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skip113
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bmc_original_1M

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Effect of imprinting temperature on formation of nanoporous (left); (a) 120℃, (b) 140 ℃, (c) 160 ℃, (d) 140 ℃, and (e) PS1/PVA melt droplets on AAO surfaces (right).
PMC6630784_polymers-11-01039-g007
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
SEM images of the glass surface coated in aqueous anatase (TiO2) solution at pH 2 under vigorous stirring for 80 min (×90000). (a) Point EDS analysis of the glass surface. (b).
PMC6526232_gr8
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
SEM micrograph of Hydrogum 5 alginate impression material; original magnification 1.200x.
PMC4131559_BMRI2014-178064p008
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Whole‐brain analyses show positive and inverse relationships between self‐reported navigation ability and optic flow‐sensitive region functional connectivity strength during turn counting. Effect maps (left and top right) and summary map (bottom right) showing where the functional connectivity patterns of OF‐sensitive regions during TC were positively and inversely associated with SBSoD score (Z threshold 2.3). Warm colors represent a positive association; (top) stronger connectivity between OF‐sensitive regions (L CSv, R CSv) and warm‐colored areas during TC relative to rest was associated with better self‐reported navigation ability (higher SBSoD scores). (bottom right) The maximum overlap of where OF‐sensitive region functional connectivity was positively associated with SBSoD score was 2, which can be seen in a number of areas in the summary map. Blue regions represent the inverse association found; (bottom) stronger connectivity between the OF‐sensitive region R pVIP and cool‐colored areas during TC relative to rest was associated with worse self‐reported navigation ability (lower SBSoD scores). Maps are displayed on the MNI152 T1 2 mm template, and x, y, and z slices correspond to this template. For more detailed information on the strength and statistical significance of the relationships shown in these figures, see Table 3. FC: functional connectivity; Hipp: hippocampus; L: left; L CSv: left cingulate sulcus visual area; MNI: Montreal Neurological Institute; OF: optic flow; R: right; R CSv: right cingulate sulcus visual area; ROI: region of interest; RSC: retrosplenial cortex; SBSoD: Santa Barbara Sense of Direction; TC: turn counting
PMC6456774_BRB3-9-e01236-g005
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Abduction defect of the left eye.
PMC10123313_CCR3-11-e7268-g003
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
CT control scan of VB (sagittal)
PMC5086345_381_2016_3250_Fig7_HTML
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
ER and actin filaments interaction during plasmolysis in Arabidopsis. A) Actin formation at different focal planes (lower left) of a plasmolyzed hypocotyl cell with a 3D reconstruction showing several Hechtian strands, one of which is labeled HS. Regions containing the Hechtian reticulum as identified with DIC are shown as HR. B–D) Confocal images of hypocotyl cells showing the separate green channel with actin filaments labeled with YFP-ABD2, the red channel showing the ER labeled with mCherry-HDEL, and a merged image. B) ER tracks on actin within the protoplast during plasmolysis. The outline of the protoplast is in cyan. C) Actin doesn’t show up in the Hechtian reticulum outlined in cyan. D) Actin forms a big Hechtian strand within the periplasmic region, labeled HS, but is excluded in the fine network of the Hechtian reticulum, labelled HR. Adj. cell, adjacent cell. Scale bar, 10 μm.
PMC5853952_erx24307
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Versican and ALP expression in the presence of soluble factors. Versican: immunocytochemistry, fluorescent microscopy, scale bare 200 μm. ALP: histochemistry, bright field microscopy, scale bare 500 μm.
PMC5654293_SCI2017-9271869p006
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Immunocytological staining of IPEC‐J2 cells on filter membranes with antibodies raised against ZO‐1 (green) and claudin‐1 (red) after 24 h of incubation with berberine. Nuclei were stained with DAPI (blue). Under control conditions, both proteins were detected in the lateral membrane; the yellow signal in the overlay shows co‐localization. The signal for ZO‐1 was also located next to cell‐cell contacts for all concentrations, while the signal for claudin‐1 was detected more intracellularly than in the TJs of the 100 µM and the 200 µM groups. In addition, the ZO‐1 signal appears weaker with increasing berberine concentrations. The area circled by white dots shows a hole inside of the monolayer (scale bar: 20 µM, n = 4, representative images)
PMC8981188_PHY2-10-e15237-g007
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
A–C Role of FcRn on recycling and degradation of pathogenic IgG antibody levels (A, B) and effect of FcRn heterozygosity (C) on sustainability of infused IVIg. A Normally, IgG antibodies (Y in red) bind to FcRn (light-blue receptors) to return, via the endocytotic vesicles, intact back into the circulation being protected by FcRn from degradation in the lysosomes. B The supra-physiological IgG levels from the infused IVIg (Y in blue) partially saturate the FcRn (saturated receptors depicted in red dots) leading to degradation of the endogenous IgG antibodies in the lysosomes, instead of being recycled back to the surface (degraded Y in red), resulting in reduced circulating IgG antibody levels. C The FcRn in heterozygous VNTR2/3 patients (depicted with red dots on the light-blue FcRn receptors) may not be fully effective in saturating FcRn and protecting the infused IVIg from degradation; as result, part of the infused IgG is degraded in the lysosomes instead of fully returning back into the circulation (degraded Y in blue). In heterozygous VNTR2/3 patients therefore, the IgG serum level from the infused IVIg does not increase as much as in homozygous VNTR3/3 individuals who have fully functioning FcRn, resulting in lower immunomodulatory effect of IVIg and lesser reduction of the pathogenic antibodies; higher IVIg dose to compensate for its catabolism is perhaps needed for the VNTR2/3 heterozygotes (adapted from [37])
PMC8585501_13311_2021_1108_Fig3_HTML
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Mechanism of kaempferol suppressing proliferation in gynaecological malignancies.
PMC10748757_fphar-14-1310416-g002
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Magnetic resonance imaging of the pygopagus twins; they shared the sacrum, coccyx, anus, and urethra. Each had a separate bladder
PMC7788156_40981_2020_406_Fig1_HTML
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Reconstructed 3D subcellular tomography of Candida rugosa. Yellow arrow: cytoplasm, pink arrow: cell wall, violet arrow: nucleus, red arrow: vacuole, green arrow: mitochondria, (visualization 3, visualization 4).
PMC5899089_41598_2018_24408_Fig6_HTML
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
(A) Bone scintigraphy (anterior and posterior) demonstrated avid radiotracer uptake in the T11 vertebral body (arrow). (B) Axial CT imaging identified bone destruction at T11 with partial cortical breach and an adjoining paravertebral soft tissue mass that contributed to spinal canal stenosis. (C) Lateral radiograph of the spine demonstrated osteolytic damage and collapse of the T11 vertebral body (arrow). (D–G) 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT showed extensive destruction of the T11 vertebral body (thin arrow) and intense FDG uptake (maximum standardized uptake value of 8.8) in the surrounding soft tissue (thick arrows) [(D), MIP image; (E), CT; (F), PET; and (G), fusion].
