index,Instruction,molecule,removed_group
179262,Remove a hydroxyl from the molecule COc1ccc2occ(/C(C)=N/O)c2c1.,COc1ccc2occ(/C(C)=N/O)c2c1,hydroxyl
144889,Please remove a benzene_ring from the molecule CCOC(=O)c1cccc(N[C@H]2CSCC(C)(C)C2)c1.,CCOC(=O)c1cccc(N[C@H]2CSCC(C)(C)C2)c1,benzene_ring
153213,Remove a amide from the molecule O=C(CN1CCCOC1=O)NCCc1nc(C(F)(F)F)cs1.,O=C(CN1CCCOC1=O)NCCc1nc(C(F)(F)F)cs1,amide
246361,Please remove a hydroxyl from the molecule Oc1ccc(O)c(C[NH2+]C2CCCCC2)c1.,Oc1ccc(O)c(C[NH2+]C2CCCCC2)c1,hydroxyl
197349,Please remove a benzene_ring from the molecule Cc1nn(Cc2ccccc2)c(C)c1C[NH+]1CCC[C@H](n2cccn2)C1.,Cc1nn(Cc2ccccc2)c(C)c1C[NH+]1CCC[C@H](n2cccn2)C1,benzene_ring
61981,Please remove a halo from the molecule N#C/C(=C\c1cccc(OC2CCCC2)c1)c1ccc(C(F)(F)F)cn1.,N#C/C(=C\c1cccc(OC2CCCC2)c1)c1ccc(C(F)(F)F)cn1,halo
62252,Remove a benzene_ring from the molecule Cc1ccc([C@@H](C)N(C)C(=O)c2nnn[n-]2)cc1.,Cc1ccc([C@@H](C)N(C)C(=O)c2nnn[n-]2)cc1,benzene_ring
136564,Please remove a amine from the molecule CC[C@@H](C(=O)OCC(=O)c1c(N)n(C)c(=O)n(C)c1=O)c1ccccc1.,CC[C@@H](C(=O)OCC(=O)c1c(N)n(C)c(=O)n(C)c1=O)c1ccccc1,amine
195910,Modify the molecule Cc1nc(C)n(-c2ccccc2NC(=O)N(C)C[C@H](C)c2ccccc2)n1 by removing a benzene_ring.,Cc1nc(C)n(-c2ccccc2NC(=O)N(C)C[C@H](C)c2ccccc2)n1,benzene_ring
113473,Modify the molecule CC(C)c1nc(-c2ccc(N3CCN(C(=O)Cc4noc5ccccc45)CC3)[nH+]c2)no1 by removing a amide.,CC(C)c1nc(-c2ccc(N3CCN(C(=O)Cc4noc5ccccc45)CC3)[nH+]c2)no1,amide
220138,Modify the molecule CCn1nc(C)cc1CNc1ccn(C)n1 by removing a amine.,CCn1nc(C)cc1CNc1ccn(C)n1,amine
232684,Modify the molecule CS(=O)(=O)c1ccc(C(=O)N2C[C@@H](C(=O)[O-])[C@H](c3ccncc3)C2)cc1 by removing a amide.,CS(=O)(=O)c1ccc(C(=O)N2C[C@@H](C(=O)[O-])[C@H](c3ccncc3)C2)cc1,amide
149280,Remove a amide from the molecule Cc1cc(C)c(C[S@](=O)CC(=O)N(C)c2ccccc2)c(C)c1.,Cc1cc(C)c(C[S@](=O)CC(=O)N(C)c2ccccc2)c(C)c1,amide
206890,Modify the molecule C[C@@H](SCc1ccccc1)C(=O)NC[C@@H](C)N1CC[NH+](C)CC1 by removing a benzene_ring.,C[C@@H](SCc1ccccc1)C(=O)NC[C@@H](C)N1CC[NH+](C)CC1,benzene_ring
147868,Remove a nitrile from the molecule N#C[C@H](c1ccccc1)N1CCN(Cc2csc(-c3ccoc3)n2)CC1.,N#C[C@H](c1ccccc1)N1CCN(Cc2csc(-c3ccoc3)n2)CC1,nitrile
41223,Please remove a nitro from the molecule COc1cc(/C(C#N)=C/c2cccc3c2OCCCO3)ccc1[N+](=O)[O-].,COc1cc(/C(C#N)=C/c2cccc3c2OCCCO3)ccc1[N+](=O)[O-],nitro
77273,Remove a amide from the molecule CN(C(=O)c1cc(=O)[nH]c2ccc(S(=O)(=O)[N-]c3ccc(F)cc3)cc12)[C@H]1CCS(=O)(=O)C1.,CN(C(=O)c1cc(=O)[nH]c2ccc(S(=O)(=O)[N-]c3ccc(F)cc3)cc12)[C@H]1CCS(=O)(=O)C1,amide
24420,Remove a hydroxyl from the molecule CC1(C)CC(NC(=O)N2CCN(C(=O)c3ccc(O)cc3)CC2)CC(C)(C)[NH2+]1.,CC1(C)CC(NC(=O)N2CCN(C(=O)c3ccc(O)cc3)CC2)CC(C)(C)[NH2+]1,hydroxyl
12689,Please remove a benzene_ring from the molecule Cc1cc(C)cc(C(=O)N2CC[C@H](C(=O)[O-])[C@@H]2C)c1.,Cc1cc(C)cc(C(=O)N2CC[C@H](C(=O)[O-])[C@@H]2C)c1,benzene_ring
247636,Remove a amide from the molecule CC(C)CC[S@@](=O)[C@@H](C)C(=O)Nc1cc(Cl)ccc1F.,CC(C)CC[S@@](=O)[C@@H](C)C(=O)Nc1cc(Cl)ccc1F,amide
19780,Remove a benzene_ring from the molecule Cc1ccc(S[C@H]2CSc3nc(C)cc(=O)n3[C@@H]2c2ccccc2)cc1.,Cc1ccc(S[C@H]2CSc3nc(C)cc(=O)n3[C@@H]2c2ccccc2)cc1,benzene_ring
84783,Remove a benzene_ring from the molecule O=[N+]([O-])c1ccc(OC/C=C2\Oc3c(cccc3[N+](=O)[O-])[C@H]2N2CCOCC2)cc1.,O=[N+]([O-])c1ccc(OC/C=C2\Oc3c(cccc3[N+](=O)[O-])[C@H]2N2CCOCC2)cc1,benzene_ring
132634,Modify the molecule CCNC(=O)Cn1cnc2cc(-c3ccc(OC)cc3)sc2c1=O by removing a amide.,CCNC(=O)Cn1cnc2cc(-c3ccc(OC)cc3)sc2c1=O,amide
111613,Please remove a amide from the molecule C[C@@H](Sc1nnc2ccc(C(F)(F)F)cn12)C(=O)N(C)C.,C[C@@H](Sc1nnc2ccc(C(F)(F)F)cn12)C(=O)N(C)C,amide
80126,Please remove a benzene_ring from the molecule Cc1ccccc1C(=O)NC(=S)Nc1sc2c(c1C#N)CCCC2.,Cc1ccccc1C(=O)NC(=S)Nc1sc2c(c1C#N)CCCC2,benzene_ring
143022,Please remove a amine from the molecule N#C[C@H]1CNCCN1C(=O)c1cccc(O)c1.,N#C[C@H]1CNCCN1C(=O)c1cccc(O)c1,amine
52384,Remove a benzene_ring from the molecule C=CCN(Cc1cccc(C#N)c1)Cc1c[nH]nc1-c1ccc2c(c1)OCCO2.,C=CCN(Cc1cccc(C#N)c1)Cc1c[nH]nc1-c1ccc2c(c1)OCCO2,benzene_ring
72886,Remove a benzene_ring from the molecule COC(CNc1ccc(Br)c([N+](=O)[O-])c1)OC.,COC(CNc1ccc(Br)c([N+](=O)[O-])c1)OC,benzene_ring
211197,Modify the molecule CCSc1cncc(NCc2scnc2C)n1 by removing a amine.,CCSc1cncc(NCc2scnc2C)n1,amine
63245,Modify the molecule Cc1ccc(C(C)(C)C)cc1[S@@](=O)Cc1cn2ccccc2n1 by removing a benzene_ring.,Cc1ccc(C(C)(C)C)cc1[S@@](=O)Cc1cn2ccccc2n1,benzene_ring
180555,Please remove a benzene_ring from the molecule Cc1c(C(=O)NC(c2ccccc2)c2ccccc2)nnn1-c1ccccc1.,Cc1c(C(=O)NC(c2ccccc2)c2ccccc2)nnn1-c1ccccc1,benzene_ring
131292,Modify the molecule Brc1cnc(N2CCCC2)cn1 by removing a halo.,Brc1cnc(N2CCCC2)cn1,halo
237254,Please remove a amide from the molecule O=C1CC[C@@]2(CCCN(C(=O)c3c[nH]c(=O)cn3)C2)CN1Cc1cccnc1.,O=C1CC[C@@]2(CCCN(C(=O)c3c[nH]c(=O)cn3)C2)CN1Cc1cccnc1,amide
20167,Remove a benzene_ring from the molecule NC(=O)[C@@H]1CCC[NH+]1[C@H](C(=O)[O-])c1c[nH]c2cc(NC(=O)c3ccccc3)ccc12.,NC(=O)[C@@H]1CCC[NH+]1[C@H](C(=O)[O-])c1c[nH]c2cc(NC(=O)c3ccccc3)ccc12,benzene_ring
204412,Remove a benzene_ring from the molecule Cc1ccc(C(=O)C(=O)N2CCOCC[C@H]2C)cc1.,Cc1ccc(C(=O)C(=O)N2CCOCC[C@H]2C)cc1,benzene_ring
227752,Please remove a benzene_ring from the molecule CCn1c(SCC(=O)NN)nnc1-c1ccc(C(C)(C)C)cc1.,CCn1c(SCC(=O)NN)nnc1-c1ccc(C(C)(C)C)cc1,benzene_ring
45404,Remove a benzene_ring from the molecule CC[C@H](C)c1ccc([C@@H](O)c2cscc2C)cc1.,CC[C@H](C)c1ccc([C@@H](O)c2cscc2C)cc1,benzene_ring
157681,Modify the molecule C[C@@H]1OCC[C@H]1C(=O)N[C@@H]1CC(=O)N(CC(F)(F)F)C1 by removing a amide.,C[C@@H]1OCC[C@H]1C(=O)N[C@@H]1CC(=O)N(CC(F)(F)F)C1,amide
127321,Remove a benzene_ring from the molecule CN(C(=O)COCCOc1ccccc1)c1cccc2ncccc12.,CN(C(=O)COCCOc1ccccc1)c1cccc2ncccc12,benzene_ring
158213,Modify the molecule CC(C)NC(=O)c1ccc(NCc2ccc(F)c(Br)c2)cc1 by removing a halo.,CC(C)NC(=O)c1ccc(NCc2ccc(F)c(Br)c2)cc1,halo
235427,Please remove a halo from the molecule O=C(C1=C([O-])C(=O)N(Cc2cccnc2)[C@H]1c1ccc(Cl)cc1)c1cccs1.,O=C(C1=C([O-])C(=O)N(Cc2cccnc2)[C@H]1c1ccc(Cl)cc1)c1cccs1,halo
100549,Please remove a amine from the molecule CCCCSc1nc2n(n1)[C@@H](c1sccc1C)C(C(C)=O)=C(C)N2.,CCCCSc1nc2n(n1)[C@@H](c1sccc1C)C(C(C)=O)=C(C)N2,amine
167518,Modify the molecule O=C([O-])CC1(NC(=O)CC2C[C@@H]3CC[C@H](C2)[NH2+]3)CCC1 by removing a amide.,O=C([O-])CC1(NC(=O)CC2C[C@@H]3CC[C@H](C2)[NH2+]3)CCC1,amide
197062,Remove a amide from the molecule O=C(CC[NH+]1CCC(C(F)(F)F)CC1)Nc1ccc(F)cc1.,O=C(CC[NH+]1CCC(C(F)(F)F)CC1)Nc1ccc(F)cc1,amide
170455,Modify the molecule C[C@@H](N[C@H](c1cccnc1)c1ccc(F)c(F)c1)c1cnn(C)c1 by removing a benzene_ring.,C[C@@H](N[C@H](c1cccnc1)c1ccc(F)c(F)c1)c1cnn(C)c1,benzene_ring
154548,Remove a amide from the molecule CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(CCO)S(C)(=O)=O)c(C3CC3)cc12.,CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(CCO)S(C)(=O)=O)c(C3CC3)cc12,amide
70993,Remove a hydroxyl from the molecule Cc1cc(C)cc(OC[C@H](O)C[NH+]2CCC[C@@H]2c2cc(C)no2)c1.,Cc1cc(C)cc(OC[C@H](O)C[NH+]2CCC[C@@H]2c2cc(C)no2)c1,hydroxyl
9072,Remove a amide from the molecule C[C@@H]1CN(C(=O)Cn2cc([N+](=O)[O-])cn2)CCO1.,C[C@@H]1CN(C(=O)Cn2cc([N+](=O)[O-])cn2)CCO1,amide
10234,Remove a benzene_ring from the molecule CCCOc1ccc([C@H]([NH3+])CC(=O)[O-])cc1.,CCCOc1ccc([C@H]([NH3+])CC(=O)[O-])cc1,benzene_ring
159737,Remove a benzene_ring from the molecule CC(C)NC(=O)CN(C)C(=O)CCc1nncn1-c1ccccc1.,CC(C)NC(=O)CN(C)C(=O)CCc1nncn1-c1ccccc1,benzene_ring
11121,Remove a amide from the molecule N#Cc1ccc(NC(=O)c2c3c(nc4ccccc24)CCC3)cc1Cl.,N#Cc1ccc(NC(=O)c2c3c(nc4ccccc24)CCC3)cc1Cl,amide
34805,Please remove a benzene_ring from the molecule O=C(NC[C@@H]1COC2(CCCC2)O1)Nc1c(F)cccc1Oc1ccccc1.,O=C(NC[C@@H]1COC2(CCCC2)O1)Nc1c(F)cccc1Oc1ccccc1,benzene_ring
213230,Please remove a amine from the molecule COc1cccc(N2C(=O)[C@@H]3C(C(=O)C(c4ccccc4)c4ccccc4)=NN[C@H]3C2=O)c1.,COc1cccc(N2C(=O)[C@@H]3C(C(=O)C(c4ccccc4)c4ccccc4)=NN[C@H]3C2=O)c1,amine
134808,Please remove a halo from the molecule C[C@@H](CO)NC(=O)NC[C@H](C)Oc1ccc(F)cc1.,C[C@@H](CO)NC(=O)NC[C@H](C)Oc1ccc(F)cc1,halo
220103,Remove a amide from the molecule C=CCNC(=O)CN1CCOC[C@H]1C#N.,C=CCNC(=O)CN1CCOC[C@H]1C#N,amide
156620,Please remove a benzene_ring from the molecule CC/[NH+]=C(/N[C@H]1C[C@@H]1c1cccc(Cl)c1)N[C@@H]1CCC(=O)NC1.,CC/[NH+]=C(/N[C@H]1C[C@@H]1c1cccc(Cl)c1)N[C@@H]1CCC(=O)NC1,benzene_ring
150300,Please remove a amide from the molecule CSCC(=O)NNC(=O)N[C@@H](C)Cc1c(C)noc1C.,CSCC(=O)NNC(=O)N[C@@H](C)Cc1c(C)noc1C,amide
232673,Please remove a amine from the molecule CN(C(=O)[O-])c1ccc2c(c1)CCN2.,CN(C(=O)[O-])c1ccc2c(c1)CCN2,amine
34252,Remove a amide from the molecule CC(C)NC(=O)c1cccc2c1NC(=O)C2.,CC(C)NC(=O)c1cccc2c1NC(=O)C2,amide
58359,Please remove a benzene_ring from the molecule COc1ccc(Br)c(COc2ccc(CC[NH3+])nc2)c1.,COc1ccc(Br)c(COc2ccc(CC[NH3+])nc2)c1,benzene_ring
79958,Modify the molecule COc1ccccc1C[C@@H](C)N(C)C(=O)N[C@@H]1CCC[C@H](SC)C1 by removing a benzene_ring.,COc1ccccc1C[C@@H](C)N(C)C(=O)N[C@@H]1CCC[C@H](SC)C1,benzene_ring
232789,Modify the molecule CCc1ccc(C(=O)O[C@@H](C)[C@@H]2CCCO2)cc1 by removing a benzene_ring.,CCc1ccc(C(=O)O[C@@H](C)[C@@H]2CCCO2)cc1,benzene_ring
