Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo

Disordered


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Sternorrhyncha Coccoidea Pseudococcidae Maconellicoccus

Helical

axial binding residue

Selvamani S.B.
Negi N.
Nagarjuna Reddy K.V.
Ramasamy G.G.

Identification of Cytochrome P450s in Maconellicoccus hirsutus.

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Gastropoda Caenogastropoda Neogastropoda Buccinoidea Buccinidae Colubraria

VWFA

Disordered

Basic residues

Basic residues

Modica M.V.
Gerdol M.
Fracarossi D.
Cervelli M.
Reinoso Sanchez J.F.
Leone S.
Tartaglia G.
Milanetti E.
Vassalli Q.A.
Ruggeri Z.M.
Oliverio M.

A vampire's tale: a novel family of anti-platelet proteins from the marine snail Cumia reticulata.


Eukaryota Metazoa Porifera Demospongiae Verongimorpha Chondrillida Halisarcidae Halisarca


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Leucinodes

Pathak J.
Thiruvengadam V.
Gracy G.R.
M M.

Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Bovinae Bos

Rosen B.D.
Bickhart D.M.
Koren S.
Schnabel R.D.
Hall R.
Zimin A.
Dreischer C.
Schultheiss S.
Schroeder S.G.
Elsik C.G.
Couldrey C.
Liu G.E.
Van Tassell C.P.
Phillippy A.M.
Smith T.P.L.
Medrano J.F.

ARS-UCD1.2.

NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]


Eukaryota Sar Stramenopiles Oomycota Peronosporales Peronosporaceae Phytophthora

Structure of RxLR121 effector from phytophthora capsici.


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Pleocyemata Brachyura Eubrachyura Potamoidea Potamidae Aparapotamon

Shi B.Y.
Pan D.
Zhang K.Q.
Gu T.Y.
Yeo D.C.J.
Ng P.K.L.
Cumberlidge N.
Sun H.Y.

Diversification of freshwater crabs on the sky islands in the Hengduan Mountains Region, China.

P:chondroitin sulfate proteoglycan biosynthetic process

3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O = 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + phosphate

Belongs to the histidine acid phosphatase family


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Stenopodainae Oncocephalus

Zdenek C.N.
Cardoso F.C.
Robinson S.D.
Mercedes R.S.
Raidjoe E.R.
Hernandez-Vargas M.J.
Jin J.
Corzo G.
Vetter I.
King G.F.
Fry B.G.
Walker A.

Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Pleocyemata Brachyura Eubrachyura Potamoidea Potamidae Tenuipotamon

Helical

Helical

Disordered

Basic and acidic residues

Polar residues

Rhodopsin 7-helix transmembrane proteins

G-PROTEIN COUPLED RECEPTOR B0563.6-LIKE PROTEIN-RELATED

G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN

Family A G protein-coupled receptor-like


Helical

Helical


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Polychaeta Sedentaria Canalipalpata Sabellida Siboglinidae Ridgeia

Ig-like

Perez M.
Aroh O.
Sun Y.
Lan Y.
Juniper S.K.
Young C.R.
Angers B.
Qian P.Y.

Third-Generation Sequencing Reveals the Adaptive Role of the Epigenome in Three Deep-Sea Polychaetes.

CARTILAGE INTERMEDIATE LAYER PROTEIN 1-LIKE ISOFORM X1

CARTILAGE INTERMEDIATE LAYER PROTEIN CLIP

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data


Helical

Helical

Helical

Helical


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Pleocyemata Brachyura Eubrachyura Potamoidea Potamidae Lobothelphusa

Peptidyl-prolyl cis-trans isomerase FKBP62-like protein


Helical


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae Saxifragales Paeoniaceae Paeonia

Helical

Disordered

Basic and acidic residues

Low complexity


Eukaryota
Viridiplantae
Streptophyta
Embryophyta
Tracheophyta
Spermatophyta
Magnoliopsida
Liliopsida
Poales
Poaceae
BOP clade
Pooideae
Triticodae
Triticeae
Triticinae
Aegilops

Mixed lineage kinase-like domain-containing kinase

Protein kinase

Disordered

Polar residues

MLKL-K, a mixed lineage kinase-like domain-containing kinase gene, originated from Aegilops longissima confers resistance to wheat powdery mildew.

F:protein serine/threonine kinase activity

P:cell surface receptor signaling pathway

C2 CALCIUM/LIPID-BINDING PLANT PHOSPHORIBOSYLTRANSFERASE FAMILY PROTEIN

PROTEIN KINASE DOMAIN-CONTAINING PROTEIN

Belongs to the protein kinase superfamily


S S.B.
Negi N.
Nagarjuna Reddy K.
R G.G.

Takout-proteins of Maconellicoccus hirsutus.

Haemolymph juvenile hormone binding protein

CIRCADIAN CLOCK-CONTROLLED PROTEIN-LIKE PROTEIN


Helical

axial binding residue

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides


SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative)

Helical

Helical

Helical

Helical

Major facilitator superfamily (MFS) profile

Disordered

International Human Genome Sequencing Consortium

Lander E.S.
Linton L.M.
Birren B.
Nusbaum C.
Zody M.C.
Baldwin J.
Devon K.
Dewar K.
Doyle M.
FitzHugh W.
Funke R.
Gage D.
Harris K.
Heaford A.
Howland J.
Kann L.
Lehoczky J.
LeVine R.
McEwan P.
McKernan K.
Meldrim J.
Mesirov J.P.
Miranda C.
Morris W.
Naylor J.
Raymond C.
Rosetti M.
Santos R.
Sheridan A.
Sougnez C.
Stange-Thomann N.
Stojanovic N.
Subramanian A.
Wyman D.
Rogers J.
Sulston J.
Ainscough R.
Beck S.
Bentley D.
Burton J.
Clee C.
Carter N.
Coulson A.
Deadman R.
Deloukas P.
Dunham A.
Dunham I.
Durbin R.
French L.
Grafham D.
Gregory S.
Hubbard T.
Humphray S.
Hunt A.
Jones M.
Lloyd C.
McMurray A.
Matthews L.
Mercer S.
Milne S.
Mullikin J.C.
Mungall A.
Plumb R.
Ross M.
Shownkeen R.
Sims S.
Waterston R.H.
Wilson R.K.
Hillier L.W.
McPherson J.D.
Marra M.A.
Mardis E.R.
Fulton L.A.
Chinwalla A.T.
Pepin K.H.
Gish W.R.
Chissoe S.L.
Wendl M.C.
Delehaunty K.D.
Miner T.L.
Delehaunty A.
Kramer J.B.
Cook L.L.
Fulton R.S.
Johnson D.L.
Minx P.J.
Clifton S.W.
Hawkins T.
Branscomb E.
Predki P.
Richardson P.
Wenning S.
Slezak T.
Doggett N.
Cheng J.F.
Olsen A.
Lucas S.
Elkin C.
Uberbacher E.
Frazier M.
Gibbs R.A.
Muzny D.M.
Scherer S.E.
Bouck J.B.
Sodergren E.J.
Worley K.C.
Rives C.M.
Gorrell J.H.
Metzker M.L.
Naylor S.L.
Kucherlapati R.S.
Nelson D.L.
Weinstock G.M.
Sakaki Y.
Fujiyama A.
Hattori M.
Yada T.
Toyoda A.
Itoh T.
Kawagoe C.
Watanabe H.
Totoki Y.
Taylor T.
Weissenbach J.
Heilig R.
Saurin W.
Artiguenave F.
Brottier P.
Bruls T.
Pelletier E.
Robert C.
Wincker P.
Smith D.R.
Doucette-Stamm L.
Rubenfield M.
Weinstock K.
Lee H.M.
Dubois J.
Rosenthal A.
Platzer M.
Nyakatura G.
Taudien S.
Rump A.
Yang H.
Yu J.
Wang J.
Huang G.
Gu J.
Hood L.
Rowen L.
Madan A.
Qin S.
Davis R.W.
Federspiel N.A.
Abola A.P.
Proctor M.J.
Myers R.M.
Schmutz J.
Dickson M.
Grimwood J.
Cox D.R.
Olson M.V.
Kaul R.
Raymond C.
Shimizu N.
Kawasaki K.
Minoshima S.
Evans G.A.
Athanasiou M.
Schultz R.
Roe B.A.
Chen F.
Pan H.
Ramser J.
Lehrach H.
Reinhardt R.
McCombie W.R.
de la Bastide M.
Dedhia N.
Blocker H.
Hornischer K.
Nordsiek G.
Agarwala R.
Aravind L.
Bailey J.A.
Bateman A.
Batzoglou S.
Birney E.
Bork P.
Brown D.G.
Burge C.B.
Cerutti L.
Chen H.C.
Church D.
Clamp M.
Copley R.R.
Doerks T.
Eddy S.R.
Eichler E.E.
Furey T.S.
Galagan J.
Gilbert J.G.
Harmon C.
Hayashizaki Y.
Haussler D.
Hermjakob H.
Hokamp K.
Jang W.
Johnson L.S.
Jones T.A.
Kasif S.
Kaspryzk A.
Kennedy S.
Kent W.J.
Kitts P.
Koonin E.V.
Korf I.
Kulp D.
Lancet D.
Lowe T.M.
McLysaght A.
Mikkelsen T.
Moran J.V.
Mulder N.
Pollara V.J.
Ponting C.P.
Schuler G.
Schultz J.
Slater G.
Smit A.F.
Stupka E.
Szustakowski J.
Thierry-Mieg D.
Thierry-Mieg J.
Wagner L.
Wallis J.
Wheeler R.
Williams A.
Wolf Y.I.
Wolfe K.H.
Yang S.P.
Yeh R.F.
Collins F.
Guyer M.S.
Peterson J.
Felsenfeld A.
Wetterstrand K.A.
Patrinos A.
Morgan M.J.
de Jong P.
Catanese J.J.
Osoegawa K.
Shizuya H.
Choi S.
Chen Y.J.

Initial sequencing and analysis of the human genome.

Finishing the euchromatic sequence of the human genome.

Zody M.C.
Garber M.
Adams D.J.
Sharpe T.
Harrow J.
Lupski J.R.
Nicholson C.
Searle S.M.
Wilming L.
Young S.K.
Abouelleil A.
Allen N.R.
Bi W.
Bloom T.
Borowsky M.L.
Bugalter B.E.
Butler J.
Chang J.L.
Chen C.K.
Cook A.
Corum B.
Cuomo C.A.
de Jong P.J.
DeCaprio D.
Dewar K.
FitzGerald M.
Gilbert J.
Gibson R.
Gnerre S.
Goldstein S.
Grafham D.V.
Grocock R.
Hafez N.
Hagopian D.S.
Hart E.
Norman C.H.
Humphray S.
Jaffe D.B.
Jones M.
Kamal M.
Khodiyar V.K.
LaButti K.
Laird G.
Lehoczky J.
Liu X.
Lokyitsang T.
Loveland J.
Lui A.
Macdonald P.
Major J.E.
Matthews L.
Mauceli E.
McCarroll S.A.
Mihalev A.H.
Mudge J.
Nguyen C.
Nicol R.
O'Leary S.B.
Osoegawa K.
Schwartz D.C.
Shaw-Smith C.
Stankiewicz P.
Steward C.
Swarbreck D.
Venkataraman V.
Whittaker C.A.
Yang X.
Zimmer A.R.
Bradley A.
Hubbard T.
Birren B.W.
Rogers J.
Lander E.S.
Nusbaum C.

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

MFS general substrate transporter like domains

Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Pleocyemata Brachyura Eubrachyura Portunoidea Portunidae Portuninae Scylla

Disordered

Low complexity


Helical

axial binding residue


F:translation elongation factor activity


axial binding residue


F:cysteine-type endopeptidase inhibitor activity


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Noctuoidea Noctuidae Hadeninae Mythimna

Identification and sex expression profiles of olfactory-related genes in Mythimna loreyi based on antennal transcriptome analysis.

Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3


WD

Disordered

C:Cul4A-RING E3 ubiquitin ligase complex

P:proteasome-mediated ubiquitin-dependent protein catabolic process

YVTN repeat-like/Quinoprotein amine dehydrogenase


Disordered

Acidic residues

Gregory S.G.
Barlow K.F.
McLay K.E.
Kaul R.
Swarbreck D.
Dunham A.
Scott C.E.
Howe K.L.
Woodfine K.
Spencer C.C.
Jones M.C.
Gillson C.
Searle S.
Zhou Y.
Kokocinski F.
McDonald L.
Evans R.
Phillips K.
Atkinson A.
Cooper R.
Jones C.
Hall R.E.
Andrews T.D.
Lloyd C.
Ainscough R.
Almeida J.P.
Ambrose K.D.
Anderson F.
Andrew R.W.
Ashwell R.I.
Aubin K.
Babbage A.K.
Bagguley C.L.
Bailey J.
Beasley H.
Bethel G.
Bird C.P.
Bray-Allen S.
Brown J.Y.
Brown A.J.
Buckley D.
Burton J.
Bye J.
Carder C.
Chapman J.C.
Clark S.Y.
Clarke G.
Clee C.
Cobley V.
Collier R.E.
Corby N.
Coville G.J.
Davies J.
Deadman R.
Dunn M.
Earthrowl M.
Ellington A.G.
Errington H.
Frankish A.
Frankland J.
French L.
Garner P.
Garnett J.
Gay L.
Ghori M.R.
Gibson R.
Gilby L.M.
Gillett W.
Glithero R.J.
Grafham D.V.
Griffiths C.
Griffiths-Jones S.
Grocock R.
Hammond S.
Harrison E.S.
Hart E.
Haugen E.
Heath P.D.
Holmes S.
Holt K.
Howden P.J.
Hunt A.R.
Hunt S.E.
Hunter G.
Isherwood J.
James R.
Johnson C.
Johnson D.
Joy A.
Kay M.
Kershaw J.K.
Kibukawa M.
Kimberley A.M.
King A.
Knights A.J.
Lad H.
Laird G.
Lawlor S.
Leongamornlert D.A.
Lloyd D.M.
Loveland J.
Lovell J.
Lush M.J.
Lyne R.
Martin S.
Mashreghi-Mohammadi M.
Matthews L.
Matthews N.S.
McLaren S.
Milne S.
Mistry S.
Moore M.J.
Nickerson T.
O'Dell C.N.
Oliver K.
Palmeiri A.
Palmer S.A.
Parker A.
Patel D.
Pearce A.V.
Peck A.I.
Pelan S.
Phelps K.
Phillimore B.J.
Plumb R.
Rajan J.
Raymond C.
Rouse G.
Saenphimmachak C.
Sehra H.K.
Sheridan E.
Shownkeen R.
Sims S.
Skuce C.D.
Smith M.
Steward C.
Subramanian S.
Sycamore N.
Tracey A.
Tromans A.
Van Helmond Z.
Wall M.
Wallis J.M.
White S.
Whitehead S.L.
Wilkinson J.E.
Willey D.L.
Williams H.
Wilming L.
Wray P.W.
Wu Z.
Coulson A.
Vaudin M.
Sulston J.E.
Durbin R.
Hubbard T.
Wooster R.
Dunham I.
Carter N.P.
McVean G.
Ross M.T.
Harrow J.
Olson M.V.
Beck S.
Rogers J.
Bentley D.R.
Banerjee R.
Bryant S.P.
Burford D.C.
Burrill W.D.
Clegg S.M.
Dhami P.
Dovey O.
Faulkner L.M.
Gribble S.M.
Langford C.F.
Pandian R.D.
Porter K.M.
Prigmore E.

