title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Topic maps for exploring nosological, lexical, semantic and HL7 structures for clinical data. | A topic map is implemented for learning about clinical data associated with a hospital stay for patients diagnosed with chronic kidney disease, diabetes and hypertension. The question posed is: how might a topic map help bridge perspectival differences among communities of practice and help make commensurable the diffe... | 19,008,277 |
Pinhole versus parallel-hole collimators for parathyroid imaging: an intraindividual comparison. | This study was undertaken to determine the effects of collimators on the accuracy of preoperative sestamibi parathyroid imaging of the neck. Forty-nine patients with primary hyperparathyroidism underwent preoperative (99m)Tc-sestamibi parathyroid imaging. The protocol included early and late pinhole and parallel-hole i... | 19,008,287 |
Poor vision accompanied with other sensory impairments as a predictor of falls in older women. | we studied visual acuity (VA) and co-existing hearing impairment and poor standing balance as predictors of falls. prospective study with 1-year follow-up. research laboratory and residential environment. 428 women aged 63-76 years from the Finnish Twin Study on Aging. participants were followed up for incidence of fal... | 19,008,307 |
Corticotropin-releasing hormone receptor expression and functional signaling in murine gonadotrope-like cells. | Corticotropin-releasing hormone (CRH) is a key regulator of the mammalian stress response, mediating a wide variety of stress-associated behaviors including stress-induced inhibition of reproductive function. To investigate the potential direct action of CRH on pituitary gonadotrope function, we examined CRH receptor e... | 19,008,330 |
The effect of human GATA4 gene mutations on the activity of target gonadal promoters. | GATA transcription factors are crucial regulators of cell-specific gene expression in many tissues including the gonads. Although clinical cases of reproductive dysfunction have yet to be formally linked to GATA gene mutations, they have begun to be reported in other systems. Heterozygous GATA4 mutations have been asso... | 19,008,335 |
Overexpression of SIRT1 protects pancreatic beta-cells against cytokine toxicity by suppressing the nuclear factor-kappaB signaling pathway. | SIRT1, a class III histone/protein deacetylase, is known to interfere with the nuclear factor-kappaB (NF-kappaB) signaling pathway and thereby has an anti-inflammatory function. Because of the central role of NF-kappaB in cytokine-mediated pancreatic beta-cell damage, we postulated that SIRT1 might work in pancreatic b... | 19,008,341 |
Pacemakers handshake synchronization mechanism of mammalian respiratory rhythmogenesis. | Inspiratory and expiratory rhythms in mammals are thought to be generated by pacemaker-like neurons in 2 discrete brainstem regions: pre-Bötzinger complex (preBötC) and parafacial respiratory group (pFRG). How these putative pacemakers or pacemaker networks may interact to set the overall respiratory rhythm in synchron... | 19,008,356 |
Do walking and leisure-time physical activity protect against arthritis in older women? | To examine the prospective dose-response relationships between both leisure-time physical activity (LTPA) and walking with self-reported arthritis in older women. Data came from women aged 73-78 years who completed mailed surveys in 1999, 2002 and 2005 for the Australian Longitudinal Study on Women's Health. Women repo... | 19,008,369 |
Global health equity: evidence for action on the social determinants of health. | More than 30 years ago, the older of us published a paper with the proposal that all scientific papers should start with a statement along the lines of: "These are the opinions on which I base my facts". Why pretend? To take a topical example, if you are on the nature side of the nature/nurture debates, is it likely th... | 19,008,370 |
Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus. | Foxp3(+) CD4(+) regulatory T (T(reg)) cells play a pivotal role in the maintenance of dominant self tolerance. Understanding how the failures of immune control by T(reg) cells are involved in autoimmune diseases is important for the development of effective immunotherapies. In the present study, we analyzed the charact... | 19,008,373 |
Detection of bovine papillomavirus type 2 in the peripheral blood of cattle with urinary bladder tumours: possible biological role. | Bovine papillomavirus type 2 (BPV-2) infection has been associated with urinary bladder tumours in adult cattle grazing on bracken fern-infested land. In this study, we investigated the simultaneous presence of BPV-2 in whole blood and urinary bladder tumours of adult cattle in an attempt to better understand the biolo... | 19,008,389 |
Accumulation of calcium in the centre of leaves of coriander (Coriandrum sativum L.) is due to an uncoupling of water and ion transport. | The aim of this study is to understand the parameters regulating calcium ion distribution in leaves. Accumulation of ions in leaf tissue is in part dependent on import from the xylem. This import via the transpiration stream is more important for ions such as calcium that are xylem but not phloem mobile and cannot ther... | 19,008,410 |
Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. | Enhancer of zeste homolog 2 (EZH2) is a mammalian histone methyltransferase that contributes to the epigenetic silencing of target genes and regulates the survival and metastasis of cancer cells. EZH2 is overexpressed in aggressive solid tumors by mechanisms that remain unclear. Here we show that the expression and fun... | 19,008,416 |
A role for the ESCRT system in cell division in archaea. | Archaea are prokaryotic organisms that lack endomembrane structures. However, a number of hyperthermophilic members of the Kingdom Crenarchaea, including members of the Sulfolobus genus, encode homologs of the eukaryotic endosomal sorting system components Vps4 and ESCRT-III (endosomal sorting complex required for tran... | 19,008,417 |
IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner. | The CD31(+) subset of human naive CD4(+) T cells is thought to contain the population of cells that have recently emigrated from the thymus, while their CD31(-) counterparts have been proposed to originate from CD31(+) cells after homeostatic cell division. Naive T-cell maintenance is known to involve homeostatic cytok... | 19,008,454 |
Novel markers reveal subpopulations of subplate neurons in the murine cerebral cortex. | The subplate lays the foundation of the developing cerebral cortex, and abnormalities have been suggested to contribute to various brain developmental disorders. The causal relationship between cellular pathologies and cognitive disorders remains unclear, and therefore, a better understanding of the role of subplate ce... | 19,008,461 |
Variation in outcome after subarachnoid hemorrhage: a study of neurosurgical units in UK and Ireland. | The purpose of the study was to describe the characteristics, management, and outcomes of patients with confirmed aneurysmal subarachnoid hemorrhage and to compare outcomes across neurosurgical units (NSUs) in the UK and Ireland. A cohort of patients admitted to NSUs with subarachnoid hemorrhage between September 14, 2... | 19,008,474 |
Mesenteric lymph duct ligation prevents trauma/hemorrhage shock-induced cardiac contractile dysfunction. | Clinical and experimental studies have shown that trauma combined with hemorrhage shock (T/HS) is associated with myocardial contractile dysfunction. However, the initial events triggering the cardiac dysfunction are not fully elucidated. Thus we tested the hypothesis that factors carried in intestinal (mesenteric) lym... | 19,008,486 |
Cancer screening in US workers. | Regular cancer screening can prevent the development of some cancers and increase patient survival for other cancers. We evaluated the reported cancer screening prevalence among a nationally representative sample of all US workers with data from the 2000 and 2005 Cancer Screening Supplements of the National Health Inte... | 19,008,502 |
Overexpression of apolipoprotein F reduces HDL cholesterol levels in vivo. | Apolipoprotein F (ApoF) is a protein component of several lipoprotein classes including HDL. It is also known as lipid transfer inhibitor protein (LTIP) based on its ability to inhibit lipid transfer between lipoproteins ex vivo. We sought to investigate the role of ApoF in HDL metabolism. Adeno-associated viruses (AAV... | 19,008,531 |
Flow-based image abstraction. | We present a non-photorealistic rendering technique that automatically delivers a stylized abstraction of a photograph. Our approach is based on shape/color filtering guided by a vector field that describes the flow of salient features in the image. This flow-based filtering significantly improves the abstraction perfo... | 19,008,556 |
Multiscale time activity data exploration via temporal clustering visualization spreadsheet. | Time-varying data is usually explored by animation or arrays of static images. Neither is particularly effective for classifying data by different temporal activities. Important temporal trends can be missed due to the lack of ability to find them with current visualization methods. In this paper, we propose a method t... | 19,008,560 |
Calibration, registration, and synchronization for high precision augmented reality haptics. | In our current research we examine the application of visuo-haptic augmented reality setups in medical training. To this end, highly accurate calibration, system stability, and low latency are indispensable prerequisites. These are necessary to maintain user immersion and avoid breaks in presence which potentially dimi... | 19,008,561 |
Correlation of intra-operative frozen section consultation with the final diagnosis at a referral center in Karachi, Pakistan. | The correlation of intra-operative frozen section diagnosis with final diagnosis on permanent sections is an integral part of quality assurance in surgical pathology laboratories. However, there is scant data on this topic from Pakistan. Similarly, no local study has looked at frozen section turnaround times. To analyz... | 19,008,568 |
A clinicopathological study of malignant melanoma with special reference to atypical presentation. | Malignant melanoma is a tumor of melanocytic origin. Lymphatic and hematogenous metastases are common in this condition. Retrospective analysis was performed in 16 consecutive cases diagnosed histopathologically as malignant melanoma at the pathology department of a medial college in eastern India. 75% of the patients ... | 19,008,571 |
