsubsumed within a mutually beneficial reflex narrative, they require rational selection\nand explicit endorsement (Hussar and Smith, 2010). Indeed, a rational determination of\nvalue is requisite to arrive at judgmental assessments that mediate between principle\nand premoral goods. Accordingly they are appropriated within such top down\nmechanisms as are intrinsic to the global neural platform, contextualized in its embodied\nand embedded setting. Thus understood they encapsulate cultural and personal values\nthat self-identify (Taylor, 1989)." + }, + { + "id": 176299, + "strid": "ce9928ca-fff2-4fd7-9c63-8d50f46300eb", + "image_id": 207380, + "image_name": "7510.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2753.659, + 934.067, + 973.366, + 336.0319999999999 + ], + "priority": 19, + "parents": [ + 176284 + ], + "children": [ + 176298 + ], + "area": 2572102.001153, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 176298, + "strid": "66dfe2a5-55a3-4330-92e7-445aa5316fda", + "image_id": 207380, + "image_name": "7510.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2751.698, + 842.82, + 772.9659999999999, + 34.38599999999997 + ], + "priority": 20, + "parents": [ + 176299 + ], + "children": [], + "area": 2319186.10836, + "iscrowd": 0, + "segmentation": [], + "text": "Table 4\n\nNeuroethics of Virtue Modulation" + }, + { + "id": 176286, + "strid": "f2dd9dfe-3151-478b-882d-a649361effaa", + "image_id": 207380, + "image_name": "7510.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2765.286, + 1435.692, + 969.3409999999999, + 37.8420000000001 + ], + "priority": 21, + "parents": [ + 176304 + ], + "children": [ + 176300 + ], + "area": 3970098.987912, + "iscrowd": 0, + "segmentation": [], + "text": "V. Ethical Considerations for Neuromodulation of Virtue" + }, + { + "id": 176300, + "strid": "3fb240e0-2175-4bd4-90b8-c7b111246eee", + "image_id": 207380, + "image_name": "7510.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2645.807, + 1529.011, + 1173.5029999999997, + 449.201 + ], + "priority": 22, + "parents": [ + 176286 + ], + "children": [], + "area": 4045468.0068769995, + "iscrowd": 0, + "segmentation": [], + "text": "A pertinent neuroethic of virtue modulation is, thus, cast against a broad swath of neural\nevents that together effect the formation of virtuous habits. In its train are also\nfreighted all accompanying neuroplastic changes which are correspondingly established\nand within which the selected values become instantiated. Included, therefore, are not\nsimply psychomotoric circuits that effect virtuous behavior, but also unitary global\nphenomena such as identity, agency, and rationality. The latter, in fact, are\nphilosophically invoked as constitutive of personhood, for which a normative ethical\ndomain is also reserved. Additionally, an ethic must seek preservation of the\norientational ‘telos’ that is intrinsic to each virtuous act (Gini, 2011). Finally, in\nconsideration of the pervasive neural apparatus so modified, one must also be aware of\nmultiple unknown and non-specific effects that may obtain. The complexity of the\nvirtuous act, and so also the prospect of any neural modulation, make normative\napproval remote." + }, + { + "id": 176281, + "strid": "6873c9eb-6992-4f3f-b6a8-bf734329e4e0", + "image_id": 207380, + "image_name": "7510.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3122.187, + 2097.302, + 210.779, + 38.69399999999996 + ], + "priority": 23, + "parents": [ + 176304 + ], + "children": [ + 176301 + ], + "area": 6548169.039474, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 176301, + "strid": "b80713c0-ef4a-425e-9234-93958ee99f08", + "image_id": 207380, + "image_name": "7510.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2654.628, + 2227.769, + 1179.429, + 366.2739999999999 + ], + "priority": 24, + "parents": [ + 176281 + ], + "children": [], + "area": 5913897.964931999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 176302, + "strid": "b8b86610-4f32-4302-b8e5-7430c07efd97", + "image_id": 207380, + "image_name": "7510.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2708.529, + 3040.794, + 178.3420000000001, + 28.748000000000047 + ], + "priority": 25, + "parents": [ + 176304 + ], + "children": [ + 176303 + ], + "area": 8236078.732026, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 176303, + "strid": "f67266e9-5154-49c0-be5c-12b9a5a20988", + "image_id": 207380, + "image_name": "7510.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2708.124, + 3083.314, + 1062.437, + 625.7049999999999 + ], + "priority": 26, + "parents": [ + 176302 + ], + "children": [], + "area": 8349996.642935999, + "iscrowd": 0, + "segmentation": [], + "text": "Benfenati, F (2007). Synaptic plasticity and the neurobiology of learning and memory. Acta\nBiomed. 78: 58 — 66.\nBrowning, D.S. (2006). Christian Ethics and the Moral Psychologies. Cambridge: Wm B.\nEerdman’s Publishing.\nDamasio, A. (1999). The Feeling of What Happens. New York: Harcourt Press.\nGini, A. (2011). Moral enhancement: Back to the future. In: Sanguineti, JJ, Acerbi, A, Lombo\nJA, eds. Moral Behavior and Free Will. Vatican City: IF Press.\nHussar, KM and Smith, PL (2010). Children who choose not to eat meat: A study of early moral\ndecision making. Soc. Develop. 19(3): 627 — 641.\nPeterson, C and Seligman, MEP (2004). Character Strengths and Virtues. New York, NY: Oxford\nU Press.\nMerzenich, M (2013). Soft-Wired: How the New Science of Brain Plasticity can Change Your\nLife. San Francisco: Parnassus Publishing.\nOchsner, KN, Ray, RR, Hughes, B (2007). Bottom up and top down processes in emotioin\ngeneration. Psychol Sci. 20(11):1322 — 1331.\nRicoeur, P. (1992). Oneself as Another. Chicago: U Chicago Press.\nTaylor, C. (1989). The Sources of the Self. Cambridge: Harvard U Press.\nVan de Waal, F. (1996). Good Natured. Cambridge: Harvard U Press.\nWojtyla, K (1979) The Acting Person Dordrecht, Holland: D Reidel Pubishing." + }, + { + "id": 139384, + "strid": "5187d48e-5d77-4ffb-a452-93765677ab5e", + "image_id": 205915, + "image_name": "16718.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 43.93, + 34.83, + 168.56, + 164.64999999999998 + ], + "priority": -1, + "parents": [], + "children": [ + 139373, + 139375, + 139385, + 139383, + 139374, + 139376 + ], + "area": 1530.0819, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 139385, + "strid": "efb63623-b841-455d-878e-675a1eba0632", + "image_id": 205915, + "image_name": "16718.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 64.71, + 307.6, + 743.52, + 132.40999999999997 + ], + "priority": 1, + "parents": [ + 139384 + ], + "children": [], + "area": 19904.796, + "iscrowd": 0, + "segmentation": [], + "text": "A suite of tools for working\nwith single-cell ATACseq data" + }, + { + "id": 139374, + "strid": "deb4d88b-1a12-4937-88db-7693da94833f", + "image_id": 205915, + "image_name": "16718.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 48.581, + 571.816, + 822.701, + 395.02099999999996 + ], + "priority": 2, + "parents": [ + 139384 + ], + "children": [], + "area": 27779.393096000003, + "iscrowd": 0, + "segmentation": [], + "text": "Ming Tang **, Brandon Logeman’, Catherine\n\nDulac??? and Tim Sackton?.\n\n1. Informatics, FAS, Harvard University\n\n2. Department of Molecular and Cellular Biology,\nHarvard University\n\nCenter for Brain Science, Harvard University\n4. Howard Hughes Medical Institute\n\nw" + }, + { + "id": 139375, + "strid": "33bbc363-bb51-4691-a7fc-ab089200dc49", + "image_id": 205915, + "image_name": "16718.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 63.499, + 1015.356, + 107.28, + 30.36200000000008 + ], + "priority": 3, + "parents": [ + 139384 + ], + "children": [ + 139377 + ], + "area": 64474.090644, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 139377, + "strid": "06ee8d93-a38b-4dc6-882b-e37d1d0ac19c", + "image_id": 205915, + "image_name": "16718.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 62.662, + 1071.019, + 753.99, + 563.846 + ], + "priority": 4, + "parents": [ + 139375 + ], + "children": [], + "area": 67112.192578, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 139376, + "strid": "0e9047c6-b681-47da-8f31-11f009063c0a", + "image_id": 205915, + "image_name": "16718.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 63.876, + 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package for quality control\n\nscATACseq data" + }, + { + "id": 139379, + "strid": "fb0384dc-e22b-41f9-85b4-dd9751a3c0fa", + "image_id": 205915, + "image_name": "16718.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 941.377, + 346.471, + 1227.263, + 369.63599999999997 + ], + "priority": 8, + "parents": [ + 139373 + ], + "children": [], + "area": 326159.83056699997, + "iscrowd": 0, + "segmentation": [], + "text": "Functions to calculate quality metrics in scATACutils package:\n\n \n\nCalculateFripScore() Fraction of reads in peaks\n\n \n\n \n\n \n\nCalculateBandingScore() | Measure nucleosome periodicity\n\n \n\n \n\n \n\nCalculateTssScore() Transcription start sites enrichment score" + }, + { + "id": 139380, + "strid": "1e1860ed-35e4-4654-9eeb-7e59d1ade86e", + "image_id": 205915, + "image_name": "16718.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1031.827, + 802.481, + 973.137, + 945.077 + ], + "priority": 9, + "parents": [ + 139373 + ], + 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Co-usage is understood as being cited in the same scientific publications.\nThe initial aim of the project is to identify how bioinformatics software relate to each other\nallowing to potentially infer analytical workflows commonly used from the literature." + }, + { + "id": 149166, + "strid": "2089af81-9f28-4f36-8ea8-145b19ab8615", + "image_id": 206294, + "image_name": "20594.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1401.553, + 1086.714, + 509.845, + 86.221 + ], + "priority": 4, + "parents": [ + 149183 + ], + "children": [ + 149173, + 149172, + 149168, + 149170, + 149169 + ], + "area": 1523087.266842, + "iscrowd": 0, + "segmentation": [], + "text": "Development" + }, + { + "id": 149168, + "strid": "78660ec1-4109-48be-8b6a-33f58bd171e6", + "image_id": 206294, + "image_name": "20594.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 132.356, + 1213.063, + 1442.805, + 141.19299999999998 + ], + "priority": 5, + "parents": [ + 149166 + ], + "children": [], + "area": 160556.166428, + "iscrowd": 0, + "segmentation": [], + "text": "~ Calculate the Co-occurrences: How many scientific >\npublications two articles have been referenced together." + }, + { + "id": 149172, + "strid": "030ae937-d94c-48f5-bc83-a079568371cc", + "image_id": 206294, + "image_name": "20594.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 217.259, + 1395.433, + 1316.782, + 482.18000000000006 + ], + "priority": 6, + "parents": [ + 149166 + ], + "children": [], + "area": 303170.378147, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 149170, + "strid": "425d6823-217f-4299-b5db-51bbb0c3fccb", + "image_id": 206294, + "image_name": "20594.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 105.209, + 1906.363, + 1481.078, + 365.6490000000001 + ], + "priority": 7, + "parents": [ + 149166 + ], + "children": [], + "area": 200566.54486700002, + "iscrowd": 0, + "segmentation": [], + "text": "The most direct way of knowing how the _ bioinformatics\ncommunity uses their software is by looking to the references in\ntheir scientific articles.\nThe theory is simple:\n\nTwo articles are closely related when there is high\n\\ co-occurrence between them. 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University; Research Urit of Liver Transplantation and Transplant immunology, Chinese Academy of Medical Sciences, Nanjing, Chins:" + }, + { + "id": 140309, + "strid": "f5a76181-293b-4298-a9b2-2593b0664999", + "image_id": 205957, + "image_name": "16812.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 160.284, + 147.343, + 56.29599999999999, + 14.990000000000009 + ], + "priority": 3, + "parents": [ + 140335 + ], + "children": [ + 140330, + 140329 + ], + "area": 23616.725411999996, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 140329, + "strid": "abf4b168-7092-43bf-9553-9bd47241b2a1", + "image_id": 205957, + "image_name": "16812.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 22.257, + 173.003, + 335.522, + 207.623 + ], + "priority": 4, + "parents": [ + 140309 + ], + "children": [], + "area": 3850.527771, + "iscrowd": 0, + "segmentation": [], + "text": "See eee Oren ee ae eee eee ee ee,\nexpression patterns during eatyT cell development serial for\nunceretanding tha iflerentation ard functions. All human T cals are\ndeveloned from thymus before adolescence, and all major subtypes ofT cells\nappear in the infant period. We cllected 5 thymic samples rom human\ninfants of t-month to t-year-oi oexplae characteristics ang functions of\nmultiple potans. We applied single-oll macs cytometry to measure the\nexpression of selected proteins, and inferred a T cel developmental Yee using\nceltorganiing map cutteing ané minimum spanning ree metho. All major\ncel subtypes during development were captured. We observed that protens\nassociate’ wih tha mature period of T cals are enriched in functions of cll\nactivation and polferaton,contibuting to cell population enlargement and\nfurther cflerantaion. We also eiscovered protein expression pater civing\ntothe development of unconventional Teel, incusng CD8+ tssue-tesident\nmemory T cols, Th 17 coll and Troge. Phosphorylatod anscrpbon factor in\nzeveral sgnaling pathways were found highly expressed in diferent stages,\nThe derived thyme T call Gevelopmental fee an proton expression patorns\nprovided a frat proteomic snapshot of eat) T ell develooment at single-cell\nDee neces" + }, + { + "id": 140330, + "strid": "98e145e4-1506-4dc9-8c4a-45f8c3f760b0", + "image_id": 205957, + "image_name": "16812.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 22.138, + 392.394, + 326.331, + 22.988999999999976 + ], + "priority": 5, + "parents": [ + 140309 + ], + "children": [], + "area": 8686.818372000002, + "iscrowd": 0, + "segmentation": [], + "text": "skate abies phil nbd S lament tein im\" nid imoanatal\nurti: Tool, developmen Son" + }, + { + "id": 140312, + "strid": "c3b617c4-d99f-418f-8cee-83dd75ff31b0", + "image_id": 205957, + "image_name": "16812.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 154.014, + 437.818, + 57.122000000000014, + 14.108000000000004 + ], + "priority": 6, + "parents": [ + 140335 + ], + "children": [ + 140322, + 140319 + ], + "area": 67430.101452, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 140319, + "strid": "93a59179-f0b5-469d-9d79-b822dcfe9622", + "image_id": 205957, + "image_name": "16812.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 26.129, + 463.66, + 326.501, + 173.71599999999995 + ], + "priority": 7, + "parents": [ + 140312 + ], + "children": [ + 140323 + ], + "area": 12114.972140000002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 140323, + "strid": "43597208-1720-4d77-863c-77cc861ae18d", + "image_id": 205957, + "image_name": "16812.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 22.049, + 649.489, + 327.436, + 67.03800000000001 + ], + "priority": 8, + "parents": [ + 140319 + ], + "children": [], + "area": 14320.582961, + "iscrowd": 0, + "segmentation": [], + "text": "eee ee ee ee ee ee\nnar a) enaa arm, ton ruanreg trannies ara\nUncone ngotar ging stra eal pe Down fe) Gases etoenee ng\n\n \n\n \n\n \n\nsn eum Posse ew ahs omg on ar\nsa carry ap SO stoi ts ra pine St) evens )\nee care re accent hee ene ene en Se" + }, + { + "id": 140322, + "strid": "2b9024ea-1c00-40bb-ad31-1b6f8dc653a0", + "image_id": 205957, + "image_name": "16812.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 22.603, + 734.664, + 331.498, + 81.63099999999997 + ], + "priority": 9, + "parents": [ + 140312 + ], + "children": [ + 140324 + ], + "area": 16605.610392000002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 140324, + "strid": "48f163a0-0f09-497c-87f7-3b2d80e52752", + "image_id": 205957, + "image_name": "16812.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 22.807, + 725.92, + 141.684, + 8.289999999999964 + ], + "priority": 10, + "parents": [ + 140322 + ], + "children": [], + "area": 16556.057439999997, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 140310, + "strid": "2be41d99-7044-47cf-bb17-107455a4555f", + "image_id": 205957, + "image_name": "16812.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 402.963, + 147.181, + 312.482, + 15.674000000000007 + ], + "priority": 11, + "parents": [ + 140335 + ], + "children": [ + 140316 + ], + "area": 59308.49730300001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 140316, + "strid": "7e0be197-0588-47df-bf8a-c738100168ab", + "image_id": 205957, + "image_name": "16812.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 387.051, + 175.315, + 325.55400000000003, + 172.925 + ], + "priority": 12, + "parents": [ + 140310 + ], + "children": [ + 140325 + ], + "area": 67855.84606499999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 140325, + "strid": "abf2a561-dd3e-4a06-bc49-b129e21ba3db", + "image_id": 205957, + "image_name": "16812.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 389.709, + 358.159, + 324.066, + 58.80200000000002 + ], + "priority": 13, + "parents": [ + 140316 + ], + "children": [], + "area": 139577.785731, + "iscrowd": 0, + "segmentation": [], + "text": "Citpietn and OMA channels to gat viable cas {c} Gras cata ware aalacod by gutng on event\n\n \n\nrae rc ens Epc aa anda evra epee) ra! re\nSbisrtehb onaned notre wre cen rare Bale thc cgeaon of 29.0\nCe acr ty inpenonhigdonae Py po eneloop ai" + }, + { + "id": 140313, + "strid": "2719cd9b-58bb-49e5-afdd-fecc485183cb", + "image_id": 205957, + "image_name": "16812.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 451.664, + 425.699, + 198.62300000000005, + 15.024999999999977 + ], + "priority": 14, + "parents": [ + 140335 + ], + "children": [ + 140317 + ], + "area": 192272.913136, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 140317, + "strid": "656eca25-dccc-472c-9445-629fa8e4d16d", + "image_id": 205957, + "image_name": "16812.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 389.849, + 449.713, + 324.637, + 63.02400000000006 + ], + "priority": 15, + "parents": [ + 140313 + ], + "children": [ + 140328 + ], + "area": 175320.163337, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 140328, + "strid": "ef57b338-2c5f-4998-a7cc-8abe2963527d", + "image_id": 205957, + "image_name": "16812.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 384.181, + 522.612, + 329.37600000000003, + 34.480999999999995 + ], + "priority": 16, + "parents": [ + 140317 + ], + "children": [], + "area": 200777.60077199998, + "iscrowd": 0, + "segmentation": [], + "text": "keine, Yen cn yen arches are ore nuteg COs COST oxla Code CDA Teer\natta. Thc gy Coes Yeas er ea Fact eon ad cae er Te\nepoine ela n eghe nantly aurannettbertegleamrstinen agen lng" + }, + { + "id": 140315, + "strid": "dee2fbbb-655f-49ae-85fd-7ffb911e52b5", + "image_id": 205957, + "image_name": "16812.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 388.257, + 563.907, + 325.1789999999999, + 14.702999999999975 + ], + "priority": 17, + "parents": [ + 140335 + ], + "children": [ + 140320 + ], + "area": 218940.84009900002, + "iscrowd": 0, + "segmentation": [], + "text": "Ihe developmental tree of T cells in human thymus" + }, + { + "id": 140320, + "strid": "8834cf4e-095a-466b-97a0-37f4f0ad739b", + "image_id": 205957, + "image_name": "16812.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 384.921, + 586.933, + 333.248, + 204.32799999999997 + ], + "priority": 18, + "parents": [ + 140315 + ], + "children": [ + 140332 + ], + "area": 225922.837293, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 140332, + "strid": "1e8d27b8-d97c-494d-a27e-cf4a6dcf8609", + "image_id": 205957, + "image_name": "16812.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 385.121, + 794.236, + 332.052, + 25.769000000000005 + ], + "priority": 19, + "parents": [ + 140320 + ], + "children": [], + "area": 305876.962556, + "iscrowd": 0, + "segmentation": [], + "text": "re ee eee ee ee ee wee ee eee\nruber) arr vacate fae ty espn 7, whch cols in ahr fo" + }, + { + "id": 140311, + "strid": "0ed7851a-0abb-448b-a341-3eef5eabc5cc", + "image_id": 205957, + "image_name": "16812.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 823.947, + 147.057, + 177.65800000000002, + 15.925999999999988 + ], + "priority": 20, + "parents": [ + 140335 + ], + "children": [ + 140318, + 140321 + ], + "area": 121167.17397899998, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 140318, + "strid": "d2660697-fcb4-48f8-be14-4049328ea482", + "image_id": 205957, + "image_name": "16812.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 747.67, + 171.652, + 328.3750000000001, + 196.233 + ], + "priority": 21, + "parents": [ + 140311 + ], + "children": [ + 140326 + ], + "area": 128339.05083999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 140326, + "strid": "7cda40f2-ba16-4965-afca-564bd19788f2", + "image_id": 205957, + "image_name": "16812.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 747.462, + 369.901, + 336.71000000000004, + 50.536 + ], + "priority": 22, + "parents": [ + 140318 + ], + "children": [], + "area": 276486.941262, + "iscrowd": 0, + "segmentation": [], + "text": "pv anrasice nee canes aero aca\nVelcro Uren a, COan sno Tech ron Cs COR bute Oyen\nUshi mle! en espn arctan aon HUCHADE 258s S08),\nSOE fe toon ini" + }, + { + "id": 140321, + "strid": "7b4819d8-047d-4408-ab28-0b0638ffca0c", + "image_id": 205957, + "image_name": "16812.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 747.105, + 427.962, + 333.1100000000001, + 134.04999999999995 + ], + "priority": 23, + "parents": [ + 140311 + ], + "children": [ + 140327 + ], + "area": 319732.55001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 140327, + "strid": "15c3b9e2-a0ff-4a83-8831-356c78367df3", + "image_id": 205957, + "image_name": "16812.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 748.195, + 564.612, + 332.1039999999999, + 50.250999999999976 + ], + "priority": 24, + "parents": [ + 140321 + ], + "children": [], + "area": 422439.87534, + "iscrowd": 0, + "segmentation": [], + "text": "career ean wer omaed wih one fo beara uP\nSeater Patt re\nCita 12 I regen ote wr ee te anes aa NR ea" + }, + { + "id": 140314, + "strid": "26b8193a-5b22-4c32-8787-699e7780b815", + "image_id": 205957, + "image_name": "16812.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 873.42, + 622.588, + 78.61500000000001, + 14.774000000000001 + ], + "priority": 25, + "parents": [ + 140335 + ], + "children": [ + 140331 + ], + "area": 543780.8109599999, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion:" + }, + { + "id": 140331, + "strid": "33be65a3-f189-41b8-89a7-fffac27f4df8", + "image_id": 205957, + "image_name": "16812.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 742.152, + 644.551, + 338.24, + 122.72400000000005 + ], + "priority": 26, + "parents": [ + 140314 + ], + "children": [], + "area": 478354.81375200005, + "iscrowd": 0, + "segmentation": [], + "text": "i a everest nar) cee tee eae\nthymus by using mass cylomety data. The results showed thatthe Tce\nmatuftion process eta fom pxo-T coll, which develop into CD4- D8. T\ncals, These cols proliferate to CDs COS> T cel, which then aubdiise ito\nbranches, such a8 CDS+ CDE-T cal branches and CO3+ CDs. T all,\nbranches. Several Feel subtypes were observed, including Tregs, Th17.COB+\nissue resident memory Tce and y+ cells The overall eoteinpaterne were\niustrated on he vee graphs. Specialy, the developmental wee with Treg\nterminus was assigned wth pseudotime, Treg revetant protein marke’ ends\nwere pltied with pseudolime, which showed CDs, CD25, Foxp3, CTLAS,\nICOS. TIGIT are key markers of Tregs." + }, + { + "id": 140333, + "strid": "e382f026-6dd8-4762-8604-88cbf3b3342d", + "image_id": 205957, + "image_name": "16812.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 853.855, + 778.501, + 117.71399999999994, + 15.788000000000011 + ], + "priority": 27, + "parents": [ + 140335 + ], + "children": [ + 140334 + ], + "area": 664726.971355, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgment" + }, + { + "id": 140334, + "strid": "d9b1a20c-183b-41e7-979c-450b58d682e8", + "image_id": 205957, + "image_name": "16812.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 771.031, + 805.408, + 279.48, + 9.700000000000045 + ], + "priority": 28, + "parents": [ + 140333 + ], + "children": [], + "area": 620994.535648, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 181549, + "strid": "f3f7366b-246c-43b2-bba7-f130d31f33f0", + "image_id": 207589, + "image_name": "8470.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 810.42, + 347.18, + 232.85000000000002, + 194.04000000000002 + ], + "priority": -1, + "parents": [], + "children": [ + 181508, + 181504, + 181502, + 181510, + 181507, + 181509, + 181506, + 181505, + 181503 + ], + "area": 281361.6156, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 181502, + "strid": "f2962b32-27b1-4101-a980-5a0387697e72", + "image_id": 207589, + "image_name": "8470.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 395.87, + 60.479, + 2788.575, + 240.62600000000003 + ], + "priority": 1, + "parents": [ + 181549 + ], + "children": [], + "area": 23941.82173, + "iscrowd": 0, + "segmentation": [], + "text": "FNCU AUNTIE Ree TUTTO MUA UCN En\nMalet LEAR U AM NSU RM ECOG H Ata RUN Das Qa od a Ra ANE" + }, + { + "id": 181503, + "strid": "244140ce-4e27-4899-be6d-8b72c6ff1e05", + "image_id": 207589, + "image_name": "8470.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1099.343, + 344.039, + 1398.168, + 143.69100000000003 + ], + "priority": 2, + "parents": [ + 181549 + ], + "children": [], + "area": 378216.866377, + "iscrowd": 0, + "segmentation": [], + "text": "Taru Singh’, Shukla Das’, V.G.Ramachandran 1,\nKhan Amir Maroof 2, Arvind Rai?" + }, + { + "id": 181504, + "strid": "8cbe8ee7-5a58-485c-9153-901b7c2c5272", + "image_id": 207589, + "image_name": "8470.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 443.84, + 781.111, + 388.47600000000006, + 41.60699999999997 + ], + "priority": 3, + "parents": [ + 181549 + ], + "children": [ + 181535 + ], + "area": 346688.30623999995, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 181535, + "strid": "ed78c953-1e03-4cd8-9dd8-a1c2c203ae6c", + "image_id": 207589, + "image_name": "8470.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 90.27, + 857.004, + 1089.632, + 455.188 + ], + "priority": 4, + "parents": [ + 181504 + ], + "children": [], + "area": 77361.75108, + "iscrowd": 0, + "segmentation": [], + "text": "Multidrug resistant Gram-negative bacteria are a major therapeutic challenge,\nboth in hospital and community settings [1]. Development of antimicrobial\nresistance in microorganisms has been attributed to indiscriminate use of\nantibiotics which poses serious public health concern worldwide [2]. Pathogenic\nE.coli strains could acquire resistance genes through horizontal gene transfer of\nmobile genetic elements like integrons. Integrons are versatile gene acquisition\nsystems commonly found in bacterial genomes. They are strongly associated\nwith the multidrug resistance in gram-negative bacilli in the hospital environment.\nAt present, E.coli populations are structured in seven major phylogenetic groups.\nProtein-Ligand docking is a molecular modelling technique used to predict the\norientation and confirmation of binding of ligands with proteins. An attempt was\nmade to create a 3D model and to find a suitable inhibitor using in silico study." + }, + { + "id": 181505, + "strid": "9d3ee0b5-c6cc-49fb-9873-95b5990b3c7f", + "image_id": 207589, + "image_name": "8470.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 493.803, + 1384.832, + 287.9920000000001, + 42.43599999999992 + ], + "priority": 5, + "parents": [ + 181549 + ], + "children": [ + 181536 + ], + "area": 683834.196096, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 181536, + "strid": "b64c151a-f2fb-49a0-9470-c1206d56fd77", + "image_id": 207589, + "image_name": "8470.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 90.264, + 1459.931, + 1086.953, + 221.98000000000002 + ], + "priority": 6, + "parents": [ + 181505 + ], + "children": [], + "area": 131779.21178399998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 181506, + "strid": "61e9e82a-3ed2-4c57-9106-f3395d639757", + "image_id": 207589, + "image_name": 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"children": [], + "area": 197143.978005, + "iscrowd": 0, + "segmentation": [], + "text": "The study protocol was approved by the institutional ethical committee." + }, + { + "id": 181539, + "strid": "db689a3d-9e61-4663-8b4f-a601cee82dbe", + "image_id": 207589, + "image_name": "8470.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 81.698, + 2224.444, + 1097.365, + 1066.507 + ], + "priority": 10, + "parents": [ + 181506 + ], + "children": [], + "area": 181732.625912, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 181507, + "strid": "c7bca53d-7bf5-4499-af7e-8cd27b50ac25", + "image_id": 207589, + "image_name": "8470.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 523.593, + 3352.988, + 229.57499999999993, + 40.67399999999998 + ], + "priority": 11, + "parents": [ + 181549 + ], + "children": [ + 181517, + 181515, + 181523, + 181520, + 181547, + 181525, + 181529, + 181518, + 181532, + 181541, + 181524, + 181527, + 181546, + 181526, + 181544, + 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agents of E.coli isolates\nfrom healthy volunteers and outpatients" + }, + { + "id": 181542, + "strid": "5ce2ac93-fbae-439f-ab19-208989641ea7", + "image_id": 207589, + "image_name": "8470.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 91.448, + 4209.296, + 968.1560000000001, + 96.44400000000041 + ], + "priority": 14, + "parents": [ + 181507 + ], + "children": [], + "area": 384931.700608, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 181544, + "strid": "2ebaa7c4-be84-49b1-b2f7-6315314f5361", + "image_id": 207589, + "image_name": "8470.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 87.754, + 4443.709, + 1092.178, + 258.02199999999993 + ], + "priority": 15, + "parents": [ + 181507 + ], + "children": [ + 181543 + ], + "area": 389953.239586, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 181543, + "strid": "c6fe3ce5-36d3-414e-911e-c8a48ba5b838", + "image_id": 207589, + "image_name": "8470.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 157.087, + 4358.278, + 954.1570000000002, + 64.70300000000043 + ], + "priority": 16, + "parents": [ + 181544 + ], + "children": [], + "area": 684628.816186, + "iscrowd": 0, + "segmentation": [], + "text": "Table 2-Primers used for amplifying integrons were based on previously\npublished literature :-" + }, + { + "id": 181529, + "strid": "ee455e0a-1187-4b04-94cb-44aa36f06664", + "image_id": 207589, + "image_name": "8470.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1260.582, + 783.899, + 1082.053, + 165.60199999999998 + ], + "priority": 17, + "parents": [ + 181507 + ], + "children": [], + "area": 988168.9692180001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 181521, + "strid": "fa6af3be-ca8a-4a34-96ff-f09de05f4e5a", + "image_id": 207589, + "image_name": "8470.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1353.767, + 970.699, + 850.182, + 341.19500000000005 + ], + "priority": 18, + "parents": [ + 181507 + ], + "children": [ + 181530 + ], + "area": 1314100.273133, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 181530, + "strid": "0c6486f3-8224-472a-bef0-2d55c2a5aff9", + "image_id": 207589, + "image_name": "8470.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1269.079, + 1341.19, + 1062.4369999999997, + 166.10799999999995 + ], + "priority": 19, + "parents": [ + 181521 + ], + "children": [], + "area": 1702076.06401, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1-Real-time PCR assay simultaneously detects integron genes. Data from\nindividual reaction mixtures, each containing DNA from respective strain, are\npresented in a single graph to show the separation between individual amplicon\nmelting curves. The Y-axis (fluorescence) represents the negative derivative of\nfluorescence over temperature." + }, + { + "id": 181532, + "strid": "4e3752ea-4544-4004-936e-c0ecc357b95c", + "image_id": 207589, + "image_name": "8470.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1256.564, + 1674.829, + 1088.318, + 216.34100000000012 + ], + "priority": 20, + "parents": [ + 181507 + ], + "children": [ + 181531 + ], + "area": 2104529.827556, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 181531, + "strid": "e0ee0e52-2422-4659-bfe3-8e54945630bf", + "image_id": 207589, + "image_name": "8470.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1346.932, + 1608.443, + 902.8329999999999, + 32.419000000000096 + ], + "priority": 21, + "parents": [ + 181532 + ], + "children": [], + "area": 2166463.346876, + "iscrowd": 0, + "segmentation": [], + "text": "Table 3- showing the production of integrons in cases and controls." + }, + { + "id": 181533, + "strid": "0c15e7a9-3176-4a60-a707-977ae1639cca", + "image_id": 207589, + "image_name": "8470.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1248.023, + 2105.704, + 1102.673, + 504.4290000000001 + ], + "priority": 22, + "parents": [ + 181507 + ], + "children": [ + 181534 + ], + "area": 2627967.023192, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 181534, + "strid": "3db7da86-5641-4da7-aad0-87e827a9677d", + "image_id": 207589, + "image_name": "8470.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1281.537, + 2023.75, + 1035.822, + 68.64899999999989 + ], + "priority": 23, + "parents": [ + 181533 + ], + "children": [], + "area": 2593510.50375, + "iscrowd": 0, + "segmentation": [], + "text": "Table 4: showing primer sequences and product size of genes in the extended\nquadruplex phylotyping method (Clermont et al. 2013)" + }, + { + "id": 181522, + "strid": "ac853c17-4e3d-4bf8-a4c2-1ba6bcea7cdb", + "image_id": 207589, + "image_name": "8470.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1452.007, + 2699.485, + 682.4810000000002, + 290.3800000000001 + ], + "priority": 24, + "parents": [ + 181507 + ], + "children": [ + 181545 + ], + "area": 3919671.1163950004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 181545, + "strid": "2415cc50-0d3d-4a91-95d8-a739adc2e361", + "image_id": 207589, + "image_name": "8470.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1286.892, + 3006.73, + 1046.3420000000003, + 68.94500000000016 + ], + "priority": 25, + "parents": [ + 181522 + ], + "children": [], + "area": 3869336.78316, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2- Amplified products of quadruplex PCR for phylogroups genes run on\n1.5% agarose gel." + }, + { + "id": 181546, + "strid": "b6c66b79-5784-41b9-9f8f-116176495be6", + "image_id": 207589, + "image_name": "8470.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1252.415, + 3122.685, + 1090.208, + 86.51600000000008 + ], + "priority": 26, + "parents": [ + 181507 + ], + "children": [], + "area": 3910897.534275, + "iscrowd": 0, + "segmentation": [], + "text": "79 isolates were found to be multidrug resistant. There was predominance of phylogenetic\ngroup A (38) followed by phylogenetic groups B1 (14), D (7), F (6), B2 (11), C (2) and E (1).\nOne isolate remain unclassified." + }, + { + "id": 181547, + "strid": "f0a3af82-941e-42aa-8e1c-5c9e23d04f37", + "image_id": 207589, + "image_name": "8470.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1263.874, + 3292.048, + 1089.497, + 95.9380000000001 + ], + "priority": 27, + "parents": [ + 181507 + ], + "children": [], + "area": 4160733.873952, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 181523, + "strid": "06008bc1-f5de-4e63-b4ae-c38da550adb1", + "image_id": 207589, + "image_name": "8470.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1445.893, + 3453.391, + 732.931, + 415.5909999999999 + ], + "priority": 28, + "parents": [ + 181507 + ], + "children": [], + "area": 4993233.873163, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 181527, + "strid": "15d7810b-31d4-4a80-8f06-b2b0ad267871", + 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"area": 5676996.684791, + "iscrowd": 0, + "segmentation": [], + "text": "Cavity points generated by active site finder in protein. site 1 is highly conserved" + }, + { + "id": 181525, + "strid": "edaafbc9-0e68-40a3-a0ce-401caf406483", + "image_id": 207589, + "image_name": "8470.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1497.147, + 4539.275, + 93.77500000000009, + 148.36200000000008 + ], + "priority": 32, + "parents": [ + 181507 + ], + "children": [], + "area": 6795961.948425, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 181548, + "strid": "7aff3844-df71-46f7-babb-d235e2828135", + "image_id": 207589, + "image_name": "8470.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1890.085, + 4541.448, + 108.45299999999997, + 147.89000000000033 + ], + "priority": 33, + "parents": [ + 181507 + ], + "children": [], + "area": 8583722.743080001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 181519, + "strid": 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Dendrogram analysis of E. coli strains harboring class 1 and 2\nintegrons. Evolutionary analyses were conducted in MEGA6 (4)." + }, + { + "id": 181510, + "strid": "119569f4-c6ab-4803-ba49-ea99512d9a5b", + "image_id": 207589, + "image_name": "8470.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2797.202, + 2917.803, + 335.4169999999999, + 42.53800000000001 + ], + "priority": 42, + "parents": [ + 181549 + ], + "children": [ + 181528 + ], + "area": 8161684.387206, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 181528, + "strid": "8c5eda03-7c01-4749-9f59-0ef8335e0712", + "image_id": 207589, + "image_name": "8470.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2426.048, + 3005.475, + 1075.917, + 758.2460000000001 + ], + "priority": 43, + "parents": [ + 181510 + ], + "children": [], + "area": 7291426.612799999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 181508, + "strid": "19ebd4c6-5101-4480-b81a-73aaccd84bdd", + "image_id": 207589, + "image_name": "8470.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2688.548, + 4277.626, + 539.779, + 41.521999999999935 + ], + "priority": 44, + "parents": [ + 181549 + ], + "children": [ + 181511 + ], + "area": 11500602.827048, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 181511, + "strid": "a7bc2e76-c7fe-446d-a651-bf764423f487", + "image_id": 207589, + "image_name": "8470.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2424.896, + 4376.487, + 1079.438, + 188.9359999999997 + ], + "priority": 45, + "parents": [ + 181508 + ], + "children": [], + "area": 10612525.820352001, + "iscrowd": 0, + "segmentation": [], + "text": "Special thanks to all children (and their parents) who participated in the\nresearch. We also acknowledged the assistance rendered by laboratory staff of\ncollege who assisted us in the collection of samples. We are also thankful to\nCSIR for financial support and National Institute of Cholera and Enteric Diseases\n(NICED Kolkata, India) for providing the reference strains." + }, + { + "id": 181509, + "strid": "54e75dce-7c81-4b2b-9017-5661797a2d2d", + "image_id": 207589, + "image_name": "8470.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2791.392, + 3831.056, + 335.6930000000002, + 42.60100000000011 + ], + "priority": 46, + "parents": [ + 181549 + ], + "children": [ + 181512 + ], + "area": 10693979.069952, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 181512, + "strid": "6100c4d3-6f4b-4b8f-91fc-987fb200cf1e", + "image_id": 207589, + "image_name": "8470.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2425.025, + 3912.994, + 1076.8610000000003, + 268.4739999999997 + ], + "priority": 47, + "parents": [ + 181509 + ], + "children": [], + "area": 9489108.274850002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 54002, + "strid": "62d49f32-5e92-4112-8d4b-f05c53f41c75", + "image_id": 202625, + "image_name": "118976.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 42.27, + 368.68, + 266.12, + 288.29 + ], + "priority": -1, + "parents": [], + "children": [ + 53983, + 53980, + 53994, + 53991, + 53982, + 53981, + 53993, + 54000 + ], + "area": 15584.103600000002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 53980, + "strid": "3f1bf4d4-38d1-4886-8129-f35eb7c5987d", + "image_id": 202625, + "image_name": "118976.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 179.115, + 276.545, + 3099.2610000000004, + 246.95300000000003 + ], + "priority": 1, + "parents": [ + 54002 + ], + "children": [], + "area": 49533.35767500001, + "iscrowd": 0, + "segmentation": [], + "text": "Functioning, fatigue and psychosocial features of ALS/MND:\nassociations, change over time and impact on patient quality of life" + }, + { + "id": 53981, + "strid": "c57c5bd8-12a2-4bc9-a4d6-ab261145dc5c", + "image_id": 202625, + "image_name": "118976.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 315.225, + 542.896, + 2872.601, + 132.89 + ], + "priority": 2, + "parents": [ + 54002 + ], + "children": [], + "area": 171134.3916, + "iscrowd": 0, + "segmentation": [], + "text": "Gibbons, CJ? , Young, CA?. on behalf of the TONIC Group UK 1. The Walton Centre, Liverpool 2. NIHR CLAHRC-GM, University of Manchester\nContact’; chris.gibbons@machester/carolyn.young@thewaltoncentre.nhs.uk" + }, + { + "id": 53982, + "strid": "b4a5385d-5eed-47c4-9c97-e0e29828c04b", + "image_id": 202625, + "image_name": "118976.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 84.288, + 750.948, + 790.963, + 93.09799999999996 + ], + "priority": 3, + "parents": [ + 54002 + ], + "children": [ + 53984 + ], + "area": 63295.90502399999, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 53984, + "strid": "6b5505b9-0e14-41fb-867d-d8880a0a36d5", + "image_id": 202625, + "image_name": "118976.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 28.6, + 892.225, + 1940.788, + 457.1170000000001 + ], + "priority": 4, + "parents": [ + 53982 + ], + "children": [], + "area": 25517.635000000002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 53983, + "strid": "c1a3098c-d2c7-4540-b263-6729a92695f4", + "image_id": 202625, + "image_name": 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This potential non-linear relationship between\nQoL and functional status warrants further investigation ina\nlongitudinal cohort study." + }, + { + "id": 53988, + "strid": "94e33d4a-c301-427c-b5f8-8763fbbe355f", + "image_id": 202625, + "image_name": "118976.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2065.937, + 2098.134, + 549.9560000000001, + 1138.3360000000002 + ], + "priority": 16, + "parents": [ + 54000 + ], + "children": [], + "area": 4334612.661557999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 53989, + "strid": "75967070-4d5a-4209-bd10-f890a662d337", + "image_id": 202625, + "image_name": "118976.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2716.969, + 2141.957, + 674.625, + 1036.8759999999997 + ], + "priority": 17, + "parents": [ + 54000 + ], + "children": [ + 53990 + ], + "area": 5819630.768333, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 53990, + "strid": "2f5b2f08-caa6-4a13-9a78-db2407765c8f", + "image_id": 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Those improvements are becoming even more critical with the\nadvent of ambitious large scale biodiversity sequencing project such as the\nDarwin tree of life project." + }, + { + "id": 143566, + "strid": "51580250-060a-4879-97ef-5bc394e001f7", + "image_id": 206080, + "image_name": "17355.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1534.745, + 455.781, + 1715.4880000000003, + 856.9940000000001 + ], + "priority": 5, + "parents": [ + 143553 + ], + "children": [], + "area": 699507.610845, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143554, + "strid": "dffa72d8-992d-4cb9-a2e5-a6ffe538371f", + "image_id": 206080, + "image_name": "17355.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 44.981, + 1023.094, + 1307.709, + 64.35799999999995 + ], + "priority": 6, + "parents": [ + 143576 + ], + "children": [ + 143564, + 143568, + 143575, + 143567, + 143560, + 143559, + 143561 + ], + "area": 46019.791214000004, + "iscrowd": 0, + "segmentation": [], + "text": "From quadratic to linear complexity methods" + }, + { + "id": 143564, + "strid": "787dd6e9-70af-4e46-a142-a63edb88efc4", + "image_id": 206080, + "image_name": "17355.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 83.323, + 1127.759, + 1232.166, + 227.6959999999999 + ], + "priority": 7, + "parents": [ + 143554 + ], + "children": [], + "area": 93968.263157, + "iscrowd": 0, + "segmentation": [], + "text": "By switching to a Hidden Markov Model (HMM) classification to group\nsequences into families, we moved from a computation that grows\nquadratically with the number of species to a computation that grows\nlinearly. This has also improved the specificity of our homology\nannotation." + }, + { + "id": 143567, + "strid": "6b14343e-8493-438b-8d16-5e1398826774", + "image_id": 206080, + "image_name": "17355.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 61.758, + 1395.333, + 1321.205, + 636.135 + ], + "priority": 8, + "parents": [ + 143554 + ], + "children": [], + "area": 86172.97541400002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143561, + "strid": "155d82e8-51f9-4a7a-9b05-894f9bd5df92", + "image_id": 206080, + "image_name": "17355.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 178.729, + 2074.773, + 1002.212, + 42.309999999999945 + ], + "priority": 9, + "parents": [ + 143554 + ], + "children": [], + "area": 370822.10351700004, + "iscrowd": 0, + "segmentation": [], + "text": "Overview of the current gene-tree reconstruction workflow." + }, + { + "id": 143568, + "strid": "a767e805-4a14-4d9f-bc13-3303b8820c84", + "image_id": 206080, + "image_name": "17355.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1505.45, + 1470.882, + 703.5730000000001, + 483.81500000000005 + ], + "priority": 10, + "parents": [ + 143554 + ], + "children": [], + "area": 2214339.3069, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143560, + "strid": "0ec9714a-4233-4e44-be7e-674d534ee52b", + "image_id": 206080, + "image_name": "17355.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1486.495, + 1965.895, + 920.2930000000001, + 180.86099999999988 + ], + "priority": 11, + "parents": [ + 143554 + ], + "children": [], + "area": 2922293.088025, + "iscrowd": 0, + "segmentation": [], + "text": "Gene order conservation (GOC) score measures the\nquality of orthology prediction based on the order\nconservation of neighbour genes. The HMM based\napproach has an overall better GOC score." + }, + { + "id": 143575, + "strid": "0f4eeb55-7046-4544-8e6b-12d9042c2ffb", + "image_id": 206080, + "image_name": "17355.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2412.078, + 1461.319, + 842.3160000000003, + 480.17599999999993 + ], + "priority": 12, + "parents": [ + 143554 + ], + "children": [], + "area": 3524815.410882, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143559, + "strid": "9c16b395-66e3-46e7-a144-0c24f29f983b", + "image_id": 206080, + "image_name": "17355.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2493.631, + 1957.218, + 761.5360000000001, + 183.31499999999983 + ], + "priority": 13, + "parents": [ + 143554 + ], + "children": [], + "area": 4880579.478558, + "iscrowd": 0, + "segmentation": [], + "text": "We used the Jaccard index to assess the\nsimilarity between our two approaches.\nOverall the HMM approach shows a good\noverlap with the Blast based clustering." + }, + { + "id": 143563, + "strid": "fb81feef-db52-43f3-8f7c-70d553632174", + "image_id": 206080, + "image_name": "17355.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 87.456, + 2270.128, + 1757.292, + 161.64499999999998 + ], + "priority": 14, + "parents": [ + 143576 + ], + "children": [], + "area": 198536.31436800002, + "iscrowd": 0, + "segmentation": [], + "text": "Infrastructure. the amount of compute requires a fast and fail-proof system. The generation\nof the comparative analyses typically peaks at 6,000 concurrent jobs / 30 TB RAM, all managed by\nthe eHive workflow manager, continuously improved by Ensembl since 2004." + }, + { + "id": 143569, + "strid": "196b456f-d8ba-497d-9303-83d09b7bf876", + "image_id": 206080, + "image_name": "17355.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 100.067, + 2480.299, + 1241.732, + 942.0340000000001 + ], + "priority": 15, + "parents": [ + 143576 + ], + "children": [], + "area": 248196.08003299998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143562, + "strid": "f274e31b-759a-4c7d-85f8-66c01e8f35de", + "image_id": 206080, + "image_name": "17355.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1278.384, + 2470.129, + 567.299, + 274.39300000000003 + ], + "priority": 16, + "parents": [ + 143576 + ], + "children": [], + "area": 3157773.3915359997, + "iscrowd": 0, + "segmentation": [], + "text": "eHive has a powerful graphical\ninterface to display the workflow\nstructure, monitor the execution,\nmodify parameters on-the-fly,\nand manage failures, as well as\ndetailed resource usage reports." + }, + { + "id": 143570, + "strid": "61b56a3c-c3c1-4841-a1c6-2664b5d577c1", + "image_id": 206080, + "image_name": "17355.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1375.863, + 2804.512, + 430.4269999999999, + 604.569 + ], + "priority": 17, + "parents": [ + 143576 + ], + "children": [], + "area": 3858624.2938560005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143555, + "strid": "d4aaef2e-6402-4844-b46a-ca08cc536171", + "image_id": 206080, + "image_name": "17355.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 111.309, + 3449.531, + 765.008, + 843.5219999999999 + ], + "priority": 18, + "parents": [ + 143576 + ], + "children": [], + "area": 383963.846079, + "iscrowd": 0, + "segmentation": [], + "text": "Ensembl has laid its foundations on Perl\nand MySQL, running the eHive workflows\non a LSF cluster. We are continuously\nincorporating faster technologies into our\ninfrastructure to scale further. For instance,\nregular updates to our GOC analysis over\nthe last four years have made it 2,850\nfaster. Processing homologies off a Lustre\nfile system instead of the MySQL database\nyielded a 5-fold speedup, saving 14 days of\ncompute off the gene-tree reconstruction\npipeline.\n\nThe technology radar on the right lists\nvarious alternatives we are exploring,\ngrouped by topic, and arranged according\nto their adoption status (used in production,\nunder trial, being assessed for future trial,\nor even deprecated)." + }, + { + "id": 143571, + "strid": "8955a746-5274-4b0d-8a8d-48961754571b", + "image_id": 206080, + "image_name": "17355.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 935.678, + 3435.656, + 938.1170000000001, + 858.8980000000001 + ], + "priority": 19, + "parents": [ + 143576 + ], + "children": [], + "area": 3214667.734768, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143558, + "strid": "2cc166c1-9aa2-4c64-8810-87c681613163", + "image_id": 206080, + "image_name": "17355.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1957.821, + 2273.94, + 1286.149, + 111.22600000000011 + ], + "priority": 20, + "parents": [ + 143576 + ], + "children": [], + "area": 4451967.48474, + "iscrowd": 0, + "segmentation": [], + "text": "Gene tree reconstruction at scale. we are planning\nto move to a divide and conquer approach to reconstruct our gene trees ." + }, + { + "id": 143572, + "strid": "d4c521f1-8d67-467f-a6c8-2c3f8931b86d", + "image_id": 206080, + "image_name": "17355.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1974.018, + 2421.838, + 551.4360000000001, + 1279.049 + ], + "priority": 21, + "parents": [ + 143576 + ], + "children": [], + "area": 4780751.805084, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143573, + "strid": "0f2c1809-0a0d-45ec-8d2a-b8f36ec6681c", + "image_id": 206080, + "image_name": "17355.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2588.75, + 2418.855, + 559.4079999999999, + 587.2570000000001 + ], + "priority": 22, + "parents": [ + 143576 + ], + "children": [], + "area": 6261810.88125, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143574, + "strid": "6db61a82-b8a6-4042-a431-6a378294b6c1", + "image_id": 206080, + "image_name": "17355.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2572.675, + 3056.465, + 634.319, + 509.7669999999998 + ], + "priority": 23, + "parents": [ + 143576 + ], + "children": [], + "area": 7863291.093875001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143556, + "strid": "10c6a2cc-e895-498a-8f91-8a2b78318c08", + "image_id": 206080, + "image_name": "17355.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1957.885, + 3784.237, + 1291.07, + 301.90099999999984 + ], + "priority": 24, + "parents": [ + 143576 + ], + "children": [], + "area": 7409100.858745, + "iscrowd": 0, + "segmentation": [], + "text": "Whole genome alignments at scale. cactus is in\ndevelopment to be tuned it to our computer clusters and to be used as\nstandard in our comparative analysis pipelines. Cactus provides the ability\nto iteratively add a genome to an existing alignment. The results will be\ncompared to our current multiple WGA pipelines and eventually replace\nWGAs where improvement is detected." + }, + { + "id": 143557, + "strid": "13737c61-79c5-4e39-aa6e-5dea121590d2", + "image_id": 206080, + "image_name": "17355.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1956.109, + 4151.846, + 1289.2940000000003, + 255.72800000000007 + ], + "priority": 25, + "parents": [ + 143576 + ], + "children": [], + "area": 8121463.327213999, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion. the improvement of the comparative analyses\nimplemented by Ensembl over the time has enable the comparison of over\n1700 genomes four times a year. We are now continuing further those\nimprovements to enable the comparison of the 10s of thousands genomes\nexpected to be produces by large scale genomic projects such as DToL" + }, + { + "id": 185781, + "strid": "cbf82814-1bfa-4434-8e36-f335abcf06da", + "image_id": 207744, + "image_name": "8724.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 36.8, + 302.92, + 105.60000000000001, + 239.35999999999996 + ], + "priority": -1, + "parents": [], + "children": [ + 185765, + 185763, + 185767, + 185760, + 185772, + 185775, + 185778, + 185774, + 185759, + 185776, + 185780, + 185769, + 185771, + 185761, + 185779, + 185768, + 185777, + 185764, + 185758, + 185773, + 185770, + 185766, + 185762 + ], + "area": 11147.456, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 185758, + "strid": "f35aaee4-0e8e-4e66-85ae-ca2f31543994", + "image_id": 207744, + "image_name": "8724.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 203.381, + 351.58, + 2817.768, + 86.47300000000001 + ], + "priority": 1, + "parents": [ + 185781 + ], + "children": [], + "area": 71504.69198, + "iscrowd": 0, + "segmentation": [], + "text": "PROSITE, a database for domain and site detection and annotation" + }, + { + "id": 185759, + "strid": "3769dfde-ba2b-4989-85ef-db0a0788770a", + "image_id": 207744, + "image_name": "8724.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 197.054, + 467.581, + 2828.314, + 383.85800000000006 + ], + "priority": 2, + "parents": [ + 185781 + ], + "children": [], + "area": 92138.706374, + "iscrowd": 0, + "segmentation": [], + "text": "Christian J. A. Sigrist ', Edouard de Castro ', Béatrice A. Cuche ', Delphine Baratin ', Thierry Schuepbach ?,\nSébastien Moretti 2, Marco Pagni *, Sylvain Poux ', Nicole Redaschi ', Alan Bridge ', Lydie Bougueleret |,\nloannis Xenarios 19\n\n’ Swiss-Prot group, SIB Swiss Institute of Bioinformatics, 1 Michel Servet, 1211 Geneva 4, Switzerland\n\n2 Vital-IT group, SIB Swiss Institute of Bioinformatics, Quartier Sorge, Batiment Génopode, 1015 Lausanne, Switzerland\n3 University of Lausanne, 1015 Lausanne, Switzerland" + }, + { + "id": 185760, + "strid": "79a0b42f-7411-4eb3-9c6e-c89cc0e98fe4", + "image_id": 207744, + "image_name": "8724.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 104.254, + 912.602, + 1611.358, + 339.5659999999999 + ], + "priority": 3, + "parents": [ + 185781 + ], + "children": [], + "area": 95142.408908, + "iscrowd": 0, + "segmentation": [], + "text": "PROSITE is a resource for the identification and annotation of conserved\nregions in protein sequences. These regions are identified using two types of\nsignatures: patterns (regular expressions) that describe short sequence\nmotifs, often corresponding to functionally or structurally important residues,\nand generalized profiles (weight matrices) that describe protein families and\nmodular protein domains." + }, + { + "id": 185761, + "strid": "4896cd51-b93a-42fb-bcc4-16d2911167e5", + "image_id": 207744, + "image_name": "8724.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 104.254, + 1378.715, + 1611.358, + 105.45499999999993 + ], + "priority": 4, + "parents": [ + 185781 + ], + "children": [], + "area": 143736.55361, + "iscrowd": 0, + "segmentation": [], + "text": "PROSITE signatures are curated by experts based on the scientific literature\nand 3D structures which allows:" + }, + { + "id": 185772, + "strid": "a586434b-d17b-4774-8032-44ba61cd20a8", + "image_id": 207744, + "image_name": "8724.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 202.731, + 1498.377, + 1021.065, + 159.47199999999998 + ], + "priority": 5, + "parents": [ + 185781 + ], + "children": [], + "area": 303767.467587, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 185762, + "strid": "5667251b-9c66-4d29-b047-80b1e755bd57", + "image_id": 207744, + "image_name": "8724.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 108.472, + 1665.554, + 1611.358, + 111.7829999999999 + ], + "priority": 6, + "parents": [ + 185781 + ], + "children": [], + "area": 180665.973488, + "iscrowd": 0, + "segmentation": [], + "text": "PROSITE has recently been used to annotate the closely related domains of\nthe RB-Tent fold, containing notably the CULT domain which binds thalidomide." + }, + { + "id": 185763, + "strid": "c616577f-25ec-49d9-ab0e-f6932d8ebe5c", + "image_id": 207744, + "image_name": "8724.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1894.886, + 925.257, + 1282.3380000000002, + 569.459 + ], + "priority": 7, + "parents": [ + 185781 + ], + "children": [], + "area": 1753256.535702, + "iscrowd": 0, + "segmentation": [], + "text": "PROSITE signatures are linked to annotation rules\n(ProRules) that define protein sequence annotations (Such\nas active sites and ligand-binding residues) and the\nconditions under which they apply (for example requiring\nspecific amino acid residues). PROSITE signatures, together\nwith ProRules, are used for the annotation of domains and\nsequence features of UniProtKB/Swiss-Prot entries. The\nlatest version of PROSITE (release 20.124 of 09 March\n2016) contains 1309 patterns, 1152 profiles and 1151\nProRules and is accessible at http://prosite.expasy.org." + }, + { + "id": 185764, + "strid": "d4ec53d8-55a2-4162-a0d5-626a86808983", + "image_id": 207744, + "image_name": "8724.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 141.916, + 1896.049, + 1604.428, + 225.9760000000001 + ], + "priority": 8, + "parents": [ + 185781 + ], + "children": [], + "area": 269079.689884, + "iscrowd": 0, + "segmentation": [], + "text": "Relationship between members of the B-tent fold consisting of two four-stranded beta\\,\n\nmeanders packing at a roughly right angle and coordinating a zinc ion at their apex.\nThe thalidomide-binding domain of cereblon defines the CULT domain family and is a new member of the B-tent fold.\nLupas A.N., Zhu H., Korycinski M.\n\nPLoS Comput. Biol. (2015).\nThe families are clustered in CLANS according to their pairwise Blast P-values. The five domain families occupy the vertices of an" + }, + { + "id": 185765, + "strid": "3f2dcac3-2412-4d82-a51b-e742a2c33c5c", + "image_id": 207744, + "image_name": "8724.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 141.916, + 2125.038, + 420.315, + 28.623999999999796 + ], + "priority": 9, + "parents": [ + 185781 + ], + "children": [], + "area": 301576.892808, + "iscrowd": 0, + "segmentation": [], + "text": "approximately equilateral pyramid" + }, + { + "id": 185779, + "strid": "98b5c1cf-7606-469f-8ba6-7b7fe309a053", + "image_id": 207744, + "image_name": "8724.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 70.18, + 2141.24, + 1227.847, + 976.1770000000001 + ], + "priority": 10, + "parents": [ + 185781 + ], + "children": [], + "area": 150272.2232, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 185777, + "strid": "e6d68c56-4028-4ebd-bf61-c9c8936a7590", + "image_id": 207744, + "image_name": "8724.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1332.346, + 2225.13, + 846.5279999999998, + 669.2150000000001 + ], + "priority": 11, + "parents": [ + 185781 + ], + "children": [], + "area": 2964643.05498, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 185780, + "strid": "268ac881-87b0-447d-837b-d3349852a8f1", + "image_id": 207744, + "image_name": "8724.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1395.802, + 2906.855, + 721.017, + 193.00599999999986 + ], + "priority": 12, + "parents": [ + 185781 + ], + "children": [], + "area": 4057394.0227099997, + "iscrowd": 0, + "segmentation": [], + "text": "The CULT domain detected by the\nPROSITE signature PS51788 is shown\nin green on the 3D structure of Human\n\nCereblon (4TZ4)." + }, + { + "id": 185771, + "strid": "081624f1-33e6-479d-91c6-3fcc1f14d5d9", + "image_id": 207744, + "image_name": "8724.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1862.128, + 1849.393, + 390.7070000000001, + 163.45900000000006 + ], + "priority": 13, + "parents": [ + 185781 + ], + "children": [], + "area": 3443806.488304, + "iscrowd": 0, + "segmentation": [], + "text": "Annotation rule for\nthe CULT domain\n(PRU01124)" + }, + { + "id": 185778, + "strid": "f862f4dd-5120-4d50-8ad8-b9813b7bdaa8", + "image_id": 207744, + "image_name": "8724.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2262.764, + 1668.404, + 985.71, + 890.3800000000001 + ], + "priority": 14, + "parents": [ + 185781 + ], + "children": [], + "area": 3775204.5086560003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 185770, + "strid": "d26ae6f0-381f-4d33-a1c5-a1849b642f15", + "image_id": 207744, + "image_name": "8724.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2381.726, + 2590.032, + 723.902, + 90.01900000000023 + ], + "priority": 15, + "parents": [ + 185781 + ], + "children": [], + "area": 6168746.555232001, + "iscrowd": 0, + "segmentation": [], + "text": "ScanProsite result for Human Cereblon\n(CRBN_HUMAN;: Q96SW2)" + }, + { + "id": 185776, + "strid": "f849bdea-3913-4c7e-a329-47bca2f9dd86", + "image_id": 207744, + "image_name": "8724.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2245.605, + 2684.619, + 1008.5889999999999, + 968.5499999999997 + ], + "priority": 16, + "parents": [ + 185781 + ], + "children": [], + "area": 6028593.849495, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 185767, + "strid": "d31e60a2-e634-43f8-bb67-7a1cf4e3d577", + "image_id": 207744, + "image_name": "8724.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 597.422, + 3242.894, + 1085.431, + 54.465999999999894 + ], + "priority": 17, + "parents": [ + 185781 + ], + "children": [], + "area": 1937376.219268, + "iscrowd": 0, + "segmentation": [], + "text": "This form allows you to scan proteins for matches against the PROSITE collection of motifs as well as against your own\npatterns." + }, + { + "id": 185773, + "strid": "7e47cacc-9548-4c27-af4a-d2d3a42e77cb", + "image_id": 207744, + "image_name": "8724.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 604.802, + 3303.369, + 887.8939999999999, + 73.99099999999999 + ], + "priority": 18, + "parents": [ + 185781 + ], + "children": [], + "area": 1997884.177938, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 185766, + "strid": "8550bdda-a79c-482c-aa2f-024373b00594", + "image_id": 207744, + "image_name": "8724.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 66.093, + 3449.824, + 529.192, + 687.7980000000002 + ], + "priority": 19, + "parents": [ + 185781 + ], + "children": [], + "area": 228009.217632, + "iscrowd": 0, + "segmentation": [], + "text": "Users can submit one or\nseveral sequences to scan\nagainst PROSITE\nsignatures and/or their own\npattern. A protein database\ncan also be uploaded for\nulterior scans against\nPROSITE and/or personal\nsignatures. The scan is\ndone at high speed using\nthe Vital-IT infrastructure as\nwell as a code acceleration\nand heuristic (pfsearchV3).\nprosite.expasy.org/scanprosite/" + }, + { + "id": 185774, + "strid": "23432b61-ce72-4b0e-b8c5-441fab902c83", + "image_id": 207744, + "image_name": "8724.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 602.12, + 3420.565, + 1039.094, + 951.3910000000001 + ], + "priority": 20, + "parents": [ + 185781 + ], + "children": [], + "area": 2059590.5978, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 185768, + "strid": "69fda979-b4c7-4f2c-90b3-fcb3913f1938", + "image_id": 207744, + "image_name": "8724.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1729.539, + 3302.547, + 448.6969999999999, + 328.09299999999985 + ], + "priority": 21, + "parents": [ + 185781 + ], + "children": [], + "area": 5711883.835833, + "iscrowd": 0, + "segmentation": [], + "text": "The PROSITE profile\nwith its associated\nProRule allows the\nevaluation of\nfeatures associated\nwith the domain." + }, + { + "id": 185769, + "strid": "43005922-1b2f-49d5-af35-08daa0d8eb5e", + "image_id": 207744, + "image_name": "8724.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1867.839, + 3774.26, + 1314.455, + 87.11599999999999 + ], + "priority": 22, + "parents": [ + 185781 + ], + "children": [], + "area": 7049710.02414, + "iscrowd": 0, + "segmentation": [], + "text": "Generated annotation for Human Cereblon (CRBN_HUMAN; Q96SW2)\nin UniProtKB/Swiss-Prot" + }, + { + "id": 185775, + "strid": "0129bdb0-c9fa-4f26-a999-12a97ee462f8", + "image_id": 207744, + "image_name": "8724.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1782.303, + 3855.269, + 1487.144, + 472.8359999999998 + ], + "priority": 23, + "parents": [ + 185781 + ], + "children": [], + "area": 6871257.504507, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 144665, + "strid": "df331eb9-643c-4a25-92f8-a2a208179de0", + "image_id": 206119, + "image_name": "18089.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 71.04, + 101.75, + 79.24999999999999, + 148.59 + ], + "priority": -1, + "parents": [], + "children": [ + 144648, + 144644, + 144662, + 144652, + 144655, + 144643, + 144647, + 144661 + ], + "area": 7228.320000000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 144643, + "strid": "4c7d4dc2-50d2-4a7c-9c66-7c888316bea5", + "image_id": 206119, + "image_name": "18089.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 195.911, + 86.794, + 2902.705, + 221.29500000000002 + ], + "priority": 1, + "parents": [ + 144665 + ], + "children": [], + "area": 17003.899333999998, + "iscrowd": 0, + "segmentation": [], + "text": "Exploration of enhancer-promoter interactions and their transcription\nfactor networks using topic modelling" + }, + { + "id": 144644, + "strid": "9aeb22e1-dc3b-483d-a506-18b7a850f0c1", + "image_id": 206119, + "image_name": "18089.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 158.549, + 377.064, + 3000.42, + 178.18599999999998 + ], + "priority": 2, + "parents": [ + 144665 + ], + "children": [], + "area": 59783.120136000005, + "iscrowd": 0, + "segmentation": [], + "text": "Dennis Hecker!23, Nina Baumgarten?? and Marcel H. Schulz?\n\n‘Institute for Cardiovascular Regeneration, Goethe University Hospital, 60590 Frankfurt am Main, Germany, 2Cardio-Pulmonary Institute, Goethe University Hospital, 60590 Frankfurt am Main, Germany, ?German Center for\nCardiovascular Research, Partner site Rhein-Main, 60590 Frankfurt am Main, Germany" + }, + { + "id": 144647, + "strid": "d26e5f8f-1955-4bf4-928f-430e1a6f9c6b", + "image_id": 206119, + "image_name": "18089.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 79.625, + 617.074, + 439.3109999999999, + 93.09900000000005 + ], + "priority": 3, + "parents": [ + 144665 + ], + "children": [ + 144646, + 144645 + ], + "area": 49134.51725, + "iscrowd": 0, + "segmentation": [], + "text": "Motivation" + }, + { + "id": 144645, + "strid": "7f3c53e3-7892-434f-92ac-a836308674fb", + "image_id": 206119, + "image_name": "18089.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 82.535, + 721.811, + 1573.955, + 741.8829999999999 + ], + "priority": 4, + "parents": [ + 144647 + ], + "children": [], + "area": 59574.670885, + "iscrowd": 0, + "segmentation": [], + "text": "Advances in epigenomics have highlighted the importance of non-coding regions in\nthe DNA for regulation of gene expression. Key players in gene regulation are\nenhancers. They can be located far away from their target genes and affect gene\nexpression by serving as transcription factor (TFs) binding sites. A gene’s promoter is\nalso bound by TFs which form protein complexes together with the associated\nenhancer-bound TFs to govern gene expression.\n\nWe applied topic modelling using Latent Dirichlet Allocation (LDA) on the predicted\nTF binding sites in enhancers and gene promoters of regulatory connections to\nexplore whether enhancer-promoter interactions can be characterized by their TFs.\nAlthough topic modelling has been applied to TF binding before, we follow a different\napproach by taking both sides of the interaction into account, the enhancer-bound\nTFs as well as the promoter-bound TFs. This separation could help to describe the\nformation of regulatory interactions, as we know whether a TF was predicted to bind\nin the enhancer or the promoter region." + }, + { + "id": 144646, + "strid": "fa8e49fa-2ecc-45b1-a6fe-6f952ebbaa67", + "image_id": 206119, + "image_name": "18089.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1682.673, + 640.349, + 1550.68, + 628.418 + ], + "priority": 5, + "parents": [ + 144647 + ], + "children": [], + "area": 1077497.972877, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 144648, + "strid": "0d334a70-316e-4da3-bd22-4081c8713038", + "image_id": 206119, + "image_name": "18089.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 86.275, + 1499.021, + 1221.924, + 193.26299999999992 + ], + "priority": 6, + "parents": [ + 144665 + ], + "children": [ + 144650, + 144651, + 144649 + ], + "area": 129328.036775, + "iscrowd": 0, + "segmentation": [], + "text": "ABC-score to identify promoter-\nenhancer connections" + }, + { + "id": 144649, + "strid": "ca02690d-6159-49a8-8164-977b36fd85ed", + "image_id": 206119, + "image_name": "18089.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 80.041, + 1717.222, + 1431.812, + 369.9019999999998 + ], + "priority": 7, + "parents": [ + 144648 + ], + "children": [], + "area": 137448.166102, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 144650, + "strid": "963e956b-cdfb-45a6-a861-a0aa76154974", + "image_id": 206119, + "image_name": "18089.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 77.963, + 2114.139, + 1610.529, + 371.98 + ], + "priority": 8, + "parents": [ + 144648 + ], + "children": [], + "area": 164824.618857, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 144651, + "strid": "feff480b-3ef8-44dd-92ea-fbe507ac66bf", + "image_id": 206119, + "image_name": "18089.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 86.275, + 2498.588, + 1550.264, + 91.43600000000015 + ], + "priority": 9, + "parents": [ + 144648 + ], + "children": [], + "area": 215565.67970000004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 144655, + "strid": "bb19028d-ca6c-47b8-bf57-cafede171da6", + "image_id": 206119, + "image_name": "18089.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1696.804, + 1499.021, + 1001.645, + 74.8119999999999 + ], + "priority": 10, + "parents": [ + 144665 + ], + "children": [ + 144654, + 144656 + ], + "area": 2543544.828884, + "iscrowd": 0, + "segmentation": [], + "text": "Construct TF count matrix" + }, + { + "id": 144654, + "strid": "ceac631a-6597-4bed-8bc4-69eac5b5fdd2", + "image_id": 206119, + "image_name": "18089.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1686.414, + 1598.77, + 1504.546, + 280.54399999999987 + ], + "priority": 11, + "parents": [ + 144655 + ], + "children": [], + "area": 2696188.1107799998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 144656, + "strid": "a672c878-b510-40ac-9220-f319d1784af3", + "image_id": 206119, + "image_name": "18089.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1713.429, + 1960.36, + 1336.2200000000003, + 583.9469999999999 + ], + "priority": 12, + "parents": [ + 144655 + ], + "children": [], + "area": 3358937.67444, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 144652, + "strid": "e6cf9c69-4e4d-40d9-91f4-76e51863d2d8", + "image_id": 206119, + "image_name": "18089.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 86.275, + 2614.962, + 974.63, + 103.9050000000002 + ], + "priority": 13, + "parents": [ + 144665 + ], + "children": [ + 144660, + 144657, + 144653 + ], + "area": 225605.84655000002, + "iscrowd": 0, + "segmentation": [], + "text": "Topic modelling with LDA" + }, + { + "id": 144653, + "strid": "1a0e2b15-62fd-4287-9384-9e74aed93dfb", + "image_id": 206119, + "image_name": "18089.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 82.119, + 2731.336, + 1548.186, + 590.181 + ], + "priority": 14, + "parents": [ + 144652 + ], + "children": [], + "area": 224294.58098399997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 144660, + "strid": "eb0e405e-aa7f-448f-a6f0-922f0c7ca630", + "image_id": 206119, + "image_name": "18089.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 125.957, + 3322.648, + 945.3949999999999, + 703.3029999999999 + ], + "priority": 15, + "parents": [ + 144652 + ], + "children": [ + 144658 + ], + "area": 418510.774136, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 144658, + "strid": "62c50e7e-58a8-4b27-b126-1b709e652fda", + "image_id": 206119, + "image_name": "18089.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 981.937, + 3855.589, + 694.0860000000001, + 153.7800000000002 + ], + "priority": 16, + "parents": [ + 144660 + ], + "children": [], + "area": 3785945.495893, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 2 Example String network of the top 5 ranked\nTFs in topic O. String set to a maximum of 10\ninteractors in the 1% shell. The model was trained\non K562 data." + }, + { + "id": 144657, + "strid": "56022810-8344-4204-9e05-bdf1a35a63fb", + "image_id": 206119, + "image_name": "18089.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1854.74, + 2598.337, + 1248.939, + 1315.4389999999999 + ], + "priority": 17, + "parents": [ + 144652 + ], + "children": [ + 144659 + ], + "area": 4819239.56738, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 144659, + "strid": "214a8402-2dde-4676-9780-f4d7cf4f1a86", + "image_id": 206119, + "image_name": "18089.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1721.742, + 3917.932, + 1501.959, + 76.76299999999992 + ], + "priority": 18, + "parents": [ + 144657 + ], + "children": [], + "area": 6745668.077543999, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 3 Top 8 TFs for each topic ranked by their topic importance. ‘e_’ refers to the TFs binding in the enhancer\nand ‘p_’ to the TFs binding in the promoter. The model was trained on K562 data." + }, + { + "id": 144661, + "strid": "93915577-cf81-4970-b30f-0a037708bee1", + "image_id": 206119, + "image_name": "18089.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 88.848, + 4045.389, + 341.049, + 84.81999999999971 + ], + "priority": 19, + "parents": [ + 144665 + ], + "children": [ + 144663 + ], + "area": 359424.721872, + "iscrowd": 0, + "segmentation": [], + "text": "Outlook:" + }, + { + "id": 144663, + "strid": "4c8d6a01-fa7c-47cc-8b85-cb7af0a3477c", + "image_id": 206119, + "image_name": "18089.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 154.231, + 4144.346, + 1420.743, + 309.241 + ], + "priority": 20, + "parents": [ + 144661 + ], + "children": [], + "area": 639186.6279259999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 144662, + "strid": "6795f560-5d27-4b34-a8f1-91df7e2a77f5", + "image_id": 206119, + "image_name": "18089.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1702.205, + 4041.855, + 450.6089999999999, + 84.82000000000016 + ], + "priority": 21, + "parents": [ + 144665 + ], + "children": [ + 144664 + ], + "area": 6880065.790275, + "iscrowd": 0, + "segmentation": [], + "text": "References:" + }, + { + "id": 144664, + "strid": "7d8cee4d-2a20-4845-90e2-5bbb9475e662", + "image_id": 206119, + "image_name": "18089.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1688.068, + 4153.182, + 1512.6319999999998, + 243.85900000000038 + ], + "priority": 22, + "parents": [ + 144662 + ], + "children": [], + "area": 7010853.632375999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 165524, + "strid": "2c27a100-082c-495f-bf30-c3a346f67ad1", + "image_id": 206957, + "image_name": "6706.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 326.55, + 41.6, + 248.07999999999998, + 67.03999999999999 + ], + "priority": -1, + "parents": [], + "children": [ + 165498, + 165502, + 165504, + 165503, + 165500, + 165501, + 165499, + 165518 + ], + "area": 13584.480000000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 165498, + "strid": "3fde4bae-fa7c-46b6-a765-571641d9e489", + "image_id": 206957, + "image_name": "6706.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 505.082, + 134.306, + 2303.294, + 260.131 + ], + "priority": 1, + "parents": [ + 165524 + ], + "children": [], + "area": 67835.543092, + "iscrowd": 0, + "segmentation": [], + "text": "Contrast detection differences between\ndichromats and trichromats" + }, + { + "id": 165499, + "strid": "72a2ea58-341e-4e86-9632-ca59cb304aa8", + "image_id": 206957, + "image_name": "6706.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 642.113, + 472.953, + 2054.063, + 133.42100000000005 + ], + "priority": 2, + "parents": [ + 165524 + ], + "children": [], + "area": 303689.26968900004, + "iscrowd": 0, + "segmentation": [], + "text": "Lauren Welbourne, Johanna Gledhill, Victoria Wilkinson and Alex R. Wade\nDepartment of Psychology, University of York, York, UK" + }, + { + "id": 165500, + "strid": "2c013f14-812b-44c2-9d31-2788aea82576", + "image_id": 206957, + "image_name": "6706.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 663.979, + 675.93, + 408.3309999999999, + 64.39099999999996 + ], + "priority": 3, + "parents": [ + 165524 + ], + "children": [ + 165505 + ], + "area": 448803.32547, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 165505, + "strid": "f55f27be-85f1-427e-b6e0-352c985de1ac", + "image_id": 206957, + "image_name": "6706.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 187.993, + 798.068, + 1369.052, + 1078.546 + ], + "priority": 4, + "parents": [ + 165500 + ], + "children": [], + "area": 150031.197524, + "iscrowd": 0, + "segmentation": [], + "text": "Dichromats, who lack L or M cones, also lack a pre-cortical\nopponent channel (L-M). The consequences of this for\ncortical development are unclear.\n\nOne possiblilty is that more retinal and V1 neurons are\navailable to process achromatic signals in dichromats\ncompared to trichromats.\n\nThe advantage this has for dichromats would depend on\nthe reallocation of neurons across spatial and temporal\nfrequency channels and contrast sensitivities.\n\nNeuronal population sizes decrease with increasing\ncontrast'*, and correspond to decreasing contrast\ndetection thresholds. If additional neurons are allocated\nuniformly across the contrast sensitivity range, and if\ndiscrimination is noise-limited, then we would expect\ndetection thresholds for high contrasts to be most affected." + }, + { + "id": 165501, + "strid": "9ddf0fc6-f001-45a5-b677-fb9f7708cad3", + "image_id": 206957, + "image_name": "6706.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2246.851, + 677.815, + 437.43200000000024, + 76.31200000000001 + ], + "priority": 5, + "parents": [ + 165524 + ], + "children": [ + 165509, + 165508, + 165522, + 165523 + ], + "area": 1522949.3105650002, + "iscrowd": 0, + "segmentation": [], + "text": "Methodology" + }, + { + "id": 165508, + "strid": "85ca00e4-bf5a-4d21-a8e5-a673292698ef", + "image_id": 206957, + "image_name": "6706.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1758.984, + 798.635, + 888.6779999999999, + 501.04099999999994 + ], + "priority": 6, + "parents": [ + 165501 + ], + "children": [], + "area": 1404786.1868399999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 165523, + "strid": "fe614eeb-aae0-40ce-b241-5fb5705c6696", + "image_id": 206957, + "image_name": "6706.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2739.346, + 804.868, + 399.7449999999999, + 398.8850000000001 + ], + "priority": 7, + "parents": [ + 165501 + ], + "children": [ + 165512 + ], + "area": 2204811.936328, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 165512, + "strid": "d758c417-e675-4770-84b2-9ff72eed2f28", + "image_id": 206957, + "image_name": "6706.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2738.502, + 1217.141, + 400.19000000000005, + 113.6690000000001 + ], + "priority": 8, + "parents": [ + 165523 + ], + "children": [], + "area": 3333143.0627820003, + "iscrowd": 0, + "segmentation": [], + "text": "Fig 1. Example of 4AFC\ntask. Target is located in\nthe bottom left circle." + }, + { + "id": 165509, + "strid": "8891a788-e3d2-4cad-a715-d5c1a4a1e733", + "image_id": 206957, + "image_name": "6706.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1756.922, + 1342.976, + 562.8980000000001, + 531.97 + ], + "priority": 9, + "parents": [ + 165501 + ], + "children": [], + "area": 2359504.079872, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 165522, + "strid": "6ce977b8-b064-46d4-8d85-e943765de4ac", + "image_id": 206957, + "image_name": "6706.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2361.093, + 1374.827, + 812.3850000000002, + 398.885 + ], + "priority": 10, + "parents": [ + 165501 + ], + "children": [ + 165513 + ], + "area": 3246094.405911, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 165513, + "strid": "663d8a74-b0f6-4478-b678-e8f24a0c08da", + "image_id": 206957, + "image_name": "6706.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2362.87, + 1788.037, + 809.9090000000001, + 77.16599999999994 + ], + "priority": 11, + "parents": [ + 165522 + ], + "children": [], + "area": 4224898.98619, + "iscrowd": 0, + "segmentation": [], + "text": "Fig 2. Pedestal levels for each condition. Contrast\nlevel (%) shown in the top left of each image." + }, + { + "id": 165502, + "strid": "24dc2352-8093-4830-9d93-6cad3ae522d7", + "image_id": 206957, + "image_name": "6706.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1534.35, + 1964.033, + 256.895, + 61.58400000000006 + ], + "priority": 12, + "parents": [ + 165524 + ], + "children": [ + 165506, + 165521, + 165510, + 165517 + ], + "area": 3013514.03355, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 165521, + "strid": "4edc16d4-f5dd-47ac-9157-02a3c842c1bb", + "image_id": 206957, + "image_name": "6706.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 133.391, + 2063.329, + 1826.909, + 1218.716 + ], + "priority": 13, + "parents": [ + 165502 + ], + "children": [ + 165514 + ], + "area": 275229.518639, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 165514, + "strid": "eb52e701-b2a7-4c20-9e7d-0fa44b3bd396", + "image_id": 206957, + "image_name": "6706.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 172.885, + 3300.334, + 1765.396, + 121.1550000000002 + ], + "priority": 14, + "parents": [ + 165521 + ], + "children": [], + "area": 570578.24359, + "iscrowd": 0, + "segmentation": [], + "text": "Fig 3. Histograms for each contrast pedestal (%) of 10,000 bootstrapped means for each of the colour vision groups:\ndichromats (blue) and trichromats (orange). The overlap of the distributions is shown in dark orange, and the\npercentage overlap of the distributions is given in the top left for each pedestal condition." + }, + { + "id": 165506, + "strid": "9bdeca2c-5c76-4323-8c31-f4b0522eaa45", + "image_id": 206957, + "image_name": "6706.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2053.306, + 2061.699, + 1075.286, + 200.74699999999984 + ], + "priority": 15, + "parents": [ + 165502 + ], + "children": [], + "area": 4233298.926894, + "iscrowd": 0, + "segmentation": [], + "text": "Bootstrapped means (Fig 3) were calculated\nfrom actual thresholds (Fig 4) of all dichromats\nand trichromats at each pedestal contrast." + }, + { + "id": 165510, + "strid": "7e8dfd7f-31d9-4e2c-b4a8-f6b6fe259515", + "image_id": 206957, + "image_name": "6706.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2053.333, + 2295.295, + 1097.312, + 460.692 + ], + "priority": 16, + "parents": [ + 165502 + ], + "children": [], + "area": 4713004.968235, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 165517, + "strid": "6a7dc47f-791e-41cf-810d-f83b232c2715", + "image_id": 206957, + "image_name": "6706.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2141.593, + 2816.929, + 841.683, + 464.1840000000002 + ], + "priority": 17, + "parents": [ + 165502 + ], + "children": [ + 165515 + ], + "area": 6032715.427897, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 165515, + "strid": "b2159e75-b00b-434a-8b39-e5c223594e61", + "image_id": 206957, + "image_name": "6706.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2011.499, + 3300.116, + 1158.803, + 121.29799999999977 + ], + "priority": 18, + "parents": [ + 165517 + ], + "children": [], + "area": 6638180.033884, + "iscrowd": 0, + "segmentation": [], + "text": "Fig 4. Average contrast detection thresholds (% constrast) for each pedestal\ncontrast condition (plotted on a log scale), for dichromats (blue) and\ntrichromats (orange). Error bars show +/- 1SE." + }, + { + "id": 165518, + "strid": "dc372d26-ab2d-4d46-8d9a-bd15385fb9ff", + "image_id": 206957, + "image_name": "6706.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1464.814, + 3501.17, + 377.4480000000001, + 60.08100000000013 + ], + "priority": 19, + "parents": [ + 165524 + ], + "children": [ + 165519, + 165520 + ], + "area": 5128562.8323800005, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 165519, + "strid": "04fe0901-5875-4c0a-892e-40d14c738e8a", + "image_id": 206957, + "image_name": "6706.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 157.868, + 3609.967, + 1425.479, + 499.605 + ], + "priority": 20, + "parents": [ + 165518 + ], + "children": [], + "area": 569898.270356, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 165520, + "strid": "f6b71773-7db5-4265-9187-ffa576437a6d", + "image_id": 206957, + "image_name": "6706.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1815.825, + 3591.501, + 1189.8209999999997, + 457.1930000000002 + ], + "priority": 21, + "parents": [ + 165518 + ], + "children": [ + 165516 + ], + "area": 6521537.303325, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 165516, + "strid": "9616ab31-abeb-4bb5-a846-b71b5ca2ceb3", + "image_id": 206957, + "image_name": "6706.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1726.122, + 4065.261, + 1411.5289999999998, + 78.72499999999991 + ], + "priority": 22, + "parents": [ + 165520 + ], + "children": [], + "area": 7017136.447842, + "iscrowd": 0, + "segmentation": [], + "text": "Fig 5. Hypothetical reallocation of ‘red-green’ tuned neurons in a dichromat (grey bars)\nshown on top of an example distribution of luminance-tuned cells in a trichromat (blue bars)." + }, + { + "id": 165503, + "strid": "44906949-47e7-4e50-b369-be65607c48e2", + "image_id": 206957, + "image_name": "6706.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 561.484, + 4212.949, + 612.823, + 61.49399999999969 + ], + "priority": 23, + "parents": [ + 165524 + ], + "children": [ + 165507 + ], + "area": 2365503.456316, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 165507, + "strid": "b87334bf-a94a-480c-a48d-f66e3aa4d169", + "image_id": 206957, + "image_name": "6706.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 205.966, + 4330.03, + 1323.2350000000001, + 190.9399999999996 + ], + "priority": 24, + "parents": [ + 165503 + ], + "children": [], + "area": 891838.95898, + "iscrowd": 0, + "segmentation": [], + "text": "Investigate whether the same effect is found for the\nS-cone isolating channel (using isoluminant “yellow-blue”\nstimuli across multiple contrast pedestal levels)." + }, + { + "id": 165504, + "strid": "e5c1612a-5a5b-4fa5-b917-2926f137d990", + "image_id": 206957, + "image_name": "6706.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2267.775, + 4212.243, + 407.8420000000001, + 62.20100000000002 + ], + "priority": 25, + "parents": [ + 165524 + ], + "children": [ + 165511 + ], + "area": 9552419.369325, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 165511, + "strid": "0dc433d5-1071-4d71-b42d-33c735c88ee3", + "image_id": 206957, + "image_name": "6706.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1806.412, + 4312.775, + 1324.6409999999998, + 210.84299999999985 + ], + "priority": 26, + "parents": [ + 165504 + ], + "children": [], + "area": 7790648.5133, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 20622, + "strid": "37b233a8-3d93-4368-ba6e-1fae03833da7", + "image_id": 201312, + "image_name": "116917.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 7.49, + 20.95, + 37.1, + 78.58 + ], + "priority": -1, + "parents": [], + "children": [ + 20607, + 20608, + 20611, + 20621, + 20610, + 20609, + 20620 + ], + "area": 156.9155, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 20607, + "strid": "4154ac81-a36b-43b0-905d-a87fe8d494eb", + "image_id": 201312, + "image_name": "116917.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 49.394, + 24.072, + 515.54, + 50.72099999999999 + ], + "priority": 1, + "parents": [ + 20622 + ], + "children": [], + "area": 1189.012368, + "iscrowd": 0, + "segmentation": [], + "text": "PG Ns istr Vea tthe eco Cast ee CRTC Re tC es\ninside a psychotherapeutic relation" + }, + { + "id": 20608, + "strid": "711d5c60-a697-4b14-b110-20cd62566033", + "image_id": 201312, + "image_name": "116917.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 50.51, + 83.769, + 253.23400000000004, + 77.44900000000001 + ], + "priority": 2, + "parents": [ + 20622 + ], + "children": [], + "area": 4231.17219, + "iscrowd": 0, + "segmentation": [], + "text": "aa ee\n\nea\nSo renee eC (Egeahe a\nSeer eee\n\nMPG URC E teer ll" + }, + { + "id": 20609, + "strid": "fe213c31-b9cd-4136-9106-5b08ad1932e3", + "image_id": 201312, + "image_name": "116917.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 106.448, + 191.179, + 173.084, + 21.144000000000005 + ], + "priority": 3, + "parents": [ + 20622 + ], + "children": [ + 20612 + ], + "area": 20350.622192, + "iscrowd": 0, + "segmentation": [], + "text": "Intrenuction" + }, + { + "id": 20612, + "strid": "52336031-ec19-4439-a0b7-5245a81dd25a", + "image_id": 201312, + "image_name": "116917.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 86.522, + 219.638, + 211.046, + 295.155 + ], + "priority": 4, + "parents": [ + 20609 + ], + "children": [], + "area": 19003.519036, + "iscrowd": 0, + "segmentation": [], + "text": "Accordiagtadp ancient beliel the hee-\nling propertivs of humour have very au-\ncient dete If it wos trne for the past ~\neves sil wot all scientists have been\nrumpathetic towards the study of the\n\nGipinavined the langhtarta goseral = tt\n\n \n\nhas @ greater value at prerent days,\nwhere the health often matches with «\nfooling of well-being not only referred\nte the \"bios\", but also ta the paychalog:-\ngal aad social spheres,\n\nMy work, although, ts a rollection act\nsimply on how and how mach the comic\nmental side has advantageous potenti\nIntier for the individyal's health, bat\nmore Ia particular for the humour\nthet nadowbtedly” belongs td\n‘comie” mental\n\nshares the advantageous pecnliarities\nmentionddrahove - and for the relation\ni has with the psychotherapeutic envi-" + }, + { + "id": 20610, + "strid": "5d9df81d-a1e9-43f0-a064-8c2ca067b88b", + "image_id": 201312, + "image_name": "116917.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 123.298, + 539.79, + 140.248, + 19.32899999999995 + ], + "priority": 5, + "parents": [ + 20622 + ], + "children": [ + 20613, + 20614, + 20616, + 20618, + 20615 + ], + "area": 66555.02742, + "iscrowd": 0, + "segmentation": [], + "text": "Argument" + }, + { + "id": 20613, + "strid": "d5f1a148-7533-445e-96e4-4eccfc01571c", + "image_id": 201312, + "image_name": "116917.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 85.761, + 566.736, + 212.739, + 440.429 + ], + "priority": 6, + "parents": [ + 20610 + ], + "children": [], + "area": 48603.846095999994, + "iscrowd": 0, + "segmentation": [], + "text": "Departing point for my reflection waa\n\nthe question whether any kind of “ther.\n\npentie” humour might get some space\nrd siguilicance inside a thpebpSatic n\n\n \n\n \n\nlation 10 that it could hevtonsidered 0\nUerepentis tustrument qual « brawale\n\n \n\nmation factor,\nIf the humour, sith) all ite complexity\nthat makes it hotha mechs\n\nse /protection and ax ‘import\n\n \n\nism of det\n\n \n\n \n\n+ coping\nclement, js'ane of the mainstay my work\nis based on, the other topie to he taken\n\nteclepiderat\n\n \n\nyt the prgebntlns\n\n \n\nAs everybody knows, it dees not exist\n‘tke” psychotherapy, but different set-\nlings ~ therelore, different sets aad theo-\nretical and methodological (rames\nthrough which it can take place -a\nachtove a fulfillment\nDeliberately. in ma work, [do nat roler to\na specific way of conducting 4 paycho-\ntherepy, but I irted to-etplure and go\nthrough various fields, comsidering the\niqutty” axpoct of langhter aad\n\n \n\n \n\n \n\n \n\n \n\n \n\nbamout; thet rendh@Abens comma phe\n\n \n \n\nnomene to every men’s life\nThe following consideration, thea, has\nbees orgesized oa lwo fusdame\n\ncopts for tho psychotherapy attitude, In\norder ta establish some lendmarkes: the\n\n \n\n \n\nexe Seusing on the situation aud the\nSaber focusing on the process." + }, + { + "id": 20614, + "strid": "122e3e9f-b4de-44de-a8fe-5f509db915b0", + "image_id": 201312, + "image_name": "116917.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 84.958, + 1024.627, + 212.40899999999996, + 102.519 + ], + "priority": 7, + "parents": [ + 20610 + ], + "children": [], + "area": 87050.26066599999, + "iscrowd": 0, + "segmentation": [], + "text": "ty choth Utwatic\n\n \n\nThrough the analysis ofthe paychologicalbo-\nwith\nregard to the presonce aad fuaclich of the\noman i she piychotherapentic situation\nEven f rather late inthe if leginivation was\ninehdaiied, SMsals ta-seeiiebas. Vota Bees!\n\nrature some conlicting opiatoas om" + }, + { + "id": 20615, + "strid": "f713d4d2-902b-40ee-9401-7463e6faf5d9", + "image_id": 201312, + "image_name": "116917.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 314.698, + 314.044, + 212.913, + 474.07399999999996 + ], + "priority": 8, + "parents": [ + 20610 + ], + "children": [], + "area": 98829.01871199999, + "iscrowd": 0, + "segmentation": [], + "text": "“eed Pelee: ete very sowng ase Gaberelt\naod wore, on tho contrary, the objoctioas of\nse who excluded an eventual presence’ af\nhumour intide the therapeutic relat\nHe who is agetast the use of hemous taside the\nprychotheraps, like Kubie, jgtihed his ows\nviewpoint underlining the funetion of socal\nratios typical of the leugh ar well ex the fact\nthet is wight be asod at delonsive eittade, by\nsednee of altach the other, of even to check-\nmate the thesapeutte process. That would meas\nthat all the tsps typical of the tenslerence\nid eGgater-translerence aight be biddes\nbehinithe nse af hnmonr.\nly forthe husoer: the\nsherapiat cas, ia fact, bebave following his s2-\nistic or seductive tmpulror also boing silo,\n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\n \n\nBaths i wot dra\n\n \n\nhaving a clinical atttnde or without saying ®\nword. The soltion to the preblew, therelve, 8\nhe omelet\n\n \n\nany hemoritte peertbilty\n\n \n\n \n\nfrom the therapouticcelation,\nste the\n\nso thet i¢ ight be dose an use cousitent with\ntho therapeutic targot so a the base ofthe\n\n‘ts prosones,\n\n \n\nsary es)\n\n \n\nlation\nIf bumoae called s9tp action with awareness,\non the contrary, Ea futroduce ito the rela-\nsion the beneiiialstlets characterisie of the\nTanghs tagetheY” that ate a posible strong\nthoning éfhiho th\n\nsh ainie paint of view\nol te change owing to the\nMaliter peculiny to the Iaaghter, trom the\nSsorphooge é\n\ntie llience, fr\n\n \n\n \n\n \n\n fartheranee\n\n \n\nabrestive” pote" + }, + { + "id": 20616, + "strid": "7816168c-195e-4fd6-ba52-9407d477dc24", + "image_id": 201312, + "image_name": "116917.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 314.962, + 796.429, + 213.40200000000004, + 331.60800000000006 + ], + "priority": 9, + "parents": [ + 20610 + ], + "children": [], + "area": 250844.87069799998, + "iscrowd": 0, + "segmentation": [], + "text": "Considering the characteristics\ntransformative potentialities inmate in\nthe humorous phenomenon, the paycho-\n\n \n\ntherapist might sevionaly talke trto eon\nsideration an ute of it, beGQuse he could\ncither make of ita therapeutic tnstew\nment able to evaluate the improvement\nof the patient and promote a change ~\nnot of course with a counter-trans\n\nEach therapeutic path consists, in fact,\nof emascipation from the suffering con-\nUitron.end the prucholoatcal stalemate\nthatcon arise for a given degree of r\nlity, stereotyping, sepetitio\nthese are all conditions that the comig\n\n \n\n \n\n \n\n \n\ndows ww be\n\n \n\n1-5, tu full the ovulate\nof the patient Gy.\n\n \n \n \n\n2 about the\nbeing eoudicton\nthet it being taken iia therapy can\nbe coustdeved « predictiva elpment lor the\nvesult of the prgchetbaany’ the humour," + }, + { + "id": 20618, + "strid": "120de669-1fd8-4541-ab06-43217de2866f", + 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be\npagchotherapenticsteation into a superiicial\natniosphere sot prolestional anymore bul 6,\nJing to belittle For that reason 4 haa t@ be\n\n \n\n1 of the\ntion: if ii true that too much\n\n \n\n \n\n \n\na tration\n\n \n\n \n\n \n\n \n\n \n\ncusployed with good senso end gradual, ==\n(roduciag it ato the vetting st az bo used ac-\ntually considering tho\n\nthe methodelog\ntherapeuite path and the psychological seali-\nwebthesenbest" + }, + { + "id": 20620, + "strid": "915c7c8c-682a-4254-977e-dea0c6b52577", + "image_id": 201312, + "image_name": "116917.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 350.66, + 189.032, + 184.257, + 109.172 + ], + "priority": 11, + "parents": [ + 20622 + ], + "children": [], + "area": 66285.96112, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 20621, + "strid": "8a844ffd-02cd-4b8b-90da-14f606b88750", + "image_id": 201312, + "image_name": "116917.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 537.327, + 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and wenn uae ok fhe\nbg aba bas\n\ngoals ab (facilitates the recovery of the\nrood parts of the Sell, being thew linked\nta the patient cognitive or emotional area\nThe therapeutic potential t owas, lies 1x\nthe fact that 1t possesses the Instruments\nto get out of the innate dichotomy sch as\nni\" Togtes to get aceesi to the\nlogical “et-ot\", which Jot bave «\n\n \n\ntcad Far theenpanttn\n\n \n\n \n\n \n\nwider comprehension of the pagehic\nite different dimes\n\nAlves\nterpretation ~ the most gawerln] transfor\nmative instrament the therapist possesses\n- the capability to create naw links able\nto tie up symptom ond unconscious, post\n\n \n \n\n \n\n1d proscgtelationality\n\n \n\nhe reploditter, as for the interpretation,\nis act HPit’s ated oF aot, but the uso ome\na bat it" + }, + { + "id": 20619, + "strid": "8dc3bee6-1af1-4de1-a812-2003e085ded0", + "image_id": 201312, + "image_name": "116917.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 550.664, + 1006.519, 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Sle D, Voll M2005), Reorder\ndre acoe Bele Borage, Tras\n\nRenner A 908, Lae della eeiann Rd\nlakhs. Rena 079\n\nKable LS, (0H) “The Danes Pinto er\nts Prchthempt-tn An} Poychet vol\npochic.Froven Angel Milano\n\nSpine A: 2000} vee che i Sg india" + }, + { + "id": 69452, + "strid": "2665b8ed-856b-4600-b201-a856c018a055", + "image_id": 203214, + "image_name": "119871.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 241.9, + 548.41, + 159.23999999999998, + 205.69000000000005 + ], + "priority": -1, + "parents": [], + "children": [ + 69432, + 69430, + 69433, + 69431, + 69435, + 69434 + ], + "area": 132660.379, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 69430, + "strid": "b0fc79aa-1946-47dd-88b5-bcabffe690bf", + "image_id": 203214, + "image_name": "119871.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 487.117, + 486.448, + 2585.908, + 458.42600000000004 + ], + "priority": 1, + "parents": [ + 69452 + ], + "children": [], + "area": 236957.090416, + "iscrowd": 0, + "segmentation": [], + "text": "IMPACT OF INITIAL DIALYSIS MODALITY AND\nMODALITY SWITCHES ON PATIENT SURVIVAL:\nA COHORT STUDY" + }, + { + "id": 69431, + "strid": "e033c75d-fffa-4f9b-9bc5-8bcbb98e9553", + "image_id": 203214, + "image_name": "119871.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 206.25, + 993.299, + 3144.412, + 342.2049999999999 + ], + "priority": 2, + "parents": [ + 69452 + ], + "children": [], + "area": 204867.91874999998, + "iscrowd": 0, + "segmentation": [], + "text": "Boris Bikhov, Natalia Tomilina, Oleg-Kotenko, Anton Andrusev\n\n‘Chair of Nephrology, A.1.Evdokimov Moscow State University of-Medicine and Dentistry, Department of Nephrology Issues of\nTransplanted Kidney, Academician V.1.Shumakov Federal Research Center of Transplantology and Artificial Organs,\n3Moscow City Nephrology Center, Moscow City Hospital 52, Moscow, Russian Federation" + }, + { + "id": 69432, + "strid": "a7e07cae-e3ef-4925-b9b9-7a2e1323e1e6", + "image_id": 203214, + "image_name": "119871.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 86.219, + 1406.397, + 317.658, + 45.38000000000011 + ], + "priority": 3, + "parents": [ + 69452 + ], + "children": [ + 69440 + ], + "area": 121258.14294299998, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 69440, + "strid": "056fbdc3-6fcc-4927-89ff-09744d405db1", + "image_id": 203214, + "image_name": "119871.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 87.459, + 1468.163, + 1626.769, + 107.37300000000005 + ], + "priority": 4, + "parents": [ + 69432 + ], + "children": [], + "area": 128404.067817, + "iscrowd": 0, + "segmentation": [], + "text": "Survival of dialysis patients, depends on many factors. We investigatéd how the\ninitial dialysis modality and modality switches influence patients’ suftvival." + }, + { + "id": 69433, + "strid": "073ad907-f07a-4656-8379-12f5d211c278", + "image_id": 203214, + "image_name": "119871.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 87.06, + 1608.085, + 210.091, + 44.53899999999999 + ], + "priority": 5, + "parents": [ + 69452 + ], + "children": [ + 69439 + ], + "area": 139999.8801, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 69439, + "strid": "b2a7a6dc-b37d-422d-a80c-eedc0d452dfa", + "image_id": 203214, + "image_name": "119871.