103779,Modify the molecule C[C@@H](CCCCl)[NH2+]CCC(C)(C)C by removing a halo.,C[C@@H](CCCCl)[NH2+]CCC(C)(C)C,halo
227144,Remove a benzene_ring from the molecule COc1cc(OC)cc(C(=O)Nn2cc(C(=O)NCc3ccccn3)c3ccccc3c2=O)c1.,COc1cc(OC)cc(C(=O)Nn2cc(C(=O)NCc3ccccn3)c3ccccc3c2=O)c1,benzene_ring
111420,Modify the molecule COc1ccc(NC(=O)[C@@H]2CCC[NH+]2Cc2cc(-c3ccccc3)[nH]n2)cc1 by removing a benzene_ring.,COc1ccc(NC(=O)[C@@H]2CCC[NH+]2Cc2cc(-c3ccccc3)[nH]n2)cc1,benzene_ring
17480,Remove a amide from the molecule COc1ccc(C(=O)NC[C@@H]2CCCC[C@@H]2C[NH3+])cc1O.,COc1ccc(C(=O)NC[C@@H]2CCCC[C@@H]2C[NH3+])cc1O,amide
111072,Modify the molecule O=C(Nc1ccc(-c2nccs2)cc1)c1ccccc1I by removing a halo.,O=C(Nc1ccc(-c2nccs2)cc1)c1ccccc1I,halo
37184,Please remove a amide from the molecule NC(=O)c1ccc(NC(=O)Cc2csc(NC(=O)c3ccsc3)n2)cc1.,NC(=O)c1ccc(NC(=O)Cc2csc(NC(=O)c3ccsc3)n2)cc1,amide
214620,Please remove a benzene_ring from the molecule Cc1ccc(-c2nc3ccccc3c3nnc(S[C@H](C)C(=O)NC[C@@H]4CCCO4)n23)cc1.,Cc1ccc(-c2nc3ccccc3c3nnc(S[C@H](C)C(=O)NC[C@@H]4CCCO4)n23)cc1,benzene_ring
244287,Remove a amide from the molecule Cc1cc(C)n(-c2ccc(N3CCN(C(=O)c4ccc(F)cc4F)CC3)nn2)n1.,Cc1cc(C)n(-c2ccc(N3CCN(C(=O)c4ccc(F)cc4F)CC3)nn2)n1,amide
166148,Remove a amide from the molecule Cc1ccc(NC(=O)C[C@@H](NC(N)=O)c2ccccc2)cc1C(F)(F)F.,Cc1ccc(NC(=O)C[C@@H](NC(N)=O)c2ccccc2)cc1C(F)(F)F,amide
12410,Modify the molecule COc1cccc(NC(=O)[C@@H](NC(=O)c2ccco2)C(C)C)c1 by removing a amide.,COc1cccc(NC(=O)[C@@H](NC(=O)c2ccco2)C(C)C)c1,amide
20057,Remove a benzene_ring from the molecule CCn1cnnc1[C@@H]1CCCN(C(=O)Nc2ccc(OC)cc2)C1.,CCn1cnnc1[C@@H]1CCCN(C(=O)Nc2ccc(OC)cc2)C1,benzene_ring
78415,Please remove a benzene_ring from the molecule O=C(Cc1noc(-c2ccc(-n3ccnn3)cc2)n1)NC1CCCCC1.,O=C(Cc1noc(-c2ccc(-n3ccnn3)cc2)n1)NC1CCCCC1,benzene_ring
26235,Please remove a amide from the molecule CC[NH+](C)CC(=O)NC[C@H]1CN(CC(C)C)CCO1.,CC[NH+](C)CC(=O)NC[C@H]1CN(CC(C)C)CCO1,amide
100052,Please remove a amide from the molecule NC(=O)NC[C@H]1CCCCN1C(=O)CCCC1CCCC1.,NC(=O)NC[C@H]1CCCCN1C(=O)CCCC1CCCC1,amide
205387,Remove a benzene_ring from the molecule O=C(NCCc1cccc(Cl)c1)c1ccc(NS(=O)(=O)c2ccc3[nH]c(=O)[nH]c3c2)cc1.,O=C(NCCc1cccc(Cl)c1)c1ccc(NS(=O)(=O)c2ccc3[nH]c(=O)[nH]c3c2)cc1,benzene_ring
154909,Remove a benzene_ring from the molecule O=C(CCS(=O)(=O)c1ccc2ccccc2c1)N1CCN(Cc2ccccc2F)CC1.,O=C(CCS(=O)(=O)c1ccc2ccccc2c1)N1CCN(Cc2ccccc2F)CC1,benzene_ring
187372,Please remove a benzene_ring from the molecule CSc1cc(C(=O)O[C@@H](C)C(=O)Nc2c(F)cccc2F)ccc1N.,CSc1cc(C(=O)O[C@@H](C)C(=O)Nc2c(F)cccc2F)ccc1N,benzene_ring
89813,Modify the molecule COCCN(Cc1ccco1)C(=O)Nc1ccc(Cl)c([N+](=O)[O-])c1 by removing a nitro.,COCCN(Cc1ccco1)C(=O)Nc1ccc(Cl)c([N+](=O)[O-])c1,nitro
186254,Remove a halo from the molecule CN1CCn2c([nH+]c3cc([N-]S(=O)(=O)c4ccc(Cl)cc4)ccc32)C1.,CN1CCn2c([nH+]c3cc([N-]S(=O)(=O)c4ccc(Cl)cc4)ccc32)C1,halo
113150,Please remove a benzene_ring from the molecule COc1ccc2c(CSc3nnc(-c4ccc(OC(F)F)cc4)o3)cc(=O)oc2c1.,COc1ccc2c(CSc3nnc(-c4ccc(OC(F)F)cc4)o3)cc(=O)oc2c1,benzene_ring
140246,Modify the molecule O=C(NC1CC1)c1ccccc1NC(=O)C1CCOCC1 by removing a amide.,O=C(NC1CC1)c1ccccc1NC(=O)C1CCOCC1,amide
197264,Please remove a benzene_ring from the molecule Cc1c(CCC(=O)N(C)[C@H](C)Cc2ccc(O)cc2)cnn1C.,Cc1c(CCC(=O)N(C)[C@H](C)Cc2ccc(O)cc2)cnn1C,benzene_ring
146645,Remove a amide from the molecule O=C(CN1CCCOC1=O)NCc1nccc2ccccc12.,O=C(CN1CCCOC1=O)NCc1nccc2ccccc12,amide
19003,Modify the molecule CC[NH+](Cc1cccc(C)n1)Cc1cc(C(=O)NN)no1 by removing a amine.,CC[NH+](Cc1cccc(C)n1)Cc1cc(C(=O)NN)no1,amine
56003,Modify the molecule Cc1nn(C)c(C[C@H]([NH3+])[C@@]2(C)CCCO2)c1Cl by removing a halo.,Cc1nn(C)c(C[C@H]([NH3+])[C@@]2(C)CCCO2)c1Cl,halo
240634,Remove a benzene_ring from the molecule CC[C@@H](Oc1cc(Cl)ccc1Cl)C(=O)NNC(=O)[C@H]1[C@@H](C(=O)[O-])[C@H]2CC[C@@H]1C2.,CC[C@@H](Oc1cc(Cl)ccc1Cl)C(=O)NNC(=O)[C@H]1[C@@H](C(=O)[O-])[C@H]2CC[C@@H]1C2,benzene_ring
71679,Please remove a amide from the molecule CCc1nnc(S[C@@H](CC)C(=O)NCc2ccco2)c2cc3occc3n12.,CCc1nnc(S[C@@H](CC)C(=O)NCc2ccco2)c2cc3occc3n12,amide
76198,Remove a benzene_ring from the molecule N#Cc1ccc(CCC(=O)Oc2ccc(Cl)cc2)cc1.,N#Cc1ccc(CCC(=O)Oc2ccc(Cl)cc2)cc1,benzene_ring
172342,Remove a amide from the molecule C[C@H]1OCC[C@H]1C(=O)NCc1ccc(C(=O)NCC[NH+](C)C)cc1.,C[C@H]1OCC[C@H]1C(=O)NCc1ccc(C(=O)NCC[NH+](C)C)cc1,amide
218466,Please remove a benzene_ring from the molecule COc1ccc([C@H]2[C@@H]3SC(=O)N=C3S[C@@H](C(=O)[O-])[C@H]2C(=O)c2ccc3c(c2)CCCC3)cc1.,COc1ccc([C@H]2[C@@H]3SC(=O)N=C3S[C@@H](C(=O)[O-])[C@H]2C(=O)c2ccc3c(c2)CCCC3)cc1,benzene_ring
175871,Modify the molecule Cc1ccc(NC(=O)C2CCC(N3C(=O)[C@H]4[C@H]5CC[C@H](C5)[C@H]4C3=O)CC2)cc1 by removing a amide.,Cc1ccc(NC(=O)C2CCC(N3C(=O)[C@H]4[C@H]5CC[C@H](C5)[C@H]4C3=O)CC2)cc1,amide
186332,Modify the molecule O[C@H]1CCC[C@@H]1C[C@@H]1CCCCO1 by removing a hydroxyl.,O[C@H]1CCC[C@@H]1C[C@@H]1CCCCO1,hydroxyl
148945,Modify the molecule Cc1sc2nc(C[NH+]3CCN(CC(=O)NCCC4=CCCCC4)CC3)[nH]c(=O)c2c1C by removing a amide.,Cc1sc2nc(C[NH+]3CCN(CC(=O)NCCC4=CCCCC4)CC3)[nH]c(=O)c2c1C,amide
199314,Please remove a benzene_ring from the molecule CC[C@@](C)([C@H](N)Cc1cccc(Br)c1)[NH+]1CCCCC1.,CC[C@@](C)([C@H](N)Cc1cccc(Br)c1)[NH+]1CCCCC1,benzene_ring
145517,Please remove a benzene_ring from the molecule Cc1ccccc1-c1c(C2C(C)(C)C2(C)C)noc1N.,Cc1ccccc1-c1c(C2C(C)(C)C2(C)C)noc1N,benzene_ring
99862,Modify the molecule C[C@H]1CC(NC(=O)CSc2nc([O-])c3cnn(-c4cccc(Cl)c4)c3n2)=NO1 by removing a halo.,C[C@H]1CC(NC(=O)CSc2nc([O-])c3cnn(-c4cccc(Cl)c4)c3n2)=NO1,halo
10193,Remove a halo from the molecule Cc1cccc(C(=O)NN2Cc3ccccc3C2)c1F.,Cc1cccc(C(=O)NN2Cc3ccccc3C2)c1F,halo
80795,Please remove a halo from the molecule N#C[C@H](NC(=O)[C@H]1CCOc2ccccc21)c1ccc(Cl)c(Cl)c1.,N#C[C@H](NC(=O)[C@H]1CCOc2ccccc21)c1ccc(Cl)c(Cl)c1,halo
136596,Please remove a amine from the molecule Cc1cc(Cl)ccc1Nc1ncnc(NCc2cccnc2)c1[N+](=O)[O-].,Cc1cc(Cl)ccc1Nc1ncnc(NCc2cccnc2)c1[N+](=O)[O-],amine
55864,Please remove a benzene_ring from the molecule CCC(CC)S(=O)(=O)/N=C(\[O-])c1ccc(N2CCOCC2)c(F)c1.,CCC(CC)S(=O)(=O)/N=C(\[O-])c1ccc(N2CCOCC2)c(F)c1,benzene_ring
42563,Modify the molecule Cc1ccc(NC(=O)C2([NH+](C)C)CCC2)cc1S(C)(=O)=O by removing a benzene_ring.,Cc1ccc(NC(=O)C2([NH+](C)C)CCC2)cc1S(C)(=O)=O,benzene_ring
108756,Modify the molecule N#Cc1csc(C(=O)NCC(=O)OC2CCCCC2)c1 by removing a amide.,N#Cc1csc(C(=O)NCC(=O)OC2CCCCC2)c1,amide
186235,Modify the molecule O=C1NCC=Cc2c1[nH]c(Br)c2Br by removing a halo.,O=C1NCC=Cc2c1[nH]c(Br)c2Br,halo
29878,Modify the molecule CN(C[C@@H]1CCOC1)C(=O)Nc1ccc(Cl)c(CS(C)(=O)=O)c1 by removing a halo.,CN(C[C@@H]1CCOC1)C(=O)Nc1ccc(Cl)c(CS(C)(=O)=O)c1,halo
71341,Modify the molecule Cc1ccccc1C[NH2+]CC1CC[NH2+]CC1 by removing a benzene_ring.,Cc1ccccc1C[NH2+]CC1CC[NH2+]CC1,benzene_ring
80101,Please remove a amide from the molecule CCc1ccc(C(=O)N2CC[C@@H](C)[C@@H](O)C2)cc1.,CCc1ccc(C(=O)N2CC[C@@H](C)[C@@H](O)C2)cc1,amide
222716,Please remove a nitro from the molecule N#C[C@@H]1COCCN1Cc1cc(O)ccc1[N+](=O)[O-].,N#C[C@@H]1COCCN1Cc1cc(O)ccc1[N+](=O)[O-],nitro
2551,Please remove a benzene_ring from the molecule C/[NH+]=C(/NCCc1cc(C)cc(C)c1)NCc1ncc(C)s1.,C/[NH+]=C(/NCCc1cc(C)cc(C)c1)NCc1ncc(C)s1,benzene_ring
158845,Modify the molecule Cc1cccc2nc(C(=O)O[C@@H](C)C(=O)Nc3cccc(C(F)(F)F)c3)cn12 by removing a amide.,Cc1cccc2nc(C(=O)O[C@@H](C)C(=O)Nc3cccc(C(F)(F)F)c3)cn12,amide
234885,Remove a amide from the molecule Cc1noc(C)c1C[NH2+][C@@H](C)C(=O)NC1CCCC1.,Cc1noc(C)c1C[NH2+][C@@H](C)C(=O)NC1CCCC1,amide
184622,Remove a amine from the molecule CC(=O)NCc1ccc(S(=O)(=O)N/N=C/c2cccc([N+](=O)[O-])c2)cc1.,CC(=O)NCc1ccc(S(=O)(=O)N/N=C/c2cccc([N+](=O)[O-])c2)cc1,amine
170640,Modify the molecule COC(=O)[C@@H](C)N1C(=O)S/C(=C/c2ccc(-c3ccccc3C#N)o2)C1=O by removing a nitrile.,COC(=O)[C@@H](C)N1C(=O)S/C(=C/c2ccc(-c3ccccc3C#N)o2)C1=O,nitrile
105704,Remove a halo from the molecule FC(F)(F)CCc1noc(COC2CC[NH2+]CC2)n1.,FC(F)(F)CCc1noc(COC2CC[NH2+]CC2)n1,halo
25719,Modify the molecule C[C@@H](NC(=O)[C@@H](O)c1ccccc1)c1cccc(N2CCOC2=O)c1 by removing a benzene_ring.,C[C@@H](NC(=O)[C@@H](O)c1ccccc1)c1cccc(N2CCOC2=O)c1,benzene_ring
74799,Modify the molecule CCCCN(C)S(=O)(=O)N1CCO[C@H](c2cccc(F)c2)C1 by removing a benzene_ring.,CCCCN(C)S(=O)(=O)N1CCO[C@H](c2cccc(F)c2)C1,benzene_ring
103200,Please remove a benzene_ring from the molecule CCOc1ccc(OCC(=O)Oc2ccc3c4c(c(=O)oc3c2)CCC4)cc1.,CCOc1ccc(OCC(=O)Oc2ccc3c4c(c(=O)oc3c2)CCC4)cc1,benzene_ring
79276,Remove a benzene_ring from the molecule CC(C)c1ccc([C@@H](C)[NH2+]Cc2cnn(C)c2)cc1.,CC(C)c1ccc([C@@H](C)[NH2+]Cc2cnn(C)c2)cc1,benzene_ring
213262,Please remove a amide from the molecule COc1cccc2sc(NC(=O)[C@H](C)OC)nc12.,COc1cccc2sc(NC(=O)[C@H](C)OC)nc12,amide
198391,Remove a benzene_ring from the molecule Cc1ccc([C@H]2CN([C@@H]3CCOC3=O)CCO2)c(C)c1.,Cc1ccc([C@H]2CN([C@@H]3CCOC3=O)CCO2)c(C)c1,benzene_ring
67636,Please remove a amine from the molecule O=S(=O)(NCC[C@H]1C[C@@H]2CC[C@H]1C2)N1CCOCC1.,O=S(=O)(NCC[C@H]1C[C@@H]2CC[C@H]1C2)N1CCOCC1,amine
93279,Modify the molecule Cc1nc(CNc2nc(-c3ccccn3)nc3c2CC[NH+](C)CC3)n[nH]1 by removing a amine.,Cc1nc(CNc2nc(-c3ccccn3)nc3c2CC[NH+](C)CC3)n[nH]1,amine
203995,Modify the molecule COc1ccc(NC(=O)C2=Cc3ccccc3OC2)cc1 by removing a benzene_ring.,COc1ccc(NC(=O)C2=Cc3ccccc3OC2)cc1,benzene_ring