PMC10884278_fonc-14-1294772-g002
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Rho activity is required for the assembly of tangential and radial AJs.Cell monolayers were wounded in the presence of C3 transferase and TRITC-labeled dextran (as a marker). Cells were fixed and stained for E-cadherin or N-cadherin. In control cultures, AJs are formed at the sites of cell-cell contacts (arrows). The IAR-2, IAR-6-1, and IAR1170 cells loaded with C3 are unable to assemble new AJs (arrowheads). Bar, 10 µm.
PMC2779654_ponep0008027pg007
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
HFD effect on BBB integrity in the striatum of sham, moderate, and severe lesion groups. A Confocal images showing plasma protein leakage (green) (fibrinogen left panel and IgG right panel) in sham, moderate, and severe lesion groups fed with either CTRL diet or HFD. B, C Corresponding quantification of extravascular fibrinogen and IgG, respectively. Data are expressed in sqrt % of leakage fraction area of the total image area. Sham (CTRL diet: n = 5, HFD: n = 4), moderate lesion mice (CTRL diet: n = 3, HFD: n = 3), and severe lesion mice (CTRL diet: n = 6, HFD: n = 4). Two-way ANOVA: *p < 0.05, **p < 0.01. Scale bar 50 μm. IgG immunoglobulin G
PMC8353816_12974_2021_2218_Fig7_HTML
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Examples of the concordant groups (A and B) where there is agreement between the visual rating and all three meta-ROIs while the discordant groups (C and D) have disagreement visually and with all three meta-ROIs. While the meta-ROI can miss visually positive scans where the SUVR is lower than the cutoff point (C), the visual assessment does not consider isolated increased activity in the MTL (D). The red arrows indicate where there is increased tracer uptake activity.
PMC10602128_nihpp-rs3290598v1-f0004
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
PXDN mutant mice reveal impairment in bacterial clearance during acute lung infection.(A) Decrease of relative survival rates. PXDN-deficient and C57BL/6 wild-type mice were intratracheally instilled with 7 x 106 of P. aeruginosa strain K or PBS control. Relative survival rates were determined over a period of 48 hours; n = 9–11 per group, P = 0.0068. (B) Lung Bacterial burden. Mice were sacrificed at 20 hours; lungs were aseptically removed, weighed, and homogenized in PBS. Lung tissue suspension was serially diluted and plated on LB agar plates. After incubation at 37°C for 18 h, CFUs were counted and CFUs/mg tissue were calculated; n = 12 from 4 mice per group; one-way analysis of variance, P < 0.0001 for all comparisons. (C and D) Tissue burden on bacterial infection with sublethal dose was carried out by intratracheally infecting the mice with 3 x 106 of P. aeruginosa strain K. After 20 h, lung, liver and spleen were taken as in (B) for detection of bacteria. n = 15–21 from 5–7 mice per group; P (lung) = 0.016; P (liver) = 0.843; P (spleen) = 0.014. (E) H&E staining of the lungs from uninfected and infected mice. Mice were infected as in (C) and the lungs were harvested at 20 h for preparation of staining. a. WT mouse, uninfected; b, WT mouse, infected; c. PXDN-deficient mouse, uninfected; d, PXDN-deficient mouse, infected. Magnification: 400x. Scale: 5μm.
PMC5979044_ppatp1007026pg005
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Grad-CAM images of correct male height predictions. (a) VGG16, correct prediction for tall. (b) Inception-v3, correct prediction for tall. (c) Resnet50, correct prediction for tall. (d) VGG16, correct prediction for short. (e) Inception-v3, correct prediction for short. (f) Resnet50, correct prediction for short.
PMC9029985_entropy-24-00475-g007
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
T1-weighted (a) and T2-weighted (b) MR images of bladder at different time points following injection of ultrasmall Fe3O4 nanoparticles. Temporal evolution of MR signals of the bladder for T1-weighted (c) and T2-weighted (d) imaging. (e) Quantification of Fe content in urine using ICP-OES. (f) Quantification of Fe3O4 nanoparticle internalization in RAW264.7 macrophages with different surface modifications
PMC11089712_12951_2024_2516_Fig3_HTML
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Chest computed tomography scan showed the presence of subcutaneous emphysema (*), pneumothorax (**), and necrotizing pneumonia with empyema (arrows) (Part a). After chest drainage placement (*), computed tomography scan showed the persistence of loculated pneumothorax (**) (Part b). Despite the insertion of chest tube (*), right lower lobe did not expand as it was trapped by pleural adhesions (arrows) (Part c). Following closure of alveolar pleura fistula, chest computed tomography showed no progression of loculated pneumothorax (*) (Part d)
PMC6751653_13019_2019_987_Fig1_HTML
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
SEM images of copper-coated on PPC surface with different Cu2+ concentration (a) uncoated surface (b) 0.04 mol L−1 (c) 0.06 mol L−1 (d) 0.08 mol L−1.
PMC9055134_d0ra00461h-f12
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
A 56-year-old male patient with allogeneic ACL reconstruction.
PMC8940546_CIN2022-8256450p007
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Destruction by ethyl pyruvate of biofilms prepared under dynamic fluid condition.(a) Colony forming units derivable from biofilms before and after treatment with ethyl pyruvate (EP) in silicone tubes. (b) Treatment of matured biofilms in silicone tubes by 50 mM EP and 50 mM ethyl lactate (EL) as well as Penicillin/Streptomycin (0.28/0.17 mM) as a control. Destruction of biofilm in the presence of antibacterial compounds was evaluated at different time intervals. Scanning electron microscopy clearly shows well-structured matured biofilm, containing microorganisms encased in extracellular matrix (c, d). EP treatment (50mM) displays few cells, cell debris and dissolution of extracellular matrix (e, f). Representative profile of MALDI-TOF mass spectrum of the identified Sphingomonas paucimobilis from the silicone tube biofilm (g).