The DNA sequence and biological annotation of human chromosome 1.


Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1

EGF-like

EGF-like

EGF-like

EGF-like

EGF-like

Lacks conserved residue(s) required for the propagation of feature annotation


Deoxyribonuclease

Endonuclease/exonuclease/phosphatase

Essential for enzymatic activity


Hillier L.W.
Graves T.A.
Fulton R.S.
Fulton L.A.
Pepin K.H.
Minx P.
Wagner-McPherson C.
Layman D.
Wylie K.
Sekhon M.
Becker M.C.
Fewell G.A.
Delehaunty K.D.
Miner T.L.
Nash W.E.
Kremitzki C.
Oddy L.
Du H.
Sun H.
Bradshaw-Cordum H.
Ali J.
Carter J.
Cordes M.
Harris A.
Isak A.
van Brunt A.
Nguyen C.
Du F.
Courtney L.
Kalicki J.
Ozersky P.
Abbott S.
Armstrong J.
Belter E.A.
Caruso L.
Cedroni M.
Cotton M.
Davidson T.
Desai A.
Elliott G.
Erb T.
Fronick C.
Gaige T.
Haakenson W.
Haglund K.
Holmes A.
Harkins R.
Kim K.
Kruchowski S.S.
Strong C.M.
Grewal N.
Goyea E.
Hou S.
Levy A.
Martinka S.
Mead K.
McLellan M.D.
Meyer R.
Randall-Maher J.
Tomlinson C.
Dauphin-Kohlberg S.
Kozlowicz-Reilly A.
Shah N.
Swearengen-Shahid S.
Snider J.
Strong J.T.
Thompson J.
Yoakum M.
Leonard S.
Pearman C.
Trani L.
Radionenko M.
Waligorski J.E.
Wang C.
Rock S.M.
Tin-Wollam A.M.
Maupin R.
Latreille P.
Wendl M.C.
Yang S.P.
Pohl C.
Wallis J.W.
Spieth J.
Bieri T.A.
Berkowicz N.
Nelson J.O.
Osborne J.
Ding L.
Meyer R.
Sabo A.
Shotland Y.
Sinha P.
Wohldmann P.E.
Cook L.L.
Hickenbotham M.T.
Eldred J.
Williams D.
Jones T.A.
She X.
Ciccarelli F.D.
Izaurralde E.
Taylor J.
Schmutz J.
Myers R.M.
Cox D.R.
Huang X.
McPherson J.D.
Mardis E.R.
Clifton S.W.
Warren W.C.
Chinwalla A.T.
Eddy S.R.
Marra M.A.
Ovcharenko I.
Furey T.S.
Miller W.
Eichler E.E.
Bork P.
Suyama M.
Torrents D.
Waterston R.H.
Wilson R.K.

Generation and annotation of the DNA sequences of human chromosomes 2 and 4.


Archaea
Promethearchaeati
Promethearchaeota
Promethearchaeia
Promethearchaeales
Promethearchaeaceae
Candidatus Harpocratesius

PAZ

Piwi

Bastiaanssen C.
Bobadilla Ugarte P.
Kim K.
Finocchio G.
Feng Y.
Anzelon T.A.
Kostlbacher S.
Tamarit D.
Ettema T.J.G.
Jinek M.
MacRae I.J.
Joo C.
Swarts D.C.
Wu F.

RNA-guided RNA silencing by an Asgard archaeal Argonaute.

STRUCTURE BY ELECTRON MICROSCOPY (3.40 ANGSTROMS)

Ribonuclease H-like superfamily/Ribonuclease H

EUKARYOTIC TRANSLATION INITIATION FACTOR 2C


Eukaryota Metazoa Echinodermata Eleutherozoa Echinozoa Holothuroidea Aspidochirotacea Aspidochirotida Stichopodidae Apostichopus

Guanylate-binding protein N-terminal

P-loop containing nucleotide triphosphate hydrolases

Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain

P-loop containing nucleoside triphosphate hydrolases


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Auchenorrhyncha Membracoidea Cicadellidae Typhlocybinae Empoascini Empoasca

Disordered

Disordered

Low complexity

Low complexity

Low complexity

Low complexity

Acidic residues

Low complexity

C:cytoplasmic side of apical plasma membrane

P:positive regulation of hippo signaling

FERM DOMAIN (PROTEIN4.1-EZRIN-RADIXIN-MOESIN) FAMILY


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Pleocyemata Brachyura Eubrachyura Potamoidea Potamidae Trichopotamon

Cation-independent mannose-6-phosphate receptor-like protein

MRH

Mannose-6-phosphate receptor binding domain

MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1

MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER


Mediator of RNA polymerase II transcription subunit 15-like protein

ARC105/Med15 mediator subunit central

ARC105/Med15 mediator subunit C-terminal

MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15


Eukaryota Fungi Dikarya Ascomycota Pezizomycotina Eurotiomycetes Eurotiomycetidae Eurotiales Aspergillaceae Penicillium

Arginine-containing cyclodipeptide synthase pthA

Conserved DDXXE motif

Yee D.A.
Niwa K.
Perlatti B.
Chen M.
Li Y.
Tang Y.

Genome mining for unknown-unknown natural products.

NUCLEOTIDE SEQUENCE [MRNA]
FUNCTION
CATALYTIC ACTIVITY
PATHWAY

Arginine-containing cyclodipeptide synthase; part of the cluster that mediates the biosynthesis of a highly modified cyclo-arginine-aspartate dipeptide (cRD) (PubMed:36702957). Within the pathway, pthA acts as the scaffold-generating enzyme and is responsible for formation of the cyclo-Arg-Asp diketopiperazine (cRW) from L-arginyl-tRNA(Arg) + L-aspartyl-tRNA(Asp) (PubMed:36702957). Additional enzymes from the cluster then further modify the cyclo-Arg-Asp diketopiperazine (cRW) scaffold (Probable)

L-aspartyl-tRNA(Asp) + L-arginyl-tRNA(Arg) = cyclo(L-arginyl-L-aspartyl) + tRNA(Asp) + tRNA(Arg) + 2 H(+)

The conserved DDXXE motif is essential for catalytic activity

Belongs to the arginine-containing cyclodipeptide synthase family


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Hymenoptera Apocrita Aculeata Apoidea Anthophila Apidae Scaptotrigona

Leon-Estrada N.
Garcia-Fajardo L.V.
Rojas-Leon J.C.
Guillen-Navarro K.

Pheromone/general odorant binding protein domain


Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Cephalopoda Coleoidea Octopodiformes Octopoda Incirrata Octopodidae Callistoctopus

Disordered

Polar residues

Type I PLP-dependent aspartate aminotransferase-like (Major domain)

GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE

Belongs to the group II decarboxylase family


Helical

CoA carboxyltransferase C-terminal

F:carboxyl- or carbamoyltransferase activity

2-enoyl-CoA Hydratase, Chain A, domain 1

N(6)-carboxybiotinyl-L-lysyl-[protein] + acetyl-CoA = N(6)-biotinyl-L-lysyl-[protein] + malonyl-CoA


Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Eukaryota Fungi Dikarya Ascomycota Saccharomycotina Saccharomycetes Saccharomycetales Saccharomycetaceae Saccharomyces

Uncharacterized protein YMR106W-A

Bowman S.
Churcher C.M.
Badcock K.
Brown D.
Chillingworth T.
Connor R.
Dedman K.
Devlin K.
Gentles S.
Hamlin N.
Hunt S.
Jagels K.
Lye G.
Moule S.
Odell C.
Pearson D.
Rajandream M.A.
Rice P.
Skelton J.
Walsh S.V.
Whitehead S.
Barrell B.G.

The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.

Engel S.R.
Dietrich F.S.
Fisk D.G.
Binkley G.
Balakrishnan R.
Costanzo M.C.
Dwight S.S.
Hitz B.C.
Karra K.
Nash R.S.
Weng S.
Wong E.D.
Lloyd P.
Skrzypek M.S.
Miyasato S.R.
Simison M.
Cherry J.M.

The reference genome sequence of Saccharomyces cerevisiae: Then and now.

Engel S.R.
Wong E.D.
Nash R.S.
Aleksander S.
Alexander M.
Douglass E.
Karra K.
Miyasato S.R.
Simison M.
Skrzypek M.S.
Weng S.
Cherry J.M.

New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources.

Biological factors and statistical limitations prevent detection of most noncanonical proteins by mass spectrometry.


Bacteria Bacillati Bacillota Bacilli Bacillales Paenibacillaceae Paenibacillus

Extracellular domain of a sensor histidine kinase NagS

Cache

Characterization of the extracellular domain of sensor histidine kinase NagS from Paenibacillus sp. str. FPU-7: nagS interacts with oligosaccharide binding protein NagB1 in complexes with N, N'-diacetylchitobiose.


Diversification of freshwater crabs on the sky islands in the Hengduan Mountains Region, China.


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Laurasiatheria Artiodactyla Ruminantia Pecora Cervidae Cervinae Cervus

Disordered

Basic residues


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Acari Acariformes Trombidiformes Prostigmata Eleutherengona Heterostigmata Tarsonemoidea Tarsonemidae Polyphagotarsonemus

Glycosyl hydrolase family 30 TIM-barrel

Glycosyl hydrolase family 30 beta sandwich

Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).

P:negative regulation of cellular component organization

P:negative regulation of macromolecule metabolic process

P:positive regulation of protein metabolic process

a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose

a beta-D-glucosylceramide + H2O = an N-acyl-sphingoid base + D-glucose

an N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + H2O = an N-acyl-15-methylhexadecasphing-4-enine + D-glucose

Lipid metabolism; sphingolipid metabolism

Belongs to the glycosyl hydrolase 30 family


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Peiratinae Ectomocoris


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Pleocyemata Brachyura Eubrachyura Potamoidea Potamidae Aparapotamon

Disordered

Disordered

Basic residues

Basic and acidic residues

F:DNA-binding transcription factor activity

F:RNA polymerase II cis-regulatory region sequence-specific DNA binding

P:regulation of transcription by RNA polymerase II

zinc finger and SCAN domain-containing protein 29

Belongs to the krueppel C2H2-type zinc-finger protein family


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Stenopodainae Oncocephalus

Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Sternorrhyncha Coccoidea Pseudococcidae Maconellicoccus

axial binding residue

Selvamani S.B.
Negi N.
Nagarjuna Reddy K.V.
Ramasamy G.G.

Identification of Cytochrome P450s in Maconellicoccus hirsutus.

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


ATP-binding cassette sub-family F member 1-like protein

ABC transporter

Putative ATP-binding cassette family ATPase

P-loop containing nucleotide triphosphate hydrolases

ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1

P-loop containing nucleoside triphosphate hydrolases


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae rosids fabids Rosales Elaeagnaceae Hippophae

MADS-box

Zhao J.
Xu Y.
Zhang Z.
Zhao M.
Li K.
Wang F.
Sun K.

Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.

F:DNA-binding transcription factor activity, RNA polymerase II-specific

P:positive regulation of transcription by RNA polymerase II


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae asterids lamiids Gentianales Apocynaceae Asclepiadoideae Marsdenieae Gymnema

NB-ARC

Disease resistance protein At4g27190-like leucine-rich repeats

Transcriptomic revealing of plant pathogen interaction in Gymnema sylvestre.

Helical domain of apoptotic protease-activating factors

Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

Belongs to the disease resistance NB-LRR family


Eukaryota Metazoa Porifera Demospongiae Verongimorpha Chondrillida Halisarcidae Halisarca

Disordered

Low complexity

Gly residues

F:extracellular matrix structural constituent conferring tensile strength


XlCGF8.2DB-like gastrula zinc finger protein

RB-associated KRAB zinc finger protein-like

GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Pleocyemata Brachyura Eubrachyura Potamoidea Potamidae Tenuipotamon

Helical

Helical

Disordered

Basic and acidic residues

P:piecemeal microautophagy of the nucleus

P:protein localization to phagophore assembly site

Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion

Lacks conserved residue(s) required for the propagation of feature annotation


Takout-proteins of Maconellicoccus hirsutus.

Haemolymph juvenile hormone binding protein

CIRCADIAN CLOCK-CONTROLLED PROTEIN-LIKE PROTEIN


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Zygaenoidea Limacodidae Comana

Goudarzi M.H.
Robinson S.D.
Cardoso F.C.
Mitchell M.L.
Cook L.G.
King G.F.
Walker A.A.

Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).


Helical

axial binding residue

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Polychaeta Sedentaria Canalipalpata Terebellida Terebelliformia Alvinellidae Alvinella

Interchain

Longo M.A.
Roy S.
Chen Y.
Tomaszowski K.H.
Arvai A.S.
Pepper J.T.
Boisvert R.A.
Kunnimalaiyaan S.
Keshvani C.
Schild D.
Bacolla A.
Williams G.J.
Tainer J.A.
Schlacher K.

RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles.

X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) IN COMPLEX WITH ZN(2+)


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Leucinodes

Helical

Helical

Helical

Helical

Helical

Helical

Pathak J.
Thiruvengadam V.
Gracy G.R.
M M.


