Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Pentatomomorpha Pentatomoidea Pentatomidae Asopinae Eocanthecona

Pheromone/general odorant binding protein domain


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo

Proprotein convertase subtilisin/kexin type 9

International Human Genome Sequencing Consortium

Lander E.S.
Linton L.M.
Birren B.
Nusbaum C.
Zody M.C.
Baldwin J.
Devon K.
Dewar K.
Doyle M.
FitzHugh W.
Funke R.
Gage D.
Harris K.
Heaford A.
Howland J.
Kann L.
Lehoczky J.
LeVine R.
McEwan P.
McKernan K.
Meldrim J.
Mesirov J.P.
Miranda C.
Morris W.
Naylor J.
Raymond C.
Rosetti M.
Santos R.
Sheridan A.
Sougnez C.
Stange-Thomann N.
Stojanovic N.
Subramanian A.
Wyman D.
Rogers J.
Sulston J.
Ainscough R.
Beck S.
Bentley D.
Burton J.
Clee C.
Carter N.
Coulson A.
Deadman R.
Deloukas P.
Dunham A.
Dunham I.
Durbin R.
French L.
Grafham D.
Gregory S.
Hubbard T.
Humphray S.
Hunt A.
Jones M.
Lloyd C.
McMurray A.
Matthews L.
Mercer S.
Milne S.
Mullikin J.C.
Mungall A.
Plumb R.
Ross M.
Shownkeen R.
Sims S.
Waterston R.H.
Wilson R.K.
Hillier L.W.
McPherson J.D.
Marra M.A.
Mardis E.R.
Fulton L.A.
Chinwalla A.T.
Pepin K.H.
Gish W.R.
Chissoe S.L.
Wendl M.C.
Delehaunty K.D.
Miner T.L.
Delehaunty A.
Kramer J.B.
Cook L.L.
Fulton R.S.
Johnson D.L.
Minx P.J.
Clifton S.W.
Hawkins T.
Branscomb E.
Predki P.
Richardson P.
Wenning S.
Slezak T.
Doggett N.
Cheng J.F.
Olsen A.
Lucas S.
Elkin C.
Uberbacher E.
Frazier M.
Gibbs R.A.
Muzny D.M.
Scherer S.E.
Bouck J.B.
Sodergren E.J.
Worley K.C.
Rives C.M.
Gorrell J.H.
Metzker M.L.
Naylor S.L.
Kucherlapati R.S.
Nelson D.L.
Weinstock G.M.
Sakaki Y.
Fujiyama A.
Hattori M.
Yada T.
Toyoda A.
Itoh T.
Kawagoe C.
Watanabe H.
Totoki Y.
Taylor T.
Weissenbach J.
Heilig R.
Saurin W.
Artiguenave F.
Brottier P.
Bruls T.
Pelletier E.
Robert C.
Wincker P.
Smith D.R.
Doucette-Stamm L.
Rubenfield M.
Weinstock K.
Lee H.M.
Dubois J.
Rosenthal A.
Platzer M.
Nyakatura G.
Taudien S.
Rump A.
Yang H.
Yu J.
Wang J.
Huang G.
Gu J.
Hood L.
Rowen L.
Madan A.
Qin S.
Davis R.W.
Federspiel N.A.
Abola A.P.
Proctor M.J.
Myers R.M.
Schmutz J.
Dickson M.
Grimwood J.
Cox D.R.
Olson M.V.
Kaul R.
Raymond C.
Shimizu N.
Kawasaki K.
Minoshima S.
Evans G.A.
Athanasiou M.
Schultz R.
Roe B.A.
Chen F.
Pan H.
Ramser J.
Lehrach H.
Reinhardt R.
McCombie W.R.
de la Bastide M.
Dedhia N.
Blocker H.
Hornischer K.
Nordsiek G.
Agarwala R.
Aravind L.
Bailey J.A.
Bateman A.
Batzoglou S.
Birney E.
Bork P.
Brown D.G.
Burge C.B.
Cerutti L.
Chen H.C.
Church D.
Clamp M.
Copley R.R.
Doerks T.
Eddy S.R.
Eichler E.E.
Furey T.S.
Galagan J.
Gilbert J.G.
Harmon C.
Hayashizaki Y.
Haussler D.
Hermjakob H.
Hokamp K.
Jang W.
Johnson L.S.
Jones T.A.
Kasif S.
Kaspryzk A.
Kennedy S.
Kent W.J.
Kitts P.
Koonin E.V.
Korf I.
Kulp D.
Lancet D.
Lowe T.M.
McLysaght A.
Mikkelsen T.
Moran J.V.
Mulder N.
Pollara V.J.
Ponting C.P.
Schuler G.
Schultz J.
Slater G.
Smit A.F.
Stupka E.
Szustakowski J.
Thierry-Mieg D.
Thierry-Mieg J.
Wagner L.
Wallis J.
Wheeler R.
Williams A.
Wolf Y.I.
Wolfe K.H.
Yang S.P.
Yeh R.F.
Collins F.
Guyer M.S.
Peterson J.
Felsenfeld A.
Wetterstrand K.A.
Patrinos A.
Morgan M.J.
de Jong P.
Catanese J.J.
Osoegawa K.
Shizuya H.
Choi S.
Chen Y.J.

Initial sequencing and analysis of the human genome.

NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

Finishing the euchromatic sequence of the human genome.

Gregory S.G.
Barlow K.F.
McLay K.E.
Kaul R.
Swarbreck D.
Dunham A.
Scott C.E.
Howe K.L.
Woodfine K.
Spencer C.C.
Jones M.C.
Gillson C.
Searle S.
Zhou Y.
Kokocinski F.
McDonald L.
Evans R.
Phillips K.
Atkinson A.
Cooper R.
Jones C.
Hall R.E.
Andrews T.D.
Lloyd C.
Ainscough R.
Almeida J.P.
Ambrose K.D.
Anderson F.
Andrew R.W.
Ashwell R.I.
Aubin K.
Babbage A.K.
Bagguley C.L.
Bailey J.
Beasley H.
Bethel G.
Bird C.P.
Bray-Allen S.
Brown J.Y.
Brown A.J.
Buckley D.
Burton J.
Bye J.
Carder C.
Chapman J.C.
Clark S.Y.
Clarke G.
Clee C.
Cobley V.
Collier R.E.
Corby N.
Coville G.J.
Davies J.
Deadman R.
Dunn M.
Earthrowl M.
Ellington A.G.
Errington H.
Frankish A.
Frankland J.
French L.
Garner P.
Garnett J.
Gay L.
Ghori M.R.
Gibson R.
Gilby L.M.
Gillett W.
Glithero R.J.
Grafham D.V.
Griffiths C.
Griffiths-Jones S.
Grocock R.
Hammond S.
Harrison E.S.
Hart E.
Haugen E.
Heath P.D.
Holmes S.
Holt K.
Howden P.J.
Hunt A.R.
Hunt S.E.
Hunter G.
Isherwood J.
James R.
Johnson C.
Johnson D.
Joy A.
Kay M.
Kershaw J.K.
Kibukawa M.
Kimberley A.M.
King A.
Knights A.J.
Lad H.
Laird G.
Lawlor S.
Leongamornlert D.A.
Lloyd D.M.
Loveland J.
Lovell J.
Lush M.J.
Lyne R.
Martin S.
Mashreghi-Mohammadi M.
Matthews L.
Matthews N.S.
McLaren S.
Milne S.
Mistry S.
Moore M.J.
Nickerson T.
O'Dell C.N.
Oliver K.
Palmeiri A.
Palmer S.A.
Parker A.
Patel D.
Pearce A.V.
Peck A.I.
Pelan S.
Phelps K.
Phillimore B.J.
Plumb R.
Rajan J.
Raymond C.
Rouse G.
Saenphimmachak C.
Sehra H.K.
Sheridan E.
Shownkeen R.
Sims S.
Skuce C.D.
Smith M.
Steward C.
Subramanian S.
Sycamore N.
Tracey A.
Tromans A.
Van Helmond Z.
Wall M.
Wallis J.M.
White S.
Whitehead S.L.
Wilkinson J.E.
Willey D.L.
Williams H.
Wilming L.
Wray P.W.
Wu Z.
Coulson A.
Vaudin M.
Sulston J.E.
Durbin R.
Hubbard T.
Wooster R.
Dunham I.
Carter N.P.
McVean G.
Ross M.T.
Harrow J.
Olson M.V.
Beck S.
Rogers J.
Bentley D.R.
Banerjee R.
Bryant S.P.
Burford D.C.
Burrill W.D.
Clegg S.M.
Dhami P.
Dovey O.
Faulkner L.M.
Gribble S.M.
Langford C.F.
Pandian R.D.
Porter K.M.
Prigmore E.

The DNA sequence and biological annotation of human chromosome 1.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Peiratinae Ectomocoris

Pacifastin

Reactive bond

F:serine-type endopeptidase inhibitor activity

Belongs to the protease inhibitor I19 family


Zdenek C.N.
Cardoso F.C.
Robinson S.D.
Mercedes R.S.
Raidjoe E.R.
Hernandez-Vargas M.J.
Jin J.
Corzo G.
Vetter I.
King G.F.
Fry B.G.
Walker A.

Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Clitellata Hirudinea Hirudinida Hirudiniformes Hirudinidae Hirudo

SCP domain-containing protein

SCP


Eukaryota Metazoa Porifera Demospongiae Verongimorpha Chondrillida Halisarcidae Halisarca

Disordered

Disordered

Low complexity


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Noctuoidea Noctuidae Hadeninae Mythimna

Identification and sex expression profiles of olfactory-related genes in Mythimna loreyi based on antennal transcriptome analysis.

Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3


Stylosanthes guianensis subsp. guianensis

Eukaryota
Viridiplantae
Streptophyta
Embryophyta
Tracheophyta
Spermatophyta
Magnoliopsida
eudicotyledons
Gunneridae
Pentapetalae
rosids
fabids
Fabales
Fabaceae
Papilionoideae
50 kb inversion clade
dalbergioids sensu lato
Dalbergieae
Pterocarpus clade
Stylosanthes

BHLH

Disordered

Low complexity

Wang W.
Zhang Z.S.
Yang Y.L.
Luo L.L.
Jiang J.L.

SPERMATOGENESIS- AND OOGENESIS-SPECIFIC BASIC HELIX-LOOP-HELIX-CONTAINING PROTEIN 1

HLH, helix-loop-helix DNA-binding domain


Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)

Bacteria Bacillati Actinomycetota Actinomycetes Mycobacteriales Mycobacteriaceae Mycolicibacterium

Probable antitoxin PhoAT

Fleischmann R.D.
Dodson R.J.
Haft D.H.
Merkel J.S.
Nelson W.C.
Fraser C.M.

Deshayes C.
Perrodou E.
Gallien S.
Euphrasie D.
Schaeffer C.
Van-Dorsselaer A.
Poch O.
Lecompte O.
Reyrat J.-M.

Interrupted coding sequences in Mycobacterium smegmatis: authentic mutations or sequencing errors?

Gallien S.
Perrodou E.
Carapito C.
Deshayes C.
Reyrat J.-M.
Van Dorsselaer A.
Poch O.
Schaeffer C.
Lecompte O.

Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol.

The mycobacterial PhoH2 proteins are type II toxin antitoxins coupled to RNA helicase domains.

IDENTIFICATION BY MASS SPECTROMETRY
FUNCTION
SUBUNIT
OPERON STRUCTURE
DISRUPTION PHENOTYPE

Probable antitoxin component of a type II toxin-antitoxin (TA) system. The probable cognate antitoxin is PhoAT; the toxin gene can be expressed in the absence of the antitoxin gene in M.smegmatis strain mc(2)155 (PubMed:25999286)

Interacts with toxin PhoH2 (PubMed:25999286)

Part of the phoAT-phoH2 operon (PubMed:25999286)

Deletion of the phoAT-phoH2 genes has no visible growth phenotype (PubMed:25999286)


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Sternorrhyncha Coccoidea Pseudococcidae Maconellicoccus

S S.B.
Negi N.
Nagarjuna Reddy K.
R G.G.

Takout-proteins of Maconellicoccus hirsutus.

Haemolymph juvenile hormone binding protein


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Scorpiones Iurida Chactoidea Euscorpiidae Scorpiopinae Scorpiopini Euscorpiops

Antimicrobial peptide Eval967

Leucine amide

Zeng Z.
Zhang R.
Hong W.
Cheng Y.
Wang H.
Lang Y.
Ji Z.
Wu Y.
Li W.
Xie Y.
Cao Z.

Histidine-rich modification of a scorpion-derived peptide improves bioavailability and inhibitory activity against HSV-1.

NUCLEOTIDE SEQUENCE [MRNA]
SYNTHESIS OF 23-36
PROBABLE AMIDATION AT LEU-36

Probable antimicrobial peptide. Has no inhibitory activity against herpes simplex virus type 1 (HSV-1)

Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short antimicrobial peptide (group 4) family


Helical

P-type

Disordered

Disordered

Disordered

Low complexity

Polar residues

Zody M.C.
Garber M.
Adams D.J.
Sharpe T.
Harrow J.
Lupski J.R.
Nicholson C.
Searle S.M.
Wilming L.
Young S.K.
Abouelleil A.
Allen N.R.
Bi W.
Bloom T.
Borowsky M.L.
Bugalter B.E.
Butler J.
Chang J.L.
Chen C.K.
Cook A.
Corum B.
Cuomo C.A.
de Jong P.J.
DeCaprio D.
Dewar K.
FitzGerald M.
Gilbert J.
Gibson R.
Gnerre S.
Goldstein S.
Grafham D.V.
Grocock R.
Hafez N.
Hagopian D.S.
Hart E.
Norman C.H.
Humphray S.
Jaffe D.B.
Jones M.
Kamal M.
Khodiyar V.K.
LaButti K.
Laird G.
Lehoczky J.
Liu X.
Lokyitsang T.
Loveland J.
Lui A.
Macdonald P.
Major J.E.
Matthews L.
Mauceli E.
McCarroll S.A.
Mihalev A.H.
Mudge J.
Nguyen C.
Nicol R.
O'Leary S.B.
Osoegawa K.
Schwartz D.C.
Shaw-Smith C.
Stankiewicz P.
Steward C.
Swarbreck D.
Venkataraman V.
Whittaker C.A.
Yang X.
Zimmer A.R.
Bradley A.
Hubbard T.
Birren B.W.
Rogers J.
Lander E.S.
Nusbaum C.

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

Lacks conserved residue(s) required for the propagation of feature annotation


Eukaryota Metazoa Spiralia Lophotrochozoa Platyhelminthes Rhabditophora Seriata Tricladida Continenticola Geoplanoidea Dugesiidae Dugesia

VWFA

VWFA

Identification of a collagen alpha-4 like gene in planarian Dugesia japonica.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Stenopodainae Oncocephalus

Disordered

Low complexity


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Leucinodes

Helical

Helical

Helical

Helical

Helical

Helical

Pathak J.
Thiruvengadam V.
Gracy G.R.
M M.


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Pleocyemata Brachyura Eubrachyura Potamoidea Potamidae Aparapotamon

AB hydrolase-1

Shi B.Y.
Pan D.
Zhang K.Q.
Gu T.Y.
Yeo D.C.J.
Ng P.K.L.
Cumberlidge N.
Sun H.Y.