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 84.517, + 1671.142, + 1628.24, + 551.5719999999999 + ], + "priority": 6, + "parents": [ + 69433 + ], + "children": [], + "area": 141239.908414, + "iscrowd": 0, + "segmentation": [], + "text": "We performed:an‘analysis of the Moscow City Nephrology\\Registry with inclusion\nof 11,021 incident hemodialysis (HD) and peritoneal dialysis (PD) patients started\ntreatment from 1/1/1995 to 31/12/2012. We identified'4.groups according to initial\nmodality.and long-term transfer (duration>30 days)to another modality: HD only,\nPD only, initial HD with permanent switch to PD (HD->PD), initial PD with\npermanent switch to HD (PD->HD). Survival was calculated by Kaplan-Meier\nmethod with intent-to-treat approach (censoring at end study period, kidney\ntransplantation, or lost of follow-up).P) values were adjusted by Benjamini—\nHochberg—Yekutieli procedure for ‘controlling false discovery rate in multiply\ncomparisons." + }, + { + "id": 69434, + "strid": "fbe46a9f-8e30-46e9-bf3a-ea7ce09209f1", + "image_id": 203214, + "image_name": "119871.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 86.285, + 2252.549, + 187.76399999999998, + 43.14300000000003 + ], + "priority": 7, + "parents": [ + 69452 + ], + "children": [ + 69443, + 69442, + 69437, + 69441, + 69438, + 69448, + 69449, + 69450, + 69451 + ], + "area": 194361.190465, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 69438, + "strid": "5cac98a4-8dd5-4096-85b3-fe013cb1c0ec", + "image_id": 203214, + "image_name": "119871.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 81.576, + 2313.907, + 1626.769, + 108.84400000000005 + ], + "priority": 8, + "parents": [ + 69434 + ], + "children": [], + "area": 188759.277432, + "iscrowd": 0, + "segmentation": [], + "text": "Demographic data and duration of pre-dialysys nephrology care are,presented in\ntable 1, and results of survival analysis - in tables 2,3 and figure." + }, + { + "id": 69448, + "strid": "ed0cd4b9-3784-40c0-b8dc-ce0536fc39ca", + "image_id": 203214, + "image_name": "119871.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 87.745, + 2501.084, + 1624.9500000000003, + 441.7640000000001 + ], + "priority": 9, + "parents": [ + 69434 + ], + "children": [ + 69447 + ], + "area": 219457.61557999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 69447, + "strid": "87c67c30-12c1-4a41-8aa5-3d09b2e7473e", + "image_id": 203214, + "image_name": "119871.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 84.655, + 2436.21, + 1343.828, + 54.0619999999999 + ], + "priority": 10, + "parents": [ + 69448 + ], + "children": [], + "area": 206237.35755000002, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1. Demographics and duration of predialysis nephrology Care" + }, + { + "id": 69451, + "strid": "b33f065a-b12e-4419-96e5-44f3a8d7163a", + "image_id": 203214, + "image_name": "119871.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 82.243, + 2947.295, + 1627.212, + 66.48099999999977 + ], + "priority": 11, + "parents": [ + 69434 + ], + "children": [], + "area": 242394.382685, + "iscrowd": 0, + "segmentation": [], + "text": "HD — hemodialysis only, PD — peritoneal dialysis only, HD->PD = initial HD with permanent switch to PD, PD->HD - initial HD. with\npermanent switch to PD" + }, + { + "id": 69437, + "strid": "dc3649b7-884c-40a0-8979-8d39d6fb11e0", + "image_id": 203214, + "image_name": "119871.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 85.988, + 3027.273, + 1628.24, + 441.25700000000006 + ], + "priority": 12, + "parents": [ + 69434 + ], + "children": [], + "area": 260309.150724, + "iscrowd": 0, + "segmentation": [], + "text": "We found the highest survival during all 5 years of follow-up in patients switehed\nfrom PD to HD (P<0.00005).if comparison to all other groups (table 2\\and 3,\nfigure). Survival in PD only was higher than in HD only group in the first year of\ntreatment, there were norstatistically significant differences from 2 to.4 years, and\n5 year survival was ‘significantly lower in PD only patients. Possibility to switch\nmodality from PD to.HD was beneficial at the 5 years of follow-up (P<0.00005 in\ncomparison to PRD) only), while switching from HD to PD, gives advantage only\nduring first 2 years of treatment (P<0.00005 in comparison‘to HD only)." + }, + { + "id": 69441, + "strid": "f9f22ac4-8fb2-4f8c-84db-5b88f6034664", + "image_id": 203214, + "image_name": "119871.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1846.575, + 1464.911, + 1624.698, + 482.7819999999999 + ], + "priority": 13, + "parents": [ + 69434 + ], + "children": [ + 69446 + ], + "area": 2705068.029825, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 69446, + "strid": "5d9f7a48-c18d-4d1a-a7de-5cb4c8212824", + "image_id": 203214, + "image_name": "119871.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1849.495, + 1402.855, + 1548.734, + 51.878999999999905 + ], + "priority": 14, + "parents": [ + 69441 + ], + "children": [], + "area": 2594573.308225, + "iscrowd": 0, + "segmentation": [], + "text": "Table 2. Patient survival according initial dialysis modality and modality switch" + }, + { + "id": 69449, + "strid": "3df60e87-c165-4599-b72c-b7ac8b2c1733", + "image_id": 203214, + "image_name": "119871.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1843.957, + 1957.007, + 1624.7500000000002, + 98.51000000000022 + ], + "priority": 15, + "parents": [ + 69434 + ], + "children": [], + "area": 3608636.7566990005, + "iscrowd": 0, + "segmentation": [], + "text": "95% Cl — 95% confidence interval\nHD — hemodialysis only, PD — peritoneal dialysis only, HD->PD # initial HD with permanent switch to PD, PD->HD - initial HD with\npermanent switch to PD" + }, + { + "id": 69442, + "strid": "8e0e984d-4bfc-4da7-8bdf-bf1067de745a", + "image_id": 203214, + "image_name": "119871.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1841.572, + 2180.329, + 1629.7, + 380.2220000000002 + ], + "priority": 16, + "parents": [ + 69434 + ], + "children": [ + 69445 + ], + "area": 4015232.837188, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 69445, + "strid": "b27903f7-70ac-4f98-82cf-b7d2f5ddfea6", + "image_id": 203214, + "image_name": "119871.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1844.917, + 2123.054, + 1556.364, + 51.878999999999905 + ], + "priority": 17, + "parents": [ + 69442 + ], + "children": [], + "area": 3916858.416518, + "iscrowd": 0, + "segmentation": [], + "text": "Table 3. Statistical significance.ofdifferences in survival rates between groups" + }, + { + "id": 69450, + "strid": "ab3d9cfa-f51d-4b77-bfd8-7c0df953dce4", + "image_id": 203214, + "image_name": "119871.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1843.957, + 2567.766, + 1626.064, + 65.67300000000023 + ], + "priority": 18, + "parents": [ + 69434 + ], + "children": [], + "area": 4734850.090062001, + "iscrowd": 0, + "segmentation": [], + "text": "HD — hemodialysis, only, PD — peritoneal dialysis only, HD->PD — initial HD with permanent switch to PD, PD->HD - initial HD with\npermanent switch to PD" + }, + { + "id": 69443, + "strid": "9309537e-3f1d-4d8a-9611-60f1b4ddab7a", + "image_id": 203214, + "image_name": "119871.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1859.009, + 2766.861, + 1609.4989999999998, + 1150.402 + ], + "priority": 19, + "parents": [ + 69434 + ], + "children": [ + 69444 + ], + "area": 5143619.500748999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 69444, + "strid": "bd3fe2c2-390a-46ac-83ff-595539291c32", + "image_id": 203214, + "image_name": "119871.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1846.443, + 2707.454, + 1533.4759999999999, + 50.353000000000065 + ], + "priority": 20, + "parents": [ + 69443 + ], + "children": [], + "area": 4999159.486122, + "iscrowd": 0, + "segmentation": [], + "text": "Figure. Patient survival according initial dialysis. modality and modality switch" + }, + { + "id": 69435, + "strid": "99dc1a08-c18a-40e9-b3dc-c46e7e95c926", + "image_id": 203214, + "image_name": "119871.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 89.129, + 3519.798, + 306.54, + 47.159999999999854 + ], + "priority": 21, + "parents": [ + 69452 + ], + "children": [ + 69436 + ], + "area": 313716.075942, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 69436, + "strid": "8f42102b-d4c7-4f13-8eb2-0c474ff707a6", + "image_id": 203214, + "image_name": "119871.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 88.93, + 3584.728, + 1620.885, + 323.58899999999994 + ], + "priority": 22, + "parents": [ + 69435 + ], + "children": [], + "area": 318789.86104000005, + "iscrowd": 0, + "segmentation": [], + "text": "The ,highest survival was found in patients switched from PD to HD in all time\npoints among 4 groups. Possibility to switch from HD to PD provided benefits only\nin, the first two years of dialysis treatment\\PD only patients had better survival\nover HD only patients at the first year ofsdialysis, but worse survival at the fifth\nyear of follow-up. Our results suggestthat PD was the preferable initial dialysis\nmodality that could be later switche¢_to HD." + }, + { + "id": 183784, + "strid": "574763cc-c390-4772-a1ba-a9acc0de34bb", + "image_id": 207672, + "image_name": "8576.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 443.1, + 52.24, + 211.89, + 228.2 + ], + "priority": -1, + "parents": [], + "children": [ + 183770, + 183767, + 183769, + 183765, + 183777, + 183779, + 183771, + 183778, + 183768, + 183781, + 183780, + 183776, + 183764, + 183766, + 183782 + ], + "area": 23147.544, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 183764, + "strid": "5c6b1be8-cd6a-408c-a51e-0f885619a939", + "image_id": 207672, + "image_name": "8576.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 675.084, + 111.988, + 2244.64, + 235.346 + ], + "priority": 1, + "parents": [ + 183784 + ], + "children": [], + "area": 75601.306992, + "iscrowd": 0, + "segmentation": [], + "text": "SS SS SS" + }, + { + "id": 183765, + "strid": "581d4d18-a7b4-4697-9846-4f35a4f1f0d8", + "image_id": 207672, + "image_name": "8576.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 80.744, + 382.452, + 3452.741, + 368.04600000000005 + ], + "priority": 2, + "parents": [ + 183784 + ], + "children": [], + "area": 30880.704288, + "iscrowd": 0, + "segmentation": [], + "text": "Anirban Mandalt, Krishna Kumar Ganta?, Binay Chaubey?2\n\n1 Centre for Advance Studies, Department of Botany, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700019, INDIA\n* Department of Recombinant Vaccines, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk,\nKladki 24, 80-822 Gdansk, POLAND" + }, + { + "id": 183766, + "strid": "ac81eb6b-fc80-4277-9474-debf86c630a0", + "image_id": 207672, + "image_name": "8576.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 65.525, + 1009.846, + 108.214, + 3895.1120000000005 + ], + "priority": 3, + "parents": [ + 183784 + ], + "children": [], + "area": 66170.15915, + "iscrowd": 0, + "segmentation": [], + "text": "VIGNI ‘GVEVYSGAH “9TOZ SASVJSSIC SNOILDSINI NO SSAHYONOD IWNOILVNUYSLNI wZT" + }, + { + "id": 183767, + "strid": "c96f1a97-3d7d-4e47-943d-df992ad0fff6", + "image_id": 207672, + "image_name": "8576.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 279.805, + 895.197, + 393.52399999999994, + 44.605999999999995 + ], + "priority": 4, + "parents": [ + 183784 + ], + "children": [ + 183772 + ], + "area": 250480.59658500002, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 183772, + "strid": "47cb5175-6393-48e0-992b-8556f292b5b4", + "image_id": 207672, + "image_name": "8576.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 278.783, + 990.003, + 1309.6750000000002, + 394.764 + ], + "priority": 5, + "parents": [ + 183767 + ], + "children": [], + "area": 275996.00634900003, + "iscrowd": 0, + "segmentation": [], + "text": "Hepatitis C virus is a major cause of chronic liver diseases such as chronic\nhepatitis, liver cirrhosis and hepatocellular carcinoma. The present available anti-\nHCV drugs, pegylated interferon-a (IFN- a) and ribavirin have limited efficacy,\nresistance problems and high manufacturing cost. Among the newer approaches to\ncurb the viral replication, RNA interference (RNAi) based approaches have shown\n\ntremendous prospective to inhibit HCV replication." + }, + { + "id": 183768, + "strid": "07f922b9-b1a7-43a7-bcbb-3dce960bdc91", + "image_id": 207672, + "image_name": "8576.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 280.802, + 1463.589, + 607.244, + 43.374000000000024 + ], + "priority": 6, + "parents": [ + 183784 + ], + "children": [ + 183773 + ], + "area": 410978.718378, + "iscrowd": 0, + "segmentation": [], + "text": "MATERIALS & METHODS" + }, + { + "id": 183773, + "strid": "af46e474-fe9b-4988-a381-bf3902ca4225", + "image_id": 207672, + "image_name": "8576.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 276.654, + 1544.076, + 1313.096, + 468.22399999999993 + ], + "priority": 7, + "parents": [ + 183768 + ], + "children": [], + "area": 427174.801704, + "iscrowd": 0, + "segmentation": [], + "text": "pFL-J6/JFH vector was linearized with XbaI and subjected to in vitro transcription.\nThe HCV genomic replicon was transfected into Huh-7.5 cells for production of\ninfectious HCV particles. The culture supernatant was collected to infect naive\nHuh-7.5 cells. siRNAs were targeted against NS5B region of HCV genome as well\nas cellular factors, La autoantigen, PSMA7 and hVAP-A in order to down regulate\nHCV in cell culture model. Furthermore, multiple combinations of siRNAs were\n\nused to observe the additive HCV down regulation" + }, + { + "id": 183769, + "strid": "92c357f3-3ac4-403e-b86f-b9aa78b2a810", + "image_id": 207672, + "image_name": "8576.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 280.171, + 2064.548, + 233.71200000000005, + 41.39800000000014 + ], + "priority": 8, + "parents": [ + 183784 + ], + "children": [ + 183774, + 183783 + ], + "area": 578426.4777079999, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 183774, + "strid": "ff91c3b6-26b1-4b2c-887d-a23ce6b6f493", + "image_id": 207672, + "image_name": "8576.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 278.59, + 2144.436, + 1309.296, + 257.31799999999976 + ], + "priority": 9, + "parents": [ + 183769 + ], + "children": [], + "area": 597418.42524, + "iscrowd": 0, + "segmentation": [], + "text": "Down regulation of La autoantigen, PSMA7, hVAP-A and NSSB genes resulted in\ninhibition of HCV replication by about 67.2%, 50.7%, 39% and 52% respectively.\nCombination therapies of siRNAs against La autoantigen with NSSB and La\n\nautoantigen with hVAP-A resulted in ~ 85% inhibition in HCV replication." + }, + { + "id": 183783, + "strid": "8c5ec583-ccf2-472f-abf0-3694302e2696", + "image_id": 207672, + "image_name": "8576.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 289.64, + 2473.057, + 1287.0900000000001, + 806.0100000000002 + ], + "priority": 10, + "parents": [ + 183769 + ], + "children": [], + "area": 716296.2294799999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 183770, + "strid": "9d7f81b2-d6b3-4464-97da-03b1b05006f3", + "image_id": 207672, + "image_name": "8576.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 280.073, + 3378.502, + 370.519, + 43.61700000000019 + ], + "priority": 11, + "parents": [ + 183784 + ], + "children": [ + 183775 + ], + "area": 946227.190646, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 183775, + "strid": "81967255-7ac5-44a0-8990-2750a4b658d4", + "image_id": 207672, + "image_name": "8576.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 277.514, + 3461.167, + 1311.138, + 395.6970000000001 + ], + "priority": 12, + "parents": [ + 183770 + ], + "children": [], + "area": 960522.298838, + "iscrowd": 0, + "segmentation": [], + "text": "Our findings indicate that in addition to HCV-specific siRNAs, siRNAs targeted to\nhost cellular genes have showed promising down regulation in HCV replication.\nWe also showed that simultaneous silencing of more than one target is more\neffective than silencing a single target to inhibit the viral replication. Therefore,\nmultiple combinations of siRNAs against both the virus and host genes are likely to\n\nbe a potent approach in the treatment of chronic hepatitis C." + }, + { + "id": 183776, + "strid": "c78016ad-151c-45db-8995-c48e17742e86", + "image_id": 207672, + "image_name": "8576.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 280.944, + 4002.843, + 1260.204, + 502.16600000000017 + ], + "priority": 13, + "parents": [ + 183784 + ], + "children": [], + "area": 1124574.723792, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 183777, + "strid": "b1355ffc-80f5-471e-b3fe-64114e627b20", + "image_id": 207672, + "image_name": "8576.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1688.394, + 887.373, + 1857.64, + 968.5039999999999 + ], + "priority": 14, + "parents": [ + 183784 + ], + "children": [], + "area": 1498235.248962, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 183778, + "strid": "a63d60bb-14de-4a1c-9882-4da19998070b", + "image_id": 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0, + "segmentation": [], + "text": "Estimating risk factors for maternal death, stillbirth, and low\nbirth weight amongst high-risk pregnant women: retrospective\ncohort, Port-au-Prince, Haiti" + }, + { + "id": 137831, + "strid": "3d7e2987-9f2c-43e2-bf0f-6eb2d7f002e1", + "image_id": 205845, + "image_name": "16461.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 130.928, + 576.039, + 3019.242, + 279.424 + ], + "priority": 2, + "parents": [ + 137850 + ], + "children": [], + "area": 75419.634192, + "iscrowd": 0, + "segmentation": [], + "text": "J Schuurmans?, E Borgundvaag}, P Finaldit, R Senat-Delva1, F Desauguste1, C Badjo1, M Lekkerkerker2, R Grandpierre3, G Lerebours?,\nC Ariti5, A Lenglet2\n\n1Médecins Sans Frontiéres (MSF), Port-au-Prince, Haiti; 2MSF, Amsterdam, The Netherlands; 3Ministére de la Santé Publique et de la Population, Port-au-Prince, Haiti; 4National Bioethics\nCommittee, Port-au-Prince, Haiti; 5SCentre for Trials Research, Cardiff, UK" + }, + 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Multivariate risk factors for maternal death, stillbirth and low birthweight" + }, + { + "id": 137849, + "strid": "04b4f63e-f051-4ed2-8b36-b707a3f18c14", + "image_id": 205845, + "image_name": "16461.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 138.968, + 3833.789, + 652.52, + 28.347999999999956 + ], + "priority": 16, + "parents": [ + 137835 + ], + "children": [], + "area": 532773.989752, + "iscrowd": 0, + "segmentation": [], + "text": "* Not maintained in the final multivariate model" + }, + { + "id": 137836, + "strid": "5018f886-a1c6-40aa-88a8-5b9184eee20f", + "image_id": 205845, + "image_name": "16461.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 140.744, + 3955.255, + 277.403, + 48.972999999999956 + ], + "priority": 17, + "parents": [ + 137850 + ], + "children": [ + 137845 + ], + "area": 556678.40972, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion" + }, + { + "id": 137845, + "strid": "8835596c-5ce4-4ea4-bfe2-3bb61c29d2f8", + "image_id": 205845, + "image_name": "16461.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 138.06, + 4090.97, + 2106.099, + 352.81100000000015 + ], + "priority": 18, + "parents": [ + 137836 + ], + "children": [], + "area": 564799.3182, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 137837, + "strid": "61a04eda-aba2-43fc-a1ef-e459de849e57", + "image_id": 205845, + "image_name": "16461.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2286.996, + 3845.305, + 364.837, + 43.19300000000021 + ], + "priority": 19, + "parents": [ + 137850 + ], + "children": [ + 137846 + ], + "area": 8794197.15378, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements" + }, + { + "id": 137846, + "strid": "b81a7061-4c8a-4ed2-af42-125d20cc5c3a", + "image_id": 205845, + "image_name": "16461.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2285.142, + 3956.293, + 917.4659999999999, + 291.55499999999984 + ], + "priority": 20, + "parents": [ + 137837 + ], + "children": [], + "area": 9040691.298605999, + "iscrowd": 0, + "segmentation": [], + "text": "We thank Médecins Sans Frontiéres, the ‘Ministére de\nla Santé Publique et de la Population’ (MSPP) and the\nNational Bioethics Committee for their support of this\nresearch. We also thank the CRUO hospital staff\ninvolved in data collection for their dedication and\nhard work." + }, + { + "id": 24097, + "strid": "e8a38e04-e466-4167-be56-0db512d01588", + "image_id": 201467, + "image_name": "117167.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 29.58, + 24.79, + 30.410000000000004, + 255.42 + ], + "priority": -1, + "parents": [], + "children": [ + 24095, + 24085, + 24090, + 24096, + 24086 + ], + "area": 733.2882, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 24085, + "strid": "9f7c471e-4de5-4ec7-9cf8-cd47dc213878", + "image_id": 201467, + "image_name": "117167.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 96.559, + 87.464, + 4329.242, + 211.95599999999996 + ], + "priority": 1, + "parents": [ + 24097 + ], + "children": [], + "area": 8445.436376, + "iscrowd": 0, + "segmentation": [], + "text": "Grey Matter Change in the Year Following the First Episode of.Mania: Association with Clinical Outcome\nProspective data from the Systematic Treatment Optimization Program for EarlyMania (STOP-EM)" + }, + { + "id": 24086, + "strid": "92b42ab1-4eca-4994-9bc8-d8fa36e970b5", + "image_id": 201467, + "image_name": "117167.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 533.878, + 318.985, + 3450.312, + 186.503 + ], + "priority": 2, + "parents": [ + 24097 + ], + "children": [], + "area": 170299.07383, + "iscrowd": 0, + "segmentation": [], + "text": "Jan=Marie Kozicky, David J. Bond, Marjorie Gonzalez, lvanJ. Torres, Raymond W. Lam,4akshmi N. Yatham\nDepartmentoft Psychiatry, University of British Columbia; Vancouver, Canada" + }, + { + "id": 24095, + "strid": "c60a2e80-e82a-43ff-9a09-ae5bacdcf2a0", + "image_id": 201467, + "image_name": "117167.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 169.094, + 673.125, + 326.204, + 76.99199999999996 + ], + "priority": 3, + "parents": [ + 24097 + ], + "children": [ + 24094 + ], + "area": 113821.39875, + "iscrowd": 0, + "segmentation": [], + "text": "Background" + }, + { + "id": 24094, + "strid": "e1e96027-1c3f-492a-9743-4b9408dd87d1", + "image_id": 201467, + "image_name": "117167.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 158.963, + 758.221, + 2018.008, + 332.2819999999999 + ], + "priority": 4, + "parents": [ + 24095 + ], + "children": [], + "area": 120529.084823, + "iscrowd": 0, + "segmentation": [], + "text": "Neurodegeneration has been hypothesized to occur alongside illness progression in\nBipolar | Disorder (BDI). While prior studies suggest that grey matter loss may be\naccelerated in patients with BDI compared to healthy subjects, this is the first\ninvestigation to specifically compare the extent of these changes between patients\nwho experience an affective recurrence over follow-up to those who remain well." + }, + { + "id": 24096, + "strid": "8e26c9d1-593d-4d2f-80f5-d1a3c43f3c1f", + "image_id": 201467, + "image_name": "117167.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 167.068, + 1201.94, + 245.16, + 56.730999999999995 + ], + "priority": 5, + "parents": [ + 24097 + ], + "children": [ + 24092, + 24093, + 24091, + 24087, + 24088 + ], + "area": 200805.71192000003, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 24093, + "strid": "71efde32-b694-4eb6-ab48-ee92532c8f06", + "image_id": 201467, + "image_name": "117167.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 160.989, + 1278.932, + 2018.0079999999998, + 415.35300000000007 + ], + "priority": 6, + "parents": [ + 24096 + ], + "children": [], + "area": 205893.983748, + "iscrowd": 0, + "segmentation": [], + "text": "41 patients with BDi who recently (<3 months) recovered from their first manic\nepisode and 23 healthy subjects (HS) underwent aT1- weighted 3T MRI scan at\nenrollment and again approximately 1 year later. Using voxel based morphometry\nwe compared whole brain grey matter volume between patients who remained well\n(BD,, 4; N=19) during this time period vs. experienced an affective recurrence\n\n(BD ;n=21; including depression (12), hypo/mania (6); or both (3)).\n\nrecurrl" + }, + { + "id": 24092, + "strid": "a708ac6b-9199-42c1-a889-595ca98fe8a4", + "image_id": 201467, + "image_name": "117167.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 171.12, + 1793.564, + 1955.1980000000003, + 735.479 + ], + "priority": 7, + "parents": [ + 24096 + ], + "children": [], + "area": 306914.67168, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 24091, + "strid": "fa67bbbc-4bb0-46cf-b718-d691923e96b0", + "image_id": 201467, + "image_name": "117167.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 163.016, + 2628.323, + 2026.112, + 786.1309999999999 + ], + "priority": 8, + "parents": [ + 24096 + ], + "children": [], + "area": 428458.70216799993, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 24087, + "strid": "a1481d82-2046-4a7b-826c-e628a746e050", + "image_id": 201467, + "image_name": "117167.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2330.126, + 656.838, + 2028.161, + 1084.132 + ], + "priority": 9, + "parents": [ + 24096 + ], + "children": [], + "area": 1530515.301588, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 24088, + "strid": "a6b26c36-ee35-466d-881f-fbbc6f44d8d8", + "image_id": 201467, + "image_name": "117167.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2330.126, + 1817.693, + 2024.8249999999998, + 1164.191 + ], + "priority": 10, + "parents": [ + 24096 + ], + "children": [], + "area": 4235453.719318001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 24090, + "strid": "6d19b774-49e6-44e2-9a0a-a3ed6e87459c", + "image_id": 201467, + "image_name": "117167.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2341.767, + 3059.56, + 301.9229999999998, + 59.22699999999986 + ], + "priority": 11, + "parents": [ + 24097 + ], + "children": [ + 24089 + ], + "area": 7164776.642519999, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion" + }, + { + "id": 24089, + "strid": "f1936819-0a18-4f44-b572-9dcff3dce544", + "image_id": 201467, + "image_name": "117167.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2340.746, + 3135.467, + 1975.6050000000005, + 267.2040000000002 + ], + "priority": 12, + "parents": [ + 24090 + ], + "children": [], + "area": 7339331.838382, + "iscrowd": 0, + "segmentation": [], + "text": "BDI is a dynamic illness whereby episode recurrence and remission are\naccompanied by opposing changes in grey matter volume. These differences are\nfound early in the course of illness, and maintained even after accounting for other\n\nclinical or treatment factors." + }, + { + "id": 118631, + "strid": "c33077cb-b3b2-4cf8-8057-a10f1c5678ff", + "image_id": 205116, + "image_name": "14238.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 14.69, + 15.98, + 20.740000000000002, + 52.78999999999999 + ], + "priority": -1, + "parents": [], + "children": [ + 118622, + 118606, + 118612, + 118616, + 118609, + 118625, + 118605, + 118619, + 118607, + 118628 + ], + "area": 234.7462, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 118605, + "strid": "082828be-4d8c-496e-ade6-b02002c034de", + "image_id": 205116, + "image_name": "14238.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 47.439, + 11.976, + 642.885, + 79.277 + ], + "priority": 1, + "parents": [ + 118631 + ], + "children": [], + "area": 568.1294640000001, + "iscrowd": 0, + "segmentation": [], + "text": "Laboratory Learning\nSUS aaa Stl se cit ea heal ma Oh ea iN" + }, + { + "id": 118606, + "strid": "63adcc10-a62b-4832-91c8-5885bf798f11", + "image_id": 205116, + "image_name": "14238.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 49.653, + 94.918, + 641.184, + 20.778999999999996 + ], + "priority": 2, + "parents": [ + 118631 + ], + "children": [], + "area": 4712.963454000001, + "iscrowd": 0, + "segmentation": [], + "text": "lanis G. 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Participants are provided\nwith genetic variants and make predictions of resulting phenotypes. These\npredictions are objectively assessed against experimental characterizations." + }, + { + "id": 144176, + "strid": "1bce080a-444e-4079-b1ef-755e05570def", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 71.101, + 692.497, + 689.481, + 472.7789999999999 + ], + "priority": 5, + "parents": [ + 144158 + ], + "children": [], + "area": 49237.22919699999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 144177, + "strid": "00d81785-d1fb-48d1-b72f-be58780c9a9e", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 75.513, + 1177.447, + 648.392, + 109.37699999999995 + ], + "priority": 6, + "parents": [ + 144158 + ], + "children": [], + "area": 88912.555311, + "iscrowd": 0, + "segmentation": [], + "text": "https://genomeinterpretation.org/vipdb\n\nEach name is scaled according to the logarithm of the\nnumber of citations. Colors are randomly assigned." + }, + { + "id": 144178, + "strid": "df393211-bd6c-44e6-aa78-c809347b3656", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 794.269, + 687.579, + 673.7949999999998, + 292.528 + ], + "priority": 7, + "parents": [ + 144158 + ], + "children": [], + "area": 546122.684751, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 144199, + "strid": "b180763a-1930-43f3-9b88-10ba118b509b", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 790.906, + 997.823, + 686.0700000000002, + 294.7710000000001 + ], + "priority": 8, + "parents": [ + 144158 + ], + "children": [], + "area": 789184.1976379999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 144159, + "strid": "4324cf6d-9caf-4ec3-91b3-96a209ecadea", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 257.253, + 1356.488, + 1030.028, + 47.87300000000005 + ], + "priority": 9, + "parents": [ + 144203 + ], + "children": [ + 144179 + ], + "area": 348960.607464, + "iscrowd": 0, + "segmentation": [], + "text": "Key themes emergent from CAGI experiments" + }, + { + "id": 144179, + "strid": "a54f2b5c-5ee3-4635-ad26-037fffe822da", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 139.377, + 1433.838, + 1261.886, + 415.8410000000001 + ], + "priority": 10, + "parents": [ + 144159 + ], + "children": [], + "area": 199844.038926, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 144160, + "strid": "68b5bc6b-099a-49cf-846f-7b1e5d856bff", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 103.668, + 1900.693, + 1350.096, + 46.28500000000008 + ], + "priority": 11, + "parents": [ + 144203 + ], + "children": [ + 144165, + 144169, + 144163, + 144167, + 144200, + 144168, + 144170, + 144164 + ], + "area": 197041.04192400002, + "iscrowd": 0, + "segmentation": [], + "text": "CAGI publications report advances in genome interpretation" + }, + { + "id": 144167, + "strid": "af03226e-cb9f-4b72-bb9d-4038f92ddfb9", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 55.087, + 1990.811, + 487.1070000000001, + 612.2279999999998 + ], + "priority": 12, + "parents": [ + 144160 + ], + "children": [], + "area": 109667.805557, + "iscrowd": 0, + "segmentation": [], + "text": "Human Mutation v38(9)\nCAGI Special Issue\n23 papers\nFuture directions for high-throughput\nsplicing assays in precision medicine\n\nCrohn disease risk prediction - Best\npractices and pitfalls with exome data\n\nMatching phenotypes to whole\ngenomes: Lessons learned from four\niterations of the personal genome\ncommunity challenges\n\nMissense variant pathogenicity\npredictors generalize well across a\nrange of function-specific challenges" + }, + { + "id": 144168, + "strid": "f20e329a-11b8-457a-9974-9c19eafed1b7", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 61.877, + 2643.972, + 509.59599999999995, + 345.3359999999998 + ], + "priority": 13, + "parents": [ + 144160 + ], + "children": [], + "area": 163601.05544400003, + "iscrowd": 0, + "segmentation": [], + "text": "Hoskins RA et al., Carraro M et al.\nZhang J et al., Capriotti E et al.\nKatsonis P et al., Niroula A et al.\nPejaver V et al., Yin Y et al., Xu Q etal.\nTang Q et al., Tang Q et al., Cai B et al.\nChandonia JM et al., Pal LR et al.\nDaneshiou et al., Giollo M et al.\n\nKundu K et al., Sundaram L et al.\n\nPal LR et al., Wang MH et al., Beer MA\nKreimer A et al., Zeng H et al." + }, + { + "id": 144163, + "strid": "2ce97bee-c6cc-4b3d-86d7-5ba5f6c6ce8d", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 548.156, + 1958.48, + 415.63699999999994, + 174.39300000000003 + ], + "priority": 14, + "parents": [ + 144160 + ], + "children": [], + "area": 1073552.5628799999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 144164, + "strid": "e9faabf8-5cd0-4bf3-9ee2-52feee3f726e", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 619.658, + 2143.791, + 302.28200000000004, + 172.19500000000016 + ], + "priority": 15, + "parents": [ + 144160 + ], + "children": [], + "area": 1328417.2434780002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 144200, + "strid": "b3189863-e374-4b81-b224-cab4539f5340", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 577.083, + 2314.866, + 414.433, + 171.5079999999998 + ], + "priority": 16, + "parents": [ + 144160 + ], + "children": [], + "area": 1335869.8158779999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 144165, + "strid": "cb0886e0-dd5c-4ac6-9275-f4d06eafd105", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 618.777, + 2497.466, + 341.962, + 313.12699999999995 + ], + "priority": 17, + "parents": [ + 144160 + ], + "children": [], + "area": 1545374.519082, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 144169, + "strid": "d15b4ac7-6ae2-4f16-8015-9ad499515001", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 996.57, + 1989.032, + 494.957, + 836.8990000000001 + ], + "priority": 18, + "parents": [ + 144160 + ], + "children": [], + "area": 1982209.62024, + "iscrowd": 0, + "segmentation": [], + "text": "Human Mutation v40(9)\nCAGI Special Issue\n36 papers\nCAGI SickKids challenges:\nassessment of phenotype and variant\npredictions derived from clinical and\ngenomic data of children with\nundiagnosed diseases\n\nAre machine learning based methods\nSuited to address complex biological\nproblems? Lessons from CAGI-5\nchallenges\n\nGotea V et al., Savojardo C et al.\nChen J, Cheng J et al., Chen K et al.\nPetrosino M et al., Wang R et al.\nNaito T, Shigaki D et al., Wang Y et al.\nGarg A and Pal D., Padilla N et al.\nKreimer A et al., Parsons MT et al.\nMcInnes G et al., Carraro M et al.\nCao Y et al., Aspromonte MC et al.\nPejaver V et al., Savojardo C et al." + }, + { + "id": 144170, + "strid": "1084fd12-5356-460b-a8ca-4b7fbad24131", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 680.924, + 2829.209, + 811.896, + 172.54799999999977 + ], + "priority": 19, + "parents": [ + 144160 + ], + "children": [], + "area": 1926476.3091159998, + "iscrowd": 0, + "segmentation": [], + "text": "WILEY Blackwell Adhikari AN, Dong S and Boyle AP\n\nHu Z et al., Zhang J et al., Voskanian A et al., Strokach A et al.\nMonzon AM et al., Miller M et al., Cline MS et al., Miller M et al.\nMount SM et al., Kasak L et al., Andreoletti G et al.\n\nKatsonis P & Lichtarge O, Kasak L et al., Clark WT et al." + }, + { + "id": 144180, + "strid": "7be4ba4d-e6f7-4ba0-bfbd-2655c5e2a615", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2034.938, + 402.818, + 980.3289999999997, + 45.95400000000001 + ], + "priority": 20, + "parents": [ + 144203 + ], + "children": [ + 144187, + 144182, + 144184, + 144186, + 144185, + 144193, + 144188, + 144195, + 144190, + 144194, + 144198, + 144181, + 144197, + 144189, + 144191, + 144183, + 144192 + ], + "area": 819709.655284, + "iscrowd": 0, + "segmentation": [], + "text": "A CAGI challenge exemplifies many themes" + }, + { + "id": 144181, + "strid": "be9150a9-d827-4fdb-8990-9c2803ed9330", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1552.378, + 469.595, + 889.2250000000001, + 454.7370000000001 + ], + "priority": 21, + "parents": [ + 144180 + ], + "children": [], + "area": 728988.94691, + "iscrowd": 0, + "segmentation": [], + "text": "Background: CAGI has had five editions and a total of\n50 challenges.\n\nNAGLU challenge: CAGI participants were challenged to\npredict the biochemical consequences of mutations in N-\nacetyl-glucosaminidase (NAGLU), a gene responsible for\nSanfilippo syndrome.\n\nDataset: 163 novel missense NAGLU mutations (ExAC).\nPredictions: 17 submissions from 10 groups.\nAssessment: Predictions were evaluated against a\n\ngold standard of enzyme activity as assessed in\n\nHEK291 cells" + }, + { + "id": 144189, + "strid": "676822d8-0e63-45fb-98eb-8cc310e5708c", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2713.396, + 464.356, + 275.17300000000023, + 329.005 + ], + "priority": 22, + "parents": [ + 144180 + ], + "children": [], + "area": 1259981.712976, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 144190, + "strid": "4c777e5a-80e8-4cea-85a1-1f185afbc123", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2541.022, + 795.324, + 654.8249999999998, + 109.13800000000003 + ], + "priority": 23, + "parents": [ + 144180 + ], + "children": [], + "area": 2020935.7811279998, + "iscrowd": 0, + "segmentation": [], + "text": "Black trace indicates measured (experimental)\nactivity (1.0 = wild type). Colored dots indicate\npredicted activity for the same variant." + }, + { + "id": 144182, + "strid": "401c1378-4bcc-4cec-be9a-a4f3a034067f", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1642.664, + 999.493, + 694.528, + 76.48300000000006 + ], + "priority": 24, + "parents": [ + 144180 + ], + "children": [], + "area": 1641831.169352, + "iscrowd": 0, + "segmentation": [], + "text": "Bespoke methods (in blue) enhance perfor-\nmance, and many exceed baseline (in brown)" + }, + { + "id": 144183, + "strid": "5e82f124-8b76-4cca-9e76-537f639dc6b9", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1639.574, + 1119.239, + 675.9870000000001, + 114.33799999999997 + ], + "priority": 25, + "parents": [ + 144180 + ], + "children": [], + "area": 1835075.1641860001, + "iscrowd": 0, + "segmentation": [], + "text": "Top missense methods are highly\nstatistically significant (p-value < 2.2e-16 for\nMoult, Lichtarge and Mooney-2)" + }, + { + "id": 144184, + "strid": "16ce5a32-6591-45d8-8e8a-f2eaf4ac558b", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1608.578, + 1257.839, + 724.5430000000001, + 463.4949999999999 + ], + "priority": 26, + "parents": [ + 144180 + ], + "children": [], + "area": 2023332.142942, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 144185, + "strid": "cec03772-96f7-4654-ba6f-1b03bc8903c6", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1641.221, + 1743.987, + 682.634, + 105.69399999999996 + ], + "priority": 27, + "parents": [ + 144180 + ], + "children": [], + "area": 2862268.0881270003, + "iscrowd": 0, + "segmentation": [], + "text": "(Also seen in other CAGI challenges such as CBS,\nSUMO, L-PYK, MRE11 and NSB1, BRCA1 and\nBRCA2, p16, RAD50, CHEK2 and SCN5A)" + }, + { + "id": 144191, + "strid": "ad3923b4-6894-4c61-893a-dfad8770cfcf", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2559.379, + 1062.74, + 658.1130000000003, + 150.60799999999995 + ], + "priority": 28, + "parents": [ + 144180 + ], + "children": [], + "area": 2719954.43846, + "iscrowd": 0, + "segmentation": [], + "text": "For an identifiable subset of variants, ac-\ncuracy is very high (left of red line, encircled\nvariants are all correctly predicted as deleteri-\n\nous. Predictions were made by Mooney-2)" + }, + { + "id": 144193, + "strid": "0e345775-b486-480b-a495-b967c1529bf1", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2507.037, + 1224.422, + 712.6480000000001, + 501.626 + ], + "priority": 29, + "parents": [ + 144180 + ], + "children": [], + "area": 3069671.257614, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 144192, + "strid": "e12392df-362a-4163-a91c-cda499e5496a", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2563.253, + 1743.764, + 681.7829999999999, + 105.22000000000003 + ], + "priority": 30, + "parents": [ + 144180 + ], + "children": [], + "area": 4469708.304292, + "iscrowd": 0, + "segmentation": [], + "text": "(Also seen in other CAGI challenges such as CBS,\nSUMO, L-PYK, MRE11 and NSB1, BRCA1 and\nBRCA2, p16, RAD50, CHEK2 and SCN5A)" + }, + { + "id": 144186, + "strid": "fd625c3c-3f70-404f-a3b1-76319fde0415", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1578.607, + 1945.249, + 652.2889999999998, + 113.90699999999993 + ], + "priority": 31, + "parents": [ + 144180 + ], + "children": [], + "area": 3070783.688143, + "iscrowd": 0, + "segmentation": [], + "text": "Missense impact prediction methods\ncorrelate better with each other than with\nexperiment" + }, + { + "id": 144187, + "strid": "9195c771-abef-4cc3-afa0-2d87c764c08e", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1581.747, + 2076.38, + 627.3260000000002, + 502.5329999999999 + ], + "priority": 32, + "parents": [ + 144180 + ], + "children": [], + "area": 3284307.8358600005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 144188, + "strid": "caa28c73-4fea-47ab-8779-943ce622dac7", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1576.425, + 2598.972, + 684.769, + 234.02599999999984 + ], + "priority": 33, + "parents": [ + 144180 + ], + "children": [], + "area": 4097084.4351000004, + "iscrowd": 0, + "segmentation": [], + "text": "Example of correlation of predictions made by\ntwo well-performing methods employing\ndifferent features.\n\n(Also seen in other CAGI challenges such as CBS,\n\nSUMO, L-PYK, MRE11 and NSB1, BRCA1 and\nBRCA2, p16, RAD50, CHEK2 and SCN5A)" + }, + { + "id": 144194, + "strid": "4498a640-ba23-4fa9-a842-09af40d9c993", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2272.237, + 1922.604, + 1063.1530000000002, + 838.5910000000001 + ], + "priority": 34, + "parents": [ + 144180 + ], + "children": [], + "area": 4368611.9451480005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 144195, + "strid": "cb3ba2d4-6937-4fe2-b96f-0019a9078926", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2392.445, + 2764.575, + 860.3650000000002, + 73.52500000000009 + ], + "priority": 35, + "parents": [ + 144180 + ], + "children": [], + "area": 6614093.635875, + "iscrowd": 0, + "segmentation": [], + "text": "Pairwise Pearson’s correlation coefficients between methods\nand experimental activity (fwt)." + }, + { + "id": 144197, + "strid": "5055f098-0821-4f5f-ab02-a14178e45a4c", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2212.788, + 2917.01, + 840.1880000000001, + 72.279 + ], + "priority": 36, + "parents": [ + 144180 + ], + "children": [], + "area": 6454724.72388, + "iscrowd": 0, + "segmentation": [], + "text": "Assessor: Wyatt T. Clark, BioMarin Pharmaceuticals.\nData provided by: Jon LeBowitz, BioMarin Pharmaceuticals" + }, + { + "id": 144198, + "strid": "4e70217e-f9da-491a-8f1e-15097d5cc8f1", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3085.244, + 2877.459, + 231.79800000000023, + 111.6239999999998 + ], + "priority": 37, + "parents": [ + 144180 + ], + "children": [], + "area": 8877663.114996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 144161, + "strid": "bcf8d0ad-9f4f-48f6-8f1f-e24beb2b1600", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 395.923, + 3050.95, + 1131.607, + 49.9079999999999 + ], + "priority": 38, + "parents": [ + 144203 + ], + "children": [ + 144174, + 144202, + 144173, + 144171, + 144166, + 144172, + 144201 + ], + "area": 1207941.27685, + "iscrowd": 0, + "segmentation": [], + "text": "Prediction challenges from the 5th edition of CAGI" + }, + { + "id": 144171, + "strid": "bb3d465d-ef92-4387-b34b-c885792f2f42", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 66.266, + 3103.647, + 729.856, + 950.6040000000003 + ], + "priority": 39, + "parents": [ + 144161 + ], + "children": [], + "area": 205666.27210200002, + "iscrowd": 0, + "segmentation": [], + "text": "Missense\n\nGAA. Predict effect of naturally occurring\nmissense mutations in acid alpha-glucosidase\non cellular enzymatic activity. Data provided by:\nJon LeBowitz, Biomarin Pharmaceuticals\nFrataxin. Predict impact of frataxin variants on\nthe protein’s thermodynamic stability. Data\nprovided by: Roberta Chiaraluce and Valerio\nConsalvi, Sapienza University, Roma, Italy\n\nPTMT and PTEN. Predict effect of mutations on\nprotein stability as assessed in a multiplexed\nprofiling assay in human cells. Data provided by:\nKenneth Matreyek, Lea Starita and Doug Fowler, UW\nCALM1. Predict effects of missense mutations in\nhuman CALM1 on competitive growth in a HT\nyeast complementation assay. Data provided by:\nFrederick \"Fritz\" Roth, University of Toronto, Canada\nPCM'1. Predict effects of single-amino-acid\nmutations on zebrafish development. Data\nprovided by: Nicholas Katsanis, Duke University\nAnnotate all missense. Predict the impact of all\nnonsynonymous variants in the genome. Data\nprovided by: Xiaoming Liu (dAbNSFP), University of\nTexas Health Science Center, Houston" + }, + { + "id": 144201, + "strid": "153840f7-75aa-4c65-8bcc-a07f23dec922", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 69.788, + 4060.246, + 742.547, + 310.65200000000004 + ], + "priority": 40, + "parents": [ + 144161 + ], + "children": [], + "area": 283356.447848, + "iscrowd": 0, + "segmentation": [], + "text": "Regulatory variants\nRegulation saturation. Identify non-coding |\nsequence effects assessed in a massively parallel\nreporter assay data from saturation mutagenesis\nof multiple promoter and enhancer elements. Data\nprovided by: Martin Kircher, Translational Genomics\nCenter, Berlin Institute of Health, Berlin, Germany &\nDepartment of Genome Sciences, UW" + }, + { + "id": 144166, + "strid": "f402dedb-dc6c-48f5-9070-fcd5196e5b59", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 790.024, + 3128.551, + 252.95899999999995, + 1142.149 + ], + "priority": 41, + "parents": [ + 144161 + ], + "children": [], + "area": 2471630.375224, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 144202, + "strid": "ea4c2ebf-85af-4a9e-b12f-fb605c5e075a", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1046.862, + 3112.12, + 739.6959999999999, + 351.84799999999996 + ], + "priority": 42, + "parents": [ + 144161 + ], + "children": [], + "area": 3257960.16744, + "iscrowd": 0, + "segmentation": [], + "text": "Splicing\n\nMaPSy. Predict effects of variants and deletions\non splicing efficiency and altered splice site usage\nrelative to the reference sequence.\n\nData provided by: Will Fairbrother, Brown University\nVex-seq. Predict impact of genetic variation on\nsplicing efficiency as assessed in high-throughput\nassay. Data provided by: Brenton R. Graveley,\n\nUConn Health, Farmington" + }, + { + "id": 144172, + "strid": "f8780d57-8aa6-455c-b404-401a7ef495d9", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1046.032, + 3471.389, + 752.53, + 305.7739999999999 + ], + "priority": 43, + "parents": [ + 144161 + ], + "children": [], + "area": 3631183.978448, + "iscrowd": 0, + "segmentation": [], + "text": "Complex disease exomes\n\nIntellectual disability panel. Predict patients’\nclinical descriptions and pathogenic variants from\ngene panel sequences. Data provided by: Emanuela\nLeonardi, Alessandra Murgia, University of Padua\nClotting disorders. Distinguish genomes of\ndiseased individuals from controls. Data by: Roxana\nDaneshjou and Russ Altman, Stanford University" + }, + { + "id": 144173, + "strid": "48d304de-16c5-4a06-80e6-cfcc01c14c63", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1048.313, + 3781.229, + 724.4569999999999, + 189.73000000000002 + ], + "priority": 44, + "parents": [ + 144161 + ], + "children": [], + "area": 3963911.516677, + "iscrowd": 0, + "segmentation": [], + "text": "Clinical genomes\n\nSickKids clinical genomes. Match patients’\ngenomes to their clinical descriptions and predict\ncausal pathogenic variants. Data provided by:\nStephen Meyn & colleagues, SickKids" + }, + { + "id": 144174, + "strid": "2c422bb4-9987-402c-afb9-caef3639c90f", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1047.056, + 3978.013, + 783.604, + 383.6210000000001 + ], + "priority": 45, + "parents": [ + 144161 + ], + "children": [], + "area": 4165202.379728, + "iscrowd": 0, + "segmentation": [], + "text": "Germline cancer variants\n\nCHEK2 variants. Predict probability of an individual\nwith a given mutation being in the case (breast\ncancer) or control (healthy). Data provided by: Elad Ziv\nand Susan Neuhausen, UCSF\n\nENIGMA. Predict probability that BRCA1 & BRCA2\nvariants evaluated by the ENIGMA consortium are\npathogenic. Data provided by: Amanda Spurdle, QIMR\nBerghofer Medical Research Institute, Brisbane, Australia\nand the ENIGMA consortium" + }, + { + "id": 144162, + "strid": "212586e8-8742-48c6-a9b0-74fd5d6a33f5", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2412.439, + 3050.531, + 443.6329999999998, + 50.69900000000007 + ], + "priority": 46, + "parents": [ + 144203 + ], + "children": [ + 144196 + ], + "area": 7359219.955108999, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements" + }, + { + "id": 144196, + "strid": "d0f3721d-3ff4-4548-b9e6-13df8bf372eb", + "image_id": 206101, + "image_name": "17420.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1879.019, + 3113.772, + 1478.001, + 1126.3339999999998 + ], + "priority": 47, + "parents": [ + 144162 + ], + "children": [], + "area": 5850836.749668, + "iscrowd": 0, + "segmentation": [], + "text": "Organizers: Stephen E. Brenner, John Moult, Daniel Barsky, Roger A. Hoskins, Susanna Repo, Gaia Andreoletti, Predrag Radivojac, Constantina Bakolitsa\nEthics Forum: Wylie Burke, Flavia Chen, Julie Harris-Wai, Kirsten Isgro, Barbara A. Koenig, Robert Nussbaum, Mark Yarborough, Stephanie Malia Fullerton\n\nAdvisory Board: Russ Altman, George Church, Tim Hubbard, Scott Kahn, Sean Mooney, Pauline Ng, Susanna Repo, John Shon, Rachel Karchin, Robert\nNussbaum, Michael Snyder, Serafim Batzoglou Scientific Council: Patricia Babbitt, Atul Butte, Garry Cutting, Laura Elnitski, Reece Hart, Ryan Hernandez,\nRachel Karchin, Robert Nussbaum, Michael Snyder, Shamil Sunyaev, Joris Veltman, Liping Wei, Yana Bromberg, George Church, Justin Cook, John Moult\n\nWebsite Development: Sadhna Rana, Navya Dabbiru, Stephen Yee, Maya Zuhl, Sri Jyothsna Yeleswarapu, Gaurav Pandey\n\nData Providers: Russ Altman, Adam P. Arkin, Madeleine P. Ball, Jason Bobe, Paolo Bonvini, Bethany Buckley, George Church, Garry R. Cutting, Emma D’\nAndrea, Lisa Elefanti, Aron W. Fenton, Andre Franke, Nina Gonzaludo, Joe W. Gray, Linnea Jannson, John P. Kane, Pui-Yan Kwok, Rick Lathrop, Jonathan H.\nLebowitz, Federica Lovisa, Angel C. Y. Mak, Mary J. Malloy, Richard McCombie, Chiara Menin, M. Stephen Meyn, John Moult, Robert Nussbaum, Mehdi Pirooznia,\nJames B. Potash, CLive R. Pullinger, Jasper Rine, Frederick Roth, Pardis Sabeti, Jeremy Sanford, Maria C. Scaini, Nicole Schmitt, Jay Shendure, Molly Sheridan,\nMichael Snyder, Tim Sterne-Weiler, Paul L. F. Tang, Sean Tavtigian, Ryan Tewhey, Silvio C. E. Tosatto, Jochen Weile, G. Karen Yu, Peter Zandi\n\nAssessors: Aashish Adhikari, Marco Carraro, John-Marc Chandonia, Rui Chen, Wyatt T. Clark, Roxana Denshiou, Roland Dunbrack, Iddo Friedberg, Gad Getz,\nNick Grishin, Rachel Karchin, Anat Kreimer, Stephen Meyn, Sean D. Mooney, Alexander A. Morgan, John Moult, Robert Nussbaum, Jeremy Sanford, David B.\nSearls, Artem Sokolov, Josh Stuart, Shamil Sunyaev, Sean Tavtigian, Silvio C. E. Tosatto, Qifang Xu, Nir Yosef\n\nPredictors: Allison Abad, Ogun Adebali, Ivan Adzhubey, Talal Amin, Johnathan R. Azaria, Giulia Babbi, Eraan Bachar, Benjamin Bachman, Minkyung\nBaek, Greet De Baets, Michael Beer, Violeta Beleva-Guthrie, Bonnie Berger, Brady Bernard, Rajendra Bhat, Rohit Bhattacharya, Samuele Bovo, Marcus\nBreese, Aharon S. Brodie, Yana Bromberg, Binghuang Cai, Colin Campbell, Chen Cao, Emidio Capriotti, Marco Carraro, Rita Casadio, Billy H. W. Chang,\nShann-Ching Chen, Yun-Ching Chen, Chien-Yuan Chen, Melissa Cline, Andrea Corredor, Carla Davis, Mark Diekhans, Rezarta |. Dogan, Christopher\nDouville, lan Driver, Roland Dunbrack, Joost van Durme, Andrea Eakin, Matthew Edwards, Gokcen Eraslan, Hai Fang, Carlo Ferrari, Anna Flynn, Lukas\nFolkman, Colby T. Ford, Adam Frankish, Zaneta Franklin, Yao Fu, Alessandra Gasparini, Tom Gaunt, David Gifford, Manuel Giollo, Nina Gonzaludo, Valer\nGotea, Julian Gough, Yuchun Guo, Jennifer Harrow, Marcia Hasenahuer, Lim Heo, Ramin Homayouni, Raghavendra Hosur, Cheng L. V. Huang, Peter\nHuwe, Sohyun Hwang, Tadashi Imanishi, Jules Jacobsen, Chan-Seok Jeong, Yuxiang Jiang, David T. Jones, Daniel Jordan, Beomchang Kang, Rachel\nKarchin, Panagiotis Katsonis, Sunduz Keles, Manolis Kellis, Nikki Kiga, Dongsup Kim, Eiru Kim, Jack F. Kirsch, Michael Kleyman, Andreas Kraemer,\nAnshul Kundaje, Kunal Kundu, Pui-Yan Kwok, Ernest Lam, Dae Lee, Gyu R. Lee, Insuk Lee, Pietro Di Lena, Emanuela Leonardi, Andy Li, Jun Li, Yue Li,\nBiao Li, Olivier Lichtarge, Chiao-Feng Lin, Rhonald C. Lua, Angel Mak, Pier L. Martelli, David Masica, Zev Medoff, Aziz M. Mezlini, Rahul Mohan, Alexan-\nder M. Monzon, Sean D. Mooney, Matthew Mort, John Moult, Steve Mount, Eliseos Mucaki, Jonathan Mudge, Nikola Mueller, Chris Mungall, Katsuhiko\nMurakami, Yoko Nagai, Noushin Niknafs, Abhishek Niroula, Conor M. L. Nodzak, Yanay Ofran, Ayodeji Olatubosun, Kymberleigh Pagel, Lipika R. Pal,\nTaeyong Park, Nathaniel Pearson, Vikas Pejaver, Jian Peng, Alexandra Piryatinska, Catherine Plotts, Predrag Radivojac, Aditya R. Rao, Aliz Rao, Graham\nRitchie, Peter Rogan, Frederic Rousseau, Jana M. Schwarz, Joost Schymkowitz, Chaok Seok, George Shackelford, Sohela Shah, Maxim Shatsky, Ron\nShigeta, Hashem A. Shihab, Jung E. Shim, Junha Shin, Sunyoung Shin, Ilya Shmulevich, Bradford R. Silver, Nasa Sinnott-Armstrong, Ben Smithers,\nYesim A. Son, Mario Stanke, Nathan Stitziel, Andrew Su, Laksshman Sundaram, Paul Tang, Nuttinee Teerakulkittipong, Natalie Thurlby, Janita Thusberg,\nKevin Tian, Collin Tokheim, Silvio C. E. Tosatto, Yemliha Tuncel, Tychele Turner, Ron S. Unger, Aneeta Uppal, Gurkan Ustunkar, Jouni Valiaho, Mauno\nVihinen, Mary Wahl, Michael Wainberg, Meng Wang, Maggie Wang, Yanran Wang, Xinyuan Wang, Li-San Wang, Liping Wei, Qiong Wei, Rene Welch,\nStephen Wilson, Chunlei Wu, Lijing Xu, Qifang Xu, Yuedong Yang, Christopher Yates, Yizhou Yin, Chen-Hsin Yu, Dejian Yuan, Jan Zaucha, Haoyang\nZeng, Maya Zuhl. The CAGI experiment is supported by NIH U41 HG007346, U24 HG007346, and the CAGI converence by NIH R13 HG006650." + }, + { + "id": 6232, + "strid": "45c58a7c-33f2-43ce-afc1-229f38b565f3", + "image_id": 200751, + "image_name": "10786.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 418.18, + 60.36, + 160.54000000000002, + 149.07999999999998 + ], + "priority": -1, + "parents": [], + "children": [ + 6216, + 6223, + 6218, + 6217, + 6219, + 6221, + 6222, + 6224, + 6220 + ], + "area": 25241.3448, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 6224, + "strid": "61abadb1-99fc-4c42-9617-f7c253cfc819", + "image_id": 200751, + "image_name": "10786.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 655.057, + 79.644, + 2296.08, + 258.989 + ], + "priority": 1, + "parents": [ + 6232 + ], + "children": [], + "area": 52171.359708, + "iscrowd": 0, + "segmentation": [], + "text": "Merging two grape genome assemblies iteratively\nimproves the quality" + }, + { + "id": 6223, + "strid": "4a4f5feb-1c80-4cb7-8a67-5a0b1a99d49b", + "image_id": 200751, + "image_name": "10786.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 511.416, + 349.515, + 2570.304, + 217.63800000000003 + ], + "priority": 2, + "parents": [ + 6232 + ], + "children": [], + "area": 178747.56324, + "iscrowd": 0, + "segmentation": [], + "text": "Zhixiu LuS, Sagar Patel\", Anne Fennell*, and Erliang Zeng® *\n§ Department of Computer Science and * Department of Biology, University of South Dakota, Vermillion, SD, USA\n* Department of Agronomy, Horticulture, and Plant Science, South Dakota State University, Brookings, SD, USA" + }, + { + "id": 6222, + "strid": "d17915de-3412-4129-8fb3-3065ef41777b", + "image_id": 200751, + "image_name": "10786.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 774.932, + 620.605, + 271.87300000000005, + 43.875999999999976 + ], + "priority": 3, + "parents": [ + 6232 + ], + "children": [ + 6211 + ], + "area": 480926.67386000004, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 6211, + "strid": "d2c156ed-bfaf-4fcd-8c41-7b70de3b5de0", + "image_id": 200751, + "image_name": "10786.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 63.406, + 670.517, + 1701.119, + 219.05399999999997 + ], + "priority": 4, + "parents": [ + 6222 + ], + "children": [], + "area": 42514.800902, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 6221, + "strid": "ef6c736e-ba66-46f4-9fac-2fe49e343f8a", + "image_id": 200751, + "image_name": "10786.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 491.62, + 979.916, + 851.1910000000001, + 57.0379999999999 + ], + "priority": 5, + "parents": [ + 6232 + ], + "children": [ + 6225 + ], + "area": 481746.30392000003, + "iscrowd": 0, + "segmentation": [], + "text": "Workflow for Vitis vinifera cv. Sultanina" + }, + { + "id": 6225, + "strid": "a9230ffd-d99b-4a52-bff7-906f40185c73", + "image_id": 200751, + "image_name": "10786.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 57.826, + 1057.509, + 1711.863, + 2088.164 + ], + "priority": 6, + "parents": [ + 6221 + ], + "children": [], + "area": 61151.515434, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 6219, + "strid": "2a3281a6-e34b-4e94-94ac-73fb36fc318f", + "image_id": 200751, + "image_name": "10786.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2593.165, + 622.302, + 201.23199999999997, + 49.754999999999995 + ], + "priority": 7, + "parents": [ + 6232 + ], + "children": [ + 6212 + ], + "area": 1613731.76583, + "iscrowd": 0, + "segmentation": [], + "text": "Objective" + }, + { + "id": 6212, + "strid": "50930324-f77c-4210-81ee-4d8c027b133f", + "image_id": 200751, + "image_name": "10786.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1843.463, + 678.411, + 1685.331, + 242.735 + ], + "priority": 8, + "parents": [ + 6219 + ], + "children": [], + "area": 1250625.577293, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 6220, + "strid": "aa290028-499d-4c08-9167-81e01c7a96c1", + "image_id": 200751, + "image_name": "10786.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2614.173, + 975.011, + 163.63900000000012, + 41.462999999999965 + ], + "priority": 9, + "parents": [ + 6232 + ], + "children": [ + 6231, + 6226, + 6230 + ], + "area": 2548847.430903, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 6230, + "strid": "b9f9fd7e-3dad-4d2e-b11b-0866910f28df", + "image_id": 200751, + "image_name": "10786.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1881.988, + 1036.674, + 1624.0509999999997, + 783.6990000000001 + ], + "priority": 10, + "parents": [ + 6220 + ], + "children": [ + 6229 + ], + "area": 1951008.027912, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 6229, + "strid": "3f9124bb-787c-423c-90b5-2021d03ea571", + "image_id": 200751, + "image_name": "10786.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1897.725, + 1829.815, + 1603.5930000000003, + 113.30600000000004 + ], + "priority": 11, + "parents": [ + 6230 + ], + "children": [], + "area": 3472485.670875, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1. Comparison of published ALLPATHS-LG assembly with our PLATANUS assembly and merged assemblies by Assemblathon script. “Improved\nALLPATHS-LG assembly” was obtained using ALLPATHS-LG assembly as initial assembly, and then merged with PLATANUS assembly by MetaAssembler\niteratively till convergence. “Improved PLATANUS assembly” was obtained using PLATANUS assembly as initial assembly, and then merged with\nALLPATHS-LG assembly by MetaAssembler iteratively till convergence." + }, + { + "id": 6231, + "strid": "ecba9269-7d9b-4c2e-8932-849506496488", + "image_id": 200751, + "image_name": "10786.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1888.283, + 1998.2, + 1609.8870000000002, + 682.9819999999997 + ], + "priority": 12, + "parents": [ + 6220 + ], + "children": [ + 6227 + ], + "area": 3773167.0905999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 6227, + "strid": "6a18f7f7-a22c-40e4-916c-cd0cefa18e1a", + "image_id": 200751, + "image_name": "10786.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1886.709, + 2692.198, + 1608.314, + 58.22699999999986 + ], + "priority": 13, + "parents": [ + 6231 + ], + "children": [], + "area": 5079394.196382, + "iscrowd": 0, + "segmentation": [], + "text": "Table 2. Mapping results of mRNA, EST with > 90% identity and > 70% coverage. BAC with > 90% identity and > 90% coverage and reference genome with\n> 95% identity with published ALLPATHS-LG assembly, our PLATANUS assembly, and our merged PLATANUS assembly." + }, + { + "id": 6226, + "strid": "9adad2b3-a123-4685-8f93-b416c681dde9", + "image_id": 200751, + "image_name": "10786.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1886.709, + 2794.488, + 1598.872, + 860.81 + ], + "priority": 14, + "parents": [ + 6220 + ], + "children": [ + 6228 + ], + "area": 5272385.659992, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 6228, + "strid": "2b17abdb-16ff-4fec-904c-46c355cfe5a2", + "image_id": 200751, + "image_name": "10786.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1896.151, + 3664.74, + 1598.872, + 58.22699999999986 + ], + "priority": 15, + "parents": [ + 6226 + ], + "children": [], + "area": 6948900.41574, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. Assembly QUAST cumulative length plot. Scaffolds lengths of published ALLPATHS-LG assembly, PLATANUS assembly, and their improved merged\nones are shown. On the x-axis, scaffolds are ordered from the largest to smallest. The y-axis gives the size of the x largest scaffolds in the assembly." + }, + { + "id": 6217, + "strid": "59b7bad0-73e6-45d3-842a-d1a325ad25d5", + "image_id": 200751, + "image_name": "10786.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2535.904, + 3788.232, + 246.82900000000018, + 45.48999999999978 + ], + "priority": 16, + "parents": [ + 6232 + ], + "children": [ + 6214 + ], + "area": 9606592.681728, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion" + }, + { + "id": 6214, + "strid": "741f280a-5309-457e-8866-aef6729bfbdf", + "image_id": 200751, + "image_name": "10786.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1838.295, + 3886.028, + 1682.136, + 469.87000000000035 + ], + "priority": 17, + "parents": [ + 6217 + ], + "children": [], + "area": 7143665.84226, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 6216, + "strid": "c259ee9a-e563-43b5-a0e6-03b1f326b888", + "image_id": 200751, + "image_name": "10786.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 695.992, + 4146.348, + 447.01800000000003, + 50.96299999999974 + ], + "priority": 18, + "parents": [ + 6232 + ], + "children": [ + 6215 + ], + "area": 2885825.037216, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements" + }, + { + "id": 6215, + "strid": "a0031fcc-d84d-4a88-b1b7-dcfd1febfd57", + "image_id": 200751, + "image_name": "10786.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 75.609, + 4202.574, + 1678.109, + 157.6869999999999 + ], + "priority": 19, + "parents": [ + 6216 + ], + "children": [], + "area": 317752.41756599996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 6218, + "strid": "07a725e9-3f4d-4209-8321-cd813999cd6c", + "image_id": 200751, + "image_name": "10786.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 773.685, + 3242.702, + 251.7539999999999, + 50.35100000000011 + ], + "priority": 20, + "parents": [ + 6232 + ], + "children": [ + 6213 + ], + "area": 2508829.89687, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 6213, + "strid": "5ca9e8e2-dfaa-4b90-bb0b-d0243d3447c4", + "image_id": 200751, + "image_name": "10786.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 73.931, + 3329.232, + 1703.28, + 662.5169999999998 + ], + "priority": 21, + "parents": [ + 6218 + ], + "children": [], + "area": 246133.450992, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 82037, + "strid": "c62dd416-a91a-44c7-af07-9aa764d86cdb", + "image_id": 203690, + "image_name": "120748.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 63.12, + 386.17, + 377.05, + 115.55000000000001 + ], + "priority": -1, + "parents": [], + "children": [ + 82017, + 82018, + 82019, + 82016, + 82014, + 82015, + 82012, + 82028, + 82029, + 82013 + ], + "area": 24375.0504, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 82012, + "strid": "7e9ebd44-95de-46e1-aa16-c429eac841ad", + "image_id": 203690, + "image_name": "120748.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 558.359, + 105.128, + 2382.712, + 423.463 + ], + "priority": 1, + "parents": [ + 82037 + ], + "children": [], + "area": 58699.16495200001, + "iscrowd": 0, + "segmentation": [], + "text": "Training perceptual skills in soccer:\nEffects of alongitudinal protocol on\npredictive abilities of skilled goalkeepers" + }, + { + "id": 82013, + "strid": "c6a64af4-2aa5-4407-91fd-b37b0bb5ba38", + "image_id": 203690, + "image_name": "120748.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 242.862, + 607.114, + 3050.955, + 236.961 + ], + "priority": 2, + "parents": [ + 82037 + ], + "children": [], + "area": 147444.92026800002, + "iscrowd": 0, + "segmentation": [], + "text": "Mauro Murgia'?, Fabrizio Sors!;Alessandro Franco Muroni', Stefania Pertoldi', Marco Guicciardi*, Tiziano Agostini’\n\n \n\n‘Mind In Sport Lab, Department of Life Sciences, University of Trieste, Italy\n*Department of Pedagogy, Psychology; Philosophy, University of Cagliari, Italy\n\n \n\niuromurgianet @tiscali.it" + }, + { + "id": 82014, + "strid": "6a45505f-5f5c-42e1-8ee8-4cf334936b76", + "image_id": 203690, + "image_name": "120748.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1593.416, + 937.617, + 354.3979999999999, + 52.152000000000044 + ], + "priority": 3, + "parents": [ + 82037 + ], + "children": [ + 82020 + ], + "area": 1494013.929672, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 82020, + "strid": "50b6229e-f2c9-4c0f-b37f-105643b26447", + "image_id": 203690, + "image_name": "120748.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 62.925, + 998.463, + 3419.106, + 271.991 + ], + "priority": 4, + "parents": [ + 82014 + ], + "children": [], + "area": 62828.284275, + "iscrowd": 0, + "segmentation": [], + "text": "Good perceptual skills represent afundamental requirement for goalkeepers, since they-have to quickly capture environmental information and react as rapidly as possible in order to maximize their\nchances to save the goal. Therefore, goalkeepers must be trained in “reading” the-perceptual scene in order to anticipate their own’ movement (Diaz et al., 2012; Ryu et al., 2013; Savelsbergh et al.,\n2010). The aim of the present:study is to test whether skilled goalkeepers can,/benefit from a perceptual training. To achieve this‘aim, an innovative “take-away” protocol was developed, consisting in\nan interactive home-trainingsto be carried out on one’s own personal_computer. This allows participants to schedule..practice sessions on their own, a condition which can promote greater\nperformance improvements with respect to a fixed scheduling (Wu and Magill 2011)." + }, + { + "id": 82015, + "strid": "d83d9b8e-1732-42b8-a19e-3d0e63157889", + "image_id": 203690, + "image_name": "120748.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 704.457, + 1340.611, + 350.842, + 65.19000000000005 + ], + "priority": 5, + "parents": [ + 82037 + ], + "children": [ + 82021 + ], + "area": 944402.803227, + "iscrowd": 0, + "segmentation": [], + "text": "Participants" + }, + { + "id": 82021, + "strid": "7aebbb1e-b90d-4c97-a586-119a55aea288", + "image_id": 203690, + "image_name": "120748.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 47.911, + 1410.126, + 1679.958, + 263.5229999999999 + ], + "priority": 6, + "parents": [ + 82015 + ], + "children": [], + "area": 67560.546786, + "iscrowd": 0, + "segmentation": [], + "text": "38 soccer goalkeepers (mean age = 15,97 years; SD = 4,91); playing in the academies of\nprofessionakand semi-professional Italian teams, voluntarily participated in this experiment. They\nhave anaverage experience as goalkeepers of 9,28 years (SD = 2,59). They compete at national\nand“international level, and train between four and _six-times a week, for an average amount of\n7,99 hours (SD = 2,01) per week." + }, + { + "id": 82016, + "strid": "c3b6bfb8-dabb-4bcf-8651-c4366d6b8176", + "image_id": 203690, + "image_name": "120748.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 647.399, + 1723.017, + 515.0869999999999, + 65.99299999999994 + ], + "priority": 7, + "parents": [ + 82037 + ], + "children": [ + 82030 + ], + "area": 1115479.482783, + "iscrowd": 0, + "segmentation": [], + "text": "Recording setting" + }, + { + "id": 82030, + "strid": "cf3b0f47-896d-4ee1-9dee-45c54c3d30a9", + "image_id": 203690, + "image_name": "120748.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 82.38, + 1812.024, + 1640.9319999999998, + 703.2559999999999 + ], + "priority": 8, + "parents": [ + 82016 + ], + "children": [], + "area": 149274.53712, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 82028, + "strid": "4568b6b3-63b1-4ca4-bcb2-558a23551a13", + "image_id": 203690, + "image_name": "120748.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2458.914, + 1317.778, + 346.797, + 65.57999999999993 + ], + "priority": 9, + "parents": [ + 82037 + ], + "children": [ + 82022, + 82036, + 82033, + 82034, + 82032, + 82035 + ], + "area": 3240302.7730920003, + "iscrowd": 0, + "segmentation": [], + "text": "The training" + }, + { + "id": 82032, + "strid": "508a3eb6-6fa5-4d4a-b65e-6fef61f33687", + "image_id": 203690, + "image_name": "120748.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2390.081, + 1387.504, + 512.6320000000001, + 286.797 + ], + "priority": 10, + "parents": [ + 82028 + ], + "children": [], + "area": 3316246.947824, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 82033, + "strid": "3785c0a1-b7a1-4f2d-bcf8-110aa6b91aae", + "image_id": 203690, + "image_name": "120748.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1787.006, + 1758.154, + 511.67499999999995, + 288.895 + ], + "priority": 11, + "parents": [ + 82028 + ], + "children": [], + "area": 3141831.7469240003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 82034, + "strid": "d83adb21-e79e-4176-82d4-7419d1e15415", + "image_id": 203690, + "image_name": "120748.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2392.479, + 1759.846, + 509.971, + 288.087 + ], + "priority": 12, + "parents": [ + 82028 + ], + "children": [], + "area": 4210394.598234, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 82035, + "strid": "9d2457eb-c22a-4e4e-ab38-14c1c16cda6e", + "image_id": 203690, + "image_name": "120748.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2983.472, + 1763.041, + 511.8299999999999, + 288.6870000000001 + ], + "priority": 13, + "parents": [ + 82028 + ], + "children": [], + "area": 5259983.458352, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 82022, + "strid": "ea7ee7b5-0384-477a-8877-1a9def89f2d0", + "image_id": 203690, + "image_name": "120748.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1784.599, + 2072.593, + 1176.702, + 325.74299999999994 + ], + "priority": 14, + "parents": [ + 82028 + ], + "children": [], + "area": 3698747.3952069995, + "iscrowd": 0, + "segmentation": [], + "text": "On the black screen which occluded training penalties there were\nfour white sectors. with a question mark: Subjects made their\npredictions by~clicking one of them. In case of wrong prediction;\nthey received.a negative feedback and were invited to try again: In\ncase of correct prediction, they received an un-occluded: feedback\nfrom both goalkeeper perspective and an external one." + }, + { + "id": 82036, + "strid": "0094265b-618d-432b-8600-ad935da3b816", + "image_id": 203690, + "image_name": "120748.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2983.694, + 2140.643, + 511.46900000000005, + 286.8589999999999 + ], + "priority": 15, + "parents": [ + 82028 + ], + "children": [], + "area": 6387023.675242, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 82017, + "strid": "cfc8a5cd-c970-4bd6-92a4-95910214ac0c", + "image_id": 203690, + "image_name": "120748.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 730.335, + 2552.421, + 302.4200000000001, + 53.29500000000007 + ], + "priority": 16, + "parents": [ + 82037 + ], + "children": [ + 82023 + ], + "area": 1864122.3910349999, + "iscrowd": 0, + "segmentation": [], + "text": "Procedure" + }, + { + "id": 82023, + "strid": "d75e1936-0555-4d94-8a45-3d422086a8ef", + "image_id": 203690, + "image_name": "120748.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 46.081, + 2621.598, + 1679.958, + 880.239 + ], + "priority": 17, + "parents": [ + 82017 + ], + "children": [], + "area": 120805.857438, + "iscrowd": 0, + "segmentation": [], + "text": "Pre- and post-test consisted in the presentation of 96 penalties recorded from goalkéeper\nperspective, temporally occluded by» a black screen at the moment of foot-ball- contact.\nParticipants’ task was to verbally\\predict shots direction. After pre-test, participants were\nrandomly assigned to one of three-groups: Experimental (N = 13), placebo (N = 13)or control (N\n= 12).\n\nControl group did not\\receive any perceptual stimulation. Placebo group was given a DVD\ncontaining eight session of penalty kick shoot-outs’ television footages,,and participants were told\nthey would benefit from it by watching at least one movie sessionper week. Experimental group\nwas given asDVD containing eight training sessions, and participants were told exactly the same\nindication as the placebo group.\n\nNowconstraints were imposed to experimental and ‘placebo groups participants regarding the\nnumber of training (or placebo) sessions, but they-were suggested to practice at least once a\nweek (they reported the number of sessions ‘ona diary). Moreover, they were free to schedule\ntheir sessions according to their everyday activities." + }, + { + "id": 82029, + "strid": "810b2ec0-84fc-47ad-8921-a4a075506c62", + "image_id": 203690, + "image_name": "120748.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2526.411, + 2484.236, + 215.81500000000005, + 51.98500000000013 + ], + "priority": 18, + "parents": [ + 82037 + ], + "children": [ + 82031, + 82027, + 82026 + ], + "area": 6276201.156996, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 82027, + "strid": "98c840a6-10c6-4d94-a679-c7da91de636f", + "image_id": 203690, + "image_name": "120748.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1997.23, + 2545.26, + 1276.656, + 95.85800000000017 + ], + "priority": 19, + "parents": [ + 82029 + ], + "children": [], + "area": 5083469.6298, + "iscrowd": 0, + "segmentation": [], + "text": "Average number of attended sessions:\nExperimental group = 8,69(SD)= 2,49); placebo group = 8,23 (SD = 2,12)" + }, + { + "id": 82031, + "strid": "f65f8608-af18-4037-bf7c-1e01d6abe81e", + "image_id": 203690, + "image_name": "120748.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1923.347, + 2657.208, + 1428.7769999999998, + 680.1030000000001 + ], + "priority": 20, + "parents": [ + 82029 + ], + "children": [], + "area": 5110733.035176001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 82026, + "strid": "d826eee0-3fee-468d-8154-d1e319195389", + "image_id": 203690, + "image_name": "120748.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2036.444, + 3342.626, + 1189.5120000000002, + 159.0369999999998 + ], + "priority": 21, + "parents": [ + 82029 + ], + "children": [], + "area": 6807070.661944, + "iscrowd": 0, + "segmentation": [], + "text": "Experimental group pre- vs-post-test: t(12) = 6,93; p < 0,001\nExperimental group vs placebo,.group pos-test: t(24) = 1,82; p < 0,05\nExperimental group vs control group post-test : t((23) = 2,29; p < 0,05" + }, + { + "id": 82018, + "strid": "79db58a9-a643-4c80-99a5-3f726da4f3ef", + "image_id": 203690, + "image_name": "120748.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1587.786, + 3544.811, + 364.45600000000013, + 54.51899999999978 + ], + "priority": 22, + "parents": [ + 82037 + ], + "children": [ + 82024 + ], + "area": 5628401.278446, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 82024, + "strid": "945a65fb-61c6-4e3a-a68f-59fbb051fdf8", + "image_id": 203690, + "image_name": "120748.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 58.281, + 3617.129, + 3418.214, + 169.92999999999984 + ], + "priority": 23, + "parents": [ + 82018 + ], + "children": [], + "area": 210809.895249, + "iscrowd": 0, + "segmentation": [], + "text": "Results revealed a significant accuracy improvement between pre-test and post-test/only for experimental group participants, thus.indicating that even skilled goalkeepers can benefit from perceptual\ntrainings. Moreover, the same_outcome demonstrates the efficacy of the innovative “take-away” protocol proposed. Considering its effectiveness and its simple application, future studies should\ninvestigate in order to maximize the potential of this protocol." + }, + { + "id": 82019, + "strid": "71df6527-1595-442e-a1b2-ac43b3d74e79", + "image_id": 203690, + "image_name": "120748.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1297.597, + 3830.066, + 323.24800000000005, + 50.17000000000007 + ], + "priority": 24, + "parents": [ + 82037 + ], + "children": [ + 82025 + ], + "area": 4969882.151401999, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 82025, + "strid": "7cbbafd1-ca81-431f-9fc5-7230b5931d38", + "image_id": 203690, + "image_name": "120748.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 90.96, + 3889.453, + 2775.529, + 420.4689999999996 + ], + "priority": 25, + "parents": [ + 82019 + ], + "children": [], + "area": 353784.64488, + "iscrowd": 0, + "segmentation": [], + "text": "Diaz, G.J., Fajen, BeR., & Phillips, F. (2012). Anticipation from biological.motion: the goalkeeper problem. Journal of ExperimentahPsychology: Human Perception and Performance,\n38(4), 848-864:\n\nRyu, D., Kim,S., Abernethy, B., & Mann, D.L. (2013). Guiding attention aids the acquisition of anticipatory skill in novice soccer goalkeepers. Research Quarterly for Exercise,and\nSporty84(2), 252-262.\n\nSavelsbergh, G.J.P., van Gastel, P.J., & van Kampen,/P.M.)(2010). Anticipation of penalty kicking direction can ‘be improved by directing attentioni through perceptual learning.\nInternational Journal of Sport Psychology, 41, 24-41.\n\nWu, W.F., & Magill, R.A. (2011). Allowing learners.tocchoose: self-controlled practice schedules for learning.multiple movement patterns. Research Quarterly for.Exercise and sport,\n82(3), 449-457. /" + }, + { + "id": 61342, + "strid": "e60c2634-1749-410d-b749-7773961b1866", + "image_id": 202920, + "image_name": "11945.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 320.16, + 258.88, + 253.44, + 288.64 + ], + "priority": -1, + "parents": [], + "children": [ + 61314, + 61341, + 61315, + 61317, + 61335, + 61316 + ], + "area": 82883.0208, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61314, + "strid": "6a9eebc5-9326-4904-8039-6fbcd63339b0", + "image_id": 202920, + "image_name": "11945.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 592.92, + 96.193, + 2620.146, + 279.386 + ], + "priority": 1, + "parents": [ + 61342 + ], + "children": [], + "area": 57034.75356, + "iscrowd": 0, + "segmentation": [], + "text": "The Mega2R R package: Tools for accessing and\nprocessing common genetic data formats in R." + }, + { + "id": 61315, + "strid": "10fc51cf-17bb-48c5-8dfc-4357b3d4383f", + "image_id": 202920, + "image_name": "11945.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 594.667, + 390.616, + 2666.258, + 164.91899999999998 + ], + "priority": 2, + "parents": [ + 61342 + ], + "children": [], + "area": 232286.444872, + "iscrowd": 0, + "segmentation": [], + "text": "Daniel E. Weeks?2, Robert V. Baron’, Justin R. Stickel*\n\n‘Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 7Department of Biostatistics, Graduate School of Public\nHealth, University of Pittsburgh" + }, + { + "id": 61316, + "strid": "18c84797-990f-4349-a14b-88e4e77aaae2", + "image_id": 202920, + "image_name": "11945.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 488.203, + 598.432, + 278.86400000000003, + 87.85799999999995 + ], + "priority": 3, + "parents": [ + 61342 + ], + "children": [ + 61321, + 61323, + 61325, + 61322, + 61324, + 61320, + 61318, + 61319 + ], + "area": 292156.29769599997, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 61318, + "strid": "f1fd5068-6be9-464e-af12-24d555eb1209", + "image_id": 202920, + "image_name": "11945.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 100.223, + 715.546, + 889.102, + 220.52199999999993 + ], + "priority": 4, + "parents": [ + 61316 + ], + "children": [], + "area": 71714.166758, + "iscrowd": 0, + "segmentation": [], + "text": "What is Mega2:\nData reformatting tool in C++ for\ngenetic analysis!" + }, + { + "id": 61319, + "strid": "32ad7f14-a5dc-418e-a0e4-6ded8075617e", + "image_id": 202920, + "image_name": "11945.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 99.426, + 953.609, + 401.141, + 61.499000000000024 + ], + "priority": 5, + "parents": [ + 61316 + ], + "children": [], + "area": 94813.528434, + "iscrowd": 0, + "segmentation": [], + "text": "Input formats:" + }, + { + "id": 61320, + "strid": "3f395765-849c-4474-ae31-e04679a769fc", + "image_id": 202920, + "image_name": "11945.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 90.671, + 1021.725, + 1002.568, + 271.56499999999994 + ], + "priority": 6, + "parents": [ + 61316 + ], + "children": [], + "area": 92640.82747500001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61322, + "strid": "21d67e9d-a1a7-4a7a-9877-74f4785116fd", + "image_id": 202920, + "image_name": "11945.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 97.667, + 1355.16, + 979.0009999999999, + 144.019 + ], + "priority": 7, + "parents": [ + 61316 + ], + "children": [], + "area": 132354.41172, + "iscrowd": 0, + "segmentation": [], + "text": "Output formats/analysis programs:\n(Recently added)" + }, + { + "id": 61321, + "strid": "69764adb-7d42-4da4-a964-01b881d2f9bb", + "image_id": 202920, + "image_name": "11945.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 90.566, + 1513.721, + 1002.7649999999999, + 728.596 + ], + "priority": 8, + "parents": [ + 61316 + ], + "children": [], + "area": 137091.656086, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61323, + "strid": "997aa90f-18a3-4a65-b600-94255eece0a6", + "image_id": 202920, + "image_name": "11945.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 101.011, + 2325.996, + 820.138, + 289.69399999999996 + ], + "priority": 9, + "parents": [ + 61316 + ], + "children": [], + "area": 234951.181956, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61324, + "strid": "0530f37c-9a0f-4fed-86dd-f67dca7760fb", + "image_id": 202920, + "image_name": "11945.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 98.575, + 2644.963, + 945.4759999999999, + 381.05700000000024 + ], + "priority": 10, + "parents": [ + 61316 + ], + "children": [], + "area": 260727.22772500003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61325, + "strid": "8b7de08c-23ae-4b98-a1a4-9e47d9d75aa9", + "image_id": 202920, + "image_name": "11945.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 100.097, + 3044.791, + 812.903, + 450.61299999999983 + ], + "priority": 11, + "parents": [ + 61316 + ], + "children": [], + "area": 304774.444727, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61317, + "strid": "292c6c99-83b4-4302-807f-f0fb0f58e25c", + "image_id": 202920, + "image_name": "11945.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2065.371, + 598.194, + 340.645, + 88.36500000000001 + ], + "priority": 12, + "parents": [ + 61342 + ], + "children": [ + 61338, + 61328, + 61331, + 61330, + 61326, + 61329, + 61339, + 61332, + 61327, + 61333, + 61337, + 61336, + 61334 + ], + "area": 1235492.539974, + "iscrowd": 0, + "segmentation": [], + "text": "Mega2R" + }, + { + "id": 61326, + "strid": "f724341b-98f9-4250-88e1-d7fb1375f785", + "image_id": 202920, + "image_name": "11945.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1226.286, + 714.28, + 961.442, + 460.5640000000001 + ], + "priority": 13, + "parents": [ + 61317 + ], + "children": [], + "area": 875911.56408, + "iscrowd": 0, + "segmentation": [], + "text": "What is Mega2R:\n\nAn efficient pathway from many\ndata formats via a Mega2-created\ndatabase into R data frames. These\ndata can be easily used in other R\npackages and functions." + }, + { + "id": 61327, + "strid": "bb4aff7f-7e92-44d1-9a3a-f2c64c53f168", + "image_id": 202920, + "image_name": "11945.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1230.832, + 1196.956, + 940.1389999999999, + 138.38300000000004 + ], + "priority": 14, + "parents": [ + 61317 + ], + "children": [], + "area": 1473251.747392, + "iscrowd": 0, + "segmentation": [], + "text": "Input:\nMega2 SQLite3 database tables." + }, + { + "id": 61328, + "strid": "30309058-4047-4a9e-a1a2-2a00cd1d6f68", + "image_id": 202920, + "image_name": "11945.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1230.269, + 1434.04, + 907.9480000000001, + 60.289999999999964 + ], + "priority": 15, + "parents": [ + 61317 + ], + "children": [], + "area": 1764254.95676, + "iscrowd": 0, + "segmentation": [], + "text": "Example conversion to GenABEL:" + }, + { + "id": 61337, + "strid": 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+ "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgments: This work was supported by NIH grant RO1 GM076667 (PI: Weeks)" + }, + { + "id": 61341, + "strid": "bd382bc7-bbfb-403c-b4c6-0e1621beadc6", + "image_id": 202920, + "image_name": "11945.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 44.977, + 3838.527, + 348.925, + 57.41600000000017 + ], + "priority": 27, + "parents": [ + 61342 + ], + "children": [ + 61340 + ], + "area": 172645.42887899998, + "iscrowd": 0, + "segmentation": [], + "text": "References:" + }, + { + "id": 61340, + "strid": "af4e7c09-b86e-436a-9c08-f78acca7de13", + "image_id": 202920, + "image_name": "11945.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 43.135, + 3916.172, + 3203.07, + 349.4630000000002 + ], + "priority": 28, + "parents": [ + 61341 + ], + "children": [], + "area": 168924.07921999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 33984, + "strid": "51ffd204-114f-4830-ba4e-d220d6a9b54a", + 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"category_name": "Author Info", + "bbox": [ + 537.966, + 260.232, + 3745.1740000000004, + 247.748 + ], + "priority": 2, + "parents": [ + 33984 + ], + "children": [], + "area": 139995.96811200003, + "iscrowd": 0, + "segmentation": [], + "text": "1 1Anthony J. 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Floch®\n@Newmed Publishing Services, Chester, UK\n®'Newmed Publishing Services, Paris, France" + }, + { + "id": 53410, + "strid": "499be972-ddfc-4b30-8b93-3a15c859e7ae", + "image_id": 202600, + "image_name": "118931.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 215.399, + 966.102, + 379.54100000000005, + 56.32600000000002 + ], + "priority": 3, + "parents": [ + 53452 + ], + "children": [], + "area": 208097.404698, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 53411, + "strid": "fd7e05f6-037c-4240-9bba-ad8bc533fc04", + "image_id": 202600, + "image_name": "118931.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 217.25, + 1042.709, + 141.279, + 29.891000000000076 + ], + "priority": 4, + "parents": [ + 53452 + ], + "children": [ + 53414 + ], + "area": 226528.53025, + "iscrowd": 0, + "segmentation": [], + "text": "Objective" + }, + { + "id": 53414, + "strid": "3c960ecf-8977-480c-a94f-6a2168560094", + "image_id": 202600, + 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The data were limited to subject area ‘Medicine; source type Journals and publication date 01/01/2008 to 31/12/2012." + }, + { + "id": 53413, + "strid": "02481898-c82c-4aeb-8e97-746470115044", + "image_id": 202600, + "image_name": "118931.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 215.368, + 1245.968, + 118.226, + 28.90000000000009 + ], + "priority": 8, + "parents": [ + 53452 + ], + "children": [ + 53416 + ], + "area": 268341.636224, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 53416, + "strid": "afab8259-b34a-4118-9a15-2bf4f3db3ec9", + "image_id": 202600, + "image_name": "118931.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 215.284, + 1289.08, + 3110.515, + 138.952 + ], + "priority": 9, + "parents": [ + 53413 + ], + "children": [], + "area": 277518.29871999996, + "iscrowd": 0, + "segmentation": [], + "text": "The number of articles published across all journals (N=20788) grew annually from 3807 in 2008 to 4406 in 2012 (+15.7%). Of the ‘Big Four journals, NEJM published more articles (n=135) than The Lancet (n=102), BMJ (n=25) or JAMA (n=17). The average number\nof citations received by NEJM articles (n=232.30) was considerably greater than for The Lancet (n=151.75), JAMA (n=93.12) or BMJ (n=18.24). NEJM published 36 of the top 100 most cited articles followed by The Lancet (n=19), JAMA (n=1) and BMJ (n=0). PLoS\nONE published more articles than any other journal (n=577) and grew in publication output by 451.1%. Articles published in other gold open-access journals from PLoS and BioMed Central’s ‘BMC series (n=48) grew from 88 to 114 (+29.6%). The number of articles\npublished in general medical journals renowned for their rapid publishing services peaked in 2009 at 169 and then decreased steadily to 100 in 2012." + }, + { + "id": 53417, + "strid": "c6f8d33f-9f4e-488c-b4fd-4c9b7a40744f", + "image_id": 202600, + "image_name": "118931.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 218.925, + 1445.435, + 181.62899999999996, + 28.463999999999942 + ], + "priority": 10, + "parents": [ + 53452 + ], + "children": [ + 53418 + ], + "area": 316441.857375, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 53418, + "strid": "1b8d27be-ab72-4b26-bff1-40fe9ca46633", + "image_id": 202600, + "image_name": "118931.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 216.706, + 1486.456, + 3148.929, + 68.70399999999995 + ], + "priority": 11, + "parents": [ + 53417 + ], + "children": [], + "area": 322123.933936, + "iscrowd": 0, + "segmentation": [], + "text": "The number of articles published anually with top-10 pharmaceutical company authors is steadily increasing. The use of general medical journals specialising in rapid publication is decreasing, while the use of well established gold open-access journals is increasing, with\nPLoS ONE accounting for the majority of that growth. NEJM publishes the highest impact articles, by a considerable margin." + }, + { + "id": 53419, + "strid": "c551f020-cc01-496d-83ce-ce7cb3157a9d", + "image_id": 202600, + "image_name": "118931.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 218.232, + 1673.23, + 390.179, + 56.090999999999894 + ], + "priority": 12, + "parents": [ + 53452 + ], + "children": [ + 53420 + ], + "area": 365152.32936, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 53420, + "strid": "b266ddc0-6c19-465f-b3b6-c66b48978359", + "image_id": 202600, + "image_name": "118931.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 205.971, + 1745.778, + 1494.9, + 554.7279999999998 + ], + "priority": 13, + "parents": [ + 53419 + ], + "children": [], + "area": 359579.64043800003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 53424, + "strid": "51c0db80-4aca-4d83-9aec-694136628278", + "image_id": 202600, + "image_name": "118931.png", + "category_id": 5, + 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202600, + "image_name": "118931.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 170.621, + 4712.829, + 1503.499, + 102.99799999999959 + ], + "priority": 19, + "parents": [ + 53449 + ], + "children": [], + "area": 804107.596809, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1: Number of articles published per annum with authors from top-10 pharmaceutical\ncompanies" + }, + { + "id": 53447, + "strid": "427bf80b-727c-4fde-816f-c3f39f87ebb8", + "image_id": 202600, + "image_name": "118931.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 171.214, + 4845.312, + 1579.139, + 360.5069999999996 + ], + "priority": 20, + "parents": [ + 53451 + ], + "children": [], + "area": 829585.2487679999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 53445, + "strid": "dbc1a335-ca20-42c5-b28e-b02ea652630b", + "image_id": 202600, + "image_name": "118931.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 176.969, + 5351.999, + 1564.631, + 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+ "priority": 28, + "parents": [ + 53423 + ], + "children": [], + "area": 3443090.889875, + "iscrowd": 0, + "segmentation": [], + "text": "Table 3: General medical journals with >10 articles, ranked by average number of citations\nreceived per article published (2008-12)" + }, + { + "id": 53426, + "strid": "c022ab03-fa95-401c-993e-c8908efc36a2", + "image_id": 202600, + "image_name": "118931.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1814.282, + 3227.983, + 1582.514, + 276.6300000000001 + ], + "priority": 29, + "parents": [ + 53451 + ], + "children": [], + "area": 5856471.453206, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 53427, + "strid": "15d2f673-23c3-41c6-98c7-3c44be5f2112", + "image_id": 202600, + "image_name": "118931.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1820.727, + 3536.877, + 1565.227, + 786.2040000000002 + ], + "priority": 30, + "parents": [ + 53451 + ], + "children": [ + 53428 + ], + "area": 6439687.4495790005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 53428, + "strid": "45fa3dad-9657-4836-b439-6c0903840d86", + "image_id": 202600, + "image_name": "118931.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1815.203, + 4330.749, + 1518.091, + 44.97999999999956 + ], + "priority": 31, + "parents": [ + 53427 + ], + "children": [], + "area": 7861188.577047, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2: Number of articles published in PLoS journals and BioMed Central’s BMC journals" + }, + { + "id": 53429, + "strid": "83105d6d-b721-437e-960e-735590a662d4", + "image_id": 202600, + "image_name": "118931.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1817.209, + 4411.695, + 1506.142, + 165.8710000000001 + ], + "priority": 32, + "parents": [ + 53451 + ], + "children": [], + "area": 8016971.859255, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 53430, + "strid": "915f9c8f-eb1f-478a-8697-363036c1fcba", + "image_id": 202600, + "image_name": "118931.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1820.996, + 4609.814, + 1565.071, + 788.0339999999997 + ], + "priority": 33, + "parents": [ + 53451 + ], + "children": [ + 53431 + ], + "area": 8394452.854744, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 53431, + "strid": "60788679-3831-43e0-babb-bb7db632d9fe", + "image_id": 202600, + "image_name": "118931.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1814.742, + 5409.464, + 1423.9259999999997, + 102.79699999999957 + ], + "priority": 34, + "parents": [ + 53430 + ], + "children": [], + "area": 9816781.518288, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3: Number of articles published in general medical journals specialising in rapid\npublication (2008-12)" + }, + { + "id": 53432, + "strid": "8d673a1c-2730-4f0a-b5b1-52fe36e44ab5", + "image_id": 202600, + "image_name": "118931.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 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"text": "" + }, + { + "id": 53435, + "strid": "9bce3360-0dc1-4f4a-b29b-fc922f0ae1a3", + "image_id": 202600, + "image_name": "118931.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1814.817, + 6508.355, + 1576.8379999999997, + 242.7470000000003 + ], + "priority": 38, + "parents": [ + 53434 + ], + "children": [], + "area": 11811473.296035, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 53436, + "strid": "f3716be0-02bc-4877-b347-df94e575ab78", + "image_id": 202600, + "image_name": "118931.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1819.083, + 6783.311, + 875.1599999999999, + 72.27000000000044 + ], + "priority": 39, + "parents": [ + 53452 + ], + "children": [ + 53437 + ], + "area": 12339405.723813, + "iscrowd": 0, + "segmentation": [], + "text": "CONFLICTS OF INTEREST" + }, + { + "id": 53437, + "strid": "21bf2c0f-e441-45db-a2a2-22f8ce7ea8ba", + "image_id": 202600, + "image_name": "118931.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1812.95, + 6866.219, + 1455.501, + 149.1840000000002 + ], + "priority": 40, + "parents": [ + 53436 + ], + "children": [], + "area": 12448111.73605, + "iscrowd": 0, + "segmentation": [], + "text": "The authors are employees of Newmed Publishing Services, a supplier to all of the top-10\npharmaceutical companies. The authors have no conflicting interest relating to Scopus or any\nmedical journal." + }, + { + "id": 53440, + "strid": "60faf777-5540-47ed-bd2d-8c149d31d429", + "image_id": 202600, + "image_name": "118931.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1817.77, + 7308.456, + 402.66600000000017, + 55.74200000000019 + ], + "priority": 41, + "parents": [ + 53452 + ], + "children": [ + 53441 + ], + "area": 13285092.06312, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 53441, + "strid": "0195e8be-48b5-4722-b04f-b05f1da41be0", + "image_id": 202600, + "image_name": "118931.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1816.144, + 7388.122, + 264.83400000000006, + 135.3819999999996 + ], + "priority": 42, + "parents": [ + 53440 + ], + "children": [], + "area": 13417893.441568, + "iscrowd": 0, + "segmentation": [], + "text": "Journals\nLiterature search\nMetrics" + }, + { + "id": 53438, + "strid": "4eecf7f1-2e39-467a-85fd-c3d05184bfe5", + "image_id": 202600, + "image_name": "118931.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1817.742, + 7047.463, + 470.49, + 59.28399999999965 + ], + "priority": 43, + "parents": [ + 53452 + ], + "children": [ + 53439 + ], + "area": 12810469.488545999, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 53439, + "strid": "c21da69e-2a30-4d6f-8f0d-aa2c3cebda61", + "image_id": 202600, + "image_name": "118931.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1816.795, + 7128.376, + 1408.348, + 140.28999999999996 + ], + "priority": 44, + "parents": [ + 53438 + ], + "children": [], + "area": 12950797.874920001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 28516, + "strid": "4ecd85d3-6fd5-494e-a89a-1341e047f916", + "image_id": 201625, + "image_name": "117414.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 53.33, + 3.48, + 96.04, + 54.57 + ], + "priority": -1, + "parents": [], + "children": [ + 28513, + 28499, + 28504, + 28502, + 28512, + 28500, + 28501, + 28503 + ], + "area": 185.5884, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 28499, + "strid": "88ba9d34-0f20-49b9-9c31-b685ae37bbc7", + "image_id": 201625, + "image_name": "117414.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 10.811, + 78.147, + 639.569, + 42.092 + ], + "priority": 1, + "parents": [ + 28516 + ], + "children": [], + "area": 844.847217, + "iscrowd": 0, + "segmentation": [], + "text": "ACCESSIBILITY TO THE TREATMENT OF CHRONIC BENIGN PAIN.\nSURVEY INTO ITALLAN PAIN CLINICS." + }, + { + "id": 28500, + "strid": "70c44cc3-6805-4185-8da3-d792820accf2", + "image_id": 201625, + "image_name": "117414.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 16.916, + 153.942, + 803.745, + 97.84300000000002 + ], + "priority": 2, + "parents": [ + 28516 + ], + "children": [], + "area": 2604.0828720000004, + "iscrowd": 0, + "segmentation": [], + "text": "Se ee cn ee ee ee ee A (1), Cattaruzza MS (1), Mastroianni C/(4), Notaro P (5), Casale\nCY Nnen AMON EO te tN ocd)\n\nOR NU eam RR ear) EM a RR on aidan\nON rN NE a Lae TT CRC oe ere MMM tee eM oe\nOR erat eee as At en ee a ea\neal 2 Ai sll aerial gael sagt ce BS." + }, + { + "id": 28501, + "strid": "30d407c7-de22-4473-a969-48b4d02098af", + "image_id": 201625, + "image_name": "117414.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 30.577, + 262.134, + 81.717, + 14.961999999999989 + ], + "priority": 3, + "parents": [ + 28516 + ], + "children": [ + 28505 + ], + "area": 8015.271318000001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 28505, + "strid": "17bbcda2-b4db-4194-86bd-496f384c78c4", + "image_id": 201625, + "image_name": "117414.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 30.316, + 281.422, + 243.155, + 593.12 + ], + "priority": 4, + "parents": [ + 28501 + ], + "children": [], + "area": 8531.589352, + "iscrowd": 0, + "segmentation": [], + "text": "Chronic pain is one of the most sig-\nnificant causes of suffering at European\nand Worldwide level, it has a significant\neconomic impact on those affected\nmaking them unable to work (Breivick\net al, 2006; Blyth et al., 2001)\n\nPain management should involve a\nholistic approach focusing on patients,\nwho experience acute andlor chronic\npain and their fanilies. Cooper etal\n(2003) describe how patients with\nchronic musculoskeletal pain have\nnegative experiences with a traditional\nmodel of care; they often consult sev-\neral specialists (including orthopaedic\nsurgeons, pain anaesthetists, rheuma-\ntologists and physiotherapists but re-\nceive little or no practical advices on\nmanaging their symptoms\n\nIn taly, charities which support\nchronic patients (Cittadinanzattiva,\n2009) have called attention to obsta-\ncles in obtaining pain therapy in Pain\nClinics where physicians play a key\nrole in starting all therapeutic proc-\nesses for obtaining relief from pain.\nFurthermore, often the first consulted\nphysician needs time to give to patient\ntailor made information about pain clin-\nics, this leads to a delay, even of\nmonths, in pain management." + }, + { + "id": 28504, + "strid": "5cf696b0-9327-4306-a69f-8236d39bd17f", + "image_id": 201625, + "image_name": "117414.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 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"iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 28506, + "strid": "86fd5e1a-8e88-4496-a4e2-24f9a3368971", + "image_id": 201625, + "image_name": "117414.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 490.896, + 289.007, + 306.30699999999996, + 95.83300000000003 + ], + "priority": 10, + "parents": [ + 28502 + ], + "children": [], + "area": 141872.380272, + "iscrowd": 0, + "segmentation": [], + "text": "19.8% of cases were referred to the pain clinics\nby their GP, 45% by the specialist, and 38% on\nthe patient’ initiative or following the advice of\nfiends. 72.7% of the later group are patients who\nattended a regional health centre." + }, + { + "id": 28509, + "strid": "465ad32d-4443-432c-bd7c-2c7d78342621", + "image_id": 201625, + "image_name": "117414.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 546.187, + 388.871, + 196.06000000000006, + 129.62199999999996 + ], + "priority": 11, + "parents": [ + 28502 + ], + "children": [], + "area": 212396.284877, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 28515, + "strid": "e3490cb0-f0c6-4add-a5d2-c663bf2d067f", + "image_id": 201625, + "image_name": "117414.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 491.091, + 520.593, + 299.587, + 14.277000000000044 + ], + "priority": 12, + "parents": [ + 28502 + ], + "children": [], + "area": 255658.536963, + "iscrowd": 0, + "segmentation": [], + "text": "DU Ce A ee ae ea ae Le" + }, + { + "id": 28503, + "strid": "b65144b2-bab9-4803-8bb1-df349290b955", + "image_id": 201625, + "image_name": "117414.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 287.154, + 541.402, + 74.35000000000002, + 15.82899999999995 + ], + "priority": 13, + "parents": [ + 28516 + ], + "children": [ + 28507 + ], + "area": 155465.749908, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 28507, + "strid": "c1d4a205-6188-4f23-8ca1-c9cac1128bed", + "image_id": 201625, + "image_name": "117414.