Eukaryota
Metazoa
Spiralia
Lophotrochozoa
Annelida
Polychaeta
Errantia
Phyllodocida
Nereididae
Hediste
Hediste diversicolor species group

Helical

Helical

Helical

Cytochrome b5 heme-binding

F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

Cytochrome b5-like heme/steroid binding domain

Belongs to the fatty acid desaturase type 1 family


Eukaryota Fungi Dikarya Ascomycota Pezizomycotina Dothideomycetes Pleosporomycetidae Pleosporales Pleosporineae Didymellaceae Didymella


Zdenek C.N.
Cardoso F.C.
Robinson S.D.
Mercedes R.S.
Raidjoe E.R.
Hernandez-Vargas M.J.
Jin J.
Corzo G.
Vetter I.
King G.F.
Fry B.G.
Walker A.


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Neopterygii Teleostei Ostariophysi Cypriniformes Danionidae Danioninae Danio

Disordered

Polar residues

Polar residues

Howe K.
Clark M.D.
Torroja C.F.
Torrance J.
Berthelot C.
Muffato M.
Collins J.E.
Humphray S.
McLaren K.
Matthews L.
McLaren S.
Sealy I.
Caccamo M.
Churcher C.
Scott C.
Barrett J.C.
Koch R.
Rauch G.J.
White S.
Chow W.
Kilian B.
Quintais L.T.
Guerra-Assuncao J.A.
Zhou Y.
Gu Y.
Yen J.
Vogel J.H.
Eyre T.
Redmond S.
Banerjee R.
Chi J.
Fu B.
Langley E.
Maguire S.F.
Laird G.K.
Lloyd D.
Kenyon E.
Donaldson S.
Sehra H.
Almeida-King J.
Loveland J.
Trevanion S.
Jones M.
Quail M.
Willey D.
Hunt A.
Burton J.
Sims S.
McLay K.
Plumb B.
Davis J.
Clee C.
Oliver K.
Clark R.
Riddle C.
Elliot D.
Eliott D.
Threadgold G.
Harden G.
Ware D.
Begum S.
Mortimore B.
Mortimer B.
Kerry G.
Heath P.
Phillimore B.
Tracey A.
Corby N.
Dunn M.
Johnson C.
Wood J.
Clark S.
Pelan S.
Griffiths G.
Smith M.
Glithero R.
Howden P.
Barker N.
Lloyd C.
Stevens C.
Harley J.
Holt K.
Panagiotidis G.
Lovell J.
Beasley H.
Henderson C.
Gordon D.
Auger K.
Wright D.
Collins J.
Raisen C.
Dyer L.
Leung K.
Robertson L.
Ambridge K.
Leongamornlert D.
McGuire S.
Gilderthorp R.
Griffiths C.
Manthravadi D.
Nichol S.
Barker G.
Whitehead S.
Kay M.
Brown J.
Murnane C.
Gray E.
Humphries M.
Sycamore N.
Barker D.
Saunders D.
Wallis J.
Babbage A.
Hammond S.
Mashreghi-Mohammadi M.
Barr L.
Martin S.
Wray P.
Ellington A.
Matthews N.
Ellwood M.
Woodmansey R.
Clark G.
Cooper J.
Cooper J.
Tromans A.
Grafham D.
Skuce C.
Pandian R.
Andrews R.
Harrison E.
Kimberley A.
Garnett J.
Fosker N.
Hall R.
Garner P.
Kelly D.
Bird C.
Palmer S.
Gehring I.
Berger A.
Dooley C.M.
Ersan-Urun Z.
Eser C.
Geiger H.
Geisler M.
Karotki L.
Kirn A.
Konantz J.
Konantz M.
Oberlander M.
Rudolph-Geiger S.
Teucke M.
Lanz C.
Raddatz G.
Osoegawa K.
Zhu B.
Rapp A.
Widaa S.
Langford C.
Yang F.
Schuster S.C.
Carter N.P.
Harrow J.
Ning Z.
Herrero J.
Searle S.M.
Enright A.
Geisler R.
Plasterk R.H.
Lee C.
Westerfield M.
de Jong P.J.
Zon L.I.
Postlethwait J.H.
Nusslein-Volhard C.
Hubbard T.J.
Roest Crollius H.
Rogers J.
Stemple D.L.

The zebrafish reference genome sequence and its relationship to the human genome.


Helical

Helical

Helical

axial binding residue

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen


MADS-box

F:cis-regulatory region sequence-specific DNA binding

F:DNA-binding transcription factor activity, RNA polymerase II-specific

P:positive regulation of transcription by RNA polymerase II


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Glires Rodentia Myomorpha Muroidea Muridae Murinae Mus Mus

Helical

Peptidase M13 N-terminal

Church D.M.
Goodstadt L.
Hillier L.W.
Zody M.C.
Goldstein S.
She X.
Bult C.J.
Agarwala R.
Cherry J.L.
DiCuccio M.
Hlavina W.
Kapustin Y.
Meric P.
Maglott D.
Birtle Z.
Marques A.C.
Graves T.
Zhou S.
Teague B.
Potamousis K.
Churas C.
Place M.
Herschleb J.
Runnheim R.
Forrest D.
Amos-Landgraf J.
Schwartz D.C.
Cheng Z.
Lindblad-Toh K.
Eichler E.E.
Ponting C.P.

Lineage-specific biology revealed by a finished genome assembly of the mouse.

Church D.M.
Schneider V.A.
Graves T.
Auger K.
Cunningham F.
Bouk N.
Chen H.C.
Agarwala R.
McLaren W.M.
Ritchie G.R.
Albracht D.
Kremitzki M.
Rock S.
Kotkiewicz H.
Kremitzki C.
Wollam A.
Trani L.
Fulton L.
Fulton R.
Matthews L.
Whitehead S.
Chow W.
Torrance J.
Dunn M.
Harden G.
Threadgold G.
Wood J.
Collins J.
Heath P.
Griffiths G.
Pelan S.
Grafham D.
Eichler E.E.
Weinstock G.
Mardis E.R.
Wilson R.K.
Howe K.
Flicek P.
Hubbard T.

Modernizing reference genome assemblies.

ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED

Metalloproteases ('zincins'), catalytic domain


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Clitellata Oligochaeta Enchytraeida Enchytraeidae Enchytraeus

PAZ

Piwi

Disordered

Basic residues

Low complexity

Gly residues

Kostyuchenko R.P.
Nikanorova D.D.
Amosov A.V.

Germ Line/Multipotency Genes Show Differential Expression during Embryonic Development of the Annelid Enchytraeus coronatus.

P:regulatory ncRNA-mediated gene silencing

Ribonuclease H-like superfamily/Ribonuclease H

EUKARYOTIC TRANSLATION INITIATION FACTOR 2C

Belongs to the argonaute family. Piwi subfamily


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Zygaenoidea Megalopygidae Megalopyge

Walker A.A.
Robinson S.D.
Merritt D.J.
Cardoso F.C.
Goudarzi M.H.
Mercedes R.S.
Eagles D.A.
Cooper P.
Zdenek C.N.
Fry B.G.
Hall D.W.
Vetter I.
King G.F.

Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae).

NUCLEOTIDE SEQUENCE [MRNA]
MASS SPECTROMETRY
SYNTHESIS OF 24-40
SUBCELLULAR LOCATION
TISSUE SPECIFICITY
DEVELOPMENTAL STAGE


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Amphibia Batrachia Anura Neobatrachia Ranoidea Ranidae Nidirana

Zheng P.
Gong Y.
Wang B.
Yu H.
Huang S.
Liao X.
Jiang J.
Ran J.
Xie F.

Love Hug-Functional Validation of Nuptial Pad-Secreted Pheromone in Anurans.


Eukaryota Fungi Dikarya Ascomycota Saccharomycotina Saccharomycetes Saccharomycetales Saccharomycetaceae Saccharomyces

Uncharacterized protein YFR035W-A

Helical

Murakami Y.
Naitou M.
Hagiwara H.
Shibata T.
Ozawa M.
Sasanuma S.
Sasanuma M.
Tsuchiya Y.
Soeda E.
Yokoyama K.
Yamazaki M.
Tashiro H.
Eki T.

Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae.

The reference genome sequence of Saccharomyces cerevisiae: Then and now.

New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources.

Biological factors and statistical limitations prevent detection of most noncanonical proteins by mass spectrometry.

F:mitochondrion autophagosome adaptor activity

CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Acari Acariformes Trombidiformes Prostigmata Eleutherengona Heterostigmata Tarsonemoidea Tarsonemidae Polyphagotarsonemus

Helical

Helical

Helical

Helical

Helical

Helical

Helical

G-protein coupled receptors family 1 profile

Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).

Rhodopsin 7-helix transmembrane proteins

ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR

Family A G protein-coupled receptor-like

Belongs to the G-protein coupled receptor 1 family


NUCLEOTIDE SEQUENCE [MRNA]
MASS SPECTROMETRY
RECOMBINANT EXPRESSION
SUBCELLULAR LOCATION
TISSUE SPECIFICITY
DEVELOPMENTAL STAGE


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Stenopodainae Oncocephalus

Protease inhibitor

Pacifastin

Pacifastin

Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).

F:serine-type endopeptidase inhibitor activity

Belongs to the protease inhibitor I19 family

Lacks conserved residue(s) required for the propagation of feature annotation


Bifunctional lysine-specific demethylase and histidyl-hydroxylase

JmjC

Disordered

Basic residues

Polar residues

JmjC domain-containing ribosomal oxygenase (ROX), dimer domain

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles

L-histidyl-[protein] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-histidyl-[protein] + succinate + CO2

L-histidyl-[ribosomal protein uL15] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-histidyl-[ribosomal protein uL15] + succinate + CO2

Belongs to the ROX family. MINA53 subfamily


Helical

Helical

Helical


Peptidase S1

Belongs to the peptidase S1 family. CLIP subfamily


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Peiratinae Ectomocoris


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Clitellata Hirudinea Hirudinida Hirudiniformes Hirudinidae Hirudo


Eukaryota Fungi Dikarya Basidiomycota Agaricomycotina Agaricomycetes Agaricomycetidae Agaricales Tricholomatineae Entolomataceae Clitopilus

Mechanistic characterisation of the diterpene synthase for clitopilene and identification of isopentalenene synthase from the fungus Clitopilus passeckerianus.


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae asterids lamiids Solanales Solanaceae Solanoideae Physaleae Physalis

Disordered

Editing multiple genes in Physalis pubescens provides implications for creating new germplasm and varieties of Physalis crops.

F:receptor serine/threonine kinase binding

Belongs to the CLV3/ESR signal peptide family


Eukaryota Metazoa Porifera Demospongiae Verongimorpha Chondrillida Halisarcidae Halisarca

VWFA


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Sternorrhyncha Coccoidea Pseudococcidae Maconellicoccus

Helical

Identification of Cytochrome P450s in Maconellicoccus hirsutus.

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo

Lander E.S.
Linton L.M.
Birren B.
Nusbaum C.
Zody M.C.
Baldwin J.
Devon K.
Dewar K.
Doyle M.
FitzHugh W.
Funke R.
Gage D.
Harris K.
Heaford A.
Howland J.
Kann L.
Lehoczky J.
LeVine R.
McEwan P.
McKernan K.
Meldrim J.
Mesirov J.P.
Miranda C.
Morris W.
Naylor J.
Raymond C.
Rosetti M.
Santos R.
Sheridan A.
Sougnez C.
Stange-Thomann N.
Stojanovic N.
Subramanian A.
Wyman D.
Rogers J.
Sulston J.
Ainscough R.
Beck S.
Bentley D.
Burton J.
Clee C.
Carter N.
Coulson A.
Deadman R.
Deloukas P.
Dunham A.
Dunham I.
Durbin R.
French L.
Grafham D.
Gregory S.
Hubbard T.
Humphray S.
Hunt A.
Jones M.
Lloyd C.
McMurray A.
Matthews L.
Mercer S.
Milne S.
Mullikin J.C.
Mungall A.
Plumb R.
Ross M.
Shownkeen R.
Sims S.
Waterston R.H.
Wilson R.K.
Hillier L.W.
McPherson J.D.
Marra M.A.
Mardis E.R.
Fulton L.A.
Chinwalla A.T.
Pepin K.H.
Gish W.R.
Chissoe S.L.
Wendl M.C.
Delehaunty K.D.
Miner T.L.
Delehaunty A.
Kramer J.B.
Cook L.L.
Fulton R.S.
Johnson D.L.
Minx P.J.
Clifton S.W.
Hawkins T.
Branscomb E.
Predki P.
Richardson P.
Wenning S.
Slezak T.
Doggett N.
Cheng J.F.
Olsen A.
Lucas S.
Elkin C.
Uberbacher E.
Frazier M.
Gibbs R.A.
Muzny D.M.
Scherer S.E.
Bouck J.B.
Sodergren E.J.
Worley K.C.
Rives C.M.
Gorrell J.H.
Metzker M.L.
Naylor S.L.
Kucherlapati R.S.
Nelson D.L.
Weinstock G.M.
Sakaki Y.
Fujiyama A.
Hattori M.
Yada T.
Toyoda A.
Itoh T.
Kawagoe C.
Watanabe H.
Totoki Y.
Taylor T.
Weissenbach J.
Heilig R.
Saurin W.
Artiguenave F.
Brottier P.
Bruls T.
Pelletier E.
Robert C.
Wincker P.
Smith D.R.
Doucette-Stamm L.
Rubenfield M.
Weinstock K.
Lee H.M.
Dubois J.
Rosenthal A.
Platzer M.
Nyakatura G.
Taudien S.
Rump A.
Yang H.
Yu J.
Wang J.
Huang G.
Gu J.
Hood L.
Rowen L.
Madan A.
Qin S.
Davis R.W.
Federspiel N.A.
Abola A.P.
Proctor M.J.
Myers R.M.
Schmutz J.
Dickson M.
Grimwood J.
Cox D.R.
Olson M.V.
Kaul R.
Raymond C.
Shimizu N.
Kawasaki K.
Minoshima S.
Evans G.A.
Athanasiou M.
Schultz R.
Roe B.A.
Chen F.
Pan H.
Ramser J.
Lehrach H.
Reinhardt R.
McCombie W.R.
de la Bastide M.
Dedhia N.
Blocker H.
Hornischer K.
Nordsiek G.
Agarwala R.
Aravind L.
Bailey J.A.
Bateman A.
Batzoglou S.
Birney E.
Bork P.
Brown D.G.
Burge C.B.
Cerutti L.
Chen H.C.
Church D.
Clamp M.
Copley R.R.
Doerks T.
Eddy S.R.
Eichler E.E.
Furey T.S.
Galagan J.
Gilbert J.G.
Harmon C.
Hayashizaki Y.
Haussler D.
Hermjakob H.
Hokamp K.
Jang W.
Johnson L.S.
Jones T.A.
Kasif S.
Kaspryzk A.
Kennedy S.
Kent W.J.
Kitts P.
Koonin E.V.
Korf I.
Kulp D.
Lancet D.
Lowe T.M.
McLysaght A.
Mikkelsen T.
Moran J.V.
Mulder N.
Pollara V.J.
Ponting C.P.
Schuler G.
Schultz J.
Slater G.
Smit A.F.
Stupka E.
Szustakowski J.
Thierry-Mieg D.
Thierry-Mieg J.
Wagner L.
Wallis J.
Wheeler R.
Williams A.
Wolf Y.I.
Wolfe K.H.
Yang S.P.
Yeh R.F.
Collins F.
Guyer M.S.
Peterson J.
Felsenfeld A.
Wetterstrand K.A.
Patrinos A.
Morgan M.J.
de Jong P.
Catanese J.J.
Osoegawa K.
Shizuya H.
Choi S.
Chen Y.J.