Diversification of freshwater crabs on the sky islands in the Hengduan Mountains Region, China.


Fibronectin type-III

Fibronectin type-III

Fibronectin type-III

Disordered

Low complexity

Polar residues

FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN


Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Aplacophora Solenogastres Cavibelonia Epimeniidae Epimenia

PAS

PAS

Disordered

Basic residues

Belato F.A.
Mello B.
Coates C.J.
Halanych K.M.
Brown F.D.
Morandini A.C.
Leme J.M.
Trindade R.I.F.
Costa-Paiva E.M.

Divergence time estimates for the hypoxia-inducible factor-1 alpha (HIF1a) reveal an ancient emergence of animals in low-oxygen environments.

F:DNA-binding transcription factor activity, RNA polymerase II-specific

F:RNA polymerase II transcription regulatory region sequence-specific DNA binding

Hypoxia-inducible factor 1-alpha isoform 1


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Amphibia Batrachia Anura Neobatrachia Microhyloidea Microhylidae Dyscophinae Dyscophus

Galectin

Recurrent evolution of adhesive defence systems in amphibians by parallel shifts in gene expression.

P:negative regulation of CD4-positive, alpha-beta T cell proliferation

P:negative regulation of type II interferon production

P:positive regulation of gene expression


Eukaryota Amoebozoa Evosea Eumycetozoa Myxogastria Myxogastromycetidae Physariida Physaraceae Physarum

FYVE-type

Minami Y.
Morita R.
Okano S.
Ishii K.
Furukawa A.
Teramoto C.

Analysis of trehalose synthesis pathway from Physarum polycephalum.

Glycoside hydrolase, family 65, N-terminal domain

Zinc/RING finger domain, C3HC4 (zinc finger)

alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose

Belongs to the glycosyl hydrolase 65 family


Eukaryota
Fungi
Fungi incertae sedis
Microsporidia
Pereziidae
Ameson


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Acari Acariformes Trombidiformes Prostigmata Eleutherengona Heterostigmata Tarsonemoidea Tarsonemidae Polyphagotarsonemus

Helical

Helical

Helical

Helical

Helical

Helical

G-protein coupled receptors family 3 profile

Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).

C:G protein-coupled receptor heterodimeric complex

F:G protein-coupled GABA receptor activity

P:gamma-aminobutyric acid signaling pathway

Gamma-aminobutyric acid type B receptor subunit 2

GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2

Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Scorpiones Buthida Buthoidea Buthidae Tityus

Cryptide Pep-2

Dias N.B.
de Souza B.M.
Cocchi F.K.
Chalkidis H.M.
Dorce V.A.C.
Palma M.S.

Profiling the short, linear, non-disulfide bond-containing peptidome from the venom of the scorpion Tityus obscurus.

PROTEIN SEQUENCE
IDENTIFICATION BY MASS SPECTROMETRY
SUBCELLULAR LOCATION
SYNTHESIS
FUNCTION
BIOASSAY

Presents weak hemolytic activity at physiological concentrations (micromolar range), and weak lactate dehydrogenase (LDH) release from mast cells. Does not induce mast cell degranulation, and antimicrobial effects. In vivo, injection into mice induces very weak or no change in nociceptive sensibility, and very reduced or no edema formation. It also reduces mice locomotion, suggesting an increase in anxiety, but causes no alteration in rearing (standing on hind limbs)


Helical

Helical

Helical

Helical

Ionotropic glutamate receptor C-terminal

Ionotropic glutamate receptor L-glutamate and glycine-binding

Crucial to convey clamshell closure to channel opening

Interaction with the cone snail toxin Con-ikot-ikot

F:transmitter-gated monoatomic ion channel activity

P:cell surface receptor signaling pathway

Glutamate receptor ionotropic, kainate 1

Glutamate receptor ionotropic, kainate 2

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Clitellata Oligochaeta Enchytraeida Enchytraeidae Enchytraeus

PUM-HD

Pumilio

Pumilio

Pumilio

Pumilio

Pumilio

Pumilio

Pumilio

Pumilio

Disordered

Disordered

Disordered

Disordered

Disordered

Disordered

Polar residues

Polar residues

Pro residues

Kostyuchenko R.P.
Nikanorova D.D.
Amosov A.V.

Germ Line/Multipotency Genes Show Differential Expression during Embryonic Development of the Annelid Enchytraeus coronatus.

P:post-transcriptional regulation of gene expression


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Neopterygii Teleostei Neoteleostei Acanthomorphata Eupercaria Sciaenidae Argyrosomus

Hemopexin

Hemopexin


Eukaryota Metazoa Porifera Demospongiae Verongimorpha Chondrillida Halisarcidae Halisarca

NIDO

Immunoglobulin

Immunoglobulin subtype 2

Immunoglobulin

Immunoglobulin subtype 2

Immunoglobulin

Immunoglobulin subtype 2

Immunoglobulin

Immunoglobulin subtype 2

Immunoglobulin

Immunoglobulin subtype 2

Immunoglobulin

Immunoglobulin subtype 2

P:homophilic cell adhesion via plasma membrane adhesion molecules


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo

Zhong J.
Gao Y.M.
Mo C.P.
Zhang Y.
Li L.B.
Wei S.T.
Li T.Y.

Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A

HISTO-BLOOD GROUP ABO SYSTEM TRANSFERASE

Belongs to the glycosyltransferase 6 family


Helical


Eukaryota Metazoa Chordata Tunicata Ascidiacea Phlebobranchia Cionidae Ciona

Helical

Helical

Helical

Helical

Helical

Long T.
Zhang Y.
Donnelly L.
Li H.
Pien Y.C.
Liu N.
Olson E.N.
Li X.

Cryo-EM structures of Myomaker reveal a molecular basis for myoblast fusion.

STRUCTURE BY ELECTRON MICROSCOPY (3.22 ANGSTROMS)

POST-GPI ATTACHMENT TO PROTEINS FACTOR 6


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Peiratinae Ectomocoris

CUB

Disordered

Basic and acidic residues

Lacks conserved residue(s) required for the propagation of feature annotation


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae rosids fabids Rosales Elaeagnaceae Hippophae

MADS-box

Zhao J.
Xu Y.
Zhang Z.
Zhao M.
Li K.
Wang F.
Sun K.

Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.

F:DNA-binding transcription factor activity, RNA polymerase II-specific

F:RNA polymerase II cis-regulatory region sequence-specific DNA binding

P:positive regulation of transcription by RNA polymerase II


Glycosyl transferase family 28 C-terminal

Belongs to the UDP-glycosyltransferase family


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Amphibia Batrachia Anura Neobatrachia Ranoidea Ranidae Nidirana

Zheng P.
Gong Y.
Wang B.
Yu H.
Huang S.
Liao X.
Jiang J.
Ran J.
Xie F.

Love Hug-Functional Validation of Nuptial Pad-Secreted Pheromone in Anurans.


Cryptide Pep-16

PROTEIN SEQUENCE
IDENTIFICATION BY MASS SPECTROMETRY
SUBCELLULAR LOCATION


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Neopterygii Teleostei Ostariophysi Cypriniformes Danionidae Danioninae Danio

Howe K.
Clark M.D.
Torroja C.F.
Torrance J.
Berthelot C.
Muffato M.
Collins J.E.
Humphray S.
McLaren K.
Matthews L.
McLaren S.
Sealy I.
Caccamo M.
Churcher C.
Scott C.
Barrett J.C.
Koch R.
Rauch G.J.
White S.
Chow W.
Kilian B.
Quintais L.T.
Guerra-Assuncao J.A.
Zhou Y.
Gu Y.
Yen J.
Vogel J.H.
Eyre T.
Redmond S.
Banerjee R.
Chi J.
Fu B.
Langley E.
Maguire S.F.
Laird G.K.
Lloyd D.
Kenyon E.
Donaldson S.
Sehra H.
Almeida-King J.
Loveland J.
Trevanion S.
Jones M.
Quail M.
Willey D.
Hunt A.
Burton J.
Sims S.
McLay K.
Plumb B.
Davis J.
Clee C.
Oliver K.
Clark R.
Riddle C.
Elliot D.
Eliott D.
Threadgold G.
Harden G.
Ware D.
Begum S.
Mortimore B.
Mortimer B.
Kerry G.
Heath P.
Phillimore B.
Tracey A.
Corby N.
Dunn M.
Johnson C.
Wood J.
Clark S.
Pelan S.
Griffiths G.
Smith M.
Glithero R.
Howden P.
Barker N.
Lloyd C.
Stevens C.
Harley J.
Holt K.
Panagiotidis G.
Lovell J.
Beasley H.
Henderson C.
Gordon D.
Auger K.
Wright D.
Collins J.
Raisen C.
Dyer L.
Leung K.
Robertson L.
Ambridge K.
Leongamornlert D.
McGuire S.
Gilderthorp R.
Griffiths C.
Manthravadi D.
Nichol S.
Barker G.
Whitehead S.
Kay M.
Brown J.
Murnane C.
Gray E.
Humphries M.
Sycamore N.
Barker D.
Saunders D.
Wallis J.
Babbage A.
Hammond S.
Mashreghi-Mohammadi M.
Barr L.
Martin S.
Wray P.
Ellington A.
Matthews N.
Ellwood M.
Woodmansey R.
Clark G.
Cooper J.
Cooper J.
Tromans A.
Grafham D.
Skuce C.
Pandian R.
Andrews R.
Harrison E.
Kimberley A.
Garnett J.
Fosker N.
Hall R.
Garner P.
Kelly D.
Bird C.
Palmer S.
Gehring I.
Berger A.
Dooley C.M.
Ersan-Urun Z.
Eser C.
Geiger H.
Geisler M.
Karotki L.
Kirn A.
Konantz J.
Konantz M.
Oberlander M.
Rudolph-Geiger S.
Teucke M.
Lanz C.
Raddatz G.
Osoegawa K.
Zhu B.
Rapp A.
Widaa S.
Langford C.
Yang F.
Schuster S.C.
Carter N.P.
Harrow J.
Ning Z.
Herrero J.
Searle S.M.
Enright A.
Geisler R.
Plasterk R.H.
Lee C.
Westerfield M.
de Jong P.J.
Zon L.I.
Postlethwait J.H.
Nusslein-Volhard C.
Hubbard T.J.
Roest Crollius H.
Rogers J.
Stemple D.L.

The zebrafish reference genome sequence and its relationship to the human genome.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Sternorrhyncha Coccoidea Pseudococcidae Maconellicoccus

axial binding residue

Selvamani S.B.
Negi N.
Nagarjuna Reddy K.V.
Ramasamy G.G.

Identification of Cytochrome P450s in Maconellicoccus hirsutus.

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Disordered

Disordered

Disordered

Disordered

Disordered

Polar residues

Low complexity

Polar residues

Low complexity

Polar residues

Low complexity

Polar residues

Low complexity

Low complexity

Low complexity

Polar residues

Low complexity

Polar residues

Polar residues

Polar residues


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Laurasiatheria Artiodactyla Ruminantia Pecora Cervidae Cervinae Cervus


axial binding residue

May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides


Ligated ion channel binding I - glutamate

Helical

Helical

Helical

Helical

Helical

Helical

Helical


Disordered

Lander E.S.
Linton L.M.
Birren B.
Nusbaum C.
Zody M.C.
Baldwin J.
Devon K.
Dewar K.
Doyle M.
FitzHugh W.
Funke R.
Gage D.
Harris K.
Heaford A.
Howland J.
Kann L.
Lehoczky J.
LeVine R.
McEwan P.
McKernan K.
Meldrim J.
Mesirov J.P.
Miranda C.
Morris W.
Naylor J.
Raymond C.
Rosetti M.
Santos R.
Sheridan A.
Sougnez C.
Stange-Thomann N.
Stojanovic N.
Subramanian A.
Wyman D.
Rogers J.
Sulston J.
Ainscough R.
Beck S.
Bentley D.
Burton J.
Clee C.
Carter N.
Coulson A.
Deadman R.
Deloukas P.
Dunham A.
Dunham I.
Durbin R.
French L.
Grafham D.
Gregory S.
Hubbard T.
Humphray S.
Hunt A.
Jones M.
Lloyd C.
McMurray A.
Matthews L.
Mercer S.
Milne S.
Mullikin J.C.
Mungall A.
Plumb R.
Ross M.
Shownkeen R.
Sims S.
Waterston R.H.
Wilson R.K.
Hillier L.W.
McPherson J.D.
Marra M.A.
Mardis E.R.
Fulton L.A.
Chinwalla A.T.
Pepin K.H.
Gish W.R.
Chissoe S.L.
Wendl M.C.
Delehaunty K.D.
Miner T.L.
Delehaunty A.
Kramer J.B.
Cook L.L.
Fulton R.S.
Johnson D.L.
Minx P.J.
Clifton S.W.
Hawkins T.
Branscomb E.
Predki P.
Richardson P.
Wenning S.
Slezak T.
Doggett N.
Cheng J.F.
Olsen A.
Lucas S.
Elkin C.
Uberbacher E.
Frazier M.
Gibbs R.A.
Muzny D.M.
Scherer S.E.
Bouck J.B.
Sodergren E.J.
Worley K.C.
Rives C.M.
Gorrell J.H.
Metzker M.L.
Naylor S.L.
Kucherlapati R.S.
Nelson D.L.
Weinstock G.M.
Sakaki Y.
Fujiyama A.
Hattori M.
Yada T.
Toyoda A.
Itoh T.
Kawagoe C.
Watanabe H.
Totoki Y.
Taylor T.
Weissenbach J.
Heilig R.
Saurin W.
Artiguenave F.
Brottier P.
Bruls T.
Pelletier E.
Robert C.
Wincker P.
Smith D.R.
Doucette-Stamm L.
Rubenfield M.
Weinstock K.
Lee H.M.
Dubois J.
Rosenthal A.
Platzer M.
Nyakatura G.
Taudien S.
Rump A.
Yang H.
Yu J.
Wang J.
Huang G.
Gu J.
Hood L.
Rowen L.
Madan A.
Qin S.
Davis R.W.
Federspiel N.A.
Abola A.P.
Proctor M.J.
Myers R.M.
Schmutz J.
Dickson M.
Grimwood J.
Cox D.R.
Olson M.V.
Kaul R.
Raymond C.
Shimizu N.
Kawasaki K.
Minoshima S.
Evans G.A.
Athanasiou M.
Schultz R.
Roe B.A.
Chen F.
Pan H.
Ramser J.
Lehrach H.
Reinhardt R.
McCombie W.R.
de la Bastide M.
Dedhia N.
Blocker H.
Hornischer K.
Nordsiek G.
Agarwala R.
Aravind L.
Bailey J.A.
Bateman A.
Batzoglou S.
Birney E.
Bork P.
Brown D.G.
Burge C.B.
Cerutti L.
Chen H.C.
Church D.
Clamp M.
Copley R.R.
Doerks T.
Eddy S.R.
Eichler E.E.
Furey T.S.
Galagan J.
Gilbert J.G.
Harmon C.
Hayashizaki Y.
Haussler D.
Hermjakob H.
Hokamp K.
Jang W.
Johnson L.S.
Jones T.A.
Kasif S.
Kaspryzk A.
Kennedy S.
Kent W.J.
Kitts P.
Koonin E.V.
Korf I.
Kulp D.
Lancet D.
Lowe T.M.
McLysaght A.
Mikkelsen T.
Moran J.V.
Mulder N.
Pollara V.J.
Ponting C.P.
Schuler G.
Schultz J.
Slater G.
Smit A.F.
Stupka E.
Szustakowski J.
Thierry-Mieg D.
Thierry-Mieg J.
Wagner L.
Wallis J.
Wheeler R.
Williams A.
Wolf Y.I.
Wolfe K.H.
Yang S.P.
Yeh R.F.
Collins F.
Guyer M.S.
Peterson J.
Felsenfeld A.
Wetterstrand K.A.
Patrinos A.
Morgan M.J.
de Jong P.
Catanese J.J.
Osoegawa K.
Shizuya H.
Choi S.
Chen Y.J.