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 285.733, + 560.887, + 507.796, + 382.794 + ], + "priority": 14, + "parents": [ + 28503 + ], + "children": [], + "area": 160263.92517099998, + "iscrowd": 0, + "segmentation": [], + "text": "Despite the high prevalence of chronic pain in the general population, surprisingly\nitl is known about the impact of chronic pain on the total access of Pain Clinic\n(PC). As preliminary, itis interesting note that just a litle percentage of patients are\nin the Pain Clinics following GPs’ indications. According to Stannard et al, (2003) in\nchronic therapeutic process, G.Ps. health care can be insufficient; pain is generally\nperceived by patients as a symptom of an illness clearly identified, however as re-\ncalled by Varassi and colleagues (2011) chronic pain in several cases is not a\nsymptom but is a illness in itself. In the light of above a number of patients are in\nPC following specialists’ indication this drives to think that several patients have\nbeen kept waiting months and even years before then access to PC. The so called\n“pass the word\" seems to be important in order to exchange information on the\nsubject. G.P. often is not the first person who address properly the patient towards\nan effective treatment; this is due to two main factors: ie. culture and education\n(Joint Commission International, 2010) and the fact that PC net pain therapy is not\nwell known and framed properly in Lazio Region. It could be said that the role of a\nGP or Nurse in referring patients for pain therapy is not instrumental; this could be\nattributed to the high labour costs involved or to a lack of awareness about the ser-\nvices offer. When a referral is made by a specialist, there can be delays in treating\npain. A more detailed, large scale survey is perhaps required to map the availablity\nof chronic pain services." + }, + { + "id": 28512, + "strid": "207a29f3-bca5-40a6-b39d-f858c587ae3a", + "image_id": 201625, + "image_name": "117414.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 287.083, + 966.908, + 83.41699999999997, + 15.600999999999999 + ], + "priority": 15, + "parents": [ + 28516 + ], + "children": [ + 28511 + ], + "area": 277582.849364, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 28511, + "strid": "3a15cdd0-c2ff-4445-bada-68ed107454bb", + "image_id": 201625, + "image_name": "117414.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 286.186, + 986.602, + 507.233, + 75.3080000000001 + ], + "priority": 16, + "parents": [ + 28512 + ], + "children": [], + "area": 282351.67997199995, + "iscrowd": 0, + "segmentation": [], + "text": "‘There is a continuing cultural barrier species among health care professionals to\nconsider chronic pain as a symptom and not a disease. This problem increases the\ntime of an effective treatment. The figure of the GP and the nurse may be key in\nthe orientation of these patients." + }, + { + "id": 28513, + "strid": "248cfcd4-deeb-42c0-a822-52f649f1adde", + "image_id": 201625, + "image_name": "117414.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 26.787, + 1077.105, + 123.6, + 18.590999999999894 + ], + "priority": 17, + "parents": [ + 28516 + ], + "children": [ + 28514 + ], + "area": 28852.411635, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgement" + }, + { + "id": 28514, + "strid": "e23399a1-3f98-48dd-ad93-d5ec6635cbd9", + "image_id": 201625, + "image_name": "117414.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 33.466, + 1096.917, + 437.25, + 31.220000000000027 + ], + "priority": 18, + "parents": [ + 28513 + ], + "children": [], + "area": 36709.424322, + "iscrowd": 0, + "segmentation": [], + "text": "Prof. lsaac Benabu, PhD, The Hebrew University of Jerusalem, Israel.\nFerdinant Banda, Bsc Universiteti Katolik Zoia e Keshillit te Mire, Tirana, Albany" + }, + { + "id": 192501, + "strid": "567cc478-b9b7-4ca6-96cc-cbd334e8e5ff", + "image_id": 208018, + "image_name": "9236.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 18.26, + 9.43, + 66.44, + 26.939999999999998 + ], + "priority": -1, + "parents": [], + "children": [ + 192482, + 192485, + 192483, + 192486, + 192487, + 192481, + 192484 + ], + "area": 172.1918, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 192482, + "strid": "438bbe43-8f29-4b73-a04e-698c63baa04e", + "image_id": 208018, + "image_name": "9236.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 40.508, + 115.071, + 601.161, + 72.80800000000002 + ], + "priority": 1, + "parents": [ + 192501 + ], + "children": [], + "area": 4661.296068000001, + "iscrowd": 0, + "segmentation": [], + "text": "ALDOSTERONE LEVELS IN PATIENTS ON HEMODIALYSIS:\nRELATIONSHIP WITH INSULIN RESISTENCE, BODY MASS AND\nADIPOCITOKINES." + }, + { + "id": 192481, + "strid": "cf67881e-5b7b-4842-ba73-78ef9296728a", + "image_id": 208018, + "image_name": "9236.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 40.601, + 193.93, + 683.689, + 96.40199999999999 + ], + "priority": 2, + "parents": [ + 192501 + ], + "children": [], + "area": 7873.75193, + "iscrowd": 0, + "segmentation": [], + "text": "Fernandez -Reyes MJ (1), Heras M (1), Gonzalez MJ (2), Rodriguez O (2),\nCallejas R (1), Molina A (1), Rodriguez MA (1), Lopes V, Calle L (1).\n\n(1) Department Nephrology, Segovia Hospital General, (2) Department\nBiochemistry, La Paz Hospital, Madrid, SPAIN" + }, + { + "id": 192486, + "strid": "426dae4f-50f2-4285-bf49-c9daa067b8f1", + "image_id": 208018, + "image_name": "9236.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 46.464, + 307.296, + 117.25900000000001, + 21.03000000000003 + ], + "priority": 3, + "parents": [ + 192501 + ], + "children": [ + 192495 + ], + "area": 14278.201344, + "iscrowd": 0, + "segmentation": [], + "text": "Background:" + }, + { + "id": 192495, + "strid": "7c35f475-b597-4ff3-a31b-75522efd8423", + "image_id": 208018, + "image_name": "9236.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 45.577, + 329.916, + 303.943, + 87.19200000000001 + ], + "priority": 4, + "parents": [ + 192486 + ], + "children": [], + "area": 15036.581532, + "iscrowd": 0, + "segmentation": [], + "text": "Patients with chronic renal disease (CKD) and\ndialysis are high incidence of insulin resistance.\nRecently it has been shown that serum aldosterone\n(SA) levels are correlated with insulin resistance;\nexcess body fat and serum levels of\nadipocitokines." + }, + { + "id": 192485, + "strid": "6036a6a9-2926-485c-9399-d5dbac4f967c", + "image_id": 208018, + "image_name": "9236.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 45.666, + 437.111, + 94.62099999999998, + 19.488999999999976 + ], + "priority": 5, + "parents": [ + 192501 + ], + "children": [ + 192493 + ], + "area": 19961.110925999998, + "iscrowd": 0, + "segmentation": [], + "text": "Objective:" + }, + { + "id": 192493, + "strid": "95f6981e-8356-4cde-84bf-3ed8ed997a8c", + "image_id": 208018, + "image_name": "9236.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 45.467, + 458.588, + 299.651, + 72.96200000000005 + ], + "priority": 6, + "parents": [ + 192485 + ], + "children": [], + "area": 20850.620596, + "iscrowd": 0, + "segmentation": [], + "text": "eet eet ets TearaseceeeereccereL eeee eette ener eee\n(HD and its possible association with insulin\nresistance (HOMA), excess body _ fat\n(bioimpedance) and/or serum adipocitokines\nlevels." + }, + { + "id": 192484, + "strid": "609788b4-7679-46f6-8822-f90789f3ddad", + "image_id": 208018, + "image_name": "9236.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 44.746, + 536.863, + 203.773, + 19.423999999999978 + ], + "priority": 7, + "parents": [ + 192501 + ], + "children": [ + 192489, + 192494, + 192500 + ], + "area": 24022.471798000002, + "iscrowd": 0, + "segmentation": [], + "text": "Patients and Methods:" + }, + { + "id": 192494, + "strid": "e834b416-8eb8-460f-bd42-153444bca977", + "image_id": 208018, + "image_name": "9236.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 45.599, + 559.38, + 314.495, + 72.10400000000004 + ], + "priority": 8, + "parents": [ + 192484 + ], + "children": [], + "area": 25507.168619999997, + "iscrowd": 0, + "segmentation": [], + "text": "28 no diabetic stable patients on HD, not taking ACE\ninhibitorsfangiotensin receptor blockers.\n\n18 patients were anuric.\n\nAll measurements were done prior to the midweek HD\naaaina" + }, + { + "id": 192489, + "strid": "4fba09d2-c6a2-49df-8704-0822b059e0ed", + "image_id": 208018, + "image_name": "9236.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 47.224, + 669.123, + 262.695, + 360.12799999999993 + ], + "priority": 9, + "parents": [ + 192484 + ], + "children": [ + 192498 + ], + "area": 31598.664552, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 192498, + "strid": "3617eb71-51f8-4fb5-9fdd-f3fccb7efca5", + "image_id": 208018, + "image_name": "9236.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 44.257, + 637.838, + 240.23399999999998, + 28.164999999999964 + ], + "priority": 10, + "parents": [ + 192489 + ], + "children": [], + "area": 28228.796366, + "iscrowd": 0, + "segmentation": [], + "text": "Ipiurssadisahenerwnepeten.cie sete Saneapmentaacanl\neiieneneiie dearbalainn" + }, + { + "id": 192500, + "strid": "0a03f358-a34a-45ad-9017-ba1429786217", + "image_id": 208018, + "image_name": "9236.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 46.95, + 1041.874, + 126.77899999999998, + 23.374000000000024 + ], + "priority": 11, + "parents": [ + 192484 + ], + "children": [], + "area": 48915.984300000004, + "iscrowd": 0, + "segmentation": [], + "text": "lege rah cheeaicanl\ndutaeditee" + }, + { + "id": 192487, + "strid": "ce45a780-0116-40b9-99b1-4ea01d831c74", + "image_id": 208018, + "image_name": "9236.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 390.973, + 300.105, + 81.72899999999998, + 19.057999999999993 + ], + "priority": 12, + "parents": [ + 192501 + ], + "children": [ + 192488, + 192491, + 192496, + 192490, + 192499 + ], + "area": 117332.95216500001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 192496, + "strid": "d6b4e1f0-07ae-4762-a930-d198f6ba0971", + "image_id": 208018, + "image_name": "9236.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 391.311, + 323.571, + 352.03799999999995, + 71.27800000000002 + ], + "priority": 13, + "parents": [ + 192487 + ], + "children": [], + "area": 126616.891581, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 192488, + "strid": "3b047a29-a595-4ae9-97d9-1a8211b6edf0", + "image_id": 208018, + "image_name": "9236.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 391.544, + 431.607, + 340.033, + 184.79900000000004 + ], + "priority": 14, + "parents": [ + 192487 + ], + "children": [ + 192497 + ], + "area": 168993.131208, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 192497, + "strid": "6d4eaddd-d474-45c4-9563-6fb7cf2680c9", + "image_id": 208018, + "image_name": "9236.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 387.719, + 407.808, + 295.44, + 16.360000000000014 + ], + "priority": 15, + "parents": [ + 192488 + ], + "children": [], + "area": 158114.909952, + "iscrowd": 0, + "segmentation": [], + "text": "Table 2. Means and medians values hormone tests" + }, + { + "id": 192499, + "strid": "611a8a25-8ab7-4c3d-ace4-cc31ffea6c3e", + "image_id": 208018, + "image_name": "9236.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 391.855, + 625.203, + 343.043, + 31.519000000000005 + ], + "priority": 16, + "parents": [ + 192487 + ], + "children": [], + "area": 244988.921565, + "iscrowd": 0, + "segmentation": [], + "text": "ee ee ee ee\nHomeostasis model assessoment index of Inauln resistence = gicose (mmol\niauin quite" + }, + { + "id": 192490, + "strid": "65ff7846-7139-4d70-be5f-5cfe23d4efdf", + "image_id": 208018, + "image_name": "9236.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 385.402, + 683.012, + 346.84600000000006, + 191.07100000000003 + ], + "priority": 17, + "parents": [ + 192487 + ], + "children": [], + "area": 263234.190824, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 192491, + "strid": "b9ef3e89-2ee1-4fa8-8934-906417e45a4b", + "image_id": 208018, + "image_name": "9236.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 371.866, + 878.816, + 343.03, + 56.26099999999997 + ], + "priority": 18, + "parents": [ + 192487 + ], + "children": [], + "area": 326801.790656, + "iscrowd": 0, + "segmentation": [], + "text": "Mul\n\n \n\nariate lineal regression analysis model\n\nThe best model to explain SA levels included ARP and HOMA.IR\n(0.78 r2=0.61)" + }, + { + "id": 192483, + "strid": "f1e477d6-151f-4753-917a-e2ae68bc23bf", + "image_id": 208018, + "image_name": "9236.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 384.061, + 967.342, + 111.87799999999999, + 18.762000000000057 + ], + "priority": 19, + "parents": [ + 192501 + ], + "children": [ + 192492 + ], + "area": 371518.33586199995, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 192492, + "strid": "d27fd924-9f71-4b49-b1a0-fd013a0c767b", + "image_id": 208018, + "image_name": "9236.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 383.587, + 988.326, + 336.04099999999994, + 59.28099999999995 + ], + "priority": 20, + "parents": [ + 192483 + ], + "children": [], + "area": 379109.005362, + "iscrowd": 0, + "segmentation": [], + "text": "SA levels are elevated in a high percentage of HD\npatients. Such elevation is independently associated\nwith PRA and insulin resistance; and correlated with\nbody fat mass; and serum levels of adipocitokine." + }, + { + "id": 179763, + "strid": "be314a6b-2e67-4963-bf14-b8a7911738de", + "image_id": 207521, + "image_name": "8352.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 569.97, + 174.26, + 235.98000000000002, + 208.75 + ], + "priority": -1, + "parents": [], + "children": [ + 179757, + 179750, + 179753, + 179759, + 179752, + 179762, + 179756, + 179758, + 179751 + ], + "area": 99322.9722, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 179750, + "strid": "c9f8431c-fe06-44ca-a359-f5bd94cc24ba", + "image_id": 207521, + "image_name": "8352.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 954.483, + 156.632, + 3223.4629999999997, + 201.94800000000004 + ], + "priority": 1, + "parents": [ + 179763 + ], + "children": [], + "area": 149502.581256, + "iscrowd": 0, + "segmentation": [], + "text": "EFFECTS OF CHRONIC OPTOGENETIC STIMULATION ON HEBBIAN\nPLASTICITY IN THE MOUSE HIPPOCAMPUS" + }, + { + "id": 179751, + "strid": "ce7199d2-c5bb-4661-911b-0f3ace4ae15c", + "image_id": 207521, + "image_name": "8352.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 901.09, + 424.015, + 2919.255, + 117.82600000000002 + ], + "priority": 2, + "parents": [ + 179763 + ], + "children": [], + "area": 382075.67635, + "iscrowd": 0, + "segmentation": [], + "text": "Thiago C Moulin'; Olavo B Amaral'; Katarina E Leao?; Richardson N Leao?\n‘Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro; 2 Brain Institute, Federal University of Rio Grande do Norte" + }, + { + "id": 179752, + "strid": "c55f7c9c-f3a1-47dc-854c-176e25944c7c", + "image_id": 207521, + "image_name": "8352.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 192.623, + 607.852, + 4390.33, + 181.27200000000005 + ], + "priority": 3, + "parents": [ + 179763 + ], + "children": [], + "area": 117086.27579599999, + "iscrowd": 0, + "segmentation": [], + "text": "Introductioin: In order to keep their activity constant, neurons are capable of altering their synaptic properties according to their overall degree of excitation and/or firing rate, thus regulating their excitability. This form of homeostatic plasticity, known as\nsynaptic scaling, is thought to be necessary to maintain neuronal network stability. Additionally, it is widely accepted that memories are formed by changes induced by activity at specific synapses, using processes such as long term potentiation (LTP) and\nlong term depression (LTD). Despite the importance of both homeostatic and synaptic plasticity, details of how they influence each other are still unknown. With that in mind, we developed a model to try to alter neuronal excitability in vivo using chronic\noptogenetic stimulation of pyramidal cells in the CA1 region of the hippocampus of C57BL/6 mice. We then evaluated the effect of this intervention on synaptic plasticity in ex vivo brain slices." + }, + { + "id": 179753, + "strid": "bd055d64-f138-454b-8f3e-68a18c17e896", + "image_id": 207521, + "image_name": "8352.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 193.77, + 841.672, + 4386.775, + 226.942 + ], + "priority": 4, + "parents": [ + 179763 + ], + "children": [], + "area": 163090.78344, + "iscrowd": 0, + "segmentation": [], + "text": "Methods: We first demonstrated that 15 ms of acute optical stimulation on 473nm frequency was capable of increasing neuronal firing rate in slices expressing channelrhodopsin 2 (ChR2), demonstrating the efficacy of its transfection by an\nadenoassociated virus under the a-CaMkKII promoter. We then applied the same stimulus in freely moving animals every 90 seconds during 24 hours; after that, we sacrificed the animals and prepared hippocampal slices, in which we recorded the field\nevoked post-synaptic potential ((EPSPs) in the stratum radiatum of CA1 in response to electrical pulses applied on the Schaffer collaterals. Using a weak theta burst protocol (2 bursts of 4 pulses at 100Hz, 200ms apart) we were able to induce LTD in the\nfEPSPs of slices of mice that underwent chronic optogenetic stimulation. However, the same protocol did not have an effect in slices where ChR2 was not expressed. When we applied a strong theta burst protocol (20 bursts of 4 pulses at 100Hz, 200ms\napart), a potentiation was observed in the control group fEPSPs, but not in the slices expressing ChR2." + }, + { + "id": 179756, + "strid": "2bfbb778-a7f3-4550-9e71-d397a9014d1e", + "image_id": 207521, + "image_name": "8352.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 213.98, + 1218.94, + 1144.043, + 518.0810000000001 + ], + "priority": 5, + "parents": [ + 179763 + ], + "children": [ + 179755 + ], + "area": 260828.7812, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 179755, + "strid": "e26c40ef-4b5b-43ba-948f-24a6388570d6", + "image_id": 207521, + "image_name": "8352.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 193.976, + 1794.528, + 1179.0719999999997, + 233.27199999999993 + ], + "priority": 6, + "parents": [ + 179756 + ], + "children": [], + "area": 348095.363328, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. ChR2 Expression. Qualitative examples of ChR2 expression under\nthe a-CaMkIl promoter, as shown by association with Yellow Fluorescent\nProtein (YFP), and observation under confocal microscopy in hippocampal\nslices. (A) Expression in a pyramidal cell of the CA1 region (B) Dentate gyrus\nexcitatory cells expressing YFP. We can note that there are several cells\nexpressingYFP in soma, but there are also some with dendritic expression" + }, + { + "id": 179759, + "strid": "51d68820-c3f2-4cac-a7be-dc1fcc444a05", + "image_id": 207521, + "image_name": "8352.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 87.214, + 2331.042, + 431.4270000000001, + 574.3969999999999 + ], + "priority": 7, + "parents": [ + 179763 + ], + "children": [ + 179760 + ], + "area": 203299.496988, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 179760, + "strid": "50c1c4f6-db31-45ab-b1a3-97fdc65c8101", + "image_id": 207521, + "image_name": "8352.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 590.145, + 2390.109, + 781.8020000000001, + 352.3409999999999 + ], + "priority": 8, + "parents": [ + 179759 + ], + "children": [], + "area": 1410510.8758049998, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2. Local increase activity induced by\noptical stimulation. 15 ms of acute optical\nstimulation at a 473nm frequency was capable of\nincreasing the neuronal firing rate of slices\nexpressing channelrhodopsin 2 (ChR2). We\nevaluated the frequency of action potentials 1 s\nbefore and 1 s after the stimulus. Acute stimulation\nsignificantly increased the firing rate. (n=7 slices;\nPaired t test p=0.013)" + }, + { + "id": 179757, + "strid": "8ae6339a-d802-43a3-8f55-a71a15f4d2e1", + "image_id": 207521, + "image_name": "8352.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1551.292, + 1221.501, + 1245.884, + 926.3010000000002 + ], + "priority": 9, + "parents": [ + 179763 + ], + "children": [ + 179761 + ], + "area": 1894904.729292, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 179761, + "strid": "cc7bfdad-25c5-41b1-a3d5-e4ee5a799a46", + "image_id": 207521, + "image_name": "8352.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1608.98, + 2291.858, + 1090.5989999999997, + 513.192 + ], + "priority": 10, + "parents": [ + 179757 + ], + "children": [], + "area": 3687553.6848400002, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3. Hebbian plasticity modulation with weak theta burst\nprotocol. We applied 15ms stimuli in freely moving animals every 90\nseconds during 24 hours; after that, we sacrificed the animals and\nprepared hippocampal slices, in which we recorded the field evoked post-\nsynaptic potential (fEPSPs) in the stratum radiatum of CA1 in response to\nelectrical pulses applied on the Schaffer collaterals. On the left we see\nthe recording 10 min before and 30 min after a weak theta burst protocol\n(2 bursts of 4 pulses at 100Hz, 200ms apart); on the right is the mean\namplitude change in each group compared to baseline. We were able to\ninduce LTD in the EPSPs responses of slices of mice that underwent\nchronic optogenetic stimulation through the weak theta burst. However,\nthe same protocol did not have an effect on slices where ChR2 was not\nexpressed. (n control=3, CA1=5; Student’s t test; p = 0.0131)" + }, + { + "id": 179758, + "strid": "edfdf580-0719-44d6-b705-3456f16ce0a6", + "image_id": 207521, + "image_name": "8352.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3052.055, + 1245.84, + 1310.0180000000005, + 547.367 + ], + "priority": 11, + "parents": [ + 179763 + ], + "children": [ + 179754 + ], + "area": 3802372.2011999995, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 179754, + "strid": "75f0a019-f9df-4b16-a199-585d923206f5", + "image_id": 207521, + "image_name": "8352.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 3109.435, + 1833.987, + 1089.1979999999999, + 514.482 + ], + "priority": 12, + "parents": [ + 179758 + ], + "children": [], + "area": 5702663.367345, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 4. Hebbian plasticity modulation with theta burst stimulation.\nWe applied 15ms stimuli in freely moving animals every 90 seconds\nduring 24 hours; after that, we sacrificed the animals and prepared\nhippocampal slices, in which we recorded the field evoked post-synaptic\npotential (fEPSPs) in the stratum radiatum of CA1 in response to\nelectrical pulses applied on the Schaffer collaterals. On the left we see\nthe recording 10 min before and 30 min after a theta burst protocol (20\nbursts of 4 pulses at 100Hz, 200ms apart); on the right is the mean\namplitude change in each group compared to baseline. Control group\nwere able to induce LTP, increasing about 40% its field amplitude\nresponse. However, mice that underwent chronic optogenetic stimulation\ndid not changed its basal response. (n control=4, CA1=2; Student's t test;\np = 0.042)" + }, + { + "id": 179762, + "strid": "26bc45e9-4f83-4aa3-9729-ab4255e4207b", + "image_id": 207521, + "image_name": "8352.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3063.232, + 2512.864, + 1301.0159999999996, + 332.43600000000015 + ], + "priority": 13, + "parents": [ + 179763 + ], + "children": [], + "area": 7697485.416448, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion: Our results suggest that chronic optogenetic\nstimulation in CA1 can modulate synaptic plasticity in this\nregion. This effect could be due to homeostatic regulation of\npostsynaptic neurons in response to increased excitability,\nalthough further experiments are needed to determine if this is\nindeed the case." + }, + { + "id": 28184, + "strid": "22fd0300-245c-4e39-957b-01deadb9afc4", + "image_id": 201610, + "image_name": "117393.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 222.07, + 206.59, + 279.42, + 287.17999999999995 + ], + "priority": -1, + "parents": [], + "children": [ + 28159, + 28167, + 28156, + 28160, + 28161, + 28158, + 28168, + 28157, + 28177 + ], + "area": 45877.4413, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 28156, + "strid": "03528697-593a-497f-9cf6-66bda8d0aead", + "image_id": 201610, + "image_name": "117393.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 881.361, + 233.81, + 2770.992, + 287.425 + ], + "priority": 1, + "parents": [ + 28184 + ], + "children": [], + "area": 206071.01541, + "iscrowd": 0, + "segmentation": [], + "text": "PAGET DISEASE OF THE NIPPLE\n\nCOMPARATIVE ANALYSIS OF DIAGNOSTIC TOOLS AND SURGICAL TREATMENT PLANNING" + }, + { + "id": 28157, + "strid": "d715e5d8-6df7-4b97-b334-72f3db174e50", + "image_id": 201610, + "image_name": "117393.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 939.385, + 627.339, + 1556.553, + 303.879 + ], + "priority": 2, + "parents": [ + 28184 + ], + "children": [], + "area": 589312.8465150001, + "iscrowd": 0, + "segmentation": [], + "text": "M. Schettino’, O.A. Catalano MD?, C. Iannace MD?\n\n1 \"La Sapienza\" Univesity, Faculty of Medicine and Odontology, Rome, Italy\n2 Fondazione IRCCS SDN, Department of Radiology, Napoli, Italy\n3 \"G. Moscati\" Hospital, Brest Unit-General Surgery Department, Avellino, Italy" + }, + { + "id": 28167, + "strid": "c0d35239-6f26-4302-b626-dc1716130f59", + "image_id": 201610, + "image_name": "117393.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 108.817, + 1329.263, + 346.818, + 2360.636 + ], + "priority": 3, + "parents": [ + 28184 + ], + "children": [], + "area": 144646.411871, + "iscrowd": 0, + "segmentation": [], + "text": "AjezT ‘ouljeay\nquUsWed|ag A1sdBing jesauUa5-}1UN WesdI1g\n\nWLIdGSOH ,ILVOISOW *5),," + }, + { + "id": 28158, + "strid": "e95cc2ac-f792-410a-bdff-08d2749d7163", + "image_id": 201610, + "image_name": "117393.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 556.4, + 995.457, + 349.97400000000005, + 41.46300000000008 + ], + "priority": 4, + "parents": [ + 28184 + ], + "children": [ + 28178, + 28179, + 28163, + 28162 + ], + "area": 553872.2748, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 28162, + "strid": "9d1db8ec-59ec-4d1b-aaf4-d5605b3dc39f", + "image_id": 201610, + "image_name": "117393.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 551.854, + 1054.41, + 1606.758, + 178.529 + ], + "priority": 5, + "parents": [ + 28158 + ], + "children": [], + "area": 581880.3761400001, + "iscrowd": 0, + "segmentation": [], + "text": "Paget disease of the breast is a rare (1-4.3% of all the breast\ncarcinomas) cancer of the nipple-areola complex often associ-\nated with an underlying in situ or invasive carcinoma." + }, + { + "id": 28178, + "strid": "b562e2a7-7bb9-4b7f-b539-1bcfb4c522ae", + "image_id": 201610, + "image_name": "117393.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 583.732, + 1318.279, + 764.088, + 600.796 + ], + "priority": 6, + "parents": [ + 28158 + ], + "children": [ + 28173 + ], + "area": 769521.637228, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 28173, + "strid": "eaf01a8b-13dc-4e6a-94be-471593ba12f9", + "image_id": 201610, + "image_name": "117393.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 617.53, + 1950.697, + 680.6569999999999, + 100.16299999999978 + ], + "priority": 7, + "parents": [ + 28178 + ], + "children": [], + "area": 1204613.91841, + "iscrowd": 0, + "segmentation": [], + "text": "A 56-year-old woman, presented with left nipple are-\nolar changes. Photograph shows skin thickening,\nredness, and scaling around the nipple areola area." + }, + { + "id": 28179, + "strid": "5f6ed3e2-847b-42c2-a657-eb47a3a14565", + "image_id": 201610, + "image_name": "117393.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1437.165, + 1328.04, + 663.8310000000001, + 592.3499999999999 + ], + "priority": 8, + "parents": [ + 28158 + ], + "children": [ + 28174 + ], + "area": 1908612.6065999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 28174, + "strid": "9cc169b1-2ecb-44c0-84c7-17c6d624965a", + "image_id": 201610, + "image_name": "117393.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1437.437, + 1969.526, + 567.6669999999999, + 29.190000000000055 + ], + "priority": 9, + "parents": [ + 28179 + ], + "children": [], + "area": 2831069.544862, + "iscrowd": 0, + "segmentation": [], + "text": "Paget disease of the nipple: Pathophysiology." + }, + { + "id": 28163, + "strid": "7204f59a-4f03-49ff-bb5e-b3d6fe3e2ec8", + "image_id": 201610, + "image_name": "117393.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 548.185, + 2084.262, + 1604.94, + 302.66600000000017 + ], + "priority": 10, + "parents": [ + 28158 + ], + "children": [], + "area": 1142561.16447, + "iscrowd": 0, + "segmentation": [], + "text": "Aim of this study: compare, in patient with proven PD, accura-\ncy of MRI and mammography, detecting underlying invasive\ncancer and ductal carcinoma in situ (DCIS), and related conse-\nquences on the improvement of the surgical treatment plan-\nning. A control group is used." + }, + { + "id": 28159, + "strid": "f946f5ca-1267-47a3-8e10-26bf7d69e66b", + "image_id": 201610, + "image_name": "117393.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 556.919, + 2453.657, + 547.62, + 41.70499999999993 + ], + "priority": 11, + "parents": [ + 28184 + ], + "children": [ + 28165, + 28175, + 28180, + 28164 + ], + "area": 1366488.202783, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 28164, + "strid": "58870c54-b54a-4d56-9696-f1fd8ebbacb1", + "image_id": 201610, + "image_name": "117393.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 555.518, + 2511.815, + 1598.716, + 237.21799999999985 + ], + "priority": 12, + "parents": [ + 28159 + ], + "children": [], + "area": 1395358.4451700002, + "iscrowd": 0, + "segmentation": [], + "text": "16 consecutive female patients (mean age 44.4; SD 0.53) with\npathological proven PD of the breast who underwent both\nmammography and breast MRI were compared with 16 female\npatients ( mean age 45; SD 0,47) affected by same" + }, + { + "id": 28180, + "strid": "3b7eb587-e5e3-4890-a5d1-500b51733449", + "image_id": 201610, + "image_name": "117393.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 603.299, + 2798.507, + 694.47, + 617.4110000000001 + ], + "priority": 13, + "parents": [ + 28159 + ], + "children": [], + "area": 1688336.474593, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 28175, + "strid": "4424a3a9-8e35-4ed7-930e-de96016537b3", + "image_id": 201610, + "image_name": "117393.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 582.334, + 3425.053, + 743.4830000000001, + 127.5 + ], + "priority": 14, + "parents": [ + 28159 + ], + "children": [], + "area": 1994524.8137019998, + "iscrowd": 0, + "segmentation": [], + "text": "Photomicrograph shows infiltration of malignant cells called\nPaget cells (arrows) among squamous cells of epidermis.\nThese malignant cells are large and show pleomorphism con-\ntaining hyperchromatic nuclei (H&E, x200)." + }, + { + "id": 28165, + "strid": "82542bbd-a4dc-42fc-a9d5-d35159e7b6c5", + "image_id": 201610, + "image_name": "117393.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1380.343, + 2752.219, + 775.7270000000001, + 727.9899999999998 + ], + "priority": 15, + "parents": [ + 28159 + ], + "children": [], + "area": 3799006.2311170003, + "iscrowd": 0, + "segmentation": [], + "text": "kind of breast cancer and sim-\nilar demographics and _ initial\nstaging but without involve-\nment of nipple-areolar area\nwho underwent both mam-\nmography and breast MRI.\nPatients were collected be-\ntween March 2004 and July\n2012. ROC regression meth-\nodology has been used to\ncompare accuracy between\nmammography and MRI." + }, + { + "id": 28160, + "strid": "8f0628e5-4d20-4a7e-87f8-1c52d7313f5c", + "image_id": 201610, + "image_name": "117393.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 557.344, + 3652.549, + 204.091, + 41.766999999999825 + ], + "priority": 16, + "parents": [ + 28184 + ], + "children": [ + 28182, + 28172, + 28170, + 28171, + 28166, + 28181 + ], + "area": 2035726.269856, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 28166, + "strid": "9b76b7ac-2349-4782-9825-ea407650567f", + "image_id": 201610, + "image_name": "117393.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 552.539, + 3713.233, + 1603.7080000000003, + 785.7430000000004 + ], + "priority": 17, + "parents": [ + 28160 + ], + "children": [], + "area": 2051706.048587, + "iscrowd": 0, + "segmentation": [], + "text": "Surgical pathology identified cancer in 16 of 16 patients (7 in-\nvasive ductal carcinoma, 8 ductal carcinoma in situ, 1 PD with-\nout underlying carcinoma).\n\nPreoperative imaging detected 14 of 15 cancers- in 1 case they\nwere completely negative.\n\nMammography detected 5 cancers, of these, accurately\ndemonstrating extent of disease in 3 of 5 patients, but failed to\nidentify 10 malignancies, either confined either extended to\nthe mammary gland, (positive predictive value 100%, negative\npredictive value 9%, sensitivity 34%, specificity 100%).\n\nWhen positive, MMG accurately predicted extent of disease in\n82% (3 of 5) of patients. Three patients proceeded to mastec-\ntomy, yielding two unifocal invasive cancer and one multicen-" + }, + { + "id": 28172, + "strid": "bfca7c6c-4fb6-4519-a5f7-ca8273d3ab25", + "image_id": 201610, + "image_name": "117393.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2207.554, + 991.529, + 1602.96, + 667.722 + ], + "priority": 18, + "parents": [ + 28160 + ], + "children": [], + "area": 2188853.810066, + "iscrowd": 0, + "segmentation": [], + "text": "tric DCIS with microinvasion, the extent of which was accu-\nrately predicted by the MRI in all patients. The two patients re-\nmaining underwent central lumpectomy.\n\nMRI detected 12 cancers, demonstrating extent of disease in 8\nof 12 patients but failed to identify 2 malignancies (PPV 100%,\nNPV 33%, sensitivity 86%, specificity 100%). Four of 12 MRI-\ndetected cancers were mammographically occult. MRI accu-\nrately predicted extent of disease in 4 of 4 patients. After neg-\native MMG, MRI accurately confirmed the need for mastectomy\nin 4 patients and accurately supported the feasibility of breast\nconserving surgery in the remaining patient." + }, + { + "id": 28181, + "strid": "9b99470e-73cf-4225-9876-d2beae8c5876", + "image_id": 201610, + "image_name": "117393.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2248.347, + 1716.235, + 612.058, + 639.0919999999999 + ], + "priority": 19, + "parents": [ + 28160 + ], + "children": [], + "area": 3858691.8135450003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 28171, + "strid": "d8af2efa-f1fd-4bc2-952f-bb926243df15", + "image_id": 201610, + "image_name": "117393.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2956.912, + 1660.639, + 853.261, + 663.8129999999999 + ], + "priority": 20, + "parents": [ + 28160 + ], + "children": [], + "area": 4910363.386767999, + "iscrowd": 0, + "segmentation": [], + "text": "In the setting of negative MRI,\nthese patients were successfully\noffered central lumpectomy.\n\nThe area under the receiver op-\nerating curve (AUC) for mam-\nmography and breast MRI is 0.31\nand 0.75, respectively. Mastecto-\nmy was performed in seven pa-\ntients, quadrantectomy in eight,\nwide local excision in one patient." + }, + { + "id": 28170, + "strid": "439e5bbc-1efb-49ed-a4bf-ba8687845dde", + "image_id": 201610, + "image_name": "117393.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2210.145, + 2449.886, + 883.3160000000003, + 657.3519999999999 + ], + "priority": 21, + "parents": [ + 28160 + ], + "children": [], + "area": 5414603.29347, + "iscrowd": 0, + "segmentation": [], + "text": "Analyzing the data of the control\ngroup: the area under the receiver\noperating curve (AUC) for mam-\nmography and breast MRI is 0.40\nand 0.55, respectively. This sug-\ngests that usefulness of MRI, in\ndetecting occult breast cancer, is\nparticularly required in the man-\nagements of patients with PD;\nmostly than in the other types of\nbreast cancer." + }, + { + "id": 28182, + "strid": "8aa3bb0f-8763-4b6f-beb4-7ca8a667dd14", + "image_id": 201610, + "image_name": "117393.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3162.507, + 2486.821, + 660.9560000000001, + 646.549 + ], + "priority": 22, + "parents": [ + 28160 + ], + "children": [], + "area": 7864588.820247, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 28161, + "strid": "8eea1f47-c180-47da-a03b-d7cafb465c27", + "image_id": 201610, + "image_name": "117393.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2212.599, + 3244.573, + 302.06100000000015, + 40.53200000000015 + ], + "priority": 23, + "parents": [ + 28184 + ], + "children": [ + 28176, + 28169, + 28183 + ], + "area": 7178938.975227, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 28169, + "strid": "45237d64-a8f7-417e-8315-0db092acaf45", + "image_id": 201610, + "image_name": "117393.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2211.335, + 3300.206, + 603.0950000000003, + 785.7910000000002 + ], + "priority": 24, + "parents": [ + 28161 + ], + "children": [], + "area": 7297861.035010001, + "iscrowd": 0, + "segmentation": [], + "text": "In our experience, MRI\nhad better accuracy\nand facilitated the se-\nlection of the appropri-\nate surgical treatment.\nUsing only mammogra-\nphy was found to un-\nderestimate the extent\nof the lesion. However\nneither negative mam-\nmography nor MRI can\nreliably exclude an un-\nderlying malignancy" + }, + { + "id": 28183, + "strid": "21696838-a7ef-4d51-b1e2-c61506c4873e", + "image_id": 201610, + "image_name": "117393.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2875.101, + 3309.626, + 924.681, + 678.3159999999998 + ], + "priority": 25, + "parents": [ + 28161 + ], + "children": [], + "area": 9515509.022226, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 28176, + "strid": "12302bbc-4c40-4f22-b75c-a8e59a8a2032", + "image_id": 201610, + "image_name": "117393.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2872.539, + 4010.862, + 928.0300000000002, + 65.93600000000015 + ], + "priority": 26, + "parents": [ + 28161 + ], + "children": [], + "area": 11521357.518618, + "iscrowd": 0, + "segmentation": [], + "text": "In the setting of negative MRI, patients were offered breast conserving\nsurgery: nipple reconstruction and nipple tattoo." + }, + { + "id": 28168, + "strid": "7d46f2b4-6eaa-46d6-8e93-983a7a90b67e", + "image_id": 201610, + "image_name": "117393.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 726.542, + 4539.581, + 3101.956, + 56.37299999999959 + ], + "priority": 27, + "parents": [ + 28184 + ], + "children": [], + "area": 3298196.2589020003, + "iscrowd": 0, + "segmentation": [], + "text": "ISCOMS — International Student Congress of (bio)Medical Sciences - 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We must identify routine areas\nof analysis and automate them. 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"2bc1a9a1-d372-4802-9a19-2f1af7d9f90a", + "image_id": 207456, + "image_name": "8193.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 520.679, + 281.863, + 2278.836, + 224.86399999999998 + ], + "priority": 2, + "parents": [ + 178257 + ], + "children": [], + "area": 146760.144977, + "iscrowd": 0, + "segmentation": [], + "text": "Pauline Heux?, Julia Matontit, Benjamin Schwarz?, Zakarya Bentatou®, Angéle Viola? and Heather C. Etchevers!\"]]\n\n1 Inserm, UMR_S910, Faculté de Médecine de la Timone, Aix Marseille University, Marseille, France * Correspondance to: heather.etchevers@univ-amu.fr\n2 Department of Biology, Friedrich-Alexander University Erlangen-Nurnberg, Erlangen, Germany\n3 Centre de Résonance Magnétique en Biologie et Médecine, UMR CNRS 7339, Aix Marseille University, Marseille, France" + }, + { + "id": 178231, + "strid": "e4ee4c12-9abc-4fd4-ba98-583de80e976a", + "image_id": 207456, + "image_name": "8193.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 564.083, + 554.86, + 359.87299999999993, + 43.49800000000005 + ], + "priority": 3, + "parents": [ + 178257 + ], + "children": [ + 178250, + 178239 + ], + "area": 312987.09338, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 178239, + "strid": "9f564729-d47d-4054-88ab-ed8d1ed6afc4", + "image_id": 207456, + "image_name": "8193.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 36.49, + 637.855, + 1084.149, + 791.3989999999999 + ], + "priority": 4, + "parents": [ + 178231 + ], + "children": [], + "area": 23275.328950000003, + "iscrowd": 0, + "segmentation": [], + "text": "The majority of giant congenital melanocytic nevi (CMN)\nharbor somatic mutations of NRAS, commonly at residue\nQ61 but also at G12. These mutations prevent Ras from\nhydrolysing GTP, rendering it constitutively active. Large\nCMN can be associated with benign tumors or early\nmelanoma, brain malformations and meningeal\n(“neurocutaneous”) melanocytosis. Current murine models\nfor CMN and their oncogenic predisposition conditionally\ninduce Ras or Raf family mutations in tyrosinase-expressing\ncells, mostly melanoblasts!. Because these mice do not\nphenocopy the circumscribed lesions observed in CMN\npatients, and CMN patterns are more extensive than\nexpected for a single mutated melanoblast, we explored a\nmodel in which Nras@!?P is induced earlier in melanoblast\nprogenitors of the premigratory neural crest." + }, + { + "id": 178250, + "strid": "5904bee6-c004-4ab7-8e83-53bfda093565", + "image_id": 207456, + "image_name": "8193.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1153.619, + 636.415, + 305.78999999999996, + 785.038 + ], + "priority": 5, + "parents": [ + 178231 + ], + "children": [], + "area": 734180.4358849999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178232, + "strid": "af3b7eca-36a1-4620-b9f4-d2e94d1ae642", + "image_id": 207456, + "image_name": "8193.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2090.58, + 555.897, + 617.239, + 42.50599999999997 + ], + "priority": 6, + "parents": [ + 178257 + ], + "children": [ + 178251, + 178240, + 178241 + ], + "area": 1162147.15026, + "iscrowd": 0, + "segmentation": [], + "text": "MATERIALS AND METHODS" + }, + { + "id": 178251, + "strid": "86c978b4-1d5e-49e0-8265-bb4c191c0683", + "image_id": 207456, + "image_name": "8193.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1505.506, + 635.478, + 858.0019999999997, + 605.9820000000001 + ], + "priority": 7, + "parents": [ + 178232 + ], + "children": [], + "area": 956715.941868, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178240, + "strid": "679413a7-cb60-4eb6-a487-3647ff22a24e", + "image_id": 207456, + "image_name": "8193.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2377.724, + 651.532, + 887.4899999999998, + 595.196 + ], + "priority": 8, + "parents": [ + 178232 + ], + "children": [], + "area": 1549163.2731680002, + "iscrowd": 0, + "segmentation": [], + "text": "Watl::Cre Gax.org stock 9107) and Nras-°*step-\nLox [floxG12D (stock 8304) mice were outbred from\ncongenic C57BL/6 to Cri:CD1(ICR), carrying\nthe Tyr‘ allele, before intermating. No differences\ncould be distinguished between homozygous and\nheterozygous activated Nras genotypes.\n\nParaplast-embedded tissue sections were\nsubjected to classical histology\n(hematoxylin/eosin). Neural crest cells were\nderived as described*. Quantitative RT-PCR was\nperformed on a Roche LightCycler® 480." + }, + { + "id": 178241, + "strid": "d0740d22-e1e8-45ac-9b16-f267d2d1f00c", + "image_id": 207456, + "image_name": "8193.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1513.21, + 1273.103, + 1758.159, + 151.54600000000005 + ], + "priority": 9, + "parents": [ + 178232 + ], + "children": [], + "area": 1926472.19063, + "iscrowd": 0, + "segmentation": [], + "text": "Mice were imaged at 11.75 T using a vertical AVANCE 500 WB wide-bore MRI system (Bruker)\nunder gaseous isoflurane. T2-weighted axial MRI images were acquired in contiguous 0.5 mm\nslices using a spin-echo sequence, segmented using in-house software and rendered with Fslview?." + }, + { + "id": 178233, + "strid": "988e5f3f-8cb7-465e-ac62-29f2fa71c9b1", + "image_id": 207456, + "image_name": "8193.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 771.832, + 1472.961, + 606.852, + 42.92699999999991 + ], + "priority": 10, + "parents": [ + 178257 + ], + "children": [ + 178244, + 178256, + 178243, + 178252, + 178254, + 178242 + ], + "area": 1136878.434552, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 178252, + "strid": "c0fba99c-ab2b-4d62-ac0f-a3198934f15d", + "image_id": 207456, + "image_name": "8193.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 23.748, + 1542.208, + 2067.232, + 590.1709999999998 + ], + "priority": 11, + "parents": [ + 178233 + ], + "children": [], + "area": 36624.355584000004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178242, + "strid": "b216288c-7024-44c8-82ae-e9457c0ec4b2", + "image_id": 207456, + "image_name": "8193.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 19.792, + 2142.062, + 2084.617, + 131.71500000000015 + ], + "priority": 12, + "parents": [ + 178233 + ], + "children": [], + "area": 42395.691104000005, + "iscrowd": 0, + "segmentation": [], + "text": "Adult mice expressing Nras©!? in all neural crest derivatives consistently bear unique skin patterns of patches with significantly\nincreased follicular density and melanocytosis. While patches are not yet visible in early juveniles, hair density is significantly\nincreased. Extrafollicular, but not dermal, melanocytosis can be present, at other epidermal annexes (arrow) or in the head/tail." + }, + { + "id": 178256, + "strid": "e1d5b7c1-5aa5-4df3-bb7d-9e75c7118d16", + "image_id": 207456, + "image_name": "8193.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 9.72, + 2304.515, + 2098.44, + 506.0 + ], + "priority": 13, + "parents": [ + 178233 + ], + "children": [], + "area": 22399.8858, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178243, + "strid": "89baa693-3740-4feb-afdf-597e124f27e6", + "image_id": 207456, + "image_name": "8193.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 19.007, + 2835.168, + 2086.829, + 130.35500000000002 + ], + "priority": 14, + "parents": [ + 178233 + ], + "children": [], + "area": 53888.03817600001, + "iscrowd": 0, + "segmentation": [], + "text": "Wntl::Cre; NrasS!?D (n=149) die significantly younger than their littermates of all other genotypes (n=314). Survivors and\nautopsied mice all show regular, regional melanocytosis of the pia mater. Despite heavy valvular and other cardiac melanocytosis, no\nstructural cardiovascular anomalies were found. No spontaneous melanomas were observed in brain, spine, lung, liver or skin." + }, + { + "id": 178244, + "strid": "0df33ac9-5728-41ec-8bec-2faa7a9a8c38", + "image_id": 207456, + "image_name": "8193.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 17.483, + 2996.469, + 1502.693, + 84.83899999999994 + ], + "priority": 15, + "parents": [ + 178233 + ], + "children": [], + "area": 52387.267527, + "iscrowd": 0, + "segmentation": [], + "text": "Mutant mice all showed gingival (arrows) and splenic melanocytosis. Adrenal glands (not\nshown), sexual organs and certain lymph nodes (LN) were less frequently affected." + }, + { + "id": 178254, + "strid": "187bd20c-9ad0-432d-9205-703f6ad07195", + "image_id": 207456, + "image_name": "8193.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 10.509, + 3096.405, + 1508.894, + 690.2170000000001 + ], + "priority": 16, + "parents": [ + 178233 + ], + "children": [], + "area": 32540.120145000004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178234, + "strid": "b29e3cbe-d573-49cb-8a9c-0d7ea55d6926", + "image_id": 207456, + "image_name": "8193.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2627.843, + 1473.42, + 192.86499999999978, + 49.71900000000005 + ], + "priority": 17, + "parents": [ + 178257 + ], + "children": [ + 178253, + 178246 + ], + "area": 3871916.43306, + "iscrowd": 0, + "segmentation": [], + "text": "qRT-PCR" + }, + { + "id": 178253, + "strid": "9afbc95d-5bcf-489c-81ea-4e004a947a2e", + "image_id": 207456, + "image_name": "8193.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2154.03, + 1551.913, + 1122.9320000000002, + 1196.1889999999999 + ], + "priority": 18, + "parents": [ + 178234 + ], + "children": [], + "area": 3342867.15939, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178246, + "strid": "1b7786c9-b3a8-4780-9986-9f24f0043ec9", + "image_id": 207456, + "image_name": "8193.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2161.645, + 2756.548, + 1123.212, + 260.77 + ], + "priority": 19, + "parents": [ + 178234 + ], + "children": [], + "area": 5958678.201459999, + "iscrowd": 0, + "segmentation": [], + "text": "Primary neural crest cell cultures were derived from individual\nWnt1::Cre;Nras*t/* or Nras@!2?’/+ E9.5 embryos. After transfer for 10\ndays to differentiation medium, Cxcr4, Tgfbr1, Hes! and Soxl0\nexpression was increased in both cell types. However, in\nWnt1::Cre;NrasS!2> cells only, Notch2 was downregulated while\nWnt10b and cKit were upregulated." + }, + { + "id": 178236, + "strid": "4d1cea4c-744e-4a09-a27f-973a6d47bb59", + "image_id": 207456, + "image_name": "8193.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2037.085, + 3055.409, + 764.9809999999998, + 45.24499999999989 + ], + "priority": 20, + "parents": [ + 178257 + ], + "children": [ + 178247, + 178255 + ], + "area": 6224127.842765001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 178255, + "strid": "eb90f9de-fe1a-491b-bfcb-dff23857f365", + "image_id": 207456, + "image_name": "8193.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1540.323, + 3140.665, + 1217.5710000000001, + 761.5729999999999 + ], + "priority": 21, + "parents": [ + 178236 + ], + "children": [], + "area": 4837638.534795, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 178247, + "strid": "bea7f5b7-f79b-462c-82b7-9707ee044395", + "image_id": 207456, + "image_name": "8193.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2753.556, + 3146.269, + 537.4279999999999, + 749.2150000000001 + ], + "priority": 22, + "parents": [ + 178236 + ], + "children": [], + "area": 8663427.882563999, + "iscrowd": 0, + "segmentation": [], + "text": "Volumes of major white matter\n(WM) tracts and ventricles in live\nWntl1::Cre;Nras*’+ versus\nWnt1::Cre;Nras¢!2b/+ adult\nmice, expressed as percentage of\ntotal brain volume. Mutant and\ncontrol groups had no significant\ndifferences in fascicular or\nventricular volumes (Mann-\nWhitney test). “Other WM tracts”\n= summed volumes of the\ninternal capsule, fimbria, stria\nterminalis, cerebral peduncle,\nmedial forebrain bundle and\nnigrostriatal bundle. Additional\nstructures are currently under\ninvestigation." + }, + { + "id": 178235, + "strid": "a466a631-a719-474a-b534-50151fb1b437", + "image_id": 207456, + "image_name": "8193.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 599.216, + 3809.941, + 327.078, + 43.05099999999993 + ], + "priority": 23, + "parents": [ + 178257 + ], + "children": [ + 178245 + ], + "area": 2282977.6062559998, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 178245, + "strid": "bf27e831-6678-4a36-97ff-41819bb5f36e", + "image_id": 207456, + "image_name": "8193.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 13.685, + 3885.742, + 1499.798, + 418.6700000000001 + ], + "priority": 24, + "parents": [ + 178235 + ], + "children": [], + "area": 53176.379270000005, + "iscrowd": 0, + "segmentation": [], + "text": "Mice expressing constitutively active NrasS!? in neural crest cells develop black\nskin patches under their fur due to follicular melanocytosis and densification. As a\npopulation, these mice die younger than littermates with normal Nras activity. They\npresent extracutaneous melanocytosis in diverse tissues, of which a subset of sites\nare affected in humans bearing NRAS-mutated CMN. We are currently exploring\nthe differential molecular response of primary neural crest cell cultures with or\nwithout Nras%!?> to conditions favoring melanocyte development, as well as\nneuropathology using diffusion tensor imaging." + }, + { + "id": 178237, + "strid": "c6d4468c-a2ea-40bc-8e01-0ed3e185d4fa", + "image_id": 207456, + "image_name": "8193.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1717.553, + 3932.959, + 523.3060000000003, + 46.28800000000001 + ], + "priority": 25, + "parents": [ + 178257 + ], + "children": [ + 178248 + ], + "area": 6755065.5293270005, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 178248, + "strid": "362ea29d-db49-43b5-8c42-f20b80b4dc36", + "image_id": 207456, + "image_name": "8193.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1549.86, + 4010.577, + 859.999, + 162.76100000000042 + ], + "priority": 26, + "parents": [ + 178237 + ], + "children": [], + "area": 6215832.86922, + "iscrowd": 0, + "segmentation": [], + "text": "Many thanks to Stéphane Zaffran, Lionel Larue, Véronique Delmas, Richard\nMarais, Fatoumata Djitte, Gaélle Odelin, Nicolas Levy and our non-profit,\nnon-governmental funders: Nzvus 2000 France-Europe, Association du\nNevus Géant Congénital, Asociacién Espafiola de Nevus Gigante, Nevus\nOutreach, and the Blackswan Foundation’s RE(ACT) Community." + }, + { + "id": 178238, + "strid": "d2bd573f-6844-495c-b10e-df4f8c3b01de", + "image_id": 207456, + "image_name": "8193.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2721.994, + 3934.835, + 287.7669999999998, + 44.271999999999935 + ], + "priority": 27, + "parents": [ + 178257 + ], + "children": [ + 178249 + ], + "area": 10710597.260990001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 178249, + "strid": "ebb97698-0590-4f52-ae94-0c93a2379e4a", + "image_id": 207456, + "image_name": "8193.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2441.748, + 4007.294, + 832.1489999999999, + 312.8019999999997 + ], + "priority": 28, + "parents": [ + 178238 + ], + "children": [], + "area": 9784802.109912, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 4959, + "strid": "5dbf0513-53c8-422b-ab59-99b6c3fc8bd8", + "image_id": 200703, + "image_name": "10639.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 350.95, + 17.85, + 244.49000000000007, + 236.34 + ], + "priority": -1, + "parents": [], + "children": [ + 4942, + 4939, + 4935, + 4955, + 4957, + 4936, + 4937, + 4945, + 4943 + ], + "area": 6264.4575, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 4935, + "strid": "87041bca-acde-4dbf-b1e1-e414c858ca18", + "image_id": 200703, + "image_name": "10639.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 647.116, + 87.958, + 2139.39, + 354.294 + ], + "priority": 1, + "parents": [ + 4959 + ], + "children": [], + "area": 56919.029127999995, + "iscrowd": 0, + "segmentation": [], + "text": "Inequities in access to maternal and child\nhealthcare and poor outcomes in rural Sierra\nLeone: findings of mixed methods study" + }, + { + "id": 4936, + "strid": "8b762121-6693-43ff-85ee-0b4b4b271cbb", + "image_id": 200703, + "image_name": "10639.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 89.407, + 554.163, + 3194.517, + 266.547 + ], + "priority": 2, + "parents": [ + 4959 + ], + "children": [], + "area": 49546.051341, + "iscrowd": 0, + "segmentation": [], + "text": "J Elston (1), K Danis (2), N Gray (3), K West (4) B Stringer (4) K Lokuge (5), B Back (6) A.S Jimmisa (7) A Biankoe (7), MO Sanko (7),\nA | Carrion Martin (8), D S Kazungu (8) | Ait-Bouziad (4) P Masters (4) S Sang (8), R J Southgate (4), G Caleo (4)\n\n1. Field Epidemiology Training Programme (FETP), Public Health England, UK; 2.European Programme for Interventional Epidemiology Training (EPIET), European Centre for Disease Prevention and Control (ECDC),\nStockholm, Sweden; 3.Médecins Sans Frontiéres (MSF), London, UK; 4. MSF, London, UK; 5. National Centre for Epidemiology and Population Health, Research School of Population Health, Australian National\nUniversity, Canberra, Australia; 6. The Royal Free Hospital, London; 7.District Health Management Team, Ministry of Health and Sanitation, Tonkolili, Sierra Leone; 8.MSF, Amsterdam, The Netherlands" + }, + { + "id": 4937, + "strid": "704323bf-b20a-444b-9dc4-392e6d8dcc09", + "image_id": 200703, + "image_name": "10639.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 72.029, + 917.894, + 318.392, + 55.807000000000016 + ], + "priority": 3, + "parents": [ + 4959 + ], + "children": [ + 4938 + ], + "area": 66114.986926, + "iscrowd": 0, + "segmentation": [], + "text": "Background" + }, + { + "id": 4938, + "strid": "85d23c5b-57d1-47c3-8146-24819c9d7e29", + "image_id": 200703, + "image_name": "10639.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 68.409, + 983.178, + 1314.063, + 640.6550000000001 + ], + "priority": 4, + "parents": [ + 4937 + ], + "children": [], + "area": 67258.22380200001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 4939, + "strid": 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"10639.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1631.851, + 2832.352, + 1419.4630000000002, + 50.070000000000164 + ], + "priority": 20, + "parents": [ + 4954 + ], + "children": [], + "area": 4621976.443552, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3: Summary of barriers from survey and in depth-interviews" + }, + { + "id": 4955, + "strid": "e5f17f71-595a-48c5-850c-b07b78f20b0e", + "image_id": 200703, + "image_name": "10639.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1518.767, + 4023.438, + 904.8150000000003, + 50.153999999999996 + ], + "priority": 21, + "parents": [ + 4959 + ], + "children": [ + 4956 + ], + "area": 6110664.860946001, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion and recommendations" + }, + { + "id": 4956, + "strid": "8c70ae9c-2022-4003-a209-99469e7517cf", + "image_id": 200703, + "image_name": "10639.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1515.387, + 4082.374, + 1778.8820000000003, + 368.3289999999997 + ], + "priority": 22, + "parents": [ + 4955 + ], + "children": [], + "area": 6186376.488737999, + "iscrowd": 0, + "segmentation": [], + "text": "Health outcomes are poor in both areas and under5 mortality rate rurally is close to the\nemergency threshold. A high proportion of women give birth at home without assistance.\nFindings indicate inequity in access to maternal and child healthcare. Focus must be given\nto improving healthcare delivered at primary healthcare level in rural Sierra Leone.\nHealthcare has to be accessible, free of charge and of good quality. To further increase\naccessibility community health worker networks need to be strengthened, along with\nmaternal death surveillance" + }, + { + "id": 4957, + "strid": "79b4c3b9-21a5-4f33-bb13-da0585bb07f4", + "image_id": 200703, + "image_name": "10639.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1516.904, + 4588.237, + 519.4670000000001, + 57.1840000000002 + ], + "priority": 23, + "parents": [ + 4959 + ], + "children": [ + 4958 + ], + "area": 6959915.058248, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements" + }, + { + "id": 4958, + "strid": "2b840ded-0d14-4841-b6af-89feef22fa8f", + "image_id": 200703, + "image_name": "10639.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1517.067, + 4653.417, + 1759.7960000000003, + 99.83399999999983 + ], + "priority": 24, + "parents": [ + 4957 + ], + "children": [], + "area": 7059545.367939001, + "iscrowd": 0, + "segmentation": [], + "text": "We would like to thank the our study teams and colleagues in the project for their support,\nand, most importantly, the communities of Tonkolili for participating in this study." + }, + { + "id": 65709, + "strid": "7aebbd62-f9ac-4374-a75c-c4052128d83a", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 4110.7, + 473.54, + 325.9899999999998, + 268.94 + ], + "priority": -1, + "parents": [], + "children": [ + 65677, + 65681, + 65674, + 65675, + 65676, + 65679, + 65678, + 65680 + ], + "area": 1946580.878, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 65674, + "strid": "c4af0c98-1039-4346-82d6-5e8c378c270c", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 4468.961, + 177.554, + 2984.327, + 186.273 + ], + "priority": 1, + "parents": [ + 65709 + ], + "children": [], + "area": 793481.901394, + "iscrowd": 0, + "segmentation": [], + "text": "Smooth pursuit of flicker-defined motion" + }, + { + "id": 65675, + "strid": "a376cc8c-7aa9-422e-b67e-1c257dfb169f", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 4756.057, + 438.173, + 2509.486, + 199.78999999999996 + ], + "priority": 2, + "parents": [ + 65709 + ], + "children": [], + "area": 2083975.7638609998, + "iscrowd": 0, + "segmentation": [], + "text": "JeffreyyB. Mulligan Scott. B.Stevenson\n\nNASA Ames Research Center University of Houston College of Optometry" + }, + { + "id": 65676, + "strid": "dbf79e6c-dac7-4621-90c9-6241dfc8ccc4", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1125.11, + 153.208, + 982.3199999999999, + 110.405 + ], + "priority": 3, + "parents": [ + 65709 + ], + "children": [ + 65687, + 65682, + 65704, + 65683, + 65686, + 65688, + 65684, + 65706, + 65685 + ], + "area": 172375.85288, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 65684, + "strid": "579bf5f0-2fc0-443c-97a3-a2ee001e9520", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 293.227, + 383.988, + 901.668, + 542.4299999999998 + ], + "priority": 4, + "parents": [ + 65676 + ], + "children": [], + "area": 112595.649276, + "iscrowd": 0, + "segmentation": [], + "text": "Delayed Visual Feedback\n\n{JOURNAL OF NEUROPHYSOLOGY\nVol. 67, No 3, March I¥92. Printed in U.S.A,\n\nEffect of Changing Reedback‘Delay on Spontaneous Oscillations\nin Smooth Pursuit EyeMovements of Monkeys\n\nD. GOLDREICH, R.d™KRAUZLIS, AND S. G. LISBERGER\nDepartment of Physidlogy, W.M. Keck Foundation Center for Integrative\nNeuroscience, andgNeurdsciende Graduate Program, University of California, San Francisco, California 94143" + }, + { + "id": 65706, + "strid": "79e5438f-889d-474d-ac57-21bc641c94a7", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 274.715, + 984.058, + 929.117, + 509.558 + ], + "priority": 5, + "parents": [ + 65676 + ], + "children": [], + "area": 270335.49347, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 65683, + "strid": "9e7b8cd0-31dc-4105-af07-8604748a9781", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 261.181, + 1808.144, + 962.0719999999999, + 2236.611 + ], + "priority": 6, + "parents": [ + 65676 + ], + "children": [], + "area": 472252.858064, + "iscrowd": 0, + "segmentation": [], + "text": "Theory\n\ne(t) eye*position (EP)\n\np(t) target position\n\né(f) eye velocity (EV)\n\npt) target velocity\n\né(t) eye acceleration (EA)\n\np(t) target acceleration\n\np(t)=k stationary target\np(t) =e(t) ideal stabilization\np(t)=e(t-e) lab stabilization\np(t)=e(t)+d(t) open-loop\n\np(t)=e(t)—e(t—6,) transient stabilization\n\np(t)—e(t) retinal pOsitton error (RPE)\np(t)-ée(t) retinal\\yelocity error (RVE)\np(t)-é(t) retinal acceleration error (RAE)\nE(t) =k p@ B= ect) RPE drives EA\n\n(t= Ihe = Sj si | RVE drives EA\n\né(f) = kL Be —6,)-€(t- 6, | RAE drives EA" + }, + { + "id": 65682, + "strid": "4ccdd894-671a-4527-8d9d-bf950838184e", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1815.297, + 381.482, + 953.8490000000002, + 1517.113 + ], + "priority": 7, + "parents": [ + 65676 + ], + "children": [], + "area": 692503.130154, + "iscrowd": 0, + "segmentation": [], + "text": "Predictions\n\np(t) =e(t)—e(t— 65) (transient stabilization\n\n(1) =k] p@Sg) 2eO-a)| RPE drives EA\n\ne(t)= hl ete- 5) -e(t 4 = &)-e(t-6)|\n@(t ) =—k,e(t — 6, — 55)\né(t) =—k, e(t— 6)\ne(t) =e” trial solution\nsatisfied if k, = ow anda=6,\nwhere 4 = Pm\no\n\nA=6 RPE drives EA\nA=46 RVE drives EA\n\nAz 26 RAE drives EA" + }, + { + "id": 65686, + "strid": "bc500601-908e-46f0-b439-8da6307113e6", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1477.238, + 2302.521, + 1569.0509999999997, + 809.6979999999999 + ], + "priority": 8, + "parents": [ + 65676 + ], + "children": [], + "area": 3401371.5169980004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 65685, + "strid": "9e6c8cd6-c928-4318-9774-b85c502980ff", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2150.587, + 3219.199, + 264.30499999999984, + 69.22299999999996 + ], + "priority": 9, + "parents": [ + 65676 + ], + "children": [], + "area": 6923167.519813, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 65687, + "strid": "c03e9fb4-49ff-45a4-9cfc-d656761c4ed5", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1612.55, + 3372.227, + 686.7349999999999, + 479.058 + ], + "priority": 10, + "parents": [ + 65676 + ], + "children": [ + 65705 + ], + "area": 5437884.6488499995, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 65705, + "strid": "c34c41f3-bd6e-4c26-8d9c-ed1e1a6a5688", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1567.084, + 3854.277, + 599.4130000000002, + 94.44799999999987 + ], + "priority": 11, + "parents": [ + 65687 + ], + "children": [], + "area": 6039975.818268, + "iscrowd": 0, + "segmentation": [], + "text": "iG. 4. Relationship between of us oscillation and the total feedback delay. Each graph plots the\nduration ofthe 1st half period of tions as \\n ofthe sum of the natural latency for pursuit and the artiiral\ndelay added by the computer. A ¢ 3} monkey Open symbols represent data obtained with a big, bright target and\nshort natural delays, and fi data band wih ial i get and anges maura he nes\ndescribe the reationshis lat@ijgauals 2 or 4 times total delay. As described in the APPENDIX. these lines\n\nbetween the period of oscillation and the total clay, The spoeds of target\n\nrepresent the theoretical of i\nshh meee\n\nmotion wered0°/s in" + }, + { + "id": 65704, + "strid": "daf6dbe4-b5df-42a7-a666-554c75aaad23", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1658.557, + 3976.242, + 441.00800000000004, + 21.567000000000007 + ], + "priority": 12, + "parents": [ + 65676 + ], + "children": [], + "area": 6594824.002794, + "iscrowd": 0, + "segmentation": [], + "text": "Figure from Goldreich, Krauzlis & Lisberger (1992)." + }, + { + "id": 65688, + "strid": "8d9339af-dbf0-42bc-bf50-07b085ab9add", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2415.227, + 3374.775, + 555.5030000000002, + 558.0520000000001 + ], + "priority": 13, + "parents": [ + 65676 + ], + "children": [], + "area": 8150847.698925, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 65679, + "strid": "7db44014-a76e-4630-aa23-e3801ff24654", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4905.592, + 847.319, + 1208.679, + 112.09500000000003 + ], + "priority": 14, + "parents": [ + 65709 + ], + "children": [ + 65708, + 65691, + 65701, + 65702, + 65696 + ], + "area": 4156601.3078479995, + "iscrowd": 0, + "segmentation": [], + "text": "First-order stimuli" + }, + { + "id": 65696, + "strid": "0df59bc0-84fc-4529-af0e-c5cedb5f8c8d", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3324.625, + 951.2, + 1232.5609999999997, + 927.2650000000001 + ], + "priority": 15, + "parents": [ + 65679 + ], + "children": [], + "area": 3162383.3000000003, + "iscrowd": 0, + "segmentation": [], + "text": "Motivation:\n\nPrevious work suggests pursuit\nresponses combine signals from\nvoluntary and reflexive pathways with\ndAifferenE properties, which réspond to\ndifferent stimuli, The reflexive\nsystem appears to respond only to\nfirst-order (Luminance-defined)\nmotion; here we investigate whether\nthe voluntary system has a different\nweighting of position and velocity\ninputs," + }, + { + "id": 65691, + "strid": "9995904d-5025-45c8-9c08-25f5272e4121", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 4676.893, + 1093.465, + 721.6810000000005, + 843.1009999999999 + ], + "priority": 16, + "parents": [ + 65679 + ], + "children": [], + "area": 5114018.804245, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 65702, + "strid": "b1a11b17-6468-499f-a1d3-d133a941652b", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4782.89, + 2292.992, + 449.4520000000002, + 118.97299999999996 + ], + "priority": 17, + "parents": [ + 65679 + ], + "children": [], + "area": 10967128.506880002, + "iscrowd": 0, + "segmentation": [], + "text": "“black”" + }, + { + "id": 65708, + "strid": "dfa0ccb6-b468-439f-afe4-aa08e1dfbc17", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 5597.275, + 1102.502, + 720.8299999999999, + 855.385 + ], + "priority": 18, + "parents": [ + 65679 + ], + "children": [], + "area": 6171006.882049999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 65701, + "strid": "439944ec-a88d-470b-9726-964830ba4bcd", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 5733.019, + 2286.382, + 432.9279999999999, + 143.75900000000001 + ], + "priority": 19, + "parents": [ + 65679 + ], + "children": [], + "area": 13107871.447258001, + "iscrowd": 0, + "segmentation": [], + "text": "“rig EA”" + }, + { + "id": 65680, + "strid": "cd43aa66-c180-4c67-9f24-be9fb5c7a384", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4860.22, + 2612.298, + 1282.2489999999998, + 118.94200000000001 + ], + "priority": 20, + "parents": [ + 65709 + ], + "children": [ + 65692, + 65693, + 65707, + 65700, + 65698, + 65694, + 65699, + 65695, + 65697 + ], + "area": 12696342.98556, + "iscrowd": 0, + "segmentation": [], + "text": "Third-order stimuli" + }, + { + "id": 65697, + "strid": "43aa84d6-98b1-4453-8c74-db06a0e2303b", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3352.359, + 2286.159, + 991.6600000000003, + 635.308 + ], + "priority": 21, + "parents": [ + 65680 + ], + "children": [], + "area": 7664025.699081, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 65695, + "strid": "f5138c6d-1e41-4b73-8962-c955a97db81a", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3318.936, + 3035.177, + 1109.3049999999998, + 144.11500000000024 + ], + "priority": 22, + "parents": [ + 65680 + ], + "children": [], + "area": 10073558.211672, + "iscrowd": 0, + "segmentation": [], + "text": "Figure from Mulligan, Skevenson.g Cormacie (2013),\nshowing proposed architectural-model of pursuit control\nsystem, with portions relevent to this poster highlighted." + }, + { + "id": 65694, + "strid": "908b866b-7ce6-4648-ae87-4ca3d1000de5", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3317.348, + 3284.367, + 1161.286, + 357.087 + ], + "priority": 23, + "parents": [ + 65680 + ], + "children": [], + "area": 10895388.298716001, + "iscrowd": 0, + "segmentation": [], + "text": "BIG QUESTION:\n\nCanrwe demonstrate a position-\ndriven \\pursuit response for certain\nclasses of stimuli" + }, + { + "id": 65693, + "strid": "35061b4f-008f-4eac-96ed-e610ba30b6f9", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3314.784, + 3769.954, + 1138.15, + 301.0590000000002 + ], + "priority": 24, + "parents": [ + 65680 + ], + "children": [], + "area": 12496583.199936, + "iscrowd": 0, + "segmentation": [], + "text": "Approach:\n\nclaged Visual Feedbacke\n\n(see ackground panel at Left)" + }, + { + "id": 65692, + "strid": "514f510d-19c2-4432-92e8-2acb322e7886", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 4698.921, + 2837.405, + 713.4439999999995, + 849.1959999999999 + ], + "priority": 25, + "parents": [ + 65680 + ], + "children": [], + "area": 13332741.940005003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 65700, + "strid": "1e3ceda7-600d-4660-968c-3756f9608729", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4784.484, + 3729.677, + 584.9089999999997, + 116.98199999999997 + ], + "priority": 26, + "parents": [ + 65680 + ], + "children": [], + "area": 17844579.931668002, + "iscrowd": 0, + "segmentation": [], + "text": "“Ewwinlele”" + }, + { + "id": 65707, + "strid": "eafe767d-4eb3-4367-b012-140fd41955f7", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 5580.682, + 2849.226, + 720.2020000000002, + 846.3389999999999 + ], + "priority": 27, + "parents": [ + 65680 + ], + "children": [], + "area": 15900624.252132, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 65699, + "strid": "cd45112b-5054-403f-8f2d-0d384c544111", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 5717.618, + 3732.397, + 465.20700000000033, + 108.82000000000016 + ], + "priority": 28, + "parents": [ + 65680 + ], + "children": [], + "area": 21340420.270346, + "iscrowd": 0, + "segmentation": [], + "text": "“okobkic”" + }, + { + "id": 65698, + "strid": "89acb9e6-3e43-4ecf-8e82-610e949ac649", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4711.03, + 3914.671, + 1539.808, + 214.91999999999962 + ], + "priority": 29, + "parents": [ + 65680 + ], + "children": [], + "area": 18442132.52113, + "iscrowd": 0, + "segmentation": [], + "text": "Space-time plots showing time (Lop-to=pottom),\nand one spatial dimension for the four classes\nof stimuli studied," + }, + { + "id": 65678, + "strid": "431236d7-847b-4155-bf9d-d0db6020f62f", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 6784.406, + 803.456, + 372.83899999999994, + 104.78499999999997 + ], + "priority": 30, + "parents": [ + 65709 + ], + "children": [ + 65690 + ], + "area": 5450971.7071360005, + "iscrowd": 0, + "segmentation": [], + "text": "Trials" + }, + { + "id": 65690, + "strid": "dc88c127-b2e4-41a1-9e52-4552eefe5b53", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 6553.081, + 1136.355, + 832.299, + 2997.89 + ], + "priority": 31, + "parents": [ + 65678 + ], + "children": [], + "area": 7446626.359755, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 65677, + "strid": "06065cbd-cb1e-4ec0-bb67-a0abd9fbd92d", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 7917.543, + 796.145, + 450.8179999999993, + 116.96900000000005 + ], + "priority": 32, + "parents": [ + 65709 + ], + "children": [ + 65689 + ], + "area": 6303512.2717349995, + "iscrowd": 0, + "segmentation": [], + "text": "Resulks" + }, + { + "id": 65689, + "strid": "58c16bfc-3f4e-470f-84c4-82a1304c26d4", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 7636.166, + 985.431, + 1097.1330000000007, + 2204.884 + ], + "priority": 33, + "parents": [ + 65677 + ], + "children": [], + "area": 7524914.697546001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 65681, + "strid": "fe8ce4a2-105e-4809-8779-5be1e9f5d102", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 7514.65, + 3250.521, + 733.9570000000003, + 113.13999999999987 + ], + "priority": 34, + "parents": [ + 65709 + ], + "children": [ + 65703 + ], + "area": 24426527.63265, + "iscrowd": 0, + "segmentation": [], + "text": "Conclasion" + }, + { + "id": 65703, + "strid": "6974da5d-2270-4ea5-b2f9-9c53f63375c6", + "image_id": 203081, + "image_name": "119693.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 7620.397, + 3391.193, + 1132.4440000000004, + 356.2930000000001 + ], + "priority": 35, + "parents": [ + 65681 + ], + "children": [], + "area": 25842236.963621, + "iscrowd": 0, + "segmentation": [], + "text": "Can we aemonstrate a position\nDriven pursuit response for certain\nClasses of stimuli?\n\nTODAY'S ANSWER: Nok yeu" + }, + { + "id": 75740, + "strid": "1dfb6dae-caf2-4506-a46e-da687f6d12c1", + "image_id": 203452, + "image_name": "120263.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 74.35, + 447.45, + 229.15, + 236.54000000000002 + ], + "priority": -1, + "parents": [], + "children": [ + 75716, + 75720, + 75721, + 75723, + 75717, + 75718, + 75715, + 75714, + 75722, + 75712, + 75719, + 75713 + ], + "area": 33267.907499999994, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 75712, + "strid": "7a84f2bc-9502-4b0b-9225-babe1b82b897", + "image_id": 203452, + "image_name": "120263.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 644.537, + 104.661, + 1733.2169999999999, + 123.493 + ], + "priority": 1, + "parents": [ + 75740 + ], + "children": [], + "area": 67457.88695700001, + "iscrowd": 0, + "segmentation": [], + "text": "The LIMO-EEG Toolbox:\nextending the statistical analysis of EEG data to the spectral domain" + }, + { + "id": 75713, + "strid": "b282a48a-c404-455a-94b4-267bd2ee2cce", + "image_id": 203452, + "image_name": "120263.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 758.889, + 305.363, + 1547.65, + 209.57599999999996 + ], + "priority": 2, + "parents": [ + 75740 + ], + "children": [], + "area": 231736.621707, + "iscrowd": 0, + "segmentation": [], + "text": "A. Stewart' G.A. Rousselet? & C.R. Pernet '\n\n\" Brain Research Imaging Centre, University of Edinburgh, Edinburgh, UK\n? Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, UK" + }, + { + "id": 75723, + "strid": "9d1e9d72-d092-40c9-be84-f723baed2453", + "image_id": 203452, + "image_name": "120263.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 468.745, + 591.313, + 2006.3070000000002, + 162.45100000000002 + ], + "priority": 3, + "parents": [ + 75740 + ], + "children": [], + "area": 277175.012185, + "iscrowd": 0, + "segmentation": [], + "text": "A stable version of the LIMO EEG toolbox is available within EEGLAB, through\n‘File > Manage EEGLAB Extensions’, and also at https://gforge.dcn.ed}ac.uk/gf/project/limo_eeg\n\nThe latest developer version, as presented here, can be downloaded and extended at github.com/LIMO-EEG-Toolbox" + }, + { + "id": 75714, + "strid": "a9ed1b2c-d863-4871-9341-ab64ce3de73d", + "image_id": 203452, + "image_name": "120263.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 73.153, + 813.658, + 251.47699999999998, + 36.249000000000024 + ], + "priority": 4, + "parents": [ + 75740 + ], + "children": [ + 75724 + ], + "area": 59521.523674000004, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 75724, + "strid": "d2b56fbf-e281-4d0d-acef-fb3836978476", + "image_id": 203452, + "image_name": "120263.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 82.251, + 913.217, + 1317.275, + 349.73300000000006 + ], + "priority": 5, + "parents": [ + 75714 + ], + "children": [], + "area": 75113.011467, + "iscrowd": 0, + "segmentation": [], + "text": "LIMO EEG is an open source Matlab toolbox) EEGLAB compatible, which provides a suite\nof tools based around statistical Llnear MOdelling and robust estimators of EEG data [1].\nThe main idea behind the toolbox‘is to’analyse the entire information-space, in time or\nfrequency domain.\n\nIn the 1st version of the toolbox, ERP could be analysed at all electrodes and time points.\nHere, we report the extension of these tools into the spectral domain: (i) for powér\nspectra, showing what'frequencies are represented across trials, (ii) for Event-Related\nSpectral Perturbations (ERSP), showing the power spectra in time and frequency spaces" + }, + { + "id": 75715, + "strid": "f72403dd-8ddf-4fd9-9460-d6d3ee9015d1", + "image_id": 203452, + "image_name": "120263.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 78.071, + 1306.417, + 570.413, + 46.16300000000001 + ], + "priority": 6, + "parents": [ + 75740 + ], + "children": [ + 75739 + ], + "area": 101993.281607, + "iscrowd": 0, + "segmentation": [], + "text": "Key Features of the toolbox" + }, + { + "id": 75739, + "strid": "b268d41d-af49-4c03-9a10-cf94e0ed3dcb", + "image_id": 203452, + "image_name": "120263.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 75.799, + 1406.696, + 1220.885, + 369.30500000000006 + ], + "priority": 7, + "parents": [ + 75715 + ], + "children": [], + "area": 106626.150104, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 75716, + "strid": "827d482c-67e7-42a2-8715-b8168c1e72e5", + "image_id": 203452, + "image_name": "120263.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 74.19, + 1821.613, + 583.249, + 46.32899999999995 + ], + "priority": 8, + "parents": [ + 75740 + ], + "children": [ + 75734, + 75725 + ], + "area": 135145.46847, + "iscrowd": 0, + "segmentation": [], + "text": "Illustration and data analysis" + }, + { + "id": 75725, + "strid": "e6e1d86a-12d1-496c-8b31-de15ab3de34e", + "image_id": 203452, + "image_name": "120263.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 75.26, + 1907.968, + 1318.743, + 269.82399999999984 + ], + "priority": 9, + "parents": [ + 75716 + ], + "children": [], + "area": 143593.67168000003, + "iscrowd": 0, + "segmentation": [], + "text": "LIMO EEG data set was analysed in/the time and frequency domains. Briefly, 14 subjects\nranging from 21 to 68 years“of age performed a 2 AFC task, choosing between 2 faces\npresented at different noise» levels ([3], [4], Figure 1). Subjects performed over 1000\ntrials and 128 channels\\EEG data recorded. The statistical analysis consisted in modelling,\nper subject, the EEGyrésponse with one categorical variable (face A or face B) and one\ncontinuous variable (noise level). At the group level, a one-sample t-test and a regression\nanalysis were_computed to test the effect of noise level across subjects." + }, + { + "id": 75734, + "strid": "0114c391-520c-4bf0-a40b-29901b2102be", + "image_id": 203452, + "image_name": "120263.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 132.917, + 2211.023, + 1156.063, + 708.9780000000001 + ], + "priority": 10, + "parents": [ + 75716 + ], + "children": [ + 75733 + ], + "area": 293882.54409100005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 75733, + "strid": "8034a379-5261-4b5d-a19e-540ad5eefc83", + "image_id": 203452, + "image_name": "120263.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 85.778, + 2975.184, + 1259.498, + 152.84000000000015 + ], + "priority": 11, + "parents": [ + 75734 + ], + "children": [], + "area": 255205.33315200004, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. Experiment used for the LIMO EEG data set. Subjects discriminated between\n2 faces with(various levels of noise. The grand mean ERP show a strong modulation of\nthe N170/P200. Analyses were carried out by modelling, for each/subject, the EEG\nresponse ‘as a function of stimulus type and noise level across stimuliz" + }, + { + "id": 75717, + "strid": "a8d4d70b-6772-4875-a9f5-37bc80ead48d", + "image_id": 203452, + "image_name": "120263.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 80.588, + 3177.856, + 267.10800000000006, + 46.860999999999876 + ], + "priority": 12, + "parents": [ + 75740 + ], + "children": [ + 75737, + 75726 + ], + "area": 256097.059328, + "iscrowd": 0, + "segmentation": [], + "text": "ERP Analyses" + }, + { + "id": 75726, + "strid": "8c75bbc3-f60c-4da6-a71b-18ea1d2c6738", + "image_id": 203452, + "image_name": "120263.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 81.794, + 3244.099, + 1333.739, + 191.7579999999998 + ], + "priority": 13, + "parents": [ + 75717 + ], + "children": [], + "area": 265347.833606, + "iscrowd": 0, + "segmentation": [], + "text": "Each subject showed significant modulations of the N170/P200 components by the level of\nstimulus noise, and at the group level, significant effects were observed very early (within\n100 ms) and in the N170 time-window (Figure 2)* A*regression analysis showed that the of\nstimulus noise was stronger with age later on (R200), i.e. it takes longer for older subjects\nto process stimulus information [4]." + }, + { + "id": 75737, + "strid": "53b719d0-a57d-4ba1-b1a7-19cdadfc592d", + "image_id": 203452, + "image_name": "120263.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 48.017, + 3481.126, + 1345.006, + 898.866 + ], + "priority": 14, + "parents": [ + 75717 + ], + "children": [ + 75732 + ], + "area": 167153.22714200002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 75732, + "strid": "5d65a9e0-443f-4639-a2a6-9b754cf9f656", + "image_id": 203452, + "image_name": "120263.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 82.096, + 4420.236, + 1327.309, + 153.4920000000002 + ], + "priority": 15, + "parents": [ + 75737 + ], + "children": [], + "area": 362883.694656, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2. Results showing the effect-of noise on face ERP. The top panels show the effects\nin one subject and the bottomypanels show the effect of age on the modulatory effectof\nnoise (regression). Maps show the F values at p<0.05 corrected for multiple comparisons\nusing TFCE." + }, + { + "id": 75718, + "strid": "bd7202a4-8ef9-46c2-83e8-62e755ee3f30", + "image_id": 203452, + "image_name": "120263.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1484.041, + 810.026, + 525.106, + 46.053 + ], + "priority": 16, + "parents": [ + 75740 + ], + "children": [ + 75735, + 75729 + ], + "area": 1202111.795066, + "iscrowd": 0, + "segmentation": [], + "text": "PowerSpectrum Analyses" + }, + { + "id": 75729, + "strid": "a06c2e4f-d811-44af-8111-54719ecc596b", + "image_id": 203452, + "image_name": "120263.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1490.289, + 911.591, + 1436.892, + 152.06100000000004 + ], + "priority": 17, + "parents": [ + 75718 + ], + "children": [], + "area": 1358534.039799, + "iscrowd": 0, + "segmentation": [], + "text": "Significant modulations of the power spectrum were observed. in most subjects, but no significant\neffect emerged at the group level (Figure 3). This can be explained by the change in ERP shape /\nstimulus noise relationship with age, which shows up asa Significant modulation of power at ~17\n\nHz with age." + }, + { + "id": 75735, + "strid": "111a7448-c6c2-478b-815b-75ec317aa6fd", + "image_id": 203452, + "image_name": "120263.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1512.906, + 1098.634, + 1381.23, + 913.4110000000001 + ], + "priority": 18, + "parents": [ + 75718 + ], + "children": [ + 75730 + ], + "area": 1662129.970404, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 75730, + "strid": "363ab75e-1adf-4008-8227-a1638050376a", + "image_id": 203452, + "image_name": "120263.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1491.055, + 2047.856, + 1387.9529999999997, + 152.8599999999999 + ], + "priority": 19, + "parents": [ + 75735 + ], + "children": [], + "area": 3053465.92808, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3. Results showing the effect of noise on face evoked Power. The top panels show the\neffects in one subject and the bottom panels show the effect of age on the modulatory effect\nof noise (regression). Maps show the ‘fF values at p<0.05 corrected for multiple comparisons\nusing TFCE." + }, + { + "id": 75719, + "strid": "e447f7fc-d94d-4a58-8b01-b77937a63c88", + "image_id": 203452, + "image_name": "120263.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1487.045, + 2246.458, + 277.64699999999993, + 46.50799999999981 + ], + "priority": 20, + "parents": [ + 75740 + ], + "children": [ + 75736, + 75728 + ], + "area": 3340584.1366100004, + "iscrowd": 0, + "segmentation": [], + "text": "ERSP Analysis" + }, + { + "id": 75728, + "strid": "33a79948-ebf1-412b-bc40-1dbe729fd990", + "image_id": 203452, + "image_name": "120263.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1497.571, + 2319.918, + 1441.0749999999998, + 114.09400000000005 + ], + "priority": 21, + "parents": [ + 75719 + ], + "children": [], + "area": 3474241.919178, + "iscrowd": 0, + "segmentation": [], + "text": "The time-frequency decomposition showed again significant effects at the subject tevel (Figure 4)\nbut failed to show significant effect across subjects. Non-corrected results suggést modulation\neffect in the,alpha fange, as expected from ERP and Power analyses" + }, + { + "id": 75736, + "strid": "9f5c6e99-6249-40fd-bf1b-930d938bb673", + "image_id": 203452, + "image_name": "120263.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1495.025, + 2460.0, + 1422.002, + 839.0239999999999 + ], + "priority": 22, + "parents": [ + 75719 + ], + "children": [ + 75731 + ], + "area": 3677761.5, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 75731, + "strid": "f09b5087-512b-4d1a-9fa4-72422dfc5f6c", + "image_id": 203452, + "image_name": "120263.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1507.876, + 3348.215, + 1396.0869999999998, + 152.4920000000002 + ], + "priority": 23, + "parents": [ + 75736 + ], + "children": [], + "area": 5048693.04134, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 4. New LIMO EEG interface for time-frequency analysis. Results show the effect of noise\non ERSP“to faces in one subject. Maps show the F values at p<0.05,/corrected for multiple\ncomparisons using TFCE. The topographic plot shows the F yalue distribution on the scalp at\n14Hz. Under the map, the blue trace shows the frequency.distribution at electrode B8." + }, + { + "id": 75720, + "strid": "3d52a2f5-af8a-469e-9a26-1e15cbce9481", + "image_id": 203452, + "image_name": "120263.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1486.962, + 3563.45, + 208.74, + 37.8420000000001 + ], + "priority": 24, + "parents": [ + 75740 + ], + "children": [ + 75727 + ], + "area": 5298714.738899999, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion" + }, + { + "id": 75727, + "strid": "453851bb-390d-47e9-b6a2-374aca21e6ce", + "image_id": 203452, + "image_name": "120263.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1497.207, + 3645.956, + 1419.365, + 350.16600000000017 + ], + "priority": 25, + "parents": [ + 75720 + ], + "children": [], + "area": 5458750.844892001, + "iscrowd": 0, + "segmentation": [], + "text": "LIMO EEG offers a unique combination of tools.to“analyze ERP, Power and ERSP through a GUI, or\nbatch mode, or command line. The data import*is done automatically using the EEGLAB format\nbut the code is flexible enough to process data from any software. The only ‘major’ problem\nfor now is that Matlab is memory hungfy.. While ERP and power analysis can be performed on\nalmost any new computer, processing\\the full time-frequency space requires large memory\n(8Gb minimum), preferably in combination with solid state hard drives (store and retrieve\nmatrices from ~1Gb to ~4Gb): Similarly, bootstrapping can be slow when the search space is\nlarge. Future work will incorporate the analyses of component from ICA so that again, the full\ndata space can be analysed." + }, + { + "id": 75722, + "strid": "41f600f9-db31-4efb-8c69-393560dc8892", + "image_id": 203452, + "image_name": "120263.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1481.863, + 4517.567, + 353.51700000000005, + 46.04100000000017 + ], + "priority": 26, + "parents": [ + 75740 + ], + "children": [], + "area": 6694415.387321, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgment" + }, + { + "id": 75721, + "strid": "667813e8-c5e1-4eac-8af0-bd5d3edb4b9c", + "image_id": 203452, + "image_name": "120263.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1485.905, + 4044.851, + 230.99700000000007, + 38.253999999999905 + ], + "priority": 27, + "parents": [ + 75740 + ], + "children": [ + 75738 + ], + "area": 6010264.325155, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 75738, + "strid": "175295b4-12ab-4163-a444-088f9e9430b4", + "image_id": 203452, + "image_name": "120263.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1491.398, + 4126.372, + 1483.244, + 309.35199999999986 + ], + "priority": 28, + "parents": [ + 75721 + ], + "children": [], + "area": 6154062.948056, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 31083, + "strid": "58baefc5-124c-4f23-8061-84b18f840696", + "image_id": 201718, + "image_name": "117564.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 3097.25, + 203.78, + 301.9000000000001, + 283.03999999999996 + ], + "priority": -1, + "parents": [], + "children": [ + 31060, + 31082, + 31058, + 31054, + 31057, + 31056, + 31061, + 31062, + 31055, + 31059 + ], + "area": 631157.605, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 31054, + "strid": "784ed754-a56c-4132-b924-60ec0bb69c3b", + "image_id": 201718, + "image_name": "117564.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 100.599, + 50.956, + 2855.312, + 411.744 + ], + "priority": 1, + "parents": [ + 31083 + ], + "children": [], + "area": 5126.122644000001, + "iscrowd": 0, + "segmentation": [], + "text": "Budget Impact Analysis of Peritoneal Dialysis vs.\nConventionakin-center Hemodialysis in the United\nKingdom" + }, + { + "id": 31055, + "strid": "ede202e1-0ea6-489f-b556-f4d8527eab9b", + "image_id": 201718, + "image_name": "117564.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 101.591, + 547.85, + 1890.729, + 318.1039999999999 + ], + "priority": 2, + "parents": [ + 31083 + ], + "children": [], + "area": 55656.629349999996, + "iscrowd": 0, + "segmentation": [], + "text": "Frank Xiaoqing-biu', Robert Leipold?, Murat Arici?, Usman Farooqui*\n1 Baxter Healthcare Corporation, Deerfield, IL 60015 USA;\n\n2 United BioSource Corporation, Bethesda, MD:20814 USA;\n\n3 Baxter Healthcare Ltd., Compton, RG20 7QW United Kingdom." + }, + { + "id": 31056, + "strid": "4dae8479-7409-4e44-bf9c-cc0c95186dee", + "image_id": 201718, + "image_name": "117564.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 148.226, + 1049.635, + 272.05, + 53.22700000000009 + ], + "priority": 3, + "parents": [ + 31083 + ], + "children": [ + 31065, + 31066, + 31063, + 31064 + ], + "area": 155583.19751, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 31063, + "strid": "b094c8eb-d23c-415b-a40f-9541feee29bd", + "image_id": 201718, + "image_name": "117564.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 148.146, + 1137.209, + 660.968, + 602.115 + ], + "priority": 4, + "parents": [ + 31056 + ], + "children": [], + "area": 168472.964514, + "iscrowd": 0, + "segmentation": [], + "text": "Objectives: The increasing prevalence of\npatients with end-stage renal disease\n(ESRD) is driving up the costs of dialysis\ncare dramatically. The National Institute\nof Clinical Excellence (NICE) has\nprojected significant cost savings by\nincreasing the proportion of patients on\nperitoneal dialysis (PD). This study\ninvestigates the five-year budget impact\non UK national healthcare spending on\ndialysis of changing the distribution of\nadult patients undergoing peritoneal\ndialysis and in-center hemodialysis\n(ICHD)." + }, + { + "id": 31064, + "strid": "c9c61e59-3a75-4684-99f2-737afd1ec604", + "image_id": 201718, + "image_name": "117564.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 148.527, + 1757.95, + 670.3409999999999, + 1341.363 + ], + "priority": 5, + "parents": [ + 31056 + ], + "children": [], + "area": 261103.03965, + "iscrowd": 0, + "segmentation": [], + "text": "Methods: An Excel®-based budget\nimpact model was constructed to assess\ndialysis-associated costs when changing\nadult patients between PD and ICHD.\nThe model incorporates the current\nmodality distribution in the UK and\naccounts for dialysis payments, drug\ncosts (including ESAs), and the costs and\nprobabilities of adverse events including\naccess failure, access infection,\npneumonia, and cardiovascular events.\nData from the UK Renal Registry reports\nwere used to estimate the size of the UK\nadult dialysis patient population for the\nnext five years. The baseline scenario\nassumed a stable distribution of PD\n(15%) and ICHD (82%) over five years;\nthe remaining 3% is assumed to be home\nhemodialysis. Alternative scenarios\nincluded: 1). increasing the prevalence of\nPD by 1.5% each year for five years; 2).\nincreasing the prevalence of PD by 3.0%\neach year for five years; 3). decreasing\nthe prevalence of PD by 1.5% each year\nfor five years. All three scenarios were\naccompanied by commensurate changes\nin ICHD,;assuming no change in home\nhemodialysis. Differences among\nscenarios were evaluated in terms of\ncosts to UK National Health Services\n(NHS)." + }, + { + "id": 31065, + "strid": "9297d51e-0153-4201-907b-ab5a31408928", + "image_id": 201718, + "image_name": "117564.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 147.518, + 3118.479, + 669.042, + 474.6500000000001 + ], + "priority": 6, + "parents": [ + 31056 + ], + "children": [], + "area": 460031.785122, + "iscrowd": 0, + "segmentation": [], + "text": "Results: Under the current UK national\ntariff, an increase in the prevalent PD\npopulation from 15% in 2013 to 21% or\n27% in 2017 is predicted to result in five-\nyear cumulative savings for NHS of £28.3\nmillion and £78.9 million, respectively. If\nthe prevalent PD population were to\ndecrease from 15% in 2013 to 9.0% by\n2017, the total NHS payment for adult\ndialysis patients would increase by £73.0\nmillion over the next five years." + }, + { + "id": 31066, + "strid": "ad85783a-889f-4b5e-a0e1-67758b8e8d6c", + "image_id": 201718, + "image_name": "117564.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 146.325, + 3613.404, + 675.0049999999999, + 294.56899999999996 + ], + "priority": 7, + "parents": [ + 31056 + ], + "children": [], + "area": 528731.3402999999, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions: Under the current UK\nnational tariff, incentives to increase the\nproportion of patients on PD could help\nreduce dialysis-associated costs. The\nmain driver of the savings comes from the\nreduction.of the estimated transportation\ncosts." + }, + { + "id": 31059, + "strid": "adb7bac1-6633-42b8-9e93-7a6a5b03038d", + "image_id": 201718, + "image_name": "117564.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 92.755, + 4013.688, + 385.528, + 65.51699999999983 + ], + "priority": 8, + "parents": [ + 31083 + ], + "children": [ + 31067 + ], + "area": 372289.63044, + "iscrowd": 0, + "segmentation": [], + "text": "Background" + }, + { + "id": 31067, + "strid": "ce1f2a7e-ee62-4881-b75e-34ff88e690ba", + "image_id": 201718, + "image_name": "117564.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 85.789, + 4099.359, + 782.506, + 1133.3689999999997 + ], + "priority": 9, + "parents": [ + 31059 + ], + "children": [], + "area": 351679.90925100003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 31057, + "strid": "4f210880-6baf-4a6f-b0ee-de08200af657", + "image_id": 201718, + "image_name": "117564.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 965.312, + 972.26, + 300.44999999999993, + 66.3409999999999 + ], + "priority": 10, + "parents": [ + 31083 + ], + "children": [ + 31068 + ], + "area": 938534.24512, + "iscrowd": 0, + "segmentation": [], + "text": "Objective" + }, + { + "id": 31068, + "strid": "3348ed64-8ddf-4214-bc99-b39d64308dea", + "image_id": 201718, + "image_name": "117564.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 963.616, + 1058.822, + 747.415, + 168.96000000000004 + ], + "priority": 11, + "parents": [ + 31057 + ], + "children": [], + "area": 1020297.8203519998, + "iscrowd": 0, + "segmentation": [], + "text": "To.investigate the 5-year budget impact on UK\nnational healthcare spending for patients with\nESRD by changing the distribution of PD and\nICHD, while HHD remains constant." + }, + { + "id": 31058, + "strid": "844a006a-e93a-463c-9ae6-99a35c9296c1", + "image_id": 201718, + "image_name": "117564.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 978.366, + 1269.414, + 270.85400000000004, + 52.61999999999989 + ], + "priority": 12, + "parents": [ + 31083 + ], + "children": [ + 31074, + 31081, + 31075, + 31069 + ], + "area": 1241951.497524, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 31069, + "strid": "57a5cb03-2d0c-429c-8f5c-66e88f358137", + "image_id": 201718, + "image_name": "117564.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 970.638, + 1354.591, + 762.227, + 2136.725 + ], + "priority": 13, + "parents": [ + 31058 + ], + "children": [], + "area": 1314817.499058, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 31081, + "strid": "81383907-bd9d-4509-99b1-9c1e05225560", + "image_id": 201718, + "image_name": "117564.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1863.844, + 1068.148, + 713.9670000000001, + 535.835 + ], + "priority": 14, + "parents": [ + 31058 + ], + "children": [ + 31080 + ], + "area": 1990861.240912, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 31080, + "strid": "4eea2aff-a0eb-4aa4-9bec-517f045cfaf6", + "image_id": 201718, + "image_name": "117564.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1856.985, + 985.002, + 447.3860000000002, + 41.08699999999999 + ], + "priority": 15, + "parents": [ + 31081 + ], + "children": [], + "area": 1829133.9389699998, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. Model structure" + }, + { + "id": 31074, + "strid": "78867a28-fdbf-4285-8e72-9d1e5d39ce56", + "image_id": 201718, + "image_name": "117564.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 982.182, + 3615.407, + 1660.4109999999998, + 1376.5909999999994 + ], + "priority": 16, + "parents": [ + 31058 + ], + "children": [ + 31073 + ], + "area": 3550987.6780740004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 31073, + "strid": "38e4341c-12cb-4b92-99c9-d313406db69d", + "image_id": 201718, + "image_name": "117564.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 988.869, + 3554.311, + 508.6149999999999, + 50.414999999999964 + ], + "priority": 17, + "parents": [ + 31074 + ], + "children": [], + "area": 3514747.964259, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1: Model inputs" + }, + { + "id": 31075, + "strid": "7726aaad-3cba-4659-b85f-c1b0ab4ba196", + "image_id": 201718, + "image_name": "117564.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1782.779, + 2990.77, + 859.46, + 535.4169999999999 + ], + "priority": 18, + "parents": [ + 31058 + ], + "children": [ + 31076 + ], + "area": 5331881.94983, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 31076, + "strid": "d1a99562-63ac-40e6-94e8-9ae906b42fca", + "image_id": 201718, + "image_name": "117564.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1788.578, + 2881.099, + 803.3830000000003, + 87.89400000000023 + ], + "priority": 19, + "parents": [ + 31075 + ], + "children": [], + "area": 5153070.287222, + "iscrowd": 0, + "segmentation": [], + "text": "Table 2: Cumulative costs,by resource type\n(Values in £1000s)" + }, + { + "id": 31061, + "strid": "865eac19-07dc-4e6b-abec-bb3954621e81", + "image_id": 201718, + "image_name": "117564.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1843.159, + 1688.848, + 237.13099999999986, + 53.57600000000002 + ], + "priority": 20, + "parents": [ + 31083 + ], 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"551fcbf5-3134-4d3a-86e6-adc232213605", + "image_id": 201718, + "image_name": "117564.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2704.613, + 1073.567, + 775.0880000000002, + 1105.3900000000003 + ], + "priority": 23, + "parents": [ + 31082 + ], + "children": [], + "area": 2903583.264571, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 31078, + "strid": "04b801c0-eadc-4538-9112-75bd0b66677a", + "image_id": 201718, + "image_name": "117564.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2690.862, + 2331.927, + 818.395, + 535.364 + ], + "priority": 24, + "parents": [ + 31082 + ], + "children": [ + 31077 + ], + "area": 6274893.751074, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 31077, + "strid": "0b8bcfe6-8cef-463f-8300-c11fad5db478", + "image_id": 201718, + "image_name": "117564.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2697.299, + 2223.437, + 757.7380000000003, + 85.82799999999997 + ], + "priority": 25, + "parents": [ + 31078 + ], + "children": [], + "area": 5997274.396663, + "iscrowd": 0, + "segmentation": [], + "text": "Table 3: Per patient cost averaged over 5\nyears (Values-in £)" + }, + { + "id": 31062, + "strid": "43bb2165-bcc1-46e0-b68c-6ac9d407f5ec", + "image_id": 201718, + "image_name": "117564.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2776.134, + 2980.477, + 396.26800000000003, + 53.277000000000044 + ], + "priority": 26, + "parents": [ + 31083 + ], + "children": [ + 31079 + ], + "area": 8274203.535917999, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 31079, + "strid": "25dc0f3d-844a-47c6-bd1a-da0e06610d96", + "image_id": 201718, + "image_name": "117564.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2771.739, + 3068.608, + 678.9850000000001, + 1347.866 + ], + "priority": 27, + "parents": [ + 31062 + ], + "children": [], + "area": 8505380.469312001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 31060, + "strid": "dd167312-079f-4ad0-87a4-7a12797c3343", + "image_id": 201718, + "image_name": "117564.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 987.426, + 5013.405, + 628.2620000000001, + 66.9380000000001 + ], + "priority": 28, + "parents": [ + 31083 + ], + "children": [ + 31071 + ], + "area": 4950366.44553, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements" + }, + { + "id": 31071, + "strid": "8515735e-3d11-4c61-9c78-a1aa0df25927", + "image_id": 201718, + "image_name": "117564.