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0296ee99dbe763ceaabec7ea58acb94c6ac7108f8403e7a567d55fccc0d3b8c9/peer_review/images_list.json

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02d5992943273e68aef5506831094e77cdd8a928fc769cdcb61e9bf76d3a4409/peer_review/images_list.json

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02e1743cee69bc1a7db10cf4c0bd148b57b0c52861ec56f8c2eba9309e3dd556/peer_review/images_list.json

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+[
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_0.jpg",
+    "caption": "Figure S1. Computational speeds for different aspects of software presented in main text. a) Shows the difference between an ODE model solved in python and AMICI for the number of species the model simulates. b) Shows the time course data (12 hours) of a randomized pulse experiment for both the model presented in the main text (19 states simulated in this version) and the E. coli core model (119 states simulated). The input flow rates are altered every 15 minutes. c) Shows the convergence time for each model trained with either 6 agents or 30 agents. d) Breaks down c and shows the median CPU given the number of simulated species per iteration i.e. solving a model 6 times means implies solved 114 ODE's for the first model and 714 solved ODEs for the E. coli core model. e) Shows the relative convergence scores of these optimizations (log normalized summed least squares error), the inset shows the absolute convergence values of the worst fit. f) Shows the average simulation time of each model given the number of ODEs that need to be solved, for the OED version of the models i.e. including sensitivity equations this takes a lot longer. g) Shows the time it takes to optimize a flow experiment for each model utilizing a single core (100 iterations of the algorithm).",
+    "bbox": [],
+    "page_idx": 0
+  }
+]

02fd2d41b676906576de4a0592feaab842ac98e948ed2aa9d305e34ca3091b7f/peer_review/images_list.json

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031533273448af5b0df2c63cca02bc0fbc6c14568c1016e047783942edddd989/peer_review/images_list.json

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+[
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_0.jpg",
+    "caption": "Figure R1. Total energy of the \\(\\mathrm{O_2 - Cr(h - fpyz)_2}\\) system as a function of some representative rotation angles \\((\\theta)\\) of two organic rings linked with the \\(\\mathrm{CrI}\\) reactive site.",
+    "bbox": [
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+        683,
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+      ]
+    ],
+    "page_idx": 6
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_1.jpg",
+    "caption": "Figure R2. Local electric field (LEF) around the \\(\\mathrm{CrI}\\) reactive site along the normal direction with (dotted line) and without (solid line) considering the screening effect, for both \\(\\mathrm{Cr(h - fpyz)_2}\\) (black line) and \\(\\mathrm{Cr(pyz)_2}\\) (red line) systems.",
+    "bbox": [
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+        109,
+        720,
+        393
+      ]
+    ],
+    "page_idx": 7
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_2.jpg",
+    "caption": "Figure R3. \\(\\mathrm{O_2}\\) adsorption on the surface \\(\\mathrm{CrI}\\) , \\(\\mathrm{Cr_{II}}\\) , and \\(\\mathrm{Cr_{III}}\\) reactive sites of the constructed 3D \\(\\mathrm{Cr(h - fpyz)_2}\\) structure simulated by a four-layered 2D \\(\\mathrm{Cr(h - fpyz)_2}\\) complex with the most stable AB stacking form.",
+    "bbox": [
+      [
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+        770,
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+      ]
+    ],
+    "page_idx": 13
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_3.jpg",
+    "caption": "Figure R4. Catalytic pathway for CO oxidation. Minimum energy pathway (MEP) for \\(\\mathrm{O_2}\\) activation and CO oxidation via the E-R mechanism on \\(\\mathrm{CrI}\\) reactive site in \\(\\mathrm{Cr(h - fpyz)_2}\\) . Here, \\(\\mathrm{*O_2(O)}\\) denotes the adsorption of \\(\\mathrm{O_2(O)}\\) on the catalytic substrate. \\(\\mathrm{CO - }\\) \\(\\mathrm{*O_2(O)}\\) and \\(\\mathrm{CO - *O_2(O)}\\) correspond to the relatively weak and strong interactions between the CO and the adsorbed \\(\\mathrm{O_2(O)}\\) species.",
+    "bbox": [
+      [
+        245,
+        88,
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+      ]
+    ],
+    "page_idx": 16
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_4.jpg",
+    "caption": "Figure R5. Local electric field (LEF) profiles of the \\(\\mathrm{Cr(h - fpvz)_2}\\) along the normal that cross the Cr atoms.",
+    "bbox": [
+      [
+        150,
+        609,
+        848,
+        748
+      ]
+    ],
+    "page_idx": 18
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_5.jpg",
+    "caption": "Figure R6. Catalytic pathway for CO oxidation on \\(\\mathrm{Cr_{II}}\\) reactive site in \\(\\mathrm{Cr(h- fpyz)_2}\\) .",
+    "bbox": [
+      [
+        272,
+        517,
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+      ]
+    ],
+    "page_idx": 19
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_6.jpg",
+    "caption": "Figure R7. Gibbs free energy change (ΔG), i.e., adsorption energy \\((E_{\\mathrm{ads}})\\) at \\(300\\mathrm{K}\\) with consideration of zero-point energy (ZPE) correction, with respect to the magnetic changes (ΔM) of (a) the Cr reactive sites, and (b) the other non-mental atoms, when \\(\\mathrm{O_2}\\) is adsorbed on the \\(\\mathrm{Cr_I}\\) , \\(\\mathrm{Cr_{II}}\\) , and \\(\\mathrm{Cr_{III}}\\) sites, respectively.",
+    "bbox": [
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+      ]
+    ],
+    "page_idx": 20
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_7.jpg",
+    "caption": "Figure R10. Local density of states (LDOS) for the initial (top panels) and final (bottom panels) optimized structures of the \\(\\mathrm{O_2}\\) molecule on (a) \\(\\mathrm{CrI}\\) and (b) \\(\\mathrm{CrIII}\\) reactive site of the \\(\\mathrm{Cr(h - fpyz)_2}\\) complex. In the initial configurations, the gas phase ground state \\(\\mathrm{O_2}\\) molecule is placed at least \\(10\\mathrm{\\AA}\\) above the reactive site.",
+    "bbox": [],
+    "page_idx": 22
+  }
+]

031e368a469fa7a49d7f45c82ca8e17995cf9776aa7caf1952c8b7077ee3f2da/peer_review/images_list.json

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+  {
+    "type": "image",
+    "img_path": "images/Figure_1.jpg",
+    "caption": "Fig. 1: Liquid crystal orientation during the SLA 3D printing process. (a) Preparation of LC-containing photosensitive resin. (b) Changing print layer thickness to control LC morphology. (c) LC orientation driving polymer orientation during printing.",
+    "bbox": [],
+    "page_idx": 0
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_4.jpg",
+    "caption": "Fig. 4: XRD results for PR-5CB samples printed in vertical and horizontal directions.",
+    "bbox": [
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+        546,
+        690,
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+      ]
+    ],
+    "page_idx": 13
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_6.jpg",
+    "caption": "Fig. 6: SEM images of the PR-5CB products printed in vertical and horizontal directions.",
+    "bbox": [
+      [
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+        510,
+        886,
+        732
+      ]
+    ],
+    "page_idx": 15
+  },
+  {
+    "type": "image",
+    "img_path": "images/Supplementary_Figure_2.jpg",
+    "caption": "Supplementary Fig. 2: POM images of the PR-5CB-3// resin surface at different temperatures",
+    "bbox": [
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+        92,
+        866,
+        245
+      ]
+    ],
+    "page_idx": 17
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_0.jpg",
+    "caption": "Before DCM extraction After DCM extraction",
+    "bbox": [
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+      ]
+    ],
+    "page_idx": 19
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_10.jpg",
+    "caption": "Fig. 10: X-ray diffraction of PR-5CB resins at different print resolutions and contents.",
+    "bbox": [
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+      ]
+    ],
+    "page_idx": 20
+  },
+  {
+    "type": "image",
+    "img_path": "images/Supplementary_Figure_3.jpg",
+    "caption": "Supplementary Fig. 3: (a) POM images of PR-5CB-7//(50 \\(\\mu \\mathrm{m}\\) ), with and without the extraction of 5CB LC. (b) POM images of the surface of the PR-5CB-7//(50 \\(\\mu \\mathrm{m}\\) ) resin at different temperatures.",
+    "bbox": [
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+    "page_idx": 22
+  },
+  {
+    "type": "image",
+    "img_path": "images/Supplementary_Figure_6.jpg",
+    "caption": "Supplementary Fig. 6: Stress-strain curves of different commercial printing formulations with \\(3\\%\\) content of 5CB.",
+    "bbox": [
+      [
+        172,
+        478,
+        868,
+        615
+      ]
+    ],
+    "page_idx": 24
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_14.jpg",
+    "caption": "Fig. 14: (a) Shrinkage of PR-5CB-3// resin at different resolutions. (b) Printing model of PR-5CB-3//(25 \\(\\mu \\mathrm{m}\\) ) treated at different temperatures. (c) Skeletonized spheres with a resolution of \\(2833 \\times 2918\\) pixels, and height of \\(150 \\mu \\mathrm{m}\\) magnified by \\(10 \\times\\) and \\(50 \\times\\) . (d) Printing model of macro-sized and micro-sized structures.",
+    "bbox": [],
+    "page_idx": 25
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_7.jpg",
+    "caption": "Fig. 7: Visual difference between the vertical and horizontal directions of the printed model.",
+    "bbox": [],
+    "page_idx": 27
+  },
+  {
+    "type": "image",
+    "img_path": "images/Supplementary_Figure_8.jpg",
+    "caption": "Supplementary Fig. 8: Polarizing optical microscopy (POM) of different prepolymer printing formulations with a 3% content of 5CB. Images were taken at angles of 0° and 45°.",
+    "bbox": [
+      [
+        168,
+        140,
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+      ]
+    ],
+    "page_idx": 28
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_6.jpg",
+    "caption": "Fig. 6: SEM images of the PR-5CB products printed in vertical and horizontal directions.",
+    "bbox": [
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+      ]
+    ],
+    "page_idx": 30
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_1.jpg",
+    "caption": "Fig. 1: Liquid crystal orientation during the SLA 3D printing process. (a) Preparation of LC-containing photosensitive resin. (b) Changing print layer thickness to control LC morphology. (c) LC orientation driving polymer orientation during printing.",
+    "bbox": [
+      [
+        188,
+        388,
+        880,
+        660
+      ]
+    ],
+    "page_idx": 32
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_7.jpg",
+    "caption": "Fig. 7: Visual difference between the vertical and horizontal directions of the printed model.",
+    "bbox": [
+      [
+        192,
+        286,
+        580,
+        640
+      ]
+    ],
+    "page_idx": 34
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_14.jpg",
+    "caption": "Fig. 14: (a) Shrinkage of PR-5CB-3// resin at different resolutions. (b) Printing model of PR-5CB-3//(25 \\(\\mu \\mathrm{m}\\) ) treated at different temperatures. (c) Skeletonized spheres with a resolution of \\(2833 \\times 2918\\) pixels, and height of \\(150 \\mu \\mathrm{m}\\) magnified by \\(10 \\times\\) and \\(50 \\times\\) . (d) Printing model of macro-sized and micro-sized structures.",
+    "bbox": [
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+    "page_idx": 36
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0986baca78f5b40819f004daf2eb76d7f4f4f10f91bb0b965eadad53992e8b0b/peer_review/images_list.json

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+[
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_0.jpg",
+    "caption": "Figure S3. Activity assessment of ABA3 proteins. (a) The PPi release rate of full-length and N-terminus truncated BcABA3, RuABA3 and SkABA3 when using FPP as a substrate, and the relative activities of each sample were presented as percentages of BcABA3-FL. The individual and average values of each sample in the triplicate assay were presented in dots and bars, respectively. (b) The reaction products of full-length and N-terminus truncated BcABA3 and RuABA3 were analyzed by GC-MS. The GC-MS chromatograms (left panel, \\(m / z\\) 133 and 148) MS spectra (right panel) of reaction product of each enzyme are displayed. Note that the intact \\((m / z, 204.20)\\) and two main fragment ions \\((m / z, 148.1\\) and 133.1) resulted from a retro-Diels-Alder fragmentation of \\((2Z,4E)\\) - \\(\\alpha\\) -ionylideneethane as previously described can be identified in both enzyme reactions<sup>1</sup>.",
+    "bbox": [
+      [
+        258,
+        108,
+        732,
+        585
+      ]
+    ],
+    "page_idx": 5
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_1.jpg",
+    "caption": "Figure S5. Size exclusion chromatographic analyses of ABA3 proteins. Red and black lines represent the chromatogram trace of standard protein markers and recombinant protein of each ABA3, respectively. The theoretical molecular weight of the single polypeptide of individual protein (theor.) and the molecular mass in solution calculated from the standard curve (cal.) are shown in each panel.",
+    "bbox": [
+      [
+        238,
+        90,
+        761,
+        595
+      ]
+    ],
+    "page_idx": 7
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_1b.jpg",
+    "caption": "Figure S4. Overall structure of RuABA3 and SkABA3. The overall structures of (a) RuABA3 and (b) chain A in the apo-SkABA3 structure are displayed in cartoon model. The helix labeling, metal ion and the breaking points on helix \\(\\alpha 11\\) , \\(\\alpha 11'\\) and \\(\\alpha 12\\) are indicated as in Fig. 1b. Right panels are structural superimposition of BcABA3 (green).",
+    "bbox": [
+      [
+        231,
+        181,
+        760,
+        542
+      ]
+    ],
+    "page_idx": 8
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_2.jpg",
+    "caption": "Figure S9. Three polypeptide chains in the apo-\\(S k A B A 3\\) crystal. Two views of the three polypeptide chains in an asymmetric unit of the apo-\\(S k A B A 3\\) crystal structure (PDB ID, 8ZAF) are presented in cyan, gray and orange cartoon models. The two that form a homodimer (cyan and gray) in the same configuration as \\(B c A B A 3\\) and \\(R u A B A 3\\) are noted.",
+    "bbox": [
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+        98,
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+        330
+      ]
+    ],
+    "page_idx": 9
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_3.jpg",
+    "caption": "Figure S10. GS-MS analyses of the reaction product of SkABA3. (a) The total ion chromatograms of FPP converted by SkABA3 (blue trace) and BcABA3 (red trace). (b) The mass spectra of \\((2Z,4E)\\) - \\(\\alpha\\) - ionylideneethane produced by BcABA3 (7.65 min) and the main peak in the reaction mixture catalyzed by SkABA3 (8.36 min).",
+    "bbox": [
+      [
+        188,
+        260,
+        816,
+        558
+      ]
+    ],
+    "page_idx": 10
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_4.jpg",
+    "caption": "Figure 4. The roles of the active site residues in BcABA3-catalyzed reaction. (a) The PPi release activity of wild type and variant BcABA3. The relative activities of each sample were presented as percentages of BcABA3-FL. The individual and average values of each sample in the triplicate assay were presented in dots and bars, respectively. (b) The reaction mixtures of wild type and variant BcABA3 were analyzed by GC-MS. The GC-MS chromatograms (left panel, \\(m / z\\) 133 and 148) of reaction mixture of each enzyme are displayed. The mass spectrum of \\((E)\\) - \\(\\beta\\) -farnesene is shown in Fig. S16. (c) Two views depicting the substrate interaction network observed in RuABA3/FSPP related at Y-axis by \\(180^{\\circ}\\) are displayed. Amino acid residues, FSPP and metal ions are shown in lines, sticks and spheres. The hydrophilic interactions measured within \\(3.5\\mathrm{\\AA}\\) are shown in purple dashed lines. The Y96-mediated packing force is noted",
+    "bbox": [
+      [
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+        87,
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+      ]
+    ],
+    "page_idx": 12
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_4.jpg",
+    "caption": "Figure S10. GS-MS analyses of the reaction product of SkABA3. (a) The total ion chromatograms of FPP converted by SkABA3 (blue trace) and BcABA3 (red trace). (b) The mass spectra of \\((2Z,4E)\\) - \\(\\alpha\\) -ionylideneethane produced by BcABA3 (7.65 min) and the main peak in the reaction mixture catalyzed by SkABA3 (8.36 min).",
+    "bbox": [
+      [
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+        168,
+        792,
+        444
+      ]
+    ],
+    "page_idx": 15
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_5.jpg",
+    "caption": "Figure S16. The mass spectrum of \\((E)\\) - \\(\\beta\\) -farnesene.",
+    "bbox": [],
+    "page_idx": 17
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_6.jpg",
+    "caption": "Figure S8. The role of the \\(\\mathrm{Zn^{2 + }}\\) -binding residues in \\(BcABA3\\) . The (a) PPI release rate, (b) atomic spectrometric analyses and (c) CD analyses of wild type and variants with the \\(\\mathrm{Zn^{2 + }}\\) -coordinating residues substituted with Ala. (d) The cartoon model of the apo-form \\(BcABA3\\) with the \\(\\mathrm{Zn^{2 + }}\\) -coordinating residues and \\(\\mathrm{Zn^{2 + }}\\) ion respectively",
+    "bbox": [
+      [
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+        418,
+        803,
+        825
+      ]
+    ],
+    "page_idx": 18
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_2.jpg",
+    "caption": "Figure S11. The omit maps of ligands bound in the RuABA3 and SkABA3 complex structures. The enzyme-ligand interaction networks in the complex structures RuABA3/FSPP (PDB ID, 8ZAE) and SkABA3/PPi (PDB ID, 8ZAG) are depicted as described in Fig. 2. The \\(F_{\\mathrm{o}} - F_{\\mathrm{c}}\\) polder omit maps of FSPP, PPi, \\(\\mathrm{Mg^{2 + }}\\) ions and coordinating waters contoured at \\(3.0\\sigma\\) are shown in mesh. Two views relative at the Y-axis by \\(180^{\\circ}\\) are presented. Dashed lines indicate distance \\(< 3.5\\mathrm{\\AA}\\) .",
+    "bbox": [
+      [
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+        163,
+        781,
+        550
+      ]
+    ],
+    "page_idx": 19
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_7.jpg",
+    "caption": "Figure S15. CD spectra of wild type and variants BcABA3 proteins.",
+    "bbox": [],
+    "page_idx": 24
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_8.jpg",
+    "caption": "Figure S8. The role of the \\(\\mathbf{Z}\\mathbf{n}^{2 + }\\) ion-binding residues in BcABA3. The (a) PPI release rate, (b) atomic spectrometric analyses and (c) CD analyses of wild type and variants with the \\(\\mathrm{Zn}^{2 + }\\) -coordinating residues substituted with Ala. (d) The cartoon model of the apo-form BcABA3 with the \\(\\mathrm{Zn}^{2 + }\\) ion-coordinating residues and \\(\\mathrm{Zn}^{2 + }\\) ion respectively labeled by sticks and a sphere. The region and residues colored in blue are absent in BcABA3-S, a natural variant of BcABA3 that does not produce \\((2Z,4E)\\) -a-ionylideneethane. The central cavity that accounts for the catalytic center is indicated by the dashed circle. The N- and C-terminus of the polypeptide are indicated.",
+    "bbox": [
+      [
+        201,
+        252,
+        803,
+        656
+      ]
+    ],
+    "page_idx": 25
+  }
+]