Initial sequencing and analysis of the human genome.

Humphray S.J.
Oliver K.
Hunt A.R.
Plumb R.W.
Loveland J.E.
Howe K.L.
Andrews T.D.
Searle S.
Hunt S.E.
Scott C.E.
Jones M.C.
Ainscough R.
Almeida J.P.
Ambrose K.D.
Ashwell R.I.
Babbage A.K.
Babbage S.
Bagguley C.L.
Bailey J.
Banerjee R.
Barker D.J.
Barlow K.F.
Bates K.
Beasley H.
Beasley O.
Bird C.P.
Bray-Allen S.
Brown A.J.
Brown J.Y.
Burford D.
Burrill W.
Burton J.
Carder C.
Carter N.P.
Chapman J.C.
Chen Y.
Clarke G.
Clark S.Y.
Clee C.M.
Clegg S.
Collier R.E.
Corby N.
Crosier M.
Cummings A.T.
Davies J.
Dhami P.
Dunn M.
Dutta I.
Dyer L.W.
Earthrowl M.E.
Faulkner L.
Fleming C.J.
Frankish A.
Frankland J.A.
French L.
Fricker D.G.
Garner P.
Garnett J.
Ghori J.
Gilbert J.G.
Glison C.
Grafham D.V.
Gribble S.
Griffiths C.
Griffiths-Jones S.
Grocock R.
Guy J.
Hall R.E.
Hammond S.
Harley J.L.
Harrison E.S.
Hart E.A.
Heath P.D.
Henderson C.D.
Hopkins B.L.
Howard P.J.
Howden P.J.
Huckle E.
Johnson C.
Johnson D.
Joy A.A.
Kay M.
Keenan S.
Kershaw J.K.
Kimberley A.M.
King A.
Knights A.
Laird G.K.
Langford C.
Lawlor S.
Leongamornlert D.A.
Leversha M.
Lloyd C.
Lloyd D.M.
Lovell J.
Martin S.
Mashreghi-Mohammadi M.
Matthews L.
McLaren S.
McLay K.E.
McMurray A.
Milne S.
Nickerson T.
Nisbett J.
Nordsiek G.
Pearce A.V.
Peck A.I.
Porter K.M.
Pandian R.
Pelan S.
Phillimore B.
Povey S.
Ramsey Y.
Rand V.
Scharfe M.
Sehra H.K.
Shownkeen R.
Sims S.K.
Skuce C.D.
Smith M.
Steward C.A.
Swarbreck D.
Sycamore N.
Tester J.
Thorpe A.
Tracey A.
Tromans A.
Thomas D.W.
Wall M.
Wallis J.M.
West A.P.
Whitehead S.L.
Willey D.L.
Williams S.A.
Wilming L.
Wray P.W.
Young L.
Ashurst J.L.
Coulson A.
Blocker H.
Durbin R.
Sulston J.E.
Hubbard T.
Jackson M.J.
Bentley D.R.
Beck S.
Rogers J.
Dunham I.

DNA sequence and analysis of human chromosome 9.

Finishing the euchromatic sequence of the human genome.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Hymenoptera Apocrita Aculeata Apoidea Anthophila Apidae Xylocopa Koptortosoma

Proline amide

Shi N.
Szanto T.G.
He J.
Schroeder C.I.
Walker A.A.
Deuis J.R.
Vetter I.
Panyi G.
King G.F.
Robinson S.D.

Venom composition and pain-causing toxins of the Australian great carpenter bee Xylocopa aruana.

NUCLEOTIDE SEQUENCE [MRNA]
PROTEIN SEQUENCE OF 34-50
IDENTIFICATION BY MASS SPECTROMETRY
SUBCELLULAR LOCATION
AMIDATION AT PRO-50
SYNTHESIS OF 34-50
FUNCTION
BIOASSAY

Cytotoxin that provokes cell lysis. Induces leak currents in cell membranes in the same way as melittin, suggesting a membrane disrupting mode of action. Also activates DRG neurons. DRG activation and cell lysis is potentiated by phospholipase A2 (PA2). In vivo, intraplantar injection in mice causes spontaneous pain behaviors and paw swelling, which are also potentiated by PA2 coinjection


Eukaryota
Fungi
Dikarya
Ascomycota
Pezizomycotina
Eurotiomycetes
Eurotiomycetidae
Eurotiales
Aspergillaceae
Aspergillus
Aspergillus subgen. Circumdati

Arginine-containing cyclodipeptide synthase ateA

Disordered

Conserved DDXXE motif

Polar residues

Yee D.A.
Niwa K.
Perlatti B.
Chen M.
Li Y.
Tang Y.

Genome mining for unknown-unknown natural products.

NUCLEOTIDE SEQUENCE [MRNA]
FUNCTION
CATALYTIC ACTIVITY
PATHWAY

Arginine-containing cyclodipeptide synthase; part of the cluster that mediates the biosynthesis of a highly modified cyclo-arginine-glutamate dipeptide (cRE) (PubMed:36702957). Within the pathway, ateA acts as the scaffold-generating enzyme and is responsible for formation of the cyclo-Arg-Glu diketopiperazine (cRW) from L-arginyl-tRNA(Arg) + L-glutamyl-tRNA(Glu) (PubMed:36702957). Additional enzymes from the cluster then further modify the cyclo-Arg-Glu diketopiperazine (cRW) scaffold (Probable)

L-glutamyl-tRNA(Glu) + L-arginyl-tRNA(Arg) = cyclo(L-arginyl-L-glutamyl) + tRNA(Glu) + tRNA(Arg) + 2 H(+)

The conserved DDXXE motif is essential for catalytic activity

Belongs to the arginine-containing cyclodipeptide synthase family


Sulfotransferase

P-loop containing nucleotide triphosphate hydrolases

P-loop containing nucleoside triphosphate hydrolases

Belongs to the sulfotransferase 1 family


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Polychaeta Sedentaria Canalipalpata Sabellida Siboglinidae Ridgeia

Chitin-binding type-2

Ig-like

Perez M.
Aroh O.
Sun Y.
Lan Y.
Juniper S.K.
Young C.R.
Angers B.
Qian P.Y.

Third-Generation Sequencing Reveals the Adaptive Role of the Epigenome in Three Deep-Sea Polychaetes.

CARTILAGE INTERMEDIATE LAYER PROTEIN 1-LIKE ISOFORM X1

CARTILAGE INTERMEDIATE LAYER PROTEIN CLIP

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Leucinodes

Helical

Helical

Helical

Helical

Pathak J.
Thiruvengadam V.
Gracy G.R.
M M.


Zdenek C.N.
Cardoso F.C.
Robinson S.D.
Mercedes R.S.
Raidjoe E.R.
Hernandez-Vargas M.J.
Jin J.
Corzo G.
Vetter I.
King G.F.
Fry B.G.
Walker A.

Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Megaloptera Corydalidae Corydalinae Protohermes

Helical

Helical

Helical

Helical

Yang J.
Wen X.
Zou J.
Huang X.
Wu T.
Huang X.

De novo transcriptome analysis of Protohermes xanthodes Navas (Megaloptera: Corydalidae) reveling the effects of sublethal chlorpyrifos on the expression of cholinergic neuronal genes.

F:extracellular ligand-gated monoatomic ion channel activity

F:transmembrane signaling receptor activity

Neurotransmitter-gated ion-channel ligand-binding domain

Neurotransmitter-gated ion-channel transmembrane domain

Neurotransmitter-gated ion-channel transmembrane pore

Nicotinic receptor ligand binding domain-like


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Acari Acariformes Trombidiformes Prostigmata Eleutherengona Heterostigmata Tarsonemoidea Tarsonemidae Polyphagotarsonemus

Ligated ion channel binding I - glutamate

Helical

Helical

Helical

Helical

Helical


Eukaryota Cryptophyceae Pyrenomonadales Chroomonadaceae Chroomonas

Helical

Photosystem II reaction center protein M, PsbM


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Coleoptera Polyphaga Staphyliniformia Silphidae Nicrophorinae Nicrophorus

Cyclic GMP-AMP synthase-like receptor

Cunningham C.B.
Li L.
Wiberg R.A.
Shelton J.M.
Mckinney E.C.
Parker D.J.
Meagher R.B.
Benowitz K.M.
Roy-Zokan E.M.
Ritchie M.G.
Brown S.J.
Schmitz R.B.
Moore A.J.

The Nicrophorus vespilloides genome and methylome, a beetle with complex social behavior.

Li Y.
Slavik K.M.
Toyoda H.C.
Morehouse B.R.
de Oliveira Mann C.C.
Elek A.
Levy S.
Wang Z.
Mears K.S.
Liu J.
Kashin D.
Guo X.
Mass T.
Sebe-Pedros A.
Schwede F.
Kranzusch P.J.

cGLRs are a diverse family of pattern recognition receptors in innate immunity.

F:2',3'-cyclic GMP-AMP synthase activity

CELL FATE DETERMINING PROTEIN MAB21-RELATED

CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED

Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:37379839). Acts as a key sensor of double-stranded RNA (dsRNA), the presence of dsRNA in the cytoplasm being a danger signal that triggers the immune responses (PubMed:37379839). Directly binds dsRNA, activating the nucleotidyltransferase activity, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates Sting, thereby triggering the immune response via activation of the NF-kappa-B transcription factor (PubMed:37379839)

pppGp(2'-5')A = 2',3'-cGAMP + diphosphate


Helical

Helical

Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Pentatomomorpha Pentatomoidea Pentatomidae Asopinae Eocanthecona

Pheromone/general odorant binding protein domain


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Pleocyemata Brachyura Eubrachyura Potamoidea Potamidae Tenuipotamon

Shi B.Y.
Pan D.
Zhang K.Q.
Gu T.Y.
Yeo D.C.J.
Ng P.K.L.
Cumberlidge N.
Sun H.Y.

Diversification of freshwater crabs on the sky islands in the Hengduan Mountains Region, China.


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae asterids lamiids Lamiales Gesneriaceae Didymocarpoideae Epithemateae Monophyllaeinae Monophyllaea

NAC

Nakamura S.
Kinoshita A.
Koga H.
Tsukaya H.

Neotenic meristem found from expression of CUP-SHAPED COTYLEDON and SHOOT MERISTEMLESS in the one-leaf plant, Monophyllaea glabra.

F:transcription cis-regulatory region binding

P:regulation of DNA-templated transcription


Helical

Helical

Helical


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo

Splicing regulatory small protein

Disordered

Mediates interaction with SRSF3

Disordered

Basic residues

Basic and acidic residues

Polar residues

Hillier L.W.
Graves T.A.
Fulton R.S.
Fulton L.A.
Pepin K.H.
Minx P.
Wagner-McPherson C.
Layman D.
Wylie K.
Sekhon M.
Becker M.C.
Fewell G.A.
Delehaunty K.D.
Miner T.L.
Nash W.E.
Kremitzki C.
Oddy L.
Du H.
Sun H.
Bradshaw-Cordum H.
Ali J.
Carter J.
Cordes M.
Harris A.
Isak A.
van Brunt A.
Nguyen C.
Du F.
Courtney L.
Kalicki J.
Ozersky P.
Abbott S.
Armstrong J.
Belter E.A.
Caruso L.
Cedroni M.
Cotton M.
Davidson T.
Desai A.
Elliott G.
Erb T.
Fronick C.
Gaige T.
Haakenson W.
Haglund K.
Holmes A.
Harkins R.
Kim K.
Kruchowski S.S.
Strong C.M.
Grewal N.
Goyea E.
Hou S.
Levy A.
Martinka S.
Mead K.
McLellan M.D.
Meyer R.
Randall-Maher J.
Tomlinson C.
Dauphin-Kohlberg S.
Kozlowicz-Reilly A.
Shah N.
Swearengen-Shahid S.
Snider J.
Strong J.T.
Thompson J.
Yoakum M.
Leonard S.
Pearman C.
Trani L.
Radionenko M.
Waligorski J.E.
Wang C.
Rock S.M.
Tin-Wollam A.-M.
Maupin R.
Latreille P.
Wendl M.C.
Yang S.-P.
Pohl C.
Wallis J.W.
Spieth J.
Bieri T.A.
Berkowicz N.
Nelson J.O.
Osborne J.
Ding L.
Meyer R.
Sabo A.
Shotland Y.
Sinha P.
Wohldmann P.E.
Cook L.L.
Hickenbotham M.T.
Eldred J.
Williams D.
Jones T.A.
She X.
Ciccarelli F.D.
Izaurralde E.
Taylor J.
Schmutz J.
Myers R.M.
Cox D.R.
Huang X.
McPherson J.D.
Mardis E.R.
Clifton S.W.
Warren W.C.
Chinwalla A.T.
Eddy S.R.
Marra M.A.
Ovcharenko I.
Furey T.S.
Miller W.
Eichler E.E.
Bork P.
Suyama M.
Torrents D.
Waterston R.H.
Wilson R.K.

Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

Meng N.
Chen M.
Chen D.
Chen X.H.
Wang J.Z.
Zhu S.
He Y.T.
Zhang X.L.
Lu R.X.
Yan G.R.

Small protein hidden in lncRNA LOC90024 promotes 'cancerous' RNA splicing and tumorigenesis.

IDENTIFICATION BY MASS SPECTROMETRY
FUNCTION
INTERACTION WITH SRSF3
REGION

Interacts with the splicing factor SRSF3 and increases its binding to specific exons within pre-mRNA, thereby regulating exon-inclusion during alternative splicing (PubMed:32440474). Does not directly bind pre-mRNA and could regulate a wider range of splicing factors through a similar mechanism (PubMed:32440474)

Interacts with SRSF3; increases SRSF3 binding to specific exons


Eukaryota Metazoa Echinodermata Eleutherozoa Echinozoa Holothuroidea Aspidochirotacea Aspidochirotida Stichopodidae Apostichopus

Guanylate-binding protein N-terminal

Guanylate-binding protein/Atlastin C-terminal

P-loop containing nucleotide triphosphate hydrolases

Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain

P-loop containing nucleoside triphosphate hydrolases


Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Bivalvia Autobranchia Pteriomorphia Pterioida Pterioidea Pteriidae Pinctada

Helical

THD

Characterism and functional analysis of a novel tumor necrosis factor from pearl oyster Pinctada fucata martensii.