Initial sequencing and analysis of the human genome.

Mungall A.J.
Palmer S.A.
Sims S.K.
Edwards C.A.
Ashurst J.L.
Wilming L.
Jones M.C.
Horton R.
Hunt S.E.
Scott C.E.
Gilbert J.G.
Clamp M.E.
Bethel G.
Milne S.
Ainscough R.
Almeida J.P.
Ambrose K.D.
Andrews T.D.
Ashwell R.I.
Babbage A.K.
Bagguley C.L.
Bailey J.
Banerjee R.
Barker D.J.
Barlow K.F.
Bates K.
Beare D.M.
Beasley H.
Beasley O.
Bird C.P.
Blakey S.
Bray-Allen S.
Brook J.
Brown A.J.
Brown J.Y.
Burford D.C.
Burrill W.
Burton J.
Carder C.
Carter N.P.
Chapman J.C.
Clark S.Y.
Clark G.
Clee C.M.
Clegg S.
Cobley V.
Collier R.E.
Collins J.E.
Colman L.K.
Corby N.R.
Coville G.J.
Culley K.M.
Dhami P.
Davies J.
Dunn M.
Earthrowl M.E.
Ellington A.E.
Evans K.A.
Faulkner L.
Francis M.D.
Frankish A.
Frankland J.
French L.
Garner P.
Garnett J.
Ghori M.J.
Gilby L.M.
Gillson C.J.
Glithero R.J.
Grafham D.V.
Grant M.
Gribble S.
Griffiths C.
Griffiths M.
Hall R.
Halls K.S.
Hammond S.
Harley J.L.
Hart E.A.
Heath P.D.
Heathcott R.
Holmes S.J.
Howden P.J.
Howe K.L.
Howell G.R.
Huckle E.
Humphray S.J.
Humphries M.D.
Hunt A.R.
Johnson C.M.
Joy A.A.
Kay M.
Keenan S.J.
Kimberley A.M.
King A.
Laird G.K.
Langford C.
Lawlor S.
Leongamornlert D.A.
Leversha M.
Lloyd C.R.
Lloyd D.M.
Loveland J.E.
Lovell J.
Martin S.
Mashreghi-Mohammadi M.
Maslen G.L.
Matthews L.
McCann O.T.
McLaren S.J.
McLay K.
McMurray A.
Moore M.J.
Mullikin J.C.
Niblett D.
Nickerson T.
Novik K.L.
Oliver K.
Overton-Larty E.K.
Parker A.
Patel R.
Pearce A.V.
Peck A.I.
Phillimore B.
Phillips S.
Plumb R.W.
Porter K.M.
Ramsey Y.
Ranby S.A.
Rice C.M.
Ross M.T.
Searle S.M.
Sehra H.K.
Sheridan E.
Skuce C.D.
Smith S.
Smith M.
Spraggon L.
Squares S.L.
Steward C.A.
Sycamore N.
Tamlyn-Hall G.
Tester J.
Theaker A.J.
Thomas D.W.
Thorpe A.
Tracey A.
Tromans A.
Tubby B.
Wall M.
Wallis J.M.
West A.P.
White S.S.
Whitehead S.L.
Whittaker H.
Wild A.
Willey D.J.
Wilmer T.E.
Wood J.M.
Wray P.W.
Wyatt J.C.
Young L.
Younger R.M.
Bentley D.R.
Coulson A.
Durbin R.
Hubbard T.
Sulston J.E.
Dunham I.
Rogers J.
Beck S.

The DNA sequence and analysis of human chromosome 6.

Finishing the euchromatic sequence of the human genome.


Disordered

Disordered

Low complexity

Low complexity

Gly residues

Low complexity

Basic and acidic residues


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Lepidosauria Squamata Bifurcata Unidentata Episquamata Toxicofera Serpentes Colubroidea Viperidae Crotalinae Protobothrops

Protocetin subunit alpha

Fan-Yu Z.
Ren-Sheng J.
Xiao-Qin Y.
Ya-Nan L.
Qi-Yun Z.
Qian-Yun S.


Eukaryota Fungi Dikarya Ascomycota Pezizomycotina Sordariomycetes Sordariomycetidae Sordariales Chaetomiaceae Humicola

Fuscoatroside biosynthesis cluster protein D

Cytochrome P450 monooxygenase fsoD

Helical

axial binding residue

Cao Z.Q.
Wang G.Q.
Luo R.
Gao Y.H.
Lv J.M.
Qin S.Y.
Chen G.D.
Awakawa T.
Bao X.F.
Mei Q.H.
Yao X.S.
Hu D.
Abe I.
Gao H.

Biosynthesis of Enfumafungin-type Antibiotic Reveals an Unusual Enzymatic Fusion Pattern and Unprecedented C-C Bond Cleavage.

NUCLEOTIDE SEQUENCE [GENOMIC DNA]
FUNCTION
CATALYTIC ACTIVITY
PATHWAY
BIOTECHNOLOGY

Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of the enfumafungin-type antibiotic, fuscoatroside (PubMed:38654452). Within the pathway, fsoD catalyzes the hydroxylation at position C2 of isomotiol to produce 2-alpha-hydroxy-isomotiol. FsoD may also hydroxylate the intermediates 3-O-(beta-D-glucopyranosyl)-isomotiol and 2-deacetoxy-fuscoatroside at the same position C2 (PubMed:38654452). The fuscoatroside biosynthesis is initiated by the cyclization of 2,3(S)-oxidosqualene through FsoA's terpene cyclase (TC) domain, leading to the formation of the fernane skeleton isomotiol, harboring a fernane triterpene skeleton with a C8-C9 double bond. Subsequently, C2-alpha-hydroxylation mediated by fsoD results in the production of 2-alpha-hydroxy-isomotiol, which is further acetylated by fsoF. The glycosyltransferase (GT) domain of FsoA may convert isomotiol, 2-alpha-hydroxy-isomotiol, and the acetylated derivative of 2-alpha-hydroxy-isomotiol into their corresponding glycosides 3-O-(beta-D-glucopyranosyl)-isomotiol, 3-O-(beta-D-glucopyranosyl)-2-alpha-hydroxy-isomotiol, and 3-O-(beta-D-glucopyranosyl)-2-alpha-acetoxy-isomotiol, which then undergo oxidative cleavage under the action of fsoE to form s 2-deacetoxy-fuscoatroside, 2-deacetyl-fuscoatroside, and fuscoatroside, respectively. Although hydroxylation followed by acetylation of 3-O-(beta-D-glucopyranosyl)-isomotiol and 2-deacetoxy-fuscoatroside by fsoD and fsoF could not be ruled out, this process is likely to occur with difficulty due to bulky steric hindrance caused by the presence of a glycan at C3 in these compounds. Interestingly, fsoE can also utilize the aglycones isomotiol and 2-alpha-hydroxy-isomotiol as substrates to generate 19-beta-hydroxy-isomotiol and 2-alpha,19-beta-dihydroxy-isomotiol, respectively. These reactions occur with lower efficiency. Finally, fsoE can further convert 2-alpha,19-beta-dihydroxy-isomotiol into 2-alpha-hydroxy-ismotiol-19-one and 2-alpha-hydroxy-ismotiol-19-one into 2-deacetyl-3-deglucopyranosyl-fuscoatroside (PubMed:38654452)

isomotiol + reduced [NADPH--hemoprotein reductase] + O2 = 2alpha-hydroxyisomotiol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Secondary metabolite biosynthesis; terpenoid biosynthesis

Fuscoatroside and some of its derivatives show interesting antifungal activity against Candida albicans and Aspergillus niger


Gregory S.G.
Barlow K.F.
McLay K.E.
Kaul R.
Swarbreck D.
Dunham A.
Scott C.E.
Howe K.L.
Woodfine K.
Spencer C.C.
Jones M.C.
Gillson C.
Searle S.
Zhou Y.
Kokocinski F.
McDonald L.
Evans R.
Phillips K.
Atkinson A.
Cooper R.
Jones C.
Hall R.E.
Andrews T.D.
Lloyd C.
Ainscough R.
Almeida J.P.
Ambrose K.D.
Anderson F.
Andrew R.W.
Ashwell R.I.
Aubin K.
Babbage A.K.
Bagguley C.L.
Bailey J.
Beasley H.
Bethel G.
Bird C.P.
Bray-Allen S.
Brown J.Y.
Brown A.J.
Buckley D.
Burton J.
Bye J.
Carder C.
Chapman J.C.
Clark S.Y.
Clarke G.
Clee C.
Cobley V.
Collier R.E.
Corby N.
Coville G.J.
Davies J.
Deadman R.
Dunn M.
Earthrowl M.
Ellington A.G.
Errington H.
Frankish A.
Frankland J.
French L.
Garner P.
Garnett J.
Gay L.
Ghori M.R.
Gibson R.
Gilby L.M.
Gillett W.
Glithero R.J.
Grafham D.V.
Griffiths C.
Griffiths-Jones S.
Grocock R.
Hammond S.
Harrison E.S.
Hart E.
Haugen E.
Heath P.D.
Holmes S.
Holt K.
Howden P.J.
Hunt A.R.
Hunt S.E.
Hunter G.
Isherwood J.
James R.
Johnson C.
Johnson D.
Joy A.
Kay M.
Kershaw J.K.
Kibukawa M.
Kimberley A.M.
King A.
Knights A.J.
Lad H.
Laird G.
Lawlor S.
Leongamornlert D.A.
Lloyd D.M.
Loveland J.
Lovell J.
Lush M.J.
Lyne R.
Martin S.
Mashreghi-Mohammadi M.
Matthews L.
Matthews N.S.
McLaren S.
Milne S.
Mistry S.
Moore M.J.
Nickerson T.
O'Dell C.N.
Oliver K.
Palmeiri A.
Palmer S.A.
Parker A.
Patel D.
Pearce A.V.
Peck A.I.
Pelan S.
Phelps K.
Phillimore B.J.
Plumb R.
Rajan J.
Raymond C.
Rouse G.
Saenphimmachak C.
Sehra H.K.
Sheridan E.
Shownkeen R.
Sims S.
Skuce C.D.
Smith M.
Steward C.
Subramanian S.
Sycamore N.
Tracey A.
Tromans A.
Van Helmond Z.
Wall M.
Wallis J.M.
White S.
Whitehead S.L.
Wilkinson J.E.
Willey D.L.
Williams H.
Wilming L.
Wray P.W.
Wu Z.
Coulson A.
Vaudin M.
Sulston J.E.
Durbin R.
Hubbard T.
Wooster R.
Dunham I.
Carter N.P.
McVean G.
Ross M.T.
Harrow J.
Olson M.V.
Beck S.
Rogers J.
Bentley D.R.
Banerjee R.
Bryant S.P.
Burford D.C.
Burrill W.D.
Clegg S.M.
Dhami P.
Dovey O.
Faulkner L.M.
Gribble S.M.
Langford C.F.
Pandian R.D.
Porter K.M.
Prigmore E.

The DNA sequence and biological annotation of human chromosome 1.


Bacteria Bacillati Cyanobacteriota Cyanophyceae Oscillatoriophycideae Chroococcales Microcystaceae Pannus

Response regulatory

Disordered

Machado M.
Botero N.B.
Andreote A.P.D.
Feitosa A.M.T.
Popin R.
Sivonen K.
Fiore M.F.

Genomic insights into the taxonomy and metabolism of the cyanobacterium Pannus brasiliensis CCIBt3594.

P:phosphorelay signal transduction system

RESPONSE REGULATORY DOMAIN-CONTAINING PROTEIN

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Maruca


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Neopterygii Teleostei Ostariophysi Cypriniformes Danionidae Danioninae Danio

Serine hydrolase-like protein isoform X1

AB hydrolase-1

The zebrafish reference genome sequence and its relationship to the human genome.

SERINE HYDROLASE-LIKE PROTEIN DDB_G0286239


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Leucinodes

Odorant binding protein/PBP-general odorant binding protein

Pheromone/general odorant binding protein domain


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Glires Rodentia Myomorpha Muroidea Muridae Murinae Mus Mus

Truncated receptor-type tyrosine-protein phosphatase zeta transcript variant X1

Helical

Mouse RPTP-RPTP variants and expression.


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Neopterygii Teleostei Neoteleostei Acanthomorphata Eupercaria Sciaenidae Argyrosomus

P:cellular response to lipopolysaccharide

P:positive regulation of gene expression

P:regulation of non-canonical NF-kappaB signal transduction


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae rosids fabids Rosales Elaeagnaceae Hippophae

K-box

Zhao J.
Xu Y.
Zhang Z.
Zhao M.
Li K.
Wang F.
Sun K.

Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.

F:DNA-binding transcription factor activity


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Hymenoptera Apocrita Aculeata Apoidea Anthophila Apidae Xylocopa Koptortosoma

Alanine amide

Voltage-gated potassium channel impairing toxin

Shi N.
Szanto T.G.
He J.
Schroeder C.I.
Walker A.A.
Deuis J.R.
Vetter I.
Panyi G.
King G.F.
Robinson S.D.

Venom composition and pain-causing toxins of the Australian great carpenter bee Xylocopa aruana.