0988681af5fb0b959fbb957733368d6d553dc141f4b27b0d7b95c7144e5d5402/peer_review/images_list.json

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098ddd9e6616a135d268798217d55aa269660b9e1b01881d2c24cabbd4ecf5b0/peer_review/images_list.json

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+[
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_0.jpg",
+    "caption": "Figure R1. Equilibrium adsorption capacity (qe) of AOPIM-1 for MO and MB dye molecules at different pH conditions.",
+    "bbox": [],
+    "page_idx": 0
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_1.jpg",
+    "caption": "Figure R2. Energy optimized molecular model and adsorption energies of AOPIM-1 to MB, MO and \\(\\mathrm{H}_2\\mathrm{O}\\) molecule.",
+    "bbox": [
+      [
+        308,
+        585,
+        691,
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+    ],
+    "page_idx": 6
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_2.jpg",
+    "caption": "Figure R3. Pore size of membranes prepared in different coagulation baths.",
+    "bbox": [
+      [
+        332,
+        333,
+        677,
+        527
+      ]
+    ],
+    "page_idx": 7
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_3.jpg",
+    "caption": "Figure R4. MWCO curve and pore size distribution of M6.",
+    "bbox": [
+      [
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+        578,
+        691,
+        778
+      ]
+    ],
+    "page_idx": 8
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_4.jpg",
+    "caption": "Figure R5. Effects of different concentrations of dyes on (a) flux, (b) rejection, and (c) processing capacity.",
+    "bbox": [
+      [
+        210,
+        510,
+        816,
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+      ]
+    ],
+    "page_idx": 8
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_5.jpg",
+    "caption": "Figure R6. Equilibrium adsorption capacity \\((q_{e})\\) of AOPIM-1 for MO and MB dye molecules at different pH conditions;",
+    "bbox": [
+      [
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+        380,
+        686,
+        595
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+    "page_idx": 9
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+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_6.jpg",
+    "caption": "Figure R8. Mechanical properties of AOPIM-1 adsorption membranes under different treatment conditions.",
+    "bbox": [],
+    "page_idx": 11
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_7.jpg",
+    "caption": "Figure R8. Mechanical properties of AOPIM-1 adsorption membranes under different treatment conditions.",
+    "bbox": [
+      [
+        189,
+        85,
+        825,
+        263
+      ]
+    ],
+    "page_idx": 11
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_8.jpg",
+    "caption": "Figure R9. (b) Pore size distributions of pristine, adsorbed and desorbed AOPIM-1 membrane, respectively; (c) Nitrogen absorption-desorption isotherms of pristine, adsorbed and desorbed AOPIM-1, respectively.",
+    "bbox": [
+      [
+        180,
+        234,
+        780,
+        399
+      ]
+    ],
+    "page_idx": 13
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_9.jpg",
+    "caption": "Figure R10. Breakthrough curves (Ref. 29) showing dynamic adsorption of rose bengal using the (a) bare \\(\\alpha\\) -alumina support and membrane samples:(b) ZIF-8, (c) ZIF-L (no CTAB), (d) ZIF-L (CTAB, \\(1\\times\\) ), (e) ZIF-L (CTAB, \\(2\\times\\) ), and (f) ZIF-L (CTAB, \\(8\\times\\) ).",
+    "bbox": [
+      [
+        273,
+        163,
+        722,
+        485
+      ]
+    ],
+    "page_idx": 15
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_10.jpg",
+    "caption": "Figure R11. Processing capacity of AOPIM-1 membranes (coagulation bath composition: H2O:EtOH = 50:50).",
+    "bbox": [
+      [
+        236,
+        344,
+        808,
+        504
+      ]
+    ],
+    "page_idx": 16
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_11.jpg",
+    "caption": "Figure R12. Comparison of AOPIM-1 membranes with reported membranes with respect to their permeation flux and dye rejection/removal efficiency.",
+    "bbox": [
+      [
+        266,
+        92,
+        680,
+        333
+      ]
+    ],
+    "page_idx": 18
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_12.jpg",
+    "caption": "Figure R13. Molecular formula and model size (Å) of different dyes referred in this work.",
+    "bbox": [
+      [
+        180,
+        90,
+        816,
+        666
+      ]
+    ],
+    "page_idx": 19
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_13.jpg",
+    "caption": "Figure R1. Equilibrium adsorption capacity (qe) of AOPIM-1 for MO and MB dye molecules at different pH conditions.",
+    "bbox": [
+      [
+        325,
+        85,
+        670,
+        300
+      ]
+    ],
+    "page_idx": 21
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_14.jpg",
+    "caption": "Figure R2. Separation performance of polyethersulfone ultrafiltration membrane and AOPIM-1 membrane against the MB dye feed solution.",
+    "bbox": [
+      [
+        250,
+        370,
+        745,
+        565
+      ]
+    ],
+    "page_idx": 22
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_15.jpg",
+    "caption": "Figure R3. The surface and cross-sectional (a,c,e) SEM images and sulfur element distribution (b,d,f) in EDX mapping images of AOPIM-1 membrane after the dynamic adsorption experiment.",
+    "bbox": [
+      [
+        231,
+        95,
+        765,
+        540
+      ]
+    ],
+    "page_idx": 26
+  }
+]

09b52bdc64646ee102c5eefd8d40ebe8aebaa4d3bee21b77538f49ab826485e2/peer_review/images_list.json

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+  {
+    "type": "image",
+    "img_path": "images/Supplementary_Figure_6.jpg",
+    "caption": "Supplementary Figure 6. Comparison between Blocky fossil phytoliths extracted from the digestive tract content of Jeholornis (IVPP V14978)(a)and Blocky Phytoliths with ridgeline ornament extracted from modern Magnoliaceae(b-h). a, fossil blocky phytoliths with wavy ridgelines from the stomach content of Jeholornis (IVPP V14978), possibly related to blocky phytoliths in modern Magnoliales leaves.b, Lirianthe henryi (Dunn) N.H. Xia & C.Y. Wu; c,Magnolia coco (Lour.) DC. d, Manglietia decidua Q.Y. Zheng; e, Manglietia fordiana Oliv.; f, Yulania",
+    "bbox": [],
+    "page_idx": 0
+  },
+  {
+    "type": "image",
+    "img_path": "images/Supplementary_Figure_7.jpg",
+    "caption": "Supplementary Figure 7. Comparison between hair base phytoliths extracted from the digestive tract content of Jeholornis (IVPP V14978) (d,e) and hair base phytoliths extracted from extant Ficus tikuou leaves (f). Blue is center papillae of hair base. Red is the surrounding cells whose cell walls formed the surounding radiate lines. These two key characteristics from fossil hair base are consistent with modern hair base.",
+    "bbox": [
+      [
+        212,
+        150,
+        784,
+        710
+      ]
+    ],
+    "page_idx": 7
+  }
+]

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+  {
+    "type": "image",
+    "img_path": "images/Supplementary_Figure_6.jpg",
+    "caption": "Supplementary Figure 6. Spatiotemporal patterns of the area-averaged and EOF-based December-May NAO. (top panels) Spatial patterns of the area-averaged December-May NAO derived from (left) ERA5, (middle) NCEP1 and (right) JRA55. (middle panels) Spatial patterns of the EOF-based December-May NAO derived from (left) ERA5, (middle) NCEP1 and (right) JRA55. (bottom panel) 5-year running-mean time series of the area-averaged (solid lines) and EOF-based (dashed lines) December-May NAO derived from ERA5 (blue), NCEP1 (red), and",
+    "bbox": [
+      [
+        111,
+        190,
+        886,
+        789
+      ]
+    ],
+    "page_idx": 7
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_7.jpg",
+    "caption": "Fig. 7 from Smeed et al. (2014). Annual average estimates of the AMOC from the 26N array (red, Sv right axis, error bar \\(= 1.5\\) Sv), estimates of the AMOC from 6 hydrographic sections (black, Sv right axis, error bar \\(= 5\\) Sv), the time series of annual average values of the AMO (blue, \\(^\\circ \\mathrm{C}\\) left axis) and accumulated NAO index (green, arbitrary units).",
+    "bbox": [
+      [
+        115,
+        88,
+        525,
+        316
+      ]
+    ],
+    "page_idx": 14
+  },
+  {
+    "type": "image",
+    "img_path": "images/Supplementary_Figure_1.jpg",
+    "caption": "Supplementary Figure 1. Decade-averaged time series of the AMOC anomalies at \\(26.5^{\\circ}\\mathrm{N}\\) from 10 OMIP2 models. Decade-averaged time series of the AMOC anomalies at \\(26.5^{\\mathrm{o}}\\mathrm{N}\\) from the decade centered in 1960 (i.e., 1958-64) to the decade centered in 2010 (i.e., 2005-14), derived from ten OMIP2 models used in this study.",
+    "bbox": [
+      [
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+        84,
+        884,
+        420
+      ]
+    ],
+    "page_idx": 18
+  },
+  {
+    "type": "image",
+    "img_path": "images/Supplementary_Figure_2.jpg",
+    "caption": "Supplementary Figure 2. Decade-averaged time series of the AMOC anomalies at \\(26.5^{\\circ}\\mathrm{N}\\) in high and low resolution OMIP2 models. (a) Decade-averaged time series of the AMOC anomalies at \\(26.5^{\\circ}\\mathrm{N}\\) from the decade centered in 1960 (i.e., 1958-64) to the decade centered in 2010 (2005-14), derived from four sets of high and low resolution OMIP2 models discussed in Chassignet et al. (2020). (b) Same as (a) except that the rate of interdecadal AMOC change is shown. The error bars in (a) indicate standard deviation from the ensemble-mean. Note that OMIP2 model runs are typically carried out for 366 years by repeating six cycles of the 61-year (1958-2018). However, for the high and low resolution OMIP2 simulations used in ref 1, no spin-up run was carried out. Hence, the AMOC time series during the first 17 years (i.e., 1958-1974) are stippled because they are contaminated by spin-up issues1, and thus should be disregarded.",
+    "bbox": [
+      [
+        228,
+        85,
+        768,
+        560
+      ]
+    ],
+    "page_idx": 19
+  },
+  {
+    "type": "image",
+    "img_path": "images/Supplementary_Figure_4.jpg",
+    "caption": "Supplementary Figure 4. Interdecadal time series of the externally forced AMOC and its rate of change at \\(26.5^{\\circ}\\mathrm{N}\\) in low and medium resolution HadGEM3-GC31. (a) Interdecadal time series of the externally forced AMOC and (b) its rate of change at \\(26.5^{\\circ}\\mathrm{N}\\) derived from HadGEM3-GC31-MM (red), HadGEM3-GC31-LL (sky blue) and the difference between the two (purple). The error bars in (a) indicate standard deviation from the ensemble-mean.",
+    "bbox": [],
+    "page_idx": 20
+  },
+  {
+    "type": "image",
+    "img_path": "images/Supplementary_Figure_5.jpg",
+    "caption": "Supplementary Figure 5. Interdecadal time series of the AMOC and its rate of change at \\(26.5^{\\circ}\\mathrm{N}\\) based on low and medium resolution HadGEM3-GC31. (a,b) Interdecadal time series of the AMOC and (b,d) its rate of change at \\(26.5^{\\circ}\\mathrm{N}\\) based on (a,b) HadGEM3-GC31-LL and (c,d) HadGEM3-GC31-MM. The error bars in (a,c) indicate standard deviation from the ensemble-mean.",
+    "bbox": [
+      [
+        113,
+        85,
+        880,
+        425
+      ]
+    ],
+    "page_idx": 22
+  }
+]

0ae095e4601335f806966eda85cd44ddaab029846fb71b47faa2768ba5776ad3/peer_review/images_list.json

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+  {
+    "type": "image",
+    "img_path": "images/Supplementary_Figure_7.jpg",
+    "caption": "“Supplementary Figure 7 | Comparison of the SEM images and EDS spectrum of the",
+    "bbox": [],
+    "page_idx": 5
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_0.jpg",
+    "caption": "Figure R1. Comparison of the ML emission during the compression and decompression.",
+    "bbox": [],
+    "page_idx": 7
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_2c.jpg",
+    "caption": "Figure R2. The enlarged figure of Figure. 2c",
+    "bbox": [
+      [
+        264,
+        197,
+        744,
+        589
+      ]
+    ],
+    "page_idx": 10
+  },
+  {
+    "type": "image",
+    "img_path": "images/Supplementary_Figure_1.jpg",
+    "caption": "Supplementary Figure 1 | Characterization of the structure, morphology and elements of SrZnOS: \\(\\mathrm{Mn}^{2 + }\\) . a, Powder XRD patterns of SrZnOS: \\(x\\mathrm{Mn}\\) ( \\(x = 0\\) , 0.00, 0.005,",
+    "bbox": [],
+    "page_idx": 11
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_1.jpg",
+    "caption": "Figure R3. Rate-dependent ML kinetics of \\(\\mathrm{ZnS}\\) : \\(\\mathrm{Mn}^{2 + }\\) under rapid compression. The oscillatory ML emission appears at the critical rates.",
+    "bbox": [],
+    "page_idx": 13
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_4.jpg",
+    "caption": "Fig. 4 | Pressure-induced evolution of crystal structures and photoluminescence. a In-situ high-pressure synchrotron XRD patterns of Mn-doped SrZnOS. b d-space and (c) unit cell volume and lattice parameters as a function of the pressure. d High-pressure PL spectra of SrZnOS: Mn \\(^{2 + }\\) excited by the laser of 375 nm. e PL intensity as a function of pressure. The inset figure in Fig. 4e is the lifetime of SrZnOS: Mn \\(^{2 + }\\) as a function of pressure.",
+    "bbox": [],
+    "page_idx": 15
+  },
+  {
+    "type": "image",
+    "img_path": "images/Supplementary_Figure_9.jpg",
+    "caption": "Supplementary Figure 9 | ML response under compression and decompression. Additional ML emission due to the fracture of the crystal grains at temperatures of (a) 298 K and (b) 373 K. c, the ML intensity decreases during cyclic compression and decompression processes in the pressure range of 0-10 GPa at 298 K. d and e, The ML emission response during the cyclic compression-decompression processes with the number of cycles over 100 in the pressure range of 0-5 GPa. It can be seen that the ML intensity decreases during the initial compression-decompression processes, but becomes stable as the cyclic number increases.",
+    "bbox": [],
+    "page_idx": 15
+  }
+]

0afc5fd8bc20909da9586f52f7ba74888c5d3809eb3782695b4832adf305cb35/peer_review/images_list.json

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+[
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_0.jpg",
+    "caption": "Fig. R1. Phage particles in lysates of DEV (red symbols) or DEV Δgp56 (green symbols) were pelleted by PEG - NaCl precipitation. Both the supernatants and the pellets were analyzed by Real-Time PCR with a pair of phage-specific oligonucleotides before and after treating the samples with DNase I, which degrades only un-packed DNA or DNA released from particles, but not DNA inside the phage head. Left panel: relative amount of phage DNA in pellets (P) and supernatants (SN) before the treatment with DNase I. Right panel: Relative amount of phage DNA content in samples not treated with DNase I vs. treated samples. The proportion of DNA found in both the pellet and supernatant is comparable for both phages, indicating that the absence of gp56 does not affect DNA packaging. However, DNase I treatment significantly reduced the DNA content in both supernatants, while its impact on the DEV pellet was much lower (an average decrease of 2.6±0.29 fold between treated and untreated samples). Conversely, DNase I degraded the DEV Δgp56 DNA present in the pellet, indicating that the phage genome had (partially) leaked from the phage particles.",
+    "bbox": [],
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0b4db37797a4e1f607f20c86145a49572dc101848aea315cbc00560c1fdf0fb8/peer_review/images_list.json

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+[
+  {
+    "type": "image",
+    "img_path": "images/Figure_2.jpg",
+    "caption": "Fig. 2. Generation of streaming potential within the microfluidic device. (a) Illustration of the streaming potential measurement system using a voltmeter between the two electrodes and the Smoluchowski's equation. Pressure drop \\((\\Delta P)\\) and streaming potential \\((E_{\\mathrm{str}})\\) were measured using the cotton wool filling or the phenolic resin monolith no. 1 filling during pumping of the MeCN/H2O (3:1 v/v) solution containing 0.5 mM \\(\\mathrm{Bu_4NPF_6}\\) and \\(5\\mathrm{mMTPrA}\\) . The relationship between (b) \\(\\Delta P\\) and flow rate and (c) \\(E_{\\mathrm{str}}\\) and \\(\\Delta P\\) . The black squares indicate the values measured with the phenolic resin monolith no. 1 as a filler, whereas the blue triangles represent the values measured with the cotton wool as a filler. Black and blue dotted lines represent the linear fitting. \\(S_{\\mathrm{f}}\\) indicates the standard deviation about the regression.",
+    "bbox": [],
+    "page_idx": 16
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_5.jpg",
+    "caption": "Fig. 5. ECL detection of amines in aqueous solutions using the streaming potential device. (a) Dependence of the ECL intensity on the concentration of TPrA using an electrolyte-free MeCN/H2O (3:1 v/v) solution at the flow rate of \\(0.30\\mathrm{mL}\\mathrm{min}^{-1}\\) . (b) ECL emission profiles obtained during the flow of a MeCN/H2O (3:1 v/v) solution containing different amines (1 mM each) at the flow rate of \\(0.30\\mathrm{mL}\\mathrm{min}^{-1}\\) . (c) ECL emission profiles obtained using a fully aqueous system as the electrolyte: distilled water or tap water solutions containing 1 mM TPrA were injected into the flow cell at the flow rate of 0.30 mL min-1. All measurements were performed using the resin monolith no. 1 as the filling material.",
+    "bbox": [
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+  {
+    "type": "image",
+    "img_path": "images/Supplementary_Figure_3.jpg",
+    "caption": "Supplementary Figure 3. Representation of the three classification systems in the NHS England and the impact of using them. High-level codes are the broader ethnicity categories whilst those SNOMED represent the most granular groups available. Use of NHS or SNOMED codes show differences across different ethnic groups that are masked when using the high-level codes. For instance, Arab men had lower incidence COVID-19 death compared to Other Ethnic Group, whilst incidence of COVID-19 death in the Central/South/Latin America population was more than double. The red dotted line indicates the age-standardised incidence rates of the Other Ethnic group.",
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+  {
+    "type": "image",
+    "img_path": "images/Figure_3.jpg",
+    "caption": "Figure 3 Electrochemical response during lithiation or sodiation. a-b, \\(1^{\\mathrm{st}}\\) electrochemical cycle under",
+    "bbox": [],
+    "page_idx": 0
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_1.jpg",
+    "caption": "Figure 1 Schematic illustrations depicting the particle size dependent phase evolutions of olivine FePO4 particles during lithiation or sodiation. Different color codes denote different phases during lithiation or sodiation. Here, we grouped the particles based on their different phase evolution pathways upon lithiation and sodiation. Some previous works also witnessed some phase transformations, including solid solution (SS) transition during lithiation<sup>20-22,28</sup>, phase separation transition during lithiation<sup>25,26</sup>, SS transition out of structural equilibrium during lithiation<sup>27-31</sup>, and two-stage sodiation transition (phase separation + SS transition)<sup>32</sup>. In this work, we observed SS (out of structural equilibrium) transition upon sodiation. The dashed box in the diagram indicates the equilibrium SS transition throughout the range upon sodiation has not been observed experimentally.",
+    "bbox": [
+      [
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+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_0.jpg",
+    "caption": "XPS spectrum of Bi 4f for Bi \\(_x\\) I \\(_y\\) and BiI \\(_3\\)",
+    "bbox": [],
+    "page_idx": 0
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_1.jpg",
+    "caption": "Bismuth based 2D perovskite heterostructure and its diffuse reflectance spectrum exhibits a dual bandgap.",
+    "bbox": [
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+        150,
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+        850,
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+[
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_0.jpg",
+    "caption": "Author response image 2:",
+    "bbox": [],
+    "page_idx": 0
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_1.jpg",
+    "caption": "Author response image 3:",
+    "bbox": [],
+    "page_idx": 7
+  }
+]

