Datasets:
protolyze
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plminterp

Dataset card Data Studio Files
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2
Entry_x
string
Sequence
string
length
int64
mol_weight
float64
iso_point
float64
aromaticity
float64
instability_index
float64
gravy
float64
helix_frac
float64
turn_frac
float64
sheet_frac
float64
count_A
int64
percent_A
float64
count_C
int64
percent_C
float64
count_D
int64
percent_D
float64
count_E
int64
percent_E
float64
count_F
int64
percent_F
float64
count_G
int64
percent_G
float64
count_H
int64
percent_H
float64
count_I
int64
percent_I
float64
count_K
int64
percent_K
float64
count_L
int64
percent_L
float64
count_M
int64
percent_M
float64
count_N
int64
percent_N
float64
count_P
int64
percent_P
float64
count_Q
int64
percent_Q
float64
count_R
int64
percent_R
float64
count_S
int64
percent_S
float64
count_T
int64
percent_T
float64
count_V
int64
percent_V
float64
count_W
int64
percent_W
float64
count_Y
int64
percent_Y
float64
charge_pH7
int64
boman_index
float64
aliphatic_index
float64
hydrophobic_moment
float64
Entry_y
string
Entry Name
string
Protein names
string
Organism
string
Length
int64
Mass
int64
Subcellular location [CC]
string
Gene Ontology (biological process)
string
Gene Ontology (molecular function)
string
EC number
string
Disruption phenotype
string
Catalytic activity
string
Pathway
string
Subcellular location [CC].1
string
Function [CC]
string
Domain [CC]
string
Induction
string
Disruption phenotype.1
string
P55036
MVLESTMVCVDNSEYMRNGDFLPTRLQAQQDAVNIVCHSKTRSNPENNVGLITLANDCEVLTTLTPDTGRILSKLHTVQPKGKITFCTGIRVAHLALKHRQGKNHKMRIIAFVGSPVEDNEKDLVKLAKRLKKEKVNVDIINFGEEEVNTEKLTAFVNTLNGKDGTGSHLVTVPPGPSLADALISSPILAGEGGAMLGLGASDFEFGVDPSADPELALALRVSMEEQRQRQEEEARRAAAASAAEAGIATTGTEDSDDALLKMTISQQEFGRTGLPDLSSMTEEEQIAYAMQMSLQGAEFGQAESADIDASSAMDTSEPA...
377
40,736.2143
4.682248
0.034483
45.759151
-0.457029
0.381963
0.30504
0.291777
38
0.101
4
0.011
28
0.074
35
0.093
10
0.027
27
0.072
6
0.016
16
0.042
24
0.064
34
0.09
13
0.034
18
0.048
16
0.042
17
0.045
15
0.04
26
0.069
24
0.064
23
0.061
0
0
3
0.008
377
40,735.36
-23.369
-0.000574
P55036
PSMD4_HUMAN
26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein)
Homo sapiens (Human)
377
40,737
nan
proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]
identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; polyubiquitin modification-dependent protein binding [GO:0031593]; RNA binding [GO:0003723]
nan
nan
nan
nan
nan
FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose ...
DOMAIN: The 2 UIM motifs are involved in the binding to a multi-ubiquitin chain in a cooperative way. {ECO:0000269|PubMed:15826667, ECO:0000269|PubMed:19683493}.
nan
nan
P54920
MDNSGKEAEAMALLAEAERKVKNSQSFFSGLFGGSSKIEEACEIYARAANMFKMAKNWSAAGNAFCQAAQLHLQLQSKHDAATCFVDAGNAFKKADPQEAINCLMRAIEIYTDMGRFTIAAKHHISIAEIYETELVDIEKAIAHYEQSADYYKGEESNSSANKCLLKVAGYAALLEQYQKAIDIYEQVGTNAMDSPLLKYSAKDYFFKAALCHFCIDMLNAKLAVQKYEELFPAFSDSRECKLMKKLLEAHEEQNVDSYTESVKEYDSISRLDQWLTTMLLRIKKTIQGDEEDLR
295
33,232.3678
5.228699
0.098305
47.337966
-0.347458
0.444068
0.216949
0.301695
41
0.139
8
0.027
17
0.058
28
0.095
13
0.044
11
0.037
7
0.024
17
0.058
26
0.088
26
0.088
10
0.034
12
0.041
3
0.01
14
0.047
8
0.027
21
0.071
9
0.031
8
0.027
2
0.007
14
0.047
295
33,231.49
-10.972
-0.00033
P54920
SNAA_HUMAN
Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha)
Homo sapiens (Human)
295
33,233
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15980433}; Peripheral membrane protein {ECO:0000305|PubMed:15029241}.
apical protein localization [GO:0045176]; brain development [GO:0007420]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; membrane fusion [GO:0061025]; neuron differentiation [GO:0030182]; regulation of synaptic vesicle priming [GO:0010807]; SNARE complex disassembly [...
protein-containing complex binding [GO:0044877]; SNARE binding [GO:0000149]; soluble NSF attachment protein activity [GO:0005483]; syntaxin binding [GO:0019905]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15980433}; Peripheral membrane protein {ECO:0000305|PubMed:15029241}.
FUNCTION: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (Probable). Together with GNA12 promotes CDH5 localization to plasma membrane (PubMed:15980433). {ECO:0000269|PubMed:15980433, ECO:0000305}.
nan
nan
nan
P55263
MAAAEEEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFV...
362
40,544.9599
6.236909
0.088398
39.473508
-0.317956
0.378453
0.234807
0.337017
39
0.108
7
0.019
21
0.058
29
0.08
21
0.058
19
0.052
10
0.028
25
0.069
34
0.094
27
0.075
8
0.022
15
0.041
14
0.039
16
0.044
12
0.033
16
0.044
19
0.052
19
0.052
2
0.006
9
0.025
362
40,544.11
-3.686
-0.000091
P55263
ADK_HUMAN
Adenosine kinase (AK) (EC 2.7.1.20) (Adenosine 5'-phosphotransferase)
Homo sapiens (Human)
362
40,545
SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:19635462}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:19635462}.
AMP salvage [GO:0044209]; dAMP salvage [GO:0106383]; dATP biosynthetic process [GO:0006175]; GMP salvage [GO:0032263]; purine nucleobase metabolic process [GO:0006144]; purine ribonucleoside salvage [GO:0006166]; ribonucleoside monophosphate biosynthetic process [GO:0009156]
adenosine kinase activity [GO:0004001]; ATP binding [GO:0005524]; deoxyadenosine kinase activity [GO:0004136]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]
2.7.1.20
nan
CATALYTIC ACTIVITY: Reaction=adenosine + ATP = AMP + ADP + H(+); Xref=Rhea:RHEA:20824, ChEBI:CHEBI:15378, ChEBI:CHEBI:16335, ChEBI:CHEBI:30616, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=2.7.1.20; Evidence={ECO:0000269|PubMed:21963049, ECO:0000269|PubMed:8577746, ECO:0000269|PubMed:9070863}; PhysiologicalDirection=left...
PATHWAY: Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.
SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:19635462}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:19635462}.
FUNCTION: Catalyzes the phosphorylation of the purine nucleoside adenosine at the 5' position in an ATP-dependent manner. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides. {ECO:0000269|PubMed:21963049, ECO:0000269|PubMed:8577746, ECO:0000269|PubMed:90708...
nan
nan
nan
P54855
MSLKWTSVFLLIQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVTVLTSSASTLVNASKSSAIKLEVYPTSLTKNYLEDSLLKILDRWIYGVSKNTFWSYFSQLQELCWEYYDYSNKLCKDAVLNKKLMMKLQESKFDVILADALNPCGELLAELFNIPFLYSLRFSVGYTFEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIHMLYFDFWFQIYDLKKWDQFYSEVLGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSSGENGIVVFSLGSMISNMSEE...
530
61,035.6172
8.976916
0.128302
33.589075
-0.043208
0.341509
0.258491
0.407547
29
0.055
9
0.017
23
0.043
27
0.051
33
0.062
27
0.051
15
0.028
32
0.06
44
0.083
60
0.113
21
0.04
23
0.043
23
0.043
15
0.028
17
0.032
41
0.077
23
0.043
33
0.062
14
0.026
21
0.04
530
61,034.84
11.186
0.000183
P54855
UDB15_HUMAN
UDP-glucuronosyltransferase 2B15 (UDPGT 2B15) (UGT2B15) (EC 2.4.1.17) (HLUG4) (UDP-glucuronosyltransferase 2B8) (UDPGT 2B8) (UDPGTh-3)
Homo sapiens (Human)
530
61,036
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:23288867}; Single-pass membrane protein {ECO:0000255}.
estrogen metabolic process [GO:0008210]; steroid metabolic process [GO:0008202]; xenobiotic metabolic process [GO:0006805]
glucuronosyltransferase activity [GO:0015020]
2.4.1.17
nan
CATALYTIC ACTIVITY: Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+); Xref=Rhea:RHEA:21032, ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223, ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17; Evidence={ECO:0000269|PubMed:16595710, ECO:0000269|PubMed:18719240...
nan
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:23288867}; Single-pass membrane protein {ECO:0000255}.
FUNCTION: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:16595710, PubMed:18719240, PubMed:2328886...
nan
nan
nan
P54840
MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDL...
703
80,988.1014
6.348483
0.113798
43.977838
-0.39431
0.291607
0.268848
0.378378
40
0.057
11
0.016
43
0.061
49
0.07
40
0.057
41
0.058
28
0.04
36
0.051
37
0.053
64
0.091
15
0.021
27
0.038
34
0.048
22
0.031
46
0.065
44
0.063
40
0.057
46
0.065
12
0.017
28
0.04
703
80,987.36
-8.573
-0.000106
P54840
GYS2_HUMAN
Glycogen [starch] synthase, liver (EC 2.4.1.11) (Glycogen synthase 2)
Homo sapiens (Human)
703
80,989
nan
glycogen biosynthetic process [GO:0005978]; response to glucose [GO:0009749]
alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity [GO:0004373]; glycogen synthase activity, transferring glucose-1-phosphate [GO:0061547]
2.4.1.11
nan
CATALYTIC ACTIVITY: Reaction=[(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + UDP + H(+); Xref=Rhea:RHEA:18549, Rhea:RHEA-COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885; EC=2.4.1.11; Evidence={ECO:0000269|PubMed:1731614, EC...
PATHWAY: Glycan biosynthesis; glycogen biosynthesis. {ECO:0000269|PubMed:1731614, ECO:0000269|PubMed:9691087}.
nan
FUNCTION: Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to ...
nan
nan
nan
P54802
MEAVAVAAAVGVLLLAGAGGAAGDEAREAAAVRALVARLLGPGPAADFSVSVERALAAKPGLDTYSLGGGGAARVRVRGSTGVAAAAGLHRYLRDFCGCHVAWSGSQLRLPRPLPAVPGELTEATPNRYRYYQNVCTQSYSFVWWDWARWEREIDWMALNGINLALAWSGQEAIWQRVYLALGLTQAEINEFFTGPAFLAWGRMGNLHTWDGPLPPSWHIKQLYLQHRVLDQMRSFGMTPVLPAFAGHVPEAVTRVFPQVNVTKMGSWGHFNCSYSCSFLLAPEDPIFPIIGSLFLRELIKEFGTDHIYGADTFNEMQPP...
743
82,264.661
6.19985
0.121131
40.981575
-0.038627
0.332436
0.271871
0.370121
95
0.128
8
0.011
27
0.036
40
0.054
34
0.046
60
0.081
14
0.019
17
0.023
12
0.016
87
0.117
13
0.017
23
0.031
44
0.059
35
0.047
49
0.066
48
0.065
29
0.039
52
0.07
26
0.035
30
0.04
743
82,263.92
-5.696
-0.000069
P54802
ANAG_HUMAN
Alpha-N-acetylglucosaminidase (EC 3.2.1.50) (N-acetyl-alpha-glucosaminidase) (NAG) [Cleaved into: Alpha-N-acetylglucosaminidase 82 kDa form; Alpha-N-acetylglucosaminidase 77 kDa form]
Homo sapiens (Human)
743
82,266
SUBCELLULAR LOCATION: Lysosome.
adult behavior [GO:0030534]; amyloid precursor protein metabolic process [GO:0042982]; aorta morphogenesis [GO:0035909]; astrocyte activation [GO:0048143]; autophagy [GO:0006914]; cardiac muscle cell development [GO:0055013]; cell surface receptor signaling pathway via STAT [GO:0097696]; cellular response to oxidative ...
alpha-N-acetylglucosaminidase activity [GO:0004561]
3.2.1.50
nan
CATALYTIC ACTIVITY: Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides.; EC=3.2.1.50;
nan
SUBCELLULAR LOCATION: Lysosome.
FUNCTION: Involved in the degradation of heparan sulfate.
nan
nan
nan
P54821
MTSSYGHVLERQPALGGRLDSPGNLDTLQAKKNFSVSHLLDLEEAGDMVAAQADENVGEAGRSLLESPGLTSGSDTPQQDNDQLNSEEKKKRKQRRNRTTFNSSQLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFRRNERAMLANKNASLLKSYSGDVTAVEQPIVPRPAPRPTDYLSWGTASPYSAMATYSATCANNSPAQGINMANSIANLRLKAKEYSLQRNQVPTVN
245
27,296.0834
9.48151
0.061224
54.882449
-0.790204
0.326531
0.318367
0.281633
26
0.106
1
0.004
12
0.049
15
0.061
6
0.024
12
0.049
3
0.012
3
0.012
11
0.045
23
0.094
5
0.02
19
0.078
13
0.053
15
0.061
22
0.09
22
0.09
14
0.057
14
0.057
2
0.008
7
0.029
245
27,295.18
6.952
0.000255
P54821
PRRX1_HUMAN
Paired mesoderm homeobox protein 1 (Homeobox protein PHOX1) (Paired-related homeobox protein 1) (PRX-1)
Homo sapiens (Human)
245
27,296
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P63013}.
artery morphogenesis [GO:0048844]; cartilage development [GO:0051216]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic limb morphogenesis [GO:0030326]; inner ear morphogenesis [GO:0042472]; mesenchymal cell proliferation [GO:0010463]; middle ear morphogenesis [GO:0042474]; neuron fate determination [GO...
DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; HMG box domain binding [GO:0071837]; RNA polymerase II cis-reg...
nan
nan
nan
nan
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P63013}.
FUNCTION: Master transcription factor of stromal fibroblasts for myofibroblastic lineage progression. Orchestrates the functional drift of fibroblasts into myofibroblastic phenotype via TGF-beta signaling by remodeling a super-enhancer landscape. Through this function, plays an essential role in wound healing process (...
nan
nan
nan
P54710
MTGLSMDGGGSPKGDVDPFYYDYETVRNGGLIFAGLAFIVGLLILLSRRFRCGGNKKRRQINEDEP
66
7,283.2441
7.8845
0.106061
67.080455
-0.292424
0.257576
0.378788
0.348485
2
0.03
1
0.015
5
0.076
3
0.045
4
0.061
11
0.167
0
0
4
0.061
3
0.045
7
0.106
2
0.03
3
0.045
3
0.045
1
0.015
6
0.091
3
0.045
2
0.03
3
0.045
0
0
3
0.045
66
7,282.29
1.831
0.000251
P54710
ATNG_HUMAN
Sodium/potassium-transporting ATPase subunit gamma (Na(+)/K(+) ATPase subunit gamma) (FXYD domain-containing ion transport regulator 2) (Sodium pump gamma chain)
Homo sapiens (Human)
66
7,283
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}.
cellular hyperosmotic salinity response [GO:0071475]; establishment or maintenance of transmembrane electrochemical gradient [GO:0010248]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; negative regulation of cell population proliferation [GO:0008285]; positive ...
ATPase activator activity [GO:0001671]; protein-macromolecule adaptor activity [GO:0030674]; sodium channel regulator activity [GO:0017080]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}.
FUNCTION: May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.
nan
nan
nan
P55259
MPHLMERMVGSGLLWLALVSCILTQASAVQRGYGNPIEASSYGLDLDCGAPGTPEAHVCFDPCQNYTLLDEPFRSTENSAGSQGCDKNMSGWYRFVGEGGVRMSETCVQVHRCQTDAPMWLNGTHPALGDGITNHTACAHWSGNCCFWKTEVLVKACPGGYHVYRLEGTPWCNLRYCTVPRDPSTVEDKCEKACRPEEECLALNSTWGCFCRQDLNSSDVHSLQPQLDCGPREIKVKVDKCLLGGLGLGEEVIAYLRDPNCSSILQTEERNWVSVTSPVQASACRNILERNQTHAIYKNTLSLVNDFIIRDTILNINFQC...
537
59,479.9005
5.081372
0.080074
47.770577
-0.143762
0.266294
0.307263
0.350093
33
0.061
29
0.054
28
0.052
32
0.06
17
0.032
38
0.071
13
0.024
21
0.039
12
0.022
54
0.101
12
0.022
29
0.054
27
0.05
25
0.047
28
0.052
43
0.08
28
0.052
42
0.078
10
0.019
16
0.03
537
59,479.1
-22.946
-0.000386
P55259
GP2_HUMAN
Pancreatic secretory granule membrane major glycoprotein GP2 (Pancreatic zymogen granule membrane protein GP-2) (ZAP75)
Homo sapiens (Human)
537
59,480
SUBCELLULAR LOCATION: Zymogen granule membrane {ECO:0000250|UniProtKB:P19218}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19218}. Secreted {ECO:0000269|PubMed:10760606}. Cell membrane {ECO:0000250|UniProtKB:P19218}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19218}. Apical cell membrane {ECO:0000250|UniProt...
antigen transcytosis by M cells in mucosal-associated lymphoid tissue [GO:0002412]; innate immune response [GO:0045087]; neutrophil migration [GO:1990266]
antigen binding [GO:0003823]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Zymogen granule membrane {ECO:0000250|UniProtKB:P19218}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19218}. Secreted {ECO:0000269|PubMed:10760606}. Cell membrane {ECO:0000250|UniProtKB:P19218}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19218}. Apical cell membrane {ECO:0000250|UniProt...
FUNCTION: Functions as an intestinal M-cell transcytotic receptor specific for type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M-cells it binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typh...
DOMAIN: Each ZP domain consists of an N-terminal (ZP-N) and C-terminal (ZP-C) region connected by a flexible linker; the linker allows the ZP domain to wrap around the ZP-C subdomain of the preceding subunit. {ECO:0000250|UniProtKB:P07911}.
nan
nan
P54315
MLIFWTITLFLLGAAKGKEVCYEDLGCFSDTEPWGGTAIRPLKILPWSPEKIGTRFLLYTNENPNNFQILLLSDPSTIEASNFQMDRKTRFIIHGFIDKGDESWVTDMCKKLFEVEEVNCICVDWKKGSQATYTQAANNVRVVGAQVAQMLDILLTEYSYPPSKVHLIGHSLGAHVAGEAGSKTPGLSRITGLDPVEASFESTPEEVRLDPSDADFVDVIHTDAAPLIPFLGFGTNQQMGHLDFFPNGGESMPGCKKNALSQIVDLDGIWAGTRDFVACNHLRSYKYYLESILNPDGFAAYPCTSYKSFESDKCFPCPDQ...
467
51,847.1853
5.474072
0.109208
23.328694
-0.252891
0.282655
0.30621
0.379015
29
0.062
13
0.028
27
0.058
28
0.06
28
0.06
39
0.084
10
0.021
26
0.056
29
0.062
39
0.084
7
0.015
22
0.047
25
0.054
16
0.034
15
0.032
30
0.064
35
0.075
26
0.056
8
0.017
15
0.032
467
51,846.38
-11.618
-0.000224
P54315
LIPR1_HUMAN
Inactive pancreatic lipase-related protein 1 (PL-RP1)
Homo sapiens (Human)
467
51,848
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1379598, ECO:0000269|PubMed:19824014}.
cholesterol homeostasis [GO:0042632]; fatty acid biosynthetic process [GO:0006633]; high-density lipoprotein particle remodeling [GO:0034375]; triglyceride catabolic process [GO:0019433]
calcium ion binding [GO:0005509]; lipoprotein lipase activity [GO:0004465]; phospholipase A1 activity [GO:0008970]; triacylglycerol lipase activity [GO:0004806]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1379598, ECO:0000269|PubMed:19824014}.
FUNCTION: May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity). {ECO:0000250, ECO:0000269|PubMed:19824014}.
nan
nan
nan
P55072
MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEV...
806
89,320.7757
5.138154
0.058313
39.696042
-0.347643
0.333747
0.297767
0.322581
65
0.081
12
0.015
62
0.077
68
0.084
31
0.038
63
0.078
10
0.012
59
0.073
47
0.058
69
0.086
20
0.025
32
0.04
43
0.053
26
0.032
58
0.072
40
0.05
32
0.04
53
0.066
3
0.004
13
0.016
806
89,320.05
-25.441
-0.000285
P55072
TERA_HUMAN
Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP)
Homo sapiens (Human)
806
89,322
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:15456787}. Endoplasmic reticulum {ECO:0000269|PubMed:15215856}. Nucleus {ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:26842564}. Cytoplasm, Stress granule {ECO:0000269|PubMed:29804830}. Note=Present in the neuronal hyaline inclusion bodies specifically fou...
aggresome assembly [GO:0070842]; ATP metabolic process [GO:0046034]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cellular response to arsenite ion [GO:1903843]; cellular response to heat [GO:0034605]; cellular response to misfolded protein [GO:0071218]; cytoplasm protein quality control [GO:0140455];...
ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; BAT3 complex binding [GO:1904288]; deubiquitinase activator activity [GO:0035800]; identical protein binding [GO:0042802]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; lipid binding [GO:0008289]; M...
3.6.4.6
nan
CATALYTIC ACTIVITY: Reaction=ATP + H2O = ADP + phosphate + H(+); Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.6; Evidence={ECO:0000269|PubMed:26471729};
nan
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:15456787}. Endoplasmic reticulum {ECO:0000269|PubMed:15215856}. Nucleus {ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:26842564}. Cytoplasm, Stress granule {ECO:0000269|PubMed:29804830}. Note=Present in the neuronal hyaline inclusion bodies specifically fou...
FUNCTION: Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive...
DOMAIN: The PIM (PUB-interaction motif) motif mediates interaction with the PUB domain of RNF31. {ECO:0000269|PubMed:24726327}.
nan
nan
P55072
MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEV...
806
89,320.7757
5.138154
0.058313
39.696042
-0.347643
0.333747
0.297767
0.322581
65
0.081
12
0.015
62
0.077
68
0.084
31
0.038
63
0.078
10
0.012
59
0.073
47
0.058
69
0.086
20
0.025
32
0.04
43
0.053
26
0.032
58
0.072
40
0.05
32
0.04
53
0.066
3
0.004
13
0.016
806
89,320.05
-25.441
-0.000285
Q01853
TERA_MOUSE
Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP)
Mus musculus (Mouse)
806
89,322
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P55072}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P55072}. Nucleus {ECO:0000250|UniProtKB:P55072}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:P55072}. Nucleus {ECO:0000269|PubMed:33590678}. Note=Recruited to the cytoplasmic surface of the endopla...
aggresome assembly [GO:0070842]; ATP metabolic process [GO:0046034]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cellular response to arsenite ion [GO:1903843]; cellular response to heat [GO:0034605]; cellular response to misfolded protein [GO:0071218]; cytoplasm protein quality control [GO:0140455];...
ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; BAT3 complex binding [GO:1904288]; deubiquitinase activator activity [GO:0035800]; identical protein binding [GO:0042802]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; lipid binding [GO:0008289]; M...
3.6.4.6
nan
CATALYTIC ACTIVITY: Reaction=ATP + H2O = ADP + phosphate + H(+); Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.6; Evidence={ECO:0000250|UniProtKB:P55072};
nan
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P55072}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P55072}. Nucleus {ECO:0000250|UniProtKB:P55072}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:P55072}. Nucleus {ECO:0000269|PubMed:33590678}. Note=Recruited to the cytoplasmic surface of the endopla...
FUNCTION: Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive...
DOMAIN: The N-terminal domain shows evolutionary conservation with that of PEX1, and is able to bind phospholipids with a preference for phosphatidylinositol mono- and bisphosphates.; DOMAIN: The PIM (PUB-interaction motif) motif mediates interaction with the PUB domain of RNF31. {ECO:0000250|UniProtKB:P55072}.
nan
nan
P54707
MHQKTPEIYSVELSGTKDIVKTDKGDGKEKYRGLKNNCLELKKKNHKEEFQKELHLDDHKLSNRELEEKYGTDIIMGLSSTRAAELLARDGPNSLTPPKQTPEIVKFLKQMVGGFSILLWVGAFLCWIAYGIQYSSDKSASLNNVYLGCVLGLVVILTGIFAYYQEAKSTNIMSSFNKMIPQQALVIRDSEKKTIPSEQLVVGDIVEVKGGDQIPADIRVLSSQGCRVDNSSLTGESEPQPRSSEFTHENPLETKNICFYSTTCLEGTVTGMVINTGDRTIIGHIASLASGVGNEKTPIAIEIEHFVHIVAGVAVSIGIL...