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 989.427, + 5100.016, + 1610.4609999999998, + 84.97400000000016 + ], + "priority": 29, + "parents": [ + 31060 + ], + "children": [], + "area": 5046093.530832, + "iscrowd": 0, + "segmentation": [], + "text": "This study was conducted by United BioSource Corporation, Lexington, MA 02420 and supported by\nfunding from Baxter Healthcare Corporation, Deerfield, IL 60015 USA." + }, + { + "id": 195890, + "strid": "8f72476f-473d-469d-a269-193d60b3a877", + "image_id": 208170, + "image_name": "9558.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 753.95, + 138.5, + 156.38, + 139.01 + ], + "priority": -1, + "parents": [], + "children": [ + 195859, + 195889, + 195887, + 195874, + 195888, + 195860, + 195857, + 195858 + ], + "area": 104422.07500000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 195857, + "strid": "957cf351-5143-462f-a157-3574a1ecc0bd", + "image_id": 208170, + "image_name": "9558.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 1136.84, + 184.594, + 3108.1619999999994, + 132.889 + ], + "priority": 1, + "parents": [ + 195890 + ], + "children": [], + "area": 209853.84295999998, + "iscrowd": 0, + "segmentation": [], + "text": "The effect of task and target size on the north effect" + }, + { + "id": 195858, + "strid": "d8b4a9ac-ea43-48e1-8036-98b55fd4cac2", + "image_id": 208170, + "image_name": "9558.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1497.828, + 335.363, + 2514.405, + 435.316 + ], + "priority": 2, + "parents": [ + 195890 + ], + "children": [], + "area": 502316.091564, + "iscrowd": 0, + "segmentation": [], + "text": "E. Leslie Cameron'’:2, Michael W. Levine2:*, Jennifer E. Anderson24\nDepartment of Psychological Science, Carthage College\nDepartment of Psychology, University of Illinois at Chicago\n3 Laboratory of Integrative Neuroscience, University of Illinois at Chicago\nDepartment of Behavioral Sciences, Purdue University Calumet" + }, + { + "id": 195859, + "strid": "6ca3c11c-6e62-493a-8d72-f4945251b96c", + "image_id": 208170, + "image_name": "9558.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 499.231, + 862.441, + 570.8219999999999, + 64.13099999999997 + ], + "priority": 3, + "parents": [ + 195890 + ], + "children": [ + 195864, + 195865, + 195866 + ], + "area": 430557.282871, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 195865, + "strid": "5bbb0e45-da10-4021-b45e-0879913f97e4", + "image_id": 208170, + "image_name": "9558.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 115.727, + 964.318, + 1431.79, + 323.6969999999999 + ], + "priority": 4, + "parents": [ + 195859 + ], + "children": 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+ { + "id": 195874, + "strid": "2a376b99-47dc-48d6-96d6-c820bb982c64", + "image_id": 208170, + "image_name": "9558.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3313.54, + 865.872, + 340.16399999999976, + 67.88 + ], + "priority": 15, + "parents": [ + 195890 + ], + "children": [ + 195876, + 195885, + 195879, + 195882, + 195878, + 195881, + 195884, + 195880, + 195883, + 195873, + 195875, + 195877 + ], + "area": 2869101.50688, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 195873, + "strid": "490c1bd2-ccca-4ad5-839a-4fb1a61f85e2", + "image_id": 208170, + "image_name": "9558.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1636.983, + 972.326, + 2400.249, + 700.848 + ], + "priority": 16, + "parents": [ + 195874 + ], + "children": [], + "area": 1591681.132458, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 195880, + "strid": "eaa93044-a821-41f3-ae77-06c54853c214", + "image_id": 208170, + "image_name": "9558.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1889.945, + 1727.207, + 2032.061, + 129.69100000000003 + ], + "priority": 17, + "parents": [ + 195874 + ], + "children": [], + "area": 3264326.2336150003, + "iscrowd": 0, + "segmentation": [], + "text": "Normalized proportion correct is plotted as a function of location for 2 SFs and 2 sizes, fit with hemiellipses. Performance is\nparticularly poor on the VM, but poor performance extends beyond it. Smaller targets do not result in larger North or South\neffects. There is an upper visual field advantage." + }, + { + "id": 195875, + "strid": "109ccd18-319d-4a1b-9e61-06995ba584e7", + "image_id": 208170, + "image_name": "9558.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 4116.475, + 964.664, + 1054.4480000000003, + 714.1029999999998 + ], + "priority": 18, + "parents": [ + 195874 + ], + "children": [], + "area": 3971015.2394000003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 195881, + "strid": "05edb0de-61b0-4b3d-a90b-5e180cb9722d", + "image_id": 208170, + "image_name": "9558.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4182.611, + 1702.57, + 1045.9659999999994, + 171.17599999999993 + ], + "priority": 19, + "parents": [ + 195874 + ], + "children": [], + "area": 7121188.0102699995, + "iscrowd": 0, + "segmentation": [], + "text": "d’ is plotted as a function of location for squares of two sizes, fit\nwith hemiellipses. Performance is poor on the VM even for a\nsimple detection task. Smaller targets do not result in larger\nNorth or South effects." + }, + { + "id": 195876, + "strid": "dbfb6645-5db3-458a-9c7a-b8d9cc2a2675", + "image_id": 208170, + "image_name": "9558.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1641.678, + 1969.027, + 2415.0210000000006, + 311.75 + ], + "priority": 20, + "parents": [ + 195874 + ], + "children": [], + "area": 3232508.3073060005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 195884, + "strid": "04118534-ee69-4ae1-bdf9-cc198ea965bd", + "image_id": 208170, + "image_name": "9558.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1859.133, + 2359.076, + 2092.26, + 175.12699999999995 + ], + "priority": 21, + "parents": [ + 195874 + ], + "children": [], + "area": 4385836.041108, + "iscrowd": 0, + "segmentation": [], + "text": "Contrasts, the difference between actual performance and performance predicted by hemi-ellipse, normalized by ellipse size,\nas a function of distance from the VM, averaged across left and right visual fields. Upper visual field is represented in blue and\nlower visual field in red. Error bars reflect 95% confidence intervals. Larger North effect at high SF. Poor performance\nextends only to about 1 degree." + }, + { + "id": 195877, + "strid": "8ca0668c-02e2-4614-ba62-eecf384d2117", + "image_id": 208170, + "image_name": "9558.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 4107.108, + 1976.946, + 1131.255, + 303.28200000000015 + ], + "priority": 22, + "parents": [ + 195874 + ], + "children": [], + "area": 8119530.732168, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 195882, + "strid": "6c8abc00-8ef4-4922-a5e8-ee20b6be5755", + "image_id": 208170, + "image_name": "9558.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4171.403, + 2362.567, + 1041.728, + 177.33399999999983 + ], + "priority": 23, + "parents": [ + 195874 + ], + "children": [], + "area": 9855219.071501, + "iscrowd": 0, + "segmentation": [], + "text": "Contrast (as in figures to the left) as a function of distance from\nthe VM, averaged across left and right visual fields. Poor\nperformance is constrained to be near the VM; more so at the\nsmaller target size." + }, + { + "id": 195878, + "strid": "1f41d478-cd93-48a0-861f-d944ae889115", + "image_id": 208170, + "image_name": "9558.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1645.489, + 2583.229, + 2418.287, + 402.1300000000001 + ], + "priority": 24, + "parents": [ + 195874 + ], + "children": [], + "area": 4250674.903981, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 195885, + "strid": "36756f7f-ae0f-4982-b165-eb718a3d10c1", + "image_id": 208170, + "image_name": "9558.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1871.46, + 3052.552, + 2076.753, + 173.69500000000016 + ], + "priority": 25, + "parents": [ + 195874 + ], + "children": [], + "area": 5712728.96592, + "iscrowd": 0, + "segmentation": [], + "text": "Performance as a function of angle from fixation for upper (blue) and lower (red) visual fields. Dashed-dotted line reflects\nexpected performance if the visual field were homogenous (i.e., circular). Dotted blue line reflects expected performance if\nperformance increased linearly by angle from the VM. Solid green line reflects hemi-ellipse fit. None of these models capture\nknown visual field inhomogeneities, particularly the North and South effects." + }, + { + "id": 195879, + "strid": "6597382a-854b-4bec-a4c2-95d7dd7b908e", + "image_id": 208170, + "image_name": "9558.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 4144.629, + 2579.862, + 1123.562, + 404.34000000000015 + ], + "priority": 26, + "parents": [ + 195874 + ], + "children": [], + "area": 10692570.861198, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 195883, + "strid": "bfb1a22f-ea49-4285-8b37-337574dc0907", + "image_id": 208170, + "image_name": "9558.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4166.401, + 3048.355, + 1071.0439999999999, + 169.43600000000015 + ], + "priority": 27, + "parents": [ + 195874 + ], + "children": [], + "area": 12700669.320355, + "iscrowd": 0, + "segmentation": [], + "text": "d’ as a function of angle from fixation (same layout as figures to\nthe left). The linear model is slightly better for simple detection\nthan for orientation discrimination as the North and South effects\nare more constrained to VM." + }, + { + "id": 195887, + "strid": "2636acb7-b95b-4db7-92b5-32984d01a093", + "image_id": 208170, + "image_name": "9558.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2242.319, + 3361.044, + 797.29, + 50.90700000000015 + ], + "priority": 28, + "parents": [ + 195890 + ], + "children": [ + 195861 + ], + "area": 7536532.821036, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 195861, + "strid": "81cfd2cf-9383-4f85-9125-bca1375e03c7", + "image_id": 208170, + "image_name": "9558.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1675.008, + 3454.715, + 1927.1609999999998, + 482.53999999999996 + ], + "priority": 29, + "parents": [ + 195887 + ], + "children": [], + "area": 5786675.26272, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 195888, + "strid": "6ccf4017-c674-47a0-b4ab-0695f2be2cbc", + "image_id": 208170, + "image_name": "9558.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4247.12, + 3852.564, + 456.28799999999956, + 52.81800000000021 + ], + "priority": 30, + "parents": [ + 195890 + ], + "children": [ + 195863 + ], + "area": 16362301.61568, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements" + }, + { + "id": 195863, + "strid": "1a688f83-8dda-420d-a075-9addf9d4bb2e", + "image_id": 208170, + "image_name": "9558.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3655.921, + 3926.662, + 1553.851, + 76.55499999999984 + ], + "priority": 31, + "parents": [ + 195888 + ], + "children": [], + "area": 14355566.065701999, + "iscrowd": 0, + "segmentation": [], + "text": "This study was supported by intramural funds from Carthage College. Thanks to Leslie Krause for assistance\nwith data collection and to the stalwart participants." + }, + { + "id": 195889, + "strid": "244e2475-31c4-45cd-829c-8a35287fa958", + "image_id": 208170, + "image_name": "9558.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4279.956, + 3346.734, + 292.2640000000001, + 34.90299999999979 + ], + "priority": 32, + "parents": [ + 195890 + ], + "children": [ + 195862 + ], + "area": 14323874.263704, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 195862, + "strid": "9bff4ce8-4be2-4612-9ae9-f83053f275e3", + "image_id": 208170, + "image_name": "9558.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3655.536, + 3409.509, + 1616.6540000000005, + 284.94399999999996 + ], + "priority": 33, + "parents": [ + 195889 + ], + "children": [], + "area": 12463582.891824, + "iscrowd": 0, + "segmentation": [], + "text": "Abrams, J., Nizam, A. & Carrasco, M. (2012). Isoeccentricity locations are not equivalent: The extent of the vertical meridian asymmetry.\nVision Research, 52, 70-88.\n\nAnderson, J.E., Cameron, E.L. & Levine, M.W. (2014). A method for quantifying visual field inhomogeneities. Vision Research, 105,\n112-120.\n\nCameron, E.L. & Rathje, A.D. (2006, May). Target visibility determines the extent of visual field inhomogeneities. Poster presented at the\nAnnual Meeting of Vision Sciences, Sarasota, FL.\n\nCarrasco, M., Penpeci—Talgar, C. & Cameron, E.L. (2001). Characterizing visual performance fields: Effects of transient covert attention,\nspatial frequency, eccentricity, task and set size. Spatial Vision, 15.1, 61-75.\nLevine, M.W. & McAnany, J.J. (2005). The relative capabilities of the upper and lower visual hemifields. Vision Research, 45, 2820-2830." + }, + { + "id": 193571, + "strid": "242901ef-489f-45e1-9513-2d68e7dd7a69", + "image_id": 208069, + "image_name": "9309.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 248, + 638.66, + 355.35, + 261.49 + ], + "priority": -1, + "parents": [], + "children": [ + 193552, + 193564, + 193550, + 193563, + 193551, + 193553 + ], + "area": 158387.68, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 193550, + "strid": "bfd12ac6-44e9-47c2-abae-9afa3bbdd52c", + "image_id": 208069, + "image_name": "9309.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 150.624, + 180.589, + 3002.202, + 215.95 + ], + "priority": 1, + "parents": [ + 193571 + ], + "children": [], + "area": 27201.037536, + "iscrowd": 0, + "segmentation": [], + "text": "POLISH ADAPTATION OF SEXUAL ADDICTION SCREENING TEST — REVISED\n(SAST-PL)" + }, + { + "id": 193551, + "strid": "539c8727-fec9-4685-a87c-e705b6f398a4", + "image_id": 208069, + "image_name": "9309.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 930.159, + 514.773, + 1430.516, + 307.4789999999999 + ], + "priority": 2, + "parents": [ + 193571 + ], + "children": [], + "area": 478820.738907, + "iscrowd": 0, + "segmentation": [], + "text": "Ewelina Kowalewska 1, Mateusz Gola 23\n\n1SWPS University of Social Sciences and Humanities,\n2 Institute of Psychology, Polish Academy of Sciences\n3 Institute for Neural Computations, University of California, San Diego" + }, + { + "id": 193552, + "strid": "d82c983f-eaaa-4643-bd8f-1270987aa20b", + "image_id": 208069, + "image_name": "9309.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 664.465, + 1100.555, + 382.30000000000007, + 60.394000000000005 + ], + "priority": 3, + "parents": [ + 193571 + ], + "children": [ + 193554 + ], + "area": 731280.278075, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 193554, + "strid": "35f5fab6-9a09-4f21-9103-bbc738b76b70", + "image_id": 208069, + "image_name": "9309.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 117.071, + 1199.373, + 1482.183, + 496.5830000000001 + ], + "priority": 4, + "parents": [ + 193552 + ], + "children": [], + "area": 140411.796483, + "iscrowd": 0, + "segmentation": [], + "text": "Problematic hipersexual behaviors are gaining more and more attention from\nresearchers and clinicans. There is also a noticeable increase of interest in support\ngroups and Internet forums for people experiencing these problems. For research\nand clinical purpose it is important to develop an objective methods of measurment\nof problematic hipersexual behaviors. There are actually 25 different English\nlanguage questionnaires for assessing the severity of probelmatic hipersexual\nbehaviors. None of them have been adapted and validated in a Polish language\nversion. The main aim of our work was to make such an adaptation of the Sexual\nAddiction Screening Test — Revised (SAST-R; Carnes et al., 2010), the most popular\nand oldest questionnaire." + }, + { + "id": 193553, + "strid": "6f0df59f-c8af-45fa-bc7f-e2930c7720a6", + "image_id": 208069, + "image_name": "9309.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 540.436, + 1737.013, + 640.3170000000001, + 62.32899999999995 + ], + "priority": 5, + "parents": [ + 193571 + ], + "children": [ + 193570, + 193568, + 193556, + 193567, + 193555, + 193558, + 193557, + 193559, + 193569, + 193561, + 193562, + 193560 + ], + "area": 938744.357668, + "iscrowd": 0, + "segmentation": [], + "text": "Methods and Results" + }, + { + "id": 193557, + "strid": "837db982-320b-48c5-b90e-3655f515c8d6", + "image_id": 208069, + "image_name": "9309.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 88.213, + 1857.677, + 760.877, + 1625.2120000000002 + ], + "priority": 6, + "parents": [ + 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"category_id": 9, + "category_name": "Root", + "bbox": [ + 613.26, + 22.05, + 107.27999999999997, + 274.89 + ], + "priority": -1, + "parents": [], + "children": [ + 194754, + 194750, + 194747, + 194749, + 194752, + 194753, + 194755, + 194748, + 194751 + ], + "area": 13522.383, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 194747, + "strid": "4276fd8b-02c0-4b2c-b106-d37efc96a568", + "image_id": 208121, + "image_name": "9413.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 774.685, + 73.718, + 2110.807, + 269.858 + ], + "priority": 1, + "parents": [ + 194771 + ], + "children": [], + "area": 57108.22883, + "iscrowd": 0, + "segmentation": [], + "text": "“ RADSIM”\n\nUse of Toys as Play Model for Basic Training for Medical Radiation\nEmergency & Disaster Response" + }, + { + "id": 194748, + "strid": "25c7d85b-22df-4ddb-9bfe-3516d44506fd", + "image_id": 208121, + "image_name": "9413.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 704.389, + 431.919, + 1448.7849999999999, + 87.80399999999997 + ], + "priority": 2, + "parents": [ + 194771 + ], + "children": [], + "area": 304238.992491, + "iscrowd": 0, + "segmentation": [], + "text": "Alzamani Idrose, Kamadev Sonamuthu, Abu Hassan Asaari Abdullah\nEmergency Department, Hospital Kuala Lumpur 50608 Kuala Lumpur, MALAYSIA" + }, + { + "id": 194749, + "strid": "92058f8a-7fc3-4024-b882-e04d88b2fa6e", + "image_id": 208121, + "image_name": "9413.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 645.45, + 597.554, + 595.7839999999999, + 68.74400000000003 + ], + "priority": 3, + "parents": [ + 194771 + ], + "children": [ + 194756, + 194757 + ], + "area": 385691.2293, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 194756, + "strid": "0cf93c80-f312-4808-a8ff-e37d0c3c919c", + "image_id": 208121, + "image_name": "9413.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 140.323, + 747.237, + 1577.8, + 493.65999999999997 + ], + "priority": 4, + "parents": [ + 194749 + ], + "children": [], + "area": 104854.537551, + "iscrowd": 0, + "segmentation": [], + "text": "Adequate training and exposure to various aspects of Radiation Emergencies is\nessential for better understanding and enhancing preparedness for any such\nsituations. However, to prepare a group of healthcare professionals for radiation\nresponse can be quite challenging. Traditional method of disaster management\ntraining involves “disaster drills” has challenge of limitations such as being\nexpensive, time consuming, requiring man power and costly utilities. Many\nbureaucratic red tapes need to be traversed to involve an interagency or even\ninterdepartmental effort." + }, + { + "id": 194757, + "strid": "f17a6533-a9b9-4408-a0b1-a2a060918b60", + "image_id": 208121, + "image_name": "9413.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 130.074, + 1351.261, + 1537.854, + 233.3520000000001 + ], + "priority": 5, + "parents": [ + 194749 + ], + "children": [], + "area": 175763.923314, + "iscrowd": 0, + "segmentation": [], + "text": "Purpose of the Study\nTo establish a play model for response simulation for basic training of\nRadiation Emergency and Disaster Medical Response that makes\nradiation training and understanding easy and fun." + }, + { + "id": 194751, + "strid": "650aee2c-de00-43d3-8276-d057c7ae572d", + "image_id": 208121, + "image_name": "9413.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 654.015, + 1653.851, + 619.649, + 61.66399999999999 + ], + "priority": 6, + "parents": [ + 194771 + ], + "children": [ + 194765, + 194758, + 194759 + ], + "area": 1081643.361765, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 194758, + "strid": "003b7f00-8022-42a1-927b-c005d80505f6", + "image_id": 208121, + "image_name": "9413.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 149.256, + 1793.341, + 1595.314, + 1122.649 + ], + "priority": 7, + "parents": [ + 194751 + ], + "children": [], + "area": 267666.90429599996, + "iscrowd": 0, + "segmentation": [], + "text": "A group of 30 emergency physicians were subjected to a pre-test questions\nregarding radiation emergency medical knowledge and management. The scores\nobtained formed the baseline knowledge of participants. Following this, a short\ntraining utilizing toys and models were conducted. The ‘toys’ consisted two sets\n‘spidermen’ — black and red representing contaminated and non-contaminated\nradiation following an ‘explosion’ incident. Areas of management as\nrecommended by international Atomic Energy Agency documents were ‘staged’\nas play model placed on the floor. By utilizing these toy module,participants were\ntaught regarding the principles of radiation emergency medical management\nwhich included agencies and personnel involved, areas for security,\n\nscreening ,decontamination, specimen management, secured entry and exit\nwhile the wind direction was utilized. Participants were encouraged to respond\nfreely and even make mistakes while the ‘scenario’ evolved as a simulation.\nPeriodically, the simulations were ‘paused’ where participants’ responses were\nevaluated, feedback given and correct response were taught. At the end of\ntraining, participants took similar test and the scores assessed. Participants were\nalso asked to evaluate this training module. This module of training is called\n‘RADSIM’." + }, + { + "id": 194765, + "strid": "60a4d214-a618-42ea-811d-75c5567a339d", + "image_id": 208121, + "image_name": "9413.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 121.331, + 2976.597, + 1592.327, + 527.3510000000001 + ], + "priority": 8, + "parents": [ + 194751 + ], + "children": [], + "area": 361153.490607, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 194759, + "strid": "05e3a9c4-f6ac-4c3e-b030-c115c11aa3fd", + "image_id": 208121, + "image_name": "9413.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 136.764, + 3514.551, + 1588.0679999999998, + 174.47699999999986 + ], + "priority": 9, + "parents": [ + 194751 + ], + "children": [], + "area": 480664.05296400003, + "iscrowd": 0, + "segmentation": [], + "text": "Toys in the form of ‘spiderman’ were used in a module of mass casualty\ninvolving radiation emergency. Participants ‘played’ the game and learn\nin a fun manner." + }, + { + "id": 194753, + "strid": "e4eebbcb-6cb3-4995-b7d6-8c38428ad4d9", + "image_id": 208121, + "image_name": "9413.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 243.772, + 3736.415, + 1387.287, + 66.1239999999998 + ], + "priority": 10, + "parents": [ + 194771 + ], + "children": [ + 194760 + ], + "area": 910833.35738, + "iscrowd": 0, + "segmentation": [], + "text": "LESSON LEARNT AND CONCLUSION" + }, + { + "id": 194760, + "strid": "6a88cf60-24ae-43d6-ad8d-e169200710dd", + "image_id": 208121, + "image_name": "9413.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 151.304, + 3850.161, + 1540.156, + 370.3770000000004 + ], + "priority": 11, + "parents": [ + 194753 + ], + "children": [], + "area": 582544.759944, + "iscrowd": 0, + "segmentation": [], + "text": "Emergency Physicians participating in this training concluded that radiation\nsimulation training utilizing toys was fun, made understanding radiation\nmanagement principies easy while it provides multidimensional understanding\nwhich lecture alone could not achieve, They recommend that this method\nshould be used as training tool and would recommend this method of training\nfor management of radiation incident in mass casualty setting." + }, + { + "id": 194750, + "strid": "fbf3552d-0229-472a-9f37-cdffeb2faafc", + "image_id": 208121, + "image_name": "9413.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2457.553, + 603.696, + 352.67599999999993, + 60.76099999999997 + ], + "priority": 12, + "parents": [ + 194771 + ], + "children": [ + 194767, + 194772, + 194766, + 194768, + 194764, + 194763, + 194769 + ], + "area": 1483614.915888, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 194768, + "strid": "8eebf07e-577f-4aed-8abf-94d50204d668", + "image_id": 208121, + "image_name": "9413.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1880.281, + 711.494, + 672.6190000000001, + 505.86299999999994 + ], + "priority": 13, + "parents": [ + 194750 + ], + "children": [], + "area": 1337808.6498140001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 194769, + "strid": "091a39ba-aefc-4d8b-87b9-5c1eae1781cc", + "image_id": 208121, + "image_name": "9413.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2730.595, + 714.031, + 640.0140000000001, + 505.9459999999999 + ], + "priority": 14, + "parents": [ + 194750 + ], + "children": [], + "area": 1949729.4784449998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 194764, + "strid": "4e314728-64ac-4c84-b5c8-33a7d57f947e", + "image_id": 208121, + "image_name": "9413.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1883.339, + 1244.756, + 1562.2939999999999, + 236.54899999999998 + ], + "priority": 15, + "parents": [ + 194750 + ], + "children": [], + "area": 2344297.5202840003, + "iscrowd": 0, + "segmentation": [], + "text": "30 emergency physicians (mean age 35 + 3.12) 65% male and 35%\nfemale took part in RADSIM. Pre-test score was 61.24 + 10.50 %. The\npost-test score was 90.55 + 5.15 % (P< 0.05). There was a significant\nrise of score following RADSIM." + }, + { + "id": 194767, + "strid": "acc92b58-681e-4a7e-bdc7-a1114262d5a4", + "image_id": 208121, + "image_name": "9413.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1858.621, + 1510.899, + 1138.674, + 1321.9770000000003 + ], + "priority": 16, + "parents": [ + 194750 + ], + "children": [], + "area": 2808188.610279, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 194772, + "strid": "df76e0f0-f6d5-4df8-a24a-6ba9f8928589", + "image_id": 208121, + "image_name": "9413.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1951.458, + 1635.089, + 976.5990000000002, + 57.30600000000004 + ], + "priority": 17, + "parents": [ + 194750 + ], + "children": [], + "area": 3190807.509762, + "iscrowd": 0, + "segmentation": [], + "text": "Emergency Physicians’ views (%) N=30" + }, + { + "id": 194766, + "strid": "1be85efc-54ad-4de2-a987-404f16aae47c", + "image_id": 208121, + "image_name": "9413.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3020.794, + 1665.203, + 431.96500000000015, + 723.4650000000001 + ], + "priority": 18, + "parents": [ + 194750 + ], + "children": [], + "area": 5030235.231182, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 194763, + "strid": "d9af1169-1127-44e5-804b-e14f69cf35f7", + "image_id": 208121, + "image_name": "9413.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3037.256, + 2438.972, + 411.45899999999983, + 331.27 + ], + "priority": 19, + "parents": [ + 194750 + ], + "children": [], + "area": 7407782.340832001, + "iscrowd": 0, + "segmentation": [], + "text": "Participants made\nup of Emergency\nPhysicians\nprovided positive\nfeedback to\nRADSIM" + }, + { + "id": 194752, + "strid": "70dde236-0457-46f3-9ba5-53354d63edad", + "image_id": 208121, + "image_name": "9413.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2424.729, + 2897.052, + 479.09299999999985, + 61.67099999999982 + ], + "priority": 20, + "parents": [ + 194771 + ], + "children": [ + 194762 + ], + "area": 7024565.998908, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 194762, + "strid": "8b06ec0f-5a5a-4535-8e9b-f37d58fce528", + "image_id": 208121, + "image_name": "9413.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1904.711, + 3027.749, + 1476.5909999999997, + 561.6289999999999 + ], + "priority": 21, + "parents": [ + 194752 + ], + "children": [], + "area": 5766986.825538999, + "iscrowd": 0, + "segmentation": [], + "text": "Since preparation and training for radiation disaster preparedness can be\nlimited due to the existing challenges, we propose utilizing of toys as\nsimulation tools for radiation emergency response training. We believe this\nmethod would be more efficient and immersive method especially to the\nentry level participants. Malaysian Emergency Department healthcare\npersonnel in general, do not receive adequate training in radiation\nemergency mitigation and management. This approach is suitable as it\nwould provide hands on approach and conceptual framework in the\nparticipants mind before attempting a full scale disaster drill." + }, + { + "id": 194754, + "strid": "813c4080-f73b-4d3f-bcca-028e717601ef", + "image_id": 208121, + "image_name": "9413.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2183.123, + 3741.419, + 979.9320000000002, + 63.78200000000015 + ], + "priority": 22, + "parents": [ + 194771 + ], + "children": [ + 194761 + ], + "area": 8167977.871537, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 194761, + "strid": "dea8c736-277a-42a5-b8ad-12b2ac27e0d9", + "image_id": 208121, + "image_name": "9413.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1941.317, + 3873.727, + 1399.458, + 414.70700000000033 + ], + "priority": 23, + "parents": [ + 194754 + ], + "children": [], + "area": 7520132.078459, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 194755, + "strid": "87267c97-16e5-41c4-8d82-b35461e03e61", + "image_id": 208121, + "image_name": "9413.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1519.256, + 4384.296, + 529.1229999999998, + 64.38699999999972 + ], + "priority": 24, + "parents": [ + 194771 + ], + "children": [ + 194770 + ], + "area": 6660868.003776001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 194770, + "strid": "212d5af5-7128-4264-9f60-aec092f5dd9d", + "image_id": 208121, + "image_name": "9413.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 147.735, + 4488.569, + 3298.207, + 232.17600000000039 + ], + "priority": 25, + "parents": [ + 194755 + ], + "children": [], + "area": 663118.7412150002, + "iscrowd": 0, + "segmentation": [], + "text": "1. Idrose AM, Adnan WA, Villa GF, Abdullah AH. The use of classroom training and simulation in the training of medical responders for airport disaster. Emerg Med J. 2007 Jan;24(1):7-11. Review\n2. Hutchinson SW, Haynes §S, Parker P, Dennis B, McLin C, Welldaregay W. Implementing a multidisciplinary disaster simulation for undergraduate nursing students. Nurs Educ Perspect. 2011 Jul-Aug;32(4):240-3.\n\n3. Franc JM, Nichols D, Dong SL. Increasing emergency medicine residents’ confidence in disaster management: use of an emergency department simulator and an expedited curriculum. Prehosp Disaster Med. 2012 Feb;27(1):31-5. doi: 10.1017/S1049023X11006807.\n\nPE) LEME COA SGT SY clikes Selatan erly Cae cn F. Nationwide program of education for undergraduates in the field of disaster medicine: development of a core curriculum centered on blended learning and simulation tools. Prehosp Disaster Med. 2014 Oct;" + }, + { + "id": 11964, + "strid": "3dee7bd6-0c5d-48bb-9b27-d58a66687987", + "image_id": 200982, + "image_name": "11403.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 165.51, + 130.12, + 356.62, + 316.99 + ], + "priority": -1, + "parents": [], + "children": [ + 11967, + 11979, + 11970, + 11965, + 11986, + 11981, + 11978, + 11977, + 11980, + 11982, + 11984, + 11985, + 11983, + 11974, + 11973, + 11971, + 11975, + 11976, + 11966 + ], + "area": 21536.1612, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 11965, + "strid": "6f7be1f1-5849-4078-95a1-0f87de92eee0", + "image_id": 200982, + "image_name": "11403.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 790.76, + 123.248, + 2020.265, + 263.976 + ], + "priority": 1, + "parents": [ + 11964 + ], + "children": [], + "area": 97459.58848, + "iscrowd": 0, + "segmentation": [], + "text": "NGL Viewer & Library\nVersatile molecular graphics on the web" + }, + { + "id": 11966, + "strid": "73328303-3a18-4015-8b34-ff402d7ae92b", + "image_id": 200982, + "image_name": "11403.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1343.767, + 452.034, + 910.3509999999999, + 61.398000000000025 + ], + "priority": 2, + "parents": [ + 11964 + ], + "children": [], + "area": 607428.372078, + "iscrowd": 0, + "segmentation": [], + "text": "Alexander S. Rose, Stephen K. Burley" + }, + { + "id": 11967, + "strid": "a4a373b6-d745-49dc-9fed-63e8dd90a586", + "image_id": 200982, + "image_name": "11403.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 675.113, + 788.235, + 225.34500000000003, + 48.63099999999997 + ], + "priority": 3, + "parents": [ + 11964 + ], + "children": [ + 11969 + ], + "area": 532147.6955550001, + "iscrowd": 0, + "segmentation": [], + "text": "Overview" + }, + { + "id": 11969, + "strid": "1c2de74e-6d1f-47eb-b0d0-f76708a06d81", + "image_id": 200982, + "image_name": "11403.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 318.121, + 888.776, + 938.8660000000001, + 492.59399999999994 + ], + "priority": 4, + "parents": [ + 11967 + ], + "children": [], + "area": 282738.30989599996, + "iscrowd": 0, + "segmentation": [], + "text": "Interactive visualization, annotation and sharing of\nlarge macromolecular complexes is more important\nthan ever but is becoming challenging as experimental\ntechniques advance at an unprecedented rate. The\nweb can provide easy access to the resulting\nvisualizations for all interested parties, including\ncolleagues, collaborators, reviewers and educators.\nHerein, we utilize the web-based NGL library to provide\n3D visualization of experimental and computational\ndata integrated with general molecular graphics." + }, + { + "id": 11970, + "strid": "59f8e498-d2fb-4985-a9a2-69097908025f", + "image_id": 200982, + "image_name": "11403.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1465.452, + 784.397, + 1194.144, + 800.9500000000002 + ], + "priority": 5, + "parents": [ + 11964 + ], + "children": [], + "area": 1149496.1524440001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 11973, + "strid": "d84cbc89-0f14-4350-a5f2-07e1847a97fa", + "image_id": 200982, + "image_name": "11403.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2892.023, + 795.237, + 371.5160000000001, + 707.2489999999999 + ], + "priority": 6, + "parents": [ + 11964 + ], + "children": [], + "area": 2299843.694451, + "iscrowd": 0, + "segmentation": [], + "text": "Format support\n\nStructure:\nmmCIF,\nPDB/PQR,\nGRO, SDF,\nMOL2, MMTF\n\nTrajectory: PSF & DCD, TOP\n& TRR/XTC, PRMTOP &\nNCTRAJ\n\nVolume: MRC/MAP/CCP4,\nDSN6/BRIX, CUBE,\nDX/DXBIN, XPLOR/CNS\nSurface: OBJ, PLY\n\nGeneral: CSV, JSON,\nMSGPACK, TXT, XML" + }, + { + "id": 11976, + "strid": "ab2cbbef-2f36-4306-929c-8e6c4373ee7b", + "image_id": 200982, + "image_name": "11403.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 341.492, + 1774.131, + 805.4760000000001, + 214.423 + ], + "priority": 7, + "parents": [ + 11964 + ], + "children": [], + "area": 605851.543452, + "iscrowd": 0, + "segmentation": [], + "text": "Working with molecules\n\nThe Structure class provides iterators for the\nmolecular hierarchy and data access via proxies" + }, + { + "id": 11974, + "strid": "43751d53-7b46-406a-8a51-1a8af8c004bd", + "image_id": 200982, + "image_name": "11403.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 293.142, + 2050.987, + 940.2559999999999, + 390.39699999999993 + ], + "priority": 8, + "parents": [ + 11964 + ], + "children": [], + "area": 601230.431154, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 11978, + "strid": "b526b7a2-3f53-4009-87b2-2e98314d3ea4", + "image_id": 200982, + "image_name": "11403.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1406.048, + 1774.392, + 898.78, + 264.72399999999993 + ], + "priority": 9, + "parents": [ + 11964 + ], + "children": [], + "area": 2494880.322816, + "iscrowd": 0, + "segmentation": [], + "text": "The molecular world is but a stage\n\nThere is one object to rule them all, the Stage. To\ndraw on the canvas follow the central dogma of NGL\n“Stage -> Component -> Representation’." + }, + { + "id": 11977, + "strid": "fe48cfa7-8c34-427b-a96b-e0667f7c23f0", + "image_id": 200982, + "image_name": "11403.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1344.644, + 2180.014, + 1035.579, + 261.067 + ], + "priority": 10, + "parents": [ + 11964 + ], + "children": [], + "area": 2931342.7450160002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 11980, + "strid": "6127bca0-655a-4539-a7d8-07ff265ee572", + "image_id": 200982, + "image_name": "11403.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2498.7, + 1775.863, + 789.9520000000002, + 311.54200000000014 + ], + "priority": 11, + "parents": [ + 11964 + ], + "children": [], + "area": 4437348.878099999, + "iscrowd": 0, + "segmentation": [], + "text": "Animation & user interaction\n\nAnimation controls to orient the whole scene\nor individual components. Mouse controls to\nbind actions to mouse and keyboard, including\nclicking or hovering atoms or other elements" + }, + { + "id": 11979, + "strid": "03003a6b-a675-4084-b837-c228c937f56c", + "image_id": 200982, + "image_name": "11403.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2481.795, + 2204.691, + 825.915, + 239.1260000000002 + ], + "priority": 12, + "parents": [ + 11964 + ], + "children": [], + "area": 5471591.100345, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 11986, + "strid": "94e40080-9969-4e19-ab1d-e0f60a740c31", + "image_id": 200982, + "image_name": "11403.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 302.972, + 2656.255, + 907.815, + 280.8609999999999 + ], + "priority": 13, + "parents": [ + 11964 + ], + "children": [], + "area": 804770.88986, + "iscrowd": 0, + "segmentation": [], + "text": "Volume Data\n\nVolumetric data can be rendered as isosurfaces, point\nclouds or volume slices. Moreover, volume data can\nbe used for coloring structures and other volumes." + }, + { + "id": 11983, + "strid": "a414eef3-8cd2-4dac-9a70-044cea8a85c0", + "image_id": 200982, + "image_name": "11403.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 299.847, + 3049.423, + 915.9300000000001, + 738.2510000000002 + ], + "priority": 14, + "parents": [ + 11964 + ], + "children": [], + "area": 914360.3382809999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 11984, + "strid": "4f8f4b8d-5730-49d8-ad5a-d7b1e7bf7fcb", + "image_id": 200982, + "image_name": "11403.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1481.681, + 2657.161, + 809.9670000000001, + 269.98900000000003 + ], + "priority": 15, + "parents": [ + 11964 + ], + "children": [], + "area": 3937064.967641, + "iscrowd": 0, + "segmentation": [], + "text": "Molecular Data & Coloring\n\nMolecular data can be displayed as balls, sticks,\ncartoons, surfaces and labels or with specialized\nrepresentations such as hyperballs and ropes." + }, + { + "id": 11985, + "strid": "eaed9532-a008-42d3-ac7c-989406dbe586", + "image_id": 200982, + "image_name": "11403.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1454.974, + 3047.251, + 997.644, + 756.9380000000001 + ], + "priority": 16, + "parents": [ + 11964 + ], + "children": [], + "area": 4433670.976474, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 11982, + "strid": "7fd40623-4c82-49e7-b462-d2a102ae34bc", + "image_id": 200982, + "image_name": "11403.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2671.208, + 2655.686, + 567.4090000000001, + 363.4859999999999 + ], + "priority": 17, + "parents": [ + 11964 + ], + "children": [], + "area": 7093889.688688001, + "iscrowd": 0, + "segmentation": [], + "text": "Custom Shapes\n\nA variety of shapes, including\nsphere, cylinder, ellipsoid, cone,\narrow, label, and mesh, are\navailable for custom rendering of\nuser data" + }, + { + "id": 11981, + "strid": "e1140a9c-df80-4b12-bfa7-4a054c2dbb53", + "image_id": 200982, + "image_name": "11403.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2681.259, + 3046.574, + 596.6500000000001, + 761.7539999999999 + ], + "priority": 18, + "parents": [ + 11964 + ], + "children": [], + "area": 8168653.956666, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 11971, + "strid": "caa0420d-ccdc-466b-9929-89b4ded82424", + "image_id": 200982, + "image_name": "11403.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 615.987, + 4027.477, + 776.8350000000002, + 61.90299999999979 + ], + "priority": 19, + "parents": [ + 11964 + ], + "children": [ + 11972, + 11968 + ], + "area": 2480873.4747989997, + "iscrowd": 0, + "segmentation": [], + "text": "Funding and acknowledgements" + }, + { + "id": 11968, + "strid": "e2d1c782-d438-43dc-88b9-0cd022f45908", + "image_id": 200982, + "image_name": "11403.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 322.168, + 4139.948, + 534.456, + 179.60499999999956 + ], + "priority": 20, + "parents": [ + 11971 + ], + "children": [], + "area": 1333758.7672640001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 11972, + "strid": "33683ec6-5beb-45de-92db-c1db809c8908", + "image_id": 200982, + "image_name": "11403.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1033.499, + 4138.68, + 656.508, + 190.9979999999996 + ], + "priority": 21, + "parents": [ + 11971 + ], + "children": [], + "area": 4277321.64132, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 11975, + "strid": "23d09a4b-95b6-4652-b711-c2be94553287", + "image_id": 200982, + "image_name": "11403.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2352.157, + 4026.019, + 483.259, + 63.78699999999981 + ], + "priority": 22, + "parents": [ + 11964 + ], + "children": [ + 11987 + ], + "area": 9469828.772983, + "iscrowd": 0, + "segmentation": [], + "text": "Software availability" + }, + { + "id": 11987, + "strid": "111fcd18-1a4d-452f-b136-3fdb5608bfef", + "image_id": 200982, + "image_name": "11403.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1947.358, + 4153.176, + 894.4550000000002, + 170.47199999999975 + ], + "priority": 23, + "parents": [ + 11975 + ], + "children": [], + "area": 8087720.509008001, + "iscrowd": 0, + "segmentation": [], + "text": "NGL Viewer & Library (https://github.com/arose/ngl)\nAS Rose & PW Hildebrand.\n\nNGL Viewer: a web application for molecular visualization.\nNucl. Acids Res. (1 July 2015) 43 (W1). doi:10.1093/nar/gkv402" + }, + { + "id": 48668, + "strid": "94d6da74-bc3b-441a-9e46-f2edc855c97f", + "image_id": 202405, + "image_name": "118659.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 44.55, + 0.94, + 192.19, + 192.19 + ], + "priority": -1, + "parents": [], + "children": [ + 48645, + 48662, + 48649, + 48667, + 48643, + 48637, + 48656, + 48652, + 48636, + 48639, + 48654, + 48646, + 48642, + 48664, + 48658, + 48647, + 48661, + 48648, + 48644, + 48650, + 48638, + 48635 + ], + "area": 41.876999999999995, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 48635, + "strid": "f6f784d7-10ae-43de-93e1-4d88a2b12058", + "image_id": 202405, + "image_name": "118659.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 391.049, + 110.743, + 2319.829, + 117.73599999999999 + ], + "priority": 1, + "parents": [ + 48668 + ], + "children": [], + "area": 43305.939407, + "iscrowd": 0, + "segmentation": [], + "text": "The Diversity of sponges from French Polynesia" + }, + { + "id": 48636, + "strid": "8d48b39a-37d1-4588-8ef7-30a06fc8892c", + "image_id": 202405, + "image_name": "118659.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 214.563, + 348.394, + 2821.879, + 205.414 + ], + "priority": 2, + "parents": [ + 48668 + ], + "children": [], + "area": 74752.461822, + "iscrowd": 0, + "segmentation": [], + "text": "Kathryn Hall’, Merrick Ekins?, Patricia Sutcliff?, John Hooper’, Sylvain Petek’, Eric Folcher®, Cécile Debitus*\n\n1 Queensland Museum, PO Box 3300, South Brisbane, Queensland 4101, Australia . 2 Eskitis Institute, Griffith University. 3 University of Queensland.\n4 IRD-UMR241, BP529, 98748 Papeete, French Polynesia. 5 IRD-SEOH, BP A5, 98713 Noumea, New Caledonia" + }, + { + "id": 48637, + "strid": "ce78ffbc-d886-4dab-aecf-5e3dfbb4623e", + "image_id": 202405, + "image_name": "118659.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 237.784, + 581.156, + 2957.345, + 641.396 + ], + "priority": 3, + "parents": [ + 48668 + ], + "children": [], + "area": 138189.59830399998, + "iscrowd": 0, + "segmentation": [], + "text": "INTRODUCTION. We report here on an extensive survey of sponges from French Polynesia, recording presence/absence and an estimate of local\nabundance on sites spread across 5 group of islands of French Polynesia (viz. the Marquesas Islands, Windward and Leeward Islands (comprising\nthe Society Islands), Tuamotu and Australes islands. Sponge distributions within archipelagos were relatively homogeneous, showing some\ndifferential patterns in affinities between each of them and approximately one-third of the fauna apparently endemic to these archipelagos, but\nbetween-archipelago comparisons showed large heterogeneity. The fauna of the Marquesas Islands (with sites consisting mostly of rocky slopes)\nwas dominated by species of Poecilosclerida, and showed a similar range of taxonomic diversity to the remote fauna of the Hawaiian Islands. By\ncomparison, the sponge fauna of the Society Islands, Tuamotu and Australes islands was dominated by Dictyoceratida, reflecting the predominance\nof coral reef and lagoon sites and associated phototrophic feeding strategies. Further investigation of Marquesas and Society islands using\nparsimony and multivariate statistical analyses to compare French Polynesian sponge faunas with others in the southwestern Pacific showed closest\nnested faunal similarities between the (Marquesas Islands + Society Islands)+(((Tonga + Fiji) + Vanuatu) + New Caledonia) +(North Great Barrier\nReef + South Great Barrier Reef), but no or very low similarity between more geographically isolated faunas such as Palau and the collective Great\nBarrier Reef fauna." + }, + { + "id": 48638, + "strid": "903cae88-eb37-44e5-b4b0-8b0acedaa2ad", + "image_id": 202405, + "image_name": "118659.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 229.983, + 1237.991, + 950.031, + 712.038 + ], + "priority": 4, + "parents": [ + 48668 + ], + "children": [ + 48641 + ], + "area": 284716.884153, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 48641, + "strid": "e1a9d07d-e1fd-4096-a98c-3297d74776b4", + "image_id": 202405, + "image_name": "118659.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 231.639, + 1974.492, + 899.1230000000002, + 90.81999999999994 + ], + "priority": 5, + "parents": [ + 48638 + ], + "children": [], + "area": 457369.352388, + "iscrowd": 0, + "segmentation": [], + "text": "Program of surveys of the sponge fauna of French\nPolynesia" + }, + { + "id": 48639, + "strid": "819ac692-b4ab-426e-990a-aa844ae57f70", + "image_id": 202405, + "image_name": "118659.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1284.936, + 1230.023, + 920.9280000000001, + 548.9590000000001 + ], + "priority": 6, + "parents": [ + 48668 + ], + "children": [ + 48640 + ], + "area": 1580500.8335279997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 48640, + "strid": "c1ea8034-7f95-4888-9094-f289712b1fde", + "image_id": 202405, + "image_name": "118659.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1279.072, + 1799.52, + 957.9550000000002, + 238.375 + ], + "priority": 7, + "parents": [ + 48639 + ], + "children": [], + "area": 2301715.6454399996, + "iscrowd": 0, + "segmentation": [], + "text": "French Polynesia in the gradient of Indo-west\nPacific biodiversity gradient based on coral species\ndiversity, with sponges showing similar decrease in\ndiversity between New Caledonia and French\nPolynesia" + }, + { + "id": 48643, + "strid": "ca41191c-5c2f-472c-a350-b29f7bc0767c", + "image_id": 202405, + "image_name": "118659.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2267.144, + 1219.98, + 536.087, + 402.06500000000005 + ], + "priority": 8, + "parents": [ + 48668 + ], + "children": [], + "area": 2765870.33712, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 48648, + "strid": "d862e3d4-999a-41f8-8da3-699f796c722f", + "image_id": 202405, + "image_name": "118659.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2826.979, + 1298.09, + 337.01200000000017, + 248.86899999999991 + ], + "priority": 9, + "parents": [ + 48668 + ], + "children": [], + "area": 3669673.1701099994, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 48644, + "strid": "b24de4b6-013a-4a18-a2d6-a33479a43c57", + "image_id": 202405, + "image_name": "118659.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2271.029, + 1631.756, + 532.2019999999998, + 435.0849999999998 + ], + "priority": 10, + "parents": [ + 48668 + ], + "children": [], + "area": 3705765.196924, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 48647, + "strid": "3315960f-b927-4171-9a5c-9d1180e92eb3", + "image_id": 202405, + "image_name": "118659.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2830.039, + 1652.015, + 330.9290000000001, + 370.00700000000006 + ], + "priority": 11, + "parents": [ + 48668 + ], + "children": [], + "area": 4675266.8785850005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 48645, + "strid": "79dd7df0-f4e1-4b34-b783-01583c978d8e", + "image_id": 202405, + "image_name": "118659.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2269.322, + 2081.825, + 540.7170000000001, + 313.1869999999999 + ], + "priority": 12, + "parents": [ + 48668 + ], + "children": [], + "area": 4724331.27265, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 48646, + "strid": "c8b27a43-240f-4e86-9fdb-622688319a04", + "image_id": 202405, + "image_name": "118659.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2833.046, + 2076.104, + 327.93499999999995, + 306.8040000000001 + ], + "priority": 13, + "parents": [ + 48668 + ], + "children": [], + "area": 5881698.132783999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 48642, + "strid": "da8bb536-9bc4-45f7-b355-a84dc792b5d3", + "image_id": 202405, + "image_name": "118659.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 184.502, + 2071.251, + 2013.7350000000001, + 269.48799999999983 + ], + "priority": 14, + "parents": [ + 48668 + ], + "children": [], + "area": 382149.95200200006, + "iscrowd": 0, + "segmentation": [], + "text": "STUDY AREA. We focused our interest on two groups of islands : Marquesas Islands (on its way to\nbecoming UNESCO world natural heritage listed), and Society Islands (which concentrate 85% of the\noverall population of French Polynesia and offers the most diverse range of habitats in this French\nterritory). Sponges from other group of islands (including the Tuamotu Archipelago) are currently\nbeing investigated." + }, + { + "id": 48649, + "strid": "0f58a223-11c7-404a-9615-eda7337eefc0", + "image_id": 202405, + "image_name": "118659.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 128.019, + 2346.994, + 401.01099999999997, + 302.03099999999995 + ], + "priority": 15, + "parents": [ + 48668 + ], + "children": [ + 48651 + ], + "area": 300459.824886, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 48651, + "strid": "7e779316-05d9-4bb2-9c53-ded9e24786f7", + "image_id": 202405, + "image_name": "118659.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 130.341, + 2658.741, + 838.659, + 141.72899999999981 + ], + "priority": 16, + "parents": [ + 48649 + ], + "children": [], + "area": 346542.960681, + "iscrowd": 0, + "segmentation": [], + "text": "Left: RV ‘Alis’. Right: Raiatea, Society Islands\n: high island surrounded by a_ fringing reef,\nlagoon and barrier reef." + }, + { + "id": 48650, + "strid": "ec0365ed-b412-4f91-a0eb-9fea3ce498dd", + "image_id": 202405, + "image_name": "118659.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 543.972, + 2349.009, + 443.999, + 297.96900000000005 + ], + "priority": 17, + "parents": [ + 48668 + ], + "children": [], + "area": 1277795.123748, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 48652, + "strid": "7952429b-550e-4713-bbba-c2ee6127be5f", + "image_id": 202405, + "image_name": "118659.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 996.711, + 2347.363, + 1274.278, + 877.8899999999999 + ], + "priority": 18, + "parents": [ + 48668 + ], + "children": [ + 48653 + ], + "area": 2339642.523093, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 48653, + "strid": "81feac77-3337-4402-b4e3-6eca9bf37169", + "image_id": 202405, + "image_name": "118659.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 954.002, + 3230.725, + 1302.013, + 147.05499999999984 + ], + "priority": 19, + "parents": [ + 48652 + ], + "children": [], + "area": 3082118.1114499997, + "iscrowd": 0, + "segmentation": [], + "text": "Distribution of sponges from two archipelagos in French Polynesia and\nelsewhere in the southwestern Pacific. Columns shaded in grey are\ntaxa common to both the Society and Marquesas Islands." + }, + { + "id": 48667, + "strid": "3fa120a2-ca68-48a2-9712-e7d7d310661d", + "image_id": 202405, + "image_name": "118659.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2309.887, + 2451.563, + 854.3969999999999, + 668.5889999999999 + ], + "priority": 20, + "parents": [ + 48668 + ], + "children": [ + 48666 + ], + "area": 5662833.503381001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 48666, + "strid": "f77a18a4-84a2-492c-ae7b-22f24e214dfd", + "image_id": 202405, + "image_name": "118659.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2307.884, + 3160.143, + 868.469, + 285.10300000000007 + ], + "priority": 21, + "parents": [ + 48667 + ], + "children": [], + "area": 7293243.4674120005, + "iscrowd": 0, + "segmentation": [], + "text": "Map of the southwestern Pacific overlain with\nhierarchical _ relationships indicated by\nmultivariate analysis (cluster analysis of\nvariables) of the faunas of the regions. Major\noceanic currents are overlain and indicated by\narrows." + }, + { + "id": 48654, + "strid": "2ef7219f-c23e-4906-914f-273758c34ee5", + "image_id": 202405, + "image_name": "118659.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 186.647, + 2841.575, + 670.886, + 487.4079999999999 + ], + "priority": 22, + "parents": [ + 48668 + ], + "children": [ + 48655 + ], + "area": 530371.449025, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 48655, + "strid": "15f18a38-c0f8-4c44-9c2e-3241b3c0cb82", + "image_id": 202405, + "image_name": "118659.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 151.112, + 3351.594, + 754.534, + 145.596 + ], + "priority": 23, + "parents": [ + 48654 + ], + "children": [], + "area": 506466.072528, + "iscrowd": 0, + "segmentation": [], + "text": "Comparison of the species diversity\n(number of species) of the sponge fauna\nof the Society and Marquesas Islands." + }, + { + "id": 48656, + "strid": "82f34992-1036-4cc4-acfb-66e3cc0aa0e0", + "image_id": 202405, + "image_name": "118659.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 127.994, + 3509.028, + 941.9809999999999, + 392.28499999999985 + ], + "priority": 24, + "parents": [ + 48668 + ], + "children": [ + 48657 + ], + "area": 449134.529832, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 48657, + "strid": "32e409c8-4f92-427d-b686-055adff850a2", + "image_id": 202405, + "image_name": "118659.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 132.303, + 3913.647, + 915.18, + 138.13999999999987 + ], + "priority": 25, + "parents": [ + 48656 + ], + "children": [], + "area": 517787.23904099996, + "iscrowd": 0, + "segmentation": [], + "text": "Bay of Virgins, Fatu Hiva, Marquesas islands:\nrocky steep slopes, no coral reef either fringing or\nbarrier reef" + }, + { + "id": 48661, + "strid": "d08ec7c5-1be9-4ae7-831d-452591f1c065", + "image_id": 202405, + "image_name": "118659.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1117.039, + 3433.687, + 822.556, + 729.1400000000003 + ], + "priority": 26, + "parents": [ + 48668 + ], + "children": [ + 48660 + ], + "area": 3835562.2927929997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 48660, + "strid": "435ee326-b336-42b2-932b-3316728afeee", + "image_id": 202405, + "image_name": "118659.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1026.696, + 4166.345, + 913.527, + 383.1909999999998 + ], + "priority": 27, + "parents": [ + 48661 + ], + "children": [], + "area": 4277569.74612, + "iscrowd": 0, + "segmentation": [], + "text": "Maximum Parsimony tree (PAUP) of shared\nsimilarities among the sponge faunas of the\nsouthwestern Pacific based on QM collections\nfrom these faunas (Bootstrap values are indicated\non each node, nreps = 1000). Refer to Pacific\nScience for tree specifications Cl = 0.697; HI =\n0.302; RC = 0.604. with uninformative characters\nexcluded)" + }, + { + "id": 48662, + "strid": "050edcb2-60e0-427b-96f9-d68d229a07dd", + "image_id": 202405, + "image_name": "118659.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2087.4, + 3506.947, + 346.45600000000013, + 43.05099999999993 + ], + "priority": 28, + "parents": [ + 48668 + ], + "children": [ + 48663 + ], + "area": 7320401.167800001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 48663, + "strid": "88639faa-bc8b-49a0-ae06-47c0c9f93c7c", + "image_id": 202405, + "image_name": "118659.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1995.27, + 3562.17, + 1201.3250000000003, + 489.83399999999983 + ], + "priority": 29, + "parents": [ + 48662 + ], + "children": [], + "area": 7107490.9359, + "iscrowd": 0, + "segmentation": [], + "text": "One-third of sponge species in both the Marquesas and\nSociety Islands are apparently endemic to each\narchipelago. This level of apparent endemism, the\ndispersal and colonization barrier due to geographical\nisolation and the historical patterns of dispersal eastward\nacross the Pacific, likely accounts for the reciprocal\nsimilarity of the faunas of the two archipelagos to each\nother and to the exclusion of other regions in the\nsouthwestern Pacific." + }, + { + "id": 48664, + "strid": "5c2dc15d-fbc4-4764-802c-3c1982493652", + "image_id": 202405, + "image_name": "118659.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2102.181, + 4065.047, + 442.9079999999999, + 42.916999999999916 + ], + "priority": 30, + "parents": [ + 48668 + ], + "children": [ + 48665 + ], + "area": 8545464.567507, + "iscrowd": 0, + "segmentation": [], + "text": "ACKNOWLEDGMENTS" + }, + { + "id": 48665, + "strid": "0bcc36c7-12c5-4c31-bc47-d9a384ba8871", + "image_id": 202405, + "image_name": "118659.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2014.109, + 4112.549, + 1173.3250000000003, + 240.6229999999996 + ], + "priority": 31, + "parents": [ + 48664 + ], + "children": [], + "area": 8283121.953841, + "iscrowd": 0, + "segmentation": [], + "text": "We thank IRD for funding this cruise, the Délégations a la\nrecherche from France and French Polynesia for funding the\nresearch project (Plan Etat-Territoire France - Polynésie\nfrangaise 2010-2011 “Marquesas project’), and the communities\nand fisheries department for their interest in our project." + }, + { + "id": 48658, + "strid": "f6585e1b-ad8a-47f8-b607-61c44466d7ae", + "image_id": 202405, + "image_name": "118659.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 264.181, + 4142.732, + 254.33800000000002, + 37.220000000000255 + ], + "priority": 32, + "parents": [ + 48668 + ], + "children": [ + 48659 + ], + "area": 1094431.082492, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 48659, + "strid": "b2a6852f-bce8-4277-a9c7-461cda7846a6", + "image_id": 202405, + "image_name": "118659.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 165.965, + 4186.726, + 782.755, + 348.14400000000023 + ], + "priority": 33, + "parents": [ + 48658 + ], + "children": [], + "area": 694849.9805899999, + "iscrowd": 0, + "segmentation": [], + "text": "Hall KA, Sutcliffe PR, Hooper JNA, Alencar\nA, Vacelet J, Pisera A, Petek S, Folcher E,\nButscher J, Orempuller J, Maihota N, &\nDebitus C. (2013). Affinities of Sponges\n(Porifera) of the Marquesas and Society\nIslands, French Polynesia. Pacific Science\n67(4): 493 — 511 (doi:10.2984/67.4.1)" + }, + { + "id": 124951, + "strid": "8d29c0f9-565a-448c-a5b8-96a8c619e8c1", + "image_id": 205365, + "image_name": "14942.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 117.48, + 259.58, + 183.03999999999996, + 288.64000000000004 + ], + "priority": -1, + "parents": [], + "children": [ + 124930, + 124934, + 124929, + 124931, + 124932, + 124948, + 124949, + 124933 + ], + "area": 30495.4584, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 124929, + "strid": "40814975-fcb9-4d42-b637-054a8055fce3", + "image_id": 205365, + "image_name": "14942.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 343.675, + 65.775, + 2557.679, + 206.246 + ], + "priority": 1, + "parents": [ + 124951 + ], + "children": [], + "area": 22605.223125000004, + "iscrowd": 0, + "segmentation": [], + "text": "Novel Type IV CRISPR-Cas System Element on Plasmids Carried by\nKPC-2-Producing Klebsiella pneumoniae Belonging to CG258." + }, + { + "id": 124930, + "strid": "9e820eed-15ac-4d0e-9b7c-c5b9636dcb12", + "image_id": 205365, + "image_name": "14942.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 340.198, + 275.461, + 2748.202, + 316.951 + ], + "priority": 2, + "parents": [ + 124951 + ], + "children": [], + "area": 93711.281278, + "iscrowd": 0, + "segmentation": [], + "text": "Louise Cerdeira', Margaret Lam?, Kelly Wyres?, Bruna Fuga’, Rosineide Ribas?, Kathryn Holt?4,\nNilton Lincopan’\n\n‘Department of Microbiology, Institute of Biomedical Sciences, University of SA0 Paulo, Sao Paulo, Brazil;*Department of Infectious\nDiseases, Central Clinical School, Monash University, Melbourne, Australia; * Federal University of Uberlandia, Institute of Biomedical\nSciences, Uberlandia, Brazil; “London School of Hygiene and Tropical Medicine, London, United Kingdom." + }, + { + "id": 124931, + "strid": "f0c6fac4-8a0b-49b9-a1d9-cfd44ddfbaf2", + "image_id": 205365, + "image_name": "14942.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 879.147, + 680.361, + 365.57499999999993, + 72.43299999999999 + ], + "priority": 3, + "parents": [ + 124951 + ], + "children": [ + 124935, + 124947 + ], + "area": 598137.332067, + "iscrowd": 0, + "segmentation": [], + "text": "Background" + }, + { + "id": 124947, + "strid": "378b90fd-36c5-49c2-a5cd-07ff181fafc9", + "image_id": 205365, + "image_name": "14942.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 50.018, + 854.697, + 2028.5609999999997, + 195.48400000000004 + ], + "priority": 4, + "parents": [ + 124931 + ], + "children": [], + "area": 42750.234546, + "iscrowd": 0, + "segmentation": [], + "text": "Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) have begun to\nbe described in clinically important pathogens, as an immune system against foreign\nDNA from phages and plasmids." + }, + { + "id": 124935, + "strid": "68c0bbf4-99e0-40a8-9875-7cb313c9aa35", + "image_id": 205365, + "image_name": "14942.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 51.326, + 1093.946, + 2021.386, + 131.42499999999995 + ], + "priority": 5, + "parents": [ + 124931 + ], + "children": [], + "area": 56147.872396, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 124932, + "strid": "bbb4a414-ad94-480c-9b98-b0bd0dc280df", + "image_id": 205365, + "image_name": "14942.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 908.995, + 1304.351, + 325.34399999999994, + 64.64100000000008 + ], + "priority": 6, + "parents": [ + 124951 + ], + "children": [ + 124939, + 124936 + ], + "area": 1185648.537245, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 124936, + "strid": "bc7ee85f-5a1e-4a2d-80f7-6cbef82e824a", + "image_id": 205365, + "image_name": "14942.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 68.1, + 1418.554, + 2028.201, + 477.961 + ], + "priority": 7, + "parents": [ + 124932 + ], + "children": [], + "area": 96603.52739999999, + "iscrowd": 0, + "segmentation": [], + "text": "A total of 40 K. pneumoniae isolates belonging to CG258 (ST11, ST340, ST258,\nST437) from human and non-human samples collected between 2006 and 2018, in\nBrazil, were screened by CRISPR-Cas system elements using short- (NextSeq) and\nlong (Nanopore)-read sequencing. Assembly and bioinformatics analysis were\nperformed using in house pipeline (Pipa), described in Figure 1. RT-PCR was\nperformed using LightCycler® RNA Amplification Kit SYBR Green (Roche Diagnostics\nLtd., UK)." + }, + { + "id": 124939, + "strid": "6909404e-632d-47db-b527-e551a3fba745", + "image_id": 205365, + "image_name": "14942.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 61.51, + 1900.622, + 2047.668, + 647.162 + ], + "priority": 8, + "parents": [ + 124932 + ], + "children": [ + 124942 + ], + "area": 116907.25922, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 124942, + "strid": "5ff2e597-2ada-4305-ade1-9979203b9955", + "image_id": 205365, + "image_name": "14942.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 71.302, + 2507.583, + 1144.251, + 31.6550000000002 + ], + "priority": 9, + "parents": [ + 124939 + ], + "children": [], + "area": 178795.68306600003, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1 — Detailed components'3.4.5.6.7.8.9.10.11 automated in our in house Bioinformatic pipeline (Pipa)" + }, + { + "id": 124933, + "strid": "1b062581-6865-414a-aaa2-d8ad27699e0c", + "image_id": 205365, + "image_name": "14942.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 952.247, + 2593.414, + 263.177, + 58.914000000000215 + ], + "priority": 10, + "parents": [ + 124951 + ], + "children": [ + 124945, + 124938, + 124941, + 124940 + ], + "area": 2469570.701258, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 124938, + "strid": "5a91c862-2bf4-4ec2-a554-ddc7df8765d6", + "image_id": 205365, + "image_name": "14942.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 57.303, + 2686.184, + 2032.799, + 900.5520000000001 + ], + "priority": 11, + "parents": [ + 124933 + ], + "children": [], + "area": 153926.401752, + "iscrowd": 0, + "segmentation": [], + "text": "We report the identification of a novel subtype of Type IV-A CRISPR-Cas (designated\nType IV-A1), exclusively associated with IncFIB(mar) and IncHI1B large plasmids in\nKPC-2-positive K. pneumoniae belonging to CG258, isolated from human hosts.\nAdditionally, a new genetic arrange carrying a new cas5-like gene and a highly\nconserved hypothetical protein were identified inside and downstream cas6 gene,\nrespectively. In addition, RT-PCR demonstrated that Type IV-A1 cas loci genes (cas7,\ncas5-like,dinG, cas6, conserved hypothetical protein) are expressed. Interestingly, the\npresence of Type IV-A1 CRISPR-Cas was confirmed in plasmids carried by K.\npneumoniae CG258 from European and Asian countries. It was possible identify at\nleast two photo space patterns for IncFIB(mar)/IncHI1B (Figure 2;Figure 3B). Whereas\nfor direct repeat was identify two patterns containing cas genes and one without cas\ngenes. Similar phage regions were present on the chromosome and plasmid that has\nresistance genes for at least 3 classes of antibiotics (Figure 4B)." + }, + { + "id": 124945, + "strid": "b06927f8-cb12-49c4-8f26-1ec7238309ab", + "image_id": 205365, + "image_name": "14942.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 53.673, + 3601.901, + 2019.385, + 662.049 + ], + "priority": 12, + "parents": [ + 124933 + ], + "children": [ + 124946 + ], + "area": 193324.832373, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 124946, + "strid": "6b7e8225-1780-48d6-83c8-c26a1f1a4fb6", + "image_id": 205365, + "image_name": "14942.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 67.33, + 4269.398, + 1540.855, + 28.872999999999593 + ], + "priority": 13, + "parents": [ + 124945 + ], + "children": [], + "area": 287458.56734, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2 — Alignment of spaces and direct repeats of CrispR loci. Where similar repeat or space region will show the same drawing pattern." + }, + { + "id": 124941, + "strid": "1640ce28-0e69-4fd1-9b9f-267779f20a24", + "image_id": 205365, + "image_name": "14942.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2144.739, + 642.966, + 1746.2379999999998, + 531.639 + ], + "priority": 14, + "parents": [ + 124933 + ], + "children": [ + 124943 + ], + "area": 1378994.255874, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 124943, + "strid": "23e30dd2-8730-489a-85c8-d33a7e32dbba", + "image_id": 205365, + "image_name": "14942.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2158.108, + 1183.209, + 1702.016, + 92.72000000000003 + ], + "priority": 15, + "parents": [ + 124941 + ], + "children": [], + "area": 2553492.8085720004, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3 — Detailed Alignment of spaces and direct repeat present in our sample and others K. pneumoniae obtained in public database (genbank).\nA- Alignment of direct repeats present in CrispR loci. B - Alignment of spaces present in present in CrispR loci. Where similar repeat or space region will\nshow the same drawing pattern." + }, + { + "id": 124940, + "strid": "72e07d26-3853-4c2c-9c47-a3e281ea7086", + "image_id": 205365, + "image_name": "14942.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2163.988, + 1285.757, + 1690.426, + 841.4410000000003 + ], + "priority": 16, + "parents": [ + 124933 + ], + "children": [ + 124944 + ], + "area": 2782362.718916, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 124944, + "strid": "e186107d-bedd-45ab-92f5-bc926fab6492", + "image_id": 205365, + "image_name": "14942.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2170.823, + 2176.349, + 1672.4190000000003, + 88.76299999999992 + ], + "priority": 17, + "parents": [ + 124940 + ], + "children": [], + "area": 4724468.465227, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 4 — A: Schematic cell invasion by two phages found on chromosome and plasmid. That’s represents: a) phage 1; b) chromosome; c) phages 2;\nd) plasmid, where the color show the shared region (>95% ID) with each phage. B: Whole genome sequence of the plasmid pKp1194d, a large plasmid\nBelongs to IncHI1B." + }, + { + "id": 124934, + "strid": "8b2dfa0c-06ef-49fc-af0b-77c1ab99ef60", + "image_id": 205365, + "image_name": "14942.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2790.864, + 2299.782, + 447.2800000000002, + 61.61499999999978 + ], + "priority": 18, + "parents": [ + 124951 + ], + "children": [ + 124937 + ], + "area": 6418378.7916480005, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 124937, + "strid": "136dd215-fa4f-452f-b191-dc2e97639e75", + "image_id": 205365, + "image_name": "14942.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2156.635, + 2406.023, + 1719.2070000000003, + 550.3760000000002 + ], + "priority": 19, + "parents": [ + 124934 + ], + "children": [], + "area": 5188913.412605001, + "iscrowd": 0, + "segmentation": [], + "text": "The presence of CRISPR-Cas system elements could contribute for\nadaptation and persistence of KPC-2-producing K. pneumoniae CG258\nin human hosts. On the other hand, most likely Type IV-A1 CRISPR-Cas\ncould provide specific immunity against plasmids of other incompatible\ngroups, conferring plasmid stability, as well as play a role for MGE’s\ndissemination. In addition, this system could be used for plasmid curing\nin bacteria. Finally, the spacer analysis suggests a role in plasmid\nincompatibility, supporting a plasmid typing approach." + }, + { + "id": 124948, + "strid": "a272ad99-8f27-4932-ba93-b9c99a4fc1b6", + "image_id": 205365, + "image_name": "14942.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2824.296, + 2994.641, + 385.471, + 55.51999999999998 + ], + "priority": 20, + "parents": [ + 124951 + ], + "children": [], + "area": 8457752.597736, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 124949, + "strid": "f8150099-049e-426e-9e16-71b1dce5f0c8", + "image_id": 205365, + "image_name": "14942.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2681.039, + 3467.939, + 709.1680000000001, + 55.86400000000003 + ], + "priority": 21, + "parents": [ + 124951 + ], + "children": [ + 124950 + ], + "area": 9297679.708621, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 124950, + "strid": "94a4dabf-dd60-4756-aa5a-e1fdf0783c9a", + 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"children": [], + "area": 22093.80777, + "iscrowd": 0, + "segmentation": [], + "text": "Instructor presence, visual attention, and learning in educational video: Content difficulty matters." + }, + { + "id": 6755, + "strid": "e5d62e5a-5899-4b3c-bc71-8bc05fc4615e", + "image_id": 200771, + "image_name": "10947.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1286.717, + 222.973, + 1935.4190000000003, + 115.60300000000001 + ], + "priority": 2, + "parents": [ + 6781 + ], + "children": [], + "area": 286903.149641, + "iscrowd": 0, + "segmentation": [], + "text": "Jiahui Wang', Pavlo Antonenko!, Ethan Fieldman?" + }, + { + "id": 6756, + "strid": "aece9b28-1d64-4357-9a23-a6ce3f50f198", + "image_id": 200771, + "image_name": "10947.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 115.542, + 447.938, + 374.8159999999999, + 62.786 + ], + "priority": 3, + "parents": [ + 6781 + ], + "children": [ + 6775, + 6777, + 6776 + ], + "area": 51755.652396, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 6775, + "strid": "6a6d79d0-69d1-4b47-a911-1a744b21d060", + "image_id": 200771, + "image_name": "10947.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 115.298, + 535.931, + 1343.922, + 292.571 + ], + "priority": 4, + "parents": [ + 6756 + ], + "children": [], + "area": 61791.77243800001, + "iscrowd": 0, + "segmentation": [], + "text": "In an effort to reach more students, educators work to design engaging\nonline learning experiences, particularly in the form of online videos.\nWhile many instructional videos feature a picture-in-picture view of\ninstructor, it is not clear how instructor presence influences learners’\nvisual attention and what it contributes to learning and affect." + }, + { + "id": 6777, + "strid": "b509d802-7945-42e5-bae9-ba0aa11ab2f4", + "image_id": 200771, + "image_name": "10947.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 110.541, + 845.152, + 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The two\nvideos with instructor presence were designed by Algebra Nation™.\nThe two videos without instructor presence were made by Khan\nAcademy™. Each participant watched two videos, either with or\nwithout instructor." + }, + { + "id": 6748, + "strid": "c52dde41-9ea7-414b-a996-5fb7642c0b52", + "image_id": 200771, + "image_name": "10947.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 90.651, + 3071.76, + 1400.214, + 428.05600000000004 + ], + "priority": 14, + "parents": [ + 6759 + ], + "children": [], + "area": 278458.11576, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 6757, + "strid": "a9c4e327-65a5-4fed-9c42-d6f79e749b89", + "image_id": 200771, + "image_name": "10947.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1626.22, + 440.328, + 527.0249999999999, + 85.61799999999994 + ], + "priority": 15, + "parents": [ + 6781 + ], + "children": [ + 6751, + 6765, + 6764, + 6752 + ], + "area": 716070.20016, + "iscrowd": 0, + "segmentation": [], + "text": "Results: Learning" + }, + { + "id": 6751, + "strid": "054bd935-384d-4ac9-8a90-300a95e26567", + "image_id": 200771, + "image_name": 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For mental effort\nquestion, 1= very, very low mental effort; 9 = very, very high mental effort." + }, + { + "id": 6766, + "strid": "ff5a5182-3f31-4b97-80de-57b5e3dbb429", + "image_id": 200771, + "image_name": "10947.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3319.869, + 1270.254, + 1337.9879999999998, + 340.7080000000001 + ], + "priority": 27, + "parents": [ + 6762 + ], + "children": [], + "area": 4217076.876726, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 6761, + "strid": "375c15c1-7583-4e12-a603-ef1d5a46a9f3", + "image_id": 200771, + "image_name": "10947.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3280.231, + 1725.783, + 314.7449999999999, + 68.24099999999999 + ], + "priority": 28, + "parents": [ + 6781 + ], + "children": [ + 6768 + ], + "area": 5660966.895873, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion" + }, + { + "id": 6768, + "strid": "9a777356-0893-419b-8697-b10ab4eed265", + "image_id": 200771, + "image_name": "10947.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3292.398, + 1829.818, + 1387.2780000000002, + 528.4889999999998 + ], + "priority": 29, + "parents": [ + 6761 + ], + "children": [], + "area": 6024489.123564, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 6760, + "strid": "1e48f4c4-6e4d-4353-81cf-94e392091095", + "image_id": 200771, + "image_name": "10947.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3282.778, + 2441.518, + 324.9699999999998, + 60.1880000000001 + ], + "priority": 30, + "parents": [ + 6781 + ], + "children": [ + 6770, + 6767, + 6779 + ], + "area": 8014961.577004, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion" + }, + { + "id": 6779, + "strid": "27a98d70-08da-43b6-ab6b-0e1e2d4a9701", + "image_id": 200771, + "image_name": "10947.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3282.002, + 2557.709, + 860.2549999999997, + 53.00199999999995 + ], + "priority": 31, + "parents": [ + 6760 + ], + "children": [], + "area": 8394406.053418, + "iscrowd": 0, + "segmentation": [], + "text": "Instructor presence in Mathematics video:" + }, + { + "id": 6767, + "strid": "48973aea-a35d-4df0-87e1-89b8abf57679", + "image_id": 200771, + "image_name": "10947.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3274.556, + 2641.861, + 1427.2580000000003, + 534.335 + ], + "priority": 32, + "parents": [ + 6760 + ], + "children": [], + "area": 8650921.788716, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 6770, + "strid": "802dafbc-89fe-4d9f-bfe6-15b006cc2141", + "image_id": 200771, + "image_name": "10947.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3320.673, + 3251.246, + 1314.3589999999995, + 221.01200000000017 + ], + "priority": 33, + "parents": [ + 6760 + ], + "children": [], + "area": 10796324.808558, + "iscrowd": 0, + "segmentation": [], + "text": "Future research could test the efficacy of instructor presence in other\nlearning contexts and with different populations of learners. It is also\nimperative to understand how learners with individual differences\nrespond to instructor presence in online videos." + }, + { + "id": 172293, + "strid": "40cf4468-88f3-4dfe-a7a5-00ca191745df", + "image_id": 207224, + "image_name": "7137.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 594.35, + 45.4, + 178.61, + 273.17 + ], + "priority": -1, + "parents": [], + "children": [ + 172280, + 172274, + 172277, + 172275, + 172279, + 172258, + 172276, + 172259, + 172278 + ], + "area": 26983.49, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 172258, + "strid": "b86d9853-a7d2-4b0e-9067-119a3fad23da", + "image_id": 207224, + "image_name": "7137.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 848.649, + 76.225, + 4635.409, + 316.323 + ], + "priority": 1, + "parents": [ + 172293 + ], + "children": [], + "area": 64688.270025, + "iscrowd": 0, + "segmentation": [], + "text": "Cognitive behavioral therapy-based exercise facilitation method using\nthe“Ikiiki Rehabilitation Notebook’ in patients with chronic pain" + }, + { + "id": 172259, + "strid": "8eb02419-5761-45d6-a1b3-a15f42388752", + "image_id": 207224, + "image_name": "7137.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1510.612, + 477.262, + 3365.349, + 348.454 + ], + "priority": 2, + "parents": [ + 172293 + ], + "children": [], + "area": 720957.7043440001, + "iscrowd": 0, + "segmentation": [], + "text": "Shinji Kimura, M.D., Ph.D., Yuichiro Sogawa, M.D., Toru Harigai, M.D.,\nNorie Nomoto, M.D., Naoto Endo, M.D., Ph.D.\nRehabilitation Center, Niigata Univ. Medical and Dental Hospital, Japan" + }, + { + "id": 172276, + "strid": "5a8a3c91-0d29-4416-b3a0-ce2f2ab746d6", + "image_id": 207224, + "image_name": "7137.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 99.498, + 939.929, + 385.984, + 58.77200000000005 + ], + "priority": 3, + "parents": [ + 172293 + ], + "children": [ + 172281, + 172282 + ], + "area": 93521.055642, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction:" + }, + { + "id": 172281, + "strid": "1a0e9bc1-217b-4b97-bf4c-38d946f0f8ce", + "image_id": 207224, + "image_name": "7137.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 533.469, + 939.748, + 1285.954, + 71.99699999999996 + ], + "priority": 4, + "parents": [ + 172276 + ], + "children": [], + "area": 501326.42581200006, + "iscrowd": 0, + "segmentation": [], + "text": "Japanese Orthopedic Association developed" + }, + { + "id": 172282, + "strid": "002c1dc2-7e94-4930-a449-8f730594a4bd", + "image_id": 207224, + "image_name": "7137.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 101.378, + 1011.847, + 1718.763, + 716.7079999999999 + ], + "priority": 5, + "parents": [ + 172276 + ], + "children": [], + "area": 102579.02516599999, + "iscrowd": 0, + "segmentation": [], + "text": "guidelines for the treatment of chronic low back pain,\ndemonstrating with high evidence the efficacy of treatment\nincluding exercise, CBT, and education with some journaling.\nTherefore, we developed the notebook including the three\ncontents above. “Ikiki in Japanese means “active”. The\npurpose of this study was to evaluate the efficacy of a cognitive\nbehavioral therapy (CBT)-based exercise facilitation method\nusing the “Ikiki Rehabilitation Notebook” for patients with\nchronic pain." + }, + { + "id": 172277, + "strid": "3078862f-b62c-4e8f-bcfc-3c227c71cc3d", + "image_id": 207224, + "image_name": "7137.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 102.093, + 1739.929, + 514.207, + 58.794000000000096 + ], + "priority": 6, + "parents": [ + 172293 + ], + "children": [ + 172283, + 172284 + ], + "area": 177634.57139700002, + "iscrowd": 0, + "segmentation": [], + "text": "Ethics committee:" + }, + { + "id": 172283, + "strid": "b8354344-9ff1-4814-aa7b-9d54877050eb", + "image_id": 207224, + "image_name": "7137.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 632.338, + 1739.726, + 1166.686, + 71.57500000000005 + ], + "priority": 7, + "parents": [ + 172277 + ], + "children": [], + "area": 1100094.859388, + "iscrowd": 0, + "segmentation": [], + "text": "The present study received ethical approval" + }, + { + "id": 172284, + "strid": "35df0981-0a58-4d47-8861-33d0bd6e00a3", + "image_id": 207224, + "image_name": "7137.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 101.463, + 1810.915, + 1619.021, + 77.981 + ], + "priority": 8, + "parents": [ + 172277 + ], + "children": [], + "area": 183740.86864499998, + "iscrowd": 0, + "segmentation": [], + "text": "from the Ethics Committee of Niigata University (No.2076)." + }, + { + "id": 172278, + "strid": "9182a7a9-1a18-4dc5-8394-dea58bbb7f43", + "image_id": 207224, + "image_name": "7137.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 98.499, + 1901.173, + 276.00199999999995, + 57.06400000000008 + ], + "priority": 9, + "parents": [ + 172293 + ], + "children": [ + 172286, + 172285 + ], + "area": 187263.63932699998, + "iscrowd": 0, + "segmentation": [], + "text": "Methods:" + }, + { + "id": 172285, + "strid": "f622d8a9-c4c7-4c68-a4a2-0c51f4eb6b7f", + "image_id": 207224, + "image_name": "7137.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 390.657, + 1899.283, + 1431.042, + 73.79099999999994 + ], + "priority": 10, + "parents": [ + 172278 + ], + "children": [], + "area": 741968.198931, + "iscrowd": 0, + "segmentation": [], + "text": "The subjects were 4 men and 6 women with chronic" + }, + { + "id": 172286, + "strid": "d03df239-8456-47a8-8bf8-7b6ee310505e", + "image_id": 207224, + "image_name": "7137.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 99.228, + 1972.941, + 1722.545, + 794.5240000000001 + ], + "priority": 11, + "parents": [ + 172278 + ], + "children": [], + "area": 195770.98954799998, + "iscrowd": 0, + "segmentation": [], + "text": "low back and/or lower extremity pain without specific lesions\n(Tab. 1). Indications for using the notebook were as follows: 1)\nNumeric Rating Scale (NRS) for pain >3, and 2) Brief Scale for\nPsychiatric Problems in Orthopedic Patients (Ref. 1) >15.\nPatients were asked to write in their notebooks (Fig.1, 2, 3)\ndaily regarding their emotion, mood, anxiety, and exercise\nroutine (Fig. 4) (muscle exertion, gait distance). Once every 2\nweeks, the patients returned to the clinic to go over the\nnotebook/journal. The evaluation contents were based on the\nInoue’s research (Ref. 2)" + }, + { + "id": 172279, + "strid": "06ca44eb-ae18-4d3d-a612-c3f4ce112d39", + "image_id": 207224, + "image_name": "7137.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 99.37, + 2780.581, + 233.72900000000004, + 55.998999999999796 + ], + "priority": 12, + "parents": [ + 172293 + ], + "children": [ + 172288, + 172287 + ], + "area": 276306.33397000004, + "iscrowd": 0, + "segmentation": [], + "text": "Results:" + }, + { + "id": 172287, + "strid": "4a4cf899-54a4-4de0-a7cb-d31d6b6181bf", + "image_id": 207224, + "image_name": "7137.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 386.466, + 2779.875, + 1433.94, + 73.44599999999991 + ], + "priority": 13, + "parents": [ + 172279 + ], + "children": [], + "area": 1074327.17175, + "iscrowd": 0, + "segmentation": [], + "text": "The NRS, PDAS and EQ-5D were improved" + }, + { + "id": 172288, + "strid": "8c8f0f5b-0cbf-4aea-bbd3-afa249630e3d", + "image_id": 207224, + "image_name": "7137.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 101.518, + 2853.453, + 1718.803, + 153.64199999999983 + ], + "priority": 14, + "parents": [ + 172279 + ], + "children": [], + "area": 289676.841654, + "iscrowd": 0, + "segmentation": [], + "text": "significantly (Tab. 1 & 2) 8 months after starting to use the\nnotebook, although the NRS improved slightly." + }, + { + "id": 172280, + "strid": "9d011cc8-2750-40a4-8bf2-eb55d0020cc3", + "image_id": 207224, + "image_name": "7137.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 100.33, + 3017.9, + 324.232, + 60.27300000000014 + ], + "priority": 15, + "parents": [ + 172293 + ], + "children": [ + 172267, + 172290, + 172265, + 172289, + 172268, + 172269, + 172271, + 172291, + 172266 + ], + "area": 302785.907, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion:" + }, + { + "id": 172289, + "strid": "70dfe561-36cd-4c71-bf48-575269e2f11d", + "image_id": 207224, + "image_name": "7137.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 447.551, + 3018.985, + 1373.39, + 70.42799999999988 + ], + "priority": 16, + "parents": [ + 172280 + ], + "children": [], + "area": 1351149.7557350001, + "iscrowd": 0, + "segmentation": [], + "text": "In the group programs with physical exercise and" + }, + { + "id": 172290, + "strid": "0e4c5d66-4cfd-434d-863e-720281a14415", + "image_id": 207224, + "image_name": "7137.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 102.58, + 3089.397, + 1718.232, + 317.7420000000002 + ], + "priority": 17, + "parents": [ + 172280 + ], + "children": [], + "area": 316910.34426, + "iscrowd": 0, + "segmentation": [], + "text": "CBT (weekly for nine weeks, Isession 2 hour) for patients with\nchronic pain, a number of measures (eg, pain intensity,\ndisability, catastrophizing thoughts) showed _ significant\nimprovements after intervention (Ref. 2)." + }, + { + "id": 172266, + "strid": 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"text": "Fig. 3 Dialy Record" + }, + { + "id": 172265, + "strid": "f7e1065a-39f0-45d8-96e8-c9f5f4695507", + "image_id": 207224, + "image_name": "7137.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 3734.699, + 1041.459, + 1759.0630000000006, + 939.1490000000001 + ], + "priority": 28, + "parents": [ + 172280 + ], + "children": [ + 172264 + ], + "area": 3889535.8858410004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 172264, + "strid": "8c4f4d27-88fe-40fd-8baf-d326a00541d0", + "image_id": 207224, + "image_name": "7137.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 3740.628, + 967.474, + 1694.342, + 64.11700000000008 + ], + "priority": 29, + "parents": [ + 172265 + ], + "children": [], + "area": 3618960.333672, + "iscrowd": 0, + "segmentation": [], + "text": "Table 2 Each parameter before and after usage of Notebook" + }, + { + "id": 172271, + "strid": "0b2dd645-eba3-4df1-8895-d4551b279757", + "image_id": 207224, + "image_name": 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In the future, cognitive approach\nshould be reinforced to improve the self-efficacy thoughts." + }, + { + "id": 172274, + "strid": "93f8f199-c97b-4bac-a859-5e500ddedb44", + "image_id": 207224, + "image_name": "7137.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3725.173, + 2563.681, + 339.7739999999999, + 53.47400000000016 + ], + "priority": 31, + "parents": [ + 172293 + ], + "children": [ + 172272, + 172292 + ], + "area": 9550155.241813, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion:" + }, + { + "id": 172292, + "strid": "3a206b87-a219-4949-b83e-b08b8c005e84", + "image_id": 207224, + "image_name": "7137.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4115.386, + 2561.684, + 1326.5470000000005, + 73.1210000000001 + ], + "priority": 32, + "parents": [ + 172274 + ], + "children": [], + "area": 10542318.470024003, + "iscrowd": 0, + "segmentation": [], + "text": "The ‘“Ikiiki Rehabilitation Notebook/Journal’”" + }, + { + "id": 172272, + "strid": "1dd3a538-a842-4ab7-b4c1-0fddfae39e47", + "image_id": 207224, + "image_name": "7137.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3721.971, + 2634.712, + 1719.5700000000002, + 224.26899999999978 + ], + "priority": 33, + "parents": [ + 172274 + ], + "children": [], + "area": 9806321.657352, + "iscrowd": 0, + "segmentation": [], + "text": "would be a valuable tool to educate patients about the cause and\ntreatment of pain and to actively facilitate the CBT-based\nexercise." + }, + { + "id": 172275, + "strid": "7b43dcb6-35b3-44a2-975f-db1c354113db", + "image_id": 207224, + "image_name": "7137.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3723.024, + 2882.234, + 335.09799999999996, + 55.016999999999825 + ], + "priority": 34, + "parents": [ + 172293 + ], + "children": [ + 172273 + ], + "area": 10730626.355616, + "iscrowd": 0, + "segmentation": [], + "text": "References:" + }, + { + "id": 172273, + "strid": "f1877dba-e66d-4ec3-aa6e-5eded82e6dce", + "image_id": 207224, + "image_name": "7137.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3723.273, + 2960.932, + 1720.1729999999998, + 464.0540000000001 + ], + "priority": 35, + "parents": [ + 172275 + ], + "children": [], + "area": 11024358.170436, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143683, + "strid": "b56edde0-2aff-4a9e-aa8a-bf43f5c3f7c7", + "image_id": 206083, + "image_name": "17388.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 63.15, + 82.07, + 344.82000000000005, + 344.82 + ], + "priority": -1, + "parents": [], + "children": [ + 143660, + 143658, + 143656, + 143681, + 143676, + 143679, + 143677, + 143657 + ], + "area": 5182.720499999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143656, + "strid": "7edbd068-d0e3-4d52-91cb-6a96a5358e89", + "image_id": 206083, + "image_name": "17388.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 646.651, + 99.492, + 2434.244, + 250.497 + ], + "priority": 1, + "parents": [ + 143683 + ], + "children": [], + "area": 64336.601292, + "iscrowd": 0, + "segmentation": [], + "text": "Simplified Form of Recurrent Neural Networks for\nPredicting Alzheimer Disease Progression" + }, + { + "id": 143657, + "strid": "d2f85ba3-c5bc-48d1-9528-4e6e0be2a4eb", + "image_id": 206083, + "image_name": "17388.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 855.89, + 417.771, + 1968.614, + 282.915 + ], + "priority": 2, + "parents": [ + 143683 + ], + "children": [], + "area": 357566.02119, + "iscrowd": 0, + "segmentation": [], + "text": "Sayantan Kumar,*; Aditi Gupta, PhD*; Inez Oh, PhD‘; Suzanne Schindler, MD,PhD*;\nAlbert M. Lai, PhD!; Philip R.O. Payne, PhD!\nInstitute for Informatics, Washington University School of Medicine, St. Louis, Missouri, USA\n\"Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA" + }, + { + "id": 143658, + "strid": "2debdd1f-f0a4-41c2-b658-690642732130", + "image_id": 206083, + "image_name": "17388.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1439.402, + 789.096, + 724.969, + 70.72900000000004 + ], + "priority": 3, + "parents": [ + 143683 + ], + "children": [ + 143668, + 143667, + 143663, + 143659, + 143661, + 143662 + ], + "area": 1135826.360592, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction and Data" + }, + { + "id": 143659, + "strid": "53ac1ab3-1970-41d9-87f6-265d50e078c3", + "image_id": 206083, + "image_name": "17388.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 71.019, + 897.194, + 1553.705, + 1002.3899999999999 + ], + "priority": 4, + "parents": [ + 143658 + ], + "children": [], + "area": 63717.820686, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143662, + "strid": "3739b916-f7d3-45b5-93d5-a110c0ae652d", + "image_id": 206083, + "image_name": "17388.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1689.879, + 887.886, + 1122.319, + 263.12699999999995 + ], + "priority": 5, + "parents": [ + 143658 + ], + "children": [], + "area": 1500419.9057939998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143663, + "strid": "606d7fac-74bc-4166-8f7a-4a370675b62a", + "image_id": 206083, + "image_name": "17388.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1695.249, + 1181.443, + 1107.999, + 125.29899999999998 + ], + "priority": 6, + "parents": [ + 143658 + ], + "children": [], + "area": 2002840.064307, + "iscrowd": 0, + "segmentation": [], + "text": "Longitudinal data from 1193 patients with 3676\nvisits (mean = 3.08 +/- 1.15)" + }, + { + "id": 143661, + "strid": "e7154352-3ba5-4dd0-8658-3e5244d684ec", + "image_id": 206083, + "image_name": "17388.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2826.518, + 878.936, + 701.6729999999998, + 433.17600000000004 + ], + "priority": 7, + "parents": [ + 143658 + ], + "children": [ + 143665 + ], + "area": 2484328.424848, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143665, + "strid": "db023cce-0cd9-448b-9761-767fbe3ce3c5", + "image_id": 206083, + "image_name": "17388.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2826.518, + 1315.692, + 699.8829999999998, + 85.9190000000001 + ], + "priority": 8, + "parents": [ + 143661 + ], + "children": [], + "area": 3718827.120456, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1: Distribution of number of\nmonths between 2 successive visits." + }, + { + "id": 143668, + "strid": "655f7386-7330-4d17-b07a-e1424c73913b", + "image_id": 206083, + "image_name": "17388.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1677.349, + 1466.05, + 963.0109999999997, + 488.66499999999996 + ], + "priority": 9, + "parents": [ + 143658 + ], + "children": [ + 143664 + ], + "area": 2459077.50145, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143664, + "strid": "e95dcb8e-f2ec-4a1f-a04b-55bce52f77b4", + "image_id": 206083, + "image_name": "17388.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1686.299, + 1365.811, + 925.4210000000003, + 94.86899999999991 + ], + "priority": 10, + "parents": [ + 143668 + ], + "children": [], + "area": 2303165.723489, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1: List of features used. Clinical diagnosis refers to\nanalytical grouping in Table 2" + }, + { + "id": 143667, + "strid": "db8cba97-16dc-4e14-8e3b-9c0e2a928c67", + "image_id": 206083, + "image_name": "17388.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2670.789, + 1535.86, + 869.9320000000002, + 420.64599999999996 + ], + "priority": 11, + "parents": [ + 143658 + ], + "children": [ + 143666 + ], + "area": 4101957.99354, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143666, + "strid": "bfad2ef8-a952-433d-9f82-8603074f7ab2", + "image_id": 206083, + "image_name": "17388.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2676.159, + 1440.99, + 794.752, + 89.49900000000002 + ], + "priority": 12, + "parents": [ + 143667 + ], + "children": [], + "area": 3856318.35741, + "iscrowd": 0, + "segmentation": [], + "text": "Table 2: Clinical diagnosis determined by\nClinical Dementia Rating (CDR) score*." + }, + { + "id": 143660, + "strid": "0fb7210d-24ba-4050-876f-709dffc8f1fa", + "image_id": 206083, + "image_name": "17388.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1662.313, + 2019.871, + 288.1869999999999, + 75.17900000000009 + ], + "priority": 13, + "parents": [ + 143683 + ], + "children": [ + 143675, + 143673, + 143669, + 143670 + ], + "area": 3357657.8216230003, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 143669, + "strid": "dcafcfff-75f7-4db7-9d90-ae81a82dd48a", + "image_id": 206083, + "image_name": "17388.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 72.332, + 2149.823, + 1563.2510000000002, + 1017.3070000000002 + ], + "priority": 14, + "parents": [ + 143660 + ], + "children": [], + "area": 155500.99723599997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143670, + "strid": "77c05345-84e1-451a-85b9-7b31eda7d9cb", + "image_id": 206083, + "image_name": "17388.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1729.146, + 2123.505, + 705.7, + 759.6289999999999 + ], + "priority": 15, + "parents": [ + 143660 + ], + "children": [ + 143671 + ], + "area": 3671850.17673, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143671, + "strid": "816256e9-dbae-4343-8044-c4a11e9f805c", + "image_id": 206083, + "image_name": "17388.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1729.146, + 2898.543, + 705.7, + 278.8899999999999 + ], + "priority": 16, + "parents": [ + 143670 + ], + "children": [], + "area": 5012004.034278, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2: MinimalRNN architecture and its update\nequations. num, and cat, represent the\ncontinuous and categorical variables at time t\nrespectively. The model takes its previous state\nh,-, and the encoded input z, and outputs a\nweighted average of both depending on the forget\n\ngate f, ." + }, + { + "id": 143675, + "strid": "992fd733-6222-4171-88f7-5968bdbb9754", + "image_id": 206083, + "image_name": "17388.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2613.583, + 2118.883, + 805.8539999999998, + 288.1350000000002 + ], + "priority": 17, + "parents": [ + 143660 + ], + "children": [ + 143674 + ], + "area": 5537876.587789, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143674, + "strid": "74d202be-165e-416b-ab27-375a2250f1ec", + "image_id": 206083, + "image_name": "17388.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2481.071, + 2411.64, + 1033.897, + 123.26600000000008 + ], + "priority": 18, + "parents": [ + 143675 + ], + "children": [], + "area": 5983450.066439999, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3: Model-filling imputes missing values using model predictions.\nFor example, both features A and B at time ¢ = 1 were used by the model to\npredict both input features at time ¢ = 2." + }, + { + "id": 143673, + "strid": "e34c1135-cfca-4e66-aa0b-04fee5b76fca", + "image_id": 206083, + "image_name": "17388.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2632.073, + 2539.529, + 731.8939999999998, + 508.47400000000016 + ], + "priority": 19, + "parents": [ + 143660 + ], + "children": [ + 143672 + ], + "area": 6684225.713617, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143672, + "strid": "d69cd648-c214-4e9c-9a77-9f94aa43aee9", + "image_id": 206083, + "image_name": "17388.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2481.071, + 3061.871, + 1043.1419999999998, + 124.80699999999979 + ], + "priority": 20, + "parents": [ + 143673 + ], + "children": [], + "area": 7596719.3438409995, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 4: Predicting future timepoints (x,, Xs, X¢, etc.) given three initial\ntimepoints (x;, x2, and x3). X3,X, and x, were used as inputs (timepoints\n4, 5 and 6 to predict further into the future." + }, + { + "id": 143679, + "strid": "45a088f5-c04e-41de-8a7b-f1b964233fc0", + "image_id": 206083, + "image_name": "17388.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 88.382, + 3822.527, + 1203.315, + 520.9470000000001 + ], + "priority": 21, + "parents": [ + 143683 + ], + "children": [ + 143680 + ], + "area": 337842.581314, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143680, + "strid": "11cc18d2-5a08-432c-ba18-711b957bbe40", + "image_id": 206083, + "image_name": "17388.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 84.713, + 3358.444, + 1212.487, + 461.46900000000005 + ], + "priority": 22, + "parents": [ + 143679 + ], + "children": [], + "area": 284503.86657199997, + "iscrowd": 0, + "segmentation": [], + "text": "Table 3: Performance of MinimalRNN and LSTM for both model filling\nand linear filling, averaged across 10 test sets. For clinical diagnosis,\nhigher MAUROC values indicate better performance. For Boston Naming\nTest and Logical Memory, lower MAE indicates better performance. The 1st\nand 2\"4 best model for each for the metrics are highlighted in red and\nblue respectively. The last row (5) shows the difference between the 1‘\nand the 24 ranked models for each metric. MinRNN-MF =\nMinimalRNN with model filling, MinRNN-LF = MinimalRNN with linear\nfilling, LSTM-MF = LSTM with model filling, LSTM-LF = LSTM with\nlinear filling." + }, + { + "id": 143677, + "strid": "bd07d59e-e25a-40ba-8005-dec2bade187f", + "image_id": 206083, + "image_name": "17388.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1326.549, + 3523.533, + 660.356, + 471.4209999999998 + ], + "priority": 23, + "parents": [ + 143683 + ], + "children": [ + 143678 + ], + "area": 4674139.1776169995, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143678, + "strid": "6e2f7e19-af0a-4d8f-a563-269a7c98c80e", + "image_id": 206083, + "image_name": "17388.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1357.733, + 3998.622, + 621.835, + 152.24900000000025 + ], + "priority": 24, + "parents": [ + 143677 + ], + "children": [], + "area": 5429061.043926, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 5: Training time for all the 4\nmodels. MinRNN had a ~1.6X faster\nmodel training time than LSTM." + }, + { + "id": 143676, + "strid": "f032fd9c-915b-42c5-9210-ff61a6bba263", + "image_id": 206083, + "image_name": "17388.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2013.686, + 3362.846, + 1520.2859999999998, + 965.587 + ], + "priority": 25, + "parents": [ + 143683 + ], + "children": [], + "area": 6771715.910356, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143681, + "strid": "c523416f-8301-4f31-abce-caa58935acd2", + "image_id": 206083, + "image_name": "17388.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1624.772, + 4409.164, + 355.2750000000001, + 73.6869999999999 + ], + "priority": 26, + "parents": [ + 143683 + ], + "children": [ + 143682 + ], + "area": 7163886.210607999, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 143682, + "strid": "a46082af-9e00-4ab2-bc07-4f727235fdfa", + "image_id": 206083, + "image_name": "17388.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 79.986, + 4522.326, + 3410.636, + 239.48099999999977 + ], + "priority": 27, + "parents": [ + 143681 + ], + "children": [], + "area": 361722.767436, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 87967, + "strid": "f1107f60-8615-44ce-b480-2b415ee21d7f", + "image_id": 203916, + "image_name": "121156.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 66.19, + 656.69, + 52.010000000000005, + 176.81999999999994 + ], + "priority": -1, + "parents": [], + "children": [ + 87954, + 87953, + 87952, + 87966, + 87951 + ], + "area": 43466.3111, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 87951, + "strid": "48832113-5139-4cf9-b6c3-e52a60660381", + "image_id": 203916, + "image_name": "121156.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 111.496, + 100.424, + 3307.206, + 489.09400000000005 + ], + "priority": 1, + "parents": [ + 87967 + ], + "children": [], + "area": 11196.874304, + "iscrowd": 0, + "segmentation": [], + "text": "Using high-throughput technologies\nto improve stress tolerance SE\noe Ti a ota 7S\n\nOO" + }, + { + "id": 87952, + "strid": "c3f8f84d-6e95-4b33-80de-ad840dad2724", + "image_id": 203916, + "image_name": "121156.