Mucin-producing signet ring cell adenoma of the thyroid. | Signet ring cell adenoma of the thyroid, though rare, is well documented. This change is chiefly due to intracellular accumulation of thyroglobulin that appears mucinous. Awareness of this entity is important as it may closely simulate a metastatic mucin-secreting signet ring cell carcinoma. Although the mucinous mater... | 19,008,577 |
Mucinous adenocarcinoma of the renal pelvis with pseudomyxoma peritonei. | Mucinous adenocarcinoma of the renal pelvis is an extremely rare tumor with very few case reports in literature. Pseudomyxoma peritonei is an uncommon condition characterized by the presence of mucinous gelatinous material in the peritoneal cavity. It occurs secondary to primary mucinous neoplasms of particularly the a... | 19,008,588 |
Chondroid lipoma in a child. | Chondroid lipoma (CL), a rare lipoma variant, has not been described well for patients younger than 14 years of age. We herein report an extremely unusual instance of CL in a 7-year-old child. The cut surface of the tumor showed peculiar tan-brown and yellow-white areas. Histopathological sections showed the presence o... | 19,008,590 |
Multiple myeloma presenting with coexisting severe marrow hypoplasia. | A 68-year-old man was referred to us with clinical and bone marrow (BM) features compatible with aplastic anemia. The correct diagnosis, hypoplasia of the BM coexisting with multiple myeloma, became apparent after noting rouleaux in the peripheral blood (PB) and approximately 50% plasma cells in the touch imprint of on... | 19,008,591 |
Erosive effects of acidic center-filled chewing gum on primary and permanent enamel. | The higher incidence of dental erosion in children and teenagers possibly reflects a high intake of acidic food and beverages as well as a more frequent diagnosis on this condition. The aim of this study was to evaluate the erosive potential of acidic filling of chewing gum in primary and permanent enamel. Eighty ename... | 19,008,622 |
Evaluation of different sterilization and disinfection methods on commercially made preformed crowns. | The aim of this study was to evaluate the changes caused by different sterilization or disinfection methods on the vestibular surface of four commercially made preformed crowns using stereomicroscopy and scanning electron microscopy (SEM). Preformed crowns (NuSmile Primary Anterior Crown (NSC), Kinder Krowns (KK), Pedo... | 19,008,625 |
Detection of diastolic abnormality by dyssynchrony imaging: correlation with coronary artery disease in patients presenting with visibly normal wall motion. | Post-systolic shortening (PSS) is a sensitive indicator of myocardial ischemia. We have developed a tissue Doppler imaging technique that portrays PSS, and whether PSS correlates with coronary artery disease (CAD) was investigated in 186 patients presenting with chest pain and normal echocardiograms. Delays of the disp... | 19,008,630 |
[The establishment of SUMC (Severance Union Medical College) Psychiatry Department and the formation of humanistic tradition]. | Psychiatry is a branch of medicine which deals with the problem of mental health. Although psychiatric concept and treatment is not absent in traditional medicine in Korea, it was not regarded as an independent discipline of medicine. Modern psychiatry was introduced into Korea as modern Western medicine w as introduce... | 19,008,654 |
Success indicators for integrating mental health interventions with community-based rehabilitation projects. | Community interventions for people with physical disabilities and for people with mental illness have evolved following similar trajectories, although at different periods of time. This study develops and tests indicators for successful integration of community-based rehabilitation (CBR)-mental health and development (... | 19,008,676 |
Outpatient cardiac rehabilitation attendance in England: variability by region and clinical characteristics. | Cardiac rehabilitation is an effective but underprovided treatment for patients recovering from acute cardiac events. The geographical spread of provision has not been investigated recently in any country. This study aimed to investigate the level of participation in cardiac rehabilitation programs of patients followin... | 19,008,693 |
Patterns of psychosocial adjustment following cardiac surgery. | The purpose of this research was to document the postoperative experiences of a group of cardiac surgery patients with a view to identifying factors relevant to postsurgical mood and adjustment. Forty-six cardiac surgery patients (mean age = 63.6 years, SD = 11.0) were recruited through a cardiac rehabilitation program... | 19,008,695 |
Measurement of functional activity in chronic obstructive pulmonary disease: the grocery shelving task. | The aim of this study was to develop a standardized test to evaluate functional performance, including arm activity, of patients with chronic obstructive pulmonary disease. Fifty-seven patients (mean forced expiratory volume in 1 second % predicted = 46) were recruited to measure reproducibility (n = 10) of a grocery s... | 19,008,696 |
Interactions between metallopeptidase 3 polymorphism rs679620 and BMI in predicting blood pressure in African-American women with hypertension. | BMI represents an internal metabolic and physiological environment that plays a key role in development of high blood pressure (BP) for many Americans. African-American women have a higher prevalence of high BP and being overweight than men or other ethnic groups. This study examines the genetic-environmental interacti... | 19,008,710 |
