Effects of Working Fluids on Operating Characteristics of the Cryogenic Loop Heat Pipe in 180～230 K

Abstract: The cryogenic loop heat pipe is a high-efficiency two-phase heat transfer device that is commonly used in space thermal control systems. In order to investigate the suitable working fluids for LHP in 180～230 K for space exploration applications, the effects of working fluids on the operating characteristics including start-ups, responses of the operating temperatures to the heat load rise, and thermal resistances of the LHP at steady states were researched by employing ethylene, ethane and propylene as fluid candidates. The experimental results and analysis showed that by controlling the temperatures of the evaporator and the compensation chamber at least 10 K below the critical temperatures of the fluids, the LHP achieved successful start-up with heat loads of 5 W. With approximate evaporator temperatures before the start-up, the start-up temperature rise were both within 2 K for the ethane and propylene charged LHP, the start-up time of the ethane charged LHP was less than that of the propylene charged one, and the latent heat and liquid viscosity of working fluids were largely responsible for the differences in the start-up time. The effect of working fluids on the responses of the LHP operating temperatures to the heat load rise was not obvious. The evaporator temperatures decreased and then increased with the rising heat load. The lowest evaporator temperatures occurred with heat loads of 20～30 W, and the time for the LHP to reach the new steady-state decreased with the heat load rise. The pressure drops of the working fluids in the external loop accounted for the significant differences among the heat transfer thermal resistances of the LHP at steady states, and the vapor phase pressure drops took the majority part of the external pressure drops. The smaller vapor pressure drop led to the smaller thermal resistance. The vapor pressure drops of the ethylene charged LHP were less than that of the ethane and then the propylene charged LHP with the same heat loads, and the vapor pressure drops for all three fluids decreased with the increasing temperature. Correspondingly, the thermal resistances of the ethylene charged LHP were less than that of the ethane and then the propylene charged one, all thermal resistances decreased with the rising temperature. The smallest thermal resistance obtained experimentally was 0.21 K/W.


Effects of match period and playing position on the individual and collective dynamics in professional soccer: a case study

Abstract: This study aimed to compare the width, the length, the length per width ratio, and the stretch index between the first and the second halves in official soccer matches, and to compare the spatial exploration index between players from different positions. Seventeen professional soccer players from a Brazilian club participated in the study and were monitored during six official matches by a GPS device. Collective positional data were compared between the two halves using a paired t-test, while the spatial exploration index was compared between the playing positions and within the halves by a mixed two-way ANOVA. The results revealed no differences between the two halves for the collective variables. The highest values of spatial exploration index were reported for central midfielders and wing forwards. We conclude that the tactical behavior of professional soccer players is position-dependent, and midfielders are the most exploratory players on the pitch.

Gibson Moreira Praça
André Gustavo Pereira de Andrade
Sarah da Glória Teles  Bredt
Pedro Emilio Drumond Moreira
Gustavo De Conti Teixeira Costa
Henrique de Oliveira Castro
Rodrigo Aquino

Revista Brasileira de Cineantropometria e Desempenho Humano


Generation X, Y and Z values in Ukraine

Abstract: The paper presents findings of a survey into values of different generations conducted by Academy DTEK jointly with hh.ua|grc During two months of 2019 we polled 2,182 visitors of the Ukrainian Job portal hh.ua|grc (both job seekers and employers), followers of the survey organizers’ pages in social networks (Facebook and Telegram) aged between 15 and 72. The purpose of the study was to find out the central values of young people and older generations of Ukraine. To study the values of generations, the author used Shalom Schwartz’s method of ten fundamental individual values. The method was applied to three different generations. The findings of the poll enabled us to answer questions regarding values and job values of generations X, Y, and Z. What are the similarities and differences of generations, what motivates them at work, and which supervisor is more comfortable for them to work with. The outcome of this survey is a data-oriented database for Ukrainian businesses and the state and public sectors. As the survey shows, the youth upholds values related to individualistic preferences and openness to change: young people strive for new ideas, adventures, and risks and want to be creative and go their own way. The older generation holds values associated with the preservation of traditions and customs, conformity (following rules and norms), and security. Representatives of different generations need different things from their potential supervisors. For instance, Generation Z feels it is essential to be able to ask their supervisor any questions they like, even if they may sound “ridiculous”, and be treated as equals by their supervisor. For Generation Y, their supervisor must discuss professional development issues with them: their goals and expectations concerning career advancement. For Generation X, the supervisor must trust them and build a climate of mutual support and collaboration in the team.

Український соціум

NGO “Ukrainian Institute for Social Research after Olexander Yaremenko”


On NeutroNilpotentGroups

Abstract: In this paper, we introduce the notion of commutator of two elements in a specific NeutroGroup. Then we define the notion of a NeutroNilpotentGroup and we study some of their properties. Moreover, we show that the intersection of two NeutroNilpotentGroups is a NeutroNilpotentGroup. Also, we show that the quotient of a NeutroNilpotentGroup is a NeutroNilpotentGroup. Specially, using NeutroHomomorphism we prove the NeutroNilpotentcy is closed with respect to homomorphic image.

Mathematics
Electronic computers. Computer science


The Effects of N-acetylcysteine on Inflammatory Markers and Homocysteine: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Abstract: Background: Recently a number of trials investigated the effect of N-acetylcysteine (NAC) administration on inflammatory markers and homocysteine (Hcy). However, their findings are controversial. The aim of this paper is to present a meta-analysis and give a review of all randomized controlled trials (RCTs) in order to determine the effects of NAC on inflammatory markers and Hcy. Methods: An electronic search was conducted using PubMed, Scopus, Cochrane Library, Google scholar and Web of Science databases from inception until April 2019. A study quality assessment was performed using the Jadad scale and heterogeneity between studies was statistically computed using Cochrane’s Q test and I-square (I2). Data were pooled using a random-effects model and weighted mean difference (WMD) was considered as the overall effect size.  Results: Out of 1115 potential citations, 10 studies (reported 13 effect sizes for different parameters) met the inclusion criteria and were eligible for this meta-analysis. NAC supplementation resulted in a significant reduction in Hcy levels (WMD: -2.05; 95% CI: -3.73, -0.37). NAC administration did not affect C-reactive protein (CRP) levels (WMD: 0.06; 95% CI: -0.21, 0.34), tumor necrosis factor-α (TNF-α) levels (WMD: 0.07; 95% CI: -0.27, 0.40), and interleukin 6 (IL-6) (WMD: -0.23; 95% CI: -1.23, 0.77). Conclusions: It could be concluded that this meta-analysis of RCTs demonstrated that NAC administration to various patients significantly improved circulating Hcy, but did not affect CRP IL-6 and TNF-α levels.

Jamal Hallajzadeh
Alireza Milajerdi
Željko Reiner
Fariba Kolahdooz
Zatollah Asemi


Neurodevelopmental Disorders Comorbid with Deafness in Children: A Systematic Review of Previous Studies

Abstract: The comorbidity of neurodevelopmental disorders regarding deafness has been confirmed in several studies, which further emphasizes the necessity of paying more attention to diagnostic and rehabilitation approaches in this field. The primary objective of the present study was to provide a systematic review of neurodevelopmental disorders which are associated with deafness in children. The present review study was conducted and obtained through comprehensive search and utilizing keywords including: deafness, comorbid disorder, neurodevelopmental disorder, and hearing impairment in Web of Science, Google Scholar, ScienceDirect databases that had been published between 2009 and 2019. Ultimately, 23 scientific papers were chosen in accordance with the primary objective of the research project and the inclusion criteria & research findings were then extracted. Out of the 24 chosen papers, 13 papers (56.52%) had focused on etiology and the prevalence of disorders, 7 papers (30.43%) had focused on evaluation, 3 papers (13.04%) had focused on rehabilitation and intervention. A. Bearing in mind that comorbid disorders affect the effectiveness of intervention programs and treatments such as hearing aids, cochlear implants, and rehabilitation, it is considered essential to pay close attention to expert evaluations and experts' knowledge & awareness regarding the early diagnosis of comorbid disorders which are associated with deafness


Missing Values in PIMA Diabetes Dataset and Not Considering It in an Article Accepted in that Journal

Abstract: The article is a letter to the editor, so it has no abstract.

مجله انفورماتیک سلامت و زیست پزشکی

Computer applications to medicine. Medical informatics


Encapsulation of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor in liposomes prepared by thin film hydration and their transfer to mesenchymal stem cells and cord blood hematopoietic stem cells

Abstract:
Introduction
Cytokines are important immune modulator factors controlling homeostasis of the body and are involved in tissue regeneration after wound healing. The encapsulation of cytokines in liposomes has many advantages potentially useful for their transfer to the cells. Liposomes protect cytokines from neutralization, improving their pharmacokinetics or biologic activity in vivo. They are targeted to specific cell types and may delay the release of cytokines, allowing their sustained paracrine delivery. Their physicochemical characteristics such as size, shape, charge, and stability are important parameters improving bio-distribution and prolonged pharmacokinetics of encapsulated cytokines.

Material and methods
We developed an efficient protocol for the encapsulation of two types of cytokines, granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF), in liposomes that can be stored long term in the active state.

Results
This method allows for the encapsulation of 12–13% of the total amount of cytokines and 50% of encapsulated cytokines are entrapped in liposomes of more than ≤ 600 nm in diameter. We show that in the studied cell lines the liposome-encapsulated cytokines do not affect cell morphology, proliferation or mortality.

Conclusions
The G-CSF or GM-CSF can be delivered to the cells in working concentrations through the encapsulation in the liposomes. Before the clinical application, the efficiency of these liposomes should be confirmed by an in vivo study.

Sławomir Lewicki
Monika Leśniak
Agnieszka Sobolewska-Ruta
Aneta Lewicka
Marta Grodzik
Eugeniusz K. Machaj
Marek Saracyn
Jacek Z. Kubiak
Zygmunt Pojda


Main causes of bird-window collisions: a review

Abstract: Abstract  Bird-window collisions are a major cause of bird mortality in the world; up to one billion birds die each year from collisions with glass panes in North America alone. However, relatively little attention had been given to this issue in the broad scientific literature, despite a recent increase in the number of papers. In this paper, the indexed literature on bird-window collisions was reviewed, specifically addressing the causal factors. The search retrieved 53 papers, mostly from North America. The factors linked to higher collision rates were large areas of continuous glass, the presence of nearby vegetation and feeders, bird migration, abundance, and behavior. Several factors were site-specific, preventing the global extrapolation of these findings. There is a lack of scientific knowledge regarding bird-window collisions in tropical countries. One of the challenges to mitigating this problem is the small amount of information and – frequently - the extrapolation of findings described for temperate regions to other areas. There is a need for a greater and urgent effort to fill this gap.