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 139.444, + 612.809, + 3269.942, + 451.8299999999999 + ], + "priority": 2, + "parents": [ + 87967 + ], + "children": [], + "area": 85452.538196, + "iscrowd": 0, + "segmentation": [], + "text": "Francisco Garcia-Garcia!?, Paula Fernandez?, Ana Conesa?, Norma Paniego?2, Ruth Heinz?, Lucila Peluffo4,\nVeronica Lia*, Laura de la Canal, Karina F. 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Advances in sunflower genomics\nhave greatly enhanced the development and application of new tools for crop improvement, and promoted the expansion of\nsunflower-uses to new markets like biofuels,~biolubricants and biopharma. 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Draviam*\n\n# Department of Genetics) University of Cambridge, Downing Street, Cambridge-CB2 3EH (UK)" + }, + { + "id": 81324, + "strid": "e6487c50-7a7c-42b0-b278-3241d1e3161a", + "image_id": 203665, + "image_name": "120698.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 36.7, + 296.737, + 173.707, + 36.233000000000004 + ], + "priority": 3, + "parents": [ + 81359 + ], + "children": [ + 81335 + ], + "area": 10890.247900000002, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 81335, + "strid": "7470dba3-973b-47cb-a48a-8b56ca1bd4b2", + "image_id": 203665, + "image_name": "120698.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 34.749, + 372.428, + 2269.603, + 122.73199999999997 + ], + "priority": 4, + "parents": [ + 81324 + ], + "children": [], + "area": 12941.500572, + "iscrowd": 0, + "segmentation": [], + "text": "Chromosome instability (CIN) is a halmark of cancers. How chromosomes attach to microtubules is not fully understood and hence our-goal is to study\nproteins that are essential for the early event-of chromosome-microtubules (KT-MT)-capture. Our studies confirm that the phosphatase PP2A plays\nan important role in chromosome congression. Here we present data to show how’the phosphatase controls KT-MT attachments." + }, + { + "id": 81325, + "strid": "fa3d715a-7dd3-4fed-b3ef-766fdedafd7e", + "image_id": 203665, + "image_name": "120698.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 31.372, + 536.516, + 1224.474, + 43.692999999999984 + ], + "priority": 5, + "parents": [ + 81359 + ], + "children": [ + 81338, + 81336, + 81357, + 81339, + 81354 + ], + "area": 16831.579952, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction: protein phosphatases and chromosome capture" + }, + { + "id": 81336, + "strid": "ae040fbd-fbbf-4e66-8af6-22c672ba9262", + "image_id": 203665, + "image_name": "120698.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 29.66, + 611.445, + 502.16, + 548.8539999999999 + ], + "priority": 6, + "parents": [ + 81325 + ], + "children": [], + "area": 18135.458700000003, + "iscrowd": 0, + "segmentation": [], + "text": "Background:\n\nDuring mitosis, chromosomes are captured) by\nmicrotubules of the mitotic spindle and\\ accurately\nsegregated into two daughter cells. In the past years,\nseveral proteins have been identified ‘as important\nmembers of the segregation’ process’, yet the\nunderlying mechanism is far from being completely\nunderstood.\n\nCounteraction between phosphatases and kinases is a\ncrucial event in cellular mechanism. PP1 and PP2A\nphosphatases have\\been shown to regulate the\nsegregation process at the kinetochore by\ncounteracting ‘a major mitotic kinase: Aurora B°.\n\nChromosomes first attach to the lateral surface of\nmicrotubules and then attach to the ends of\nmicrotubules, the process termed as_ end-on\neonversion*®.\n\nOur laboratory recently visualised the end-on conver-" + }, + { + "id": 81338, + "strid": "5188817e-fbbb-4ee5-b240-c37e95acd338", + "image_id": 203665, + "image_name": "120698.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 547.92, + 613.273, + 456.264, + 97.52200000000005 + ], + "priority": 7, + "parents": [ + 81325 + ], + "children": [], + "area": 336024.54216, + "iscrowd": 0, + "segmentation": [], + "text": "-sion process in human cells using time-lapse\nmicroscopy and developed an assay for\nanalysing KT-MT attachment status in living and\nfixed cells®." + }, + { + "id": 81357, + "strid": "44e19858-35b6-4d4d-8c1a-31b163b05564", + "image_id": 203665, + "image_name": "120698.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 556.901, + 820.181, + 434.793, + 331.0930000000001 + ], + "priority": 8, + "parents": [ + 81325 + ], + "children": [ + 81356 + ], + "area": 456759.619081, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 81356, + "strid": "94fd8c47-0b82-4bd7-906f-2765a7402e39", + "image_id": 203665, + "image_name": "120698.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 548.156, + 751.464, + 457.283, + 47.476999999999975 + ], + "priority": 9, + "parents": [ + 81357 + ], + "children": [], + "area": 411919.500384, + "iscrowd": 0, + "segmentation": [], + "text": "PP1 and PP2A known recruiters at the kineto-\nchore:" + }, + { + "id": 81354, + "strid": "d771f431-3f91-4d35-bff9-063eca4b9a4b", + "image_id": 203665, + "image_name": "120698.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1026.678, + 656.509, + 572.2279999999998, + 287.36300000000006 + ], + "priority": 10, + "parents": [ + 81325 + ], + "children": [ + 81355 + ], + "area": 674023.3471020001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 81355, + "strid": "cbba7ec9-ee88-448b-92e8-b95652363677", + "image_id": 203665, + "image_name": "120698.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1027.928, + 611.53, + 404.808, + 23.739000000000033 + ], + "priority": 11, + "parents": [ + 81354 + ], + "children": [], + "area": 628608.80984, + "iscrowd": 0, + "segmentation": [], + "text": "BubR’1 recruits PP2A to the kinetochore:" + }, + { + "id": 81339, + "strid": "d92c5f06-cf58-4284-b975-d8ce3649519a", + "image_id": 203665, + "image_name": "120698.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1023.92, + 965.214, + 546.4879999999999, + 174.14700000000005 + ], + "priority": 12, + "parents": [ + 81325 + ], + "children": [], + "area": 988301.91888, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 81326, + "strid": "31031388-bb7c-4603-907f-9f55d1617b1a", + "image_id": 203665, + "image_name": "120698.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1649.853, + 536.031, + 425.00599999999986, + 37.153999999999996 + ], + "priority": 13, + "parents": [ + 81359 + ], + "children": [ + 81340 + ], + "area": 884372.353443, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 81340, + "strid": "6b58b36e-b868-40ab-a4fa-16ed3209e9d8", + "image_id": 203665, + "image_name": "120698.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1654.164, + 633.507, + 600.3909999999998, + 172.48799999999994 + ], + "priority": 14, + "parents": [ + 81326 + ], + "children": [], + "area": 1047924.473148, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 81327, + "strid": "a5a2f76d-8abb-4d35-b88d-807dc6ec603d", + "image_id": 203665, + "image_name": "120698.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1649.853, + 859.543, + 442.22400000000016, + 35.341999999999985 + ], + "priority": 15, + "parents": [ + 81359 + ], + "children": [ + 81337 + ], + "area": 1418119.597179, + "iscrowd": 0, + "segmentation": [], + "text": "Relevance of the work" + }, + { + "id": 81337, + "strid": "95bbce7e-9e87-45c2-a0ab-7aca7590f12d", + "image_id": 203665, + "image_name": "120698.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1647.55, + 945.672, + 657.8059999999998, + 199.0619999999999 + ], + "priority": 16, + "parents": [ + 81327 + ], + "children": [], + "area": 1558041.9036, + "iscrowd": 0, + "segmentation": [], + "text": "An error in chromosome capture can lead to aneuploidy. This is a\ncondition where a daughter cell presents a highersor lower amount of\ngenetic material in comparison to a normal cell. Aneuploidy is the\nhallmark of most aggressive cancers®.\n\nUnraveling the molecular mechanism,undeérlying chromosome capture,\ncongression and segregation iis crucial for understanding disease\ncondition and design molecular'target to fight them." + }, + { + "id": 81329, + "strid": "038106c5-e2c6-40a3-8b2d-d8b8c1fef17b", + "image_id": 203665, + "image_name": "120698.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 29.554, + 1196.257, + 186.746, + 34.07300000000009 + ], + "priority": 17, + "parents": [ + 81359 + ], + "children": [ + 81352, + 81341, + 81358 + ], + "area": 35354.179378, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 81358, + "strid": "08f3b097-0242-4a70-b710-a40fd7bc7323", + "image_id": 203665, + "image_name": "120698.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 32.005, + 1257.46, + 269.219, + 121.05799999999999 + ], + "priority": 18, + "parents": [ + 81329 + ], + "children": [], + "area": 40245.007300000005, + "iscrowd": 0, + "segmentation": [], + "text": "Cell lines:\n\nHela FRT/TO\nHela FRT/TO Venus-BubR1 wT?\nHela FRT/TO Venus-BubR1 4660-6857" + }, + { + "id": 81352, + "strid": "3d93d0bb-ebea-45b3-a9fc-12cb9f64f0d6", + "image_id": 203665, + "image_name": "120698.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 340.754, + 1208.746, + 356.081, + 184.91200000000003 + ], + "priority": 19, + "parents": [ + 81329 + ], + "children": [], + "area": 411885.03448400006, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 81341, + "strid": "31138b6b-88f3-4d67-8c8e-611d45703d21", + "image_id": 203665, + "image_name": "120698.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 743.172, + 1203.497, + 306.7449999999999, + 177.46499999999992 + ], + "priority": 20, + "parents": [ + 81329 + ], + "children": [], + "area": 894405.2724840001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 81328, + "strid": "4d7fe96e-ca27-4c48-b16f-41863f15bbba", 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This could it be\npossible by counteracting motor function." + }, + { + "id": 81334, + "strid": "6c9e30d0-41ee-4677-a096-8cd46a6209b3", + "image_id": 203665, + "image_name": "120698.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1363.137, + 2620.353, + 340.442, + 35.58899999999994 + ], + "priority": 33, + "parents": [ + 81359 + ], + "children": [ + 81342 + ], + "area": 3571900.127361, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 81342, + "strid": "7d48e881-22b9-4832-a51a-d9780a04731c", + "image_id": 203665, + "image_name": "120698.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1360.449, + 2719.61, + 944.2339999999999, + 151.75199999999995 + ], + "priority": 34, + "parents": [ + 81334 + ], + "children": [], + "area": 3699890.70489, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 81332, + "strid": "24e8b770-752a-4a90-8d49-73ebd7c30bae", + "image_id": 203665, + "image_name": "120698.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 30.713, + 2960.011, + 309.769, + 41.789000000000215 + ], + "priority": 35, + "parents": [ + 81359 + ], + "children": [], + "area": 90910.817843, + "iscrowd": 0, + "segmentation": [], + "text": "Funding bodies" + }, + { + "id": 81333, + "strid": "c9560d42-2e9c-4d60-969b-edb248af2e16", + "image_id": 203665, + "image_name": "120698.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1009.769, + 2959.348, + 222.875, + 35.81899999999996 + ], + "priority": 36, + "parents": [ + 81359 + ], + "children": [ + 81344 + ], + "area": 2988257.870612, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 81344, + "strid": "dfbe950f-31b7-431d-aea4-ff23929f4a8c", + "image_id": 203665, + "image_name": "120698.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1005.157, + 3020.705, + 1291.0949999999998, + 258.942 + ], + "priority": 37, + "parents": [ + 81333 + ], + "children": [], + "area": 3036282.7756850002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 109171, + "strid": "d7901b4e-5a9b-4424-8895-5815b453593f", + "image_id": 204735, + "image_name": "12957.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 2328.61, + 240.93, + 247.6500000000001, + 237.75 + ], + "priority": -1, + "parents": [], + "children": [ + 109163, + 109168, + 109165, + 109162, + 109161, + 109164, + 109166, + 109167, + 109170, + 109169 + ], + "area": 561032.0073, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 109161, + "strid": "2407ef64-7922-43da-abfb-74a0f05de1c7", + "image_id": 204735, + "image_name": "12957.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 166.617, + 141.745, + 2038.8460000000002, + 448.369 + ], + "priority": 1, + "parents": [ + 109171 + ], + "children": [], + "area": 23617.126665, + "iscrowd": 0, + "segmentation": [], + "text": "Compute Tic\n\nfor ELIXIR-ES/INB ei" + }, + { + "id": 109163, + "strid": "d2f89389-7b2c-4ace-a961-80b1960fd0e3", + "image_id": 204735, + "image_name": "12957.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 59.599, + 796.034, + 3167.699, + 444.69500000000005 + ], + "priority": 2, + "parents": [ + 109171 + ], + "children": [], + "area": 47442.830365999995, + "iscrowd": 0, + "segmentation": [], + "text": "ELIXIR-ES node integrates a new cloud platform service into the ELIXIR Compute Platform.\n\nThe new infrastructure, called STARLIFE, is hosted at the Barcelona Supercomputing Center (BSC) and it is mean to provide support for\nhigh performance computing (HPC) applications as well as cloud-based services. STARLIFE accounts for 2,640 cores with a total of 7.5PB\nof storage - 2PB on shared disk, 1PB of storage for fast data retrieval, and 4.5 PB on tape. Part of these resources are going to be dedicated\nto the European Genome-phenome Archive (EGA), while others are going to be offered as a PaaS-like (Platform as a Service) for the\n\nELIXIR-ES Compute platform." + }, + { + "id": 109162, + "strid": "9d9ec5f0-9386-4c0d-8468-4448bf729d7c", + "image_id": 204735, + "image_name": "12957.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 44.225, + 1338.84, + 3218.082, + 1823.5469999999998 + ], + "priority": 3, + "parents": [ + 109171 + ], + "children": [], + "area": 59210.199, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 109168, + "strid": "80ee7d5a-9800-4d0f-b1f0-d49b0e40f593", + "image_id": 204735, + "image_name": "12957.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 50.649, + 3284.267, + 1022.254, + 216.16100000000006 + ], + "priority": 4, + "parents": [ + 109171 + ], + "children": [], + "area": 166344.839283, + "iscrowd": 0, + "segmentation": [], + "text": "‘® OpenNebula is the chosen cloud middleware, yet\nthe PaaS is compatible with OCCI*? (Open Cloud\n\nComputing Interface) compliance clouds, like\nOpenStack or AWS." + }, + { + "id": 109164, + "strid": "dc22f9b2-00ca-46c7-83f5-2945ae10c3b5", + "image_id": 204735, + "image_name": "12957.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 32.806, + 3549.011, + 1033.985, + 342.37300000000005 + ], + "priority": 5, + "parents": [ + 109171 + ], + "children": [], + "area": 116428.854866, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 109169, + "strid": "6c8f754d-eeaa-418b-8b98-069f22cbc075", + "image_id": 204735, + "image_name": "12957.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1138.964, + 3279.942, + 1025.746, + 327.30499999999984 + ], + "priority": 6, + "parents": [ + 109171 + ], + "children": [], + "area": 3735735.8600879996, + "iscrowd": 0, + "segmentation": [], + "text": "Ne The infrastructure is going to support both, long\nrunning services and the automatic deployment of\npre-packaged applications. These customized\ncompute-on-demand applications are going to be\nbanked on a repository of images or containerized\napplications." + }, + { + "id": 109167, + "strid": "b55dc37a-62a2-47ec-a930-a6dcef356141", + "image_id": 204735, + "image_name": "12957.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1137.651, + 3622.717, + 1023.059, + 492.25599999999986 + ], + "priority": 7, + "parents": [ + 109171 + ], + "children": [], + "area": 4121387.6177670006, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 109170, + "strid": "058328ed-6eee-4e1b-90cd-8deb17064b26", + "image_id": 204735, + "image_name": "12957.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2228.328, + 3279.014, + 1018.77, + 106.63400000000001 + ], + "priority": 8, + "parents": [ + 109171 + ], + "children": [], + "area": 7306718.708592, + "iscrowd": 0, + "segmentation": [], + "text": "Ne ELIXIR relying services like a EGA-external cloud\nare going to be included in the services catalog." + }, + { + "id": 109165, + "strid": "7d98b64f-e87f-4b02-b627-1595ca33764e", + "image_id": 204735, + "image_name": "12957.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2208.196, + 3456.017, + 1058.176, + 338.06899999999996 + ], + "priority": 9, + "parents": [ + 109171 + ], + "children": [], + "area": 7631562.915332, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 109166, + "strid": "f3995eec-2009-41f1-a97a-1c2cd5ed4a53", + "image_id": 204735, + "image_name": "12957.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2385.94, + 3884.306, + 827.3020000000001, + 230.54999999999973 + ], + "priority": 10, + "parents": [ + 109171 + ], + "children": [], + "area": 9267721.057640001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 116260, + "strid": "533d4ef6-df1e-42e7-b705-527119b6e6af", + "image_id": 205019, + "image_name": "13804.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 291.78, + 103.75, + 376.47, + 150.59 + ], + "priority": -1, + "parents": [], + "children": [ + 116258, + 116252, + 116250, + 116253, + 116255, + 116249 + ], + "area": 30272.174999999996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 116249, + "strid": "b70d5ac1-3fc7-4bea-8076-162cd1da36a7", + "image_id": 205019, + "image_name": "13804.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 950.903, + 116.968, + 2898.9169999999995, + 223.827 + ], + "priority": 1, + "parents": [ + 116260 + ], + "children": [], + "area": 111225.222104, + "iscrowd": 0, + "segmentation": [], + "text": "Real Time Facial Expression and Speech Emotion Recognition : EMOTII\nHumaid Saif Saeed Alasli Alshamsi\n\nand Science" + }, + { + "id": 116250, + "strid": "78ab8bbe-7d40-43b4-972a-f5640821cdad", + "image_id": 205019, + "image_name": "13804.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1896.751, + 557.401, + 1000.0000000000002, + 104.69299999999998 + ], + "priority": 2, + "parents": [ + 116260 + ], + "children": [], + "area": 1057250.9041509998, + "iscrowd": 0, + "segmentation": [], + "text": "Veton Z. 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Dikkers?, A.M. Boot Brouwer\" om\n'Atdeling Neurologie, 7Afdeling oa Afdeling Kindergeneeskunde?, Universitair Medisch Centrum Groningen\n») Groningen i" + }, + { + "id": 19585, + "strid": "09c837ee-973b-4885-953f-57c791c0a015", + "image_id": 201273, + "image_name": "116860.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 57.439, + 212.262, + 93.62200000000001, + 18.144000000000005 + ], + "priority": 3, + "parents": [ + 19603 + ], + "children": [ + 19589 + ], + "area": 12192.117018, + "iscrowd": 0, + "segmentation": [], + "text": "Introductie" + }, + { + "id": 19589, + "strid": "f188eb1e-933b-4a5a-9fdd-3d3fe8c9c8f3", + "image_id": 201273, + "image_name": "116860.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 56.876, + 259.389, + 225.87699999999998, + 195.151 + ], + "priority": 4, + "parents": [ + 19585 + ], + "children": [], + "area": 14753.008764, + "iscrowd": 0, + "segmentation": [], + "text": "Uitval van de ny facialis bij kinderen\nheeft een uitgebreide differentiaal\ndiagnose. Wij beschrijven rie\nkinder de zich presenteerden voor\nhet\\4* levensjaar_met een perifere\nzichtsverlamming, aanvankeli\néenzijdig, later bilateraal. Zij bleken\nallen de ziekte van Van Buchem te\nhebben, een ziekte die tot nu toe\nwereldwijd bij slechts\\~ circa 25\npatignten werd beschreven." + }, + { + "id": 19586, + "strid": "e6a847fd-e914-478b-9cc4-7f28dcbd9212", + "image_id": 201273, + "image_name": "116860.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 55.625, + 459.462, + 48.495000000000005, + 17.223000000000013 + ], + "priority": 5, + "parents": [ + 19603 + ], + "children": [ + 19593, + 19592 + ], + "area": 25557.57375, + "iscrowd": 0, + "segmentation": [], + "text": "Casus" + }, + { + "id": 19592, + "strid": "dd647378-ec69-40b7-809b-64483cc633fc", + "image_id": 201273, + "image_name": "116860.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 54.265, + 506.266, + 226.832, + 283.58600000000007 + ], + "priority": 6, + "parents": [ + 19586 + ], + "children": [], + "area": 27472.52449, + "iscrowd": 0, + "segmentation": [], + "text": ". iént 1, een 4-jarige Gna patiént\n2, 2ijn\\G-jarige zus (consanguine\nou i en patiént 3, een 4jaar oud\nje, hadden vanaf de leeftijd vz\nresp. 9 maanden, 2 jaar en sre po\n\npartum meerdere spent\n\nperifere n. facialisuitval rechts of links.\nDe duur van de eee enige\nweken tot nee trad steeds\nslechts gedeeltelk” herstel op.\nInmiddels hee 2ij alle drie een\npermanente bilaterale uitval varigrend\nvan House:Brackmann gr. IV tot gr. VI.\nVardeg@bi al dhe elders Het\n\ngehoi rvees vastgesteld (conductief\n‘at. 1 en 2 en gemengd bij pat. 3).\n\net" + }, + { + "id": 19593, + "strid": "a49c08ff-c803-4ae1-86b7-b0b7860dd78d", + "image_id": 201273, + "image_name": "116860.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 303.611, + 214.102, + 241.96500000000003, + 101.76500000000001 + ], + "priority": 7, + "parents": [ + 19586 + ], + "children": [ + 19597 + ], + "area": 65003.722322, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 19597, + "strid": "d9512261-075e-407b-bec2-88c8918f17fc", + "image_id": 201273, + "image_name": "116860.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 305.723, + 321.349, + 231.96600000000007, + 59.29699999999997 + ], + "priority": 8, + "parents": [ + 19593 + ], + "children": [], + "area": 98243.780327, + "iscrowd": 0, + "segmentation": [], + "text": "Figuur 1. Gelaatsfoto's van patiént 1 (links) en\npaint 2 recht), in rust (A, C) en tidens z0\nPaclg nog ctinipen wn ope\n(8, D).*" + }, + { + "id": 19587, + "strid": "c251a329-15e8-49ca-9051-6c26efbc5499", + "image_id": 201273, + "image_name": "116860.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 301.177, + 400.244, + 77.68, + 16.31400000000002 + ], + "priority": 9, + "parents": [ + 19603 + ], + "children": [ + 19591, + 19595, + 19594, + 19602, + 19601, + 19596 + ], + "area": 120544.28718800002, + "iscrowd": 0, + "segmentation": [], + "text": "Discussie" + }, + { + "id": 19591, + "strid": "f0d10b53-2462-4293-a8d8-dd09a8fad8b1", + "image_id": 201273, + "image_name": "116860.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 301.531, + 448.488, + 246.45099999999996, + 159.62899999999996 + ], + "priority": 10, + "parents": [ + 19587 + ], + "children": [], + "area": 135233.035128, + "iscrowd": 0, + "segmentation": [], + "text": "De ziekte varr Van Buchem, ofwel\nhyperostosis corticalis generalisata, is een\nautosomaal recessief overervende bot-\nsandoening, Verminderde functie van hi\nGP contin lat to ongereride\n\neoblastactviteit en daarmeé.» tot\nongebreidelde groei van botweefsel. De\noorzaak is een homozygote S2-kb deletie\nop chromosoom 17q. >." + }, + { + "id": 19602, + "strid": "e45fe754-171d-47ba-85b5-242f8c801c56", + "image_id": 201273, + "image_name": "116860.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 300.667, + 613.246, + 247.12600000000003, + 173.31499999999994 + ], + "priority": 11, + "parents": [ + 19587 + ], + "children": [], + "area": 184382.83508199998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 19594, + "strid": "d31df6b1-5296-49c1-b8ef-1378e0802812", + "image_id": 201273, + "image_name": "116860.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 582.786, + 520.546, + 191.60400000000004, + 145.88699999999994 + ], + "priority": 12, + "parents": [ + 19587 + ], + "children": [ + 19598 + ], + "area": 303366.921156, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 19598, + "strid": "5ae839d9-677f-4eb2-9b4e-ccc7b42ea326", + "image_id": 201273, + "image_name": "116860.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 578.773, + 676.322, + 193.39199999999994, + 72.72199999999998 + ], + "priority": 13, + "parents": [ + 19594 + ], + "children": [], + "area": 391436.91290600004, + "iscrowd": 0, + "segmentation": [], + "text": "Figuur 4 —Fenotype van een\nvolwassen patiént met de ziekte\nvan Van Buchem, Opvallend “a\nhyperostosis van de mandibul e\nbilaterale uitval van de n. facial" + }, + { + "id": 19601, + "strid": "b4a30068-58b8-46e6-8960-9953d196c999", + "image_id": 201273, + "image_name": "116860.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 579.575, + 769.283, + 193.976, + 25.184999999999945 + ], + "priority": 14, + "parents": [ + 19587 + ], + "children": [], + "area": 445857.19472500007, + "iscrowd": 0, + "segmentation": [], + "text": "“Be Kates ven Appar 7 on SNS pee afeaeatt\namet toedtammi van bodghed" + }, + { + "id": 19596, + "strid": "961bce36-db05-443f-84cf-9211e3188ce8", + "image_id": 201273, + "image_name": "116860.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 82.638, + 807.02, + 344.7919999999999, + 206.87799999999993 + ], + "priority": 15, + "parents": [ + 19587 + ], + "children": [ + 19600 + ], + "area": 66690.51876, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 19600, + "strid": "05799c9a-0039-456d-a117-5857c8705b2c", + "image_id": 201273, + "image_name": "116860.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 85.134, + 1016.371, + 340.975, + 59.372999999999934 + ], + "priority": 16, + "parents": [ + 19596 + ], + "children": [], + "area": 86527.728714, + "iscrowd": 0, + "segmentation": [], + "text": "Figuur 2. Beeldvorming van de schedel. CT-cerebrum, transversale\ncies hoop nt rey, lt 9 ops\nfi Inks) met forse vetdling von de shed Ter serge\n\nson CT-serehrumvan peperonde keeRildgenoot (rechis). ee" + }, + { + "id": 19595, + "strid": "bb7c3b2a-6783-4c03-a96e-2ff0d8d98870", + "image_id": 201273, + "image_name": "116860.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 460.629, + 806.755, + 272.304, + 203.88400000000001 + ], + "priority": 17, + "parents": [ + 19587 + ], + "children": [ + 19599 + ], + "area": 371614.748895, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 19599, + "strid": "f1c311e3-fd39-4bbd-a90f-c4c767081e41", + "image_id": 201273, + "image_name": "116860.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 460.81, + 1013.126, + 269.54400000000004, + 59.67800000000011 + ], + "priority": 18, + "parents": [ + 19595 + ], + "children": [], + "area": 466858.59206, + "iscrowd": 0, + "segmentation": [], + "text": "ur 3. Qvermatige botaanmank bi dysjakte van\nan Buchu, Weepscha met dog de sched\n\nvan gezonde personen (links) en eer chedel van een\n\npatiént met de ziekte van Van Buchem (rechts)." + }, + { + "id": 19588, + "strid": "7adc632e-c466-47c8-8c81-a3c275d784e0", + "image_id": 201273, + "image_name": "116860.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 562.835, + 213.438, + 81.30799999999999, + 18.10900000000001 + ], + "priority": 19, + "parents": [ + 19603 + ], + "children": [ + 19590 + ], + "area": 120130.37673, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusie" + }, + { + "id": 19590, + "strid": "c438a9cd-f593-41e9-b54c-c6cf448d84fc", + "image_id": 201273, + "image_name": "116860.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 562.214, + 259.28, + 229.87099999999998, + 250.957 + ], + "priority": 20, + "parents": [ + 19588 + ], + "children": [], + "area": 145770.84592, + "iscrowd": 0, + "segmentation": [], + "text": "2-ziekte van Van Buchem is\nzeldzame _botaandoening ie\nvoornamelik in Urk voo\ninderen presenteert de\nmeestal door perifere ui\nfacialis ten gevolge van\nde meatus acustict ternus.\nEen beter begrip van de onderliggende\npathofysiologische mechanismen van\nde ziekte leidt hopelijk in de toekomst\ntot fectieve behandeling. Er zijn\naanwijzingen dat patiénten met Van\njem baat hebben bij behandeling\n1et corticosteroiden. 7" + }, + { + "id": 107232, + "strid": "9c30298d-e197-489e-b139-79ab38d0dd82", + "image_id": 204652, + "image_name": "12693.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 1151.94, + 49.14, + 164.20000000000005, + 164.2 + ], + "priority": -1, + "parents": [], + "children": [ + 107215, + 107216, + 107224, + 107214, + 107223, + 107229, + 107231, + 107230, + 107222 + ], + "area": 56606.331600000005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 107214, + "strid": "ae807af4-5106-4386-800b-280d1bfde4a0", + "image_id": 204652, + "image_name": "12693.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 1539.263, + 87.604, + 2808.2959999999994, + 115.028 + ], + "priority": 1, + "parents": [ + 107232 + ], + "children": [], + "area": 134845.595852, + "iscrowd": 0, + "segmentation": [], + "text": "IN COLOUR DISCRIMINATION" + }, + { + "id": 107215, + "strid": "0dccb8b7-9f6b-4e5a-b825-46a2eed2368c", + "image_id": 204652, + "image_name": "12693.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 187.525, + 266.446, + 5135.264, + 339.563 + ], + "priority": 2, + "parents": [ + 107232 + ], + "children": [], + "area": 49965.28615000001, + "iscrowd": 0, + "segmentation": [], + "text": "Leticia Alvaro1*, Jodo M.M. Linhares2, Talia Alit, Monika A. Formankiewicz!, Sarah J. Waugh!\n1 Anglia Vision Research, Vision and Hearing Sciences, Faculty of Science and Technology, Anglia Ruskin University, Cambridge CB1 1PT, United Kingdom\nCentre of Physics, Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal\n\n* Leticia.Alvaro@anglia.ac.uk ee\n\nA. 1 deg" + }, + { + "id": 107216, + "strid": "a5d0e799-9479-41e8-bc57-d50b02630f9f", + "image_id": 204652, + "image_name": "12693.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 192.026, + 670.207, + 3122.198, + 102.06899999999996 + ], + "priority": 3, + "parents": [ + 107232 + ], + "children": [], + "area": 128697.16938200001, + "iscrowd": 0, + "segmentation": [], + "text": "PURPOSE: In this work we obtained colour discrimination thresholds for a number of hue angles, stimulus sizes and blur levels to study\nthe effects of blur in colour discrimination." + }, + { + "id": 107230, + "strid": "d1c9b059-e27e-436e-b6b2-31bcb0b1acb3", + "image_id": 204652, + "image_name": "12693.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 195.774, + 844.636, + 405.452, + 46.01999999999998 + ], + "priority": 4, + "parents": [ + 107232 + ], + "children": [ + 107217 + ], + "area": 165357.76826399998, + "iscrowd": 0, + "segmentation": [], + "text": "INTRODUCTION" + }, + { + "id": 107217, + "strid": "0896b9b7-48f1-4da7-9ec5-e0e7679f8623", + "image_id": 204652, + "image_name": "12693.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 192.607, + 895.357, + 3122.179, + 235.07999999999993 + ], + "priority": 5, + "parents": [ + 107230 + ], + "children": [], + "area": 172452.025699, + "iscrowd": 0, + "segmentation": [], + "text": "Previous research has looked into the effect of blur on clinical colour vision testing. Results from a seminal study by Gordon & Field (1978) showed an\nimprovement on Ishihara performance by defocusing the plates with a projector, but Taylor and Woodhouse (1979) were unable to replicate this result using\noptical blur. In a more recent study (Thyagarajan et al., 2007) FM1i00 and CCT test results were significantly affected with +6D blur, whereas Ishihara was\nnot. FM100, CCT and Ishihara results were robust up to +3D blur. Thus blur impairs colour discrimination but the actual extent of this impairment has not\nbeen systematically investigated across hue." + }, + { + "id": 107229, + "strid": "409033a9-5527-4ce7-84f3-afbdc5222d10", + "image_id": 204652, + "image_name": "12693.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 189.426, + 1190.537, + 220.96499999999997, + 45.914999999999964 + ], + "priority": 6, + "parents": [ + 107232 + ], + "children": [ + 107218 + ], + "area": 225518.661762, + "iscrowd": 0, + "segmentation": [], + "text": "METHOD" + }, + { + "id": 107218, + "strid": "72ade865-4839-4bc7-a675-9c9c586c47bd", + "image_id": 204652, + "image_name": "12693.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 191.326, + 1245.493, + 3127.593, + 515.623 + ], + "priority": 7, + "parents": [ + 107229 + ], + "children": [], + "area": 238295.19371799997, + "iscrowd": 0, + "segmentation": [], + "text": "A colour discrimination task (Linhares et al., 2016) was performed on a calibrated CRT monitor (GDM-F520, Sony Corp.) controlled by a ViSaGe-MKII\n(Cambridge Research Systems). Small achromatic circles of random diameter were presented over an achromatic background. A square chromatic target\n\nconstructed out of the chromatic circles was presented on the achromatic static luminance noise background. Observers indicated the location of the square\n(right or left side of the screen).\n\nThe circles’ luminances ranged randomly from 6 to 16 cd/m2. Target hue was varied along 22 hues originating from the background colour (or neutral point) -\nincluding six segments of the protan (h,, = 4°; h,, = 184°), deutan (h,, = 168°; h,, = 148°) and tritan (h,, = 98°; h,, = 278°) confusion lines (Smith and\nPokorny, 1975).\n\nDiscrimination thresholds were measured on repeated occasions using a staircase procedure. Five observers with corrected-to-normal visual acuity performed\nthe task monocularly without blur and with four levels of refractive blur: +1 to +4D for a 1 deg sized target, and +2 to +8D for a 5 deg sized target." + }, + { + "id": 107231, + "strid": "cf20453a-efc2-487a-bf6d-c1ef00d8669b", + "image_id": 204652, + "image_name": "12693.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 194.303, + 1798.398, + 223.26300000000003, + 41.00800000000004 + ], + "priority": 8, + "parents": [ + 107232 + ], + "children": [ + 107219, + 107228, + 107213 + ], + "area": 349434.126594, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 107219, + "strid": "74ce2c7d-eccd-4a5c-89e9-d23f42b1f8e3", + "image_id": 204652, + "image_name": "12693.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 188.335, + 1848.223, + 3130.584, + 323.54399999999987 + ], + "priority": 9, + "parents": [ + 107231 + ], + "children": [], + "area": 348085.078705, + "iscrowd": 0, + "segmentation": [], + "text": "Colour differences (AE™*,,,) between target threshold and background were calculated. The effect of blur was estimated from the difference in AE*,,, between\nthe blur and no blur conditions. A repeated measures ANOVA (size, blur and hue) revealed significant size [F(1,4) = 26.82; P <0.01], blur [F(3,12) = 51.51;\nP <0.001], hue [F(21,84) = 2.28; P <0.01] effects, size*blur [F(3,12) = 34.12; P <0.001], size*hue [F(21,84) = 3.51; P <0.001] and blur*hue [F(63,252)\n= 1.70; P <0.01] interactions. Blur affected colour discrimination more for the smaller target, where thresholds were lower. Tukey post-hoc comparisons on\nthe blur*hue interaction are reported in Table 1. Stimuli were measured with a PR-650 with and without the highest blur level (+8D) finding small average\ndifferences for all the hues: AL = 1.7; Au’ = 0.001; Av’ = 0.003 so the results cannot be explained by differential effects of blurring lenses on spectral\ntransmittance." + }, + { + "id": 107228, + "strid": "60252ce2-36d5-4a7d-90ae-9568cea4312a", + "image_id": 204652, + "image_name": "12693.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 193.607, + 2212.569, + 2829.523, + 498.77199999999993 + ], + "priority": 10, + "parents": [ + 107231 + ], + "children": [ + 107227 + ], + "area": 428368.84638299997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 107227, + "strid": "da0d1792-dd6a-40c5-80d1-c3aa5c9062e1", + "image_id": 204652, + "image_name": "12693.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 189.337, + 2730.24, + 1588.85, + 53.483000000000175 + ], + "priority": 11, + "parents": [ + 107228 + ], + "children": [], + "area": 516935.4508799999, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1. Significant post-hoc comparisons on the blur*hue interaction (P <0.05)." + }, + { + "id": 107213, + "strid": "b17a3d6a-2d74-4a73-90dd-c0e3b481ce79", + "image_id": 204652, + "image_name": "12693.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3478.659, + 477.183, + 1999.225, + 2514.89 + ], + "priority": 12, + "parents": [ + 107231 + ], + "children": [ + 107226 + ], + "area": 1659956.937597, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 107226, + "strid": "852464c9-826c-44ec-a30a-dcf7753fed2f", + "image_id": 204652, + "image_name": "12693.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 3503.903, + 3019.74, + 1938.5170000000003, + 233.78099999999995 + ], + "priority": 13, + "parents": [ + 107213 + ], + "children": [], + "area": 10580876.045219999, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. Average discrimination thresholds for different blur levels. Line thickness indicates blur\nlevel: no blur (thinnest), +1D, +2D, +3D, +4D (thickest) for 1 deg stimulus size (1A); no blur\n(thinnest), +2D, +4D, +6D, +8D (thickest) for 5 deg stimulus size (1B). Marker colours are\napproximations of hues presented at maximum saturation. Vertical lines represent the two\nextremes of the protan (red), deutan (green) or tritan (blue) lines." + }, + { + "id": 107222, + "strid": "67ddfd7e-6935-448a-8758-ad46b51eafac", + "image_id": 204652, + "image_name": "12693.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 197.308, + 2867.736, + 321.453, + 42.23999999999978 + ], + "priority": 14, + "parents": [ + 107232 + ], + "children": [ + 107220 + ], + "area": 565827.254688, + "iscrowd": 0, + "segmentation": [], + "text": "DISCUSSION" + }, + { + "id": 107220, + "strid": "408ccbb2-23b4-46c0-b0ef-6dfe5377440c", + "image_id": 204652, + "image_name": "12693.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 193.222, + 2919.651, + 3115.75, + 94.34000000000015 + ], + "priority": 15, + "parents": [ + 107222 + ], + "children": [], + "area": 564140.805522, + "iscrowd": 0, + "segmentation": [], + "text": "Stronger effects of blur occur for the discrimination of hues near the tritan confusion lines. These results may hold implications for colour vision research\nespecially in developing, aging and diseased populations for whom uncorrected refractive error could mimic losses along tritan confusion lines." + }, + { + "id": 107224, + "strid": "9d4ecd0a-ec2e-45d0-8874-02c90cb68132", + "image_id": 204652, + "image_name": "12693.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3491.934, + 3291.53, + 465.9830000000002, + 35.858999999999924 + ], + "priority": 16, + "parents": [ + 107232 + ], + "children": [ + 107225 + ], + "area": 11493805.51902, + "iscrowd": 0, + "segmentation": [], + "text": "ACKNOWLEDGEM" + }, + { + "id": 107225, + "strid": "5dbdcf5d-a07c-463b-a877-dd1220e40d54", + "image_id": 204652, + "image_name": "12693.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3489.721, + 3333.26, + 1968.2689999999998, + 141.9760000000001 + ], + "priority": 17, + "parents": [ + 107224 + ], + "children": [], + "area": 11632147.42046, + "iscrowd": 0, + "segmentation": [], + "text": "This work was supported by an Evelyn Trust Grant (to SJW), an Anglia Ruskin University/FST\nUndergraduate Summer Research Placement (to TA) and HEFCE QR (Quality Related) Funds (to\nAnglia Vision Research) to support a Postdoctoral Research Fellow (LA)." + }, + { + "id": 107223, + "strid": "c9483fee-7874-47a7-9af3-8e0b5b789963", + "image_id": 204652, + "image_name": "12693.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 192.905, + 3056.356, + 284.40100000000007, + 35.67099999999982 + ], + "priority": 18, + "parents": [ + 107232 + ], + "children": [ + 107221 + ], + "area": 589586.35418, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 107221, + "strid": "93b9db90-b32f-468a-8b84-20fe2454d35a", + "image_id": 204652, + "image_name": "12693.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 184.221, + 3102.163, + 3132.021, + 373.9180000000001 + ], + "priority": 19, + "parents": [ + 107223 + ], + "children": [], + "area": 571483.570023, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 54943, + "strid": "f4f87af8-40e2-4e4c-a265-31b7b6e303b3", + "image_id": 202661, + "image_name": "119056.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 439.56, + 27.02, + 299.51000000000005, + 176.98 + ], + "priority": -1, + "parents": [], + "children": [ + 54925, + 54929, + 54924, + 54926, + 54927, + 54928, + 54930, + 54923 + ], + "area": 11876.9112, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 54923, + "strid": "fbe92230-f7bc-4249-b724-aaa00e6d2ae7", + "image_id": 202661, + "image_name": "119056.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 766.861, + 107.454, + 3148.509, + 314.851 + ], + "priority": 1, + "parents": [ + 54943 + ], + "children": [], + "area": 82402.281894, + "iscrowd": 0, + "segmentation": [], + "text": "Android based data collection in a nutritional:survey:\na feasibility study i inChad ~”" + }, + { + "id": 54924, + "strid": "1fbff5bb-ea59-4cd6-ac08-0a1980960dd1", + "image_id": 202661, + "image_name": "119056.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 771.522, + 613.85, + 3135.778, + 209.73300000000006 + ], + "priority": 2, + "parents": [ + 54943 + ], + "children": [], + "area": 473598.7797000001, + "iscrowd": 0, + "segmentation": [], + "text": "France Broillet', Ludovic Rossel2, Médecins Sans Frontiéres OCG\n’ Nutrition referent - 7Medical data manager" + }, + { + "id": 54925, + "strid": "68a51ad8-b775-4c69-a7c9-b4a91257680c", + "image_id": 202661, + "image_name": "119056.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 155.474, + 958.13, + 345.243, + 57.99400000000003 + ], + "priority": 3, + "parents": [ + 54943 + ], + "children": [ + 54939 + ], + "area": 148964.30362, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 54939, + "strid": "46348f23-bd41-4074-9914-2040157abb0b", + "image_id": 202661, + "image_name": "119056.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 155.079, + 1128.488, + 957.701, + 685.588 + ], + "priority": 4, + "parents": [ + 54925 + ], + "children": [], + "area": 175004.79055200002, + "iscrowd": 0, + "segmentation": [], + "text": "Household surveys are regularly carried out in difficult\nenvironments by MSF. Objectives are becoming ambitious,\nquestionnaires are longer and more complex.\n\nNew technologies such as tablets and electronic questionnaires\noffer a potential to save time and money compared to paper\nbased data collection while also improving data quality and\nallowing immediate data control.\n\nFor these reasons, MSF decided to evaluate the feasibility of\nusing touch-screen questionnaires in a regular nutritional survey\nin Chad." + }, + { + "id": 54929, + "strid": "dc593057-e20a-47c8-b806-18a3a3970c47", + "image_id": 202661, + "image_name": "119056.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 152.568, + 2166.259, + 114.78, + 52.67900000000009 + ], + "priority": 5, + "parents": [ + 54943 + ], + "children": [ + 54940, + 54941 + ], + "area": 330501.80311200005, + "iscrowd": 0, + "segmentation": [], + "text": "Aim" + }, + { + "id": 54940, + "strid": "a63a5fe4-2c17-4df4-819d-ec8051b075bd", + "image_id": 202661, + "image_name": "119056.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 153.947, + 2258.592, + 974.7309999999999, + 191.8040000000001 + ], + "priority": 6, + "parents": [ + 54929 + ], + "children": [], + "area": 347703.46262400004, + "iscrowd": 0, + "segmentation": [], + "text": "Evaluate the feasibility of electronic data collection for household\nsurveys in difficult environments, in particular in relation to\nhandling and acceptance by staff, technical constraints, data\ncollection, management and quality." + }, + { + "id": 54941, + "strid": "0042f4aa-5dec-42b3-b215-63bfe7c2044a", + "image_id": 202661, + "image_name": "119056.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 157.385, + 2600.764, + 969.9930000000002, + 534.6239999999998 + ], + "priority": 7, + "parents": [ + 54929 + ], + "children": [], + "area": 409321.24214, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 54926, + "strid": "66ce3855-6cd4-4c65-915c-01773c55fa35", + "image_id": 202661, + "image_name": "119056.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1285.649, + 956.175, + 218.40599999999995, + 55.38199999999995 + ], + "priority": 8, + "parents": [ + 54943 + ], + "children": [ + 54938, + 54942 + ], + "area": 1229305.4325749998, + "iscrowd": 0, + "segmentation": [], + "text": "Method" + }, + { + "id": 54938, + "strid": "4e1b2c2b-80ed-44a4-bd1e-7d8a148768bc", + "image_id": 202661, + "image_name": "119056.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1284.307, + 1123.488, + 974.1519999999998, + 843.367 + ], + "priority": 9, + "parents": [ + 54926 + ], + "children": [], + "area": 1442903.502816, + "iscrowd": 0, + "segmentation": [], + "text": "There were 5 teams.of 2 surveyors with a car at disposal.\n\nIn each team, one surveyor worked with paper based\nquestionnaires, the other with Nexus 07 Android 4.1 tablet. To\nrecharge the tablets, an external battery was provided, to be\ncharged during the day through the car power adapter.\n\nAll. staff were already accustomed to the survey itself. Surveyors\nusing tablets benefited from a three hours training on the use of\nthe device and close coaching during the first days of the survey.\n\nData was downloaded to a USB keys by surveyors on a daily\nbasis and then transferred by the survey manager to a data\nanalysis software (QlickView ) for immediate data quality check.\n\nDuring the ten days of the survey, the survey manager observed\nthe data collection process. At the end, an analysis was\nperformed on EpiData to compare the quality of data collected\nvia paper questionnaires and that of data collected with tablets." + }, + { + "id": 54942, + "strid": "a78b1d57-a735-4c4b-aa81-560cd1b058d2", + "image_id": 202661, + "image_name": "119056.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1292.267, + 2181.337, + 967.6789999999999, + 953.9459999999999 + ], + "priority": 10, + "parents": [ + 54926 + ], + "children": [], + "area": 2818869.820979, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 54927, + "strid": "a6f951f4-e2bf-49c3-a6a8-f316094610d8", + "image_id": 202661, + "image_name": "119056.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2413.775, + 958.591, + 214.86299999999983, + 57.07299999999998 + ], + "priority": 11, + "parents": [ + 54943 + ], + "children": [ + 54937, + 54933, + 54932, + 54935, + 54936 + ], + "area": 2313822.991025, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 54937, + "strid": "b4772fbf-4e23-4275-b782-755b6d46dbfd", + "image_id": 202661, + "image_name": "119056.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2414.288, + 1128.845, + 962.2939999999999, + 539.969 + ], + "priority": 12, + "parents": [ + 54927 + ], + "children": [], + "area": 2725356.93736, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 54936, + "strid": "585f4a01-5806-453d-a84a-1176287f37f8", + "image_id": 202661, + "image_name": "119056.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2413.803, + 1855.026, + 972.692, + 590.3929999999998 + ], + "priority": 13, + "parents": [ + 54927 + ], + "children": [], + "area": 4477667.323878, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 54935, + "strid": "3cd5082e-8d4a-47c0-9878-fbfd499175ea", + "image_id": 202661, + "image_name": "119056.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2414.722, + 2628.937, + 964.4360000000001, + 410.14699999999993 + ], 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"image_name": "119056.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 3644.469, + 1929.099, + 657.1700000000001, + 29.09400000000005 + ], + "priority": 17, + "parents": [ + 54933 + ], + "children": [], + "area": 7030541.503431, + "iscrowd": 0, + "segmentation": [], + "text": "Dynamic rules prevent erroneous values and bypass of questions" + }, + { + "id": 54928, + "strid": "2cf45aa3-bd3a-4f79-9687-7550d3ff9610", + "image_id": 202661, + "image_name": "119056.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3543.996, + 2113.41, + 319.4659999999999, + 54.414000000000215 + ], + "priority": 18, + "parents": [ + 54943 + ], + "children": [ + 54931 + ], + "area": 7489916.58636, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion" + }, + { + "id": 54931, + "strid": "5ca81df9-62e4-4113-b624-e992c1b006ab", + "image_id": 202661, + "image_name": "119056.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3545.247, + 2208.299, + 979.4140000000002, + 590.1480000000001 + ], + "priority": 19, + "parents": [ + 54928 + ], + "children": [], + "area": 7828965.404852999, + "iscrowd": 0, + "segmentation": [], + "text": "Although challenges remain regarding power autonomy and\nsupply, the study shows that it is possible and beneficial to use\nelectronic devices for data collection in a difficult environment.\nIn that respect, use of solar batteries will soon be tested.\n\nThe study also confirms that electronic data collection minimizes\nrisk of of error (through dynamic rules), while allowing immediate\ndata quality check and faster use of data.\n\nEven though tablets require an initial investment, in the long term,\nthey can substantially reduce expenses and time required to\nconduct traditionnal survey (duplication of forms, filing, stationary\nexpenses, secondary data entry, etc.)." + }, + { + "id": 54930, + "strid": "30dde1d3-1345-43f3-b60c-ba471ee4f756", + "image_id": 202661, + "image_name": "119056.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3549.771, + 2952.512, + 886.8830000000003, + 90.95600000000013 + ], + "priority": 20, + "parents": [ + 54943 + ], + "children": [], + "area": 10480741.474752001, + "iscrowd": 0, + "segmentation": [], + "text": "Ethical review was not required for this study. There was no\nconflict of interest and no external funding." + }, + { + "id": 61715, + "strid": "4be7dd30-5418-42aa-8ff9-f417cfdacaef", + "image_id": 202933, + "image_name": "119468.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 2413.64, + 77.03, + 187.73000000000002, + 408.99 + ], + "priority": -1, + "parents": [], + "children": [ + 61695, + 61697, + 61694, + 61698, + 61696 + ], + "area": 185922.6892, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61694, + "strid": "8c4274c6-b0ad-41ed-8fa0-2b4a2be18d78", + "image_id": 202933, + "image_name": "119468.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 58.993, + 88.108, + 2305.858, + 259.586 + ], + "priority": 1, + "parents": [ + 61715 + ], + "children": [], + "area": 5197.755244000001, + "iscrowd": 0, + "segmentation": [], + "text": "Ultrafast Approximation for Phylogenetic\nBootstrap" + }, + { + "id": 61695, + "strid": "d81a4358-13de-4abc-b2eb-04e2d6baefb1", + "image_id": 202933, + "image_name": "119468.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 53.679, + 389.576, + 2286.157, + 271.155 + ], + "priority": 2, + "parents": [ + 61715 + ], + "children": [], + "area": 20912.050104, + "iscrowd": 0, + "segmentation": [], + "text": "Bui Quang Minh, Minh Anh Thi Nguyen, and Arndt von Haeseler\n\nCenter for Integrative Bioinformatics Vienna (CIBIV), Austria\nSoftware freely available at http: //www.cibiv.at/software/igqtree" + }, + { + "id": 61696, + "strid": "5d3e89e4-18ec-4c41-ade7-0745ced73d33", + "image_id": 202933, + "image_name": "119468.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 77.031, + 761.108, + 302.883, + 58.35400000000004 + ], + "priority": 3, + "parents": [ + 61715 + ], + "children": [ + 61699, + 61701, + 61700 + ], + "area": 58628.910348, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 61699, + "strid": "f4852e9e-7c19-4325-9b80-ae749878f09b", + "image_id": 202933, + "image_name": "119468.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 78.357, + 857.767, + 997.854, + 698.4970000000001 + ], + "priority": 4, + "parents": [ + 61696 + ], + "children": [], + "area": 67212.048819, + "iscrowd": 0, + "segmentation": [], + "text": "The nonparametric bootstrap of Felsen-\nstein (1985) is the de facto standard for\nphylogenetic analysis to assess branch\nsupports of phylogenetic trees. Yet\nbootstrap with maximum likelihood\n(ML) is hampered by the enormous\ncomputation time required.\n\nHere, we present an ultrafast boot-\nstrap approximation approach (UF-\nBoot) with the following advantages:" + }, + { + "id": 61701, + "strid": "e63fe01c-2c76-4d12-985f-60ac29c1c8f0", + "image_id": 202933, + "image_name": "119468.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 126.557, + 1586.138, + 949.5709999999999, + 555.5839999999998 + ], + "priority": 5, + "parents": [ + 61696 + ], + "children": [], + "area": 200736.866866, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61700, + "strid": "8cdcfa82-62da-4d82-a7c3-e6ae3cd650e1", + "image_id": 202933, + "image_name": "119468.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 78.552, + 2167.469, + 993.341, + 162.59400000000005 + ], + "priority": 6, + "parents": [ + 61696 + ], + "children": [], + "area": 170259.024888, + "iscrowd": 0, + "segmentation": [], + "text": "Minh B.Q., Nguyen M.A.T., and von Haeseler A.\n(2013) Mol. Biol. Evol., 30:1188-1195. (Open Ac-\ncess Article)" + }, + { + "id": 61698, + "strid": "491eea07-1565-4204-b063-3634e288c7f4", + "image_id": 202933, + "image_name": "119468.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 78.76, + 2440.669, + 401.262, + 54.19300000000021 + ], + "priority": 7, + "parents": [ + 61715 + ], + "children": [ + 61705, + 61703, + 61706, + 61702, + 61704 + ], + "area": 192227.09044, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 61702, + "strid": "64d809c2-3f12-481c-8a73-4fd84456f750", + "image_id": 202933, + "image_name": "119468.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 79.033, + 2547.853, + 996.2979999999999, + 310.0340000000001 + ], + "priority": 8, + "parents": [ + 61698 + ], + "children": [], + "area": 201364.466149, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61703, + "strid": "31bd963a-b4f3-4264-9686-a130a81737cb", + "image_id": 202933, + "image_name": "119468.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 80.476, + 2889.708, + 411.226, + 57.47600000000011 + ], + "priority": 9, + "parents": [ + 61698 + ], + "children": [], + "area": 232552.141008, + "iscrowd": 0, + "segmentation": [], + "text": "2. Exploration step" + }, + { + "id": 61705, + "strid": "8f6ea8c9-6b9d-436c-9ed0-0e4df0c3d10c", + "image_id": 202933, + "image_name": "119468.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 129.903, + 2972.358, + 912.653, + 538.4099999999999 + ], + "priority": 10, + "parents": [ + 61698 + ], + "children": [], + "area": 386118.221274, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61704, + "strid": "6aadaefc-0746-4a59-baa5-dd1ead3b8ff4", + "image_id": 202933, + "image_name": "119468.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 147.981, + 3575.522, + 926.711, + 587.473 + ], + "priority": 11, + "parents": [ + 61698 + ], + "children": [], + "area": 529109.3210819999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61706, + "strid": "26e0ab12-2dca-4e8e-862c-e2814d307edc", + "image_id": 202933, + "image_name": "119468.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 78.721, + 4208.549, + 995.854, + 159.90899999999965 + ], + "priority": 12, + "parents": [ + 61698 + ], + "children": [], + "area": 331301.185829, + "iscrowd": 0, + "segmentation": [], + "text": "3. Summarization step. Construct a consensus\ntree from {T},...,7%} and place support val-\nues on the ML tree." + }, + { + "id": 61697, + "strid": "02d8deef-b827-4e2d-b266-5fe61d15f268", + "image_id": 202933, + "image_name": "119468.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1157.424, + 759.806, + 192.88799999999992, + 58.93799999999999 + ], + "priority": 13, + "parents": [ + 61715 + ], + "children": [ + 61708, + 61710, + 61707, + 61714, + 61713, + 61711, + 61712, + 61709 + ], + "area": 879417.699744, + "iscrowd": 0, + "segmentation": [], + "text": "asters)" + }, + { + "id": 61707, + "strid": "f2fbb9ff-3b96-42ab-8f5d-f047ff00cc02", + "image_id": 202933, + "image_name": "119468.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1405.43, + 870.048, + 1579.003, + 56.085000000000036 + ], + "priority": 14, + "parents": [ + 61697 + ], + "children": [], + "area": 1222791.56064, + "iscrowd": 0, + "segmentation": [], + "text": "1. UFBoot is unbiased while other methods are conservative:" + }, + { + "id": 61712, + "strid": "eb3d74d2-17de-4de3-8a5f-82a08435f269", + "image_id": 202933, + "image_name": "119468.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1265.246, + 943.446, + 1827.6930000000002, + 911.93 + ], + "priority": 15, + "parents": [ + 61697 + ], + "children": [], + "area": 1193691.277716, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61708, + "strid": "735cfea2-a37c-42b3-808d-7eb21187fc36", + "image_id": 202933, + "image_name": "119468.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1478.965, + 1897.993, + 1429.097, + 66.35200000000009 + ], + "priority": 16, + "parents": [ + 61697 + ], + "children": [], + "area": 2807065.217245, + "iscrowd": 0, + "segmentation": [], + "text": "2. UFBoot is robust against moderate model violations:" + }, + { + "id": 61713, + "strid": "2d2b56c3-b295-4141-bd2c-0e3796c87cea", + "image_id": 202933, + "image_name": "119468.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1268.642, + 1983.372, + 1823.6249999999998, + 916.6690000000001 + ], + "priority": 17, + "parents": [ + 61697 + ], + "children": [], + "area": 2516189.0208240002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61711, + "strid": "c074f3b2-8d4b-4f05-bd3d-08a842aa44c9", + "image_id": 202933, + "image_name": "119468.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1158.561, + 2965.072, + 2074.9090000000006, + 129.4699999999998 + ], + "priority": 18, + "parents": [ + 61697 + ], + "children": [], + "area": 3435216.7813919997, + "iscrowd": 0, + "segmentation": [], + "text": "SBS - standard bootstrap, RBS - RAxML rapid bootstrap, SH-aLRT - Shimodaira-Hasegawa-like\napproximate likelihood ratio test (PhyML). These accuracy plots follow Hillis and Bull (1993)." + }, + { + "id": 61709, + "strid": "a3cfd93d-7d1d-4bf3-9115-5efac70f2ba2", + "image_id": 202933, + "image_name": "119468.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1187.985, + 3179.448, + 969.2720000000002, + 119.01699999999983 + ], + "priority": 19, + "parents": [ + 61697 + ], + "children": [], + "area": 3777136.5322799995, + "iscrowd": 0, + "segmentation": [], + "text": "3. UFBoot is substantially faster than\nRBS:" + }, + { + "id": 61714, + "strid": "a426b36e-fbde-4476-8faa-989ca975e3e5", + "image_id": 202933, + "image_name": "119468.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1178.023, + 3307.887, + 996.0959999999998, + 1027.815 + ], + "priority": 20, + "parents": [ + 61697 + ], + "children": [], + "area": 3896766.9674009997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 61710, + "strid": "0d927940-3f47-413e-a13e-8e24fa0196c6", + "image_id": 202933, + "image_name": "119468.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2275.396, + 3177.753, + 959.1950000000002, + 1173.5859999999998 + ], + "priority": 21, + "parents": [ + 61697 + ], + "children": [], + "area": 7230646.465188001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 145382, + "strid": "c431df1e-8010-470f-af07-707b59e8202d", + "image_id": 206145, + "image_name": "18337.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 1930.37, + 347.9, + 287.27, + 188.21000000000004 + ], + "priority": -1, + "parents": [], + "children": [ + 145364, + 145366, + 145362, + 145360, + 145365, + 145361, + 145363 + ], + "area": 671575.7229999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 145360, + "strid": "6daa854c-c61e-4bd4-aaa4-8ec08d09e872", + "image_id": 206145, + "image_name": "18337.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 76.098, + 323.328, + 1667.449, + 252.65100000000007 + ], + "priority": 1, + "parents": [ + 145382 + ], + "children": [], + "area": 24604.614144, + "iscrowd": 0, + "segmentation": [], + "text": "Linear and non-linear association analysis\n\nof genomic ranges annotations" + }, + { + "id": 145361, + "strid": "f4aae88b-3881-49ae-9b0d-4466af22b391", + "image_id": 206145, + "image_name": "18337.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 74.706, + 76.399, + 1517.762, + 168.441 + ], + "priority": 2, + "parents": [ + 145382 + ], + "children": [], + "area": 5707.463694, + "iscrowd": 0, + "segmentation": [], + "text": "Authors: Annika Birger*, Martin Dugas\n\nInstitute of Medical Informatics, University of Munster, Germany" + }, + { + "id": 145362, + "strid": "e8d85ec0-a52f-4126-ac7b-bf0160d0e145", + "image_id": 206145, + "image_name": "18337.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 136.917, + 778.503, + 408.44899999999996, + 69.88499999999999 + ], + "priority": 3, + "parents": [ + 145382 + ], + "children": [ + 145367 + ], + "area": 106590.295251, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 145367, + "strid": "84007502-9213-4940-8241-c8e67c45009d", + "image_id": 206145, + "image_name": "18337.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 131.861, + 888.658, + 1443.7960000000003, + 401.948 + ], + "priority": 4, + "parents": [ + 145362 + ], + "children": [], + "area": 117179.33253799999, + "iscrowd": 0, + "segmentation": [], + "text": "With NGS there arise plenty genomic data. Lists of annotated genomic\nranges from a biological setting have to be analyzed to answer specific\nscientific questions. To understand the data it is necessary to analyze the\nannotations of the genomic intervals as well as to analyze the assoziation\nbetween multiple sets of genomic ranges and their annotations. Linear and\n\nnon-linar correlations have to be taken into account." + }, + { + "id": 145363, + "strid": "6c82d5b1-b6ee-4920-85d9-d75f2d41f1f5", + "image_id": 206145, + "image_name": "18337.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 138.72, + 1434.554, + 290.6809999999999, + 68.78199999999993 + ], + "priority": 5, + "parents": [ + 145382 + ], + "children": [ + 145368, + 145369, + 145376 + ], + "area": 199001.33088000002, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 145368, + "strid": "e4dfa497-b994-4c95-a47a-0c152be286dc", + "image_id": 206145, + "image_name": "18337.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 132.933, + 1544.636, + 1444.868, + 409.451 + ], + "priority": 6, + "parents": [ + 145363 + ], + "children": [], + "area": 205333.097388, + "iscrowd": 0, + "segmentation": [], + "text": "Starting point of our analysis is a set of annotated genomic intervals (chro-\nmosom, start, end and columns of further information) from the same\ngenome. Examples include analyzed CHiP-seq data, methylation data or\nRNA-seq data. In a first step all intervals are linked to the nearest known\ngene [Figure 1] and the annotations are aggregated in different ways de-\n\npending on their scale and kind." + }, + { + "id": 145376, + "strid": "f7fde08d-7125-48a0-a810-0e6a7f4b6ff5", + "image_id": 206145, + "image_name": "18337.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 296.27, + 1988.671, + 1117.374, + 375.3100000000002 + ], + "priority": 7, + "parents": [ + 145363 + ], + "children": [ + 145379 + ], + "area": 589183.5571699999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 145379, + "strid": "b2b9679b-cc86-4d9c-a5c0-fc16d6516a1c", + "image_id": 206145, + "image_name": "18337.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 599.497, + 2408.268, + 509.6619999999999, + 24.93199999999979 + ], + "priority": 8, + "parents": [ + 145376 + ], + "children": [], + "area": 1443749.441196, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1: Mapping genomic intervals to nearest gene." + }, + { + "id": 145369, + "strid": "3f8396d0-d413-4011-a329-9aaf4fde709e", + "image_id": 206145, + "image_name": "18337.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 133.684, + 2496.325, + 1443.049, + 1129.6599999999999 + ], + "priority": 9, + "parents": [ + 145363 + ], + "children": [], + "area": 333718.71129999997, + "iscrowd": 0, + "segmentation": [], + "text": "In a second step the resulting gene annotations are categorized and sum-\nmarized according to their scale (binary, nominal, ordinal, interval and\nrational). To visualize categorical data ordered or unordered barplots are\navailable. For metric data for example histograms or boxplots are suitable.\nFurthermore, annotations are grouped and compared [Figure 2].\n\nThen an adequate statistic model is chosen to find possible linear and\nnon-linear assoziations between the annotations. We use for this among\nothers correlation coefficients like Pearson correlation, t-test, Wilcoxon-\nrank sum test, Kruskal-Wallis test and fisher exact test as well as non-linear\ncharacteristics like mutual information.\n\nThe results are automatically reported in a HTML document to allow the\nuser an easy overview and help to differentiate between significant depen-\ndencies and random effects. All pair-wise comparisons are summarized in\na heatmap [Figure 3].\n\nFor implementation we choose R. In R/Bioconductor annotated genomic\n\nranges can be easily handled as GRanges objects [1]." + }, + { + "id": 145364, + "strid": "293c7183-59f2-4726-a60b-6d97905c21c3", + "image_id": 206145, + "image_name": "18337.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 138.358, + 3759.91, + 236.976, + 69.15299999999979 + ], + "priority": 10, + "parents": [ + 145382 + ], + "children": [ + 145370, + 145378, + 145377, + 145373, + 145371, + 145372 + ], + "area": 520213.62778, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 145370, + "strid": "3cc93cbf-a268-49d8-ac93-4e94c79142f2", + "image_id": 206145, + "image_name": "18337.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 134.666, + 3871.416, + 1441.588, + 337.48199999999997 + ], + "priority": 11, + "parents": [ + 145364 + ], + "children": [], + "area": 521348.10705600004, + "iscrowd": 0, + "segmentation": [], + "text": "To validate our tool we reanalyzed a published dataset with CHiP-seq,\nRRBS and RNA-seq data from mouse embryonic stem cells [2]. The paper\nstates that DNA methylation reversibly alters occupancy of histone mod-\nification in regulatory regions like promoters and enhancers. We chose a\nsubset of the dataset with CHiP-seq, RRBS data and RNA-data for each" + }, + { + "id": 145371, + "strid": "84df7f6d-1a41-4c61-a3b2-c62e401483fc", + "image_id": 206145, + "image_name": "18337.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1743.726, + 779.935, + 1444.105, + 339.2629999999999 + ], + "priority": 12, + "parents": [ + 145364 + ], + "children": [], + "area": 1359992.93781, + "iscrowd": 0, + "segmentation": [], + "text": "wildtype J1, demethylated cells DKO and remethylated cells DKO3al1,\nDKO3a2, DKO3b1. First all data was linked to known genes with max.\ndistance 100.000 bp and the annotated values were aggregated per gene.\nThen, all annotations of the genes are summarized individually as well as\nin groups [Figure 2]." + }, + { + "id": 145377, + "strid": "d42b961b-3333-4e35-8166-f40d9ad93885", + "image_id": 206145, + "image_name": "18337.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1999.094, + 1215.981, + 904.6950000000002, + 536.9109999999998 + ], + "priority": 13, + "parents": [ + 145364 + ], + "children": [ + 145381 + ], + "area": 2430860.321214, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 145381, + "strid": "69b14819-fb82-4aba-8815-a349b898142e", + "image_id": 206145, + "image_name": "18337.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2173.231, + 1793.089, + 587.406, + 26.361000000000104 + ], + "priority": 14, + "parents": [ + 145377 + ], + "children": [], + "area": 3896796.6005590004, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2: Subset of RRBS data from |2] aggregated per gene." + }, + { + "id": 145372, + "strid": "14d9b5ee-a1ab-4aa5-b915-f8177275b5ad", + "image_id": 206145, + "image_name": "18337.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1746.26, + 1882.797, + 1441.0220000000002, + 124.327 + ], + "priority": 15, + "parents": [ + 145364 + ], + "children": [], + "area": 3287853.08922, + "iscrowd": 0, + "segmentation": [], + "text": "As summary a heatmap shows the pairwise correlations between the anno-\n\ntations [Figure 3]." + }, + { + "id": 145378, + "strid": "6561ad29-bd7b-4e52-844e-7408e462cecc", + "image_id": 206145, + "image_name": "18337.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2058.584, + 2068.212, + 834.4870000000001, + 654.614 + ], + "priority": 16, + "parents": [ + 145364 + ], + "children": [ + 145380 + ], + "area": 4257588.131808, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 145380, + "strid": "b6b8accc-38c9-4517-a41b-14d2bc6bdeee", + "image_id": 206145, + "image_name": "18337.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2250.877, + 2797.923, + 431.96900000000005, + 27.179999999999836 + ], + "priority": 17, + "parents": [ + 145378 + ], + "children": [], + "area": 6297780.528471, + "iscrowd": 0, + "segmentation": [], + "text": "ociation over\n\n \n\niew of dataset [2]" + }, + { + "id": 145373, + "strid": "78ccc80a-f4fc-4774-ad23-79950fb36d86", + "image_id": 206145, + "image_name": "18337.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1746.956, + 2886.42, + 1439.6629999999998, + 194.29199999999992 + ], + "priority": 18, + "parents": [ + 145364 + ], + "children": [], + "area": 5042448.73752, + "iscrowd": 0, + "segmentation": [], + "text": "Though p-values have been ajusted to multiple testing using Bonferroni\ncorrection the dataset seem to be highly correlated. Furthermore, normal-\n\nisation to gene could length prevent ambigous impressions." + }, + { + "id": 145365, + "strid": "96e1b879-9759-4a82-8daf-14b437dd9747", + "image_id": 206145, + "image_name": "18337.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1748.955, + 3180.896, + 710.2159999999999, + 89.5329999999999 + ], + "priority": 19, + "parents": [ + 145382 + ], + "children": [ + 145374 + ], + "area": 5563243.96368, + "iscrowd": 0, + "segmentation": [], + "text": "Outlook / Discussion" + }, + { + "id": 145374, + "strid": "767d937a-7b18-482c-a91e-d1d4ae6546b0", + "image_id": 206145, + "image_name": "18337.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1745.713, + 3293.769, + 1445.4980000000003, + 409.5920000000001 + ], + "priority": 20, + "parents": [ + 145365 + ], + "children": [], + "area": 5749975.362296999, + "iscrowd": 0, + "segmentation": [], + "text": "As our approach realizes multiple testing, identified dependencies need to\nbe further validated and can only be seen as explorative analysis. Our\nwork includes the comparison of two sets of genomic intervals like the\ntools StereoGene [3] and GenometriCorr [4] as well as the comparison of\nan arbitrary number of sets of genomic intervals due to the aggregation on\n\ngenes. Our future work we will improve the usability of our tool." + }, + { + "id": 145366, + "strid": "8298fccc-2975-40ec-a97a-20151c1b84bd", + "image_id": 206145, + "image_name": "18337.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1749.345, + 3832.055, + 355.47399999999993, + 69.48100000000022 + ], + "priority": 21, + "parents": [ + 145382 + ], + "children": [ + 145375 + ], + "area": 6703586.253975, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 145375, + "strid": "be5bbf55-7d65-4f27-b0bc-beb835c337fc", + "image_id": 206145, + "image_name": "18337.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1745.951, + 3925.427, + 1444.143, + 311.7760000000003 + ], + "priority": 22, + "parents": [ + 145366 + ], + "children": [], + "area": 6853603.196077, + "iscrowd": 0, + "segmentation": [], + "text": "[1] Lawrence M, Huber W, Pagés H, Aboyoun P, Carlson M, et al. (2013) Software for Computing and Annotating Genomic\nRanges. PLoS Comput Biol 9(8): e1003118. doi:10.1371/journal.pcbi.1003118 [2] King AD1, Huang K2, Rubbi L3, Liu $4,\nWang CY5, Wang Y4, Pellegrini M3, Fan G6 Reversible Regulation of Promoter and Enhancer Histone Landscape by DNA\nMethylation in Mouse Embryonic Stem Cells. Cell Rep. 2016 Sep 27;17(1):289-302. doi: 10.1016/j.celrep.2016.08.083. [3]\nStavrovskaya E, Niranjan T, Fertig E, Wheelan S, Favorov A, Mironov A (2017) StereoGene: rapid estimation of genome-wide\ncorrelation of continuous or interval feature data. Bioinformatics 33(20). doi:10.1093/bioinformatics/btx379. [4] Favorov A1,\nMularoni L, Cope LM, Medvedeva Y, Mironov AA, Makeev VJ, Wheelan SJ (2012) Exploring massive, genome scale datasets\nwith the GenometriCorr package. PLoS Comput Biol. 2012 May;8(5):e1002529. doi: 10.1371/journal.pcbi.1002529." + }, + { + "id": 136609, + "strid": "92423915-3208-4c74-8924-36d1c47c462f", + "image_id": 205798, + "image_name": "15956.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 814.24, + 14.06, + 325.70000000000005, + 294.2 + ], + "priority": -1, + "parents": [], + "children": [ + 136591, + 136596, + 136592, + 136589, + 136597, + 136590, + 136593, + 136595, + 136594 + ], + "area": 11448.2144, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 136589, + "strid": "7f0cd8af-b5a4-4312-98a6-11a496ea15eb", + "image_id": 205798, + "image_name": "15956.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 1219.215, + 62.348, + 3011.5469999999996, + 98.796 + ], + "priority": 1, + "parents": [ + 136609 + ], + "children": [], + "area": 76015.61682, + "iscrowd": 0, + "segmentation": [], + "text": "Can Diabetes Self-Management Program Reduce Diabetes Distress Among Patients?" + }, + { + "id": 136590, + "strid": "efaabfdf-020f-4857-b71c-835b67a8db01", + "image_id": 205798, + "image_name": "15956.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1422.045, + 254.338, + 2605.095, + 165.11499999999998 + ], + "priority": 2, + "parents": [ + 136609 + ], + "children": [], + "area": 361680.08121000003, + "iscrowd": 0, + "segmentation": [], + "text": "Raihan Khan, MPH; Ranjita Misra, PhD; Sijin Wen, PhD; Usha Sambamoorthi, PhD\nWest Vir ginia University, Morgantown, WV" + }, + { + "id": 136591, + "strid": "29296690-b1cd-4f55-9dc5-76cea45eef88", + "image_id": 205798, + "image_name": "15956.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 604.91, + 457.6, + 547.668, + 78.67600000000004 + ], + "priority": 3, + "parents": [ + 136609 + ], + "children": [ + 136598 + ], + "area": 276806.816, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 136598, + "strid": "980a5680-336c-4b19-95a6-f54612e7eeb4", + "image_id": 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"bbox": [ + 3999.591, + 3180.161, + 1144.8629999999998, + 81.50300000000016 + ], + "priority": 19, + "parents": [ + 136609 + ], + "children": [ + 136608 + ], + "area": 12719343.314151, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion and Conclusion" + }, + { + "id": 136608, + "strid": "f9c38768-0a4a-4cd4-a817-7d37c09736b4", + "image_id": 205798, + "image_name": "15956.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3718.427, + 3299.448, + 1787.042, + 160.5239999999999 + ], + "priority": 20, + "parents": [ + 136597 + ], + "children": [], + "area": 12268756.528296, + "iscrowd": 0, + "segmentation": [], + "text": "uFindings suggest that lifestyle self-management programs have the potential to reduce diabetes\ndistress among patients. In addition, it can provide valuable information to help health care\nproviders and patients identify interventions and coping strategies to improve diabetes outcomes." + }, + { + "id": 101032, + "strid": "c30240a4-27cb-44b8-a0eb-a14600c2a44a", + "image_id": 204404, + "image_name": "122059.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 1208.75, + 105.45, + 158.24, + 85.32000000000001 + ], + "priority": -1, + "parents": [], + "children": [ + 101000, + 101008, + 101003, + 101006, + 101004, + 101002, + 101009, + 101007, + 101001, + 101005 + ], + "area": 127462.6875, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 101000, + "strid": "f9e5a7c6-4cbf-4a4a-b262-f22d4d2bfdd7", + "image_id": 204404, + "image_name": "122059.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 43.091, + 44.664, + 1641.571, + 41.351 + ], + "priority": 1, + "parents": [ + 101032 + ], + "children": [], + "area": 1924.616424, + "iscrowd": 0, + "segmentation": [], + "text": "Effects of CNS-region-specific versus peripheral increased TNF on emotional behavior in mice" + }, + { + "id": 101001, + "strid": "d756218a-5f72-4622-9874-3b20d18ff581", + "image_id": 204404, + "image_name": "122059.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 43.265, + 104.096, + 1138.476, + 112.52199999999999 + ], + "priority": 2, + "parents": [ + 101032 + ], + "children": [], + "area": 4503.71344, + "iscrowd": 0, + "segmentation": [], + "text": "Federica Klaus’, Elisa Marzorati*, Hannes Sigrist’, Jean-Charles Paterna’, Erich Seifritz*, Christopher R. Pryce*\n\nMeee ery a or Decne AA co tec ame CI ae R auc Me Pn ec]\nROA ee ec |\n'Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland" + }, + { + "id": 101002, + "strid": "ab4629b7-2e1d-440f-bbef-ba069ff114ed", + "image_id": 204404, + "image_name": "122059.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 231.369, + 256.965, + 136.97299999999998, + 22.535000000000025 + ], + "priority": 3, + "parents": [ + 101032 + ], + "children": [ + 101010 + ], + "area": 59453.73508499999, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 101010, + "strid": "7fafc814-5d30-45d4-9f0a-f699e2a2de8d", + "image_id": 204404, + "image_name": "122059.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 35.288, + 293.736, + 529.467, + 220.409 + ], + "priority": 4, + "parents": [ + 101002 + ], + "children": [], + "area": 10365.355967999998, + "iscrowd": 0, + "segmentation": [], + "text": "High comorbidity of MOO (mejor depressive disorder’) and autoimmune disorders (0.9. miliple\nsclerosis) supports the growing clinical end experimental evidence that inflammatory processes\nmight play an important role in the aetio-pathophysiclogy of MDD, Several candidate mediators of\nthese effects are proposed, including increased levels of te pro-inflammatory oylokine tumor\nnecrosis factor aloha (TNF). Human evidence in suppor of the cytokine hypothesis includes:\nincreased blood levels of the pro-inflammatory cytokines, such as tumor necrosis factor (TNF) and\ninterleukin 6 (IL-6) in MDD patients compared to healthy controls, elatwvely high MDD comorbidity\nwith chronic inflammatory diseases including rheumatoid arthriis, multiple sclerosis and type-2\ndiabetes; and high prevalence of MDD in individuals undergoing chronic cytokine therapy”. The\nadministration of central and pergheral TNF in mice has been shown to effect sickness behavior\nand depression-elevant behavior’,\n\nThe focus of this study is the proinflammatory cytokine tumor necrosis factor (TNE). and the aim is\nto investigate the effects of increased TNF in specific brain regions versus the periphery on\ndepression-relevant behavior in male adult BLIS mice." + }, + { + "id": 101003, + "strid": "1cf96042-e52b-49f6-9ef0-d22da8c8bf6c", + "image_id": 204404, + "image_name": "122059.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 821.757, + 256.385, + 98.44799999999998, + 22.49000000000001 + ], + "priority": 5, + "parents": [ + 101032 + ], + "children": [ + 101024, + 101022, + 101026, + 101021, + 101029, + 101025, + 101023, + 101030 + ], + "area": 210686.168445, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 101021, + "strid": "ad078da2-0178-471b-83ac-8cd361122f1b", + "image_id": 204404, + "image_name": "122059.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 608.437, + 299.341, + 258.394, + 12.37299999999999 + ], + "priority": 6, + "parents": [ + 101003 + ], + "children": [], + "area": 182130.140017, + "iscrowd": 0, + "segmentation": [], + "text": "Fear Conditoning (Reactivity to aversive stimuli)" + }, + { + "id": 101026, + "strid": "9881258c-c037-4454-adaa-b1ba9bb91336", + "image_id": 204404, + "image_name": "122059.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 599.867, + 316.243, + 107.06299999999999, + 85.94200000000001 + ], + "priority": 7, + "parents": [ + 101003 + ], + "children": [], + "area": 189703.73968099998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 101025, + "strid": "3640c9a5-76c6-4b8f-b329-d0b9d875a477", + "image_id": 204404, + "image_name": "122059.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 710.219, + 328.159, + 204.79099999999994, + 78.88400000000001 + ], + "priority": 8, + "parents": [ + 101003 + ], + "children": [], + "area": 233064.75682100002, + "iscrowd": 0, + "segmentation": [], + "text": "An suditory concitoned sirulis\n(CS, 6x 20-496 tone) was patted win &\nshock (6x 0.200 x 0.2mA,TI 120880) on\nday 1, on day 2 a content test (21 x 60200}\nwas conducted followed by @ CS test (12 x\n30sec, 90sec IT!) in the same context." + }, + { + "id": 101022, + "strid": "fc419a0b-95d1-49b4-bb71-b63bc4fcb6d8", + "image_id": 204404, + "image_name": "122059.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 915.596, + 298.902, + 209.61899999999991, + 12.286000000000001 + ], + "priority": 9, + "parents": [ + 101003 + ], + "children": [], + "area": 273673.475592, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 101024, + "strid": "d54d59c8-7797-46f5-9e56-d1fcd8a38ec4", + "image_id": 204404, + "image_name": "122059.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 923.026, + 325.589, + 93.88999999999999, + 73.745 + ], + "priority": 10, + "parents": [ + 101003 + ], + "children": [], + "area": 300527.11231399997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 101023, + "strid": "cb423222-d501-460b-ba89-1a655840947f", + "image_id": 204404, + "image_name": "122059.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1022.312, + 328.107, + 92.81100000000004, + 50.363 + ], + "priority": 11, + "parents": [ + 101003 + ], + "children": [], + "area": 335427.723384, + "iscrowd": 0, + "segmentation": [], + "text": "choice Deawean &\nbottle win water oF\n0.05% encchadn." + }, + { + "id": 101029, + "strid": "bcdb40a6-2ec2-4bc2-9c4a-877a6bb2d3f6", + "image_id": 204404, + "image_name": "122059.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 612.089, + 425.625, + 532.948, + 105.71399999999994 + ], + "priority": 12, + "parents": [ + 101003 + ], + "children": [], + "area": 260520.38062500002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 101030, + "strid": "2adecbc2-a268-4540-8504-d3b5956eb06b", + "image_id": 204404, + "image_name": "122059.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 604.471, + 538.735, + 229.00199999999995, + 9.600999999999999 + ], + "priority": 13, + "parents": [ + 101003 + ], + "children": [], + "area": 325649.684185, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 101004, + "strid": "fc369576-12c2-4ca0-bc3b-0bee7a24460b", + "image_id": 204404, + "image_name": "122059.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1246.248, + 256.246, + 389.81899999999996, + 26.920000000000016 + ], + "priority": 14, + "parents": [ + 101032 + ], + "children": [ + 101031, + 101027, + 101028 + ], + "area": 319346.065008, + "iscrowd": 0, + "segmentation": [], + "text": "Blood-Brain-Barrier Crossing of TNF" + }, + { + "id": 101027, + "strid": "246c25c6-243b-42de-be9d-b65e93ec0f6c", + "image_id": 204404, + "image_name": "122059.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1185.03, + 298.191, + 96.7159999999999, + 11.690999999999974 + ], + "priority": 15, + "parents": [ + 101004 + ], + "children": [], + "area": 353365.28072999994, + "iscrowd": 0, + "segmentation": [], + "text": "TNF levels in brain" + }, + { + "id": 101028, + "strid": "63b9a2a7-411a-452b-a634-4bce1380c7e2", + "image_id": 204404, + "image_name": "122059.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1176.425, + 316.049, + 531.633, + 204.28999999999996 + ], + "priority": 16, + "parents": [ + 101004 + ], + "children": [], + "area": 371807.94482499996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 101031, + "strid": "ecbf1ad9-c0a0-4b52-918b-4bc63947ce00", + "image_id": 204404, + "image_name": "122059.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1198.105, + 523.237, + 481.174, + 26.883000000000038 + ], + "priority": 17, + "parents": [ + 101004 + ], + "children": [], + "area": 626892.865885, + "iscrowd": 0, + "segmentation": [], + "text": "Daly Lp. injection with human TH protein (low doseivehicie: Cdaye, high dose: Iday) er murine THE\n(40ng!g bodyweight: 6éays), Brain collection th after lest injection." + }, + { + "id": 101005, + "strid": "7fecbe6d-16ec-4434-af43-11e51538928f", + "image_id": 204404, + "image_name": "122059.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 56.591, + 593.24, + 488.17099999999994, + 26.315000000000055 + ], + "priority": 18, + "parents": [ + 101032 + ], + "children": [ + 101016, + 101017, + 101011 + ], + "area": 33572.04484, + "iscrowd": 0, + "segmentation": [], + "text": "AAV-TNF in Amygdala and Fear Conditioning" + }, + { + "id": 101016, + "strid": "1a1d3ef8-d0ad-48e7-ba56-4127d433ae22", + "image_id": 204404, + "image_name": "122059.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 42.79, + 630.364, + 91.41900000000001, + 144.11199999999997 + ], + "priority": 19, + "parents": [ + 101005 + ], + "children": [], + "area": 26973.275560000002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 101011, + "strid": "de2e185a-c246-4596-a200-5c0edf4f3e00", + "image_id": 204404, + "image_name": "122059.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 147.239, + 634.875, + 416.21399999999994, + 139.56500000000005 + ], + "priority": 20, + "parents": [ + 101005 + ], + "children": [], + "area": 93478.360125, + "iscrowd": 0, + "segmentation": [], + "text": "Ciatere amygdater injection of 1 |f recAAV-8/2-CMV-chimuine TNF-sipha ot\n1 fetOvgiml (AAV-TNF) and 14-day incubation led t9 significantly increased TNE\nprotein levels in Amygdala\n\nSignificant (Trial block: p<0.0005) and similar (Group: 9=0.63) acquisition of CS\ntreazing (% time spent treezing defined as >2sec inactivity) during CS conditioning\nin TNF-viral-vector injected animals compared to vehicie\n\nSignificant (Trial Block: p<0.0005) snc similsr (Group: 9=0.53) expression of fear to\ncontexl and inceaved expression af few to auditory condilioned stimulus (grava:\np<0.03) in .p. TNF injected animals compared to vehicle, indicating increased fear." + }, + { + "id": 101017, + "strid": "2dc7f217-2f60-4a79-9dd3-ff909496265c", + "image_id": 204404, + "image_name": "122059.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 40.642, + 793.988, + 530.83, + 170.92499999999995 + ], + "priority": 21, + "parents": [ + 101005 + ], + "children": [], + "area": 32269.260296000004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 101006, + "strid": "6e2a27b5-e119-4495-bfc9-752445ba47b2", + "image_id": 204404, + "image_name": "122059.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 608.506, + 593.242, + 523.4830000000001, + 27.517000000000053 + ], + "priority": 22, + "parents": [ + 101032 + ], + "children": [ + 101018, + 101019, + 101012 + ], + "area": 360991.31645199994, + "iscrowd": 0, + "segmentation": [], + "text": "Repeated peripheral TNF and Fear Conditioning" + }, + { + "id": 101018, + "strid": "f5788702-f562-420a-81e9-212ca995e060", + "image_id": 204404, + "image_name": "122059.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 609.453, + 646.085, + 128.16999999999996, + 127.11400000000003 + ], + "priority": 23, + "parents": [ + 101006 + ], + "children": [], + "area": 393758.441505, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 101012, + "strid": "e4c1bbf6-aa09-45a1-b1c2-7788274573f5", + "image_id": 204404, + "image_name": "122059.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 745.242, + 637.638, + 389.90100000000007, + 122.63 + ], + "priority": 24, + "parents": [ + 101006 + ], + "children": [], + "area": 475194.618396, + "iscrowd": 0, + "segmentation": [], + "text": "Daly ip. Byscten of mumme Tre\" Gang © Gays (ongy Seuywoym), ar\nconditioned freezing tested on days 4/5 of injection.\n\nSignificant (Trial block: p<0,0005) and similar (Group: p=0.40) acquistion of\nCS freezing (% time spent treazng datined as *2sec Inactivity) during CS\nconditioning.\nIncreased sxpression of fear to Context (group: p<0.04) and to aucliory\nconditioned stimulus (group: p<0,005) compared to vehicle, Indicating\nIncreased fear." + }, + { + "id": 101019, + "strid": "c17709be-cba2-4248-932f-7f6782c7dbf1", + "image_id": 204404, + "image_name": "122059.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 604.493, + 794.843, + 532.388, + 169.038 + ], + "priority": 25, + "parents": [ + 101006 + ], + "children": [], + "area": 480477.029599, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 101007, + "strid": "f4048b86-b931-400e-ad06-55f0f89697db", + "image_id": 204404, + "image_name": "122059.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1219.323, + 593.241, + 439.8410000000001, + 27.187000000000012 + ], + "priority": 26, + "parents": [ + 101032 + ], + "children": [ + 101020, + 101013 + ], + "area": 723352.395843, + "iscrowd": 0, + "segmentation": [], + "text": "TNF and Reactivity to Rewarding Stimuli" + }, + { + "id": 101013, + "strid": "1c63461d-651f-4dd8-aaf3-d331335035a7", + "image_id": 204404, + "image_name": "122059.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1177.995, + 639.179, + 528.345, + 139.00300000000004 + ], + "priority": 27, + "parents": [ + 101007 + ], + "children": [], + "area": 752949.666105, + "iscrowd": 0, + "segmentation": [], + "text": "Daity ip. injection of murine TNF during 6 days (40ng/g bodyweight), assessment of Water Consumption,\nSeccharin Consumption and Saccharin Preference (Saccharin/(Saccharins Water Consumption),\n\n \n\nTNF decreases significantly saccharin consumption compared to Baseline (B) during last 3 days of\ninjection and on first day after injacton (Day: p< 0.0005}, No effect of vahicle injection (Day: p=0.20),\nThere was no effect of group on water consumption (p=0.42) and saccharin proferance (p=0.90) (data not\nsnown).\n\nIncreased TNF levels in the Amygdala dd not alter Water Corsumpton, Saccharn Consummation and\nSaccharin Preference (data not shown)." + }, + { + "id": 101020, + "strid": "ddb78fb5-4144-47f8-aaea-6fb1d57adb8a", + "image_id": 204404, + "image_name": "122059.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1243.7, + 807.295, + 448.7049999999999, + 148.74400000000003 + ], + "priority": 28, + "parents": [ + 101007 + ], + "children": [], + "area": 1004032.7914999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 101008, + "strid": "91ba7235-b1f9-440f-ab5b-19de6f495d6f", + "image_id": 204404, + "image_name": "122059.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 239.515, + 1010.777, + 119.88499999999999, + 20.651000000000067 + ], + "priority": 29, + "parents": [ + 101032 + ], + "children": [ + 101015 + ], + "area": 242096.25315499998, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 101015, + "strid": "d6c012aa-801f-42be-a4fb-dcf68abf5d86", + "image_id": 204404, + "image_name": "122059.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 36.226, + 1050.077, + 528.627, + 135.35099999999989 + ], + "priority": 30, + "parents": [ + 101008 + ], + "children": [], + "area": 38040.089402, + "iscrowd": 0, + "segmentation": [], + "text": "Peripheral repeated increased TNF levels are sufficient to increase conditioned fear expression to\nContext and CS and decrease saccharin consumption in the presence of a marginal increaese of\nTNF in periventricular regions and without altering TNF levels in the Amygdala,\n\nCentrally increased TNF levels in the Amygdala are sufficient to increase conditioned fear\nexpression to CS without altering saccharin consumption.\n\nThese findings might be due to the fact that two independent processes induce the same behavioral\nchanges, or due to a common down-stream mediator induced by TNF with a different Blood-Brain-\nBarvier passage." + }, + { + "id": 101009, + "strid": "00aa5631-847c-4ddd-9d57-2eb889c3b67c", + "image_id": 204404, + "image_name": "122059.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 810.406, + 1011.032, + 120.83000000000004, + 22.059000000000083 + ], + "priority": 31, + "parents": [ + 101032 + ], + "children": [ + 101014 + ], + "area": 819346.398992, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 101014, + "strid": "504f0197-3abd-4e0e-8642-3a7e7442bd79", + "image_id": 204404, + "image_name": "122059.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 608.282, + 1050.73, + 528.205, + 127.39499999999998 + ], + "priority": 32, + "parents": [ + 101009 + ], + "children": [], + "area": 639140.14586, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 35158, + "strid": 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"priority": 2, + "parents": [ + 35158 + ], + "children": [], + "area": 77476.75521199999, + "iscrowd": 0, + "segmentation": [], + "text": "Igor D. Bacelar Marques, Raquel de Melo Silva, Cinthia SS a ele Luiz Sérgio Azevedo, William hal Elbio D’Amico and Elias David-Neto\n\nNate een Service and Hematology Division, Warsi of Sao Paulo School of Medicine, Sao Paulo, Nae 8" + }, + { + "id": 35143, + "strid": "4d6a50a0-b81d-42c9-9690-448b66e78a29", + "image_id": 201887, + "image_name": "117833.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 411.476, + 959.183, + 460.121, + 60.97900000000004 + ], + "priority": 3, + "parents": [ + 35158 + ], + "children": [ + 35151, + 35146, + 35142, + 35153, + 35154 + ], + "area": 394680.784108, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 35146, + "strid": "874e0362-7051-4acc-9eb4-171438f00cbf", + "image_id": 201887, + "image_name": "117833.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 125.819, + 1128.811, + 1032.655, + 618.45 + ], + "priority": 4, + "parents": [ + 35143 + ], + "children": [], + "area": 142025.871209, + "iscrowd": 0, + "segmentation": [], + "text": "Renal allograft recipients with\nthrombophilia are at higher risk for early\nallograft loss, microvascular occlusion and\nacute rejection, with major consequences\nfor allograft survival. The aim of the present\nstudy was to evaluate the prevalence of\nprothrombotic risk factors in patients\nawaiting renal transplantation and _ its\ncontribution to patient and_ transplant\noutcomes." + }, + { + "id": 35142, + "strid": "5e47762b-c2eb-4943-8fba-e6d6a257b01e", + "image_id": 201887, + "image_name": "117833.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 101.229, + 2068.527, + 1598.827, + 787.6840000000002 + ], + "priority": 5, + "parents": [ + 35143 + ], + "children": [ + 35155 + ], + "area": 209394.91968300001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 35155, + "strid": "a6d82679-0c8c-410b-ae21-f5072f0819bf", + "image_id": 201887, + "image_name": "117833.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 111.036, + 1977.077, + 1577.091, + 89.97099999999978 + ], + "priority": 6, + "parents": [ + 35142 + ], + "children": [], + "area": 219526.721772, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1. Baseline characteristics of the patients awaiting renal transplantation who\nunderwent laboratory screening for thrombophilia (n=156)." + }, + { + "id": 35153, + "strid": "e6fe65cc-6164-4c5a-8d69-46d72f06f09b", + "image_id": 201887, + "image_name": "117833.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 138.991, + 2889.23, + 902.9490000000001, + 37.47699999999986 + ], + "priority": 7, + "parents": [ + 35143 + ], + "children": [], + "area": 401576.96693000005, + "iscrowd": 0, + "segmentation": [], + "text": "Data are number (%) of patients, unless otherwise indicated." + }, + { + "id": 35151, + "strid": "ff10c744-02f5-4456-8de6-1539d4d2aef4", + "image_id": 201887, + "image_name": "117833.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 105.328, + 3068.045, + 1595.316, + 663.078 + ], + "priority": 8, + "parents": [ + 35143 + ], + "children": [ + 35152 + ], + "area": 323151.04376000003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 35152, + "strid": "b0a0cf33-b25c-42f6-9bab-9bf5e9142c1b", + "image_id": 201887, + "image_name": "117833.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 112.645, + 2973.08, + 1578.913, + 88.68600000000015 + ], + "priority": 9, + "parents": [ + 35151 + ], + "children": [], + "area": 334902.5966, + "iscrowd": 0, + "segmentation": [], + "text": "Table 2. Follow-up and outcome after transplaniation in patients with and without\nthrombophilic risk factors (n=30)." + }, + { + "id": 35154, + "strid": "f66bb996-541d-4572-b936-95a491562d68", + "image_id": 201887, + "image_name": "117833.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 135.829, + 3734.544, + 906.3600000000001, + 38.409999999999854 + ], + "priority": 10, + "parents": [ + 35143 + ], + "children": [], + "area": 507259.376976, + "iscrowd": 0, + "segmentation": [], + "text": "Data are number (%) of patients, unless otherwise indicated." + }, + { + "id": 35144, + "strid": "28f757cb-b340-4a54-b30d-ca033e7c47fa", + "image_id": 201887, + "image_name": "117833.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2176.51, + 959.756, + 369.30499999999984, + 59.93299999999999 + ], + "priority": 11, + "parents": [ + 35158 + ], + "children": [ + 35147 + ], + "area": 2088918.53156, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 35147, + "strid": "5e54cfd9-263c-445d-a41e-f98e38ace4ae", + "image_id": 201887, + "image_name": "117833.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1305.903, + 1129.997, + 2116.1269999999995, + 374.1099999999999 + ], + "priority": 12, + "parents": [ + 35144 + ], + "children": [], + "area": 1475666.4722910002, + "iscrowd": 0, + "segmentation": [], + "text": "All patients with a history of a thromboembolic event, early or recurrent vascular access\nthrombosis, family history of thrombosis, or multiple miscarriages were screened\nprospectively for inherited and acquired hypercoagulable disorders. Confirmatory tests\nwere the following: antithrombin Ill, protein C and protein S deficiencies, factor V and\nprothrombin gene mutations, and presence of antiphospholipid antibodies (lupus\nanticoagulant, anticardiolipin and beta-2-glycoprotein)." + }, + { + "id": 35145, + "strid": "d77389c8-2a52-4a84-9fd7-2f078826d0d0", + "image_id": 201887, + "image_name": "117833.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2477.653, + 1823.066, + 327.59400000000005, + 60.12799999999993 + ], + "priority": 13, + "parents": [ + 35158 + ], + "children": [ + 35148 + ], + "area": 4516924.9440979995, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 35148, + "strid": "60ff0d43-6395-43d1-a443-78bab19e899f", + "image_id": 201887, + "image_name": "117833.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1860.361, + 1997.734, + 1568.822, + 1770.554 + ], + "priority": 14, + "parents": [ + 35145 + ], + "children": [], + "area": 3716506.421974, + "iscrowd": 0, + "segmentation": [], + "text": "Baseline characteristics of the patients awaiting renal\ntransplantation who underwent laboratory screening _ for\nthrombophilia are showed in Table 1. Eighty-eight patients (56%)\nexhibited at least one prothrombotic laboratory parameter, besides\nof isolated hyperhomocysteinemia, which’ confirmed a\nthrombophilic state. Lupus anticoagulant, anticardiolipin and beta-\n2-glycoprotein was present in 30%, 18% and 13%, and\nantithrombin Ill, protein C and protein S deficiencies in 11%, 8%\nand 10%, respectively. Factor V Leiden mutation was present in\nonly one patient and prothrombin gene G20210 mutation was not\nfound. Among the 156 patients, 30 underwent renal\ntransplantation and were followed for a median of 199 days\n(range, 9 — 418). All patients were on triple immunosuppressive\nregimen compromising mycophenolate, tacrolimus and\nprednisone. Thrombophilia was identified in 16 (53%). There were\nno differences between the thrombophilia and non-thrombophilia\ngroups regarding age, gender, cause of ESRD, presence of\ndiabetes, systemic lupus erythematosus, previous transplants,\nhistory of thrombosis, use of deceased donors’ or\nimmunosuppressive protocol. Seventeen (57%) received\nperioperative anticoagulation with unfractionated heparin and 5\n(30%) of these patients developed perinephric hematomas. Three\npatients with thrombophilia developed thrombotic complications (2\nupper limbs deep-vein thrombosis and 1 allograft artery\nthrombosis) and 1 patient without thrombophilia developed\nallograft vein thrombosis. Follow-up and outcome after\ntransplantation in patients with and without thrombophilic risk\nfactors are depicted in Table 2." + }, + { + "id": 35150, + "strid": "6065eb56-2134-4a2c-a4ea-47f5f080328c", + "image_id": 201887, + "image_name": "117833.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 919.388, + 3988.079, + 523.4309999999999, + 60.38299999999981 + ], + "priority": 15, + "parents": [ + 35158 + ], + "children": [ + 35149 + ], + "area": 3666591.9756520004, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 35149, + "strid": "3a00c016-2eec-475b-8a70-88d5f14949e7", + "image_id": 201887, + "image_name": "117833.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 130.987, + 4181.173, + 2110.716, + 314.54299999999967 + ], + "priority": 16, + "parents": [ + 35150 + ], + "children": [], + "area": 547679.3077509999, + "iscrowd": 0, + "segmentation": [], + "text": "Prothrombotic risk factors, especially antiphospholipid antibodies, are highly prevalent in\npatients awaiting renal transplantation with a clinical or familial history suggestive of\nthrombophilia, including early and recurrent vascular access. failure. Despite pre-\ntransplant screening and perioperative treatment and/or monitoring, thrombotic and\nbleeding complications are still frequent and severe." + }, + { + "id": 35156, + "strid": "4b351156-060a-4538-9904-05e51c9fe265", + "image_id": 201887, + "image_name": "117833.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2669.599, + 3990.327, + 482.7359999999999, + 58.13500000000022 + ], + "priority": 17, + "parents": [ + 35158 + ], + "children": [ + 35157 + ], + "area": 10652572.968873002, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 35157, + "strid": "8fa88641-63d3-42c8-96d5-c3893229d8f3", + "image_id": 201887, + "image_name": "117833.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2408.183, + 4179.569, + 1015.5540000000001, + 357.1819999999998 + ], + "priority": 18, + "parents": [ + 35156 + ], + "children": [], + "area": 10065167.013127001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 31586, + "strid": "27adfe95-43e8-4516-9834-646f49f224a3", + "image_id": 201738, + "image_name": "117602.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 487.47, + 62.35, + 213.43999999999994, + 284.59 + ], + "priority": -1, + "parents": [], + "children": [ + 31573, + 31571, + 31569, + 31568, + 31567, + 31572, + 31570 + ], + "area": 30393.754500000003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 31567, + "strid": "a80a69b6-2856-42f0-88c3-e47be67b954d", + "image_id": 201738, + "image_name": "117602.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 792.208, + 209.995, + 1498.9409999999998, + 225.91700000000003 + ], + "priority": 1, + "parents": [ + 31586 + ], + "children": [], + "area": 166359.71896, + "iscrowd": 0, + "segmentation": [], + "text": "Gamma-band activity\nRole of Music Perception in the Brain" + }, + { + "id": 31568, + "strid": "09209559-242e-4134-876e-9941ac07f7f3", + "image_id": 201738, + "image_name": "117602.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 164.661, + 525.562, + 2983.539, + 243.84699999999998 + ], + "priority": 2, + "parents": [ + 31586 + ], + "children": [], + "area": 86539.564482, + "iscrowd": 0, + "segmentation": [], + "text": "Yuko Urakami*, Yoshikazu Washizawa**, Koki Kawamura**, Kazuko Hiyoshi**, Andrzej Cichocki**\n\nNational Rehabilitation Center for Persons with Disabilities, Japan* urakami-yuko@rehab.go.jp\nRIKEN Brain Science Institute Cichocki Laboratory for Advanced Brain Signal Processing, Japan**" + }, + { + "id": 31569, + "strid": "90526a46-c2fe-4825-87f3-e5f8fef55fc5", + "image_id": 201738, + "image_name": "117602.