PMC5033407_ponep0162919pg005
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Exemplary diagnoses of recent small subcortical infarct, transient global amnesia, Creutzfeldt-Jakob disease, encephalitis and lymphoma made on diffusion-weighted imaging.(a) A 62 year old man with memory impairment since one year ago was subsequently diagnosed with vascular dementia. Axial diffusion-weighted image (left, b value = 1000 sec/mm2, slice thickness/gap, 2/0 mm) showed a tiny diffusion restricted lesion in the right paracentral lobule suggesting a recent small subcortical infarct (arrow). There was hyperintensity in the corresponding area (arrow) on the axial fluid-attenuated inversion recovery image (right), which was indistinguishable from white matter hyperintensity due to severe small vessel disease. (b) A 50 year old man with a history of transient memory impairment was subsequently diagnosed with transient global amnesia. Axial, diffusion-weighted image (left, b value = 1000 sec/mm2, slice thickness/gap, 2/0 mm) showed a tiny diffusion restricted lesion in the right hippocampus (arrow). This lesion was not demonstrable in the corresponding area (arrow) on the axial fluid-attenuated inversion recovery image (right). (c) A 63 year old woman who presented with rapidly progressive memory decline was subsequently diagnosed with Creutzfeldt-Jakob disease. Axial, diffusion-weighted image (left, b value = 1000 sec/mm2, slice thickness/gap, 2/0 mm) showed diffuse cortical diffusion restriction in bilateral parietal lobes (arrows) with subtle hyperintensity in the corresponding area (arrows) on the axial fluid-attenuated inversion recovery image (right). (d) A 50 year old woman who reported memory impairment following bone marrow transplantation for myelodysplastic syndrome was subsequently diagnosed as encephalitis on multidisciplinary consensus. Axial diffusion-weighted image (left, b value = 1000 sec/mm2, slice thickness/gap, 2/0 mm) showed diffusion restriction in bilateral medial temporal lobes (arrows), with subtle hyperintensity in the corresponding area (arrows) on the axial fluid-attenuated inversion recovery image (right). (e) A 75 year old man who presented with progressive memory impairment was subsequently diagnosed as diffuse large B cell lymphoma on stereotactic biopsy. Axial diffusion-weighted image (left, b value = 1000 sec/mm2, slice thickness/gap, 2/0 mm) showed diffusion restriction associated with a mass-like lesion involving the splenium of the corpus callosum that was hyperintense with perilesional edema on the axial fluid-attenuated inversion recovery image (right).
PMC9498979_ponep0274795pg002
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Patient's plain radiographs of the left wrist.
PMC4993032_eplasty16ic34_fig1
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Plasma membrane repair is defective in S100A11-KO EA.hy926 cells. (A) Representative images of FM4-64 influx following membrane damage in S100A11-KO, clone #1 and #3, or WT EA.hy926 cells (see Supplementary videos S1, S3). Cells kept in Tyrode’s buffer supplemented with 2.5 mM Ca2+ and 5 μg/ml FM4-64 were injured by laser ablation at 820 nm (near infrared) directed at the plasma membrane on the lateral edge (white triangles represent the wound sites). Wounding occurred at t = 0; pre-wounding and post-wounding time points are shown. Calibration bar of fluorescence intensity is provided in the upper right panel. Scale bars = 10 µm. (B) Time course of whole-cell FM4-64 fluorescence normalized to fluorescence before injury in WT (left) or S100A11-KO cells (clone #1: middle and clone #3: right) laser-ablated in the presence of extracellular Ca2+ or EGTA. (C) AUC values of FM4-64 fluorescence in WT or S100A11-KO cells damaged in the presence of extracellular Ca2+. S100A11-KO, n = 27 cells per clone; WT, n = 18 cells. Results were pooled from three independent experiments. Statistical analysis was performed with ordinary one-way ANOVA. (D) Exemplary fields of mechanically wounded WT or S100A11-KO cells stained with FITC-Dextran, TRITC-Dextran and Hoechst. The protocol (see Materials and Methods) permits the distinction between wounded and repaired cells (that had taken up only FITC-Dextran) and wounded but non-repaired cells (that had taken up FITC-Dextran and TRITC-Dextran). Hoechst was included as a marker for all cells. Scale bars = 50 μm. Quantification of non-repaired WT or S100A11-KO cells, represented as a percentage of total wounded cells (right). Results were pooled from three independent experiments (n = 75 fields). Statistical analysis was carried with two-tailed Student’s t test. Data are mean ± SD.
PMC9527316_fcell-10-968164-g001
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Papillary fibroelastomaImage Credit: Tyabelly et al., 2020 [33]; Licensed under CC-BY
PMC10831205_cureus-0016-00000051488-i04
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
PTFE 6 mm graft showing the anastomosis between the right common carotid and the right subclavian arteryPTFE - polytetrafluoroethylene
PMC9525152_cureus-0014-00000028648-i03
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
External Morphology of crystal RF2. (a–d) 85 × 85 × 85 nm voxel size phase reconstruction. Apatite inclusions are highlighted in green, Fe-rich particles are in red, Zn refers to the Zn-bearing particle highlighted in Fig. S2c. Images in (a–d) are related by 90° rotation. The image in (a) can be compared with the SE image and EDX chemical map in Fig. S2c-d.
PMC10907758_41598_2024_55846_Fig3_HTML
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Two-photon calcium imaging reveals response latency decrease and direction selectivity improvement of the reprogrammed neurons over time. (A) Injection scheme for two-photon calcium imaging. ET-1 was first injected to induce a focal stroke. 7 days after ET-1 injection, AAV-GFAP::Cre, AAV-FLEX-NeuroD1-mCherry, and AAV-FLEX-GCaMP6s were injected in the same sites. Reprogrammed cell activities in awake mice were imaged by a two-photon microscope at 3 and 6 weeks after viral injection (at the age of 3-3.5 months old). For the healthy control, AAV-syn-jGCaMP7s was injected into mouse V1, and cell activities were imaged at 3-4 weeks post-injection (at the age of 2.5 months old). (B) NeuroD1 and GCaMP6s signals were well overlapped. Well isolated ROIs were chosen for further analysis. Scale bar represents 50 μm. (C) Trial-averaged traces of representative cells showed selective responses to 12 directions. Shaded areas represent visual stimulation. (D) The cumulative density of visually evoked response latencies of cells at 3 and 6 weeks after viral injection, compared with cells in healthy control mice. Quantification of latencies shown in the inset. N3 week = 187 ROIs from 3 mice, N3 week = 181 ROIs from 5 mice, N6 week = 375 ROIs from 5 mice. 3 week vs. 6 week: p = 0.023; 3 week vs. Healthy: p = 0.001; 6 week vs. Healthy: p = 0.045, One-way ANOVA followed by Tukey post hoc tests. (E) Cumulative density curves of 1-CV of the reprogrammed cells at 3 and 6 weeks after viral injection. Quantification of 1-CV shown in the inset. 3 week vs. 6 week: p = 0.001; 3 week vs. Healthy: p = 0.392; 6 week vs. Healthy: p = 0.005, One-way ANOVA followed by Tukey post hoc tests. (F) Same as (E) but for 1-DCV. Quantification of 1-DCV shown in the inset. 3 vs. 6 week: p = 0.001; 3 week vs. Healthy: p = 0.341; 6 week vs. Healthy: p = 0.036, One-way ANOVA followed by Tukey post hoc tests. *p < 0.05, **p < 0.01, and n.s., not significant. Data are represented as mean ± SEM.
PMC8416524_fcell-09-720078-g007
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Cerebellum. A cerebellar ROI was identified by contrasting pre-exercise > post-exercise activity derived from the 2-Back > 0-Back condition in the GWI group (cluster-level P = 0.0028, FWE, kE = 396). (A) Sagittal (top), coronal (middle) and transverse (bottom) slices of an MNI-standard brain, where crosshairs indicate the cluster’s most active voxel (10, −44, -22). (B) BOLD response for the 2-Back > 0-Back condition (mean ± SEM) are shown for pre-exercise (top) and post-exercise (middle). ΔBOLD (bottom) is the post-minus pre-exercise BOLD response for the 2-Back > 0-Back condition for the control (black bars), GWI (white bars) and ME/CFS (grey bars). Error bars represent 95% CI.