LAY G. BASILIO
DANIELE J. MORENO
AUGUSTO J. PIRATELLI

Anais da Academia Brasileira de Ciências


Competitiveness of the Russian space industry in the global space services market

Abstract: The article carries out an analysis of the competitiveness of the Russian space industry in the international space services market according to the following indicators: the volume of budget of national space organizations, the volume of the commercial space exploration market, the number of space launches, positions in manned cosmonautics, production of spacecrafts, deep space exploration, staffing of the space industry and international integration in the space sphere. The paper conducts a SWOT-analysis of the Russian space industry. Its main strengths are: leading positions in manned cosmonautics, leading positions in the number of space launches per year, and extensive experience in space exploration. The greatest concern is caused by: the lack of development of space robotics, insufficient programs for the development of deep space, financial problems and the private sector of Russian cosmonautics, which is in its infancy. The author substantiates the necessity of reforming the Russian space industry.

Вестник университета

Publishing House of the State University of Management

Sociology (General)
Economics as a science


RESTful API Implementation in Making a Master Data Planogram Using the Flask Framework (Case Study: PT Sumber Alfaria Trijaya, Tbk)

Abstract:
One of developingÂ  retail company and is one of the biggest retail companies in Indonesia, namely Alfamart which is owned by PT. Sumber Alfaria Trijaya, Tbk. Alfamart must have the best marketing strategy and increase innovation for the satisfaction of customers in order to survive in high business competition. One strategy to improve marketing is the arrangement of product displays in stores known as planograms. Planogram is a concept that is used in planning the arrangement and placement of products according to certain categories based on consumer spending habits that aim to increase sales at retail. This research was conducted to create a web-based planogram master application using the Flask framework with the python programming language. The method used in this study is the RESTful API, which is the implementation of web services that work through HTTP links. This research produces a web-based master data application that can be used by users in entering data needed in making a planogram.

Keywords: RESTful API, Python Flask, Planogram

JITeCS (Journal of Information Technology and Computer Science)


Preclinical ex-vivo Testing of Anti-inflammatory Drugs in a Bovine Intervertebral Degenerative Disc Model

Abstract: Discogenic low back pain (LBP) is a main cause of disability and inflammation is presumed to be a major driver of symptomatic intervertebral disc degeneration (IDD). Anti-inflammatory agents are currently under investigation as they demonstrated to alleviate symptoms in patients having IDD. However, their underlying anti-inflammatory and regenerative activity is poorly explored. The present study sought to investigate the potential of Etanercept and Tofacitinib for maintaining disc homeostasis in a preclinical intervertebral disc (IVD) organ culture model within IVD bioreactors allowing for dynamic loading and nutrient exchange. Bovine caudal IVDs were cultured in a bioreactor system for 4 days to simulate physiological or degenerative conditions: (1) Phy—physiological loading (0.02–0.2 MPa; 0.2 Hz; 2 h/day) and high glucose DMEM medium (4.5 g/L); (2) Deg+Tumor necrosis factor α (TNF-α)—degenerative loading (0.32–0.5 MPa; 5 Hz; 2 h/day) and low glucose DMEM medium (2 g/L), with TNF-α injection. Etanercept was injected intradiscally while Tofacitinib was supplemented into the culture medium. Gene expression in the IVD tissue was measured by RT-qPCR. Release of nitric oxide (NO), interleukin 8 (IL-8) and glycosaminoglycan (GAG) into the IVD conditioned medium were analyzed. Cell viability in the IVD was assessed using lactate dehydrogenase and ethidium homodimer-1 staining. Immunohistochemistry was performed to assess protein expression of IL-1β, IL-6, IL-8, and collagen type II in the IVD tissue. Etanercept and Tofacitinib downregulated the expression of IL-1β, IL-6, IL-8, Matrix metalloproteinase 1 (MMP1), and MMP3 in the nucleus pulposus (NP) tissue and IL-1β, MMP3, Cyclooxygenase-2 (COX2), and Nerve growth factor (NGF) in the annulus fibrosus (AF) tissue. Furthermore, Etanercept significantly reduced the IL-1β positively stained cells in the outer AF and NP regions. Tofacitinib significantly reduced IL-1β and IL-8 positively stained cells in the inner AF region. Both, Etanercept and Tofacitinib reduced the GAG loss to the level under physiological culture condition. Etanercept and Tofacitinib are able to neutralize the proinflammatory and catabolic environment in the IDD organ culture model. However, combined anti-inflammatory and anabolic treatment may be required to constrain accelerated IDD and relieving inflammation-induced back pain.

Zhen Li
Yannik Gehlen
Yannik Gehlen
Fabian Heizmann
Fabian Heizmann
Sibylle Grad
Mauro Alini
R. Geoff Richards
R. Geoff Richards
David Kubosch
Norbert Südkamp
Kaywan Izadpanah
Eva Johanna Kubosch
Gernot Lang

Frontiers in Bioengineering and Biotechnology


A Novel Peptide Antibiotic Produced by Streptomyces roseoflavus Strain INA-Ac-5812 With Directed Activity Against Gram-Positive Bacteria

Abstract: In this work, we report the isolation and detailed functional characterization for the new non-ribosomally synthesized antibiotic 5812-A/C, which was derived from metabolites of Streptomyces roseoflavus INA-Ac-5812. According to its chemical structure, the studied 5812-A/C preliminary is composed of a cyclic peptide part covalently bounded with an arabinose residue. N-terminal amino acid sequencing of the native peptide has identified its partial structure of Leu-Asp-Gly-Ser-Gly and consisting of a Tyr residue that is supposed to have a two-component peptide nature for the molecule studied. However, the structural analysis of the antibiotic complex derived from S. roseoflavus INA-Ac-5812 is still ongoing. The mechanism of action of 5812-A/C was assessed in comparison with its most related analog, the lipopeptide antibiotic daptomycin, given the presence in both antimicrobials of an L-kynurenine amino acid residue. The inhibitory activity of 5812-A/C against Gram-positive bacteria including methicillin-resistant strain of Staphylococcus aureus was similar to daptomycin. The mechanism of action of 5812-A/C was associated with the disruption of membrane integrity, which differs in comparison with daptomycin and is most similar to the antimicrobial membrane-disturbing peptides. However, 5812-A/C demonstrated a calcium-dependent mode of action. In addition, unlike daptomycin, 5812-A/C was able to penetrate mature biofilms and inhibit the metabolic activity of embedded S. aureus cells. At the same time, 5812-A/C has no hemolytic activity toward erythrocyte, but possessed weak cytotoxic activity represented by heterochromatin condensation in human buccal epithelium cells. The biological properties of the peptide 5812-A/C suggest its classification as a calcium-dependent antibiotic effective against a wide spectrum of Gram-positive pathogenic bacteria.

Alexey S. Vasilchenko
William T. Julian
Olda A. Lapchinskaya
Genrikh S. Katrukha
Vera S. Sadykova
Eugene A. Rogozhin
Eugene A. Rogozhin


Investigation of Non-Isothermal Kinetics and Thermodynamic Parameters for the Pyrolysis of Different Date Palm Parts

Abstract: Using the thermalgravimetric technique, we investigated the non-isothermal combustion kinetics of abundant and low-cost date palm wastes (leaflet, rachis, fibers, and their composite) as potential biomass energy sources. The kinetic and thermodynamic parameters were determined by Flynn–Wall–Ozawa (FWO), Kissinger–Akahila–Sunose (KAS), and Starink methods. Thermogravimetric analysis results showed a major peak for the degradation of volatiles between 127–138 °C with average percentage mass loss of 68.04 ± 1.5, 65.57 ± 0.6, 62.97 ± 5.5, and 59.26 ± 3.2, for rachis, composite, leaflet, and fibers, respectively. The FWO model showed the lowest activation energy, Eα, of 157 ± 25.6, 158 ± 25.7, 164 ± 40.1, and 169 ± 51.8 kJ mol−1 for the composite, rachis, leaflet, and fibers, respectively. The positive enthalpy values confirmed an endothermic pyrolysis reaction. For all models, a minimal difference of 4.40, 5.57, 6.55, and 7.51 kJ mol−1 between activation energy and enthalpy for rachis, fibers, composite, and leaflet ensued, respectively. The KAS model was best suited to describe chemical equilibrium with average ΔG values of 90.3 ± 28.8, 99.3 ± 34.9, 178.9 ± 27.3, and 186.5 ± 38.2 kJ mol−1 for rachis, fibers, composite, and leaflet, respectively. The reaction mechanism by the Malek and Popescu methods was ((<inline-formula><math display="inline"><semantics><mrow><mi>g</mi><mrow><mo>(</mo><mi mathvariant="sans-serif">α</mi><mo>)</mo></mrow><mo>=</mo><mrow><mo>[</mo><mrow><mo>−</mo><mi>ln</mi><mrow><mo>(</mo><mrow><mn>1</mn><mo>−</mo><mi mathvariant="sans-serif">α</mi></mrow><mo>)</mo></mrow><msup><mo stretchy="false">]</mo><mrow><mfrac><mn>1</mn><mn>4</mn></mfrac></mrow></msup></mrow><mo>)</mo></mrow></mrow></semantics></math></inline-formula> across the conversion range of 0.1–0.9 for all heating rates. The high energy content and volatile matter combined with low energy barriers make date palm waste a potential candidate in a biorefinery.

Emmanuel Galiwango
Ali H. Al-Marzuoqi
Abbas A. Khaleel
Mahdi M. Abu-Omar


WATER-RISK MANAGEMENT IN TCHOGHA ZANBIL WORLD HERITAGE SITE IN IRAN, WITH A FOCUS ON THE ANCIENT MANAGEMENT SYSTEM

Abstract: Water-risk management is one of the most challenging issues in the conservation of earthen sites, because of the inherent weakness of earth to moisture, and also the severe damage after rainfall as a result of a combination of many factors in the deterioration processes. In Tchogha Zanbil World Heritage Site (WHS) in Iran, this problem causes more damage due to the heavy rains that impact the site in a short period of time. The property encompasses a vast area, which makes regular maintenance more difficult. Also, there are insufficient strategies for controlling water runoff on the structures. Archaeological studies have revealed an ancient system for managing surface water at this site which could be compatible and adaptable for further development of the current management system. This study aims to present sustainable approaches in managing water-risk in the Tchogha Zanbil WHS, by identifying the authenticity values, investigating the problems and challenges in the current water-management system, and more importantly, assessing ancient strategies for controlling water, based on archaeological evidence.

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences

Engineering (General). Civil engineering (General)


Pre-clinical modeling of cutaneous melanoma

Abstract: Despite the new targeted and immunotherapies for metastatic melanoma, several patients show therapeutic plateau. Here, the authors review the current pre-clinical models of cutaneous melanoma and discuss their strengths and limitations that may help with overcoming therapeutic plateau.

Vito W. Rebecca
Rajasekharan Somasundaram
Meenhard Herlyn


Apendicostomia ensanchada

Abstract: Presentado en la Sesión del 27 de Abril de 1949.