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+[
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_0.jpg",
+    "caption": "Figure: Respiration measured over time for an agricultural and geothermal soil. Colour indicates incubation temperature and lines indicate best fit.",
+    "bbox": [],
+    "page_idx": 0
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_1.jpg",
+    "caption": "Figure: Example temperature response curves of soil respiration without glucose amendment. The first example (FODAF) does not exhibit a clear \\(T_{opt}\\) , suggesting that abiotic processes may dominate the reaction rates in this soil. In contrast, the second example (MIJOZ) shows a clear \\(T_{opt}\\) , indicating a strong biotic contribution to respiration rates. This complicates the comparison of thermal adaptation rates between the microbial communities in these two soils using this approach, as the confounding factor of biotic versus abiotic influences is not accounted for.",
+    "bbox": [
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+[
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_0.jpg",
+    "caption": "Figure R1: Reversible intercalation experiment of \\(\\mathrm{TiO_2}\\) nanofiber film.",
+    "bbox": [],
+    "page_idx": 0
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_1.jpg",
+    "caption": "Figure R2: Intercalation experiment of lithium in the \\(\\mathrm{Nb_2O_5}\\) nanofiber film.",
+    "bbox": [
+      [
+        348,
+        111,
+        647,
+        363
+      ]
+    ],
+    "page_idx": 5
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_2.jpg",
+    "caption": "Figure R3: The intercalated ceramic nanofiber films synthesized with the same method.",
+    "bbox": [
+      [
+        178,
+        508,
+        820,
+        771
+      ]
+    ],
+    "page_idx": 6
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_3.jpg",
+    "caption": "Figure R4: The as-prepared simple electrochromic device. After injecting a drop of DMAc/LiClO4 liquid, the sealed TiO2 nanofiber film quickly turns black.",
+    "bbox": [
+      [
+        184,
+        85,
+        808,
+        208
+      ]
+    ],
+    "page_idx": 9
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_4.jpg",
+    "caption": "Figure R5: The comparison of catalysis performance between the white \\(\\mathrm{Nb_2O_5}\\) and the black \\(\\mathrm{Nb_2O_5 - x}\\) for photocatalytic reduction of \\(\\mathrm{CO_2}\\) into CO and \\(\\mathrm{CH_4}\\) . Obviously, the black catalyst films exhibited better selectivity of \\(\\mathrm{CH_4}\\) conversion.",
+    "bbox": [
+      [
+        222,
+        265,
+        775,
+        440
+      ]
+    ],
+    "page_idx": 10
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_5.jpg",
+    "caption": "Figure R6: (a) The scalable machine for fabricating large-scale ceramic nanofiber films. (b) A large piece of the soft ceramic nanofiber film.",
+    "bbox": [
+      [
+        149,
+        477,
+        827,
+        606
+      ]
+    ],
+    "page_idx": 10
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_6.jpg",
+    "caption": "Figure R7: The estimated nominal lithium concentration \\(x\\) in \\(Li_xTiO_2\\) .",
+    "bbox": [
+      [
+        315,
+        625,
+        675,
+        830
+      ]
+    ],
+    "page_idx": 11
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_7.jpg",
+    "caption": "Figure R8: Dynamic behavior of DMAC on \\(\\mathrm{TiO_2}\\) nanofiber film.",
+    "bbox": [
+      [
+        201,
+        225,
+        795,
+        384
+      ]
+    ],
+    "page_idx": 12
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_8.jpg",
+    "caption": "Figure R9: Schematic diagram of the interaction between DMAC and lithium.",
+    "bbox": [
+      [
+        270,
+        415,
+        725,
+        592
+      ]
+    ],
+    "page_idx": 14
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_9.jpg",
+    "caption": "Figure R10: XRD patterns of the white \\(\\mathrm{TiO_2}\\) , black \\(\\mathrm{Li_xTiO_2 - \\delta}\\) and \\(\\mathrm{D - Li_xTiO_2 - \\delta}\\) nanofiber films.",
+    "bbox": [
+      [
+        192,
+        644,
+        792,
+        821
+      ]
+    ],
+    "page_idx": 14
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_10.jpg",
+    "caption": "Figure R11: XRD patterns of the white \\(\\mathrm{TiO_2}\\) , and black \\(\\mathrm{Li_xTiO_{2 - \\delta}}\\) nanofiber films with a long-time intercalation of lithium.",
+    "bbox": [
+      [
+        323,
+        90,
+        671,
+        303
+      ]
+    ],
+    "page_idx": 15
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_11.jpg",
+    "caption": "Figure R12: Long-term cycling performance of the white \\(\\mathrm{TiO_2}\\) and black \\(\\mathrm{Li_xTiO_2 - \\delta}\\) nanofiber anode films.",
+    "bbox": [
+      [
+        235,
+        92,
+        760,
+        303
+      ]
+    ],
+    "page_idx": 16
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_12.jpg",
+    "caption": "Figure R13. Simulation and calculation characterizations. (a) Optimized geometric structures and charge difference density mappings for the Li-adsorbed TiO2. (b) PDOS plots of the initial and the intercalated TiO2. (c-d) Li+-ions diffusion pathway for Li4TiO2 and D-Li4TiO2.6. (e) Band structure of Li4TiO2 and D-Li4TiO2.6. (f) Li+-ions diffusion energy barriers in Li4TiO2 and D-Li4TiO2.6. (g) EPR spectra and (h) Raman spectra of TiO2 before and after the intercalation.",
+    "bbox": [
+      [
+        155,
+        80,
+        825,
+        620
+      ]
+    ],
+    "page_idx": 17
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_13.jpg",
+    "caption": "Figure R7: The estimated nominal lithium concentration \\(x\\) in \\(Li_xTiO_2\\) .",
+    "bbox": [
+      [
+        303,
+        667,
+        684,
+        881
+      ]
+    ],
+    "page_idx": 19
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_14.jpg",
+    "caption": "Figure R14: Changes in conductivity of \\(\\mathrm{Li}_x\\mathrm{TiO}_{2 - \\delta}\\) nanofiber films over time.",
+    "bbox": [
+      [
+        320,
+        396,
+        675,
+        601
+      ]
+    ],
+    "page_idx": 22
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_15.jpg",
+    "caption": "Figure R15: Optical photos of \\(Li_xTiO_{2 - \\delta}\\) nanofiber films after lithium intercalation for long enough in the three models.",
+    "bbox": [
+      [
+        149,
+        409,
+        848,
+        572
+      ]
+    ],
+    "page_idx": 23
+  }
+]

0d52f34ef10080a11c8fa1ec39fd540697528a60223e57f19842ced1e8fac875/peer_review/images_list.json

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+[
+  {
+    "type": "image",
+    "img_path": "images/Figure_1.jpg",
+    "caption": "Figure 1: Correlation between LC-MS-based metabolites and PICRUSt-based predicted pathway abundances during CRS in the 38 MM validation cohort. Significance was tested by Spearman correlation analysis. Correlations with \\(\\mathrm{FDR}< 0.05\\) were retained. Red and blue color indicate positive and negative correlations, respectively. \\\\* FDR \\(< 0.05\\) , \\\\*\\\\* FDR \\(< 0.01\\) , \\\\*\\\\*\\\\* FDR \\(< 0.001\\)",
+    "bbox": [],
+    "page_idx": 0
+  }
+]

0d761a344627274338024255ac358f7f20d56388e4eb404470a347e836c0ccb4/peer_review/images_list.json

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0d7d2cd2805335e1fb1e3a2db9fd2349893967656b3ca98472b14670c3487516/peer_review/images_list.json

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+[
+  {
+    "type": "image",
+    "img_path": "images/Figure_5.jpg",
+    "caption": "o Figure 5 heatmaps show poor resolution.",
+    "bbox": [
+      [
+        113,
+        88,
+        882,
+        340
+      ]
+    ],
+    "page_idx": 9
+  }
+]

0d84d302744e3647ca6b8589491799090bf8c5dc68e3598a4832926b3bb6e3f0/peer_review/images_list.json

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+[
+  {
+    "type": "image",
+    "img_path": "images/Figure_1.jpg",
+    "caption": "Fig. 1 Time course of expression of SFN and p21, and nuclear translocation of p53.",
+    "bbox": [
+      [
+        234,
+        160,
+        695,
+        373
+      ]
+    ],
+    "page_idx": 8
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0d9faad1160c0f0c31bda08195a7538d5b49e95796b520f3e856ec1ae8735ca9/peer_review/images_list.json

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+[
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_0.jpg",
+    "caption": "Figure R1. Illustration of the strategy of disperse microsize COF sample to nanosize COF sample via sonication.",
+    "bbox": [],
+    "page_idx": 0
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_1.jpg",
+    "caption": "Figure R2. Temperature changes in the control, COF-818 and COF-919 samples under 808 or \\(660 \\mathrm{nm}\\) laser irradiation.",
+    "bbox": [
+      [
+        398,
+        338,
+        595,
+        450
+      ]
+    ],
+    "page_idx": 3
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_2.jpg",
+    "caption": "Figure R3. Western blot results of representative ferroptosis factors, including GPX4, TFRC and xCT in 4T1 cells treated under different conditions.",
+    "bbox": [
+      [
+        305,
+        660,
+        692,
+        860
+      ]
+    ],
+    "page_idx": 4
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_3.jpg",
+    "caption": "Figure R4. IVIS imaging of 4T1 tumor-bearing mouse after injected with COF sample for different times.",
+    "bbox": [
+      [
+        305,
+        392,
+        692,
+        494
+      ]
+    ],
+    "page_idx": 4
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_4.jpg",
+    "caption": "Figure R5. The in vitro and in vivo bioimaging of COF-919.",
+    "bbox": [
+      [
+        256,
+        513,
+        735,
+        754
+      ]
+    ],
+    "page_idx": 5
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_5.jpg",
+    "caption": "Figure R6. The UV-Vis spectra, fluorescence spectra, and Stokes shift of monomers, including M-TPy, M-TPh, and M-TPA.",
+    "bbox": [
+      [
+        160,
+        260,
+        833,
+        399
+      ]
+    ],
+    "page_idx": 8
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_6.jpg",
+    "caption": "Figure R7. Illustration of the different configuration between COF-818 and COF-919.",
+    "bbox": [
+      [
+        301,
+        404,
+        694,
+        628
+      ]
+    ],
+    "page_idx": 9
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_7.jpg",
+    "caption": "Figure R8. The UV-Vis spectra, fluorescence spectra, and Stokes shift of COF-818 and COF-919.",
+    "bbox": [
+      [
+        306,
+        187,
+        691,
+        303
+      ]
+    ],
+    "page_idx": 10
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_8.jpg",
+    "caption": "Figure R5. The in vitro and in vivo bioimaging of COF-919.",
+    "bbox": [
+      [
+        256,
+        536,
+        735,
+        781
+      ]
+    ],
+    "page_idx": 11
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_9.jpg",
+    "caption": "Figure R9. Photoluminescence (PL) spectra of COF-818 (A) and COF-919 (C) in THF/H2O solutions with different water fractions \\((f_{\\mathrm{w}})\\) . (C) Plots of the relative emission intensity (I/I0) of COF-818 and COF-919 versus increased water fraction.",
+    "bbox": [
+      [
+        210,
+        381,
+        787,
+        496
+      ]
+    ],
+    "page_idx": 11
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_10.jpg",
+    "caption": "Figure R10. \\(\\mathrm{IC}_{50}\\) value of 4T1 cells treated with COF-818 and COF-919 at different concentrations under \\(660 \\mathrm{nm}\\) and/or \\(808 \\mathrm{nm}\\) laser irradiation.",
+    "bbox": [
+      [
+        259,
+        335,
+        736,
+        584
+      ]
+    ],
+    "page_idx": 12
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_11.jpg",
+    "caption": "Figure R1. Illustration of the strategy of disperse microsize COF sample to nanosize COF sample vis sonication.",
+    "bbox": [
+      [
+        250,
+        476,
+        737,
+        618
+      ]
+    ],
+    "page_idx": 13
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_12.jpg",
+    "caption": "Figure R11. MTT assay of the viability of 4T1 cells treated with COF-818 and COF-919 at different concentrations under \\(660~\\mathrm{nm}\\) and/or \\(808~\\mathrm{nm}\\) laser irradiation.",
+    "bbox": [
+      [
+        295,
+        81,
+        700,
+        288
+      ]
+    ],
+    "page_idx": 14
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_13.jpg",
+    "caption": "Figure R12. MTT assay of the viability of 4T1 cells treated with PBS, PBS + \\(660~\\mathrm{nm}\\) , PBS + \\(808~\\mathrm{nm}\\) , and PBS + \\(660 + 808~\\mathrm{nm}\\) laser.",
+    "bbox": [
+      [
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+        620,
+        725
+      ]
+    ],
+    "page_idx": 15
+  }
+]

0dfca8da50fdbbca7658136bc95928fa3678a29b12b79ef1499816d98b6a8374/peer_review/images_list.json

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+[
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_0.jpg",
+    "caption": "Figure S10. PLQE of perovskite films, simulated as a function of excitation fluence at a range of Fermi level positions a) with no trap-assisted recombination and b) with trap-assisted recombination.\"",
+    "bbox": [],
+    "page_idx": 10
+  }
+]

0e1902d9b362bf87da2f4c01091362768c84791f9a3091efa963dfe66addc35b/peer_review/images_list.json

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0e25488f7b95134ea96cc13b4efe627cfcc283b44c5a358fb3afba7bef76d499/peer_review/images_list.json