25860,Remove a amide from the molecule O=C1[C@H](c2ccncc2)N(Cc2ccco2)C(=O)CN1c1ccccc1.,O=C1[C@H](c2ccncc2)N(Cc2ccco2)C(=O)CN1c1ccccc1,amide
189903,Remove a amine from the molecule c1cc(CCCNc2ccc(-c3nc(C4CC4)no3)c[nH+]2)ccn1.,c1cc(CCCNc2ccc(-c3nc(C4CC4)no3)c[nH+]2)ccn1,amine
225313,Please remove a hydroxyl from the molecule O=C(NCCC1=CCCCC1)NC[C@@H]1CCC[C@H](O)C1.,O=C(NCCC1=CCCCC1)NC[C@@H]1CCC[C@H](O)C1,hydroxyl
36098,Modify the molecule C[C@@H](SCC1=NC(=O)C2=C(c3ccccc3)CSC2=N1)C(=O)N1CCN(c2nccs2)CC1 by removing a amide.,C[C@@H](SCC1=NC(=O)C2=C(c3ccccc3)CSC2=N1)C(=O)N1CCN(c2nccs2)CC1,amide
48960,Remove a amide from the molecule CC(C)c1nc(C(=O)Nc2ccc3c(c2)OCCO3)n[nH]1.,CC(C)c1nc(C(=O)Nc2ccc3c(c2)OCCO3)n[nH]1,amide
43626,Remove a benzene_ring from the molecule Cc1ccc(OCC[C@@H]2CCC[C@@]2([NH3+])CO)cc1C.,Cc1ccc(OCC[C@@H]2CCC[C@@]2([NH3+])CO)cc1C,benzene_ring
202113,Modify the molecule C[C@@H](NC(=O)C1CCN(c2ccc(N3CCCC3)nn2)CC1)c1ccccc1 by removing a amide.,C[C@@H](NC(=O)C1CCN(c2ccc(N3CCCC3)nn2)CC1)c1ccccc1,amide
9500,Please remove a benzene_ring from the molecule [NH3+][C@@H](Cc1ccc(F)c(Br)c1)c1ccc(Cl)cn1.,[NH3+][C@@H](Cc1ccc(F)c(Br)c1)c1ccc(Cl)cn1,benzene_ring
104937,Remove a amine from the molecule Cc1ccc(CSc2cc(Cl)ccc2N)o1.,Cc1ccc(CSc2cc(Cl)ccc2N)o1,amine
144863,Remove a amide from the molecule C#CCN1CCC(C(=O)N2CCC[C@@H]2c2ccc(C(C)C)cc2)CC1.,C#CCN1CCC(C(=O)N2CCC[C@@H]2c2ccc(C(C)C)cc2)CC1,amide
9214,Remove a amide from the molecule CC(C)CN1CCO[C@@H](CNC(=O)CN2CC[S@@](=O)C(C)(C)C2)C1.,CC(C)CN1CCO[C@@H](CNC(=O)CN2CC[S@@](=O)C(C)(C)C2)C1,amide
66546,Remove a amide from the molecule Cc1ccc2nc(NC(=O)CSc3nnc(Cn4c(=O)sc5ccccc54)n3C)sc2c1.,Cc1ccc2nc(NC(=O)CSc3nnc(Cn4c(=O)sc5ccccc54)n3C)sc2c1,amide
180490,Modify the molecule Cc1ccc(C(=O)Nc2nc(CN3C[C@H](C)O[C@@H](C)C3)cs2)cc1C by removing a benzene_ring.,Cc1ccc(C(=O)Nc2nc(CN3C[C@H](C)O[C@@H](C)C3)cs2)cc1C,benzene_ring
176787,Remove a benzene_ring from the molecule Cc1ccc(O)c(C(=O)Nc2cccc(I)c2)c1.,Cc1ccc(O)c(C(=O)Nc2cccc(I)c2)c1,benzene_ring
160211,Modify the molecule NS(=O)(=O)CCN(CCO)Cc1cc(Br)ccc1F by removing a halo.,NS(=O)(=O)CCN(CCO)Cc1cc(Br)ccc1F,halo
227342,Remove a benzene_ring from the molecule CCCOc1ccccc1NC(=O)C(=O)NC[C@@H]1CCC[C@@H]1O.,CCCOc1ccccc1NC(=O)C(=O)NC[C@@H]1CCC[C@@H]1O,benzene_ring
183295,Modify the molecule COc1ccc(Br)cc1/C=N/N1C(=S)[NH+]=N[C@@H]1c1ccccc1 by removing a halo.,COc1ccc(Br)cc1/C=N/N1C(=S)[NH+]=N[C@@H]1c1ccccc1,halo
37612,Remove a amide from the molecule CCOC(=O)C1CCN(C(=O)CC(F)(F)F)CC1.,CCOC(=O)C1CCN(C(=O)CC(F)(F)F)CC1,amide
125064,Remove a benzene_ring from the molecule CCn1c(=O)c2c(nc3n(-c4ccc(C)c(C)c4)c(C)cn23)n(C)c1=O.,CCn1c(=O)c2c(nc3n(-c4ccc(C)c(C)c4)c(C)cn23)n(C)c1=O,benzene_ring
247757,Please remove a halo from the molecule C[C@H](NC(=O)[C@H](C)Oc1ccccc1C(F)(F)F)C(=O)N(C)C.,C[C@H](NC(=O)[C@H](C)Oc1ccccc1C(F)(F)F)C(=O)N(C)C,halo
10938,Please remove a nitro from the molecule CC[C@@H]1CCc2nc(NC(=O)c3ccc([N+](=O)[O-])o3)sc2C1.,CC[C@@H]1CCc2nc(NC(=O)c3ccc([N+](=O)[O-])o3)sc2C1,nitro
8874,Please remove a benzene_ring from the molecule COCc1ccccc1NC(=O)NC[C@@H](O)c1ccc2ccccc2c1.,COCc1ccccc1NC(=O)NC[C@@H](O)c1ccc2ccccc2c1,benzene_ring
63840,Please remove a benzene_ring from the molecule CNC(=O)[C@H](CC(C)C)NS(=O)(=O)c1ccc(F)cc1C.,CNC(=O)[C@H](CC(C)C)NS(=O)(=O)c1ccc(F)cc1C,benzene_ring
37108,Modify the molecule O=C(NCc1cccnc1OCC(F)(F)F)c1ccc2[nH]cnc2c1 by removing a amide.,O=C(NCc1cccnc1OCC(F)(F)F)c1ccc2[nH]cnc2c1,amide
197490,Remove a amide from the molecule Cc1[nH+]ccn1CCNC(=O)C1(Cc2cccc([C@H]3CCC[NH+](C)C3)c2)CCOCC1.,Cc1[nH+]ccn1CCNC(=O)C1(Cc2cccc([C@H]3CCC[NH+](C)C3)c2)CCOCC1,amide
204463,Please remove a amide from the molecule CC[NH+]1CCC[C@@H]1CN1C[C@H](C(=O)NCc2ccc(C(N)=O)o2)CC1=O.,CC[NH+]1CCC[C@@H]1CN1C[C@H](C(=O)NCc2ccc(C(N)=O)o2)CC1=O,amide
37666,Modify the molecule COC(=O)[C@H](C)NC(=O)c1cnn(-c2cccc(Cl)c2)c1 by removing a benzene_ring.,COC(=O)[C@H](C)NC(=O)c1cnn(-c2cccc(Cl)c2)c1,benzene_ring
64377,Remove a amine from the molecule N#Cc1ccc([C@H]2Nc3ccccc3C(=O)N2Cc2ccc3c(c2)OCO3)cc1.,N#Cc1ccc([C@H]2Nc3ccccc3C(=O)N2Cc2ccc3c(c2)OCO3)cc1,amine
230370,Please remove a benzene_ring from the molecule C[C@@]1(C(=O)Nc2ccc(C#N)cc2)Oc2ccccc2NC1=O.,C[C@@]1(C(=O)Nc2ccc(C#N)cc2)Oc2ccccc2NC1=O,benzene_ring
73090,Modify the molecule CC(C)(C)c1ccc(C(=O)Nc2ccccc2N2CCNC(=O)C2)cc1 by removing a amide.,CC(C)(C)c1ccc(C(=O)Nc2ccccc2N2CCNC(=O)C2)cc1,amide
56170,Remove a amide from the molecule O=C(/C=C/c1ccc(Br)o1)NCCC1=CCCCC1.,O=C(/C=C/c1ccc(Br)o1)NCCC1=CCCCC1,amide
4647,Remove a halo from the molecule O=C(NCCCc1n[nH]c(=O)[nH]1)[C@H]1C[C@@H]1c1c(F)cccc1F.,O=C(NCCCc1n[nH]c(=O)[nH]1)[C@H]1C[C@@H]1c1c(F)cccc1F,halo
147992,Remove a amide from the molecule Cc1cc(C(=O)NCC2CCN(S(=O)(=O)C3CC3)CC2)no1.,Cc1cc(C(=O)NCC2CCN(S(=O)(=O)C3CC3)CC2)no1,amide
184467,Remove a benzene_ring from the molecule COc1cccc(-n2nnc(-c3nc(-c4ccccc4F)no3)c2C)c1.,COc1cccc(-n2nnc(-c3nc(-c4ccccc4F)no3)c2C)c1,benzene_ring
101365,Remove a amide from the molecule Cc1c[nH]c(CN(C)C(=O)[C@@]23CNC[C@@H]2C[NH2+]C3)[nH+]1.,Cc1c[nH]c(CN(C)C(=O)[C@@]23CNC[C@@H]2C[NH2+]C3)[nH+]1,amide
211205,Remove a hydroxyl from the molecule CSc1ccc(C(=O)[C@@H]2CCC[NH+](Cc3ccc(C#CC(C)(C)O)s3)C2)cc1.,CSc1ccc(C(=O)[C@@H]2CCC[NH+](Cc3ccc(C#CC(C)(C)O)s3)C2)cc1,hydroxyl
72154,Remove a amide from the molecule C[C@H]1C[C@@H](C)CN(C(=O)C[NH+](C)CC2CC[NH2+]CC2)C1.,C[C@H]1C[C@@H](C)CN(C(=O)C[NH+](C)CC2CC[NH2+]CC2)C1,amide
133732,Please remove a amide from the molecule COc1cc2c(cc1OC)CN(C(=O)CSc1nnc([C@@H]3COc4ccccc4O3)n1C)CC2.,COc1cc2c(cc1OC)CN(C(=O)CSc1nnc([C@@H]3COc4ccccc4O3)n1C)CC2,amide
4182,Remove a amide from the molecule COCCNC(=O)[C@@H](C)CS(=O)(=O)c1ccc(Br)cc1.,COCCNC(=O)[C@@H](C)CS(=O)(=O)c1ccc(Br)cc1,amide
186229,Remove a benzene_ring from the molecule CNC(=O)c1ccc(OC)c(NC(=O)NCc2cccnc2)c1.,CNC(=O)c1ccc(OC)c(NC(=O)NCc2cccnc2)c1,benzene_ring
227697,Remove a benzene_ring from the molecule NC(=O)C[C@H](C(=O)[O-])N1C(=O)/C(=C/c2ccccc2)SC1=S.,NC(=O)C[C@H](C(=O)[O-])N1C(=O)/C(=C/c2ccccc2)SC1=S,benzene_ring
125324,Please remove a amide from the molecule COc1ccc(C)c2sc(N(CC[NH+](C)C)C(=O)c3snnc3C)nc12.,COc1ccc(C)c2sc(N(CC[NH+](C)C)C(=O)c3snnc3C)nc12,amide
11662,Modify the molecule COc1ccc(O[C@H](C)C(=O)Nc2ccnn2Cc2ccc(C)cc2)cc1 by removing a benzene_ring.,COc1ccc(O[C@H](C)C(=O)Nc2ccnn2Cc2ccc(C)cc2)cc1,benzene_ring
242029,Please remove a amide from the molecule Cc1ccc(Cc2nnc(NC(=O)[C@H]3CCCCN3S(=O)(=O)c3cccs3)o2)cc1C.,Cc1ccc(Cc2nnc(NC(=O)[C@H]3CCCCN3S(=O)(=O)c3cccs3)o2)cc1C,amide
194066,Modify the molecule CCc1nnc2ccc(S(=O)(=O)N(CC)c3ccccc3)cn12 by removing a benzene_ring.,CCc1nnc2ccc(S(=O)(=O)N(CC)c3ccccc3)cn12,benzene_ring
242130,Remove a amide from the molecule CC[C@H](Sc1nnc(-c2cccc(N)c2)n1C)C(=O)Nc1ccc(Br)cc1.,CC[C@H](Sc1nnc(-c2cccc(N)c2)n1C)C(=O)Nc1ccc(Br)cc1,amide
81715,Modify the molecule CCS(=O)(=O)CCNC(=O)N[C@@H](c1ccccc1)c1ccccn1 by removing a benzene_ring.,CCS(=O)(=O)CCNC(=O)N[C@@H](c1ccccc1)c1ccccn1,benzene_ring
22335,Please remove a amide from the molecule Cn1cc(CCC(=O)Nc2cc(-c3ccncc3)n[nH]2)cn1.,Cn1cc(CCC(=O)Nc2cc(-c3ccncc3)n[nH]2)cn1,amide
153544,Modify the molecule CCC[C@H]1C[NH2+]CC[C@@H]1c1ccc(OC)cc1 by removing a benzene_ring.,CCC[C@H]1C[NH2+]CC[C@@H]1c1ccc(OC)cc1,benzene_ring
86357,Modify the molecule C[C@H](CC(=O)N1CCC([C@@H]2Nc3ccccc3S(=O)(=O)N2)CC1)n1cncn1 by removing a amine.,C[C@H](CC(=O)N1CCC([C@@H]2Nc3ccccc3S(=O)(=O)N2)CC1)n1cncn1,amine
115435,Please remove a amide from the molecule CCOC(=O)[C@H]1CCCN(C(=O)c2ccc(C)nc2)C1.,CCOC(=O)[C@H]1CCCN(C(=O)c2ccc(C)nc2)C1,amide
208864,Modify the molecule COCCN(C(C)=O)c1nc(Cn2nc(C(C)(C)C)ccc2=O)cs1 by removing a amide.,COCCN(C(C)=O)c1nc(Cn2nc(C(C)(C)C)ccc2=O)cs1,amide
49553,Modify the molecule Cn1cc(C(=O)N2CCCCC2)cc(NC(=O)c2cc(=O)c3ccccc3o2)c1=O by removing a amide.,Cn1cc(C(=O)N2CCCCC2)cc(NC(=O)c2cc(=O)c3ccccc3o2)c1=O,amide
131279,Please remove a halo from the molecule Cc1nc(CN2CCN(c3ncc(Cl)cc3Cl)CC2)no1.,Cc1nc(CN2CCN(c3ncc(Cl)cc3Cl)CC2)no1,halo
185226,Remove a halo from the molecule COc1ccc(Br)cc1CNC(=O)CCl.,COc1ccc(Br)cc1CNC(=O)CCl,halo
188342,Modify the molecule O=C(NCc1cccnc1)C(F)(F)F by removing a amide.,O=C(NCc1cccnc1)C(F)(F)F,amide
164491,Remove a amide from the molecule C[C@@H](O)C[NH+]1CCC2(CCC(=O)N(Cc3ccccc3)C2)CC1.,C[C@@H](O)C[NH+]1CCC2(CCC(=O)N(Cc3ccccc3)C2)CC1,amide
120556,Remove a benzene_ring from the molecule O=C(c1cnns1)N1CCC[C@@H]1c1cccc(Br)c1.,O=C(c1cnns1)N1CCC[C@@H]1c1cccc(Br)c1,benzene_ring
7538,Modify the molecule Cc1ccc(NC(=O)N2CCC[C@H](c3nnc(C(=O)Nc4ccc(F)cc4)s3)C2)c(C)c1 by removing a amide.,Cc1ccc(NC(=O)N2CCC[C@H](c3nnc(C(=O)Nc4ccc(F)cc4)s3)C2)c(C)c1,amide
38125,Remove a amide from the molecule O=C1N[C@@H](/C=C/c2ccco2)N2CCOC[C@H]12.,O=C1N[C@@H](/C=C/c2ccco2)N2CCOC[C@H]12,amide
141609,Remove a halo from the molecule Cc1c(O)n[nH]c1C(=O)NN=Cc1ccc(Cl)cc1Cl.,Cc1c(O)n[nH]c1C(=O)NN=Cc1ccc(Cl)cc1Cl,halo
10616,Modify the molecule FC(F)(F)c1cnn(-c2nc(Br)cs2)c1 by removing a halo.,FC(F)(F)c1cnn(-c2nc(Br)cs2)c1,halo
54449,Remove a benzene_ring from the molecule C[S@](=O)c1ccc(CNC(=O)CCc2c(F)cccc2F)cc1.,C[S@](=O)c1ccc(CNC(=O)CCc2c(F)cccc2F)cc1,benzene_ring
3807,Remove a amide from the molecule Cn1ccnc1SCC(=O)N1CCC(C(=O)N2CCCCCC2)CC1.,Cn1ccnc1SCC(=O)N1CCC(C(=O)N2CCCCCC2)CC1,amide