Application of Instrumented Paddles in Measuring On-Water Kinetics of Front and Back Paddlers in K2 Sprint Kayaking Crews of Various Ability Levels

Abstract: This study used instrumented paddles to obtain on-water kinetic variables of two-seater (K2) crews during sprint kayaking. A total of 74 male kayakers of various ability levels (national team: 9, recreational club: 38, school team: 27) comprising 39 K2 crews were recruited. Both the front and back paddlers were provided with an instrumented paddle to perform 200-m maximal effort paddling in a reservoir. Force, power, and temporal variables were extracted from the paddle data. Difference among groups were compared using a factorial Analysis of Variance. Results showed that the force, power, and temporal characteristics of the front and back paddlers were similar during maximal effort sprint kayaking. Proficient kayakers produced greater kinetic outputs than less proficient kayakers, while the coordination strategy based on timing differences at key events between the two crew members in a K2 boat was similar across ability levels. These data can be useful for coaches, sport scientists, and athletes in planning and monitoring the training.

Pui Wah Kong
Cheryl Sihui Tay
Jing Wen Pan


A New Technique for Understanding Large-Scale Software Systems

Abstract: Comprehending a huge execution trace is not a straightforward task due to the size of data to be processed. Detecting and removing utilities are useful to facilitate the understanding of software and decrease the complexity and size of the execution trace. The goal of this study is to develop a novel technique to minimize the complexity and the size of traces by detecting and removing utilities from the execution trace of object-oriented software. Two novel utility detection class metrics were suggested to decide the degree that a specific class can be counted as a utility class. Dynamic coupling analysis forms the basis for the proposed technique to address object-oriented features. The technique presented in this study has been tested by two case studies to evaluate the effectiveness of the proposed technique. The results from the case studies show the usefulness and effectiveness of our technique.

Telecommunications Society, Academic Mind


The value of face-to-face communication in the digital world: What people miss about in-person interactions when those are limited

Abstract: Face-to-face communication is important for building and maintaining relationships. The COVID-19 pandemic led to severe limitations in people’s face-to-face interactions, resulting in most people relying more heavily on digital communication for social connection. Existing research has contributed to the understanding of how face-to-face communication is used alongside digital communication. However, we know little about what elements of face-to-face interactions people miss especially when in-person meetings are heavily reduced, and how this is related to their use of digital communication for social connection. In this study, we draw upon survey data that we collected in spring 2020 from a national sample of U. S. adults to answer these questions. We find that most people missed elements of face-to-face interactions and particularly valued spontaneous interactions, physical closeness, and independence from technology about in-person interactions. More frequent and increasing use of popular digital modes such as voice calls, video calls, text messages, and social media were all positively related to missing face-to-face communication. Our results contribute to the understanding of the role and value of in-person interactions in a digital world.

Jonathan Gruber
Eszter Hargittai
Minh Hao Nguyen

Communication. Mass media
Social Sciences


Model of cultivating patriotism in adolescents and "generation Z" youth using the resource of juvenile media

Abstract: Introduction. The conducted research is aimed at identifying the methodological foundations, content, methods and mechanisms for organizing the patriotic education in adolescents and "Z generation" youth. The article defines the essential characteristics of the education processes and creation of juvenile media, and substantiates the possibility and potential of integrating these processes. Theoretical analysis. The scientific novelty lies in the development and theoretical justification of the Model of organizing the patriotic education in the “Generation Z” youth with the involvement of the juvnile media resource, which includes methodological, target-oriented, activity and result blocks, and which is based on a combination of humanistic, personal, activity, and integrative approaches to the process of educating adolescents, allowing to ensure the integrity and functionality of the Model. The mechanism of education is the pedagogical support of the value-semantic self-determination of a young person at each stage of a young media journalist work on media material. In the process of creating media material, a chain of upbringing methods is used (according to Z. I. Vasilyeva): goal-setting – informational and educational – evaluative. Conclusion. As a result of the study, the possibility of using the potential of juvenile media in the process of patriotic education in generation Z teenagers is substantiated: the purpose, the main mechanism, the content and methods of the upbringing process, the structure and indicators of the result of the patriotic upbringing of adolescents and the "Generation Z" youth with the involvement of the juvenile media resource.

Kosolapova, Larisa Alexandrovna
Myasnikova, Diana Igorevna

Известия Саратовского университета. Новая серия: Серия Философия. Психология. Педагогика


Personal Protective Equipment-Related Nasal Bridge Folliculitis in a Corona Warrior

Abstract: Nasal bridge is a common site suffering personal protective equipment-induced skin damages over face among first-line health care workers in this coronavirus disease 2019 pandemic. We hereby report folliculitis as a complication following regular use of N95 respirator and goggles, unreported in literature till now.

Rajeev Sharma
Ashish Bindra
Kapil Dev Soni

Thieme Medical and Scientific Publishers Pvt. Ltd.

Neurology. Diseases of the nervous system


The principle of the 3Rs between aspiration and reality

Abstract: The Principle of the 3Rs is widely recognised as the methodological and ethical backbone of contemporary animal research. Different authors also stress the reciprocal links among the 3Rs, and how these often complement and reinforce each other. We very much agree with this point, but in this contribution we would like to raise some problems related to the application of the “3Rs”. There is an obvious link among “Replacement, “Reduction” and “Refinement”, but it is worth to notice also that each “R” has its own conceptual characteristics, as well as its own level of applicability. For example, a realistic “methodological inertia” has to be expected more in the case of “Replacement” than in the case of “Refinement”. This also leads to a second order of issues, and here we will offer our experience as projects evaluators. The “3Rs” differ also in the possibility to verify how are applied by the proponents of research protocols involving the use of animal models. Sometimes it appears that the application of the Principle still resolves itself in the use of formulaic sentences, from which it is difficult to really understand the reality of the laboratory decisional and procedural processes. However, the demanding characteristics of the “3Rs” can vary greatly, and this is something that has to be considered. We propose that a network, or a virtual platform, of evaluators could help both researchers and evaluators for a more satisfactory understanding and pragmatic application of the Principle of the 3Rs.


Voice Syncretism Crosslinguistically: The View from Minimalism

Abstract: Voice syncretism is widely attested crosslinguistically. In this paper, we discuss three different types of Voice syncretism, under which the same morpheme participates in different configurations. We provide an approach under which the same Voice head can convey different interpretations depending on the environment it appears in, thus building on the notion of allosemy. We show that, in all cases under investigation, allosemy is closely associated with the existence of idiosyncratic patterns. By contrast, we notice that allosemy and idiosyncrasy are not present in analytic passive and causative constructions across different languages. We argue that the distinguishing feature between the two types of constructions is whether the passive and the causative interpretation comes from the Voice head, thus forming a single domain with the vP or whether passive and causative semantics are realized by distinct heads above the Voice layer, thus forming two distinct domains.


A six‐port network based on substrate integrated waveguide coupler with metal strips

Abstract: Abstract In this study, a novel coupling structure based on half‐mode substrate‐integrated waveguide (HMSIW) is proposed with a small size and broad bandwidth. The HMSIW coupler is realised by connecting their equivalent magnetic walls with metal strips, which avoids exposing the semi‐enclosed magnetic walls outside. Hence, it has greater anti‐interference capability than the existing HMSIW couplers. The directional coupling principle is introduced by analysing the proposed single connecting strip coupler. In order to lower return loss and higher isolation, a 3 dB directional coupler working from 10.8 to 16.8 GHz is designed with two connecting strips. Finally, a six‐port circuit is achieved by utilising this compact 3 dB directional coupler. Furthermore, a broadband HMSIW power divider is optimised to satisfy the performance of this six‐port circuit. The proposed coupler with metal strips helps to increase bandwidth and reduce size, which makes it more applicable to demanding systems with complex requirements such as detecting and transceiver systems. The 3 dB coupler and six‐port circuit are fabricated and measured. The measured results are in accordance with the simulated data.

Telecommunication
Electricity and magnetism


Development of Mathematics E-Comic  to Facilitate the Mathematical Communication Ability

Abstract: This study aims to develop a valid mathematics e-comic learning media for class VIII students on statistical material. The design of the e-comic mathematics learning media development using the PPE stage includes planning (planning), production (production), and evaluation (evaluation). The criteria for achieving quality are carried out by testing so that they are declared valid by experts. The results showed that the e-comic learning media for class VIII students on statistics material for class VIII students on statistics material met the valid criteria. Product validity was obtained based on the assessment of experts which showed that the quality of the learning media was included in the very good category with an average score of 3.65 by the material expert validator, and was included in the very good category with an average score of 3.75 by the media expert validator. Based on the results of the assessment, it can be concluded that the e-comic learning media for class VIII students on statistical material is valid.

Institut Agama Islam Negeri (IAIN) Salatiga


Hypoxia-Inducible Expression of Annexin A6 Enhances the Resistance of Triple-Negative Breast Cancer Cells to EGFR and AR Antagonists

Abstract: Physiological changes such as hypoxia in the tumor microenvironment (TME) endow cancer cells with malignant properties, leading to tumor recurrence and rapid progression. Here, we assessed the effect of hypoxia (1% Oxygen) on the tumor suppressor Annexin A6 (AnxA6) and the response of triple-negative breast cancer (TNBC) cells to epidermal growth factor receptor (EGFR) and androgen receptor (AR) targeted therapies. We demonstrate that brief exposure of TNBC cells to hypoxia (within 24 h) is associated with down regulation of AnxA6 while > 24 h exposure cell type dependently stimulated the expression of AnxA6. Hypoxia depicted by the expression and stability of HIF-1/2α led to up regulation of the HIF target genes SLC2A1, PGK1 as well as AR and the AR target genes FABP-4 and PPAR-γ, but the cellular levels of AnxA6 protein decreased under prolonged hypoxia. Down regulation of AnxA6 in TNBC cells inhibited, while AnxA6 over expression enhanced the expression and cellular levels of HIF-1/2α, SLC2A1 and PGK1. RNAi mediated inhibition of hypoxia induced AnxA6 expression also strongly inhibited glucose uptake and ROS production in AnxA6 expressing TNBC cells. Using a luciferase reporter assay, we confirm that short-term exposure of cells to hypoxia inhibits while prolonged exposure of cells to hypoxia enhances AnxA6 promoter activity in HEK293T cells. Compared to cells cultured under normoxia, TNBC cells were more resistant to lapatinib under hypoxic conditions, and the downregulation of AnxA6 sensitized the cells to EGFR as well as AR antagonists. These data suggest that AnxA6 is a hypoxia inducible gene and that targeting AnxA6 upregulation may be beneficial in overcoming TNBC resistance to EGFR and/or AR targeted therapies.

Stephen D. Williams
Tunde M. Smith
LaMonica V. Stewart
Amos M. Sakwe


Vaccinating the world against COVID-19 is a no-brainer


Role of water structure in alkaline water electrolysis

Abstract: Summary: Herein, with the help of experimental and first-principles density functional theory (DFT)-based studies, we have shown that structural changes in the water coordination in electrolytes having high alkalinity can be a possible reason for the reduced catalytic activity of platinum (Pt) in high pH. Studies with polycrystalline Pt electrodes indicate that electrocatalytic HER activity reduces in terms of high overpotential required, high Tafel slope, and high charge transfer resistances in concentrated aqueous alkaline electrolytes (say 6 M KOH) in comparison to that in low alkaline electrolytes (say 0.1 M KOH), irrespective of the counter cations (Na+, K+, or Rb+) present. The changes in the water structure of bulk electrolytes as well as that in electrode-electrolyte interface are studied. The results are compared with DFT-based analysis, and the study can pave new directions in studying the HER process in terms of the water structure near the electrode-electrolyte interface.