F:tumor necrosis factor receptor binding

TNF FAMILY PROFILE DOMAIN-CONTAINING PROTEIN

Belongs to the tumor necrosis factor family


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Pleocyemata Brachyura Eubrachyura Grapsoidea Varunidae Eriocheir

Integration of transcriptomics and proteomics analysis reveals the molecular mechanism of Eriocheir sinensis gills exposed to heat stress.


Disordered

Initial sequencing and analysis of the human genome.

Martin J.
Han C.
Gordon L.A.
Terry A.
Prabhakar S.
She X.
Xie G.
Hellsten U.
Chan Y.M.
Altherr M.
Couronne O.
Aerts A.
Bajorek E.
Black S.
Blumer H.
Branscomb E.
Brown N.C.
Bruno W.J.
Buckingham J.M.
Callen D.F.
Campbell C.S.
Campbell M.L.
Campbell E.W.
Caoile C.
Challacombe J.F.
Chasteen L.A.
Chertkov O.
Chi H.C.
Christensen M.
Clark L.M.
Cohn J.D.
Denys M.
Detter J.C.
Dickson M.
Dimitrijevic-Bussod M.
Escobar J.
Fawcett J.J.
Flowers D.
Fotopulos D.
Glavina T.
Gomez M.
Gonzales E.
Goodstein D.
Goodwin L.A.
Grady D.L.
Grigoriev I.
Groza M.
Hammon N.
Hawkins T.
Haydu L.
Hildebrand C.E.
Huang W.
Israni S.
Jett J.
Jewett P.B.
Kadner K.
Kimball H.
Kobayashi A.
Krawczyk M.C.
Leyba T.
Longmire J.L.
Lopez F.
Lou Y.
Lowry S.
Ludeman T.
Manohar C.F.
Mark G.A.
McMurray K.L.
Meincke L.J.
Morgan J.
Moyzis R.K.
Mundt M.O.
Munk A.C.
Nandkeshwar R.D.
Pitluck S.
Pollard M.
Predki P.
Parson-Quintana B.
Ramirez L.
Rash S.
Retterer J.
Ricke D.O.
Robinson D.L.
Rodriguez A.
Salamov A.
Saunders E.H.
Scott D.
Shough T.
Stallings R.L.
Stalvey M.
Sutherland R.D.
Tapia R.
Tesmer J.G.
Thayer N.
Thompson L.S.
Tice H.
Torney D.C.
Tran-Gyamfi M.
Tsai M.
Ulanovsky L.E.
Ustaszewska A.
Vo N.
White P.S.
Williams A.L.
Wills P.L.
Wu J.R.
Wu K.
Yang J.
Dejong P.
Bruce D.
Doggett N.A.
Deaven L.
Schmutz J.
Grimwood J.
Richardson P.
Rokhsar D.S.
Eichler E.E.
Gilna P.
Lucas S.M.
Myers R.M.
Rubin E.M.
Pennacchio L.A.

The sequence and analysis of duplication-rich human chromosome 16.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Polyneoptera Orthoptera Caelifera Acrididea Acridomorpha Acridoidea Acrididae Oedipodinae Locusta

Ubiquitin-like

Disordered

Disordered

Disordered

Polar residues

Gly residues

Identification and Expression Profile Analysis of Tudor Family Genes in Locusta migratoria, and Functional Characterization of LmTdr7.

Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Neopterygii Teleostei Ostariophysi Cypriniformes Danionidae Danioninae Danio

Helical

Helical

Distal membrane-arm assembly complex protein 1-like

Strausberg R.L.
Feingold E.A.
Grouse L.H.
Derge J.G.
Klausner R.D.
Collins F.S.
Wagner L.
Shenmen C.M.
Schuler G.D.
Altschul S.F.
Zeeberg B.
Buetow K.H.
Schaefer C.F.
Bhat N.K.
Hopkins R.F.
Jordan H.
Moore T.
Max S.I.
Wang J.
Hsieh F.
Diatchenko L.
Marusina K.
Farmer A.A.
Rubin G.M.
Hong L.
Stapleton M.
Soares M.B.
Bonaldo M.F.
Casavant T.L.
Scheetz T.E.
Brownstein M.J.
Usdin T.B.
Toshiyuki S.
Carninci P.
Prange C.
Raha S.S.
Loquellano N.A.
Peters G.J.
Abramson R.D.
Mullahy S.J.
Bosak S.A.
McEwan P.J.
McKernan K.J.
Malek J.A.
Gunaratne P.H.
Richards S.
Worley K.C.
Hale S.
Garcia A.M.
Gay L.J.
Hulyk S.W.
Villalon D.K.
Muzny D.M.
Sodergren E.J.
Lu X.
Gibbs R.A.
Fahey J.
Helton E.
Ketteman M.
Madan A.
Rodrigues S.
Sanchez A.
Whiting M.
Madan A.
Young A.C.
Shevchenko Y.
Bouffard G.G.
Blakesley R.W.
Touchman J.W.
Green E.D.
Dickson M.C.
Rodriguez A.C.
Grimwood J.
Schmutz J.
Myers R.M.
Butterfield Y.S.
Krzywinski M.I.
Skalska U.
Smailus D.E.
Schnerch A.
Schein J.E.
Jones S.J.
Marra M.A.

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.

Gaudet P.
Livstone M.S.
Lewis S.E.
Thomas P.D.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.


Adenomatous polyposis coli N-terminal dimerisation

Lander E.S.
Linton L.M.
Birren B.
Nusbaum C.
Zody M.C.
Baldwin J.
Devon K.
Dewar K.
Doyle M.
FitzHugh W.
Funke R.
Gage D.
Harris K.
Heaford A.
Howland J.
Kann L.
Lehoczky J.
LeVine R.
McEwan P.
McKernan K.
Meldrim J.
Mesirov J.P.
Miranda C.
Morris W.
Naylor J.
Raymond C.
Rosetti M.
Santos R.
Sheridan A.
Sougnez C.
Stange-Thomann N.
Stojanovic N.
Subramanian A.
Wyman D.
Rogers J.
Sulston J.
Ainscough R.
Beck S.
Bentley D.
Burton J.
Clee C.
Carter N.
Coulson A.
Deadman R.
Deloukas P.
Dunham A.
Dunham I.
Durbin R.
French L.
Grafham D.
Gregory S.
Hubbard T.
Humphray S.
Hunt A.
Jones M.
Lloyd C.
McMurray A.
Matthews L.
Mercer S.
Milne S.
Mullikin J.C.
Mungall A.
Plumb R.
Ross M.
Shownkeen R.
Sims S.
Waterston R.H.
Wilson R.K.
Hillier L.W.
McPherson J.D.
Marra M.A.
Mardis E.R.
Fulton L.A.
Chinwalla A.T.
Pepin K.H.
Gish W.R.
Chissoe S.L.
Wendl M.C.
Delehaunty K.D.
Miner T.L.
Delehaunty A.
Kramer J.B.
Cook L.L.
Fulton R.S.
Johnson D.L.
Minx P.J.
Clifton S.W.
Hawkins T.
Branscomb E.
Predki P.
Richardson P.
Wenning S.
Slezak T.
Doggett N.
Cheng J.F.
Olsen A.
Lucas S.
Elkin C.
Uberbacher E.
Frazier M.
Gibbs R.A.
Muzny D.M.
Scherer S.E.
Bouck J.B.
Sodergren E.J.
Worley K.C.
Rives C.M.
Gorrell J.H.
Metzker M.L.
Naylor S.L.
Kucherlapati R.S.
Nelson D.L.
Weinstock G.M.
Sakaki Y.
Fujiyama A.
Hattori M.
Yada T.
Toyoda A.
Itoh T.
Kawagoe C.
Watanabe H.
Totoki Y.
Taylor T.
Weissenbach J.
Heilig R.
Saurin W.
Artiguenave F.
Brottier P.
Bruls T.
Pelletier E.
Robert C.
Wincker P.
Smith D.R.
Doucette-Stamm L.
Rubenfield M.
Weinstock K.
Lee H.M.
Dubois J.
Rosenthal A.
Platzer M.
Nyakatura G.
Taudien S.
Rump A.
Yang H.
Yu J.
Wang J.
Huang G.
Gu J.
Hood L.
Rowen L.
Madan A.
Qin S.
Davis R.W.
Federspiel N.A.
Abola A.P.
Proctor M.J.
Myers R.M.
Schmutz J.
Dickson M.
Grimwood J.
Cox D.R.
Olson M.V.
Kaul R.
Raymond C.
Shimizu N.
Kawasaki K.
Minoshima S.
Evans G.A.
Athanasiou M.
Schultz R.
Roe B.A.
Chen F.
Pan H.
Ramser J.
Lehrach H.
Reinhardt R.
McCombie W.R.
de la Bastide M.
Dedhia N.
Blocker H.
Hornischer K.
Nordsiek G.
Agarwala R.
Aravind L.
Bailey J.A.
Bateman A.
Batzoglou S.
Birney E.
Bork P.
Brown D.G.
Burge C.B.
Cerutti L.
Chen H.C.
Church D.
Clamp M.
Copley R.R.
Doerks T.
Eddy S.R.
Eichler E.E.
Furey T.S.
Galagan J.
Gilbert J.G.
Harmon C.
Hayashizaki Y.
Haussler D.
Hermjakob H.
Hokamp K.
Jang W.
Johnson L.S.
Jones T.A.
Kasif S.
Kaspryzk A.
Kennedy S.
Kent W.J.
Kitts P.
Koonin E.V.
Korf I.
Kulp D.
Lancet D.
Lowe T.M.
McLysaght A.
Mikkelsen T.
Moran J.V.
Mulder N.
Pollara V.J.
Ponting C.P.
Schuler G.
Schultz J.
Slater G.
Smit A.F.
Stupka E.
Szustakowski J.
Thierry-Mieg D.
Thierry-Mieg J.
Wagner L.
Wallis J.
Wheeler R.
Williams A.
Wolf Y.I.
Wolfe K.H.
Yang S.P.
Yeh R.F.
Collins F.
Guyer M.S.
Peterson J.
Felsenfeld A.
Wetterstrand K.A.
Patrinos A.
Morgan M.J.
de Jong P.
Catanese J.J.
Osoegawa K.
Shizuya H.
Choi S.
Chen Y.J.

Schmutz J.
Martin J.
Terry A.
Couronne O.
Grimwood J.
Lowry S.
Gordon L.A.
Scott D.
Xie G.
Huang W.
Hellsten U.
Tran-Gyamfi M.
She X.
Prabhakar S.
Aerts A.
Altherr M.
Bajorek E.
Black S.
Branscomb E.
Caoile C.
Challacombe J.F.
Chan Y.M.
Denys M.
Detter J.C.
Escobar J.
Flowers D.
Fotopulos D.
Glavina T.
Gomez M.
Gonzales E.
Goodstein D.
Grigoriev I.
Groza M.
Hammon N.
Hawkins T.
Haydu L.
Israni S.
Jett J.
Kadner K.
Kimball H.
Kobayashi A.
Lopez F.
Lou Y.
Martinez D.
Medina C.
Morgan J.
Nandkeshwar R.
Noonan J.P.
Pitluck S.
Pollard M.
Predki P.
Priest J.
Ramirez L.
Retterer J.
Rodriguez A.
Rogers S.
Salamov A.
Salazar A.
Thayer N.
Tice H.
Tsai M.
Ustaszewska A.
Vo N.
Wheeler J.
Wu K.
Yang J.
Dickson M.
Cheng J.F.
Eichler E.E.
Olsen A.
Pennacchio L.A.
Rokhsar D.S.
Richardson P.
Lucas S.M.
Myers R.M.
Rubin E.M.

The DNA sequence and comparative analysis of human chromosome 5.

Finishing the euchromatic sequence of the human genome.

P:negative regulation of Wnt signaling pathway

adenomatous polyposis coli protein-like isoform X1

ADENOMATOUS POLYPOSIS COLI PROTEIN FAMILY


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Clitellata Oligochaeta Enchytraeida Enchytraeidae Enchytraeus

Nanos-type

Kostyuchenko R.P.
Nikanorova D.D.
Amosov A.V.

Germ Line/Multipotency Genes Show Differential Expression during Embryonic Development of the Annelid Enchytraeus coronatus.


Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Bivalvia Autobranchia Heteroconchia Palaeoheterodonta Unionida Unionoidea Unionidae Gonideinae Sinohyriopsis

DM

DM

Disordered

Disordered

Polar residues

Polar residues

F:DNA-binding transcription factor activity, RNA polymerase II-specific

F:RNA polymerase II cis-regulatory region sequence-specific DNA binding

DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT

Cysteine-rich DNA binding domain, (DM domain)


Eukaryota Metazoa Porifera Calcarea Calcinea Clathrinida Leucettidae Leucetta

BZIP

Gene networks governing the response of a calcareous sponge to future ocean conditions reveal lineage-specific XBP1 regulation of the unfolded protein response.

F:RNA polymerase II transcription regulatory region sequence-specific DNA binding


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Stenopodainae Oncocephalus

CUB

Peptidase S1

Disordered

Basic and acidic residues

Basic and acidic residues

Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).

Lacks conserved residue(s) required for the propagation of feature annotation


Epithelial sodium channel/degenerin-like protein

Helical

Helical

Disordered

Polar residues

Basic residues

Basic residues

Polar residues

Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).

Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family


Bacteria Pseudomonadati Pseudomonadota Gammaproteobacteria Oceanospirillales Hahellaceae Hahella

Hu W.
Yang B.
Xiao Q.
Wang Y.
Shuai Y.
Zhao G.
Zhang L.
Deng Z.
He X.
Liu G.

Characterization of a promiscuous DNA sulfur binding domain and application in site-directed RNA base editing.

X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH MG(2+)


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Neopterygii Teleostei Neoteleostei Acanthomorphata Gobiaria Gobiiformes Gobioidei Gobiidae Gobiinae Knipowitschia

Ig-like

CARTILAGE INTERMEDIATE LAYER PROTEIN CLIP

Secreted, extracellular space, extracellular matrix


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Zygaenoidea Megalopygidae Megalopyge

Walker A.A.
Robinson S.D.
Merritt D.J.
Cardoso F.C.
Goudarzi M.H.
Mercedes R.S.
Eagles D.A.
Cooper P.
Zdenek C.N.
Fry B.G.
Hall D.W.
Vetter I.
King G.F.

Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae).

NUCLEOTIDE SEQUENCE [MRNA]
MASS SPECTROMETRY
SYNTHESIS OF 30-55
SUBCELLULAR LOCATION
TISSUE SPECIFICITY
DEVELOPMENTAL STAGE


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae asterids lamiids Gentianales Apocynaceae Asclepiadoideae Marsdenieae Gymnema

WRKY

WRKY

Disordered

Disordered

Polar residues

Polar residues

Transcriptomic revealing of plant pathogen interaction in Gymnema sylvestre.

F:DNA-binding transcription factor activity

WRKY TRANSCRIPTION FACTOR PROTEIN 1-RELATED


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Sternorrhyncha Coccoidea Pseudococcidae Maconellicoccus

axial binding residue

Selvamani S.B.
Negi N.
Nagarjuna Reddy K.V.
Ramasamy G.G.