PMC7425336_fcaa070f2
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Nodo-ventricular and fasciculo-ventricular pathways: Both sections were taken from human hearts shown at autopsy to exhibit Ebstein’s malformation. (A) shows a direct nodoventricular connection between the inferior rightward extention of the atrioventricular (AV) node and the crest of the ventricular septum, while (B) shows a fasciculo-ventricular connection given off from the conduction axis prior to the origin of the right bundle branch. The sections were stained using the trichrome technique.
PMC7832324_jcdd-08-00005-g004
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
CT scan performed at 6-month follow-up. The arrows show dorsal bone spur.
PMC5851171_CRIOR2018-8351205p003
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Immunohistochemical staining of c-fos expression in the lung adenocarcinoma tissues. c-fos showed nuclear staining pattern.
PMC3639873_1749-8090-8-95-2
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Photomicrograph of the bursa of Fabricius of control (A) and clenbuterol treated groups of chickens; (B) clenbuterol 10 ppm, (C) clenbuterol 15 ppm and (D) clenbuterol 20 ppm showing pseudostratified columnar epithelium (E), lamina propria (P), cortex (C) and medulla (M) of lymphoid follicle separated by undifferentiated cell layer (U). Stain H&E, scale bar = 50µm. E. morphometric analysis of total cell count of lymphoid follicles of the bursa of Fabricius. Columns with differ superscripts (a, b, c, d) differ significantly (p < 0.05).
PMC8388663_animals-11-02429-g005
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Decreased CD151 expression promoted coronary blood flow and mature angiogenesis.(a) Representative images of Pulsed-wave (PW) Doppler of LCA at baseline or under hyperemic conditions induced by inhalation of 1% or 2.5% isoflurane, respectively. CFR is calculated as the ratio of hyperemic peak diastolic flow velocity to baseline peak diastolic flow velocity (n≥6). (b) Colocalization of fibroblast marker col1α1 and endothelial marker CD31 in control and TAC-induced HF heart sections with different treatments (left), quantified by Image J (right). Data are expressed as mean ± SEM.
PMC10863850_ponep0297121pg002
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Representative photographs of augmented reality microscopy during lateral skull base surgery. A, Left TS and SS visualized using augmented reality microscopy. Following intravenous injection of ICG, the vessel fluoresced and was visualized with surrounding anatomy. B, Visualization of AICA and TF implant adjacent to the vestibulocochlear-facial nerve complex (CN 7/8) using augmented reality microscopy following decompression. C–E, Visualization of facial nerve and AICA loop adjacent to CN 7/8 before (C) and after ICG injection (D), and after decompression (E) using augmented reality microscopy. Additional compression also noted inferior to dorsal root entry zone. AICA indicates anterior inferior cerebellar artery; ICG, indocyanine green; SS, sigmoid sinus; TF, teflon; TS, transverse sinus.
PMC10969557_ono-1-e004-g001
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Follow-up images of the wound at two weeks postoperative for stitch removal
PMC10979719_cureus-0016-00000055137-i05
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Myocardial bridging (MB) demonstrated by invasive coronary angiography during diastole (a) and systole (b). There was a significant narrowing on the anterior descending coronary artery during systole (white arrows). The MB on the diagonal branch (red arrows) or any other branch was rare and not analyzed in this study. The length from the beginning to the end of the coronary artery narrowing was measured as MB length (c)
PMC8375129_12872_2021_2204_Fig1_HTML
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Chromosome staining by click raction.(a) Schematic of the click reaction for staining chromosomal DNA at the individual chromosome level. EdU was introduced into chromosomal DNA as a labeling tag for a click reaction. Alexa488-azide (green) or Alexa594-azide (red) reacted with EdU to stain the individual chromosome. (b) Chromosomes were stained with Alexa488-azide (green) or Alexa594-azide (red). The inset panel is at higher magnification. Observed by fluorescence microscopy.
PMC5020420_srep33217-f1
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Surface location of nerve block.
PMC8709754_JHE2021-7245566p006
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Preoperative picture of the verrucous squamous cell carcinoma developing over a longstanding lesion of hypertrophic lichen planus.
PMC4006557_CRIDM2014-205638p002
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
H&E staining for the PCL electrospun meshes implanted after 7 days. (A) Reconstruction of the full membrane; (B,C) Interior membrane sections; (D,E) End-limits of the meshes.
PMC9415937_polymers-14-03397-g003
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Chest X-ray imageScattered calcified lesions in the left lower lung.
PMC9904801_cureus-0015-00000033493-i01
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Oncolytic virotherapy strategies for metastatic cancer treatmenta. Immunostimulatory factors (GM-CSF, IL-12) that are expressed in infected tumor cells recruit immune cells that induce tumor cell apoptosis. b. Anti-metastatic factors that are expressed in infected tumor cells block the metastasis pathway of the tumor cell and kill the tumor via their oncolytic capacity. c. Oncolytic virus infected stem cells replicate within the stem cells, which then migrate toward tumor lesions and release oncolytic viruses that infect tumor cells and induce oncolysis.
PMC5295462_oncotarget-07-58684-g002
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
CRLM has significant amounts of microbiota, which promotes disease progression.A Overview of the fraction of microbiota from the tumor samples by 16 s rDNA sequencing. Patients are grouped into separate plots based on sample location and with or without liver metastasis (CRC-C, CRLM-C, and CRLM-L). Each color represents a kind of microbiota, and the length of each color represents the abundance of the microbiota in each kind of tumor sample in general. B The numbers of microbiota from the tumors (n = 20) in CRC-C, CRLM-C, and CRLM-L were collected and detected by qPCR. Error bars indicate SEM. Statistics were determined using a t-test with significance indicated (ns, not significant. **p < 0.01). C Representative whole-body bioluminescence images (up) of mice orthotopically xenografted after intravenous injection with MC38-luc+ cells and representative images of liver metastasis (down) from control, antibiotics-treated group (Abx) and E.coli-treated group mice (n = 10). D Representative co-immunofluorescence images of CD206(M2 marker) and DAPI (nuclear counterstain) in tumors from mice in (C). Scale bars, 100 μm. Objective, 10x. E Representative immunofluorescence images of mCherry(E.coli marker) in para tumor (PT) and liver tumor (T) from mice gavaged with mCherry-E.coli at day 21. Scale bars, 100 μm. Objective, 5x. F Representative co-immunofluorescence images of staining for mCherry(E.coli marker), CD206(M2 marker), Foxp3(Treg marker), and DAPI(nuclear counterstain) in tumors from mice in liver metastasis from control, low dose and high dose E.coli-treated group mice (n = 10) at day 21. Scale bars, 100 μm Objective, 10x and 5x. G Representative co-immunofluorescence images of staining for CD206(M2 marker) and DAPI (nuclear counterstain) liver metastasis from control, antibiotics-treated, and E.coli(iv) injected group mice (n = 10) at day 21. Scale bars, 100 μm. Objective, 10x. H Representative co-immunofluorescence images of staining for iNOS(M1 marker) and DAPI(nuclear counterstain) liver metastasis from control, antibiotics-treated, and E.coli(iv) injected group mice (n = 10) at day 21. Scale bars, 100 μm. Objective, 10x.