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1453.441, + 776.152, + 397.28099999999995, + 62.72900000000004 + ], + "priority": 3, + "parents": [ + 31586 + ], + "children": [ + 31575, + 31574 + ], + "area": 1128091.139032, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 31574, + "strid": "ff749d53-60d3-4f42-b7f5-c83a5e9c355b", + "image_id": 201738, + "image_name": "117602.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 19.109, + 869.77, + 1606.243, + 448.644 + ], + "priority": 4, + "parents": [ + 31569 + ], + "children": [], + "area": 16620.43493, + "iscrowd": 0, + "segmentation": [], + "text": "Music perception involves acoustic and auditory scene analysis, processing of interval\nrelations, of musical syntax and semantics, and activation of premotor representations of\nactions. In the “dorsal pathway’, neurons in the parietal and frontal areas respond with\nsimilar characteristics. The “ventral pathway” includes the uncinate fasciculus that conveys\nvisuo-auditory information to the prefrontal cortex (area 10) from the temporal lobe.\nPrevious studies have shown that the musicians’ brains show significantly higher\ninterdependency in the gamma band between distributed cortical areas as compared with\nnon-musicians while listening to music\n\nDesign & Procedure Meethc" + }, + { + "id": 31575, + "strid": "8338c98b-b317-4195-a5ed-70ad594257bb", + "image_id": 201738, + "image_name": "117602.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1697.438, + 874.688, + 1565.933, + 938.4400000000002 + ], + "priority": 5, + "parents": [ + 31569 + ], + "children": [], + "area": 1484728.649344, + "iscrowd": 0, + "segmentation": [], + "text": "Long-range synchrony in the gamma band contains more information in understanding\nhigher cognitive functioning and large-scale general cognitive integration. On the other\nhand, traumatic brain injured patients (TBI) frequently fail to maintain consistent goal-\ndirected behavior due to their impairments of sustained attention.The present study\naimed to clarify the time-spatial neural networks and the role of gamma-activity during\nmusic perception of 11 normal subjects and 11 traumatic brain injury patients using 60-\nch electroencephalography (EEG).\n\n.\n\n)\n\nParticipants listened to the music from ear-phone with eyes-closed sitting in a dark\nexperimental room. In three conditions; 1) resting state with eyes-closed (for | minute), 2)\nlistening to the music (for 2.5 minutes of melody part) and 3) imaging the music without\nstimulation, examinations were performed by recording with a 60-ch EEG using Morlet\nWavelet time-frequency analysis, and Root Mean Square (RMS) was calculated in each\nfrequency-band. Average values of RMS were indicated in topograph maps. For\nstatistical analysis one-side t-test and two analyses of variance (ANOVAs), one Groping\nfactor (musicians and non-musicians) and Condition (resting-state, listening-to music,.\nimaging the music) were performed on the RMS of gamma value." + }, + { + "id": 31570, + "strid": "b7ce1fba-9462-4f48-a81b-8c703aab2be5", + "image_id": 201738, + "image_name": "117602.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1430.033, + 1269.403, + 276.8710000000001, + 57.64200000000005 + ], + "priority": 6, + "parents": [ + 31586 + ], + "children": [ + 31576 + ], + "area": 1815288.1802989999, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 31576, + "strid": "7893cf6d-3755-431c-aaca-b4014b5d99ed", + "image_id": 201738, + "image_name": "117602.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 33.657, + 1352.956, + 1338.276, + 533.887 + ], + "priority": 7, + "parents": [ + 31570 + ], + "children": [], + "area": 45536.44009199999, + "iscrowd": 0, + "segmentation": [], + "text": "Music | : Anton Dvorak “From the New World Symphony”\nThe Symphony No. 9 in E Minor From the New World Largo D-flat major\n“Going home”\n\nMusic 2: Wolfgang Amadeus Mozart Requiem in D minor (K. 626)\nSequence “Dies irae”.\n\n11 normal subjects ;aged 21~25; 8 male, 2 female, 5 music-training students\n(musicians), 5 non music-training students (non-musicians) and one\nprofessional musician (singer) participated in this study.\n\n11 traumatic brain injury patients; aged 19 ~32; 9 male, 2 female, frontal\n\ncontusion and diffuse axonal injury remaining cognitive dysfunctions" + }, + { + "id": 31571, + "strid": "da8afedc-c891-43bb-ae5e-a03f8bf0b6c5", + "image_id": 201738, + "image_name": "117602.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1418.704, + 1788.219, + 230.53700000000003, + 60.2650000000001 + ], + "priority": 8, + "parents": [ + 31586 + ], + "children": [ + 31581, + 31580, + 31585, + 31583, + 31578, + 31584, + 31582, + 31579 + ], + "area": 2536953.448176, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 31585, + "strid": "5b2e5f99-00c8-41b3-b82d-1e20577adf65", + "image_id": 201738, + "image_name": "117602.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 20.351, + 1881.42, + 3109.427, + 989.6530000000002 + ], + "priority": 9, + "parents": [ + 31571 + ], + "children": [], + "area": 38288.77842, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 31584, + "strid": "1ceb0877-1470-4fac-99db-146d21cf6f96", + "image_id": 201738, + "image_name": "117602.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 12.689, + 2886.397, + 1545.774, + 258.587 + ], + "priority": 10, + "parents": [ + 31571 + ], + "children": [], + "area": 36625.491533, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 31583, + "strid": "459c5cf8-bcfb-4e3a-86f0-2415f4e63019", + "image_id": 201738, + "image_name": "117602.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 52.579, + 3169.213, + 1433.18, + 481.3899999999999 + ], + "priority": 11, + "parents": [ + 31571 + ], + "children": [], + "area": 166634.050327, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 31580, + "strid": "7d91200f-eb9e-4b30-b237-ab5ca6dc96c4", + "image_id": 201738, + "image_name": "117602.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 39.146, + 3653.411, + 649.294, + 204.71000000000004 + ], + "priority": 12, + "parents": [ + 31571 + ], + "children": [], + "area": 143016.427006, + "iscrowd": 0, + "segmentation": [], + "text": "The RMS ratio of gamma activity of\nresting-state and music-listening\n(Music1) of normal subjects and TBI\n\npatients af." + }, + { + "id": 31581, + "strid": "2d99233c-2981-43ab-b331-890e59013abc", + "image_id": 201738, + "image_name": "117602.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 824.076, + 3652.155, + 538.7759999999998, + 100.471 + ], + "priority": 13, + "parents": [ + 31571 + ], + "children": [], + "area": 3009653.28378, + "iscrowd": 0, + "segmentation": [], + "text": "The RMS ratio of resting-state\nand music-listening(Music2)" + }, + { + "id": 31579, + "strid": "703fc9ae-7225-4b3a-bc9f-f115db634b95", + "image_id": 201738, + "image_name": "117602.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1594.524, + 2887.548, + 1616.9360000000001, + 663.73 + ], + "priority": 14, + "parents": [ + 31571 + ], + "children": [], + "area": 4604264.587152, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 31582, + "strid": "406eb7f0-e41d-4ac9-94e7-ccefd54c42e8", + "image_id": 201738, + "image_name": "117602.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1282.389, + 3690.082, + 651.789, + 668.4069999999997 + ], + "priority": 15, + "parents": [ + 31571 + ], + "children": [], + "area": 4732120.565897999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 31578, + "strid": "6e32d5ad-021d-4fe7-ae02-ec9e7f2da7d9", + "image_id": 201738, + "image_name": "117602.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1927.422, + 3567.82, + 1323.324, + 793.9940000000001 + ], + "priority": 16, + "parents": [ + 31571 + ], + "children": [], + "area": 6876694.76004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 31572, + "strid": "4e5556ca-894f-4caf-af08-4cdbd1444cd9", + "image_id": 201738, + "image_name": "117602.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 619.173, + 3839.706, + 331.33400000000006, + 58.81700000000001 + ], + "priority": 17, + "parents": [ + 31586 + ], + "children": [ + 31577 + ], + "area": 2377442.283138, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion" + }, + { + "id": 31577, + "strid": "4efc42f6-7d34-4805-a1c2-7d335e6a0fac", + "image_id": 201738, + "image_name": "117602.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 130.431, + 3946.456, + 1089.013, + 446.3739999999998 + ], + "priority": 18, + "parents": [ + 31572 + ], + "children": [], + "area": 514740.20253600006, + "iscrowd": 0, + "segmentation": [], + "text": "The prefrontal cortex that contains Broca’s area and the posterior\n\nassociation area that contains Wernicke’s area are interconnected with a\nvariety of long and short association fibers. The ventral part of the frontal\nlobe and the temporal pole are also interconnected, both of which have\nreciprocal connections with the amygdala. Thus, integration of\nrecognition (logos) and emotion (pathos) occurs in the prefrontal cortex.\nA gamma-activity decreases during music perception especially in the\nanterior part of frontal lobe; it is strongly related to the integration of\nrecognition and emotion which reflect the processing of music in a highly\nintegrated consciousness level" + }, + { + "id": 31573, + "strid": "ba6c4cce-40cb-4319-90d2-ad627662d5bd", + "image_id": 201738, + "image_name": "117602.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1385.069, + 4358.963, + 578.8690000000001, + 74.42600000000039 + ], + "priority": 19, + "parents": [ + 31586 + ], + "children": [], + "area": 6037464.5234469995, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgement" + }, + { + "id": 148160, + "strid": "c42705f8-e5bf-4e0f-b1f9-120576927d34", + "image_id": 206252, + "image_name": "19210.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 1049.79, + 15.01, + 55.38000000000011, + 37.47 + ], + "priority": -1, + "parents": [], + "children": [ + 148154, + 148155, + 148152, + 148153, + 148144, + 148143 + ], + "area": 15757.347899999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 148143, + "strid": "112ee010-9045-45bd-b7cb-0802270ba4da", + "image_id": 206252, + "image_name": "19210.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 29.267, + 4.616, + 998.318, + 61.135000000000005 + ], + "priority": 1, + "parents": [ + 148160 + ], + "children": [], + "area": 135.09647199999998, + "iscrowd": 0, + "segmentation": [], + "text": "Transcriptome-wide identification and characterization of NRT/NPF gene family\nand their response to abiotic stress in Tectona grandis" + }, + { + "id": 148144, + "strid": "29e68ad5-ab5c-4291-b30b-9237eed27c21", + "image_id": 206252, + "image_name": "19210.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 63.655, + 69.269, + 929.263, + 42.32900000000001 + ], + "priority": 2, + "parents": [ + 148160 + ], + "children": [], + "area": 4409.318195000001, + "iscrowd": 0, + "segmentation": [], + "text": "Maheswari Patturaj’, Nithishkumar Kannan\", Balasubramanian Aiyar' and Ramasamy Yasodha\"*\n‘Institute of Forest Genetics and Tree Breeding, Coimbatore 641002, India *Corresponding author: E-mail: yasodha@icfre.org" + }, + { + "id": 148153, + "strid": "baefd20f-5807-438c-88af-74bc38010855", + "image_id": 206252, + "image_name": "19210.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 8.466, + 128.213, + 77.561, + 11.38900000000001 + ], + "priority": 3, + "parents": [ + 148160 + ], + "children": [ + 148157 + ], + "area": 1085.4512579999998, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 148157, + "strid": "fe3f8b49-d3c0-4075-bd3f-236d222df061", + "image_id": 206252, + "image_name": "19210.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 8.25, + 141.449, + 1317.313, + 57.977000000000004 + ], + "priority": 4, + "parents": [ + 148153 + ], + "children": [], + "area": 1166.95425, + "iscrowd": 0, + "segmentation": [], + "text": "litrate (NO,) is the preferred nitrogen source of higher plants that plays a crucial role in determining plant growth and productivity. Nitrate transporters (NRTs) participate in nitrate uptake, assimilation, transport and allocation processes that are within the plant.\nPlants have evolved two NO,” absorption systems to manage the heterogeneity of NO,, inthe soil, namely a low-affinity transport sy\n\n \n\nsm (LATS), and a high-affinity transport system (HATS), which are mediated by nitrate transporter 1 (NRT) and nitrate transporter 2\n(NRT2), respectively. NRT/PEPTIDE TRANSPORTER (PTR) family (NPF) genes, initially characterized as nitrate or peptide transporters in plants, are involved in the transport of a large variety of substrates, including amino acids, nitrate, auxin (IAA), jasmonates\n(JAs), abscisic acid (ABA) and gibberellins (GAs) and glucosinolates." + }, + { + "id": 148154, + "strid": "436d9094-93e5-4d2f-8bd6-0175d69b4547", + "image_id": 206252, + "image_name": "19210.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 8.668, + 206.363, + 56.65, + 15.107 + ], + "priority": 5, + "parents": [ + 148160 + ], + "children": [ + 148158 + ], + "area": 1788.7544839999998, + "iscrowd": 0, + "segmentation": [], + "text": "Objective" + }, + { + "id": 148158, + "strid": "be7b54bd-f1ce-4d91-8559-10ad33a22a67", + "image_id": 206252, + "image_name": "19210.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 8.454, + 221.133, + 797.18, + 54.77200000000002 + ], + "priority": 6, + "parents": [ + 148154 + ], + "children": [], + "area": 1869.4583820000003, + "iscrowd": 0, + "segmentation": [], + "text": "A comprehensive analysis NO3- transporter (NRT/NPF) gene family of T. grandis is presented in terms of phylogeny, cis-elements and motif analysis. The\nexpression patter of differentially expressed genes (DEGs) of NRT was analysed from seven transeriptomie dataset of T. grandis that grown under varying\nclimatic conditions such as semi moist areas (1201-1600 mm in rainfall, TNAGo2, TSNL23, T51 and TATR2) and very moist areas (2500 mm< in rainfall, TTEo9,\nTDAg and TDE7)." + }, + { + "id": 148155, + "strid": "dd119e78-1a8f-4c92-ad3e-b9f4be7c1c10", + "image_id": 206252, + "image_name": "19210.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 9.463, + 283.089, + 45.122, + 12.920000000000016 + ], + "priority": 7, + "parents": [ + 148160 + ], + "children": [ + 148147, + 148159, + 148151, + 148148 + ], + "area": 2678.8712069999997, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 148159, + "strid": "81edd3b9-3b42-417f-93eb-c3c54f187f6a", + "image_id": 206252, + "image_name": "19210.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 8.435, + 297.133, + 798.541, + 95.137 + ], + "priority": 8, + "parents": [ + 148155 + ], + "children": [], + "area": 2506.316855, + "iscrowd": 0, + "segmentation": [], + "text": "A tts] of 73 NET:1/PTR (as known as NPF) and 5 NET2 genes have been identified from the transcriptome dataset of Teak sssembied against the chromosomes\nin accordance with the whole genome of this species (htips://datadryad org/stash dataset/doisi0.5061/deyad.77b2422), Non-redundant peptide sequences of\nNRTi/PTR and NRT» gene family were retrieved from Populus trichocarpa. v3.0 for comparative phylogenetic analysis. NRT3/PTR and NRT2 genes have been\nidentified in P.trichocarpa and T. grandis are classified into eight subfamilies. NPF orthologues from in P. trichocarpa were located together with T. grandis\nNDF members in the same clades representing the eight subfamilies (NPFI-NPF8). Among the NPF gene family, the NPFS subfamily contains the most (52\nmembers) NPF genes, followed by subfamilies NPF4 (20 members), NPF2 (x7 members), NPF8 and NPF (14 and 13 members for each subfamily), NPF6 (12\nmembers), NPF2 (11 members), NPF7 (7 members) and NPF3 (6 members) with the least NPF genes." + }, + { + "id": 148148, + "strid": "beb188a2-83b1-4bd7-ba73-ec5ac36ff8a4", + "image_id": 206252, + "image_name": "19210.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 13.208, + 454.473, + 301.11, + 293.07599999999996 + ], + "priority": 9, + "parents": [ + 148155 + ], + "children": [ + 148149 + ], + "area": 6002.679384, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 148149, + "strid": "162f2e98-28c0-4397-8908-c3e791d51f1b", + "image_id": 206252, + "image_name": "19210.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 14.697, + 408.411, + 292.155, + 35.68000000000001 + ], + "priority": 10, + "parents": [ + 148148 + ], + "children": [], + "area": 6002.416467, + "iscrowd": 0, + "segmentation": [], + "text": "Fig 1, Exon—intron structere represented in kilobase (kb) scale\nof 78 TgNPF/NRT genes and Schematic representation of the\nconserved motifs in the NPE/NRT proteins from Teak." + }, + { + "id": 148151, + "strid": "cc5cf52a-f551-481b-9a54-50fe393f8e2f", + "image_id": 206252, + "image_name": "19210.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 319.471, + 398.115, + 554.843, + 352.49 + ], + "priority": 11, + "parents": [ + 148155 + ], + "children": [ + 148146, + 148150 + ], + "area": 127186.197165, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 148150, + "strid": "abbc0914-5204-40db-9636-3b52a52e66d9", + "image_id": 206252, + "image_name": "19210.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 326.029, + 408.613, + 213.72900000000004, + 35.831999999999994 + ], + "priority": 12, + "parents": [ + 148151 + ], + "children": [], + "area": 133219.68777699998, + "iscrowd": 0, + "segmentation": [], + "text": "Fig 2. Cle-acting reguistory elemente in the\npromoter regions of candidate TgNPE/NRT\ntrenes," + }, + { + "id": 148146, + "strid": "6ce5497c-5d45-4640-838f-6466fd28ff99", + "image_id": 206252, + "image_name": "19210.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 884.941, + 403.334, + 410.4179999999999, + 149.06299999999993 + ], + "priority": 13, + "parents": [ + 148151 + ], + "children": [], + "area": 356926.79329400003, + "iscrowd": 0, + "segmentation": [], + "text": "Fig 4. Maximum-likelihood phylogenetic tree rooted of T. grandis NRT\nfamily proteins were clustered into two major elades: NPF with seven subclades\nand NRT2. T. grandis NPF/NRT sequences were retrieved from the transcriptome\ndata and then manually curated to select unique sequences. Multiple alignment of\nthe peptide sequences between Populus and T. grandis from the resulting 152\nsequences was performed using the MAFFT, and the phylogenetic tree was\nconstructed using 1Q-Tree v1.6.9 and ultrafast bootstrap, with 1000 replicates, The\nresulting 9 NRT families are indicated by colored sections and family name\nacronyms. Members of 7 grandis (78) and P. trichocarpa (74) NPF/NRT2 protein\nfamily were denoted with purple and blue letters, respectively. Bootstrap values\nare described in the branch points." + }, + { + "id": 148147, + "strid": "5d34ed8b-d478-418e-8884-794e542d373f", + "image_id": 206252, + "image_name": "19210.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 814.676, + 194.4, + 238.9799999999999, + 201.751 + ], + "priority": 14, + "parents": [ + 148155 + ], + "children": [ + 148145 + ], + "area": 158373.01440000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 148145, + "strid": "068c29bc-8783-4280-8f24-c15ec7fe0b68", + "image_id": 206252, + "image_name": "19210.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1061.802, + 210.715, + 263.6600000000001, + 161.352 + ], + "priority": 15, + "parents": [ + 148147 + ], + "children": [], + "area": 223737.60843, + "iscrowd": 0, + "segmentation": [], + "text": "Mig 3. Hierarchical clustering of ineilico expression\nprofiles of differentially expressed TgNPF/NRT genes\nfrom diverse geographical location of . grandis, Lgatthmic\nof odds fold change Is sett 2 and FDR 0.05 was used asthe\nthreshold to identify significant differences in expression\nbetween diferent conditions. The 16 genes were clustered into\n4 groups. The samples from diferent locations (TTEOS,\nTDA, TDE7, TNAGo2, TSNLzg, T51 and TATR2 wer\nclustered according tothe amount of rainfall (mim) in\nparticular location. The color scale on the left-hand side\nrepresents transcript per million (TPM). Gene expression\nvalues foreach gene were transformed using Z-sotes. Higher\nexpression levels are represented. in blue, and_ lower\ncapression levels are denoted in yellow." + }, + { + "id": 148152, + "strid": "b5c490d0-859f-4319-b927-2c82d6eae564", + "image_id": 206252, + "image_name": "19210.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 881.408, + 586.197, + 90.24800000000005, + 14.754000000000019 + ], + "priority": 16, + "parents": [ + 148160 + ], + "children": [ + 148156 + ], + "area": 516678.725376, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 148156, + "strid": "8d719cf6-68cd-4341-b993-72dae64da069", + "image_id": 206252, + "image_name": "19210.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 880.874, + 602.548, + 416.0150000000001, + 69.46900000000005 + ], + "priority": 17, + "parents": [ + 148152 + ], + "children": [], + "area": 530768.8669520001, + "iscrowd": 0, + "segmentation": [], + "text": "In this study, 78 TgNPF/NRTs members were identified that divided into 9\nsubfamilies having conserved gene and protein structure within each subfamily oF\nclade. In summary, results reveal that expression of TgNPF/NRT may be regulated\nby various kinds of hormones and abiotic stresses. NPF4 subfamily is mainly\ninvolved in abscisic acid transportation, which need to be further characterized." + }, + { + "id": 122469, + "strid": "93391baa-d58c-4822-a67b-3ccf233778ed", + "image_id": 205267, + "image_name": "14562.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 42.74, + 244.45, + 301.9, + 396.24000000000007 + ], + "priority": -1, + "parents": [], + "children": [ + 122450, + 122449, + 122461, + 122446, + 122445, + 122447, + 122453, + 122466, + 122448 + ], + "area": 10447.793, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 122445, + "strid": "37cd3f01-2dab-41f6-bcd7-f58b226ddb0d", + "image_id": 205267, + "image_name": "14562.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 133.362, + 118.651, + 2181.934, + 380.65 + ], + "priority": 1, + "parents": [ + 122469 + ], + "children": [], + "area": 15823.534661999998, + "iscrowd": 0, + "segmentation": [], + "text": "Social support systems among asylum\nseekers in a mental health care programme,\nLesvos Island, Greece" + }, + { + "id": 122450, + "strid": "35f74788-3815-438a-869c-c2c596c78766", + "image_id": 205267, + "image_name": "14562.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 135.637, + 570.321, + 2201.344, + 272.09299999999996 + ], + "priority": 2, + "parents": [ + 122469 + ], + "children": [], + "area": 77356.62947700001, + "iscrowd": 0, + "segmentation": [], + "text": "Maria Episkopou', Emilie Venables?*, Katie Whitehouse?, Christos Eleftherakos', Federica Zamatto4,\n\nFrancisco de Bartolome Gisbert*, Nathalie Severy®, Declan Barry', Rafael Van den Bergh?\n\n‘Médecins Sans Frontiéres-Operational Centre Brussels, Athens, Greece, 7Médecins Sans Frontiéres-Operational Centre Brussels, Luxembourg\nOperational Research Unit, Luxembourg, Luxembourg, $Division of Social and Behavioural Sciences, School of Public Health and Family Medicine,\nUniversity of Cape Town, Cape Town, South Africa, ‘Medical Department, Médecins Sans Frontiéres-Operational Centre Brussels, Rome, Italy, Medical\nDepartment, Médecins Sans Frontiéres-Operational Centre Brussels, Brussels, Belgium." + }, + { + "id": 122446, + "strid": "69f4996a-58e5-4900-bc6d-5d7b06473d98", + "image_id": 205267, + "image_name": "14562.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 137.696, + 969.454, + 439.586, + 71.97700000000009 + ], + "priority": 3, + "parents": [ + 122469 + ], + "children": [ + 122451 + ], + "area": 133489.937984, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 122451, + "strid": "497e58f4-7237-4f94-8f5b-30db1da82d80", + "image_id": 205267, + "image_name": "14562.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 139.028, + 1056.292, + 706.12, + 1044.973 + ], + "priority": 4, + "parents": [ + 122446 + ], + "children": [], + "area": 146854.164176, + "iscrowd": 0, + "segmentation": [], + "text": "MSF has provided medical and\nmental health services to migrants\nand asylum seekers on Lesvos\nIsland, Greece since 2015.\nFollowing the EU-Turkey statement,\nnew arrivals on Lesvos are held on\nthe island, most of them in Moria\ncamp, until their legal or\nadministrative processes have\nbeen completed.\n\nMSF has been overwhelmed by the\nchallenges of delivering mental health\ncare, which has been exacerbated by\ncompromised social support.\n\nWe conducted this study to explore\nhow migrants and asylum seekers\nunderstood and defined social\nsupport, and how they perceived their\nneeds to be met." + }, + { + "id": 122448, + "strid": "6f41ad4c-0e0b-431d-9178-e730360e080b", + "image_id": 205267, + "image_name": "14562.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 135.204, + 2202.011, + 316.477, + 73.19999999999982 + ], + "priority": 5, + "parents": [ + 122469 + ], + "children": [ + 122465, + 122458 + ], + "area": 297720.695244, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 122458, + "strid": "4a5998ff-68b2-48cd-bea1-cddfa58ae85d", + "image_id": 205267, + "image_name": "14562.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 136.875, + 2292.531, + 711.556, + 794.0329999999999 + ], + "priority": 6, + "parents": [ + 122448 + ], + "children": [], + "area": 313790.180625, + "iscrowd": 0, + "segmentation": [], + "text": "This qualitative study with migrants\nand asylum seekers incorporated\nsequentially conducted free-listing\ninterviews (n=31) and in-depth\ninterviews (n=17) with participants\nenrolled in MSF’s mental health\nprogramme on Lesvos Island, Greece.\n\nConvenience sampling was used to\nrecruit participants. All interviews were\nconducted in English, French, Farsi\nand Arabic and were analysed using a\nthematic approach. Free-listing\ninvolved asking study participants to\ndefine ‘social support’ in their\n\nown words." + }, + { + "id": 122465, + "strid": "ec6ae3d3-56f6-47ed-8994-f3106baf6e41", + "image_id": 205267, + "image_name": "14562.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 123.516, + 3111.871, + 732.27, + 787.0889999999999 + ], + "priority": 7, + "parents": [ + 122448 + ], + "children": [ + 122457 + ], + "area": 384365.858436, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 122457, + "strid": "35027766-5f10-41e0-8cfc-14ace5930471", + "image_id": 205267, + "image_name": "14562.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 129.397, + 3905.031, + 668.02, + 38.68600000000015 + ], + "priority": 8, + "parents": [ + 122465 + ], + "children": [], + "area": 505299.296307, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1: Participant demographic characteristics" + }, + { + "id": 122466, + "strid": "d23204eb-724e-4e72-8545-2c959e5fbdd5", + "image_id": 205267, + "image_name": "14562.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 192.611, + 4032.815, + 542.404, + 454.0179999999996 + ], + "priority": 9, + "parents": [ + 122469 + ], + "children": [], + "area": 776764.529965, + "iscrowd": 0, + "segmentation": [], + "text": "During the free-listing\nexercise, participants\ncreated lists of the\nforms of social\nsupport that were\nmost important\n\nto them." + }, + { + "id": 122447, + "strid": "6920c1de-334d-46cf-86ea-cd3916921e9d", + "image_id": 205267, + "image_name": "14562.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 922.1, + 973.951, + 273.85900000000004, + 67.0340000000001 + ], + "priority": 10, + "parents": [ + 122469 + ], + "children": [ + 122452, + 122463, + 122455, + 122459, + 122460, + 122467, + 122464, + 122462 + ], + "area": 898080.2171, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 122452, + "strid": "77206810-2a8c-4b8c-98c4-2fe47d472395", + "image_id": 205267, + "image_name": "14562.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 929.802, + 1073.608, + 1388.319, + 200.2829999999999 + ], + "priority": 11, + "parents": [ + 122447 + ], + "children": [], + "area": 998242.865616, + "iscrowd": 0, + "segmentation": [], + "text": "Free-listing interviews defined social support as practical, informational,\nemotional support, meaning-making and informational support. The\nimportance of actors such as NGOs, friends, family and community were\nunderlined as sources of social support." + }, + { + "id": 122455, + "strid": "bd2ac845-81a8-41e4-adc6-726b121138f6", + "image_id": 205267, + "image_name": "14562.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 972.559, + 1314.515, + 1396.95, + 994.345 + ], + "priority": 12, + "parents": [ + 122447 + ], + "children": [ + 122456 + ], + "area": 1278443.3938850001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 122456, + "strid": "4180ab40-df96-4d8a-8386-421f5d06cf75", + "image_id": 205267, + "image_name": "14562.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 929.867, + 2330.187, + 1448.6740000000002, + 37.60199999999986 + ], + "priority": 13, + "parents": [ + 122455 + ], + "children": [], + "area": 2166763.995129, + "iscrowd": 0, + "segmentation": [], + "text": "Table 2: Categorization of the responses from the free-listing interviews in terms of forms of social support" + }, + { + "id": 122459, + "strid": "9e11ad88-4f2a-43ac-8738-b46b56b1f854", + "image_id": 205267, + "image_name": "14562.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 944.941, + 2417.351, + 1464.41, + 349.73 + ], + "priority": 14, + "parents": [ + 122447 + ], + "children": [], + "area": 2284254.071291, + "iscrowd": 0, + "segmentation": [], + "text": "Theme 1: availability and accessibility of services\n\nParticipants stressed how poor quality services and the barriers to accessing\ncertain types of formal social support within and outside the camp had a\nnegative influence on their lives. Discussions involved the problems created by\nthe lack of formal information and orientation about available services (including\nmedical and legal assistance), their rights and the procedures. Language was\nalso a challenge for those trying to access services." + }, + { + "id": 122462, + "strid": "ed6aab91-531f-4276-9c53-272860f16699", + "image_id": 205267, + "image_name": "14562.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 938.085, + 2832.656, + 1454.192, + 324.375 + ], + "priority": 15, + "parents": [ + 122447 + ], + "children": [], + "area": 2657272.10376, + "iscrowd": 0, + "segmentation": [], + "text": "At the beginning | didn’t know who to speak to. | didn’t\nknow that | needed a lawyer. Some people told me that\nthere are lawyers here and | visited one of them, it was\nvery difficult. | contacted five lawyers but it was still\n\ndifficult to have an appointment. 5, Male, 18, Afghanistan" + }, + { + "id": 122463, + "strid": "5f395fbd-65fa-437d-9ace-1e603ef8fd6a", + "image_id": 205267, + "image_name": "14562.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 939.66, + 3236.934, + 1485.2910000000002, + 237.70800000000008 + ], + "priority": 16, + "parents": [ + 122447 + ], + "children": [], + "area": 3041617.40244, + "iscrowd": 0, + "segmentation": [], + "text": "The social assistant is polite but the problem is that we\ndon’t understand each other. She speaks and | don’t\nunderstand, | speak and she doesn’t understand. 55\n\nFemale, 20, Cameroon" + }, + { + "id": 122460, + "strid": "8bc67c98-db7c-457a-9ecf-5cc9d1adcad0", + "image_id": 205267, + "image_name": "14562.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 945.158, + 3502.228, + 1468.9480000000003, + 292.9209999999998 + ], + "priority": 17, + "parents": [ + 122447 + ], + "children": [], + "area": 3310158.812024, + "iscrowd": 0, + "segmentation": [], + "text": "Theme 2: personal relationships and informal networks\n\nFeelings of isolation, exclusion and stigmatisation were described. Sometimes\nthis was linked to their mental health problems, with others described spending\ntime on their own. Differences between nationalities and heterogeneity amongst\npeople from the same country of origin caused tensions that did not foster a\nsense of cohesion." + }, + { + "id": 122464, + "strid": "7728604d-02ee-4c5f-9df8-fb621cf75319", + "image_id": 205267, + "image_name": "14562.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 940.703, + 3872.437, + 1479.063, + 255.39199999999983 + ], + "priority": 18, + "parents": [ + 122447 + ], + "children": [], + "area": 3642813.1032109996, + "iscrowd": 0, + "segmentation": [], + "text": "| don’t know people there. They tell me that | often wet\nthe bed, | often scream during the night, that’s what\nthey say. They also say that I’m crazy, that I’m out of\nmy mind. 79 Male, 42, DRC" + }, + { + "id": 122467, + "strid": "22d12ccd-e4fe-40ab-a362-82342324cdcf", + "image_id": 205267, + "image_name": "14562.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 927.813, + 4212.411, + 1503.9569999999999, + 319.4279999999999 + ], + "priority": 19, + "parents": [ + 122447 + ], + "children": [], + "area": 3908329.687143, + "iscrowd": 0, + "segmentation": [], + "text": "Every day we have problems with each other. We are\nvery different from each other. We are not like [other\nnationalities] who are similar to each other. Among\n[ourselves] here we have people from different\neconomic, cultural and social ranks. ays Male, 32, Iran" + }, + { + "id": 122453, + "strid": "a75ca2e0-39ed-4648-80e6-5a064e58c07f", + "image_id": 205267, + "image_name": "14562.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2551.36, + 660.126, + 530.498, + 600.502 + ], + "priority": 20, + "parents": [ + 122469 + ], + "children": [], + "area": 1684219.07136, + "iscrowd": 0, + "segmentation": [], + "text": "Social support helps\nyou endure or\novercome difficult\nsituations in your life.\nWhat people\nunderstand as social\nsupport is different\nbecause of their\nvarying experiences." + }, + { + "id": 122449, + "strid": "1eed094b-8557-4651-a745-8d33123dd467", + "image_id": 205267, + "image_name": "14562.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2494.48, + 1438.187, + 460.5149999999999, + 71.79300000000012 + ], + "priority": 21, + "parents": [ + 122469 + ], + "children": [ + 122468, + 122454 + ], + "area": 3587528.7077599997, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 122454, + "strid": "13dcde4c-a9d4-40fd-b048-69ac9da4949e", + "image_id": 205267, + "image_name": "14562.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2501.806, + 1530.105, + 694.627, + 1096.8979999999997 + ], + "priority": 22, + "parents": [ + 122449 + ], + "children": [], + "area": 3828025.86963, + "iscrowd": 0, + "segmentation": [], + "text": "The multidimensional challenges that\nparticipants face on Lesvos include\npoor service provision, lack of\ncommunity and challenges with\npersonal relationships. These lead\nto and amplify isolation,\ndiscrimination and tensions.\n\nMigrants and asylum seekers in the\ncamp have varied needs which often\nremain unmet. Increasing the\ncapacity of services could reduce\ntensions and competition for\n\nscarce resources.\n\nActors involved in providing social\nsupport, including MSF, are strongly\nencouraged to engage in activities\nthat work towards building and\nstrengthening peer support\nnetworks, creating community\nsupport rather than top down support." + }, + { + "id": 122468, + "strid": "93808bd6-30b3-4bd5-974f-b51ee4b23fbf", + "image_id": 205267, + "image_name": "14562.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2458.512, + 2659.744, + 770.2849999999999, + 941.7829999999999 + ], + "priority": 23, + "parents": [ + 122449 + ], + "children": [], + "area": 6539012.540928001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 122461, + "strid": "2dc265f3-a9b3-4bea-a063-4c16c778ecb3", + "image_id": 205267, + "image_name": "14562.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2491.832, + 3632.983, + 712.605, + 558.3919999999998 + ], + "priority": 24, + "parents": [ + 122469 + ], + "children": [], + "area": 9052783.294856, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements\n\nWe thank our colleagues from MSF\nLesvos Project, especially Ms Giovanna\nBonvini, Mental Health Activity Manager,\nand the translators including Mr Anmed\nAl-Humadi and Ms Evi Papakonstantinou\nwho assisted with the interviews. We\nthank the study participants for sharing\ntheir experiences and stories with us.\nThis research was conducted through\nthe Structured Operational Research\nand Training Initiative (SORT-IT)." + }, + { + "id": 21245, + "strid": "8c050e77-a6b8-4d0f-b041-97aa00c0e8f8", + "image_id": 201345, + "image_name": "116969.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 18.39, + 12.65, + 65.0, + 32.5 + ], + "priority": -1, + "parents": [], + "children": [ + 21253, + 21255, + 21259, + 21262, + 21246, + 21247, + 21248, + 21254, + 21256, + 21249, + 21250 + ], + "area": 232.63350000000003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 21246, + "strid": "067567e1-2b5a-42ed-9bab-9e765f43aa2d", + "image_id": 201345, + "image_name": "116969.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 107.034, + 66.255, + 538.802, + 47.33500000000001 + ], + "priority": 1, + "parents": [ + 21245 + ], + "children": [], + "area": 7091.53767, + "iscrowd": 0, + "segmentation": [], + "text": "Anovel méthod to confirm tracheal intubation based on\nairway préssures: validation in patients with lung disease." + }, + { + "id": 21247, + "strid": "4617af4d-dd62-477d-ba4a-e651dc7decae", + "image_id": 201345, + "image_name": "116969.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 19.944, + 142.699, + 711.342, + 52.510999999999996 + ], + "priority": 2, + "parents": [ + 21245 + ], + "children": [], + "area": 2845.988856, + "iscrowd": 0, + "segmentation": [], + "text": "Arjarine Fontan othe G. Monsieurs?, Frank Luijmes', Willem Dieperink', Jan G. Zijlstra’, Alain F. Kalmar’\n»'Departmentiof Critigal Care, University of Groningen, University Medical Center Groningen, The Netherlands\n—@ © © @Department of Emergency Medicine, Antwerp University Hospital, Belgium" + }, + { + "id": 21248, + "strid": "e6c9287b-f98b-4c65-8617-9bfd356a1b14", + "image_id": 201345, + "image_name": "116969.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 23.728, + 231.673, + 83.86099999999999, + 15.24799999999999 + ], + "priority": 3, + "parents": [ + 21245 + ], + "children": [ + 21258 + ], + "area": 5497.136944000001, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 21258, + "strid": "31b4c3d5-9246-48e4-8628-ab3b3915bcf8", + "image_id": 201345, + "image_name": "116969.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 23.665, + 255.572, + 333.526, + 213.15300000000002 + ], + "priority": 4, + "parents": [ + 21248 + ], + "children": [], + "area": 6048.11138, + "iscrowd": 0, + "segmentation": [], + "text": "Emengency Ogovachssl ivubslion resus in gugvental\noesophageal intubation in up to 17% of patients often with\ndisastrous consequences. We have previously published a highly\nspecific and sensitive novel method to Wetect endotracheal\ninubation based on differences in ventilation pressure waveforms\nin the oesophagus and in the trachea’ in patients with healthy\nlungs[t]. A detection algorithm, based on differences. in\ncompliancelelasticty between the lung and the oesophagus,\ngenerated a \"D-value\" indicating tracheal intubation if D>0.5 and\noesophageal intubation if D<0.5. The aim of the current study was\nto validate the algorithm in patients with lung disease." + }, + { + "id": 21256, + "strid": "95d6fdcf-213b-4c43-8c77-c83982fb785b", + "image_id": 201345, + "image_name": "116969.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 23.197, + 476.393, + 59.727999999999994, + 15.454000000000008 + ], + "priority": 5, + "parents": [ + 21245 + ], + "children": [ + 21257, + 21261 + ], + "area": 11050.888421, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 21261, + "strid": "a17a26b3-1a2f-46e1-aa5a-ca900f65d4b8", + "image_id": 201345, + "image_name": "116969.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 22.865, + 500.318, + 333.926, + 213.15300000000002 + ], + "priority": 6, + "parents": [ + 21256 + ], + "children": [], + "area": 11439.771069999999, + "iscrowd": 0, + "segmentation": [], + "text": "After obtaining institutional approval, twenty (iWiibated and\nventilated Intensive Care Unit patients were (included. Inclusion\ncfteria were controlled mechanical ventilation and at least mild to\nmoderate lung injury according to a MuiTay lung injury score >0.1\nA connecting piece was placed between the endotracheal tube\nand the ventilation bag. This piece comprised a thin air filed\ncatheter inserted through the tube lumen at 1 cm from the distal\nend, and a second catheter located at the proximal end of the\ntube, We performed three consecutive manual bag ventiltions\nwhile recording the pressure curves through both catheters. For\neach ventilation, a D-value was calculated." + }, + { + "id": 21257, + "strid": "1a364bb6-6c83-4f4d-aee8-b617f2f87b4c", + "image_id": 201345, + "image_name": "116969.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 41.296, + 725.323, + 293.064, + 126.61900000000003 + ], + "priority": 7, + "parents": [ + 21256 + ], + "children": [], + "area": 29952.938608, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 21253, + "strid": "7b3d8719-3b38-4d41-9642-4d4bf5f75daf", + "image_id": 201345, + "image_name": "116969.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 390.093, + 231.381, + 52.341999999999985, + 16.441000000000003 + ], + "priority": 8, + "parents": [ + 21245 + ], + "children": [ + 21263, + 21260 + ], + "area": 90260.108433, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 21263, + "strid": "38ed1a68-1647-4dbd-8b4c-ef8531e7fd1e", + "image_id": 201345, + "image_name": "116969.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 390.383, + 255.067, + 332.25499999999994, + 192.062 + ], + "priority": 9, + "parents": [ + 21253 + ], + "children": [], + "area": 99573.820661, + "iscrowd": 0, + "segmentation": [], + "text": "Mean age (SD) of the patients was 60 (16) years, 60% was male.\nThe mean (SD) Murray score was 1.4 (0.6). Pathologies included\npulmonary oedema, pneumonia, atelectasis and traumatic-lung\ninjury. All 60 D-values are represented in Fig. 1. The median (IQR,\nrange) Dvalue was 38 (16-74, 0.8-1272). Our algorithm therefore\nconfirmed a high sensitivity tot detect correct’ endotracheal\nintabation also in patients with lung disease. Under the hypothesis\nthat oesophageal compliance does not increase significantly in\npatients with lung disease, the specificity of our algorithm will nt\nbe affected." + }, + { + "id": 21260, + "strid": "cfba01fd-2978-4dbf-8283-50e5475620aa", + "image_id": 201345, + "image_name": "116969.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 388.118, + 490.443, + 332.723, + 146.529 + ], + "priority": 10, + "parents": [ + 21253 + ], + "children": [ + 21251 + ], + "area": 190349.75627399998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 21251, + "strid": "93ca2eaa-3665-49dc-9fa8-52bb069bb143", + "image_id": 201345, + "image_name": "116969.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 390.121, + 473.892, + 55.891999999999996, + 15.103999999999985 + ], + "priority": 11, + "parents": [ + 21260 + ], + "children": [], + "area": 184875.220932, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1" + }, + { + "id": 21259, + "strid": 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"children": [], + "area": 4114.2662820000005, + "iscrowd": 0, + "segmentation": [], + "text": "Cancer patient survival can be accurately parameterized, improving trial precision\nand revealing time-dependent therapeutic effects" + }, + { + "id": 148292, + "strid": "78ea33b8-1384-450c-8f93-53af53c5592a", + "image_id": 206258, + "image_name": "19222.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 627.741, + 266.237, + 3551.157, + 340.38400000000007 + ], + "priority": 2, + "parents": [ + 148316 + ], + "children": [], + "area": 167127.88061700002, + "iscrowd": 0, + "segmentation": [], + "text": "Deborah Plana’, Geoffrey Fell®, Brian M. Alexander®*+, Adam C. Palmer®, Peter K. Sorger™\n\n‘Laboratory of Systems Pharmacology and the Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA. *Harvard-MIT Division of\nHealth Sciences and Technology, Harvard Medical School and MIT, Cambridge, Massachusetts, USA.*Dana-Farber Cancer Institute, Boston, Massachusetts,\nUSA. 4Foundation Medicine Inc., Cambridge, Massachusetts, USA. Department of Pharmacology, Computational Medicine Program, Lineberger\nComprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. *These authors contributed equally" + }, + { + "id": 148293, + "strid": "3cb82d15-624d-4e50-b344-4f0910e25e16", + "image_id": 206258, + "image_name": "19222.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 547.665, + 638.376, + 496.2449999999999, + 99.46600000000001 + ], + "priority": 3, + "parents": [ + 148316 + ], + "children": [ + 148298 + ], + "area": 349616.19203999994, + "iscrowd": 0, + "segmentation": [], + "text": "Key Points" + }, + { + "id": 148298, + "strid": "dc29105d-ab3a-4a8a-99cd-553dc3a5cb2c", + "image_id": 206258, + "image_name": "19222.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 13.835, + 784.274, + 1555.094, + 745.2000000000002 + ], + "priority": 4, + "parents": [ + 148293 + ], + "children": [], + "area": 10850.43079, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 148295, + "strid": "bcc06d09-c634-45bb-b51f-03a6abe9a452", + "image_id": 206258, + "image_name": "19222.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 597.996, + 1588.869, + 393.678, + 82.27600000000007 + ], + "priority": 5, + "parents": [ + 148316 + ], + "children": [ + 148305, + 148309, + 148304, + 148303, + 148311, + 148310 + ], + "area": 950137.3065239999, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 148303, + "strid": "825c0a7b-1046-4930-8f78-1206cc366572", + "image_id": 206258, + "image_name": "19222.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 18.988, + 1724.593, + 1201.33, + 56.509000000000015 + ], + "priority": 6, + "parents": [ + 148295 + ], + "children": [], + "area": 32746.571884, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 148309, + "strid": "5881720c-f0d0-486c-990c-f77c093c9b7e", + "image_id": 206258, + "image_name": "19222.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 87.123, + 1797.331, + 1403.789, + 442.23800000000006 + ], + "priority": 7, + "parents": [ + 148295 + ], + "children": [], + "area": 156588.868713, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 148304, + "strid": "8b12811f-de85-44a8-a02b-93fb9f1b2839", + "image_id": 206258, + "image_name": "19222.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 22.428, + 2285.448, + 1505.037, + 159.91699999999992 + ], + "priority": 8, + "parents": [ + 148295 + ], + "children": [], + "area": 51258.027744, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 148310, + "strid": "3c37a457-5595-460d-9c84-0827e71a1113", + "image_id": 206258, + "image_name": "19222.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 177.82, + 2467.977, + 1210.711, + 464.35199999999986 + ], + "priority": 9, + "parents": [ + 148295 + ], + "children": [], + "area": 438855.67013999994, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 148305, + "strid": "35aa1fde-61fc-47ed-95ab-5a23566b0e87", + "image_id": 206258, + "image_name": "19222.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 22.589, + 2947.031, + 1386.812, + 50.91300000000001 + ], + "priority": 10, + "parents": [ + 148295 + ], + "children": [], + "area": 66570.483259, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 148311, + "strid": "66fb7392-461b-4765-9de5-9bcd0a947711", + "image_id": 206258, + "image_name": "19222.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 388.256, + 3027.957, + 765.8830000000002, + 540.6129999999998 + ], + "priority": 11, + "parents": [ + 148295 + ], + "children": [], + "area": 1175622.472992, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 148294, + "strid": "9a015f29-f786-4664-b55f-22a79d735b4d", + "image_id": 206258, + "image_name": "19222.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2232.958, + 638.647, + 345.75300000000016, + 82.52800000000002 + ], + "priority": 12, + "parents": [ + 148316 + ], + "children": [ + 148313, + 148302, + 148315, + 148312, + 148314, + 148307, + 148301, + 148306, + 148299 + ], + "area": 1426071.9278260001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 148299, + "strid": "a2a38b19-bf54-4537-a439-bb42ffe23d5c", + "image_id": 206258, + "image_name": "19222.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1625.774, + 779.145, + 1543.616, + 111.61500000000001 + ], + "priority": 13, + "parents": [ + 148294 + ], + "children": [], + "area": 1266713.6832299998, + "iscrowd": 0, + "segmentation": [], + "text": "Two-parameter Weibull distributions accurately describe overall survival\n(OS; R2 =0.981) and visualize survival differences across cancer types." + }, + { + "id": 148312, + "strid": "c294cd47-e730-4038-a2aa-44763b625e38", + "image_id": 206258, + "image_name": "19222.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1633.685, + 923.61, + 1538.6619999999998, + 1094.569 + ], + "priority": 14, + "parents": [ + 148294 + ], + "children": [], + "area": 1508887.8028499999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 148301, + "strid": "9871f849-4d81-4b57-8984-a12a66e18ad6", + "image_id": 206258, + "image_name": "19222.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1623.883, + 2072.197, + 1508.4109999999998, + 233.49400000000014 + ], + "priority": 15, + "parents": [ + 148294 + ], + "children": [], + "area": 3365005.4809510005, + "iscrowd": 0, + "segmentation": [], + "text": "Trial success is assessed by using a statistical test that assumes that\nsurvival curves for treatment arms have the same shape (proportional\nhazards). 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"bbox": [ + 519.13, + 377.276, + 2349.432, + 90.09199999999998 + ], + "priority": 1, + "parents": [ + 73100 + ], + "children": [], + "area": 195855.28988, + "iscrowd": 0, + "segmentation": [], + "text": "APACE: Accelerated Permutation Inference for the ACE Model" + }, + { + "id": 73085, + "strid": "073a7853-7171-4935-9444-f39360e6e634", + "image_id": 203348, + "image_name": "120080.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 733.887, + 482.663, + 1904.872, + 397.24299999999994 + ], + "priority": 2, + "parents": [ + 73100 + ], + "children": [], + "area": 354220.101081, + "iscrowd": 0, + "segmentation": [], + "text": "Xu Chen!, Stev@ Smith’, Essi Viding®, T .E. Nichols!?\n| Departm@nt of Statistics, University of wy , Coventry, UK,\nSS EMRIB Centre, Oxford Univers ord, UK,\n3 Depesument of Psychology, University eS ege London, London, UK\nemail, @@. chen@warwick.ac.uk, toe nichols@warwick.ac. yk" + }, + { + "id": 73086, + "strid": "a9851ad5-8215-4283-b16f-ac50836bbc43", + "image_id": 203348, + "image_name": "120080.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 158.424, + 973.875, + 395.842, + 63.909000000000106 + ], + "priority": 3, + "parents": [ + 73100 + ], + "children": [ + 73087 + ], + "area": 154285.173, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 73087, + "strid": "95e9276c-8a79-47b1-8299-866540ba202e", + "image_id": 203348, + "image_name": "120080.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 148.385, + 1056.02, + 1000.231, + 2351.842 + ], + "priority": 4, + "parents": [ + 73086 + ], + "children": [], + "area": 156697.52769999998, + "iscrowd": 0, + "segmentation": [], + "text": "Heritability studies\\of imaging phe-\nnotypes are becoming more common-\nplace. Heritability, the proportion of\nphenotypiccvariance attributable to ge-\nnetic sources, is typically estimated\nwith variance components model (e.g:\nin@SOLAR) or structural equation\nmodels (e.g. in OpenMx), but/these\napproaches are computationally, expen-\nsive and cannot exploit thexsensitivity\nof the spatial statistics,;“ike cluster-\nwise tests. Thus, \\we developed a\nnon-iterative estimation method for the\nACE model; -this method is accurate\n[1] and is sofast that it allows the use\nof perniutation, which provides sensi-\ntive family-wise error (FWE) corrected\nvoxel- and cluster-wise inferences [| lk.\n\nIn this work we demonstratesour tool\nand its ability to consider. ‘arbitrary\nstatistics. In particular, we fit the\nACE model for twin~data (and the\nHCP extended-twin design) at each\nvoxel and compute summary and ag-\ngregate measures of heritability (de-\ntails in [2|applications in [3][4]). We\ncall our Matlab-based tool “‘Acceler-\nated\\Permutation Inference for the ACE\nModel (APACE)”’, and are distributing\nit freely." + }, + { + "id": 73091, + "strid": "997e1d41-6f12-4076-923b-df5040d7d05c", + "image_id": 203348, + "image_name": "120080.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 163.045, + 3449.955, + 271.70000000000005, + 65.0 + ], + "priority": 5, + "parents": [ + 73100 + ], + "children": [ + 73088, + 73092 + ], + "area": 562497.912975, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 73088, + "strid": "6da2113f-a71b-48c3-8fcb-07a6b2008a5a", + "image_id": 203348, + "image_name": "120080.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 155.361, + 3529.942, + 992.657, + 988.9669999999996 + ], + "priority": 6, + "parents": [ + 73091 + ], + "children": [], + "area": 548415.3190619999, + "iscrowd": 0, + "segmentation": [], + "text": "APACE is partitioned into’4 main parts:\nthe preparation for the analysis, permu-\ntation analysis fer.computing p-values,\nbootstrappingc analysis for generating\nconfidence ‘intervals (CI’s) and aggre-\ngate heritability analysis. It offers 4\noptional inference approaches: voxel-\nwise inference, cluster-wise inference,\nsummary measure inference, and» the\naggregate inference. The default is to\nimplement all inferences, ‘but the users\ncan easily select only the-desired infer-\nences. The outputs ofthis tool include" + }, + { + "id": 73092, + "strid": "5e2f51fc-745b-455a-831f-6ff40a773a25", + "image_id": 203348, + "image_name": "120080.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1176.342, + 965.74, + 998.2890000000002, + 2431.316 + ], + "priority": 7, + "parents": [ + 73091 + ], + "children": [], + "area": 1136040.5230800002, + "iscrowd": 0, + "segmentation": [], + "text": "image-wise heritability estimates and\np-values from@yoxel-wise and cluster-\nwise inferences, and the estimates,\np-values.-and CI’s of the summary\nand caggregate heritability measures;\nAPACE is script-based and is designed\nto be easily parallelized over a comput-\ning cluster.\n\nWe illustrate the heritability inference\nfor voxels, clusters~and whole-image\nsummaries carriedout with APACE us-\ning an f{MRICdataset of 111 subjects\nincluding, 16~monozygotic twin pairs,\n25 dizygotic twin pairs and 29 unre-\nlated-individuals. All participants were\nmales and aged 10-12 from the Twins\nEarly Development Study (TEDS) [5],\nand performed an IAPS emotional pic-\ntures matching task during the exper-\niment, where 50 subjects out of 111\nwere with behaviouralproblems by the\nSDQ assessment,-Our analysis focused\non amygdala, which is a brain area typ-\nically implicated in emotional process-\ning tasks\\.We computed the estimates,\np-values (with 1000 permutations) and.\nCl’s(with 1000 bootstrap replicates) of\nthe summary measures for the -amyg-\ndala region, and outputted the ymage-\nwise results of estimates and p-values\nfor voxels and clusters." + }, + { + "id": 73090, + "strid": "63bd9f95-1023-4145-abbb-e2d9b2272a13", + "image_id": 203348, + "image_name": "120080.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1182.21, + 3446.106, + 228.15599999999995, + 66.31700000000001 + ], + "priority": 8, + "parents": [ + 73100 + ], + "children": [ + 73096, + 73093, + 73089, + 73094 + ], + "area": 4074020.9742600005, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 73089, + "strid": "2e6bbeb5-150e-4347-a58b-35c410ba3d72", + "image_id": 203348, + "image_name": "120080.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1177.539, + 3526.251, + 990.8120000000001, + 976.0519999999997 + ], + "priority": 9, + "parents": [ + 73090 + ], + "children": [], + "area": 4152298.076289, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1 shows,that the average her-\nitability in amygdala obtained strong\nsignificance” Although the best FWE-\ncorrectéd: p-value for voxels was not\nsignificant, cluster statistics were found\nsignificant, demonstrating the impof-\ntance of these spatial statistics,© Fig-\nure 1 shows the brain area considered,\nthe 555-voxel amygdala mask in green,\nand the significant clusters (PpwE <\n0.05), 2 clusters comprised of 167 vox-\nels, in red. The cluster-forming thresh-\nold is wu = 2.706, or p = 0.05 based on" + }, + { + "id": 73093, + "strid": "53b62b52-7024-47bc-9726-f3c7099b517c", + "image_id": 203348, + "image_name": "120080.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2200.13, + 969.131, + 986.7960000000003, + 141.6450000000001 + ], + "priority": 10, + "parents": [ + 73090 + ], + "children": [], + "area": 2132214.18703, + "iscrowd": 0, + "segmentation": [], + "text": "the parametric likelihood ratio null dis-\ntribution." + }, + { + "id": 73094, + "strid": "72cb8515-608e-4ab3-9fa4-6bbfe70e8cc6", + "image_id": 203348, + "image_name": "120080.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2241.034, + 1158.027, + 904.558, + 669.0709999999999 + ], + "priority": 11, + "parents": [ + 73090 + ], + "children": [ + 73095 + ], + "area": 2595177.879918, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 73095, + "strid": "297cc073-d6a6-4c58-8649-88f33356a4bd", + "image_id": 203348, + "image_name": "120080.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2201.095, + 1861.138, + 987.6700000000001, + 209.97699999999986 + ], + "priority": 12, + "parents": [ + 73094 + ], + "children": [], + "area": 4096541.5461099995, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1: Estimates, p-values and 95% CI’s of the\nsummary easures and maximum statistics fro\n\n° . .\n_¢..voxel- and cluster-wise inferences. ..@" + }, + { + "id": 73096, + "strid": "c90954cb-28db-4458-acac-41d9a1e5948f", + "image_id": 203348, + "image_name": "120080.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2204.239, + 2116.952, + 975.788, + 942.8540000000003 + ], + "priority": 13, + "parents": [ + 73090 + ], + "children": [ + 73097 + ], + "area": 4666268.159528, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 73097, + "strid": "6983b2d7-da98-49e0-ba8c-2f09ab74089d", + "image_id": 203348, + "image_name": "120080.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2201.876, + 3090.808, + 977.2780000000002, + 215.57600000000002 + ], + "priority": 14, + "parents": [ + 73096 + ], + "children": [], + "area": 6805575.955808001, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1: FWE-corrected p-valueimage (after\n-log10 transformation) of si\nred) for the amygdalaa" + }, + { + "id": 73099, + "strid": "00c3247b-9247-4fa0-a747-606183e8986b", + "image_id": 203348, + "image_name": "120080.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2201.666, + 3362.238, + 373.24400000000014, + 63.346000000000004 + ], + "priority": 15, + "parents": [ + 73100 + ], + "children": [ + 73098 + ], + "area": 7402525.088508001, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 73098, + "strid": "4f67dae0-5b25-4145-baad-67b73eb181d0", + "image_id": 203348, + "image_name": "120080.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2194.128, + 3443.342, + 1000.067, + 749.5790000000002 + ], + "priority": 16, + "parents": [ + 73099 + ], + "children": [], + "area": 7555133.095776001, + "iscrowd": 0, + "segmentation": [], + "text": "Our newly developed Matlab-based\ntool APACE provides different anal-\nysis approaches specialized for heri-\ntability inference, in which the use\nof6 months. However, the direct and indirect\nepidemiological impact of vaccination for all age and risk groups from the\nsocietal standpoint are less known. Direct benefits of vaccine includes the\nnumber of averted cases and Influenza associated outcomes among\nvaccinated individuals [1]. Indirect impacts of vaccination arises because\neffectively vaccinated individuals reduce pathways of transmission to\nsecondary and subsequent cases. This study applies a dynamic agent-\nbased model to estimate the direct and indirect epidemiological impact, and\n\nconduct cost-benefit analysis of vaccine-based interventions." + }, + { + "id": 188458, + "strid": "e837b132-7b1b-43ec-9846-3fbca3b99426", + "image_id": 207853, + "image_name": "8950.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 497.888, + 1801.896, + 416.055, + 68.00900000000001 + ], + "priority": 7, + "parents": [ + 188480 + ], + "children": [ + 188466, + 188479, + 188465, + 188473, + 188477, + 188478, + 188474, + 188475 + ], + "area": 897142.395648, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 188465, + "strid": "290927ed-7b5c-4216-b31c-1baeca2a8426", + "image_id": 207853, + "image_name": "8950.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 118.301, + 1908.727, + 1159.768, + 855.4089999999999 + ], + "priority": 8, + "parents": [ + 188458 + ], + "children": [], + "area": 225804.31282700002, + "iscrowd": 0, + "segmentation": [], + "text": "Chicago was selected to study the impact of vaccination intervention on\ndifferent severity of pandemic influenza. We use a collocation based\nsynthetic social contact network, generated for the city of Chicago,\nusing the methodology explained in [2-4]. The transmission dynamics\nof the influenza-like-illness in the population is simulated using the\nsusceptible-exposed-infectious-recovered (SEIR) epidemiological\nmodel. We use an agent-based model to compare the costs and\nbenefits of vaccine-based interventions under different transmission\nscenarios during an influenza pandemic.\n\nFor the base case, three different forms of pandemic influenza were\n\ndesigned:" + }, + { + "id": 188473, + "strid": "f4822ceb-7a05-4880-87bc-fb4ed9e0710a", + "image_id": 207853, + "image_name": "8950.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 121.65, + 2781.314, + 953.8260000000001, + 215.337 + ], + "priority": 9, + "parents": [ + 188458 + ], + "children": [], + "area": 338346.8481, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 188466, + "strid": "afc41ae6-711a-47f4-890f-8059d5e7d48e", + "image_id": 207853, + "image_name": "8950.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 120.993, + 3029.809, + 1110.153, + 454.9580000000001 + ], + "priority": 10, + "parents": [ + 188458 + ], + "children": [], + "area": 366585.680337, + "iscrowd": 0, + "segmentation": [], + "text": "Influenza associated outcomes include: death, hospitalization,\noutpatient visit, and illness (without medical care).\n\nVaccine intervention: 40% of population is vaccinated, and vaccine\nefficacy is 40%. Figure 1 illustrated the incidence of influenza before\nand after vaccination for different forms of pandemic influenza based\n\non the dynamic model." + }, + { + "id": 188477, + "strid": "62882acc-2887-406c-9be9-3025b45c884b", + "image_id": 207853, + "image_name": "8950.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2314.872, + 489.034, + 1103.3979999999997, + 1012.2480000000002 + ], + "priority": 11, + "parents": [ + 188458 + ], + "children": [ + 188470 + ], + "area": 1132051.113648, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 188470, + "strid": "52510fc6-dbd6-43d8-a40b-5bf044a4e2c5", + "image_id": 207853, + "image_name": "8950.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1424.393, + 610.636, + 852.5839999999998, + 804.47 + ], + "priority": 12, + "parents": [ + 188477 + ], + "children": [], + "area": 869785.6439479999, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1: Influenza incidence (average number of\nnew cases per day) during the pandemic for no\nvaccine intervention and vaccine intervention\nscenarios. The number of cases is the average of new\ncases over 25 simulations. For the base case scenario\nof no vaccine intervention, the epidemic curves show\nthe incidence during the catastrophic, strong and\nmoderate influenza pandemic scenarios. Higher attack\nrates cause the earlier, more severe, and shorter\npandemic duration, compared to the less severe but\nlonger pandemics. The vaccination intervention is\napplied 15 days after the start of pandemic and\nimplemented for 60 days. The vaccine intervention\nscenarios are simulated at 40% efficacy and 40%\ncompliance for all age and risk groups in the dynamic\nagent-based model." + }, + { + "id": 188478, + "strid": "b7e1c6c7-574e-4018-badf-e3534bf19cb8", + "image_id": 207853, + "image_name": "8950.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1419.341, + 1540.34, + 1856.9590000000003, + 806.164 + ], + "priority": 13, + "parents": [ + 188458 + ], + "children": [ + 188471 + ], + "area": 2186267.7159399996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 188471, + "strid": "9fff5e13-3a07-460e-b4af-eb87ad204bcb", + "image_id": 207853, + "image_name": "8950.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1441.891, + 2371.902, + 2008.498, + 103.81899999999996 + ], + "priority": 14, + "parents": [ + 188478 + ], + "children": [], + "area": 3420024.1466820003, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2: Reduction reproduction number and associated return on investment for static and dynamic models. Static model\nincludes direct impact of vaccination; (agent-based) dynamic model includes both direct and indirect impact of vaccination" + }, + { + "id": 188474, + "strid": "3ed3a26d-c663-45bb-86db-923a976bdf02", + "image_id": 207853, + "image_name": "8950.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1441.88, + 2475.936, + 985.9549999999999, + 96.66199999999981 + ], + "priority": 15, + "parents": [ + 188458 + ], + "children": [], + "area": 3570002.5996800005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 188479, + "strid": "7d741294-6384-43d4-9076-6cc290860156", + "image_id": 207853, + "image_name": "8950.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1427.178, + 2554.028, + 1956.849, + 738.2379999999998 + ], + "priority": 16, + "parents": [ + 188458 + ], + "children": [ + 188472 + ], + "area": 3645052.572984, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 188472, + "strid": "50027bfb-c74c-4357-afec-88c55e9dd430", + "image_id": 207853, + "image_name": "8950.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1440.993, + 3318.189, + 1831.261, + 45.45600000000013 + ], + "priority": 17, + "parents": [ + 188479 + ], + "children": [], + "area": 4781487.121676999, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3: Prioritization of influenza vaccine intervention based on return on investment and risk of death criteria." + }, + { + "id": 188475, + "strid": "39db5811-3b1b-40ee-ab1b-056ffdb64422", + "image_id": 207853, + "image_name": "8950.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1439.778, + 3362.591, + 2022.2770000000003, + 157.33100000000013 + ], + "priority": 18, + "parents": [ + 188458 + ], + "children": [], + "area": 4841384.544798, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 188459, + "strid": "d116d835-3e7a-4f97-b001-b53428b36546", + "image_id": 207853, + "image_name": "8950.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3956.298, + 483.168, + 386.3729999999996, + 76.98400000000004 + ], + "priority": 19, + "parents": [ + 188480 + ], + "children": [ + 188467 + ], + "area": 1911556.592064, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 188467, + "strid": "80e1fa25-318b-4aad-9340-5b26e30f0896", + "image_id": 207853, + "image_name": "8950.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3651.64, + 612.359, + 965.0530000000003, + 774.8349999999999 + ], + "priority": 20, + "parents": [ + 188459 + ], + "children": [], + "area": 2236114.61876, + "iscrowd": 0, + "segmentation": [], + "text": "Figures 2 illustrates the direct and indirect impacts of\nvaccination. Vaccination of 40% of the population results in\n19.84% (range: 17.41%-23.84%) reduction in the attack\nrate of influenza in the dynamic model, compared to 6.77%\n(range: 4.7%, 9.4%) reduction in the attack rate in the static\nmodel [1]. In summary, vaccination results in 28.7 (range:\n21.6, 40.0) higher return on investment in the dynamic\nmodel in comparison to the static model. Figure 3 illustrates\nvaccination prioritization. Based on the selected criteria,\n\nhigh risk population can be prioritized for vaccination." + }, + { + "id": 188460, + "strid": "d0eaa0d1-f32f-41a2-b78f-dd20e262cdc8", + "image_id": 207853, + "image_name": "8950.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3887.311, + 1435.576, + 515.694, + 69.31899999999996 + ], + "priority": 21, + "parents": [ + 188480 + ], + "children": [ + 188468 + ], + "area": 5580530.376136, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 188468, + "strid": "cc6a091e-f44b-4b81-aeba-75a9114d54a6", + "image_id": 207853, + "image_name": "8950.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3660.418, + 1533.586, + 979.4060000000004, + 1256.41 + ], + "priority": 22, + "parents": [ + 188460 + ], + "children": [], + "area": 5613565.798948, + "iscrowd": 0, + "segmentation": [], + "text": "Based on comparison of vaccine-based intervention\nscenarios and health outcomes from the static model [1]\nand the dynamic agent-based model, more cases of\ninfluenza are averted, and vaccination is more cost effective\nfor all age and risk groups. Relatively better estimates of\nepidemiological impact and cost-benefit outcomes can be\nestimated using dynamic models, such as the agent-based\nmodel used in this study, in comparison to static models.\nPublic health implications: The dynamic model provides\nimproved estimates of the epidemiological and economic\nbenefits of vaccine interventions in comparison to a static\nmodel, by accounting for both the direct and indirect effects.\nThese estimates assist in prioritization of vaccine\ninterventions among subpopulations of different risk and\nage groups, especially during influenza pandemics with\n\nlimited availability of vaccines." + }, + { + "id": 188461, + "strid": "1eb42354-d2fb-4bc6-bcc5-4d7c46241d40", + "image_id": 207853, + "image_name": "8950.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3876.22, + 2847.6, + 566.6969999999997, + 70.17300000000023 + ], + "priority": 23, + "parents": [ + 188480 + ], + "children": [ + 188476 + ], + "area": 11037924.071999999, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 188476, + "strid": "ca1adc05-8255-4f68-b0e0-a28286b7d6ff", + "image_id": 207853, + "image_name": "8950.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3663.166, + 2935.626, + 937.8760000000002, + 244.20200000000023 + ], + "priority": 24, + "parents": [ + 188461 + ], + "children": [], + "area": 10753685.351916002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 188462, + "strid": "51173240-2300-4344-857b-e165d655d7da", + "image_id": 207853, + "image_name": "8950.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3805.623, + 3209.097, + 710.3650000000002, + 53.8159999999998 + ], + "priority": 25, + "parents": [ + 188480 + ], + "children": [ + 188469 + ], + "area": 12212613.352431001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 188469, + "strid": "f2237ca5-3908-4233-9ca0-f1cec999dc60", + "image_id": 207853, + "image_name": "8950.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3662.181, + 3291.143, + 990.6349999999998, + 162.933 + ], + "priority": 26, + "parents": [ + 188462 + ], + "children": [], + "area": 12052761.362883, + "iscrowd": 0, + "segmentation": [], + "text": "This study is supported by the Biomedical and Veterinary Sciences\ngraduate program at Virginia Tech, NIH grant RO1GM109718,\nNSF-ICES grant 1216000, DTRA grant HDTRA1-11-1-0016, and\nDTRA grant HDTRA1-11-D-0016-0001." + }, + { + "id": 3821, + "strid": "f8023b15-a842-421a-8f21-000e1afae742", + "image_id": 200657, + "image_name": "10488.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 116.17, + 19.97, + 363.03999999999996, + 136.14000000000001 + ], + "priority": -1, + "parents": [], + "children": [ + 3791, + 3796, + 3790, + 3793, + 3795, + 3794, + 3789, + 3792 + ], + "area": 2319.9148999999998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 3789, + "strid": "3026d56e-f417-489e-b0fd-867beb983fd9", + "image_id": 200657, + "image_name": "10488.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 1302.437, + 49.712, + 2128.186, + 235.94600000000003 + ], + "priority": 1, + "parents": [ + 3821 + ], + "children": [], + "area": 64746.748144, + "iscrowd": 0, + "segmentation": [], + "text": "Abundance-based reconstitution of microbial\npan-genomes from shotgun metagenomic data" + }, + { + "id": 3790, + "strid": "b9316c6c-eeeb-46c6-8e17-de1b4d4ec3b5", + "image_id": 200657, + "image_name": "10488.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 833.936, + 332.524, + 3066.414, + 134.27800000000002 + ], + "priority": 2, + "parents": [ + 3821 + ], + "children": [], + "area": 277303.73446400004, + "iscrowd": 0, + "segmentation": [], + "text": "Florian PLAZA ONATE“@, Frédéric MAGOULES<, Alessandra CERVINO2, S. Dusko EHRLICH ®4 & Matthieu PICHAUD 4\n\n4 Enterome, 94-96 Avenue Ledru Rollin, 75011 Paris, France > MGP MetaGénoPolis, INRA, Université Paris-Saclay, 78350 Jouy en Josas, France ©CentraleSupélec, Université Paris-Saclay, 92290 Chatenay-Malabry, France ¢King’s College London, Centre for Host-Microbiome Interactions, London, UK" + }, + { + "id": 3791, + "strid": "147ce389-a5a3-4941-8734-47fc937f24dc", + "image_id": 200657, + "image_name": "10488.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 473.532, + 574.782, + 395.95700000000005, + 70.654 + ], + "priority": 3, + "parents": [ + 3821 + ], + "children": [ + 3797 + ], + "area": 272177.670024, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 3797, + "strid": "303cfdda-2535-4861-bb44-0423d2a9f6f3", + "image_id": 200657, + "image_name": "10488.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 94.989, + 685.119, + 1157.211, + 947.8550000000001 + ], + "priority": 4, + "parents": [ + 3791 + ], + "children": [], + "area": 65078.768691000005, + "iscrowd": 0, + "segmentation": [], + "text": "Metagenomic shotgun sequencing is a culture-free technology that\nallows strain-level characterization of complex microbial communities.\n\nRecent analysis pipelines can capture intra-species gene content\nvariability and SNPs within and between metagenomic samples. [1,2,3]\n\nHowever, these tools rely on sparse reference genomes databases which\nlimit the scope of the analysis.\n\nNielsen et al. [4] showed that genomes of microbial organisms can be\nreconstituted by binning co-abundant genes obtained from de novo\nmetagenomics assembly. This method groups core genes and highly\nprevalent accessory genes but misses rare accessory genes or assigns them\nto small separated clusters. Moreover, Pearson correlation used to detect\nrelated genes is highly sensitive to outliers and may miss some relevant\nrelations.\n\nWe propose a new method that reconstitutes species pangenomes by\nbinning co-abundant genes across metagenomic samples. It distinguishes\ncore genes from accessory and shared genes even when rarely observed.\nThe method relies on a new robust score that is only limited by the number\nof reads mapped on a gene and its prevalence across samples." + }, + { + "id": 3792, + "strid": "19708693-1a74-4bb3-af41-f127d58871bf", + "image_id": 200657, + "image_name": "10488.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 526.32, + 1754.642, + 300.145, + 70.24700000000007 + ], + "priority": 5, + "parents": [ + 3821 + ], + "children": [ + 3813, + 3798 + ], + "area": 923503.1774400001, + "iscrowd": 0, + "segmentation": [], + "text": "Rationale" + }, + { + "id": 3813, + "strid": "a72c4b03-9952-44ff-8270-f04977b03148", + "image_id": 200657, + "image_name": "10488.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 97.65, + 1889.374, + 1154.376, + 772.0820000000001 + ], + "priority": 6, + "parents": [ + 3792 + ], + "children": [ + 3801 + ], + "area": 184497.37110000002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 3801, + "strid": "5f17d37b-6614-473c-b477-c7f7970f6888", + "image_id": 200657, + "image_name": "10488.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 113.935, + 2704.459, + 947.393, + 40.603000000000065 + ], + "priority": 7, + "parents": [ + 3813 + ], + "children": [], + "area": 308132.536165, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 1. Simple model illustrating the rationale behind the method" + }, + { + "id": 3798, + "strid": "8db5ce3c-ac21-41a7-9f33-763bdecf593b", + "image_id": 200657, + "image_name": "10488.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 107.906, + 2748.528, + 1104.707, + 357.4290000000001 + ], + "priority": 8, + "parents": [ + 3792 + ], + "children": [], + "area": 296582.662368, + "iscrowd": 0, + "segmentation": [], + "text": "5 samples carry different strains from the same species. Three core genes (red, blue,\norange) are present in all the strains. Two accessory genes (green, purple) are present\nonly in some strains. The abundance of the species in each sample ranges from 1 to 3\ncopies.\n\nAfter shotgun sequencing, a raw gene abundance matrix is built.\n\nA strict proportionality relationship is expected between two core genes, the\nproportionality coefficient being equal to the ratio of their length. In contrast, such\nrelationship between a core and an accessory gene should be observed only in the\nsubset of samples where the accessory gene is present." + }, + { + "id": 3793, + "strid": "5f779941-1957-4dc2-a28f-c09240a0d132", + "image_id": 200657, + "image_name": "10488.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2154.695, + 574.179, + 282.8789999999999, + 69.56000000000006 + ], + "priority": 9, + "parents": [ + 3821 + ], + "children": [ + 3815, + 3818, + 3811, + 3814, + 3817, + 3816 + ], + "area": 1237180.620405, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 3814, + "strid": "7414dbc6-e003-4b16-b4fa-2d2fc419aedd", + "image_id": 200657, + "image_name": "10488.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1428.067, + 679.054, + 751.2339999999999, + 503.352 + ], + "priority": 10, + "parents": [ + 3793 + ], + "children": [ + 3802 + ], + "area": 969734.6086179999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 3802, + "strid": "858334ea-f17e-4abd-a838-5ebc1f0f5c5b", + "image_id": 200657, + "image_name": "10488.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1416.578, + 1190.273, + 529.7640000000001, + 88.2940000000001 + ], + "priority": 11, + "parents": [ + 3814 + ], + "children": [], + "area": 1686114.545794, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 2. structuration of MSPs\n(Metagenomic Species Pan-genomes)" + }, + { + "id": 3815, + "strid": "b971eb3e-852e-4db6-a21f-7432465ed6b3", + "image_id": 200657, + "image_name": "10488.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2328.536, + 706.878, + 849.8800000000001, + 472.9989999999999 + ], + "priority": 12, + "parents": [ + 3793 + ], + "children": [ + 3803 + ], + "area": 1645990.870608, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 3803, + "strid": "1fbb7872-fdf6-4f29-ae45-4981f50e66f6", + "image_id": 200657, + "image_name": "10488.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2337.575, + 1191.795, + 835.748, + 86.77199999999993 + ], + "priority": 13, + "parents": [ + 3815 + ], + "children": [], + "area": 2785910.197125, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3.a. Illustration of a core gene in the MSP\ncorresponding to R. bromii" + }, + { + "id": 3816, + "strid": "2d60ae22-d74c-46b7-867c-1aa8a1cccd86", + "image_id": 200657, + "image_name": "10488.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1400.244, + 1316.465, + 852.4100000000001, + 478.058 + ], + "priority": 14, + "parents": [ + 3793 + ], + "children": [ + 3804 + ], + "area": 1843372.2174599997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 3804, + "strid": "e021b4a9-4ec5-414d-bb47-c78d62e8adbb", + "image_id": 200657, + "image_name": "10488.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1408.148, + 1805.576, + 832.3509999999999, + 88.02500000000009 + ], + "priority": 15, + "parents": [ + 3816 + ], + "children": [], + "area": 2542518.233248, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3.b. Illustration of an accessory gene in the MSP\ncorresponding to R. bromii" + }, + { + "id": 3817, + "strid": "a40b5a9b-d37f-43ed-b068-f3fe9a15fc97", + "image_id": 200657, + "image_name": "10488.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2323.477, + 1316.465, + 854.9389999999999, + 475.528 + ], + "priority": 16, + "parents": [ + 3793 + ], + "children": [ + 3805 + ], + "area": 3058776.1488049994, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 3805, + "strid": "1ee6cbca-183c-4548-88e5-8e4d3e574d02", + "image_id": 200657, + "image_name": "10488.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2338.88, + 1806.871, + 834.94, + 85.43599999999992 + ], + "priority": 17, + "parents": [ + 3817 + ], + "children": [], + "area": 4226054.44448, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 3.c. Illustration of a shared accessory gene in the\nMSP corresponding to R. bromii" + }, + { + "id": 3818, + "strid": "315fcd49-4c66-420f-8b34-6d3a4d4a8fb7", + "image_id": 200657, + "image_name": "10488.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1672.876, + 1928.127, + 1252.1049999999998, + 724.634 + ], + "priority": 18, + "parents": [ + 3793 + ], + "children": [ + 3806 + ], + "area": 3225517.383252, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 3806, + "strid": "1b247cc5-f68b-4f5b-a8e2-fd80d23dd405", + "image_id": 200657, + "image_name": "10488.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1695.435, + 2674.354, + 990.172, + 48.95600000000013 + ], + "priority": 19, + "parents": [ + 3818 + ], + "children": [], + "area": 4534193.373989999, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 4. Workflow for Metagenomics Species Pan-genomes generation" + }, + { + "id": 3811, + "strid": "b7664982-4d1a-40fc-bc83-6670b80b4779", + "image_id": 200657, + "image_name": "10488.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1449.829, + 2729.729, + 1691.6919999999998, + 380.69000000000005 + ], + "priority": 20, + "parents": [ + 3793 + ], + "children": [], + "area": 3957640.2663409994, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 3794, + "strid": "ea5666ec-bed3-47ab-9b6c-0734cd371382", + "image_id": 200657, + "image_name": "10488.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3874.53, + 575.049, + 223.32100000000037, + 64.38099999999997 + ], + "priority": 21, + "parents": [ + 3821 + ], + "children": [ + 3810, + 3820, + 3809, + 3799, + 3819 + ], + "area": 2228044.60197, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 3799, + "strid": "c0d47f98-83f9-4bc9-b716-620d6b6fb019", + "image_id": 200657, + "image_name": "10488.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3349.325, + 690.399, + 1274.4920000000002, + 428.2130000000001 + ], + "priority": 22, + "parents": [ + 3794 + ], + "children": [], + "area": 2312370.6306749997, + "iscrowd": 0, + "segmentation": [], + "text": "The method has been implemented as a C++ multithreaded program. It can process\nlarge datasets of thousands of samples and millions of genes in few hours on a\nregular single node server..\n\nWe used it to structure the integrated catalog of reference genes of the human gut\nmicrobiome (IGC) [5]. Among the 9.9 million genes, 4.7 million with enough mapped\nreads and enough prevalence across the 1267 samples were kept.\n\n1068 Metagenomic Species Pan-genomes (MSP) with at least 200 genes in their core\ngenes set were discovered." + }, + { + "id": 3819, + "strid": "4ea240fc-3df8-4c62-a94e-2bca0377bb46", + "image_id": 200657, + "image_name": "10488.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3351.229, + 1145.075, + 639.1240000000003, + 425.4580000000001 + ], + "priority": 23, + "parents": [ + 3794 + ], + "children": [ + 3807 + ], + "area": 3837408.547175, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 3807, + "strid": "ddb1656b-b79c-44fa-aa79-55ebe3197246", + "image_id": 200657, + "image_name": "10488.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 4040.879, + 1245.508, + 559.5320000000002, + 81.53199999999993 + ], + "priority": 24, + "parents": [ + 3819 + ], + "children": [], + "area": 5032947.121532, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 5. Lowest taxonomic rank\nassigned to MSPs" + }, + { + "id": 3809, + "strid": "2b926afa-fb50-40fc-8872-75324937ce25", + "image_id": 200657, + "image_name": "10488.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4043.177, + 1327.834, + 554.2469999999998, + 120.40200000000004 + ], + "priority": 25, + "parents": [ + 3794 + ], + "children": [], + "area": 5368667.888618001, + "iscrowd": 0, + "segmentation": [], + "text": "Taxonomic annotation of MSPs was\nperformed by comparing core genes\nagainst KEGG GENES and RefSeq." + }, + { + "id": 3820, + "strid": "bf9aeed1-fca3-4d83-bab1-a735aa19fea2", + "image_id": 200657, + "image_name": "10488.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 3324.989, + 1630.51, + 719.7170000000001, + 491.057 + ], + "priority": 26, + "parents": [ + 3794 + ], + "children": [ + 3808 + ], + "area": 5421427.81439, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 3808, + "strid": "ed40063a-d98b-4dc7-932e-16abe977806c", + "image_id": 200657, + "image_name": "10488.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 4050.471, + 1675.548, + 594.7019999999998, + 84.72900000000004 + ], + "priority": 27, + "parents": [ + 3820 + ], + "children": [], + "area": 6786758.583108, + "iscrowd": 0, + "segmentation": [], + "text": "Figure 6. composition of MSPs matching\nknown species" + }, + { + "id": 3810, + "strid": "85675415-2be2-49e2-81d1-2e71646eeda0", + "image_id": 200657, + "image_name": "10488.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 4051.137, + 1759.689, + 594.0489999999995, + 245.779 + ], + "priority": 28, + "parents": [ + 3794 + ], + "children": [], + "area": 7128741.216393, + "iscrowd": 0, + "segmentation": [], + "text": "The method discovered very few new genes\nfor well-characterized species like E. coli that\nhave thousands of sequenced strains.\nHowever, many previously unknown\naccessory genes genes were discovered for\nspecies with just a few representatives." + }, + { + "id": 3795, + "strid": "79f6010e-05ab-47a3-b99e-c2780bae24c4", + "image_id": 200657, + "image_name": "10488.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3809.008, + 2227.556, + 355.6090000000004, + 74.08500000000004 + ], + "priority": 29, + "parents": [ + 3821 + ], + "children": [ + 3800 + ], + "area": 8484778.624448, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion" + }, + { + "id": 3800, + "strid": "87dc7b0f-173a-4ebe-9d6a-9601a45ac3b7", + "image_id": 200657, + "image_name": "10488.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3346.225, + 2337.459, + 1270.7069999999999, + 280.76200000000017 + ], + "priority": 30, + "parents": [ + 3795 + ], + "children": [], + "area": 7821663.742275, + "iscrowd": 0, + "segmentation": [], + "text": "Our approach enables an efficient and informative reconstitution of pan-genomes\nfrom shotgun metagenomic data without referring to genomes from isolated\nstrains. It gives an overview of the genetic variation of microbes in a given\necosystem. Identification of core genes sets and accessory modules can be used for\na more accurate counting of microbes abundance and their optional functional\nunits." + }, + { + "id": 3796, + "strid": "28fe695b-e320-4911-94bf-7f48e00512b1", + "image_id": 200657, + "image_name": "10488.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3815.723, + 2712.131, + 349.0779999999995, + 76.36099999999988 + ], + "priority": 31, + "parents": [ + 3821 + ], + "children": [ + 3812 + ], + "area": 10348740.635713, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 3812, + "strid": "f6f07930-59f5-452b-a72c-12865f72a197", + "image_id": 200657, + "image_name": "10488.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 3351.435, + 2823.882, + 1195.726, + 283.25199999999995 + ], + "priority": 32, + "parents": [ + 3796 + ], + "children": [], + "area": 9464056.97067, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 39479, + "strid": "4d142c09-c987-4070-a79c-3977b30b08e2", + "image_id": 202051, + "image_name": "118064.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 2120.53, + 129.5, + 203.73999999999978, + 211.89 + ], + "priority": -1, + "parents": [], + "children": [ + 39467, + 39465, + 39461, + 39463, + 39462, + 39466, + 39464, + 39460 + ], + "area": 274608.635, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 39460, + "strid": "19644a50-b9af-4a63-8fad-cfd044d5db72", + "image_id": 202051, + "image_name": "118064.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 170.111, + 155.212, + 1813.38, + 370.477 + ], + "priority": 1, + "parents": [ + 39479 + ], + "children": [], + "area": 26403.268532, + "iscrowd": 0, + "segmentation": [], + "text": "StatsDB: platform-agnostic storage and\nunderstanding of next generation\nsequencing run metrics" + }, + { + "id": 39461, + "strid": "07d3212d-0c5f-4bbb-a714-f6254d1ebe04", + "image_id": 202051, + "image_name": "118064.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 126.891, + 564.414, + 1907.818, + 121.63900000000001 + ], + "priority": 2, + "parents": [ + 39479 + ], + "children": [], + "area": 71619.056874, + "iscrowd": 0, + "segmentation": [], + "text": "Richard M. Leggett, Ricardo Ramirez-Gonzalez, Anil Thanki, Nizar Drou, Rob Davey\nThe Genome Analysis Centre (TGAC), Norwich, UK" + }, + { + "id": 39462, + "strid": "198a4f90-d05d-4e89-83ab-f0c18f917fbe", + "image_id": 202051, + "image_name": "118064.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 433.658, + 899.0, + 826.35, + 65.42100000000005 + ], + "priority": 3, + "parents": [ + 39479 + ], + "children": [ + 39468 + ], + "area": 389858.542, + "iscrowd": 0, + "segmentation": [], + "text": "1. Understanding data quality" + }, + { + "id": 39468, + "strid": "fc4343e3-25af-4d1a-b164-9312229ec013", + "image_id": 202051, + "image_name": "118064.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 100.923, + 1035.954, + 1487.961, + 795.8779999999999 + ], + "priority": 4, + "parents": [ + 39462 + ], + "children": [], + "area": 104551.585542, + "iscrowd": 0, + "segmentation": [], + "text": "Modern sequencing platforms generate enormous quantities of data in\never-decreasing amounts of time. With such data comes a significant\nchallenge to understand its quality and to understand how quality and\nyield are changing across instruments and over time. As well as the\ndesire to understand historical data, centres often have a duty to\nprovide clear summaries of individual run performance to collaborators\nor customers.\n\nWe present StatsDB, an open-source software package for storage and\nanalysis of next generation sequencing run metrics. The system has been\ndesigned for incorporation into the standard primary analysis pipeline\nof, for example, Illumina sequencers. Statistics are stored in an SQL\ndatabase and an API provides the ability to store and access the data\nwhile abstracting the underlying database design." + }, + { + "id": 39464, + "strid": "731c4070-c8f5-4b24-90eb-4afc640f64c1", + "image_id": 202051, + "image_name": "118064.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 527.063, + 1982.589, + 639.8060000000002, + 63.91799999999989 + ], + "priority": 5, + "parents": [ + 39479 + ], + "children": [ + 39471, + 39475 + ], + "area": 1044949.306107, + "iscrowd": 0, + "segmentation": [], + "text": "2. An extensible design" + }, + { + "id": 39471, + "strid": "1bed3e7b-45ab-4d5b-b7ff-0b2fe00b7ee3", + "image_id": 202051, + "image_name": "118064.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 105.174, + 2117.072, + 1486.403, + 169.69999999999982 + ], + "priority": 6, + "parents": [ + 39464 + ], + "children": [], + "area": 222660.93052800003, + "iscrowd": 0, + "segmentation": [], + "text": "Parsers process external data and use the statsDB API to write the data.\nConsumers query the data and present it to the user. We supply some\nparsers and consumers, but the API allows others to be simply produced." + }, + { + "id": 39475, + "strid": "f7b6e81c-48e9-4ff8-802d-6f6c7b23ad2c", + "image_id": 202051, + "image_name": "118064.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 276.946, + 2357.946, + 1152.4740000000002, + 839.221 + ], + "priority": 7, + "parents": [ + 39464 + ], + "children": [], + "area": 653023.712916, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 39465, + "strid": "52b603e7-c68b-4bf4-9e52-b49094a8a886", + "image_id": 202051, + "image_name": "118064.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 575.951, + 3349.349, + 532.376, + 68.94000000000005 + ], + "priority": 8, + "parents": [ + 39479 + ], + "children": [ + 39476 + ], + "area": 1929060.9058990001, + "iscrowd": 0, + "segmentation": [], + "text": "3. An open schema" + }, + { + "id": 39476, + "strid": "d877641e-e073-44ff-b06d-d047b2499857", + "image_id": 202051, + "image_name": "118064.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 310.491, + 3495.067, + 942.5149999999999, + 749.902 + ], + "priority": 9, + "parents": [ + 39465 + ], + "children": [], + "area": 1085186.847897, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 39463, + "strid": "cdfac32f-8492-4e6c-979c-c88ff91c1a0e", + "image_id": 202051, + "image_name": "118064.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2200.03, + 900.638, + 525.2910000000002, + 62.662000000000035 + ], + "priority": 10, + "parents": [ + 39479 + ], + "children": [ + 39470, + 39469 + ], + "area": 1981430.6191400003, + "iscrowd": 0, + "segmentation": [], + "text": "4. Database design" + }, + { + "id": 39469, + "strid": "15ec379d-3046-4316-972e-96192519766a", + "image_id": 202051, + "image_name": "118064.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1716.71, + 1035.357, + 1493.3490000000002, + 107.93399999999997 + ], + "priority": 11, + "parents": [ + 39463 + ], + "children": [], + "area": 1777407.71547, + "iscrowd": 0, + "segmentation": [], + "text": "The open schema allows support for multiple sequencing platforms and\nmultiple QC tools." + }, + { + "id": 39470, + "strid": "b78609e9-8538-4742-9369-ca8def164b8e", + "image_id": 202051, + "image_name": "118064.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1717.889, + 1183.51, + 1262.7450000000001, + 890.6969999999999 + ], + "priority": 12, + "parents": [ + 39463 + ], + "children": [], + "area": 2033138.8103899998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 39466, + "strid": "534e50ce-41f8-4b25-8668-5c9b1224cf68", + "image_id": 202051, + "image_name": "118064.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2143.962, + 2207.007, + 638.395, + 64.39699999999993 + ], + "priority": 13, + "parents": [ + 39479 + ], + "children": [ + 39477, + 39472 + ], + "area": 4731739.141734, + "iscrowd": 0, + "segmentation": [], + "text": "5. Access through LIMS" + }, + { + "id": 39472, + "strid": "01117f40-6606-40bc-a946-da20115e24c0", + "image_id": 202051, + "image_name": "118064.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1715.853, + 2341.367, + 1494.516, + 107.76299999999992 + ], + "priority": 14, + "parents": [ + 39466 + ], + "children": [], + "area": 4017441.5910510006, + "iscrowd": 0, + "segmentation": [], + "text": "MISO, the TGAC opensource LIMS system includes support for accessing\nand plotting QC information stored in StatsDB." + }, + { + "id": 39477, + "strid": "9306e56f-b420-4050-aa93-be777317a736", + "image_id": 202051, + "image_name": "118064.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1827.967, + 2493.886, + 1217.136, + 568.9389999999999 + ], + "priority": 15, + "parents": [ + 39466 + ], + "children": [], + "area": 4558741.309762, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 39467, + "strid": "458fc267-eed8-42a7-b319-3932bbf4da43", + "image_id": 202051, + "image_name": "118064.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1973.887, + 3221.698, + 983.3010000000002, + 69.39899999999989 + ], + "priority": 16, + "parents": [ + 39479 + ], + "children": [ + 39474, + 39473, + 39478 + ], + "area": 6359267.800125999, + "iscrowd": 0, + "segmentation": [], + "text": "6. Access through StatsDB Reporter" + }, + { + "id": 39473, + "strid": "472d29c2-a361-44b2-a135-bd3900237169", + "image_id": 202051, + "image_name": "118064.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1715.441, + 3357.507, + 1490.555, + 165.4920000000002 + ], + "priority": 17, + "parents": [ + 39467 + ], + "children": [], + "area": 5759605.165587001, + "iscrowd": 0, + "segmentation": [], + "text": "StatsDB Reporter is a Java tool that provides a GUI to query StatsDB,\nreport metrics and provide plots of relevant QC data. Multiple runs can\nbe selected and plotted on a single graph." + }, + { + "id": 39478, + "strid": "541cb789-42e6-4b51-bdeb-e54778c504c1", + "image_id": 202051, + "image_name": "118064.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2002.981, + 3565.98, + 923.037, + 557.0130000000004 + ], + "priority": 18, + "parents": [ + 39467 + ], + "children": [], + "area": 7142590.18638, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 39474, + "strid": "24a37e37-5a5d-4719-8ca8-4536e37da1ce", + "image_id": 202051, + "image_name": "118064.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1713.11, + 4163.588, + 1497.385, + 109.51900000000023 + ], + "priority": 19, + "parents": [ + 39467 + ], + "children": [], + "area": 7132684.2386799995, + "iscrowd": 0, + "segmentation": [], + "text": "We are in the process of designing other tools for querying StatsDB —\nthese include a command line tool for producing PDF reports." + }, + { + "id": 126742, + "strid": "00d6c342-7489-49a1-a348-405f36e99a01", + "image_id": 205436, + "image_name": "15130.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 42.37, + 180.34, + 146.69, + 472.68999999999994 + ], + "priority": -1, + "parents": [], + "children": [ + 126728, + 126724, + 126729, + 126723, + 126722, + 126730, + 126726, + 126725, + 126727 + ], + "area": 7641.0058, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 126722, + "strid": "968d65f5-23d1-4a92-a40c-7bc87fdc41ae", + "image_id": 205436, + "image_name": "15130.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 498.341, + 73.321, + 2324.982, + 236.62500000000003 + ], + "priority": 1, + "parents": [ + 126742 + ], + "children": [], + "area": 36538.860461, + "iscrowd": 0, + "segmentation": [], + "text": "scReClassify: post hoc cell type classification of\nsingle-cell RNA-seq data" + }, + { + "id": 126723, + "strid": "a965f4db-6b50-4abc-addf-a06011575b97", + "image_id": 205436, + "image_name": "15130.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 290.258, + 340.229, + 2734.441, + 393.708 + ], + "priority": 2, + "parents": [ + 126742 + ], + "children": [], + "area": 98754.18908199998, + "iscrowd": 0, + "segmentation": [], + "text": "Taiyun Kim\", Kitty Lo’?, Thomas A Geddes'2?, Hani Jieun Kim‘*4, Jean YH Yang’? and Pengyi Yang!**\n\n1§chool of Mathematics and Statistics, Faculty of Science, The University of Sydney, NSW 2006, Australia\n2School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, NSW 2006, Australia\n3Charles Perkins Centre, The University of Sydney, NSW 2006, Australia\n4 Computational Systems Biology Group, Children’s Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, NSW 2145, Australia\n* Corresponding author (pengyi.yang@Sydney.edu.au)\nAvailability https://github.com/SydneyBioX/scdney" + }, + { + "id": 126724, + "strid": "f14147e6-f901-4bc4-b12a-72f9c65fd892", + "image_id": 205436, + "image_name": "15130.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 37.866, + 804.355, + 270.637, + 58.27099999999996 + ], + "priority": 3, + "parents": [ + 126742 + ], + "children": [ + 126735 + ], + "area": 30457.706430000002, + "iscrowd": 0, + "segmentation": [], + "text": "Highlights" + }, + { + "id": 126735, + "strid": "5861f84f-50ff-4dc9-83a2-5254a547ae05", + "image_id": 205436, + "image_name": "15130.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 38.246, + 870.759, + 1788.158, + 365.71399999999994 + ], + "priority": 4, + "parents": [ + 126724 + ], + "children": [], + "area": 33303.048714000004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 126725, + "strid": "79a07226-98ea-432e-957e-1d10cf6803ba", + "image_id": 205436, + "image_name": "15130.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 36.656, + 1304.203, + 275.435, + 46.81600000000003 + ], + "priority": 5, + "parents": [ + 126742 + ], + "children": [ + 126731 + ], + "area": 47806.865168, + "iscrowd": 0, + "segmentation": [], + "text": "Motivation" + }, + { + "id": 126731, + "strid": "0e815454-7e29-4228-9bdd-34af3661c320", + "image_id": 205436, + "image_name": "15130.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 31.609, + 1370.688, + 1795.031, + 269.2180000000001 + ], + "priority": 6, + "parents": [ + 126725 + ], + "children": [], + "area": 43326.076992, + "iscrowd": 0, + "segmentation": [], + "text": "Cell type identification from scRNA-seq data is a critical task. Due to incompleteness of our\ncurrent knowledge and the subjectivity involved during human inspection in the process of\ncell type identification, a small amount of cells may be subject to mislabeling. We propose\nsemi-supervised learning framework, scReClassify, for post hoc cell type classification to\nfine-tune annotations generated by any cell type classification from scRNA-seq." + }, + { + "id": 126726, + "strid": "37cf4c49-7d91-4c82-871b-9958b521ae50", + "image_id": 205436, + "image_name": "15130.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 35.461, + 1701.387, + 660.467, + 55.97199999999998 + ], + "priority": 7, + "parents": [ + 126742 + ], + "children": [ + 126738, + 126736 + ], + "area": 60332.884407, + "iscrowd": 0, + "segmentation": [], + "text": "scReClassify Framework" + }, + { + "id": 126738, + "strid": "c84b5897-10ef-4ca4-86bb-4766fac56f7a", + "image_id": 205436, + "image_name": "15130.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 19.955, + 1774.111, + 1757.337, + 546.5399999999997 + ], + "priority": 8, + "parents": [ + 126726 + ], + "children": [], + "area": 35402.385005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 126736, + "strid": "91a4eede-7663-401c-bf94-d0b43cc53e13", + "image_id": 205436, + "image_name": "15130.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 40.312, + 2350.378, + 1792.467, + 98.86599999999999 + ], + "priority": 9, + "parents": [ + 126726 + ], + "children": [], + "area": 94748.437936, + "iscrowd": 0, + "segmentation": [], + "text": "(A) Typical cell type identification procedure. (B) scReClassify framework in which the method learns\nfrom dimension reduced gene expression matrix and reclassify cells via AdaSampling [1] procedure." + }, + { + "id": 126727, + "strid": "e72ed36b-57d8-4c4e-8ae6-cdd671926250", + "image_id": 205436, + "image_name": "15130.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 51.285, + 2504.207, + 853.491, + 49.327999999999975 + ], + "priority": 10, + "parents": [ + 126742 + ], + "children": [ + 126737, + 126739 + ], + "area": 128428.25599499998, + "iscrowd": 0, + "segmentation": [], + "text": "Evaluation on simulated dataset" + }, + { + "id": 126739, + "strid": "2af5687f-24f0-438b-b4c4-0b5066646a60", + "image_id": 205436, + "image_name": "15130.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 44.494, + 2569.869, + 1669.507, + 552.3319999999999 + ], + "priority": 11, + "parents": [ + 126727 + ], + "children": [], + "area": 114343.751286, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 126737, + "strid": "f5d8bc06-8e8d-4ffe-bca6-c2cbef117ec6", + "image_id": 205436, + "image_name": "15130.