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+[
+  {
+    "type": "image",
+    "img_path": "images/Figure_4.jpg",
+    "caption": "FIGURE 4. Heat map for SiRHP HDX and SAXS modeling. HDX shows that the N terminus of SiRHP is buried in the SiR complex. A, sequence of SiRHP in which light-to-dark blue shows increasingly buried residues and pink-to-red shows increasingly exposed residues, measured by the absolute deuterium uptake. Leu-80 is in boldface type.",
+    "bbox": [
+      [
+        150,
+        115,
+        861,
+        315
+      ]
+    ],
+    "page_idx": 10
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_8.jpg",
+    "caption": "FIGURE 8. HDX of SiRFP. A, sequence of SiRFP, in which light-to-dark blue shows increasingly buried residues and pink-to-red shows increasingly exposed residues. Alternating italic and Roman type denotes domains (amino acids 1–60 make up the N-terminal octomerization domain, amino acids 61–207 make up the FMN domain, amino acids 208–443 make up the FAD domain, and amino acids 444–599 make up the C-terminal NADPH domain). (colors as in 4A).",
+    "bbox": [
+      [
+        133,
+        400,
+        870,
+        590
+      ]
+    ],
+    "page_idx": 10
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_6.jpg",
+    "caption": "FIGURE 6. Functional analysis SiRHP truncations. A, schematic of the SiRHP domains showing the variable N terminus, the first S/NiRR (9), and a short linker followed by a second S/NiRR. B, SiRHP complementation assay of cysI- E. coli (14) transformed with SiRHP-expressing pBAD, empty pBAD, \\(\\Delta 60\\) -SiRHP-expressing pBAD, or \\(\\Delta 80\\) -expressing pBAD vectors grown on minimal M9 (35) or complete LB medium as a positive control. Only wild-type SiRHP expression can complement for growth. C, SEC analysis of SiRHP (red), SiRFP (blue), and SiR (green) show the relative sizes of the complex and its components. D, when SiRFP and excess SiRHP are mixed to ensure complete complex formation, all SiRFP shifts into a higher molecular weight complex, consistent with the size of SiR (purple, solid line). When SiRFP and excess \\(\\Delta 60\\) SiRHP are mixed, the peaks remain consistent with SiRFP and a slightly smaller SiRHP (purple, dashed lines). When SiRFP and \\(\\Delta 80\\) are mixed, the peaks remain consistent with SiRFP and an even smaller SiRHP (purple, dotted lines). mAU, millibarsorbance units.",
+    "bbox": [
+      [
+        150,
+        113,
+        848,
+        404
+      ]
+    ],
+    "page_idx": 11
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_9.jpg",
+    "caption": "FIGURE 9. SEC analysis of SiRFP truncations and Apo-SiRHP. A, SiRHP was mixed with C-terminally truncated SiRFP, an octomer of the FMN domains (SiRFPMM). No higher-order structure was formed, indicating that the patch of amino acids 93-110 is not sufficient for forming a tight complex with SiRHP. Inset, UV-visible spectroscopy shows that SiRFPMM binds flavin cofactor. B, SiRHP was mixed with N-terminally truncated SiRFP, a monomer of the FAD and NADPH domains (SiRFP). A larger complex of higher molecular weight appears, indicating that the patch of amino acids 496-502 is sufficient for forming a tight complex. Inset, UV-visible spectroscopy shows that SiRFPMM binds flavin cofactor, and SiRHP/SiRFPMM shows a spectrum similar to that of SiR holoenzyme (Fig. 1A). C, wild-type SiRHP and \\(\\Delta 80\\) -SiRHP run on SEC as tight peaks, corresponding to monomers of \\(\\sim 64\\) kDa that differ slightly in size because of the N-terminal 80-amino acid truncation in \\(\\Delta 80\\) -SiRHP. D, apo-SiRHP and apo-\\(\\Delta 80\\) -SiRHP run at positions significantly different from those of their metallated counterparts because apo-SiRHP is a homotetramer, whereas apo-\\(\\Delta 80\\) -SiRHP is a monomer. Both are broad, shouldered peaks indicative of loosely packed protein.",
+    "bbox": [
+      [
+        246,
+        519,
+        750,
+        770
+      ]
+    ],
+    "page_idx": 11
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_0.jpg",
+    "caption": "Fig. S9. The SiRFP-60 Fld domain is mobile: a Each position was determined by cryo-EM (this study, showing the most extreme positions from the SiRFP-60/ SiRHP species of structures), X-ray crystallography<sup>4</sup>, or SANS<sup>5</sup>. The position of the Fld domain is dependent on the SiRFP oxidation state or SiRHP binding. b When SiRFP-60 is crystallized, the Fld domain is not ordered although it is present<sup>6</sup>, leaving large solvent channels that can accommodate the positions of the Fld domain captured by SANS<sup>5</sup>, X-ray crystallography of SiRFP-60Δ<sup>4</sup>, or cryo-EM of SiRFP-60/ SiRHP. c Another SiRFP-60 crystal form<sup>6</sup> has solvent channels that accommodate the Fld domain in some positions. b and c are oriented 90° to the left around a vertical axis from where they are positioned in a and colored the same. SiRHP is only present in the cryo-EM structure. d The Fld domain can adopt positions along an elliptical cone shape relative to the FNR domain, accommodated in the channels from the crystal form shown in b (rotated 90° to the left and out of the page relative to b). e SiRFP-60Δ is shown with the FNR domain in a common position to demonstrate the different orientations of the Fld domain. The linker is not visible in this cryo-EM reconstruction. The most extreme closed or open positions of the Fld domain are shown. The closed position is similar to that seen in SiRFP-60X/SiRHP.",
+    "bbox": [],
+    "page_idx": 14
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_1.jpg",
+    "caption": "Fig S1. The SiRFP variants studied here do not complement SiRFP-deficient E. coli under reduced-sulfur growth conditions.",
+    "bbox": [
+      [
+        130,
+        301,
+        808,
+        590
+      ]
+    ],
+    "page_idx": 17
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_2.jpg",
+    "caption": "Fig. S8. The loop that contains h-Lys73 differs in both a sequence (structure-based sequence alignment in UCSF Chimera<sup>1</sup>) and \\(\\mathbf{b}\\) structure, amongst diflavin-reductase (sky blue) dependent hemoprotein (like in \\(E\\) coli, mauve) and ferredoxin (light pink) dependent (like in Z. mays, cornflower blue, S. oleracea, dark yellow, or M. tuberculosis, dark pink). ZmFd and SiRFP have been removed in the inset for clarity. N-terminus of ecSiRHP is dark blue, zmSIR is yellow, soSiRHP is light yellow, and mtSir is peach. c The N-terminus of SiRHP is not strongly conserved in comparison to the active site amino acids, as calculated in UCSF Chimera<sup>1</sup>.",
+    "bbox": [
+      [
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+        48,
+        720,
+        660
+      ]
+    ],
+    "page_idx": 18
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_1.jpg",
+    "caption": "Figure 1: SiR components are highly modular. a SiRFP is composed of an N-terminal octamerization domain (not present in the constructs studied here), an FMN-binding Fld domain (pink) connected through a linker (purple) to an FAD-binding FNR domain (blue) interrupted by a connection (cnxn) domain (light blue). The variants and their names are denoted below: SiRFP-60X has a truncated octamerization domain (*) to make a 60 kDa monomer with engineered crosslinks between the Fld and FNR domain and a full-length linker. SiRFP-60Δ has a truncated octamerization domain (*) to make a 60 kDa monomer with a shortened linker (**, Δ212-217). SiRFP-43 only contains the FNR and connection domains to make a 43 kDa monomer. b SiRHP's N-terminal 80 amino acids (dark blue) are solely responsible for forming a stable interaction with the FNR domain of SiRFP. The pseudosymmetric core is composed of sequential S/NiRRs (green and light green, domains 1/2 and 1'/3) that include a parachute domain (green, domains 1/1').",
+    "bbox": [
+      [
+        113,
+        558,
+        519,
+        900
+      ]
+    ],
+    "page_idx": 20
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_3.jpg",
+    "caption": "Fig S5. SiRFP-60X/SiRHP high resolution map (2.78 Å) with placed co-enzymes: a FAD (contour level 0.5), b FMN (contour level 0.3), c Siroheme-Fe4S4 cluster bound to a distal phosphate with the bridging h-Cys483 (contour level 0.8).",
+    "bbox": [
+      [
+        135,
+        585,
+        827,
+        840
+      ]
+    ],
+    "page_idx": 21
+  }
+]

0e32d155f6317a62a891efa17fc4b06fe2849be5681a1bd4489fb58b15d0c412/peer_review/images_list.json