1,039
115,509.1536
6.123231
0.081809
31.661607
0.015592
0.316651
0.264678
0.405197
73
0.07
15
0.014
54
0.052
64
0.062
41
0.039
69
0.066
20
0.019
97
0.093
68
0.065
98
0.094
26
0.025
45
0.043
37
0.036
37
0.036
40
0.038
70
0.067
64
0.062
77
0.074
12
0.012
32
0.031
1,039
115,508.54
-10.537
-0.000091
P54707
AT12A_HUMAN
Potassium-transporting ATPase alpha chain 2 (HK alpha 2) (Non-gastric H(+)/K(+) ATPase subunit alpha) (EC 7.2.2.19) (Non-gastric Na(+)/K(+) ATPase subunit alpha) (EC 7.2.2.13) (Proton pump) (Sodium pump)
Homo sapiens (Human)
1,039
115,511
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:16914892}; Multi-pass membrane protein {ECO:0000255}.
intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; potassium ion import across plasma membrane [GO:1990573]; proton transmembrane transport [GO:1902600]; regulation of pH [GO:0006885]; sodium ion export across plasma membrane [GO:0036376]
ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; P-type potassium:proton transporter activity [GO:0008900]; P-type sodium:potassium-exchanging transporter activity [GO:0005391]
7.2.2.13; 7.2.2.19
nan
CATALYTIC ACTIVITY: Reaction=K(+)(out) + ATP + H2O + H(+)(in) = K(+)(in) + ADP + phosphate + 2 H(+)(out); Xref=Rhea:RHEA:22044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29103, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.2.2.19; Evidence={ECO:0000269|PubMed:11341842, ECO:0000269|PubMed:748547...
nan
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:16914892}; Multi-pass membrane protein {ECO:0000255}.
FUNCTION: The catalytic subunit of a H(+)/K(+) ATPase and/or Na(+)/K(+) ATPase pump which transports K(+) ions in exchange for Na(+) and/or H(+) ions across the apical membrane of epithelial cells. Uses ATP as an energy source to pump K(+) ions into the cell while transporting Na(+) and/or H(+) ions to the extracellula...
nan
INDUCTION: Up-regulated by inflammatory cytokine IL13. {ECO:0000269|PubMed:29391451}.
nan
P54296
MSLVTVPFYQKRHRHFDQSYRNIQTRYLLDEYASKKRASTQASSQKSLSQRSSSQRASSQTSLGGTICRVCAKRVSTQEDEEQENRSRYQSLVAAYGEAKRQRFLSELAHLEEDVHLARSQARDKLDKYAIQQMMEDKLAWERHTFEERISRAPEILVRLRSHTVWERMSVKLCFTVQGFPTPVVQWYKDGSLICQAAEPGKYRIESNYGVHTLEINRADFDDTATYSAVATNAHGQVSTNAAVVVRRFRGDEEPFRSVGLPIGLPLSSMIPYTHFDVQFLEKFGVTFRREGETVTLKCTMLVTPDLKRVQPRAEWYRDD...
1,465
164,867.3391
5.817948
0.091468
39.09086
-0.448259
0.297611
0.286007
0.348805
95
0.065
27
0.018
91
0.062
113
0.077
58
0.04
93
0.063
37
0.025
66
0.045
94
0.064
106
0.072
28
0.019
44
0.03
71
0.048
59
0.04
82
0.056
120
0.082
83
0.057
122
0.083
23
0.016
53
0.036
1,465
164,866.86
-29.695
-0.00018
P54296
MYOM2_HUMAN
Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2)
Homo sapiens (Human)
1,465
164,869
SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, M line {ECO:0000250}.
extraocular skeletal muscle development [GO:0002074]; muscle contraction [GO:0006936]; sarcomere organization [GO:0045214]
kinase binding [GO:0019900]; structural constituent of muscle [GO:0008307]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, M line {ECO:0000250}.
FUNCTION: Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
nan
nan
nan
P55196
MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCIRVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGERRLDIDEKPLVVQLNWNKDDREGRFVLKNENDAIPPKKAQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKKREKEALRQASDKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRSSDGRPDSGGTLRIYADSLKPNIPYKTILLSTTDPADFAVAEALEKYGLEKENPKDYCIARVMLPPGAQHSDEKGAKEIILD...
1,824
206,801.821
6.061617
0.060855
62.199731
-0.863816
0.332785
0.30318
0.281798
126
0.069
18
0.01
119
0.065
162
0.089
47
0.026
91
0.05
40
0.022
69
0.038
117
0.064
158
0.087
44
0.024
62
0.034
135
0.074
109
0.06
141
0.077
146
0.08
95
0.052
81
0.044
15
0.008
49
0.027
1,824
206,801.47
-23.156
-0.000112
P55196
AFAD_HUMAN
Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)
Homo sapiens (Human)
1,824
206,804
SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000269|PubMed:30463011}. Note=Not found at cell-matrix AJs. {ECO:0000250|UniProtKB:O35889}.
bicellular tight junction assembly [GO:0070830]; cell adhesion [GO:0007155]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell signaling [GO:0007267]; establishment of endothelial intestinal barrier [GO:0090557]; establishment of protein localization to plasma membrane [GO:0061951]; negative regulation of...
actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; cell adhesion molecule binding [GO:0050839]; small GTPase binding [GO:0031267]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000269|PubMed:30463011}. Note=Not found at cell-matrix AJs. {ECO:0000250|UniProtKB:O35889}.
FUNCTION: Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton ...
DOMAIN: The PDZ/DHR domain interacts with the C-terminus of nectin and the Pro-rich C-terminal domain interacts with F-actin.
nan
nan
P55287
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITT...
796
87,964.2473
4.746874
0.079146
36.796608
-0.419598
0.268844
0.331658
0.350503
58
0.073
8
0.01
69
0.087
55
0.069
31
0.039
57
0.072
19
0.024
57
0.072
39
0.049
51
0.064
11
0.014
41
0.052
52
0.065
26
0.033
37
0.046
45
0.057
49
0.062
59
0.074
4
0.005
28
0.035
796
87,963.56
-47.48
-0.00054
P55287
CAD11_HUMAN
Cadherin-11 (OSF-4) (Osteoblast cadherin) (OB-cadherin)
Homo sapiens (Human)
796
87,965
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
adherens junction organization [GO:0034332]; aortic valve formation [GO:0003189]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion mediated by cadherin [GO:0044331];...
beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for proper focal adhesion assembly (PubMed:33811546). Involved in the regulation o...
DOMAIN: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. {ECO:0000250}.
nan
nan
P54198
MKLLKPTWVNHNGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMNNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPKIFKKKQKNGSSAKPSCPYCCCAVGSKDRSLSVWLTCLKRPL...
1,017
111,833.8999
8.397023
0.05998
47.795477
-0.228712
0.320551
0.302852
0.344149
73
0.072
26
0.026
52
0.051
55
0.054
25
0.025
58
0.057
21
0.021
39
0.038
63
0.062
109
0.107
26
0.026
34
0.033
53
0.052
43
0.042
52
0.051
111
0.109
62
0.061
79
0.078
20
0.02
16
0.016
1,017
111,833.28
5.84
0.000052
P54198
HIRA_HUMAN
Protein HIRA (TUP1-like enhancer of split protein 1)
Homo sapiens (Human)
1,017
111,835
SUBCELLULAR LOCATION: Nucleus. Nucleus, PML body. Note=Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence.
anatomical structure morphogenesis [GO:0009653]; chromatin remodeling [GO:0006338]; DNA-templated transcription [GO:0006351]; gastrulation [GO:0007369]; muscle cell differentiation [GO:0042692]; nucleosome assembly [GO:0006334]; osteoblast differentiation [GO:0001649]; regulation of transcription by RNA polymerase II [...
histone binding [GO:0042393]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Nucleus. Nucleus, PML body. Note=Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence.
FUNCTION: Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:00002...
nan
nan
nan
P55809
MAALKLLSSGLRLCASARGSGATWYKGCVCSFSTSAHRHTKFYTDPVEAVKDIPDGATVLVGGFGLCGIPENLIDALLKTGVKGLTAVSNNAGVDNFGLGLLLRSKQIKRMVSSYVGENAEFERQYLSGELEVELTPQGTLAERIRAGGAGVPAFYTPTGYGTLVQEGGSPIKYNKDGSVAIASKPREVREFNGQHFILEEAITGDFALVKAWKADRAGNVIFRKSARNFNLPMCKAAETTVVEVEEIVDIGAFAPEDIHIPQIYVHRLIKGEKYEKRIERLSIRKEGDGEAKSAKPGDDVRERIIKRAALEFEDGMYAN...
520
56,156.9802
7.133373
0.067308
25.424462
-0.1075
0.35
0.288462
0.344231
48
0.092
8
0.015
25
0.048
36
0.069
19
0.037
54
0.104
10
0.019
33
0.063
38
0.073
45
0.087
15
0.029
19
0.037
21
0.04
13
0.025
23
0.044
31
0.06
27
0.052
39
0.075
4
0.008
12
0.023
520
56,156.18
0.157
0.000003
P55809
SCOT1_HUMAN
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (SCOT) (EC 2.8.3.5) (3-oxoacid CoA-transferase 1) (Somatic-type succinyl-CoA:3-oxoacid CoA-transferase) (SCOT-s) (Succinyl-CoA:3-oxoacid CoA transferase)
Homo sapiens (Human)
520
56,158
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:B2GV06}.
adipose tissue development [GO:0060612]; heart development [GO:0007507]; ketone body catabolic process [GO:0046952]; ketone body metabolic process [GO:1902224]; ketone catabolic process [GO:0042182]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; response to act...
identical protein binding [GO:0042802]; succinyl-CoA:3-oxo-acid CoA-transferase activity [GO:0008260]
2.8.3.5
nan
CATALYTIC ACTIVITY: Reaction=a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate; Xref=Rhea:RHEA:24564, ChEBI:CHEBI:30031, ChEBI:CHEBI:35973, ChEBI:CHEBI:57292, ChEBI:CHEBI:90726; EC=2.8.3.5; Evidence={ECO:0000269|PubMed:10964512}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24565; Evidence={ECO:0000305|...
PATHWAY: Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1. {ECO:0000305|PubMed:10964512}.
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:B2GV06}.
FUNCTION: Key enzyme for ketone body catabolism. Catalyzes the first, rate-limiting step of ketone body utilization in extrahepatic tissues, by transferring coenzyme A (CoA) from a donor thiolester species (succinyl-CoA) to an acceptor carboxylate (acetoacetate), and produces acetoacetyl-CoA. Acetoacetyl-CoA is further...
nan
nan
nan
P53804
MDNFAEGDFTVADYALLEDCPHVDDCVFAAEFMSNDYVRVTQLYCDGVGVQYKDYIQSERNLEFDICSIWCSKPISVLQDYCDAIKINIFWPLLFQHQNSSVISRLHPCVDANNSRASEINLKKLQHLELMEDIVDLAKKVANDSFLIGGLLRIGCKIENKILAMEEALNWIKYAGDVTILTKLGSIDNCWPMLSIFFTEYKYHITKIVMEDCNLLEELKTQSCMDCIEEGELMKMKGNEEFSKERFDIAIIYYTRAIEYRPENYLLYGNRALCFLRTGQFRNALGDGKRATILKNTWPKGHYRYCDALSMLGEYDWALQ...
2,025
229,866.3225
7.531075
0.078519
49.13003
-0.589531
0.348148
0.285432
0.315062
120
0.059
55
0.027
105
0.052
176
0.087
76
0.038
91
0.045
47
0.023
118
0.058
199
0.098
180
0.089
30
0.015
100
0.049
109
0.054
98
0.048
84
0.041
173
0.085
74
0.037
107
0.053
21
0.01
62
0.031
2,025
229,866.12
-3.624
-0.000016
P53804
TTC3_HUMAN
E3 ubiquitin-protein ligase TTC3 (EC 2.3.2.27) (Protein DCRR1) (RING finger protein 105) (RING-type E3 ubiquitin transferase TTC3) (TPR repeat protein D) (Tetratricopeptide repeat protein 3) (TPR repeat protein 3)
Homo sapiens (Human)
2,025
229,869
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20059950, ECO:0000269|PubMed:30203323}. Cytoplasm {ECO:0000269|PubMed:30203323}. Golgi apparatus {ECO:0000250|UniProtKB:D3ZSP7}. Note=Nuclear localization may be dependent on the proteolytic cleavage of full length protein in the cytoplasm (PubMed:30203323). This cleava...
protein K48-linked ubiquitination [GO:0070936]; ubiquitin-dependent protein catabolic process [GO:0006511]
ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]
2.3.2.27
nan
CATALYTIC ACTIVITY: Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence={ECO:0000269|PubMed:20059950, ECO:0000269|PubMed:30696809};
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:20059950, ECO:0000269|PubMed:30696809}.
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20059950, ECO:0000269|PubMed:30203323}. Cytoplasm {ECO:0000269|PubMed:30203323}. Golgi apparatus {ECO:0000250|UniProtKB:D3ZSP7}. Note=Nuclear localization may be dependent on the proteolytic cleavage of full length protein in the cytoplasm (PubMed:30203323). This cleava...
FUNCTION: E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains (PubMed:20059950, PubMed:30696809). Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus (PubMed:20059950). Acts as a terminal regulator of Akt signaling afte...
nan
INDUCTION: Up-regulated by TGFB1 signaling. {ECO:0000269|PubMed:30696809}.
nan
P55327
MDCREMDLYEDYQSPFDFDAGVNKSYLYLSPSGNSSPPGSPTLQKFGLLRTDPVPEEGEDVAATISATETLSEEEQEELRRELAKVEEEIQTLSQVLAAKEKHLAEIKRKLGINSLQELKQNIAKGWQDVTATSAYKKTSETLSQAGQKASAAFSSVGSVITKKLEDVKNSPTFKSFEEKVENLKSKVGGTKPAGGDFGEVLNSAANASATTTEPLPEKTQESL
224
24,326.7149
4.789788
0.058036
63.524107
-0.652679
0.40625
0.299107
0.308036
20
0.089
1
0.004
10
0.045
27
0.121
7
0.031
14
0.062
1
0.004
6
0.027
21
0.094
21
0.094
2
0.009
8
0.036
11
0.049
11
0.049
5
0.022
24
0.107
17
0.076
12
0.054
1
0.004
5
0.022
224
24,325.82
-10.127
-0.000416
P55327
TPD52_HUMAN
Tumor protein D52 (Protein N8)
Homo sapiens (Human)
224
24,327
nan
anatomical structure morphogenesis [GO:0009653]; B cell differentiation [GO:0030183]; positive regulation of cell population proliferation [GO:0008284]; secretion [GO:0046903]
calcium ion binding [GO:0005509]; protein homodimerization activity [GO:0042803]
nan
nan
nan
nan
nan
nan
nan
nan
nan
P53618
MTAAENVCYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPELIHDFLVNEKDASCKRNAFMMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPSERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLIVLDRLIELKEHPAHERVLQD...
953
107,141.0207
5.721038
0.057712
37.808814
-0.091186
0.378804
0.242392
0.377754
75
0.079
20
0.021
58
0.061
72
0.076
28
0.029
29
0.03
22
0.023
67
0.07
69
0.072
117
0.123
28
0.029
44
0.046
39
0.041
34
0.036
42
0.044
61
0.064
50
0.052
71
0.075
4
0.004
23
0.024
953
107,140.36
-20.201
-0.000189
P53618
COPB_HUMAN
Coatomer subunit beta (Beta-coat protein) (Beta-COP)
Homo sapiens (Human)
953
107,142
SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus membrane {ECO:0000269|PubMed:11056392, ECO:0000269|PubMed:17451557, ECO:0000269|PubMed:7573041}; Peripheral membrane protein {ECO:0000269|PubMed:17451557, ECO:0000269|PubMed:18385291, ECO:0000269|PubMed:20056612}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, COPI...
endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]
structural molecule activity [GO:0005198]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus membrane {ECO:0000269|PubMed:11056392, ECO:0000269|PubMed:17451557, ECO:0000269|PubMed:7573041}; Peripheral membrane protein {ECO:0000269|PubMed:17451557, ECO:0000269|PubMed:18385291, ECO:0000269|PubMed:20056612}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, COPI...
FUNCTION: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membra...
nan
nan
nan
P55273
MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL
166
17,699.9672
5.691141
0.024096
28.65241
-0.000602
0.373494
0.26506
0.343373
21
0.127
0
0
12
0.072
9
0.054
4
0.024
15
0.09
8
0.048
3
0.018
3
0.018
25
0.151
4
0.024
3
0.018
7
0.042
8
0.048
12
0.072
7
0.042
9
0.054
16
0.096
0
0
0
0
166
17,699.04
-4.67
-0.000264
P55273
CDN2D_HUMAN
Cyclin-dependent kinase 4 inhibitor D (p19-INK4d)
Homo sapiens (Human)
166
17,700
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9482106}. Cytoplasm {ECO:0000269|PubMed:9482106}.
autophagic cell death [GO:0048102]; DNA synthesis involved in DNA repair [GO:0000731]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of intrinsic apoptotic...
cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; protein kinase binding [GO:0019901]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9482106}. Cytoplasm {ECO:0000269|PubMed:9482106}.
FUNCTION: Interacts strongly with CDK4 and CDK6 and inhibits them. {ECO:0000269|PubMed:7739548, ECO:0000269|PubMed:8741839}.
nan
nan
nan
P53567
MSKISQQNSTPGVNGISVIHTQAHASGLQQVPQLVPAGPGGGGKAVAPSKQSKKSSPMDRNSDEYRQRRERNNMAVKKSRLKSKQKAQDTLQRVNQLKEENERLEAKIKLLTKELSVLKDLFLEHAHNLADNVQSISTENTTADGDNAGQ
150
16,408.1944
9.772972
0.013333
45.688667
-0.952
0.346667
0.326667
0.24
12
0.08
0
0
7
0.047
9
0.06
1
0.007
10
0.067
4
0.027
5
0.033
15
0.1
13
0.087
3
0.02
11
0.073
6
0.04
14
0.093
8
0.053
15
0.1
7
0.047
9
0.06
0
0
1
0.007
150
16,407.27
8.153
0.000497
P53567
CEBPG_HUMAN
CCAAT/enhancer-binding protein gamma (C/EBP gamma)
Homo sapiens (Human)
150
16,408
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P53568}.
B cell differentiation [GO:0030183]; DNA-templated transcription [GO:0006351]; enucleate erythrocyte differentiation [GO:0043353]; immune response [GO:0006955]; integrated stress response signaling [GO:0140467]; liver development [GO:0001889]; mRNA metabolic process [GO:0016071]; natural killer cell mediated cytotoxici...
DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; RNA polymerase II cis-regula...
nan
nan
nan
nan
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P53568}.
FUNCTION: Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (PubMed:7665092). Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the ...
nan
nan
nan
P52961
MQMPAMMSLLLVSVGLMEALQAQSHPITRRDLFSQEIQLDMALASFDDQYAGCAAAMTAALPDLNHTEFQANQVYADSWTLASSQWQERQARWPEWSLSPTRPSPPPLGFRDEHGVALLAYTANSPLHKEFNAAVREAGRSRAHYLHHFSFKTLHFLLTEALQLLGSGQRPPRCHQVFRGVHGLRFRPAGPRATVRLGGFASASLKHVAAQQFGEDTFFGIWTCLGAPIKGYSFFPGEEEVLIPPFETFQVINASRLAQGPARIYLRALGKHSTYNCEYIKDKKCKSGPCHLDNSAMGQSPLSAVWSLLLLLWFLVVRAF...
327
36,334.243
8.526089
0.107034
46.081651
-0.113456
0.336391
0.272171
0.33945
37
0.113
6
0.018
11
0.034
15
0.046
20
0.061
23
0.07
13
0.04
8
0.024
9
0.028
41
0.125
8
0.024
7
0.021
23
0.07
19
0.058
20
0.061
25
0.076
13
0.04
14
0.043
7
0.021
8
0.024
327
36,333.38
3.599
0.000099
P52961
NAR1_HUMAN
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 (EC 2.4.2.31) (ADP-ribosyltransferase C2 and C3 toxin-like 1) (ARTC1) (Mono(ADP-ribosyl)transferase 1) (CD antigen CD296)
Homo sapiens (Human)
327
36,335
SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane; Lipid-anchor, GPI-anchor.
nan
NAD+ poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-arginine ADP-ribosyltransferase activity [GO:0106274]; nucleotidyltransferase activity [GO:0016779]
2.4.2.31
nan
CATALYTIC ACTIVITY: Reaction=L-arginyl-[protein] + NAD(+) = N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide + H(+); Xref=Rhea:RHEA:19149, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:15087, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29965, ChEBI:CHEBI:57540, ChEBI:CHEBI:142554; EC=2.4.2.31;
nan
SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane; Lipid-anchor, GPI-anchor.
FUNCTION: Has ADP-ribosyltransferase activity toward GLP1R. {ECO:0000269|PubMed:21901419}.
nan
nan
nan
P52952
MFPSPALTPTPFSVKDILNLEQQQRSLAAAGELSARLEATLAPSSCMLAAFKPEAYAGPEAAAPGLPELRAELGRAPSPAKCASAFPAAPAFYPRAYSDPDPAKDPRAEKKELCALQKAVELEKTEADNAERPRARRRRKPRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRRYKCKRQRQDQTLELVGLPPPPPPPARRIAVPVLVRDGKPCLGDSAPYAPAYGVGLNPYGYNAYPAYPGYGGAACSPGYSCTAAYPAGPSPAQPATAAANNNFVNFGVGDLNAVQSPGIPQSNSGVSTLHG...
324
34,917.2948
9.461267
0.083333
66.035833
-0.464815
0.351852
0.317901
0.262346
52
0.16
7
0.022
10
0.031
17
0.052
10
0.031
20
0.062
1
0.003
5
0.015
15
0.046
28
0.086
2
0.006
11
0.034
41
0.127
17
0.052
25
0.077
21
0.065
10
0.031
15
0.046
2
0.006
15
0.046
324
34,916.43
12.927
0.00037
P52952
NKX25_HUMAN
Homeobox protein Nkx-2.5 (Cardiac-specific homeobox) (Homeobox protein CSX) (Homeobox protein NK-2 homolog E)
Homo sapiens (Human)
324
34,918
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29899023}.
adult heart development [GO:0007512]; aortic valve morphogenesis [GO:0003180]; apoptotic process involved in heart morphogenesis [GO:0003278]; atrial cardiac muscle cell development [GO:0055014]; atrial cardiac muscle tissue development [GO:0003228]; atrial septum morphogenesis [GO:0060413]; atrioventricular node cell ...
chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II...
nan
nan
nan
nan
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29899023}.
FUNCTION: Transcription factor required for the development of the heart and the spleen (PubMed:22560297). During heart development, acts as a transcriptional activator of NPPA/ANF in cooperation with GATA4 (By similarity). May cooperate with TBX2 to negatively modulate expression of NPPA/ANF in the atrioventricular ca...
DOMAIN: The homeobox domain binds to double-stranded DNA (PubMed:22849347). {ECO:0000269|PubMed:22849347}.
nan
nan
P52849
MLQLWKVVRPARQLELHRLILLLIAFSLGSMGFLAYYVSTSPKAKEPLPLPLGDCSSGGAAGPGPARPPVPPRPPRPPETARTEPVVLVFVESAYSQLGQEIVAILESSRFRYSTELAPGRGDMPTLTDNTHGRYVLVIYENLLKYVNLDAWSRELLDRYCVEYGVGIIGFFRAHEHSLLSAQLKGFPLFLHSNLGLRDYQVNPSAPLLHLTRPSRLEPGPLPGDDWTIFQSNHSTYEPVLLASLRPAEPAVPGPVLRRARLPTVVQDLGLHDGIQRVLFGHGLSFWLHKLIFVDAVAYLTGKRLCLDLDRYILVDIDDI...
