title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Corman loyal to universal NHI program. | Rep. James C. Corman has swung his support to the President's plan for national health insurance but still prefers universal public health care coverage. | 376,426 | [
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The structural proteins and glycoproteins of herpesviruses: a review. | The virions of different herpesviruses are similar with respect to the number and kinds of constituent polypeptides, in spite of variability in the structures of individual polypeptides. The total number of virion polypeptides and glycopeptides ranges from 20 to 30 for different viruses and, in general, no more than on... | 376,432 | [
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Cocaine: magical drug or menace? | Cocaine has attracted much attention as a recreational drug and some advocates have acclaimed it as both pleasurable and safe. This paper reviews the available evidence concerning the drug's physiological and psychological safety. Few deaths are attributed to cocaine, but its use is presently restricted by very limited... | 376,450 | [
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Fluorescence microscopy for detection of M. leprae in tissue sections. | The fluorescence method was compared with the Fite-Faraco method for detecting acid-fast microorganisms in paraffin sections of cases of leprosy. Biopsies were obtained from 50 cases of leprosy covering all varieties and at varying stages of treatment. The fluorescence method was better than the Fite-Faraco method; 22 ... | 376,453 | [
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Identification of regions of pRZ2 which have delayed elution behavior on RPC-5 column chromatography. | DNA restriction fragments generally elute from RPC-5 in order of their size. However, some fragments elute later than predicted. Chromatographic studies were performed on five different restriction digests (Hae III, Hha I, Alu I, Taq I, and Hae III + HindII) of pRZ2 DNA in an effort to localize the regions which have t... | 376,512 | [
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The functional relationship between priming and releasing actions of luteinizing hormone-releasing hormone. | To examine the relationship between the priming and releasing actions of LRF on LH secretion, 14 normal cycling women received 4 different rates of LRF infusion (0.005, 0.01, 0.05, and 0.1 microgram/m2.min for 4 h). The releasing action of the infusion was measured as the area under the curve and the priming effect was... | 376,545 | [
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Antigenic modulation and turnover in human neutrophils. | Turnover of membrane constituents appears important in many biologic processes. We studied this process in neutrophils by immunologic methods. The capacity of neutrophils to recognize other neutrophils coated with antibodies against membrane antigens was used to determine the changes that occur after attachment of the ... | 376,559 | [
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Horseradish peroxidase labeled antisera--a diagnostic method for evaluating the percentages of B lymphocytes in peripheral blood. | Horseradish peroxidase labeled antisera supplied commercially was used to evaluate B lymphocytes in peripheral blood. This technique not only gave comparable results to the conventional fluorescein method, but also proved to be more advantageous. | 376,687 | [
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Serotypes of antibiotic resistant Escherichia coli isolated from the sewage of Palmerston North (New Zealand). | Antibiotic resistant strains of Escherichia coli were isolated from the domestic sewage of Palmerston North. The ability of these strains to transfer the drug resistance markers to two different recipient E. coli strains was assessed. The 'O' and 'H' serotypes of all strains were determined and attempts at correlation ... | 376,697 | [
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Immunoadjuvant treatment of primary grafted and spontaneous AKR-leukemia. I. Treatment efficiency correlated to autoimmune reactivity. | Young AKR mice grafted i.v. with 10(1) or 10(3) cells from spontaneous AKR thymomas were treated with repeated i.v. injections of BCG or subcutaneous injections of irradiated AKR thymoma cells. BCG often cured mice from graft leukemia, whereas the effect of irradiated thymoma cells was less effective. Mice that did not... | 376,705 | [
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Further studies on the activation of lymphocytes by endotoxin protein. | Endotoxin protein, an outer membrane protein of Gram-negative bacteria associated with lipopolysaccharide endotoxin, has been found to be a potent activator of lymphocytes. In the absence of T lymphocytes and macrophages, endotoxin protein can stimulate murine B lymphocytes to synthesize DNA and produce antibodies of d... | 376,715 | [
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Expression of MHC antigens by mouse thymic dendritic cells. | Thymic epithelial cells express MHC antigens in several different patterns. I-A is present throughout the thymic cortex on dendritic cells. The remainder of the I region and H-2K/D are expressed on dendritic cells apparently only variably in the cortex (at least in some haplotypes). All MHC antigens tested are present ... | 376,735 | [
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A quantitative assay for low levels of IgM by solid-phase immunofluorescence. | A quantitative immunofluorescent assay capable of detecting between 15 and 1450 ng of IgM on a strictly linear standard curve has been developed. The assay system is unique in that in vitro biosynthesized polyclonal IgM in culture supernatants can be quantitated with a minimal quantity of supernatant. Interference crea... | 376,748 | [
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Exfoliative cytological procedures as a nonintrusive method for dermatogerontological studies. | Exfoliative cytological procedures, based on the sticky slide and detergent scrub techniques, were used in the nonintrusive collection of horny cells from the skin surface of volunteers 20 to 30 yr of age and 65+ yr of age. These samples were analyzed with a variety of instruments, including a Magiscan image analyzer, ... | 376,755 | [