189280,Modify the molecule COc1ccccc1C[NH2+]CC[C@H]1CCCO1 by removing a benzene_ring.,COc1ccccc1C[NH2+]CC[C@H]1CCCO1,benzene_ring
152411,Remove a nitrile from the molecule CN[C@]1(C#N)CCC[C@@H]1CC[NH+]1CC[C@@H]2CCCC[C@@H]2C1.,CN[C@]1(C#N)CCC[C@@H]1CC[NH+]1CC[C@@H]2CCCC[C@@H]2C1,nitrile
174031,Please remove a halo from the molecule O=C(NCc1cccn1Cc1cccc(F)c1)Nc1ccccc1C(F)(F)F.,O=C(NCc1cccn1Cc1cccc(F)c1)Nc1ccccc1C(F)(F)F,halo
32186,Modify the molecule CCN1CCO[C@H](c2nc(-c3cccc(C[NH3+])c3)cs2)C1 by removing a benzene_ring.,CCN1CCO[C@H](c2nc(-c3cccc(C[NH3+])c3)cs2)C1,benzene_ring
87977,Modify the molecule Cc1cc(CSc2ncccc2C(=O)Nc2ccc3oc(C)nc3c2)no1 by removing a amide.,Cc1cc(CSc2ncccc2C(=O)Nc2ccc3oc(C)nc3c2)no1,amide
221747,Modify the molecule NC(=O)[C@@H](CNC(=O)c1cc(F)ccc1O)Cc1ccc(F)cc1 by removing a benzene_ring.,NC(=O)[C@@H](CNC(=O)c1cc(F)ccc1O)Cc1ccc(F)cc1,benzene_ring
213468,Remove a amide from the molecule CCS[C@H]1CCCCN(C(=O)[C@H](C)Sc2ccccn2)C1.,CCS[C@H]1CCCCN(C(=O)[C@H](C)Sc2ccccn2)C1,amide
202846,Modify the molecule CCCC(=O)Nc1cccc(NC(=O)N(CC)C[C@H](C)C#N)c1 by removing a nitrile.,CCCC(=O)Nc1cccc(NC(=O)N(CC)C[C@H](C)C#N)c1,nitrile
27706,Please remove a halo from the molecule C[C@H]1C[C@@H](N2CCN(c3cccc(Cl)c3)CC2)C(=O)O1.,C[C@H]1C[C@@H](N2CCN(c3cccc(Cl)c3)CC2)C(=O)O1,halo
101320,Please remove a amide from the molecule O=C(CSc1nnc(Cc2cc(=O)[nH]c(=O)[nH]2)n1-c1ccc(Cl)cc1)Nc1ccccc1.,O=C(CSc1nnc(Cc2cc(=O)[nH]c(=O)[nH]2)n1-c1ccc(Cl)cc1)Nc1ccccc1,amide
175845,Remove a amide from the molecule C[C@H](C(=O)Nc1ccc2c(c1)OCO2)N(Cc1cccnc1)C(=O)Cn1nnc2ccccc21.,C[C@H](C(=O)Nc1ccc2c(c1)OCO2)N(Cc1cccnc1)C(=O)Cn1nnc2ccccc21,amide
79738,Please remove a hydroxyl from the molecule O/N=C1/CCCN(Cc2ccccc2)C1.,O/N=C1/CCCN(Cc2ccccc2)C1,hydroxyl
19537,Please remove a amide from the molecule Cc1ccc(C(=O)NNC(=O)Cc2ccc(-c3ccccc3)cc2)o1.,Cc1ccc(C(=O)NNC(=O)Cc2ccc(-c3ccccc3)cc2)o1,amide
54221,Remove a benzene_ring from the molecule COc1cccc(F)c1[C@H](C)NC(=O)NCC[NH+]1CCC(OC)CC1.,COc1cccc(F)c1[C@H](C)NC(=O)NCC[NH+]1CCC(OC)CC1,benzene_ring
48367,Please remove a amide from the molecule O=C(Cc1ccncc1)NNC(=O)N[C@@H]1CCCC[C@H]1Cc1ccccc1.,O=C(Cc1ccncc1)NNC(=O)N[C@@H]1CCCC[C@H]1Cc1ccccc1,amide
54500,Modify the molecule Cn1c(C[NH+]2CCCCC2)nc2cc(NS(=O)(=O)c3ccc(Cl)cc3)ccc21 by removing a halo.,Cn1c(C[NH+]2CCCCC2)nc2cc(NS(=O)(=O)c3ccc(Cl)cc3)ccc21,halo
127918,Modify the molecule CCn1ccnc1SCc1cccc(NC(=O)OC(C)(C)C)c1 by removing a benzene_ring.,CCn1ccnc1SCc1cccc(NC(=O)OC(C)(C)C)c1,benzene_ring
74,Remove a benzene_ring from the molecule COc1cccc(CN2CCc3nnc(CCc4ccccc4)n3CC2)c1.,COc1cccc(CN2CCc3nnc(CCc4ccccc4)n3CC2)c1,benzene_ring
34562,Please remove a benzene_ring from the molecule C[NH2+]Cc1cc(C)n(-c2ccc(OC)cc2)c1C.,C[NH2+]Cc1cc(C)n(-c2ccc(OC)cc2)c1C,benzene_ring
68048,Please remove a benzene_ring from the molecule COc1cn(-c2ccccc2)nc1C(=O)OCC(=O)N1CCCCC1.,COc1cn(-c2ccccc2)nc1C(=O)OCC(=O)N1CCCCC1,benzene_ring
88185,Modify the molecule COCCn1ccc2ccc(NC(=O)c3cccc(-n4cnnn4)c3)cc21 by removing a amide.,COCCn1ccc2ccc(NC(=O)c3cccc(-n4cnnn4)c3)cc21,amide
88597,Please remove a benzene_ring from the molecule O=C(NCC[NH+]1CCC(c2ccsc2)CC1)c1ccc(F)cc1Cl.,O=C(NCC[NH+]1CCC(c2ccsc2)CC1)c1ccc(F)cc1Cl,benzene_ring
82720,Modify the molecule C[C@H](N[C@@H]1N=NC(=O)NC1=O)C(=O)N/N=C/c1ccc(Cl)cc1Cl by removing a benzene_ring.,C[C@H](N[C@@H]1N=NC(=O)NC1=O)C(=O)N/N=C/c1ccc(Cl)cc1Cl,benzene_ring
223533,Remove a amide from the molecule C[C@H](NC(=O)CCn1ccccc1=O)C(=O)[O-].,C[C@H](NC(=O)CCn1ccccc1=O)C(=O)[O-],amide
197619,Remove a benzene_ring from the molecule CC1CCN(C(=O)[C@@H](C)Sc2nnnn2Cc2ccccc2)CC1.,CC1CCN(C(=O)[C@@H](C)Sc2nnnn2Cc2ccccc2)CC1,benzene_ring
241653,Modify the molecule NC(=S)c1c(F)cccc1-n1cnc2ccccc21 by removing a amine.,NC(=S)c1c(F)cccc1-n1cnc2ccccc21,amine
84799,Modify the molecule COc1ccccc1[C@H](C)NC(=O)[C@H](C)SCC(C)C by removing a benzene_ring.,COc1ccccc1[C@H](C)NC(=O)[C@H](C)SCC(C)C,benzene_ring
109940,Please remove a benzene_ring from the molecule [NH3+]CC(=O)N1CCCC[C@@H]1CNC(=O)OCc1ccccc1.,[NH3+]CC(=O)N1CCCC[C@@H]1CNC(=O)OCc1ccccc1,benzene_ring
202606,Remove a halo from the molecule O=[N+]([O-])c1cc(Br)ccc1N1CC[C@H](O)C1.,O=[N+]([O-])c1cc(Br)ccc1N1CC[C@H](O)C1,halo
47089,Modify the molecule C[C@H](Sc1nccn1-c1cccc(F)c1)C(=O)Nc1ccc2c(c1)OCCO2 by removing a halo.,C[C@H](Sc1nccn1-c1cccc(F)c1)C(=O)Nc1ccc2c(c1)OCCO2,halo
103784,Modify the molecule C[C@@H](C(=O)N[C@H](C)c1ccc(S(N)(=O)=O)cc1)[NH+]1CCC(C)(C)C1 by removing a benzene_ring.,C[C@@H](C(=O)N[C@H](C)c1ccc(S(N)(=O)=O)cc1)[NH+]1CCC(C)(C)C1,benzene_ring
97248,Please remove a benzene_ring from the molecule NC(=O)N1CCC[C@H](C(=O)Nc2cccc(-c3nc4ccccc4s3)c2)C1.,NC(=O)N1CCC[C@H](C(=O)Nc2cccc(-c3nc4ccccc4s3)c2)C1,benzene_ring
9096,Remove a amide from the molecule CCOC(=O)[C@]12C(=C(c3ccccc3)O[C@@H]3C=CCC[C@H]31)C(=O)C(=O)N2c1ccccc1.,CCOC(=O)[C@]12C(=C(c3ccccc3)O[C@@H]3C=CCC[C@H]31)C(=O)C(=O)N2c1ccccc1,amide
124374,Remove a amide from the molecule CCC(=O)Nc1ccc(N2CCN(Cc3nc4ccccc4n3C)CC2)c(Cl)c1.,CCC(=O)Nc1ccc(N2CCN(Cc3nc4ccccc4n3C)CC2)c(Cl)c1,amide
161325,Remove a benzene_ring from the molecule Cc1ccc(C(=O)N2CCN(C(=O)Nc3cccc(C)c3)CC2)cc1.,Cc1ccc(C(=O)N2CCN(C(=O)Nc3cccc(C)c3)CC2)cc1,benzene_ring
58330,Please remove a halo from the molecule CC[NH2+][C@@H](c1ccc(F)c(F)c1)[C@H](C)OC.,CC[NH2+][C@@H](c1ccc(F)c(F)c1)[C@H](C)OC,halo
62029,Please remove a amide from the molecule COc1ccc([C@@H]2SCC(=O)N2c2ccccc2)cc1OC.,COc1ccc([C@@H]2SCC(=O)N2c2ccccc2)cc1OC,amide
27869,Please remove a amide from the molecule CC(C)CCNC(=O)[C@@H](NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2c3ccccc3C(=O)N12)C(C)C.,CC(C)CCNC(=O)[C@@H](NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2c3ccccc3C(=O)N12)C(C)C,amide
129334,Modify the molecule O=C(NC[C@H]1COc2ccccc2O1)c1cc(-c2ccco2)nn1-c1ccccc1 by removing a benzene_ring.,O=C(NC[C@H]1COc2ccccc2O1)c1cc(-c2ccco2)nn1-c1ccccc1,benzene_ring
30862,Modify the molecule COc1ccc(NC(=O)[C@@H](C)Cc2ccccc2F)c(C)c1 by removing a amide.,COc1ccc(NC(=O)[C@@H](C)Cc2ccccc2F)c(C)c1,amide
90983,Modify the molecule CCNS(=O)(=O)[C@H]1CCN(C(=O)[C@H]2C[C@@H]2c2sccc2C)C1 by removing a amine.,CCNS(=O)(=O)[C@H]1CCN(C(=O)[C@H]2C[C@@H]2c2sccc2C)C1,amine
122393,Remove a benzene_ring from the molecule CC[C@H](NC(=O)N1CC=C(c2cccc(C)c2)CC1)c1ccncc1.,CC[C@H](NC(=O)N1CC=C(c2cccc(C)c2)CC1)c1ccncc1,benzene_ring
164909,Please remove a benzene_ring from the molecule Cc1cc(Br)cc([N+](=O)[O-])c1O[C@@H]1CC(=O)C12CCCC2.,Cc1cc(Br)cc([N+](=O)[O-])c1O[C@@H]1CC(=O)C12CCCC2,benzene_ring
174284,Please remove a benzene_ring from the molecule COC(=O)[C@H]1CCC[C@H]1NC(=O)Nc1ccc(F)c(C)c1.,COC(=O)[C@H]1CCC[C@H]1NC(=O)Nc1ccc(F)c(C)c1,benzene_ring
10883,Remove a benzene_ring from the molecule Cc1ccc(CCC(=O)N[C@@H](c2ccccc2)c2ccncc2)cc1.,Cc1ccc(CCC(=O)N[C@@H](c2ccccc2)c2ccncc2)cc1,benzene_ring
195832,Please remove a amine from the molecule C#CCN/C(NCC(C)(C)[NH+]1CCCCC1)=[NH+]/CC.,C#CCN/C(NCC(C)(C)[NH+]1CCCCC1)=[NH+]/CC,amine
99379,Modify the molecule O=C1NC(=S)NC(=O)C1=CNCCc1ccc(F)cc1 by removing a benzene_ring.,O=C1NC(=S)NC(=O)C1=CNCCc1ccc(F)cc1,benzene_ring
7318,Remove a amide from the molecule O=C(COC1CCCCC1)NC1CC[NH+](CCc2ccncc2)CC1.,O=C(COC1CCCCC1)NC1CC[NH+](CCc2ccncc2)CC1,amide
99537,Modify the molecule O=C(Nc1cnc2ccccc2n1)c1cc2c([nH]c1=O)CCCC2 by removing a amide.,O=C(Nc1cnc2ccccc2n1)c1cc2c([nH]c1=O)CCCC2,amide
108791,Remove a benzene_ring from the molecule CCOc1ccc(Nc2nc(-c3cccs3)c(CC(=O)[O-])s2)cc1.,CCOc1ccc(Nc2nc(-c3cccs3)c(CC(=O)[O-])s2)cc1,benzene_ring
32658,Please remove a benzene_ring from the molecule CC[C@H](Oc1ccccc1)C(=O)Nc1cccc(C(=O)Nc2ccccc2)c1.,CC[C@H](Oc1ccccc1)C(=O)Nc1cccc(C(=O)Nc2ccccc2)c1,benzene_ring
207471,Please remove a halo from the molecule O=S(=O)([N-]c1nc2ccccc2nc1Cl)c1ccc2ccccc2c1.,O=S(=O)([N-]c1nc2ccccc2nc1Cl)c1ccc2ccccc2c1,halo
72889,Remove a amine from the molecule Cc1nnc2ccc(N[C@H](C)C(=O)N3CCOCC3)nn12.,Cc1nnc2ccc(N[C@H](C)C(=O)N3CCOCC3)nn12,amine
92841,Modify the molecule CC[C@@H](C(=O)NNC(=O)N[C@@H](c1ccccn1)C(C)C)c1ccccc1 by removing a benzene_ring.,CC[C@@H](C(=O)NNC(=O)N[C@@H](c1ccccn1)C(C)C)c1ccccc1,benzene_ring
247401,Remove a hydroxyl from the molecule Cc1csc(C[C@H](O)Cc2nccs2)n1.,Cc1csc(C[C@H](O)Cc2nccs2)n1,hydroxyl
134402,Please remove a amide from the molecule COc1ccc(/C=N/NC(=O)CC#N)cc1Br.,COc1ccc(/C=N/NC(=O)CC#N)cc1Br,amide
127995,Please remove a amide from the molecule C=CCNC(=O)NC(=O)CN1CCOC[C@@H]1C1CC1.,C=CCNC(=O)NC(=O)CN1CCOC[C@@H]1C1CC1,amide
19903,Modify the molecule CCOc1ccc([N-]S(=O)(=O)[C@H]2C(C)=NC(C)=C2C(=O)N2CCCCC2)cc1 by removing a amide.,CCOc1ccc([N-]S(=O)(=O)[C@H]2C(C)=NC(C)=C2C(=O)N2CCCCC2)cc1,amide
96766,Modify the molecule CCn1c(C)cc(C(=O)Nc2ccc(N3C(=O)CCCC3=O)cc2)c1C by removing a benzene_ring.,CCn1c(C)cc(C(=O)Nc2ccc(N3C(=O)CCCC3=O)cc2)c1C,benzene_ring
224389,Remove a amide from the molecule CC(C)[NH+]1CCC(C(=O)Nc2nnc(C(F)(F)F)s2)CC1.,CC(C)[NH+]1CCC(C(=O)Nc2nnc(C(F)(F)F)s2)CC1,amide
114051,Please remove a benzene_ring from the molecule CC[C@H](CC1CCCC1)C(=O)Nc1cc(C(=O)N(C)C)ccc1C.,CC[C@H](CC1CCCC1)C(=O)Nc1cc(C(=O)N(C)C)ccc1C,benzene_ring
9827,Please remove a benzene_ring from the molecule O=C1C[C@@H](C(=O)N2CCC[C@@H](O)C2)CN1CCc1ccccc1.,O=C1C[C@@H](C(=O)N2CCC[C@@H](O)C2)CN1CCc1ccccc1,benzene_ring