883
100,873.3654
8.812651
0.11778
46.791993
-0.261042
0.281993
0.289921
0.400906
46
0.052
10
0.011
41
0.046
43
0.049
50
0.057
60
0.068
33
0.037
33
0.037
30
0.034
117
0.133
13
0.015
27
0.031
68
0.077
35
0.04
63
0.071
60
0.068
52
0.059
48
0.054
17
0.019
37
0.042
883
100,872.7
9.772
0.000097
P52849
NDST2_HUMAN
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 (EC 2.8.2.8) (Glucosaminyl N-deacetylase/N-sulfotransferase 2) (NDST-2) (N-heparan sulfate sulfotransferase 2) (N-HSST 2) [Includes: Heparan sulfate N-deacetylase 2 (EC 3.-.-.-); Heparan sulfate N-sulfotransferase 2 (EC 2.8.2.-)]
Homo sapiens (Human)
883
100,875
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparin proteoglycan biosynthetic process [GO:0030210]; mast cell mediated immunity [GO:0002448]; regulation of angiotensin levels in blood [GO:0002002]
deacetylase activity [GO:0019213]; heparan sulfate N-deacetylase activity [GO:0102140]; heparan sulfate N-sulfotransferase activity [GO:0015016]; N-acetylglucosamine deacetylase activity [GO:0050119]
2.8.2.-; 2.8.2.8; 3.-.-.-
nan
CATALYTIC ACTIVITY: Reaction=alpha-D-glucosaminyl-[heparan sulfate](n) + 3'-phosphoadenylyl sulfate = N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + 2 H(+); Xref=Rhea:RHEA:21980, Rhea:RHEA-COMP:9830, Rhea:RHEA-COMP:14602, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI...
PATHWAY: Glycan metabolism; heparan sulfate biosynthesis.; PATHWAY: Glycan metabolism; heparin biosynthesis.
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
FUNCTION: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in hepari...
nan
nan
nan
P54098
MSRLLWRKVAGATVGPGPVPAPGRWVSSSVPASDPSDGQRRRQQQQQQQQQQQQQPQQPQVLSSEGGQLRHNPLDIQMLSRGLHEQIFGQGGEMPGEAAVRRSVEHLQKHGLWGQPAVPLPDVELRLPPLYGDNLDQHFRLLAQKQSLPYLEAANLLLQAQLPPKPPAWAWAEGWTRYGPEGEAVPVAIPEERALVFDVEVCLAEGTCPTLAVAISPSAWYSWCSQRLVEERYSWTSQLSPADLIPLEVPTGASSPTQRDWQEQLVVGHNVSFDRAHIREQYLIQGSRMRFLDTMSMHMAISGLSSFQRSLWIAAKQGKH...
1,239
139,560.415
6.46057
0.082324
51.956578
-0.490315
0.334948
0.274415
0.317998
103
0.083
20
0.016
57
0.046
91
0.073
32
0.026
92
0.074
29
0.023
39
0.031
58
0.047
129
0.104
34
0.027
27
0.022
89
0.072
88
0.071
82
0.066
75
0.061
53
0.043
71
0.057
37
0.03
33
0.027
1,239
139,559.86
-8.912
-0.000064
P54098
DPOG1_HUMAN
DNA polymerase subunit gamma-1 (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (5'-deoxyribose-phosphate lyase) (EC 4.2.99.-) (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha)
Homo sapiens (Human)
1,239
139,562
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:10827171, ECO:0000269|PubMed:18063578}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:18063578}.
base-excision repair [GO:0006284]; base-excision repair, gap-filling [GO:0006287]; DNA metabolic process [GO:0006259]; DNA replication proofreading [GO:0045004]; DNA-templated DNA replication [GO:0006261]; mitochondrial DNA replication [GO:0006264]
3'-5' exonuclease activity [GO:0008408]; 5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; protease binding [GO:0002020]; single-stranded DNA 3'-5' DNA exonuclease activity [GO:0008310]
2.7.7.7; 3.1.11.-; 4.2.99.-
nan
CATALYTIC ACTIVITY: Reaction=DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate; Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:173112; EC=2.7.7.7; Evidence={ECO:0000269|PubMed:10827171, ECO:0000269|PubMed:11477093, ECO:0000269...
nan
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:10827171, ECO:0000269|PubMed:18063578}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:18063578}.
FUNCTION: Catalytic subunit of DNA polymerase gamma solely responsible for replication of mitochondrial DNA (mtDNA). Replicates both heavy and light strands of the circular mtDNA genome using a single-stranded DNA template, RNA primers and the four deoxyribonucleoside triphosphates as substrates (PubMed:11477093, PubMe...
DOMAIN: The polymerase domain encompasses three conserved active site motifs: Pol A (residues 887-896), Pol B (residues 943-958) and Pol C (residues 1134-1141). Binds the incoming dNTPs and undergoes an open to close coformation change to catalyze the formation of phosphodiester bond. {ECO:0000269|PubMed:26056153, ECO:...
nan
nan
P52799
MAVRRDSVWKYCWGVLMVLCRTAISKSIVLEPIYWNSSNSKFLPGQGLVLYPQIGDKLDIICPKVDSKTVGQYEYYKVYMVDKDQADRCTIKKENTPLLNCAKPDQDIKFTIKFQEFSPNLWGLEFQKNKDYYIISTSNGSLEGLDNQEGGVCQTRAMKILMKVGQDASSAGSTRNKDPTRRPELEAGTNGRSSTTSPFVKPNPGSSTDGNSAGHSGNNILGSEVALFAGIASGCIIFIVIIITLVVLLLKYRRRHRKHSPQHTTTLSLSTLATPKRSGNNNGSEPSDIIIPLRTADSVFCPHYEKVSGDYGHPVYIVQE...
333
36,922.7708
9.036872
0.084084
45.298198
-0.35015
0.249249
0.339339
0.36036
15
0.045
8
0.024
17
0.051
13
0.039
9
0.027
25
0.075
6
0.018
25
0.075
24
0.072
25
0.075
6
0.018
18
0.054
21
0.063
13
0.039
15
0.045
32
0.096
20
0.06
22
0.066
4
0.012
15
0.045
333
36,921.92
8.977
0.000243
P52799
EFNB2_HUMAN
Ephrin-B2 (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L)
Homo sapiens (Human)
333
36,923
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28931592}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P52800}.
adherens junction organization [GO:0034332]; anatomical structure morphogenesis [GO:0009653]; animal organ morphogenesis [GO:0009887]; axon guidance [GO:0007411]; blood vessel morphogenesis [GO:0048514]; cell adhesion [GO:0007155]; cell migration involved in sprouting angiogenesis [GO:0002042]; cell-cell signaling [GO:...
ephrin receptor binding [GO:0046875]; virus receptor activity [GO:0001618]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28931592}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P52800}.
FUNCTION: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional sign...
nan
nan
nan
P52789
MIASHLLAYFFTELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLF...
917
102,378.7571
5.7095
0.067612
34.933152
-0.19084
0.343511
0.254089
0.352236
57
0.062
25
0.027
62
0.068
73
0.08
41
0.045
83
0.091
26
0.028
46
0.05
55
0.06
92
0.1
38
0.041
25
0.027
21
0.023
29
0.032
58
0.063
42
0.046
52
0.057
71
0.077
6
0.007
15
0.016
917
102,378.06
-23.779
-0.000232
P52789
HXK2_HUMAN
Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (Muscle form hexokinase)
Homo sapiens (Human)
917
102,380
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:18350175}; Peripheral membrane protein {ECO:0000305}. Cytoplasm, cytosol {ECO:0000269|PubMed:18350175}. Note=The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrial outer membrane (PubMed:29298880). The interaction...
apoptotic mitochondrial changes [GO:0008637]; canonical glycolysis [GO:0061621]; cellular response to leukemia inhibitory factor [GO:1990830]; establishment of protein localization to mitochondrion [GO:0072655]; fructose 6-phosphate metabolic process [GO:0006002]; glucose 6-phosphate metabolic process [GO:0051156]; glu...
ATP binding [GO:0005524]; D-glucose binding [GO:0005536]; fructokinase activity [GO:0008865]; glucokinase activity [GO:0004340]; hexokinase activity [GO:0004396]
2.7.1.1
nan
CATALYTIC ACTIVITY: Reaction=a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+); Xref=Rhea:RHEA:22740, ChEBI:CHEBI:4194, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:229467, ChEBI:CHEBI:456216; EC=2.7.1.1; Evidence={ECO:0000269|PubMed:23185017, ECO:0000269|PubMed:26985301, ECO:0000269|PubMed:29298880}; Physiol...
PATHWAY: Carbohydrate metabolism; hexose metabolism. {ECO:0000305|PubMed:29298880}.; PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4. {ECO:0000305|PubMed:29298880}.
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:18350175}; Peripheral membrane protein {ECO:0000305}. Cytoplasm, cytosol {ECO:0000269|PubMed:18350175}. Note=The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrial outer membrane (PubMed:29298880). The interaction...
FUNCTION: Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose...
DOMAIN: The N- and C-terminal halves of the protein contain a hexokinase domain (PubMed:29298880). In contrast to hexokinase-1 and -3 (HK1 and HK3, respectively), both hexokinase domains display catalytic activity (PubMed:29298880). The region connecting the two hexokinase domains is required for the catalytic activity...
nan
nan
P55157
MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVLLDRGKGKLQDSVGYRISSNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKSIFKGKSPSKIMGKENLEALQRPTLLHLIHGKVKEFYSYQNEAVAIENIKRGLASLFQTQLSSGTTNEVDISGNCKVTYQAHQDKVIKIKALDSCKIARSGFTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGLNFLQTIKGKIVSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKGCPSLSELWRSTRKYLQPDNL...
894
99,350.0112
8.612025
0.074944
42.001465
-0.177069
0.345638
0.269575
0.373602
63
0.07
11
0.012
40
0.045
60
0.067
34
0.038
55
0.062
15
0.017
62
0.069
69
0.077
98
0.11
19
0.021
36
0.04
26
0.029
43
0.048
39
0.044
84
0.094
49
0.055
58
0.065
4
0.004
29
0.032
894
99,349.36
7.87
0.000079
P55157
MTP_HUMAN
Microsomal triglyceride transfer protein large subunit
Homo sapiens (Human)
894
99,351
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:16478722, ECO:0000269|PubMed:22236406, ECO:0000269|PubMed:23475612, ECO:0000269|PubMed:26224785}. Golgi apparatus {ECO:0000269|PubMed:16478722}. Note=Colocalizes with P4HB/PDI in the endoplasmic reticulum (PubMed:23475612, PubMed:26224785). {ECO:0000269|Pu...
cholesterol homeostasis [GO:0042632]; chylomicron assembly [GO:0034378]; circadian rhythm [GO:0007623]; establishment of localization in cell [GO:0051649]; lipid metabolic process [GO:0006629]; lipoprotein metabolic process [GO:0042157]; lipoprotein transport [GO:0042953]; low-density lipoprotein particle remodeling [G...
apolipoprotein binding [GO:0034185]; ceramide 1-phosphate transfer activity [GO:1902388]; cholesterol transfer activity [GO:0120020]; lipid binding [GO:0008289]; lipid transporter activity [GO:0005319]; phosphatidylcholine transfer activity [GO:0120019]; phosphatidylethanolamine transfer activity [GO:1904121]; phosphol...
nan
nan
CATALYTIC ACTIVITY: Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out); Xref=Rhea:RHEA:38571, ChEBI:CHEBI:57643; Evidence={ECO:0000269|PubMed:16478722, ECO:0000269|PubMed:8876250}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38572; Evidence={ECO:0000305|PubMed...
nan
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:16478722, ECO:0000269|PubMed:22236406, ECO:0000269|PubMed:23475612, ECO:0000269|PubMed:26224785}. Golgi apparatus {ECO:0000269|PubMed:16478722}. Note=Colocalizes with P4HB/PDI in the endoplasmic reticulum (PubMed:23475612, PubMed:26224785). {ECO:0000269|Pu...
FUNCTION: Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:15897609, PubMed:16478722, PubMed:22236406, PubMed:23475612, PubMed:25108285, PubMed:26224785, PubMed:8876250, PubMed:8939939). Required for the assembly and secretion of plasma lipoproteins that...
nan
INDUCTION: Positively regulated by cholesterol and negatively regulated by insulin. {ECO:0000269|PubMed:7961826}.
nan
P54289
MAAGCLLALTLTLFQSLLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASNEVVYYNAKDDLDPEKNDSEPGSQRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKD...
1,103
124,566.5287
5.119681
0.104261
35.000562
-0.33282
0.285585
0.31097
0.381686
67
0.061
20
0.018
77
0.07
64
0.058
49
0.044
65
0.059
11
0.01
68
0.062
66
0.06
101
0.092
17
0.015
77
0.07
52
0.047
46
0.042
48
0.044
72
0.065
60
0.054
77
0.07
17
0.015
49
0.044
1,103
124,565.95
-28.712
-0.00023
P54289
CA2D1_HUMAN
Voltage-dependent calcium channel subunit alpha-2/delta-1 (Voltage-gated calcium channel subunit alpha-2/delta-1) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-1; Voltage-dependent calcium channel subunit delta-1]
Homo sapiens (Human)
1,103
124,568
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:35293990}.
calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport via high voltage-gated calcium channel [GO:0061577]; calcium ion transport [GO:0006816]; calcium ion transport into cytosol [GO:0060402]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cellular respon...
metal ion binding [GO:0046872]; voltage-gated calcium channel activity [GO:0005245]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:35293990}.
FUNCTION: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel (PubMed:35293990). Plays an important role in excitation-contraction coupling (By similarity). {ECO:0000250, ECO:0000269|PubMed:35293990}.
DOMAIN: The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch. {ECO:0000250}.
nan
nan
P53674
MSQAAKASASATVAVNPGPDTKGKGAPPAGTSPSPGTTLAPTTVPITSAKAAELPPGNYRLVVFELENFQGRRAEFSGECSNLADRGFDRVRSIIVSAGPWVAFEQSNFRGEMFILEKGEYPRWNTWSSSYRSDRLMSFRPIKMDAQEHKISLFEGANFKGNTIEIQGDDAPSLWVYGFSDRVGSVKVSSGTWVGYQYPGYRGYQYLLEPGDFRHWNEWGAFQPQMQSLRRLRDKQWHLEGSFPVLATEPPK
252
28,023.054
8.589203
0.123016
41.384524
-0.544841
0.269841
0.345238
0.31746
21
0.083
1
0.004
10
0.04
16
0.063
14
0.056
24
0.095
3
0.012
8
0.032
11
0.044
15
0.06
5
0.02
9
0.036
20
0.079
11
0.044
17
0.067
24
0.095
12
0.048
14
0.056
8
0.032
9
0.036
252
28,022.16
2.948
0.000105
P53674
CRBB1_HUMAN
Beta-crystallin B1 (Beta-B1 crystallin)
Homo sapiens (Human)
252
28,023
nan
lens development in camera-type eye [GO:0002088]; visual perception [GO:0007601]
structural constituent of eye lens [GO:0005212]
nan
nan
nan
nan
nan
FUNCTION: Crystallins are the dominant structural components of the vertebrate eye lens.
DOMAIN: Has a two-domain beta-structure, folded into four very similar Greek key motifs.
nan
nan
P52739
MEAEETMECLQEFPEHHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEFTQEPLVEIEGVSKMAFRHLIEFTYTAKLMIQGEEEANDVWKAAEFLQMLEAIKALEVRNKENSAPLEENTTGKNEAKKRKIAETSNVITESLPSAESEPVEIEVEIAEGTIEVEDEGIETLEEVASAKQSVKYIQSTGSSDDSALALLADITSKYRQGDRKGQIKEDGCPSDPTSKQVEGIEIVELQLSHVKDLFHCEKCNRSFKLFYHFKEHMKSHSTESFKCEICNKRYLRESAWKQHLNCYHLEEGGVSKK...
623
71,421.2119
5.101891
0.060995
52.417207
-0.6687
0.373997
0.210273
0.314607
38
0.061
18
0.029
31
0.05
88
0.141
24
0.039
24
0.039
33
0.053
26
0.042
46
0.074
49
0.079
12
0.019
20
0.032
18
0.029
36
0.058
25
0.04
38
0.061
36
0.058
47
0.075
4
0.006
10
0.016
623
71,420.43
-48.391
-0.000678
P52739
ZN131_HUMAN
Zinc finger protein 131
Homo sapiens (Human)
623
71,422
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17306895, ECO:0000269|PubMed:22467880, ECO:0000269|PubMed:23404503}. Note=Sumoylation does not affect nuclear localization.
negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cytokine production [GO:0001817]; regulation of immune system process [GO:0002682]
DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17306895, ECO:0000269|PubMed:22467880, ECO:0000269|PubMed:23404503}. Note=Sumoylation does not affect nuclear localization.
FUNCTION: Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity). May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling. {ECO:0000250, ECO:0000269|PubMed:18847501, ECO:0000269|PubMed:22467880}.
nan
nan
nan
P52597
MMLGPEGGEGFVVKLRGLPWSCSVEDVQNFLSDCTIHDGAAGVHFIYTREGRQSGEAFVELGSEDDVKMALKKDRESMGHRYIEVFKSHRTEMDWVLKHSGPNSADSANDGFVRLRGLPFGCTKEEIVQFFSGLEIVPNGITLPVDPEGKITGEAFVQFASQELAEKALGKHKERIGHRYIEVFKSSQEEVRSYSDPPLKFMSVQRPGPYDRPGTARRYIGIVKQAGLERMRPGAYSTGYGGYEEYSGLSDGYGFTTDLFGRDLSYCLSGMYDHRYGDSEFTVQSTTGHCVHMRGLPYKATENDIYNFFSPLNPVRVHIE...
415
45,671.3475
5.376253
0.106024
37.882892
-0.471566
0.272289
0.33253
0.313253
26
0.063
6
0.014
22
0.053
33
0.08
20
0.048
51
0.123
13
0.031
15
0.036
16
0.039
24
0.058
14
0.034
11
0.027
17
0.041
15
0.036
24
0.058
37
0.089
19
0.046
28
0.067
2
0.005
22
0.053
415
45,670.52
-14.42
-0.000316
P52597
HNRPF_HUMAN
Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed]
Homo sapiens (Human)
415
45,672
SUBCELLULAR LOCATION: Nucleus, nucleoplasm.
mRNA splicing, via spliceosome [GO:0000398]; regulation of RNA splicing [GO:0043484]; RNA processing [GO:0006396]
RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Nucleus, nucleoplasm.
FUNCTION: Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-...
DOMAIN: The N-terminal RRM domains are responsible for recognizing the G-tract of BCL-X RNA.
nan
nan
P54105
MSFLKSFPPPGPAEGLLRQQPDTEAVLNGKGLGTGTLYIAESRLSWLDGSGLGFSLEYPTISLHALSRDRSDCLGEHLYVMVNAKFEEESKEPVADEEEEDSDDDVEPITEFRFVPSDKSALEAMFTAMCECQALHPDPEDEDSDDYDGEEYDVEAHEQGQGDIPTFYTYEEGLSHLTAEGQATLERLEGMLSQSVSSQYNMAGVRTEDSIRDYEDGMEVDTTPTVAGQFEDADVDH
237
26,215.0243
4.050028
0.080169
49.968819
-0.656118
0.341772
0.337553
0.299578
16
0.068
3
0.013
25
0.105
32
0.135
9
0.038
19
0.08
6
0.025
5
0.021
5
0.021
21
0.089
7
0.03
3
0.013
13
0.055
9
0.038
8
0.034
20
0.084
14
0.059
12
0.051
1
0.004
9
0.038
237
26,214.13
-43.219
-0.001649
P54105
ICLN_HUMAN
Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln) (I(Cln)) (Chloride ion current inducer protein) (ClCI) (Reticulocyte pICln)
Homo sapiens (Human)
237
26,215
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21081503}. Nucleus {ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21081503}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18984161}. Note=A small fraction is also associated with the cytoskeleton (PubMed:18984161).
cell volume homeostasis [GO:0006884]; chloride transport [GO:0006821]; mRNA cis splicing, via spliceosome [GO:0045292]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; spliceosomal snRNP assembly [GO:0000387]
RNA binding [GO:0003723]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21081503}. Nucleus {ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21081503}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18984161}. Note=A small fraction is also associated with the cytoskeleton (PubMed:18984161).
FUNCTION: Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (PubMed:10330151, PubMed:11713266, PubMed:18984161, PubMed:21081503). Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosom...
nan
nan
nan
P53701
MGLSPSAPAVAVQASNASASPPSGCPMHEGKMKGCPVNTEPSGPTCEKKTYSVPAHQERAYEYVECPIRGTAAENKENLDPSNLMPPPNQTPAPDQPFALSTVREESSIPRADSEKKWVYPSEQMFWNAMLKKGWKWKDEDISQKDMYNIIRIHNQNNEQAWKEILKWEALHAAECPCGPSLIRFGGKAKEYSPRARIRSWMGYELPFDRHDWIINRCGTEVRYVIDYYDGGEVNKDYQFTILDVRPALDSLSAVWDRMKVAWWRWTS
268
30,601.2463
6.248902
0.104478
60.752239
-0.733955
0.309701
0.320896
0.279851
23
0.086
7
0.026
14
0.052
21
0.078
5
0.019
14
0.052
5
0.019
13
0.049
18
0.067
12
0.045
9
0.034
13
0.049
24
0.09
9
0.034
15
0.056
21
0.078
9
0.034
13
0.049
12
0.045
11
0.041
268
30,600.36
-1.896
-0.000062
P53701
CCHL_HUMAN
Holocytochrome c-type synthase (EC 4.4.1.17) (Cytochrome c-type heme lyase)
Homo sapiens (Human)
268
30,602
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:17033964}. Membrane {ECO:0000269|PubMed:23150584}; Lipid-anchor {ECO:0000305|PubMed:25255805, ECO:0000305|PubMed:25807930}.
animal organ morphogenesis [GO:0009887]; cytochrome c-heme linkage [GO:0018063]; respiratory electron transport chain [GO:0022904]
heme binding [GO:0020037]; holocytochrome-c synthase activity [GO:0004408]; metal ion binding [GO:0046872]
4.4.1.17
nan
CATALYTIC ACTIVITY: Reaction=holo-[cytochrome c] = apo-[cytochrome c] + heme b; Xref=Rhea:RHEA:22648, Rhea:RHEA-COMP:10725, Rhea:RHEA-COMP:10726, ChEBI:CHEBI:29950, ChEBI:CHEBI:60344, ChEBI:CHEBI:83739; EC=4.4.1.17; Evidence={ECO:0000269|PubMed:23150584}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:22650; Evid...
nan
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:17033964}. Membrane {ECO:0000269|PubMed:23150584}; Lipid-anchor {ECO:0000305|PubMed:25255805, ECO:0000305|PubMed:25807930}.
FUNCTION: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome. {ECO:0000269|PubMed:23150584}.
nan
nan
nan
P51970
MPGIVELPTLEELKVDEVKISSAVLKAAAHHYGAQCDKPNKEFMLCRWEEKDPRRCLEEGKLVNKCALDFFRQIKRHCAEPFTEYWTCIDYTGQQLFRHCRKQQAKFDECVLDKLGWVRPDLGELSKVTKVKTDRPLPENPYHSRPRPDPSPEIEGDLQPATHGSRFYFWTK
172
20,104.8154
7.578366
0.098837
55.724477
-0.764535
0.337209
0.244186
0.313953
9
0.052
8
0.047
11
0.064
16
0.093
8
0.047
8
0.047
6
0.035
5
0.029
16
0.093
15
0.087
2
0.012
3
0.017
14
0.081
7
0.041
12
0.07
6
0.035
8
0.047
9
0.052
4
0.023
5
0.029
172
20,103.89
1.001
0.00005
P51970
NDUA8_HUMAN
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (Complex I-19kD) (CI-19kD) (Complex I-PGIV) (CI-PGIV) (NADH-ubiquinone oxidoreductase 19 kDa subunit)
Homo sapiens (Human)
172
20,105
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:21310150}; Peripheral membrane protein {ECO:0000269|PubMed:21310150}. Mitochondrion intermembrane space {ECO:0000269|PubMed:21310150}. Mitochondrion {ECO:0000269|PubMed:23676665}.
aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]
NADH dehydrogenase (ubiquinone) activity [GO:0008137]; protein-containing complex binding [GO:0044877]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:21310150}; Peripheral membrane protein {ECO:0000269|PubMed:21310150}. Mitochondrion intermembrane space {ECO:0000269|PubMed:21310150}. Mitochondrion {ECO:0000269|PubMed:23676665}.
FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371, PubMed:32385911, PubMed:33153867). Complex I functions in the transfer of electrons from NADH to the respiratory chain (PubMed:27626371). The imm...