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+    "type": "image",
+    "img_path": "images/Figure_unknown_0.jpg",
+    "caption": "Fig. R1. The \\(\\mathrm{RuCl}_3\\) and \\(\\mathrm{CuCl}_2\\) nanocrystals are supported by NGA.",
+    "bbox": [
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+        237,
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+    "page_idx": 7
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_1.jpg",
+    "caption": "Fig. R2. The Characterizations of FeCu DAs/NGA. (a) A TEM image of FeCu DAs/NGA. (b) The images of HAADF-STEM and (c) the EDS mapping results (C, N, Fe, Cu). (d) An image of HAADF-STEM for Fe-Cu pair atoms. (e) The frequency of single sites and Fe-Cu dual sites. (f) The distance frequency between adjacent Cu and Fe atoms.",
+    "bbox": [
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+    "page_idx": 9
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_2.jpg",
+    "caption": "Fig. R4. The Characterizations of NiCu DAs/NGA. (a) A TEM image of NiCu DAs/NGA. (b) The images of HAADF-STEM and (c) the EDS mapping results (C, N, Ni, Cu). (d) An image of HAADF-STEM for Ni-Cu pair atoms. (e) The frequency of single sites and Ni-Cu dual sites. (f) The distance frequency between adjacent Cu and Ni atoms.",
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+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_3.jpg",
+    "caption": "Fig. R5. The elements analysis of RuCu DAs/NGA by EDS and XPS. (a) The content curve of each element was scanned in the EDS mapping. (b) The XPS spectra for the survey scan.",
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+    "page_idx": 10
+  },
+  {
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+    "img_path": "images/Figure_unknown_4.jpg",
+    "caption": "Fig. R6. The evolution process of intermediates from \\(\\mathrm{NO}_3\\) to \\(\\mathrm{NH}_3\\) product on the \\(\\mathrm{RuN}_2\\) - \\(\\mathrm{CuN}_3 / \\mathrm{C}\\) structure (top view). (a) \\(\\mathrm{RuN}_2\\mathrm{CuN}_3 / \\mathrm{C}\\) . The Ru-Cu atom pairs absorbed the different",
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+    "img_path": "images/Figure_unknown_5.jpg",
+    "caption": "Fig. R7. The evolution process of intermediates from \\(NO_3\\) to \\(NH_3\\) product on the RuN2-CuN3/C structure (side view). (a) RuN2CuN3/C. The Ru-Cu atom pairs absorbed the different reaction intermediates: (b) \\(*NO_3\\) , (c) \\(*HNO_3\\) , (d) \\(*NO_2\\) , (e) \\(*NOOH\\) , (f) \\(*NO\\) , (g) \\(*NOH\\) , (h) \\(*NHOH\\) , (i) \\(*NH_2OH\\) , (j) \\(*NH_2\\) , (k) \\(*NH_3\\) .",
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+  {
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+    "img_path": "images/Figure_unknown_6.jpg",
+    "caption": "Fig. R8. The characterizations of Cu SAs-DAs/NGA and Ru SAs-DAs/NGA prepared by pulsed discharge. (a) The HAADF-STEM image of Ru SAs-DAs/NGA. (b) The frequency of single Ru sites and Ru-Ru dual sites. (c) The HAADF-STEM image of Cu SAs-DAs/NGA. (d) The frequency of single Cu sites and Cu-Cu dual sites.",
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+    "img_path": "images/Figure_unknown_7.jpg",
+    "caption": "Fig. R9. Ru K-edge and Cu K-edge XAFS results of Ru SAs-DAs/NGA and Cu SAs-DAs/NGA. Cu K-edge XAFS results of Cu SAs-DAs/NGA: (a) XANES results. (b) EXAFS results. (c) The fitting of R space result. (d) The fitting of q space. (e) The fitting of k space result. (f) The WT-EXAFS result. Ru K-edge XAFS results of Ru SAs-DAs/NGA: (a) XANES results.",
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+    "caption": "Fig. R10. NO3RR performance results of RuCu DAs/NGA, Cu SAs-DAs/NGA, mixture of Cu SAs-DAs/NGA and Ru SAs-DAs/NGA, and Ru SAs-DAs/NGA. (a) LSV curves of RuCu DAs/NGA, Ru SAs-DAs/NGA, the mixture of Cu SAs-DAs/NGA and Ru SAs-DAs/NGA, and Cu SAs-DAs/NGA, measured in 0.1 M KNO3 and 0.1 M KOH electrolyte. (b) The FEs of NH3 production at varied potentials. (c) Partial NH3 current densities of three catalysts at different potentials. (d) The potential-dependent yield rate of NH3 generation.",
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+    "img_path": "images/Figure_unknown_9.jpg",
+    "caption": "Fig. R11. The contribution analysis of single sites. (a) The HAADF-STEM image of \\(\\mathrm{Ru}_{17\\%}\\) SAs/NGA. (b) The HAADF-STEM image of \\(\\mathrm{Cu}_{17\\%}\\) SAs/NGA. (c) LSV curves of \\(\\mathrm{RuCu}\\) DAs/NGA and the mixture catalysts of \\(\\mathrm{Ru}_{17\\%}\\) SAs/NGA and \\(\\mathrm{Cu}_{17\\%}\\) SAs/NGA measured in 0.1 M \\(\\mathrm{KNO}_3\\) and 0.1 M KOH electrolyte. (d) The FEs of \\(\\mathrm{NH}_3\\) production in different potentials. (e) The yield rate of \\(\\mathrm{NH}_3\\) production in different potentials.",
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+    "img_path": "images/Figure_unknown_10.jpg",
+    "caption": "Fig. R12. The 24 h long-term tests of RuCu DAs/NGA during NO₃RR at -0.4 V vs. RHE.",
+    "bbox": [
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+    "page_idx": 23
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+    "img_path": "images/Figure_unknown_11.jpg",
+    "caption": "Fig. R13. The characterizations of RuCu DAs/NGA. (a) The HAADF-STEM image of RuCu DAs/NGA after the NO₃RR stability test. (b) The local magnified image of RuCu DAs/NGA. (c) The distance frequency between adjacent Cu and Ru atoms, and the frequency of single sites and Ru-Cu dual sites.",
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+    "page_idx": 26
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+    "img_path": "images/Figure_unknown_12.jpg",
+    "caption": "Fig. R14. Cu K-edge XAFS results of RuCu DAs/NGA after \\(\\mathrm{NO}_3\\mathrm{RR}\\) stability test. (a) XANES results before and after the test. (b) EXAFS results before and after the test. (c) The fitting of R",
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+    "page_idx": 27
+  },
+  {
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+    "img_path": "images/Figure_unknown_13.jpg",
+    "caption": "Fig. R15. Ru K-edge XAFS results of RuCu DAs/NGA after \\(\\mathbf{NO}_3\\) RR stability test. (a) XANES results before and after the test. (b) EXAFS results before and after the test. (c) The fitting of R space results after the test. (d) The fitting of q space result after the test. (e) The fitting of k space result after the test. (f) The WT-EXAFS result after the test.",
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+    "page_idx": 28
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+  {
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+    "img_path": "images/Figure_unknown_14.jpg",
+    "caption": "Fig. R16. The process of temperature and total energy by AIMD.",
+    "bbox": [
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+    "page_idx": 29
+  },
+  {
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+    "img_path": "images/Figure_unknown_15.jpg",
+    "caption": "Fig. R17. The structure variation of RuCu DAs/NGA from 2-10 ps.",
+    "bbox": [
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+    "page_idx": 31
+  },
+  {
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+    "img_path": "images/Figure_unknown_16.jpg",
+    "caption": "Fig. R18. In situ XAFS results of RuCu DAs/NGA. (a) Cu and (b) Ru K-edge XANES spectra of RuCu DAs/NGA at different applied potentials (OCP, -0.1 V, -0.2 V, -0.3 V, -0.4 V, and -0.5 V) during the NO₃RR process. (c) The valence states of Cu and Ru in RuCu DAs/NGA and references based on the first-order derivative of XANES spectra. (d) Cu and (e) Ru K-edge k³-weighted FT-EXAFS at different potentials during the NO₃RR process.",
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+    "page_idx": 32
+  },
+  {
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+    "img_path": "images/Figure_unknown_17.jpg",
+    "caption": "Fig. R19. The 24 h long-term tests of RuCu DAs/NGA during NO₃RR at -0.4 V vs. RHE.",
+    "bbox": [
+      [
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+    ],
+    "page_idx": 34
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_18.jpg",
+    "caption": "Fig. R20. The characterizations of RuCu DAs/NGA. (a) The HAADF-STEM image of RuCu DAs/NGA after the NO₃RR stability test. (b) The local magnified image of RuCu DAs/NGA. (c) The distance frequency between adjacent Cu and Ru atoms, and the frequency of single sites and Ru-Cu dual sites.",
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+    ],
+    "page_idx": 42
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_19.jpg",
+    "caption": "Fig. R21. Cu K-edge XAFS results of RuCu DAs/NGA after NO₃RR stability test. (a) XANES results before and after the test. (b) EXAFS results before and after the test. (c) The fitting of R",
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+    "page_idx": 43
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_20.jpg",
+    "caption": "Fig. R22. Ru K-edge XAFS results of RuCu DAs/NGA after \\(\\mathbf{NO}_3\\) RR stability test. (a) XANES results before and after the test. (b) EXAFS results before and after the test. (c) The fitting of R space results after the test. (d) The fitting of q space result after the test. (e) The fitting of k space result after the test. (f) The WT-EXAFS result after the test.",
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+        500
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+    "page_idx": 44
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_21.jpg",
+    "caption": "Fig. R23. The process of temperature and total energy by AIMD.",
+    "bbox": [
+      [
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+        228,
+        714,
+        465
+      ]
+    ],
+    "page_idx": 45
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_22.jpg",
+    "caption": "Fig. R24. The structure variation of RuCu DAs/NGA from 2-10 ps.",
+    "bbox": [
+      [
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+        87,
+        880,
+        555
+      ]
+    ],
+    "page_idx": 47
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_23.jpg",
+    "caption": "Fig. R25. The analysis of the formation mechanism of Ru-Cu atom pairs. (a) A TEM image of initial \\(\\mathrm{CuCl_2 - RuCl_3 / NGA}\\) . (b) and (c) The HAADF-STEM images of \\(\\mathrm{CuCl_2 - RuCl_3 / NGA}\\) after 2nd pulsed discharge. (d) and (e) The HAADF-STEM images of \\(\\mathrm{CuCl_2 - RuCl_3 / NGA}\\) after 4th pulsed discharge. (f) The HAADF-STEM image of \\(\\mathrm{CuCl_2 - RuCl_3 / NGA}\\) after 6th pulsed discharge.",
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+    "page_idx": 48
+  },
+  {
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+    "img_path": "images/Figure_unknown_24.jpg",
+    "caption": "Fig. R26. A simplified passive two-terminal network model for pulsed discharge system.",
+    "bbox": [
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+        761
+      ]
+    ],
+    "page_idx": 52
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_25.jpg",
+    "caption": "Fig. R28. An observational experiment for pulsed discharge using a high-speed camera. (a) 0 μs. (b) 10 μs. (c) 20 μs. (d) 30 μs. (e) 40 μs. (f) 50 μs.",
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+    "page_idx": 54
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_26.jpg",
+    "caption": "Fig. R29. Simulation analysis of the pulsed discharge process. (a) SEM image of RuCu DAs/NGA. (b) The simplified equivalent circuit. (c) The current-voltage curve from the discharge experiment with the copper tube containing samples. (d-h) The simulation results of a graphene layer during joule heating. (i) A temperature raise curve on graphene during joule heating.",
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+    ],
+    "page_idx": 56
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_27.jpg",
+    "caption": "Fig. R30. The contribution analysis of single sites. (a) The HAADF-STEM image of \\(\\mathrm{Ru}_{17\\%}\\) SAs/NGA. (b) The HAADF-STEM image of \\(\\mathrm{Cu}_{17\\%}\\) SAs/NGA. (c) LSV curves of \\(\\mathrm{RuCu}\\) DAs/NGA and the mixture catalysts of \\(\\mathrm{Ru}_{17\\%}\\) SAs/NGA and \\(\\mathrm{Cu}_{17\\%}\\) SAs/NGA measured in 0.1 M \\(\\mathrm{KNO}_3\\) and 0.1 M KOH electrolyte. (d) The FEs of \\(\\mathrm{NH}_3\\) production in different potentials. (e) The yield rate of \\(\\mathrm{NH}_3\\) production in different potentials.",
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+      ]
+    ],
+    "page_idx": 57
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_28.jpg",
+    "caption": "Fig. R31. The characterizations of Cu SAs-DAs/NGA prepared by pulsed discharge. (a) The HAADF-STEM image of Cu SAs-DAs/NGA. (b) The frequency of single Cu sites and Cu-Cu dual sites.",
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+        422
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+    ],
+    "page_idx": 59
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_29.jpg",
+    "caption": "Fig. R32. The characterizations of Ru SAs-DAs/NGA prepared by pulsed discharge. (a) The HAADF-STEM image of Ru SAs-DAs/NGA. (b) The frequency of single Ru sites and Ru-Ru dual sites.",
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+      [
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+      ]
+    ],
+    "page_idx": 62
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_30.jpg",
+    "caption": "Fig. R33. Cu K-edge XAFS results of Cu SAs-DAs/NGA prepared by pulsed discharge. (a) XANES results. (b) EXAFS results. (c) The fitting of R space result. (d) The fitting of q space. (e) The fitting of k space result. (f) The WT-EXAFS result.",
+    "bbox": [
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+        415
+      ]
+    ],
+    "page_idx": 65
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_31.jpg",
+    "caption": "Fig. R34. Ru K-edge XAFS results of Ru SAs-DAs/NGA prepared by pulsed discharge. (a) XANES results. (b) EXAFS results. (c) The fitting of R space result. (d) The fitting of q space. (e) The fitting of k space result. (f) The WT-EXAFS result.",
+    "bbox": [
+      [
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+        92,
+        850,
+        410
+      ]
+    ],
+    "page_idx": 66
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_32.jpg",
+    "caption": "Fig. R35. \\(\\mathrm{NO_3RR}\\) performance results of RuCu DAs/NGA, Cu SAs-DAs/NGA, and Ru SAs-DAs/NGA. (a) LSV curves of RuCu DAs/NGA, Ru SAs-DAs/NGA, and Cu SAs-DAs/NGA, measured in 0.1 M \\(\\mathrm{KNO_3}\\) and 0.1 M KOH electrolyte. (b) The FEs of \\(\\mathrm{NH_3}\\) production at varied potentials. (c) Partial \\(\\mathrm{NH_3}\\) current densities of three catalysts at different potentials. (d) The potential-dependent yield rate of \\(\\mathrm{NH_3}\\) generation.",
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+    ],
+    "page_idx": 67
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_33.jpg",
+    "caption": "Fig. R36. The compression stress-strain curves of NGA and RuCu DAs/NGA.",
+    "bbox": [
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+        352
+      ]
+    ],
+    "page_idx": 68
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_34.jpg",
+    "caption": "Fig. R37. \\(^{1}\\mathrm{H}\\) nuclear magnetic resonance (NMR) analysis for ammonia production. The \\(^{1}\\mathrm{H}\\) NMR spectrum of the product was obtained by electroreduction of \\(^{14}\\mathrm{N}\\) nitrate and \\(^{15}\\mathrm{N}\\) nitrate.",
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+    ],
+    "page_idx": 70
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_35.jpg",
+    "caption": "Fig. R38. LSV curves of NGA and NGA after pulsed discharge measured in 0.1 M KNO<sub>3</sub> and 0.1 M KOH electrolyte.",
+    "bbox": [
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+    ],
+    "page_idx": 73
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_36.jpg",
+    "caption": "Fig. R39. The tests of \\(\\mathrm{NO_3RR}\\) for RuCu DAs/NGA in different \\(\\mathrm{KNO_3}\\) concentrations and 0.1 M KOH electrolyte. (a) LSV curves of RuCu DAs/NGA. (b) The FEs of \\(\\mathrm{NH_3}\\) production at different potentials. (b) The yield rate of \\(\\mathrm{NH_3}\\) production at different potentials.",
+    "bbox": [
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+        345
+      ]
+    ],
+    "page_idx": 75
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_37.jpg",
+    "caption": "Fig. R40. The HAADF-STEM images of RuCu Clu/NGA were prepared by pulsed discharge on \\(9\\mathrm{kV}\\) . (a) An image at low magnification and (b) at high magnification.",
+    "bbox": [
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+    ],
+    "page_idx": 78
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_38.jpg",
+    "caption": "Fig. R41. Cu K-edge XAFS results of RuCu Clu/NGA (9kV) prepared by pulsed discharge.",
+    "bbox": [
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+    ],
+    "page_idx": 80
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_39.jpg",
+    "caption": "Fig. R42. Ru K-edge XAFS results of RuCu Clu/NGA (9kV) prepared by the pulsed discharge. (a) XANES results. (b) EXAFS results. (c) The fitting of R space result. (d) The fitting of q space. (e) The fitting of k space result. (f) The WT-EXAFS result.",
+    "bbox": [
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+        413
+      ]
+    ],
+    "page_idx": 82
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_40.jpg",
+    "caption": "Fig. R43. The HAADF-STEM images of (a) Ru<sub>1</sub>Cu<sub>2</sub> Clu/NGA and (b) Ru<sub>2</sub>Cu<sub>1</sub> Clu/NGA were prepared by pulsed discharge.",
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+    ],
+    "page_idx": 83
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_41.jpg",
+    "caption": "Fig. R44. Cu K-edge XAFS results of \\(\\mathbf{Cu}_{1}\\mathbf{Ru}_{2}\\) Clu/NGA prepared by pulsed discharge. (a) XANES results. (b) EXAFS results. (c) The fitting of R space result. (d) The fitting of q space. (e) The fitting of k space result. (f) The WT-EXAFS result.",
+    "bbox": [
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+        415
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+    ],
+    "page_idx": 84
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_42.jpg",
+    "caption": "Fig. R45. Ru K-edge XAFS results of \\(\\mathrm{Cu_1Ru_2}\\) Clu/NGA prepared by pulsed discharge. (a) XANES results. (b) EXAFS results. (c) The fitting of R space result. (d) The fitting of q space. (e) The fitting of k space result. (f) The WT-EXAFS result.",
+    "bbox": [
+      [
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+        850,
+        415
+      ]
+    ],
+    "page_idx": 86
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_43.jpg",
+    "caption": "Fig. R46. Cu K-edge XAFS results of \\(\\mathbf{Cu}_{2}\\mathbf{Ru}_{1}\\) Clu/NGA prepared by pulsed discharge. (a) XANES results. (b) EXAFS results. (c) The fitting of R space result. (d) The fitting of q space. (e) The fitting of k space result. (f) The WT-EXAFS result.",
+    "bbox": [
+      [
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+        95,
+        848,
+        410
+      ]
+    ],
+    "page_idx": 87
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_44.jpg",
+    "caption": "Fig. R47. Ru K-edge XAFS results of \\(\\mathbf{Cu}_2\\mathbf{Ru}_1\\) Clu/NGA prepared by pulsed discharge. (a) XANES results. (b) EXAFS results. (c) The fitting of R space result. (d) The fitting of q space. (e) The fitting of k space result. (f) The WT-EXAFS result.",
+    "bbox": [
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+    "caption": "Fig. R48. The tests of \\(\\mathrm{NO_3RR}\\) for RuCu DAs/NGA, \\(\\mathrm{Ru_2Cu_1}\\) Clu/NGA, \\(\\mathrm{Ru_1Cu_2}\\) Clu/NGA, and RuCu Clu/NGA (9 kV) in 0.1 M \\(\\mathrm{KNO_3}\\) and 0.1 M KOH electrolyte. (a) LSV curves of RuCu DAs/NGA, \\(\\mathrm{Ru_2Cu_1}\\) Clu/NGA, \\(\\mathrm{Ru_1Cu_2}\\) Clu/NGA, and RuCu Clu/NGA (9 kV). (b) The FEs of \\(\\mathrm{NH_3}\\) production in different potentials. (c) The yield rate of \\(\\mathrm{NH_3}\\) production in different potentials.",
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+    "caption": "Fig. R49. The tests of \\(\\mathrm{NO}_3\\mathrm{RR}\\) for RuCu DAs/NGA in different \\(\\mathrm{KNO}_3\\) concentrations (1 mM, 2 mM, and 10 mM) and 0.1 M KOH electrolyte. (a) LSV curves of RuCu DAs/NGA. (b) The FEs of \\(\\mathrm{NH}_3\\) production at different potentials. (b) The yield rate and FE of \\(\\mathrm{NH}_3\\) generation for RuCu DAs/NGA at different \\(\\mathrm{NO}_3\\) concentrations (-0.4 V vs. RHE). (c) The yield rate and FE of \\(\\mathrm{NH}_3\\) generation for RuCu DAs/NGA at different \\(\\mathrm{NO}_3\\) concentrations (-0.5 V vs. RHE).",
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+    "caption": "Fig. R50. The STEM-EELS results of RuCu DAs/NGA. (a) The HAADF-STEM image of RuCu DAs/NGA. (b) EELS result of Cu L edge in Ru/Cu atomic pairs. (c) SI-HAADF image of Ru/Cu atomic pairs. (d) The EELS map image of Cu element. (e) Overlay image of SI-HAADF and EELS Cu map for Ru/Cu atomic pairs.",
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+    "caption": "Fig. R51. The STEM-EELS results of RuCu DAs/NGA. (a) The HAADF-STEM image of RuCu DAs/NGA. (b) EELS result of Cu L edge in Ru/Cu atomic pairs. (c) SI-HAADF image of Ru/Cu atomic pairs. (d) The mapping image of Cu element. (e) Overlay image of SI-HAADF and Cu mapping for Ru/Cu atomic pairs.",
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+    "caption": "Fig. R52. The STEM-EELS results of RuCu DAs/NGA. (a) SI-HAADF image of Ru/Cu atomic pairs. (b) The mapping image of Cu element. (c) Overlay image of SI-HAADF and Cu mapping for Ru/Cu atomic pairs.",
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+    "caption": "Fig. R54. The EELS results for Ru-Cu interatomic interactions analysis. (a-e) The SI-HAADF images of Ru/Cu atomic pairs. (f) Overlay EELS result of (a-e) for Cu L edge in Ru/Cu atomic pairs. (g) The SI-HAADF image of isolated Cu atoms in RuCu DAs/NGA. (h) Overlay EELS result of 12 Cu atoms for Cu L edge in Ru/Cu.",
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+    "img_path": "images/Figure_unknown_51.jpg",
+    "caption": "Fig. R55. The differential charge density of \\(\\mathrm{RuN}_2\\mathrm{CuN}_3 / \\mathrm{C}\\) .",
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+  {
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+    "caption": "Fig. R56. The projected density of states of RuN<sub>2</sub>CuN<sub>3</sub>/C.",
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+    "caption": "Fig. R57. Electrochemical \\(\\mathrm{NO}_3\\mathrm{RR}\\) pathway on \\(\\mathrm{RuN}_2\\mathrm{CuN}_3 / \\mathrm{C}\\) . (a) \\(\\mathrm{RuN}_2\\mathrm{CuN}_3 / \\mathrm{C}\\) . The different reaction intermediates were absorbed by Ru-Cu atom pairs: (b) \\(*\\mathrm{NO}_3\\) , (c) \\(*\\mathrm{HNO}_3\\) , (d) \\(*\\mathrm{NO}_2\\) , (e) \\(*\\mathrm{NOOH}\\) , (f) \\(*\\mathrm{NO}\\) , (g) \\(*\\mathrm{NOH}\\) , (h) \\(*\\mathrm{NHOH}\\) , (i) \\(*\\mathrm{NH}_2\\mathrm{OH}\\) , (j) \\(*\\mathrm{NH}_2\\) , (k) \\(*\\mathrm{NH}_3\\) .",
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+    "caption": "Fig. R58. The characterizations of Cu SAs-DAs/NGA and Ru SAs-DAs/NGA prepared by pulsed discharge. (a) The HAADF-STEM image of Ru SAs-DAs/NGA. (b) The frequency of single Ru sites and Ru-Ru dual sites. (c) The HAADF-STEM image of Cu SAs-DAs/NGA. (d) The frequency of single Cu sites and Cu-Cu dual sites.",
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+    "type": "image",
+    "img_path": "images/Figure_unknown_55.jpg",
+    "caption": "Fig. R59. Ru K-edge and Cu K-edge XAFS results of Ru SAs-DAs/NGA and Cu SAs-DAs/NGA. Cu K-edge XAFS results of Cu SAs-DAs/NGA: (a) XANES results. (b) EXAFS results. (c) The fitting of R space result. (d) The fitting of q space. (e) The fitting of k space result. (f) The WT-EXAFS result. Ru K-edge XAFS results of Ru SAs-DAs/NGA: (a) XANES results.",
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+    "img_path": "images/Figure_unknown_56.jpg",
+    "caption": "Fig. R60. NO3RR performance results of RuCu DAs/NGA, Cu SAs-DAs/NGA, mixture of Cu SAs-DAs/NGA and Ru SAs-DAs/NGA, and Ru SAs-DAs/NGA. (a) LSV curves of RuCu DAs/NGA, Ru SAs-DAs/NGA, the mixture of Cu SAs-DAs/NGA and Ru SAs-DAs/NGA, and Cu SAs-DAs/NGA, measured in 0.1 M KNO3 and 0.1 M KOH electrolyte. (b) The FEs of NH3 production at varied potentials. (c) Partial NH3 current densities of three catalysts at different potentials. (d) The potential-dependent yield rate of NH3 generation.",
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+  {
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+    "img_path": "images/Figure_unknown_57.jpg",
+    "caption": "Fig. R61. The contribution analysis of single sites. (a) The HAADF-STEM image of \\(\\mathrm{Ru}_{17\\%}\\) SAs/NGA. (b) The HAADF-STEM image of \\(\\mathrm{Cu}_{17\\%}\\) SAs/NGA. (c) LSV curves of \\(\\mathrm{RuCu}\\) DAs/NGA and the mixture catalysts of \\(\\mathrm{Ru}_{17\\%}\\) SAs/NGA and \\(\\mathrm{Cu}_{17\\%}\\) SAs/NGA measured in 0.1 M \\(\\mathrm{KNO}_3\\) and 0.1 M KOH electrolyte. (d) The FEs of \\(\\mathrm{NH}_3\\) production in different potentials. (e) The yield rate of \\(\\mathrm{NH}_3\\) production in different potentials.",
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+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_58.jpg",
+    "caption": "Fig. R62. Double-layer capacitance measurements. (a) The representative set of CV scans of RuCu DAs/NGA, (b) Ru SAs-DAs/NGA, and (c) Cu SAs-DAs/NGA. (d) Double-layer charging current plotted against the scan rate for different electrodes.",
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+    ],
+    "page_idx": 113
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_59.jpg",
+    "caption": "Fig. R63. The LSV curves normalized to the ECSA for distinct catalysts.",
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+      ]
+    ],
+    "page_idx": 116
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+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_60.jpg",
+    "caption": "Fig. R65. The Pt \\(L_{3}\\) -edge XANES spectra of PtCu DAs/NGA and the references (Pt foil and PtO2).",
+    "bbox": [],
+    "page_idx": 118
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_61.jpg",
+    "caption": "Fig. R66. The analysis of the formation mechanism of Ru-Cu atom pairs. (a) A TEM image of initial \\(\\mathrm{CuCl_2 - RuCl_3 / NGA}\\) . (b) and (c) The HAADF-STEM images of \\(\\mathrm{CuCl_2 - RuCl_3 / NGA}\\) after 2nd pulsed discharge. (d) and (e) The HAADF-STEM images of \\(\\mathrm{CuRuDAs / NGA}\\) after 4th pulsed discharge. (f) The HAADF-STEM image of \\(\\mathrm{CuCl_2 - RuCl_3 / NGA}\\) after 6th pulsed discharge.",
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+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_62.jpg",
+    "caption": "Fig. R67. HAADF-STEM images and EDS mapping images of RuCu DAs/NGA. (a) HAADF-STEM image of RuCu DAs/NGA. (b) EDS mapping image of C element, (c) N element, (d) Cu element, (e) Ru element.",
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+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_63.jpg",
+    "caption": "Fig. R68. HAADF-STEM images and EDS mapping images of RuCu DAs/NGA. (a) HAADF-STEM image of RuCu DAs/NGA. (b) EDS mapping image of C element, (c) N element, (d) Cu element, (e) Ru element.",
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+    "caption": "Fig. R69. HAADF-STEM images and EDS mapping images of RuCu DAs/NGA. (a) HAADF-STEM image of RuCu DAs/NGA. (b) EDS mapping image of C element, (c) N element, (d) Cu element, (e) Ru element.",
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+    "page_idx": 129
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_65.jpg",
+    "caption": "Fig. R70. HAADF-STEM images and EDS mapping images of RuCu DAs/NGA. (a) HAADF-STEM image of RuCu DAs/NGA. (b) EDS mapping image of C element, (c) N element, (d) Cu element, (e) Ru element.",
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+    "page_idx": 135
+  },
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+    "type": "image",
+    "img_path": "images/Figure_unknown_66.jpg",
+    "caption": "Fig. R71. The chemical state analysis of RuCu DAs/NGA. (a) The XPS spectra of Cu2p and (b) Ru3p of RuCu DAs/NGA. (c) The first derivative curves of Cu K-edge and (d) Ru K-edge XANES absorption edge for RuCu DAs/NGA and references. (e) The valence states of Cu and Ru in RuCu DAs/NGA and references are based on the first-order derivative of XANES spectra. (f) The XPS spectra and fitting results of N1s of RuCu DAs/NGA.",
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+    "page_idx": 138
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+    "type": "image",
+    "img_path": "images/Figure_72.jpg",
+    "caption": "Fig. 72. Atomic coordination structure and chemical state of RuCu DAs/NGA. (a) The Cu K-edge EXAFS fitting result of RuCu DAs/NGA in the R space. (b) The Ru K-edge EXAFS fitting result of RuCu DAs/NGA in the R space. (c) The proposed atomic structure model of RuCu DAs/NGA.",
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+    "page_idx": 139
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+    "caption": "Fig. R73. The process of temperature and total energy.",
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+    "page_idx": 140
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+    "img_path": "images/Figure_unknown_68.jpg",
+    "caption": "Fig. R74. The structure variation of RuCu DAs/NGA from 2-10 ps.",
+    "bbox": [
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+    "page_idx": 141
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+    "caption": "Fig. R75. The STEM-EELS results of RuCu DAs/NGA. (a) The HAADF-STEM image of RuCu DAs/NGA. (b) EELS result of Cu L in Ru/Cu atomic pairs. (c) SI-HAADF image of Ru/Cu atomic pairs. (d) The EELS map image of Cu element. (e) Overlay image of SI-HAADF and EELS Cu map for Ru/Cu atomic pairs.",
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+    "page_idx": 142
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+    "type": "image",
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+    "caption": "Fig. R76. The STEM-EELS results of RuCu DAs/NGA. (a) The HAADF-STEM image of RuCu DAs/NGA. (b) EELS result of Cu L edge in Ru/Cu atomic pairs. (c) SI-HAADF image of Ru/Cu atomic pairs. (d) The mapping image of Cu element. (e) Overlay image of SI-HAADF and Cu mapping for Ru/Cu atomic pairs.",
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+    "page_idx": 143
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+    "caption": "Fig. R77. The STEM-EELS results of RuCu DAs/NGA. (a) SI-HAADF image of Ru/Cu atomic pairs. (b) The mapping image of Cu element. (c) Overlay image of SI-HAADF and Cu mapping for Ru/Cu atomic pairs.",
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+    "caption": "Fig. R78. XANES results of expanded PtCu DAs/NGA and Pt foil and \\(\\mathrm{PtO_2}\\) . (a) The Pt \\(\\mathrm{L_3}\\) - edge XANES spectra of PtCu DAs/NGA and the references (Pt foil and \\(\\mathrm{PtO_2}\\) ). (b) The local enlarged of (a).",
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+    "caption": "Fig. R79. XANES results of expanded PtCu DAs/NGA and Pt foil and PtO2. (a) The Pt L3-edge XANES spectra of PtCu DAs/NGA and the references (Pt foil and PtO2). (b) The normalized difference spectra for Pt L3-edge XANES using Pt foil as reference.",
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+    "caption": "Fig. R80. The XRD results of RuCu DAs/NGA and NGA.",
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+    "caption": "Fig. R81. The Raman results of RuCu DAs/NGA and NGA.",
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+    "caption": "Fig. R82. The XPS results of NGA and RuCu DAs/NGA. (a) The XPS spectra for the survey scan of NGA. (b) The spectra for C1s and (c) N1s of NGA. (d) The XPS spectra for the survey scan of RuCu DAs/NGA. (e) The spectra for C1s and (f) N1s of RuCu DAs/NGA.",
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+    "caption": "Fig. R83. Cu K-edge XAFS results of Cu foil, CuO, CuPc, and RuCu DAs/NGA.",
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+    "caption": "Fig. R84. The content curve of each element was scanned in the EDS mapping.",
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+    "caption": "Fig. R85. The XPS results of RuCu DAs/NGA. (a) The XPS spectra for the survey scan. (b)-(e) The spectra for C1s, N1s, Cu2p, and Ru3p of RuCu DAs/NGA. (f) The contents of C, N, O, Cu, and Ru in RuCu DAs/NGA.",
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+    "caption": "Fig. R86. The STEM-EELS results of RuCu DAs/NGA. (a) The HAADF-STEM image of RuCu DAs/NGA. (b) EELS result of Cu L in Ru/Cu atomic pairs. (c) SI-HAADF image of Ru/Cu atomic pairs. (d) The EELS map image of Cu element. (e) Overlay image of SI-HAADF and EELS Cu map for Ru/Cu atomic pairs.",
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+    "page_idx": 155
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+    "type": "image",
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+    "caption": "Fig. R87. The STEM-EELS results of RuCu DAs/NGA. (a) The HAADF-STEM image of RuCu DAs/NGA. (b) EELS result of Cu L edge in Ru/Cu atomic pairs. (c) SI-HAADF image of Ru/Cu atomic pairs. (d) The mapping image of Cu element. (e) Overlay image of SI-HAADF and Cu mapping for Ru/Cu atomic pairs.",
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+    "caption": "Fig. R88. The STEM-EELS results of RuCu DAs/NGA. (a) SI-HAADF image of Ru/Cu atomic pairs. (b) The mapping image of Cu element. (c) Overlay image of SI-HAADF and Cu mapping for Ru/Cu atomic pairs.",
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+    "caption": "Fig. R89. The tests of \\(\\mathrm{NO_3RR}\\) for RuCu DAs/NGA in different \\(\\mathrm{KNO_3}\\) concentrations and 0.1 M KOH electrolyte. (a) LSV curves of RuCu DAs/NGA. (b) The FEs of \\(\\mathrm{NH_3}\\) production at different potentials. (b) The yield rate of \\(\\mathrm{NH_3}\\) production at different potentials.",
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+    "type": "image",
+    "img_path": "images/Figure_unknown_0.jpg",
+    "caption": "Figure RR1. Comparison of \\(95^{\\text{th}}\\) percentiles for daily mean wet-bulb temperature. The percentiles used in the manuscript are calculated using the \\(95^{\\text{th}}\\) percentile of values in all days and years and are referred to as \"percentiles calculated over all years\". Alternatively, percentiles calculated separately for each of the 30 years and then averaged are referred to as \"percentiles calculated as the mean of annual percentiles\".",
+    "bbox": [
+      [
+        178,
+        228,
+        890,
+        610
+      ]
+    ],
+    "page_idx": 12
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_1.jpg",
+    "caption": "Figure RR2. Heatwave composite time series for daily mean 2m temperatures. The time series run from 7 days before the start of each heatwave (day -7) to 7 days after the start of each heatwave (day 7). Day 0 is the heatwave start day. The number of stations with sufficient data in each rainfall-heatwave regime is shown in the top right of each panel.",
+    "bbox": [
+      [
+        128,
+        88,
+        870,
+        455
+      ]
+    ],
+    "page_idx": 15
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_3a.jpg",
+    "caption": "Figure RR3. Reproduction of Figure 3a in the main manuscript but using daily maximum instead of daily mean wet-bulb temperatures.",
+    "bbox": [
+      [
+        216,
+        576,
+        777,
+        835
+      ]
+    ],
+    "page_idx": 16
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_3.jpg",
+    "caption": "Figure RR4. Heatwave composite time series from 7 days before the start of each heatwave (day -7) to 7 days after the start of each heatwave (day 7). Day 0 is the heatwave start day. Solid lines show daily mean values as presented in Figure 3 of the manuscript (i.e., with no area weighting of grid cells). Crosses show the equivalent values when the grid cells in each regime are area weighted.",
+    "bbox": [
+      [
+        123,
+        272,
+        870,
+        583
+      ]
+    ],
+    "page_idx": 18
+  }
+]