PMC11281901_41388_2024_3080_Fig1_HTML
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Proposed model of STING-dependent regulation of microglial function in genome instability. Persistent DNA damage, such as that observed in ATM deficiency, leads to formation of micronuclei in proliferating microglia. Activation of the cGAS-STING pathway culminates in IRF3 activation and production of type I interferons and chemokines, including CCL5 and CXCL10. Secreted inflammatory mediators likely mediate a transition from homeostatic functions of microglia to chronic inflammation and chemotaxis to reactive microglia via autocrine and/or paracrine signalling, promoting chronic inflammation and chemotaxis. Blockade of STING rescues this process and has potential to alleviate perturbations to CNS homeostasis in genome instability.
PMC10853792_gkad1184fig7
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Ktrans and kGad (A) and test-retest kw (B) maps from subjects with (top row) and without (bottom row) WMH. (C) FLAIR, Ktrans, kGad, and kw maps (first visit) in normalized MNI space from the same subject as shown in the top row. Ktrans, kGad, and kw maps were overlaid on the FLAIR image. One WMH lesion was indicated by a red arrow and a dashed red circle and WMH penumbra was indicated by an orange circle on each image.
PMC7733970_fnins-14-571480-g0008
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Diagnostic nasal endoscopy showed a greyish mass filling the whole of the right nasal
PMC7007993_ijo-32-053-g001
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
A axial CT scan showing a pantaloon urinary bladder herniation (red arrow) with a calculus (blue arrow).
PMC9729010_cureus-0014-00000031208-i01
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
AFM imaging of DNA loop, GTF, nucleosome and HMGA1 positioning on the IL2RA gene promoter.(A) AFM imaging in liquid of DNA loop positioning along the 1290 bp IL2RA fragment (upper right panel) and the 898 bp IL2RA fragment (lower right panel) and statistical analysis (left panel) of their positioning given by the loop middle point (green vertical bars) from N = 21 AFM images. (B) AFM imaging of TBP-TFIIB positioning along the 563 bp IL2RA fragment (right panels) and statistical analysis (left panel) of their positioning (orange vertical bars) from N = 51 AFM images. (C) AFM imaging of mononucleosome positioning along the 898 bp IL2RA fragment (right panels) and statistical analysis (left panel) of dyad positioning (blue vertical bars) from N = 100 AFM images. (D) AFM imaging of HMGA1 positioning along the 898 bp IL2RA fragment (right panels) and statistical analysis (left panel) of dyad positioning (blue vertical bars) from N = 73 molecules.
PMC3076448_ponep0018811pg003
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
(a) Gastroscopy showed a round tumor at the anterior wall of the gastric body. (b) The resected tumor was 2 cm in diameter.
PMC2946604_CRM2010-348761p001
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
A gray-black mass compatible with bezoar was seen in the stomach via upper gastroendoscopy.
PMC11346831_medi-103-e39227-g002
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Example test case from the “seen” data data source (Dataset 1). The performance of the top algorithms #53 and #38 is shown in green and blue, respectively. Ground truth annotations are shown in red (a: axial view, b: coronal view).
PMC8183044_nihpp-rs571332v1-f0006
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Cryolesion (diameter = 0.80 cm) at 1 minute and 30 seconds into the freeze cycle. Note the hyperechoic rim with posterior acoustic shadowing emanating from the tip of the probe.
PMC3350006_CRIMpANESTHESIOLOGY2011-691478p004
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Effects of WS070117 on steatosis and de novo lipids synthesis in OLA-HepG2 cells. A: Oil Red O stain of 0.25 mM OLA-induced cellular lipid accumulation in WS070117 treated HepG2 cells. 12h treatment of WS070117 (10 μM) reduced the lipid droplets amount in HepG2 cells. B: TAG and TC synthesis was measured by the lipid accumulated from [1-14C] acetic acid, and was measured in control and WS070117 (0.1, 1, 10 μM) 12-h-treated OLA-HepG2 cells. **P < 0.01, *P < 0.05 as compared with OLA or HFD models.
PMC3112420_1476-511X-10-67-3
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Redundant anterior descending artery. In some series of coronarography the anterior descending artery has shown a longer than average length and a longer recurrent diaphragmatic segment.
PMC9979875_pocusj-07-15296-g003
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Anteroposterior (A) ,oblique (B) and lateral(C) X-rays showing radiopalmar dislocation of the fifth carpometacarpal joint
PMC3976671_PAMJ-16-90-g001
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Postoperative aspect of the implant on the anteroposterior and lateral view, respectively. Note: actual implant sizes were size 8 for the femoral component and size 56 for the acetabular component.
PMC10342509_jcm-12-04503-g003
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Co-misexpression of brain TFs triggers nerve cord overgrowth.(A) Control CNS (elav-Gal4/+) at AFT shows a few mitotic cells (PH3) in the brain lobes, but none in the nerve cord. (A´) Close-up of a mitotic NB and (A´´) a mitotic daughter cell. (B) Misexpression of four brain TFs, elav-Gal4 > UAS Tetra (UAS-erm, UAS-Doc2, UAS-tll, UAS-otp), triggers aberrant proliferation in the nerve cord at AFT. (B´) Close-up of a mitotic NB and (B´´) a mitotic daughter cell. (C) Quantitation of mitotic NBs and daughter cells per nerve cord (mean ± SEM; n ≥ 5 embryos per genotype) in control and different misexpression combinations of UAS transgenes. (D) Quantitation of total cell numbers in the nerve cord, in control (elav-Gal4/+), elav > UAS tll,-erm and elav > UAS Tetra (Student's t test; ***p<0.001; mean ± SEM; n ≥ 9 embryos). (E-G) Dpn + cells (NBs) in control (elav-Gal4/+), elav > UAS tll,-erm and elav > UAS Tetra. (H) Quantification of NB numbers (Dpn + cells) at St13 in T2 (Student's t test; ***p<0.001; mean ± SEM; n ≥ 10 embryos per genotype). (I-J) Nerve cords showing NBs (Dpn+) and the NB5-6 lineage (lbe(K)-GFP) at St15, in control (I; wg-Gal4/+; lbe(K)-GFP/+) and wg-Gal4 > UAS Tetra, showing an increased number of NBs (Dpn+), mitotic cells (PH3+) and an expanded NB5-6 lineage. (K) Quantitation of NB5-6 lineage cell numbers in the T2-T3 segments, at St15 (Student's t test; ***p<0.001; mean ± SEM; n ≥ 10 embryos, n ≥ 32 lineages). All confocal images are maximum intensity projections of multiple focal planes. Zoomed in images are single optical sections.10.7554/eLife.45274.010Figure 2—source data 1.Estimated average cell volume per region and genotype at AFT.