DOMAIN: Contains four C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds. {ECO:0000305|PubMed:21310150}.
nan
nan
P51970
MPGIVELPTLEELKVDEVKISSAVLKAAAHHYGAQCDKPNKEFMLCRWEEKDPRRCLEEGKLVNKCALDFFRQIKRHCAEPFTEYWTCIDYTGQQLFRHCRKQQAKFDECVLDKLGWVRPDLGELSKVTKVKTDRPLPENPYHSRPRPDPSPEIEGDLQPATHGSRFYFWTK
172
20,104.8154
7.578366
0.098837
55.724477
-0.764535
0.337209
0.244186
0.313953
9
0.052
8
0.047
11
0.064
16
0.093
8
0.047
8
0.047
6
0.035
5
0.029
16
0.093
15
0.087
2
0.012
3
0.017
14
0.081
7
0.041
12
0.07
6
0.035
8
0.047
9
0.052
4
0.023
5
0.029
172
20,103.89
1.001
0.00005
Q0MQB1
NDUA8_PANTR
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (Complex I-19kD) (CI-19kD) (NADH-ubiquinone oxidoreductase 19 kDa subunit)
Pan troglodytes (Chimpanzee)
172
20,105
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P51970}; Peripheral membrane protein {ECO:0000250|UniProtKB:P51970}. Mitochondrion intermembrane space {ECO:0000250|UniProtKB:P51970}. Mitochondrion {ECO:0000250|UniProtKB:P51970}.
mitochondrial electron transport, NADH to ubiquinone [GO:0006120]
protein-containing complex binding [GO:0044877]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P51970}; Peripheral membrane protein {ECO:0000250|UniProtKB:P51970}. Mitochondrion intermembrane space {ECO:0000250|UniProtKB:P51970}. Mitochondrion {ECO:0000250|UniProtKB:P51970}.
FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. ...
DOMAIN: Contains four C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds. {ECO:0000250|UniProtKB:P51970}.
nan
nan
P51970
MPGIVELPTLEELKVDEVKISSAVLKAAAHHYGAQCDKPNKEFMLCRWEEKDPRRCLEEGKLVNKCALDFFRQIKRHCAEPFTEYWTCIDYTGQQLFRHCRKQQAKFDECVLDKLGWVRPDLGELSKVTKVKTDRPLPENPYHSRPRPDPSPEIEGDLQPATHGSRFYFWTK
172
20,104.8154
7.578366
0.098837
55.724477
-0.764535
0.337209
0.244186
0.313953
9
0.052
8
0.047
11
0.064
16
0.093
8
0.047
8
0.047
6
0.035
5
0.029
16
0.093
15
0.087
2
0.012
3
0.017
14
0.081
7
0.041
12
0.07
6
0.035
8
0.047
9
0.052
4
0.023
5
0.029
172
20,103.89
1.001
0.00005
Q0MQB0
NDUA8_GORGO
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (Complex I-19kD) (CI-19kD) (NADH-ubiquinone oxidoreductase 19 kDa subunit)
Gorilla gorilla gorilla (Western lowland gorilla)
172
20,105
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P51970}; Peripheral membrane protein {ECO:0000250|UniProtKB:P51970}. Mitochondrion intermembrane space {ECO:0000250|UniProtKB:P51970}. Mitochondrion {ECO:0000250|UniProtKB:P51970}.
mitochondrial electron transport, NADH to ubiquinone [GO:0006120]
nan
nan
nan
nan
nan
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P51970}; Peripheral membrane protein {ECO:0000250|UniProtKB:P51970}. Mitochondrion intermembrane space {ECO:0000250|UniProtKB:P51970}. Mitochondrion {ECO:0000250|UniProtKB:P51970}.
FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. ...
DOMAIN: Contains four C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds. {ECO:0000250|UniProtKB:P51970}.
nan
nan
P51956
MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKRNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKTNPSRIRIALGNEASTVQEEEQDRKGSH...
506
57,704.0016
6.724473
0.075099
46.920949
-0.605534
0.34585
0.296443
0.328063
24
0.047
9
0.018
25
0.049
44
0.087
16
0.032
29
0.057
14
0.028
26
0.051
40
0.079
54
0.107
13
0.026
31
0.061
25
0.049
19
0.038
27
0.053
40
0.079
24
0.047
24
0.047
8
0.016
14
0.028
506
57,703.2
-1.83
-0.000032
P51956
NEK3_HUMAN
Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (HSPK 36) (Never in mitosis A-related kinase 3) (NimA-related protein kinase 3)
Homo sapiens (Human)
506
57,705
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell projection, axon {ECO:0000250}.
cell division [GO:0051301]; mitotic cell cycle [GO:0000278]; protein phosphorylation [GO:0006468]
ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]
2.7.11.1
nan
CATALYTIC ACTIVITY: Reaction=L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+); Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; CATALYTIC ACTIVITY: Reaction=L-threonyl-[protein]...
nan
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell projection, axon {ECO:0000250}.
FUNCTION: Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells...
nan
nan
nan
P51946
MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLV...
323
37,643.0253
6.726065
0.095975
50.644923
-0.378947
0.393189
0.232198
0.362229
20
0.062
8
0.025
14
0.043
31
0.096
14
0.043
7
0.022
8
0.025
14
0.043
24
0.074
42
0.13
10
0.031
15
0.046
15
0.046
10
0.031
20
0.062
24
0.074
13
0.04
17
0.053
2
0.006
15
0.046
323
37,642.15
-0.93
-0.000025
P51946
CCNH_HUMAN
Cyclin-H (MO15-associated protein) (p34) (p37)
Homo sapiens (Human)
323
37,643
SUBCELLULAR LOCATION: Nucleus.
protein stabilization [GO:0050821]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription initiation at RNA polymerase II promoter [GO:0006367]
cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; kinase activity [GO:0016301]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Nucleus.
FUNCTION: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of th...
nan
nan
nan
P51857
MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFVELLMWRDHPEY...
326
37,376.485
7.139341
0.095092
36.351564
-0.372086
0.319018
0.273006
0.368098
19
0.058
6
0.018
16
0.049
25
0.077
12
0.037
17
0.052
10
0.031
23
0.071
23
0.071
31
0.095
6
0.018
18
0.055
20
0.061
10
0.031
18
0.055
18
0.055
13
0.04
22
0.067
5
0.015
14
0.043
326
37,375.62
0.461
0.000012
P51857
AK1D1_HUMAN
Aldo-keto reductase family 1 member D1 (EC 1.3.1.3) (3-oxo-5-beta-steroid 4-dehydrogenase) (Delta(4)-3-ketosteroid 5-beta-reductase) (Delta(4)-3-oxosteroid 5-beta-reductase)
Homo sapiens (Human)
326
37,377
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:7508385}.
androgen metabolic process [GO:0008209]; bile acid biosynthetic process [GO:0006699]; bile acid catabolic process [GO:0030573]; C21-steroid hormone metabolic process [GO:0008207]; cholesterol catabolic process [GO:0006707]; digestion [GO:0007586]
aldo-keto reductase (NADPH) activity [GO:0004033]; aldose reductase (NADPH) activity [GO:0004032]; Delta4-3-oxosteroid 5beta-reductase activity [GO:0047787]; ketosteroid monooxygenase activity [GO:0047086]; steroid binding [GO:0005496]; steroid dehydrogenase activity [GO:0016229]
1.3.1.3
nan
CATALYTIC ACTIVITY: Reaction=5beta-cholestan-3-one + NADP(+) = cholest-4-en-3-one + NADPH + H(+); Xref=Rhea:RHEA:11524, ChEBI:CHEBI:15378, ChEBI:CHEBI:16074, ChEBI:CHEBI:16175, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.3; Evidence={ECO:0000269|PubMed:18407998, ECO:0000269|PubMed:21255593}; PhysiologicalDirection=r...
nan
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:7508385}.
FUNCTION: Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. C...
nan
nan
nan
P51813
MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKIRCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKYHSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVLKMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDFPDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGNISRSQSEQLLRQKGKEGAFM...
675
78,009.7506
8.70183
0.111111
51.948459
-0.620889
0.315556
0.287407
0.339259
27
0.04
13
0.019
31
0.046
49
0.073
26
0.039
33
0.049
21
0.031
25
0.037
61
0.09
59
0.087
17
0.025
30
0.044
29
0.043
35
0.052
29
0.043
71
0.105
24
0.036
46
0.068
12
0.018
37
0.055
675
78,009.04
9.793
0.000126
P51813
BMX_HUMAN
Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38)
Homo sapiens (Human)
675
78,011
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12832404}. Note=Localizes to the edges of spreading cells when complexed with BCAR1.
adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; B cell receptor signaling pathway [GO:0050853]; cell adhesion [GO:0007155]; intracellular signal transduction [GO:0035556]; mesoderm development [GO:0007498]; phosphatidylinositol biosynthetic process [GO:0006661]; protein autophosphorylation [GO:00...
ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; zinc ion binding [GO:0008270]
2.7.10.2
nan
CATALYTIC ACTIVITY: Reaction=L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+); Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:20101, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:61978, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence={ECO:0000255|PROSITE-ProRule:PRU100...
nan
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12832404}. Note=Localizes to the edges of spreading cells when complexed with BCAR1.
FUNCTION: Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor recepto...
DOMAIN: SH2 domain mediates interaction with RUFY1. {ECO:0000269|PubMed:11751885}.
INDUCTION: Activated by IL6/interleukin-6 through phosphatidylinositol 3-kinase (PI3-kinase) pathway. It is likely that activation occurs through binding of phosphoinositides to the PH domain. {ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:9520419}.
nan
P52798
MRLLPLLRTVLWAAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDIVCPHYEGPGPPEGPETFALYMVDWPGYESCQAEGPRAYKRWVCSLPFGHVQFSEKIQRFTPFSLGFEFLPGETYYYISVPTPESSGQCLRLQVSVCCKERKSESAHPVGSPGESGTSGWRGGDTPSPLCLLLLLLLLILRLLRIL
201
22,385.6156
6.885271
0.109453
54.599005
-0.010448
0.288557
0.328358
0.393035
7
0.035
7
0.035
5
0.025
13
0.065
8
0.04
20
0.1
4
0.02
5
0.025
4
0.02
32
0.159
2
0.01
3
0.015
19
0.095
5
0.025
14
0.07
19
0.095
7
0.035
13
0.065
5
0.025
9
0.045
201
22,384.71
0.067
0.000003
P52798
EFNA4_HUMAN
Ephrin-A4 (EPH-related receptor tyrosine kinase ligand 4) (LERK-4)
Homo sapiens (Human)
201
22,386
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
axon guidance [GO:0007411]; cell-cell signaling [GO:0007267]; ephrin receptor signaling pathway [GO:0048013]
ephrin receptor binding [GO:0046875]; transmembrane-ephrin receptor activity [GO:0005005]
nan
nan
nan
nan
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
FUNCTION: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signalin...
nan
nan
nan
P51817
MEAPGLAQAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPI...
358
40,895.3881
6.36508
0.114525
35.896397
-0.318715
0.324022
0.276536
0.377095
25
0.07
3
0.008
25
0.07
24
0.067
23
0.064
22
0.061
13
0.036
19
0.053
26
0.073
35
0.098
6
0.017
10
0.028
25
0.07
8
0.022
19
0.053
17
0.047
17
0.047
23
0.064
8
0.022
10
0.028
358
40,894.53
-2.944
-0.000072
P51817
PRKX_HUMAN
cAMP-dependent protein kinase catalytic subunit PRKX (PrKX) (Protein kinase X) (Protein kinase X-linked) (Serine/threonine-protein kinase PRKX) (EC 2.7.11.1) (Protein kinase PKX1)
Homo sapiens (Human)
358
40,896
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=cAMP induces nuclear translocation.
angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; cell-substrate adhesion [GO:0031589]; endothelial cell migration [GO:0043542]; endothelial cell proliferation [GO:0001935]; epithelial tube morphogenesis [GO:0060562]; kidney morphogenesis [GO:0060993]; myeloid cell differentiation [GO:0030099]; peptidyl-serine pho...
ATP binding [GO:0005524]; cAMP-dependent protein kinase activity [GO:0004691]; protein serine kinase activity [GO:0106310]
2.7.11.1
nan
CATALYTIC ACTIVITY: Reaction=L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+); Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:10026146, ECO:000026...
nan
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=cAMP induces nuclear translocation.
FUNCTION: Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6...
nan
INDUCTION: Up-regulated by phorbol 12-myristate 13-acetate (PMA). {ECO:0000269|PubMed:16491121, ECO:0000269|PubMed:9860982}.
nan
P51797
MAGCRGSLCCCCRWCCCCGERETRTPEELTILGETQEEEDEILPRKDYESLDYDRCINDPYLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQTSVEECSQKGCLALSLLELLGFNLTFVFLASLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVEKEGPMIHSGSVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCS...
869
97,287.5856
6.385088
0.10702
46.012083
0.117146
0.296893
0.270426
0.41542
44
0.051
25
0.029
31
0.036
53
0.061
56
0.064
65
0.075
16
0.018
41
0.047
33
0.038
103
0.119
25
0.029
33
0.038
39
0.045
31
0.036
46
0.053
67
0.077
51
0.059
73
0.084
10
0.012
27
0.031
869
97,286.89
-7.226
-0.000074
P51797
CLCN6_HUMAN
H(+)/Cl(-) exchange transporter 6 (Chloride channel protein 6) (ClC-6) (Chloride transport protein 6)
Homo sapiens (Human)
869
97,289
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:17534424, ECO:0000269|PubMed:33217309}; Multi-pass membrane protein {ECO:0000269|PubMed:17534424}.
cell volume homeostasis [GO:0006884]; chloride transport [GO:0006821]; monoatomic ion transmembrane transport [GO:0034220]; response to mechanical stimulus [GO:0009612]; signal transduction [GO:0007165]
antiporter activity [GO:0015297]; ATP binding [GO:0005524]; chloride transmembrane transporter activity [GO:0015108]; voltage-gated chloride channel activity [GO:0005247]
nan
nan
CATALYTIC ACTIVITY: Reaction=2 chloride(in) + H(+)(out) = 2 chloride(out) + H(+)(in); Xref=Rhea:RHEA:29567, ChEBI:CHEBI:15378, ChEBI:CHEBI:17996; Evidence={ECO:0000269|PubMed:20466723, ECO:0000269|PubMed:33217309}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29568; Evidence={ECO:0000269|PubMed:20466723, ECO:00...
nan
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:17534424, ECO:0000269|PubMed:33217309}; Multi-pass membrane protein {ECO:0000269|PubMed:17534424}.
FUNCTION: Voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the late endosome lumen. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for proto...
nan
nan
nan
P53365
MTDGILGKAATMEIPIHGNGEARQLPEDDGLEQDLQQVMVSGPNLNETSIVSGGYGGSGDGLIPTGSGRHPSHSTTPSGPGDEVARGIAGEKFDIVKKWGINTYKCTKQLLSERFGRGSRTVDLELELQIELLRETKRKYESVLQLGRALTAHLYSLLQTQHALGDAFADLSQKSPELQEEFGYNAETQKLLCKNGETLLGAVNFFVSSINTLVTKTMEDTLMTVKQYEAARLEYDAYRTDLEELSLGPRDAGTRGRLESAQATFQAHRDKYEKLRGDVAIKLKFLEENKIKVMHKQLLLFHNAVSAYFAGNQKQLEQTL...
341
37,855.2698
5.723709
0.067449
35.58651
-0.53695
0.372434
0.269795
0.340176
24
0.07
2
0.006
16
0.047
31
0.091
11
0.032
32
0.094
8
0.023
13
0.038
23
0.067
43
0.126
6
0.018
12
0.035
12
0.035
22
0.065
17
0.05
20
0.059
23
0.067
14
0.041
2
0.006
10
0.029
341
37,854.42
-5.996
-0.000158
P53365
ARFP2_HUMAN
Arfaptin-2 (ADP-ribosylation factor-interacting protein 2) (Partner of RAC1) (POR1)
Homo sapiens (Human)
341
37,856
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:22981988}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:21239483, ECO:0000269|PubMed:22679020, ECO:0000269|PubMed:26507660, ECO:0000269|PubMed:30917996, ECO:0000269|PubMed:31204568}.
actin cytoskeleton organization [GO:0030036]; intracellular protein transport [GO:0006886]; lamellipodium assembly [GO:0030032]; mitophagy [GO:0000423]; protein localization to phagophore assembly site [GO:0034497]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; ruffle organization [GO:0031529]; s...
cadherin binding [GO:0045296]; GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; identical protein binding [GO:0042802]; membrane curvature sensor activity [GO:0140090]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phospholipid binding [GO:0005543]; protein domain specific binding [GO:0019...
nan
nan
nan
nan
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:22981988}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:21239483, ECO:0000269|PubMed:22679020, ECO:0000269|PubMed:26507660, ECO:0000269|PubMed:30917996, ECO:0000269|PubMed:31204568}.
FUNCTION: Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network (PubMed:26507660). May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2 (PubMed:26507660). Also involved in a...
nan
nan
nan
P51648
MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTD...
485
54,847.174
7.978688
0.090722
38.499629
-0.076082
0.342268
0.243299
0.406186
30
0.062
8
0.016
21
0.043
36
0.074
22
0.045
32
0.066
9
0.019
39
0.08
36
0.074
54
0.111
10
0.021
21
0.043
23
0.047
18
0.037
23
0.047
21
0.043
25
0.052
35
0.072
5
0.01
17
0.035
485
54,846.36
2.105
0.000038
P51648
AL3A2_HUMAN
Aldehyde dehydrogenase family 3 member A2 (EC 1.2.1.3) (EC 1.2.1.94) (Aldehyde dehydrogenase 10) (Fatty aldehyde dehydrogenase) (Microsomal aldehyde dehydrogenase)
Homo sapiens (Human)
485
54,848
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000269|PubMed:9133646}; Single-pass membrane protein {ECO:0000305|PubMed:25047030, ECO:0000305|PubMed:9133646}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:9133646}; Single-pass membrane protein {ECO:0000305|PubMed:25047030, ECO:0000305|PubMed:9133646}; Cytoplasmic ...
aldehyde metabolic process [GO:0006081]; central nervous system development [GO:0007417]; epidermis development [GO:0008544]; fatty acid metabolic process [GO:0006631]; hexadecanal metabolic process [GO:0046458]; peripheral nervous system development [GO:0007422]; phytol metabolic process [GO:0033306]; sesquiterpenoid ...
3-chloroallyl aldehyde dehydrogenase activity [GO:0004028]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; long-chain fatty aldehyde dehydrogenase (NAD+) activity [GO:0050061]; long-chain-alcohol oxidase activity [GO:0046577]; medium-chain fatty aldehyde dehydrogenase (NAD+) activity [GO:0052814]; protein homodim...
1.2.1.3; 1.2.1.94
nan
CATALYTIC ACTIVITY: Reaction=an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+); Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.3; Evidence={ECO:0000269|PubMed:18035827, ECO:0000269|PubMed:18182499, ECO:0000269|Pub...
nan
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000269|PubMed:9133646}; Single-pass membrane protein {ECO:0000305|PubMed:25047030, ECO:0000305|PubMed:9133646}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:9133646}; Single-pass membrane protein {ECO:0000305|PubMed:25047030, ECO:0000305|PubMed:9133646}; Cytoplasmic ...
FUNCTION: Catalyzes the oxidation of medium and long chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length (PubMed:18035827, PubMed:18182499, PubMed:22633490, PubMed:25047030, PubMed:9133646, PubMed:9662422). Responsible for con...
nan
nan
nan
P51795
MAMWQGAMDNRGFQQGSFSSFQNSSSDEDLMDIPATAMDFSMRDDVPPLDREVGEDKSYNGGGIGSSNRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKCPEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNEAKRREVLSAAAAAG...
816
90,784.1479
5.808797
0.109069
38.368517
0.194118
0.305147
0.276961
0.420343
58
0.071
17
0.021
39
0.048
44
0.054
46
0.056
64
0.078
16
0.02
58
0.071
33
0.04
89
0.109
25
0.031
28
0.034
35
0.043
16
0.02
38
0.047
60
0.074
49
0.06
58
0.071
19
0.023
24
0.029
816
90,783.44
-12.992
-0.000143
P51795
CLCN5_HUMAN
H(+)/Cl(-) exchange transporter 5 (Chloride channel protein 5) (ClC-5) (Chloride transporter ClC-5)
Homo sapiens (Human)
816
90,785
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:19019917}; Multi-pass membrane protein {ECO:0000269|PubMed:19019917}. Endosome membrane {ECO:0000269|PubMed:19019917}; Multi-pass membrane protein {ECO:0000269|PubMed:19019917}. Cell membrane {ECO:0000269|PubMed:19019917}; Multi-pass membrane protein {E...
chloride transport [GO:0006821]; endocytosis [GO:0006897]; monoatomic ion transmembrane transport [GO:0034220]; renal system process [GO:0003014]
antiporter activity [GO:0015297]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; voltage-gated chloride channel activity [GO:0005247]
nan
nan
CATALYTIC ACTIVITY: Reaction=2 chloride(in) + H(+)(out) = 2 chloride(out) + H(+)(in); Xref=Rhea:RHEA:29567, ChEBI:CHEBI:15378, ChEBI:CHEBI:17996; Evidence={ECO:0000305|PubMed:20466723};
nan
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:19019917}; Multi-pass membrane protein {ECO:0000269|PubMed:19019917}. Endosome membrane {ECO:0000269|PubMed:19019917}; Multi-pass membrane protein {ECO:0000269|PubMed:19019917}. Cell membrane {ECO:0000269|PubMed:19019917}; Multi-pass membrane protein {E...
FUNCTION: Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (PubMed:20466723). Important for normal acidification of the endosome lumen. May play an important role in renal tubular function. The CLC channel family contains both chloride channels and proton-cou...
nan
nan
nan
P51617
MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCERSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSSIPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILL...
712
76,535.7952
6.181604
0.06882
60.01
-0.280056
0.316011
0.332865
0.299157
77
0.108
17
0.024
25
0.035
44
0.062
21
0.029
57
0.08
16
0.022
20
0.028
19
0.027
77
0.108
8
0.011
12
0.017
73
0.103
38
0.053
43
0.06
70
0.098
32
0.045
35
0.049
14
0.02
14
0.02
712
76,535.07
-7.967
-0.000104
P51617
IRAK1_HUMAN
Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1)
Homo sapiens (Human)
712
76,537
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16690127}. Nucleus {ECO:0000269|PubMed:16690127}. Lipid droplet {ECO:0000250}. Note=Translocates to the nucleus when sumoylated. RSAD2/viperin recruits it to the lipid droplet (By similarity). {ECO:0000250}.
canonical NF-kappaB signal transduction [GO:0007249]; cellular response to heat [GO:0034605]; cellular response to hypoxia [GO:0071456]; innate immune response [GO:0045087]; interleukin-1-mediated signaling pathway [GO:0070498]; interleukin-33-mediated signaling pathway [GO:0038172]; intracellular signal transduction [...
ATP binding [GO:0005524]; heat shock protein binding [GO:0031072]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein se...
2.7.11.1
nan
CATALYTIC ACTIVITY: Reaction=L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+); Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; CATALYTIC ACTIVITY: Reaction=L-threonyl-[protein]...
nan
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16690127}. Nucleus {ECO:0000269|PubMed:16690127}. Lipid droplet {ECO:0000250}. Note=Translocates to the nucleus when sumoylated. RSAD2/viperin recruits it to the lipid droplet (By similarity). {ECO:0000250}.
FUNCTION: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRA...
DOMAIN: The ProST region is composed of many proline and serine residues (more than 20 of each) and some threonines. This region is the site of IRAK-1 hyperphosphorylation. {ECO:0000269|PubMed:14625308}.
nan
nan
P52926
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWPQQVVQKKPAQEETEETSSQESAEED
109
11,831.9087
10.626147
0.009174
84.061468
-1.909174
0.348624
0.348624
0.073394
12
0.11
0
0
1
0.009
12
0.11
0
0
11
0.101
0
0
0
0
13
0.119
0
0
1
0.009
1
0.009
15
0.138
13
0.119
12
0.11
10
0.092
5
0.046
2
0.018
1
0.009
0
0
109
11,830.97
12.989
0.001098
P52926
HMGA2_HUMAN
High mobility group protein HMGI-C (High mobility group AT-hook protein 2)
Homo sapiens (Human)
109
11,832
SUBCELLULAR LOCATION: Nucleus.
adrenal gland development [GO:0030325]; astrocyte differentiation [GO:0048708]; base-excision repair [GO:0006284]; cell division [GO:0051301]; cell proliferation in forebrain [GO:0021846]; chondrocyte differentiation [GO:0002062]; chondrocyte proliferation [GO:0035988]; chromatin organization [GO:0006325]; chromosome c...
5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; C2H2 zinc finger domain binding [GO:0070742]; cAMP response element binding [GO:0035497]; DNA binding, bending [GO:0008301]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; enzyme binding [GO:0019899]; MH1 domain binding [GO:0035501]; MH2 d...
nan
nan
nan
nan
SUBCELLULAR LOCATION: Nucleus.