The beta-lactam antibiotic, ceftriaxone, dramatically improves survival, increases glutamate uptake and induces neurotrophins in stroke. | Ceftriaxone has been reported to reduce neuronal damage in amyotrophic lateral sclerosis and in an in-vitro model of neuronal ischaemia through increased expression and activity of the glutamate transporter, GLT1. We tested the effects of ceftriaxone on mortality, neurological outcome, and infarct size in experimental ... | 19,008,722 |
Integrated analysis of cardiac tissue structure and function for improved identification of reversible myocardial dysfunction. | Myocardial deformation imaging and contrast-enhanced cardiac magnetic resonance imaging (ceMRI) have been used to define myocardial viability in ischemic left ventricular dysfunction. This study evaluated the incremental predictive value of an integrated analysis of function and tissue structure for functional improvem... | 19,008,764 |
Relationship between bone mineral density and clinical features in women with idiopathic benign paroxysmal positional vertigo. | To evaluate the relationship between bone mineral density (BMD) and clinical features in women with idiopathic benign paroxysmal positional vertigo (IBPPV). Prospective study. Tertiary referral center. Patients with BMD measurements made after a diagnosis of IBPPV were included. The IBPPV (n = 78) and control groups (n... | 19,008,769 |
Assessing stapes piston position using computed tomography: a cadaveric study. | Temporal bone computed tomographic (CT) scanning in the postoperative stapedotomy patient is inaccurate in assessing stapes piston position within the vestibule. Poststapedotomy patients that have persistent vertigo may undergo CT scanning to assess the position of the stapes piston within the vestibule to rule out ove... | 19,008,770 |
Toll-like receptors in ischemia-reperfusion injury. | Ischemia-reperfusion (I/R) injuries are implicated in a large array of pathological conditions such as myocardial infarction, cerebral stroke, and hepatic, renal, and intestinal ischemia, as well as following cardiovascular and transplant surgeries. The hallmark of these pathologies is excessive inflammation. Toll-like... | 19,008,778 |
Retinoid X receptor alpha participation in dexamethasone-induced rat bile acid coenzyme A-amino acid N-acyltransferase expression in septic liver. | To test the hypothesis that dexamethasone (Dex) treatment would restore rat hepatic bile acid coenzyme A-amino acid N-acyltransferase (rBAT) expression in septic rats after cecal ligation and puncture by increasing expression of retinoic acid X receptor alpha (RXRalpha), we assessed survival rate and bile and bile salt... | 19,008,781 |
Mathematical modeling of posthemorrhage inflammation in mice: studies using a novel, computer-controlled, closed-loop hemorrhage apparatus. | Hemorrhagic shock (HS) elicits a global acute inflammatory response, organ dysfunction, and death. We have used mathematical modeling of inflammation and tissue damage/dysfunction to gain insight into this complex response in mice. We sought to increase the fidelity of our mathematical model and to establish a platform... | 19,008,782 |
Simvastatin reduces endotoxin-induced nuclear factor kappaB activation and mortality in guinea pigs despite lowering circulating low-density lipoprotein cholesterol. | Statins, which are effective lipid-lowering drugs, also possess anti-inflammatory potential. However, circulating lipoproteins may also play a protective role during acute inflammatory diseases because of their ability to bind bacterial toxins. Low cholesterol levels have been reported in inflammatory conditions, and p... | 19,008,785 |
[Megalencephalic leukoencephalopathy with subcortical cysts (van der Knaap disease)]. | A history of the discovery, hypotheses of the pathogenesis, neuromorphologic data, clinical appearances, differential diagnostics and an own description of a single case of rare hereditary children leukoencephalopathy, with megalencephaly, changes of myelin structure and formation of subcortical cysts are presented. Ta... | 19,008,793 |
[Effects of the anticholinesterase drug neuromidin in patients with schizophrenia with marked neurocognitive deficits]. | An objective of the study was to investigate the effectiveness of neuromidin in stable schizophrenic patients with predominance of symptoms of pseudoorganic deficits. Fifty-five patients stable after a transition from routine medication to monotherapy with risperidone were randomized into two groups with add-on placebo... | 19,008,797 |
[Clinical-metabolic data base on chronic generalized parodontitis]. | As the result of clinical-lab study of 40 oral fluid parameters in 176 patients new block of data was received disclosing key pathogenetic links of chronic generalized parodontitis (CGP) to which could be attributed endocrine dysfunction with cortisol level reduction and free thyroid hormones increase, enforcing prooxi... | 19,008,822 |
[Adequacy analysis of bacteriological studies of pyo-inflammatory diseases of ENT organs with fatal outcome]. | Results of analysis of the case history patients that died from complications of pyo-inflammatory diseases of ear, nose, and throat in multifield hospitals of Moscow during the last 10 years are presented. Data of microbiological studies for the entire period of each patient's stay in the hospitals are extracted They i... | 19,008,838 |