NUCLEOTIDE SEQUENCE [MRNA]
PROTEIN SEQUENCE OF 32-54
IDENTIFICATION BY MASS SPECTROMETRY
SUBCELLULAR LOCATION
AMIDATION AT ALA-54
SYNTHESIS OF 32-54

Toxin with weak activity on calcium-activated potassium (KCa) channels. Causes a small reversible block of human KCa2.1/KCNN1/SK1 and KCa2.2/KCNN2/SK2 (IC(50)=25.1 uM) currents

Negative results: does not show activity against Kv1.1/KCNA1, Kv1.2/KCNA2, and Kv1.3/KCNA3. Does not elicit any spontaneous pain behaviors after intraplantar injection in mice


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Clitellata Oligochaeta Enchytraeida Enchytraeidae Enchytraeus

Tudor

Tudor

Tudor

Tudor

Disordered

Disordered

Low complexity

Germ Line/Multipotency Genes Show Differential Expression during Embryonic Development of the Annelid Enchytraeus coronatus.


DEAD-box RNA helicase Q

Helicase ATP-binding

Helicase C-terminal

Disordered

Disordered

Q motif

Basic and acidic residues

Pro residues

Low complexity

Accumulation of soxC-expressing cells facilitated by MMPreg in the blastema formation in annelid Enchytraeus japonensis.

Probable ATP-dependent RNA helicase DDX4

P-loop containing nucleotide triphosphate hydrolases

P-loop containing nucleoside triphosphate hydrolases


Helical

Helical

axial binding residue

Selvamani S.B.
Negi N.
Nagarjuna Reddy K.V.
Ramasamy G.G.

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Helical

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Cadherin

Disordered

Polar residues

P:homophilic cell adhesion via plasma membrane adhesion molecules


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Zygaenoidea Limacodidae Comana

Goudarzi M.H.
Robinson S.D.
Cardoso F.C.
Mitchell M.L.
Cook L.G.
King G.F.
Walker A.A.

Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Polychaeta Errantia Phyllodocida Nereididae Platynereis

Elongation of very long chain fatty acids protein

Helical

Helical

Helical

Helical

Helical

K Homology

Disordered

Disordered

Polar residues

Basic residues

P:fatty acid elongation, monounsaturated fatty acid

P:fatty acid elongation, polyunsaturated fatty acid

P:fatty acid elongation, saturated fatty acid

P:very long-chain fatty acid biosynthetic process

ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 4

Eukaryotic type KH-domain (KH-domain type I)

a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA


K-box


Lineage-specific biology revealed by a finished genome assembly of the mouse.

Modernizing reference genome assemblies.


VWFA

Disordered

Low complexity

Howe K.
Clark M.D.
Torroja C.F.
Torrance J.
Berthelot C.
Muffato M.
Collins J.E.
Humphray S.
McLaren K.
Matthews L.
McLaren S.
Sealy I.
Caccamo M.
Churcher C.
Scott C.
Barrett J.C.
Koch R.
Rauch G.J.
White S.
Chow W.
Kilian B.
Quintais L.T.
Guerra-Assuncao J.A.
Zhou Y.
Gu Y.
Yen J.
Vogel J.H.
Eyre T.
Redmond S.
Banerjee R.
Chi J.
Fu B.
Langley E.
Maguire S.F.
Laird G.K.
Lloyd D.
Kenyon E.
Donaldson S.
Sehra H.
Almeida-King J.
Loveland J.
Trevanion S.
Jones M.
Quail M.
Willey D.
Hunt A.
Burton J.
Sims S.
McLay K.
Plumb B.
Davis J.
Clee C.
Oliver K.
Clark R.
Riddle C.
Elliot D.
Eliott D.
Threadgold G.
Harden G.
Ware D.
Begum S.
Mortimore B.
Mortimer B.
Kerry G.
Heath P.
Phillimore B.
Tracey A.
Corby N.
Dunn M.
Johnson C.
Wood J.
Clark S.
Pelan S.
Griffiths G.
Smith M.
Glithero R.
Howden P.
Barker N.
Lloyd C.
Stevens C.
Harley J.
Holt K.
Panagiotidis G.
Lovell J.
Beasley H.
Henderson C.
Gordon D.
Auger K.
Wright D.
Collins J.
Raisen C.
Dyer L.
Leung K.
Robertson L.
Ambridge K.
Leongamornlert D.
McGuire S.
Gilderthorp R.
Griffiths C.
Manthravadi D.
Nichol S.
Barker G.
Whitehead S.
Kay M.
Brown J.
Murnane C.
Gray E.
Humphries M.
Sycamore N.
Barker D.
Saunders D.
Wallis J.
Babbage A.
Hammond S.
Mashreghi-Mohammadi M.
Barr L.
Martin S.
Wray P.
Ellington A.
Matthews N.
Ellwood M.
Woodmansey R.
Clark G.
Cooper J.
Cooper J.
Tromans A.
Grafham D.
Skuce C.
Pandian R.
Andrews R.
Harrison E.
Kimberley A.
Garnett J.
Fosker N.
Hall R.
Garner P.
Kelly D.
Bird C.
Palmer S.
Gehring I.
Berger A.
Dooley C.M.
Ersan-Urun Z.
Eser C.
Geiger H.
Geisler M.
Karotki L.
Kirn A.
Konantz J.
Konantz M.
Oberlander M.
Rudolph-Geiger S.
Teucke M.
Lanz C.
Raddatz G.
Osoegawa K.
Zhu B.
Rapp A.
Widaa S.
Langford C.
Yang F.
Schuster S.C.
Carter N.P.
Harrow J.
Ning Z.
Herrero J.
Searle S.M.
Enright A.
Geisler R.
Plasterk R.H.
Lee C.
Westerfield M.
de Jong P.J.
Zon L.I.
Postlethwait J.H.
Nusslein-Volhard C.
Hubbard T.J.
Roest Crollius H.
Rogers J.
Stemple D.L.


WD repeat-containing protein 75-like protein

WD

WD

Disordered

Disordered

Disordered

Low complexity

Acidic residues

Basic and acidic residues

P:positive regulation of rRNA processing

P:positive regulation of transcription by RNA polymerase I

YVTN repeat-like/Quinoprotein amine dehydrogenase


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Stenopodainae Oncocephalus

Zdenek C.N.
Cardoso F.C.
Robinson S.D.
Mercedes R.S.
Raidjoe E.R.
Hernandez-Vargas M.J.
Jin J.
Corzo G.
Vetter I.
King G.F.
Fry B.G.
Walker A.

Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae asterids lamiids Gentianales Apocynaceae Asclepiadoideae Marsdenieae Gymnema

NB-ARC

Transcriptomic revealing of plant pathogen interaction in Gymnema sylvestre.

Helical domain of apoptotic protease-activating factors

Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

Belongs to the disease resistance NB-LRR family


Helical

Helical

Pathak J.
Thiruvengadam V.
Gracy G.R.
M M.


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Polychaeta Echiura Xenopneusta Urechidae Urechis

Heat shock protein family A member 12 variant X1

F:ATP-dependent protein folding chaperone

Belongs to the heat shock protein 70 family


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Araneae Araneomorphae Entelegynae Lycosoidea Lycosidae Pardosa

NPC intracellular cholesterol transporter 2-like protein

MD-2-related lipid-recognition


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Peiratinae Ectomocoris

Peptidase S1


Helical

Helical

Helical

Helical

K-box

F:DNA-binding transcription factor activity


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae Saxifragales Paeoniaceae Paeonia

Disordered

Disordered

Polar residues

Basic and acidic residues

Belongs to the glycosyl hydrolase 1 family


limulus clotting factor C

Peptidase S1

Selective cleavage of 103-Arg-|-Ser-104 and 124-Ile-|-Ile-125 bonds in Limulus clotting factor B to form activated factor B. Cleavage of -Pro-Arg-|-Xaa- bonds in synthetic substrates.


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Neopterygii Teleostei Neoteleostei Acanthomorphata Pelagiaria Scombriformes Stromateidae Pampus

Cystatin

Identification, molecular profiling and immune functions of cystatin M in silver pomfret (Pampus argenteus).

F:cysteine-type endopeptidase inhibitor activity


Disordered

Disordered

Disordered

Disordered

Disordered

Disordered

Disordered

Polar residues

Polar residues

Polar residues

Polar residues

Polar residues

Polar residues

Polar residues

Polar residues

Polar residues


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Noctuoidea Noctuidae Hadeninae Mythimna

Identification and sex expression profiles of olfactory-related genes in Mythimna loreyi based on antennal transcriptome analysis.

Pheromone/general odorant binding protein domain


Eukaryota Metazoa Spiralia Lophotrochozoa Brachiopoda Rhynchonelliformea Rhynchonellata Terebratellidina Laqueoidea Laqueidae Terebratalia

Helical

Dickkopf N-terminal cysteine-rich

Vellutini B.C.
Martin-Duran J.M.
Borve A.
Hejnol A.

Combinatorial Wnt signaling landscape during brachiopod anteroposterior patterning.

P:negative regulation of canonical Wnt signaling pathway

DICKKOPF N-TERMINAL CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN


Eukaryota Metazoa Porifera Demospongiae Verongimorpha Chondrillida Halisarcidae Halisarca


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Acari Acariformes Trombidiformes Prostigmata Eleutherengona Heterostigmata Tarsonemoidea Tarsonemidae Polyphagotarsonemus

Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).

Belongs to the UDP-glycosyltransferase family


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo

Initial sequencing and analysis of the human genome.

Humphray S.J.
Oliver K.
Hunt A.R.
Plumb R.W.
Loveland J.E.
Howe K.L.
Andrews T.D.
Searle S.
Hunt S.E.
Scott C.E.
Jones M.C.
Ainscough R.
Almeida J.P.
Ambrose K.D.
Ashwell R.I.
Babbage A.K.
Babbage S.
Bagguley C.L.
Bailey J.
Banerjee R.
Barker D.J.
Barlow K.F.
Bates K.
Beasley H.
Beasley O.
Bird C.P.
Bray-Allen S.
Brown A.J.
Brown J.Y.
Burford D.
Burrill W.
Burton J.
Carder C.
Carter N.P.
Chapman J.C.
Chen Y.
Clarke G.
Clark S.Y.
Clee C.M.
Clegg S.
Collier R.E.
Corby N.
Crosier M.
Cummings A.T.
Davies J.
Dhami P.
Dunn M.
Dutta I.
Dyer L.W.
Earthrowl M.E.
Faulkner L.
Fleming C.J.
Frankish A.
Frankland J.A.
French L.
Fricker D.G.
Garner P.
Garnett J.
Ghori J.
Gilbert J.G.
Glison C.
Grafham D.V.
Gribble S.
Griffiths C.
Griffiths-Jones S.
Grocock R.
Guy J.
Hall R.E.
Hammond S.
Harley J.L.
Harrison E.S.
Hart E.A.
Heath P.D.
Henderson C.D.
Hopkins B.L.
Howard P.J.
Howden P.J.
Huckle E.
Johnson C.
Johnson D.
Joy A.A.
Kay M.
Keenan S.
Kershaw J.K.
Kimberley A.M.
King A.
Knights A.
Laird G.K.
Langford C.
Lawlor S.
Leongamornlert D.A.
Leversha M.
Lloyd C.
Lloyd D.M.
Lovell J.
Martin S.
Mashreghi-Mohammadi M.
Matthews L.
McLaren S.
McLay K.E.
McMurray A.
Milne S.
Nickerson T.
Nisbett J.
Nordsiek G.
Pearce A.V.
Peck A.I.
Porter K.M.
Pandian R.
Pelan S.
Phillimore B.
Povey S.
Ramsey Y.
Rand V.
Scharfe M.
Sehra H.K.
Shownkeen R.
Sims S.K.
Skuce C.D.
Smith M.
Steward C.A.
Swarbreck D.
Sycamore N.
Tester J.
Thorpe A.
Tracey A.
Tromans A.
Thomas D.W.
Wall M.
Wallis J.M.
West A.P.
Whitehead S.L.
Willey D.L.
Williams S.A.
Wilming L.
Wray P.W.
Young L.
Ashurst J.L.
Coulson A.
Blocker H.
Durbin R.
Sulston J.E.
Hubbard T.
Jackson M.J.
Bentley D.R.
Beck S.
Rogers J.
Dunham I.

DNA sequence and analysis of human chromosome 9.

Finishing the euchromatic sequence of the human genome.


Helical

Helical

Helical

Helical

Helical

Helical

Helical

Helical

Helical

Helical

Helical

Helical

Helical

Helical

Helical

Helical

Chitin synthase chs-1/2 N-terminal putative transporter

Disordered

Disordered

Disordered

Polar residues

Polar residues

Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A

[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)

Belongs to the chitin synthase family. Class IV subfamily


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Amphibia Batrachia Anura Neobatrachia Ranoidea Ranidae Nidirana

Zheng P.
Gong Y.
Wang B.
Yu H.
Huang S.
Liao X.
Jiang J.
Ran J.
Xie F.

Love Hug-Functional Validation of Nuptial Pad-Secreted Pheromone in Anurans.


Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Bivalvia Autobranchia Pteriomorphia Pterioida Pterioidea Pteriidae Pinctada

Helical

Helical

Helical

Helical

Helical

Helical

Helical

Disordered

Basic residues

F:G protein-coupled peptide receptor activity

Rhodopsin 7-helix transmembrane proteins

G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN

Family A G protein-coupled receptor-like

Belongs to the G-protein coupled receptor 1 family


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Neopterygii Teleostei Clupei Clupeiformes Clupeoidei Clupeidae Tenualosa

Glycoprotein hormone subunit beta

Pathan M.A.
Dasgupta S.
Tripathi G.
Mitra P.
Misra A.
Pandey A.

Complete gene characterization of gonadotrophins in Tenualosa ilisha.


Heat shock protein family A member 12 variant X3

F:ATP-dependent protein folding chaperone

Belongs to the heat shock protein 70 family


Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Gastropoda Caenogastropoda Neogastropoda Buccinoidea Buccinidae Colubraria

VWFA

Modica M.V.
Gerdol M.
Fracarossi D.
Cervelli M.
Reinoso Sanchez J.F.
Leone S.
Tartaglia G.
Milanetti E.
Vassalli Q.A.
Ruggeri Z.M.
Oliverio M.

A vampire's tale: a novel family of anti-platelet proteins from the marine snail Cumia reticulata.