FUNCTION: Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity). Positively regulat...
nan
nan
nan
P51531
MSTPTDPGAMPHPGPSPGPGPSPGPILGPSPGPGPSPGSVHSMMGPSPGPPSVSHPMPTMGSTDFPQEGMHQMHKPIDGIHDKGIVEDIHCGSMKGTGMRPPHPGMGPPQSPMDQHSQGYMSPHPSPLGAPEHVSSPMSGGGPTPPQMPPSQPGALIPGDPQAMSQPNRGPSPFSPVQLHQLRAQILAYKMLARGQPLPETLQLAVQGKRTLPGLQQQQQQQQQQQQQQQQQQQQQQQPQQQPPQPQTQQQQQPALVNYNRPSGPGPELSGPSTPQKLPVPAPGGRPSPAPPAAAQPPAAAVPGPSVPQPAPGQPSPVLQ...
1,590
181,277.2884
6.756815
0.054717
70.697736
-0.895094
0.355975
0.284906
0.273585
94
0.059
11
0.007
81
0.051
156
0.098
34
0.021
91
0.057
39
0.025
72
0.045
124
0.078
144
0.091
48
0.03
56
0.035
121
0.076
123
0.077
107
0.067
104
0.065
63
0.04
69
0.043
12
0.008
41
0.026
1,590
181,276.89
-5.119
-0.000028
P51531
SMCA2_HUMAN
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SAMRCA2) (EC 3.6.4.-) (BRG1-associated factor 190B) (BAF190B) (Probable global transcription activator SNF2L2) (Protein brahma homolog) (hBRM) (SNF2-alpha)
Homo sapiens (Human)
1,590
181,279
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11259672, ECO:0000269|PubMed:25593309}. Note=Localizes to sites of DNA damage. {ECO:0000269|PubMed:25593309}.
chromatin remodeling [GO:0006338]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA po...
ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone binding [GO:0042393]; hydrolase activity [GO:0016787]; nucleosome array spacer activity [GO:0140750]; transcription cis-regulatory region bindin...
3.6.4.-
nan
CATALYTIC ACTIVITY: Reaction=ATP + H2O = ADP + phosphate + H(+); Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:30339381}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence={ECO:0000305|PubMed:30339381...
nan
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11259672, ECO:0000269|PubMed:25593309}. Note=Localizes to sites of DNA damage. {ECO:0000269|PubMed:25593309}.
FUNCTION: ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucl...
nan
nan
nan
P51532
MSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKGMSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFNQNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPP...
1,647
184,643.4678
7.830475
0.052216
65.125076
-0.838859
0.354584
0.310261
0.265331
105
0.064
10
0.006
82
0.05
153
0.093
34
0.021
120
0.073
42
0.026
67
0.041
130
0.079
141
0.086
55
0.033
50
0.03
146
0.089
97
0.059
107
0.065
113
0.069
69
0.042
74
0.045
11
0.007
41
0.025
1,647
184,643.1
3.156
0.000017
P51532
SMCA4_HUMAN
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 (SMARCA4) (EC 3.6.4.-) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (Transcription activator BRG1)
Homo sapiens (Human)
1,647
184,646
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00549, ECO:0000269|PubMed:20418909, ECO:0000269|PubMed:25593309}. Note=Colocalizes with long non-coding RNA Evf2 in nuclear RNA clouds (By similarity). Localizes to sites of DNA damage (PubMed:25593309). {ECO:0000250|UniProtKB:Q3TKT4, ECO:0000269|PubMed:2559...
chromatin remodeling [GO:0006338]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by ...
ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA polymerase binding [GO:0070182]; helicase activity [GO:0004386]; histone binding [GO:0042393]; hydrolase activity [GO:00167...
3.6.4.-
nan
CATALYTIC ACTIVITY: Reaction=ATP + H2O = ADP + phosphate + H(+); Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:30339381}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence={ECO:0000305|PubMed:30339381...
nan
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00549, ECO:0000269|PubMed:20418909, ECO:0000269|PubMed:25593309}. Note=Colocalizes with long non-coding RNA Evf2 in nuclear RNA clouds (By similarity). Localizes to sites of DNA damage (PubMed:25593309). {ECO:0000250|UniProtKB:Q3TKT4, ECO:0000269|PubMed:2559...
FUNCTION: ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucl...
DOMAIN: The KIKL motif recognizes and binds the NET domain of BRD3. {ECO:0000269|PubMed:29567837}.
nan
nan
P51530
MEQLNELELLMEKSFWEEAELPAELFQKKVVASFPRTVLSTGMDNRYLVLAVNTVQNKEGNCEKRLVITASQSLENKELCILRNDWCSVPVEPGDIIHLEGDCTSDTWIIDKDFGYLILYPDMLISGTSIASSIRCMRRAVLSETFRSSDPATRQMLIGTVLHEVFQKAINNSFAPEKLQELAFQTIQEIRHLKEMYRLNLSQDEIKQEVEDYLPSFCKWAGDFMHKNTSTDFPQMQLSLPSDNSKDNSTCNIEVVKPMDIEESIWSPRFGLKGKIDVTVGVKIHRGYKTKYKIMPLELKTGKESNSIEHRSQVVLYTLL...
1,060
120,413.3845
7.94987
0.071698
44.624443
-0.185849
0.339623
0.260377
0.376415
47
0.044
30
0.028
49
0.046
75
0.071
40
0.038
48
0.045
24
0.023
72
0.068
78
0.074
130
0.123
30
0.028
51
0.048
44
0.042
51
0.048
50
0.047
84
0.079
52
0.049
69
0.065
9
0.008
27
0.025
1,060
120,412.78
1.33
0.000011
P51530
DNA2_HUMAN
DNA replication ATP-dependent helicase/nuclease DNA2 (hDNA2) (DNA replication ATP-dependent helicase-like homolog) [Includes: DNA replication nuclease DNA2 (EC 3.1.-.-); DNA replication ATP-dependent helicase DNA2 (EC 3.6.4.12)]
Homo sapiens (Human)
1,060
120,415
SUBCELLULAR LOCATION: Nucleus. Mitochondrion. Note=Was initially reported to be exclusively mitochondrial (PubMed:18995831). However, it was later shown to localize both in mitochondrion and nucleus (PubMed:19487465). {ECO:0000269|PubMed:18995831, ECO:0000269|PubMed:19487465}.
base-excision repair [GO:0006284]; DNA double-strand break processing [GO:0000729]; DNA geometric change [GO:0032392]; DNA replication [GO:0006260]; DNA replication checkpoint signaling [GO:0000076]; DNA replication, Okazaki fragment processing [GO:0033567]; DNA replication, removal of RNA primer [GO:0043137]; mitochon...
4 iron, 4 sulfur cluster binding [GO:0051539]; 5'-3' DNA helicase activity [GO:0043139]; 5'-flap endonuclease activity [GO:0017108]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; helicase activity [GO:0004386]; metal ion binding [GO:0046872...
3.1.-.-; 3.6.4.12
nan
CATALYTIC ACTIVITY: Reaction=ATP + H2O = ADP + phosphate + H(+); Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence={ECO:0000269|PubMed:16595800};
nan
SUBCELLULAR LOCATION: Nucleus. Mitochondrion. Note=Was initially reported to be exclusively mitochondrial (PubMed:18995831). However, it was later shown to localize both in mitochondrion and nucleus (PubMed:19487465). {ECO:0000269|PubMed:18995831, ECO:0000269|PubMed:19487465}.
FUNCTION: Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap unti...
nan
nan
nan
P51168
MHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRIICEGPKKKAMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNASPFKYSKIKHLLKDLDELMEAVLERILAPELSHANATRNLNFSIWNHTPLVLIDERNPHHPMVLDLFGDNHNGLTSSSASEKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYILQATNIFAQVPQQELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKALPSANPGTEFGLKLILDIGQEDYVPFLASTAGVRLML...
640
72,658.3467
5.889338
0.114063
46.473313
-0.196094
0.289063
0.285938
0.376562
40
0.062
22
0.034
26
0.041
38
0.059
30
0.047
38
0.059
17
0.027
40
0.062
26
0.041
62
0.097
19
0.03
36
0.056
38
0.059
27
0.042
27
0.042
45
0.07
37
0.058
29
0.045
14
0.022
29
0.045
640
72,657.6
-12.732
-0.000175
P51168
SCNNB_HUMAN
Epithelial sodium channel subunit beta (Beta-ENaC) (ENaC subunit beta) (ENaCB) (Epithelial Na(+) channel subunit beta) (Amiloride-sensitive sodium channel subunit beta) (Beta-NaCH) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB)
Homo sapiens (Human)
640
72,659
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:18174164, ECO:0000269|PubMed:7762608}; Multi-pass membrane protein {ECO:0000269|PubMed:30251954, ECO:0000269|PubMed:32729833}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P37090}; Multi-pass membrane protein {ECO:0000269|PubMed:30251954, ECO:0000269...
aldosterone metabolic process [GO:0032341]; artery smooth muscle contraction [GO:0014824]; cellular response to acidic pH [GO:0071468]; cellular response to aldosterone [GO:1904045]; cellular response to vasopressin [GO:1904117]; epithelial fluid transport [GO:0042045]; erythrocyte homeostasis [GO:0034101]; gene expres...
ligand-gated sodium channel activity [GO:0015280]; WW domain binding [GO:0050699]
nan
nan
CATALYTIC ACTIVITY: Reaction=Na(+)(in) = Na(+)(out); Xref=Rhea:RHEA:34963, ChEBI:CHEBI:29101; Evidence={ECO:0000269|PubMed:30251954, ECO:0000269|PubMed:32729833, ECO:0000269|PubMed:7762608, ECO:0000269|PubMed:9792722};
nan
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:18174164, ECO:0000269|PubMed:7762608}; Multi-pass membrane protein {ECO:0000269|PubMed:30251954, ECO:0000269|PubMed:32729833}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P37090}; Multi-pass membrane protein {ECO:0000269|PubMed:30251954, ECO:0000269...
FUNCTION: This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis (PubMed:30251954, PubMed:32729833, PubMed:7762608, PubMed:9792722). ENaC operates in epithelial tissues, where it mediates the electrodiffusion of...
nan
nan
nan
P51512
MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKN...
607
69,520.6201
8.719301
0.130148
36.132834
-0.48369
0.233937
0.324547
0.375618
25
0.041
8
0.013
41
0.068
24
0.04
36
0.059
49
0.081
18
0.03
36
0.059
39
0.064
39
0.064
15
0.025
25
0.041
56
0.092
20
0.033
33
0.054
26
0.043
38
0.063
36
0.059
16
0.026
27
0.044
607
69,519.87
7.457
0.000107
P51512
MMP16_HUMAN
Matrix metalloproteinase-16 (MMP-16) (EC 3.4.24.-) (MMP-X2) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP)
Homo sapiens (Human)
607
69,521
SUBCELLULAR LOCATION: [Isoform Long]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}; Extracellular side {ECO:0000305}. Note=Localized at the cell surface of melanoma cells.; SUBCELLULAR LOCATION: [Isoform Short]: Secreted, extracellular space, extracellular matrix. Cell surface. Note=Lo...
chondrocyte proliferation [GO:0035988]; collagen catabolic process [GO:0030574]; craniofacial suture morphogenesis [GO:0097094]; embryonic cranial skeleton morphogenesis [GO:0048701]; endochondral ossification [GO:0001958]; extracellular matrix organization [GO:0030198]; protein processing [GO:0016485]; proteolysis [GO...
enzyme activator activity [GO:0008047]; metalloaminopeptidase activity [GO:0070006]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]
3.4.24.-
nan
nan
nan
SUBCELLULAR LOCATION: [Isoform Long]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}; Extracellular side {ECO:0000305}. Note=Localized at the cell surface of melanoma cells.; SUBCELLULAR LOCATION: [Isoform Short]: Secreted, extracellular space, extracellular matrix. Cell surface. Note=Lo...
FUNCTION: Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II,...
DOMAIN: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
nan
nan
P51114
MAELTVEVRGSNGAFYKGFIKDVHEDSLTVVFENNWQPERQVPFNEVRLPPPPDIKKEISEGDEVEVYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATYNEIVTFERLRPVNQNKTVKKNTFFKCTVDVPEDLREACANENAHKDFKKAVGACRIFYHPETTQLMILSASEATVKRVNILSDMHLRSIRTKLMLMSRNEEATKHLECTKQLAAAFHEEFVVREDLMGLAIGTHGSNIQQARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEG...
621
69,719.9762
5.838524
0.057971
54.764622
-0.776973
0.307568
0.307568
0.297907
38
0.061
6
0.01
39
0.063
63
0.101
18
0.029
47
0.076
12
0.019
28
0.045
38
0.061
39
0.063
13
0.021
33
0.053
24
0.039
21
0.034
54
0.087
48
0.077
34
0.055
48
0.077
4
0.006
14
0.023
621
69,719.18
-9.438
-0.000135
P51114
FXR1_HUMAN
RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p)
Homo sapiens (Human)
621
69,721
SUBCELLULAR LOCATION: Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000269|PubMed:32706158, ECO:0000269|PubMed:39106863}. Cytoplasm, Stress granule {ECO:0000269|PubMed:20417602}. Cytoplasm {ECO:0000269|PubMed:30770808, ECO:0000269|PubMed:7781595, ECO:0000269|PubMed:9259278}. Cell projection, dendrite {ECO:0000...
animal organ development [GO:0048513]; apoptotic process [GO:0006915]; dentate gyrus development [GO:0021542]; membraneless organelle assembly [GO:0140694]; mRNA destabilization [GO:0061157]; mRNA transport [GO:0051028]; muscle organ development [GO:0007517]; negative regulation of inflammatory response [GO:0050728]; n...
molecular condensate scaffold activity [GO:0140693]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA strand a...
nan
nan
nan
nan
SUBCELLULAR LOCATION: Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000269|PubMed:32706158, ECO:0000269|PubMed:39106863}. Cytoplasm, Stress granule {ECO:0000269|PubMed:20417602}. Cytoplasm {ECO:0000269|PubMed:30770808, ECO:0000269|PubMed:7781595, ECO:0000269|PubMed:9259278}. Cell projection, dendrite {ECO:0000...
FUNCTION: mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis (PubMed:17382880, PubMed:20417602, PubMed:30067974, PubMed:34731628, PubMed:35989368, PubMed:36306353). Specifically bi...
DOMAIN: The tandem Agenet-like domains preferentially recognize trimethylated histone peptides. {ECO:0000269|PubMed:21072162}.; DOMAIN: Disordered region at the C-terminus undergoes liquid-liquid phase separation (LLPS) for the formation of a membraneless compartment that stores mRNAs. {ECO:0000250|UniProtKB:Q61584}.; ...
INDUCTION: By Interleukin-19 (IL19). {ECO:0000269|PubMed:30067974}.
nan
P52732
MASQPNSSAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRIL...
1,056
119,157.6036
5.469412
0.045455
44.903788
-0.539015
0.371212
0.255682
0.352273
49
0.046
18
0.017
49
0.046
116
0.11
28
0.027
45
0.043
25
0.024
62
0.059
90
0.085
119
0.113
18
0.017
61
0.058
26
0.025
54
0.051
44
0.042
89
0.084
78
0.074
65
0.062
3
0.003
17
0.016
1,056
119,156.99
-31.744
-0.000266
P52732
KIF11_HUMAN
Kinesin-like protein KIF11 (Kinesin-like protein 1) (Kinesin-like spindle protein HKSP) (Kinesin-related motor protein Eg5) (Thyroid receptor-interacting protein 5) (TR-interacting protein 5) (TRIP-5)
Homo sapiens (Human)
1,056
119,159
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:23857769}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:37728657}.
cell division [GO:0051301]; microtubule-based movement [GO:0007018]; mitotic cell cycle [GO:0000278]; mitotic centrosome separation [GO:0007100]; mitotic spindle assembly [GO:0090307]; mitotic spindle organization [GO:0007052]; regulation of mitotic centrosome separation [GO:0046602]; spindle elongation [GO:0051231]; s...
ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; plus-end-directed microtubule motor activity [GO:0008574]; protein kinase binding [GO:0019901]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:23857769}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:37728657}.
FUNCTION: Motor protein required for establishing a bipolar spindle and thus contributing to chromosome congression during mitosis (PubMed:19001501, PubMed:37728657). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). {ECO:0000269|PubMed:19001...
nan
nan
nan
P55000
MASRWAVQLLLVAAWSMGCGEALKCYTCKEPMTSASCRTITRCKPEDTACMTTLVTVEAEYPFNQSPVVTRSCSSSCVATDPDSIGAAHLIFCCFRDLCNSEL
103
11,185.8674
5.212102
0.067961
53.285437
0.201942
0.31068
0.242718
0.339806
11
0.107
11
0.107
4
0.039
6
0.058
3
0.029
3
0.029
1
0.01
3
0.029
3
0.029
8
0.078
4
0.039
2
0.019
5
0.049
2
0.019
5
0.049
11
0.107
10
0.097
7
0.068
2
0.019
2
0.019
103
11,184.92
-2.664
-0.000238
P55000
SLUR1_HUMAN
Secreted Ly-6/uPAR-related protein 1 (SLURP-1) (ARS component B) (ARS(component B)-81/S) (Anti-neoplastic urinary protein) (ANUP)
Homo sapiens (Human)
103
11,186
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:14506129, ECO:0000269|PubMed:25919322, ECO:0000269|PubMed:26905431}.
cell activation [GO:0001775]; cell adhesion [GO:0007155]; locomotory behavior [GO:0007626]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of keratinocyte proliferation [GO:0010839]; neuromuscular process controlling posture [GO...
acetylcholine receptor activator activity [GO:0030549]; cytokine activity [GO:0005125]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:14506129, ECO:0000269|PubMed:25919322, ECO:0000269|PubMed:26905431}.
FUNCTION: Has an antitumor activity (PubMed:8742060). Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin (PubMed:14721776, PubMed:17008884). In vitro down-regulates keratinocyte proliferation; the func...
nan
INDUCTION: Regulated by retinoic acid, EGF and IFNG/IFN-gamma (PubMed:14721776). Down-regulated by IL-13 in cultured human bronchial epithelial cells (related to asthmatic condition) (PubMed:20621062). {ECO:0000269|PubMed:14721776, ECO:0000269|PubMed:20621062}.
nan
P50897
MASPGCLWLLAVALLPWTCASRALQHLDPPAPLPLVIWHGMGDSCCNPLSMGAIKKMVEKKIPGIYVLSLEIGKTLMEDVENSFFLNVNSQVTTVCQALAKDPKLQQGYNAMGFSQGGQFLRAVAQRCPSPPMINLISVGGQHQGVFGLPRCPGESSHICDFIRKTLNAGAYSKVVQERLVQAEYWHDPIKEDVYRNHSIFLADINQERGINESYKKNLMALKKFVMVKFLNDSIVDPVDSEWFGFYRSGQAKETIPLQETSLYTQDRLGLKEMDNAGQLVFLATEGDHLQLSEEWFYAHIIPFLG
306
34,193.1195
6.070541
0.094771
41.216732
-0.08366
0.323529
0.287582
0.356209
21
0.069
8
0.026
14
0.046
17
0.056
14
0.046
23
0.075
8
0.026
17
0.056
17
0.056
34
0.111
10
0.033
13
0.042
18
0.059
18
0.059
10
0.033
20
0.065
9
0.029
20
0.065
6
0.02
9
0.029
306
34,192.26
-3.922
-0.000115
P50897
PPT1_HUMAN
Palmitoyl-protein thioesterase 1 (PPT-1) (EC 3.1.2.2) (EC 3.1.2.22) (Palmitoyl-protein hydrolase 1)
Homo sapiens (Human)
306
34,193
SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:19941651, ECO:0000269|PubMed:26731412}. Secreted {ECO:0000269|PubMed:26731412}. Golgi apparatus {ECO:0000269|PubMed:26731412}. Endoplasmic reticulum {ECO:0000269|PubMed:26731412}.
adult locomotory behavior [GO:0008344]; associative learning [GO:0008306]; brain development [GO:0007420]; endocytosis [GO:0006897]; fatty-acyl-CoA biosynthetic process [GO:0046949]; grooming behavior [GO:0007625]; lipid catabolic process [GO:0016042]; lysosomal lumen acidification [GO:0007042]; membrane raft organizat...
long-chain fatty acyl-CoA hydrolase activity [GO:0052816]; lysophosphatidic acid binding [GO:0035727]; palmitoyl-(protein) hydrolase activity [GO:0008474]; sulfatide binding [GO:0120146]
3.1.2.2; 3.1.2.22
nan
CATALYTIC ACTIVITY: Reaction=S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+); Xref=Rhea:RHEA:19233, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:74151; EC=3.1.2.22; Evidence={ECO:0000269|PubMe...
nan
SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:19941651, ECO:0000269|PubMed:26731412}. Secreted {ECO:0000269|PubMed:26731412}. Golgi apparatus {ECO:0000269|PubMed:26731412}. Endoplasmic reticulum {ECO:0000269|PubMed:26731412}.
FUNCTION: Has thioesterase activity against fatty acid thioesters with 14 -18 carbons, including palmitoyl-CoA, S-palmitoyl-N-acetylcysteamine, and palmitoylated proteins (PubMed:12855696, PubMed:26731412, PubMed:8816748). In contrast to PPT2, PPT1 can hydrolyze palmitoylated proteins and palmitoylcysteine (PubMed:1285...
nan
nan
nan
P50993
MGRGAGREYSPAATTAENGGGKKKQKEKELDELKKEVAMDDHKLSLDELGRKYQVDLSKGLTNQRAQDVLARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAAMEDEPSNDNLYLGVVLAAVVIVTGCFSYYQEAKSSKIMDSFKNMVPQQALVIREGEKMQINAEEVVVGDLVEVKGGDRVPADLRIISSHGCKVDNSSLTGESEPQTRSPEFTHENPLETRNICFFSTNCVEGTARGIVIATGDRTVMGRIATLASGLEVGRTPIAMEIEHFIQLITGVAVFLGVSFFVLSLILGYSWLEAVI...
1,020
112,264.1906
5.473788
0.07451
33.332647
-0.014216
0.32451
0.271569
0.377451
81
0.079
23
0.023
55
0.054
68
0.067
43
0.042
79
0.077
12
0.012
76
0.075
56
0.055
96
0.094
30
0.029
39
0.038
42
0.041
38
0.037
50
0.049
62
0.061
63
0.062
74
0.073
11
0.011
22
0.022
1,020
112,263.55
-19.075
-0.00017
P50993
AT1A2_HUMAN
Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-2)
Homo sapiens (Human)
1,020
112,265
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:7711835}; Multi-pass membrane protein {ECO:0000269|PubMed:7711835}. Cell membrane {ECO:0000269|PubMed:7711835}; Multi-pass membrane protein {ECO:0000269|PubMed:7711835}.
adult locomotory behavior [GO:0008344]; amygdala development [GO:0021764]; ATP metabolic process [GO:0046034]; behavioral fear response [GO:0001662]; cardiac muscle contraction [GO:0060048]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cellular response to mechanical stimulus [...
ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; P-type sodium:potassium-exchanging transporter activity [GO:0005391]; phosphatase activity [GO:0016791]; potassium ion binding [GO:0030955]; protein heterodimerization activi...
7.2.2.13
nan
CATALYTIC ACTIVITY: Reaction=K(+)(out) + Na(+)(in) + ATP + H2O = K(+)(in) + Na(+)(out) + ADP + phosphate + H(+); Xref=Rhea:RHEA:18353, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101, ChEBI:CHEBI:29103, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.2.2.13;
nan
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:7711835}; Multi-pass membrane protein {ECO:0000269|PubMed:7711835}. Cell membrane {ECO:0000269|PubMed:7711835}; Multi-pass membrane protein {ECO:0000269|PubMed:7711835}.
FUNCTION: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrient...
nan
nan
nan
P54845
MALPPSPLAMEYVNDFDLMKFEVKREPSEGRPGPPTASLGSTPYSSVPPSPTFSEPGMVGATEGTRPGLEELYWLATLQQQLGAGEALGLSPEEAMELLQGQGPVPVDGPHGYYPGSPEETGAQHVQLAERFSDAALVSMSVRELNRQLRGCGRDEALRLKQRRRTLKNRGYAQACRSKRLQQRRGLEAERARLAAQLDALRAEVARLARERDLYKARCDRLTSSGPGSGDPSHLFL
237
25,940.0067
7.728591
0.054852
64.102954
-0.624051
0.367089
0.312236
0.261603
24
0.101
3
0.013
9
0.038
21
0.089
5
0.021
23
0.097
3
0.013
0
0
6
0.025
30
0.127
6
0.025
3
0.013
21
0.089
13
0.055
25
0.105
18
0.076
9
0.038
10
0.042
1
0.004
7
0.03
237
25,939.1
1.649
0.000064
P54845
NRL_HUMAN
Neural retina-specific leucine zipper protein (NRL)
Homo sapiens (Human)
237
25,940
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11477108}. Nucleus {ECO:0000269|PubMed:11477108, ECO:0000269|PubMed:17335001}.
positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; retinal rod cell development [GO:0046548]; visual perception [GO:0007601]
DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; leucine zipper domain binding [GO:0043522]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulat...
nan
nan
nan
nan
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11477108}. Nucleus {ECO:0000269|PubMed:11477108, ECO:0000269|PubMed:17335001}.