PMC6634974_elife-45274-fig2
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Effect of Ig-saporin on neuronal survival in different hippocampal areas. Brain sections of rats intracerebroventricularly treated with PBS (A,C,E) or Ig-saporin (B,D,F) were Nissl-stained and the number of neurons was counted as described in the methods. Ig-saporin had no effect on the number of neurons in CA1 (A,B) and CA4 (E,F,G) areas but induced a significant decrease in the number of CA3 neurons in the pyramidal layer. This decrease was associated with an increase in the number of CA3 pyramidal neurons in the extrapyramidal space (CA3e, panel E). ∗Significant difference compared to control (p = 0.013); ∗∗significant difference compared to control (p = 0.006).
PMC6424051_fnins-13-00146-g005
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
(A) Example of a tumor (T) with high MMP-27 expression at the bone-tumor interface (200× magnification). The tumor shows a bulky appearance and was rather distant to the adjacent bone (marked with B). (B) Tumor with low expression of MMP-27; the tumor mass is comprised of islets and in close proximity to the bone. (C) Surprisingly, the staining signal of MMP-27 was not only limited to the cytoplasm, but also detectable on the cell membrane (600× magnification). MMP-27 is usually confined to the endoplasmic reticulum. (D,E) Demonstration of the effect of MMP-27 on tumor morphology (sections without bone tissue). (D) This tumor shows high expression of MMP-27; the cells grow adjacent to each other. (E) On the other hand, this sample with low expression of MMP-27 shows single cells and clusters detached from the main tumor, which is often referred to as tumor budding.
PMC9406335_cancers-14-04044-g004
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Fundal photos of the right and left eyes on presentation demonstrating intraretinal haemorrhages, cotton wool spots and Purtscher flecken with the characteristic clear zone between the lesions and the blood vessels.
PMC9792245_CRIOPM2022-7870179p001
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Adjustment of the memory alloy embracing device according to the 3D model. (A) Front view showing well-placed hoops. (B) Some fixations do not fit well to the ribs (red arrows); an embracing arm fails to wrap around the rib rim, partially off (white arrow). (C) Back view showing the embracing device does not match the rib size: the embracing device is wide and the rib is narrow (yellow arrows). (D) From the foot side, an embracing arm fails to wrap around rib rim, partially off (blue arrow). (E-G) The head side, foot side and front side of the embracing device are well fixed
PMC10426142_12893_2023_2128_Fig3_HTML
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Fluoroscopic View of Balloon Filled by Contrast Media
PMC3821110_aapm-02-42-g005
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Illustration of longitudinal image and label alignment for AMD and Stargardt data. Note the hypo-fluorescence regions on the FAF images are AMD atrophic lesions (i.e., GA) (upper row) and Stargardt atrophic lesions (bottom row) respectively.
PMC9418226_41598_2022_18785_Fig2_HTML
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Weightbearing radiographs showing changes in bony width preoperative (BW1) and postoperative (BW2) after triplanar first tarsometatarsal arthrodesis. Bony width was defined as the distance from the most medial aspect of the first metatarsal head to the most lateral aspect of the fifth metatarsal head.
PMC8697068_10p1177_2473011420934804-fig1
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Two years follow up fluoroscopy.
PMC4164749_13019_2014_Article_138_Fig7_HTML
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
a Low-power view demonstrating a partially encapsulated nodular mass without dermal connection. b, c Cellular and mildly atypical spindle cells with brisk mitoses (arrows), arranging in elongated fascicles and herringbone patterns. d Focal collagenized stroma. e Minor areas displaying classic dermatofibrosarcoma protuberans with storiform growth and entrapment of adipocytes. f Immunoreactivity for CD34
PMC8276425_13000_2021_1123_Fig1_HTML
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Illustration of segmentation failure examples.(a) BUS Images, (b) ground truth, (c) CTG-Net predictions. Image (1) is from the THH dataset, images (2) and (3) are from the UDIAT dataset, and image (4) is from the BUSI dataset. The text represents the category labels.
PMC9371312_ponep0271106pg011
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Confocal micrographs of apoptotic ICC-IM (A–E), ICC-MY (F–J) and ICC-SM (K–O).Only a few number of c-kit+/TUNEL+ cells were found in the control group (A, F, K), while the damaged networks of ICC in the DM group were flood by TUNEL+ nucleus (B, G, L). It was also revealed that plenty of apoptotic ICC-IM (C), ICC-MY (H) and ICC-SM (M) in the SEA group. The cellular networks of all layers in the LEA (D, I, N) and HEA group (E, J, O) presented with few apoptotic ICC. Quantitative analysis of ICC-IM, ICC-MY and ICC-SM were carried out in different groups in P-R. *P<0.05 compared with the control, # P<0.05 compared with the DM group. Scale bars  = 20 µm.
PMC3877115_ponep0083904pg004
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Generation of AtmTgERT2-LBD transgenic mouse model.a Schematic representation of BAC construct for the generation of mouse models carrying a tamoxifen-inducible version of wild-type Atm. The pCRE-ERT2 plasmid was used to amplify the modified mouse estrogen receptor ligand-binding domain (ERT2-LBD). Primers for ERT2-LBD amplification were flanked by 100 bp Atm oligos surrounding the ATG site. Three glycine residues were introduced between the 3′ end of LBD and the first amino acid of Atm to ensure the correct protein folding. The Atm-ERT2-LBD-Atm fragment was inserted into the wild-type Atm BAC RP24-122F10 by homologous recombination to obtain an AtmTg ERT2-LBD BAC. The first intron is reported in the scheme. b Sequence chromatogram showing the correct insertion of Atm-ERT2-LBD-Atm fragment in the murine Atm BAC. c Western blot analysis showing AtmTg ERT2-LBD expression in thymocytes of two founder lines (G3 and C8) crossed to Atm+/− mice. Endogenous Atm (lower band) and transgenic Atm (upper band) are shown. d Immunofluorescence on AtmTg ERT2-LBD Atm−/− embryonic mouse fibroblasts treated or not for 24 h with 4-OHT and damaged with NCS 500 ng/ml for 10 min. ERβ staining (green) to detect Atm and γ-H2AX (red) are shown. DAPI was used to stain nuclei. Scale bar 50 μm
PMC5833483_41419_2018_357_Fig1_HTML
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Compared with healthy non-smokers (P < 0.05, Family-wise error (FWE) corrected), young smokers showed significantly decreased gray matter (GM) volume in the left anterior cingulate cortex (ACC; A) and increased GM volume in the left putamen (B). The GM volume of the left ACC has a negative correlation trend with pack-years, but not a significant correlation. The GM volume of the left putamen was positively correlated with pack-years (C). Pack-years = smoking years × daily consumption/20.