Anku Guha
Mihir Sahoo
Khorsed Alam
D. Krishna Rao
Prasenjit Sen
Tharangattu N. Narayanan


Optimal Deployment of Dynamic Wireless Charging Lanes for Electric Vehicles considering the Battery Charging Rate

Abstract: Dynamic wireless charging (DWC) technology enables the charging of electric vehicles (EVs) en route without the need for stopping on long-distance trips. Based on DWC technology, a dynamic wireless charging system (DWCS) concept is proposed to determine the number of DWC lanes and their locations and lengths considering varying battery charging rates. A two-stage approach is proposed to design the optimal DWCS. First, we propose a mixed-integer model with nonlinear constraints to determine the locations and lengths of the charging lanes. This model is further reformulated as a mixed-integer linear problem to make it suitable to solve with off-the-shelf commercial solvers (e.g., Gurobi). Next, we propose a method to obtain an approximately optimal solution for the number of lanes. Then, a numerical example from a freeway in Guangdong Province, China, is investigated to demonstrate the applicability of the proposed model and its effectiveness in reducing the construction costs.

Transportation engineering
Transportation and communications


Effect of the Temperature and Oxidation Time on Some Physicochemical Characteristics of the Rice Bran Oil

Abstract:
Due to their excellent characteristics, vegetable oils are successfully used in various formulations of organic lubricants. In this context, the advanced biodegradability and excellent lubricity performance of rice oil leads to its being considered as a real potential for the lubricants industry. However, as with other vegetable oils, the stability of rice bran oil is strongly influenced by the oxidation process. Therefore, the aim of this work was the oxidation stability monitorization of rice bran oil by spectrophotometric techniques. For this purpose, oxidation tests of rice bran oil at elevated temperatures were performed.
In this paper, transmittance spectra were determined, and the trichromatic components and coordinates were calculated, as well as the colour differences for rice oils subjected to a forced oxidation treatment at temperatures of 100 °C and 120 °C for 4, 8 and 10 hours. The results obtained show that, although after the first 4 hours of forced oxidation significant changes appear on the physicochemical properties of rice bran oil, an increase in the test time from 8 to 10 hours does not lead to significant changes in the analysed parameters, the conclusion being valid for both test temperatures.

The Annals of “Dunarea de Jos” University of Galati. Fascicle IX, Metallurgy and Materials Science


Chimeric antigen receptor T‐cell therapy: Challenges and framework of outpatient administration

Abstract: Abstract Adoptive cellular therapy has made a landmark change within the treatment paradigm of several hematologic malignancies, and novel cellular therapy products, such as chimeric antigen receptor T‐cell therapy (CART), have demonstrated impressive efficacy and produced durable responses. However, the CART treatment process is associated with significant toxicities, healthcare resource utilization, and financial burden. Most of these therapies have been administered in the inpatient setting due to their toxicity profile. Improved toxicity management strategies and a better understanding of cellular therapy processes are now established. Therefore, efforts to transition CART to the outpatient setting are warranted with the potential to translate into enhanced patient quality of life and cost savings. A successful launch of outpatient CART requires several components including a multidisciplinary cellular therapy team and an outpatient center with appropriate clinical space and personnel. Telemedicine should be incorporated for closer monitoring. Additionally, clear criteria for admission upon clinical decompensation, a pathway for prompt inpatient transition, and clear toxicity management guidelines should be implemented. Effective education about cellular therapy and toxicity management is imperative, especially for the Emergency Department and Intensive Care Unit teams. Here, we have outlined the various logistical and clinical considerations required for the care of CART patients, which will aid centers to establish an outpatient CART program.

Katie S. Gatwood
Bhagirathbhai R. Dholaria
Mariana Lucena
Brittney Baer
Bipin N. Savani
Olalekan O. Oluwole

Diseases of the blood and blood-forming organs


Membangun Ekowisata Berbasis Perhutanan Sosial di Desa Talaga Paca, Kabupaten Halmahera Utara

Abstract: Talaga Paca Village has natural tourism potential such as lake, cave, forest and biodiversity. The existing of the natural wealth is inversely proportional to the economic welfare of the people who have a poverty rate of 75%. The community has not received the economic benefits from the beautiful nature around them. In 2019, the Ministry of Environment and Forestry gave an approval for the management of a state forest area of 865 ha during 35 years to Talaga Paca Village as part of the Social Forestry program. The Community Service (CS) Team of Halmahera University identified the main problem of the community was the inability to manage the tourism potential. The purpose of this CS is to implement the management of Talaga Paca ecotourism by the community so that they could receive the economic benefits for their welfare. The CS took place from April to October 2022. Through the collaboration of the parties, the CS has succeeded in improving the management of ecotourism by the community. At the moment, there have been tourist visits from within and outside the country so that the community has begun to receive economic benefits from ecotourism.

Radios  Simanjuntak
Radios  Simanjuntak
Novri Wangka
Eppi Manik

Technology (General)
Social Sciences
Social sciences (General)


Does ESG Disclosure Help Improve Intangible Capital? Evidence From A-Share Listed Companies

Abstract: With the disclosure of ESG, the investment related to ESG disclosure has increased, and the trend of changes in intangible capital has shown an “inverted S-shaped” curve. The research shows that, in the initial stage of investment in ESG construction, new ESG investments increase intangible capital. With the increase in ESG investment and the advancement of time, the positive effect of the increase in ESG scores on intangible capital begins to appear and gradually offsets the cost of ESG investment. However, when the ESG score of a company is raised to a certain level, the marginal effect of continuing to increase ESG investment will reduce the increase in intangible capital.

Wu Jun
Zheng Shiyong
Zheng Shiyong
Tang Yi


Disseminated abdominal echinococcosis: Case report

Abstract: We describe a case of disseminated abdominal hydatid disease in a 21-year-old man who presented with clinical symptoms of persistent abdominal pain after abscess drainage post-appendectomy. The images showed multiple cystic lesions in the peritoneum, liver, and spleen. Due to pain exacerbation, the patient was taken to laparotomy. Multiple cystic lesions scattered throughout the abdominal cavity were observed, which were diagnosed by histopathology as multiple cystic lesions due to peritoneal and abdominal echinococcosis.

Gabriela Evers S
Héctor Adolfo Polania Liscano
Santiago  Adolfo Polania Galindo

Asociación Colombiana de Gastroenterología

Diseases of the digestive system. Gastroenterology


Strategi Pengembangan Kampung Topeng Malang  sebagai Kampung Wisata Budaya

Abstract: The Desaku Menanti Program is a government program that is relocating the homeless to a new village as a tourist destination, one of the results of the program is the Mask Tourism Village. The potential of Malangan Mask cultural characteristics to be the main attraction of this tour was able to attract many visitors at the beginning of its inauguration. But it didn't last long, now the village is deserted and no one even comes. This research will examine how the strategy of developing Kampung Mask as a cultural tourism village. The method used is a mix-method, namely a qualitative method with SWOT and a quantitative method with an analysis of tourist needs preferences for cultural tourism villages with questionnaire. The results of the study indicate that this village needs to dig deeper into the concept of culture, improve the quality of its facilities, and also have a well-managed tourism management with community participation. Based on the analysis of tourist preferences, it was found that if it was necessary to add facilities and other cultural attractions, 49% of respondents chose the visual characteristics of settlements with traditional buildings and accommodation was villas in nature.

Magvira Ardhia Pratiwi
Novi Sunu Sri Giriwati
Yusfan Adeputera Yusran
Herry Santosa

Architectural engineering. Structural engineering of buildings


The Development of an Achievement Test Towards “Reproduction, Growth and Development in Plants and Animals” Subject


New Meanings of Computer-Based Entertainment and Communication among Students in Poland During the COVID-19 Pandemic

Abstract: This article is an attempt at investigating new meanings and significance of computer-based entertainment during the COVID-19 pandemic. The authors explore how and to what extent students in Poland have been using electronics for entertainment during the global crisis, what emotions appeared and whether they were able and willing to engage in an auto-reflexive process. The article presents the results of the questionnaire interview designed for the purposes of this particular study. The authors chose to reveal the multi-facetedness of the theme in question, i.e. focus on the possibilities and the future that computer-based etertainment offers, leading to transformations both externally and internally.

Mokras-Grabowska Justyna
Mroczek-Żulicka Aleksandra
Olasik Marta


Optimization of False Target Jamming against UAV Detection

Abstract: Unmanned aerial vehicles (UAVs) have been widely used for target detection in modern battlefields. From the viewpoint of the opponents, false target jamming is an effective approach to decrease the UAV detection ability or probability, but currently there are few research efforts devoted to this adversarial problem. This paper formulates an optimization problem of false target jamming based on a counterpart problem of UAV detection, where each false target jamming solution is evaluated according to its adversarial effects on a set of possible UAV detection solutions. To efficiently solve the problem, we propose an evolutionary framework, which is implemented with four popular evolutionary algorithms by designing/adapting their evolutionary operators for false target jamming solutions. Experimental results on 12 test instances with different search regions and numbers of UAVs and false targets demonstrate that the proposed approach can significantly reduce the UAV detection probability, and the water wave optimization (WWO) metaheuristic exhibits the best overall performance among the four evolutionary algorithms. To our knowledge, this is the first study on the optimization of false target jamming against UAV detection, and the proposed framework can be extended to more countermeasures against UAV operations.

Zheng-Lian Su
Xun-Lin Jiang
Ning Li
Hai-Feng Ling
Yu-Jun Zheng

Motor vehicles. Aeronautics. Astronautics


Aerosolized polymyxins for ventilator-associated pneumonia caused by extensive drug resistant Gram-negative bacteria: class, dose and manner should remain the trifecta

Jean-Jacques Rouby
Yinggang Zhu
Antoni Torres
Jordi Rello
Antoine Monsel

Medical emergencies. Critical care. Intensive care. First aid


إدارة البيانات الضخمة فى المکتبات العامة المصرية

Abstract: هدفت هذه الدراسة الى معرفة أنواع التحليلات الفعلية المستخدمة بالمکتبات العامة المصرية, وتحديد مدى معرفة العاملين بالمکتبات العامة المصرية بموضوع البيانات الضخمة, وتحليلاتها, والتعرف على مصادر البيانات الضخمة بالمکتبات العامة المصرية, وتحديد مجالات تطبيق تحليلات البيانات الضخمة بالمکتبات العامة, ومدى تقبل الإدارات لتطبيق تحليلات البيانات الضخمة بمکتباتهم, وکذلک مدى تقبل العاملين والادارة لاستحداث قسم خاص بتحليل البيانات الضخمة بالمکتبات العامة, وتطبيق التحليل الرباعى لمعرفة الفرص والتحديات التى تواجه تطبيق تحليلات البيانات الضخمة بالمکتبات العامة المصرية، ومن أهم النتائج التى توصلت إليها الدراسة أن المکتبات العامة المصرية تتمتع المکتبات العامة المصرية ببنية تحتية وتکنولوجية لا بأس بها تؤهلها لتطبيق تحليلات البيانات الضخمة، و تتقبل الإدارات فکرة تطبيق تحليلات البيانات الضخمة بالمکتبات العامة المصرية بنسبة عالية , تصل إلى (85.7%) من إجمالى نسب عينة الدراسة، و تتقبل إدارة المکتبات العامة المصرية مقترح استحداث قسم خاص بتحليلات البياات الضخمة بالمکتبات، يعتبر النظام الآلى المستخدم بالمکتبات العامة المصرية, وما يحويه من بيانات أحد مصادر البيانات الضخمة بالمکتبات، يعتبر من أکبر المصادر التى استمد منها اخصائيو المکتبات العامة معرفتهم بالبيانات الضخمة - هى مواقع وصفحات الإنترنت بنسبة (65.8%.)، والبعض منهم عرف البيانات الضخمة من المقالات العلمية وزملاء التخصص بنسبة 55.3%. وباقى مصادر المعرفة من خلال مواقع التواصل الاجتماعى, وورش العمل.