159867,Remove a amine from the molecule CN1CCO[C@H](COc2ccc(CC(N)=S)cc2)C1.,CN1CCO[C@H](COc2ccc(CC(N)=S)cc2)C1,amine
101667,Please remove a benzene_ring from the molecule C=CCOc1cccc(NC(=O)[C@@H](C)Oc2cccc(C)c2)c1.,C=CCOc1cccc(NC(=O)[C@@H](C)Oc2cccc(C)c2)c1,benzene_ring
95953,Please remove a benzene_ring from the molecule Cc1nc2c(-c3cccs3)nc(=O)n(Cc3ccc(Cl)cc3Cl)c2s1.,Cc1nc2c(-c3cccs3)nc(=O)n(Cc3ccc(Cl)cc3Cl)c2s1,benzene_ring
170399,Remove a halo from the molecule COc1ccc([C@@H]2[C@@H](C(=O)Nc3cc(Cl)ccc3OC)c3ccccc3C(=O)N2C)cc1.,COc1ccc([C@@H]2[C@@H](C(=O)Nc3cc(Cl)ccc3OC)c3ccccc3C(=O)N2C)cc1,halo
90796,Remove a benzene_ring from the molecule C[C@H]1CN(C2=NC(=O)/C(=C\c3ccc4noc(-c5ccccc5)c4c3)S2)C[C@@H](C)O1.,C[C@H]1CN(C2=NC(=O)/C(=C\c3ccc4noc(-c5ccccc5)c4c3)S2)C[C@@H](C)O1,benzene_ring
130924,Please remove a amide from the molecule Cn1c(-c2ccccn2)nn(CCNC(=O)c2ccco2)c1=O.,Cn1c(-c2ccccn2)nn(CCNC(=O)c2ccco2)c1=O,amide
234008,Modify the molecule COC(=O)c1ncn2c1C(=O)N(c1ccc(C)c(F)c1)[C@](C)(C(=O)NCc1ccccc1OC)C2 by removing a benzene_ring.,COC(=O)c1ncn2c1C(=O)N(c1ccc(C)c(F)c1)[C@](C)(C(=O)NCc1ccccc1OC)C2,benzene_ring
195696,Modify the molecule CC(=O)OC1=C(C(C)=O)N(C(C)=O)S(=O)(=O)c2ccccc21 by removing a amide.,CC(=O)OC1=C(C(C)=O)N(C(C)=O)S(=O)(=O)c2ccccc21,amide
52539,Remove a hydroxyl from the molecule Cc1c(C[NH2+][C@H]2CCC[C@@H](O)C2)cnn1C.,Cc1c(C[NH2+][C@H]2CCC[C@@H](O)C2)cnn1C,hydroxyl
182665,Remove a halo from the molecule COc1ccc(CN2CC[C@H]3[C@H](CCC[NH+]3C3CC3)C2)cc1OC(F)F.,COc1ccc(CN2CC[C@H]3[C@H](CCC[NH+]3C3CC3)C2)cc1OC(F)F,halo
241223,Remove a benzene_ring from the molecule C[C@H](CN(C)C(=O)N[C@@H]1CC[NH+](C2CCCC2)C1)c1ccccc1.,C[C@H](CN(C)C(=O)N[C@@H]1CC[NH+](C2CCCC2)C1)c1ccccc1,benzene_ring
136295,Modify the molecule CC(C)Oc1ccc(CCNC(=O)N[C@@H](C)CO)cc1 by removing a hydroxyl.,CC(C)Oc1ccc(CCNC(=O)N[C@@H](C)CO)cc1,hydroxyl
213485,Remove a amide from the molecule Cc1noc(C(C)C)c1C(=O)N1CCC[C@H]([NH+]2CCCC2)C1.,Cc1noc(C(C)C)c1C(=O)N1CCC[C@H]([NH+]2CCCC2)C1,amide
219843,Please remove a amine from the molecule Cc1nn(C)c(C)c1NC(=S)NCc1cccnc1.,Cc1nn(C)c(C)c1NC(=S)NCc1cccnc1,amine
104192,Modify the molecule [NH3+][C@H]1CCC[C@H](Nc2cccc(-c3cnco3)c2)C1 by removing a benzene_ring.,[NH3+][C@H]1CCC[C@H](Nc2cccc(-c3cnco3)c2)C1,benzene_ring
122996,Modify the molecule COc1ccccc1OC(=O)CCc1c(C)nc(-c2cccnc2)[nH]c1=O by removing a benzene_ring.,COc1ccccc1OC(=O)CCc1c(C)nc(-c2cccnc2)[nH]c1=O,benzene_ring
237916,Remove a benzene_ring from the molecule CCOC(=O)[C@H](C)Sc1ccc(N)c(C)c1.,CCOC(=O)[C@H](C)Sc1ccc(N)c(C)c1,benzene_ring
217716,Please remove a amide from the molecule CO[C@@H]1CCCC[C@H]1NC(=O)/C=C/c1cnc(C(C)(C)C)s1.,CO[C@@H]1CCCC[C@H]1NC(=O)/C=C/c1cnc(C(C)(C)C)s1,amide
105227,Remove a amide from the molecule CCOc1ccc(S(=O)(=O)N2CCC[C@@H](CNC(C)=O)C2)c2ccccc12.,CCOc1ccc(S(=O)(=O)N2CCC[C@@H](CNC(C)=O)C2)c2ccccc12,amide
8226,Modify the molecule O=C1C[C@H](C(=O)NCCC2=CCCCC2)Cc2nc(NC(=O)c3c(F)cccc3Cl)sc21 by removing a benzene_ring.,O=C1C[C@H](C(=O)NCCC2=CCCCC2)Cc2nc(NC(=O)c3c(F)cccc3Cl)sc21,benzene_ring
73769,Remove a amide from the molecule Cc1ccc(NC(=O)CSc2nnc3c(Cl)cc(C(F)(F)F)cn23)c(Cl)c1.,Cc1ccc(NC(=O)CSc2nnc3c(Cl)cc(C(F)(F)F)cn23)c(Cl)c1,amide
136004,Please remove a amide from the molecule CCn1cc(C(=O)N(CCc2cccs2)Cc2cccnc2)c(=O)c2ccc(C)nc21.,CCn1cc(C(=O)N(CCc2cccs2)Cc2cccnc2)c(=O)c2ccc(C)nc21,amide
216569,Please remove a benzene_ring from the molecule CC(C)n1nccc1NC(=O)COc1cc(F)ccc1F.,CC(C)n1nccc1NC(=O)COc1cc(F)ccc1F,benzene_ring
205850,Remove a halo from the molecule O=C(C1CCC1)N1C[C@@H]2CC[C@H](C1)N(C(=O)c1cc(Cl)ccc1O)C2.,O=C(C1CCC1)N1C[C@@H]2CC[C@H](C1)N(C(=O)c1cc(Cl)ccc1O)C2,halo
220352,Modify the molecule O=C(NCCc1cc(F)cc2c1OCOC2)NC[C@@H]1CCCO1 by removing a halo.,O=C(NCCc1cc(F)cc2c1OCOC2)NC[C@@H]1CCCO1,halo
120590,Remove a amine from the molecule Cc1c(C(=O)N2CCCCC2)c(S(=O)(=O)NCc2ccc3c(c2)OCO3)c(C)n1C.,Cc1c(C(=O)N2CCCCC2)c(S(=O)(=O)NCc2ccc3c(c2)OCO3)c(C)n1C,amine
140231,Please remove a halo from the molecule Cc1cc(N2CCN(C(=O)c3ccc(Cl)s3)CC2)cc(C)[nH+]1.,Cc1cc(N2CCN(C(=O)c3ccc(Cl)s3)CC2)cc(C)[nH+]1,halo
228884,Please remove a amide from the molecule CN(/C([O-])=N/c1ncnn1C)[C@@H]1CCCN(c2ccccc2)C1=O.,CN(/C([O-])=N/c1ncnn1C)[C@@H]1CCCN(c2ccccc2)C1=O,amide
113513,Please remove a benzene_ring from the molecule CCc1c(C[NH2+]CC(C)C)cnn1-c1ccccc1Br.,CCc1c(C[NH2+]CC(C)C)cnn1-c1ccccc1Br,benzene_ring
226519,Please remove a halo from the molecule CCC1=NN(C(=O)c2ccc(F)cc2)[C@@](O)(C(F)(F)F)C1.,CCC1=NN(C(=O)c2ccc(F)cc2)[C@@](O)(C(F)(F)F)C1,halo
157314,Remove a benzene_ring from the molecule CCc1nc(-c2cccc(OC)c2)nc(CC)c1CC[NH3+].,CCc1nc(-c2cccc(OC)c2)nc(CC)c1CC[NH3+],benzene_ring
193531,Remove a amide from the molecule COCC[S@](=O)[C@H](C)C(=O)Nc1ccc(F)c(Cl)c1.,COCC[S@](=O)[C@H](C)C(=O)Nc1ccc(F)c(Cl)c1,amide
171337,Remove a amide from the molecule COc1ccc(OC)c2sc(N(Cc3cccnc3)C(=O)c3c[nH]c4ccccc34)nc12.,COc1ccc(OC)c2sc(N(Cc3cccnc3)C(=O)c3c[nH]c4ccccc34)nc12,amide
51563,Modify the molecule CCS(=O)(=O)N[C@H](C)CCc1ccccc1 by removing a amine.,CCS(=O)(=O)N[C@H](C)CCc1ccccc1,amine
50236,Remove a benzene_ring from the molecule COc1ccc(-n2nc(C(=O)N3CCC([C@@H](C)O)CC3)cc2C)cc1.,COc1ccc(-n2nc(C(=O)N3CCC([C@@H](C)O)CC3)cc2C)cc1,benzene_ring
100931,Please remove a amide from the molecule C[C@@H]1CCCC[C@H]1NC(=O)Cc1coc2cc3c(cc12)CCC3.,C[C@@H]1CCCC[C@H]1NC(=O)Cc1coc2cc3c(cc12)CCC3,amide
178416,Modify the molecule C[C@H]1C[C@H]1C(=O)OCC(=O)Nc1cc(S(C)(=O)=O)ccc1Cl by removing a halo.,C[C@H]1C[C@H]1C(=O)OCC(=O)Nc1cc(S(C)(=O)=O)ccc1Cl,halo
136775,Please remove a amide from the molecule CNC(=O)c1cccc(NC(=O)C(=O)N[C@H]2CC[C@@H]([NH+](C)C)C2)c1C.,CNC(=O)c1cccc(NC(=O)C(=O)N[C@H]2CC[C@@H]([NH+](C)C)C2)c1C,amide
203006,Remove a nitro from the molecule CC(C)c1cc(C(=O)NNC(=O)c2cccc([N+](=O)[O-])c2)nn1C.,CC(C)c1cc(C(=O)NNC(=O)c2cccc([N+](=O)[O-])c2)nn1C,nitro
90270,Please remove a amide from the molecule Cc1ccncc1[N-]S(=O)(=O)c1c[nH]c(C(=O)N2CCCC2)c1.,Cc1ccncc1[N-]S(=O)(=O)c1c[nH]c(C(=O)N2CCCC2)c1,amide
52898,Remove a hydroxyl from the molecule CCC[NH+]1CCN([C@H]2CC[C@@](CO)([NH2+]C(C)C)C2)CC1.,CCC[NH+]1CCN([C@H]2CC[C@@](CO)([NH2+]C(C)C)C2)CC1,hydroxyl
110774,Modify the molecule CCc1nn(C)cc1C(=O)N[C@@H](CC)c1ccccc1O by removing a amide.,CCc1nn(C)cc1C(=O)N[C@@H](CC)c1ccccc1O,amide
239722,Modify the molecule COc1ccc(C[C@@H](C)[NH3+])cc1OCc1cccc(C)n1 by removing a benzene_ring.,COc1ccc(C[C@@H](C)[NH3+])cc1OCc1cccc(C)n1,benzene_ring
175409,Modify the molecule CCN(Cc1ccc(I)cc1)C(F)(F)F by removing a halo.,CCN(Cc1ccc(I)cc1)C(F)(F)F,halo
178729,Remove a benzene_ring from the molecule Cc1cc(C)c(C(=O)CSc2nnc(C3CC3)n2-c2ccccc2)cc1C.,Cc1cc(C)c(C(=O)CSc2nnc(C3CC3)n2-c2ccccc2)cc1C,benzene_ring
222404,Modify the molecule CNC(=O)/C=C/c1ccc(OC(F)F)cc1OC(F)F by removing a benzene_ring.,CNC(=O)/C=C/c1ccc(OC(F)F)cc1OC(F)F,benzene_ring
139831,Modify the molecule Cc1cc(N)cc(S(=O)(=O)Nc2cc(C)ccc2F)c1 by removing a benzene_ring.,Cc1cc(N)cc(S(=O)(=O)Nc2cc(C)ccc2F)c1,benzene_ring
51524,Remove a benzene_ring from the molecule CCc1ccc(C(=O)[O-])cc1S(=O)(=O)C(CC)CC.,CCc1ccc(C(=O)[O-])cc1S(=O)(=O)C(CC)CC,benzene_ring
84990,Please remove a benzene_ring from the molecule CS(=O)(=O)[N-]c1cccc(NC(=O)C2(c3cc(-c4ccccc4)on3)CC2)c1.,CS(=O)(=O)[N-]c1cccc(NC(=O)C2(c3cc(-c4ccccc4)on3)CC2)c1,benzene_ring
156575,Please remove a benzene_ring from the molecule COc1ccccc1OCC[NH2+]C[C@@]1(C)CC(C)=NO1.,COc1ccccc1OCC[NH2+]C[C@@]1(C)CC(C)=NO1,benzene_ring
163264,Please remove a hydroxyl from the molecule COc1cc(C)c([C@@H](C)[NH2+][C@@H](CO)c2ccc(Cl)cc2)cc1OC.,COc1cc(C)c([C@@H](C)[NH2+][C@@H](CO)c2ccc(Cl)cc2)cc1OC,hydroxyl
11003,Remove a benzene_ring from the molecule COc1ccc(CN2CC[NH+](Cn3nc(C4CC4)n(C)c3=S)CC2)cc1.,COc1ccc(CN2CC[NH+](Cn3nc(C4CC4)n(C)c3=S)CC2)cc1,benzene_ring
212434,Modify the molecule c1cnc(Oc2ccc(CN3CCCC[C@@H]3c3[nH]cc[nH+]3)cc2)cn1 by removing a benzene_ring.,c1cnc(Oc2ccc(CN3CCCC[C@@H]3c3[nH]cc[nH+]3)cc2)cn1,benzene_ring
54182,Remove a amide from the molecule CC(C)Cn1c(C[C@H]2CCN(C(=O)C(C)(C)C)C2)nc2cccnc21.,CC(C)Cn1c(C[C@H]2CCN(C(=O)C(C)(C)C)C2)nc2cccnc21,amide
2030,Remove a amide from the molecule O=C(COc1ccccn1)NCc1ccc(F)cc1.,O=C(COc1ccccn1)NCc1ccc(F)cc1,amide
128241,Please remove a amide from the molecule CC1(C)CCN(C(=O)[C@@H]([NH3+])CC(=O)[O-])C1.,CC1(C)CCN(C(=O)[C@@H]([NH3+])CC(=O)[O-])C1,amide
36265,Remove a benzene_ring from the molecule O=S(=O)(/C=C/c1ccc(Cl)cc1)NCc1ccc2ccccc2c1.,O=S(=O)(/C=C/c1ccc(Cl)cc1)NCc1ccc2ccccc2c1,benzene_ring
83042,Modify the molecule CC(C)(C)NC(=O)c1cccc(S(=O)(=O)[C@@H]2CCS(=O)(=O)C2)c1 by removing a benzene_ring.,CC(C)(C)NC(=O)c1cccc(S(=O)(=O)[C@@H]2CCS(=O)(=O)C2)c1,benzene_ring
3221,Modify the molecule Cc1cc2oc3c(c(=O)c2cc1Cl)[C@H](c1cccnc1)N(CCCN1CCOCC1)C3=O by removing a amide.,Cc1cc2oc3c(c(=O)c2cc1Cl)[C@H](c1cccnc1)N(CCCN1CCOCC1)C3=O,amide
104518,Please remove a hydroxyl from the molecule CC[NH+](Cc1ccc(Oc2ncccn2)cc1)[C@H]1CS(=O)(=O)C[C@@H]1O.,CC[NH+](Cc1ccc(Oc2ncccn2)cc1)[C@H]1CS(=O)(=O)C[C@@H]1O,hydroxyl
196107,Remove a benzene_ring from the molecule COc1cccc(CNC(=O)[C@@H]2CCCN(c3ccc(-c4cccs4)nn3)C2)c1.,COc1cccc(CNC(=O)[C@@H]2CCCN(c3ccc(-c4cccs4)nn3)C2)c1,benzene_ring
66118,Remove a nitro from the molecule Cn1ccc(Nc2ccncc2[N+](=O)[O-])n1.,Cn1ccc(Nc2ccncc2[N+](=O)[O-])n1,nitro
