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The glycosyltransferase (GT) domain of FsoA may convert isomotiol, 2-alpha-hydroxy-isomotiol, and the acetylated derivative of 2-alpha-hydroxy-isomotiol into their corresponding glycosides 3-O-(beta-D-glucopyranosyl)-isomotiol, 3-O-(beta-D-glucopyranosyl)-2-alpha-hydroxy-isomotiol, and 3-O-(beta-D-glucopyranosyl)-2-alpha-acetoxy-isomotiol, which then undergo oxidative cleavage under the action of fsoE to form s 2-deacetoxy-fuscoatroside, 2-deacetyl-fuscoatroside, and fuscoatroside, respectively. Although hydroxylation followed by acetylation of 3-O-(beta-D-glucopyranosyl)-isomotiol and 2-deacetoxy-fuscoatroside by fsoD and fsoF could not be ruled out, this process is likely to occur with difficulty due to bulky steric hindrance caused by the presence of a glycan at C3 in these compounds. Interestingly, fsoE can also utilize the aglycones isomotiol and 2-alpha-hydroxy-isomotiol as substrates to generate 19-beta-hydroxy-isomotiol and 2-alpha,19-beta-dihydroxy-isomotiol, respectively. 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The glycosyltransferase (GT) domain of FsoA may convert isomotiol, 2-alpha-hydroxy-isomotiol, and the acetylated derivative of 2-alpha-hydroxy-isomotiol into their corresponding glycosides 3-O-(beta-D-glucopyranosyl)-isomotiol, 3-O-(beta-D-glucopyranosyl)-2-alpha-hydroxy-isomotiol, and 3-O-(beta-D-glucopyranosyl)-2-alpha-acetoxy-isomotiol, which then undergo oxidative cleavage under the action of fsoE to form s 2-deacetoxy-fuscoatroside, 2-deacetyl-fuscoatroside, and fuscoatroside, respectively. Although hydroxylation followed by acetylation of 3-O-(beta-D-glucopyranosyl)-isomotiol and 2-deacetoxy-fuscoatroside by fsoD and fsoF could not be ruled out, this process is likely to occur with difficulty due to bulky steric hindrance caused by the presence of a glycan at C3 in these compounds. Interestingly, fsoE can also utilize the aglycones isomotiol and 2-alpha-hydroxy-isomotiol as substrates to generate 19-beta-hydroxy-isomotiol and 2-alpha,19-beta-dihydroxy-isomotiol, respectively. 