[New possibilities for the treatment of pharyngeal and tracheal stenoses following resection of an organ and laryngectomy in patients with disseminated laryngeal and laryngopharyngeal cancer]. | Results of the treatment of 174 patients with stenosis of larynx and trachea by conservative, surgical, and endoscopic methods at different periods after operation indicate that application of novel endoscopic and physical techniques substantially extends possibilities for the low-invasive correction of postoperative l... | 19,008,841 |
Impediment of E. coli UvrD by DNA-destabilizing force reveals a strained-inchworm mechanism of DNA unwinding. | Escherichia coli UvrD is a non-ring-shaped model helicase, displaying a 3'-5' polarity in DNA unwinding. Using a transverse magnetic tweezer and DNA hairpins, we measured the unwinding kinetics of UvrD at various DNA-destabilizing forces. The multiform patterns of unwinding bursts and the distributions of the off-times... | 19,008,855 |
N-6 from different sources protect from metabolic alterations to obese patients: a factor analysis. | First, to analyze the interactions among fatty acids (FAs) from diet, plasma and subcutaneous and visceral adipose tissue (AT), and second, the relationship among FAs from these different sources and obesity-related alterations in extreme obesity. We studied 20 extreme obese subjects. A food-frequency questionnaire was... | 19,008,865 |
BMI compared with central obesity indicators as a predictor of diabetes incidence in Mauritius. | The aim of the study was to compare BMI with waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-stature ratio (WSR) as a predictor of diabetes incidence. A total of 1,841 men and 2,104 women of Mauritian Indian and Mauritian Creole ethnicity, aged 25-74 years, free of diabetes, hypertension, cardiovascula... | 19,008,866 |
Super-shedding and the link between human infection and livestock carriage of Escherichia coli O157. | Cattle that excrete more Escherichia coli O157 than others are known as super-shedders. Super-shedding has important consequences for the epidemiology of E. coli O157 in cattle--its main reservoir--and for the risk of human infection, particularly owing to environmental exposure. Ultimately, control measures targeted a... | 19,008,890 |
The curious case of the tumour virus: 50 years of Burkitt's lymphoma. | Burkitt's lymphoma (BL) was first described 50 years ago, and the first human tumour virus Epstein-Barr virus (EBV) was discovered in BL tumours soon after. Since then, the role of EBV in the development of BL has become more and more enigmatic. Only recently have we finally begun to understand, at the cellular and mol... | 19,008,891 |
Galectin-1 promotes basal and kainate-induced proliferation of neural progenitors in the dentate gyrus of adult mouse hippocampus. | We examined the expression of galectin-1, an endogenous lectin with one carbohydrate-binding domain, in the adult mouse hippocampus after systemic kainate administration. We found that the expression of galectin-1 was remarkably increased in activated astrocytes of the CA3 subregion and dentate gyrus of the hippocampus... | 19,008,923 |
Massive hemorrhage in pregnancy caused by a diffuse cavernous hemangioma of the rectum--EUS as imaging modality of choice. | Hemorrhoidal bleeding is common during pregnancy. Other preexisting anorectal conditions can also be exacerbated by the increased vascular volume and pelvic congestion. We present the case of a young woman who developed life-threatening rectal bleeding requiring early delivery. Through use of endorectal endoscopic ultr... | 19,008,968 |
Minilaparotomy removal of giant gastric trichobezoar in a female teenager. | While small gastric trichobezoars may be removed via gastroscopy, large trichobezoars require surgical removal by gastrotomy through abdominal incision. We present a case of a successful minilaparotomy removal of a giant (2500-g) gastric trichobezoar in a 15-year-old girl with marginal psychological disturbances. | 19,008,981 |
Recognizing nonadherence in patients with multiple sclerosis and maintaining treatment adherence in the long term. | Patients with multiple sclerosis (MS) face many challenges. One significant challenge is long-term adherence to disease-modifying therapy (DMT). Four of the 6 currently available DMTs involve self-injection, and all cause adverse events of varying degrees of severity. Although effective, the benefit of DMTs is difficul... | 19,008,986 |
Epidemiology of kidney cancer. | Some tumors are known to have a definite cause-effect etiology, but renal cell carcinoma (RCC) is not one of them precisely. With regard to RCC we can only try to identify some clinical and occupational factors as well as substances related to tumorigenesis. Smoking, chemical carcinogens like asbestos or organic solven... | 19,009,036 |
PPARalpha/gamma-Independent Effects of PPARalpha/gamma Ligands on Cysteinyl Leukotriene Production in Mast Cells. | Peroxisome proliferator-activated receptor (PPAR) alpha ligands (Wy-14,643, and fenofibrate) and PPARgamma ligands (troglitazone and ciglitazone) inhibit antigen-induced cysteinyl leukotriene production in immunoglobulin E-treated mast cells. The inhibitory effect of these ligands on cysteinyl leukotriene production is... | 19,009,039 |