الحسن شعبان احمد

الحسن شعبان احمد

المجلة العربية الدولية لتكنولوجيا المعلومات والبيانات

Arab Institution for Knowledge Management

Bibliography. Library science. Information resources


Development of Rice Variety With Durable and Broad-Spectrum Resistance to Blast Disease Through Marker-Assisted Introduction of Pigm Gene

Abstract: Rice blast, caused by Magnaporthe oryzae (M. oryzae), is one of the most destructive diseases threatening rice production worldwide. Development of resistant cultivars using broad-spectrum resistance (R) genes with high breeding value is the most effective and economical approach to control this disease. In this study, the breeding potential of Pigm gene in geng/japonica rice breeding practice in Jiangsu province was comprehensively evaluated. Through backcross and marker-assisted selection (MAS), Pigm was introduced into two geng rice cultivars (Wuyungeng 32/WYG32 and Huageng 8/HG8). In each genetic background, five advanced backcross lines with Pigm (ABLs) and the same genotypes as the respective recurrent parent in the other 13 known R gene loci were developed. Compared with the corresponding recurrent parent, all these ABLs exhibited stronger resistance in seedling inoculation assay using 184 isolates collected from rice growing regions of the lower region of the Yangtze River. With respect to panicle blast resistance, all ABLs reached a high resistance level to blast disease in tests conducted in three consecutive years with the inoculation of seven mixed conidial suspensions collected from different regions of Jiangsu province. In natural field nursery assays, the ABLs showed significantly higher resistance than the recurrent parents. No common change on importantly morphological traits and yield-associated components was found among the ABLs, demonstrating the introduction of Pigm had no tightly linked undesirable effect on rice economically important traits and its associated grain weight reduction effect could be probably offset by others grain weight genes or at least in the background of the aforementioned two varieties. Notably, one rice line with Pigm, designated as Yangnonggeng 3091, had been authorized as a new variety in Jiangsu province in 2021, showing excellent performance on both grain yield and quality, as well as the blast resistance. Together, these results suggest that the Pigm gene has a high breeding value in developing rice varieties with durable and broad-spectrum resistance to blast disease.

Zhiming Feng
Zhiming Feng
Mingyou Li
Zhiwen Xu
Peng Gao
Yunyu Wu
Keting Wu
Jianhua Zhao
Xiaoqiu Wang
Jianan Wang
Mengchen Li
Keming Hu
Keming Hu
Hongqi Chen
Yiwen Deng
Aihong Li
Zongxiang Chen
Zongxiang Chen
Shimin Zuo
Shimin Zuo
Shimin Zuo


CSR and CEO’s Moral Reasoning in the Automotive Industry in the Era of COVID-19

Abstract: This paper assesses whether and to which extent the COVID-19 pandemic, which represents a scenario of high moral intensity, is influencing the moral reasoning of top CEOs (chief executive officers) in the paradigmatic case of the automotive industry and how this moral reasoning relates to their CSR response to the crisis and their CSR plans in the long run. To this end, we took the CEO letters before and after the pandemic outbreak of the top 15 automotive companies, and applied Weber’s method to conduct a moral reasoning categorization, along with an examination of their CSR approach and initiatives. The results show a predominant moral paralysis among these CEOs, where positive reactions addressed are philanthropic in nature and more likely to be a transient response to the crisis, rather than a sustained long-term improvement of their CSR rooted in a significant moral approach enhancement. Furthermore, CEOs at the lowest stages of moral reasoning, primarily focused on their own business and immediate stakeholders, are less likely to highlight these philanthropic initiatives. The outcome evidences the convenience of addressing CSR from the lens of moral reasoning, and it further draws the attention of the scientific community, companies and their top management, stakeholders, and society to the relevance of investigating and considering the moral reasoning of top management in large corporations and its implications.

Beatriz Garcia-Ortega
Javier Galan-Cubillo
Blanca de-Miguel-Molina

History of scholarship and learning. The humanities


Ion Mobility Mass Spectrometry Reveals Rare Sialylated Glycosphingolipid Structures in Human Cerebrospinal Fluid

Abstract: Gangliosides (GGs) represent an important class of biomolecules associated with the central nervous system (CNS). In view of their special role at a CNS level, GGs are valuable diagnostic markers and prospective therapeutic agents. By ion mobility separation mass spectrometry (IMS MS), recently implemented by us in the investigation of human CNS gangliosidome, we previously discovered a similarity between GG profiles in CSF and the brain. Based on these findings, we developed IMS tandem MS (MS/MS) to characterize rare human CSF glycoforms, with a potential biomarker role. To investigate the oligosaccharide and ceramide structures, the ions detected following IMS MS separation were submitted to structural analysis by collision-induced dissociation (CID) MS/MS in the transfer cell. The IMS evidence on only one mobility feature, together with the diagnostic fragment ions, allowed the unequivocal identification of isomers in the CSF. Hence, by IMS MS/MS, GalNAc-GD1c(d18:1/18:1) and GalNAc-GD1c(d18:1/18:0) having both Neu5Ac residues and GalNAc attached to the external galactose were for the first time discovered and structurally characterized. The present results demonstrate the high potential of IMS MS/MS for biomarker discovery and characterization in body fluids, and the perspectives of method implementation in clinical analyses targeting the early diagnosis of CNS diseases through molecular fingerprints.

Mirela Sarbu
Dragana Fabris
Željka Vukelić
David E. Clemmer
Alina D. Zamfir


Application of Convolutional Neural Network for Fault Diagnosis of Bearing Scratch of an Induction Motor

Abstract: The demand for the condition monitoring of induction motors is increasing in various fields, such as industry, transportation, and daily life. Bearing faults are the most common faults, and many fault diagnosis methods have been proposed using artificial pitting as the fault factor in most cases. However, the validity of a fault diagnosis method for other kinds of faults does not seem to be evaluated. Considering onsite scenarios and other possibilities of faults, this paper introduces scratches on the outer raceways of bearings. A study was performed on the detection of several kinds of bearing scratches using a proposed method that was based on an auto-tuning convolutional neural network. The developed approach was also compared with other diagnostic methods for validation. The results showed that the proposed technique provides the possibility of diagnosing several kinds of scratches with acceptable accuracy rates.

Shrinathan Esaki Muthu Pandara Kone
Kenichi Yatsugi
Yukio Mizuno
Hisahide Nakamura


Correction: Gender differential in low psychological health and low subjective well-being among older adults in India: With special focus on childless older adults

Ratna Patel
Strong P. Marbaniang
Shobhit Srivastava
Pradeep Kumar
Shekhar Chauhan
David Jean Simon


Genetic associations of adult height with risk of cardioembolic and other subtypes of ischemic stroke: A mendelian randomization study in multiple ancestries.

Abstract:
Background
Taller adult height is associated with lower risks of ischemic heart disease in mendelian randomization (MR) studies, but little is known about the causal relevance of height for different subtypes of ischemic stroke. The present study examined the causal relevance of height for different subtypes of ischemic stroke.
Methods and findings
Height-associated genetic variants (up to 2,337) from previous genome-wide association studies (GWASs) were used to construct genetic instruments in different ancestral populations. Two-sample MR approaches were used to examine the associations of genetically determined height with ischemic stroke and its subtypes (cardioembolic stroke, large-artery stroke, and small-vessel stroke) in multiple ancestries (the MEGASTROKE consortium, which included genome-wide studies of stroke and stroke subtypes: 60,341 ischemic stroke cases) supported by additional cases in individuals of white British ancestry (UK Biobank [UKB]: 4,055 cases) and Chinese ancestry (China Kadoorie Biobank [CKB]: 10,297 cases). The associations of genetically determined height with established cardiovascular and other risk factors were examined in 336,750 participants from UKB and 58,277 participants from CKB. In MEGASTROKE, genetically determined height was associated with a 4% lower risk (odds ratio [OR] 0.96; 95% confidence interval [CI] 0.94, 0.99; p = 0.007) of ischemic stroke per 1 standard deviation (SD) taller height, but this masked a much stronger positive association of height with cardioembolic stroke (13% higher risk, OR 1.13 [95% CI 1.07, 1.19], p < 0.001) and stronger inverse associations with large-artery stroke (11% lower risk, OR 0.89 [0.84, 0.95], p < 0.001) and small-vessel stroke (13% lower risk, OR 0.87 [0.83, 0.92], p < 0.001). The findings in both UKB and CKB were directionally concordant with those observed in MEGASTROKE, but did not reach statistical significance: For presumed cardioembolic stroke, the ORs were 1.08 (95% CI 0.86, 1.35; p = 0.53) in UKB and 1.20 (0.77, 1.85; p = 0.43) in CKB; for other subtypes of ischemic stroke in UKB, the OR was 0.97 (95% CI 0.90, 1.05; p = 0.49); and for other nonlacunar stroke and lacunar stroke in CKB, the ORs were 0.89 (0.80, 1.00; p = 0.06) and 0.99 (0.88, 1.12; p = 0.85), respectively. In addition, genetically determined height was also positively associated with atrial fibrillation (available only in UKB), and with lean body mass and lung function, and inversely associated with low-density lipoprotein (LDL) cholesterol in both British and Chinese ancestries. Limitations of this study include potential bias from assortative mating or pleiotropic effects of genetic variants and incomplete generalizability of genetic instruments to different populations.
Conclusions
The findings provide support for a causal association of taller adult height with higher risk of cardioembolic stroke and lower risk of other ischemic stroke subtypes in diverse ancestries. Further research is needed to understand the shared biological and physical pathways underlying the associations between height and stroke risks, which could identify potential targets for treatments to prevent stroke.