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 47.184, + 3135.743, + 1747.762, + 97.67900000000009 + ], + "priority": 12, + "parents": [ + 126727 + ], + "children": [], + "area": 147956.89771199998, + "iscrowd": 0, + "segmentation": [], + "text": "(A) Simulated scRNA-seq data with 20% of mislabelled cells (open ring), and (B) ‘reclassified’ results\nusing either SVM and RF using scReClassify." + }, + { + "id": 126728, + "strid": "e76ab6a7-9903-4ff7-b197-3025d8769d8a", + "image_id": 205436, + "image_name": "15130.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 49.759, + 3318.677, + 1631.608, + 63.871000000000095 + ], + "priority": 13, + "parents": [ + 126742 + ], + "children": [ + 126732, + 126740 + ], + "area": 165134.048843, + "iscrowd": 0, + "segmentation": [], + "text": "Evaluation on real datasets with varying degree of label noise" + }, + { + "id": 126740, + "strid": "10e60692-2d8a-4656-aefb-824bf01889b5", + "image_id": 205436, + "image_name": "15130.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 52.06, + 3404.435, + 1753.39, + 720.1749999999997 + ], + "priority": 14, + "parents": [ + 126728 + ], + "children": [], + "area": 177234.8861, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 126732, + "strid": "3360405c-feb0-4844-abe9-3a23cae45ef6", + "image_id": 205436, + "image_name": "15130.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 44.739, + 4137.598, + 1752.385, + 187.98700000000008 + ], + "priority": 15, + "parents": [ + 126728 + ], + "children": [], + "area": 185111.996922, + "iscrowd": 0, + "segmentation": [], + "text": "Mean accuracy calculated from the ground truth and the synthetically mislabelled annotations with\nvarying percentages of noise (denoted by p) for each scRNA-seq dataset with a different number of\ncell types. Performance of scReClassify are shown as boxes coloured according to the percentages\n\nof mislabelled cells." + }, + { + "id": 126730, + "strid": "b137350a-2d14-4d63-a752-8b8e56fc9e63", + "image_id": 205436, + "image_name": "15130.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1899.646, + 815.902, + 1167.2660000000003, + 58.07299999999998 + ], + "priority": 16, + "parents": [ + 126742 + ], + "children": [ + 126741, + 126734 + ], + "area": 1549924.9706920001, + "iscrowd": 0, + "segmentation": [], + "text": "Marker gene expression of reclassified cells" + }, + { + "id": 126741, + "strid": "ebeec08f-256b-42be-87e8-8cf8132c7c5e", + "image_id": 205436, + "image_name": "15130.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1887.958, + 908.081, + 1380.2469999999998, + 3298.6899999999996 + ], + "priority": 17, + "parents": [ + 126730 + ], + "children": [], + "area": 1714418.788598, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 126734, + "strid": "b577956b-3158-409f-8ff4-d6ee00995636", + "image_id": 205436, + "image_name": "15130.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1897.735, + 4226.672, + 1380.169, + 378.46399999999994 + ], + "priority": 18, + "parents": [ + 126730 + ], + "children": [], + "area": 8021103.387919999, + "iscrowd": 0, + "segmentation": [], + "text": "Comparison of gene expression levels of reclassified cells using cell type\nspecific markers for early human development dataset (E-MTAB-3929) (A) and\nfetal liver development dataset (GSE87795) (B). We applied scReClassify on\ndatasets (A) and (B) with their published cell type annotations. Log transformed\nexpression values (y-axis) of reclassified cells (red dot) in cell type specific\nmarker genes shows higher correspondence to its corrected cell type\nexpression distribution (highlighted by red arrow) as oppose to distribution of its\noriginal cell type’s expression (highlighted by black arrow)." + }, + { + "id": 126729, + "strid": "0ceed4b0-d603-4d92-9318-8ef3ca4b56e7", + "image_id": 205436, + "image_name": "15130.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 34.166, + 4381.272, + 926.5410000000002, + 63.7529999999997 + ], + "priority": 19, + "parents": [ + 126742 + ], + "children": [ + 126733 + ], + "area": 149690.53915199998, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgement and References" + }, + { + "id": 126733, + "strid": "a5548172-917f-4e27-8744-422d31759dbd", + "image_id": 205436, + "image_name": "15130.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 31.346, + 4448.724, + 1337.358, + 169.30199999999968 + ], + "priority": 20, + "parents": [ + 126729 + ], + "children": [], + "area": 139449.70250400002, + "iscrowd": 0, + "segmentation": [], + "text": "This work is supported by an Australian Research Council (ARC)/Discovery Early Career researcher\nAward (DE170100759) to P.Y., a National Health and Medical Research Council (NHMRC)/Career\nDevelopment Fellowship (1105271) to J.Y.H.Y., an ARC/Discovery Project (DP170100654) grant to P.Y.\nand J.Y.H.Y., and a Cardio Precision Medicine Coffey Scholarship to T.K.\n\n[1] Yang et al.,(2019) IEEE Transactions on Cybernetics, 49(5), 1932-1943" + }, + { + "id": 35944, + "strid": "f86a1316-6655-4da1-8b64-cbc9205692fc", + "image_id": 201918, + "image_name": "117873.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 32.96, + 31, + 170.01, + 170.02 + ], + "priority": -1, + "parents": [], + "children": [ + 35930, + 35935, + 35934, + 35933, + 35931, + 35929, + 35928, + 35932 + ], + "area": 1021.76, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 35928, + "strid": "bbd8ab28-8307-45a1-acd8-9b6c1934f42a", + "image_id": 201918, + "image_name": "117873.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 360.069, + 132.526, + 2553.019, + 227.67400000000004 + ], + "priority": 1, + "parents": [ + 35944 + ], + "children": [], + "area": 47718.504294000006, + "iscrowd": 0, + "segmentation": [], + "text": "ee Exploring Bioinformatics’\nDatabase and Software Use through Literature Mining" + }, + { + "id": 35929, + "strid": "f2ebcff5-1e0e-4944-b673-792ac8034b2e", + "image_id": 201918, + "image_name": "117873.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 896.058, + 431.022, + 1551.091, + 252.16900000000004 + ], + "priority": 2, + "parents": [ + 35944 + ], + "children": [], + "area": 386220.711276, + "iscrowd": 0, + "segmentation": [], + "text": "Geraint Duck*, Andy Brass, Goran Nenadic,\nDavid L. Robertson and Robert Stevens\nThe University of Manchester, UK" + }, + { + "id": 35930, + "strid": "ac58c777-f0b2-4683-af8f-0edb4ecd50b7", + "image_id": 201918, + "image_name": "117873.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 157.47, + 757.82, + 437.16999999999996, + 72.63700000000006 + ], + "priority": 3, + "parents": [ + 35944 + ], + "children": [ + 35936 + ], + "area": 119333.91540000001, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 35936, + "strid": "ade67c4d-7418-4532-9a7e-12b4af3c8657", + "image_id": 201918, + "image_name": "117873.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 144.537, + 902.995, + 1318.578, + 749.0089999999999 + ], + "priority": 4, + "parents": [ + 35930 + ], + "children": [], + "area": 130516.188315, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 35931, + "strid": "1be56042-f80a-443e-9df1-f69815166638", + "image_id": 201918, + "image_name": "117873.png", + "category_id": 5, + 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The Swiss Institute of bioscience\nBioinformatics provided a stipend for travel to ECCB 2012." + }, + { + "id": 140119, + "strid": "09ac4b7d-e79c-4379-8a49-c9e944118b07", + "image_id": 205947, + "image_name": "16797.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 2552.48, + 452.55, + 261.80999999999995, + 217.10999999999996 + ], + "priority": -1, + "parents": [], + "children": [ + 140104, + 140106, + 140103, + 140102, + 140109, + 140107, + 140105, + 140108 + ], + "area": 1155124.824, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 140102, + "strid": "5f1c9aab-1319-47dc-aa9e-2d109aee17f3", + "image_id": 205947, + "image_name": "16797.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 133.577, + 51.907, + 2323.371, + 206.399 + ], + "priority": 1, + "parents": [ + 140119 + ], + "children": [], + "area": 6933.581338999999, + "iscrowd": 0, + "segmentation": [], + "text": "Full-length transcriptome reconstruction reveals a large\ndiversity of RNA and protein isoforms in rat hippocampus" + }, + { + "id": 140103, + "strid": "b8ac9ae4-642e-4597-bc75-6114002c7e1a", + "image_id": 205947, + "image_name": "16797.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 136.347, + 273.567, + 2288.038, + 347.0419999999999 + ], + "priority": 2, + "parents": [ + 140119 + ], + "children": [], + "area": 37300.039749, + "iscrowd": 0, + "segmentation": [], + "text": "Xi Wang‘, Xintian You*?, Julian D. Langer’, Jingyi Hou?, Fiona Rupprecht*, Irena Viatkovic*, Claudia Se\nErin M. Schuman* & Wei Chen®\n\n1 German Cancer Research Center (DKFZ), Heidelberg, Germany; 2 Max Delbruck Center for Molecular Mediciné°*°\nBerlin, Germany; * Max Planck Institute for Molecular Genetics, Berlin, Germany; * Max Planck Institute for Brain\n\nResearch, Frankfurt, Germany; ° Department of Biology, Southern University of Science and Technology, Shenzhen,\nGuangdong, China" + }, + { + "id": 140104, + "strid": "9389bd8c-3461-4790-9a93-26c2fe545c68", + "image_id": 205947, + "image_name": "16797.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 165.593, + 729.038, + 1064.478, + 162.33299999999997 + ], + "priority": 3, + "parents": [ + 140119 + ], + "children": [ + 140110 + ], + "area": 120723.589534, + "iscrowd": 0, + "segmentation": [], + "text": "The necessity of full-length\ntranscriptome reconstruction" + }, + { + "id": 140110, + "strid": "ac25266a-47e0-4f9b-9484-874fb0ccc288", + "image_id": 205947, + "image_name": "16797.png", + "category_id": 4, + 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"area": 1308889.1252700002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 140108, + "strid": "ff3f7dc1-ec26-42ec-80ee-cea17f6c4de0", + "image_id": 205947, + "image_name": "16797.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1583.965, + 1607.029, + 713.8340000000001, + 79.86300000000006 + ], + "priority": 12, + "parents": [ + 140119 + ], + "children": [ + 140116, + 140117, + 140112 + ], + "area": 2545477.689985, + "iscrowd": 0, + "segmentation": [], + "text": "ORFeome diversity" + }, + { + "id": 140116, + "strid": "f4dbafa2-658d-483f-b37a-ddf83fe80b62", + "image_id": 205947, + "image_name": "16797.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1502.862, + 1745.567, + 880.663, + 600.2260000000001 + ], + "priority": 13, + "parents": [ + 140108 + ], + "children": [], + "area": 2623346.312754, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 140112, + "strid": "5e48cb60-909e-4fde-9274-f65eccbe249b", + "image_id": 205947, + 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"image_id": 206072, + "image_name": "17322.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 257.074, + 15.766, + 2293.068, + 187.091 + ], + "priority": 1, + "parents": [ + 143367 + ], + "children": [], + "area": 4053.0286840000003, + "iscrowd": 0, + "segmentation": [], + "text": "Structural model for recruitment of RIT1 to the LZTR1 E83 ligase:\nevidences from an integrated computational approach" + }, + { + "id": 143334, + "strid": "9b90a11a-f9a4-4b3c-9485-17e64e396e07", + "image_id": 206072, + "image_name": "17322.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 420.179, + 205.256, + 1870.9139999999998, + 139.119 + ], + "priority": 2, + "parents": [ + 143367 + ], + "children": [], + "area": 86244.260824, + "iscrowd": 0, + "segmentation": [], + "text": "Antonella Paladino' , Michele Ceccarelli'2\n1 BIOGEM, Istituto di Ricerche Genetiche 'G. Salvatore‘ via Camporeale, 83031 Ariano Irpino, AV\n2 Dipartimento di Ingegneria Elettrica e delle Tecnologie dell’ Informazione (DIETI) Universita degli Studi di Napoli \"Federico II”" + }, + { + "id": 143335, + "strid": "76688bc2-4408-4c5f-8611-5461a3d452fe", + "image_id": 206072, + "image_name": "17322.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 40.502, + 370.553, + 2305.625, + 479.31399999999996 + ], + "priority": 3, + "parents": [ + 143367 + ], + "children": [], + "area": 15008.137606, + "iscrowd": 0, + "segmentation": [], + "text": "Leucine-zipper transcription Regulator 1 (LZTR1) is a highly mutated tumor suppressor gene, involved in the pathogenesis of\nseveral cancers and developmental disorders.' In proteasomal degradation, it acts as an adaptor protein responsible for the\nrecognition and recruitment of substrates to be ubiquitinated in Cullin3-RING ligase E3 (CRL3) machinery.\n\nA small Ras-related GTPase protein, RIT1, has been recently identified by mass spectroscopy to interact with LZTR1.? Moreover,\nlarge efforts mutational analyses pointed to the role of disease-associated LZTR1 mutations in RAS/MAPK signaling pathway.\nNo experimental three-dimensional structure is available for the multi-domain LZTR1 protein, a BTB-Kelch family member, with the\nKelch propeller domain acting as the substrate recognition region. Here we propose the interaction model between adaptor LZTR1\nand substrate RIT1 applying an integrated computational approach, build on molecular modelling and docking techniques.*” By MD-\nbased analyses, we also characterize differential conformational dynamics of the multi-domain LZTR1, offering interesting\nimplications on the mechanistic role of specific point mutations.®" + }, + { + "id": 143366, + "strid": "ea7d4139-55de-4175-a303-bf292fadafd7", + "image_id": 206072, + "image_name": "17322.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2378.184, + 445.317, + 754.9079999999999, + 442.568 + ], + "priority": 4, + "parents": [ + 143367 + ], + "children": [], + "area": 1059045.7643280001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143336, + "strid": "138bd1b7-023d-4e55-81be-9528b5bda459", + "image_id": 206072, + "image_name": "17322.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 47.715, + 879.123, + 731.25, + 53.32000000000005 + ], + "priority": 5, + "parents": [ + 143367 + ], + "children": [ + 143345, + 143346, + 143340, + 143344, + 143341, + 143347, + 143342, + 143343, + 143348 + ], + "area": 41947.353945, + "iscrowd": 0, + "segmentation": [], + "text": "Modelling LZTR1-RIT1 interaction" + }, + { + "id": 143340, + "strid": "212ea653-e604-441f-9700-8038a88d2cff", + "image_id": 206072, + "image_name": "17322.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 63.989, + 969.104, + 745.549, + 47.42399999999998 + ], + "priority": 6, + "parents": [ + 143336 + ], + "children": [], + "area": 62011.995856, + "iscrowd": 0, + "segmentation": [], + "text": "1. LZTR1 3D structure by homology modelling" + }, + { + "id": 143341, + "strid": "ac67699a-abc6-49a2-b3eb-25f152d87da6", + "image_id": 206072, + "image_name": "17322.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 28.976, + 1058.053, + 1363.286, + 612.713 + ], + "priority": 7, + "parents": [ + 143336 + ], + "children": [], + "area": 30658.143728000003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143344, + "strid": "4a2bbd5a-6272-473f-816b-25e0c8a4ebc2", + "image_id": 206072, + "image_name": "17322.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 33.167, + 1699.906, + 1396.732, + 239.913 + ], + "priority": 8, + "parents": [ + 143336 + ], + "children": [], + "area": 56380.782302, + "iscrowd": 0, + "segmentation": [], + "text": "Sequence alignments returns a Kelch six-bladed (aka repeats) B-propeller motif at the N-term and two\nBTB-back domains at the C-term. A multi-template model of the full-length LZTR1 was built by Modeller,\nusing the Kelch domain of the thiocyanate-forming protein from Thlaspi Arvense (pdb: 5A10) for the\nKelch domain and the human SPOP-BTB domain (pdb: 4J8Z) for the BTB domains.\n\nFull-length LZTR1 folds in an elongated structure made by three well-separated structural blocks." + }, + { + "id": 143342, + "strid": "36a19b78-e659-4f43-b14b-f92c111d1e0b", + "image_id": 206072, + "image_name": "17322.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1462.097, + 974.622, + 563.8509999999999, + 562.3160000000001 + ], + "priority": 9, + "parents": [ + 143336 + ], + "children": [], + "area": 1424991.902334, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143343, + "strid": "c361073f-eb99-4134-9a29-fb4fca221370", + "image_id": 206072, + "image_name": "17322.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1462.549, + 1547.675, + 562.653, + 424.827 + ], + "priority": 10, + "parents": [ + 143336 + ], + "children": [], + "area": 2263550.523575, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143345, + "strid": "a9e0bbc7-a000-465a-8799-686aa75708ec", + "image_id": 206072, + "image_name": "17322.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2318.192, + 970.575, + 377.26099999999997, + 43.236999999999966 + ], + "priority": 11, + "parents": [ + 143336 + ], + "children": [], + "area": 2249979.2004, + "iscrowd": 0, + "segmentation": [], + "text": "2. LZTR1-RIT1 docking" + }, + { + "id": 143346, + "strid": "6d61060f-6e09-486e-b31f-b55195b90e45", + "image_id": 206072, + "image_name": "17322.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2033.823, + 1014.391, + 930.2, + 386.88199999999995 + ], + "priority": 12, + "parents": [ + 143336 + ], + "children": [], + "area": 2063091.746793, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143347, + "strid": "ed386f9c-e839-4897-8dcd-c1eabc828626", + "image_id": 206072, + "image_name": "17322.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2353.422, + 1298.665, + 790.5859999999998, + 126.15699999999993 + ], + "priority": 13, + "parents": [ + 143336 + ], + "children": [], + "area": 3056306.78163, + "iscrowd": 0, + "segmentation": [], + "text": "Mutational data of both LZTR1 and RIT1 have been used to guide\nthe selection among the best-ranked models predicted by\n\ndifferent docking software (ClusPro, Zdock, PatchDock, Frodock)" + }, + { + "id": 143348, + "strid": "d921cd03-a3db-47f4-8742-b4880b6679b3", + "image_id": 206072, + "image_name": "17322.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2242.889, + 1430.367, + 864.4340000000002, + 486.5150000000001 + ], + "priority": 14, + "parents": [ + 143336 + ], + "children": [], + "area": 3208154.410263, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143337, + "strid": "4b5d79e1-5d3b-4ae7-834f-8d1662c02e57", + "image_id": 206072, + "image_name": "17322.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 45.666, + 1987.327, + 859.9470000000001, + 57.24299999999994 + ], + "priority": 15, + "parents": [ + 143367 + ], + "children": [ + 143352, + 143354, + 143349, + 143351, + 143357, + 143356, + 143355, + 143350, + 143353 + ], + "area": 90753.274782, + "iscrowd": 0, + "segmentation": [], + "text": "Mutational scanning for MD simulations" + }, + { + "id": 143349, + "strid": "782401e2-4324-45e7-9098-9accca019042", + "image_id": 206072, + "image_name": "17322.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 44.647, + 2098.358, + 468.89000000000004, + 43.03099999999995 + ], + "priority": 16, + "parents": [ + 143337 + ], + "children": [], + "area": 93685.389626, + "iscrowd": 0, + "segmentation": [], + "text": "1. Foldx mutational analysis" + }, + { + "id": 143350, + "strid": "32f45e1d-b47d-445c-b4ab-3dde687c4964", + "image_id": 206072, + "image_name": "17322.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 52.349, + 2148.031, + 1051.046, + 570.5680000000002 + ], + "priority": 17, + "parents": [ + 143337 + ], + "children": [], + "area": 112447.27481899998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143351, + "strid": "5d519362-f7a9-40f0-9922-eb3ff41e62c4", + "image_id": 206072, + "image_name": "17322.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 37.424, + 2736.96, + 1037.948, + 189.26400000000012 + ], + "priority": 18, + "parents": [ + 143337 + ], + "children": [], + "area": 102427.99104, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143352, + "strid": "64aa5f90-0618-413f-83ef-e72ae56bb549", + "image_id": 206072, + "image_name": "17322.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1305.393, + 2165.742, + 851.5280000000002, + 523.69 + ], + "priority": 19, + "parents": [ + 143337 + ], + "children": [], + "area": 2827144.4466060004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143353, + "strid": "e501b878-fb32-4123-8e39-081a454ac166", + "image_id": 206072, + "image_name": "17322.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1254.302, + 2729.879, + 919.6499999999999, + 191.59400000000005 + ], + "priority": 20, + "parents": [ + 143337 + ], + "children": [], + "area": 3424092.6894579995, + "iscrowd": 0, + "segmentation": [], + "text": "R283 and R412 make ionic interactions with RIT1 in starting complex.\nPathogenicity predictions performed for 252 missense LZTR1 mutations\nretrieved from COSMIC and TCGA databases score G248R, R283Q and R412C\n\namong the most damaging variants of the Kelch domain." + }, + { + "id": 143354, + "strid": "80308e0a-545b-4fcb-9a91-f170cf9d9f64", + "image_id": 206072, + "image_name": "17322.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2253.473, + 2099.438, + 307.73799999999983, + 45.25500000000011 + ], + "priority": 21, + "parents": [ + 143337 + ], + "children": [], + "area": 4731026.848174, + "iscrowd": 0, + "segmentation": [], + "text": "2. MD simulations" + }, + { + "id": 143355, + "strid": "33db0825-37bc-4422-9558-8b561ac20892", + "image_id": 206072, + "image_name": "17322.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2252.611, + 2193.828, + 810.2889999999998, + 103.4409999999998 + ], + "priority": 22, + "parents": [ + 143337 + ], + "children": [], + "area": 4941841.084907999, + "iscrowd": 0, + "segmentation": [], + "text": "run on LZTR1 in its wild-type and mutated sequences,\n\nin its apo form and in complex with RIT1" + }, + { + "id": 143356, + "strid": "843a6896-1c17-4a98-9683-586c219524a4", + "image_id": 206072, + "image_name": "17322.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2237.526, + 2359.765, + 833.9949999999999, + 196.10699999999997 + ], + "priority": 23, + "parents": [ + 143337 + ], + "children": [], + "area": 5280035.541389999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143357, + "strid": "e4e8e13c-0fe3-483d-8e7c-98c7bee6f490", + "image_id": 206072, + "image_name": "17322.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2259.077, + 2609.748, + 685.2979999999998, + 265.06799999999976 + ], + "priority": 24, + "parents": [ + 143337 + ], + "children": [], + "area": 5895621.682596001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143338, + "strid": "010e0be1-7839-44ce-8863-2347277eebc9", + "image_id": 206072, + "image_name": "17322.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 45.448, + 2970.68, + 864.397, + 61.05400000000009 + ], + "priority": 25, + "parents": [ + 143367 + ], + "children": [ + 143359, + 143358, + 143362, + 143360, + 143363, + 143361 + ], + "area": 135011.46464, + "iscrowd": 0, + "segmentation": [], + "text": "Modulation of conformational dynamics" + }, + { + "id": 143358, + "strid": "52675463-231c-4271-b617-1ed470428c96", + "image_id": 206072, + "image_name": "17322.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 37.38, + 3065.95, + 1120.032, + 793.6350000000002 + ], + "priority": 26, + "parents": [ + 143338 + ], + "children": [], + "area": 114605.211, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143359, + "strid": "a1ec2998-192d-40e6-a690-e1350fdca0d1", + "image_id": 206072, + "image_name": "17322.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 41.003, + 3862.88, + 1104.574, + 183.55999999999995 + ], + "priority": 27, + "parents": [ + 143338 + ], + "children": [], + "area": 158389.66864000002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143360, + "strid": "67ac86d6-d99e-4fcb-821b-1400da440120", + "image_id": 206072, + "image_name": "17322.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1182.478, + 3159.267, + 213.7460000000001, + 500.933 + ], + "priority": 28, + "parents": [ + 143338 + ], + "children": [], + "area": 3735763.723626, + "iscrowd": 0, + "segmentation": [], + "text": "Structural\nrepresentation of\nthe first cluster\nper MD\nsimulation:\n\n1) wild-type,\n\n2) G248R;\n\n3) R283Q;\n\n4) R412C.\n\nIn each panel,\na-b) centroids of\nbound-LZTR1 in\nthe two runs and\nc-d) of free-\nLZTR1." + }, + { + "id": 143361, + "strid": "b4221a42-9364-41f4-b582-53c28f5ca19d", + "image_id": 206072, + "image_name": "17322.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1452.69, + 3068.151, + 1511.4990000000003, + 636.7489999999998 + ], + "priority": 29, + "parents": [ + 143338 + ], + "children": [], + "area": 4457072.27619, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143363, + "strid": "08b0c8e0-1709-4d1d-92e3-fe66f40a73ce", + "image_id": 206072, + "image_name": "17322.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1461.293, + 3765.415, + 1512.9890000000003, + 240.3180000000002 + ], + "priority": 30, + "parents": [ + 143338 + ], + "children": [], + "area": 5502374.581595, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 143362, + "strid": "04f194f8-abca-410d-89e9-e7e0894c4b2e", + "image_id": 206072, + "image_name": "17322.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2978.541, + 3237.188, + 141.4340000000002, + 470.44500000000016 + ], + "priority": 31, + "parents": [ + 143338 + ], + "children": [], + "area": 9642097.182708, + "iscrowd": 0, + "segmentation": [], + "text": "COM\ndistance\nbetween\nthe two\nBTB-back\ndomains in\nthe free\nLZTR1\nstate (left)\nand in\nLZTR1-\nRIT1\ncomplexes\n(right)." + }, + { + "id": 143339, + "strid": "88b98bca-f76b-4cd1-ae3a-0bffc20ab504", + "image_id": 206072, + "image_name": "17322.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 59.388, + 4068.309, + 629.441, + 56.926000000000386 + ], + "priority": 32, + "parents": [ + 143367 + ], + "children": [ + 143364 + ], + "area": 241608.734892, + "iscrowd": 0, + "segmentation": [], + "text": "CONCLUDING REMARKS" + }, + { + "id": 143364, + "strid": "5ebeaf20-df6f-4549-9a63-862fb93a558f", + "image_id": 206072, + "image_name": "17322.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 41.199, + 4129.606, + 2105.097, + 381.1999999999998 + ], + "priority": 33, + "parents": [ + 143339 + ], + "children": [], + "area": 170135.63759399997, + "iscrowd": 0, + "segmentation": [], + "text": "The structural characterization of the interaction between the adaptor protein LZTR1 and its substrate RIT1 allows to identify key residues\nresponsible for the recognition process. Our simulations show that LZTR1, both in the free and complexed state, experiences large structural\nmovements and inter-domain fluctuations. While inducing a minimal repositioning of RIT1, pathogenic point mutations at the Kelch top face\nimpact LZTR1 dynamics. In particular, R412C mutant significantly limits LZTR1 conformational variability, in either the free or bound form,\nsuggesting a contribution not limited to the recognition mechanism. Our findings yield a mechanistic hypothesis on the role of pathogenic\nmutations in the recognition patterns and in the functional dynamics at the basis of E3 ubiquitin activity,2 thus providing fundamental\nopportunities for drug development." + }, + { + "id": 143365, + "strid": "d52d0aef-6b14-4be2-9643-0e53fc8c5879", + "image_id": 206072, + "image_name": "17322.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2166.092, + 4113.404, + 966.5830000000001, + 344.7439999999997 + ], + "priority": 34, + "parents": [ + 143367 + ], + "children": [], + "area": 8910011.497168, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 4674, + "strid": "8fbe23c0-d32f-4879-a3b7-234b60007f65", + "image_id": 200693, + "image_name": "10629.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 2376.89, + 108.93, + 198.09000000000015, + 186.76 + ], + "priority": -1, + "parents": [], + "children": [ + 4655, + 4657, + 4651, + 4658, + 4654, + 4652, + 4656, + 4653 + ], + "area": 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and Lung Disease; 7London School of Hygiene and Tropical Medicine." + }, + { + "id": 4653, + "strid": "39625ab3-4689-4b59-bde7-7451d23bc99b", + "image_id": 200693, + "image_name": "10629.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 688.639, + 907.708, + 307.605, + 57.18799999999999 + ], + "priority": 3, + "parents": [ + 4674 + ], + "children": [ + 4669, + 4659 + ], + "area": 625083.129412, + "iscrowd": 0, + "segmentation": [], + "text": "Background" + }, + { + "id": 4659, + "strid": "066c202b-6052-472b-aa42-42ad359d2a57", + "image_id": 200693, + "image_name": "10629.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 158.173, + 1015.683, + 1356.895, + 141.76499999999987 + ], + "priority": 4, + "parents": [ + 4653 + ], + "children": [], + "area": 160653.627159, + "iscrowd": 0, + "segmentation": [], + "text": "To curb the influx of migrants/refugees, during 2015 and 2016, European\ncountries instituted restrictive migration policies often characterized by building\nof razor-wire border fences and border closures." + }, + { + "id": 4669, + "strid": "66405283-2119-4456-8417-9dde2325b10f", + "image_id": 200693, + "image_name": "10629.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 148.488, + 1193.562, + 1379.58, + 1182.0990000000002 + ], + "priority": 5, + "parents": [ + 4653 + ], + "children": [], + "area": 177229.634256, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 4654, + "strid": "244316e4-1c1c-4825-aab7-735bb7cd6bda", + "image_id": 200693, + "image_name": "10629.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1785.517, + 909.159, + 423.048, + 55.813999999999965 + ], + "priority": 6, + "parents": [ + 4674 + ], + "children": [ + 4666, + 4670, + 4660 + ], + "area": 1623318.850203, + "iscrowd": 0, + "segmentation": [], + "text": "Study objectives" + }, + { + "id": 4660, + "strid": "fc55de07-17a6-4c3b-96fe-601db19a7e22", + "image_id": 200693, + "image_name": "10629.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1585.624, + 1027.355, + 796.9469999999999, + 186.7840000000001 + ], + "priority": 7, + "parents": [ + 4654 + ], + "children": [], + "area": 1628998.74452, + "iscrowd": 0, + "segmentation": [], + "text": "Among migrants/refugees who received mental\nhealth care, and who were traveling along the\n\nBalkan route to Northern Europe we report\non:" + }, + { + "id": 4666, + "strid": "11b4e615-19ae-4df7-800d-36ba138daa47", + "image_id": 200693, + "image_name": "10629.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1589.231, + 1275.958, + 817.6900000000003, + 440.721 + ], + "priority": 8, + "parents": [ + 4654 + ], + "children": [], + "area": 2027792.008298, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 4670, + "strid": "44c75f84-1a01-4825-a355-ec9b30d9c089", + "image_id": 200693, + "image_name": "10629.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1586.418, + 1751.118, + 815.5260000000001, + 619.268 + ], + "priority": 9, + "parents": [ + 4654 + ], + "children": [], + "area": 2778005.115324, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 4655, + "strid": "7884e9a0-6285-47b5-b6ef-5b4ee493cbb5", + "image_id": 200693, + "image_name": "10629.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2677.899, + 911.286, + 221.5079999999998, + 42.11800000000005 + ], + "priority": 10, + "parents": [ + 4674 + ], + "children": [ + 4671, + 4662, + 4663, + 4664, + 4661 + ], + "area": 2440331.8681139997, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 4661, + "strid": "5b9e0042-7999-4bdb-b230-61de3850e613", + "image_id": 200693, + "image_name": "10629.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2464.137, + 1027.109, + 551.953, + 47.59999999999991 + ], + "priority": 11, + "parents": [ + 4655 + ], + "children": [], + "area": 2530937.2899329998, + "iscrowd": 0, + "segmentation": [], + "text": "Design: A cross-sectional study" + }, + { + "id": 4662, + "strid": "5c323f35-11b6-42c0-a044-b19f8df229e6", + "image_id": 200693, + "image_name": "10629.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2464.137, + 1110.155, + 545.8759999999997, + 45.57400000000007 + ], + "priority": 12, + "parents": [ + 4655 + ], + "children": [], + "area": 2735574.011235, + "iscrowd": 0, + "segmentation": [], + "text": "Period: July 2015 and June 2016" + }, + { + "id": 4663, + "strid": "069c053a-f8d8-4b62-9a6d-5eef4a25e6df", + "image_id": 200693, + "image_name": "10629.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2464.137, + 1194.214, + 563.0929999999998, + 239.01099999999997 + ], + "priority": 13, + "parents": [ + 4655 + ], + "children": [], + "area": 2942706.903318, + "iscrowd": 0, + "segmentation": [], + "text": "Site:\n\nMédecins sans Frontieres (MSF)\nmental health clinics in Serbia — a\nmain transit hub to European\ncountries." + }, + { + "id": 4664, + "strid": "28885f53-d92e-41f6-8a28-e8f80553afa4", + "image_id": 200693, + "image_name": "10629.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2462.112, + 1477.786, + 559.0419999999999, + 246.0999999999999 + ], + "priority": 14, + "parents": [ + 4655 + ], + "children": [], + "area": 3638474.644032, + "iscrowd": 0, + "segmentation": [], + "text": "Mental health clinics:\nConducted according to MSF\nguidelines by experienced\npsychologists\n\nSupported by cultural mediators." + }, + { + "id": 4671, + "strid": "7ee66098-5f71-4729-b9bb-894bab04d6ec", + "image_id": 200693, + "image_name": "10629.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2448.832, + 1752.56, + 671.835, + 617.6169999999997 + ], + "priority": 15, + "parents": [ + 4655 + ], + "children": [], + "area": 4291725.00992, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 4656, + "strid": "e7ff0bc6-d996-4de3-9d18-7465c3eb46f8", + "image_id": 200693, + "image_name": "10629.png", + "category_id": 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+ "iscrowd": 0, + "segmentation": [], + "text": "“| tried to cross the border with a group of migrants. There were five policemen on the Hungarian side who threatened us not to try to cross the border. We lit a fire and sat around\nabout 2km on the Serbian side.We thought we were safe. The policemen with five big dogs crossed to the Serbian side and chased us. They pushed us on the ground (including\nwomen) and kicked us with boots on our face and body. The dogs attacked and bit us too.The police then sprayed pepper spray in our eyes and threw our things into the fire. Some of\nthe women were thrown in the nearby water. One of the policemen was very big and strong and he kept throwing people around.The one that beat me did not stop until | stopped\nmoving and pretended to be dead.”\n\n“I suffered from severe injuries caused by a mine explosion many years ago in Afghanistan that left me physically disabled and with impaired sight. | was travelling with a young relative\nwho was an accompanying aid to me.We had been on the road for about five months. | got treated by MSF in Serbia and received a medical certificate of disability.! was among 10\npeople who crossed the Hungarian border and were caught by Hungarian police who beat us with their sticks, kicked us with boots also used pepper spray.We were also beaten by\ncivilians.”" + }, + { + "id": 132920, + "strid": "866549c2-64fc-4ebd-bb6b-e402b9ac7f0b", + "image_id": 205660, + "image_name": "15535.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 45.2, + 38.19, + 236.27000000000004, + 223.49 + ], + "priority": -1, + "parents": [], + "children": [ + 132895, + 132899, + 132896, + 132901, + 132897, + 132907, + 132903, + 132902, + 132898, + 132904, + 132905, + 132906, + 132900 + ], + "area": 1726.188, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 132895, + "strid": "aed99965-10c1-44e4-ba7c-eef8ec40d808", + "image_id": 205660, + "image_name": "15535.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 1389.29, + 29.875, + 1917.27, + 177.71 + ], + "priority": 1, + "parents": [ + 132920 + ], + "children": [], + "area": 41505.03875, + "iscrowd": 0, + "segmentation": [], + "text": "ResMarkerDB: a database of biomarkers of response to\nantibody therapy in breast and colorectal cancer" + }, + { + "id": 132896, + "strid": "69192a7e-5ad4-4728-a4f9-6a1988978d6b", + "image_id": 205660, + "image_name": "15535.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1455.095, + 234.781, + 1861.2450000000001, + 149.476 + ], + "priority": 2, + "parents": [ + 132920 + ], + "children": [], + "area": 341628.659195, + "iscrowd": 0, + "segmentation": [], + "text": "Judith Pérez-Granado, Janet Pifiero, Laura |. Furlong\n\nResearch Group on Integrative Biomedical Infor ics (GRIB), Institut Hospital del Mar d'Investigacions\n— a N(x lToLU xm ] lompeu Fabra (UPF), Barcelona, Spain" + }, + { + "id": 132897, + "strid": "1d2e49db-83fa-4508-988d-3a55a065eb31", + "image_id": 205660, + "image_name": "15535.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 91.581, + 458.933, + 246.757, + 41.57299999999998 + ], + "priority": 3, + "parents": [ + 132920 + ], + "children": [ + 132908 + ], + "area": 42029.543073, + "iscrowd": 0, + "segmentation": [], + "text": "INTRODUCTION" + }, + { + "id": 132908, + "strid": "e03316ba-46aa-4e53-aaab-dcbb85ca9cd6", + "image_id": 205660, + "image_name": "15535.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 94.899, + 525.683, + 3154.871, + 172.389 + ], + "priority": 4, + "parents": [ + 132897 + ], + "children": [], + "area": 49886.791017, + "iscrowd": 0, + "segmentation": [], + "text": "ResMarkerDB (http://resmarkerdb.org) is a centralized repository that gathers information on biomarkers of response to FDA-approved therapeutic monoclonal antibodies in breast and colorectal cancer (BC and CRC). These therapies effectiveness has\nimproved patients’ outcomes by individualizing their treatments according to their genetic background. However, primary or acquired resistance may occur. Several databases characterize biomarkers of drug response to help understand the underlying\nmolecular mechanisms. But this characterization is incomplete because cancer is a highly heterogeneous disease that challenges diagnosis and treatment. Besides, there is still information in the literature not collected by structured databases. Efforts to\n\nincorporate omics data reveal the importance of translational medicine and the need to integrate all these heterogeneous data." + }, + { + "id": 132898, + "strid": "67c75170-f254-4002-b107-b20f3da6107a", + "image_id": 205660, + "image_name": "15535.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 96.968, + 873.549, + 178.735, + 30.022000000000048 + ], + "priority": 5, + "parents": [ + 132920 + ], + "children": [ + 132909 + ], + "area": 84706.299432, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 132909, + "strid": "ce7536a2-c80e-478c-9396-dc4df912bb24", + "image_id": 205660, + "image_name": "15535.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 93.79, + 933.406, + 913.23, + 224.3019999999999 + ], + "priority": 6, + "parents": [ + 132898 + ], + "children": [], + "area": 87544.14874, + "iscrowd": 0, + "segmentation": [], + "text": "ResMarkerDB was developed as a user-friendly web interface to\nfacilitate exploration of our current knowledge of biomarkers of\nresponse to therapeutic monoclonal antibodies in BC and CRC. It allows\nexploration, visualization and prioritization of biomarkers in the context\n\nof response to therapy." + }, + { + "id": 132899, + "strid": "5db05cbc-b17a-47c7-9511-655e998366bd", + "image_id": 205660, + "image_name": "15535.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 96.453, + 1320.614, + 378.645, + 38.09500000000003 + ], + "priority": 7, + "parents": [ + 132920 + ], + "children": [ + 132910 + ], + "area": 127377.182142, + "iscrowd": 0, + "segmentation": [], + "text": "ResMarkerDB CONTENTS" + }, + { + "id": 132910, + "strid": "a180528e-ed6c-4d87-af5f-220ca3c37b37", + "image_id": 205660, + "image_name": "15535.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 90.877, + 1383.467, + 911.773, + 221.38900000000012 + ], + "priority": 8, + "parents": [ + 132899 + ], + "children": [], + "area": 125725.33055900001, + "iscrowd": 0, + "segmentation": [], + "text": "It contains biomarkers of response to FDA-approved therapeutic\nmonoclonal antibodies in BC and CRC. These biomarkers associated\nresponse is referenced to a source, level of evidence and in almost all\ncases to a statement supporting the evidence. The sources of these\n\nassociations are varied and different levels of evidence are considered." + }, + { + "id": 132900, + "strid": "ebd8a770-e1b9-4e4a-b29b-0233f20dec27", + "image_id": 205660, + "image_name": "15535.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1116.64, + 809.358, + 296.6969999999999, + 31.94100000000003 + ], + "priority": 9, + "parents": [ + 132920 + ], + "children": [ + 132914 + ], + "area": 903761.51712, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 132914, + "strid": "53e2c65a-471f-4a64-b619-a92e0a7a49ad", + "image_id": 205660, + "image_name": "15535.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1108.876, + 803.277, + 2153.179, + 875.183 + ], + "priority": 10, + "parents": [ + 132900 + ], + "children": [], + "area": 890734.5866520001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 132907, + "strid": "f5d44588-1229-4a86-b0fd-b93b9f8765b7", + "image_id": 205660, + "image_name": 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Researchers and practitioners\n\nHow is the information organized? In categories: biomarker, genes, drugs, tumor type, response, evidence level, source and\nstatement. We provide usage guidelines with explanations about the data contents, including the homogenization and\nstandardization process undergone, as well as the data statistics.\n\nWhich are the tumor types covered? Breast cancer and colorectal cancer, and some of their subtypes.\n\nWhich are the drugs covered? FDA-approved therapeutic monoclonal antibodies for BC and CRC, alone, and in combination\n\nwith other antineoplastic agents." + }, + { + "id": 132904, + "strid": "953bca55-90d3-487a-a0d6-39f7b7d39183", + "image_id": 205660, + "image_name": "15535.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1676.899, + 4057.958, + 170.64699999999993, + 36.00799999999981 + ], + "priority": 22, + "parents": [ + 132920 + ], + "children": [ + 132912 + ], + "area": 6804785.712242, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 132912, + "strid": "6ab29958-a2f2-4a6f-b128-e7b7d855fecb", + "image_id": 205660, + "image_name": "15535.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1674.99, + 4105.772, + 1576.171, + 223.88799999999992 + ], + "priority": 23, + "parents": [ + 132904 + ], + "children": [], + "area": 6877127.04228, + "iscrowd": 0, + "segmentation": [], + "text": "ResMarkerDB database currently features 266 biomarkers of diverse nature: 46 non-coding RNAs, = 180 gene variants, > 35\ncopy number alterations and > 35 alterations in gene expression, among others. These alterations span = 100 genes, and are\ninvolved in = 500 biomarker-drug-tumor associations. It also brings to light that there is still data in the literature that needs to\nbe properly annotated. ResMarkerDB aims to enhance translational research efforts in identifying existing actionable\nbiomarkers of drug response in cancer." + }, + { + "id": 132905, + "strid": "e5482a15-91fb-4cdf-9500-8618abdffb80", + "image_id": 205660, + "image_name": "15535.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 83.297, + 4453.649, + 309.422, + 31.131000000000313 + ], + "priority": 24, + "parents": [ + 132920 + ], + "children": [ + 132913 + ], + "area": 370975.600753, + "iscrowd": 0, + "segmentation": [], + "text": "ACKNOWLEDGMENTS" + }, + { + "id": 132913, + "strid": "66f46952-e571-4093-849b-6e4be021363e", + "image_id": 205660, + "image_name": "15535.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 82.846, + 4497.223, + 1600.218, + 141.2430000000004 + ], + "priority": 25, + "parents": [ + 132905 + ], + "children": [], + "area": 372576.936658, + "iscrowd": 0, + "segmentation": [], + "text": "FUNDING: We received support from ISCIII-FEDER (PIE15/00008, CP10/00524, CPII16/00026), the EU H2020 Programme 2014-2020 under grant agreements\nno. 634143 (MedBioinformatics) and no. 676559 (Elixir-Excelerate). The Research Programme on Biomedical Informatics (GRIB) is a member of the Spanish\nNational Bioinformatics Institute (INB), PRB2-ISCIII and is supported by grant PT13/0001/0023, of the PE I+D+i 2013-2016, funded by ISCIII and FEDER. The\nDCEXS is a “Unidad de Excelencia Maria de Maeztu”, funded by the MINECO (ref: MDM-2014-0370)." + }, + { + "id": 127745, + "strid": "512cfc43-04c8-45c7-80f1-85c2a5d9d82b", + "image_id": 205479, + "image_name": "15220.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 103.5, + 325.78, + 424.73, + 308.9 + ], + "priority": -1, + "parents": [], + "children": [ + 127727, + 127730, + 127725, + 127728, + 127729, + 127726, + 127724 + ], + "area": 33718.229999999996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 127724, + "strid": "b28eca1c-bd8b-46fd-8a34-ba9d991f826c", + "image_id": 205479, + "image_name": "15220.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 1150.12, + 56.758, + 2021.4499999999998, + 203.617 + ], + "priority": 1, + "parents": [ + 127745 + ], + "children": [], + "area": 65278.51096, + "iscrowd": 0, + "segmentation": [], + "text": "Reconstructing the phylogeny of Corynebacteriales\nwhile accounting for Horizontal Gene Transfer" + }, + { + "id": 127725, + "strid": "41b578b1-4799-416e-841d-b36837ddb853", + "image_id": 205479, + "image_name": "15220.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1119.291, + 337.624, + 2023.4380000000003, + 228.50599999999997 + ], + "priority": 2, + "parents": [ + 127745 + ], + "children": [], + "area": 377899.504584, + "iscrowd": 0, + "segmentation": [], + "text": "Nilson Da Rocha Coimbra’”, Aristoteles Goes”, Vasco Azevedo? and Aida Ouangraoua'\n' Department of Computer Science, University of Sherbrooke, Sherbrooke, Quebec, Canada\n\n2 Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil" + }, + { + "id": 127726, + "strid": "865a203a-c5b9-4de5-8473-0a3b6253e21d", + "image_id": 205479, + "image_name": "15220.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1466.249, + 657.77, + 385.635, + 77.90599999999995 + ], + "priority": 3, + "parents": [ + 127745 + ], + "children": [ + 127731 + ], + "area": 964454.60473, + "iscrowd": 0, + "segmentation": [], + "text": "Background" + }, + { + "id": 127731, + "strid": "da30f493-7387-4822-8d1c-29ec7058138a", + "image_id": 205479, + "image_name": "15220.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 48.317, + 782.29, + 3229.237, + 206.10699999999997 + ], + "priority": 4, + "parents": [ + 127726 + ], + "children": [], + "area": 37797.90593, + "iscrowd": 0, + "segmentation": [], + "text": "Horizontal Gene Transfer (HGT) is a common mechanism in bacteria that affects the genomic content of extant organisms. However, most traditional methods for\nbacterial phylogeny reconstruction assume only vertical inheritance in the evolution of homologous genes. Here, we present a new method for bacterial phylogeny\nreconstruction that accounts for the presence of genes acquired by HGT in genomes. A gene tree-based method was devised to identify and correct putative transferred\ngenes (PTG). The method is applied to the reconstruction of the phylogeny of the Order Corynebacteriales, the largest clade in the Phylum Actinobacteria." + }, + { + "id": 127727, + "strid": "21764826-f58d-48e4-a352-bf0f8fb779c5", + "image_id": 205479, + "image_name": "15220.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 630.614, + 1057.105, + 757.4200000000001, + 64.03800000000001 + ], + "priority": 5, + "parents": [ + 127745 + ], + "children": [ + 127733, + 127742, + 127743, + 127732, + 127744, + 127741, + 127738 + ], + "area": 666625.21247, + "iscrowd": 0, + "segmentation": [], + "text": "Materials and Methods" + }, + { + "id": 127732, + "strid": "f1ad1ce2-faf9-4bd1-b40b-41f17ade83a5", + "image_id": 205479, + "image_name": "15220.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 728.977, + 1202.759, + 530.666, + 46.843000000000075 + ], + "priority": 6, + "parents": [ + 127727 + ], + "children": [], + "area": 876783.6475429999, + "iscrowd": 0, + 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"image_name": "15220.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2024.658, + 3703.008, + 1168.984, + 150.9079999999999 + ], + "priority": 19, + "parents": [ + 127730 + ], + "children": [], + "area": 7497324.771263999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 127729, + "strid": "b1a82234-d876-4796-8a03-c73656ea290d", + "image_id": 205479, + "image_name": "15220.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 826.978, + 3562.787, + 355.9309999999999, + 64.08699999999999 + ], + "priority": 20, + "parents": [ + 127745 + ], + "children": [ + 127736 + ], + "area": 2946346.467686, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 127736, + "strid": "8ff829cd-0e88-4ebb-b2bb-dd106591ece5", + "image_id": 205479, + "image_name": "15220.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 82.781, + 3699.831, + 1848.608, + 162.5300000000002 + ], + "priority": 21, + "parents": [ + 127729 + ], + "children": [], + "area": 306275.71001100005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 38634, + "strid": "fdfcc83b-dd18-4952-8387-e3ffabdcdd3b", + "image_id": 202022, + "image_name": "118013.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 635.71, + 429.5, + 377.38, + 143.76 + ], + "priority": -1, + "parents": [], + "children": [ + 38610, + 38609, + 38605, + 38608, + 38607, + 38613, + 38611, + 38606, + 38612 + ], + "area": 273037.445, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 38605, + "strid": "d59cb1fb-24c7-406b-8459-2d3f187e6c2d", + "image_id": 202022, + "image_name": "118013.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 28.03, + 60.634, + 1813.32, + 313.863 + ], + "priority": 1, + "parents": [ + 38634 + ], + "children": [], + "area": 1699.57102, + "iscrowd": 0, + "segmentation": [], + "text": "Thermal adaptation of conformational\n\ndynamics in ribonuclease H" + }, + { + "id": 38606, + "strid": "54f4b22d-644a-49f8-8f8b-e3b539775695", + "image_id": 202022, + "image_name": "118013.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1952.535, + 57.854, + 1315.2499999999998, + 360.24 + ], + "priority": 2, + "parents": [ + 38634 + ], + "children": [], + "area": 112961.95989, + "iscrowd": 0, + "segmentation": [], + "text": "Kate A. Stafford, Paul Robustelli,\nArthur G. Palmer, III\n\nDepartment of Biochemistry and Molecular Biophysics\nColumbia University" + }, + { + "id": 38607, + "strid": "9d04fb44-aa74-4ff2-95af-29c1f01a0bc8", + "image_id": 202022, + "image_name": "118013.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 27.632, + 519.038, + 321.374, + 91.17100000000005 + ], + "priority": 3, + "parents": [ + 38634 + ], + "children": [ + 38614 + ], + "area": 14342.058016, + "iscrowd": 0, + "segmentation": [], + "text": "Abstract" + }, + { + "id": 38614, + "strid": "ecca57fc-f040-464d-b8ba-234f2ddf5276", + "image_id": 202022, + "image_name": "118013.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 33.13, + 628.906, + 1130.055, + 869.125 + ], + "priority": 4, + "parents": [ + 38607 + ], + "children": [], + "area": 20835.65578, + "iscrowd": 0, + "segmentation": [], + "text": "The relationship of protein conformational dynamics to enzymatic activity\nand thermostability is often difficult to elucidate. Because conformational\nchanges are often necessary for enzymes to carry out their catalytic\nfunction, and rigidification is a common mechanism of thermostabilization,\nadaptation to temperature extremes can require tradeoffs between stability\nand function. The study of homologous proteins with differing\nthermostabilities thus facilitates understanding of the functional aspects of\nconformational dynamics Ribonuclease HI (RNase H),a well-conserved\nendonuclease that hydrolyzes the RNA component of RNA:DNA duplexes,\nis a well-studied protein family in which structural information is available for\nclose homologs from organisms with a range of temperature tolerances.\nNuclear magnetic resonance (NMR) spectroscopy has previously identified\ndifferences in local flexibility between the homologs from the mesophilic\nbacterium Escherichia coli and the thermophilic bacterium Thermus\nthermophilus. In this work we integrate previous NMR observations of\nhandle-region dynamics in these two homologs into an interpretive\nframework derived from molecular dynamics (MD) simulations of all handle-\nregion-containing family members of known structure. These results\nillustrate the utility of combined MD-NMR studies in elucidating the effects\nof particular amino acid residues on molecular adaptation to features of the\nbulk environment." + }, + { + "id": 38608, + "strid": "9ad29d7c-c70d-4c04-9346-6846cb0ae75f", + "image_id": 202022, + "image_name": "118013.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 33.113, + 1592.474, + 440.333, + 88.30199999999991 + ], + "priority": 5, + "parents": [ + 38634 + ], + "children": [ + 38632, + 38619, + 38633, + 38618 + ], + "area": 52731.591561999994, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 38633, + "strid": "f375c557-863b-44a2-ab3c-abb76679b85c", + "image_id": 202022, + "image_name": "118013.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 95.975, + 1704.893, + 964.053, + 292.1700000000001 + ], + "priority": 6, + "parents": [ + 38608 + ], + "children": [], + "area": 163627.105675, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 38618, + "strid": "b6472aca-e40c-4512-a11e-d9470f88dc5d", + "image_id": 202022, + "image_name": "118013.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 33.99, + 2034.237, + 1109.947, + 164.04799999999977 + ], + "priority": 7, + "parents": [ + 38608 + ], + "children": [], + "area": 69143.71563, + "iscrowd": 0, + "segmentation": [], + "text": "Five RNase H homologs of known structure from organisms of varying\npreferred growth temperature were studied. The four bacterial proteins are\nlisted in order of preferred growth temperature, which largely correlates\nwith melting temperature." + }, + { + "id": 38632, + "strid": "18b6abee-bfad-4f96-9287-fedfd5049ae6", + "image_id": 202022, + "image_name": "118013.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 76.089, + 2221.343, + 1044.566, + 657.8620000000001 + ], + "priority": 8, + "parents": [ + 38608 + ], + "children": [], + "area": 169019.767527, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 38619, + "strid": "48240878-c625-4cb8-ac45-552f821385a8", + "image_id": 202022, + "image_name": "118013.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 32.426, + 2919.087, + 1114.412, + 332.72699999999986 + ], + "priority": 9, + "parents": [ + 38608 + ], + "children": [], + "area": 94654.31506200001, + "iscrowd": 0, + "segmentation": [], + "text": "Key features of RNase H structure and sequence. (A)\nStructural superposition of and ttRNH. Key residues in the handle\nregion and active site (arrow) are shown as sticks. K95 and the inserted\nglycine are known to affect thermostability. (B) The structure with\nthe substrate-bound complex of hsRNH, showing the position of the handle\nregion interacting with the == =~—_— oof the substrate. (C) Sequence\nalignment of helices B, C, and the handle loop. Significant sites are\nhighlighted in red." + }, + { + "id": 38611, + "strid": "730fc2d5-fb04-4a7b-87a1-4f1d7ff08f42", + "image_id": 202022, + "image_name": "118013.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 38.028, + 3356.894, + 333.147, + 88.52799999999979 + ], + "priority": 10, + "parents": [ + 38634 + ], + "children": [ + 38620 + ], + "area": 127655.965032, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 38620, + "strid": "cd223e9d-9f1a-4af0-b451-7a526117bf2e", + "image_id": 202022, + "image_name": "118013.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 33.351, + 3472.335, + 1123.3269999999998, + 518.2150000000001 + ], + "priority": 11, + "parents": [ + 38611 + ], + "children": [], + "area": 115805.844585, + "iscrowd": 0, + "segmentation": [], + "text": "Simulations were performed using Desmond Academic release 3 or source\nrelease 2.4.2.1 [1]. Proteins were described with the Amber99SB force field\n[2] , solvated with TIP3P water in a cubic box with a 0A buffer region, and\nneutralized with Cl” ions. Electrostatics were calculated with the PME\nmethod. All simulations used a 2.5fs inner timestep ona |-/-3 RESPA cycle\nand were performed in the NVT ensemble using a Nosé-Hoover\nthermostat after equilibration to constant box volume in NPT.\n\nPDB structures were used to initiate trajectories for wild-type simulations\nrun for 100ns each. All structures were protonated in accordance with H++\n[3] pKa predictions to replicate the pH of 5.5 used in previous NMR\nexperiments. Chemical shift predictions were performed using Sparta+ [4]\nas described [5]." + }, + { + "id": 38613, + "strid": "4203d4a8-f46e-4eef-b632-51eb0df1bc9e", + "image_id": 202022, + "image_name": "118013.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 42.22, + 4073.936, + 846.352, + 89.03500000000031 + ], + "priority": 12, + "parents": [ + 38634 + ], + "children": [ + 38621, + 38625 + ], + "area": 172001.57792, + "iscrowd": 0, + "segmentation": [], + "text": "References and Thanks" + }, + { + "id": 38625, + "strid": "c03420ba-3f69-4910-ae31-bb71e0e89145", + "image_id": 202022, + "image_name": "118013.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 52.163, + 4177.735, + 1064.962, + 237.10699999999997 + ], + "priority": 13, + "parents": [ + 38613 + ], + "children": [], + "area": 217923.19080499996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 38621, + "strid": "4a7b5cc6-b528-4d6a-9f60-81ac51c2d1d0", + "image_id": 202022, + "image_name": "118013.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 38.744, + 4429.603, + 1096.808, + 197.71200000000044 + ], + "priority": 14, + "parents": [ + 38613 + ], + "children": [], + "area": 171620.538632, + "iscrowd": 0, + "segmentation": [], + "text": "A paper describing this work has recently been accepted to PLloS Computational Biology.\n\nThis research was funded by an NSF graduate research fellowship (K.A.S.),an NSF postdoctoral research\nfellowship in Biology (grant 1002684) (PR.), and NIH grant GM50291 (A.G.P).We thank the Center for\nComputational Biology and Bioinformatics (C2B2) for computational resources.We thank Jae-hyun Cho and\nNikola Trbovic for helpful discussions. Travel funding to ISMB/ECCB 2013 was generously provided by the\nNational Science Foundation." + }, + { + "id": 38609, + "strid": "e5bd5aea-fb94-4add-9601-c88a2134bd68", + "image_id": 202022, + "image_name": "118013.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1259.027, + 516.662, + 1860.107, + 206.71900000000005 + ], + "priority": 15, + "parents": [ + 38634 + ], + "children": [ + 38629, + 38617, + 38615, + 38616, + 38631, + 38630 + ], + "area": 650491.407874, + "iscrowd": 0, + "segmentation": [], + "text": "MD simulations reveal a conserved dynamic mode\nvalidated by comparison to NMR chemical shifts" + }, + { + "id": 38631, + "strid": "13516601-6434-467a-ac20-2f8475e17670", + "image_id": 202022, + "image_name": "118013.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1264.049, + 747.194, + 999.9580000000001, + 616.72 + ], + "priority": 16, + "parents": [ + 38609 + ], + "children": [], + "area": 944489.828506, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 38615, + "strid": "988f91ed-68b2-4389-b571-f35d1b876b5e", + "image_id": 202022, + "image_name": "118013.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2273.684, + 754.139, + 1003.8289999999997, + 584.59 + ], + "priority": 17, + "parents": [ + 38609 + ], + "children": [], + "area": 1714673.7780760003, + "iscrowd": 0, + "segmentation": [], + "text": "Dynamics of the RNase H handle region as a\nfunction of temperature. (A) Key residues\nmodulating handle region dynamics and their identities in\neach homolog (soRNH, , ctRNH, ttRNH, hsRNH).\n(B) Representative conformations from ecRNH of the\n\nand closed states, illustrating a reaction coordinate of\nthe Cartesian distance between the C, atoms of the\nresidues indicated. (C) Temperature dependence of\nsoRNH (left), ecRNH (middle), and ttRNH (right) handle-\nregion dynamics illustrating the relative populations of the\nclosed and open states at 273K, 300K, and 340K. Crystal\nstructure measurements are shown in green." + }, + { + "id": 38616, + "strid": "f369ebe3-a4f3-4af5-a95c-cf308a059696", + "image_id": 202022, + "image_name": "118013.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1235.642, + 1444.836, + 496.41100000000006, + 769.4179999999999 + ], + "priority": 18, + "parents": [ + 38609 + ], + "children": [], + "area": 1785300.044712, + "iscrowd": 0, + "segmentation": [], + "text": "Dynamically averaged\nchemical shift\npredictions. (A)\nExperimental and\n\nsecondary chemical shifts for\nCa and N nuclei. Helices B,\nC, and the handle region are\nshown in green. (B)\nExperimental and predicted\nsecondary chemical shifts for\nttRNH. Values are plotted as\nsecondary chemical shifts\n(deviation from random-coil\nvalue for each residue);\nRMSDs are calculated using\nthe absolute shifts." + }, + { + "id": 38630, + "strid": "4f18936a-529b-431d-8afa-6278399caa4a", + "image_id": 202022, + "image_name": "118013.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1753.735, + 1434.062, + 576.307, + 780.1459999999997 + ], + "priority": 19, + "parents": [ + 38609 + ], + "children": [], + "area": 2514964.7215699996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 38629, + "strid": "87c18ad7-b7b4-401b-b1e8-52767ce86686", + "image_id": 202022, + "image_name": "118013.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2380.619, + 1369.793, + 837.982, + 539.9449999999999 + ], + "priority": 20, + "parents": [ + 38609 + ], + "children": [], + "area": 3260955.241867, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 38617, + "strid": "b82ba7ac-8fbb-43c3-bf40-8d25cd09300f", + "image_id": 202022, + "image_name": "118013.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2359.787, + 1927.097, + 914.4780000000001, + 288.54600000000005 + ], + "priority": 21, + "parents": [ + 38609 + ], + "children": [], + "area": 4547538.448338999, + "iscrowd": 0, + "segmentation": [], + "text": "Free-energy landscapes. (A) The free-energy\ndiagram under the assumption that ecRNH and\nttRNH share a major state that is incompetent for\nsubstrate binding [5]. (B) Simulations suggest instead\nthat the closed minor state of ecRNH is equivalent to\nthe major state of ttRNH and vice versa." + }, + { + "id": 38610, + "strid": "71af9fbd-1e2d-41d3-95f2-c2e96c6294fb", + "image_id": 202022, + "image_name": "118013.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1220.774, + 2301.04, + 2002.522, + 111.95299999999997 + ], + "priority": 22, + "parents": [ + 38634 + ], + "children": [ + 38628, + 38624 + ], + "area": 2809049.80496, + "iscrowd": 0, + "segmentation": [], + "text": "Relative populations can be tuned by mutation in silico" + }, + { + "id": 38628, + "strid": "01e56412-41f0-4acc-94c8-fabca748ccb4", + "image_id": 202022, + "image_name": "118013.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1227.177, + 2448.737, + 1153.452, + 817.636 + ], + "priority": 23, + "parents": [ + 38610 + ], + "children": [], + "area": 3005033.725449, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 38624, + "strid": "0ac5cd06-b0b0-4563-9c28-b084a65ab1f8", + "image_id": 202022, + "image_name": "118013.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2419.44, + 2473.61, + 835.7829999999999, + 726.2660000000001 + ], + "priority": 24, + "parents": [ + 38610 + ], + "children": [], + "area": 5984750.9784, + "iscrowd": 0, + "segmentation": [], + "text": "Coupling of handle-region dynamics to\nV98 and VIOI. (A) Correlation between the\nhandle distance metric and the C& chemical shift\nof V98 in ecCRNH.The most common V98\nrotamer giving rise to the corresponding\nchemical shift value is indicated. (B) Effects of\nV98 mutants on ecRNH and ttRNH. In ecRNH,\nthe closed state is now favored. (C) Correlation\nbetween the handle distance metric and the N\nchemical shift of VIOI in ecRNH. (D) Coupled\neffects of mutations at positions 95 and 101 in\nttRNH and ttRNH dG8Q0, in which the inserted\nglycine is removed. Only ttRNH dG80 G95K/\nRIOIV shows a population of the open state\nsignificantly enriched compared to wild-type." + }, + { + "id": 38612, + "strid": "ef009bdf-bb82-4604-9114-e53c99cb47f7", + "image_id": 202022, + "image_name": "118013.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1211.4, + 3372.033, + 1929.563, + 216.26499999999987 + ], + "priority": 25, + "parents": [ + 38634 + ], + "children": [ + 38626, + 38627, + 38622, + 38623 + ], + "area": 4084880.7762, + "iscrowd": 0, + "segmentation": [], + "text": "An unexpected alternative mode is identified by MD\ndespite high sequence conservation" + }, + { + "id": 38626, + "strid": "895b525d-ab05-4d0f-a50a-917d32d865ce", + "image_id": 202022, + "image_name": "118013.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1234.189, + 3637.269, + 1108.959, + 359.9340000000002 + ], + "priority": 26, + "parents": [ + 38612 + ], + "children": [], + "area": 4489077.389841, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 38627, + "strid": "212ec00c-4f7e-4d6e-877c-971e1b3f7607", + "image_id": 202022, + "image_name": "118013.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1246.603, + 4020.716, + 1032.5900000000001, + 613.5830000000001 + ], + "priority": 27, + "parents": [ + 38612 + ], + "children": [], + "area": 5012236.627748, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 38623, + "strid": "780d1c8a-210b-48a4-8318-0e997a0ab5b9", + "image_id": 202022, + "image_name": "118013.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2353.293, + 3665.11, + 910.8879999999999, + 486.0880000000002 + ], + "priority": 28, + "parents": [ + 38612 + ], + "children": [], + "area": 8625077.70723, + "iscrowd": 0, + "segmentation": [], + "text": "Dynamics of the handle region in the\npresence of Asn at position 88. (A)\nTemperature-dependent populations for the two\nnatively Asn-containing proteins—ctRNH and hsRNH\n— illustrating the presence of a single conformational\ndistribution centered around the crystal-structure\nposition (green). (B) The presence of Asn at this site\npermits the formation of two highly stable hydrogen\nbonds to the backbone of residue 91 when Asn\noccupies the gauche- rotamer." + }, + { + "id": 38622, + "strid": "d5c2712d-6984-4921-ad47-b5e487728246", + "image_id": 202022, + "image_name": "118013.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2351.211, + 4274.616, + 898.4929999999999, + 291.97099999999955 + ], + "priority": 29, + "parents": [ + 38612 + ], + "children": [], + "area": 10050524.159976, + "iscrowd": 0, + "segmentation": [], + "text": "Handle-region behavior for reciprocal\nmutants at position 88. The top row shows\nwild-type proteins and the bottom shows each\nprotein’s corresponding mutant simulated at 300K.\nBlue distributions reflect a positively charged residue\nat this site (Arg or Lys) and orange indicates Asn." + }, + { + "id": 145972, + "strid": "65aa7721-899c-4df4-b396-92d95d6fdb29", + "image_id": 206165, + "image_name": "18637.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 33.24, + 29.52, + 172.44, + 154.29999999999998 + ], + "priority": -1, + "parents": [], + "children": [ + 145953, + 145959, + 145955, + 145961, + 145956, + 145958, + 145960, + 145954, + 145957 + ], + "area": 981.2448, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 145953, + "strid": "86aed92b-d18d-45ff-88d2-275f50af7f6e", + "image_id": 206165, + "image_name": "18637.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 213.668, + 182.136, + 1372.2019999999998, + 55.614000000000004 + ], + "priority": 1, + "parents": [ + 145972 + ], + "children": [], + "area": 38916.634848, + "iscrowd": 0, + "segmentation": [], + "text": "ProteinBERT: A protein sequence & function deep-learning model" + }, + { + "id": 145954, + "strid": "493150b1-e699-4e9e-836d-a42b00c5d6b4", + "image_id": 206165, + "image_name": "18637.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 358.947, + 280.88, + 1085.0499999999997, + 38.59000000000003 + ], + "priority": 2, + "parents": [ + 145972 + ], + "children": [], + "area": 100821.03336, + "iscrowd": 0, + "segmentation": [], + "text": "Dan Ofer, Nadav Brandes and Michal Linial, The Hebrew University of Jerusalem, Israel" + }, + { + "id": 145955, + "strid": "76da335d-1433-4677-953a-8aae67f0673b", + "image_id": 206165, + "image_name": "18637.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 268.796, + 378.489, + 415.892, + 35.185 + ], + "priority": 3, + "parents": [ + 145972 + ], + "children": [ + 145962 + ], + "area": 101736.329244, + "iscrowd": 0, + "segmentation": [], + "text": "Tl;dr — A protein language model" + }, + { + "id": 145962, + "strid": "dc82ddd3-9c4c-4c47-8e24-c25a998b4304", + "image_id": 206165, + "image_name": "18637.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 94.249, + 482.66, + 749.619, + 444.771 + ], + "priority": 4, + "parents": [ + 145955 + ], + "children": [], + "area": 45490.22234, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 145957, + "strid": "24825818-b9f0-4b4b-8735-782c52cc4b4a", + "image_id": 206165, + "image_name": "18637.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 321.431, + 1103.958, + 301.47599999999994, + 34.194999999999936 + ], + "priority": 5, + "parents": [ + 145972 + ], + "children": [ + 145964 + ], + "area": 354846.323898, + "iscrowd": 0, + "segmentation": [], + "text": "ProteinBERT at a glance" + }, + { + "id": 145964, + "strid": "665fbbc1-f4f5-4d88-8b4e-fdc51c1a62f3", + "image_id": 206165, + "image_name": "18637.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 88.363, + 1252.857, + 689.9659999999999, + 450.62799999999993 + ], + "priority": 6, + "parents": [ + 145957 + ], + "children": [], + "area": 110706.203091, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 145959, + "strid": "4d9b1ffd-72d0-4ac4-bc58-7e8c9d8779a6", + "image_id": 206165, + "image_name": "18637.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 322.632, + 1871.331, + 243.19099999999997, + 29.14300000000003 + ], + "priority": 7, + "parents": [ + 145972 + ], + "children": [ + 145968, + 145967 + ], + "area": 603751.263192, + "iscrowd": 0, + "segmentation": [], + "text": "Model architecture" + }, + { + "id": 145967, + "strid": "a48111b0-2ffd-44c8-a81d-8856b06310a0", + "image_id": 206165, + "image_name": "18637.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 184.31, + 1959.792, + 537.383, + 630.3530000000001 + ], + "priority": 8, + "parents": [ + 145959 + ], + "children": [], + "area": 361209.26352, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 145968, + "strid": "e3b80026-bbd8-4eaa-a24f-f6c6ea526f09", + "image_id": 206165, + "image_name": "18637.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 88.276, + 2640.205, + 738.647, + 234.97699999999986 + ], + "priority": 9, + "parents": [ + 145959 + ], + "children": [], + "area": 233066.73658, + "iscrowd": 0, + "segmentation": [], + "text": "Unlike standard Transformers, ProteinBERT supports both local\n(sequential) and global data. The model has 6 transformer blocks\nmanipulating local (left side) and global (right side)\nrepresentations using fully-connected and convolutional layers,\nand residual connections. A global attention layer “connects” the\nlocal and global components, with linear complexity (as opposed\nto quadratic self-attention)." + }, + { + "id": 145956, + "strid": "7f52f4d9-e268-41dc-9ac0-a5df134b185e", + "image_id": 206165, + "image_name": "18637.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1210.86, + 386.55, + 210.20499999999993, + 32.428 + ], + "priority": 10, + "parents": [ + 145972 + ], + "children": [ + 145963 + ], + "area": 468057.93299999996, + "iscrowd": 0, + "segmentation": [], + "text": "Pretraining Stats" + }, + { + "id": 145963, + "strid": "18459ec4-b0b9-4260-b04b-585b8359ad69", + "image_id": 206165, + "image_name": "18637.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 982.599, + 498.782, + 682.0470000000001, + 298.32699999999994 + ], + "priority": 11, + "parents": [ + 145956 + ], + "children": [], + "area": 490102.694418, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 145958, + "strid": "79344083-26db-48de-b924-d5158cf01d27", + "image_id": 206165, + "image_name": "18637.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1088.776, + 834.376, + 489.366, + 33.202999999999975 + ], + "priority": 12, + "parents": [ + 145972 + ], + "children": [ + 145965, + 145971 + ], + "area": 908448.563776, + "iscrowd": 0, + "segmentation": [], + "text": "Pretraining impact on benchmark tasks" + }, + { + "id": 145965, + "strid": "7df8cce1-4ed3-4066-9f55-341bf7fe6d43", + "image_id": 206165, + "image_name": "18637.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 972.341, + 930.659, + 673.2110000000001, + 477.3670000000001 + ], + "priority": 13, + "parents": [ + 145958 + ], + "children": [], + "area": 904917.902719, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 145971, + "strid": "09440002-e136-46d9-805d-e4e1fca056aa", + "image_id": 206165, + "image_name": "18637.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 972.95, + 1424.562, + 609.4260000000002, + 60.212999999999965 + ], + "priority": 14, + "parents": [ + 145958 + ], + "children": [], + "area": 1386027.5979, + "iscrowd": 0, + "segmentation": [], + "text": "Performance of fine-tuned ProteinBERT models over TAPE\nbenchmarks test set as a function of pretraining amount" + }, + { + "id": 145960, + "strid": "c0b5fea8-e9b1-4a99-9710-233a2ad674de", + "image_id": 206165, + "image_name": "18637.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1153.398, + 1541.816, + 355.1009999999999, + 28.979000000000042 + ], + "priority": 15, + "parents": [ + 145972 + ], + "children": [ + 145969, + 145966 + ], + "area": 1778327.4907679998, + "iscrowd": 0, + "segmentation": [], + "text": "Understanding global attention" + }, + { + "id": 145966, + "strid": "2346951c-cec0-420a-bc2d-ee8255dc03f8", + "image_id": 206165, + "image_name": "18637.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 991.562, + 1630.843, + 649.832, + 521.403 + ], + "priority": 16, + "parents": [ + 145960 + ], + "children": [], + "area": 1617081.946766, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 145969, + "strid": "3a99988c-1715-4adb-939b-9801c8f30f94", + "image_id": 206165, + "image_name": "18637.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 988.342, + 2176.817, + 694.4730000000001, + 186.08500000000004 + ], + "priority": 17, + "parents": [ + 145960 + ], + "children": [], + "area": 2151439.667414, + "iscrowd": 0, + "segmentation": [], + "text": "The heatmap of global attention values at each residue by each of\nthe model's 24 attention heads. The bar plot shows the total\nattention at each residue by summing the attention values across\nall attention heads. The right panel shows the difference in\nattention values after fine-tuning ProteinBERT for signal peptide\nprediction, over GAMMACAL2" + }, + { + "id": 145961, + "strid": "1155b042-9278-4144-b0a2-e54f7e56670a", + "image_id": 206165, + "image_name": "18637.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1226.01, + 2424.176, + 156.37400000000002, + 33.01200000000017 + ], + "priority": 18, + "parents": [ + 145972 + ], + "children": [ + 145970 + ], + "area": 2972064.0177599997, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 145970, + "strid": "a67ada0b-38a2-4e04-8b9f-345a96a02bf6", + "image_id": 206165, + "image_name": "18637.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 982.212, + 2528.358, + 707.759, + 210.9920000000002 + ], + "priority": 19, + "parents": [ + 145961 + ], + "children": [], + "area": 2483383.567896, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190441, + "strid": "6113a081-eedb-4764-b987-edcce8a7622d", + "image_id": 207932, + "image_name": "9139.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 48.43, + 35.4, + 220.08999999999997, + 162.17 + ], + "priority": -1, + "parents": [], + "children": [ + 190421, + 190419, + 190422, + 190423, + 190420, + 190442, + 190424 + ], + "area": 1714.422, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190419, + "strid": "f4d98060-f362-432d-97f5-4080434759fd", + "image_id": 207932, + "image_name": "9139.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 169.816, + 218.171, + 3113.188, + 286.157 + ], + "priority": 1, + "parents": [ + 190441 + ], + "children": [], + "area": 37048.926536, + "iscrowd": 0, + "segmentation": [], + "text": "RGAugury: A pipeline for genome-wide prediction of resistance\ngene analogs (RGAs) in plants" + }, + { + "id": 190442, + "strid": "5eea5819-84be-411e-825a-67443ce4c82b", + "image_id": 207932, + "image_name": "9139.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 187.436, + 548.731, + 1495.979, + 199.11199999999997 + ], + "priority": 2, + "parents": [ + 190441 + ], + "children": [], + "area": 102851.94371600001, + "iscrowd": 0, + "segmentation": [], + "text": "Pingchuan Li’, Sylvie Cloutier?, Frank M. You\"\n\n‘Morden Research and Development Centre, Agriculture and Agri-Food Canada, Morden, Canada;\n2Ottawa Research and Development Centre, Agriculture and Agri-Food Canada, Ottawa, Canada." + }, + { + "id": 190420, + "strid": "7186e00f-d195-490c-b3d6-5e3504e89e2d", + "image_id": 207932, + "image_name": "9139.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 116.291, + 806.157, + 454.0040000000001, + 73.51800000000003 + ], + "priority": 3, + "parents": [ + 190441 + ], + "children": [ + 190425 + ], + "area": 93748.803687, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 190425, + "strid": "0482b579-1c85-4f21-8576-770df84f14da", + "image_id": 207932, + "image_name": "9139.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 112.014, + 913.965, + 1582.931, + 555.4420000000001 + ], + "priority": 4, + "parents": [ + 190420 + ], + "children": [], + "area": 102376.87551, + "iscrowd": 0, + "segmentation": [], + "text": "Resistance gene analogs (RGAs) are a large class of potential R-genes that have\nconserved domain and motif configurations. Interaction between plant and pathogen\nis determined by the presence of R-genes that enable plants to recognize different\nsource of invading pathogens and activate corresponding defenses (Staskawicz et\nal., 1995). Here, we developed an RGA identification pipeline, named RGAugury,\nwhich can systematically analyze whole genome coding genes and output major\ncategories of RGAs, including NBS encoding, membrane associated receptor like\nprotein (RLP), receptor like protein kinase (RLK), and those conferring\ntransmembrane and coiled-coil domain (TMCC) architecture. RGAugury is a useful\nbioinformatics tool for RGA identification, gene fine mapping and cloning, and\ncomparative genome analysis." + }, + { + "id": 190421, + "strid": "20aefc32-3ed9-4117-a037-be85490d2e6e", + "image_id": 207932, + "image_name": "9139.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 117.581, + 1534.885, + 706.801, + 73.51800000000003 + ], + "priority": 5, + "parents": [ + 190441 + ], + "children": [ + 190428 + ], + "area": 180473.313185, + "iscrowd": 0, + "segmentation": [], + "text": "Material & Methods" + }, + { + "id": 190428, + "strid": "d65ae250-cdf1-49a0-b605-514cad3d0d36", + "image_id": 207932, + "image_name": "9139.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 124.593, + 1657.906, + 1568.583, + 404.55200000000013 + ], + "priority": 6, + "parents": [ + 190421 + ], + "children": [], + "area": 206563.482258, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190422, + "strid": "7576477b-b019-43de-8665-375c09d6f0bf", + "image_id": 207932, + "image_name": "9139.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 120.161, + 2108.838, + 868.0239999999999, + 70.9380000000001 + ], + "priority": 7, + "parents": [ + 190441 + ], + "children": [ + 190429, + 190438, + 190435, + 190436, + 190432, + 190437, + 190430 + ], + "area": 253400.08291800003, + "iscrowd": 0, + "segmentation": [], + "text": "Results and Discussion" + }, + { + "id": 190429, + "strid": "d892e90a-115d-4bb4-9a02-0843618a5b44", + "image_id": 207932, + "image_name": "9139.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 117.281, + 2205.1, + 1585.244, + 1492.3470000000002 + ], + "priority": 8, + "parents": [ + 190422 + ], + "children": [], + "area": 258616.3331, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190430, + "strid": "5cc8af8f-b9a7-42d5-a9aa-6149796afe41", + "image_id": 207932, + "image_name": "9139.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 132.02, + 3709.556, + 1562.555, + 504.5430000000001 + ], + "priority": 9, + "parents": [ + 190422 + ], + "children": [ + 190431 + ], + "area": 489735.58312, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190431, + "strid": "1c54c903-337e-46b0-992a-b978d639e8fc", + "image_id": 207932, + "image_name": "9139.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 133.548, + 4227.86, + 1463.176, + 168.18099999999959 + ], + "priority": 10, + "parents": [ + 190430 + ], + "children": [], + "area": 564622.24728, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 1 Workflow of RGAugury pipeline. This pipeline was designed to use protein sequences to\nidentify resistance relevant conserved domains and motifs by integrating results from several third-\nparty tools, such as InterProScan, BLAST and HMMER3. The annotated RGA candidates of major\nRGA types are outputed." + }, + { + "id": 190437, + "strid": "97515e9c-8ee9-45a5-b43d-b3e2de238ab5", + "image_id": 207932, + "image_name": "9139.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1854.519, + 596.2, + 1509.5090000000002, + 1430.099 + ], + "priority": 11, + "parents": [ + 190422 + ], + "children": [ + 190439 + ], + "area": 1105664.2278, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190439, + "strid": "22787084-058e-4224-a671-8c2007541b5a", + "image_id": 207932, + "image_name": "9139.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1876.393, + 534.545, + 1141.4769999999999, + 34.73599999999999 + ], + "priority": 12, + "parents": [ + 190437 + ], + "children": [], + "area": 1003016.4961849999, + "iscrowd": 0, + "segmentation": [], + "text": "Summary of RGA identification for 50 sequenced plant genomes" + }, + { + "id": 190438, + "strid": "790e8b11-f485-4671-adaf-c2ead8d4831c", + "image_id": 207932, + "image_name": "9139.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1843.13, + 2104.774, + 778.9830000000002, + 400.1460000000002 + ], + "priority": 13, + "parents": [ + 190422 + ], + "children": [ + 190440 + ], + "area": 3879372.10262, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190440, + "strid": "4f3a6012-c64d-44f9-8795-aea18e7f2d5f", + "image_id": 207932, + "image_name": "9139.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1830.861, + 2050.416, + 784.2369999999999, + 33.71799999999985 + ], + "priority": 14, + "parents": [ + 190438 + ], + "children": [], + "area": 3754026.6881760005, + "iscrowd": 0, + "segmentation": [], + "text": "Evaluation of RGAugury using A. thaliana" + }, + { + "id": 190432, + "strid": "9b83d8c9-6010-4c69-a2c4-43e46f86f07e", + "image_id": 207932, + "image_name": "9139.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2708.248, + 2056.795, + 666.6089999999999, + 380.701 + ], + "priority": 15, + "parents": [ + 190422 + ], + "children": [ + 190433 + ], + "area": 5570310.945160001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190433, + "strid": "4d4da4ed-d170-4892-af98-c4e6410817c1", + "image_id": 207932, + "image_name": "9139.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2720.479, + 2461.959, + 695.6579999999999, + 243.09799999999996 + ], + "priority": 16, + "parents": [ + 190432 + ], + "children": [], + "area": 6697707.758360999, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 2 Performance of RGAugury. Forty-\neight sequenced plant genomes with different\nnumber of protein coding genes were tested\nfor time consumption on a server embedded\nwith 40 CPU threads. Two species were not\nincluded because of outliers." + }, + { + "id": 190435, + "strid": "26f6e4bc-f9c9-47c4-ab6c-9e52d4107c81", + "image_id": 207932, + "image_name": "9139.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1830.649, + 2570.512, + 874.5419999999999, + 1186.4410000000003 + ], + "priority": 17, + "parents": [ + 190422 + ], + "children": [ + 190434 + ], + "area": 4705705.222288, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190434, + "strid": "9f1ef5b4-a340-4e77-96dd-e77686c0c351", + "image_id": 207932, + "image_name": "9139.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2720.479, + 2741.751, + 697.1869999999999, + 365.4119999999998 + ], + "priority": 18, + "parents": [ + 190435 + ], + "children": [], + "area": 7458876.018729, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 3 Web user interface of RGAugury. All\nparameters required in the command line\nversion are specified directly from a web\npage. If a gff3 file is available, a genome-wide\nRGA distribution figure can be plotted\nafterwards by CViT. Other convenient options\nsuch as email notification, CPU number\nrequest, and InterProScan database selection\nwere also implemented." + }, + { + "id": 190436, + "strid": "1e502c3d-d331-4202-9996-d8a448bef3d5", + "image_id": 207932, + "image_name": "9139.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2569.117, + 3128.567, + 865.3679999999999, + 717.0630000000001 + ], + "priority": 19, + "parents": [ + 190422 + ], + "children": [], + "area": 8037654.6653390005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 190423, + "strid": "39e9b8ab-e2b7-4aa8-a3b4-5db59d6e1182", + "image_id": 207932, + "image_name": "9139.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1842.614, + 3872.063, + 326.67599999999993, + 72.07200000000012 + ], + "priority": 20, + "parents": [ + 190441 + ], + "children": [ + 190426 + ], + "area": 7134717.492682001, + "iscrowd": 0, + "segmentation": [], + "text": "ete aI ela" + }, + { + "id": 190426, + "strid": "5d272592-d566-4c9e-b7b8-2c94029b997e", + "image_id": 207932, + "image_name": "9139.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1831.84, + 3975.977, + 1576.6380000000001, + 154.20200000000023 + ], + "priority": 21, + "parents": [ + 190423 + ], + "children": [], + "area": 7283353.707679999, + "iscrowd": 0, + "segmentation": [], + "text": "Identification of several other categories of potential resistance genes, such as PPR\nand peroxidase is not included in the current version of RGAugury. Their\nidentification will be integrated in future when their resistance mechanisms are clear." + }, + { + "id": 190424, + "strid": "1386074a-47e4-43c5-8e31-4f7956c75f6e", + "image_id": 207932, + "image_name": "9139.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1852.015, + 4175.237, + 723.858, + 82.2569999999996 + ], + "priority": 22, + "parents": [ + 190441 + ], + "children": [ + 190427 + ], + "area": 7732601.552555, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements" + }, + { + "id": 190427, + "strid": "f94abe5e-458f-47bb-897a-c928a5106025", + "image_id": 207932, + "image_name": "9139.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1830.266, + 4276.514, + 1575.0639999999999, + 111.71799999999985 + ], + "priority": 23, + "parents": [ + 190424 + ], + "children": [], + "area": 7827158.172724, + "iscrowd": 0, + "segmentation": [], + "text": "This research was supported by the GRDI program (project No. J-O00006) funded by\nAgriculture and Agri-Food Canada." + }, + { + "id": 129425, + "strid": "1a2b2849-6172-4c11-bdba-47e36ad67cc1", + "image_id": 205532, + "image_name": "15290.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 302.03, + 155.33, + 197.63000000000005, + 187.22 + ], + "priority": -1, + "parents": [], + "children": [ + 129403, + 129412, + 129402, + 129401, + 129405, + 129404, + 129400 + ], + "area": 46914.3199, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 129400, + "strid": "9c47f251-78b7-4b77-8768-f33106833669", + "image_id": 205532, + "image_name": "15290.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 687.889, + 33.829, + 2005.8429999999998, + 228.35199999999998 + ], + "priority": 1, + "parents": [ + 129425 + ], + "children": [], + "area": 23270.596981000002, + "iscrowd": 0, + "segmentation": [], + "text": "GeneDMRs: an R package for Gene-based\nDifferentially Methylated Regions analysis" + }, + { + "id": 129401, + "strid": "1aa782f2-cef7-48f0-b98f-ede7ea116042", + "image_id": 205532, + "image_name": "15290.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 876.895, + 299.694, + 1635.5660000000003, + 131.692 + ], + "priority": 2, + "parents": [ + 129425 + ], + "children": [], + "area": 262800.17013, + "iscrowd": 0, + "segmentation": [], + "text": "Xiao Wang! , Dan Hao’, Haja N. Kadarmideen'\n‘Department of Applied Mathematics and Computer Science, DTU, Kongens Lyngby, Denmark" + }, + { + "id": 129402, + "strid": "b5189c0b-d519-45e8-99a9-78297036f714", + "image_id": 205532, + "image_name": "15290.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 71.023, + 523.813, + 393.65199999999993, + 73.40300000000002 + ], + "priority": 3, + "parents": [ + 129425 + ], + "children": [ + 129406 + ], + "area": 37202.770699, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 129406, + "strid": "9f847740-f880-46a1-980a-b5a49cdcbed8", + "image_id": 205532, + "image_name": "15290.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 56.452, + 613.147, + 1565.772, + 775.0089999999999 + ], + "priority": 4, + "parents": [ + 129402 + ], + "children": [], + "area": 34613.374444, + "iscrowd": 0, + "segmentation": [], + "text": "Studying DNA methylation patterns in biological samples using next\ngeneration sequencing (NGS) methods are becoming increasingly\ncommon. There were several tools available to detect differentially\nmethylated cytosine (DMC) or differentially methylated region (DMR).\nHowever, detections of DMR based on gene body features associated\nwith CpG islands are scarce, such as the DMRs in a promoter (DMP),\nexon (DME) and intron (DMI), or a specific gene (DMG). Here, we\nprovide an R package that calculates methylation levels using bisulfite\nsequencing datasets like whole genome bisulfite sequencing (WGBS)\nor reduced representation bisulfite sequencing (RRBS) within a single\ngene as one entity or gene body interacted with CpG islands, and then\nhelp identify the gene-based differentially methylated regions\n(GeneDMRs) or other interactive regions." + }, + { + "id": 129403, + "strid": "b8fa5669-47b6-41dc-afb7-160811fbabed", + "image_id": 205532, + "image_name": "15290.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 64.632, + 1488.714, + 227.38299999999998, + 63.61999999999989 + ], + "priority": 5, + "parents": [ + 129425 + ], + "children": [ + 129407, + 129408, + 129418, + 129409, + 129417 + ], + "area": 96218.563248, + "iscrowd": 0, + "segmentation": [], + "text": "Method" + }, + { + "id": 129407, + "strid": "54dc68e2-2cd1-4f01-b4c8-de384fea18ae", + "image_id": 205532, + "image_name": "15290.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 42.42, + 1561.211, + 1591.937, + 349.1769999999999 + ], + "priority": 6, + "parents": [ + 129403 + ], + "children": [], + "area": 66226.57062, + "iscrowd": 0, + "segmentation": [], + "text": "The gene-based regions could be divided into single window, gene,\npromoter, exon, intron, CpG island and CpG island shore and their\ninteractive feature regions including gene-CpG island, gene-CpG island\nshore, promoter-CpG island, promoter-CpG island shore, exon-CpG\nisland, exon-CpG island shore, intron-CpG island and intron-CpG island\nshore." + }, + { + "id": 129417, + "strid": "949a34c6-a8fc-481b-aa25-db31547a81a3", + "image_id": 205532, + "image_name": "15290.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 56.832, + 1934.618, + 1129.123, + 342.41100000000006 + ], + "priority": 7, + "parents": [ + 129403 + ], + "children": [ + 129423 + ], + "area": 109948.210176, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 129423, + "strid": "7e261196-5511-43ea-8e15-810b6347c064", + "image_id": 205532, + "image_name": "15290.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1206.676, + 1925.664, + 441.153, + 433.1690000000001 + ], + "priority": 8, + "parents": [ + 129417 + ], + "children": [], + "area": 2323652.5328639997, + "iscrowd": 0, + "segmentation": [], + "text": "The analyzed targets in the\nGeneDMRs package including widows,\ngenes (promoters, exons, introns),\nCpG islands (CpGis, Shores) and the\ninteractive feature regions (e.g., A:\nPromoter-Shore1, B: Exon1-Shore1, C:\nExon1-CpGi, D: Intron1-CpGi, E:\nExon2-CpGi, F: Exon2-Shore2, A + B:\nGene-Shore1, C + D + E: Gene-CpGi,\nF + G: Gene-Shore2)." + }, + { + "id": 129408, + "strid": "05b1ac33-928b-4cee-a335-12a9b654b2bd", + "image_id": 205532, + "image_name": "15290.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 56.974, + 2349.631, + 1567.731, + 380.36799999999994 + ], + "priority": 9, + "parents": [ + 129403 + ], + "children": [], + "area": 133867.87659399997, + "iscrowd": 0, + "segmentation": [], + "text": "The statistical model:\nn m m\nMR;i; TR;;\n2 MRiy * Wj and Wi; = 20 TR\n= LT TR Ley\" TRi\nwhere MR,; and TR;; are methylated and total reads number of the involved cytosine/DMC\n\nj sites at a given gene/CpGi/other region of individual i, m is total number of cytosine/DMC\nsites involved in this region, n is the total individual number of one group and W;,; is the\n\nweight of reads of the involved cytosine/DMC j sites of individual i." + }, + { + "id": 129409, + "strid": "7761521f-b306-4225-be64-d8dfc9cdce72", + "image_id": 205532, + "image_name": "15290.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 63.84, + 2856.606, + 429.908, + 414.4670000000001 + ], + "priority": 10, + "parents": [ + 129403 + ], + "children": [], + "area": 182365.72704000003, + "iscrowd": 0, + "segmentation": [], + "text": "In (=) =u+ Tj +e,\n\nwhere Tr is the\nmethylation mean at a\ngiven window or gene-\nbased region or site, u is\nthe intercept, T; is the\ngroup indicator and e is\nthe residual." + }, + { + "id": 129418, + "strid": "b42d5c9b-43f8-4560-a4e0-e000be82d691", + "image_id": 205532, + "image_name": "15290.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 507.922, + 2768.405, + 1123.04, + 588.9829999999997 + ], + "priority": 11, + "parents": [ + 129403 + ], + "children": [], + "area": 1406133.80441, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 129404, + "strid": "7439e8cd-6410-4dc5-9c4f-4f2c5391907b", + "image_id": 205532, + "image_name": "15290.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 72.237, + 3451.023, + 751.192, + 73.89499999999998 + ], + "priority": 12, + "parents": [ + 129425 + ], + "children": [ + 129410, + 129414, + 129416, + 129415, + 129419, + 129420, + 129411 + ], + "area": 249291.54845099998, + "iscrowd": 0, + "segmentation": [], + "text": "Results and discussion" + }, + { + "id": 129410, + "strid": "dfce2205-a92c-4d5e-a918-0e4f8e4e4e6a", + "image_id": 205532, + "image_name": "15290.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 52.715, + 3540.278, + 1543.447, + 174.8420000000001 + ], + "priority": 13, + "parents": [ + 129404 + ], + "children": [], + "area": 186625.75477, + "iscrowd": 0, + "segmentation": [], + "text": "Generally, the detected DMGs were more representative of the\nmethylation level than the DMCs within those genes and tended to be\nmore biologically relevant." + }, + { + "id": 129419, + "strid": "43319796-d780-4a0a-b04f-ae876f266e59", + "image_id": 205532, + "image_name": "15290.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 51.329, + 3734.665, + 862.59, + 381.4390000000003 + ], + "priority": 14, + "parents": [ + 129404 + ], + "children": [ + 129421 + ], + "area": 191696.619785, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 129421, + "strid": "0b10cf2b-fad3-4334-910e-a60315cee7a5", + "image_id": 205532, + "image_name": "15290.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 61.357, + 4137.755, + 862.419, + 55.32499999999982 + ], + "priority": 15, + "parents": [ + 129419 + ], + "children": [], + "area": 253880.233535, + "iscrowd": 0, + "segmentation": [], + "text": "Manhattan plots for all genes. Note: The red line indicates the significant level\nof Q-value < 0.01." + }, + { + "id": 129420, + "strid": "983839c5-0c19-4edf-a0a9-e6f1ed63be8e", + "image_id": 205532, + "image_name": "15290.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1012.541, + 3777.001, + 599.937, + 218.74299999999994 + ], + "priority": 16, + "parents": [ + 129404 + ], + "children": [ + 129422 + ], + "area": 3824368.3695410006, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 129422, + "strid": "1806d02c-ccf0-4702-b3bf-192671008c80", + "image_id": 205532, + "image_name": "15290.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1014.678, + 4058.275, + 622.6370000000001, + 119.04199999999992 + ], + "priority": 17, + "parents": [ + 129420 + ], + "children": [], + "area": 4117842.36045, + "iscrowd": 0, + "segmentation": [], + "text": "Methylation patterns of all DMGs for different groups in\ndifferent CpG island regions. Note: P value is calculated\nby the methylation comparison between CpG island and\nCpG island shore with Student’s t-tests." + }, + { + "id": 129411, + "strid": "7aac06ae-0e47-4dec-a9f8-75fe1b782c95", + "image_id": 205532, + "image_name": "15290.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 68.364, + 4238.342, + 1576.211, + 351.0460000000003 + ], + "priority": 18, + "parents": [ + 129404 + ], + "children": [], + "area": 289750.012488, + "iscrowd": 0, + "segmentation": [], + "text": "GeneDMRs package can only use the DMCs to recalculate the\nmethylation mean by replacing the original cytosine sites. It is because\nthe total number of hypotheses affects the Q-values by the rank of\ncombined P-values, so statistical efficiency can be potentially improved\nby removing globally unmethylated sites with less methylation\ndifferences." + }, + { + "id": 129415, + "strid": "2be40a1e-9a06-43af-af2b-c8177b706004", + "image_id": 205532, + "image_name": "15290.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1744.935, + 495.87, + 992.2350000000001, + 1026.005 + ], + "priority": 19, + "parents": [ + 129404 + ], + "children": [ + 129424 + ], + "area": 865260.91845, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 129424, + "strid": "d03c33e8-9bae-48df-a350-505f39ccb97c", + "image_id": 205532, + "image_name": "15290.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1788.421, + 1567.6, + 922.356, + 148.04300000000012 + ], + "priority": 20, + "parents": [ + 129415 + ], + "children": [], + "area": 2803528.7596, + "iscrowd": 0, + "segmentation": [], + "text": "Circular graph of the global DMC-based methylation levels. Note: From the\noutermost track to innermost circle, the circles indicate genome chromosomes (i.e.,\nmouse), DMGs, gene densities, CpG island densities, CpG island shore densities\nand methylation levels. The densities and methylation levels were calculated by\n1,000,000 base pair (bp) windows." + }, + { + "id": 129414, + "strid": "55ddfd9c-df56-489c-8253-6501e22e26bf", + "image_id": 205532, + "image_name": "15290.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2768.56, + 526.886, + 516.029, + 1311.312 + ], + "priority": 21, + "parents": [ + 129404 + ], + "children": [], + "area": 1458715.5041599998, + "iscrowd": 0, + "segmentation": [], + "text": "The GO terms can be\nvisualized in\nno/one/two categories\nby incorporating\nhyper/hypo-methylated\nand up/down-\nregulated gene\ninformation. Thus,\nbased on the DMGs\nand enrichments for\nGO term and pathway,\nGeneDMRs package\ncan help to detect the\nspecific significant\nregions, reveal the\nbiological mechanism\nand enhance the\nprevious studies that\nmethylation pattern\nchanges in specific-\nregions were involved\nin causing diseases." + }, + { + "id": 129416, + "strid": "859a2fb6-f8ad-47e1-9b90-f669a169c59c", + "image_id": 205532, + "image_name": "15290.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1762.601, + 1864.217, + 1491.0319999999997, + 821.094 + ], + "priority": 22, + "parents": [ + 129404 + ], + "children": [], + "area": 3285870.7484170003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 129405, + "strid": "b0779a52-d5d4-4bbb-9e3b-a658df1e290f", + "image_id": 205532, + "image_name": "15290.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1745.762, + 2778.682, + 311.414, + 69.66800000000012 + ], + "priority": 23, + "parents": [ + 129425 + ], + "children": [ + 129413 + ], + "area": 4850917.445684, + "iscrowd": 0, + "segmentation": [], + "text": "Summary" + }, + { + "id": 129413, + "strid": "8322a659-1d38-48b4-aea5-972ece41cd6e", + "image_id": 205532, + "image_name": "15290.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1728.204, + 2872.302, + 1555.5910000000001, + 866.1169999999997 + ], + "priority": 24, + "parents": [ + 129405 + ], + "children": [], + "area": 4963923.805608, + "iscrowd": 0, + "segmentation": [], + "text": "GeneDMRs, a user-friendly R package, can facilitate computing gene\nbased methylation rate using NGS-based methylome data. This\npackage aims to analyze the methylation levels in\ngene/promoter/exon/intron/CpG island/CpG island shore and their\ninteractive regions. Then, the differentially hyper/nypo-methylated\ngenes can be visualized for enrichments of GO terms and pathways\nand reveal the biological mechanism accordingly. Such gene-based\nmethylation analyses contributes to interpreting complex interplay\nbetween methylation levels and gene expression differences or\n\nsimilarities across physiological conditions or disease states." + }, + { + "id": 129412, + "strid": "887ae134-f17f-4bc4-af35-323b9f624ea9", + "image_id": 205532, + "image_name": "15290.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1726.634, + 3837.683, + 1512.29, + 124.81899999999996 + ], + "priority": 25, + "parents": [ + 129425 + ], + "children": [], + "area": 6626273.949022, + "iscrowd": 0, + "segmentation": [], + "text": "Availability and implementation\nGeneDMRs is freely available at https://github.com/xiaowangCN/GeneDMRs" + }, + { + "id": 56817, + "strid": "c69a8018-c8a8-4bdc-bcc1-c5df6fdb474a", + "image_id": 202740, + "image_name": "119170.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 10.88, + 31.41, + 100.29, + 50.150000000000006 + ], + "priority": -1, + "parents": [], + "children": [ + 56806, + 56804, + 56803, + 56802, + 56801, + 56800, + 56805 + ], + "area": 341.74080000000004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 56800, + "strid": "0b53c2be-6b24-4779-960d-2164ee52d5ed", + "image_id": 202740, + "image_name": "119170.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 142.84, + 20.39, + 838.554, + 85.546 + ], + "priority": 1, + "parents": [ + 56817 + ], + "children": [], + "area": 2912.5076000000004, + "iscrowd": 0, + "segmentation": [], + "text": "A Neutrophil Phenotype Model for Extracorporeal\na Treatment of Sepsis" + }, + { + "id": 56801, + "strid": "46a3cab0-f972-4306-ab6c-ae35ad08e03d", + "image_id": 202740, + "image_name": "119170.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 37.895, + 125.549, + 1050.15, + 87.846 + ], + "priority": 2, + "parents": [ + 56817 + ], + "children": [], + "area": 4757.679355, + "iscrowd": 0, + "segmentation": [], + "text": "A Malkin, R Sheehan’, S Mathew’, H Redl#-G Clermont’? EEG\n1University of Pittsburgh, Pittsburgh USA, ? Ludwig Boltzmann’ Institute for Experimental and\nClinical Traumatology; Vienna, Austria, 3? University of Pittsburgh Medical Center, Pittsburgh USA" + }, + { + "id": 56802, + "strid": "1ee4d93a-853c-4690-8a38-c561edeaccf3", + "image_id": 202740, + "image_name": "119170.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 164.791, + 238.741, + 230.861, + 35.09 + ], + "priority": 3, + "parents": [ + 56817 + ], + "children": [ + 56813 + ], + "area": 39342.368131, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 56813, + "strid": "0fa6222e-ac94-493a-9901-f8a4c81675d9", + "image_id": 202740, + "image_name": "119170.