251724f4f1b6c9330b23aa9179b152be8eec0b94e8ee8160694d771411dce499/peer_review/images_list.json

@@ -0,0 +1,331 @@
+[
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_0.jpg",
+    "caption": "Figure S2. HRTEM images of the edges of BIO nanosheets.",
+    "bbox": [
+      [
+        361,
+        727,
+        634,
+        863
+      ]
+    ],
+    "page_idx": 4
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_4.jpg",
+    "caption": "Figure 4. (i) ·OH yield within 20 min in the BF1.5 system under various reaction conditions.",
+    "bbox": [
+      [
+        333,
+        90,
+        666,
+        277
+      ]
+    ],
+    "page_idx": 6
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_1.jpg",
+    "caption": "Figure S26. The ·OH yield of pure water cavitation without catalyst, BF1.5 in pure water/air and BF1.5 in pure water/Ar in sealable reactor.",
+    "bbox": [
+      [
+        330,
+        325,
+        666,
+        513
+      ]
+    ],
+    "page_idx": 6
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_2.jpg",
+    "caption": "Figure S9. (a) UV-vis absorption spectra for different concentration of \\(\\mathrm{H}_2\\mathrm{O}_2\\) and (b) The linear relationship of concentration of \\(\\mathrm{H}_2\\mathrm{O}_2\\) vs. UV-vis absorption intensity.",
+    "bbox": [
+      [
+        220,
+        84,
+        775,
+        248
+      ]
+    ],
+    "page_idx": 7
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_3.jpg",
+    "caption": "Figure S10. Time-dependent UV-vis absorption spectra of \\(\\mathrm{H}_2\\mathrm{O}_2\\) produced by different catalysts.",
+    "bbox": [
+      [
+        245,
+        310,
+        747,
+        600
+      ]
+    ],
+    "page_idx": 7
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_4.jpg",
+    "caption": "Figure S36. Cyclic experiment for RhB degradation by BF1.5-loaded nonwoven fabrics.",
+    "bbox": [
+      [
+        330,
+        391,
+        666,
+        575
+      ]
+    ],
+    "page_idx": 9
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_5.jpg",
+    "caption": "Figure S37. Before and after reaction images of BF1.5-loaded nonwoven fabrics.",
+    "bbox": [
+      [
+        275,
+        608,
+        720,
+        784
+      ]
+    ],
+    "page_idx": 9
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_6.jpg",
+    "caption": "Figure S25. Fe 2p XPS spectra of (a) BF1.5 and (b) used BF1.5 (RBF1.5). (c) Fe 2p XPS spectrum of used BF1.5 in BF1.5-CAT system.",
+    "bbox": [
+      [
+        148,
+        611,
+        850,
+        762
+      ]
+    ],
+    "page_idx": 12
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_7.jpg",
+    "caption": "Figure S19. The total organic carbon of RhB solution at 0 min and 15 min of reaction.",
+    "bbox": [
+      [
+        336,
+        312,
+        664,
+        483
+      ]
+    ],
+    "page_idx": 16
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_8.jpg",
+    "caption": "Figure S20. ESI mass spectra of the degradation of RhB over BF1.5 by LC-MS.",
+    "bbox": [
+      [
+        147,
+        521,
+        844,
+        778
+      ]
+    ],
+    "page_idx": 16
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_9.jpg",
+    "caption": "Figure S21. (a) Mass spectra of RhB in HPLC-MS chromatogram. (b-h) Mass spectra after the degraded RhB under ultrasonic in HPLC-MS chromatogram.",
+    "bbox": [
+      [
+        150,
+        80,
+        848,
+        666
+      ]
+    ],
+    "page_idx": 17
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_10.jpg",
+    "caption": "Figure S22. The optimized RhB molecules and corresponding coordinates (Pink: C atom; Red: O atom; Blue: N atom; White: H atom).",
+    "bbox": [
+      [
+        339,
+        88,
+        655,
+        258
+      ]
+    ],
+    "page_idx": 18
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_11.jpg",
+    "caption": "Figure S23. The distribution of (a) HOMO and (b) LUMO of RhB, isosurface value is \\(0.05 \\mathrm{e} \\AA^{-3}\\) . The distribution of (c) \\(f^{+}\\) , (d) \\(f^{-}\\) , (e) \\(f^{0}\\) and (f) DD of RhB, isosurface value is \\(0.003 \\mathrm{e} \\AA^{-3}\\) . (Pink: C atom; Red: O atom; Blue: N atom; White: H atom)",
+    "bbox": [
+      [
+        147,
+        321,
+        850,
+        585
+      ]
+    ],
+    "page_idx": 18
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_12.jpg",
+    "caption": "Figure S24. The degradation pathway for RhB in the BF1.5 system.",
+    "bbox": [
+      [
+        150,
+        523,
+        848,
+        789
+      ]
+    ],
+    "page_idx": 19
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_13.jpg",
+    "caption": "Figure S15. (a) Mott-Schottky plots of BIO samples.",
+    "bbox": [],
+    "page_idx": 22
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_3.jpg",
+    "caption": "Figure 3. (b) \\(\\mathrm{H}_2\\mathrm{O}_2\\) yield of BIO and BF1.5 in pure water/air and pure water/Ar in sealable reactor.",
+    "bbox": [
+      [
+        336,
+        381,
+        666,
+        564
+      ]
+    ],
+    "page_idx": 23
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_14.jpg",
+    "caption": "Figure S14. (a) RRDE voltammograms recorded in \\(\\mathrm{O_2}\\) -saturated \\(0.1\\mathrm{M}\\) phosphate buffer solution \\(\\mathrm{(pH = 7)}\\) at a scan rate of \\(10\\mathrm{mV}\\mathrm{s}^{-1}\\) and a rotation speed of \\(1600\\mathrm{rpm}\\) . The potential of the Pt ring electrode was fixed at \\(0.6\\mathrm{V}\\) versus \\(\\mathrm{Ag / AgCl}\\) to oxidize the generated \\(\\mathrm{H}_2\\mathrm{O}_2\\) . \\(\\mathrm{Idisk}\\) and \\(\\mathrm{I}_{\\mathrm{ring}}\\) represent",
+    "bbox": [
+      [
+        211,
+        645,
+        784,
+        820
+      ]
+    ],
+    "page_idx": 23
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_15.jpg",
+    "caption": "Figure S15. RRDE voltammograms obtained in \\(0.1\\mathrm{M}\\) phosphate buffer solution \\(\\mathrm{(pH = 7)}\\) with a scan rate of \\(10\\mathrm{mV}\\mathrm{s}^{-1}\\) and a rotation rate of \\(1000\\mathrm{rpm}\\) . (a) The potential of the Pt ring electrode is set at \\(-0.23\\mathrm{V}\\) versus \\(\\mathrm{Ag / AgCl}\\) to detect \\(\\mathrm{O}_2\\) . (b)The potential of Pt ring electrode was set to \\(0.6\\mathrm{V}\\) versus \\(\\mathrm{Ag / AgCl}\\) to oxidize the generated \\(\\mathrm{H}_2\\mathrm{O}_2\\) . The oxidation current observed during RRDE tests indicates the oxidation of \\(\\mathrm{H}_2\\mathrm{O}_2\\) occurs at the ring electrode.",
+    "bbox": [
+      [
+        210,
+        147,
+        784,
+        320
+      ]
+    ],
+    "page_idx": 24
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_16.jpg",
+    "caption": "Figure R1. The (a, d, g, j) phase, (b, e, h, k) amplitude images, and (c, f, i, l) corresponding phase hysteresis loop and amplitude-voltage curves) of the as-prepared samples.",
+    "bbox": [
+      [
+        147,
+        174,
+        850,
+        703
+      ]
+    ],
+    "page_idx": 25
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_17.jpg",
+    "caption": "Figure S33. Cyclic stability for RhB degradation by BF1.5.",
+    "bbox": [
+      [
+        345,
+        283,
+        680,
+        476
+      ]
+    ],
+    "page_idx": 29
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_18.jpg",
+    "caption": "Figure S34. (a) XRD and (b) SERS spectra of BF1.5 and RBF1.5 (the recycled sample of BF1.5).",
+    "bbox": [
+      [
+        188,
+        515,
+        845,
+        709
+      ]
+    ],
+    "page_idx": 31
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_3.jpg",
+    "caption": "Figure 3. (c) Impact of various capture reagents on \\(\\mathrm{H}_2\\mathrm{O}_2\\) evolution by BF1.5.",
+    "bbox": [
+      [
+        356,
+        92,
+        650,
+        262
+      ]
+    ],
+    "page_idx": 31
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_19.jpg",
+    "caption": "Figure S15. RRDE voltammograms obtained in \\(0.1\\mathrm{M}\\) phosphate buffer solution \\(\\mathrm{(pH = 7)}\\) with a scan rate of \\(10\\mathrm{mV}\\mathrm{s}^{-1}\\) and a rotation rate of \\(1000\\mathrm{rpm}\\) . (a) The potential of the Pt ring electrode is set at -0.23 V versus \\(\\mathrm{Ag / AgCl}\\) to detect \\(\\mathrm{O}_2\\) . (b)The potential of Pt ring electrode was set to \\(0.6\\mathrm{V}\\) versus \\(\\mathrm{Ag / AgCl}\\) to oxidize the generated \\(\\mathrm{H}_2\\mathrm{O}_2\\) . The oxidation current observed during RRDE tests indicates the oxidation of \\(\\mathrm{H}_2\\mathrm{O}_2\\) occurs at the ring electrode.",
+    "bbox": [
+      [
+        217,
+        303,
+        783,
+        475
+      ]
+    ],
+    "page_idx": 33
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_20.jpg",
+    "caption": "Figure S25. Fe 2p XPS high-resolution spectrum of (a) fresh BF1.5 and (b) used BF1.5. (c) Fe 2p XPS high-resolution spectrum of used BF1.5 in BF1.5-CAT system.",
+    "bbox": [
+      [
+        147,
+        81,
+        850,
+        234
+      ]
+    ],
+    "page_idx": 33
+  }
+]

251f7a034dc7df81500bbec5e757640f2237d7146ba029a12c72cf88d91b0a0a/peer_review/images_list.json