Identification of Cytochrome P450s in Maconellicoccus hirsutus.

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Eukaryota Metazoa Porifera Demospongiae Verongimorpha Chondrillida Halisarcidae Halisarca

Disordered

Disordered

Disordered

Polar residues

Acidic residues

axial binding residue

Haem peroxidase domain superfamily, animal type


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae Saxifragales Paeoniaceae Paeonia

Transposase Tnp1/En/Spm-like domain-containing protein

Disordered

Disordered

Basic residues

Basic and acidic residues

Acidic residues

Basic residues


Howe K.
Clark M.D.
Torroja C.F.
Torrance J.
Berthelot C.
Muffato M.
Collins J.E.
Humphray S.
McLaren K.
Matthews L.
McLaren S.
Sealy I.
Caccamo M.
Churcher C.
Scott C.
Barrett J.C.
Koch R.
Rauch G.J.
White S.
Chow W.
Kilian B.
Quintais L.T.
Guerra-Assuncao J.A.
Zhou Y.
Gu Y.
Yen J.
Vogel J.H.
Eyre T.
Redmond S.
Banerjee R.
Chi J.
Fu B.
Langley E.
Maguire S.F.
Laird G.K.
Lloyd D.
Kenyon E.
Donaldson S.
Sehra H.
Almeida-King J.
Loveland J.
Trevanion S.
Jones M.
Quail M.
Willey D.
Hunt A.
Burton J.
Sims S.
McLay K.
Plumb B.
Davis J.
Clee C.
Oliver K.
Clark R.
Riddle C.
Elliot D.
Eliott D.
Threadgold G.
Harden G.
Ware D.
Begum S.
Mortimore B.
Mortimer B.
Kerry G.
Heath P.
Phillimore B.
Tracey A.
Corby N.
Dunn M.
Johnson C.
Wood J.
Clark S.
Pelan S.
Griffiths G.
Smith M.
Glithero R.
Howden P.
Barker N.
Lloyd C.
Stevens C.
Harley J.
Holt K.
Panagiotidis G.
Lovell J.
Beasley H.
Henderson C.
Gordon D.
Auger K.
Wright D.
Collins J.
Raisen C.
Dyer L.
Leung K.
Robertson L.
Ambridge K.
Leongamornlert D.
McGuire S.
Gilderthorp R.
Griffiths C.
Manthravadi D.
Nichol S.
Barker G.
Whitehead S.
Kay M.
Brown J.
Murnane C.
Gray E.
Humphries M.
Sycamore N.
Barker D.
Saunders D.
Wallis J.
Babbage A.
Hammond S.
Mashreghi-Mohammadi M.
Barr L.
Martin S.
Wray P.
Ellington A.
Matthews N.
Ellwood M.
Woodmansey R.
Clark G.
Cooper J.
Cooper J.
Tromans A.
Grafham D.
Skuce C.
Pandian R.
Andrews R.
Harrison E.
Kimberley A.
Garnett J.
Fosker N.
Hall R.
Garner P.
Kelly D.
Bird C.
Palmer S.
Gehring I.
Berger A.
Dooley C.M.
Ersan-Urun Z.
Eser C.
Geiger H.
Geisler M.
Karotki L.
Kirn A.
Konantz J.
Konantz M.
Oberlander M.
Rudolph-Geiger S.
Teucke M.
Lanz C.
Raddatz G.
Osoegawa K.
Zhu B.
Rapp A.
Widaa S.
Langford C.
Yang F.
Schuster S.C.
Carter N.P.
Harrow J.
Ning Z.
Herrero J.
Searle S.M.
Enright A.
Geisler R.
Plasterk R.H.
Lee C.
Westerfield M.
de Jong P.J.
Zon L.I.
Postlethwait J.H.
Nusslein-Volhard C.
Hubbard T.J.
Roest Crollius H.
Rogers J.
Stemple D.L.

The zebrafish reference genome sequence and its relationship to the human genome.


MD-2-related lipid-recognition domain-containing protein

MD-2-related lipid-recognition


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo

Gregory S.G.
Barlow K.F.
McLay K.E.
Kaul R.
Swarbreck D.
Dunham A.
Scott C.E.
Howe K.L.
Woodfine K.
Spencer C.C.
Jones M.C.
Gillson C.
Searle S.
Zhou Y.
Kokocinski F.
McDonald L.
Evans R.
Phillips K.
Atkinson A.
Cooper R.
Jones C.
Hall R.E.
Andrews T.D.
Lloyd C.
Ainscough R.
Almeida J.P.
Ambrose K.D.
Anderson F.
Andrew R.W.
Ashwell R.I.
Aubin K.
Babbage A.K.
Bagguley C.L.
Bailey J.
Beasley H.
Bethel G.
Bird C.P.
Bray-Allen S.
Brown J.Y.
Brown A.J.
Buckley D.
Burton J.
Bye J.
Carder C.
Chapman J.C.
Clark S.Y.
Clarke G.
Clee C.
Cobley V.
Collier R.E.
Corby N.
Coville G.J.
Davies J.
Deadman R.
Dunn M.
Earthrowl M.
Ellington A.G.
Errington H.
Frankish A.
Frankland J.
French L.
Garner P.
Garnett J.
Gay L.
Ghori M.R.
Gibson R.
Gilby L.M.
Gillett W.
Glithero R.J.
Grafham D.V.
Griffiths C.
Griffiths-Jones S.
Grocock R.
Hammond S.
Harrison E.S.
Hart E.
Haugen E.
Heath P.D.
Holmes S.
Holt K.
Howden P.J.
Hunt A.R.
Hunt S.E.
Hunter G.
Isherwood J.
James R.
Johnson C.
Johnson D.
Joy A.
Kay M.
Kershaw J.K.
Kibukawa M.
Kimberley A.M.
King A.
Knights A.J.
Lad H.
Laird G.
Lawlor S.
Leongamornlert D.A.
Lloyd D.M.
Loveland J.
Lovell J.
Lush M.J.
Lyne R.
Martin S.
Mashreghi-Mohammadi M.
Matthews L.
Matthews N.S.
McLaren S.
Milne S.
Mistry S.
Moore M.J.
Nickerson T.
O'Dell C.N.
Oliver K.
Palmeiri A.
Palmer S.A.
Parker A.
Patel D.
Pearce A.V.
Peck A.I.
Pelan S.
Phelps K.
Phillimore B.J.
Plumb R.
Rajan J.
Raymond C.
Rouse G.
Saenphimmachak C.
Sehra H.K.
Sheridan E.
Shownkeen R.
Sims S.
Skuce C.D.
Smith M.
Steward C.
Subramanian S.
Sycamore N.
Tracey A.
Tromans A.
Van Helmond Z.
Wall M.
Wallis J.M.
White S.
Whitehead S.L.
Wilkinson J.E.
Willey D.L.
Williams H.
Wilming L.
Wray P.W.
Wu Z.
Coulson A.
Vaudin M.
Sulston J.E.
Durbin R.
Hubbard T.
Wooster R.
Dunham I.
Carter N.P.
McVean G.
Ross M.T.
Harrow J.
Olson M.V.
Beck S.
Rogers J.
Bentley D.R.
Banerjee R.
Bryant S.P.
Burford D.C.
Burrill W.D.
Clegg S.M.
Dhami P.
Dovey O.
Faulkner L.M.
Gribble S.M.
Langford C.F.
Pandian R.D.
Porter K.M.
Prigmore E.

The DNA sequence and biological annotation of human chromosome 1.


Helical

Helical


Eukaryota
Fungi
Dikarya
Ascomycota
Pezizomycotina
Sordariomycetes
Hypocreomycetidae
Glomerellales
Glomerellaceae
Colletotrichum
Colletotrichum acutatum species complex

Key lime anthracnose pathogenicity protein

Zambounis A.
Angeli C.
Tsalgatidou P.
Delis C.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Tineoidea Gracillariidae Conopomorpha


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Thysanoptera Terebrantia Thripoidea Thripidae Thrips

Vitellinogen open beta-sheet

Lipovitellin-phosvitin complex, chain A, domain 4

Lipovitellin-phosvitin complex, beta-sheet shell regions


Serine-rich adhesin for platelets isoform X3


Eukaryota Rhodophyta Florideophyceae Rhodymeniophycidae Gigartinales Solieriaceae Eucheuma

Peptidase C83

Disordered

Functional characterisation of phytochelatin synthase from Eucheuma denticulatum (Rhodophyta).

Phytochelatin synthase, N-terminal domain


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Acari Acariformes Trombidiformes Prostigmata Eleutherengona Heterostigmata Tarsonemoidea Tarsonemidae Polyphagotarsonemus

Helical

Helical

Helical

Helical

Helical

Helical

Helical

G-protein coupled receptors family 1 profile

Disordered

Rhodopsin 7-helix transmembrane proteins

G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED

Family A G protein-coupled receptor-like

Belongs to the G-protein coupled receptor 1 family


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Noctuoidea Noctuidae Hadeninae Mythimna

Helical

Helical

Identification and sex expression profiles of olfactory-related genes in Mythimna loreyi based on antennal transcriptome analysis.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Pentatomomorpha Pyrrhocoroidea Pyrrhocoridae Pyrrhocoris

receptor protein-tyrosine kinase

Helical

Protein kinase

Disordered

Basic and acidic residues

F:transmembrane receptor protein tyrosine kinase activity

P:cell surface receptor protein tyrosine kinase signaling pathway

P:positive regulation of intracellular signal transduction

Proto-oncogene tyrosine-protein kinase receptor Ret

L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Maruca

axial binding residue

C18 oxylipin, EpOME, mediates the immune resolution at late infection stage in the legume pod borer, Maruca vitrata.

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides

an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)


Disordered

F:cellulose synthase (UDP-forming) activity


Helical


Adaptor related protein complex 4 subunit beta 1

Initial sequencing and analysis of the human genome.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Stenopodainae Oncocephalus

Zdenek C.N.
Cardoso F.C.
Robinson S.D.
Mercedes R.S.
Raidjoe E.R.
Hernandez-Vargas M.J.
Jin J.
Corzo G.
Vetter I.
King G.F.
Fry B.G.
Walker A.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Leucinodes

Odorant binding protein/PBP-general odorant binding protein

Pathak J.
Thiruvengadam V.
Gracy G.R.
M M.

Pheromone/general odorant binding protein domain


Disordered

Humphray S.J.
Oliver K.
Hunt A.R.
Plumb R.W.
Loveland J.E.
Howe K.L.
Andrews T.D.
Searle S.
Hunt S.E.
Scott C.E.
Jones M.C.
Ainscough R.
Almeida J.P.
Ambrose K.D.
Ashwell R.I.
Babbage A.K.
Babbage S.
Bagguley C.L.
Bailey J.
Banerjee R.
Barker D.J.
Barlow K.F.
Bates K.
Beasley H.
Beasley O.
Bird C.P.
Bray-Allen S.
Brown A.J.
Brown J.Y.
Burford D.
Burrill W.
Burton J.
Carder C.
Carter N.P.
Chapman J.C.
Chen Y.
Clarke G.
Clark S.Y.
Clee C.M.
Clegg S.
Collier R.E.
Corby N.
Crosier M.
Cummings A.T.
Davies J.
Dhami P.
Dunn M.
Dutta I.
Dyer L.W.
Earthrowl M.E.
Faulkner L.
Fleming C.J.
Frankish A.
Frankland J.A.
French L.
Fricker D.G.
Garner P.
Garnett J.
Ghori J.
Gilbert J.G.
Glison C.
Grafham D.V.
Gribble S.
Griffiths C.
Griffiths-Jones S.
Grocock R.
Guy J.
Hall R.E.
Hammond S.
Harley J.L.
Harrison E.S.
Hart E.A.
Heath P.D.
Henderson C.D.
Hopkins B.L.
Howard P.J.
Howden P.J.
Huckle E.
Johnson C.
Johnson D.
Joy A.A.
Kay M.
Keenan S.
Kershaw J.K.
Kimberley A.M.
King A.
Knights A.
Laird G.K.
Langford C.
Lawlor S.
Leongamornlert D.A.
Leversha M.
Lloyd C.
Lloyd D.M.
Lovell J.
Martin S.
Mashreghi-Mohammadi M.
Matthews L.
McLaren S.
McLay K.E.
McMurray A.
Milne S.
Nickerson T.
Nisbett J.
Nordsiek G.
Pearce A.V.
Peck A.I.
Porter K.M.
Pandian R.
Pelan S.
Phillimore B.
Povey S.
Ramsey Y.
Rand V.
Scharfe M.
Sehra H.K.
Shownkeen R.
Sims S.K.
Skuce C.D.
Smith M.
Steward C.A.
Swarbreck D.
Sycamore N.
Tester J.
Thorpe A.
Tracey A.
Tromans A.
Thomas D.W.
Wall M.
Wallis J.M.
West A.P.
Whitehead S.L.
Willey D.L.
Williams S.A.
Wilming L.
Wray P.W.
Young L.
Ashurst J.L.
Coulson A.
Blocker H.
Durbin R.
Sulston J.E.
Hubbard T.
Jackson M.J.
Bentley D.R.
Beck S.
Rogers J.
Dunham I.

DNA sequence and analysis of human chromosome 9.


Eukaryota Metazoa Spiralia Lophotrochozoa Brachiopoda Craniiformea Craniata Craniida Cranioidea Craniidae Novocrania

Helical

Disordered

Basic and acidic residues

Borve A.
Marti-Solans J.
Lynagh T.
Hejnol A.

Diarylamidine Activation of a Brachiopod DEG/ENaC/ASIC Channel.

AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT GAMMA

Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family


axial binding residue


Helical

Helical

Helical

Helical

Helical

F:ligand-gated monoatomic ion channel activity

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family


Disordered

Basic residues

Finishing the euchromatic sequence of the human genome.

Hillier L.W.
Graves T.A.
Fulton R.S.
Fulton L.A.
Pepin K.H.
Minx P.
Wagner-McPherson C.
Layman D.
Wylie K.
Sekhon M.
Becker M.C.
Fewell G.A.
Delehaunty K.D.
Miner T.L.
Nash W.E.
Kremitzki C.
Oddy L.
Du H.
Sun H.
Bradshaw-Cordum H.
Ali J.
Carter J.
Cordes M.
Harris A.
Isak A.
van Brunt A.
Nguyen C.
Du F.
Courtney L.
Kalicki J.
Ozersky P.
Abbott S.
Armstrong J.
Belter E.A.
Caruso L.
Cedroni M.
Cotton M.
Davidson T.
Desai A.
Elliott G.
Erb T.
Fronick C.
Gaige T.
Haakenson W.
Haglund K.
Holmes A.
Harkins R.
Kim K.
Kruchowski S.S.
Strong C.M.
Grewal N.
Goyea E.
Hou S.
Levy A.
Martinka S.
Mead K.
McLellan M.D.
Meyer R.
Randall-Maher J.
Tomlinson C.
Dauphin-Kohlberg S.
Kozlowicz-Reilly A.
Shah N.
Swearengen-Shahid S.
Snider J.
Strong J.T.
Thompson J.
Yoakum M.
Leonard S.
Pearman C.
Trani L.
Radionenko M.
Waligorski J.E.
Wang C.
Rock S.M.
Tin-Wollam A.M.
Maupin R.
Latreille P.
Wendl M.C.
Yang S.P.
Pohl C.
Wallis J.W.
Spieth J.
Bieri T.A.
Berkowicz N.
Nelson J.O.
Osborne J.
Ding L.
Meyer R.
Sabo A.
Shotland Y.
Sinha P.
Wohldmann P.E.
Cook L.L.
Hickenbotham M.T.
Eldred J.
Williams D.
Jones T.A.
She X.
Ciccarelli F.D.
Izaurralde E.
Taylor J.
Schmutz J.
Myers R.M.
Cox D.R.
Huang X.
McPherson J.D.
Mardis E.R.
Clifton S.W.
Warren W.C.
Chinwalla A.T.
Eddy S.R.
Marra M.A.
Ovcharenko I.
Furey T.S.
Miller W.
Eichler E.E.
Bork P.
Suyama M.
Torrents D.
Waterston R.H.
Wilson R.K.