FUNCTION: Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B (PubMed:21981118). Also functions as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3 (PubMed:17335001). Binds to the rhodopsin p...
DOMAIN: The minimal transactivation domain (MTD) is conserved across the MAF family, it may activate transcription by recruiting TBP and associated factors at the promoters of target genes. {ECO:0000269|PubMed:15328344}.
nan
nan
P51884
MSLSAFTLFLALIGGTSGQYYDYDFPLSIYGQSSPNCAPECNCPESYPSAMYCDELKLKSVPMVPPGIKYLYLRNNQIDHIDEKAFENVTDLQWLILDHNLLENSKIKGRVFSKLKQLKKLHINHNNLTESVGPLPKSLEDLQLTHNKITKLGSFEGLVNLTFIHLQHNRLKEDAVSAAFKGLKSLEYLDLSFNQIARLPSGLPVSLLTLYLDNNKISNIPDEYFKRFNALQYLRLSHNELADSGIPGNSFNVSSLVELDLSYNKLKNIPTVNENLENYYLEVNQLEKFDIKSFCKILGPLSYSKIKHLRLDGNRISETS...
338
38,428.54
6.156083
0.094675
45.742899
-0.276331
0.346154
0.328402
0.387574
12
0.036
6
0.018
17
0.05
21
0.062
14
0.041
15
0.044
9
0.027
19
0.056
25
0.074
55
0.163
4
0.012
30
0.089
18
0.053
10
0.03
9
0.027
31
0.092
11
0.033
14
0.041
1
0.003
17
0.05
338
38,427.7
-3.59
-0.000093
P51884
LUM_HUMAN
Lumican (Keratan sulfate proteoglycan lumican) (KSPG lumican)
Homo sapiens (Human)
338
38,429
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
cartilage development [GO:0051216]; collagen fibril organization [GO:0030199]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta1 production [GO:0032914]; response to growth factor [GO:0070848]; visual perception [GO:0007601]
collagen binding [GO:0005518]; extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring compression resistance [GO:0030021]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
nan
nan
nan
nan
P50553
MESSAKMESGGAGQQPQPQPQQPFLPPAACFFATAAAAAAAAAAAAAQSAQQQQQQQQQQQQAPQLRPAADGQPSGGGHKSAPKQVKRQRSSSPELMRCKRRLNFSGFGYSLPQQQPAAVARRNERERNRVKLVNLGFATLREHVPNGAANKKMSKVETLRSAVEYIRALQQLLDEHDAVSAAFQAGVLSPTISPNYSNDLNSMAGSPVSSYSSDEGSYDPLSPEEQELLDFTNWF
236
25,453.9532
8.925986
0.063559
87.244068
-0.697034
0.338983
0.317797
0.207627
36
0.153
2
0.008
7
0.03
13
0.055
9
0.038
14
0.059
3
0.013
2
0.008
9
0.038
17
0.072
5
0.021
10
0.042
19
0.081
30
0.127
14
0.059
25
0.106
5
0.021
10
0.042
1
0.004
5
0.021
236
25,453.06
3.801
0.000149
P50553
ASCL1_HUMAN
Achaete-scute homolog 1 (ASH-1) (hASH1) (Class A basic helix-loop-helix protein 46) (bHLHa46)
Homo sapiens (Human)
236
25,454
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q02067}.
adrenal chromaffin cell differentiation [GO:0061104]; carotid body glomus cell differentiation [GO:0061103]; cell maturation [GO:0048469]; cellular response to magnetism [GO:0071259]; central nervous system neuron development [GO:0021954]; cerebral cortex development [GO:0021987]; cerebral cortex GABAergic interneuron ...
bHLH transcription factor binding [GO:0043425]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding...
nan
nan
nan
nan
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q02067}.
FUNCTION: Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes. The c...
nan
nan
nan
P50479
MPHSVTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELMTHLEAQNRIKGCHDHLTLSVSRPEGRSWPSAPDDSKAQAHRIHIDPEIQDGSPTTSRRPSGTGTGPEDGRPSLGSPYGQPPRFPVPHNGSSEATLPAQMSTLHVSPPPSADPARGLPRSRDCRVDLGSEVYRMLREPAEPVAAEPKQSGSFRYLQGMLEAGEGGDWPGPGGPRNLKPTASKLGAPLSGLQGLPECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYCESHAKARVKPPEGYDVVA...
330
35,397.6097
8.069975
0.054545
54.238788
-0.525758
0.278788
0.375758
0.263636
26
0.079
9
0.027
16
0.048
19
0.058
7
0.021
36
0.109
12
0.036
9
0.027
12
0.036
29
0.088
6
0.018
6
0.018
37
0.112
10
0.03
25
0.076
29
0.088
14
0.042
17
0.052
3
0.009
8
0.024
330
35,396.75
2.097
0.000059
P50479
PDLI4_HUMAN
PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein)
Homo sapiens (Human)
330
35,398
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21636573}. Nucleus {ECO:0000269|PubMed:10826496, ECO:0000269|PubMed:21636573}. Cytoplasm {ECO:0000269|PubMed:21636573}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19307596}. Cell projection, lamellipodium {ECO:0000269|PubMed:10826496}...
actin cytoskeleton organization [GO:0030036]; excitatory chemical synaptic transmission [GO:0098976]; heart development [GO:0007507]; muscle structure development [GO:0061061]
actin binding [GO:0003779]; alpha-actinin binding [GO:0051393]; metal ion binding [GO:0046872]; muscle alpha-actinin binding [GO:0051371]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]
nan
nan
nan
nan
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21636573}. Nucleus {ECO:0000269|PubMed:10826496, ECO:0000269|PubMed:21636573}. Cytoplasm {ECO:0000269|PubMed:21636573}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19307596}. Cell projection, lamellipodium {ECO:0000269|PubMed:10826496}...
FUNCTION: [Isoform 1]: Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle (PubMed:19307596). Involved in ...
nan
INDUCTION: [Isoform 2]: Expression is up-regulated by UV irradiation and to a lesser extent by oxidative stress. {ECO:0000269|PubMed:21636573}.
nan
P50552
MSETVICSSRATVMLYDDGNKRWLPAGTGPQAFSRVQIYHNPTANSFRVVGRKMQPDQQVVINCAIVRGVKYNQATPNFHQWRDARQVWGLNFGSKEDAAQFAAGMASALEALEGGGPPPPPALPTWSVPNGPSPEEVEQQKRQQPGPSEHIERRVSNAGGPPAPPAGGPPPPPGPPPPPGPPPPPGLPPSGVPAAAHGAGGGPPPAPPLPAAQGPGGGGAGAPGLAAAIAGAKLRKVSKQEEASGGPTAPKAESGRSGGGGLMEEMNAMLARRRKATQVGEKTPKDESANQEEPEARVPAQSESVRRPWEKNSTTLPRM...
380
39,829.2591
9.047058
0.039474
78.957632
-0.748158
0.310526
0.389474
0.207895
42
0.111
3
0.008
8
0.021
30
0.079
6
0.016
42
0.111
4
0.011
8
0.021
20
0.053
18
0.047
8
0.021
12
0.032
56
0.147
23
0.061
23
0.061
30
0.079
15
0.039
23
0.061
5
0.013
4
0.011
380
39,828.42
5.694
0.000143
P50552
VASP_HUMAN
Vasodilator-stimulated phosphoprotein (VASP)
Homo sapiens (Human)
380
39,830
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell junction, tight junction {ECO:0000250}. Cell projection, lamellipodium membrane. Cell projection, filopodium membrane. Note=Targeted to stress fibers and focal adhesions through interaction with a number of proteins including ...
actin polymerization or depolymerization [GO:0008154]; axon guidance [GO:0007411]; neural tube closure [GO:0001843]; positive regulation of actin filament polymerization [GO:0030838]; protein homotetramerization [GO:0051289]
actin binding [GO:0003779]; cadherin binding [GO:0045296]; profilin binding [GO:0005522]; SH3 domain binding [GO:0017124]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell junction, tight junction {ECO:0000250}. Cell projection, lamellipodium membrane. Cell projection, filopodium membrane. Note=Targeted to stress fibers and focal adhesions through interaction with a number of proteins including ...
FUNCTION: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of g...
DOMAIN: The EVH2 domain is comprised of 3 regions. Block A is a thymosin-like domain required for G-actin binding. The KLKR motif within this block is essential for the G-actin binding and for actin polymerization. Block B is required for F-actin binding and subcellular location, and Block C for tetramerization.; DOMAI...
nan
nan
P51959
MIEVLTTTDSQKLLHQLNALLEQESRCQPKVCGLRLIESAHDNGLRMTARLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSIEEERNVPLATDLIRISQYRFTVSDLMRMEKIVLEKVCWKVKATTAFQFLQLYYSLLQENLPLERRNSINFERLEAQLKACHCRIIFSKAKPSVLALSIIALEIQAQKCVELTEGIECLQKHSKINGRDLTFWQELVSKCLTEYSSNKCSKPNVQKLKWIVSGRTARQLKHSYYRITHLPTIPEMVP
295
34,073.5589
9.062015
0.077966
42.849525
-0.126102
0.369492
0.19661
0.4
15
0.051
11
0.037
9
0.031
22
0.075
13
0.044
8
0.027
7
0.024
17
0.058
23
0.078
43
0.146
6
0.02
10
0.034
9
0.031
17
0.058
18
0.061
22
0.075
17
0.058
18
0.061
3
0.01
7
0.024
295
34,072.67
9.576
0.000281
P51959
CCNG1_HUMAN
Cyclin-G1 (Cyclin-G)
Homo sapiens (Human)
295
34,074
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10196184}. Note=DNA replication foci after DNA damage.
cell division [GO:0051301]; G1/S transition of mitotic cell cycle [GO:0000082]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]
cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10196184}. Note=DNA replication foci after DNA damage.
FUNCTION: May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity). {ECO:0000250}.
nan
INDUCTION: Activated in breast and prostate cancer cells. Activated by actinomycin-D induced DNA damage.
nan
P50416
MAEAHQAVAFQFTVTPDGIDLRLSHEALRQIYLSGLHSWKKKFIRFKNGIITGVYPASPSSWLIVVVGVMTTMYAKIDPSLGIIAKINRTLETANCMSSQTKNVVSGVLFGTGLWVALIVTMRYSLKVLLSYHGWMFTEHGKMSRATKIWMGMVKIFSGRKPMLYSFQTSLPRLPVPAVKDTVNRYLQSVRPLMKEEDFKRMTALAQDFAVGLGPRLQWYLKLKSWWATNYVSDWWEEYIYLRGRGPLMVNSNYYAMDLLYILPTHIQAARAGNAIHAILLYRRKLDREEIKPIRLLGSTIPLCSAQWERMFNTSRIPGE...
773
88,366.6172
8.847077
0.112549
37.898706
-0.26119
0.311772
0.26132
0.379043
52
0.067
12
0.016
38
0.049
43
0.056
36
0.047
49
0.063
23
0.03
39
0.05
44
0.057
75
0.097
27
0.035
24
0.031
34
0.044
29
0.038
48
0.062
57
0.074
44
0.057
48
0.062
18
0.023
33
0.043
773
88,365.9
11.046
0.000125
P50416
CPT1A_HUMAN
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1-L) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, liver isoform) (CPT I) (CPTI-L) (Carnitine palmitoyltransferase 1A) (Succinyltransferase CPT1A) (EC 2.3.1.-)
Homo sapiens (Human)
773
88,368
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:11350182, ECO:0000269|PubMed:14517221}; Multi-pass membrane protein {ECO:0000255}.
aflatoxin metabolic process [GO:0046222]; carnitine metabolic process [GO:0009437]; carnitine shuttle [GO:0006853]; cellular response to fatty acid [GO:0071398]; eating behavior [GO:0042755]; epithelial cell differentiation [GO:0030855]; fatty acid beta-oxidation [GO:0006635]; fatty acid metabolic process [GO:0006631];...
carnitine O-palmitoyltransferase activity [GO:0004095]; identical protein binding [GO:0042802]; protein-macromolecule adaptor activity [GO:0030674]
2.3.1.-; 2.3.1.21
nan
CATALYTIC ACTIVITY: Reaction=(R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA; Xref=Rhea:RHEA:12661, ChEBI:CHEBI:16347, ChEBI:CHEBI:17490, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379; EC=2.3.1.21; Evidence={ECO:0000269|PubMed:11350182, ECO:0000269|PubMed:14517221, ECO:0000269|PubMed:16651524, ECO:0000269|...
PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:11350182, ECO:0000269|PubMed:14517221}; Multi-pass membrane protein {ECO:0000255}.
FUNCTION: Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (PubMed:11350182, PubMed:14517221, PubMed:16651524, PubMed:9691089). Also possesses...
DOMAIN: A conformation change in the N-terminal region spanning the first 42 residues plays an important role in the regulation of enzyme activity by malonyl-CoA. {ECO:0000269|PubMed:21990363}.
INDUCTION: Up-regulated by fatty acids. {ECO:0000269|PubMed:16271724}.
nan
P50226
MELIQDISRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKVPGIPSGMETLKNTPAPRLLKTHLPLALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVYPHPGTWESFLEKFMAGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEETVDLMVEHTSFKEMKKNPMTNYTTVRREFMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAKKMAGCSLSFRSEL
295
34,309.3163
7.750588
0.125424
37.733288
-0.355593
0.345763
0.244068
0.383051
16
0.054
2
0.007
13
0.044
22
0.075
16
0.054
14
0.047
9
0.031
11
0.037
22
0.075
28
0.095
14
0.047
6
0.02
21
0.071
11
0.037
14
0.047
18
0.061
17
0.058
20
0.068
6
0.02
15
0.051
295
34,308.44
2.031
0.000059
P50226
ST1A2_HUMAN
Sulfotransferase 1A2 (ST1A2) (EC 2.8.2.1) (Aryl sulfotransferase 2) (Phenol sulfotransferase 2) (Phenol-sulfating phenol sulfotransferase 2) (P-PST 2)
Homo sapiens (Human)
295
34,310
SUBCELLULAR LOCATION: Cytoplasm.
3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; amine biosynthetic process [GO:0009309]; catecholamine metabolic process [GO:0006584]; ethanol catabolic process [GO:0006068]; phenol-containing compound metabolic process [GO:0018958]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923]; ...
aryl sulfotransferase activity [GO:0004062]; flavonol 3-sulfotransferase activity [GO:0047894]; sulfotransferase activity [GO:0008146]
2.8.2.1
nan
CATALYTIC ACTIVITY: Reaction=a phenol + 3'-phosphoadenylyl sulfate = an aryl sulfate + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:12164, ChEBI:CHEBI:15378, ChEBI:CHEBI:33853, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:140317; EC=2.8.2.1; Evidence={ECO:0000269|PubMed:20417180};
nan
SUBCELLULAR LOCATION: Cytoplasm.
FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxya...
nan
nan
nan
P50406
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIY...
440
46,953.8063
9.266895
0.075
45.968636
0.432955
0.338636
0.309091
0.388636
51
0.116
14
0.032
13
0.03
8
0.018
19
0.043
30
0.068
5
0.011
15
0.034
6
0.014
74
0.168
10
0.023
12
0.027
44
0.1
12
0.027
27
0.061
37
0.084
24
0.055
25
0.057
8
0.018
6
0.014
440
46,952.97
11.035
0.000235
P50406
5HT6R_HUMAN
5-hydroxytryptamine receptor 6 (5-HT-6) (5-HT6) (Serotonin receptor 6)
Homo sapiens (Human)
440
46,954
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:37327704}; Multi-pass membrane protein {ECO:0000269|PubMed:35714614, ECO:0000269|PubMed:36989299, ECO:0000269|PubMed:37327704}.
adenylate cyclase-activating serotonin receptor signaling pathway [GO:0007192]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cerebral cortex cell migration [GO:0021795]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway, coupled to cycli...
G protein-coupled serotonin receptor activity [GO:0004993]; histamine receptor activity [GO:0004969]; neurotransmitter receptor activity [GO:0030594]; serotonin receptor activity [GO:0099589]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:37327704}; Multi-pass membrane protein {ECO:0000269|PubMed:35714614, ECO:0000269|PubMed:36989299, ECO:0000269|PubMed:37327704}.
FUNCTION: G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:35714614, PubMed:36989299, PubMed:37327704, PubMed:8522988). Also has a high affinity for tricyclic psychotropic drugs (By similarity). Ligand binding causes...
DOMAIN: Specificity for G(s) G alpha proteins is determined by the length of transmembrane regions 5 and 6 (TM5 and TM6). {ECO:0000250|UniProtKB:Q13639}.
nan
nan
P50748
MWNDIELLTNDDTGSGYLSVGSRKEHGTALYQVDLLVKISSEKASLNPKIQACSLSDGFIIVADQSVILLDSICRSLQLHLVFDTEVDVVGLCQEGKFLLVGERSGNLHLIHVTSKQTLLTNAFVQKANDENRRTYQNLVIEKDGSNEGTYYMLLLTYSGFFCITNLQLLKIQQAIENVDFSTAKKLQGQIKSSFISTENYHTLGCLSLVAGDLASEVPVIIGGTGNCAFSKWEPDSSKKGMTVKNLIDAEIIKGAKKFQLIDNLLFVLDTDNVLSLWDIYTLTPVWNWPSLHVEEFLLTTEADSPSSVTWQGITNLKLI...
2,209
250,745.595
5.667382
0.080579
41.948221
-0.058533
0.388411
0.238569
0.401086
143
0.065
46
0.021
110
0.05
172
0.078
83
0.038
77
0.035
53
0.024
140
0.063
163
0.074
330
0.149
50
0.023
88
0.04
73
0.033
98
0.044
71
0.032
179
0.081
112
0.051
126
0.057
33
0.015
62
0.028
2,209
250,745.42
-51.969
-0.000207
P50748
KNTC1_HUMAN
Kinetochore-associated protein 1 (Rough deal homolog) (HsROD) (Rod) (hRod)
Homo sapiens (Human)
2,209
250,749
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Dynamic pattern of localization during the cell cycle. At interphase, uniformly distributed throughout the cytoplasm and nucleus. By prophase and until late stages of prometaphase, a fraction of the tot...
cell division [GO:0051301]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to kinetochore involved in kinetochore assembly [GO:1903394]; protein-containing complex assembly [GO:0065003]; regulation of attachment of spindle microtubules...
small GTPase binding [GO:0031267]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Dynamic pattern of localization during the cell cycle. At interphase, uniformly distributed throughout the cytoplasm and nucleus. By prophase and until late stages of prometaphase, a fraction of the tot...
FUNCTION: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores (PubMed:11146660, PubMed:11590237, PubMed:15824131). Its function related to the spindle assembly machinery is propos...
nan
nan
nan
P50151
MSSGASASALQRLVEQLKLEAGVERIKVSQAAAELQQYCMQNACKDALLVGVPAGSNPFREPRSCALL
68
7,205.2603
7.708868
0.029412
59.832353
0.023529
0.441176
0.25
0.25
11
0.162
3
0.044
1
0.015
5
0.074
1
0.015
4
0.059
0
0
1
0.015
3
0.044
9
0.132
2
0.029
2
0.029
3
0.044
6
0.088
4
0.059
7
0.103
0
0
5
0.074
0
0
1
0.015
68
7,204.3
1.527
0.000212
P50151
GBG10_HUMAN
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
Homo sapiens (Human)
68
7,205
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
G protein-coupled receptor signaling pathway [GO:0007186]; signal transduction [GO:0007165]
G-protein beta-subunit binding [GO:0031681]; GTPase activity [GO:0003924]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but no...
nan
nan
nan
P50461
MPNWGGGAKCGACEKTVYHAEEIQCNGRSFHKTCFHCMACRKALDSTTVAAHESEIYCKVCYGRRYGPKGIGYGQGAGCLSTDTGEHLGLQFQQSPKPARSVTTSNPSKFTAKFGESEKCPRCGKSVYAAEKVMGGGKPWHKTCFRCAICGKSLESTNVTDKDGELYCKVCYAKNFGPTGIGFGGLTQQVEKKE
194
20,968.7146
8.890464
0.092784
38.717526
-0.540206
0.293814
0.283505
0.273196
14
0.072
16
0.082
4
0.021
13
0.067
8
0.041
26
0.134
6
0.031
5
0.026
20
0.103
7
0.036
3
0.015
5
0.026
8
0.041
7
0.036
7
0.036
12
0.062
14
0.072
9
0.046
2
0.01
8
0.041
194
20,967.81
8.759
0.000418
P50461
CSRP3_HUMAN
Cysteine and glycine-rich protein 3 (Cardiac LIM protein) (Cysteine-rich protein 3) (CRP3) (LIM domain protein, cardiac) (Muscle LIM protein)
Homo sapiens (Human)
194
20,969
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P50463}. Cytoplasm {ECO:0000269|PubMed:18505755}. Cytoplasm, cytoskeleton {ECO:0000305}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:24860983}. Cytoplasm, myofibril, sarcomere {ECO:0000269|PubMed:24934443}. Note=Nucleocytoplasmic shuttling protein. Ma...
cardiac muscle contraction [GO:0060048]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue development [GO:0048738]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; glucose homeostasis [GO:0042593]; inflammatory response [GO:0006954]; insulin receptor signaling pathway [G...
actin binding [GO:0003779]; actinin binding [GO:0042805]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; structural constituent of muscle [GO:0008307]; telethonin binding [GO:0031433]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P50463}. Cytoplasm {ECO:0000269|PubMed:18505755}. Cytoplasm, cytoskeleton {ECO:0000305}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:24860983}. Cytoplasm, myofibril, sarcomere {ECO:0000269|PubMed:24934443}. Note=Nucleocytoplasmic shuttling protein. Ma...
FUNCTION: Positive regulator of myogenesis. Acts as a cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis ...
DOMAIN: LIM zinc-binding domain 1 is required for self-association. LIM zinc-binding domain 1 and LIM zinc-binding domain 2 both are required for optimal actin-bundling activity (PubMed:24934443). LIM zinc-binding domain 1 mediates binding to MYOD1. LIM zinc-binding domain 2 mediates binding to SPTB (By similarity). {E...
nan
nan
P49901
MCDQTKHSKCCPAKGNQCCPPQQNQCCQSKGNQCCPPKQNQCCQPKGSQCCPPKHNHCCQPKPPCCIQARCCGLETKPEVSPLNMESEPNSPQTQDKGCQTQQQPHSPQNESRPSK
116
12,767.4398
8.489149
0
60.309483
-1.330172
0.189655
0.362069
0.068966
2
0.017
20
0.172
2
0.017
5
0.043
0
0
5
0.043
4
0.034
1
0.009
11
0.095
2
0.017
2
0.017
8
0.069
18
0.155
20
0.172
2
0.017
9
0.078
4
0.034
1
0.009
0
0
0
0
116
12,766.52
4.075
0.000319
P49901
MCSP_HUMAN
Sperm mitochondrial-associated cysteine-rich protein
Homo sapiens (Human)
116
12,767
SUBCELLULAR LOCATION: Cytoplasm. Mitochondrion membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Becomes associated with the spermatid mitochondrion capsule at step 16 of spermatogenesis. {ECO:0000250}.
flagellated sperm motility [GO:0030317]; penetration of zona pellucida [GO:0007341]
nan
nan
nan
nan
nan
SUBCELLULAR LOCATION: Cytoplasm. Mitochondrion membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Becomes associated with the spermatid mitochondrion capsule at step 16 of spermatogenesis. {ECO:0000250}.