PMC5047919_fnhum-10-00494-g0001
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
In vivo bio-distribution of anti-ICAM/SV/NLCs. (A) The fluorescence images of excised representative organs from mice. The column in each image sequentially showed the anti-ICAM/SV/NLCs bio-distribution in the representative organs of the healthy mice, saline-challenged mice and LPS-induced mice, from left to right. The non-targeted SV/NLCs-3 bio-distribution in the LPS-induced mice was reflected in the leftmost column. (B) The semi-quantified fluorescence intensity in the representative organs, expressed as the average fluorescence intensity (avg signal/counts).
PMC8248938_IDRD_A_1259369_F0004_C
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Gallstone seen near top of common bile duct.
PMC5530427_CRIS2017-5878614p001
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
M-mode ultrasonography of tongue movement during breastfeeding. Slope measurement: yellow line 1, 2, 3 and 4; sucking cycle duration: yellow line 5, 6, 7 and 8.
PMC10670838_diagnostics-13-03435-g005
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Effect of RSV on intestinal morphology of weaned mice. (A) Ileum morphology of mice in each group was evaluated by hematoxylin and eosin (HE) staining. (B) Villus length, crypt depth, and the ratio of villus length to crypt depth of RSV-treated mice. Con = control group, RSV10 = 10 mg/kg RSV, RSV20 = 20 mg/kg RSV, RSV50 = 50 mg/kg RSV. All the data are expressed as the means ± SEM.
PMC8446547_fmicb-12-726878-g002
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
HOB® osteoblasts grown on SCS8 sample after 24 h in culture (A) and examined with a phase-contrast microscope, showing cell elongation, organization, and polarization towards aerogel particles. In (B), cells are imaged in the fluorescence mode by the confocal microscope, showing osteoblasts polarization and approach to the material. Grayscale allows for the identification of actin immunolabeling (white) and shows how cells start to colonize the material surface (black). (right bottom bar 100 μm).
PMC7760707_polymers-12-02802-g010
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
(A) Sagittal STIR, (B) T1-weighted sequence. Images show Romanus lesions as tiny subchondral bone marrow oedema (hyperintensities) in the antero-superior corners of lumbar vertebral bodies on STIR and, after the active phase, residual fatty transformation in the same regions on T1.
PMC10093281_diagnostics-13-01342-g003
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
ACSL3:ETV1 fusion. (A) ACSL3 (red) and ETV1 (blue) transcripts with ORFs in dark colour. Exons are numbered. A fusion transcript of ACSL3 exon 3 fused to ETV1 exon 6 was detected by 5′-RACE from exon 6 ETV1 sequences in prostate cancer sample 23. The ORF shown was predicted using software at www.dnalc.org. (B) Sequence across the ACSL3:ETV1 fusion boundary. Underlined regions indicate the position of primers used in RT–PCR to confirm the fusion. The predicted fusion gene initiation codon is indicated in red. ACSL3 sequence is in lower case and ETV1 sequence in upper case. (C) RT–PCR detection of an ACSL3:ETV1 fusion transcript in RNA extracted from formalin-fixed paraffin-embedded prostate cancer samples: lanes 1–12 are ETV1-rearranged tumour samples, lane 12: tumour sample 23, lane 13 negative control. (D) FISH assays to confirm fusion of ACSL3 with ETV1. Panel i: The ETV1 break-apart assay utilises probes corresponding to 3′-ETV1 sequences (red) and 5′-ETV1 sequences (green) (see also Figure 1). A nucleus with separated red and green probes confirming rearrangement of ETV1 is shown. Panel ii: The ACSL3 break-apart assay hybridised the same TMA slice used in the ETV1 break-apart assay to 3′-ACSL3 sequences (red) and 5′-ACSL3 sequences (green). These signals are coincident in the wild type, but are split on translocation of ACSL3. Comparison of the images in panels i and ii indicates co-localisation of 3′-ETV1 with 5′-ACSL3 and co-localisation of 5′-ETV1 and 3′-ACSL3. This is confirmed by ETV1-ACSL3 co-localisation assays (panel iii) demonstrating co-localisation of 3′-ETV1 sequences (red) and 5′-ACSL3 sequences (green) and (panel iv) demonstrating co-localisation of 3′-ACSL3 sequences and 5′-ETV1 sequences (red) in the same cell. Superimposition of the images in panels iii and iv confirms co-localisation of wild-type 3′-ETV1 (panel iii) with 5′-ETV1 (panel iv) and of wild-type 3′-ACSL3 (panel iv) with 5′-ACSL3 (panel iii). The genes and their direction of transcription are indicated by the arrowheads. (E) Map of the ACSL3 gene showing the position of the BACs used as probes in FISH assays. Probe XV: A1 (RP11-157M20) labelled with FITC. Probe XIV: A2 (RP11-136M23) and A3 (RP11-749C15) labelled with Cy3. Probes XV and probes XIV correspond, respectively, to sequences immediately 5′ (green) and 3′ (red) to the ACSL3 gene. Direction of gene transcription indicated by arrowheads.
PMC2480965_6604472f3
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
CT images of patient 2 treated with pazopanib. a CT scan at start of pazopanib showing a large sacral chordoma reaching from S2 to coccygis. Measurements: 20 × 16 × 13 cm (AP × LR × CC). b CT scan after 15 months of pazopanib showing progressive disease. Measurements: 21 × 24 × 23 cm (AP × LR × CC)
PMC5088663_13569_2016_59_Fig1_HTML
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Immunochemical characterization of the endosomal alterations observed in SH-SY5Y APPswe cells. (a) Immunochemical staining of EEA1 (red) and nuclei (blue) in WT and APPswe SH-SY5Y cells. (b) Number and area of early endosomes, referring to EEA1-positive spots normalized to the cell number. Signals were detected using confocal microscopy, at 60X and 120X magnification, and quantified using ImageJ 1.52 software. Results are presented as means (±SEM, N = 4 independent experiments, n = 5 separate random fields per experiment). (c) NTA quantification of exosomes secreted in the culture media. (d) Western blot demonstration of the presence of APP specifically in the APPswe cells and their related exosomes, using flotillin-1 as a reference (analyzed from a distinct blot). Selected lanes have been cut out from the original blot images to allow for a representative profile to be shown. Results are presented as means (±SEM, N = 3 independent samples and n = 5 measurements per sample). Statistical analyses were performed via Student or Mann–Whitney tests, and significant differences are indicated as * p < 0.05 and *** p < 0.001.
PMC11240902_ijms-25-06816-g001
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Characteristics of fundus in LHON patients. a The early manifestation of fundus (within 1 week): retinal vein and artery expanded around the optic disk. Edema and hyperemia surrounding the optic disc were observed. b The late stages (over 6 months): retinal vein and artery have become tapered and stiff. The optic disc is pale and atrophic
PMC4919274_40064_2016_2540_Fig3_HTML
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Representative cases. Panel A demonstrates the brain MRI of a 68‐year‐old man with CHIP with DNMT3A mutation (variant allele fraction VAF value of 5.8%) and well‐controlled hyperlipidemia (total cholesterol level of 182 mg/dL and LDL cholesterol level of 87 mg/dL) but without other cerebrovascular risk factors. The normalized value of total white matter hyperintensity (WMH) volume was 0.2%. Panel B demonstrates the brain MRI of a 66‐year‐old man with well‐controlled diabetes (hemoglobin A1c of 5.4%) but without CHIP or other cerebrovascular risk factors. The normalized value of total white matter hyperintensity (WMH) volume was 5.9%.