Generation and annotation of the DNA sequences of human chromosomes 2 and 4.


F:cysteine-type endopeptidase inhibitor activity


Disordered

Low complexity

Basic residues


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Amphibia Batrachia Anura Neobatrachia Microhyloidea Microhylidae Dyscophinae Dyscophus

IgGFc-binding protein N-terminal

IgGFc-binding protein N-terminal

IgGFc-binding protein N-terminal

Disordered

Low complexity

Recurrent evolution of adhesive defence systems in amphibians by parallel shifts in gene expression.


Helical

axial binding residue


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Araneae Araneomorphae Entelegynae Lycosoidea Ctenidae Cupiennius

acetylcholinesterase

Carboxylesterase type B

Acyl-ester intermediate

Charge relay system

Charge relay system

Liu H.
Jang J.
French A.S.
Torkkeli P.H.

Expression and Characterization of Seven Acetylcholine esterases in the Spider Cupiennius salei.

acetylcholine + H2O = choline + acetate + H(+)

Belongs to the type-B carboxylesterase/lipase family


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Polyneoptera Orthoptera Caelifera Acrididea Acridomorpha Acridoidea Acrididae Oedipodinae Locusta

ARID

Disordered

Disordered

Disordered

Disordered

Disordered

Disordered

Disordered

Disordered

Basic and acidic residues

Basic residues

Basic and acidic residues

Basic and acidic residues

Basic and acidic residues

Basic and acidic residues

Polar residues

Low complexity

Basic residues

Low complexity

Acidic residues

Polar residues

Pro residues

Acidic residues

Polar residues

Polar residues

Identification and Expression Profile Analysis of Tudor Family Genes in Locusta migratoria, and Functional Characterization of LmTdr7.

F:transcription cis-regulatory region binding

P:regulation of transcription by RNA polymerase II

AT-rich interactive domain-containing protein 4B


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida Ranunculales Papaveraceae Fumarioideae Corydalis

Helical

Helical

axial binding residue

P:isoquinoline alkaloid biosynthetic process


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Polychaeta Sedentaria Canalipalpata Sabellida Siboglinidae Ridgeia

Ig-like

Disordered

Perez M.
Aroh O.
Sun Y.
Lan Y.
Juniper S.K.
Young C.R.
Angers B.
Qian P.Y.

Third-Generation Sequencing Reveals the Adaptive Role of the Epigenome in Three Deep-Sea Polychaetes.

CARTILAGE INTERMEDIATE LAYER PROTEIN 1-LIKE ISOFORM X1

CARTILAGE INTERMEDIATE LAYER PROTEIN CLIP

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data


Eukaryota Metazoa Porifera Demospongiae Verongimorpha Chondrillida Halisarcidae Halisarca

Fibronectin type-III

Fibronectin type-III

Fibronectin type-III


Deleted in malignant brain tumors 1 protein-like protein 3

SRCR

SRCR

Fibronectin type-III

Scavenger receptor cysteine-rich protein type 12

Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D

Lacks conserved residue(s) required for the propagation of feature annotation


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Coleoptera Polyphaga Cucujiformia Curculionidae Curculioninae Anthonomini Anthonomus

Segura Leon O.L.
Lechuga-Paredes P.
Cibrian Tovar J.
Torres Huerta B.

Lechuga-Paredes P.
Segura-Leon O.L.
Cibrian-Tovar J.
Torres-Huerta B.
Velazquez-Gonzalez J.C.
Cruz-Jaramillo J.L.

Odorant-Binding and Chemosensory Proteins in Anthonomus eugenii (Coleoptera: Curculionidae) and Their Tissue Expression.

Pheromone/general odorant binding protein domain


Helical


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae rosids fabids Rosales Elaeagnaceae Hippophae

MADS-box

Zhao J.
Xu Y.
Zhang Z.
Zhao M.
Li K.
Wang F.
Sun K.

Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.

F:DNA-binding transcription factor activity, RNA polymerase II-specific

F:RNA polymerase II cis-regulatory region sequence-specific DNA binding


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo

Disordered

Acidic residues

Lander E.S.
Linton L.M.
Birren B.
Nusbaum C.
Zody M.C.
Baldwin J.
Devon K.
Dewar K.
Doyle M.
FitzHugh W.
Funke R.
Gage D.
Harris K.
Heaford A.
Howland J.
Kann L.
Lehoczky J.
LeVine R.
McEwan P.
McKernan K.
Meldrim J.
Mesirov J.P.
Miranda C.
Morris W.
Naylor J.
Raymond C.
Rosetti M.
Santos R.
Sheridan A.
Sougnez C.
Stange-Thomann N.
Stojanovic N.
Subramanian A.
Wyman D.
Rogers J.
Sulston J.
Ainscough R.
Beck S.
Bentley D.
Burton J.
Clee C.
Carter N.
Coulson A.
Deadman R.
Deloukas P.
Dunham A.
Dunham I.
Durbin R.
French L.
Grafham D.
Gregory S.
Hubbard T.
Humphray S.
Hunt A.
Jones M.
Lloyd C.
McMurray A.
Matthews L.
Mercer S.
Milne S.
Mullikin J.C.
Mungall A.
Plumb R.
Ross M.
Shownkeen R.
Sims S.
Waterston R.H.
Wilson R.K.
Hillier L.W.
McPherson J.D.
Marra M.A.
Mardis E.R.
Fulton L.A.
Chinwalla A.T.
Pepin K.H.
Gish W.R.
Chissoe S.L.
Wendl M.C.
Delehaunty K.D.
Miner T.L.
Delehaunty A.
Kramer J.B.
Cook L.L.
Fulton R.S.
Johnson D.L.
Minx P.J.
Clifton S.W.
Hawkins T.
Branscomb E.
Predki P.
Richardson P.
Wenning S.
Slezak T.
Doggett N.
Cheng J.F.
Olsen A.
Lucas S.
Elkin C.
Uberbacher E.
Frazier M.
Gibbs R.A.
Muzny D.M.
Scherer S.E.
Bouck J.B.
Sodergren E.J.
Worley K.C.
Rives C.M.
Gorrell J.H.
Metzker M.L.
Naylor S.L.
Kucherlapati R.S.
Nelson D.L.
Weinstock G.M.
Sakaki Y.
Fujiyama A.
Hattori M.
Yada T.
Toyoda A.
Itoh T.
Kawagoe C.
Watanabe H.
Totoki Y.
Taylor T.
Weissenbach J.
Heilig R.
Saurin W.
Artiguenave F.
Brottier P.
Bruls T.
Pelletier E.
Robert C.
Wincker P.
Smith D.R.
Doucette-Stamm L.
Rubenfield M.
Weinstock K.
Lee H.M.
Dubois J.
Rosenthal A.
Platzer M.
Nyakatura G.
Taudien S.
Rump A.
Yang H.
Yu J.
Wang J.
Huang G.
Gu J.
Hood L.
Rowen L.
Madan A.
Qin S.
Davis R.W.
Federspiel N.A.
Abola A.P.
Proctor M.J.
Myers R.M.
Schmutz J.
Dickson M.
Grimwood J.
Cox D.R.
Olson M.V.
Kaul R.
Raymond C.
Shimizu N.
Kawasaki K.
Minoshima S.
Evans G.A.
Athanasiou M.
Schultz R.
Roe B.A.
Chen F.
Pan H.
Ramser J.
Lehrach H.
Reinhardt R.
McCombie W.R.
de la Bastide M.
Dedhia N.
Blocker H.
Hornischer K.
Nordsiek G.
Agarwala R.
Aravind L.
Bailey J.A.
Bateman A.
Batzoglou S.
Birney E.
Bork P.
Brown D.G.
Burge C.B.
Cerutti L.
Chen H.C.
Church D.
Clamp M.
Copley R.R.
Doerks T.
Eddy S.R.
Eichler E.E.
Furey T.S.
Galagan J.
Gilbert J.G.
Harmon C.
Hayashizaki Y.
Haussler D.
Hermjakob H.
Hokamp K.
Jang W.
Johnson L.S.
Jones T.A.
Kasif S.
Kaspryzk A.
Kennedy S.
Kent W.J.
Kitts P.
Koonin E.V.
Korf I.
Kulp D.
Lancet D.
Lowe T.M.
McLysaght A.
Mikkelsen T.
Moran J.V.
Mulder N.
Pollara V.J.
Ponting C.P.
Schuler G.
Schultz J.
Slater G.
Smit A.F.
Stupka E.
Szustakowski J.
Thierry-Mieg D.
Thierry-Mieg J.
Wagner L.
Wallis J.
Wheeler R.
Williams A.
Wolf Y.I.
Wolfe K.H.
Yang S.P.
Yeh R.F.
Collins F.
Guyer M.S.
Peterson J.
Felsenfeld A.
Wetterstrand K.A.
Patrinos A.
Morgan M.J.
de Jong P.
Catanese J.J.
Osoegawa K.
Shizuya H.
Choi S.
Chen Y.J.


Helical

Helical

Helical

Helical

Helical

Helical

Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).

G-PROTEIN COUPLED RECEPTOR CG31760-RELATED

Belongs to the G-protein coupled receptor 3 family


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Zygaenoidea Limacodidae Comana

Single

Goudarzi M.H.
Robinson S.D.
Cardoso F.C.
Mitchell M.L.
Cook L.G.
King G.F.
Walker A.A.

Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Peiratinae Ectomocoris

CUB

Disordered

Gly residues

Low complexity


Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Gastropoda Caenogastropoda Neogastropoda Buccinoidea Buccinidae Colubraria

VWFA

VWFA

VWFA

VWFA

Disordered

Low complexity

Modica M.V.
Gerdol M.
Fracarossi D.
Cervelli M.
Reinoso Sanchez J.F.
Leone S.
Tartaglia G.
Milanetti E.
Vassalli Q.A.
Ruggeri Z.M.
Oliverio M.

A vampire's tale: a novel family of anti-platelet proteins from the marine snail Cumia reticulata.


Importin N-terminal

Mikhailov K.
Kravchuk O.
Lyupina Y.
Adameyko K.

F:nuclear export signal receptor activity


Aspartate/ornithine carbamoyltransferase carbamoyl-P binding

Ross M.T.
Grafham D.V.
Coffey A.J.
Scherer S.
McLay K.
Muzny D.
Platzer M.
Howell G.R.
Burrows C.
Bird C.P.
Frankish A.
Lovell F.L.
Howe K.L.
Ashurst J.L.
Fulton R.S.
Sudbrak R.
Wen G.
Jones M.C.
Hurles M.E.
Andrews T.D.
Scott C.E.
Searle S.
Ramser J.
Whittaker A.
Deadman R.
Carter N.P.
Hunt S.E.
Chen R.
Cree A.
Gunaratne P.
Havlak P.
Hodgson A.
Metzker M.L.
Richards S.
Scott G.
Steffen D.
Sodergren E.
Wheeler D.A.
Worley K.C.
Ainscough R.
Ambrose K.D.
Ansari-Lari M.A.
Aradhya S.
Ashwell R.I.
Babbage A.K.
Bagguley C.L.
Ballabio A.
Banerjee R.
Barker G.E.
Barlow K.F.
Barrett I.P.
Bates K.N.
Beare D.M.
Beasley H.
Beasley O.
Beck A.
Bethel G.
Blechschmidt K.
Brady N.
Bray-Allen S.
Bridgeman A.M.
Brown A.J.
Brown M.J.
Bonnin D.
Bruford E.A.
Buhay C.
Burch P.
Burford D.
Burgess J.
Burrill W.
Burton J.
Bye J.M.
Carder C.
Carrel L.
Chako J.
Chapman J.C.
Chavez D.
Chen E.
Chen G.
Chen Y.
Chen Z.
Chinault C.
Ciccodicola A.
Clark S.Y.
Clarke G.
Clee C.M.
Clegg S.
Clerc-Blankenburg K.
Clifford K.
Cobley V.
Cole C.G.
Conquer J.S.
Corby N.
Connor R.E.
David R.
Davies J.
Davis C.
Davis J.
Delgado O.
Deshazo D.
Dhami P.
Ding Y.
Dinh H.
Dodsworth S.
Draper H.
Dugan-Rocha S.
Dunham A.
Dunn M.
Durbin K.J.
Dutta I.
Eades T.
Ellwood M.
Emery-Cohen A.
Errington H.
Evans K.L.
Faulkner L.
Francis F.
Frankland J.
Fraser A.E.
Galgoczy P.
Gilbert J.
Gill R.
Glockner G.
Gregory S.G.
Gribble S.
Griffiths C.
Grocock R.
Gu Y.
Gwilliam R.
Hamilton C.
Hart E.A.
Hawes A.
Heath P.D.
Heitmann K.
Hennig S.
Hernandez J.
Hinzmann B.
Ho S.
Hoffs M.
Howden P.J.
Huckle E.J.
Hume J.
Hunt P.J.
Hunt A.R.
Isherwood J.
Jacob L.
Johnson D.
Jones S.
de Jong P.J.
Joseph S.S.
Keenan S.
Kelly S.
Kershaw J.K.
Khan Z.
Kioschis P.
Klages S.
Knights A.J.
Kosiura A.
Kovar-Smith C.
Laird G.K.
Langford C.
Lawlor S.
Leversha M.
Lewis L.
Liu W.
Lloyd C.
Lloyd D.M.
Loulseged H.
Loveland J.E.
Lovell J.D.
Lozado R.
Lu J.
Lyne R.
Ma J.
Maheshwari M.
Matthews L.H.
McDowall J.
McLaren S.
McMurray A.
Meidl P.
Meitinger T.
Milne S.
Miner G.
Mistry S.L.
Morgan M.
Morris S.
Muller I.
Mullikin J.C.
Nguyen N.
Nordsiek G.
Nyakatura G.
O'Dell C.N.
Okwuonu G.
Palmer S.
Pandian R.
Parker D.
Parrish J.
Pasternak S.
Patel D.
Pearce A.V.
Pearson D.M.
Pelan S.E.
Perez L.
Porter K.M.
Ramsey Y.
Reichwald K.
Rhodes S.
Ridler K.A.
Schlessinger D.
Schueler M.G.
Sehra H.K.
Shaw-Smith C.
Shen H.
Sheridan E.M.
Shownkeen R.
Skuce C.D.
Smith M.L.
Sotheran E.C.
Steingruber H.E.
Steward C.A.
Storey R.
Swann R.M.
Swarbreck D.
Tabor P.E.
Taudien S.
Taylor T.
Teague B.
Thomas K.
Thorpe A.
Timms K.
Tracey A.
Trevanion S.
Tromans A.C.
d'Urso M.
Verduzco D.
Villasana D.
Waldron L.
Wall M.
Wang Q.
Warren J.
Warry G.L.
Wei X.
West A.
Whitehead S.L.
Whiteley M.N.
Wilkinson J.E.
Willey D.L.
Williams G.
Williams L.
Williamson A.
Williamson H.
Wilming L.
Woodmansey R.L.
Wray P.W.
Yen J.
Zhang J.
Zhou J.
Zoghbi H.
Zorilla S.
Buck D.
Reinhardt R.
Poustka A.
Rosenthal A.
Lehrach H.
Meindl A.
Minx P.J.
Hillier L.W.
Willard H.F.
Wilson R.K.
Waterston R.H.
Rice C.M.
Vaudin M.
Coulson A.
Nelson D.L.
Weinstock G.
Sulston J.E.
Durbin R.
Hubbard T.
Gibbs R.A.
Beck S.
Rogers J.
Bentley D.R.