Helical

EGF-like

P:calcium ion import across plasma membrane

Lacks conserved residue(s) required for the propagation of feature annotation


Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Cephalopoda Coleoidea Octopodiformes Octopoda Incirrata Octopodidae Callistoctopus

Biopterin-dependent aromatic amino acid hydroxylase family profile

Aromatic aminoacid monoxygenases, catalytic and oligomerization domains

Belongs to the biopterin-dependent aromatic amino acid hydroxylase family


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Clitellata Oligochaeta Enchytraeida Enchytraeidae Enchytraeus

PAZ

Piwi

Disordered

Low complexity

P:regulatory ncRNA-mediated gene silencing

Ribonuclease H-like superfamily/Ribonuclease H

EUKARYOTIC TRANSLATION INITIATION FACTOR 2C

Belongs to the argonaute family. Piwi subfamily


DOMON

Disordered

Disordered

Disordered

Disordered

Disordered

Polar residues

Low complexity

Low complexity

Low complexity

Low complexity

Polar residues

Low complexity


Disordered

Low complexity

Fernando A.
Liyanage C.
Moradi A.
Janaththani P.
Batra J.

Identification and Characterization of Alternatively Spliced Transcript Isoforms of IRX4 in Prostate Cancer.


Eukaryota Metazoa Hemichordata Pterobranchia Cephalodiscida Cephalodiscidae Cephalodiscus

BHLH

PAS

PAS

Disordered

Belato F.A.
Mello B.
Coates C.J.
Halanych K.M.
Brown F.D.
Morandini A.C.
Leme J.M.
Trindade R.I.F.
Costa-Paiva E.M.

Divergence time estimates for the hypoxia-inducible factor-1 alpha (HIF1a) reveal an ancient emergence of animals in low-oxygen environments.

F:DNA-binding transcription factor activity, RNA polymerase II-specific

F:RNA polymerase II transcription regulatory region sequence-specific DNA binding

HLH, helix-loop-helix DNA-binding domain


VWFA

VWFA

Disordered

Low complexity


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Glires Rodentia Myomorpha Muroidea Muridae Murinae Mus Mus

Disordered

Church D.M.
Goodstadt L.
Hillier L.W.
Zody M.C.
Goldstein S.
She X.
Bult C.J.
Agarwala R.
Cherry J.L.
DiCuccio M.
Hlavina W.
Kapustin Y.
Meric P.
Maglott D.
Birtle Z.
Marques A.C.
Graves T.
Zhou S.
Teague B.
Potamousis K.
Churas C.
Place M.
Herschleb J.
Runnheim R.
Forrest D.
Amos-Landgraf J.
Schwartz D.C.
Cheng Z.
Lindblad-Toh K.
Eichler E.E.
Ponting C.P.

Church D.M.
Schneider V.A.
Graves T.
Auger K.
Cunningham F.
Bouk N.
Chen H.C.
Agarwala R.
McLaren W.M.
Ritchie G.R.
Albracht D.
Kremitzki M.
Rock S.
Kotkiewicz H.
Kremitzki C.
Wollam A.
Trani L.
Fulton L.
Fulton R.
Matthews L.
Whitehead S.
Chow W.
Torrance J.
Dunn M.
Harden G.
Threadgold G.
Wood J.
Collins J.
Heath P.
Griffiths G.
Pelan S.
Grafham D.
Eichler E.E.
Weinstock G.
Mardis E.R.
Wilson R.K.
Howe K.
Flicek P.
Hubbard T.


Heterogeneous nuclear ribonucleoprotein H1


VWFA


Eukaryota Metazoa Spiralia Lophotrochozoa Bryozoa Phylactolaemata Pectinatellidae Pectinatella

PAS

PAS

Hypoxia-inducible factor 1-alpha isoform 1


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Leucinodes

Odorant binding protein/PBP-general odorant binding protein

Pheromone/general odorant binding protein domain


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Peiratinae Ectomocoris


Disordered

Lander E.S.
Linton L.M.
Birren B.
Nusbaum C.
Zody M.C.
Baldwin J.
Devon K.
Dewar K.
Doyle M.
FitzHugh W.
Funke R.
Gage D.
Harris K.
Heaford A.
Howland J.
Kann L.
Lehoczky J.
LeVine R.
McEwan P.
McKernan K.
Meldrim J.
Mesirov J.P.
Miranda C.
Morris W.
Naylor J.
Raymond C.
Rosetti M.
Santos R.
Sheridan A.
Sougnez C.
Stange-Thomann N.
Stojanovic N.
Subramanian A.
Wyman D.
Rogers J.
Sulston J.
Ainscough R.
Beck S.
Bentley D.
Burton J.
Clee C.
Carter N.
Coulson A.
Deadman R.
Deloukas P.
Dunham A.
Dunham I.
Durbin R.
French L.
Grafham D.
Gregory S.
Hubbard T.
Humphray S.
Hunt A.
Jones M.
Lloyd C.
McMurray A.
Matthews L.
Mercer S.
Milne S.
Mullikin J.C.
Mungall A.
Plumb R.
Ross M.
Shownkeen R.
Sims S.
Waterston R.H.
Wilson R.K.
Hillier L.W.
McPherson J.D.
Marra M.A.
Mardis E.R.
Fulton L.A.
Chinwalla A.T.
Pepin K.H.
Gish W.R.
Chissoe S.L.
Wendl M.C.
Delehaunty K.D.
Miner T.L.
Delehaunty A.
Kramer J.B.
Cook L.L.
Fulton R.S.
Johnson D.L.
Minx P.J.
Clifton S.W.
Hawkins T.
Branscomb E.
Predki P.
Richardson P.
Wenning S.
Slezak T.
Doggett N.
Cheng J.F.
Olsen A.
Lucas S.
Elkin C.
Uberbacher E.
Frazier M.
Gibbs R.A.
Muzny D.M.
Scherer S.E.
Bouck J.B.
Sodergren E.J.
Worley K.C.
Rives C.M.
Gorrell J.H.
Metzker M.L.
Naylor S.L.
Kucherlapati R.S.
Nelson D.L.
Weinstock G.M.
Sakaki Y.
Fujiyama A.
Hattori M.
Yada T.
Toyoda A.
Itoh T.
Kawagoe C.
Watanabe H.
Totoki Y.
Taylor T.
Weissenbach J.
Heilig R.
Saurin W.
Artiguenave F.
Brottier P.
Bruls T.
Pelletier E.
Robert C.
Wincker P.
Smith D.R.
Doucette-Stamm L.
Rubenfield M.
Weinstock K.
Lee H.M.
Dubois J.
Rosenthal A.
Platzer M.
Nyakatura G.
Taudien S.
Rump A.
Yang H.
Yu J.
Wang J.
Huang G.
Gu J.
Hood L.
Rowen L.
Madan A.
Qin S.
Davis R.W.
Federspiel N.A.
Abola A.P.
Proctor M.J.
Myers R.M.
Schmutz J.
Dickson M.
Grimwood J.
Cox D.R.
Olson M.V.
Kaul R.
Raymond C.
Shimizu N.
Kawasaki K.
Minoshima S.
Evans G.A.
Athanasiou M.
Schultz R.
Roe B.A.
Chen F.
Pan H.
Ramser J.
Lehrach H.
Reinhardt R.
McCombie W.R.
de la Bastide M.
Dedhia N.
Blocker H.
Hornischer K.
Nordsiek G.
Agarwala R.
Aravind L.
Bailey J.A.
Bateman A.
Batzoglou S.
Birney E.
Bork P.
Brown D.G.
Burge C.B.
Cerutti L.
Chen H.C.
Church D.
Clamp M.
Copley R.R.
Doerks T.
Eddy S.R.
Eichler E.E.
Furey T.S.
Galagan J.
Gilbert J.G.
Harmon C.
Hayashizaki Y.
Haussler D.
Hermjakob H.
Hokamp K.
Jang W.
Johnson L.S.
Jones T.A.
Kasif S.
Kaspryzk A.
Kennedy S.
Kent W.J.
Kitts P.
Koonin E.V.
Korf I.
Kulp D.
Lancet D.
Lowe T.M.
McLysaght A.
Mikkelsen T.
Moran J.V.
Mulder N.
Pollara V.J.
Ponting C.P.
Schuler G.
Schultz J.
Slater G.
Smit A.F.
Stupka E.
Szustakowski J.
Thierry-Mieg D.
Thierry-Mieg J.
Wagner L.
Wallis J.
Wheeler R.
Williams A.
Wolf Y.I.
Wolfe K.H.
Yang S.P.
Yeh R.F.
Collins F.
Guyer M.S.
Peterson J.
Felsenfeld A.
Wetterstrand K.A.
Patrinos A.
Morgan M.J.
de Jong P.
Catanese J.J.
Osoegawa K.
Shizuya H.
Choi S.
Chen Y.J.

Cole C.G.
McCann O.T.
Collins J.E.
Oliver K.
Willey D.
Gribble S.M.
Yang F.
McLaren K.
Rogers J.
Ning Z.
Beare D.M.
Dunham I.

Finishing the finished human chromosome 22 sequence.


Helical

Helical

Helical

Helical


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae rosids fabids Rosales Elaeagnaceae Hippophae

MADS-box

Zhao J.
Xu Y.
Zhang Z.
Zhao M.
Li K.
Wang F.
Sun K.

Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.

F:RNA polymerase II cis-regulatory region sequence-specific DNA binding

P:positive regulation of transcription by RNA polymerase II


Bacteria Bacillati Cyanobacteriota Cyanophyceae Gloeobacterales Anthocerotibacteraceae Anthocerotibacter

PBS-linker

PBS-linker

PBS-linker

PBS-linker

PBS-linker

Jiang H.W.
Wu H.Y.
Wang C.H.
Yang C.H.
Ko J.T.
Ho H.C.
Tsai M.D.
Bryant D.A.
Li F.W.
Ho M.C.
Ho M.Y.

A structure of the relict phycobilisome from a thylakoid-free cyanobacterium.

STRUCTURE BY ELECTRON MICROSCOPY (3.07 ANGSTROMS)

C:plasma membrane-derived thylakoid membrane

PHYCOBILISOME 32.1 KDA LINKER POLYPEPTIDE, PHYCOCYANIN-ASSOCIATED, ROD 2-RELATED

Belongs to the phycobilisome linker protein family


Helical

Fibronectin type-III

Fibronectin type-III

Fibronectin type-III

Fibronectin type-III

Fibronectin type-III

Fibronectin type-III

Fibronectin type-III

Fibronectin type-III

Fibronectin type-III

Fibronectin type-III

Fibronectin type-III

Fibronectin type-III

Fibronectin type-III

FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Pleocyemata Brachyura Eubrachyura Potamoidea Potamidae Tenuipotamon

Shi B.Y.
Pan D.
Zhang K.Q.
Gu T.Y.
Yeo D.C.J.
Ng P.K.L.
Cumberlidge N.
Sun H.Y.

Diversification of freshwater crabs on the sky islands in the Hengduan Mountains Region, China.


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Polychaeta Echiura Xenopneusta Urechidae Urechis

Heat shock protein family A member 12 variant X4

F:ATP-dependent protein folding chaperone

Belongs to the heat shock protein 70 family


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Acari Acariformes Trombidiformes Prostigmata Eleutherengona Heterostigmata Tarsonemoidea Tarsonemidae Polyphagotarsonemus

Glycosyl transferase family 28 C-terminal


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Neopterygii Teleostei Ostariophysi Cypriniformes Danionidae Danioninae Danio

Helical

Helical

Helical

Helical

Amine oxidase

Howe K.
Clark M.D.
Torroja C.F.
Torrance J.
Berthelot C.
Muffato M.
Collins J.E.
Humphray S.
McLaren K.
Matthews L.
McLaren S.
Sealy I.
Caccamo M.
Churcher C.
Scott C.
Barrett J.C.
Koch R.
Rauch G.J.
White S.
Chow W.
Kilian B.
Quintais L.T.
Guerra-Assuncao J.A.
Zhou Y.
Gu Y.
Yen J.
Vogel J.H.
Eyre T.
Redmond S.
Banerjee R.
Chi J.
Fu B.
Langley E.
Maguire S.F.
Laird G.K.
Lloyd D.
Kenyon E.
Donaldson S.
Sehra H.
Almeida-King J.
Loveland J.
Trevanion S.
Jones M.
Quail M.
Willey D.
Hunt A.
Burton J.
Sims S.
McLay K.
Plumb B.
Davis J.
Clee C.
Oliver K.
Clark R.
Riddle C.
Elliot D.
Eliott D.
Threadgold G.
Harden G.
Ware D.
Begum S.
Mortimore B.
Mortimer B.
Kerry G.
Heath P.
Phillimore B.
Tracey A.
Corby N.
Dunn M.
Johnson C.
Wood J.
Clark S.
Pelan S.
Griffiths G.
Smith M.
Glithero R.
Howden P.
Barker N.
Lloyd C.
Stevens C.
Harley J.
Holt K.
Panagiotidis G.
Lovell J.
Beasley H.
Henderson C.
Gordon D.
Auger K.
Wright D.
Collins J.
Raisen C.
Dyer L.
Leung K.
Robertson L.
Ambridge K.
Leongamornlert D.
McGuire S.
Gilderthorp R.
Griffiths C.
Manthravadi D.
Nichol S.
Barker G.
Whitehead S.
Kay M.
Brown J.
Murnane C.
Gray E.
Humphries M.
Sycamore N.
Barker D.
Saunders D.
Wallis J.
Babbage A.
Hammond S.
Mashreghi-Mohammadi M.
Barr L.
Martin S.
Wray P.
Ellington A.
Matthews N.
Ellwood M.
Woodmansey R.
Clark G.
Cooper J.
Cooper J.
Tromans A.
Grafham D.
Skuce C.
Pandian R.
Andrews R.
Harrison E.
Kimberley A.
Garnett J.
Fosker N.
Hall R.
Garner P.
Kelly D.
Bird C.
Palmer S.
Gehring I.
Berger A.
Dooley C.M.
Ersan-Urun Z.
Eser C.
Geiger H.
Geisler M.
Karotki L.
Kirn A.
Konantz J.
Konantz M.
Oberlander M.
Rudolph-Geiger S.
Teucke M.
Lanz C.
Raddatz G.
Osoegawa K.
Zhu B.
Rapp A.
Widaa S.
Langford C.
Yang F.
Schuster S.C.
Carter N.P.
Harrow J.
Ning Z.
Herrero J.
Searle S.M.
Enright A.
Geisler R.
Plasterk R.H.
Lee C.
Westerfield M.
de Jong P.J.
Zon L.I.
Postlethwait J.H.
Nusslein-Volhard C.
Hubbard T.J.
Roest Crollius H.
Rogers J.
Stemple D.L.