Genetic counseling in renal masses. | All urologists have faced patients suffering a renal cancer asking for the occurrence of the disease in their offspring and very often the answer to this question has not been well founded from the scientific point of view, and only in few cases a familial segregation tree is performed. The grate shift seen in the dete... | 19,009,041 |
Dip-pen nanolithography and SERRS as synergic techniques. | We demonstrate the powerful combination of dip-pen nanolithography (DPN) performed on non-flat plasmonic gold surfaces and subsequent detection by surface enhanced resonance Raman scattering (SERRS). | 19,009,064 |
Mononuclear Ti[triple bond]N complexes formed by the facile multiple deprotonation of H3N x B(C6F5)3: the importance of chloride ligands. | The crystalline ion-pair [TiCl(NMe(2))(2)(NMe(2)H)(2)](+)[TiCl(2){NB(C(6)F(5))(3)}(NMe(2)H)(2)](-), in which the anion has a triply bonded nitridoborate ligand, is formed through the multiple activation of H(3)N x B(C(6)F(5))(3) when treated with [Ti(NMe(2))(3)Cl]. | 19,009,078 |
Exploiting the natural metabolic diversity of Streptomyces venezuelae to generate unusual reduced macrolides. | An unusual set of reduced macrolide antibiotics was discovered by combination of organic synthesis and a biosynthetic approach using the unique metabolic diversity of Streptomyces venezuelae; two unnatural 16-membered ring macrolides are also created by employing this bio-catalyst. | 19,009,080 |
Polyfunctional benzylic zinc chlorides by the direct insertion of magnesium into benzylic chlorides in the presence of LiCl and ZnCl2. | Benzylic zinc chlorides bearing various functional groups are smoothly prepared by the direct insertion of magnesium into benzylic chlorides in the presence of LiCl and ZnCl(2). | 19,009,094 |
[Leprosy: control of household contacts in the municipality of Londrina-PR for a ten-year period]. | The purpose of this descriptive study is to analyze variables related to leprosy patients' household contacts who received treatment in Londrina-PR-Brazil for a ten-year period. The data analysis was based on the health service's records and from a system of infectious disease. Out of 1055 leprosy's patients, it was re... | 19,009,109 |
[Leprosy social mobilization workshop: an experience report]. | The aim of the present study was to describe the report of the experience of a Social Mobilization and Theoretical Approach to Leprosy workshop among nursing academics. As methodology it was used the experience of the referred workshop amongst the three stages of its accomplishment, the main topics which stood out were... | 19,009,121 |
[Fertility of indigenous women in Minas Gerais State, Brazil: an analysis using the 2000 census]. | Indigenous populations living in villages in Brazil have presented high total fertility rates (TFR) that have increased over time in some cases. Meanwhile, data from the Brazilian Institute of Geography and Statistics (IBGE) or National Census Bureau show a decline in the TFR for the total self-declared indigenous popu... | 19,009,128 |
Vulnerability and non-adherence to antiretroviral therapy among HIV patients, Minas Gerais State, Brazil. | The aim of the present study was to describe vulnerability profiles and to verify their association with non-adherence to antiretroviral therapy (ART) among 295 HIV-patients receiving their first prescription in two public-referral centers in Minas Gerais States, Brazil. The cumulative incidence of non-adherence was 36... | 19,009,140 |
[Bayesian model for the risk of tuberculosis infection for studies with individuals lost to follow-up]. | To develop a statistical model based on Bayesian methods to estimate the risk of tuberculosis infection in studies including individuals lost to follow-up, and to compare it with a classic deterministic model. The proposed stochastic model is based on a Gibbs sampling algorithm that uses information of lost to follow-u... | 19,009,157 |
Evaluation of prescription of exercise, for rehabilitation of coronary artery disease patients by myocardial scintigraphy. | It is advisable that the intensity of the exercises for rehabilitation of patients with coronary artery disease does not cause myocardial ischemia. Compare the capacity of myocardial tomographic scintigraphy with the electrocardiogram capacity in ischemia detection during rehabilitation session. Twenty six patients wit... | 19,009,174 |
[Competition between Aedes aegypti and Aedes albopictus larvae in the laboratory]. | This study had the aim of evaluating the effects of intra and interspecies larval competition between Aedes aegypti and Aedes albopictus, survival of larvae time taken to develop and wing length. The experiment was carried out with three densities and five proportions of the species. Aedes aegypti survival was greater ... | 19,009,190 |
[Effect of larval rearing water on Aedes aegypti oviposition in the laboratory]. | To evaluate the influence of larval rearing water on Aedes aegypti oviposition, four types of water were provided for gravid females. It was observed that more eggs were laid in the mixed larval rearing water (2,837) than in the Aedes albopictus water (690) or control water (938), but that this number was similar to wh... | 19,009,198 |