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 34.641, + 282.71, + 466.17, + 195.288 + ], + "priority": 4, + "parents": [ + 56802 + ], + "children": [], + "area": 9793.357109999999, + "iscrowd": 0, + "segmentation": [], + "text": "Neutrophils play a central role in eliminating bacterial\npathogens in sepsis, but may also contribute to end-\norgan damage. Interleukin-8 (IL-8), a key modulator of\nneutrophil function, signals through neutrophil specific\nsurface receptors CXCR-1 and CXCR-2. In this study a\nmechanistic mathematical model was used to evaluate\nand deploy an extracorporeal sepsis treatmentwwhich\nmodulates CXCR-1/2 levels." + }, + { + "id": 56803, + "strid": "82f0b975-5f77-40fa-a114-7544775147a7", + "image_id": 202740, + "image_name": "119170.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 763.067, + 237.135, + 166.97800000000007, + 37.774 + ], + "priority": 5, + "parents": [ + 56817 + ], + "children": [ + 56812 + ], + "area": 180949.893045, + "iscrowd": 0, + "segmentation": [], + "text": "Methods" + }, + { + "id": 56812, + "strid": "74e67c56-a852-4f67-a005-a4d97ed347cb", + "image_id": 202740, + "image_name": "119170.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 597.786, + 282.244, + 487.57900000000006, + 220.92700000000002 + ], + "priority": 6, + "parents": [ + 56803 + ], + "children": [], + "area": 168721.511784, + "iscrowd": 0, + "segmentation": [], + "text": "A simplified mechanistic mathematical model of IL-8\nmediated activation of CXCR-1/2 receptors was\ndeveloped using ordinary differential equations. The\nmathematical model was calibrated using’experimental\ndata from baboons administered a two-hour infusion of E\ncoli and followed for a maximumyof.28 days. An\nextracorporeal intervention was‘then implemented by\nintroducing a trapped receptorstate which limits IL-8\nsignaling through CXCR-1/2." + }, + { + "id": 56804, + "strid": "d7486e1e-2346-421e-a406-e28696b37f60", + "image_id": 202740, + "image_name": "119170.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 493.72, + 514.108, + 139.23299999999995, + 41.19399999999996 + ], + "priority": 7, + "parents": [ + 56817 + ], + "children": [ + 56811, + 56816, + 56810, + 56815, + 56809, + 56814 + ], + "area": 253825.40175999998, + "iscrowd": 0, + "segmentation": [], + "text": "Results" + }, + { + "id": 56810, + "strid": "3a2df9d5-3cde-4b12-99ef-c741ba22b73e", + "image_id": 202740, + "image_name": "119170.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 44.073, + 560.728, + 487.635, + 230.50599999999997 + ], + "priority": 8, + "parents": [ + 56804 + ], + "children": [], + "area": 24712.965143999998, + "iscrowd": 0, + "segmentation": [], + "text": "Computational Model Diagram\nReceptor level dynamics and\\systemic parameters are\ncoupled with multiple’neutrophil phenotypes to generate\ndynamic populations of activated neutrophils which\nreduce pathogen/oad, and/or primed neutrophils which\ncause adverse tissue damage when misdirected. The\nmodel belowsshows neutrophil phenotype transition\n(blue) .in’response to pathogen load and subsequent\nneutrophil surface receptor states." + }, + { + "id": 56814, + "strid": "fc1650b5-50f9-4d95-8d3c-3f8d18c1abd4", + "image_id": 202740, + "image_name": "119170.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 16.424, + 797.901, + 530.74, + 338.2879999999999 + ], + "priority": 9, + "parents": [ + 56804 + ], + "children": [], + "area": 13104.726024, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 56811, + "strid": "e7e3a59d-1228-4d53-a8cd-c432b76176e6", + "image_id": 202740, + "image_name": "119170.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 594.604, + 560.838, + 489.635, + 203.75400000000002 + ], + "priority": 10, + "parents": [ + 56804 + ], + "children": [], + "area": 333476.518152, + "iscrowd": 0, + "segmentation": [], + "text": "Parameter Distributions\nOf 16 baboons, 11 (69%) die, 6 (38%) within one day of\nbacterial'infusion. The model was well calibrated to the\ndata from survivors and non-survivors. Sensitivity analysis\nidentified six model parameters, out of 21, as key\ndeterminants of mortality. Key differences between\nsurvivor and non-survivor parameters are displayed\nbelow." + }, + { + "id": 56815, + "strid": "f0f3d05c-488e-445a-a363-9577660f0ba6", + "image_id": 202740, + "image_name": "119170.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 587.738, + 774.949, + 482.1400000000001, + 348.861 + ], + "priority": 11, + "parents": [ + 56804 + ], + "children": [], + "area": 455466.975362, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 56809, + "strid": "088c2ec8-7468-4483-b09c-608073e1f7bb", + "image_id": 202740, + "image_name": "119170.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 27.445, + 1147.424, + 1068.3, + 160.73399999999992 + ], + "priority": 12, + "parents": [ + 56804 + ], + "children": [], + "area": 31491.05168, + "iscrowd": 0, + "segmentation": [], + "text": "Extracorporeal Treatment Implementation\n\nThe modél, produced probabilistic predications of the extracorporeal treatment’s impact on mortality. Treatment time of onset\nand ‘duration proved to have a substantial impact on mortality. An intervention introduced within 1 hour.of infection for a 72\nhourduration results in the survivor population increasing from 31% to 61%. Treatment efficacy quickly diminishes if not\nintroduced within 15 hours of infection. Treatmentduration of 48 hours reduces maximal effect to39% survival. Significant\nharm is possible with treatment durations ranging from 5-24 hours, which may reduce survival to 21%." + }, + { + "id": 56816, + "strid": "bb802dbc-9c40-44d4-8fcb-1afc95b2def6", + "image_id": 202740, + "image_name": "119170.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 169.195, + 1330.913, + 789.988, + 400.3800000000001 + ], + "priority": 13, + "parents": [ + 56804 + ], + "children": [], + "area": 225183.825035, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 56805, + "strid": "65b8a61d-f0ab-4e57-bddc-5751ccb07e1e", + "image_id": 202740, + "image_name": "119170.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 174.471, + 1755.276, + 209.40700000000004, + 40.39200000000005 + ], + "priority": 14, + "parents": [ + 56817 + ], + "children": [ + 56807 + ], + "area": 306244.758996, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusion" + }, + { + "id": 56807, + "strid": "bb0b6ecd-4261-4281-b482-4402422500de", + "image_id": 202740, + "image_name": "119170.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 34.498, + 1812.109, + 485.06800000000004, + 144.64599999999996 + ], + "priority": 15, + "parents": [ + 56805 + ], + "children": [], + "area": 62514.13628199999, + "iscrowd": 0, + "segmentation": [], + "text": "In severe sepsis, an extracorporeal'treatment which\nmodulates CXCR-1/2 levels has therapeutic potential, but\nalso potential for harm. Furtherdevelopment of the\nmathematical model willhelp guide optimal device\ndevelopment and determine which patient populations\nshould be targeted. by treatment." + }, + { + "id": 56806, + "strid": "8470626a-d5d5-4789-b62d-efd50cfa83cc", + "image_id": 202740, + "image_name": "119170.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 663.256, + 1754.657, + 367.7589999999999, + 43.047000000000025 + ], + "priority": 16, + "parents": [ + 56817 + ], + "children": [ + 56808 + ], + "area": 1163786.783192, + "iscrowd": 0, + "segmentation": [], + "text": "Acknowledgements" + }, + { + "id": 56808, + "strid": "1cdb9d8b-da0d-46b0-9fc5-15ea95f066d2", + "image_id": 202740, + "image_name": "119170.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 597.235, + 1816.081, + 435.73400000000004, + 95.75700000000006 + ], + "priority": 17, + "parents": [ + 56806 + ], + "children": [], + "area": 1084627.136035, + "iscrowd": 0, + "segmentation": [], + "text": "| would like to thank the Gerald E. McGinnis\nBioengineering Graduate Fellowship and the NIH\nCardiovascular Bioengineering Training Program for\nfinancial-support." + }, + { + "id": 159124, + "strid": "747b4067-ccd7-4d29-af4e-e0ee618dd42c", + "image_id": 206716, + "image_name": "6316.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 118.49, + 62.55, + 120.39, + 78.25000000000001 + ], + "priority": -1, + "parents": [], + "children": [ + 159112, + 159113, + 159114, + 159115, + 159116, + 159122, + 159095, + 159120, + 159119 + ], + "area": 7411.549499999999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 159113, + "strid": "9eec4b6e-16c5-469a-b569-9950a4f62a01", + "image_id": 206716, + "image_name": "6316.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 380.221, + 539.239, + 2545.148, + 155.341 + ], + "priority": 1, + "parents": [ + 159124 + ], + "children": [], + "area": 205029.99181900002, + "iscrowd": 0, + "segmentation": [], + "text": "CpG island erosion, Polycomb occupancy, and sequence motif enrichment at\nbivalent promoters in mammalian embryonic stem cells" + }, + { + "id": 159095, + "strid": "6e5dafe6-8ca1-487e-bf73-6c73f6fbb4b0", + "image_id": 206716, + "image_name": "6316.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 1850.244, + 152.999, + 1434.6000000000001, + 250.56700000000004 + ], + "priority": 2, + "parents": [ + 159124 + ], + "children": [], + "area": 283085.48175599996, + "iscrowd": 0, + "segmentation": [], + "text": "Anna Mantsoki', Guillaume Devailly', Anagha Joshi'\n'The Roslin Institute and Royal (Dick) School of Veterinary\nStudies, University of Edinburgh, Easter Bush, Midlothian,\n\nEH25 9RG, Email: anna.mantsoki@roslin.ed.ac.uk" + }, + { + "id": 159114, + "strid": "dab65e22-f573-462e-a3f8-3132e1aee753", + "image_id": 206716, + "image_name": "6316.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 726.598, + 719.523, + 390.4169999999999, + 57.349000000000046 + ], + "priority": 3, + "parents": [ + 159124 + ], + "children": [ + 159098, + 159096, + 159118, + 159117, + 159099 + ], + "area": 522803.972754, + "iscrowd": 0, + "segmentation": [], + "text": "INTRODUCTION" + }, + { + "id": 159096, + "strid": "1b434069-443b-448c-8257-0a7d72cc4355", + "image_id": 206716, + "image_name": "6316.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 86.658, + 800.339, + 1672.354, + 275.32499999999993 + ], + "priority": 4, + "parents": [ + 159114 + ], + "children": [], + "area": 69355.77706200001, + "iscrowd": 0, + "segmentation": [], + "text": "Eukaryotic gene regulation during development directs the lineage commitment of pluripotent cells.\nHistone modifications are the epigenetic marks that empower regulatory elements, such as promoters\nand enhancers to control the expression of key developmental factors. Co-existence of histone H3\nlysine 4 tri-methylation (H3K4me3) and histone H3 lysine 27 tri-methylation (H3K27me3), associated\nrespectively with activation and silencing of transcription, is detected at many developmental\npromoters in embryonic stem cells (ESCs), giving rise to bivalency. In our project we are trying to\ndecipher how these bivalent domains are formed and lost through the process of differentiation." + }, + { + "id": 159098, + "strid": "21a0d7a3-b551-4cb9-b22a-0ee51d9c3e3c", + "image_id": 206716, + "image_name": "6316.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 154.376, + 1096.191, + 755.694, + 529.2169999999999 + ], + "priority": 5, + "parents": [ + 159114 + ], + "children": [], + "area": 169225.58181600002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 159117, + "strid": "25053893-13fe-4dd7-8f1a-61c8c7c9981c", + "image_id": 206716, + "image_name": "6316.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 208.781, + 1632.008, + 481.31300000000005, + 178.15599999999995 + ], + "priority": 6, + "parents": [ + 159114 + ], + "children": [], + "area": 340732.262248, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 159099, + "strid": "af450619-41a9-46c1-b44b-58768967582f", + "image_id": 206716, + 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"category_id": 5, + "category_name": "Section", + "bbox": [ + 445.324, + 2787.516, + 767.079, + 43.820000000000164 + ], + "priority": 22, + "parents": [ + 159124 + ], + "children": [ + 159123 + ], + "area": 1241347.7751840001, + "iscrowd": 0, + "segmentation": [], + "text": "RESULI 2- CpG isiand enricnment" + }, + { + "id": 159123, + "strid": "1926bba5-f2ff-4310-a5f9-94773e7dfe6e", + "image_id": 206716, + "image_name": "6316.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 59.05, + 2874.51, + 1513.832, + 1289.6180000000004 + ], + "priority": 23, + "parents": [ + 159119 + ], + "children": [], + "area": 169739.8155, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 159120, + "strid": "2571912f-defb-4643-9b3c-7ccb0e163e75", + "image_id": 206716, + "image_name": "6316.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1794.629, + 2768.319, + 1385.4679999999998, + 97.52300000000014 + ], + "priority": 24, + "parents": [ + 159124 + ], + "children": [ + 159121 + ], + "area": 4968105.558650999, + "iscrowd": 0, + "segmentation": [], + "text": "RESULT 3- Transcription factors occupancy and de-novo motif\nenrichment" + }, + { + "id": 159121, + "strid": "09415384-dacb-48e6-bab9-1ae9fc54a200", + "image_id": 206716, + "image_name": "6316.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1710.057, + 2872.492, + 1557.9059999999997, + 1118.174 + ], + "priority": 25, + "parents": [ + 159120 + ], + "children": [], + "area": 4912125.0520440005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 159122, + "strid": "012fc5f2-0a4b-4e95-9dec-8945d2e260c5", + "image_id": 206716, + "image_name": "6316.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2192.562, + 4002.948, + 655.1179999999999, + 34.134000000000015 + ], + "priority": 26, + "parents": [ + 159124 + ], + "children": [ + 159097 + ], + "area": 8776711.672775999, + "iscrowd": 0, + "segmentation": [], + "text": "CONCLUSION AND FUTURE WORK" + }, + { + "id": 159097, + "strid": "3877e86c-0bb3-4603-9388-714849147025", + "image_id": 206716, + "image_name": "6316.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1730.852, + 4058.976, + 1526.626, + 366.4180000000001 + ], + "priority": 27, + "parents": [ + 159122 + ], + "children": [], + "area": 7025486.727552, + "iscrowd": 0, + "segmentation": [], + "text": "Over 85% of H3K27me3 marked promoters were bivalent in human and mouse ES cells. HC bivalent promoters\nwere enriched for developmental factors and were highly likely to be differentially expressed upon transcription\nfactor perturbation; Murine HC bivalent promoters were occupied by both Polycomb repressive component\nclasses (PRC1 and PRC2) and grouped into four distinct clusters with different biological functions; HC bivalent\nand active promoters were CpG rich while H3K27me3-only promoters lacked CpG islands. Binding enrichment\nof distinct sets of regulators distinguished bivalent from active promoters. Moreover, a ‘TCCCC’ sequence motif\nwas specifically enriched in bivalent promoters. In the next steps of our study, we will focus on the analysis of\nbivalent promoters from cells of high potency to tissue specific cell types (already gathered data) and the\ndistinction of their properties. As a final point, after completing the same analysis for both promoters and\nenhancers (H3K4me1 histone mark) we will compare the outcomes and detect the differences in their evolution." + }, + { + "id": 159112, + "strid": "b42c8a7b-e1c0-4cfe-94aa-62d07172ec1c", + "image_id": 206716, + "image_name": "6316.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 651.317, + 4236.905, + 266.193, + 33.177999999999884 + ], + "priority": 28, + "parents": [ + 159124 + ], + "children": [ + 159111 + ], + "area": 2759568.253885, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 159111, + "strid": "8b23bd88-0b7d-4a3d-96db-6c752ea65fc2", + "image_id": 206716, + "image_name": "6316.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 47.812, + 4271.792, + 1267.145, + 163.02400000000034 + ], + "priority": 29, + "parents": [ + 159112 + ], + "children": [], + "area": 204242.919104, + "iscrowd": 0, + "segmentation": [], + "text": "Bernstein, B. et al., 2006, Cell, 125(2), pp.315-326, Mikkelsen, T. et al., 2007, Nature, 448(7153), pp.553-560,\nVoigt, P., Tee, W.-W. & Reinberg, D., 2013, Genes & development, 27(12), pp.1318-1338 ,\n\nPan, G. et al., 2007, Cell stem cell, 1(3), pp.299-312, Ku, M. et al., 2008, {PLoS} genetics, 4(10),\n\nZhang, Y. et al. Nature 504, 306-10 (2013), Brookes, E. & Pombo, A. EMBO reports 10, 1213-1219 (2009),\nBrookes, Emily et al.Cell Stem Cell , Volume 10 , Issue 2 , 157 - 170" + }, + { + "id": 136103, + "strid": "4a11cd3e-1a11-4871-a424-96962f154d1f", + "image_id": 205777, + "image_name": "15898.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 434.13, + 30.54, + 105.07000000000005, + 215.14000000000001 + ], + "priority": -1, + "parents": [], + "children": [ + 136092, + 136094, + 136088, + 136090, + 136089, + 136087, + 136093, + 136091 + ], + "area": 13258.3302, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 136087, + "strid": "6a04afd8-512d-4448-b163-22d5767293e4", + "image_id": 205777, + "image_name": "15898.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 656.301, + 76.342, + 2530.997, + 224.26600000000002 + ], + "priority": 1, + "parents": [ + 136103 + ], + "children": [], + "area": 50103.330942, + "iscrowd": 0, + "segmentation": [], + "text": "A tailored approach to fusion transcript identification\nincreases diagnosis of rare inherited disease" + }, + { + "id": 136088, + "strid": "28b78011-ee25-4fc8-bc16-7179a018a9e3", + "image_id": 205777, + "image_name": "15898.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 478.839, + 419.468, + 2833.007, + 109.29599999999999 + ], + "priority": 2, + "parents": [ + 136103 + ], + "children": [], + "area": 200857.637652, + "iscrowd": 0, + "segmentation": [], + "text": "Gavin R. Oliver, Xiaojia Tang, Laura E. Schultz-Rogers, Noemi Vidal-Folch, W. Garrett Jenkinson, Tanya L. Schwab, Krutika Gaonkar, Margot A.\nCousin, Asha Nair, Shubham Basu, Pritha Chanana, Devin Oglesbee, Eric W. Klee" + }, + { + "id": 136089, + "strid": "62250831-c632-40ad-9685-2d38434cbc73", + "image_id": 205777, + "image_name": "15898.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 326.402, + 692.681, + 193.47200000000004, + 52.764999999999986 + ], + "priority": 3, + "parents": [ + 136103 + ], + "children": [ + 136095 + ], + "area": 226092.463762, + "iscrowd": 0, + "segmentation": [], + "text": "Abstract" + }, + { + "id": 136095, + "strid": "1e5283de-931a-444b-a541-8384fbd08f1a", + "image_id": 205777, + "image_name": "15898.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 51.096, + 811.669, + 729.026, + 2620.145 + ], + "priority": 4, + "parents": [ + 136089 + ], + "children": [], + "area": 41473.03922399999, + "iscrowd": 0, + "segmentation": [], + "text": "Background\n\nRNA sequencing has been proposed as a\nmeans of increasing diagnostic rates in\nstudies of undiagnosed rare inherited\ndisease. Recent studies have reported\ndiagnostic improvements in the range of\n7.5-35% by profiling splicing, gene\nexpression quantification and allele\nspecific expression. To-date however, no\nstudy has systematically assessed the\npresence of gene-fusion transcripts in\ncases of germline disease. Fusion\ntranscripts are routinely identified in\ncancer studies and are increasingly\nrecognized as having diagnostic,\nprognostic or therapeutic relevance.\nIsolated reports exist of fusion transcripts\nbeing detected in cases of developmental\nand neurological phenotypes, and thus,\nsystematic application of fusion detection\nto germline conditions may further\nincrease diagnostic rates. However,\ncurrent fusion detection methods are\nunsuited to the investigation of germline\ndisease due to performance biases arising\nfrom their development using tumor, cell-\nline or in-silico data.\n\nMethods\n\nWe describe a tailored approach to fusion\ncandidate identification and prioritization in\na cohort of 47 undiagnosed, suspected\ninherited disease patients. We modify an\nexisting fusion transcript detection\nalgorithm by eliminating its cell line-\nderived filtering steps, and instead,\nprioritize candidates using a custom\nworkflow that integrates genomic and\ntranscriptomic sequence alignment,\nbiological and technical annotations,\ncustomized categorization logic, and\nphenotypic prioritization.\n\nResults\n\nWe demonstrate that our approach to\nfusion transcript identification and\nprioritization detects genuine fusion events\nexcluded by standard analyses and\nefficiently removes phenotypically\nunimportant candidates and false positive\nevents, resulting in a reduced candidate\nlist enriched for events with potential\nphenotypic relevance. We describe the\nsuccessful genetic resolution of two\npreviously undiagnosed disease cases\nthrough the detection of pathogenic fusion\ntranscripts. Furthermore, we report the\nexperimental validation of five additional\ncases of fusion transcripts with potential\nphenotypic relevance." + }, + { + "id": 136090, + "strid": "ab77773b-3e33-435b-9c98-31d92e9c5450", + "image_id": 205777, + "image_name": "15898.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1735.159, + 698.01, + 222.34400000000005, + 47.58299999999997 + ], + "priority": 5, + "parents": [ + 136103 + ], + "children": [ + 136101, + 136096 + ], + "area": 1211158.3335900002, + "iscrowd": 0, + "segmentation": [], + "text": "Methology" + }, + { + "id": 136101, + "strid": "74733fc7-9c0e-45cc-9cc8-86ff9f82d005", + "image_id": 205777, + "image_name": "15898.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 892.894, + 814.922, + 1916.318, + 1258.382 + ], + "priority": 6, + "parents": [ + 136090 + ], + "children": [], + "area": 727638.964268, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 136096, + "strid": "d21fc6a1-7978-4a47-ad3e-b6f9c14a72d8", + "image_id": 205777, + "image_name": "15898.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 889.86, + 2124.326, + 1844.8429999999998, + 239.0369999999998 + ], + "priority": 7, + "parents": [ + 136090 + ], + "children": [], + "area": 1890352.7343600001, + "iscrowd": 0, + "segmentation": [], + "text": "Unfiltered results from TopHat fusion were BLASTed, annotated and input to a candidate classification\nworkflow. The median number of events per sample in each category is shown. All candidates classified as\npotential fusions or read-through events, proceeded into a final review stage that determined phenotypic\nrelevance of the genes to the patient condition using both automated PCAN analysis and manual review.\nCandidates classified as most phenotypically relevant were selected for follow-up validation." + }, + { + "id": 136092, + "strid": "5b7dfb94-d45b-43ea-a16d-dd41dcf565b6", + "image_id": 205777, + "image_name": "15898.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1527.507, + 2454.822, + 637.9699999999998, + 50.858000000000175 + ], + "priority": 8, + "parents": [ + 136103 + ], + "children": [ + 136102, + 136097 + ], + "area": 3749757.7887540003, + "iscrowd": 0, + "segmentation": [], + "text": "Diagnostic Fusion Transcripts" + }, + { + "id": 136102, + "strid": "60a07506-dab7-4c33-bc33-7b946441b31b", + "image_id": 205777, + "image_name": "15898.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 867.725, + 2544.436, + 953.035, + 945.2199999999998 + ], + "priority": 9, + "parents": [ + 136092 + ], + "children": [], + "area": 2207870.7281000004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 136097, + "strid": "2bd9035b-3a3f-42cd-86bb-e1031cc9deb0", + "image_id": 205777, + "image_name": "15898.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1836.167, + 2584.698, + 935.9949999999999, + 849.2959999999998 + ], + "priority": 10, + "parents": [ + 136092 + ], + "children": [], + "area": 4745937.172565999, + "iscrowd": 0, + "segmentation": [], + "text": "A) ASAMD12-EXT1 fusion identified in Patient 37 whose phenotype included\nmultiple exostoses. Multiple exostoses are most often attributed to autosomal\ndominant mutations in EXT1 and EXT2 but extensive clinical testing failed to\nidentify any variants of interest in either gene. RNA-Seq identified a fusion\ncandidate which might be explained by an interstitial deletion based on the\ngenes’ orientation and position on chromosome 8 and would lead to loss of\nfunction of both EXT1 and SAMD12 due to loss of coding potential at the\nfusion boundary. Despite clinical aCGH and MLPA results initially indicating no\ndeletion affecting the putatively conjoined genes, reevaluation of clinical\naCGH results appeared suggestive of a mosaic deletion of approximately 604\nkb at chr8:118960168—119569348. The deletion was subsequently validated\nby several orthogonal methods and determined to be diagnostic of the\nmultiple exostoses phenotype. The SAMD12-EXT1 fusion was not detected by\nstandard TopHat filters.\n\nB) Reciprocal ATM-SLC35F2 and SLC35F2-ATM fusions detected in Patient\n6, with a severe combined immunodeficiency phenotype. The patient carried a\npaternally inherited pathogenic ATM variant for which a second hit was sought\ndue to the autosomal recessive nature of ATM mutations. RNA-Seq revealed\nreciprocal fusions that were expected to retain their protein-coding potential\nbut lead to aberrant ATM function based on the results of a novel flow\ncytometry assay. The fusions were experimentally validated by several\northogonal methods and shown to be maternally inherited, equating to\ncompound heterozygous loss of ATM function which was classified as\ndiagnostic of the patient phenotype. These reciprocal fusions were the only\nmembers of our validation panel that were detected by standard TopHat filters." + }, + { + "id": 136091, + "strid": "09af69c5-7ace-4f02-9786-9550e7c7b124", + "image_id": 205777, + "image_name": "15898.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2965.899, + 670.853, + 489.8359999999998, + 94.41200000000003 + ], + "priority": 11, + "parents": [ + 136103 + ], + "children": [ + 136100 + ], + "area": 1989682.2418469999, + "iscrowd": 0, + "segmentation": [], + "text": "All fusions selected for\nvalidation" + }, + { + "id": 136100, + "strid": "44203d24-81ff-4c12-93d4-800ba0b48728", + "image_id": 205777, + "image_name": "15898.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 2890.519, + 780.377, + 646.433, + 1394.667 + ], + "priority": 12, + "parents": [ + 136091 + ], + "children": [], + "area": 2255694.5456629996, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 136093, + "strid": "7f61820b-0239-44e1-a34e-54f93eaadfc7", + "image_id": 205777, + "image_name": "15898.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3077.087, + 2267.092, + 266.07400000000007, + 42.18199999999979 + ], + "priority": 13, + "parents": [ + 136103 + ], + "children": [ + 136098 + ], + "area": 6976039.3210040005, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 136098, + "strid": "76e3af3e-a985-4404-9199-dc851b5e635c", + "image_id": 205777, + "image_name": "15898.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2915.693, + 2372.403, + 585.7049999999999, + 660.933 + ], + "priority": 14, + "parents": [ + 136093 + ], + "children": [], + "area": 6917198.820279, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 136094, + "strid": "9d80b63f-96ab-4c46-a737-e3f7cabe38ce", + "image_id": 205777, + "image_name": "15898.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 3104.583, + 3104.382, + 213.76899999999978, + 43.014000000000124 + ], + "priority": 15, + "parents": [ + 136103 + ], + "children": [ + 136099 + ], + "area": 9637811.582706, + "iscrowd": 0, + "segmentation": [], + "text": "Reference" + }, + { + "id": 136099, + "strid": "9a7cba1c-6805-4887-b99a-83acce386252", + "image_id": 205777, + "image_name": "15898.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2912.958, + 3216.115, + 596.8510000000001, + 245.95299999999997 + ], + "priority": 16, + "parents": [ + 136094 + ], + "children": [], + "area": 9368407.91817, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 199803, + "strid": "72bca0b4-35d1-444c-87df-db25541ef5a6", + "image_id": 208320, + "image_name": "9932.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 18.09, + 11.54, + 152.03, + 109.46000000000001 + ], + "priority": -1, + "parents": [], + "children": [ + 199783, + 199794, + 199793, + 199796, + 199795, + 199797, + 199784, + 199785, + 199798 + ], + "area": 208.75859999999997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 199783, + "strid": "27b178ec-aeb5-417e-92a1-8abea852e5fe", + "image_id": 208320, + "image_name": "9932.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 34.478, + 34.084, + 1590.588, + 454.454 + ], + "priority": 1, + "parents": [ + 199803 + ], + "children": [], + "area": 1175.1481520000002, + "iscrowd": 0, + "segmentation": [], + "text": "Identifying Unvaccinated\nIndividuals in Canada:\nA Predictive Model" + }, + { + "id": 199784, + "strid": "6018e831-12d9-4103-83c2-49f8cd0baf3c", + "image_id": 208320, + "image_name": "9932.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 166.269, + 558.978, + 1390.628, + 288.578 + ], + "priority": 2, + "parents": [ + 199803 + ], + "children": [], + "area": 92940.713082, + "iscrowd": 0, + "segmentation": [], + "text": "Kevin Dick Ardyn Nordstrom\nSystems and Computer Department of\nEngineering Economics\nkevin.dick @carleton.ca ardyn.nordstrom @carleton.ca" + }, + { + "id": 199785, + "strid": "743b1771-81f8-4a3d-9ccb-4295c8eb8e87", + "image_id": 208320, + "image_name": "9932.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 50.384, + 961.17, + 1117.956, + 327.207 + ], + "priority": 3, + "parents": [ + 199803 + ], + "children": [], + "area": 48427.58928, + "iscrowd": 0, + "segmentation": [], + "text": "Research Question:\n\nWhat is the probability that members of\nCanadian households will have received\ntheir flu vaccination in the past year?" + }, + { + "id": 199795, + "strid": "161d5208-090d-4f1a-8e85-fbf959fcdca1", + "image_id": 208320, + "image_name": "9932.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2033.752, + 20.89, + 938.0750000000003, + 133.726 + ], + "priority": 4, + "parents": [ + 199803 + ], + "children": [ + 199789 + ], + "area": 42485.07928, + "iscrowd": 0, + "segmentation": [], + "text": "| - Introduction" + }, + { + "id": 199789, + "strid": "6d150bb2-11fa-4c46-8e86-d954cc03be96", + "image_id": 208320, + "image_name": "9932.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2032.076, + 165.562, + 2710.9970000000003, + 396.298 + ], + "priority": 5, + "parents": [ + 199795 + ], + "children": [], + "area": 336434.566712, + "iscrowd": 0, + "segmentation": [], + "text": "The Childhood National Immunization Coverage Survey in 2013 found that as many as 23% of Canadian children\ndo not have their basic immunizations (e.g. whooping cough) [3]. More than two thirds of Canadians do not get\ntheir flu shot each year [4]. This is particularly dangerous for seniors as the flu can lead to more serious health\nproblems. Vaccinations have numerous health benefits for immunized individuals as well as for the public through\nherd immunity. In light of this, the Canadian government's latest budget allocated an additional $25\n\nmillion to support vaccination efforts [1]." + }, + { + "id": 199796, + "strid": "579b0c60-7a65-4467-b742-bbb3e22f09ed", + "image_id": 208320, + "image_name": "9932.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 4245.54, + 782.921, + 498.5079999999998, + 134.14999999999998 + ], + "priority": 6, + "parents": [ + 199803 + ], + "children": [ + 199792, + 199791 + ], + "area": 3323922.42234, + "iscrowd": 0, + "segmentation": [], + "text": "ll - Data" + }, + { + "id": 199791, + "strid": "c9506a68-330c-47f7-8c84-259f0c8373c5", + "image_id": 208320, + "image_name": "9932.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2577.918, + 1010.492, + 1028.6889999999999, + 570.03 + ], + "priority": 7, + "parents": [ + 199796 + ], + "children": [], + "area": 2604965.515656, + "iscrowd": 0, + "segmentation": [], + "text": "SS.\n\nVariable\n\nMarginal Effect on\nVaccination\n\n \n\nDiabetic\n\nHaving a young child (age 0-5)\nGets regular checkup\nAsthmatic\n\nRegular smoker\n\nExcellent health (perceived)\nUniversity degree\n\n \n\n12% more likely\n11% more likely\n9% more likely\n9% more likely\n7% less likely\n\n3% less likely\n2% more likely" + }, + { + "id": 199792, + "strid": "84d9ac2c-5ba7-4638-96a8-ea01c238c81c", + "image_id": 208320, + "image_name": "9932.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 3692.593, + 984.798, + 1082.812, + 700.942 + ], + "priority": 8, + "parents": [ + 199796 + ], + "children": [], + "area": 3636458.2012139997, + "iscrowd": 0, + "segmentation": [], + "text": "Using the Canadian Community Health\nSurveys (2009 — 2014), 47 variables out of\n1,381 were identified as being intrinsically\nand statistically significant in predicting\nvaccination outcomes. The marginal effect\nfrom a probit model were used to infer the\nsignificance of each variable.\n\nDiscrete characteristics (e.g. province of\nresidence) were turned into binary variables\nfor intuitive use in the model." + }, + { + "id": 199797, + "strid": "ecd777b6-1818-4454-81cc-4f3812637e8a", + "image_id": 208320, + "image_name": "9932.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1960.944, + 1831.146, + 1445.208, + 149.84400000000005 + ], + "priority": 9, + "parents": [ + 199803 + ], + "children": [ + 199801 + ], + "area": 3590774.7618239997, + "iscrowd": 0, + "segmentation": [], + "text": "lll - Methodology - Model" + }, + { + "id": 199801, + "strid": "1cf2bfa9-eb09-417c-b7a5-71dc4eaeb430", + "image_id": 208320, + "image_name": "9932.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2058.396, + 1957.736, + 2643.9059999999995, + 997.7009999999998 + ], + "priority": 10, + "parents": [ + 199797 + ], + "children": [], + "area": 4029795.9514560006, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 199793, + "strid": "6464da24-97d1-4a4c-8887-3905abc94e7a", + "image_id": 208320, + "image_name": "9932.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 46.885, + 1409.774, + 728.143, + 128.85699999999997 + ], + "priority": 11, + "parents": [ + 199803 + ], + "children": [ + 199786, + 199802, + 199787, + 199790 + ], + "area": 66097.25399, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 199786, + "strid": "c63a5a9f-f10c-449d-85f8-bbe5409b8ba2", + "image_id": 208320, + "image_name": "9932.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 23.116, + 1595.133, + 1865.533, + 583.9729999999997 + ], + "priority": 12, + "parents": [ + 199793 + ], + "children": [], + "area": 36873.094428000004, + "iscrowd": 0, + "segmentation": [], + "text": "Our method has successfully identified individuals over the age\n60 who have not been vaccinated within the last year (negative\npredictive value ~80%).\n\nOur method can accurately identify individuals under the age of 60 who have\nreceived their vaccination in the last year (positive predictive value ~96%).\n\nThe division of age groups at 60 years old was found to greatly increase our\naccuracy (overall accuracy ~70%). From this model’s results, two policies can\nbe developed to increase vaccination rates across all age-groups." + }, + { + "id": 199802, + "strid": "09b1988c-7f19-4588-8e09-8805606dcecc", + "image_id": 208320, + "image_name": "9932.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 874.523, + 218.523, + 2050.894, + 2045.3730000000003 + ], + "priority": 13, + "parents": [ + 199793 + ], + "children": [ + 199800, + 199799 + ], + "area": 191103.389529, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 199799, + "strid": "74f87316-3a41-48fb-8d68-a60a8ae4e212", + "image_id": 208320, + "image_name": "9932.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 89.885, + 2203.084, + 802.348, + 264.58600000000024 + ], + "priority": 14, + "parents": [ + 199802 + ], + "children": [], + "area": 198024.20534, + "iscrowd": 0, + "segmentation": [], + "text": "Policy 1: For high risk individuals\n(60+), this model can be used to\ntarget specific persons who likely\nhave not received their flu shot." + }, + { + "id": 199800, + "strid": "6f2bc18a-b91b-42e1-99b4-fce02aeedba4", + "image_id": 208320, + "image_name": "9932.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1019.371, + 2204.802, + 805.784, + 393.442 + ], + "priority": 15, + "parents": [ + 199802 + ], + "children": [], + "area": 2247511.219542, + "iscrowd": 0, + "segmentation": [], + "text": "Policy 2: For all remaining\nindividuals, this model targets\npersons who are likely to get their\nflu shot, therefore herd immunity\ncan be established by promoting\nflu vaccination in non-targets." + }, + { + "id": 199790, + "strid": "fa43a7da-4686-46ad-b29a-8d631b72c0a2", + "image_id": 208320, + "image_name": "9932.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2278.53, + 605.236, + 1232.2710000000002, + 134.07100000000003 + ], + "priority": 16, + "parents": [ + 199793 + ], + "children": [], + "area": 1379048.38308, + "iscrowd": 0, + "segmentation": [], + "text": "This model can be used to identify individuals at\nrisk of not getting a flu shot." + }, + { + "id": 199787, + "strid": "e2f4a962-1e31-406d-a5d2-286c862f0a87", + "image_id": 208320, + "image_name": "9932.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 42.62, + 2664.99, + 1825.404, + 456.76200000000017 + ], + "priority": 17, + "parents": [ + 199793 + ], + "children": [], + "area": 113581.87379999999, + "iscrowd": 0, + "segmentation": [], + "text": "The final classification model incorporates a decision node to segregate by\nage 60 and then classifies on an “expert” Random Forest trained over that\nage group. Our method is applicable to survey data in future years given its\nperformance over the recently released 2014 dataset (released March 16\",\n2016). Leveraging data from previous years (2009 - 2013), our classifier\nimproved with incorporation of new data, indicating that our method is\nexpected to improve with subsequent data." + }, + { + "id": 199794, + "strid": "03dd1f26-bae8-4e02-976b-30b724962101", + "image_id": 208320, + "image_name": "9932.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 284.092, + 3151.508, + 1349.781, + 152.36799999999994 + ], + "priority": 18, + "parents": [ + 199803 + ], + "children": [ + 199788 + ], + "area": 895318.2107359999, + "iscrowd": 0, + "segmentation": [], + "text": "V - Future Applications" + }, + { + "id": 199788, + "strid": "c63b69d3-324e-425f-9f57-74c45904eb72", + "image_id": 208320, + "image_name": "9932.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 220.994, + 3350.454, + 1485.048, + 196.02599999999984 + ], + "priority": 19, + "parents": [ + 199794 + ], + "children": [], + "area": 740430.231276, + "iscrowd": 0, + "segmentation": [], + "text": "Given the Canadian government’s recent budget allocating\n$25 million dollars to supporting vaccination efforts, our\nmodel can be used to efficiently deploy these resources." + }, + { + "id": 199798, + "strid": "967664ba-d681-41ae-8f8d-1fc44bcb2371", + "image_id": 208320, + "image_name": "9932.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1980.57, + 3070.949, + 2665.005, + 486.20199999999977 + ], + "priority": 20, + "parents": [ + 199803 + ], + "children": [], + "area": 6082229.46093, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 160092, + "strid": "c9085ac9-fac9-42ce-a738-1d8574ab495d", + "image_id": 206752, + "image_name": "6369.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 59.37, + 60.69, + 109.46000000000001, + 103.39000000000001 + ], + "priority": -1, + "parents": [], + "children": [ + 160074, + 160072, + 160075, + 160073, + 160070, + 160076, + 160077, + 160078, + 160071 + ], + "area": 3603.1652999999997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 160070, + "strid": "b463d943-892b-424c-a705-6fa235694e0d", + "image_id": 206752, + "image_name": "6369.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 672.578, + 27.276, + 2163.889, + 230.12099999999998 + ], + "priority": 1, + "parents": [ + 160092 + ], + "children": [], + "area": 18345.237527999998, + "iscrowd": 0, + "segmentation": [], + "text": "The TOPCONS webserver for consensus prediction\nof membrane protein topology and signal peptides" + }, + { + "id": 160071, + "strid": "979ca983-f929-4295-908f-4e34db5d78bd", + "image_id": 206752, + "image_name": "6369.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 551.774, + 389.312, + 2514.206, + 283.115 + ], + "priority": 2, + "parents": [ + 160092 + ], + "children": [], + "area": 214812.23948800002, + "iscrowd": 0, + "segmentation": [], + "text": "Konstantinos D. Tsirigost, Christoph Peters, Nanjiang Shu?2, Lukas Kall* and Arne Elofsson?\n1Department of Biochemistry and Biophysics, Stockholm University & Science for Life Laboratory, Stockholm, Sweden.\nBioinformatics Infrastructure for Life Sciences (BILS), Stockholm University, Sweden.\n\n*E-mail: kostas.tsirigos@scilifelab.se" + }, + { + "id": 160078, + "strid": "5dff0146-6aa0-4ba8-8edb-f66a51badf9e", + "image_id": 206752, + "image_name": "6369.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 189.803, + 757.912, + 1611.476, + 155.087 + ], + "priority": 3, + "parents": [ + 160092 + ], + "children": [], + "area": 143853.97133600002, + "iscrowd": 0, + "segmentation": [], + "text": "In the updated version of the TOPCONS web server, we use a different combination\nof topology prediction methods to improve its performance and to be able to predict\nthe presence of a signal peptide in the protein sequence." + }, + { + "id": 160072, + "strid": "6d61649a-89d2-400c-a84a-15566d55dfbc", + "image_id": 206752, + "image_name": "6369.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 444.699, + 1022.632, + 1105.926, + 55.149 + ], + "priority": 4, + "parents": [ + 160092 + ], + "children": [ + 160079, + 160087, + 160081, + 160088, + 160082, + 160080, + 160089, + 160086 + ], + "area": 454763.427768, + "iscrowd": 0, + "segmentation": [], + "text": "a-helical membrane proteins topology prediction" + }, + { + "id": 160079, + "strid": "35ed0f3a-8f6c-4a4a-87c7-6965dacd14d3", + "image_id": 206752, + "image_name": "6369.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 170.194, + 1116.216, + 1652.476, + 222.82600000000002 + ], + "priority": 5, + "parents": [ + 160072 + ], + "children": [], + "area": 189973.26590399997, + "iscrowd": 0, + "segmentation": [], + "text": "a-helical transmembrane proteins constitute approximately 20-30% of fully sequenced proteomes and\nform an important class of proteins since they are crucial for a wide variety of cellular functions’. In\norder to understand their role, we must acquire information about their structure and topology across\nthe membrane. During the last few decades, a large number of computational methods has been\ndeveloped for transmembrane protein structure and topology prediction." + }, + { + "id": 160087, + "strid": "34edeca3-4ddd-49a3-bd25-d1ec581cb850", + "image_id": 206752, + "image_name": "6369.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 354.468, + 1420.035, + 1287.907, + 454.72500000000014 + ], + "priority": 6, + "parents": [ + 160072 + ], + "children": [], + "area": 503356.96638000006, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 160086, + "strid": "f785474e-65a2-4d1e-be46-68b4c93d008f", + "image_id": 206752, + "image_name": "6369.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 170.227, + 1962.977, + 1649.956, + 347.711 + ], + "priority": 7, + "parents": [ + 160072 + ], + "children": [], + "area": 334151.68577900005, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 160080, + "strid": "61a64a98-0b37-4821-abbb-4244950c26dc", + "image_id": 206752, + "image_name": "6369.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 170.121, + 2374.093, + 1652.246, + 224.3420000000001 + ], + "priority": 8, + "parents": [ + 160072 + ], + "children": [], + "area": 403883.075253, + "iscrowd": 0, + "segmentation": [], + "text": "The table above shows the prediction performance of TOPCONS against other available topology\nprediction methods that can be used for scanning entire proteomes. TOPCONS shows an 4% overall\nincrease in performance (and 9% in TM proteins only), using 4 different datasets (with ~7,000\nproteins in total), namely only TM-proteins, TM-proteins with a signal peptide, globular proteins and\nglobular proteins with a signal peptide." + }, + { + "id": 160088, + "strid": "5e8d4c73-841a-42c8-a27c-ad059017d0e2", + "image_id": 206752, + "image_name": "6369.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 394.747, + 2646.499, + 1113.513, + 821.8789999999999 + ], + "priority": 9, + "parents": [ + 160072 + ], + "children": [], + "area": 1044697.540753, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 160081, + "strid": "605f728a-ce37-42bd-a5d1-1b399c322133", + "image_id": 206752, + "image_name": "6369.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 226.521, + 3512.252, + 1577.447, + 133.5 + ], + "priority": 10, + "parents": [ + 160072 + ], + "children": [], + "area": 795598.835292, + "iscrowd": 0, + "segmentation": [], + "text": "TOPCONS is unique amongst the available topology prediction methods in that it can predict the\npresence of a signal peptide and, at the same time, maintain a state-of-art performance in\nmembrane protein topology prediction." + }, + { + "id": 160089, + "strid": "b64c3913-1168-4be9-bf4a-0a6c5d78d994", + "image_id": 206752, + "image_name": "6369.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 178.862, + 3671.735, + 678.829, + 541.8979999999997 + ], + "priority": 11, + "parents": [ + 160072 + ], + "children": [], + "area": 656733.86557, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 160082, + "strid": "9ef75735-b157-428e-beb0-c30ee9a9c0f2", + "image_id": 206752, + "image_name": "6369.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 990.692, + 3736.287, + 773.3780000000002, + 434.25800000000027 + ], + "priority": 12, + "parents": [ + 160072 + ], + "children": [], + "area": 3701509.6406039996, + "iscrowd": 0, + "segmentation": [], + "text": "Shortening the process time\n\nOne of the main reasons that TOPCONS is\nideal for proteome-wide analyses is the usage\nof a large protein database for the construction\nof MSA, which is combined with an efficient\nstrategy that shortens the creation of the\nprofile. The graph on the left illustrates the\naverage time that a protein needs to be\nprocessed." + }, + { + "id": 160073, + "strid": "4cd307d6-e55c-4aea-b5c9-7ab99ac408c7", + "image_id": 206752, + "image_name": "6369.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2441.851, + 769.612, + 458.93499999999995, + 43.87199999999996 + ], + "priority": 13, + "parents": [ + 160092 + ], + "children": [ + 160090 + ], + "area": 1879277.831812, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 160090, + "strid": "df1bd6f9-4002-4ee9-bed6-7eaf27b72358", + "image_id": 206752, + "image_name": "6369.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2158.014, + 893.245, + 1064.2039999999997, + 1130.563 + ], + "priority": 14, + "parents": [ + 160073 + ], + "children": [], + "area": 1927635.21543, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 160074, + "strid": "b4497317-19b3-4fa8-98f0-f6d14fea794e", + "image_id": 206752, + "image_name": "6369.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2321.308, + 2149.789, + 706.9319999999998, + 52.77300000000014 + ], + "priority": 15, + "parents": [ + 160092 + ], + "children": [ + 160091 + ], + "area": 4990322.404012, + "iscrowd": 0, + "segmentation": [], + "text": "Using the TOPCONS web server" + }, + { + "id": 160091, + "strid": "d4b834c5-1c61-4fa7-91eb-ddb4982f9708", + "image_id": 206752, + "image_name": "6369.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2024.243, + 2211.16, + 1302.02, + 1399.649 + ], + "priority": 16, + "parents": [ + 160074 + ], + "children": [], + "area": 4475925.15188, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 160075, + "strid": "6c795f9e-5484-449c-a363-7a0812c2d048", + "image_id": 206752, + "image_name": "6369.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2539.891, + 3728.867, + 267.17999999999984, + 43.45699999999988 + ], + "priority": 17, + "parents": [ + 160092 + ], + "children": [ + 160085 + ], + "area": 9470915.733497001, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 160085, + "strid": "95d04e8b-d2a2-4210-b73a-eb4e59fede70", + "image_id": 206752, + "image_name": "6369.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2028.926, + 3790.347, + 1301.1399999999999, + 440.8340000000003 + ], + "priority": 18, + "parents": [ + 160075 + ], + "children": [], + "area": 7690333.577322, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 160077, + "strid": "e59058b3-e980-4265-b1b2-b2ba10615f8b", + "image_id": 206752, + "image_name": "6369.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1976.992, + 4301.179, + 181.7969999999998, + 48.5649999999996 + ], + "priority": 19, + "parents": [ + 160092 + ], + "children": [ + 160084 + ], + "area": 8503396.473568, + "iscrowd": 0, + "segmentation": [], + "text": "Funding" + }, + { + "id": 160084, + "strid": "f9684b3f-13b7-4fff-bb24-c261e74ba820", + "image_id": 206752, + "image_name": "6369.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1974.814, + 4353.775, + 936.6809999999998, + 102.77099999999973 + ], + "priority": 20, + "parents": [ + 160077 + ], + "children": [], + "area": 8597895.82285, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 160076, + "strid": "12bcc215-7505-44b6-a8f0-ba55b19253be", + "image_id": 206752, + "image_name": "6369.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 116.921, + 4300.684, + 248.858, + 49.05199999999968 + ], + "priority": 21, + "parents": [ + 160092 + ], + "children": [ + 160083 + ], + "area": 502840.27396400005, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 160083, + "strid": "498c81eb-afc1-4370-a23d-45254c0fb29a", + "image_id": 206752, + "image_name": "6369.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 113.394, + 4354.362, + 1477.157, + 65.77300000000014 + ], + "priority": 22, + "parents": [ + 160076 + ], + "children": [], + "area": 493758.52462800004, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 171524, + "strid": "c71e3c30-220d-425e-a8cb-948d06a9cd2e", + "image_id": 207191, + "image_name": "7081.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 40.47, + 35.84, + 108.56, + 108.56 + ], + "priority": -1, + "parents": [], + "children": [ + 171504, + 171499, + 171498, + 171502, + 171503, + 171501, + 171500 + ], + "area": 1450.4448, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 171498, + "strid": "1a0a9d2e-a60e-4c67-bc47-891a29860f3c", + "image_id": 207191, + "image_name": "7081.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 223.921, + 171.683, + 2869.675, + 168.75 + ], + "priority": 1, + "parents": [ + 171524 + ], + "children": [], + "area": 38443.429043, + "iscrowd": 0, + "segmentation": [], + "text": "Letters in the forest: global precedence effect disappears for letters but not for non-letters under\n\nreading-like conditions" + }, + { + "id": 171499, + "strid": "85a2d235-8945-4e76-bcfa-4c734fca3c52", + "image_id": 207191, + "image_name": "7081.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 950.717, + 380.855, + 940.9040000000001, + 222.68499999999995 + ], + "priority": 2, + "parents": [ + 171524 + ], + "children": [], + "area": 362085.323035, + "iscrowd": 0, + "segmentation": [], + "text": "Andreas Schmitt & Thomas Lachmann\nCenter for Cognitive Science,\n\nCognitive and Developmental Psychology Unit,\nUniversity of Kaiserslautern, Kaiserslautern, Germany" + }, + { + "id": 171500, + "strid": "3eddcb0d-54cc-4070-beb7-ba41a96f93dc", + "image_id": 207191, + "image_name": "7081.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 698.622, + 718.8, + 293.852, + 52.662000000000035 + ], + "priority": 3, + "parents": [ + 171524 + ], + "children": [ + 171505, + 171518 + ], + "area": 502169.4935999999, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 171505, + "strid": "6fee17c3-4ffb-4a02-b5db-0e1fefd15250", + "image_id": 207191, + "image_name": "7081.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 80.671, + 810.793, + 1534.689, + 442.47300000000007 + ], + "priority": 4, + "parents": [ + 171500 + ], + "children": [], + "area": 65407.48210300001, + "iscrowd": 0, + "segmentation": [], + "text": "Several authors have proposed that in acquiring a normal-level of reading ability, visual\nprocessing of letters (more precisely graphemes), is singled out from that of similar non-\nletter shapes (Lachmann and van Leeuwen, 2004, 2008; Fernandes et al., 2014).\n\nWe think experienced readers use an analytical processing strategy for reading letters,\nwhereas for non-letter shapes a holistic strategy is preferred.\n\nApparently, this preference for analytic letter processing in normal readers is in conflict with\nthe global precedence effect (GPE): “forest before trees,” to use a common metaphor (Navon,\n1977).\n\nThe GPE implies for composed hierarchical letters" + }, + { + "id": 171518, + "strid": "01a7743e-cc94-4f74-a6eb-768a67534732", + "image_id": 207191, + "image_name": "7081.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 83.932, + 1267.001, + 1529.028, + 547.1870000000001 + ], + "priority": 5, + "parents": [ + 171500 + ], + "children": [], + "area": 106341.927932, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 171501, + "strid": "57b57fae-72bf-418e-bf4c-1912f2bf3317", + "image_id": 207191, + "image_name": "7081.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 735.036, + 1879.221, + 224.34500000000003, + 58.5920000000001 + ], + "priority": 6, + "parents": [ + 171524 + ], + "children": [ + 171509, + 171522, + 171510, + 171508, + 171506, + 171521, + 171507, + 171523 + ], + "area": 1381295.086956, + "iscrowd": 0, + "segmentation": [], + "text": "Paradigm" + }, + { + "id": 171506, + "strid": "8139f03a-db89-4d9d-b91a-99ad76671383", + "image_id": 207191, + "image_name": "7081.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 84.664, + 1987.087, + 1529.59, + 92.63799999999992 + ], + "priority": 7, + "parents": [ + 171501 + ], + "children": [], + "area": 168234.733768, + "iscrowd": 0, + "segmentation": [], + "text": "Participants: Thirty-seven participants (16 female, mean age: 26 years; SD: 3, german native\nspeakers, normal or corrected-to normal vision)" + }, + { + "id": 171507, + "strid": "dea0110e-2e9f-476a-a431-8a2912d31b91", + "image_id": 207191, + "image_name": "7081.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 83.107, + 2135.064, + 1530.086, + 193.5630000000001 + ], + "priority": 8, + "parents": [ + 171501 + ], + "children": [], + "area": 177438.76384799997, + "iscrowd": 0, + "segmentation": [], + "text": "Material: Compound, hierarchical letter and non-letter stimuli (visual angle: 6.5° for global\nlevel and 0.5° for local level, see Figure 1), either congruent (e.g., a C of Cs) or incongruent\n(e.g., a C of Fs) were used. Stimuli were presented in black (0.4 cd/m?) against a white\nbackground (28.9 cd/m?) in a test cubicle with sound attenuation and controlled lighting." + }, + { + "id": 171521, + "strid": "9f8107d0-8460-48d7-a995-c71c6cf7eef7", + "image_id": 207191, + "image_name": "7081.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 96.913, + 2393.682, + 1302.424, + 632.8580000000002 + ], + "priority": 9, + "parents": [ + 171501 + ], + "children": [ + 171515 + ], + "area": 231978.90366599997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 171515, + "strid": "eb7930cf-5fdb-467e-8aa0-5f92a4842257", + "image_id": 207191, + "image_name": "7081.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 85.751, + 3061.758, + 802.386, + 36.00500000000011 + ], + "priority": 10, + "parents": [ + 171521 + ], + "children": [], + "area": 262548.810258, + "iscrowd": 0, + "segmentation": [], + "text": "FIGURE 1 | Hierarchical stimuli used in the experiment" + }, + { + "id": 171508, + "strid": "c0428832-d8d4-45f9-a81a-b9c6c6e881c8", + "image_id": 207191, + "image_name": "7081.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 83.642, + 3144.047, + 1524.33, + 191.76600000000008 + ], + "priority": 11, + "parents": [ + 171501 + ], + "children": [], + "area": 262974.379174, + "iscrowd": 0, + "segmentation": [], + "text": "Procedure: In each of four blocks (either with letters or non-letters) participants were asked\nto respond either to the identity of the local elements and to ignore the global shape or vice\nversa (two-alternative-forced-choice identification task). Participants responded by pressing\neither the left or the right key of the embedded laptop mouse (see Figure 2)." + }, + { + "id": 171509, + "strid": "cf92546b-b5a5-4098-8292-6efb62c3820e", + "image_id": 207191, + "image_name": "7081.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 98.82, + 3396.713, + 345.195, + 47.86299999999983 + ], + "priority": 12, + "parents": [ + 171501 + ], + "children": [], + "area": 335663.17866, + "iscrowd": 0, + "segmentation": [], + "text": "Global letter task" + }, + { + "id": 171522, + "strid": "a59e26c8-a7c1-460a-af63-acca35a00ca5", + "image_id": 207191, + "image_name": "7081.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 78.874, + 3462.664, + 1505.5, + 431.799 + ], + "priority": 13, + "parents": [ + 171501 + ], + "children": [ + 171516 + ], + "area": 273114.160336, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 171516, + "strid": "91469204-0f50-44bf-8656-5b3ffa273560", + "image_id": 207191, + "image_name": "7081.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 82.65, + 4457.664, + 665.502, + 31.92199999999957 + ], + "priority": 14, + "parents": [ + 171522 + ], + "children": [], + "area": 368425.92960000003, + "iscrowd": 0, + "segmentation": [], + "text": "FIGURE 2 | Illustration of the two letter tasks" + }, + { + "id": 171510, + "strid": "c0947201-55ad-4e90-9d8e-e5ab2ffbbd15", + "image_id": 207191, + "image_name": "7081.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 104.123, + 3927.484, + 324.613, + 46.195000000000164 + ], + "priority": 15, + "parents": [ + 171501 + ], + "children": [], + "area": 408941.416532, + "iscrowd": 0, + "segmentation": [], + "text": "Local letter task" + }, + { + "id": 171523, + "strid": "91f71a66-c52c-487c-a663-15d8423c6ac4", + "image_id": 207191, + "image_name": "7081.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 85.773, + 4006.759, + 1516.537, + 379.0559999999996 + ], + "priority": 16, + "parents": [ + 171501 + ], + "children": [], + "area": 343671.739707, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 171502, + "strid": "fc6867cb-cdfd-4790-828f-484debdbf033", + "image_id": 207191, + "image_name": "7081.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2377.72, + 722.011, + 173.8090000000002, + 46.611999999999966 + ], + "priority": 17, + "parents": [ + 171524 + ], + "children": [ + 171511, + 171512, + 171519, + 171520 + ], + "area": 1716739.9949199997, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 171520, + "strid": "e442de0d-d0d6-4c09-b3e7-461668140977", + "image_id": 207191, + "image_name": "7081.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1692.78, + 797.003, + 1457.5089999999998, + 1055.0059999999999 + ], + "priority": 18, + "parents": [ + 171502 + ], + "children": [ + 171517 + ], + "area": 1349150.7383400002, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 171517, + "strid": "bb548000-d953-40bc-9892-83a0d5998254", + "image_id": 207191, + "image_name": "7081.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1698.672, + 1874.441, + 1530.973, + 86.875 + ], + "priority": 19, + "parents": [ + 171520 + ], + "children": [], + "area": 3184060.442352, + "iscrowd": 0, + "segmentation": [], + "text": "FIGURE 3 | Mean RT for letter stimuli (left side) and non-letter stimuli (right side) for congruent and\nincongruent trials in the local and global trial blocks." + }, + { + "id": 171511, + "strid": "3df34f4a-bf07-47ff-8f96-374ef9703121", + "image_id": 207191, + "image_name": "7081.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1702.586, + 1983.793, + 1526.7190000000003, + 144.62400000000002 + ], + "priority": 20, + "parents": [ + 171502 + ], + "children": [], + "area": 3377578.188698, + "iscrowd": 0, + "segmentation": [], + "text": "Mean Reaction times (RT, Figure 3) of correct responses within a range of 200-2000 ms\nwere analyzed in a 2 (Material: letters or shapes) X 2 (Level: global or local) X 2\n(Congruency: congruent or incongruent) repeated-measures ANOVA." + }, + { + "id": 171519, + "strid": "a5564f22-477c-41c1-bbd8-83fbcc237493", + "image_id": 207191, + "image_name": "7081.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1702.028, + 2135.013, + 1526.1269999999997, + 391.40700000000015 + ], + "priority": 21, + "parents": [ + 171502 + ], + "children": [], + "area": 3633851.906364, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 171512, + "strid": "b34670e5-e129-466e-be1f-f99902e2bff8", + "image_id": 207191, + "image_name": "7081.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1703.118, + 2535.595, + 1526.188, + 91.4960000000001 + ], + "priority": 22, + "parents": [ + 171502 + ], + "children": [], + "area": 4318417.48521, + "iscrowd": 0, + "segmentation": [], + "text": "For non-letters we observed a global advantage and an asymmetric congruence, whereas\nfor letters there was only a both sided congruence effect, independent of the target level." + }, + { + "id": 171503, + "strid": "1c805291-b66b-4d8e-85b6-317fe4f40d68", + "image_id": 207191, + "image_name": "7081.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2339.168, + 2698.203, + 248.22699999999986, + 45.565000000000055 + ], + "priority": 23, + "parents": [ + 171524 + ], + "children": [ + 171513 + ], + "area": 6311550.115104, + "iscrowd": 0, + "segmentation": [], + "text": "Discussion" + }, + { + "id": 171513, + "strid": "673d3627-5e66-44a2-8e70-0407d5d3b849", + "image_id": 207191, + "image_name": "7081.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1702.572, + 2794.23, + 1533.1520000000003, + 744.703 + ], + "priority": 24, + "parents": [ + 171503 + ], + "children": [], + "area": 4757377.75956, + "iscrowd": 0, + "segmentation": [], + "text": "In the present study, we could observe a difference in the GPE between letters and non-\nletters: The GPE remained intact for non-letter stimuli but disappeared for letters; for\nletters there was no general advantage for global stimuli (i.e., no global advantage effect)\nand the congruence effect was independent of level (i.e, no asymmetric congruence effect).\nFor the local level we imposed a scale of stimuli close to the critical threshold for fluent\nreading (Jordan and Martin, 1987). For the global level, we expected it to fall within the\nfunctional visual field (Sanders, 1970).\n\nSince the “forest before tree” effect vanished only for letters, we assume that a letter-\nspecific strategy is applied to these stimuli. The emergence of a letter-specific strategy is in\naccordance with earlier studies, in which skilled readers used a specific processing strategy\nfor encoding letters (Lachmann and van Leeuwen, 2004, 2008), while illiterates did not\n(Fernandes et al., 2014). This letter-specific processing strategy was described as more\nanalytic than for non-letter shapes, for which processing is holistic. Consequently, the\nresults suggest that this differentiation can be extended to compound figures, as long as\nthe stimulus dimensions invite a reading-specific strategy." + }, + { + "id": 171504, + "strid": "a5cee5eb-1843-4477-aea0-e466e3cf8eaa", + "image_id": 207191, + "image_name": "7081.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2337.123, + 3620.16, + 256.41100000000006, + 44.490999999999985 + ], + "priority": 25, + "parents": [ + 171524 + ], + "children": [ + 171514 + ], + "area": 8460759.19968, + "iscrowd": 0, + "segmentation": [], + "text": "References" + }, + { + "id": 171514, + "strid": "26c786ae-fc4f-4e38-9983-cb9c77d1db6a", + "image_id": 207191, + "image_name": "7081.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1696.659, + 3698.984, + 1539.116, + 604.422 + ], + "priority": 26, + "parents": [ + 171504 + ], + "children": [], + "area": 6275914.494456001, + "iscrowd": 0, + "segmentation": [], + "text": "Amirkhiabani, G., and Lovegrove, W. J. (1996). Role of eccentricity and size in the global precedence effect. J. Exp.\nPsychol. 22, 1434-1447.\n\nFernandes, T., Vale, A. P., Martins, B., Morais, J.,and Kolinsky, R. (2014). The deficit of letter processing in developmental\ndyslexia: combining evidence from dyslexics, typical readers and illiterate adults. Dev. Sci. 17,125-141.\n\nJordan, T., and Martin, C. (1987). The importance of visual angle in word recognition : a «shrinking screen>\nmodification for visual displays. Behav. Res. Methods Instrum. Comput. 19, 307-310.\n\nLachmann, T., and van Leeuwen, C. (2004). Negative congruence effects in letter and pseudo-letter recognition: the\nrole of similarity and response conflict. Cogn. Process. 5, 239-248.\n\nLachmann, T., and van Leeuwen, C. (2008). Differentiation of holistic processing in the time course of letter\nrecognition. Acta Psychol. 129, 121-129.\n\nLamb, M. R.,and Robertson, L. C. (1990). The effect of visual angle on global and global reaction times depend on the\nset of visual angles presented. Percept. Psychophys. 47, 489-496.\n\nNavon, D. (1977). Forest before trees: the precedence of global features in visual perception. Cogn. Psychol. 9, 353-\n383.\n\nSanders, A. F. (1970). Some aspects of the selective process in the functional visual field. Ergonomics 13, 101-117." + }, + { + "id": 157647, + "strid": "96adf910-257f-43a3-b8cc-d9339824141f", + "image_id": 206658, + "image_name": "6202.png", + "category_id": 8, + "category_name": "Unknown", + "bbox": [ + 1700.176, + 584.091, + 1532.77, + 1585.7200000000003 + ], + "priority": -1, + "parents": [], + "children": [], + "area": 993057.500016, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 157648, + "strid": "75260bae-e790-423d-abd1-52b2c0af4880", + "image_id": 206658, + "image_name": "6202.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 9.8, + 14.34, + 73.42, + 102.14999999999999 + ], + "priority": -1, + "parents": [], + "children": [ + 157632, + 157631, + 157627, + 157628, + 157629, + 157630 + ], + "area": 140.532, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 157627, + "strid": "aac0f6db-e191-4ad4-9925-e8d6c05b2b35", + "image_id": 206658, + "image_name": "6202.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 861.54, + 128.916, + 2038.701, + 213.411 + ], + "priority": 1, + "parents": [ + 157648 + ], + "children": [], + "area": 111066.29063999999, + "iscrowd": 0, + "segmentation": [], + "text": "A high-resolution 7T fMRI dataset from\ncomplex natural stimulation with an audio movie" + }, + { + "id": 157628, + "strid": "3f607fa2-9570-496e-abcf-411311cfe02f", + "image_id": 206658, + "image_name": "6202.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 871.583, + 357.391, + 1985.976, + 70.30000000000001 + ], + "priority": 2, + "parents": [ + 157648 + ], + "children": [], + "area": 311495.91995300003, + "iscrowd": 0, + "segmentation": [], + "text": "M. Hanke, F.J. Baumgartner, P. Ibe, F.R. Kaule, S. Pollmann, O. Speck, W. Zinke & Jorg Stadler" + }, + { + "id": 157629, + "strid": "00ca2e1b-9a5c-4fb7-8c55-9e13f1e4e5aa", + "image_id": 206658, + "image_name": "6202.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 703.94, + 565.687, + 319.991, + 87.43899999999996 + ], + "priority": 3, + "parents": [ + 157648 + ], + "children": [ + 157633, + 157643 + ], + "area": 398209.70678000007, + "iscrowd": 0, + "segmentation": [], + "text": "Summary" + }, + { + "id": 157633, + "strid": "374639ec-0e99-4abe-9f14-e77338feb1d3", + "image_id": 206658, + "image_name": "6202.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 67.627, + 647.247, + 1567.365, + 901.91 + ], + "priority": 4, + "parents": [ + 157629 + ], + "children": [], + "area": 43771.37286899999, + "iscrowd": 0, + "segmentation": [], + "text": "Here we present a high-resolution functional magnetic resonance (fMRI)\ndataset: 20 participants recorded at high field strength (7 Tesla) during\nprolonged stimulation with an auditory feature film (\"Forrest Gump\"). In\naddition, a comprehensive set of auxiliary data (T1w, T2w, DTI,\nsusceptibility-weighted image, angiography) as well as measurements to\nassess technical and physiological noise components have been acquired.\nAn initial analysis confirms that these data can be used to study common\nand idiosyncratic brain response patterns to complex auditory\nstimulation. Among the potential uses of this dataset are the study of\nauditory attention and cognition, language and music perception, and\nsocial perception. The auxiliary measurements enable a large variety of\nadditional analysis strategies that relate functional response patterns to\nstructural properties of the brain. Alongside the acquired data, we provide\nsource code and detailed information on all employed procedures --- from\nstimulus creation to data analysis. In order to facilitate replicative and\nderived works, only free and open-source software was utilized." + }, + { + "id": 157643, + "strid": "18b4654c-45f9-4a66-9236-8725b22e6995", + "image_id": 206658, + "image_name": "6202.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 73.471, + 1576.91, + 1555.989, + 1567.0709999999997 + ], + "priority": 5, + "parents": [ + 157629 + ], + "children": [ + 157637 + ], + "area": 115857.15461000001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 157637, + "strid": "8adc5a9c-4f87-4d93-9a24-5a22a66db642", + "image_id": 206658, + "image_name": "6202.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 67.014, + 3161.568, + 1538.969, + 118.75700000000006 + ], + "priority": 6, + "parents": [ + 157643 + ], + "children": [], + "area": 211869.317952, + "iscrowd": 0, + "segmentation": [], + "text": "Data acquisition workflow and relation to data records. Acquisition was split into three imaging sessions and a survey. Physiological measurements were\nrecorded simultaneous with the functional MRI during auditory stimulation. MRI data acquistion at 7T was performed with partial brain coverage. The\nmeasurement field-of-view was automatically aligned across sessions and participants. (7T MRI photo courtesy of the Center for Behavioral Brain\nSciences/D. Mahler; 3T MRI photo courtesy of the Leibniz Institute for Neurobiology/A. Fugner)" + }, + { + "id": 157630, + "strid": "d9f5c176-4dc2-4efa-bc78-4de52cba65d8", + "image_id": 206658, + "image_name": "6202.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 258.446, + 3317.569, + 1208.7200000000003, + 76.26000000000022 + ], + "priority": 7, + "parents": [ + 157648 + ], + "children": [ + 157646 + ], + "area": 857412.4377740001, + "iscrowd": 0, + "segmentation": [], + "text": "Field-of-view and signal-to-noise ratio" + }, + { + "id": 157646, + "strid": "9692e0d5-8521-4f15-9e7d-64e896d5603c", + "image_id": 206658, + "image_name": "6202.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 69.108, + 3409.772, + 1558.557, + 721.5150000000003 + ], + "priority": 8, + "parents": [ + 157630 + ], + "children": [ + 157638 + ], + "area": 235642.523376, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 157638, + "strid": "b3483aa7-4ae9-4f28-abc5-6582c66807c5", + "image_id": 206658, + "image_name": "6202.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 70.501, + 4149.011, + 1549.034, + 212.8729999999996 + ], + "priority": 9, + "parents": [ + 157646 + ], + "children": [], + "area": 292509.42451100005, + "iscrowd": 0, + "segmentation": [], + "text": "(A) Custom T2* EPI group template (in gray), linearly aligned to and overlayed on the MNI152 T1-weighted head template (in amber). The EPI template\nwas created by an iterative procedure with four linear and ten non-linear alignment steps out of one sample volume per run and brain (a total of 152\nimages; images from participant 10 were excluded; slice cut point: anterior commissure at MNI 0,0,0 mm). (B) Intersection masks after linear and non-\nlinear anatomical alignment of all mean volumes for all individual fMRI runs across all participants. The linear intersection mask is depicted in blue, non-\nlinear in yellow (overlap in green). Coordinates are in MNI millimeters. (C) Distribution of the temporal signal-to-noise ratio (tSNR) computed from a\ntemporally de-trended gel phantom dataset. The left side of the panel shows the spatial distribution in arbitrarily selected slices. The right side shows a\ntSNR histogram across all voxels inside the phantom." + }, + { + "id": 157631, + "strid": "c971f9cb-2ad0-49a4-9ea1-d43e87994bc3", + "image_id": 206658, + "image_name": "6202.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2037.121, + 2516.812, + 901.8530000000001, + 78.42399999999998 + ], + "priority": 10, + "parents": [ + 157648 + ], + "children": [ + 157644 + ], + "area": 5127050.578252, + "iscrowd": 0, + "segmentation": [], + "text": "Common response patterns" + }, + { + "id": 157644, + "strid": "9fad2d18-8eee-4624-87ac-51b09d62a0d4", + "image_id": 206658, + "image_name": "6202.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1700.049, + 2609.693, + 1536.435, + 765.3360000000002 + ], + "priority": 11, + "parents": [ + 157631 + ], + "children": [ + 157639 + ], + "area": 4436605.974957, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 157639, + "strid": "3cba0229-1730-4a84-8c48-582279cd8a13", + "image_id": 206658, + "image_name": "6202.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1693.509, + 3383.713, + 1541.531, + 119.10800000000017 + ], + "priority": 12, + "parents": [ + 157644 + ], + "children": [], + "area": 5730348.418917, + "iscrowd": 0, + "segmentation": [], + "text": "Area of maximum inter-individual response similarity. (A) Representative slices of the group EPI template depicting the 95% percentile of univariate inter-\nbrain time-series correlations for linear (blue) and non-linear (yellow) alignment in the group EPI template space. (B) Distribution of percent ranks of\nmean inter-brain correlations on the cortical surface. The statistical map is thresholded at percent rank=50%. The colored outlines depict the 99%\npercentile for linear (blue) and non-linear (green) alignment. (C) Analog to B, depicting the distribution of multivariate 2nd-order pattern consistency." + }, + { + "id": 157632, + "strid": "e86e0ee9-a3d8-4188-b37a-e8782969f251", + "image_id": 206658, + "image_name": "6202.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2200.112, + 3519.027, + 533.797, + 77.69799999999987 + ], + "priority": 13, + "parents": [ + 157648 + ], + "children": [ + 157642, + 157641, + 157645, + 157640 + ], + "area": 7742253.531024001, + "iscrowd": 0, + "segmentation": [], + "text": "Project roadmap" + }, + { + "id": 157645, + "strid": "ff4acdca-2a55-406e-821e-4083bb926bcd", + "image_id": 206658, + "image_name": "6202.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1688.864, + 3568.851, + 1552.1979999999999, + 521.2559999999999 + ], + "priority": 14, + "parents": [ + 157632 + ], + "children": [ + 157635, + 157634, + 157636 + ], + "area": 6027303.975264001, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 157634, + "strid": "362ce109-dd72-4838-a3ac-ae0b4eaa2a3f", + "image_id": 206658, + "image_name": "6202.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1743.823, + 4093.984, + 372.97500000000014, + 51.039000000000215 + ], + "priority": 15, + "parents": [ + 157645 + ], + "children": [], + "area": 7139183.460832001, + "iscrowd": 0, + "segmentation": [], + "text": "Phase 1 (complete)" + }, + { + "id": 157635, + "strid": "6a09e770-cfbf-447b-ab32-029ef84caed8", + "image_id": 206658, + "image_name": "6202.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2272.531, + 4097.91, + 404.384, + 49.72999999999956 + ], + "priority": 16, + "parents": [ + 157645 + ], + "children": [], + "area": 9312627.51021, + "iscrowd": 0, + "segmentation": [], + "text": "Phase 2 (in progress)" + }, + { + "id": 157636, + "strid": "f37d43b9-521a-4769-8b31-96615cd00a5e", + "image_id": 206658, + "image_name": "6202.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2835.266, + 4095.293, + 349.41899999999987, + 51.039000000000215 + ], + "priority": 17, + "parents": [ + 157645 + ], + "children": [], + "area": 11611245.002938, + "iscrowd": 0, + "segmentation": [], + "text": "Phase 3 (planned)" + }, + { + "id": 157640, + "strid": "ebc31a44-1bfd-442e-94df-4829e0878c57", + "image_id": 206658, + "image_name": "6202.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 1689.656, + 4146.495, + 493.2930000000001, + 356.4250000000002 + ], + "priority": 18, + "parents": [ + 157632 + ], + "children": [], + "area": 7006150.155719999, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 157641, + "strid": "5692a21e-ec54-45da-bb28-a68e66120225", + "image_id": 206658, + "image_name": "6202.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2224.294, + 4153.623, + 503.27300000000014, + 392.0680000000002 + ], + "priority": 19, + "parents": [ + 157632 + ], + "children": [], + "area": 9238878.717161998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 157642, + "strid": "e665c4ed-b9a9-4d58-9529-77ac848ee53b", + "image_id": 206658, + "image_name": "6202.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2783.169, + 4152.197, + 474.759, + 402.0479999999998 + ], + "priority": 20, + "parents": [ + 157632 + ], + "children": [], + "area": 11556265.972293, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 31242, + "strid": "262767d0-785b-46e4-9fae-9f1fda8f6370", + "image_id": 201725, + "image_name": "117577.png", + "category_id": 9, + "category_name": "Root", + "bbox": [ + 3659.54, + 524.56, + 94.34000000000015, + 198.12 + ], + "priority": -1, + "parents": [], + "children": [ + 31211, + 31216, + 31217, + 31212, + 31210, + 31213, + 31214, + 31215, + 31218 + ], + "area": 1919648.3023999997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 31210, + "strid": "18a777f5-56bd-464f-b3fc-930cccce4277", + "image_id": 201725, + "image_name": "117577.png", + "category_id": 1, + "category_name": "Title", + "bbox": [ + 60.42, + 77.642, + 3671.301, + 385.973 + ], + "priority": 1, + "parents": [ + 31242 + ], + "children": [], + "area": 4691.12964, + "iscrowd": 0, + "segmentation": [], + "text": "A Low-Cost, Computer-Interfaced Drawing Pad\nfor fMRI. Studies of Dysgraphia and Dyslexia" + }, + { + "id": 31211, + "strid": "e0c12bea-2598-4947-85e0-39b19f3f6d8f", + "image_id": 201725, + "image_name": "117577.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 77.916, + 512.552, + 3524.07, + 237.83799999999997 + ], + "priority": 2, + "parents": [ + 31242 + ], + "children": [], + "area": 39936.001632, + "iscrowd": 0, + "segmentation": [], + "text": "Frederick Reitz'*, Todd Richards?, Kelvin Wu?, Peter Boord?, Mary Askren2, Fhomas Lewis?, and Virginia Berninger2. 1 [Instrument Development Lab, Center on Human\nDevelopment and Disability, University of Washington, Seattle, WA 98195, USA]. 2 [Integrated Brain Imaging Center, Dept. of Radiology, University of Washington, Seattle, WA\n98195, USA]. E-Mails’ wuanzinger@gmail.com (K.W.); tnlewis@uw.edu(T.L.); toddr@uw.edu (T.R.); pboord@uw.edu (P.B.)askren@uw.edu (M.A.); vwb@uw.edu (V.B.).\n*Author to whommcorrespondence should be addressed: E-Mail: freitz@uw.edu; Tel.: +1-206-543-9023; Fax: +1-206-616+8580." + }, + { + "id": 31212, + "strid": "5756c569-e1d4-42d0-9d12-7a38b7f91bfa", + "image_id": 201725, + "image_name": "117577.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 131.233, + 1051.515, + 620.8420000000001, + 105.00900000000001 + ], + "priority": 3, + "parents": [ + 31242 + ], + "children": [ + 31219 + ], + "area": 137993.467995, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 31219, + "strid": "5f0b55b5-fff9-4a49-8770-815d399b3441", + "image_id": 201725, + "image_name": "117577.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 136.139, + 1233.595, + 1068.283, + 1129.8819999999998 + ], + "priority": 4, + "parents": [ + 31212 + ], + "children": [], + "area": 167940.389705, + "iscrowd": 0, + "segmentation": [], + "text": "We have developed a pen and writing tablet for use\nby subjects during fMRI scanning. The pen consists\nof two optical fibers routed to the tip of a hollowed-\nout ball-point pen. The tablet is simply a non-\nmetallic frame holding a paper print of continuously\nvarying color gradients. The optical fibers are routed\nout of the MRI bore to a light-tight box in an\nadjacent control room. Within the box, light from a\nhigh intensity LED is coupled into one of the fibers,\nwhile the other fiber abuts a color sensor. Light\nfrom the LED exits the pen tip, illuminating a small\nspot.on the tablet, and the resulting reflected light\nis routed to the color sensor. Given a lookup table of\nposition for each color on the tablet, the\ncoordinates of the pen on the tablet may be\ndigitized in real-time. While simple and inexpensive,\nthe system achieves sufficient resolution to grade\nwriting tasks testing dysgraphic and dyslexic\nphenomena." + }, + { + "id": 31213, + "strid": "7096c3cd-d9d4-4d94-ae87-6f7739c57022", + "image_id": 201725, + "image_name": "117577.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 131.086, + 2483.54, + 816.781, + 109.52700000000004 + ], + "priority": 5, + "parents": [ + 31242 + ], + "children": [ + 31223 + ], + "area": 325557.32444000005, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 31223, + "strid": "0a5f9036-099f-4216-8773-1a79c9f7370a", + "image_id": 201725, + "image_name": "117577.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 134.865, + 2670.255, + 1051.316, + 587.203 + ], + "priority": 6, + "parents": [ + 31213 + ], + "children": [], + "area": 360123.940575, + "iscrowd": 0, + "segmentation": [], + "text": "We seek to understand the neural substrates of\ndysgraphia (a handwriting disorder [1]) and\ndyslexia. Zakzanis et al. [2] and Tam et al. [3] have\npreviously developed fMRI-compatible writing\ndevices, though for many studies of\ndyslexia/dysgraphia, fine resolution is less centrally\nimportant than the ability to qualitatively grade\nresponses and correlate them with brain activation,\nand a very simple, inexpensive system such as the\none described herein suffices." + }, + { + "id": 31214, + "strid": "1d576a9d-0d08-4f3f-9fec-2454097b9d9c", + "image_id": 201725, + "image_name": "117577.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 132.854, + 3368.687, + 593.979, + 109.84700000000021 + ], + "priority": 7, + "parents": [ + 31242 + ], + "children": [ + 31235, + 31225, + 31224, + 31234, + 31220, + 31231, + 31222, + 31233 + ], + "area": 447543.54269800003, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 31224, + "strid": "6286f593-7a14-4c4d-bcda-396c5ff5cc50", + "image_id": 201725, + "image_name": "117577.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 139.566, + 3551.376, + 1054.96, + 470.76800000000003 + ], + "priority": 8, + "parents": [ + 31214 + ], + "children": [], + "area": 495651.34281600005, + "iscrowd": 0, + "segmentation": [], + "text": "Light is launched into, and collected from, a pair of\n2mm, multimode, plastic optical fibers. The fibers\nare epoxied in place within the emptied plastic shell\nof a disposable ball-point pen, in turn epoxied\nperpendicularly into the drilled-out center of an\nacrylic plate. The “pen” prior to securing with glue\nand enclosure in heat-shrink tubing is shown in\nFigure 1." + }, + { + "id": 31233, + "strid": "c5512bdf-f775-441f-a98b-847204c150cf", + "image_id": 201725, + "image_name": "117577.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 100.85, + 4069.925, + 709.207, + 332.1099999999997 + ], + "priority": 9, + "parents": [ + 31214 + ], + "children": [ + 31238 + ], + "area": 410451.93624999997, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 31238, + "strid": "a0547df8-05e6-42de-a820-714ce206672b", + "image_id": 201725, + "image_name": "117577.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 129.485, + 4428.643, + 606.441, + 213.22000000000025 + ], + "priority": 10, + "parents": [ + 31233 + ], + "children": [], + "area": 573442.8388550001, + "iscrowd": 0, + "segmentation": [], + "text": "Fig 1. Pen with\n2 optical fibers" + }, + { + "id": 31234, + "strid": "5bea3cad-b438-4abe-8db7-0551c38f0cfa", + "image_id": 201725, + "image_name": "117577.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 858.92, + 4065.969, + 349.1340000000001, + 337.10099999999966 + ], + "priority": 11, + "parents": [ + 31214 + ], + "children": [ + 31239 + ], + "area": 3492342.09348, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 31239, + "strid": "7fc7f2a6-13b2-4b9f-bfaa-ec704192cbee", + "image_id": 201725, + "image_name": "117577.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 846.791, + 4425.401, + 465.312, + 213.04799999999977 + ], + "priority": 12, + "parents": [ + 31234 + ], + "children": [], + "area": 3747389.738191, + "iscrowd": 0, + "segmentation": [], + "text": "Fig 2. Color\nmap print" + }, + { + "id": 31225, + "strid": "42705234-a154-42b5-b338-3aa738ad51f8", + "image_id": 201725, + "image_name": "117577.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 135.691, + 4696.286, + 1030.985, + 735.0900000000001 + ], + "priority": 13, + "parents": [ + 31214 + ], + "children": [], + "area": 637243.743626, + "iscrowd": 0, + "segmentation": [], + "text": "The color sensor is a TAOS TCS230 color light-to-\nfrequency converter. Light from a Luxeon Rebel\n“Neutral White” Star LED is contact-coupled to the\nmap-illumination fiber, while the scattered-light-\ncollecting fiber is abutted to the light-sensitive\nregion of the TAOS sensor. Resulting pulse trains\nfrom the sensor are collected by a counter ona\nNational Instruments NI PCI-6025E board and read\ninto custom LabVIEW software.\n\nThe surface “written” upon is a continuously\nvarying color map (Figure 2) printed on\nconventional printer paper." + }, + { + "id": 31220, + "strid": "46aec8f9-650d-4d19-a4cb-1a2e9773ac42", + "image_id": 201725, + "image_name": "117577.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1365.64, + 982.398, + 1051.8499999999997, + 168.71500000000003 + ], + "priority": 14, + "parents": [ + 31214 + ], + "children": [], + "area": 1341602.00472, + "iscrowd": 0, + "segmentation": [], + "text": "The subject was shown stimuli via projection onto a\nmirror above the head coil. The pad is raised ona\n30 degree wedge of foam for comfort (Figure 3)." + }, + { + "id": 31235, + "strid": "ab343f09-a8cb-4426-a85d-a531a36fe58c", + "image_id": 201725, + "image_name": "117577.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1357.939, + 1191.959, + 1109.1120000000003, + 649.077 + ], + "priority": 15, + "parents": [ + 31214 + ], + "children": [ + 31236 + ], + "area": 1618607.6125010003, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 31236, + "strid": "ae03d8d3-f776-4d23-a4f9-3fe572b8c1ee", + "image_id": 201725, + "image_name": "117577.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1384.823, + 1863.863, + 757.2079999999999, + 97.31099999999992 + ], + "priority": 16, + "parents": [ + 31235 + ], + "children": [], + "area": 2581120.351249, + "iscrowd": 0, + "segmentation": [], + "text": "Fig 3. Tablet in use" + }, + { + "id": 31222, + "strid": "d3db19fc-69af-4216-a62a-cfc6bc9ffe91", + "image_id": 201725, + "image_name": "117577.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1379.936, + 2008.208, + 1041.626, + 350.6489999999999 + ], + "priority": 17, + "parents": [ + 31214 + ], + "children": [], + "area": 2771198.514688, + "iscrowd": 0, + "segmentation": [], + "text": "Calibration software turns calibration readings and\na desired number of pixels per axis into a lookup\ntable of X-Y positions for each RGB value, which is\nsaved to a file. Given such a table, the software can\naccept and display incoming data as a character\nbeing drawn on the screen in real time (Figure 4)." + }, + { + "id": 31231, + "strid": "69c12a10-4088-41c5-9847-18def3a40139", + "image_id": 201725, + "image_name": "117577.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 1352.938, + 2394.966, + 1107.114, + 775.069 + ], + "priority": 18, + "parents": [ + 31214 + ], + "children": [ + 31237 + ], + "area": 3240240.510108, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 31237, + "strid": "79222965-703f-49b4-a38a-cf5ae79687b2", + "image_id": 201725, + "image_name": "117577.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1363.186, + 3193.976, + 963.175, + 216.23700000000008 + ], + "priority": 19, + "parents": [ + 31231 + ], + "children": [], + "area": 4353983.367536, + "iscrowd": 0, + "segmentation": [], + "text": "Fig 4. Real-time\nhandwriting digitization" + }, + { + "id": 31215, + "strid": "c0f6e912-fa89-404e-8c13-362330b2cd60", + "image_id": 201725, + "image_name": "117577.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1391.15, + 3512.999, + 504.0, + 107.39699999999993 + ], + "priority": 20, + "parents": [ + 31242 + ], + "children": [ + 31221, + 31226, + 31232, + 31230 + ], + "area": 4887108.55885, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 31226, + "strid": "db53a337-35e4-4cf2-9bcf-da82bdac77b3", + "image_id": 201725, + "image_name": "117577.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1377.886, + 3693.845, + 1075.301, + 1156.7980000000002 + ], + "priority": 21, + "parents": [ + 31215 + ], + "children": [], + "area": 5089697.31167, + "iscrowd": 0, + "segmentation": [], + "text": "Calculated pixel positions showed a sub-pixel\nvariation (standard deviation of ~2.7 mm) uniformly\nover the center-most 50% of each range field,\nincreasing to ~5.4 mm over the outer-most\nquadrants of each axis. Time lag between pen\nmotion and display of the stroke on the screen is\n~130 ms at present.\n\nTo assess whether the writing task using the pen\ninduces head motion, the FSL software tool MCFLIRT\n[4] was used to assess head motion. as a mean\nabsolute displacement and as.a relative\ndisplacement using the fMRI head signal during 13\nminutes each of reading and writing tasks using our\npen inside the scanner. Our preliminary data shows\nlittle difference between the motion during the\nreading task compared with the writing task,\nsuggesting that use of the device does not\nnecessarily increase head motion\n\nmaterially (Table 1)." + }, + { + "id": 31230, + "strid": "ff207d0b-ae92-4d80-b4c1-2cf090b1e0b5", + "image_id": 201725, + "image_name": "117577.png", + "category_id": 7, + "category_name": "Table", + "bbox": [ + 1361.953, + 4921.959, + 1105.0989999999997, + 389.08899999999994 + ], + "priority": 22, + "parents": [ + 31215 + ], + "children": [ + 31240 + ], + "area": 6703476.825927, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 31240, + "strid": "f8717167-aca2-4dfe-8294-d948964ed7c5", + "image_id": 201725, + "image_name": "117577.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 1352.171, + 5341.08, + 1152.1759999999997, + 96.59299999999985 + ], + "priority": 23, + "parents": [ + 31230 + ], + "children": [], + "area": 7222053.48468, + "iscrowd": 0, + "segmentation": [], + "text": "Table 1. Head remaining still" + }, + { + "id": 31221, + "strid": "3767d7db-5ad5-42ef-87d3-f5cb795fa8a8", + "image_id": 201725, + "image_name": "117577.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2628.221, + 977.836, + 1061.8520000000003, + 650.279 + ], + "priority": 24, + "parents": [ + 31215 + ], + "children": [], + "area": 2569969.109756, + "iscrowd": 0, + "segmentation": [], + "text": "The functional connectivity maps were created from\nfMRI scans of 11 year old subjects with either\ndysgraphia or dyslexia (Figure 5) while performing\nthe writing task using the pen described herein. This\nconnectivity analysis was based on a seed region in\nBroca’s area on the left side of the brain. The\nclusters of activity are mainly in Broca’s area, motor\narea, angular gyrus and frontal areas. Our\npreliminary result shows more connections from\nBroca’s area in the dyslexic subject than in the\ndysgraphic subject." + }, + { + "id": 31232, + "strid": "d468d814-6422-4018-8c6d-8814762abbd0", + "image_id": 201725, + "image_name": "117577.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 2577.766, + 1668.403, + 1126.739, + 1068.9730000000002 + ], + "priority": 25, + "parents": [ + 31215 + ], + "children": [ + 31241 + ], + "area": 4300752.527698, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 31241, + "strid": "4eb1bc33-1c52-4757-b9cb-61641308c2d7", + "image_id": 201725, + "image_name": "117577.png", + "category_id": 6, + "category_name": "Caption", + "bbox": [ + 2568.619, + 2760.544, + 1164.6370000000002, + 93.60300000000007 + ], + "priority": 26, + "parents": [ + 31232 + ], + "children": [], + "area": 7090785.768736, + "iscrowd": 0, + "segmentation": [], + "text": "Fig. 5 Dysgraphia vs. dyslexia" + }, + { + "id": 31218, + "strid": "a6e738a5-8f16-4118-aa38-b3f79c6425ff", + "image_id": 201725, + "image_name": "117577.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2627.127, + 2956.256, + 816.0210000000002, + 110.70299999999997 + ], + "priority": 27, + "parents": [ + 31242 + ], + "children": [ + 31227 + ], + "area": 7766459.9565119995, + "iscrowd": 0, + "segmentation": [], + "text": "CONCLUSIONS" + }, + { + "id": 31227, + "strid": "1bb3e74d-8d4e-4cef-85a3-74f041604486", + "image_id": 201725, + "image_name": "117577.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2610.878, + 3146.12, + 1037.4969999999998, + 649.3969999999999 + ], + "priority": 28, + "parents": [ + 31218 + ], + "children": [], + "area": 8214135.493360001, + "iscrowd": 0, + "segmentation": [], + "text": "In sum, we find the device as implemented usable\nfor fMRI studies of dyslexia and dysgraphia.\nConstruction was straightforward and inexpensive\n(~$100 of parts beyond the cost of the LabVIEW\ndevelopment environment and data acquisition\ncard). Use of the device was comfortable, did not\ninduce prohibitive motion artifact during fMRI, and\nachieved high enough spatial (several mm) and\ntemporal (~30 points per second with ~130 ms lag)\nresolution to legibly discern dyslexic/dysgraphic\nphenomena." + }, + { + "id": 31217, + "strid": "cff8223a-54b3-45b1-983b-19d307e7aa90", + "image_id": 201725, + "image_name": "117577.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2625.763, + 3907.39, + 1021.5160000000001, + 85.91499999999996 + ], + "priority": 29, + "parents": [ + 31242 + ], + "children": [ + 31228 + ], + "area": 10259880.088569999, + "iscrowd": 0, + "segmentation": [], + "text": "KNOWLEDGEMENTS" + }, + { + "id": 31228, + "strid": "2cb6b0b7-bd8e-4b37-a646-c47c82daddf8", + "image_id": 201725, + "image_name": "117577.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 2623.35, + 4081.026, + 1042.7599999999998, + 226.5600000000004 + ], + "priority": 30, + "parents": [ + 31217 + ], + "children": [], + "area": 10705959.5571, + "iscrowd": 0, + "segmentation": [], + "text": "This project received engineering support from the\nUW CHDD IDL funded by NIH Grant HD002274, and\n\nfinancial support from the NIH/NICHD Grant\n1P50HDO71764." + }, + { + "id": 31216, + "strid": "fb20aeaa-ae0c-43b2-a9ef-f340ee6c41ca", + "image_id": 201725, + "image_name": "117577.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 2619.938, + 4412.364, + 767.781, + 110.89999999999964 + ], + "priority": 31, + "parents": [ + 31242 + ], + "children": [ + 31229 + ], + "area": 11560120.113432, + "iscrowd": 0, + "segmentation": [], + "text": "" + }, + { + "id": 31229, + "strid": "0253d3d9-c728-430a-b76a-3938123be28b", + "image_id": 201725, + "image_name": "117577.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 2593.848, + 4621.22, + 1063.277, + 816.1490000000003 + ], + "priority": 32, + "parents": [ + 31216 + ], + "children": [], + "area": 11986742.254560001, + 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expression." + }, + { + "id": 199397, + "strid": "68de7219-1ab3-413d-bde2-c2ccb2cbfef3", + "image_id": 208306, + "image_name": "9897.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 103.587, + 3377.126, + 3122.797, + 660.2089999999998 + ], + "priority": 16, + "parents": [ + 199386 + ], + "children": [], + "area": 349826.350962, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 199387, + "strid": "c8487315-5386-4d12-8f99-9ce2eb0dfaf8", + "image_id": 208306, + "image_name": "9897.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 83.992, + 4130.767, + 343.796, + 48.90800000000036 + ], + "priority": 17, + "parents": [ + 199398 + ], + "children": [ + 199396 + ], + "area": 346951.381864, + "iscrowd": 0, + "segmentation": [], + "text": "Conclusions" + }, + { + "id": 199396, + "strid": "85dff292-fed2-4202-92a8-51b35bac2b74", + "image_id": 208306, + "image_name": "9897.png", + "category_id": 4, + "category_name": "List", + "bbox": [ + 238.38, + 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0, + "segmentation": [], + "text": "Axonal and dendritic density field estimation from incomplete single-slice\nneuronal reconstructions" + }, + { + "id": 79668, + "strid": "a6091eef-d894-4809-b754-e5bf2efb0ac8", + "image_id": 203611, + "image_name": "120556.png", + "category_id": 0, + "category_name": "Author Info", + "bbox": [ + 15.766, + 489.723, + 3269.1, + 202.49600000000004 + ], + "priority": 2, + "parents": [ + 79694 + ], + "children": [], + "area": 7720.972818, + "iscrowd": 0, + "segmentation": [], + "text": "Jaap van Pelt\", Arjen van Ooyen’, Harry B.M. Uylings2\n1 Computational Neuroscience Group, Department of Integrative Neurophysiology, CNCR, VU University Amsterdam. 2 Dept.\nAnatomy & Neuroscience, VU University Medical Center, Amsterdam, The Netherlands" + }, + { + "id": 79669, + "strid": "e3e887af-6a5d-4da0-bbaf-5a209c3cb772", + "image_id": 203611, + "image_name": "120556.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 389.931, + 746.082, + 325.075, + 47.464000000000055 + ], + "priority": 3, + "parents": [ + 79694 + ], + "children": [ + 79681, + 79693 + ], + "area": 290920.500342, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction" + }, + { + "id": 79693, + "strid": "e13bec15-48c8-4f38-9a9d-d6a54a27268d", + "image_id": 203611, + "image_name": "120556.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 32.171, + 811.517, + 1044.344, + 595.414 + ], + "priority": 4, + "parents": [ + 79669 + ], + "children": [], + "area": 26107.313407, + "iscrowd": 0, + "segmentation": [], + "text": "Introduction: Synaptic connections between neurons\ncan form when their axons and dendrites come in close\nproximity of each other. Synaptic connectivity can be\nestimated from the spatial overlap of population mean\naxonal and dendritic density fields (Van Pelt et al., 2010;\nVan Pelt and Van Ooyen, 2013). Calculating population\nmean density fields requires a sufficient number of\nexperimentally reconstructed neurons. Much\nmorphological data, made available via open-access\ndatabases, however, is derived from single slice\nneuronal reconstructions, which are generally\nincomplete because of cut branches." + }, + { + "id": 79681, + "strid": "a3f506ff-5ad4-44aa-b14f-3a278ad2389b", + "image_id": 203611, + "image_name": "120556.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 31.97, + 1411.835, + 1044.71, + 694.5169999999998 + ], + "priority": 5, + "parents": [ + 79669 + ], + "children": [], + "area": 45136.36495, + "iscrowd": 0, + "segmentation": [], + "text": "Research Question: Can we recover the lost mass by\nmeasuring the mass inside the slice and extrapolation to\nthe space outside the slice?\n\nApproach: Assume axial symmetry in the spatial\ndistribution of neuronal mass to extrapolate inside mass\ndensities to the outside space. This ‘completion method'\nhas been validated using a set of NETMORPH\ngenerated neurons which were artificially sliced and\nsubsequently recovered by the completion method. The\ncompletion method has been applied to three\nexperimental data sets of reconstructed rat cortical L2/3\npyramidal neurons, with the “Svoboda” and “Markram”\ndata set obtained from the NeuroMorpho.Org database\n(Ascoli, 2006) and our own Parnavelas/Uylings data set." + }, + { + "id": 79671, + "strid": "ca073ddf-5464-4ef1-b6d2-cd86ba35b7f7", + "image_id": 203611, + "image_name": "120556.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 90.743, + 2169.439, + 948.182, + 59.24299999999994 + ], + "priority": 6, + "parents": [ + 79694 + ], + "children": [ + 79687 + ], + "area": 196861.40317699997, + "iscrowd": 0, + "segmentation": [], + "text": "Cut and orphan branches by slicing" + }, + { + "id": 79687, + "strid": "72cb8449-bcdc-415a-a869-8169ec5a225e", + "image_id": 203611, + "image_name": "120556.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 32.284, + 2242.644, + 1050.155, + 350.34400000000005 + ], + "priority": 7, + "parents": [ + 79671 + ], + "children": [], + "area": 72401.518896, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 79672, + "strid": "349f3b87-910e-4001-968f-b80bc56289c1", + "image_id": 203611, + "image_name": "120556.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 168.62, + 2643.647, + 782.668, + 49.05400000000009 + ], + "priority": 8, + "parents": [ + 79694 + ], + "children": [ + 79688 + ], + "area": 445771.75714, + "iscrowd": 0, + "segmentation": [], + "text": "Axial-radial mass distribution" + }, + { + "id": 79688, + "strid": "f91a5765-ada3-4cbc-99e2-e91e5b1e5730", + "image_id": 203611, + "image_name": "120556.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 118.657, + 2709.824, + 875.421, + 886.982 + ], + "priority": 9, + "parents": [ + 79672 + ], + "children": [], + "area": 321539.586368, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 79673, + "strid": "f956984f-8c5a-4b00-910b-8b36368e5574", + "image_id": 203611, + "image_name": "120556.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 260.546, + 3610.091, + 594.644, + 59.92500000000018 + ], + "priority": 10, + "parents": [ + 79694 + ], + "children": [ + 79689 + ], + "area": 940594.769686, + "iscrowd": 0, + "segmentation": [], + "text": "Mass integration rings" + }, + { + "id": 79689, + "strid": "6df12936-27df-4e9c-a7a1-a00893b99586", + "image_id": 203611, + "image_name": "120556.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 115.302, + 3672.493, + 901.993, + 401.8359999999998 + ], + "priority": 11, + "parents": [ + 79673 + ], + "children": [], + "area": 423445.787886, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 79674, + "strid": "2bbfdc1e-b21f-46b5-aaaf-c92758981165", + "image_id": 203611, + "image_name": "120556.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 48.727, + 4114.29, + 1019.343, + 58.65099999999984 + ], + "priority": 12, + "parents": [ + 79694 + ], + "children": [ + 79690 + ], + "area": 200477.00882999998, + "iscrowd": 0, + "segmentation": [], + "text": "Mass loss in sliced Netmorph neurons" + }, + { + "id": 79690, + "strid": "5e79ce97-2d83-414a-901b-4d5afe6d86af", + "image_id": 203611, + "image_name": "120556.png", + "category_id": 2, + "category_name": "Figure", + "bbox": [ + 34.607, + 4175.526, + 1041.257, + 357.9359999999997 + ], + "priority": 13, + "parents": [ + 79674 + ], + "children": [], + "area": 144502.42828199998, + "iscrowd": 0, + "segmentation": [] + }, + { + "id": 79670, + "strid": "f5832b4f-f5ef-4a4c-8c75-5d2dea23281a", + "image_id": 203611, + "image_name": "120556.png", + "category_id": 5, + "category_name": "Section", + "bbox": [ + 1155.892, + 732.972, + 977.673, + 59.370000000000005 + ], + "priority": 14, + "parents": [ + 79694 + ], + "children": [ + 79682 + ], + "area": 847236.471024, + "iscrowd": 0, + "segmentation": [], + "text": "Mass completion per integration ring" + }, + { + "id": 79682, + "strid": "9ad1e5cf-0a9f-4880-b6fd-7e2adb51813f", + "image_id": 203611, + "image_name": "120556.png", + "category_id": 3, + "category_name": "Text", + "bbox": [ + 1120.437, + 840.485, + 1046.4740000000002, + 1751.8739999999998 + ], + "priority": 15, + "parents": [ + 79670 + ], + "children": [], + "area": 941710.4919449999, + "iscrowd": 0, + "segmentation": [], + "text": "A. Ring fully within slice: H>r and T—H>r\nRing volume fraction: F'(r) = 2aror/2zror =1\n\nB. Ring extends the slice on one of its sides:\nH>r and T—H