{
  "title": "Open Syndrome Smallpox",
  "language": "English",
  "version": "1.0.0",
  "location": "Costa Rica",
  "scope": "broad",
  "category": "suspected",
  "organization": "Caja Costarricense de Seguro Social",
  "authors": [
    "Dirección de Desarrollo de Servicios de Salud"
  ],
  "open_syndrome_version": "1.0.0",
  "published_in": "https://opensyndrome.org",
  "published_at": "2025-02-08T17:44:54Z",
  "published_by": [
    "Open Syndrome Initiative"
  ],
  "inclusion_criteria": [
    {
      "type": "criterion",
      "logical_operator": "AND",
      "values": [
        {
          "type": "symptom",
          "name": "Acute unexplained rash",
          "attribute": "onset_date",
          "operator": "<",
          "value": "2022-03-15"
        },
        {
          "type": "criterion",
          "name": "One or more of the following symptoms",
          "logical_operator": "AT_LEAST",
          "logical_operator_arguments": [
            1
          ],
          "values": [
            {
              "type": "symptom",
              "name": "Headache"
            },
            {
              "type": "symptom",
              "name": "Sudden onset fever",
              "description": "Sudden onset fever (>38.5°C)"
            },
            {
              "type": "symptom",
              "name": "Muscle pain"
            },
            {
              "type": "symptom",
              "name": "Back pain"
            },
            {
              "type": "symptom",
              "name": "Fatigue"
            },
            {
              "type": "symptom",
              "name": "Lymphadenopathy"
            }
          ]
        }
      ]
    }
  ],
  "exclusion_criteria": [
    {
      "name": "Cause of ruling out acute exanthema",
      "type": "criterion",
      "logical_operator": "OR",
      "values": [
        {
          "type": "diagnosis",
          "name": "Chickenpox"
        },
        {
          "type": "diagnosis",
          "name": "Shingles"
        },
        {
          "type": "diagnosis",
          "name": "Measles"
        },
        {
          "type": "diagnosis",
          "name": "Rubella"
        },
        {
          "type": "diagnosis",
          "name": "Zika virus"
        },
        {
          "type": "diagnosis",
          "name": "Dengue fever"
        },
        {
          "type": "diagnosis",
          "name": "Chikungunya virus"
        },
        {
          "type": "diagnosis",
          "name": "Common cold herpes"
        },
        {
          "type": "diagnosis",
          "name": "Bacterial skin infections"
        },
        {
          "type": "diagnosis",
          "name": "Disseminated gonococcal infection"
        },
        {
          "type": "diagnosis",
          "name": "Primary or secondary syphilis"
        },
        {
          "type": "diagnosis",
          "name": "Chancroid"
        },
        {
          "type": "diagnosis",
          "name": "Lymphogranuloma venereum"
        },
        {
          "type": "diagnosis",
          "name": "Granuloma inguinale"
        },
        {
          "type": "diagnosis",
          "name": "molluscum contagiosum"
        },
        {
          "type": "diagnosis",
          "name": "allergic reaction (for example, to plants)"
        },
        {
          "type": "diagnosis",
          "name": "vesicular or papular rash"
        }
      ]
    }
  ],
  "references": [
    {
      "citation": "",
      "url": "https://www.cendeisss.sa.cr/wp/wp-content/uploads/2024/04/Protocolo-Viruela-Simica.CCSS_.pdf"
    }
  ],
  "status": "draft",
  "human_readable_definition": "Persona de cualquier edad que se presenta con un exantema agudo inexplicable y que\npresentó uno o más de los siguientes signos o síntomas, con fecha de inicio posterior al 15\nde marzo de 2022:\n- Cefalea\n- Inicio súbito fiebre (>38,5°C)\n- Mialgia\n- Dolor de espalda\n- Astenia\n- Linfadenopatía\nY\npara los cuales se ha descartado, las siguientes y otras causas de exantema agudo que se\nmencionan a continuación: varicela, herpes zóster, sarampión, rubéola, zika, dengue,\nchikungunya, herpes simple, infecciones bacterianas de la piel, infección gonocócica\ndiseminada, sífilis primaria o secundaria, chancroide, linfogranuloma venéreo, granuloma\ninguinal, molusco contagioso, reacción alérgica (por ejemplo, a las plantas); y cualquier otra\ncausa común, localmente relevante de erupción vesicular o papular.\nNo es necesario tener resultados negativos de todas las enfermedades exantemáticas para\ndeterminar un caso como sospechoso.",
  "target_public_health_threats": [
    "Smallpox"
  ],
  "keywords": [
    "Smallpox",
    "North America"
  ],
  "definition_type": "case_definition"
}