[Isoenzymatic characterization of human isolates of Leishmania sp (Kinetoplastida: Trypanosomatidae) from the municipalities of Rio Preto da Eva and Manaus, State of Amazonas]. | Twenty-three isolates of Leishmania sp from patients in the municipalities of Rio Preto da Eva and Manaus were characterized and identified by means of isoenzyme electrophoresis and the degree of similarity between the organisms was analyzed. The results indicated that Leishmania guyanensis and Leishmania naiffi were p... | 19,009,197 |
Inhibition of migration and invasion of colorectal cancer cells via deletion of Rac1 with RNA interference. | Cell migration and invasion are triggered by a number of chemoattractants that stimulate intracellular signaling pathways through regulating reorganization of the actin cytoskeleton. Rac1, an intracellular signal transducer, regulates a variety of cell functions, including the organization of the cytoskeleton, cell mig... | 19,009,236 |
Detection and quantification of serum or plasma HCV RNA: mini review of commercially available assays. | The treatment schedule (combination of compounds, doses, and duration) and the virological follow-up for management of antiviral treatment in patients chronically infected by HCV is now well standardized, but to ensure good monitoring of the treated patients, physicians need rapid, reproducible, and sensitive molecular... | 19,009,249 |
Structural and functional analysis of the HCV p7 protein. | The p7 membrane polypeptide from HCV is essential for virus infection. It exhibits ion-channel activity reported to be specifically blocked by various compounds. These properties make p7 an attractive candidate target for antiviral intervention to combat viral hepatitis C infection. In this context, in vitro functional... | 19,009,258 |
Studying HCV cell entry with HCV pseudoparticles (HCVpp). | HCV infection leads in 50 to 80% of cases to chronic hepatitis, liver cirrhosis, or hepatocellular carcinoma. Interferons and the nucleoside analog ribavirin form the basis for treatment but are not sufficiently effective and have numerous side effects. Although about 300 million people worldwide are estimated to be in... | 19,009,269 |
Selectivity for glucose, glucose-6-phosphate, and pyruvate in ternary mixtures from the multivariate analysis of near-infrared spectra. | Near-infrared spectroscopy offers the potential for direct in situ analysis in complex biological systems. Chemical selectivity is a critical issue for such measurements given the extent of spectral overlap of overtone and combination spectra. In this work, the chemical basis of selectivity is investigated for a set of... | 19,009,286 |
MAP2-mediated in vitro interactions of brain microtubules and their modulation by cAMP. | Microtubule-associated proteins (MAPs) are involved in microtubule (MT) bundling and in crossbridges between MTs and other organelles. Previous studies have assigned the MT bundling function of MAPs to their MT-binding domain and its modulation by the projection domain. In the present work, we analyse the viscoelastic ... | 19,009,287 |
Ribosomal ITS sequences allow resolution of freshwater sponge phylogeny with alignments guided by secondary structure prediction. | Freshwater sponges include six extant families which belong to the suborder Spongillina (Porifera). The taxonomy of freshwater sponges is problematic and their phylogeny and evolution are not well understood. Sequences of the ribosomal internal transcribed spacers (ITS1 and ITS2) of 11 species from the family Lubomirsk... | 19,009,316 |
One thousand laparoscopic cholecystectomies in a single surgical unit using the "critical view of safety" technique. | Bile duct injuries have been substantially increased after the introduction of laparoscopic cholecystectomy (LC). They are accompanied by major morbidity, occasional mortality, lengthening of hospital stay, additional health costs, and deterioration of patients' quality of life and life expectancy. The aim of this stud... | 19,009,323 |
Altered heart rate control in response to postural change in patients with Machado-Joseph disease (SCA3). | To assess heart rate (HR) regulation in Machado-Joseph disease (MJD), we evaluated HR variability at rest and the initial HR response to standing suddenly in 13 MJD patients and 26 normal control subjects. A head-up tilt (HUT) test involving the monitoring of blood pressure, HR, and cerebral oxy/deoxyhemoglobin concent... | 19,009,326 |
Scrub typhus as a possible aetiology of Guillain-Barré syndrome: two cases. | Neurological complications of scrub typhus are reported to be rare. Peripheral nervous system involvement has been reported in only one case. We present two cases of Guillan-Barré syndrome (GBS) associated with scrub typhus. In both cases, the findings of an elevated indirect immunofluorescent antibody titer for Orient... | 19,009,332 |
Decomposing group differences of latent means of ordered categorical variables within a genetic factor model. | A genetic factor model is introduced for decomposition of group differences of the means of phenotypic behavior as well as individual differences when the research variables under consideration are ordered categorical. The model employs the general Genetic Factor Model proposed by Neale and Cardon (Methodology for gene... | 19,009,342 |