@@ -0,0 +1,331 @@
+[
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_0.jpg",
+    "caption": "Fig. R1 Comparison between waveguide bundle and multimode waveguide. a Structural schematic of waveguide bundle and multimode waveguide. b Crosstalk values under different waveguide length along the light propagation direction for waveguide bundles with different spacing (blue) and five-mode MUX (red). Here, the crosstalk in the waveguide bundle case is defined as the power coupled into adjacent waveguide. c Normalized shoreline density for waveguide bundles (blue) and five-TE-mode waveguide (red).",
+    "bbox": [
+      [
+        172,
+        200,
+        822,
+        599
+      ]
+    ],
+    "page_idx": 7
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_1.jpg",
+    "caption": "Fig. R2 Design principle and results of the five-mode waveguide bend. a Schematic of the structure and control points of the MWB. Green points are the key path points for controlling waveguide width, while the orange points determine the curve shape of the MWB centerline. b-f Simulated transmission spectra of the MWB when the input mode is set to \\(\\mathrm{TE_0}\\) to \\(\\mathrm{TE_4}\\) , respectively. The mode indices 1-5 denote \\(\\mathrm{TE_0 - TE_4}\\) , respectively.",
+    "bbox": [
+      [
+        153,
+        92,
+        816,
+        653
+      ]
+    ],
+    "page_idx": 9
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_2.jpg",
+    "caption": "Fig. R3 Light propagation process. a 3D schematic of the MWB. b-f The light field distributions of the \\(\\mathrm{TE_0}\\) , \\(\\mathrm{TE_1}\\) , \\(\\mathrm{TE_2}\\) , \\(\\mathrm{TE_3}\\) and \\(\\mathrm{TE_4}\\) modes inside the bent waveguide at \\(1550\\mathrm{nm}\\) . g The light field distribution of the MDM photonic circuit when the converted mode is \\(\\mathrm{TE_4}\\) .",
+    "bbox": [
+      [
+        149,
+        175,
+        848,
+        455
+      ]
+    ],
+    "page_idx": 10
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_3.jpg",
+    "caption": "Fig. R4 Evolution of device insertion loss and proportion of edge pixels. Insets are the permittivity distribution of the design region of the five-mode MUX after various iterations.",
+    "bbox": [
+      [
+        250,
+        92,
+        775,
+        373
+      ]
+    ],
+    "page_idx": 15
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_4.jpg",
+    "caption": "Fig. R5 Schematic of different pixel structures used in (a) our work, (b) Ref. [45] in the main text, and (c) Ref. [35] in the main text.",
+    "bbox": [
+      [
+        330,
+        555,
+        668,
+        778
+      ]
+    ],
+    "page_idx": 20
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_5.jpg",
+    "caption": "Fig. R6 Device structure and mode conversion process of the inverse-designed dual-polarization five-mode MUX. The pixel side length is \\(120 \\mathrm{nm}\\) .",
+    "bbox": [
+      [
+        156,
+        205,
+        841,
+        464
+      ]
+    ],
+    "page_idx": 22
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_6.jpg",
+    "caption": "Fig. R7 Device performance of the dual-polarization five-mode MUX. a-e Simulated transmission spectra when the \\(\\mathrm{TM}_0 / \\mathrm{TE}_0\\) mode is incident from CH1 to CH5 at the wavelength range of \\(1530\\) to \\(1570 \\mathrm{nm}\\) . Insets include the light propagation processes and converted mode profiles at the output multimode waveguide for each mode channel.",
+    "bbox": [
+      [
+        175,
+        92,
+        825,
+        650
+      ]
+    ],
+    "page_idx": 23
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_7.jpg",
+    "caption": "Fig. R8 Schematic representation of two types of fabrication errors. a Variations in etching pixel size, where the gray dashed box indicates the ideal pixel size. b The waveguide side-wall angle variations. The gray dashed box represents the cross-section of the ideal waveguide with vertical side-walls.",
+    "bbox": [
+      [
+        147,
+        628,
+        850,
+        722
+      ]
+    ],
+    "page_idx": 25
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_8.jpg",
+    "caption": "Fig. R9 The simulated transmission spectra of the five-mode MUX under \\(10^{\\circ}\\) side-wall angle variations. (a) Simulated insertion losses and (b)-(e) simulated mode-convert crosstalks for CH1 input. (g) Simulated insertion losses and (f), (h)-(j) simulated mode-convert crosstalks for CH2 input. (m) Simulated insertion losses and (k)-(l), (n)-(o) simulated mode-convert crosstalks for CH3 input. (s) Simulated insertion losses and (p)-(r), (t) simulated mode-convert crosstalks for CH4 input. (y) Simulated insertion losses and (u)-(x) simulated mode-convert crosstalks for CH5 input.",
+    "bbox": [
+      [
+        152,
+        88,
+        848,
+        597
+      ]
+    ],
+    "page_idx": 27
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_9.jpg",
+    "caption": "Fig. R10 Pictures of the fabricated circuits. a The four-mode MDM circuit. b The five-mode MDM circuit.",
+    "bbox": [
+      [
+        355,
+        171,
+        640,
+        443
+      ]
+    ],
+    "page_idx": 30
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_10.jpg",
+    "caption": "Fig. R11 Simulation set-up for evaluating the impact of waveguide length.",
+    "bbox": [
+      [
+        155,
+        487,
+        835,
+        570
+      ]
+    ],
+    "page_idx": 30
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_11.jpg",
+    "caption": "Fig. R12 Simulation results of the waveguide length evaluation. (a)-(b) Comparison of transmission spectra across four monitors for the CH-1 input. (c)-(d) Comparison of transmission spectra across four monitors for the CH-2 input. (e)-(f) Comparison of transmission spectra across four monitors for the CH-3 input. (g)-(h) Comparison of transmission spectra across four monitors for the CH-4 input. (i)-(j) Comparison of transmission spectra across four monitors for the CH-5 input. (k) Light propagation process across the entire simulation region for CH-1 to CH-5 inputs.",
+    "bbox": [
+      [
+        159,
+        175,
+        833,
+        491
+      ]
+    ],
+    "page_idx": 31
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_12.jpg",
+    "caption": "Fig. R13 Simulated distribution of the normalized E-field magnitude in logarithmic scale for CH-1 input.",
+    "bbox": [
+      [
+        223,
+        666,
+        775,
+        833
+      ]
+    ],
+    "page_idx": 31
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_3.jpg",
+    "caption": "Fig. 3 Measured optical performance of the fabricated four-mode and five-mode MUXs designed with the EG-ADO method. a-b Microscope images of the back-to-back (a) four-mode and (b) five-mode MDM circuits. c Measured transmission spectra of the four-mode circuit. The inset depicts the false-color scanning electron microscopy (SEM) image of the four-mode MUX. d-h Measured transmission spectra of the five-mode circuit when the light is incident from I₁ to I₅. The shaded areas represent the C band range (1530-1565 nm).",
+    "bbox": [
+      [
+        149,
+        240,
+        850,
+        686
+      ]
+    ],
+    "page_idx": 32
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_13.jpg",
+    "caption": "Fig. R14 Time consumption comparison for optimization of five-mode and six-mode MUXs using different processors and inverse design algorithms.",
+    "bbox": [
+      [
+        268,
+        620,
+        728,
+        870
+      ]
+    ],
+    "page_idx": 37
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_3.jpg",
+    "caption": "Fig. 3 Measured optical performance of the fabricated four-mode and five-mode MUXs designed with the EG-ADO method. a-b Microscope images of the back-to-back (a) four-mode and (b) five-mode MDM circuits. c Measured transmission spectra of the four-mode circuit. The inset depicts the false-color scanning electron microscopy (SEM) image of the four-mode MUX. d-h Measured transmission spectra of the five-mode circuit when the light is incident from I₁ to I₅. The shaded areas represent the C band range (1530-1565 nm).",
+    "bbox": [],
+    "page_idx": 39
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_1.jpg",
+    "caption": "Fig. 1 On-chip multi-dimensional interconnect architecture. a Artistic representation for an on-chip link between two XPUs utilizing inverse-designed digital metamaterials within future optical compute interconnect systems. Here, the term “XPU” serves as a device abstraction including various computational architectures, including CPUs, GPUs, FPGAs, and other accelerators. These broadband, inverse-designed digital metamaterials facilitate the multiplexing of a substantial number of data channels across both wavelength and mode dimensions. Additionally, the system incorporates E/O module for converting electrical signals to optical signals, and O/E module for the reverse conversion. Signal processing can be supported by co-packaged CMOS electronics. b Strategies on enhancing interconnect capacity across three dimensions: symbol, wavelength, and mode. This study showcases the integration of MDM and DWDM, enabling nearly a hundred wavelength channels per orthogonal mode. Each channel efficiently supports high-order pulse amplitude modulation (PAM) signals, significantly expanding the data capacity per waveguide. c Foundry-compatible inverse-designed digital metamaterials. Our design features a minimum feature size of 120 nm, suitable for robust and large-scale production by commercial foundries. Compared to conventionally designed high-order mode MUX, the inverse-designed MUX significantly reduces the footprint by an order of magnitude.",
+    "bbox": [
+      [
+        160,
+        84,
+        833,
+        451
+      ]
+    ],
+    "page_idx": 42
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_2.jpg",
+    "caption": "Fig. 2 The EG-ADO method and the DM-based five-mode MUX. a The workflow of the EG-ADO method. During each iteration in the first stage, the forward electric fields \\((e_{for})\\) and adjoint fields \\((e_{adj})\\) for all modes are",
+    "bbox": [
+      [
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+    "img_path": "images/Figure_unknown_14.jpg",
+    "caption": "Fig. R15 Simulation results of reflection and scattering analysis. a Schematic of the reflection and scattering direction. b-f Transmission spectra of the reflected and scattered light when the source is input from CH1-CH5, respectively.",
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+    "page_idx": 49
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_15.jpg",
+    "caption": "Fig. R16 Simulated distribution of the normalized E-field magnitude in logarithmic scale for CH-1 input. White contour lines indicating magnitude levels of 0.1, 0.01, and 0.001 are added. The boundary of the five-mode MUX is marked with black solid lines.",
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+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_16.jpg",
+    "caption": "Fig. R17 Microscope image of the fabricated six-mode MDM circuit. This picture includes the bare fibers currently used for fiber-chip coupling.",
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+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_17.jpg",
+    "caption": "Fig. R18 (a)-(f) Measured transmission spectra of the six-mode circuit when the light is incident from \\(\\mathbf{I}_1\\) to \\(\\mathbf{I}_6\\)",
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+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_18.jpg",
+    "caption": "Fig. R19 Experimental setup of the single-wavelength transmission experiment.",
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+    "page_idx": 58
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+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_19.jpg",
+    "caption": "Fig. R20 Comparison of various inverse-designed mode MUXs under two different definitions of MDF:Area/N and Area/N2. The reference numbers in the figure correspond to those cited in the main manuscript.",
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+    "caption": "Figure R1. (a) J-V characteristics of OSCs based on BTP-eC9, L8-BO-F and BTP-eC9:L8-BO-F films. (b) TRPL spectra of BTP-eC9 and BTP-eC9:L8-BO-F films.",
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+    "caption": "Figure R2. Schematic representations of the doctor-blade method, the device structure and the \\(J - V\\) characteristics of the corresponding OSCs.",
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+    "caption": "Figure R3. Photostability of 120 nm- and 300 nm-thick ternary devices measured under continuous 1 sun illumination in air.",
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+    "caption": "Figure R4. Normalized reduced absorption and PL spectra of (a) PM6:BTP-eC9, (b) PM6:BTP-eC9:L8-BO-F, and (c) LBL-processed PM6:BTP-eC9:L8-BO-F films.",
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+    "caption": "Figure R5. \\(\\mathsf{EQE}_{\\mathsf{EL}}\\) spectra of OSCs at various injection current density.",
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+    "caption": "Figure R6. Optical transitions depicted in an energy diagram with displaced potential wells for the ground state (GS) and excited state (ES), taking into account that the reaction coordinate remains invariant during the transition. Vertical blue arrows represent absorption and vertical red arrows represent emission (Sustainable Energy Fuels 2018, 2, 538-544).",
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+    "caption": "Figure R7. (a) UV-vis absorption spectra of 120 nm-thick PM6:BTP-eC9 and PM6:BTP-eC9:L8-BO-F films, and (b) EQE spectra of the corresponding devices.",
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+    "caption": "Figure R8. J-V curves of LBL-processed ternary OSC with \\(1cm^2\\) active area, and the corresponding EQE spectrum. The inset is a photograph of the real large-area device.",
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+    "caption": "Figure R9. Photostability of 300 nm-thick ternary devices measured under continuous 1 sun illumination in air.",
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+    "caption": "Figure: Using network approaches to understand interactions in host–parasite networks, from Runghen, et al. \\(^{5}\\) .",
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+    "caption": "Figure 7. Validation of the subtypes by both experimental and computational methods a. Scatter plot of the differential expressions of BRAF-relevant genes in CS2 and CS3 subtypes. The x and y axes respectively represent the significant Log2FC calculated for comparing CS2 or CS3 to the other clusters, and only genes showed significant differential expression between PTC tumor",
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+    "caption": "Fig S6. Low correlations between mRNAs and proteins.",
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+    "page_idx": 8
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+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_1.jpg",
+    "caption": "Fig S4. Multi-omics alterations related with gene mutations in BRAF, MUC16 and TERT promoter.",
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+    "type": "image",
+    "img_path": "images/Figure_unknown_2.jpg",
+    "caption": "Fig S6. Low correlations between mRNAs and proteins.",
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+    "page_idx": 13
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+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_3.jpg",
+    "caption": "Fig S10. g-h. Scatter plot showing the mean decrease Gini of the genes (a) and metabolites (b). The MeanDecreaseGini was estimated based on the random forest algorithm.",
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+    "img_path": "images/Figure_7.jpg",
+    "caption": "Figure 7. Validation of the subtypes by both experimental and computational methods a. Scatter plot of the differential expressions of BRAF-relevant genes in CS2 and CS3 subtypes. The",
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+    "page_idx": 22
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2b04dd76a5fa335cb455dcacc22204a6b075a9a840a42918f9d5f80f6b54edc7/peer_review/images_list.json

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+    "caption": "5. Some children in the study had repeated scans and the authors include all scans that passed quality control to \"boost statistical power\". While such an approach could increase power it also creates a lack of independence amongst observations within the analyses. Do the results hold if only one observation from each participant is included?",
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+    "caption": "Figure 1: Photomicrographs of one recorded neuron recorded in lamina I SDH (A) Photomicrographs showing a interneuron recorded using the whole-cell patch-clamp recording technique (DIC image, right). Interneuron was filled with fluorourby through the patch pipette (fluorescence image, left). (B) Immunofluorescence images showing the PKCy immunostaining (left) and neurobiotin (Nb) labelling of the recorded neuron (right).",
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32507eeb60877ab841f55cd74a4edd282eaa038739de637f2c086eca7628daa1/peer_review/images_list.json