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Prevention of colonization of the urinary tract of mice with Escherichia coli by blocking of bacterial adherence with methyl alpha-D-mannopyranoside. | Methyl alpha-D-mannopyranoside (alpha MM), a competitor inhibitor of the binding of mannose by Escherichia coli, was tested for its ability to prevent infection of the urinary tract of mice with infective strains of the organisms. Injection of the bacteria in the presence of the drug resulted in a considerable reductio... | 376,757 | [
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Experimental viral infections of the temporal bone. I. Experimental otitis media due to vaccinia virus in hamsters. | Clinical and pathologic studies of patients with smallpox suggest that conductive hearing loss is a frequent complication of smallpox and that it is due to otitis media. A possible experimental model for this hearing loss has been developed by study of the pathogenesis of acute vaccinia virus infections of hamster midd... | 376,758 | [
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NCTR computer systems designed for toxicologic experimentation. III. Breeding information system. | The Breeding Information System (BIS) facilitates management control of the breeding colony operation at the National Center for Toxicological Research (NCTR). Although this automated data handling system was initially intended to support Animal Husbandry the system's basic design, flexibility or reporting, data manipu... | 376,771 | [
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Agreement measurement and the judgment process. | This paper reviews the rationale for correcting for chance agreement beween two raters. It is suggested that under certain conditions correction for chance agreement is both unnecessary and inappropriate. When a chance correction is indicated, the chosen measure should be one that can be shown to be logically in accord... | 376,781 | [
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Composition of isolated edema fluid in cold-induced brain edema. | Edema fluid isolated from cats with cold-induced brain edema was subjected to analysis of electrolyte content, enzyme activities, colloid osmotic pressure and the radioactivity of intravenously injected 99mTc-labeled albumin. The findings corroborate the essential features of vasogenic edema, such as its origin from th... | 376,787 | [
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Association of autoantibodies with anemia, splenomegaly, and glomerulonephritis in experimental African trypanosomiasis. | Rats experimentally infected with Trypanosoma brucei rhodesiense developed a syndrome characterized by anemia, splenomegaly, and glomerulonephritis. Serologic evaluation revealed that the syndrome was accompanied by the presence of 3 autoantibodies--cold-active hemagglutinin, immunoconglutinin, and antibody to fibrinog... | 376,815 | [
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Ultrastructure of the rectum of infective-stage Wuchereria bancrofti (Nematoda: Filarioidea). | The authors have examined the ultrastructure of the rectum of infective-stage Wuchereria bancrofti by transmission electron microscopy. Our observations show that the rectum is divided into anterior and posterior segments. The cells of the anterior rectum appear to be derived from the microfilarial R (rectal) cells des... | 376,820 | [
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[The South African Army Veterinary Services]. | The history of the South African Military Veterinary Services is outlined from the time the first veterinarian, Thomas Burrowes, attached to the 8th Light Dragoons, set foot in the Cape in 1799, until the end of World War II. It summarises the extensive literature published mainly by Curson in previous issues of this J... | 376,839 | [
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Dipeptides of O-methyl-L-threonine as potential antimalarials. | L-Leucyl-O-methyl-L-threonine, O-methyl-L-threonyl-L-leucine, and O-methyl-L-threonyl-O-methyl-L-threonine were prepared and compared with O-methyl-L-threonine and L-leucine for antimalarial activity against Plasmodium berghei in mice. O-Methyl-L-threonine significantly prolonged survival time at doses of 160, 320, and... | 376,849 | [
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Inhibition of anion permeability by amphiphilic compounds in human red cell: evidence for an interaction of niflumic acid with the band 3 protein. | In human erythrocyte, permeability to the anion is instantaneously, reversibly, and noncompetitively inhibited by the nonsteroidal anti-inflammatory drug, niflumic acid. The active form of this powerful inhibitor (I50 = 6 X 10(-7) M) is the ionic form. We demonstrated that: (i) The binding of niflumic acid to the membr... | 376,851 | [
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The significance of changes in the nasal mucosa in indeterminate, tuberculoid and borderline leprosy. | A study of nasal biopsies from 137 leprosy patients classified on the basis of clinical, microbiological and skin biopsy as Indeterminate, Tuberculoid, Borderline-tuberculoid and Borderline-leproma was undertaken. Changes suggestive of leprosy viz., nerve and smooth muscle inflammation with a few acid fast bacilli in a... | 376,945 | [
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Dissociation of the effects of nicotinic acid on vasodilatation and lipolysis by a prostaglandin synthesis inhibitor, indomethacin, in man. | The effects of nicotinic acid on plasma free fatty acid (FFA) concentration and forearm blood flow were studied in seven healthy fasting volunteers with and without pretreatment by indomethacin to see if some effects of nicotinic acid are mediated by release of endogenous prostaglandin. 1 g of nicotinic acid per os dec... | 376,964 | [