Effect of burn injury on apoptosis and expression of apoptosis-related genes/proteins in skeletal muscles of rats. | The purpose of this study was to investigate the occurrence and possible mechanisms of apoptosis in skeletal muscles after burn injury. After a 40% body surface area burn to rats, TA muscles were examined for apoptosis at varying times by TEM, TUNEL and cell death ELISA assay. Thermal injury was found to induce apoptos... | 19,009,350 |
Degradation pathway of an anthraquinone dye catalyzed by a unique peroxidase DyP from Thanatephorus cucumeris Dec 1. | The reactants produced by action of a purified unique dye-decolorizing peroxidase, DyP, on a commercial anthraquinone dye, Reactive Blue 5, were investigated using electrospray ionization mass spectrometry (ESI-MS), thin-layer chromatography (TLC), and (1)H- and (13)C- nuclear magnetic resonance (NMR). The results of E... | 19,009,358 |
Distribution of volatile organic compounds in Madrid (Spain). | From November 1995 to October 1996, airborne concentrations of VOCs were measured in the Madrid area to study the organic pollution in general, and the correlation between different pollutants in relation to such parameters as location and season. Mean concentrations for up to 90 compounds were measured at four test si... | 19,009,389 |
Measurements of selected PCBs in open urban ambient air of Madrid (Spain): First results. | The focus of this study was to characterize the concentration levels of selected PCBs and compare them to compiled data in order to contribute to the international database. The sampling site is located in the outskirts of Madrid and can be considered an open urban area. 32 samples of air were taken from February 1998 ... | 19,009,391 |
Soil-atmosphere exchange of radiatively and chemically active gases. | Exchanges between the soils and the atmosphere may control or significantly affect the global budgets of many environmentally important trace gases, both natural and man-made. Flux measurements, taken in several ecosystems, show that soils are a substantial source of chloroform (8 +/- 4 microg/m(2)/d) and a sink for me... | 19,009,426 |
The war in Kosovo: Evidence of pollution transport in the Balkans during operation "Allied Force". | During the operation "Allied Force" in the spring of 1999, the burning or damaging of industrial and military targets in the Former Republic of Yugoslavia resulted in the release of a large number of chemicals into the atmosphere. The releases contained not only conventional air pollutants, but also Semi-Volatile Organ... | 19,009,430 |
Multidimensional risk analysis of antifouling biocides. | In order to improve the orientation about the long-term sustainability of the use of the antifouling biocides tributyltin (TBT), copper, Irgarol 1051, Sea-Nine 211 and zinc pyrithione, used for the protection of fouling in sea-going ships, the risks posed to the marine biosphere due to their use are evaluated. The newl... | 19,009,431 |
GM Risk Assessment. | GM risk assessments play an important role in the decision-making process surrounding the regulation, notification and permission to handle Genetically Modified Organisms (GMOs). Ultimately the role of a GM risk assessment will be to ensure the safe handling and containment of the GMO; and to assess any potential impac... | 19,009,454 |
Pain among veterans with spinal cord injury. | The Department of Veterans Affairs Veterans Health Administration cares for approximately 15% of persons with spinal cord injury (SCI) in the United States. However, the nature and characteristics of pain among veterans with SCI are not well understood. This study used a postal survey to compare veterans with SCI and n... | 19,009,466 |
Effect of model design, cushion construction, and interface pressure mats on interface pressure and immersion. | Measuring interface pressure (IP) is one way to characterize cushion performance in the clinic and laboratory. This study explored how the presence of four commercially available IP mats affected IP on and immersion of two buttocks models. We loaded seven cushions with each buttocks model and captured pressure data usi... | 19,009,473 |
Models of reading performance in older adults with normal age-related vision. | Reading rate with print size (reading performance) was studied in a group of 132 older readers with normal age-related vision using the Minnesota Low Vision Reading Acuity (MNREAD) test. Regression by a monotonic Weibull model had greater convergence success with lower residual error than either Logistic or Gompertz mo... | 19,009,476 |
Effect of streptozotocin-induced diabetes mellitus on the pharmacokinetics of nelfinavir in rats. | The HIV protease inhibitor, nelfinavir (NFV), has been used widely for HIV infection. The drug exhibits high binding characteristics to serum protein (unbound fraction: 0.01). The effect of experimentally induced diabetes mellitus on the pharmacokinetics of NFV was investigated, focusing on the change of protein-bindin... | 19,009,515 |
Infrared laser desorption/vacuum ultraviolet photoionization mass spectrometry of petroleum saturates: a new experimental approach for the analysis of heavy oils. | A novel method combining infrared (IR) laser desorption with tunable synchrotron vacuum ultraviolet (VUV) photoionization mass spectrometry (LD/VUV PIMS) is applied to characterize a number of petroleum saturates samples from Lungu atmospheric residue (LGAR) under different treatment procedures. The mass spectra of the... | 19,009,521 |
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