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+    "img_path": "images/Supplementary_Figure_37.jpg",
+    "caption": "Fig. R1. Cl 2p XPS spectra of PTh/BVO before and after i-t testing in KBi and seawater. (This Figure is included as Supplementary Fig. 37 in the revised manuscript)",
+    "bbox": [],
+    "page_idx": 0
+  },
+  {
+    "type": "image",
+    "img_path": "images/Supplementary_Figure_42.jpg",
+    "caption": "Fig. R2. Long-term PEC stability of PPy/BVO and PANI/BVO at 1.23 V vs. RHE in seawater electrolyte \\(\\mathrm{(pH = 8.1)}\\) under AM 1.5G illumination. (This Figure is included as Supplementary Fig. 42 in the revised manuscript)",
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+    "page_idx": 6
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_4a.jpg",
+    "caption": "Fig. R3. Long-term PEC stability of PTh/BVO and BVO at 1.23 V vs. RHE in seawater electrolyte (pH = 8.1) under AM 1.5G illumination. (This Figure is included as Fig. 4a in the revised manuscript)",
+    "bbox": [
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+    "page_idx": 7
+  },
+  {
+    "type": "image",
+    "img_path": "images/Supplementary_Figure_43.jpg",
+    "caption": "Fig. R4. LSV curves of PTh/TiO2 and TiO2 photoanode in KBi (pH = 9) under (a) AM1.5G and (b) dark. SEM images of (c) TiO2 and (d) PTh/TiO2. (e) Corresponding EDS element mapping images. (This Figure is included as Supplementary Fig. 43 in the revised manuscript)",
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+  },
+  {
+    "type": "image",
+    "img_path": "images/Supplementary_Figure_44.jpg",
+    "caption": "Fig. R5. LSV curves of PTh/WO₃ and WO₃ photoanode in KBi (pH = 9) under (a) AM1.5G and (b) dark. SEM images of (c) WO₃ and (d) PTh/WO₃. (e) Corresponding EDS element mapping images. (This Figure is included as Supplementary Fig. 44 in the revised manuscript)",
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+    "caption": "Fig. R6. Atomic structures of \\(\\mathrm{Cl}^{-}\\) and \\(\\mathrm{OH}^{-}\\) adsorption on [FeCl4] unit. (This Figure is included as Fig. 4b in the revised manuscript)",
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+    "page_idx": 10
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+    "img_path": "images/Figure_4c.jpg",
+    "caption": "Fig. R7. Schematics and free energy diagram for OER pathway on \\(\\mathrm{PTh / BVO}\\) . (This Figure is included as Fig. 4c in the revised manuscript)",
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+    "page_idx": 11
+  },
+  {
+    "type": "image",
+    "img_path": "images/Supplementary_Figure_5.jpg",
+    "caption": "Fig. R8. Fe 2p XPS spectra of (a) PTh and PTh/BVO and (b) PTh/BVO before and after stability testing in seawater. (This Figure is included as Supplementary Fig. 5 and Fig. 35 in the revised manuscript)",
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+    "page_idx": 11
+  },
+  {
+    "type": "image",
+    "img_path": "images/Supplementary_Figure_28.jpg",
+    "caption": "Fig. R9. Charge transfer efficiency of PTh/BVO and BVO in PEC seawater splitting. (This Figure is included as Supplementary Fig. 28 in the revised manuscript)",
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+    "page_idx": 12
+  },
+  {
+    "type": "image",
+    "img_path": "images/Supplementary_Figure_38.jpg",
+    "caption": "Fig. R10. (a) Digital photographs of PTh/BVO photoanodes with different areas. (b) PEC performance of PTh/BVO and BVO with \\(30~\\mathrm{cm}^2\\) . (c) Stability testing of PTh/BVO at \\(1.23~\\mathrm{V}\\) vs. RHE in seawater electrolyte \\((\\mathrm{pH} = 8.1)\\) under AM 1.5G illumination. (This Figure is included as Supplementary Fig. 38 in the revised manuscript)",
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+    "img_path": "images/Supplementary_Figure_32.jpg",
+    "caption": "Fig. R11. (a) TEM images of PTh/BVO after stability test. (b) FTIR spectra of PTh/BVO before and after stability testing. (This Figure is included as Supplementary Fig. 32 and Fig. 33 in the revised manuscript)",
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+    "page_idx": 13
+  },
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+    "type": "image",
+    "img_path": "images/Supplementary_Figure_29.jpg",
+    "caption": "Fig. R12. Time course of \\(\\mathrm{O_2}\\) and \\(\\mathrm{H_2}\\) gas evolution of PEC seawater splitting using PTh/BVO photoanode. (This Figure is included as Supplementary Fig. 29 in the revised manuscript)",
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+    "type": "image",
+    "img_path": "images/Figure_unknown_0.jpg",
+    "caption": "Figure R1 North Atlantic response to Indian Ocean warming. a Temporal evolution in annual-mean SST anomalies in \\(^{\\mathrm{*}}\\mathrm{PI\\_IO + 1C^{\\prime \\prime}}\\) , compared to \\(^{\\mathrm{*}}\\mathrm{PI\\_IO + 0C^{\\prime \\prime}}\\) model experiments. b Same as a but for longwave radiative flux. c Same as a but for net surface heat fluxes. For fluxes, the downward direction is positive (surface warming). The blue (or red) line shows annual mean data and the black line represents an 11-year running mean of the red line (or blue line). d Same as a but for Atlantic meridional overturning circulation (AMOC) strength. The AMOC strength is estimated as the maximum stream function within 500-5500 m, \\(30^{\\circ}\\mathrm{N}\\) to \\(70^{\\circ}\\mathrm{N}\\) . The red line shows annual mean data, and the black line shows an 11- year running mean of the red line. e Horizontal pattern of sea surface salinity (PSU) anomalies in \\(^{\\mathrm{*}}\\mathrm{PI\\_IO + 1C^{\\prime \\prime}}\\) , compared to \\(^{\\mathrm{*}}\\mathrm{PI\\_IO + 0C^{\\prime \\prime}}\\) model experiments.",
+    "bbox": [],
+    "page_idx": 0
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_1.jpg",
+    "caption": "Figure R2 North Atlantic response to Indian ocean warming. a Horizontal patterns of SST and surface wind anomalies between PI_IO+1C and PI_IO + 0C model experiments during the initial phase (0-30yrs). b Same as a but for the final phase (70-100yrs). c temporal evolution of SST anomalies averaged over \\(0^{\\circ} - 80^{\\circ}W\\) , \\(50^{\\circ} - 70^{\\circ}N\\) between PI_IO+1C and PI_IO + 0C model experiments. d Same as c but for net surface fluxes (W m-2). \"Initial\" refers to an average for Years 1-30, while \"final\" refers to Years 70-100. The blue (or red) line shows annual mean data and the black line represents an 11-year running mean of the red line (or blue line)",
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+    "page_idx": 7
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_2.jpg",
+    "caption": "Figure R3 Indian ocean response to north Atlantic ocean warming. a Horizontal patterns of SST anomalies ( \\(^\\circ \\mathrm{C}\\) ) between \\(\\mathrm{PI\\_NA + 1C}\\) and \\(\\mathrm{PI\\_NA + 0C}\\) model experiments during total periods (0-100yrs). b Same as a but for latent heat fluxes (W m-2) and surface winds (m s-1). c same as but for vertical advection by upwelling between 50-100m or of ocean model (X10 g m-2 s-1). 100year simulated data are used for analysis.",
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+    "page_idx": 9
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+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_3.jpg",
+    "caption": "Figure R4 Relationship between relative IO and NA a. Observed lead-lag correlation coefficient between the IO and NA indices during 1950-2020. The lag is positive (negative) when the IO leads (lags). The black line represents SST data that are removed long-term linear trends and the red line shows original SST data. b. same as a but for relative IO and NA. The relative IO and NA are defined as average SST in the Indian Ocean (30°S–30°N, 40°E–120°E) minus the whole tropical ocean (30°S–30°N, 0°-360°E).",
+    "bbox": [
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+    "page_idx": 10
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_4.jpg",
+    "caption": "Figure R5. Historical warming trends. Observed time series of the NA (red line) and IO (blue line) indices. Long-term linear trends in the SST data were removed before analysis and the last 5 years were excluded from the analysis.",
+    "bbox": [
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+    "page_idx": 11
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_5.jpg",
+    "caption": "Figure R6 Observed lead-lag correlation coefficient between the IO and NA indices during 1900-2020. The lag is positive (negative) when the IO leads (lags). The black line represents SST data that are",
+    "bbox": [
+      [
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+    ],
+    "page_idx": 12
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_6.jpg",
+    "caption": "Figure R8. a Observed SST (K) and surface wind anomalies (arrow, m s-1) regressed onto the NA index \\((0^{\\circ} - 70^{\\circ}N, 80^{\\circ} - 0^{\\circ}W)\\) . The hatched area represents the regressed SSTA and is significant at the \\(95\\%\\) confidence level. b Same as a but from model simulated SST. c Same as a but for the IO index \\((30S^{\\circ} - 30^{\\circ}N, 40^{\\circ} - 120^{\\circ}E)\\) , d same as b but the IO index \\((30S^{\\circ} - 30^{\\circ}N, 40^{\\circ} - 120^{\\circ}E)\\) . The model simulation is conducted by free historical forcings. The 11-year running average data were used for 1950–2020.",
+    "bbox": [],
+    "page_idx": 12
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_7.jpg",
+    "caption": "Figure R9. a Time series of annual mean observed IO SST. Black line shows observed SST anomalies and color lines represent IO SST with different trends. The trend of the black line is 0.0145C year-1 and the trends of each color line are monotonically reduced (interval is 0.05) and the trend of the bottom line is 0.01. b Same as a but for NA SST.",
+    "bbox": [
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+    "page_idx": 13
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_8.jpg",
+    "caption": "Figure R1 a Observed SST (K) and surface wind anomalies (arrow, m s-1) regressed onto the IO index \\((0^{\\circ} - 70^{\\circ}\\mathrm{N},80^{\\circ} - 0^{\\circ}\\mathrm{W})\\) . The 11-year running average data were used for 1950-2020. The hatched area represents the regressed SSTA and is significant at the \\(95\\%\\) confidence level. b Anomalies in SST ( \\(^\\circ \\mathrm{C}\\) and surface wind from the fixed preindustrial (PI) simulation with observed IO SST anomalies. c Temporal evolution in annual-mean SST anomalies. d Same as b but for net surface heat flux (positive values represent downward direction, W m-2). e Same as b but for Atlantic meridional overturning circulation (AMOC) strength. The AMOC strength is estimated as the maximum stream function within 500-5500 m, \\(30^{\\circ}\\mathrm{N}\\) to \\(70^{\\circ}\\mathrm{N}\\) . The blue (or red) line shows annual mean data and the black line represents an 11-year running mean of the red line (or blue line). f Same as b but for sea surface salinity. The anomalies are computed for the 100 years of the PI_NA+1C experiment with respect to the pre-industrial simulation (PI_NA+0C).",
+    "bbox": [
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+      ]
+    ],
+    "page_idx": 13
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_9.jpg",
+    "caption": "Figure R2. a Observed SST (K) and surface wind anomalies (arrow, m s-1) regressed onto the NA index \\((0^{\\circ} - 70^{\\circ}\\mathrm{N}\\) , \\(80^{\\circ} - 0^{\\circ}\\mathrm{W}\\) ). The 11-year running average data were used for 1950–2020. The hatched area represents the regressed SSTA and is significant at the 95% confidence level. b Anomalies in SST (°C) and surface wind (m s-1) response to the NA-SST warming forcing reflecting observed IO-SST warming pattern under PI simulations. c Same as b but for latent heat flux and surface wind. Positive color means downward. d. Same as b but for upward ocean water fluxes. Positive colors mean upward. The anomalies are computed for the 100 years of the PI_NA+1C experiment with respect to the pre-industrial simulation (PI_NA+0C).",
+    "bbox": [
+      [
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+      ]
+    ],
+    "page_idx": 15
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_10.jpg",
+    "caption": "Figure R1: Historical warming trends. a Observed trends (1950–2020) in annual-mean sea surface temperature (SST; units: \\(^\\circ \\mathrm{C} 50 \\mathrm{year}^{-1}\\) ). The red (blue) box represents the region where the Indian (North Atlantic) Ocean index was defined. b-c Observed SST (K) and surface wind anomalies (arrow, \\(\\mathrm{m s}^{-1}\\) ) regressed onto (b) the North Atlantic Ocean (NA) index ( \\(0^\\circ - 70^\\circ \\mathrm{N}\\) , \\(80^\\circ - 0^\\circ \\mathrm{W}\\) ) and (c) Indian Ocean (IO) index ( \\(30^\\circ \\mathrm{S} - 30^\\circ \\mathrm{N}\\) , \\(40^\\circ - 120^\\circ \\mathrm{E}\\) ). The hatched area represents the regressed SST and is significant at the \\(95\\%\\) confidence level. d Observed time series of the NA (red line) and IO (blue line) indices. (e) The observed lead-lag correlation coefficient between the IO and NA indices. The lag is positive (negative) when the IO leads (lags) and the grey lines represent a \\(95\\%\\) significance level. For b-d, the 11-year running average data were used for 1950–2020 and long-term linear trends were removed. For e, the last 5 years were excluded from the analysis, and the long-term linear trends in the SST data were",
+    "bbox": [
+      [
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+      ]
+    ],
+    "page_idx": 16
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_11.jpg",
+    "caption": "Figure R1 Upper-level circulation induced by IO-NA warming. a Observed upper-level velocity potential (shading, \\(10^{5} \\mathrm{m}2 \\mathrm{s} - 1\\) ) and divergent winds (m s-1) anomalies regressed onto the NA index \\((0^{\\circ} - 70^{\\circ} \\mathrm{N}, 80^{\\circ} \\mathrm{W} - 0^{\\circ})\\) . The 11-year running average was used for 1950–2019, and the first and last 5 years were excluded. The dotted area represents significant velocity potential at the \\(95\\%\\) confidence level. b Same as a but associated with the IO index \\((35^{\\circ} - 30^{\\circ} \\mathrm{N}, 40^{\\circ} - 120^{\\circ} \\mathrm{E})\\) . c Same as but from the model with observed NA index. d Same as but b from the model with IO index. Long-term linear trends in the SST data were removed before regression.",
+    "bbox": [
+      [
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+      ]
+    ],
+    "page_idx": 20
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_12.jpg",
+    "caption": "Figure R2 Relationship between IO-NA warming chain and Pacific indices. a. Observed lead-lag correlation coefficient between the NA and PDO, IPO, and decadal ENSO indices. The lag is positive (negative) when the NA leads (lags). PDO is defined as the leading principal component of North Pacific monthly sea surface temperature variability. The IPO is defined as the second EOF (after the global warming mode) of decadally low-pass filtered SST (Yang et al. 2020). The decadal ENSO is defined as the Nino3.4 index of decadally (11year) low-pass filtered SST. The grey lines represent a 95% significance level and the green line shows zero. b Same as a but for IO index. The 11-year running",
+    "bbox": [
+      [
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+        866,
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+      ]
+    ],
+    "page_idx": 21
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_13.jpg",
+    "caption": "Figure R3 Indian Ocean response by NA warming from pre-industrial simulations. (a) Horizontal patterns of SST anomalies ( \\(^\\circ \\mathrm{C}\\) ), (b) latent heat fluxes ( \\(\\mathrm{Wm}^{-2}\\) ) and surface winds ( \\(\\mathrm{m}\\) \\(\\mathrm{s}^{-1}\\) ), and (c) combined anomalies of sensible heat flux, solar and longwave radiation between \\(\\mathrm{PI\\_NA + 0C}\\) and \\(\\mathrm{PI\\_NA + 1C}\\) model experiments. 100-year simulated data are used for analysis.",
+    "bbox": [
+      [
+        125,
+        400,
+        891,
+        531
+      ]
+    ],
+    "page_idx": 26
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_14.jpg",
+    "caption": "Figure R4 Change atmospheric circulation. a Walker circulation changes (arrows) and troposphere vertical velocity anomalies (color shading) averaged between \\(5^{\\circ}\\) S and \\(5^{\\circ}\\) N over between PI_NA+1C and PI_NA+0C. The vertical velocity is magnified by a factor of 750 to make its scale comparable to that of zonal wind. b Same as a but between PI_IO+1C and PI_IO+0C.",
+    "bbox": [
+      [
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+      ]
+    ],
+    "page_idx": 31
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_15.jpg",
+    "caption": "Figure R5. IO-NA interaction from pre-industrial simulations. a-e NA response by IO warming. a Temporal evolution in annual-mean SST anomalies ( \\(^\\circ \\mathrm{C}\\) ) over NA region. b Same as a but for longwave radiation. The downward direction is positive (warming). c Same as a but for net surface fluxes. The blue (or red) line shows annual mean data and the black line represents an 11-year running mean of the red line (or blue line). d Temporal evolution of anomalies in Atlantic meridional overturning circulation (AMOC) strength. The AMOC strength is estimated as the maximum stream function within 500–5500 m, \\(30^\\circ \\mathrm{N}\\) to \\(70^\\circ \\mathrm{N}\\) . The red (or blue) line shows annual mean data, and the black line shows an 11-year running mean of the red (or blue) line.",
+    "bbox": [
+      [
+        152,
+        416,
+        795,
+        675
+      ]
+    ],
+    "page_idx": 32
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_16.jpg",
+    "caption": "Figure R6 North Atlantic Ocean response by IO warming from pre-industrial simulations. (a) Horizontal patterns of cloudiness (\\%) and (b) longwave heat fluxes (W m⁻²) between PI_IO+0C and PI_IO + 1C model experiments. 100-year simulated data are used for analysis.",
+    "bbox": [
+      [
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+        105,
+        750,
+        290
+      ]
+    ],
+    "page_idx": 34
+  }
+]

3281df76d22a18711eb67e60f09d3f0de788301819785ef7a4fa670b0c97c44e/peer_review/images_list.json

@@ -0,0 +1,233 @@
+[
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_0.jpg",
+    "caption": "Figure R1.1. Removal of blood contamination. Representative photograph of (A) lung and (B) gill sample before and after additional washing steps to remove blood.",
+    "bbox": [],
+    "page_idx": 0
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_1.jpg",
+    "caption": "Figure R1.2. Effect on removal of blood on cell type assignment. Uniform Manifold Approximation and Projection (UMAP) of before (left) and after (right) additional washing steps to remove blood in the gill (A) and lung (B). Cells are color-coded by cluster cell type.",
+    "bbox": [
+      [
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+        88,
+        710,
+        465
+      ]
+    ],
+    "page_idx": 9
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_2.jpg",
+    "caption": "Figure R1-3 Sequencing of additional lungfish samples detects more cells and largely preserves the cell type assignments. Uniform Manifold Approximation and Projection of (A) gill and (B) lung cell types our initial submission (left panel) and a dataset including additional scRNA-seq samples. Cells are color-coded by cluster cell type.",
+    "bbox": [
+      [
+        176,
+        85,
+        815,
+        247
+      ]
+    ],
+    "page_idx": 10
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_3.jpg",
+    "caption": "Figure R1.5. The H&E stain of African lungfish lungs and gill filament. (A) The overall H&E staining image of lungfish lungs. (B) The Detail View Profile of the red box (I) in (A). The \\(\\bullet\\) represents alveolar epithelial cells; \\(\\bullet\\) macrophage cells. (C) The Detail View Profile of the red box (II) in (A). Red circle represents the lymphoid nodes. (D) The overall H&E staining image of lungfish gills. (E) The Detail View Profile of the red box(I) in (D). The \\(\\bullet\\) denotes macrophage cells, a red circle lymphoid node.",
+    "bbox": [],
+    "page_idx": 11
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_4.jpg",
+    "caption": "Figure R1.6. The expression patterns in of lungfish granulocytes markers. (A) Bubble plot of typical granulocytes markers shows the expression pattern across cell types of lungfish gills. Circle size reflects the percentage of cells within a cell type which express the specific genes. The shades of color show average expression levels of specific gene. (B) Bubble plot of typical granulocytes markers shows the expression pattern across cell types of lungfish lungs. Annotated as in Fig.R1.6.",
+    "bbox": [
+      [
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+        84,
+        820,
+        269
+      ]
+    ],
+    "page_idx": 12
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_5.jpg",
+    "caption": "Figure R1.7. The cell features of Immune cell_F13A1_SLC37A in African lungfish gills data.",
+    "bbox": [
+      [
+        195,
+        177,
+        789,
+        521
+      ]
+    ],
+    "page_idx": 14
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_6.jpg",
+    "caption": "Figure R1.8. The cell features of NK cell in African lungfish gills data. (A) Bubble plot of typical markers of NK cell like, T cell and CD8+T cell shows the expression pattern across cell types of lungfish gills. Annotated as in Fig.R1.4A. (B) Bubble plot of top GSEA terms of DEGs of NK cell like in the gill. GSEA denotes Gene Set Enrichment Analysis; DEG, differentially expressed gene. The color gradient in the legend represents the normalized enrichment score, circle size and the color reflect the -log10(pvalue).",
+    "bbox": [
+      [
+        176,
+        312,
+        815,
+        500
+      ]
+    ],
+    "page_idx": 16
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_7.jpg",
+    "caption": "Figure R3.2. The cell type ratio of lungfish tissues using spatial transcriptomic test. The expression of marker genes from STOmics experiment.",
+    "bbox": [],
+    "page_idx": 17
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_8.jpg",
+    "caption": "Figure R3.3. Validation of selected marker genes. (A) Fluorescence microscopy image of lungfish lung (left) and gill (right). Green, digoxigenin-labeled marker genes probes amplified using FITC-TSA; blue, DAPI. Yellow boxes indicate regions shown to the right of each tissue. (B) A schematic diagram of lungfish lung alveolar structure shows the major elements: alveolar cells, macrophages, epithelial cells, basal lamina, and a blood vessel. (C) Fluorescence microscopy image of lungfish lung. Green, digoxigenin-labeled marker genes probes of arpclb (green) and npc2 (red). Yellow boxes indicate regions shown to the right.",
+    "bbox": [
+      [
+        185,
+        100,
+        808,
+        690
+      ]
+    ],
+    "page_idx": 18
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_9.jpg",
+    "caption": "Figure R3.4. The cell atlas of zebrafish tissues from ZCL dataset. (A) FFT-accelerated",
+    "bbox": [
+      [
+        176,
+        91,
+        818,
+        240
+      ]
+    ],
+    "page_idx": 19
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_10.jpg",
+    "caption": "Figure R3.5. Cell type and features assignment across species. (A) Violin plots of orthologous genes with conserved expression in different cell types across species.",
+    "bbox": [
+      [
+        176,
+        422,
+        820,
+        770
+      ]
+    ],
+    "page_idx": 29
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_11.jpg",
+    "caption": "Figure R3.6. Evaluation of different cross-species methods on the lungfish dataset. Each row represents the comparison of homologous organs from two species. Each column represents the result from a separate tool. KLD: Cell-cell similarities between lungfish and the other species. The top 5% highest Kullback–Leibler divergence (KDL) values are indicated as arches connecting cell types. Seurat: UMAP plots from integrated dataset of lungfish and other species. The cell types are labeled on the plot; the prefix of cell types is the name of the species. SAMap: Sankey plot of the cell-type mappings. Edges with alignment score <0.2 are omitted. CAME: The predicted cell-type probabilities for each cell (each column) in the lungfish lung (gill) scRNA-seq data. The gene expressions of the other species were taken as the reference. Each row indicates a cell type in the reference dataset.",
+    "bbox": [
+      [
+        178,
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+        441
+      ]
+    ],
+    "page_idx": 31
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_12.jpg",
+    "caption": "Figure R1.1. Effect on removal of blood on cell type assignment. Uniform Manifold Approximation and Projection (UMAP) of before (left) and after (right) additional washing steps to remove blood in the gill (A) and lung (B). Cells are color-coded by cluster cell type.",
+    "bbox": [
+      [
+        180,
+        308,
+        790,
+        787
+      ]
+    ],
+    "page_idx": 33
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_13.jpg",
+    "caption": "Figure R1.2. Sequencing of additional lungfish samples detects more cells and largely preserves the cell type assignments. Uniform Manifold Approximation and Projection of (A) gill and (B) lung cell types our initial submission (left panel) and a dataset including additional scRNA-seq samples. Cells are color-coded by cluster cell type.",
+    "bbox": [
+      [
+        176,
+        610,
+        820,
+        774
+      ]
+    ],
+    "page_idx": 34
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_14.jpg",
+    "caption": "Figure R1.3. The H&E stain of African lungfish lungs and gill filament from freshwater sample.",
+    "bbox": [
+      [
+        171,
+        90,
+        825,
+        848
+      ]
+    ],
+    "page_idx": 38
+  },
+  {
+    "type": "image",
+    "img_path": "images/Extended_Data_Figure_1f.jpg",
+    "caption": "Figure R1.4. The fluorescence microscopy image of lungfish lung and gills. (A) Fluorescence microscopy image of lungfish lung. Green, digoxigenin-labeled marker genes probes amplified using FITC-TSA; blue, DAPI. FmW, fibromuscular wall; AS, air sacs. (B) Fluorescence microscopy image of lungfish gill. Cr, cartilage. (C, D, E) The revised figures of Fig.1f (C), g(D) and Extended Data Fig. 1f (E).1, fibromuscular wall; 2, air sacs. Fl, filament; Cr, cartilage; Wight arrows, lamella.",
+    "bbox": [
+      [
+        183,
+        80,
+        812,
+        768
+      ]
+    ],
+    "page_idx": 47
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_15.jpg",
+    "caption": "Figure R1.5. A schematic diagram of lungfish lung alveolar structure. (A) The previous schematic diagram of lungfish lung alveolar structure shows the transverse section (a). (B) A modified schematic diagram of lungfish lung alveolar structure shows the transverse section (a). The major elements of alveolar septa: alveolar cells, macrophages, capillaries and fibromuscular wall.",
+    "bbox": [
+      [
+        188,
+        428,
+        802,
+        592
+      ]
+    ],
+    "page_idx": 48
+  },
+  {
+    "type": "image",
+    "img_path": "images/Figure_unknown_16.jpg",
+    "caption": "Figure R1.6. The expression patterns in of lungfish macrophage and dendritic cell markers. (A)",
+    "bbox": [
+      [
+        176,
+        501,
+        820,
+        720
+      ]
+    ],
+    "page_idx": 50
+  }
+]