183109,Please remove a benzene_ring from the molecule CC[C@@H]([NH2+]Cc1cccc(-c2n[nH]c(C)n2)c1)c1ccc2c(c1)OCCO2.,CC[C@@H]([NH2+]Cc1cccc(-c2n[nH]c(C)n2)c1)c1ccc2c(c1)OCCO2,benzene_ring
191341,Remove a amide from the molecule CCO[C@@H](C)c1noc(CN2CCN(C(=O)CC(F)(F)F)CC2)n1.,CCO[C@@H](C)c1noc(CN2CCN(C(=O)CC(F)(F)F)CC2)n1,amide
102177,Remove a amide from the molecule Cc1cccc2nc(C(=O)N3CCC[C@@H](C(=O)[O-])C3)cn12.,Cc1cccc2nc(C(=O)N3CCC[C@@H](C(=O)[O-])C3)cn12,amide
170692,Modify the molecule C[NH2+]Cc1ccccc1O[C@@H](C)C(=O)NC(N)=O by removing a amide.,C[NH2+]Cc1ccccc1O[C@@H](C)C(=O)NC(N)=O,amide
63052,Remove a amine from the molecule Clc1cc2c(cc1NCc1nc3c(s1)CCC3)OCO2.,Clc1cc2c(cc1NCc1nc3c(s1)CCC3)OCO2,amine
133690,Modify the molecule C[C@@H]1CCN(C(=O)N[C@@H]2CCC[C@@H]2c2ccc(F)cc2)C[C@H]1O by removing a halo.,C[C@@H]1CCN(C(=O)N[C@@H]2CCC[C@@H]2c2ccc(F)cc2)C[C@H]1O,halo
244338,Remove a halo from the molecule C[C@H](OCC(F)(F)F)C(=O)N1CCC(c2ccc(F)cc2)CC1.,C[C@H](OCC(F)(F)F)C(=O)N1CCC(c2ccc(F)cc2)CC1,halo
206848,Remove a benzene_ring from the molecule COc1ccc(NC(=O)[C@H](C)Sc2cccc(F)c2)cc1OC.,COc1ccc(NC(=O)[C@H](C)Sc2cccc(F)c2)cc1OC,benzene_ring
194065,Modify the molecule C[NH2+][C@@H]1[C@H](C[NH+](C)C[C@@H](C)O)CCC1(C)C by removing a hydroxyl.,C[NH2+][C@@H]1[C@H](C[NH+](C)C[C@@H](C)O)CCC1(C)C,hydroxyl
234627,Please remove a amide from the molecule COc1ccccc1N1CC[C@@H]([NH2+][C@@H](C)C[C@H]2CCCO2)C1=O.,COc1ccccc1N1CC[C@@H]([NH2+][C@@H](C)C[C@H]2CCCO2)C1=O,amide
237778,Please remove a amide from the molecule CC[C@@H](NC(=O)C1C[C@H](C)O[C@H](C)C1)c1ccc(Br)cc1.,CC[C@@H](NC(=O)C1C[C@H](C)O[C@H](C)C1)c1ccc(Br)cc1,amide
177711,Remove a benzene_ring from the molecule C[C@H](NCc1ccnc(O[C@H]2CCOC2)c1)c1ccc(C(F)(F)F)cc1.,C[C@H](NCc1ccnc(O[C@H]2CCOC2)c1)c1ccc(C(F)(F)F)cc1,benzene_ring
210127,Please remove a benzene_ring from the molecule CCc1cccc(C(=O)N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c1O.,CCc1cccc(C(=O)N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c1O,benzene_ring
97706,Modify the molecule COC(=O)c1cc2n(n1)CCN(C(=O)c1cc(-c3ccccc3O)n[nH]1)C2 by removing a amide.,COC(=O)c1cc2n(n1)CCN(C(=O)c1cc(-c3ccccc3O)n[nH]1)C2,amide
66335,Please remove a amide from the molecule CC(C)N(C(=O)CSc1cccc[n+]1[O-])c1ccccc1.,CC(C)N(C(=O)CSc1cccc[n+]1[O-])c1ccccc1,amide
138534,Remove a halo from the molecule CCCCNC(=O)N[C@H]1CCCN(c2ccc(OC(F)F)cc2)C1=O.,CCCCNC(=O)N[C@H]1CCCN(c2ccc(OC(F)F)cc2)C1=O,halo
52333,Modify the molecule COC[C@@H](C)NC(=O)[C@@H](C)N1C(=O)c2cc(Cl)c(Cl)cc2C1=O by removing a amide.,COC[C@@H](C)NC(=O)[C@@H](C)N1C(=O)c2cc(Cl)c(Cl)cc2C1=O,amide
78141,Please remove a halo from the molecule O=C(CC1C[C@@H]2CC[C@H](C1)[NH2+]2)NCCc1ccc(Cl)cc1.,O=C(CC1C[C@@H]2CC[C@H](C1)[NH2+]2)NCCc1ccc(Cl)cc1,halo
195881,Modify the molecule COc1ccc(CC(=O)NC[C@H](c2cccs2)[NH+]2CCCCCC2)cc1 by removing a amide.,COc1ccc(CC(=O)NC[C@H](c2cccs2)[NH+]2CCCCCC2)cc1,amide
141485,Modify the molecule Cc1cccc(OC(=O)CCCN2C(=O)NC3(CCCC3)C2=O)c1 by removing a benzene_ring.,Cc1cccc(OC(=O)CCCN2C(=O)NC3(CCCC3)C2=O)c1,benzene_ring
125694,Modify the molecule CSc1ccc(NC(=O)[C@@H](C)n2nc(-c3cc(C)oc3C)cc(N)c2=O)cc1 by removing a amine.,CSc1ccc(NC(=O)[C@@H](C)n2nc(-c3cc(C)oc3C)cc(N)c2=O)cc1,amine
166022,Please remove a benzene_ring from the molecule Cc1ccc(Br)cc1S(=O)(=O)N1CCC[C@H](N2CCCC2=O)C1.,Cc1ccc(Br)cc1S(=O)(=O)N1CCC[C@H](N2CCCC2=O)C1,benzene_ring
225188,Please remove a amide from the molecule CN(C(=O)c1ccccc1NC(=O)/C=C/c1ccc(Cl)cc1)C1CCCCC1.,CN(C(=O)c1ccccc1NC(=O)/C=C/c1ccc(Cl)cc1)C1CCCCC1,amide
201943,Remove a hydroxyl from the molecule C[C@H](C/C(N)=N/O)N1CC[NH+]2CCC[C@@H]2C1.,C[C@H](C/C(N)=N/O)N1CC[NH+]2CCC[C@@H]2C1,hydroxyl
202906,Please remove a benzene_ring from the molecule CC(=O)Nc1cccc([C@H](C)NC(=O)CCc2ncc(-c3ccc(C)c(C)c3)o2)c1.,CC(=O)Nc1cccc([C@H](C)NC(=O)CCc2ncc(-c3ccc(C)c(C)c3)o2)c1,benzene_ring
204012,Remove a halo from the molecule C[C@H](NC(=O)Cc1cccc(F)c1F)C1(N2CCOCC2)CCCC1.,C[C@H](NC(=O)Cc1cccc(F)c1F)C1(N2CCOCC2)CCCC1,halo
75060,Please remove a amide from the molecule C[C@@H](Cc1ccco1)NC(=O)c1ccc2nsnc2c1.,C[C@@H](Cc1ccco1)NC(=O)c1ccc2nsnc2c1,amide
23755,Remove a amide from the molecule CCc1ccc(-c2nc(CC(=O)Nc3nc(C)c(C)s3)cs2)cc1.,CCc1ccc(-c2nc(CC(=O)Nc3nc(C)c(C)s3)cs2)cc1,amide
249373,Please remove a halo from the molecule Cc1nnc(SCCC(=O)Nc2cccc(F)c2)s1.,Cc1nnc(SCCC(=O)Nc2cccc(F)c2)s1,halo
5892,Modify the molecule O=C(OCC(=O)N1CCCC1)c1cn(-c2ccccc2)nc1-c1ccc(F)cc1 by removing a halo.,O=C(OCC(=O)N1CCCC1)c1cn(-c2ccccc2)nc1-c1ccc(F)cc1,halo
220667,Please remove a amine from the molecule C[C@@](O)(CO)CNc1ncc(Cl)cc1F.,C[C@@](O)(CO)CNc1ncc(Cl)cc1F,amine
188221,Modify the molecule Cc1ccc(O[C@@H](C)C(=O)NCC2(N3CCOCC3)CCCCC2)cc1 by removing a amide.,Cc1ccc(O[C@@H](C)C(=O)NCC2(N3CCOCC3)CCCCC2)cc1,amide
51993,Modify the molecule O=C(c1ccn(COc2ccc(Br)cc2)n1)N1CCCCCC1 by removing a benzene_ring.,O=C(c1ccn(COc2ccc(Br)cc2)n1)N1CCCCCC1,benzene_ring
31084,Remove a nitro from the molecule Cc1ccoc1C(=O)OCc1ccc([N+](=O)[O-])cc1.,Cc1ccoc1C(=O)OCc1ccc([N+](=O)[O-])cc1,nitro
229826,Modify the molecule CC(C)CNC(=O)Nc1ncn(Cc2ccc(C#N)cc2)n1 by removing a nitrile.,CC(C)CNC(=O)Nc1ncn(Cc2ccc(C#N)cc2)n1,nitrile
8807,Please remove a benzene_ring from the molecule CCO[C@@H](C)c1nc(CNc2cccc(-n3nnnc3C)c2)cs1.,CCO[C@@H](C)c1nc(CNc2cccc(-n3nnnc3C)c2)cs1,benzene_ring
86230,Remove a halo from the molecule N#Cc1nc(/C=C/c2ccccc2Cl)oc1N1CCN(C(=O)c2cccc(Cl)c2)CC1.,N#Cc1nc(/C=C/c2ccccc2Cl)oc1N1CCN(C(=O)c2cccc(Cl)c2)CC1,halo
37491,Please remove a amide from the molecule Cc1ccc(C(=O)N2CCCC2)c(C2CCN(C(=O)c3ccoc3)CC2)n1.,Cc1ccc(C(=O)N2CCCC2)c(C2CCN(C(=O)c3ccoc3)CC2)n1,amide
110288,Please remove a benzene_ring from the molecule Cc1nc(N(C)CC[C@H](O)c2ccccc2)c2c(C)nn(C)c2n1.,Cc1nc(N(C)CC[C@H](O)c2ccccc2)c2c(C)nn(C)c2n1,benzene_ring
115081,Please remove a amine from the molecule O=[N+]([O-])c1cnc(NCCCn2cc[nH+]c2)c(Br)c1.,O=[N+]([O-])c1cnc(NCCCn2cc[nH+]c2)c(Br)c1,amine
222482,Remove a amine from the molecule CCOC(=O)c1nc2cnc(NC)nc2n(C)c1=O.,CCOC(=O)c1nc2cnc(NC)nc2n(C)c1=O,amine
228539,Modify the molecule COc1ccc([C@@H]2C(C#N)=C(N)O[C@H]3N=NC(C)=C23)c2ccccc12 by removing a nitrile.,COc1ccc([C@@H]2C(C#N)=C(N)O[C@H]3N=NC(C)=C23)c2ccccc12,nitrile
60066,Remove a hydroxyl from the molecule Cc1cc([C@@H]2NC(=O)NC2=N)cc(C)c1O.,Cc1cc([C@@H]2NC(=O)NC2=N)cc(C)c1O,hydroxyl
84509,Modify the molecule C=CCOc1ccccc1CN1CCNC(=O)[C@@H]1c1ccccc1 by removing a amide.,C=CCOc1ccccc1CN1CCNC(=O)[C@@H]1c1ccccc1,amide
62495,Remove a nitro from the molecule CCN(c1ncnc(NC[C@H]2CCCO2)c1[N+](=O)[O-])c1cccc2ccccc12.,CCN(c1ncnc(NC[C@H]2CCCO2)c1[N+](=O)[O-])c1cccc2ccccc12,nitro
110934,Please remove a amide from the molecule COc1ccc(Cl)cc1NC(=O)C(=O)N[C@H](C)C[NH+]1C[C@H](C)C[C@@H](C)C1.,COc1ccc(Cl)cc1NC(=O)C(=O)N[C@H](C)C[NH+]1C[C@H](C)C[C@@H](C)C1,amide
79413,Please remove a amide from the molecule CNC(=O)[C@@H](C)n1c2ccccc2c2cn[nH]c(=O)c21.,CNC(=O)[C@@H](C)n1c2ccccc2c2cn[nH]c(=O)c21,amide
127284,Remove a amide from the molecule CCCCCC[C@]1(C)NC(=O)N(Cc2csc(C)n2)C1=O.,CCCCCC[C@]1(C)NC(=O)N(Cc2csc(C)n2)C1=O,amide
132630,Remove a benzene_ring from the molecule C[NH+]1[C@H]2CC[C@@H]1CN(C(=O)NCCCS(=O)(=O)c1ccccc1)CC2.,C[NH+]1[C@H]2CC[C@@H]1CN(C(=O)NCCCS(=O)(=O)c1ccccc1)CC2,benzene_ring
170586,Remove a halo from the molecule CCOC(=O)[C@H](C)N(C)Cc1c[nH]nc1-c1c(F)cccc1F.,CCOC(=O)[C@H](C)N(C)Cc1c[nH]nc1-c1c(F)cccc1F,halo
167710,Remove a amine from the molecule COc1ccccc1NS(=O)(=O)c1ccc(Cc2cc(C)n[nH]c2=O)cc1.,COc1ccccc1NS(=O)(=O)c1ccc(Cc2cc(C)n[nH]c2=O)cc1,amine
241335,Modify the molecule COc1cccc(C(=O)Nc2ccn(-c3ccc(C(C)C)cc3)n2)c1 by removing a amide.,COc1cccc(C(=O)Nc2ccn(-c3ccc(C(C)C)cc3)n2)c1,amide
167678,Modify the molecule C/C(CCc1ccccc1)=N\NC(=O)c1ccc(CN2CCOCC2)cc1 by removing a amide.,C/C(CCc1ccccc1)=N\NC(=O)c1ccc(CN2CCOCC2)cc1,amide
137711,Modify the molecule COC(=O)[C@](C)(NCc1ccon1)C1CC1 by removing a amine.,COC(=O)[C@](C)(NCc1ccon1)C1CC1,amine
117862,Remove a amide from the molecule C=CCCC[C@H](C)[NH+]1CCN(C(=O)Cc2c(C)noc2C)CC1.,C=CCCC[C@H](C)[NH+]1CCN(C(=O)Cc2c(C)noc2C)CC1,amide
144220,Remove a amide from the molecule Cc1ccc(OCn2ccc(C(=O)N[C@@H](C)c3cn(C)nc3C)n2)c(C)c1.,Cc1ccc(OCn2ccc(C(=O)N[C@@H](C)c3cn(C)nc3C)n2)c(C)c1,amide
212025,Modify the molecule CC(C)(C)OC(=O)N1CCC(N)(C(N)=O)CC1 by removing a amide.,CC(C)(C)OC(=O)N1CCC(N)(C(N)=O)CC1,amide
99222,Please remove a amide from the molecule Cc1cc(=O)n(CC(=O)N2CCC(c3[nH+]ccn3C)CC2)c2ccccc12.,Cc1cc(=O)n(CC(=O)N2CCC(c3[nH+]ccn3C)CC2)c2ccccc12,amide
75699,Please remove a halo from the molecule O=C(COc1ccc(Oc2ccccc2)cc1)Nc1cc(N2CCCC2=O)ccc1Cl.,O=C(COc1ccc(Oc2ccccc2)cc1)Nc1cc(N2CCCC2=O)ccc1Cl,halo
201619,Modify the molecule Cc1ccsc1CNC(=O)CSc1ncn[nH]1 by removing a amide.,Cc1ccsc1CNC(=O)CSc1ncn[nH]1,amide
39204,Remove a hydroxyl from the molecule Oc1ccccc1/C=N/N1C(=S)[NH+]=N[C@@H]1c1ccc(Cl)cc1Cl.,Oc1ccccc1/C=N/N1C(=S)[NH+]=N[C@@H]1c1ccc(Cl)cc1Cl,hydroxyl
32736,Remove a amide from the molecule CCC(=O)NC(=S)N1CCN(C(c2ccccc2)c2ccccc2)CC1.,CCC(=O)NC(=S)N1CCN(C(c2ccccc2)c2ccccc2)CC1,amide
113946,Remove a amide from the molecule O=C(c1ccncc1Cl)N1CCCC[C@@H]1[C@@H]1CCC[NH2+]1.,O=C(c1ccncc1Cl)N1CCCC[C@@H]1[C@@H]1CCC[NH2+]1,amide