PMC10068463_CNS-29-1243-g003
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
The range of motion of the shoulder is good, and the flap is not bulky and maintains good conformity.
PMC10174365_medi-102-e33672-g004
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Ultrastructural characteristics of SII and SIH20B by SEM at various magnifications. SEM images (A,B) were taken at Mag = 90×, and SEM images (C,D) were taken at Mag = 345×.
PMC11241537_foods-13-02045-g003
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
(a) In situ condensation (arrows) at 100% humidity, (b) magnified image of the same coating at similar condensation conditions, (c) ice formation, and (d) ice anchoring mechanism (circles) on the superhydrophobic PDMS-based coating. Reproduced with permission from [80].
PMC10342894_materials-16-04607-g006
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Acid-Schiff staining.Milder renal pathology is observed in 5/6Nx EP4+/− mice. Kidneys are removed and disease pathology is visualized by periodic acid–Schiff staining of paraffin-embedded sections at 8 weeks after 5/6 Nx. Milder glomerular pathology is observed in 5/6 Nx EP4+/− mice with less matrix deposition than 5/6 Nx WT mice. Magnification,400.
PMC4133176_ponep0104091pg010
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
The effect of tunnel current on the 75/25 sample.(a) The initial scan (19 pA, 2.6 V) and (b) final scan (19 pA, 2.6 V) show extensive surface modification with the formation of numerous large clusters and the movement of material away from the central scan area, exposing the subsurface small clusters. Images (c–f) show snapshots from the tunnel current ladder with currents 100 pA, 210 pA, 370 pA and 520 pA respectively (all at 2.6 V). Each sequence consisted of 5 images acquired over 3.5 minutes. (g) Shows the frequency of spontaneous surface cluster mergers as a function of tunnel current as calculated over available data from the Cu75Hf25 sample. (h) Shows the counted density of highly active (flickering) clusters present on the surface during tunnel current variation experiments.
PMC4976322_srep30973-f2
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Chest X-ray of the patient(A) chest X-ray showed no evidence of active chest disease; (B) chest x-ray demonstrating cardiomegaly, left basilar infiltrate versus atelectasis
PMC7990470_cureus-0013-00000013496-i03
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
SEM images of carbon nanofibers (a) before activation and (b) after activation for 30 min by ammonia.
PMC9267233_materials-15-04387-g002
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
a The pathological changes of liver and kidney tissues in each group b The organ index of ovaries and uterus increased significantly in the treatment groups. *P < 0.05 **P < 0.01, compared with the MOD group
PMC7405416_13020_2020_362_Fig3_HTML
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Follow-up MRI evaluation (26/03/2020) with T1 Fat Sat MRI images with intravenous gadolinium contrast (a) dan DWI (b) as well as ADC mapping (c) . On T1fat sat post-contrast showed reduction of the overall mass size and the composition of the viable area (white arrows) (a) Recent DWI with ADC mapping MRI demonstrated a value of 1.22–1.41 × 10–3 mm2/s in the solid area and a value of 2.02–2.17 × 10–3 mm2/s in the necrotic area (white arrows) (b, c). ADC, apparent diffusion coefficient; DWI, diffusion-weighted imaging.
PMC8749407_bjrcrp20210015pg010
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
(A) T2WI, (B) T1WI, and (C) FLAIR: axial section of the brain showing multiple altered signal intensity areas mostly cystic, noted diffusely in the subcortical and deep periventricular white matter and corpus callosum appearing hyperintense on T2 and hypointense on T1 and FLAIRT2WI: T2-weighted imaging; T1WI: T1-weighted imaging; FLAIR: fluid-attenuated inversion recovery
PMC11184629_cureus-0016-00000060593-i02
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
(a–c) Exemplary CT and echocardiographic findings of a left atrial myxoma attached to the interatrial septum.
PMC10003994_jcm-12-02075-g001
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Dex treatment reduced myocardial apoptosis. (A,B) Representative TUNEL staining images and quantitative data in each group. (C,D) Representative images of Western Blot analysis in each group. (E–I) Relative expression levels of Bcl-2, Bax, Caspase3, and Cleaved Caspase3 in each group. Data are expressed as mean ± SD. **p < 0.01, ***p < 0.001 vs. the ECMO group.
PMC9343845_fpubh-10-900751-g0004
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
Representative histopathology figures before and after BM-MSCs treatment. At day 0, typical IFTA histopathology characteristics such as interstitial fibrosis, inflammatory cells infiltration, tubular epithelial atrophy and glomerulosclerosis were noticed; these characteristics were somewhat alleviated at 6 months after the intra-arterial infusion of BM-MSCs. BM-MSCs: bone marrow-derived mesenchymal stem cells.
PMC8425735_IRNF_A_1968432_F0004_C
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
The steps involved in the interstitial PDT application to treat a left infraorbital haemangioma. (A): The patient is prepared with a drape and eye shield. (B): US is used to accurately identify the location of the lesion. (C): The locations for needle insertion are mapped out superficially. (D): US is used during the insertion of the first needle. (E): US is used for the insertion of subsequent needles. (F): The needles are inserted an appropriate distance from each other to ensure complete illumination of the tumour width and depth. (G): The needle tip in the tissue is measured to avoid damage in order to avoid necrosis of overlying healthy tissue. (H): The lesion is illuminated. Reprinted with permission from ref. [34]. Copyright 2011 Photodiagnosis Photodyn. Ther.
PMC8509369_jcm-10-04404-g003
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar
LL-37 triggers import of poly I:C in BEAS-2B cells. (A–D) Cells were treated with fluorescent rhodamine-tagged poly I:C (4 µg/mL) alone or in combination with LL-37 (4 µM) for 6 (A,B) and 24 h (C,D). The intracellular fluorescence signal (red) and the nuclei staining with DAPI (blue) were analyzed and photographed using a fluorescence microscope equipped with a digital camera. The bars in panel A and C represent 40 µm. The fluorescence intensity of five cells was measured in three different areas on each coverslip, and an average cellular fluorescence intensity was calculated for each experiment. Data are presented as mean ± SEM, n = 4 in each group representing the number of independent experiments. Statistical significance was calculated using a one-way ANOVA, followed by Tukey’s post hoc test. ** represents p < 0.01 vs. control. For comparisons indicated by the bars, ** represents p < 0.01.
PMC8962275_biomedicines-10-00492-g005
hf://datasets/skip113/bmc_original_1M@cb1dbfbcc0c49bc52a659d744321d5b08523848d/data/000001.tar