FUNCTION: Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity). {ECO:0000250}.
nan
nan
nan
P49863
MTKFSSFSLFFLIVGAYMTHVCFNMEIIGGKEVSPHSRPFMASIQYGGHHVCGGVLIDPQWVLTAAHCQYRFTKGQSPTVVLGAHSLSKNEASKQTLEIKKFIPFSRVTSDPQSNDIMLVKLQTAAKLNKHVKMLHIRSKTSLRSGTKCKVTGWGATDPDSLRPSDTLREVTVTVLSRKLCNSQSYYNGDPFITKDMVCAGDAKGQKDSCKGDSGGPLICKGVFHAIVSGGHECGVATKPGIYTLLTKKYQTWIKSNLVPPHTN
264
28,882.1216
9.481897
0.079545
37.726136
-0.192424
0.265152
0.30303
0.363636
13
0.049
9
0.034
11
0.042
6
0.023
11
0.042
23
0.087
11
0.042
14
0.053
24
0.091
20
0.076
7
0.027
8
0.03
13
0.049
10
0.038
8
0.03
25
0.095
21
0.08
20
0.076
3
0.011
7
0.027
264
28,881.25
15.043
0.000521
P49863
GRAK_HUMAN
Granzyme K (EC 3.4.21.-) (Fragmentin-3) (Granzyme-3) (NK-tryptase-2) (NK-Tryp-2)
Homo sapiens (Human)
264
28,882
SUBCELLULAR LOCATION: Secreted. Cytoplasmic granule.
granzyme-mediated programmed cell death signaling pathway [GO:0140507]; protein maturation [GO:0051604]; proteolysis [GO:0006508]
serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]
3.4.21.-
nan
nan
nan
SUBCELLULAR LOCATION: Secreted. Cytoplasmic granule.
nan
nan
nan
nan
P50213
MAGPAWISKVSRLLGAFHNPKQVTRGFTGGVQTVTLIPGDGIGPEISAAVMKIFDAAKAPIQWEERNVTAIQGPGGKWMIPSEAKESMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIRENTEGEYSGIEHVIVDGVVQSIKLITEGASKRIAEFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVAESCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGL...
366
39,591.2801
6.464662
0.062842
41.237432
-0.056284
0.330601
0.300546
0.338798
34
0.093
8
0.022
21
0.057
20
0.055
13
0.036
34
0.093
8
0.022
27
0.074
24
0.066
28
0.077
15
0.041
18
0.049
17
0.046
8
0.022
15
0.041
20
0.055
20
0.055
26
0.071
3
0.008
7
0.019
366
39,590.43
-1.919
-0.000048
P50213
IDH3A_HUMAN
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit alpha) (NAD(+)-specific ICDH subunit alpha)
Homo sapiens (Human)
366
39,592
SUBCELLULAR LOCATION: Mitochondrion.
carbohydrate metabolic process [GO:0005975]; isocitrate metabolic process [GO:0006102]; tricarboxylic acid cycle [GO:0006099]
isocitrate dehydrogenase (NAD+) activity [GO:0004449]; magnesium ion binding [GO:0000287]; NAD binding [GO:0051287]
1.1.1.41
nan
CATALYTIC ACTIVITY: Reaction=D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH; Xref=Rhea:RHEA:23632, ChEBI:CHEBI:15562, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.41; Evidence={ECO:0000269|PubMed:28098230, ECO:0000269|PubMed:28139779}; PhysiologicalDirection=left-to-ri...
nan
SUBCELLULAR LOCATION: Mitochondrion.
FUNCTION: Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full ...
nan
nan
nan
P50895
MEPPDAPAQARGAPRLLLLAVLLAAHPDAQAEVRLSVPPLVEVMRGKSVILDCTPTGTHDHYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRGRSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEG...
628
67,404.0305
5.53273
0.05414
45.363869
-0.327707
0.299363
0.335987
0.321656
50
0.08
14
0.022
30
0.048
43
0.068
12
0.019
61
0.097
16
0.025
8
0.013
15
0.024
69
0.11
11
0.018
16
0.025
47
0.075
24
0.038
42
0.067
57
0.091
41
0.065
50
0.08
8
0.013
14
0.022
628
67,403.26
-16.503
-0.000245
P50895
BCAM_HUMAN
Basal cell adhesion molecule (Auberger B antigen) (B-CAM cell surface glycoprotein) (F8/G253 antigen) (Lutheran antigen) (Lutheran blood group glycoprotein) (CD antigen CD239)
Homo sapiens (Human)
628
67,405
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15238148, ECO:0000269|PubMed:31413112}; Single-pass type I membrane protein.
angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; signal transduction [GO:0007165]
laminin binding [GO:0043236]; laminin receptor activity [GO:0005055]; transmembrane signaling receptor activity [GO:0004888]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15238148, ECO:0000269|PubMed:31413112}; Single-pass type I membrane protein.
FUNCTION: Transmembrane glycoprotein that functions as both a receptor and an adhesion molecule playing a crucial role in cell adhesion, motility, migration and invasion (PubMed:9616226, PubMed:31413112). Extracellular domain enables binding to extracellular matrix proteins, such as laminin, integrin and other ligands ...
nan
nan
nan
P50458
MLFHSLSGPEVHGVIDEMDRRAKSEAPAISSAIDRGDTETTMPSISSDRAALCAGCGGKISDRYYLLAVDKQWHMRCLKCCECKLNLESELTCFSKDGSIYCKEDYYRRFSVQRCARCHLGISASEMVMRARDLVYHLNCFTCTTCNKMLTTGDHFGMKDSLVYCRLHFEALLQGEYPAHFNHADVAAAAAAAAAAKSAGLGAAGANPLGLPYYNGVGTVQKGRPRKRKSPGPGADLAAYNAALSCNENDAEHLDRDQPYPSSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAK...
406
44,372.7517
8.806462
0.066502
38.353448
-0.457389
0.327586
0.300493
0.300493
43
0.106
15
0.037
22
0.054
17
0.042
12
0.03
26
0.064
15
0.037
8
0.02
23
0.057
40
0.099
10
0.025
17
0.042
21
0.052
14
0.034
25
0.062
36
0.089
31
0.076
16
0.039
2
0.005
13
0.032
406
44,371.91
8.283
0.000187
P50458
LHX2_HUMAN
LIM/homeobox protein Lhx2 (Homeobox protein LH-2) (LIM homeobox protein 2)
Homo sapiens (Human)
406
44,373
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
axon extension [GO:0048675]; axon guidance [GO:0007411]; cerebral cortex development [GO:0021987]; dorsal/ventral pattern formation [GO:0009953]; hair follicle development [GO:0001942]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; mesoderm development [GO:0007498]; negative regulation of gene expr...
chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; R...
nan
nan
nan
nan
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
FUNCTION: Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity). {ECO:0000250}.
DOMAIN: LIM domains are necessary for transcription activation. {ECO:0000250}.
nan
nan
P55854
MSEEKPKEGVKTENDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGVPESSLAGHSF
103
11,636.9137
5.320607
0.058252
44.366019
-0.828155
0.31068
0.291262
0.281553
4
0.039
1
0.01
7
0.068
10
0.097
5
0.049
8
0.078
3
0.029
5
0.049
8
0.078
6
0.058
4
0.039
3
0.029
5
0.049
9
0.087
5
0.049
7
0.068
6
0.058
6
0.058
0
0
1
0.01
103
11,635.97
-3.038
-0.000261
P55854
SUMO3_HUMAN
Small ubiquitin-related modifier 3 (SUMO-3) (SMT3 homolog 1) (SUMO-2) (Ubiquitin-like protein SMT3A) (Smt3A)
Homo sapiens (Human)
103
11,637
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Nucleus, PML body {ECO:0000250}.
negative regulation of DNA binding [GO:0043392]; protein sumoylation [GO:0016925]; regulation of protein localization to nucleus [GO:1900180]
protein tag activity [GO:0031386]; ubiquitin-like protein ligase binding [GO:0044389]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Nucleus, PML body {ECO:0000250}.
FUNCTION: Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuc...
nan
nan
nan
P49639
MDNARMNSFLEYPILSSGDSGTCSARAYPSDHRITTFQSCAVSANSCGGDDRFLVGRGVQIGSPHHHHHHHHRHPQPATYQTSGNLGVSYSHSSCGPSYGSQNFSAPYSPYALNQEADVSGGYPQCAPAVYSGNLSSPMVQHHHHHQGYAGGAVGSPQYIHHSYGQEHQSLALATYNNSLSPLHASHQEACRSPASETSSPAQTFDWMKVKRNPPKTGKVGEYGYLGQPNAVRTNFTTKQLTELEKEFHFNKYLTRARRVEIAASLQLNETQVKIWFQNRRMKQKKREKEGLLPISPATPPGNDEKAEESSEKSSSSPCV...
335
36,659.8293
8.396379
0.080597
59.381493
-0.826269
0.238806
0.364179
0.259701
25
0.075
7
0.021
9
0.027
17
0.051
9
0.027
26
0.078
23
0.069
7
0.021
14
0.042
19
0.057
5
0.015
16
0.048
25
0.075
20
0.06
15
0.045
46
0.137
20
0.06
14
0.042
2
0.006
16
0.048
335
36,658.99
3.846
0.000105
P49639
HXA1_HUMAN
Homeobox protein Hox-A1 (Homeobox protein Hox-1F)
Homo sapiens (Human)
335
36,660
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P09022}.
abducens nerve formation [GO:0021599]; anatomical structure morphogenesis [GO:0009653]; artery development [GO:0060840]; artery morphogenesis [GO:0048844]; cochlea development [GO:0090102]; cochlea morphogenesis [GO:0090103]; cognition [GO:0050890]; embryonic neurocranium morphogenesis [GO:0048702]; inner ear developme...
DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA bin...
nan
nan
nan
nan
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P09022}.
FUNCTION: Sequence-specific transcription factor (By similarity). Regulates multiple developmental processes including brainstem, inner and outer ear, abducens nerve and cardiovascular development and morphogenesis as well as cognition and behavior (PubMed:16155570). Also part of a developmental regulatory system that ...
nan
nan
nan
P49790
MASGAGGVGGGGGGKIRTRRCHQGPIKPYQQGRQQHQGILSRVTESVKNIVPGWLQRYFNKNEDVCSCSTDTSEVPRWPENKEDHLVYADEESSNITDGRITPEPAVSNTEEPSTTSTASNYPDVLTRPSLHRSHLNFSMLESPALHCQPSTSSAFPIGSSGFSLVKEIKDSTSQHDDDNISTTSGFSSRASDKDITVSKNTSLPPLWSPEAERSHSLSQHTATSSKKPAFNLSAFGTLSPSLGNSSILKTSQLGDSPFYPGKTTYGGAAAAVRQSKLRNTPYQAPVRRQMKAKQLSAQSYGVTSSTARRILQSLEKMSS...
1,475
153,936.5707
8.97221
0.073898
60.835058
-0.469085
0.238644
0.421017
0.293559
99
0.067
28
0.019
42
0.028
72
0.049
89
0.06
127
0.086
11
0.007
45
0.031
97
0.066
69
0.047
15
0.01
68
0.046
117
0.079
58
0.039
41
0.028
267
0.181
133
0.09
77
0.052
7
0.005
13
0.009
1,475
153,936.21
21.109
0.000137
P49790
NU153_HUMAN
Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153)
Homo sapiens (Human)
1,475
153,938
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:38129135}. Nucleus membrane. Nucleus, nuclear pore complex. Note=Tightly associated with the nuclear membrane and lamina (By similarity). Localized to the nucleoplasmic side of the nuclear pore complex (NPC) core structure, forming a fibrous structure called the nuclear...
amyloid fibril formation [GO:1990000]; mRNA transport [GO:0051028]; negative regulation of RNA export from nucleus [GO:0046832]; nuclear pore complex assembly [GO:0051292]; nucleocytoplasmic transport [GO:0006913]; protein import into nucleus [GO:0006606]; RNA export from nucleus [GO:0006405]; symbiont entry into host ...
DNA binding [GO:0003677]; identical protein binding [GO:0042802]; molecular condensate scaffold activity [GO:0140693]; nuclear localization sequence binding [GO:0008139]; protein-membrane adaptor activity [GO:0043495]; structural constituent of nuclear pore [GO:0017056]; zinc ion binding [GO:0008270]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:38129135}. Nucleus membrane. Nucleus, nuclear pore complex. Note=Tightly associated with the nuclear membrane and lamina (By similarity). Localized to the nucleoplasmic side of the nuclear pore complex (NPC) core structure, forming a fibrous structure called the nuclear...
FUNCTION: Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced...
DOMAIN: Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conserva...
nan
nan
P41091
MAGGEAGVTLGQPHLSRQDLTTLDVTKLTPLSHEVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVS...
472
51,108.897
8.657475
0.044492
36.703602
-0.013559
0.317797
0.279661
0.372881
32
0.068
10
0.021
23
0.049
29
0.061
11
0.023
43
0.091
11
0.023
40
0.085
36
0.076
45
0.095
8
0.017
14
0.03
25
0.053
16
0.034
22
0.047
27
0.057
26
0.055
44
0.093
2
0.004
8
0.017
472
51,108.09
5.895
0.000115
P41091
IF2G_HUMAN
Eukaryotic translation initiation factor 2 subunit 3 (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma X) (eIF2-gamma X) (eIF2gX)
Homo sapiens (Human)
472
51,109
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q09130}.
cytoplasmic translational initiation [GO:0002183]; formation of translation preinitiation complex [GO:0001731]; translational initiation [GO:0006413]
cadherin binding [GO:0045296]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; methionyl-initiator methionine tRNA binding [GO:1990856]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]
3.6.5.3
nan
CATALYTIC ACTIVITY: Reaction=GTP + H2O = GDP + phosphate + H(+); Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.3; Evidence={ECO:0000250|UniProtKB:P32481};
nan
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q09130}.
FUNCTION: Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC) (By similarity). Junction of th...
nan
nan
nan
P49641
MKLKKQVTVCGAAIFCVAVFSLYLMLDRVQHDPTRHQNGGNFPRSQISVLQNRIEQLEQLLEENHEIISHIKDSVLELTANAEGPPAMLPYYTVNGSWVVPPEPRPSFFSISPQDCQFALGGRGQKPELQMLTVSEELPFDNVDGGVWRQGFDISYDPHDWDAEDLQVFVVPHSHNDPGWIKTFDKYYTEQTQHILNSMVSKLQEDPRRRFLWAEVSFFAKWWDNINVQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALIDQLIEGHQWLERNLGATPRSGWAVDPFGYSSTMPYLLRRANLTSMLIQRVHYAIKK...
1,150
130,537.003
6.354224
0.104348
48.58107
-0.264435
0.288696
0.288696
0.38
75
0.065
12
0.01
71
0.062
57
0.05
59
0.051
69
0.06
41
0.036
38
0.033
38
0.033
142
0.123
20
0.017
37
0.032
72
0.063
61
0.053
77
0.067
83
0.072
53
0.046
84
0.073
17
0.015
44
0.038
1,150
130,536.43
-12.206
-0.000094
P49641
MA2A2_HUMAN
Alpha-mannosidase 2x (EC 3.2.1.114) (Alpha-mannosidase IIx) (Man IIx) (Mannosidase alpha class 2A member 2) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)
Homo sapiens (Human)
1,150
130,539
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
mannose metabolic process [GO:0006013]; N-glycan processing [GO:0006491]; protein glycosylation [GO:0006486]
alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; hydrolase activity, hydrolyzing N-glycosyl compounds [GO:0016799]; mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity [GO:0004572]; metal ion binding [GO:0046872]
3.2.1.114
nan
CATALYTIC ACTIVITY: Reaction=N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 2 H2O = 2 alpha-D-mannopyranose + an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-...
PATHWAY: Protein modification; protein glycosylation.
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
FUNCTION: Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.
nan
nan
nan
P49619
MGEERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDPHEPISYDVFKLFMRAYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADTNIQNADNATKADEACAPDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDKLEFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGFVSLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIPG...
791
89,123.0153
6.35951
0.079646
41.527054
-0.448293
0.312263
0.299621
0.323641
39
0.049
28
0.035
48
0.061
54
0.068
28
0.035
59
0.075
25
0.032
34
0.043
53
0.067
73
0.092
28
0.035
31
0.039
46
0.058
30
0.038
41
0.052
53
0.067
40
0.051
46
0.058
12
0.015
23
0.029
791
89,122.32
-10.31
-0.000116
P49619
DGKG_HUMAN
Diacylglycerol kinase gamma (DAG kinase gamma) (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma)
Homo sapiens (Human)
791
89,124
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:8034597}. Cytoplasm, cytosol {ECO:0000269|PubMed:8034597}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P49620}.
diacylglycerol metabolic process [GO:0046339]; glycerolipid metabolic process [GO:0046486]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; negative regulation of phospholipase C/protein kinase C signal transduction [GO:0160195]; phosphatidic acid biosynthetic process [GO:0006654]; p...
ATP binding [GO:0005524]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; calcium ion binding [GO:0005509]; lipid binding [GO:0008289]; zinc ion binding [GO:0008270]
2.7.1.107
nan
CATALYTIC ACTIVITY: Reaction=a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:10272, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:30616, ChEBI:CHEBI:58608, ChEBI:CHEBI:456216; EC=2.7.1.107; Evidence={ECO:0000269|PubMed:8034597}; PhysiologicalDirection=left-to-right;...
PATHWAY: Lipid metabolism; glycerolipid metabolism. {ECO:0000305|PubMed:8034597}.
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:8034597}. Cytoplasm, cytosol {ECO:0000269|PubMed:8034597}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P49620}.
FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:8034597). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targe...
nan
nan
nan
P39023
MSHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDPSKPVHLTAFLGYKAGMTHIVREVDRPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTFKTVFAEHISDECKRRFYKNWHKSKKKAFTKYCKKWQDEDGKKQLEKDFSSMKKYCQVIRVIAHTQMRLLPLRQKKAHLMEIQVNGGTVAEKLDWARERLEQQVPVNQVFGQDEMIDVIGVTKGKGYKGVTSRWHTKKLPRKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGQGYLIKDGKLIKNNASTDYDLSDKSINPLGGF...
403
46,108.3393
10.193499
0.081886
30.141712
-0.646898
0.332506
0.233251
0.337469
21
0.052
5
0.012
18
0.045
21
0.052
17
0.042
33
0.082
16
0.04
19
0.047
56
0.139
26
0.065
10
0.025
9
0.022
15
0.037
14
0.035
30
0.074
19
0.047
23
0.057
35
0.087
5
0.012
11
0.027
403
46,107.5
47.852
0.001038
P39023
RL3_HUMAN
Large ribosomal subunit protein uL3 (60S ribosomal protein L3) (HIV-1 TAR RNA-binding protein B) (TARBP-B)
Homo sapiens (Human)
403
46,109
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16963496}. Cytoplasm {ECO:0000269|PubMed:16963496, ECO:0000269|PubMed:23636399}.
cellular response to interleukin-4 [GO:0071353]; cytoplasmic translation [GO:0002181]; translation [GO:0006412]
RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16963496}. Cytoplasm {ECO:0000269|PubMed:16963496, ECO:0000269|PubMed:23636399}.
FUNCTION: Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547, PubMed:35674491). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|...
nan
nan
nan
P21757
MEQWDHFHNQQEDTDSCSESVKFDARSMTALLPPNPKNSPSLQEKLKSFKAALIALYLLVFAVLIPLIGIVAAQLLKWETKNCSVSSTNANDITQSLTGKGNDSEEEMRFQEVFMEHMSNMEKRIQHILDMEANLMDTEHFQNFSMTTDQRFNDILLQLSTLFSSVQGHGNAIDEISKSLISLNTTLLDLQLNIENLNGKIQENTFKQQEEISKLEERVYNVSAEIMAMKEEQVHLEQEIKGEVKVLNNITNDLRLKDWEHSQTLRNITLIQGPPGPPGEKGDRGPTGESGPRGFPGPIGPPGLKGDRGAIGFPGSRGLP...
451
49,761.5457
5.613555
0.062084
41.960532
-0.498004
0.299335
0.325942
0.317073
20
0.044
8
0.018
19
0.042
38
0.084
17
0.038
46
0.102
13
0.029
26
0.058
25
0.055
41
0.091
11
0.024
25
0.055
23
0.051
26
0.058
20
0.044
34
0.075
25
0.055
23
0.051
7
0.016
4
0.009
451
49,760.73
-11.695
-0.000235
P21757
MSRE_HUMAN
Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II) (Scavenger receptor class A member 1) (CD antigen CD204)
Homo sapiens (Human)
451
49,762
SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
amyloid-beta clearance [GO:0097242]; cholesterol transport [GO:0030301]; establishment of localization in cell [GO:0051649]; lipoprotein transport [GO:0042953]; negative regulation of gene expression [GO:0010629]; phagocytosis, engulfment [GO:0006911]; plasma lipoprotein particle clearance [GO:0034381]; positive regula...
amyloid-beta binding [GO:0001540]; cargo receptor activity [GO:0038024]; low-density lipoprotein particle binding [GO:0030169]; scavenger receptor activity [GO:0005044]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
FUNCTION: Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL) (PubMed:2251254). Isoform ...
nan
nan
nan
P21796
MAVPPTYADLGKSARDVFTKGYGFGLIKLDLKTKSENGLEFTSSGSANTETTKVTGSLETKYRWTEYGLTFTEKWNTDNTLGTEITVEDQLARGLKLTFDSSFSPNTGKKNAKIKTGYKREHINLGCDMDFDIAGPSIRGALVLGYEGWLAGYQMNFETAKSRVTQSNFAVGYKTDEFQLHTNVNDGTEFGGSIYQKVNKKLETAVNLAWTAGNSNTRFGIAAKYQIDPDACFSAKVNNSSLIGLGYTQTLKPGIKLTLSALLDGKNVNAGGHKLGLGLEFQA
283
30,772.2045
8.61989
0.102473
17.475972
-0.410954
0.325088
0.314488
0.388693
21
0.074
2
0.007
14
0.049
15
0.053
14
0.049
32
0.113
3
0.011
11
0.039
25
0.088
28
0.099
3
0.011
19
0.067
6
0.021
8
0.028
7
0.025
18
0.064
30
0.106
12
0.042
4
0.014
11
0.039
283
30,771.33
3.783
0.000123
P21796
VDAC1_HUMAN
Non-selective voltage-gated ion channel VDAC1 (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) (Voltage-dependent anion-selective channel protein 1) (VDAC-1) (hVDAC1)
Homo sapiens (Human)
283
30,773
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:10661876, ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:31206022, ECO:0000269|PubMed:7539795}; Multi-pass membrane protein {ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:18832158, ECO:0000269|PubMed:27641616}. Cell membrane {ECO:0000269|PubMed:2...
apoptotic process [GO:0006915]; behavioral fear response [GO:0001662]; calcium import into the mitochondrion [GO:0036444]; epithelial cell differentiation [GO:0030855]; learning [GO:0007612]; lipid transport [GO:0006869]; mitochondrial transmembrane transport [GO:1990542]; monoatomic anion transport [GO:0006820]; negat...
ATP binding [GO:0005524]; ceramide binding [GO:0097001]; cholesterol binding [GO:0015485]; identical protein binding [GO:0042802]; oxysterol binding [GO:0008142]; phosphatidylcholine binding [GO:0031210]; porin activity [GO:0015288]; protein kinase binding [GO:0019901]; transmembrane transporter binding [GO:0044325]; v...
nan
nan
CATALYTIC ACTIVITY: Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823, ChEBI:CHEBI:17996; Evidence={ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:8420959, ECO:0000305|PubMed:11845315}; CATALYTIC ACTIVITY: Reaction=K(+)(in) = K(+)(out); Xref=Rhea:RHEA:29463, ChEBI:CHEBI:29103; Evidence={ECO:0000269|PubMed:18...
nan
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:10661876, ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:31206022, ECO:0000269|PubMed:7539795}; Multi-pass membrane protein {ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:18832158, ECO:0000269|PubMed:27641616}. Cell membrane {ECO:0000269|PubMed:2...
FUNCTION: Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:30061676, PubMed:8420959). The channel at the outer mitochondrial membrane allows diffusion of small...
DOMAIN: Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands (PubMed:18755977, PubMed:18832158). The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity (PubMed:18755977, PubMed:18832158). {ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:1883215...
nan
nan
P21728
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFG...
446
49,292.8399
8.635814
0.103139
37.00361
0.334529
0.280269
0.273543
0.421525
39
0.087
16
0.036
15
0.034
17
0.038
27
0.061
18
0.04
7
0.016
38
0.085
19
0.043
41
0.092
9
0.02
21
0.047
21
0.047
9
0.02
20
0.045
47
0.105
29
0.065
34
0.076
9
0.02
10
0.022
446
49,292.01
5.801
0.000118
P21728
DRD1_HUMAN
D(1A) dopamine receptor (Dopamine D1 receptor)
Homo sapiens (Human)
446
49,293
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P18901}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P18901}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P18901}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P18901}. Cell projection, cilium membrane {ECO:0000269|PubMed:23936473}; Multi...
adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adult walking behavior [GO:0007628]; astrocyte development [GO:0014002];...
arrestin family protein binding [GO:1990763]; dopamine binding [GO:0035240]; dopamine neurotransmitter receptor activity [GO:0004952]; dopamine neurotransmitter receptor activity, coupled via Gs [GO:0001588]; G protein-coupled receptor activity [GO:0004930]; G-protein alpha-subunit binding [GO:0001965]; heterotrimeric ...
nan
nan
nan
nan
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P18901}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P18901}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P18901}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P18901}. Cell projection, cilium membrane {ECO:0000269|PubMed:23936473}; Multi...