The zebrafish reference genome sequence and its relationship to the human genome.

FAD-linked reductases, C-terminal domain


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Actinopterygii Neopterygii Teleostei Protacanthopterygii Salmoniformes Salmonidae Salmoninae Salmo

Apoptosis-associated speck-like protein containing a CARD

CARD

Disordered

Polar residues

Acevedo-Castillo W.A.
Moran-Figueroa R.
Vargas-Chacoff L.
Morera F.J.
Pontigo J.P.

Revealing the Salmo salar NLRP3 Inflammasome: Insights from Structural Modeling and Transcriptome Analysis.

APOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN CONTAINING A CARD

NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1


Eukaryota Metazoa Porifera Demospongiae Verongimorpha Chondrillida Halisarcidae Halisarca

Disordered

Low complexity

Basic and acidic residues

Belongs to the glycosyltransferase 31 family


Ligated ion channel binding I - glutamate

Helical

Helical

Helical

Helical


Helical

Ig-like

Fibronectin type-III

Disordered

Disordered

Disordered

Low complexity

Basic and acidic residues

Basic residues

Basic and acidic residues

Low complexity


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae asterids lamiids Lamiales Oleaceae Oleeae Syringa

Terpene synthase N-terminal

Terpene synthase metal-binding

Trichome birefringence-like N-terminal

Trichome birefringence-like C-terminal

Secondary metabolite biosynthesis; terpenoid biosynthesis

Belongs to the PC-esterase family. TBL subfamily


Helical

Helical

Helical

TLC

Lipid metabolism; sphingolipid metabolism


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida Magnoliidae Piperales Asaraceae Asarum

Helical

axial binding residue

F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Helical

Peptidase metallopeptidase

Hemopexin

Hemopexin

Hemopexin

Hemopexin

Disordered

Pro residues

Phosphotyrosine; by PKDCC

Accumulation of soxC-expressing cells facilitated by MMPreg in the blastema formation in annelid Enchytraeus japonensis.

MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED

Metalloproteases ('zincins'), catalytic domain

Can bind about 5 Ca(2+) ions per subunit.


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Stenopodainae Oncocephalus

CUB

Zdenek C.N.
Cardoso F.C.
Robinson S.D.
Mercedes R.S.
Raidjoe E.R.
Hernandez-Vargas M.J.
Jin J.
Corzo G.
Vetter I.
King G.F.
Fry B.G.
Walker A.

Venom adaptation and exaptation during the trophic switch to blood-feeding by kissing bugs (Reduviidae: Triatominae).

Lacks conserved residue(s) required for the propagation of feature annotation


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Sternorrhyncha Coccoidea Pseudococcidae Maconellicoccus

Helical

axial binding residue

Selvamani S.B.
Negi N.
Nagarjuna Reddy K.V.
Ramasamy G.G.

Identification of Cytochrome P450s in Maconellicoccus hirsutus.


Eukaryota Sar Alveolata Dinophyceae Gonyaulacales Lingulodiniaceae Lingulodinium

Helical

Helical

Helical

Helical

Helical

Helical

Helical

Disordered

Polar residues

Knockdown of Dinoflagellate Cellulose Synthase CesA1 Resulted in Malformed Intracellular Cellulosic Thecal Plates and Severely Impeded Cyst-to-Swarmer Transition.

Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A

CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]


Helical

Helical

Helical

Helical

Helical

Helical

Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).

F:G protein-coupled serotonin receptor activity

P:adenylate cyclase-activating adrenergic receptor signaling pathway

Rhodopsin 7-helix transmembrane proteins

ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR

Family A G protein-coupled receptor-like

Belongs to the G-protein coupled receptor 1 family


Belongs to the UDP-glycosyltransferase family


Helical

axial binding residue


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Polyneoptera Orthoptera Caelifera Acrididea Acridomorpha Acridoidea Acrididae Oedipodinae Locusta

Tudor

Tudor

Tudor

Tudor

Tudor

Tudor

Tudor

Tudor

Disordered

Polar residues

Basic and acidic residues

Basic and acidic residues

Basic and acidic residues

Basic and acidic residues

Basic and acidic residues

Polar residues

Basic and acidic residues

Polar residues

Identification and Expression Profile Analysis of Tudor Family Genes in Locusta migratoria, and Functional Characterization of LmTdr7.


Eukaryota Discoba Euglenozoa Kinetoplastea Metakinetoplastina Trypanosomatida Trypanosomatidae Blastocrithidia

Helical

Helical

Helical

Helical

Helical

Helical

Helical

Heme-copper oxidase subunit III family profile

Cytochrome c oxidase, subunit III, four-helix bundle

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix

Belongs to the cytochrome c oxidase subunit 3 family


Epithelial sodium channel/degenerin-like protein

Helical

Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Polychaeta Sedentaria Canalipalpata Terebellida Terebelliformia Trichobranchidae Terebellides

BHLH

PAS

PAS

Disordered

Disordered

Basic residues

Basic and acidic residues

F:DNA-binding transcription factor activity, RNA polymerase II-specific

F:RNA polymerase II transcription regulatory region sequence-specific DNA binding

Hypoxia-inducible factor 1 subunit alpha

Hypoxia-inducible factor 1-alpha isoform 1

HLH, helix-loop-helix DNA-binding domain


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Polychaeta Sedentaria Canalipalpata Sabellida Siboglinidae Osedax

Helical

Helical

Helical

Helical

Helical

Helical

Disordered

Disordered

Disordered

Polar residues

Basic and acidic residues

Gly residues

Tilic E.
Miyamoto N.
Herranz M.
Worsaae K.

Hooked on zombie worms? Genetic blueprints of bristle formation in Osedax japonicus (Annelida).


F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


Helical

Helical

Helical

Helical

Disordered

F:acetylcholine-gated monoatomic cation-selective channel activity

F:transmembrane signaling receptor activity

Acetylcholine receptor subunit alpha-like

Neurotransmitter-gated ion-channel ligand-binding domain

Neurotransmitter-gated ion-channel transmembrane domain

Neurotransmitter-gated ion-channel transmembrane pore

Nicotinic receptor ligand binding domain-like

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Pyraloidea Crambidae Spilomelinae Leucinodes

Helical

Helical

Helical

Pathak J.
Thiruvengadam V.
Gracy G.R.
M M.


Receptor-type tyrosine-protein phosphatase-like protein

Helical

Fibronectin type-III

Fibronectin type-III

Fibronectin type-III

Fibronectin type-III

Tyrosine-protein phosphatase

Tyrosine specific protein phosphatases

Tyrosine-protein phosphatase

Tyrosine specific protein phosphatases

Disordered

Polar residues

Protein tyrosine phosphatase superfamily

(Phosphotyrosine protein) phosphatases II

O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Zygaenoidea Limacodidae Comana

Goudarzi M.H.
Robinson S.D.
Cardoso F.C.
Mitchell M.L.
Cook L.G.
King G.F.
Walker A.A.

Phylogeny, envenomation syndrome, and membrane-permeabilising venom produced by Australia's 'electric' caterpillar Comana monomorpha (Lepidoptera: Limacodidae).

F:transmembrane receptor protein tyrosine kinase activator activity

Lacks conserved residue(s) required for the propagation of feature annotation


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Lepidoptera Glossata Ditrysia Zygaenoidea Megalopygidae Megalopyge

Walker A.A.
Robinson S.D.
Merritt D.J.
Cardoso F.C.
Goudarzi M.H.
Mercedes R.S.
Eagles D.A.
Cooper P.
Zdenek C.N.
Fry B.G.
Hall D.W.
Vetter I.
King G.F.

Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae).

NUCLEOTIDE SEQUENCE [MRNA]
MASS SPECTROMETRY
SYNTHESIS OF 30-40
SUBCELLULAR LOCATION
TISSUE SPECIFICITY
DEVELOPMENTAL STAGE


Eukaryota Metazoa Ecdysozoa Arthropoda Hexapoda Insecta Pterygota Neoptera Paraneoptera Hemiptera Heteroptera Panheteroptera Cimicomorpha Reduviidae Peiratinae Ectomocoris


Jacalin-type lectin

Jacalin-type lectin

PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN DWY1, CHLOROPLASTIC


Disordered

6-Phosphogluconate Dehydrogenase, domain 3


Tubulin/FtsZ GTPase

Disordered

Initial sequencing and analysis of the human genome.

Grimwood J.
Gordon L.A.
Olsen A.
Terry A.
Schmutz J.
Lamerdin J.
Hellsten U.
Goodstein D.
Couronne O.
Tran-Gyamfi M.
Aerts A.
Altherr M.
Ashworth L.
Bajorek E.
Black S.
Branscomb E.
Caenepeel S.
Carrano A.
Caoile C.
Chan Y.M.
Christensen M.
Cleland C.A.
Copeland A.
Dalin E.
Dehal P.
Denys M.
Detter J.C.
Escobar J.
Flowers D.
Fotopulos D.
Garcia C.
Georgescu A.M.
Glavina T.
Gomez M.
Gonzales E.
Groza M.
Hammon N.
Hawkins T.
Haydu L.
Ho I.
Huang W.
Israni S.
Jett J.
Kadner K.
Kimball H.
Kobayashi A.
Larionov V.
Leem S.H.
Lopez F.
Lou Y.
Lowry S.
Malfatti S.
Martinez D.
McCready P.
Medina C.
Morgan J.
Nelson K.
Nolan M.
Ovcharenko I.
Pitluck S.
Pollard M.
Popkie A.P.
Predki P.
Quan G.
Ramirez L.
Rash S.
Retterer J.
Rodriguez A.
Rogers S.
Salamov A.
Salazar A.
She X.
Smith D.
Slezak T.
Solovyev V.
Thayer N.
Tice H.
Tsai M.
Ustaszewska A.
Vo N.
Wagner M.
Wheeler J.
Wu K.
Xie G.
Yang J.
Dubchak I.
Furey T.S.
DeJong P.
Dickson M.
Gordon D.
Eichler E.E.
Pennacchio L.A.
Richardson P.
Stubbs L.
Rokhsar D.S.
Myers R.M.
Rubin E.M.
Lucas S.M.

The DNA sequence and biology of human chromosome 19.

Finishing the euchromatic sequence of the human genome.


Eukaryota Metazoa Spiralia Lophotrochozoa Annelida Polychaeta Echiura Xenopneusta Urechidae Urechis

Fork-head

Fork-head

Disordered

Disordered

Disordered

Disordered

Disordered

Polar residues

Basic and acidic residues

Low complexity

Low complexity

Low complexity

Polar residues

Low complexity

Polar residues

F:DNA-binding transcription factor activity, RNA polymerase II-specific

F:RNA polymerase II cis-regulatory region sequence-specific DNA binding

Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain


Helical

Helical


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Amphibia Batrachia Anura Neobatrachia Ranoidea Ranidae Nidirana

Zheng P.
Gong Y.
Wang B.
Yu H.
Huang S.
Liao X.
Jiang J.
Ran J.
Xie F.

Love Hug-Functional Validation of Nuptial Pad-Secreted Pheromone in Anurans.


Eukaryota Metazoa Spiralia Lophotrochozoa Mollusca Gastropoda Caenogastropoda Neogastropoda Buccinoidea Buccinidae Colubraria

VWFA

Modica M.V.
Gerdol M.
Fracarossi D.
Cervelli M.
Reinoso Sanchez J.F.
Leone S.
Tartaglia G.
Milanetti E.
Vassalli Q.A.
Ruggeri Z.M.
Oliverio M.

A vampire's tale: a novel family of anti-platelet proteins from the marine snail Cumia reticulata.


Eukaryota Metazoa Ecdysozoa Arthropoda Crustacea Multicrustacea Malacostraca Eumalacostraca Eucarida Decapoda Pleocyemata Caridea Palaemonoidea Palaemonidae Macrobrachium

Fork-head

Fork-head

Disordered

Disordered

Disordered

Disordered

Basic and acidic residues

Gly residues

Low complexity

F:DNA-binding transcription activator activity, RNA polymerase II-specific

P:negative regulation of multicellular organism growth

P:positive regulation of catabolic process

P:positive regulation of defense response

P:positive regulation of immune response


Eukaryota
Viridiplantae
Streptophyta
Embryophyta
Tracheophyta
Spermatophyta
Magnoliopsida
eudicotyledons
Gunneridae
Pentapetalae
rosids
malvids
Myrtales
Myrtaceae
Myrtoideae
Myrteae
Pimenta group
Psidium

Terpene synthase N-terminal

Terpene synthase metal-binding

Canal D.
dos Santos P.H.D.
Carpinetti-Oliveira P.A.
Silva M.A.
Fernandes M.
Brustolini O.J.B.
Ferreira A.
Ferreira M.F.S.

Comparative genome-wide analysis of two guava cultivars revels plasticity of sesquiterpene biosynthesis.


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Bovinae Bos

Rosen B.D.
Bickhart D.M.
Koren S.
Schnabel R.D.
Hall R.
Zimin A.
Dreischer C.
Schultheiss S.
Schroeder S.G.
Elsik C.G.
Couldrey C.
Liu G.E.
Van Tassell C.P.
Phillippy A.M.
Smith T.P.L.
Medrano J.F.

ARS-UCD1.2.


Eukaryota Sar Stramenopiles Bigyra Labyrinthulomycetes Thraustochytrida Thraustochytriidae Schizochytrium

MRH

Disordered

Disordered

Low complexity

Polar residues

Basic and acidic residues

Acidic residues

Low complexity

Metabolism balance regulation for squalene production by disturbing triglycerides (TAG) synthesis in Schizochytrium sp.

P:endoplasmic reticulum unfolded protein response

P:retrograde protein transport, ER to cytosol

Mannose-6-phosphate receptor binding domain


Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliopsida eudicotyledons Gunneridae Pentapetalae rosids fabids Rosales Elaeagnaceae Hippophae

MADS-box

Disordered

Basic residues

Genome-wide analysis of the MADS-box gene family of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and their potential role in floral organ development.