The DNA sequence of the human X chromosome.

F:carboxyl- or carbamoyltransferase activity

Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Sternorrhyncha Coccoidea Pseudococcidae Maconellicoccus

Helical

axial binding residue

Selvamani S.B.
Negi N.
Nagarjuna Reddy K.V.
Ramasamy G.G.

Identification of Cytochrome P450s in Maconellicoccus hirsutus.

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Disordered

axial binding residue

Haem peroxidase domain superfamily, animal type


Disordered

Acidic residues

Gregory S.G.
Barlow K.F.
McLay K.E.
Kaul R.
Swarbreck D.
Dunham A.
Scott C.E.
Howe K.L.
Woodfine K.
Spencer C.C.
Jones M.C.
Gillson C.
Searle S.
Zhou Y.
Kokocinski F.
McDonald L.
Evans R.
Phillips K.
Atkinson A.
Cooper R.
Jones C.
Hall R.E.
Andrews T.D.
Lloyd C.
Ainscough R.
Almeida J.P.
Ambrose K.D.
Anderson F.
Andrew R.W.
Ashwell R.I.
Aubin K.
Babbage A.K.
Bagguley C.L.
Bailey J.
Beasley H.
Bethel G.
Bird C.P.
Bray-Allen S.
Brown J.Y.
Brown A.J.
Buckley D.
Burton J.
Bye J.
Carder C.
Chapman J.C.
Clark S.Y.
Clarke G.
Clee C.
Cobley V.
Collier R.E.
Corby N.
Coville G.J.
Davies J.
Deadman R.
Dunn M.
Earthrowl M.
Ellington A.G.
Errington H.
Frankish A.
Frankland J.
French L.
Garner P.
Garnett J.
Gay L.
Ghori M.R.
Gibson R.
Gilby L.M.
Gillett W.
Glithero R.J.
Grafham D.V.
Griffiths C.
Griffiths-Jones S.
Grocock R.
Hammond S.
Harrison E.S.
Hart E.
Haugen E.
Heath P.D.
Holmes S.
Holt K.
Howden P.J.
Hunt A.R.
Hunt S.E.
Hunter G.
Isherwood J.
James R.
Johnson C.
Johnson D.
Joy A.
Kay M.
Kershaw J.K.
Kibukawa M.
Kimberley A.M.
King A.
Knights A.J.
Lad H.
Laird G.
Lawlor S.
Leongamornlert D.A.
Lloyd D.M.
Loveland J.
Lovell J.
Lush M.J.
Lyne R.
Martin S.
Mashreghi-Mohammadi M.
Matthews L.
Matthews N.S.
McLaren S.
Milne S.
Mistry S.
Moore M.J.
Nickerson T.
O'Dell C.N.
Oliver K.
Palmeiri A.
Palmer S.A.
Parker A.
Patel D.
Pearce A.V.
Peck A.I.
Pelan S.
Phelps K.
Phillimore B.J.
Plumb R.
Rajan J.
Raymond C.
Rouse G.
Saenphimmachak C.
Sehra H.K.
Sheridan E.
Shownkeen R.
Sims S.
Skuce C.D.
Smith M.
Steward C.
Subramanian S.
Sycamore N.
Tracey A.
Tromans A.
Van Helmond Z.
Wall M.
Wallis J.M.
White S.
Whitehead S.L.
Wilkinson J.E.
Willey D.L.
Williams H.
Wilming L.
Wray P.W.
Wu Z.
Coulson A.
Vaudin M.
Sulston J.E.
Durbin R.
Hubbard T.
Wooster R.
Dunham I.
Carter N.P.
McVean G.
Ross M.T.
Harrow J.
Olson M.V.
Beck S.
Rogers J.
Bentley D.R.
Banerjee R.
Bryant S.P.
Burford D.C.
Burrill W.D.
Clegg S.M.
Dhami P.
Dovey O.
Faulkner L.M.
Gribble S.M.
Langford C.F.
Pandian R.D.
Porter K.M.
Prigmore E.

The DNA sequence and biological annotation of human chromosome 1.


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Clitellata Hirudinea Hirudinida Hirudiniformes Hirudinidae Hirudo

F5/8 type C domain-containing protein


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Polypodiopsida Polypodiidae Polypodiales Polypodiineae Polypodiaceae Microsoroideae Leptochilus

Wei J.Z.
Lum A.
Schepers E.
Liu L.
Weston R.T.
McGinness B.S.
Heckert M.J.
Xie W.
Kassa A.
Bruck D.
Rauscher G.
Kapka-Kitzman D.
Mathis J.P.
Zhao J.Z.
Sethi A.
Barry J.
Lu A.L.
Brugliera F.
Lee E.L.
van derWeerden N.L.
Eswar N.
Maher M.J.
Anderson M.A.

Novel insecticidal proteins from ferns resemble insecticidal proteins from <i>Bacillus thuringiensis</i>.

X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS)
DISULFIDE BONDS

Pesticidal crystal protein, N-terminal domain

delta-Endotoxin (insectocide), N-terminal domain


VWFA

Disordered

Pro residues


Eukaryota Metazoa Spiralia Lophotrochozoa Brachiopoda Rhynchonelliformea Rhynchonellata Terebratellidina Laqueoidea Laqueidae Laqueus

PAS

Disordered

Belato F.A.
Mello B.
Coates C.J.
Halanych K.M.
Brown F.D.
Morandini A.C.
Leme J.M.
Trindade R.I.F.
Costa-Paiva E.M.

Divergence time estimates for the hypoxia-inducible factor-1 alpha (HIF1a) reveal an ancient emergence of animals in low-oxygen environments.

F:RNA polymerase II transcription regulatory region sequence-specific DNA binding

Hypoxia-inducible factor 1-alpha isoform 1


Eukaryota Metazoa Cnidaria Scyphozoa Semaeostomeae Ulmaridae Aurelia

TGF-beta propeptide

Disordered

Basic and acidic residues

Basic residues

Tetraradial symmetry disturbance and recovery at feeding-dependent tentacle initiations in Aurelia aurita polyps.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Pentatomomorpha Pyrrhocoroidea Pyrrhocoridae Pyrrhocoris


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Hymenoptera Apocrita Aculeata Formicoidea Formicidae Myrmicinae Pogonomyrmex

Valine amide

Robinson S.D.
Deuis J.R.
Niu P.
Touchard A.
Mueller A.
Schendel V.
Brinkwirth N.
King G.F.
Vetter I.
Schmidt J.O.

Peptide toxins that target vertebrate voltage-gated sodium channels underly the painful stings of harvester ants.

NUCLEOTIDE SEQUENCE [MRNA]
IDENTIFICATION BY MASS SPECTROMETRY
SUBCELLULAR LOCATION
SYNTHESIS OF 38-66
BIOASSAY
TOXIC DOSE
AMIDATION AT VAL-66

Toxin that causes a rapid and irreversible paralysis when intrathoracically injected into insects (blowflies). Does not cause spontaneous nocifensive behaviors by intraplantar injection in mice. Exhibits hemolytic and cytotoxic activities on HEK293 cells

PD(50) [1 hour] is 9.9 nmol/g when intrathoracically injected into insects (blowfly L.caesar)

Belongs to the formicidae venom clade 3 family


Helical


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Stenopodainae Oncocephalus

Zdenek C.N.
Cardoso F.C.
Robinson S.D.
Mercedes R.S.
Raidjoe E.R.
Hernandez-Vargas M.J.
Jin J.
Corzo G.
Vetter I.
King G.F.
Fry B.G.
Walker A.

Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Acari Acariformes Trombidiformes Prostigmata Eleutherengona Heterostigmata Tarsonemoidea Tarsonemidae Polyphagotarsonemus

Helical

Helical

Helical

F:transmitter-gated monoatomic ion channel activity

P:cell surface receptor signaling pathway

Glutamate receptor ionotropic, kainate 2

Putative glutamate receptor ionotropic kainate 1

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Tineoidea Gracillariidae Conopomorpha

Helical

Helical

Helical

Helical

Helical

Helical

Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family

Lacks conserved residue(s) required for the propagation of feature annotation


Helical

Helical

Helical

Helical

F:acetylcholine-gated monoatomic cation-selective channel activity

F:transmembrane signaling receptor activity

Neurotransmitter-gated ion-channel ligand-binding domain

Neurotransmitter-gated ion-channel transmembrane domain

Neurotransmitter-gated ion-channel transmembrane pore

Nicotinic receptor ligand binding domain-like

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily


Eukaryota Metazoa Spiralia Lophotrochozoa Platyhelminthes Rhabditophora Seriata Tricladida Continenticola Geoplanoidea Dugesiidae Dugesia

Fibronectin type-II

Identification of a GLIPR1-like gene in planarian Dugesia japonica.


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Polychaeta Sedentaria Canalipalpata Terebellida Terebelliformia Alvinellidae Alvinella

RecA family profile 1

Longo M.A.
Roy S.
Chen Y.
Tomaszowski K.H.
Arvai A.S.
Pepper J.T.
Boisvert R.A.
Kunnimalaiyaan S.
Keshvani C.
Schild D.
Bacolla A.
Williams G.J.
Tainer J.A.
Schlacher K.

RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles.

X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) IN COMPLEX WITH ADP

F:ATP-dependent DNA damage sensor activity

P:double-strand break repair via synthesis-dependent strand annealing

P:resolution of mitotic recombination intermediates

P:telomere maintenance via recombination

P-loop containing nucleotide triphosphate hydrolases

P-loop containing nucleoside triphosphate hydrolases


Eukaryota Fungi Dikarya Ascomycota Pezizomycotina Sordariomycetes Xylariomycetidae Amphisphaeriales Apiosporaceae Apiospora

Arginine-containing cyclodipeptide synthase amaA

Conserved DDXXE motif

Yee D.A.
Niwa K.
Perlatti B.
Chen M.
Li Y.
Tang Y.

Genome mining for unknown-unknown natural products.

Arginine-containing cyclodipeptide synthase; part of the cluster that mediates the biosynthesis of a highly modified cyclo-arginine-proline dipeptide (cRP) (PubMed:36702957). Within the pathway, amaA acts as the scaffold-generating enzyme and is responsible for formation of the cyclo-Arg-Pro diketopiperazine (cRW) from L-arginyl-tRNA(Arg) + L-prolyl-tRNA(Pro) (PubMed:36702957). Additional enzymes from the cluster then further modify the cyclo-Arg-Pro diketopiperazine (cRW) scaffold (Probable)

L-prolyl-tRNA(Pro) + L-arginyl-tRNA(Arg) = cyclo(L-arginyl-L-prolyl) + tRNA(Pro) + tRNA(Arg) + 2 H(+)

The conserved DDXXE motif is essential for catalytic activity

Belongs to the arginine-containing cyclodipeptide synthase family


Eukaryota Metazoa Porifera Demospongiae Verongimorpha Chondrillida Halisarcidae Halisarca

IF rod

LTD

Disordered

Intermediate filament protein, coiled coil region


Eukaryota Sar Stramenopiles Bigyra Labyrinthulomycetes Thraustochytrida Thraustochytriidae Schizochytrium

Helical

Helical

Helical

Helical

Helical

Helical

Metabolism balance regulation for squalene production by disturbing triglycerides (TAG) synthesis in Schizochytrium sp.

P:fatty acid elongation, monounsaturated fatty acid

P:fatty acid elongation, polyunsaturated fatty acid

P:fatty acid elongation, saturated fatty acid

P:very long-chain fatty acid biosynthetic process

an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA


Helical

axial binding residue

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


VWFA

VWFA

VWFA

VWFA

VWFA

VWFA

VWFA


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Amphibia Batrachia Anura Neobatrachia Ranoidea Ranidae Nidirana

Zheng P.
Gong Y.
Wang B.
Yu H.
Huang S.
Liao X.
Jiang J.
Ran J.
Xie F.

Love Hug-Functional Validation of Nuptial Pad-Secreted Pheromone in Anurans.


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae asterids lamiids Gentianales Apocynaceae Asclepiadoideae Marsdenieae Gymnema

RIN4 pathogenic type III effector avirulence factor Avr cleavage site

Disordered

Disordered

Polar residues

Transcriptomic revealing of plant pathogen interaction in Gymnema sylvestre.

RPM1-INTERACTING PROTEIN 4 (RIN4) FAMILY PROTEIN


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo

Initial sequencing and analysis of the human genome.

Mungall A.J.
Palmer S.A.
Sims S.K.
Edwards C.A.
Ashurst J.L.
Wilming L.
Jones M.C.
Horton R.
Hunt S.E.
Scott C.E.
Gilbert J.G.
Clamp M.E.
Bethel G.
Milne S.
Ainscough R.
Almeida J.P.
Ambrose K.D.
Andrews T.D.
Ashwell R.I.
Babbage A.K.
Bagguley C.L.
Bailey J.
Banerjee R.
Barker D.J.
Barlow K.F.
Bates K.
Beare D.M.
Beasley H.
Beasley O.
Bird C.P.
Blakey S.
Bray-Allen S.
Brook J.
Brown A.J.
Brown J.Y.
Burford D.C.
Burrill W.
Burton J.
Carder C.
Carter N.P.
Chapman J.C.
Clark S.Y.
Clark G.
Clee C.M.
Clegg S.
Cobley V.
Collier R.E.
Collins J.E.
Colman L.K.
Corby N.R.
Coville G.J.
Culley K.M.
Dhami P.
Davies J.
Dunn M.
Earthrowl M.E.
Ellington A.E.
Evans K.A.
Faulkner L.
Francis M.D.
Frankish A.
Frankland J.
French L.
Garner P.
Garnett J.
Ghori M.J.
Gilby L.M.
Gillson C.J.
Glithero R.J.
Grafham D.V.
Grant M.
Gribble S.
Griffiths C.
Griffiths M.
Hall R.
Halls K.S.
Hammond S.
Harley J.L.
Hart E.A.
Heath P.D.
Heathcott R.
Holmes S.J.
Howden P.J.
Howe K.L.
Howell G.R.
Huckle E.
Humphray S.J.
Humphries M.D.
Hunt A.R.
Johnson C.M.
Joy A.A.
Kay M.
Keenan S.J.
Kimberley A.M.
King A.
Laird G.K.
Langford C.
Lawlor S.
Leongamornlert D.A.
Leversha M.
Lloyd C.R.
Lloyd D.M.
Loveland J.E.
Lovell J.
Martin S.
Mashreghi-Mohammadi M.
Maslen G.L.
Matthews L.
McCann O.T.
McLaren S.J.
McLay K.
McMurray A.
Moore M.J.
Mullikin J.C.
Niblett D.
Nickerson T.
Novik K.L.
Oliver K.
Overton-Larty E.K.
Parker A.
Patel R.
Pearce A.V.
Peck A.I.
Phillimore B.
Phillips S.
Plumb R.W.
Porter K.M.
Ramsey Y.
Ranby S.A.
Rice C.M.
Ross M.T.
Searle S.M.
Sehra H.K.
Sheridan E.
Skuce C.D.
Smith S.
Smith M.
Spraggon L.
Squares S.L.
Steward C.A.
Sycamore N.
Tamlyn-Hall G.
Tester J.
Theaker A.J.
Thomas D.W.
Thorpe A.
Tracey A.
Tromans A.
Tubby B.
Wall M.
Wallis J.M.
West A.P.
White S.S.
Whitehead S.L.
Whittaker H.
Wild A.
Willey D.J.
Wilmer T.E.
Wood J.M.
Wray P.W.
Wyatt J.C.
Young L.
Younger R.M.
Bentley D.R.
Coulson A.
Durbin R.
Hubbard T.
Sulston J.E.
Dunham I.
Rogers J.
Beck S.