FUNCTION: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
nan
nan
nan
P49458
MPQYQTWEEFSRAAEKLYLADPMKARVVLKYRHSDGNLCVKVTDDLVCLVYKTDQAQDVKKIEKFHSQLMRLMVAKEARNVTMETE
86
10,111.6386
7.763547
0.081395
24.339535
-0.513953
0.418605
0.162791
0.348837
7
0.081
2
0.023
6
0.07
7
0.081
2
0.023
1
0.012
2
0.023
1
0.012
9
0.105
8
0.093
5
0.058
2
0.023
2
0.023
5
0.058
5
0.058
3
0.035
5
0.058
9
0.105
1
0.012
4
0.047
86
10,110.68
1.758
0.000174
P49458
SRP09_HUMAN
Signal recognition particle 9 kDa protein (SRP9)
Homo sapiens (Human)
86
10,112
SUBCELLULAR LOCATION: Cytoplasm.
negative regulation of translational elongation [GO:0045900]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]
7S RNA binding [GO:0008312]; RNA binding [GO:0003723]; signal recognition particle binding [GO:0005047]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Cytoplasm.
FUNCTION: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arre...
nan
nan
nan
P49593
MSSGAPQKSSPMASGAEETPGFLDTLLQDFPALLNPEDPLPWKAPGTVLSQEEVEGELAELAMGFLGSRKAPPPLAAALAHEAVSQLLQTDLSEFRKLPREEEEEEEDDDEEEKAPVTLLDAQSLAQSFFNRLWEVAGQWQKQVPLAARASQRQWLVSIHAIRNTRRKMEDRHVSLPSFNQLFGLSDPVNRAYFAVFDGHGGVDAARYAAVHVHTNAARQPELPTDPEGALREAFRRTDQMFLRKAKRERLQSGTTGVCALIAGATLHVAWLGDSQVILVQQGQVVKLMEPHRPERQDEKARIEALGGFVSHMDCWRVNG...
454
49,830.2358
4.989577
0.059471
62.097577
-0.432599
0.356828
0.281938
0.295154
51
0.112
3
0.007
26
0.057
42
0.093
17
0.037
34
0.075
12
0.026
7
0.015
12
0.026
49
0.108
8
0.018
9
0.02
30
0.066
31
0.068
33
0.073
29
0.064
17
0.037
34
0.075
6
0.013
4
0.009
454
49,829.4
-21.956
-0.000441
P49593
PPM1F_HUMAN
Protein phosphatase 1F (EC 3.1.3.16) (Ca(2+)/calmodulin-dependent protein kinase phosphatase) (CaM-kinase phosphatase) (CaMKPase) (Partner of PIX 2) (Protein fem-2 homolog) (hFem-2)
Homo sapiens (Human)
454
49,831
nan
apoptotic process [GO:0006915]; cellular response to xenobiotic stimulus [GO:0071466]; intracellular signal transduction [GO:0035556]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein transport [G...
calmodulin-dependent protein phosphatase activity [GO:0033192]; metal ion binding [GO:0046872]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]
3.1.3.16
nan
CATALYTIC ACTIVITY: Reaction=O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; CATALYTIC ACTIVITY: Reaction=O-phospho-L-threonyl-[protein] + H2O = L-...
nan
nan
FUNCTION: Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis.
nan
nan
nan
P49450
MGPRRRSRKPEAPRRRSPSPTPTPGPSRRGPSLGASSHQHSRRRQGWLKEIRKLQKSTHLLIRKLPFSRLAREICVKFTRGVDFNWQAQALLALQEAAEAFLVHLFEDAYLLTLHAGRVTLFPKDVQLARRIRGLEEGLG
140
15,990.3647
11.713212
0.064286
79.027143
-0.622857
0.335714
0.25
0.307143
12
0.086
1
0.007
3
0.021
8
0.057
6
0.043
10
0.071
5
0.036
4
0.029
7
0.05
19
0.136
1
0.007
1
0.007
11
0.079
7
0.05
21
0.15
10
0.071
6
0.043
5
0.036
2
0.014
1
0.007
140
15,989.42
18.044
0.001128
P49450
CENPA_HUMAN
Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A)
Homo sapiens (Human)
140
15,991
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14667408, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:9024683}. Chromosome, centromere {ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:15282608, ECO:0000269|PubMed:15475964, ECO:0000269|PubMed:15702419, ECO:0000269|PubMed:17651496, ECO:0000269|PubMed:18072184, ECO:...
CENP-A containing chromatin assembly [GO:0034080]; establishment of mitotic spindle orientation [GO:0000132]; kinetochore assembly [GO:0051382]; mitotic cytokinesis [GO:0000281]; protein localization to CENP-A containing chromatin [GO:0061644]; protein localization to chromosome, centromeric region [GO:0071459]
chromatin binding [GO:0003682]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14667408, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:9024683}. Chromosome, centromere {ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:15282608, ECO:0000269|PubMed:15475964, ECO:0000269|PubMed:15702419, ECO:0000269|PubMed:17651496, ECO:0000269|PubMed:18072184, ECO:...
FUNCTION: Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:11756469, PubMed:14667408, PubMed:15282608, PubMed:15475964, PubMed:15702419, PubMed:17651496, PubMed:19114591, PubMed:20739937, PubMed:27499292, PubMed:7962047, PubMed:9024683). Replaces conventional H3 in the n...
DOMAIN: The CATD (CENPA targeting domain) region is responsible for the more compact structure of nucleosomes containing CENPA (PubMed:15282608). It is necessary and sufficient to mediate the localization into centromeres (PubMed:15282608, PubMed:7962047). {ECO:0000269|PubMed:15282608, ECO:0000269|PubMed:7962047}.
nan
nan
P49761
MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVAD...
490
58,587.7249
9.585627
0.106122
67.66002
-0.97898
0.283673
0.257143
0.302041
17
0.035
13
0.027
20
0.041
43
0.088
23
0.047
23
0.047
30
0.061
17
0.035
29
0.059
40
0.082
10
0.02
17
0.035
25
0.051
14
0.029
60
0.122
41
0.084
19
0.039
20
0.041
6
0.012
23
0.047
490
58,586.89
26.209
0.000447
P49761
CLK3_HUMAN
Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3)
Homo sapiens (Human)
490
58,588
SUBCELLULAR LOCATION: [Isoform 1]: Nucleus. Cytoplasm {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus speckle. Note=Co-localizes with serine- and arginine-rich (SR) proteins in the nuclear speckles.
protein phosphorylation [GO:0006468]; regulation of RNA splicing [GO:0043484]
ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]; RNA binding [GO:0003723]
2.7.12.1
nan
CATALYTIC ACTIVITY: Reaction=L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+); Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.1; CATALYTIC ACTIVITY: Reaction=L-threonyl-[protein]...
nan
SUBCELLULAR LOCATION: [Isoform 1]: Nucleus. Cytoplasm {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus speckle. Note=Co-localizes with serine- and arginine-rich (SR) proteins in the nuclear speckles.
FUNCTION: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistributio...
nan
nan
nan
P38571
MKMRFLGLVVCLVLWTLHSEGSGGKLTAVDPETNMNVSEIISYWGFPSEEYLVETEDGYILCLNRIPHGRKNHSDKGPKPVVFLQHGLLADSSNWVTNLANSSLGFILADAGFDVWMGNSRGNTWSRKHKTLSVSQDEFWAFSYDEMAKYDLPASINFILNKTGQEQVYYVGHSQGTTIGFIAFSQIPELAKRIKMFFALGPVASVAFCTSPMAKLGRLPDHLIKDLFGDKEFLPQSAFLKWLGTHVCTHVILKELCGNLCFLLCGFNERNLNMSRVDVYTTHSPAGTSVQNMLHWSQAVKFQKFQAFDWGSSAKNYFHY...
399
45,418.4706
6.423284
0.132832
38.144612
-0.108521
0.288221
0.295739
0.406015
22
0.055
7
0.018
20
0.05
17
0.043
24
0.06
28
0.07
15
0.038
19
0.048
22
0.055
43
0.108
11
0.028
23
0.058
17
0.043
14
0.035
11
0.028
30
0.075
20
0.05
27
0.068
14
0.035
15
0.038
399
45,417.64
-3.489
-0.000077
P38571
LICH_HUMAN
Lysosomal acid lipase/cholesteryl ester hydrolase (Acid cholesteryl ester hydrolase) (LAL) (EC 3.1.1.13) (Cholesteryl esterase) (Diacylglycerol lipase) (Lipase A) (Sterol esterase) (Triacylglycerol ester hydrolase) (Triacylglycerol lipase)
Homo sapiens (Human)
399
45,419
SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:Q64194}.
acute inflammatory response [GO:0002526]; adaptive thermogenesis [GO:1990845]; adipose tissue development [GO:0060612]; ATP biosynthetic process [GO:0006754]; blood vessel endothelial cell differentiation [GO:0060837]; bone marrow development [GO:0048539]; cell morphogenesis [GO:0000902]; cell proliferation in bone mar...
lipase activity [GO:0016298]; sterol ester esterase activity [GO:0004771]
3.1.1.13
nan
CATALYTIC ACTIVITY: Reaction=a sterol ester + H2O = a sterol + a fatty acid + H(+); Xref=Rhea:RHEA:10100, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15889, ChEBI:CHEBI:28868, ChEBI:CHEBI:35915; EC=3.1.1.13; Evidence={ECO:0000269|PubMed:15269241, ECO:0000269|PubMed:7204383, ECO:0000269|PubMed:8112342}; CATALYTIC ...
nan
SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:Q64194}.
FUNCTION: Catalyzes the deacylation of cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol (PubMed:15269241, PubMed:1718995, PubMed:7204383, PubMed:8112342, PubMed:9633819). Hydrolyzes triglycerides (1,2,3-triacylglycerol) and diglycerides (such as 1,2-diac...
nan
nan
nan
P21675
MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDDECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDESRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGVSENGEGIILPSIIAPSSLASEKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDATKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVECSVESEVSQKSLWNYDYAPP...
1,893
214,711.11
4.953712
0.070787
55.601902
-0.795827
0.339144
0.313788
0.295298
99
0.052
25
0.013
145
0.077
195
0.103
61
0.032
112
0.059
35
0.018
87
0.046
139
0.073
154
0.081
55
0.029
69
0.036
120
0.063
86
0.045
106
0.056
148
0.078
95
0.05
89
0.047
18
0.01
55
0.029
1,893
214,710.81
-96.442
-0.000449
P21675
TAF1_HUMAN
Transcription initiation factor TFIID subunit 1 (EC 2.3.1.48) (EC 2.7.11.1) (Cell cycle gene 1 protein) (TBP-associated factor 250 kDa) (p250) (Transcription initiation factor TFIID 250 kDa subunit) (TAF(II)250) (TAFII-250) (TAFII250)
Homo sapiens (Human)
1,893
214,714
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:2038334, ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:27007846}.
cellular response to ATP [GO:0071318]; cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; midbrain development [GO:0030901]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of gene expression [GO:0010629]; negative regulation of protein autoubiquitination [GO:1905524]; neg...
ATP binding [GO:0005524]; histone acetyltransferase activity [GO:0004402]; histone H4K16ac reader activity [GO:0140046]; kinase activity [GO:0016301]; nuclear receptor binding [GO:0016922]; p53 binding [GO:0002039]; protein heterodimerization activity [GO:0046982]; protein kinase activity [GO:0004672]; protein serine k...
2.3.1.48; 2.7.11.1
nan
CATALYTIC ACTIVITY: Reaction=L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+); Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; CATALYTIC ACTIVITY: Reaction=L-threonyl-[protein]...
nan
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:2038334, ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:27007846}.
FUNCTION: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiatio...
DOMAIN: The Bromo domain mediates interaction with histones that have acetylated lysine residues at specific positions (PubMed:22464331). The second domain also recognizes and binds histones that are butyrylated and crotonylated (PubMed:26365797). {ECO:0000269|PubMed:22464331, ECO:0000269|PubMed:26365797}.
nan
nan
P21926
MPVKGGTKCIKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSIFEQETNNNNSSFYTGVYILIGAGALMMLVGFLGCCGAVQESQCMLGLFFGFLLVIFAIEIAAAIWGYSHKDEVIKEVQEFYKDTYNKLKTKDEPQRETLKAIHYALNCCGLAGGVEQFISDICPKKDVLETFTVKSCPDAIKEVFDNKFHIIGAVGIGIAVVMIFGMIFSMILCCAIRRNREMV
228
25,415.7924
6.801718
0.127193
40.302719
0.487281
0.324561
0.223684
0.429825
17
0.075
10
0.044
8
0.035
13
0.057
19
0.083
21
0.092
3
0.013
24
0.105
16
0.07
20
0.088
8
0.035
9
0.039
4
0.018
7
0.031
5
0.022
9
0.039
9
0.039
16
0.07
3
0.013
7
0.031
228
25,414.89
-0.438
-0.000017
P21926
CD9_HUMAN
CD9 antigen (5H9 antigen) (Cell growth-inhibiting gene 2 protein) (Leukocyte antigen MIC3) (Motility-related protein) (MRP-1) (Tetraspanin-29) (Tspan-29) (p24) (CD antigen CD9)
Homo sapiens (Human)
228
25,416
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19640571}; Multi-pass membrane protein {ECO:0000269|PubMed:19640571}. Membrane {ECO:0000269|PubMed:19640571}; Multi-pass membrane protein {ECO:0000269|PubMed:19640571}. Secreted, extracellular exosome {ECO:0000250|UniProtKB:P40240}. Note=Present at the cell surfac...
cell adhesion [GO:0007155]; cell population proliferation [GO:0008283]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; glial cell migration [GO:0008347]; myoblast fusion involved in skeletal muscle regene...
integrin binding [GO:0005178]
nan
nan
nan
nan
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19640571}; Multi-pass membrane protein {ECO:0000269|PubMed:19640571}. Membrane {ECO:0000269|PubMed:19640571}; Multi-pass membrane protein {ECO:0000269|PubMed:19640571}. Secreted, extracellular exosome {ECO:0000250|UniProtKB:P40240}. Note=Present at the cell surfac...
FUNCTION: Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (PubMed:14575715, PubMed:18541721, PubMed:8478605). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possib...
nan
nan
nan
P21709
MERRWPLGLGLVLLLCAPLPPGARAKEVTLMDTSKAQGELGWLLDPPKDGWSEQQQILNGTPLYMYQDCPMQGRRDTDHWLRSNWIYRGEEASRVHVELQFTVRDCKSFPGGAGPLGCKETFNLLYMESDQDVGIQLRRPLFQKVTTVAADQSFTIRDLVSGSVKLNVERCSLGRLTRRGLYLAFHNPGACVALVSVRVFYQRCPETLNGLAQFPDTLPGPAGLVEVAGTCLPHARASPRPSGAPRMHCSPDGEWLVPVGRCHCEPGYEEGGSGEACVACPSGSYRMDMDTPHCLTCPQQSTAESEGATICTCESGHYRA...
976
108,126.0113
6.198997
0.07582
43.595707
-0.317418
0.286885
0.304303
0.338115
64
0.066
29
0.03
49
0.05
59
0.06
30
0.031
89
0.091
26
0.027
32
0.033
25
0.026
107
0.11
25
0.026
25
0.026
71
0.073
49
0.05
72
0.074
63
0.065
57
0.058
60
0.061
17
0.017
27
0.028
976
108,125.36
-13.413
-0.000124
P21709
EPHA1_HUMAN
Ephrin type-A receptor 1 (hEpha1) (EC 2.7.10.1) (EPH tyrosine kinase) (EPH tyrosine kinase 1) (Erythropoietin-producing hepatoma receptor) (Tyrosine-protein kinase receptor EPH)
Homo sapiens (Human)
976
108,127
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19118217}; Single-pass type I membrane protein {ECO:0000269|PubMed:19118217}.
angiogenesis [GO:0001525]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; negative regulation of cell migration [GO:0030336]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-matrix adhesion [GO:0001954]; pos...
ATP binding [GO:0005524]; fibronectin binding [GO:0001968]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]
2.7.10.1
nan
CATALYTIC ACTIVITY: Reaction=L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+); Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:20101, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:61978, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU100...
nan
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19118217}; Single-pass type I membrane protein {ECO:0000269|PubMed:19118217}.
FUNCTION: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway do...
nan
nan
nan
P21589
MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLNSSIPEDPSI...
574
63,366.9927
6.577886
0.08885
32.585366
-0.08676
0.296167
0.310105
0.381533
36
0.063
10
0.017
32
0.056
29
0.051
24
0.042
50
0.087
15
0.026
36
0.063
35
0.061
58
0.101
12
0.021
31
0.054
27
0.047
17
0.03
23
0.04
38
0.066
26
0.045
48
0.084
7
0.012
20
0.035
574
63,366.23
-2.959
-0.000047
P21589
5NTD_HUMAN
5'-nucleotidase (5'-NT) (EC 3.1.3.35) (EC 3.1.3.5) (EC 3.1.3.89) (EC 3.1.3.91) (EC 3.1.3.99) (5'-deoxynucleotidase) (Ecto-5'-nucleotidase) (IMP-specific 5'-nucleotidase) (Thymidylate 5'-phosphatase) (CD antigen CD73)
Homo sapiens (Human)
574
63,368
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:2129526, ECO:0000269|PubMed:24887587}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:2129526}.
adenosine biosynthetic process [GO:0046086]; ADP catabolic process [GO:0046032]; AMP catabolic process [GO:0006196]; ATP metabolic process [GO:0046034]; calcium ion homeostasis [GO:0055074]; DNA metabolic process [GO:0006259]; inhibition of non-skeletal tissue mineralization [GO:0140928]; leukocyte cell-cell adhesion [...
5'-deoxynucleotidase activity [GO:0002953]; 5'-nucleotidase activity [GO:0008253]; GMP 5'-nucleotidase activity [GO:0050484]; identical protein binding [GO:0042802]; IMP 5'-nucleotidase activity [GO:0050483]; nucleotide binding [GO:0000166]; thymidylate 5'-phosphatase activity [GO:0050340]; zinc ion binding [GO:0008270...
3.1.3.35; 3.1.3.5; 3.1.3.89; 3.1.3.91; 3.1.3.99
nan
CATALYTIC ACTIVITY: Reaction=a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate; Xref=Rhea:RHEA:12484, ChEBI:CHEBI:15377, ChEBI:CHEBI:18254, ChEBI:CHEBI:43474, ChEBI:CHEBI:58043; EC=3.1.3.5; Evidence={ECO:0000269|PubMed:21933152, ECO:0000269|PubMed:22997138, ECO:0000269|PubMed:23142347, ECO:0000269|PubM...
nan
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:2129526, ECO:0000269|PubMed:24887587}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:2129526}.
FUNCTION: Catalyzes the hydrolysis of nucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside, with AMP being the preferred substrate (PubMed:21933152, PubMed:22997138, PubMed:23142347, PubMed:24887587, PubMed:34403084). Shows a preference for ribonucleotide monophosphates over their e...
nan
nan
nan
P21860
MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRDRDAEIVVKDNGRSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGLKMC...
1,342
148,096.7044
6.106065
0.067809
49.606259
-0.387407
0.283159
0.324143
0.315201
70
0.052
60
0.045
63
0.047
91
0.068
35
0.026
122
0.091
46
0.034
45
0.034
51
0.038
134
0.1
34
0.025
58
0.043
93
0.069
51
0.038
81
0.06
99
0.074
69
0.051
84
0.063
15
0.011
41
0.031
1,342
148,096.2
-28.37
-0.000192
P21860
ERBB3_HUMAN
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Homo sapiens (Human)
1,342
148,098
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:33497358}; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cranial nerve development [GO:0021545]; endocardial cushion development [GO:0003197]; epidermal growth factor receptor signaling pathway [GO:0007173]; ERBB2-ERBB3 signaling pathway [GO:0038133]; extrinsic apoptotic signaling pathway in absenc...
ATP binding [GO:0005524]; ErbB-3 class receptor binding [GO:0043125]; growth factor binding [GO:0019838]; identical protein binding [GO:0042802]; neuregulin binding [GO:0038132]; neuregulin receptor activity [GO:0038131]; protein heterodimerization activity [GO:0046982]; protein kinase activity [GO:0004672]; protein ty...
2.7.10.1
nan
CATALYTIC ACTIVITY: Reaction=L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+); Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:20101, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:61978, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000269|PubMed:20351256};
nan
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:33497358}; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
FUNCTION: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778)...
DOMAIN: The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.
nan
nan
P49326
MTKKRIAVIGGGVSGLSSIKCCVEEGLEPVCFERTDDIGGLWRFQENPEEGRASIYKSVIINTSKEMMCFSDYPIPDHYPNFMHNAQVLEYFRMYAKEFDLLKYIRFKTTVCSVKKQPDFATSGQWEVVTESEGKKEMNVFDGVMVCTGHHTNAHLPLESFPGIEKFKGQYFHSRDYKNPEGFTGKRVIIIGIGNSGGDLAVEISQTAKQVFLSTRRGAWILNRVGDYGYPADVLFSSRLTHFIWKICGQSLANKYLEKKINQRFDHEMFGLKPKHRALSQHPTLNDDLPNRIISGLVKVKGNVKEFTETAAIFEDGSRE...
533
60,219.8007
8.413011
0.101313
37.022326
-0.220826
0.307692
0.272045
0.377111
30
0.056
8
0.015
28
0.053
35
0.066
31
0.058
40
0.075
13
0.024
41
0.077
40
0.075
43
0.081
16
0.03
17
0.032
26
0.049
18
0.034
27
0.051
34
0.064
30
0.056
33
0.062
6
0.011
17
0.032
533
60,219.01
4.271
0.000071
P49326
FMO5_HUMAN
Flavin-containing monooxygenase 5 (FMO 5) (Baeyer-Villiger monooxygenase 1) (hBVMO1) (EC 1.14.13.-) (Dimethylaniline monooxygenase [N-oxide-forming] 5) (EC 1.14.13.8) (Dimethylaniline oxidase 5) (NADPH oxidase) (EC 1.6.3.1)
Homo sapiens (Human)
533
60,221
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000305|PubMed:20947616}. Endoplasmic reticulum membrane.
lipid metabolic process [GO:0006629]; regulation of cholesterol metabolic process [GO:0090181]; xenobiotic metabolic process [GO:0006805]
flavin adenine dinucleotide binding [GO:0050660]; monooxygenase activity [GO:0004497]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]; NADPH oxidase H202-forming activity [GO:0106294]
1.14.13.-; 1.14.13.8; 1.6.3.1
nan
CATALYTIC ACTIVITY: Reaction=N,N-dimethylaniline + NADPH + O2 + H(+) = N,N-dimethylaniline N-oxide + NADP(+) + H2O; Xref=Rhea:RHEA:24468, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16269, ChEBI:CHEBI:17735, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.14.13.8; Evidence={ECO:0000269|PubMed:787279...
nan
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000305|PubMed:20947616}. Endoplasmic reticulum membrane.
FUNCTION: Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters (PubMed:20947616, PubMed:26771671, PubMed:28783300). Active on diverse carbonyl compounds, whereas soft nucleophi...
nan
nan
nan
P40222
MKNQDKKNGAAKQSNPKSSPGQPEAGPEGAQERPSQAAPAVEAEGPGSSQAPRKPEGAQARTAQSGALRDVSEELSRQLEDILSTYCVDNNQGGPGEDGAQGEPAEPEDAEKSRTYVARNGEPEPTPVVNGEKEPSKGDPNTEEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELRE...
546
61,890.411
6.14824
0.027473
61.708242
-1.232418
0.432234
0.249084
0.21978
41
0.075
6
0.011
20
0.037
78
0.143
7
0.013
31
0.057
11
0.02
8
0.015
54
0.099
51
0.093
12
0.022
19
0.035
29
0.053
50
0.092
38
0.07
37
0.068
26
0.048
20
0.037
1
0.002
7
0.013
546
61,889.62
-5.47
-0.000088
P40222
TXLNA_HUMAN
Alpha-taxilin
Homo sapiens (Human)
546
61,891
nan
B cell activation [GO:0042113]; exocytosis [GO:0006887]
syntaxin binding [GO:0019905]
nan
nan
nan
nan
nan
FUNCTION: May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells.
nan
nan
nan