Update README.md

Updating as a part of hugging science initiative - belive there is value in OpenTargets dataset being utilized fully

README.md

@@ -1,10 +1,96 @@
 ---
 license: apache-2.0
+language:
+- en
+tags:
+- huggingscience
+- science
+pretty_name: clinical_trial_stopped_evidence
+size_categories:
+- 1M<n<10M
 ---
 
-## Clinical evidence
+## OpenTargets Clinical Evidence Dataset
 
-Dataset of clinical studies annotated with their predicted stop reason and genetic evidence when available.
-Referenced in https://doi.org/10.1101/2023.02.07.23285407
+This OpenTargets clinical evidence dataset represents a comprehensive collection of clinical trial data linking genetic targets to diseases, containing 32 structured columns that capture the complete lifecycle of clinical studies. 
+The dataset is annotated with clinical trials' predicted stop reason and genetic evidence when available and was referenced in the _[Why Clinical Trials Stop: The Role of Genetics](https://doi.org/10.1101/2023.02.07.23285407)_. 
+The study analyzed 28,842 stopped clinical trials and demonstrated that genetic evidence significantly influences trial efficacy,
 
-Generated with the 22.04 Open Targets Data with [this script](https://github.com/opentargets/stopReasons/blob/main/analysis/python/enrichments.py).
+## Tutorial
+
+To access the dataset, you can use HF datasets:
+```
+from datasets import load_dataset
+
+ds = load_dataset("opentargets/clinical_evidence")
+
+# see first record
+next(ds.iter(1))
+```
+
+## Features
+
+The dataset contains a lot of genetic and clinical features which can be used for ML modelling.
+
+The features are summarized in the table below:
+
+| Column Name | Data Type | Description | Example Values |
+|-------------|-----------|-------------|----------------|
+| **targetId** | string | Ensembl gene identifier representing the target gene | `ENSG00000004468`, `ENSG00000065518` |
+| **diseaseId** | string | Disease ontology identifier using EFO or MONDO terms | `EFO_0000203`, `MONDO_0005148` |
+| **nctid** | string | ClinicalTrials.gov identifier for the clinical trial | `NCT03236428`, `NCT01089192` |
+| **clinicalStatus** | string | Current status of the clinical trial | `Active, not recruiting`, `Completed`, `Withdrawn`, `Terminated`, `Suspended` |
+| **clinicalPhase** | int64 | Numeric representation of the clinical trial phase | `1`, `2`, `3`, `4` |
+| **studyStartDate** | string | Date when the clinical trial began (YYYY-MM-DD format) | `2017-11-24`, `2016-11-30` |
+| **stopStatus** | string | Reason for trial discontinuation (null if ongoing/completed normally) | `null`, `Withdrawn`, `Terminated`, `Suspended` |
+| **isStopped** | string | Boolean indicator if the trial was stopped | `stopped`, `null` |
+| **phase4** | string | Indicates if this is a Phase IV (post-marketing) trial | `Phase IV`, `null` |
+| **phase3** | string | Indicates if this is a Phase III trial | `Phase III+`, `null` |
+| **phase2** | string | Indicates if this is a Phase II trial | Various phase indicators, `null` |
+| **id** | int64 | Internal record identifier | Numeric identifiers |
+| **why_stopped** | string | Detailed reason why a trial was discontinued | Trial-specific discontinuation reasons |
+| **phase** | string | String representation of the trial phase | Phase descriptors |
+| **status** | string | Trial status information | Status descriptions |
+| **last_update_posted_date** | string | Most recent update to the trial record | Date strings |
+| **completion_date** | string | Date when the trial was completed (if applicable) | Date strings |
+| **prediction** | string | Computational prediction about the target-disease association | Prediction values |
+| **metaprediction** | string | Meta-analysis prediction combining multiple evidence sources | Meta-prediction values |
+| **max_l2g** | double | Maximum locus-to-gene (L2G) score indicating genetic evidence strength | Floating point scores |
+| **l2g_075** | string | L2G score threshold at 0.75 confidence level | Threshold indicators |
+| **l2g_05** | string | L2G score threshold at 0.5 confidence level | Threshold indicators |
+| **l2g_025** | string | L2G score threshold at 0.25 confidence level | Threshold indicators |
+| **l2g_01** | string | L2G score threshold at 0.1 confidence level | Threshold indicators |
+| **l2g_005** | string | L2G score threshold at 0.05 confidence level | Threshold indicators |
+| **taId** | string | Therapeutic area identifier | Therapeutic area codes |
+| **taLabel** | string | Full therapeutic area label | Therapeutic area names |
+| **taLabelSimple** | string | Simplified therapeutic area label | Simplified area names |
+| **gc** | double | Gene constraint score | Floating point constraint scores |
+| **lof_tolerance** | string | Loss-of-function tolerance classification | Tolerance classifications |
+| **rnaDistribution** | string | RNA expression distribution pattern | Distribution patterns |
+| **rnaSpecificity** | string | RNA expression specificity | Specificity measures |
+| **partnersBin** | string | Protein interaction partners classification | Partner classifications |
+| **datasourceId** | string | Identifier for the data source | Data source identifiers |
+| **datatypeId** | string | Type of evidence data | Evidence type identifiers |
+| **total** | int64 | Total count or score for the evidence | Numeric totals |
+
+
+
+
+## Citation
+```
+@article{razuvayevskaya2023clinical,
+  title={Why Clinical Trials Stop: The Role of Genetics},
+  author={Razuvayevskaya, Olesya and Lopez, Irene and Dunham, Ian and Ochoa, David},
+  journal={medRxiv},
+  pages={2023--02},
+  year={2023},
+  publisher={Cold Spring Harbor Laboratory},
+  doi={10.1101/2023.02.07.23285407}
+}
+```
+
+## OpenTargets
+Interested in other datasets or research related to drug or target discovery? Visit [OpenTargets Platform](https://www.opentargets.org/)
+
+## Reproduction
+Dataset was generated with the 22.04 Open Targets Data with [this script](https://github.com/opentargets/stopReasons/blob/main/analysis/python/enrichments.py).