115492,Remove a amine from the molecule COc1ccc2nc(/N=C(\N)NC(=S)Nc3ccc(Cl)cc3)nc(C)c2c1.,COc1ccc2nc(/N=C(\N)NC(=S)Nc3ccc(Cl)cc3)nc(C)c2c1,amine
212176,Please remove a hydroxyl from the molecule O=C(C[C@H]1CCCCO1)N1CCCc2cccc(O)c21.,O=C(C[C@H]1CCCCO1)N1CCCc2cccc(O)c21,hydroxyl
222258,Remove a amide from the molecule CCc1cc(C(F)(F)F)c2c(C3CCN(C(=O)c4cn(C)nc4C)CC3)noc2n1.,CCc1cc(C(F)(F)F)c2c(C3CCN(C(=O)c4cn(C)nc4C)CC3)noc2n1,amide
156633,Modify the molecule CCc1noc(C)c1C(=O)Nc1ccc(Cl)cc1C(F)(F)F by removing a halo.,CCc1noc(C)c1C(=O)Nc1ccc(Cl)cc1C(F)(F)F,halo
179635,Please remove a halo from the molecule O=C(CNc1ccc(-c2nnnn2C2CC2)cc1)N1N=C(c2ccc(Cl)cc2)C[C@H]1c1ccco1.,O=C(CNc1ccc(-c2nnnn2C2CC2)cc1)N1N=C(c2ccc(Cl)cc2)C[C@H]1c1ccco1,halo
144432,Modify the molecule C[C@@H](NC(=O)N[C@@H](c1ccccc1)C(C)(C)C)c1nncn1C by removing a benzene_ring.,C[C@@H](NC(=O)N[C@@H](c1ccccc1)C(C)(C)C)c1nncn1C,benzene_ring
17453,Please remove a halo from the molecule O=C1NCCN1[C@H]1CCC[NH+](C[C@@H]2CC(c3ccc(Cl)cc3)=NO2)C1.,O=C1NCCN1[C@H]1CCC[NH+](C[C@@H]2CC(c3ccc(Cl)cc3)=NO2)C1,halo
141538,Remove a amide from the molecule CN(CCC1CC1)C(=O)c1ccc(C(=O)OC(C)(C)C)cc1.,CN(CCC1CC1)C(=O)c1ccc(C(=O)OC(C)(C)C)cc1,amide
14411,Please remove a benzene_ring from the molecule CC(=O)c1ccc(OC[C@@H](O)CN2CCN(c3ccccc3)CC2)cc1.,CC(=O)c1ccc(OC[C@@H](O)CN2CCN(c3ccccc3)CC2)cc1,benzene_ring
223244,Remove a amide from the molecule Cn1cc[nH+]c1[C@@H]1[C@@H](C(=O)[O-])CC(=O)N1CCc1ccccc1F.,Cn1cc[nH+]c1[C@@H]1[C@@H](C(=O)[O-])CC(=O)N1CCc1ccccc1F,amide
8456,Modify the molecule O=C(N[C@H]1CC=CCC1)N[C@@H]1CCCN(c2ccccc2)C1=O by removing a amide.,O=C(N[C@H]1CC=CCC1)N[C@@H]1CCCN(c2ccccc2)C1=O,amide
245734,Please remove a amide from the molecule COC(=O)C[C@@H]1Oc2ccccc2N(Cc2snnc2C(C)C)C1=O.,COC(=O)C[C@@H]1Oc2ccccc2N(Cc2snnc2C(C)C)C1=O,amide
234051,Please remove a nitrile from the molecule N#Cc1cccc(NC(=O)c2ccc(C[C@H]3CC(=O)NC3=O)cc2)c1.,N#Cc1cccc(NC(=O)c2ccc(C[C@H]3CC(=O)NC3=O)cc2)c1,nitrile
144065,Please remove a halo from the molecule CC(=O)N1CCC([NH+]2CC[C@H](c3nc4cc(F)ccc4o3)C2)CC1.,CC(=O)N1CCC([NH+]2CC[C@H](c3nc4cc(F)ccc4o3)C2)CC1,halo
54900,Modify the molecule COc1ccc(Cl)cc1/N=C(/[S-])Nc1ccccc1C by removing a halo.,COc1ccc(Cl)cc1/N=C(/[S-])Nc1ccccc1C,halo
13636,Please remove a benzene_ring from the molecule CNC(=O)c1cccc(NCc2cn(-c3ccccc3)nc2C(C)C)c1C.,CNC(=O)c1cccc(NCc2cn(-c3ccccc3)nc2C(C)C)c1C,benzene_ring
27378,Modify the molecule C[C@H](C(=O)c1ccc(F)cc1F)n1cnc2c1c(=O)n(C)c(=O)n2C by removing a halo.,C[C@H](C(=O)c1ccc(F)cc1F)n1cnc2c1c(=O)n(C)c(=O)n2C,halo
142883,Modify the molecule CCNC(=O)c1c(NC(=O)c2cc(-c3ccccc3O)[nH]n2)sc2c1CCCC2 by removing a hydroxyl.,CCNC(=O)c1c(NC(=O)c2cc(-c3ccccc3O)[nH]n2)sc2c1CCCC2,hydroxyl
162186,Remove a amide from the molecule Cc1ccc(-n2nc(C(=O)N3CCCC3)c(=O)n(Cc3ccccc3)c2=O)cc1C.,Cc1ccc(-n2nc(C(=O)N3CCCC3)c(=O)n(Cc3ccccc3)c2=O)cc1C,amide
232000,Modify the molecule Cc1cc(-c2c(-c3ccccc3)ncn2CCCO)cc(C)c1O by removing a benzene_ring.,Cc1cc(-c2c(-c3ccccc3)ncn2CCCO)cc(C)c1O,benzene_ring
91206,Modify the molecule CC(C)[NH2+]C[C@@H](O)CN(C)C[C@@H]1CCC[NH+]1C by removing a hydroxyl.,CC(C)[NH2+]C[C@@H](O)CN(C)C[C@@H]1CCC[NH+]1C,hydroxyl
145611,Remove a benzene_ring from the molecule CCn1nc(C)c(CN2CC[NH+](Cc3ccccc3)C[C@H]2C)c1C.,CCn1nc(C)c(CN2CC[NH+](Cc3ccccc3)C[C@H]2C)c1C,benzene_ring
133004,Remove a halo from the molecule COC(=O)C1=C(C)Nc2[nH]c(=S)[nH]c(=O)c2[C@H]1c1ccccc1Cl.,COC(=O)C1=C(C)Nc2[nH]c(=S)[nH]c(=O)c2[C@H]1c1ccccc1Cl,halo
162515,Remove a amide from the molecule Cc1cc(NC(=O)CSc2ccc(S(=O)(=O)N3CCCC3)cn2)no1.,Cc1cc(NC(=O)CSc2ccc(S(=O)(=O)N3CCCC3)cn2)no1,amide
222426,Please remove a amide from the molecule Cc1ncsc1C(=O)NNC(=O)NC[C@H]1CCC(C)(C)c2ccccc21.,Cc1ncsc1C(=O)NNC(=O)NC[C@H]1CCC(C)(C)c2ccccc21,amide
189406,Remove a halo from the molecule C[C@H](Oc1ccc(Br)cc1)C(=O)N[C@H](C)c1ccc(-n2ccnc2)cc1.,C[C@H](Oc1ccc(Br)cc1)C(=O)N[C@H](C)c1ccc(-n2ccnc2)cc1,halo
72047,Remove a halo from the molecule COc1ccc(-c2nn3c(SCC(=O)c4ccc(Cl)cc4)nnc3nc2[O-])cc1.,COc1ccc(-c2nn3c(SCC(=O)c4ccc(Cl)cc4)nnc3nc2[O-])cc1,halo
30686,Remove a halo from the molecule Cc1ccc(NC(=O)[C@@H]2C[C@H]3CC[C@@H]2O3)cc1Br.,Cc1ccc(NC(=O)[C@@H]2C[C@H]3CC[C@@H]2O3)cc1Br,halo
234892,Remove a thiol from the molecule OC[C@@H]1CCCC[NH+]1CCS.,OC[C@@H]1CCCC[NH+]1CCS,thiol
227896,Please remove a amide from the molecule NC(=O)[C@@H](NC[C@@H]1CCCO1)c1ccc(Br)cc1F.,NC(=O)[C@@H](NC[C@@H]1CCCO1)c1ccc(Br)cc1F,amide
43812,Remove a amide from the molecule Cc1cccc(CN2CCN(C(=O)c3cc(C#N)cn3C)CC2)c1.,Cc1cccc(CN2CCN(C(=O)c3cc(C#N)cn3C)CC2)c1,amide
73039,Please remove a amide from the molecule N#Cc1csc(C(=O)N2C[C@H]3CC=CC[C@@H]3C2)c1.,N#Cc1csc(C(=O)N2C[C@H]3CC=CC[C@@H]3C2)c1,amide
108540,Modify the molecule CNS(=O)(=O)c1ccc(N(C)Cc2ccc(Br)cc2)c([N+](=O)[O-])c1 by removing a halo.,CNS(=O)(=O)c1ccc(N(C)Cc2ccc(Br)cc2)c([N+](=O)[O-])c1,halo
142063,Modify the molecule COc1ccc(NC(=O)c2cccc(OC(C)=O)c2)cc1OC by removing a amide.,COc1ccc(NC(=O)c2cccc(OC(C)=O)c2)cc1OC,amide
202890,Please remove a amide from the molecule C[C@@H](NC(=O)c1ccccc1NC(=O)OCc1ccccc1)c1ccccc1.,C[C@@H](NC(=O)c1ccccc1NC(=O)OCc1ccccc1)c1ccccc1,amide
225419,Remove a amine from the molecule Nc1ccc(COCc2ccccc2)c2ncccc12.,Nc1ccc(COCc2ccccc2)c2ncccc12,amine
213105,Please remove a benzene_ring from the molecule CC[C@H]1CCC[C@@H](NC(=O)C(=O)Nc2ccccc2OCC2CC2)C1.,CC[C@H]1CCC[C@@H](NC(=O)C(=O)Nc2ccccc2OCC2CC2)C1,benzene_ring
35125,Modify the molecule CC(C)(O)CC[C@H]1C[C@@H](C(C)(C)C)CCC1=O by removing a hydroxyl.,CC(C)(O)CC[C@H]1C[C@@H](C(C)(C)C)CCC1=O,hydroxyl
12975,Please remove a halo from the molecule C[C@H](C(=O)NCCc1ccco1)n1c(=O)c(C(F)(F)F)nc2ccccc21.,C[C@H](C(=O)NCCc1ccco1)n1c(=O)c(C(F)(F)F)nc2ccccc21,halo
98161,Modify the molecule O=C(Nc1ccc(Nc2ccccc2)cc1)c1ccc(O)nc1 by removing a amine.,O=C(Nc1ccc(Nc2ccccc2)cc1)c1ccc(O)nc1,amine
59252,Modify the molecule Cn1cccc1[C@@H](CNC(=O)NCCc1ccccc1)[NH+]1CCCCCC1 by removing a benzene_ring.,Cn1cccc1[C@@H](CNC(=O)NCCc1ccccc1)[NH+]1CCCCCC1,benzene_ring
19596,Remove a benzene_ring from the molecule COc1cccc(S(=O)(=O)/N=C([O-])/C(C#N)=C\c2ccco2)c1.,COc1cccc(S(=O)(=O)/N=C([O-])/C(C#N)=C\c2ccco2)c1,benzene_ring
201743,Please remove a amide from the molecule COCC(=O)N[C@H](C)c1nc2ccccc2[nH]1.,COCC(=O)N[C@H](C)c1nc2ccccc2[nH]1,amide
13859,Modify the molecule CCc1cccc(C)c1NC(=O)NCC1CC1 by removing a benzene_ring.,CCc1cccc(C)c1NC(=O)NCC1CC1,benzene_ring
17967,Modify the molecule Cc1ccc(-c2nnc(C[NH+]3CCC[C@H]3C[NH+]3CCC[C@@H]3CO)o2)cc1 by removing a hydroxyl.,Cc1ccc(-c2nnc(C[NH+]3CCC[C@H]3C[NH+]3CCC[C@@H]3CO)o2)cc1,hydroxyl
10540,Please remove a hydroxyl from the molecule C=C(C)C[C@@H](O)[C@]1([NH+](C)C)CCC[C@@H](C)C1.,C=C(C)C[C@@H](O)[C@]1([NH+](C)C)CCC[C@@H](C)C1,hydroxyl
43340,Remove a benzene_ring from the molecule CO[C@@H](C(=O)NCc1n[nH]c(=S)n1C(C)C)c1ccccc1.,CO[C@@H](C(=O)NCc1n[nH]c(=S)n1C(C)C)c1ccccc1,benzene_ring
208901,Remove a halo from the molecule Cc1cc(C[NH2+]Cc2ccc3c(c2)CCC3)cc(C)c1F.,Cc1cc(C[NH2+]Cc2ccc3c(c2)CCC3)cc(C)c1F,halo
171465,Modify the molecule Cc1ccc(NC(=O)Cn2c(=O)ncc3cc(S(=O)(=O)N4CCCC[C@@H]4C)ccc32)c(C)c1 by removing a amide.,Cc1ccc(NC(=O)Cn2c(=O)ncc3cc(S(=O)(=O)N4CCCC[C@@H]4C)ccc32)c(C)c1,amide
226551,Remove a amide from the molecule COc1cccc(NC(=O)CSc2nccn(-c3ccc(C)c(C)c3)c2=O)c1.,COc1cccc(NC(=O)CSc2nccn(-c3ccc(C)c(C)c3)c2=O)c1,amide
60204,Please remove a hydroxyl from the molecule Cc1cc([C@@H](C)NC(=O)CCCCO)c(C)s1.,Cc1cc([C@@H](C)NC(=O)CCCCO)c(C)s1,hydroxyl
88769,Remove a amide from the molecule O=C([O-])c1ccc(N2C(=O)/C(=C/C3=c4ccccc4=[NH+]C3)SC2=S)cc1O.,O=C([O-])c1ccc(N2C(=O)/C(=C/C3=c4ccccc4=[NH+]C3)SC2=S)cc1O,amide
38832,Modify the molecule CCN(Cc1ccccn1)C(=O)[C@H]1C[C@H]1c1ccc(Cl)cc1 by removing a halo.,CCN(Cc1ccccn1)C(=O)[C@H]1C[C@H]1c1ccc(Cl)cc1,halo
39688,Please remove a benzene_ring from the molecule CCCNC(=O)[C@@H](C)S(=O)(=O)Cc1cc(-c2ccccc2)on1.,CCCNC(=O)[C@@H](C)S(=O)(=O)Cc1cc(-c2ccccc2)on1,benzene_ring
27595,Remove a benzene_ring from the molecule CN1CCc2nc[nH]c2C12CC[NH+](Cc1cccc(OC3CCCC3)c1)CC2.,CN1CCc2nc[nH]c2C12CC[NH+](Cc1cccc(OC3CCCC3)c1)CC2,benzene_ring
92665,Remove a benzene_ring from the molecule Cc1cc([N-]S(=O)(=O)/C=C/c2ccccc2)no1.,Cc1cc([N-]S(=O)(=O)/C=C/c2ccccc2)no1,benzene_ring
95196,Modify the molecule C[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCC[C@@H]1C(=O)N(C)C by removing a halo.,C[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCC[C@@H]1C(=O)N(C)C,halo
195974,Modify the molecule COc1ccccc1NC(=O)c1c([O-])c2sccc2n(Cc2ccccc2)c1=O by removing a benzene_ring.,COc1ccccc1NC(=O)c1c([O-])c2sccc2n(Cc2ccccc2)c1=O,benzene_ring
174889,Modify the molecule CSC[C@@](C)(O)CNC(=O)c1cc(-c2ccccc2)on1 by removing a amide.,CSC[C@@](C)(O)CNC(=O)c1cc(-c2ccccc2)on1,amide
199628,Please remove a hydroxyl from the molecule COc1ccc(NC(=O)N[C@H](CO)CC(C)C)cc1OC.,COc1ccc(NC(=O)N[C@H](CO)CC(C)C)cc1OC,hydroxyl
200159,Modify the molecule N/C(=N/c1ccccc1)S[C@@H]1CC(=O)N(c2ccc(F)cc2)C1=O by removing a benzene_ring.,N/C(=N/c1ccccc1)S[C@@H]1CC(=O)N(c2ccc(F)cc2)C1=O,benzene_ring
215921,Please remove a amine from the molecule O=C(c1ccc(=O)n(Cc2ccccc2)n1)[n+]1ccccc1NC1CCCCC1.,O=C(c1ccc(=O)n(Cc2ccccc2)n1)[n+]1ccccc1NC1CCCCC1,amine
211636,Please remove a amide from the molecule COc1ccc(CCCNC(=O)[C@@H]2CN(C)CCO2)cc1OC.,COc1ccc(CCCNC(=O)[C@@H]2CN(C)CCO2)cc1OC,amide