China Kadoorie Biobank Collaborative Group


Comportamiento clínico epidemiológico de la diabetes mellitus tipo 2 en edad pediátrica en Holguín

Abstract:
Introducción: La diabetes mellitus tipo 2 en edad pediátrica ha aumentado en los últimos años, constituyendo un problema emergente de salud pública.

Objetivo: Caracterizar el comportamiento clínico epidemiológico de la diabetes mellitus tipo 2 en edad pediátrica.

Método: Se realizó un estudio descriptivo de una serie de casos, en pacientes atendidos en el Hospital Pediátrico Provincial “Octavio de la Concepción de la Pedraja” de Holguín, Cuba, de enero del 2008 a diciembre del 2020. El universo lo integraron veintinueve niños y adolescentes con diabetes mellitus tipo 2.

Resultados: La prevalencia de diabetes mellitus tipo 2 ha aumentado en el último cuatrienio con una tasa de 13,2 por cada 100 000 habitantes, especialmente en adolescentes, con edad promedio de 10,7 ± 4,0 años. Los factores de riesgo principales son: sobrepeso, obesidad (79,3%) y antecedentes familiares de la enfermedad (69%). La mayoría de los pacientes no presentaban complicaciones, solo el 20,7% eran hipertensos al inicio de la enfermedad.

 El tratamiento más empleado fueron los antidiabéticos orales en el 75,8%, siendo más frecuente la metformina, en un 68,9%.

Conclusiones: La prevalencia de la diabetes mellitus en edad pediátrica, en ambos sexos, ha ido en incremento en la provincia, principalmente en adolescentes; se relaciona con factores de riesgo como el sobrepeso, la obesidad y los antecedentes familiares de primera y segunda línea. La mayoría de los pacientes no presentaba complicaciones y continúa siendo la metformina el medicamento de elección en este grupo etario.

Palabras clave: diabetes mellitus tipo 2, edad pediátrica, epidemiología, factores de riesgo

Jhonny Guarena Crespo
Martha Aleida Motes Velázquez

Universidad de Ciencias Médicas de Holguín


Knowledge and attitudes of nurses toward sickle cell disease patients in Jazan

Abstract: Background: In this study, we look at the role of nurses in dealing with sickle cell disease (SCD) patients in Jazan city. Objectives: The aim of this study was to determine the knowledge of nurses and their attitudes toward SCD patients in Jazan hospitals, Saudi Arabia. Materials and Methods: In this cross-sectional, hospital-based study, based on the inclusion and exclusion criteria, we recruited 240 nurses from Prince Mohammed bin Nasser and Jazan general hospitals in Jazan city, Saudi Arabia. We depend on the validity and reliability of the instrument that were done by the author who prepared the tool of the primary research, and data management processing was incorporated. Statistical analysis was performed with the obtained data. Results: In this study, 24.2% of males and 75.8% of females were included. Of these, 40.4% of nurses between 35 and 40 years of age. About 50.4% has 10–15 years of working experience. 5% of the study participants' salary is equal to 5000 SR which is the lower salary in the group of the participants. Also, 54.6% of nurses had a bachelor's degree, 32.9% had a diploma, and only 12.5% had a master's degree. Approximately 65% of nurses were married. Around 52% of nurses knew that SCD patients should have daily intake of 3 l of liquid and 44% of them recommended pop, juice, and broth. Among the sociodemographic variables, gender and income source were associated with attitude and knowledge scales, whereas among nurses' groups, only marital status was associated (P < 0.05). Also, among the sociodemographic variables of nurses, There is statistically significant relation between the nurses' knowledge and attitude and the demographic characteristics such as income levels, marital status and experiences as revealed by P.vale <0.05. In this study, 72.5% of nurses had poor knowledge score levels and 27.5% had good knowledge. Conclusion: This study concludes that the average total knowledge score was 8.41 and only 27.5% of nurses had good knowledge about SCD in Jazan region. This study also suggests increasing educational interventions, which could aid in improving nurses' knowledge and attitudes toward SCD. It is recommended to conduct a similar study with a large number of professionals in order to generalize the findings.

Journal of Family Medicine and Primary Care


Analysis of the status and framework design of intelligentcoal mine auxiliary transportation system

Abstract: This paper introduces the development and application status of intelligent auxiliary transportation technology in open-pit coal mine and underground coal mines at home and abroad. The intelligent auxiliary transportation system of open-pit coal mine has realized the functions of unmanned driving, automatic loading, automatic unloading, active obstacle avoidance and intelligent dispatching of mining trucks in fixed sections. And the system has achieved good application results in engineering practice. At present, the auxiliary transportation intelligence of underground coal mine is still in the development stage of single machine intelligence of equipment. The intelligent auxiliary transportation system integrating vehicle scheduling, operation status monitoring, traffic command, material control and other functions has not yet been formed. The main problems of intelligent auxiliary transportation system in underground coal mine are analyzed. The underground positioning system has low precision and poor real-time performance. The dispatching system function lacks effective integration. The driving assistance system module is not perfect. The unmanned driving technology lags behind and the test conditions are lacking. Based on the relevant requirements of intelligent auxiliary transportation in Coal Mine Intelligent Construction Guide (2021 edition), this paper puts forward the overall goal of the construction of intelligent auxiliary transportation. According to the overall goal, the intelligent coal mine auxiliary transportation system framework is designed. ① Coding and centralized loading transportation of materials realizes the whole process information management and control of materials from storage, coding, loading, transportation, unloading and recycling. ② Automatic loading and unloading and automatic connection realizes the automatic transfer and connection of materials among rail locomotives, monorail cranes, trackless and other different auxiliary transportation modes. ③ Accurate positioning and intelligent navigation achieves accurate real-time positioning, route planning and real-time navigation of personnel and transportation equipment. ④ Intelligent vehicle dispatching realizes the functions of auxiliary transportation comprehensive information display, data transmission, status monitoring, dispatching command and health management. ⑤ Driving assistance system builds several intelligent subsystems, such as anti fatigue driving warning, 360° panoramic look around monitoring, collision prevention, traffic sign identification, auxiliary braking for downhill driving, adaptive lighting, etc. Driving assistance system improves the safety of locomotive operation. ⑥ The auxiliary operation robot realizes the robot automatic operation of underground auxiliary operation scenes. The auxiliary operation robot reduces the number of personnel and improves the overall automation level of auxiliary operation. ⑦ Unmanned driving realizes the normal unmanned driving operation of locomotives in underground coal mine. The research can provide reference for the construction and development of intelligent auxiliary transportation system.

CHANG Kai
LIU Zhigeng
YUAN Xiaoming
LI Yuan

Editorial Department of Industry and Mine Automation


Psychological Factors Associated with Fibromyalgia and the Areas of Psychological Intervention

Abstract: Fibromyalgia is a musculoskeletal pain syndrome characterized with the presence of sensitive points and widespread chronic pain and restricts one's daily life activities and decreases the quality of life. The etiology of fibromyalgia is unclear, but there are numerous hypotheses regarding the emergence and progression of the disease. Among these, the biopsychosocial model offers a holistic framework in which biological, psychological and social mechanisms play a role in the development of fibromyalgia. Since the etiology of the disease is not yet understood, effective methods for its treatment have not been found, thus, interventions aim to reduce the effect of fibromyalgia and increase psychological and physiological functionality. This article aims to examine the psyhcological intervention areas and methods for fibromyalgia patients. In the literature, it is concluded that pain avoidance beliefs and behaviors, self-efficacy, physical activity, sleep quality, self-compassion, emotional skills, coping strategies, personality, comorbid psychopathology are the factors related with the emergence of the disease, severity of pain, and adherence to treatment in fibromyalgia patients. In this context, Cognitive-Behavioral Therapy (CBT), physical exercises, sleep management Acceptance and Commitment Therapy (ACT), compassion focused psychotherapies, mindfulness based psychotherapies, emotion expression and emotion regulation techniques, and biofeedback are recommended as effective methods which can be included in the treatment plans of fibromyalgia patients. Moreover, considering the psychosocial factors in the assessment processes was essential to establish individualized treatment plans. In addition, the importance of multidisciplinary approaches in the treatment processes of fibromyalgia has been discussed within the framework of the biopsychosocial model.

Rumeysa Eda Kanık Tezcan
Özden Yalçınkaya Alkar


Needle-Arthroscopic Ankle Lateral Ligament Repair Using a Knotless Suture Anchor

Abstract: Category: Arthroscopy; Ankle; Arthroscopy; Sports Introduction/Purpose: Arthroscopic techniques have been increasingly used to repair the anterior talofibular ligament (ATFL) for lateral ankle instability, however there are still concerns on complications, such as nerve injury, iatrogenic cartilage damage and wound scar. Additionally, standard suture anchors can cause prominent knots. Recently, a novel needle-arthroscopic system (NanoScope TM ) has been introduced, with a 1.9-mm diameter arthroscope and semirigid frame, which can reduce conventional arthroscopic-related complications by minimizing the skin incisions and provide excellent visualization without ankle distraction due to its small and semirigid features. The purpose of this surgical technical note is to describe a new, very minimally invasive surgical technique for the ATFL repair using this needle-arthroscopy with a knotless suture anchor, which has the potential to reduce both conventional arthroscopic-related and knot-related complications. Methods: We have developed a novel surgical treatment of the ATFL repair for lateral ankle instability in a cadaveric model. The arthroscopic system (NanoScope TM , Arthrex, Naples, FL) is used during the procedures. The handpiece tube is 9.5-cm long, semi-rigid and has a 1.9-mm outer diameter. The scope's direction of view is 0°, with a 120° field of view. The patient is placed in a supine position and no distraction is applied to the ankle joint. Standard anteromedial and anterolateral portals are first used. An accessory anterolateral (AAL) portal is then created around 1.5 cm anterior to the tip of the fibula, of which the portal position is determined under the visualization through the anterolateral portal. Results: Almost all of the talar and tibial surfaces are reachable without distraction, due to its small and semirigid features. There is no difficulty problem obtaining proper visualization of the ATFL and the surrounding structures during the whole procedures, due to a wide 120°-field of view. The major steps of the procedure are (1) suture anchor insertion into the distal fibula through the AAL portal using a Knotless SutureTak Anchor (Arthrex), (2) penetration of suture string into the ATFL remnant using a Micro SutureLasso TM (Arthrex), (3) capture of the ATFL remnant using a suture-relay technique, (4) reattachment of the ATFL remnant by pulling out the passing wire without knot-tying, in the dorsiflexed ankle position (Figure). All skin-incisions are tiny and require only paper skin closures. This method requires neither blunt dissection of subcutaneous tissue to pass the suture nor knot-tying to reattach the ATFL. Conclusion: Our technique is a simple, feasible, and very minimally invasive anatomic repair of the ATFL for lateral ankle instability using a 1.9-mm diameter needle-arthroscopy with a knotless suture anchor. However, the long-term clinical results need to be evaluated in future studies.