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PFLSRADRTDAACLSKMTSSAEWLEKNFGLFSGYATVEFLEALNVNFSSLGSLSLLNPTQVAEITLSSGALNNTDQIVVVFDRLEKGDAFLNMKEFLTELNAAPEIPVISPAVSDVMMNRTFAIIEGYFRKFETHDWVVWFTVNLVPILPSFTTEMLVKVTASVNCTDYRVIVKGLGINFQRMTFTRRQEITNVLVEHLKTTAAKFSMPGCRQKTESAAEWLDTNLGRFSSSASYSDLKSLNISMLAALGSLAPDQKAELLLDPSTDALDNVTVVQEVLTSILTSPDEKQLEMFFETFVKVSKVESITYIENVAVRDTMLNLTMTALAPKLPLFETSDYELWFQTNLVVLLASFSPTVLEVIPANITCESYQAILEGMKIALADLPSGVGVELNSSVDTLQHSPPKACTTPPPTTPPTVPPTMPSTTPSPVPPTAPPTVSPTAVCEETLIDEERLCAGVDSEQLQTSGSVAAQLCNFSIPEYACSSVASSLSSDDLVTLLTCKASTVMSNSTEMWKLFFQKVTGVLENALSVYSSQNLSNGHAASNILDAIGQLTISNFSASQLTNASFITAWFQERLRPFLPSVSVEFLSCLSTKNFSCDSYQAAVLGLSRQSSLMAMETKQDVFNAFIKPFLSRADRTDAACLSKMTSSAEWLEKNFGLFSGYATVEFLEALNVNFSSLGSLSLLNPTQVAEITLSSGALNNTDQIVVVFDRLEKGDAFLNMKEFLTELNAAPEIPVISPAVSDVMMNRTFAIIEGYFRKFETHDWVVWFTVNLVPILPSFTTEMLVKVTASVNCTDYRVIVKGLGINFQRMTFTRRQEITNVLVEHLKTTAAKFSMPGCRQKTESAAEWLDTNLGRFSSSASYSDLKSLNISMLAALGSLAPDQKAELLLDPSTDALDNVTVVQEVLTSILTSPDEKQLEMFFETFVKVSKVESITYIENVAVRDTMLNLTMTALAPKLPLFETSDYELWFQTNLVVLLASFSPTVLEVIPANITCESYQAILEGMKIALADLPSGVGVELNSSVDTLQHSPPKACTTPPPTTPPTVPPTMPSTTPSPVPPTAPPTVSPTAVCEETLIDEERLCAGVDSEQLQTSGSVAAQLCNFSIPEYACSSVASSLSSDDLVTLLTCKASTVMSNSTEMWKLFFQKVTGVLENALSVYSSQNLSNGHAASNILDAIGQLTISNFSASQLTNASFITAWFQERLRPFLPSVSVEFLSCLSTKNFSCDSYQAAVLGLSRQSSLMAMETKQDVFNAFIKPFLSRADRTDAACLSKMTSSAEWLEKNFGLFSGYATVEFLEALNVNFSSLGSLSLLNPTQVAEITLSSGALNNTDQIVVVFDRLEKGDAFLNMKEFLTELNAAPEIPVISPAVSDVMMNRTFAIIEGYFRKFETHDWVVWFTVNLVPILPSFTTEMLVKVTASVNCTDYRVIVKGLGINFQRMTFTRRQEITNVLVEHLKTTAAKFSMPGCRQKTESAAEWLDTNLGRFSSSASYSDLKSLNISMLAALGSLAPDQKAELLLDPSTDALDNVTVVQEVLTSILTSPDEKQLEMFFETFVKVSKVESITYIENVAVRDTMLNLTMTALAPKLPLFETSDYELWFQTNLVVLLASFSPTVLEVIPANITCESYQAILEGMKIALADLPSGVGVELNSSVDTLQHSPPKACTTPPPTTPPTVPPTMPSTTPSPVPPTAPPTVSPTAVCEETLIDEERLCAGVDSEQLQTSGSVAAQLCNFSIPEYACSSVASSLSSDDLVTLLTCKASTVMSNSTEMWKLFFQKVTGVLENALSVYSSQNLSNGHAASNILDAIGQLTISNFSASQLTNASFITAWFQERLRPFLPSVSVEFLSCLSTKNFSCDSYQAAVLGLSRQSSLMAMETKQDVFNAFIKPFLSRADRTDAACLSKMTSSAEWLEKNFGLFSGYATVEFLEALNVNFSSLGSLSLLNPTQVAEITLSSGALNNTDQIVVVFDRLEKGDAFLNMKEFLTELNAAPEIPVISPAVSDVMMNRTFAIIEGYFRKFETHDWVVWFTVNLVPILPSFTTEMLVKVTASVNCTDYRVIVKGLGINFQRMTFTRRQEITNVLVEHLKTTAAKFSMPGCRQKTESAAEWLDTNLGRFSSSASYSDLKSLNISMLAALGSLAPDQKAELLLDPSTDALDNVTVVQEVLTSILTSPDEKQLEMFFETFVKVSKVESITYIENVAVRDTMLNLTMTALAPKLPLFETSDYELWFQTNLVVLLASFSPTVLEVIPANITCESYQAILEGMKIALADLPSGVGVELNSSVDTLQHSPPKACTTPPPTTPPTVPPTMPSTTPSPVPPTAPPTVSPTAVCEETLIDEERLCAGVDSEQLQTSGSVAAQLCNFSIPEYACSSVASSLSSDDLVTLLTCKASTVMSNSTEMWKLFFQKVTGVLENALSVYSSQNLSNGHAASNILDAIGQLTISNFSASQLTNASFITAWFQERLRPFLPSVSVEFLSCLSTKNFSCDSYQAAVLGLSRQSSLMAMETKQDVFNAFIKPFLSRADRTDAACLSKMTSSAEWLEKNFGLFSGYATVEFLEALNVNFSSLGSLSLLNPTQVAEITLSSGALNNTDQIVVVFDRLEKGDAFLNMKEFLTELNAAPEIPVISPAVSDVMMNRTFAIIEGYFRKFETHDWVVWFTVNLVPILPSFTTEMLVKVTASVNCTDYRVIVKGLGINFQRMTFTRRQEITNVLVEHLKTTAAKFSMPGCRQKTESAAEWLDTNLGRFSSSASYSDLKSLNISMLAALGSLAPDQKAELLLDPSTDALDNVTVVQEVLTSILTSPDEKQLEMFFETFVKVSKVESITYIENVAVRDTMLNLTMTALAPKLPLFETSDYELWFQTNLVVLLASFSPTVLEVIPANITCESYQAILEGMKIALADLPSGVGVELNSSVDTLQHSPPKACTTPPPTTPPTVPPTMPSTTPSPVPPTAPPTVSPTAVCEETLIDEERLCAGVDSEQLQTSGSVAAQLCNFSIPEYACSSVASSLSSDDLVTLLTCKASTVMSNSTEMWKLFFQKVTGVLENALSVYSSQNLSNGHAASNILDAIGQLTISNFSASQLTNASFITAWFQERLRPFLPSVSVEFLSCLSTKNFSCDSYQAAVLGLSRQSSLMAMETKQDVFNAFIKPFLSRADRTDAACLSKMTSSAEWLEKNFGLFSGYATVEFLEALNVNFSSLGSLSLLNPTQVAEITLSSGALNNTDQIVVVFDRLEKGDAFLNMKEFLTELNAAPEIPVISPAVSDVMMNRTFAIIEGYFRKFETHDWVVWFTVNLVPILPSFTTEMLVKVTASVNCTDYRVIVKGLGINFQRMTFTRRQEITNVLVEHLKTTAAKFSMPGCRQKTESAAEWLDTNLGRFSSSASYSDLKSLNISMLAALGSLAPDQKAELLLDPSTDALDNVTVVQEVLTSILTSPDEKQLEMFFETFVKVSKVESITYIENVAVRDTMLNLTMTALAPKLPLFETSDYELWFQTNLVVLLASFSPTVLEVIPANITCESYQAILEGMKIALADLPSGVGVELNSSVDTLQHSPPKACTTPPPTTPPTVPPTMPSTTPSPVPPTAPPTVSPTAVCEETLIDEERLCAGVDSEQLQTSGSVAAQLCNFSIPEYACSSVASSLSSDDLVTLLTCKASTVMSNSTEMWKLFFQKVTGVLENALSVYSSQNLSNGHAASNILDAIGQLTISNFSASQLTNASFITAWFQERLRPFLPSVSVEFLSCLSTKNFSCDSYQAAVLGLSRQSSLMAMETKQDVFNAFIKPFLSRADRTDAACLSKMTSSAEWLEKNFGLFSGYATVEFLEALNVNFSSLGSLSLLNPTQVAEITLSSGALNNTDQIVVVFDRLEKGDAFLNMKEFLTELNAAPEIPVISSAVSDVMMNRTFAIIEGYFRKFETHDWVVWFTVNLVPILPSFTTEMLVKVTASVNCTDYRVIVKGLGINFQRMTFTRRQEITNVLVEHLKTTAAKFSMPGCRQKTESAAEWLDTNLGRFSSLASYSDLKSLNISMLAALGSLAPDQKAELLLDPSTDALDNVTVVQEVLTSILTSPDEKQLEMFFETFVKVSKVESITYIENVAVRDTMLNLTMTALAPKLPLFETSDYELWFQTNLVVLLASFSPTVLEVIPANITCESYQAILEGMKIALADLPSGVGVELNSSVDTLQHSPPKACTTPPPTTPPTVPPTMPSTTPSPVPPTAPPTVSPTAVCEETLIDEERLCAGVDSEQLQTSGSVAAQLCNFSIPEYACSSVASSLSSDDLVTLLTCKASTVMSNSTEMWKLFFQKVTGVLENALSVYSSQNLSNGHAVSNILDAIGQLTISNFSASQLTNASFITAWFQERLRPFLPSVSVEFLSCLSTKNFSCDSYQAAVLGLSRQSSLMAMETKQDVFNAFIKPFLSRADRTDAACLSKMTSSAEWLEKNFGLFSGYATVEFLEALNVNFSSLGSLSLLNPTQVAEITLSSGALNNTDQIVVVFDRLEKGDAFLNMKEFLTELNAAPEIPVISPAVSDVMMNRTFAIIEGYFRKFETHDWVVWFTVNLVPILPSFTTEMLVKVTASVNCTDYRVIVKGLGINFQRMTFTRRQEITNVLVEHLKTTAAKFSMPGCRQKTESAAEWLDTNLGRFSSLASYSDLKSLNISMLAALGSLAPDQKAELLLDPSTDALDNVTVVQEVLTSILTSPDEKQLEMFFETFVKVSKVESITYIENVAVRDTMLNLTMTALAPKLPLFETSDYELWFQTNLVVLLASFSPTVLEVIPANITCESYQAILEGMKIALADLPSGVGVELNSSVDTLQHSPPKACTTPPPTTPPTVPPTMPSTTPSPVPPTAPPTVSPTAVCEETLIDEERLCAGVDSEQLQTSGSVAAQLCNFSIPEYACSSVASSLSSDDLVTLLTCKASTVMSNSTEMWKLFFQKVTGVLENALSVYSSQNLSNGHAASNILDAIGQLTISNFSASQLTNASFITAWFQERLRPFLPSVSVEFLSCLSTKNFSCDSYQAAVLGLSRQSSLMAMETKQDVFNAFIKPFLSRADRTDAACLSKMTSSAEWLEKNFGLFSGYATVEFLEALNVNFSSLGSLSLLNPTQVAEITLSSGALNNTDQIVVVFDRLEKGDAFLNMKEFLTELNAAPEIPVISPAVSDVMMNRTFAIIEGYFRKFETHDWVVWFTVNLVPILPSFTTEMLVKVTASVNCTDYRVIVKGLGINFQRMTFTRRQEITNVLVEHLKTTAAKFSMPGCRQKTESAAEWLDTNLGRFSSLASYSDLKSLNISMLAALGSLAPDQKAELLLDPSTDALDNVTVVQEVLTSILTSPDEKQLEMFFETFVKVSKVESITYIENVAVRDTMLNLTMTALAPKLPLFETSDYELWFQTNLVVLLASFSPTVLEVIPANITCESYQAILEGMKIALADLPSGVGVELNSSVDKLQHSPPKACMTAPPTTPPTVPPTMPYTLTPTAPNTGPPIAQPTATPTMPSTTPSTVPPTAPPTTLTVLPTLTYTMLPTSPNTVPPIVPPTAPPTTPPTAAPTLPYTMPNTAPNTAPPIASPTATPTMLSTTPITVPPTAPPTTVPPTVPYTMPPTALNTATAIAPPTASPTMSSTTLSTVAPPTTPPTAPPTLPYTMPPTALNTATVIAPPTASPTMPSTTLSTVAPTAPPTTPPTVPSTLPYTMPPTSSNTVPPISPPTATPTMPSTVPPTAPPTTPPTAPPTLPYTMPPTSPNTAPPIASPTATPTMPSTTPTTIPPTAPPTTPPTVPPTLPYTMPPTALNTATAIATPTASPTMPSTTLSTVAPTAPPTTPPTVPSTLPYTMPPTFPNTVPPISPSTATPTMPSTTPFTVPPTTAPTAPPTLPYTMPPTALNTVTVIAPLTASPTMPSTAPSTVAPPTVLSTLPYTMPPTSPNTVPPISPPTATPTMPSTTPSTVSQTAPATTPHTVPPTLPYTVPPTSPNTVPSISPTTAPPTTSSTEPPMLPYTMPPTALNTATAIAPPTASPTMPSITPSTVPPTAPPTTAPTVPPTLPYTVPPTSPNTVPPIAPTTAPPTTSSTVPPTLPYTMPPTALNTATVIAPPTSSPTMASTTLSMVAPTAPPTTPPTAPPTLPYTMPPTALNTATAIAPPTASPTMPSITPSTVAATAPPTTLPYSMPPTAKNTVPPIAPPTATPTLPSTTPSTVPPTATTTTLSTVPPTLPSTTPSTVPPTAPPTVSPTAVCEETLIDEERLCAGVDSEQLQTSGSVAAQLCNFSIPEYACSSVASSLSSDDLVMLLTCKASTVMSNSTEMWKLFFQKVTGVLENALSVYSSQNLSNGHAVSNILDAIGQLTISNFSASQLTNASFITAWFQERLRPFLPSVSVEFLSCLSTKNFSCDSYQAAVLGLSRQSSLMAMETKQDVFNAFIKPFLSRADRTDAACLSKMTSSAEWLEKNFGLFSGYATVEFLEALNVNFSSLGSLSLLNPTQVAEITLSSGALNNTDQIVVVFDRLEKGDAFLNMKEFLTELNAAPEIPVISPAVSDVMMNRTFAIIEGYFRKFETHDWVVWFTVNLVPILPSFTTEMLVKVTASVNCTDYRVIVKGLSKVYSQMPVQRRKEIAAGLVAHLKQIVYQINQPACKQGITNDSDWLQMNLGQFFNYVPYSDLAAFNISSEAVFGSLTDEQKVERILIPGLLEDETSVRQLFASVVNSQNQLKQFFITFTSMSAQRNVFSVSTTVSSVILNMTLVALEDRFQNFFPQTFADWFQTYLRIFLPGIGPNTLSVIPLTINCDSYTEIVRGCDDVFSKLTSVQTNDVYRFTMDYLTHKPSPGSSCVQGTSNSSDWLMKSFGRFSMWASFSDLISLNKDFDGVEAAALLTPPQLAQLCSAPSRLSGPQDVQTVMSVLDTQQLTLFFNDLSQNISVSGLVYPAQLKQAFLQVVLNRRDLWSSSLSDAEVSLWLTVRLRPLLSSLTASDVSPYFAIVASRGCGVRQTAVTELNTLRTALDGNTQREIYNSILQLLTGSPLRCYTGGSFLLFLRSSFQQFGLPDLSSVLSLIPQASRTQVLSSMSPSELSEFLNVTQAVGSSSGLCELLSAYNQTAVYLQTAPLGSQALARQVLTCVWPGVLQLNGPSEVNEWFDLRLLRYLPLLTLQLISPAELQSASCLSYRKLISVLGKNYNYSETNFSPEDVYSSIKEYLSNDGSPRCYNAADPQLNSTDWFVSYIGVFISYVSLSDLNSFVSSDQIGVFLEDPGNLQLLNSTAGIQSSVVEYYITQLYILDQYFNPMSVPPQFLCDIPAVAFEPLSEADSLRLIQSINMYCNGTQNPQITAALTDNLPSLSSNTIELLGNQSVGLTEGQISAAPPAVIRSSLATLSSVDGWSQGQADAIVQTLIQSNYVIDSDSSLLALGTLVKGLPSDTLSSIQPSTLLSVSQNPTFISNMVAAPQVLQMVYVMQIVSIDVTQVLQNVPDQLASSIPPVLLAPQGSVNLSLINQKQWTQEQALVLFSSVASVSQDTEELSVPVLQGFSCTSVQTVSTQKVKQMVRSCRHRPGRSKVQLQESQLMCMNNYVKDEPLSSFSDLPAEVLLYYSYDNVQPVNCRSYFSAVGQADYSVLSSVLNKPAALFANARSCLGITGNSLSKDQIAVLGNLTCTLDPVYIPNSDPSIIESLKNCVELSDAQISAVQRLLLSGNTSYGNSSTWGQQTLQRLAKIPLYFTNSFWSLFSATVKKNFMTTFMPYLRSINTDKTKLKTLFSNCNSGLSRSRLSRSTACTVGNITAATIADPSFPLGYTVDQFDACLEPGVLKDTLTAVAQKVDDSSFQRVILNKLKQVYPAGLADGVVKDLGSVSRQASVQEISSWNISSLDTLATLMDKSNGNWSTAQSQQVILRYLSVKGNSLGSNELNIIKSSLCSLNISTLQNITPAVLRNAKALDLSSCSSEQQSVLYITANSSFRAQLSNGPAYYHMISPYLGNTHTHTHTSLSLDCVLLG","length":12665,"molWeight":1373521,"crc64":"882C4FD682D0EB0F","md5":"48AE077E24C0A11282F1DF498B4C92D1"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR 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