Eukaryota Metazoa Porifera Demospongiae Heteroscleromorpha Poecilosclerida Hymedesmiidae Kirkpatrickia

Disordered

Disordered

Low complexity

Low complexity

Belato F.A.
Mello B.
Coates C.J.
Halanych K.M.
Brown F.D.
Morandini A.C.
Leme J.M.
Trindade R.I.F.
Costa-Paiva E.M.

Divergence time estimates for the hypoxia-inducible factor-1 alpha (HIF1a) reveal an ancient emergence of animals in low-oxygen environments.

F:RNA polymerase II transcription regulatory region sequence-specific DNA binding


Protein kinase

Disordered

Qin Z.
Yang J.
Zhang K.
Gao X.
Ran Q.
Xu Y.
Wang Z.
Lou D.
Huang C.
Zellmer L.
Meng G.
Chen N.
Ma H.
Wang Z.
Liao D.J.

Updating mRNA variants of the human RSK4 gene and their expression in different stressed situations.

Qin Z.W.
Yang J.L.
Zhang K.Y.
Gao X.
Ran Q.C.
Xu Y.H.
Wang Z.
Lou D.D.
Huang C.H.
Zellmer L.
Meng G.X.
Chen N.
Ma H.
Wang Z.
Liao D.J.

F:protein serine/threonine kinase activity

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Glires Rodentia Myomorpha Muroidea Muridae Murinae Mus Mus

Carboxylesterase type B

Disordered

Basic and acidic residues

Church D.M.
Goodstadt L.
Hillier L.W.
Zody M.C.
Goldstein S.
She X.
Bult C.J.
Agarwala R.
Cherry J.L.
DiCuccio M.
Hlavina W.
Kapustin Y.
Meric P.
Maglott D.
Birtle Z.
Marques A.C.
Graves T.
Zhou S.
Teague B.
Potamousis K.
Churas C.
Place M.
Herschleb J.
Runnheim R.
Forrest D.
Amos-Landgraf J.
Schwartz D.C.
Cheng Z.
Lindblad-Toh K.
Eichler E.E.
Ponting C.P.

Lineage-specific biology revealed by a finished genome assembly of the mouse.

Church D.M.
Schneider V.A.
Graves T.
Auger K.
Cunningham F.
Bouk N.
Chen H.C.
Agarwala R.
McLaren W.M.
Ritchie G.R.
Albracht D.
Kremitzki M.
Rock S.
Kotkiewicz H.
Kremitzki C.
Wollam A.
Trani L.
Fulton L.
Fulton R.
Matthews L.
Whitehead S.
Chow W.
Torrance J.
Dunn M.
Harden G.
Threadgold G.
Wood J.
Collins J.
Heath P.
Griffiths G.
Pelan S.
Grafham D.
Eichler E.E.
Weinstock G.
Mardis E.R.
Wilson R.K.
Howe K.
Flicek P.
Hubbard T.

Modernizing reference genome assemblies.

Belongs to the type-B carboxylesterase/lipase family


Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo

ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase


Eukaryota
Viridiplantae
Streptophyta
Embryophyta
Tracheophyta
Spermatophyta
Magnoliopsida
eudicotyledons
Gunneridae
Pentapetalae
rosids
fabids
Fabales
Fabaceae
Papilionoideae
50 kb inversion clade
NPAAA clade
indigoferoid/millettioid clade
Millettieae
Pongamia

Disordered

Polar residues

Transcripts identified in leaf tissues of Pongamia pinnata at the University of Delhi, India.


Helical

Disordered

Polar residues

Lander E.S.
Linton L.M.
Birren B.
Nusbaum C.
Zody M.C.
Baldwin J.
Devon K.
Dewar K.
Doyle M.
FitzHugh W.
Funke R.
Gage D.
Harris K.
Heaford A.
Howland J.
Kann L.
Lehoczky J.
LeVine R.
McEwan P.
McKernan K.
Meldrim J.
Mesirov J.P.
Miranda C.
Morris W.
Naylor J.
Raymond C.
Rosetti M.
Santos R.
Sheridan A.
Sougnez C.
Stange-Thomann N.
Stojanovic N.
Subramanian A.
Wyman D.
Rogers J.
Sulston J.
Ainscough R.
Beck S.
Bentley D.
Burton J.
Clee C.
Carter N.
Coulson A.
Deadman R.
Deloukas P.
Dunham A.
Dunham I.
Durbin R.
French L.
Grafham D.
Gregory S.
Hubbard T.
Humphray S.
Hunt A.
Jones M.
Lloyd C.
McMurray A.
Matthews L.
Mercer S.
Milne S.
Mullikin J.C.
Mungall A.
Plumb R.
Ross M.
Shownkeen R.
Sims S.
Waterston R.H.
Wilson R.K.
Hillier L.W.
McPherson J.D.
Marra M.A.
Mardis E.R.
Fulton L.A.
Chinwalla A.T.
Pepin K.H.
Gish W.R.
Chissoe S.L.
Wendl M.C.
Delehaunty K.D.
Miner T.L.
Delehaunty A.
Kramer J.B.
Cook L.L.
Fulton R.S.
Johnson D.L.
Minx P.J.
Clifton S.W.
Hawkins T.
Branscomb E.
Predki P.
Richardson P.
Wenning S.
Slezak T.
Doggett N.
Cheng J.F.
Olsen A.
Lucas S.
Elkin C.
Uberbacher E.
Frazier M.
Gibbs R.A.
Muzny D.M.
Scherer S.E.
Bouck J.B.
Sodergren E.J.
Worley K.C.
Rives C.M.
Gorrell J.H.
Metzker M.L.
Naylor S.L.
Kucherlapati R.S.
Nelson D.L.
Weinstock G.M.
Sakaki Y.
Fujiyama A.
Hattori M.
Yada T.
Toyoda A.
Itoh T.
Kawagoe C.
Watanabe H.
Totoki Y.
Taylor T.
Weissenbach J.
Heilig R.
Saurin W.
Artiguenave F.
Brottier P.
Bruls T.
Pelletier E.
Robert C.
Wincker P.
Smith D.R.
Doucette-Stamm L.
Rubenfield M.
Weinstock K.
Lee H.M.
Dubois J.
Rosenthal A.
Platzer M.
Nyakatura G.
Taudien S.
Rump A.
Yang H.
Yu J.
Wang J.
Huang G.
Gu J.
Hood L.
Rowen L.
Madan A.
Qin S.
Davis R.W.
Federspiel N.A.
Abola A.P.
Proctor M.J.
Myers R.M.
Schmutz J.
Dickson M.
Grimwood J.
Cox D.R.
Olson M.V.
Kaul R.
Raymond C.
Shimizu N.
Kawasaki K.
Minoshima S.
Evans G.A.
Athanasiou M.
Schultz R.
Roe B.A.
Chen F.
Pan H.
Ramser J.
Lehrach H.
Reinhardt R.
McCombie W.R.
de la Bastide M.
Dedhia N.
Blocker H.
Hornischer K.
Nordsiek G.
Agarwala R.
Aravind L.
Bailey J.A.
Bateman A.
Batzoglou S.
Birney E.
Bork P.
Brown D.G.
Burge C.B.
Cerutti L.
Chen H.C.
Church D.
Clamp M.
Copley R.R.
Doerks T.
Eddy S.R.
Eichler E.E.
Furey T.S.
Galagan J.
Gilbert J.G.
Harmon C.
Hayashizaki Y.
Haussler D.
Hermjakob H.
Hokamp K.
Jang W.
Johnson L.S.
Jones T.A.
Kasif S.
Kaspryzk A.
Kennedy S.
Kent W.J.
Kitts P.
Koonin E.V.
Korf I.
Kulp D.
Lancet D.
Lowe T.M.
McLysaght A.
Mikkelsen T.
Moran J.V.
Mulder N.
Pollara V.J.
Ponting C.P.
Schuler G.
Schultz J.
Slater G.
Smit A.F.
Stupka E.
Szustakowski J.
Thierry-Mieg D.
Thierry-Mieg J.
Wagner L.
Wallis J.
Wheeler R.
Williams A.
Wolf Y.I.
Wolfe K.H.
Yang S.P.
Yeh R.F.
Collins F.
Guyer M.S.
Peterson J.
Felsenfeld A.
Wetterstrand K.A.
Patrinos A.
Morgan M.J.
de Jong P.
Catanese J.J.
Osoegawa K.
Shizuya H.
Choi S.
Chen Y.J.

Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team

Scherer S.E.
Muzny D.M.
Buhay C.J.
Chen R.
Cree A.
Ding Y.
Dugan-Rocha S.
Gill R.
Gunaratne P.
Harris R.A.
Hawes A.C.
Hernandez J.
Hodgson A.V.
Hume J.
Jackson A.
Khan Z.M.
Kovar-Smith C.
Lewis L.R.
Lozado R.J.
Metzker M.L.
Milosavljevic A.
Miner G.R.
Montgomery K.T.
Morgan M.B.
Nazareth L.V.
Scott G.
Sodergren E.
Song X.Z.
Steffen D.
Lovering R.C.
Wheeler D.A.
Worley K.C.
Yuan Y.
Zhang Z.
Adams C.Q.
Ansari-Lari M.A.
Ayele M.
Brown M.J.
Chen G.
Chen Z.
Clerc-Blankenburg K.P.
Davis C.
Delgado O.
Dinh H.H.
Draper H.
Gonzalez-Garay M.L.
Havlak P.
Jackson L.R.
Jacob L.S.
Kelly S.H.
Li L.
Li Z.
Liu J.
Liu W.
Lu J.
Maheshwari M.
Nguyen B.V.
Okwuonu G.O.
Pasternak S.
Perez L.M.
Plopper F.J.
Santibanez J.
Shen H.
Tabor P.E.
Verduzco D.
Waldron L.
Wang Q.
Williams G.A.
Zhang J.
Zhou J.
Allen C.C.
Amin A.G.
Anyalebechi V.
Bailey M.
Barbaria J.A.
Bimage K.E.
Bryant N.P.
Burch P.E.
Burkett C.E.
Burrell K.L.
Calderon E.
Cardenas V.
Carter K.
Casias K.
Cavazos I.
Cavazos S.R.
Ceasar H.
Chacko J.
Chan S.N.
Chavez D.
Christopoulos C.
Chu J.
Cockrell R.
Cox C.D.
Dang M.
Dathorne S.R.
David R.
Davis C.M.
Davy-Carroll L.
Deshazo D.R.
Donlin J.E.
D'Souza L.
Eaves K.A.
Egan A.
Emery-Cohen A.J.
Escotto M.
Flagg N.
Forbes L.D.
Gabisi A.M.
Garza M.
Hamilton C.
Henderson N.
Hernandez O.
Hines S.
Hogues M.E.
Huang M.
Idlebird D.G.
Johnson R.
Jolivet A.
Jones S.
Kagan R.
King L.M.
Leal B.
Lebow H.
Lee S.
LeVan J.M.
Lewis L.C.
London P.
Lorensuhewa L.M.
Loulseged H.
Lovett D.A.
Lucier A.
Lucier R.L.
Ma J.
Madu R.C.
Mapua P.
Martindale A.D.
Martinez E.
Massey E.
Mawhiney S.
Meador M.G.
Mendez S.
Mercado C.
Mercado I.C.
Merritt C.E.
Miner Z.L.
Minja E.
Mitchell T.
Mohabbat F.
Mohabbat K.
Montgomery B.
Moore N.
Morris S.
Munidasa M.
Ngo R.N.
Nguyen N.B.
Nickerson E.
Nwaokelemeh O.O.
Nwokenkwo S.
Obregon M.
Oguh M.
Oragunye N.
Oviedo R.J.
Parish B.J.
Parker D.N.
Parrish J.
Parks K.L.
Paul H.A.
Payton B.A.
Perez A.
Perrin W.
Pickens A.
Primus E.L.
Pu L.L.
Puazo M.
Quiles M.M.
Quiroz J.B.
Rabata D.
Reeves K.
Ruiz S.J.
Shao H.
Sisson I.
Sonaike T.
Sorelle R.P.
Sutton A.E.
Svatek A.F.
Svetz L.A.
Tamerisa K.S.
Taylor T.R.
Teague B.
Thomas N.
Thorn R.D.
Trejos Z.Y.
Trevino B.K.
Ukegbu O.N.
Urban J.B.
Vasquez L.I.
Vera V.A.
Villasana D.M.
Wang L.
Ward-Moore S.
Warren J.T.
Wei X.
White F.
Williamson A.L.
Wleczyk R.
Wooden H.S.
Wooden S.H.
Yen J.
Yoon L.
Yoon V.
Zorrilla S.E.
Nelson D.
Kucherlapati R.
Weinstock G.
Gibbs R.A.
null.

The finished DNA sequence of human chromosome 12.

Serine/threonine-protein kinase receptor R3


Eukaryota Metazoa Porifera Demospongiae Verongimorpha Chondrillida Halisarcidae Halisarca

Disordered

Disordered

Basic and acidic residues

Acidic residues


RPEL

RPEL

SAP

Disordered

Disordered

Disordered

Disordered

Disordered

Disordered

Basic and acidic residues

Basic and acidic residues

Polar residues

Basic and acidic residues

Low complexity

Polar residues

Basic residues

Basic and acidic residues

Basic and acidic residues

Pro residues

Mikhailov K.
Kravchuk O.
Lyupina Y.
Adameyko K.

P:positive regulation of transcription by RNA polymerase II

MYOCARDIN-RELATED TRANSCRIPTION FACTOR, ISOFORM H


Eukaryota Metazoa Echinodermata Eleutherozoa Echinozoa Holothuroidea Aspidochirotacea Aspidochirotida Stichopodidae Apostichopus

GB1/RHD3-type G

Guanylate-binding protein, C-terminal domain

P-loop containing nucleotide triphosphate hydrolases

Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain

P-loop containing nucleoside triphosphate hydrolases

Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family


Eukaryota Metazoa Ecdysozoa Arthropoda Chelicerata Arachnida Acari Acariformes Trombidiformes Prostigmata Eleutherengona Heterostigmata Tarsonemoidea Tarsonemidae Polyphagotarsonemus

Ligated ion channel binding I - glutamate

Helical

Helical

Helical

Genome insights into chemosensory and detoxification machineries of broad mite, Polyphagotarsonemus latus (Tarsonemidae: Acari).