94134,Modify the molecule Cc1csc(C[S@@](=O)c2ccccc2F)n1 by removing a benzene_ring.,Cc1csc(C[S@@](=O)c2ccccc2F)n1,benzene_ring
6972,Remove a benzene_ring from the molecule C[C@@H]1C[NH+](CCOc2ccc(CC[NH3+])cc2)C[C@@H]1C.,C[C@@H]1C[NH+](CCOc2ccc(CC[NH3+])cc2)C[C@@H]1C,benzene_ring
24068,Modify the molecule CC[NH2+][C@@H](c1ccccc1OCC)[C@@H](C)c1ccccn1 by removing a benzene_ring.,CC[NH2+][C@@H](c1ccccc1OCC)[C@@H](C)c1ccccn1,benzene_ring
183163,Remove a amide from the molecule CCNC(=O)[C@@H]1CCCN(C(=O)N[C@@H](CCCO)c2ccccc2)C1.,CCNC(=O)[C@@H]1CCCN(C(=O)N[C@@H](CCCO)c2ccccc2)C1,amide
182068,Modify the molecule CCOc1ccc(NC(=S)N2C[C@@H](C)O[C@H](C)C2)cc1 by removing a benzene_ring.,CCOc1ccc(NC(=S)N2C[C@@H](C)O[C@H](C)C2)cc1,benzene_ring
150489,Remove a benzene_ring from the molecule Cc1ccccc1NC(=O)c1c(C)nc(Nc2nc3ccccc3o2)nc1C.,Cc1ccccc1NC(=O)c1c(C)nc(Nc2nc3ccccc3o2)nc1C,benzene_ring
74660,Modify the molecule C[C@H]1CCC[C@H]([C@H](O)C2(C#N)CCC2)C1 by removing a hydroxyl.,C[C@H]1CCC[C@H]([C@H](O)C2(C#N)CCC2)C1,hydroxyl
108174,Remove a amide from the molecule CC(=O)Nc1cccc(-n2c(C)nn(C[C@H](O)c3ccccc3)c2=S)c1.,CC(=O)Nc1cccc(-n2c(C)nn(C[C@H](O)c3ccccc3)c2=S)c1,amide
228484,Please remove a benzene_ring from the molecule CCc1ccc(NC(=O)[C@H](C)Oc2ccc(OC)cc2)cc1.,CCc1ccc(NC(=O)[C@H](C)Oc2ccc(OC)cc2)cc1,benzene_ring
214265,Please remove a benzene_ring from the molecule CCOc1cc(C=O)cc(Br)c1OC(=O)c1ccccc1Cl.,CCOc1cc(C=O)cc(Br)c1OC(=O)c1ccccc1Cl,benzene_ring
233105,Modify the molecule COc1cccc(N2CC[NH+]([C@H](C)c3nc(C(C)(C)C)no3)CC2)c1 by removing a benzene_ring.,COc1cccc(N2CC[NH+]([C@H](C)c3nc(C(C)(C)C)no3)CC2)c1,benzene_ring
200020,Remove a benzene_ring from the molecule CCc1cccc(C)c1NC(=O)N[C@@H](C)C[NH+]1CCCCC1.,CCc1cccc(C)c1NC(=O)N[C@@H](C)C[NH+]1CCCCC1,benzene_ring
244994,Remove a benzene_ring from the molecule Cc1ccc(C)c(CC(=O)c2ccc(F)c(F)c2F)c1.,Cc1ccc(C)c(CC(=O)c2ccc(F)c(F)c2F)c1,benzene_ring
108658,Modify the molecule Fc1ccc(-n2ncc3c(N4CCCc5ccccc54)ncnc32)cc1 by removing a halo.,Fc1ccc(-n2ncc3c(N4CCCc5ccccc54)ncnc32)cc1,halo
98069,Please remove a nitrile from the molecule N#CCC[C@H](C#N)CN1CCc2c(cccc2N2CCOC2=O)C1.,N#CCC[C@H](C#N)CN1CCc2c(cccc2N2CCOC2=O)C1,nitrile
162615,Modify the molecule COC(=O)[C@@H]1CCC[C@@H]1NC(=O)c1cccc(Nc2cnn(C)c2)c1 by removing a amide.,COC(=O)[C@@H]1CCC[C@@H]1NC(=O)c1cccc(Nc2cnn(C)c2)c1,amide
171750,Modify the molecule CC[C@@H]([NH2+][C@@H](C)c1nc2cc(Cl)ccc2n1C)C(=O)N1CCOCC1 by removing a halo.,CC[C@@H]([NH2+][C@@H](C)c1nc2cc(Cl)ccc2n1C)C(=O)N1CCOCC1,halo
63279,Modify the molecule CC1=N[C@H]2C(C(=O)N3CCC(N4c5[nH+]cccc5N[C@@H]4C4CCC4)CC3)=CC=CC2=C1C by removing a amide.,CC1=N[C@H]2C(C(=O)N3CCC(N4c5[nH+]cccc5N[C@@H]4C4CCC4)CC3)=CC=CC2=C1C,amide
224522,Please remove a amide from the molecule CCOC(=O)c1ccc(CNC(=O)c2cc(-c3csc(C)n3)c[nH]2)o1.,CCOC(=O)c1ccc(CNC(=O)c2cc(-c3csc(C)n3)c[nH]2)o1,amide
229805,Modify the molecule COc1ccccc1CNC(=O)[C@H](C)Sc1nnc(-c2c[nH]c3ccccc23)o1 by removing a benzene_ring.,COc1ccccc1CNC(=O)[C@H](C)Sc1nnc(-c2c[nH]c3ccccc23)o1,benzene_ring
201625,Modify the molecule CCc1nnc(NC(=O)c2ccccc2NC(=O)[C@H]2CC(=O)N(c3ccc(Cl)cc3)C2)s1 by removing a benzene_ring.,CCc1nnc(NC(=O)c2ccccc2NC(=O)[C@H]2CC(=O)N(c3ccc(Cl)cc3)C2)s1,benzene_ring
175244,Modify the molecule CC(C)OCCCNC(=O)C1CCN(C(=O)[C@@H]2CCO[C@H]2C)CC1 by removing a amide.,CC(C)OCCCNC(=O)C1CCN(C(=O)[C@@H]2CCO[C@H]2C)CC1,amide
99778,Please remove a amide from the molecule C[C@H]1CCC[C@H](CC[NH+]2CCNC(=O)C2)C1.,C[C@H]1CCC[C@H](CC[NH+]2CCNC(=O)C2)C1,amide
1518,Remove a amide from the molecule CCc1nc(C)sc1CNC(=O)CCc1nc(-c2ccccc2C)no1.,CCc1nc(C)sc1CNC(=O)CCc1nc(-c2ccccc2C)no1,amide
214555,Modify the molecule O=C(OCCN1C(=O)c2ccccc2C1=O)c1ccccc1C(=O)c1ccccc1 by removing a amide.,O=C(OCCN1C(=O)c2ccccc2C1=O)c1ccccc1C(=O)c1ccccc1,amide
110896,Please remove a benzene_ring from the molecule COc1cccc(C[C@@H](C)NC(=O)c2ccccc2C(C)=O)c1.,COc1cccc(C[C@@H](C)NC(=O)c2ccccc2C(C)=O)c1,benzene_ring
99489,Remove a amide from the molecule Cc1ccc(N2C[C@H](C(=O)N3CCN(c4nccn4-c4cccc(Cl)c4)CC3)CC2=O)cc1C.,Cc1ccc(N2C[C@H](C(=O)N3CCN(c4nccn4-c4cccc(Cl)c4)CC3)CC2=O)cc1C,amide
91042,Modify the molecule C[C@H](CNC(=O)c1cccc2[nH]ccc12)[NH+]1CCCC1 by removing a amide.,C[C@H](CNC(=O)c1cccc2[nH]ccc12)[NH+]1CCCC1,amide
172490,Modify the molecule C[C@@H](C(=O)Nc1ccc(Cl)cc1)S(=O)(=O)c1ccc(O)cc1 by removing a halo.,C[C@@H](C(=O)Nc1ccc(Cl)cc1)S(=O)(=O)c1ccc(O)cc1,halo
52632,Remove a amide from the molecule CCN(CC)c1ccc(C(=O)Nc2ccc3oc(COC)nc3c2)cn1.,CCN(CC)c1ccc(C(=O)Nc2ccc3oc(COC)nc3c2)cn1,amide
220183,Modify the molecule Cc1ccc(NC(=O)NC[C@@H](C)Oc2ccccc2F)s1 by removing a benzene_ring.,Cc1ccc(NC(=O)NC[C@@H](C)Oc2ccccc2F)s1,benzene_ring
401,Modify the molecule COCCNC(=O)/C(C#N)=C/c1cccc(O)c1 by removing a amide.,COCCNC(=O)/C(C#N)=C/c1cccc(O)c1,amide
248001,Please remove a amide from the molecule Cc1cccc(C(=O)NCCn2nc(-c3cccnc3)ccc2=O)c1.,Cc1cccc(C(=O)NCCn2nc(-c3cccnc3)ccc2=O)c1,amide
82097,Please remove a benzene_ring from the molecule COc1ccc(-c2nnc(SCC(C)=O)n2C2CCCCC2)cc1.,COc1ccc(-c2nnc(SCC(C)=O)n2C2CCCCC2)cc1,benzene_ring
238090,Modify the molecule C[C@@H](Cc1ccc(Cl)cc1Cl)C(=O)N(C)C1CCOCC1 by removing a benzene_ring.,C[C@@H](Cc1ccc(Cl)cc1Cl)C(=O)N(C)C1CCOCC1,benzene_ring
209211,Please remove a benzene_ring from the molecule CN(CC1CC[NH2+]CC1)C[C@H](C#N)c1ccccc1.,CN(CC1CC[NH2+]CC1)C[C@H](C#N)c1ccccc1,benzene_ring
102826,Modify the molecule CCC[NH2+][C@@H](COC)C1(c2ccccc2)CCCC1 by removing a benzene_ring.,CCC[NH2+][C@@H](COC)C1(c2ccccc2)CCCC1,benzene_ring
113995,Please remove a benzene_ring from the molecule CCc1ccccc1NCc1c(C(C)C)nn(C)c1N1CCOCC1.,CCc1ccccc1NCc1c(C(C)C)nn(C)c1N1CCOCC1,benzene_ring
134045,Please remove a benzene_ring from the molecule CCC[C@@H](NC(=O)c1ccc(Cl)c(OC)c1)C(=O)OC.,CCC[C@@H](NC(=O)c1ccc(Cl)c(OC)c1)C(=O)OC,benzene_ring
225288,Please remove a amide from the molecule CCOc1ccc(CC(=O)Nc2ccc(S(N)(=O)=O)c(C)c2)cc1.,CCOc1ccc(CC(=O)Nc2ccc(S(N)(=O)=O)c(C)c2)cc1,amide
131149,Modify the molecule C[C@H]1C[C@H]1c1ccc(/C=C/C(=O)Nc2ccccc2C(=O)NC2CC2)o1 by removing a amide.,C[C@H]1C[C@H]1c1ccc(/C=C/C(=O)Nc2ccccc2C(=O)NC2CC2)o1,amide
171158,Modify the molecule CCOc1ccc(C(=O)CC(F)(F)F)c(Br)c1 by removing a halo.,CCOc1ccc(C(=O)CC(F)(F)F)c(Br)c1,halo
8365,Please remove a amide from the molecule CC[NH+]1CCC(CC(=O)N[C@H](C(=O)[O-])c2ccc(F)cc2F)CC1.,CC[NH+]1CCC(CC(=O)N[C@H](C(=O)[O-])c2ccc(F)cc2F)CC1,amide
195491,Modify the molecule CC[C@](C)([NH2+]CC(=O)Nc1c(C)n[nH]c1C)C(=O)[O-] by removing a amide.,CC[C@](C)([NH2+]CC(=O)Nc1c(C)n[nH]c1C)C(=O)[O-],amide
108754,Please remove a benzene_ring from the molecule Cc1ccc(C(=O)CCC(=O)NCc2ccc(N3CCOCC3)[nH+]c2)cc1.,Cc1ccc(C(=O)CCC(=O)NCc2ccc(N3CCOCC3)[nH+]c2)cc1,benzene_ring
136578,Modify the molecule COc1ccc(CNC(=O)[C@H]2CCCN(C(=O)NC3CC3)C2)cc1 by removing a amide.,COc1ccc(CNC(=O)[C@H]2CCCN(C(=O)NC3CC3)C2)cc1,amide
215702,Modify the molecule CC(C)[C@@H](NC(=O)c1ccccc1F)C(=O)N[C@@H]1CCCC[C@@H]1C by removing a halo.,CC(C)[C@@H](NC(=O)c1ccccc1F)C(=O)N[C@@H]1CCCC[C@@H]1C,halo
113391,Remove a benzene_ring from the molecule CCCOCC(=O)Nc1cc(C(N)=O)ccc1C.,CCCOCC(=O)Nc1cc(C(N)=O)ccc1C,benzene_ring
82724,Please remove a amine from the molecule O=C([O-])c1cccc(-c2cc(NCc3ccccn3)nc3[nH]ccc23)c1.,O=C([O-])c1cccc(-c2cc(NCc3ccccn3)nc3[nH]ccc23)c1,amine
114282,Remove a halo from the molecule O=C1N[C@H](c2ccc(F)cc2)C(C(=O)c2cccs2)=C1O.,O=C1N[C@H](c2ccc(F)cc2)C(C(=O)c2cccs2)=C1O,halo
220560,Modify the molecule CC[C@@H](C)[C@@]1(O)CSCC(C)(C)C1 by removing a hydroxyl.,CC[C@@H](C)[C@@]1(O)CSCC(C)(C)C1,hydroxyl
101778,Modify the molecule COCCn1c(C(=O)NCCN2CCN(C(C)=O)CC2)cc2ccccc21 by removing a amide.,COCCn1c(C(=O)NCCN2CCN(C(C)=O)CC2)cc2ccccc21,amide
9738,Modify the molecule O=C(CCc1cccc(F)c1)Nc1n[nH]c2ccc([N+](=O)[O-])cc12 by removing a benzene_ring.,O=C(CCc1cccc(F)c1)Nc1n[nH]c2ccc([N+](=O)[O-])cc12,benzene_ring
115675,Remove a benzene_ring from the molecule Cc1ccc(NC(=O)c2ccccc2NC(=O)c2cc(C)n(C)n2)c(C(=O)c2ccccc2)c1.,Cc1ccc(NC(=O)c2ccccc2NC(=O)c2cc(C)n(C)n2)c(C(=O)c2ccccc2)c1,benzene_ring
239779,Modify the molecule O=C([O-])c1cncc(Nc2ccc(Cl)cc2C(F)(F)F)n1 by removing a halo.,O=C([O-])c1cncc(Nc2ccc(Cl)cc2C(F)(F)F)n1,halo
198029,Modify the molecule Cc1noc(CCCNC(=O)N[C@@H](c2ccccc2)c2ccco2)n1 by removing a benzene_ring.,Cc1noc(CCCNC(=O)N[C@@H](c2ccccc2)c2ccco2)n1,benzene_ring
165793,Remove a halo from the molecule COC(=O)c1ccc2c(c1C)N[C@H](c1cc(Br)c(OC)c(OC)c1)[C@H]1CC=C[C@H]21.,COC(=O)c1ccc2c(c1C)N[C@H](c1cc(Br)c(OC)c(OC)c1)[C@H]1CC=C[C@H]21,halo
77724,Remove a amide from the molecule O=C(Cc1cccc2ccccc12)N[C@H](c1ccccc1)c1ccncc1.,O=C(Cc1cccc2ccccc12)N[C@H](c1ccccc1)c1ccncc1,amide
49912,Remove a benzene_ring from the molecule O=C(NN=C1CCCc2ccccc21)C(O)(c1ccccc1)c1ccccc1.,O=C(NN=C1CCCc2ccccc21)C(O)(c1ccccc1)c1ccccc1,benzene_ring
204098,Modify the molecule Cc1c(NC(=O)c2cccc3cc[nH]c23)cccc1C(=O)N1CCCC1 by removing a amide.,Cc1c(NC(=O)c2cccc3cc[nH]c23)cccc1C(=O)N1CCCC1,amide
94261,Please remove a hydroxyl from the molecule CC1CCC(N2C[C@@H](C(=O)N[C@H](CO)c3ccco3)CC2=O)CC1.,CC1CCC(N2C[C@@H](C(=O)N[C@H](CO)c3ccco3)CC2=O)CC1,hydroxyl
18702,Remove a benzene_ring from the molecule CCOc1ccc(N2C(=O)C[C@H](SCC(=O)Nc3cccc(Cl)c3C)C2=O)cc1.,CCOc1ccc(N2C(=O)C[C@H](SCC(=O)Nc3cccc(Cl)c3C)C2=O)cc1,benzene_ring