Yoshiharu Shimozono MD
Hiromu Ito
Hayato Ryoki
Sayako Sakai
Shinichiro Ishie
Ishie Arai
Yutaka Kuroda
Shuichi Matsuda


The impact of globalization and climate change on Trichinella spp. epidemiology

Abstract: The main reservoir hosts of nematodes of the genus Trichinella are wild carnivores, although most human infections are caused by the consumption of pork. This group of zoonotic parasites completes the entire natural life cycle within the host organism. However, there is an important phase of the cycle that has only been highlighted in recent years and which concerns the permanence of the infecting larvae in the striated muscles of the host carcasses waiting to be ingested by a new host. To survive in this unique biological niche, Trichinella spp. larvae have developed an anaerobic metabolism for their survival in rotting carcasses and, for some species, a resistance to freezing for months or years in cold regions. Climate changes with increasingly temperatures and reduction of environmental humidity lower the survival time of larvae in host carcasses. In addition, environmental changes affect the biology and ecology of the main host species, reducing their number and age composition due to natural habitat fragmentation caused by increasing human settlements, extensive monocultures, increasing number of food animals, and reduction of trophic chains and biodiversity. All of these factors lead to a reduction in biological and environmental complexity that is the key to the natural host-parasite balance. In conclusion, Trichinella nematodes can be considered as an indicator of a health natural ecosystem.


The Algerian city is a space for protest movements: A study in the sociology of protest

Abstract: This study aims to provide a sociological view of the protest movements known to Algeria. And how the city streets turned in to a space for protest movements. In the first element, we discussed the urban policies and planning tools adopted by political actors in controlling the urban growth of cities. The relation of these policies to the economic and social transformations that Algerian society has known, Where we divided the study into three main historical stages, We explained at each stage the impact of urban policies on the society of the city, in the second element we studied the protest movements experienced in the streets of the Algerian city, where took three basic forms: identity protest movements, religious protest movements, and demanded protest movements, and we dealt with the specificity of each protest movement, In the third and last element, we touched on the popular protest movement: February 22, 2019, and illustrated the symbolism of the streets and public squares, the nature of the social groups that participated in this movement, and slogans that Filed by protesters.

Journal of Umm Al-Qura University for Social Sciences


Corrigendum to “Metabolic risk factors in first acute coronary syndrome (MERIFACS) study” [Indian Heart J 2022 Jul–Aug;74(4):275–281]

B Hygriv Rao
NS Rama Raju
CS Srinivasa Raju
Pushpraj Patel
Radhika Korabathina
Jeffrey Pradeep Raj
Mohammed Sadiq Azam
B Annaji Rao
Yerra Shivakumar
Jabir Abdullakutty
P Krishnam Raju

Diseases of the circulatory (Cardiovascular) system


Osteopenia in a young man associated with the use of tenofovir disoproxil fumarate

Abstract: Abstract Tenofovir disoproxil fumarate is a recommended first‐line therapy for patients with chronic hepatitis B, although the frequent Tenofovir disoproxil fumarate related adverse drug reactions are nephrotoxicity and bone toxicity. We described the case of a 21‐year‐old Han Chinese male patient with chronic hepatitis B with tenofovir disoproxil fumarate‐associated osteopenia. The patient presented osteopenia at the site of his femoral neck with bone mineral density 0.865g/cm2 (Z = −1.9) in January 2020. Nine months after switching to TAF, bone mineral density at left femoral neck improved to 0.978g/cm2 (Z = −1.0) in September 2020. Bone mineral density of this patients was normal in January 2021. This is the first report in very young man presenting tenofovir disoproxil fumarate‐associated osteopenia.


التعليم والتدريب التقني والمهني  من أجل إنعاش وإعادة إعمار سورية "دراسة حالة من المنظور السوري"

Abstract:
تعد إعادة بناء رأس المال الاجتماعي والبشري في سورية في مرحلة ما بعد الأزمة أكثر صعوبة من إعادة بناء الطوب والمباني الاسمنتية (Salmon et al، 2018). وتهدف هذه الدراسة إلى إلقاء الضوء على أهمية التعليم والتدريب التقني والمهني (TVET) كسلاح من أسلحة البناء الجماعي للتعافي بعد الأزمة في سورية. وتبحث في ضرورة تفعيل وتحديث نظام التعليم والتدريب التقني والمهني في سورية من أجل معالجة الآثار المدمرة لأزمة السنوات التسع في البلاد، إضافة إلى تلبية احتياجات القوى العاملة الماهرة لمرحلة إعادة البناء.

وتقترح الدراسة التعليم والتدريب التقني والمهني أداة فعالة للتكيف مع التغيير الجذري في سوق العمل المحلي، وكذلك البنية الاجتماعية. ويُبنى هذا الاقتراح على الدروس المستفادة من الدول الأخرى ذات التجارب المماثلة التي تؤيدها المنظمات الدولية المتخصصة المتعددة. واُختبر الاقتراح من خلال دراسة كمية عن طريق استخدام الاستكشاف الاستقصائي على طلاب الماجستير المهني في إدارة الأعمال MBA في الجامعة الافتراضية السورية الذين يمثلون المجتمع السوري، كما أنهم يعدون مشاركين في برنامج تعليم مهني غير أكاديمي، وتتألف عينة الدارسة من 80 مفردة اختيرت بشكل عشوائي.

وتتمثل النتيجة الرئيسية للدراسة في أنه يمكن استخدام التعليم والتدريب التقني والمهني أداة تنموية فعالة للحفاظ على السلام وتعزيزه في سورية. وتؤكد على الحاجة الملحة لتصميم استراتيجية وطنية للتعليم والتدريب التقني والمهني، مع مزيد من المراجعة للهيكل الحكومي الحاكم والبحث عن تمويل مبتكر أيضاً.

رزان كم الماز
د. مـجــد صـقــور

رزان كم الماز

مجلة جامعة دمشق للعلوم الاقتصادية و السياسية

Economics as a science
Political science


Effect of Addition of Fermented Soy Sauce on Quality Characteristics of Pork Patties during Refrigerated Storage

Abstract: This study aimed to determine whether fermented soy sauce has a mutually synergistic effect on the quality and storage properties of pork patties, and to investigate the effects on the availability and physicochemical properties of various taste ingredients of soy sauce, a traditional Korean food ingredient. The experimental groups were as follows: Control (−): No additives; Control (+): 0.1% ascorbic acid; T1: 1% fermented soy sauce; T2: 3% fermented soy sauce; T3: 5% fermented soy sauce. No significant difference was detected in moisture, protein, and fat among the various treatment groups; however, ash content and water holding capacity increased and texture properties improved with the concentration of fermented soy sauce. The addition of fermented soy sauce during refrigerated storage for 10 days showed a positive effect on the storage properties. The peroxide value, content of thiobarbituric acid reactive substances and total phenolics, and 2,2-diphenyl-1-picrylhydrazyl free radical scavenging activity differed significantly in pork patties with different treatments and storage intervals. The effect of fermented soy sauce on the overall quality and storage properties of pork patties during refrigerated storage is relatively unknown. These findings demonstrate that the addition of fermented soy sauce improves the quality properties and antioxidant activity of pork patties.

Yun-a Kim
Sanghun Park
Yunhwan Park
Gyutae Park
Sehyuk Oh
Jungseok Choi


Equity and efficiency of public hospitals’ health resource allocation in Guangdong Province, China

Abstract: Abstract Background To better meet people’s growing demand for medical and health services, 21 cities in Guangdong Province were involved in the reform of public hospitals in 2017. This paper evaluates the equity and efficiency of public hospitals’ health resource allocation in Guangdong Province and explores ways to change the current situation. Methods Data were collected from the Guangdong Health Statistical Yearbook 2016–2020 and Guangdong Statistical Yearbook 2017–2021. The Gini coefficient (G), Theil index (T), and health resource density index (HRDI) were used to measure the equity of health resource allocation. An improved three-stage DEA method was applied in efficiency evaluation. The entropy weight method was employed to calculate the weight of different indicators to obtain a comprehensive indicator representing the overall volume of health resources in each city. A two-dimensional matrix was drawn between the HRDI of the comprehensive indicator and efficiency and the per capita government financial subsidies and efficiency to observe the coordination of equity and efficiency across regions. Results From 2016 to 2020, the G of public hospital, bed, and health technician allocation by population remained below 0.2, while that by geographical area ranged from 0.4 to 0.6; the G of government financial subsidies by population was above 0.4, while that by geographical area was greater than 0.7. The results for T showed that inequality mainly comes from intraregional differences, and the Pearl River Delta contributes most to the overall differences. Although the HRDI of the Pearl River Delta is far greater than that of other regions, obvious differences exist across cities in the region. Only 38.1% of cities were found to be efficient in 2020. The Pearl River Delta was in the first quadrant, and the other three regions were in the third quadrant, accounting for a large proportion. Conclusion The equity of government financial subsidies allocation was the worst, and there were distinct regional differences in the geographical distribution of health resources. The development of healthcare within the Pearl River Delta was highly unbalanced. The development of healthcare was uneven between the Pearl River Delta, eastern, western, and mountainous regions. In addition, most cities in the eastern, western, and mountainous regions bore the dual pressures of relatively insufficient health resources and inefficiency.

Wanmin Su
Liulin Du
Yujun Fan
Peixi Wang

International Journal for Equity in Health


Hardy-Leindler-Type Inequalities via Conformable Delta Fractional Calculus

Abstract: In this article, some fractional Hardy-Leindler-type inequalities will be illustrated by utilizing the chain law, Hölder’s inequality, and integration by parts on fractional time scales. As a result of this, some classical integral inequalities will be obtained. Also, we would have a variety of well-known dynamic inequalities as special cases from our outcomes when α=1.

H. M. Rezk
Wedad Albalawi
H. A. Abd El-Hamid
Ahmed I. Saied
Omar Bazighifan
Mohamed S. Mohamed
M. Zakarya


PENERAPAN CUSTOMER RELATIONSHIP MANAGEMENT (CRM) PADA SISTEM INFORMASI PELAYANAN JASA METEOROLOGI BERBASIS WEB

Abstract:
Pelayanan jasa informasi meteorologi yang cepat, tepat akurat dan mudah dipahami merupakan salah satu tugas Stasiun Meteorologi (STAMET) Kelas I Maritim Serang. Namun berdasarkan wawancara dan observasi yang dilakukan, menunjukan bahwa pelayanan yang dilakukan belum efisien dan praktis karena pengguna jasa harus datang ke kantor untuk memperoleh data yang diinginkan. Selain itu petugas pelayanan masih mencatat transaksi dalam buku yang kemudian diketik kembali pada aplikasi Microsoft Word, dan mengalami kesulitan dalam mencari berkas yang akan diberikan kepada pengguna jasa. Penelitian ini bertujuan untuk membuat sistem yang dapat membantu tugas STAMET untuk meningkatkan pelayanan jasa meteorologi dengan menggunakan pendekatan Customer Relationship Management (CRM). Metode pengembangan yang digunakan yaitu model prototype dengan perancangan diagram Unified Modelling Language (UML). Sistem dibuat menggunakan Framework Codeigniter dengan Bahasa pemograman Hypertext Preprocessing (PHP) sebagai Server side Programing dan MySQL sebagai Database Server. Metode pengujian sistem yang digunakan adalah Blackbox. Hasil akhir yang diharapkan adalah sebuah sistem informasi pelayanan jasa meteorologi berbasis Web, yang dapat membantu pengguna jasa mendapatkan informasi meteorologi, mempermudah petugas dalam memberikan pelayanan jasa, pembuatan jadwal kunjungan atau pertemuan, mengajukan komplain pelayanan jasa, memberikan kritik dan saran serta mengukur kepuasan pengguna jasa terhadap pelayanan yang diberikan oleh petugas STAMET Kelas I Maritim Serang.