The DNA sequence and analysis of human chromosome 6.

Finishing the euchromatic sequence of the human genome.

P:intermediate filament cytoskeleton organization

Belongs to the plakin or cytolinker family


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Coleoptera Polyphaga Cucujiformia Curculionidae Scolytinae Ips

Helical

Helical

Helical

Helical

Helical

Helical

Biswas T.
Sims C.
Yuvaraj J.K.
Roberts R.E.
Lofstedt C.
Andersson M.N.

Functional characterization supports multiple evolutionary origins of pheromone receptors bark beetles.

Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family

Lacks conserved residue(s) required for the propagation of feature annotation


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Sternorrhyncha Coccoidea Pseudococcidae Maconellicoccus

Identification of Cytochrome P450s in Maconellicoccus hirsutus.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Coleoptera Polyphaga Cucujiformia Curculionidae Curculioninae Anthonomini Anthonomus

Disordered

Segura Leon O.L.
Lechuga-Paredes P.
Cibrian Tovar J.
Torres Huerta B.

Lechuga-Paredes P.
Segura-Leon O.L.
Cibrian-Tovar J.
Torres-Huerta B.
Velazquez-Gonzalez J.C.
Cruz-Jaramillo J.L.

Odorant-Binding and Chemosensory Proteins in Anthonomus eugenii (Coleoptera: Curculionidae) and Their Tissue Expression.

Pheromone/general odorant binding protein domain


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae asterids lamiids Gentianales Loganiaceae Strychnos

Diaboline synthase

Proton acceptor

Proton acceptor

Hong B.
Grzech D.
Caputi L.
Sonawane P.
Lopez C.E.R.
Kamileen M.O.
Hernandez Lozada N.J.
Grabe V.
O'Connor S.E.

Biosynthesis of strychnine.

NUCLEOTIDE SEQUENCE [MRNA]
FUNCTION
CATALYTIC ACTIVITY
PATHWAY
SUBCELLULAR LOCATION

Acetyltransferase involved in the biosynthesis of curare monoterpene indole alkaloids (MIAs), natural products such as diaboline, a pharmacologically active compound used to regulate blood pressure (PubMed:35794473). Curare alkaloids act as animal glycine receptor antagonists (PubMed:35794473). Catalyzes the conversion of 17,18-epoxy-17-hydroxycur-19-ene (Wieland-Gumlich aldehyde) to diaboline (PubMed:35794473)

17,18-epoxy-17-hydroxycur-19-ene + acetyl-CoA = diaboline + CoA

Belongs to the plant acyltransferase family


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Megaloptera Corydalidae Corydalinae Protohermes

Helical

Helical

Helical

Helical

Farnesoic acid O-methyl transferase

Yang J.
Wen X.
Zou J.
Huang X.
Wu T.
Huang X.

De novo transcriptome analysis of Protohermes xanthodes Navas (Megaloptera: Corydalidae) reveling the effects of sublethal chlorpyrifos on the expression of cholinergic neuronal genes.

F:extracellular ligand-gated monoatomic ion channel activity

Neurotransmitter-gated ion-channel ligand-binding domain

Neurotransmitter-gated ion-channel transmembrane domain

Neurotransmitter-gated ion-channel transmembrane pore

Nicotinic receptor ligand binding domain-like


Helical

Helical

Helical

Disordered

Disordered

Polar residues

Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).

F:ligand-gated monoatomic ion channel activity

glutamate receptor ionotropic, NMDA 1 isoform X1

Putative glutamate receptor ionotropic NMDA 2B

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family


Gamma-aminobutyric acid receptor subunit beta

Helical

Helical

Helical

Helical

Disordered

Low complexity

F:ligand-gated monoatomic anion channel activity

F:transmembrane signaling receptor activity

Gamma-aminobutyric acid receptor isoform 3b

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily


Fibrinogen C-terminal


Metabotropic glutamate receptor-like protein

Helical

Helical

Helical

Helical

Helical

Helical

Helical

G-protein coupled receptors family 3 profile


Eukaryota
Viridiplantae
Streptophyta
Embryophyta
Tracheophyta
Spermatophyta
Pinopsida
Pinidae
Conifers I
Pinales
Pinaceae
Pinus
Pinus subgen. Pinus

Helicase C-terminal

Dicer dsRNA-binding fold

PAZ

RNase III

RNase III

DRBM

DRBM

Disordered

Polar residues

Identification of RNAi-Related Genes and Transcriptome Assembly of Loblolly Pine (Pinus taeda, L.) Seedlings Exposed to Insect-Specific dsRNA.

P-loop containing nucleotide triphosphate hydrolases

P-loop containing nucleoside triphosphate hydrolases

Belongs to the helicase family. Dicer subfamily


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae rosids fabids Fabales Fabaceae Detarioideae Saraceae Saraca

Transcriptome analysis of Saraca asoca.

F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Stenopodainae Oncocephalus


Eukaryota
Viridiplantae
Streptophyta
Embryophyta
Tracheophyta
Spermatophyta
Magnoliopsida
eudicotyledons
Gunneridae
Pentapetalae
rosids
fabids
Fabales
Fabaceae
Papilionoideae
50 kb inversion clade
NPAAA clade
indigoferoid/millettioid clade
Millettieae
Pongamia

Mature leaf cDNA fragments from Pongamia pinnata.


Bacteria Bacillati Cyanobacteriota Cyanophyceae Gloeobacterales Anthocerotibacteraceae Anthocerotibacter

PBS-linker

PBS-linker

Jiang H.W.
Wu H.Y.
Wang C.H.
Yang C.H.
Ko J.T.
Ho H.C.
Tsai M.D.
Bryant D.A.
Li F.W.
Ho M.C.
Ho M.Y.

A structure of the relict phycobilisome from a thylakoid-free cyanobacterium.

STRUCTURE BY ELECTRON MICROSCOPY (2.74 ANGSTROMS)

C:plasma membrane-derived thylakoid membrane

PHYCOBILISOME 32.1 KDA LINKER POLYPEPTIDE, PHYCOCYANIN-ASSOCIATED, ROD 2-RELATED

Belongs to the phycobilisome linker protein family


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Bovinae Bos

Metallo-beta-lactamase

Disordered

Basic and acidic residues

Rosen B.D.
Bickhart D.M.
Koren S.
Schnabel R.D.
Hall R.
Zimin A.
Dreischer C.
Schultheiss S.
Schroeder S.G.
Elsik C.G.
Couldrey C.
Liu G.E.
Van Tassell C.P.
Phillippy A.M.
Smith T.P.L.
Medrano J.F.

ARS-UCD1.2.

PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Peracarida Isopoda Oniscidea Crinocheta Paraplatyarthridae Paraplatyarthrus

cellulose 1,4-beta-cellobiosidase (non-reducing end)

Javidkar M.
Cooper S.J.B.
Shokri Bousjein N.
Humphreys W.F.
King R.A.
Austin A.D.

Evolution of endoglucanase genes in subterranean and surface isopod crustaceans from Central Western Australia.

F:hydrolase activity, hydrolyzing O-glycosyl compounds

Hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.

Belongs to the glycosyl hydrolase 7 (cellulase C) family


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Auchenorrhyncha Membracoidea Cicadellidae Typhlocybinae Empoascini Empoasca

Disordered

Disordered

Low complexity

Low complexity

Low complexity

Low complexity

Low complexity

Low complexity

Low complexity

Low complexity

Low complexity

Low complexity

Low complexity


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Leucinodes

Helical

Helical

Helical

Pathak J.
Thiruvengadam V.
Gracy G.R.
M M.


Eukaryota Metazoa Spiralia Lophotrochozoa Brachiopoda Rhynchonelliformea Rhynchonellata Terebratellidina Laqueoidea Laqueidae Terebratalia

Helical

Vellutini B.C.
Martin-Duran J.M.
Borve A.
Hejnol A.

Combinatorial Wnt signaling landscape during brachiopod anteroposterior patterning.

Ligand for members of the frizzled family of seven transmembrane receptors

Secreted, extracellular space, extracellular matrix


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Neopterygii Teleostei Ostariophysi Cypriniformes Danionidae Danioninae Danio

Phospholipase/carboxylesterase/thioesterase

Howe K.
Clark M.D.
Torroja C.F.
Torrance J.
Berthelot C.
Muffato M.
Collins J.E.
Humphray S.
McLaren K.
Matthews L.
McLaren S.
Sealy I.
Caccamo M.
Churcher C.
Scott C.
Barrett J.C.
Koch R.
Rauch G.J.
White S.
Chow W.
Kilian B.
Quintais L.T.
Guerra-Assuncao J.A.
Zhou Y.
Gu Y.
Yen J.
Vogel J.H.
Eyre T.
Redmond S.
Banerjee R.
Chi J.
Fu B.
Langley E.
Maguire S.F.
Laird G.K.
Lloyd D.
Kenyon E.
Donaldson S.
Sehra H.
Almeida-King J.
Loveland J.
Trevanion S.
Jones M.
Quail M.
Willey D.
Hunt A.
Burton J.
Sims S.
McLay K.
Plumb B.
Davis J.
Clee C.
Oliver K.
Clark R.
Riddle C.
Elliot D.
Eliott D.
Threadgold G.
Harden G.
Ware D.
Begum S.
Mortimore B.
Mortimer B.
Kerry G.
Heath P.
Phillimore B.
Tracey A.
Corby N.
Dunn M.
Johnson C.
Wood J.
Clark S.
Pelan S.
Griffiths G.
Smith M.
Glithero R.
Howden P.
Barker N.
Lloyd C.
Stevens C.
Harley J.
Holt K.
Panagiotidis G.
Lovell J.
Beasley H.
Henderson C.
Gordon D.
Auger K.
Wright D.
Collins J.
Raisen C.
Dyer L.
Leung K.
Robertson L.
Ambridge K.
Leongamornlert D.
McGuire S.
Gilderthorp R.
Griffiths C.
Manthravadi D.
Nichol S.
Barker G.
Whitehead S.
Kay M.
Brown J.
Murnane C.
Gray E.
Humphries M.
Sycamore N.
Barker D.
Saunders D.
Wallis J.
Babbage A.
Hammond S.
Mashreghi-Mohammadi M.
Barr L.
Martin S.
Wray P.
Ellington A.
Matthews N.
Ellwood M.
Woodmansey R.
Clark G.
Cooper J.
Cooper J.
Tromans A.
Grafham D.
Skuce C.
Pandian R.
Andrews R.
Harrison E.
Kimberley A.
Garnett J.
Fosker N.
Hall R.
Garner P.
Kelly D.
Bird C.
Palmer S.
Gehring I.
Berger A.
Dooley C.M.
Ersan-Urun Z.
Eser C.
Geiger H.
Geisler M.
Karotki L.
Kirn A.
Konantz J.
Konantz M.
Oberlander M.
Rudolph-Geiger S.
Teucke M.
Lanz C.
Raddatz G.
Osoegawa K.
Zhu B.
Rapp A.
Widaa S.
Langford C.
Yang F.
Schuster S.C.
Carter N.P.
Harrow J.
Ning Z.
Herrero J.
Searle S.M.
Enright A.
Geisler R.
Plasterk R.H.
Lee C.
Westerfield M.
de Jong P.J.
Zon L.I.
Postlethwait J.H.
Nusslein-Volhard C.
Hubbard T.J.
Roest Crollius H.
Rogers J.
Stemple D.L.

The zebrafish reference genome sequence and its relationship to the human genome.

Belongs to the AB hydrolase superfamily. AB hydrolase 2 family


axial binding residue

Selvamani S.B.
Negi N.
Nagarjuna Reddy K.V.
Ramasamy G.G.

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Eukaryota Metazoa Cnidaria Scyphozoa Semaeostomeae Ulmaridae Aurelia

Helical

Protein kinase

Proton acceptor

Tetraradial symmetry disturbance and recovery at feeding-dependent tentacle initiations in Aurelia aurita polyps.

F:transmembrane receptor protein tyrosine kinase activity

P:cell surface receptor protein tyrosine kinase signaling pathway

FIBROBLAST GROWTH FACTOR RECEPTOR HOMOLOG 1-RELATED


Helical

Helical


Disordered

Polar residues

Low complexity

Polar residues

Basic and acidic residues

Basic and acidic residues

Basic and acidic residues

Zdenek C.N.
Cardoso F.C.
Robinson S.D.
Mercedes R.S.
Raidjoe E.R.
Hernandez-Vargas M.J.
Jin J.
Corzo G.
Vetter I.
King G.F.
Fry B.G.
Walker A.

Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Peracarida Isopoda Oniscidea Crinocheta Porcellionidae Porcellionides

cellulase

Glycoside hydrolase family 9

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Belongs to the glycosyl hydrolase 9 (cellulase E) family


Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Cephalopoda Coleoidea Octopodiformes Octopoda Incirrata Octopodidae Callistoctopus

Disordered

Basic and acidic residues

Type I PLP-dependent aspartate aminotransferase-like (Major domain)

GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE

Belongs to the group II decarboxylase family


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Acari Acariformes Trombidiformes Prostigmata Eleutherengona Heterostigmata Tarsonemoidea Tarsonemidae Polyphagotarsonemus

Belongs to the UDP-glycosyltransferase family


Protein Wnt


Helical

Helical

Helical

Helical

Helical

Helical

Helical

Rhodopsin 7-helix transmembrane proteins

Family A G protein-coupled receptor-like

Belongs to the G-protein coupled receptor 1 family


Cystatin

F:cysteine-type endopeptidase inhibitor activity


Helical

Helical

Helical

Helical

Helical

Helical

Helical