Kata Kunci: Customer Relationship Management (CRM), Pelayanan Jasa Meteorologi, Sistem

Imam Agustian  Nugraha
Vidilla  Rosalina
Suherman


Determinants and Outcomes of Mortality among Extremely Preterm Infants From a Tertiary Hospital in Thailand: 15-Year Experience

Abstract:
Objective: It remains unclear if changes in neonatal care have resulted in better outcomes for extremely preterm infants (EPTs). This study was to evaluate neonatal mortality and morbidity in EPTs.
Material and Methods: A retrospective cohort study of EPTs at a gestational age (GA) ≤28 weeks, who were admitted to the neonatal intensive care unit between January 2004 and December 2018. The study was divided into 2 periods, from 2004-2010 and 2011-2018. The likelihood ratio test in Multiple Cox regression models were used to determine adjusted hazard ratios (aHR) for differences in mortality among the two periods.
Results: A total of 188 EPTs were enrolled. The overall median (interquartile range), GA and birth weight of the enrolled infants were 26 (25, 27) weeks and 780 (667, 875) g, respectively. The mortality rate was 66/188 (35.1%). The mortality rate between 2004-2010 and 2011-2018 decreased from 44.6% to 32.8%, but was not statistically significant (p-value=0.170). Multiple Cox regression analysis of mortality rate demonstrated statistical significance with infants of 23-24 and 25-26 weeks GA VS 27-28 weeks GA [aHR 3.85, 95% confidence interval (CI) (1.95, 7.58), p-value<0.010] and [aHR 1.92, 95% CI (1.09, 3.35), p-value<0.010], respectively. Pregnancy complications [aHR 2.24, 95% CI (0.96, 5.24), p-value=0.040)] and EPTs intubated VS early CPAP at birth [aHR 2.41, 95% CI (1.36, 4.25), p-value<0.010] were statistically significant.
Conclusion: The mortality rate of EPTs decreased with advancing GA. Prenatal care of pregnancy complications and improving care practices might reduce the mortality rate.

Waricha Janjindamai
Anucha Thatrimontrichai
Supaporn Disneevate
Gunlawadee Maneenil

Journal of Health Science and Medical Research (JHSMR)


The Functional Role of Long Non-Coding RNA in Myogenesis and Skeletal Muscle Atrophy

Abstract: Skeletal muscle is a pivotal organ in humans that maintains locomotion and homeostasis. Muscle atrophy caused by sarcopenia and cachexia, which results in reduced muscle mass and impaired skeletal muscle function, is a serious health condition that decreases life longevity in humans. Recent studies have revealed the molecular mechanisms by which long non-coding RNAs (lncRNAs) regulate skeletal muscle mass and function through transcriptional regulation, fiber-type switching, and skeletal muscle cell proliferation. In addition, lncRNAs function as natural inhibitors of microRNAs and induce muscle hypertrophy or atrophy. Intriguingly, muscle atrophy modifies the expression of thousands of lncRNAs. Therefore, although their exact functions have not yet been fully elucidated, various novel lncRNAs associated with muscle atrophy have been identified. Here, we comprehensively review recent knowledge on the regulatory roles of lncRNAs in skeletal muscle atrophy. In addition, we discuss the issues and possibilities of targeting lncRNAs as a treatment for skeletal muscle atrophy and muscle wasting disorders in humans.

Keisuke Hitachi
Masahiko Honda
Kunihiro Tsuchida


Genome-wide association studies for the identification of cattle susceptible and resilient to paratuberculosis

Abstract: Mycobacterium avium subsp. paratuberculosis (MAP) causes Johne's disease or paratuberculosis (PTB), with important animal health and economic implications. There are no therapeutic strategies to control this disease, and vaccination with inactivated vaccines is limited in many countries because it can interfere with the intradermal test used for bovine tuberculosis detection. Thus, infected animals either get culled after a positive ELISA or fecal PCR result or die due to clinical disease. In this study, we review recent studies aimed to discover genetic markers which could help to identify and select cattle less susceptible and more resilient to PTB. In recent years, the genotyping and subsequent imputation to whole-genome sequence (WGS) has allowed the identification of single-nucleotide polymorphisms (SNPs), quantitative trait loci (QTL), and candidate genes in the Bos taurus genome associated with susceptibility to MAP infection. In most of these genome-wide association studies (GWAS), phenotypes were based on ante-mortem test results including serum ELISA, milk ELISA, and detection of MAP by fecal PCR and bacteriological culture. Cattle infected with MAP display lesions with distinct severity but the associations between host genetics and PTB-associated pathology had not been explored until very recently. On the contrary, the understanding of the mechanisms and genetic loci influencing pathogen resistance, and disease tolerance in asymptomatic individuals is currently very limited. The identification of long-time asymptomatic cattle that is able to resist the infection and/or tolerate the disease without having their health and milk production compromised is important for disease control and breeding purposes.

Marta Alonso-Hearn
Gerard Badia-Bringué
Maria Canive


Book review

Journal of Indentureship and its Legacies

Colonies and colonization. Emigration and immigration. International migration


Maternal Mood and Perception of Infant Temperament at Three Months Predict Depressive Symptoms Scores in Mothers of Preterm Infants at Six Months

Abstract: Postpartum depression is more prevalent in mothers and fathers of preterm infants compared to parents of full-term infants and may have long-term detrimental consequences for parental mental health and child development. The temperamental profile of an infant has been postulated as one of the important factors associated with parental depressiveness in the first months postpartum. This study aimed to examine the longitudinal relationship between depressive symptoms and perceived infant temperament at 3 months corrected age, and depressive symptoms at 6 months corrected age among mothers and fathers of infants born preterm. We assessed 59 families with infants born before the 34th gestational week using the Edinburgh Postnatal Depression Scale (EDPS) and the Infant Behavior Questionnaire-Revised. We found that mothers’ scores on EPDS and infants’ Orienting/regulation at 3 months corrected age predicted mothers’ EPDS scores at 6 months corrected age. In particular, higher depressive scores were related to higher depressive symptoms at 6 months corrected age, whereas higher infant Orienting/regulation was related to lower depressive symptoms at 6 months corrected age. Due to the low internal consistency of EPDS at 6 months for fathers, we were unable to conduct similar analyses for fathers. Our results point to the importance of considering both early indices of maternal mood as well as mother-reported measures of preterm infant temperament in the attempts to predict levels of maternal depressiveness in later months of an infant’s life. Further studies are urgently needed in order to better understand the associations between depressiveness and infant temperament in fathers, and with more consideration for the severity of the effects of infant prematurity.

Grazyna Kmita
Grazyna Kmita
Eliza Kiepura
Alicja Niedźwiecka


Quantitative calculation method of development indexes for layered and directional of production wells(生产井开发指标的分层分方向定量计算方法)

Abstract: 针对注水开发的多层砂岩油藏分层动态分析难度大等问题，在常规井层开发指标计算基础上，结合动、静态劈分方法，综合考虑渗透率、孔隙度、地层系数、含水饱和度、位置系数、措施系数及注水量系数，提出了一种既可将油、水井作为统一整体，又可对小层、方向流动分量开发指标进行定量计算的体现渗流力学本质的方法。用大庆油田N2-O1井组的产液剖面资料进行验证。结果表明，所提方法的计算结果与测量结果吻合度较高，精度平均值达75.11%。用该方法计算开发指标，适用性强，能较真实地反映各小层、各方向的产液情况，对现场应用具有指导意义。

ZHANGJicheng(张继成) RENShuai(任帅) LINLi(林立) ZHAOShuai(赵帅) FENGShimiao(冯诗淼)

Electronic computers. Computer science
Physics


Specificity and current trends in the digital advertising development

Abstract: The digital advertising development features and prospects in the world and in the Russian Federation in particular have been considered. An approach to defining the advertising concept essence in the digital field has been presented. A summary of the scientific research results has made it possible to identify the industry’s growth constraints and its main development drivers, as well as define the importance and distinguishing features of modern advertising campaigns in the digital space. Based on analysis of current data from relevant organisations for the digital advertising market, an increase in growth rates has been identified overall by region and country, as well as for individual advertising segments.

Вестник университета

Sociology (General)
Economics as a science


Editorial: Optical imaging and neurorehabilitation strategies after stroke

Anna-Sophia Wahl
Anna-Sophia Wahl
Adam Q. Bauer
Adam Q. Bauer
Anna Letizia Allegra Mascaro
Anna Letizia Allegra Mascaro

Neurosciences. Biological psychiatry. Neuropsychiatry


Fishing, predation, and temperature drive herring decline in a large marine ecosystem

Abstract: Abstract Since 1960, landings of Atlantic herring have been the greatest of any marine species in Canada, surpassing Atlantic cod and accounting for 24% of the total seafood harvested in Atlantic Canada. The Scotian Shelf‐Bay of Fundy herring fisheries (NAFO Division 4VWX) is among Canada's oldest and drives this productivity, accounting for up to 75% of the total herring catch in some years. The stocks’ productivity and overall health have declined since 1965. Despite management measures to promote recovery implemented since 2003, biomass remains low and is declining. The factors that drive the productivity of 4VWX herring are primarily unresolved, likely impeding the effectiveness of management actions on this stock. We evaluated potential drivers of herring variability by analyzing 52 time‐series that describe the temporal and spatial evolution of the 4VWX herring population and the physical, ecological, and anthropogenic factors that could affect them using structural equation models. Variation in herring biomass was best accounted for by the exploitation rate's negative effect and the geographic distribution of fishing and recruitment. Thermal phenology and temperature adversely and egg predation positively impacted the early life stage mortality rate and, ultimately, adult biomass. These findings are broadly relevant to fisheries management, but particularly for 4VWX herring, where the current management approach does not consider their early life stage dynamics or assess them within the ecosystem or climate change contexts.

Daniel G. Boyce
Brian Petrie
Kenneth T. Frank


β-D-galactopyranoside Seco-phytoporphyrin from Atropa Belladonna and Solanum Tuberosum Yellow Leaves Determined by Nuclear Magnetic Resonance

Abstract: The study described the isolation of β-D-galactopyranoside seco-phytoporphyrin from Atropa belladonna and Solanum tuberosum yellow leaves. Column chromatography was applied for its isolation. The UV-Vis, mass spectrometry and NMR spectroscopy were used for the structure confirmation. The results demonstrate that the two plants that the same chlorophyll catabolite structure.

Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry

Academy of Sciences of Moldova, Institute of Chemistry