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[Mathematical model of tryptophan synthesis and excretion into the environment by E. coli cells]. | A quantitative kinetic model is suggested for the auto-regulated tryptophan synthesis by E. coli trp-operon system and for tryptophan excretion from the cell mediated by transport systems. Applications of the model for the calculation of several parameters characterizing tryptophan metabolism are considered. In order t... | 377,049 | [
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A correlative study of immunofluorescence, electron, and light microscopy in immunologically mediated renal tubular disease in man. | Renal biopsy specimens obtained from patients with various chronic nephropathies were studied by immunofluorescence (IF), electron and light microscopy. Of 49 biopsies studied by IF, 22 had granular deposits of IgG and/or C3 along the basement membranes of proximal tubules while 14 had linear and 13 both linear and gra... | 377,110 | [
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0.0308453,
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0.1177531,
0.003459956,
-0.002947367,
-0.037195... |
Valproic acid and plasma levels of phenytoin. | Eight patients were treated concurrently with a constant dose of phenytoin and valproic acid for 1 year. During initial therapy with valproic acid, total plasma phenytoin levels decreased. The interaction was transient and was not observed at the end of 1 year. Total plasma phenytoin levels returned to pre-valproic-aci... | 377,134 | [
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C-peptide response to glucagon in diabetics with and without complications. | Beta cell function has been studied by measurement of C-peptide responses to intravenous glucagon in 11 diabetics with advanced complications and compared with nine long-term diabetics without complications. The majority had no C-peptide responses, but there was evidence of beta cell function in one patient from each g... | 377,156 | [
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Recurrent nonimmune hydrops fetalis. | A case of recurrent nonimmune hydrops fetalis is presented. In each of the 2 pregnancies involved, early neonatal death occurred. Only 1 other case could be discovered in the literature where the problem recurred. Hence, normally, a good prognosis for future pregnancies is given. In spite of extensive investigation, th... | 377,163 | [
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Fetal swallowing and voiding in relation to hydramnios. | Fetal swallowing and voiding were measured using colloidal gold and an ultrasonic scanner, respectively. Subjects in the study were in their 38-40th week of pregnancy. Cases were divided into 3 groups: normal, hydramnios, and oligohydramnios. The normal group had a mean swallowing rate of 198 ml/day and a mean voiding ... | 377,164 | [
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0.1010437,
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Gracilis myocutaneous flap in reconstruction of the vulva and female perineum. | For the past 2 decades there has been a definite trend among pelvic surgeons to immediately reconstruct the large defects created by deforming radical cancer surgery in the female pelvis and perineum. Extensive en bloc removal of more tissue has enhanced the probabilities of increased 5-year survival. At the same time,... | 377,166 | [
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Liver replacement for pediatric patients. | Between March 1963 and January 1978, 74 patients 18 years of age or younger have had liver replacements at the University of Colorado Medical Center, Denver. The most common cause of native liver failure was biliary atresis (48/74, 65%); the second most common cause was chronic aggressive hepatitis (12/74, 16%). Twenty... | 377,201 | [
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Body-cathexis and self-cathexis in an interactional, awareness training class. | This study examined the effects of a psychology of adjustment class on body-acceptance and self-acceptance. An introductory psychology class served as a control group. Subjects were pre- and posttested with the Body-cathexis and Self-cathexis scales. Two by two analyses of covariance indicated that the adjustment group... | 377,211 | [
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Monaural studies eliciting an hemispheric asymmetry: a bibliography. | Since 1967, 74 studies reported in the literature using monaural stimulation elicited an hemispheric asymmetry, confirming original findings from dichotic listening studies. | 377,212 | [
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[Materno-foetal transfer of anti-HLA antibodies. Study by using LDA test (author's transl)]. | The LDA test was used to study the materno-foetal transfer of anti-HLA antibodies. The results were compared with those obtained earlier by the complement dependent lymphocytoxicity test (CdL). Although more sensitive than CdL, the LDA test did not demonstrate more maternal antibodies in cord blood when these antibodie... | 377,226 | [
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The regulatory region of MS2 phage RNA replicase cistron. IV. Functional activity of specific MS2 RNA fragments in formation of the 70 S initiation complex of protein biosynthesis. | The initiation region of the MS2 replicase cistron can be isolated as a fragment 59 bases in length protected from RNAase by the binding of the coat protein which serves as a translational repressor. This fragment MS2 R(-53 leads to 6) starts 53 bases before the initiation codon and retains full activity in binding rib... | 377,230 | [
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Physical map of the seven ribosomal RNA genes of Escherichia coli. | Escherichia coli DNA was digested with restriction endonucleases BamHI, PstI, EcoRI, SalI, HindIII, XhoI, BglII, SmaI, HpaI and with selected double and triple combinations of the same enzymes. The digests were electrophoresed and hybridized with 32P-labelled ribosomal RNA by using the Southern blotting technique. The ... | 377,232 | [
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Monovalent ionophores inhibit secretion of procollagen and fibronectin from cultured human fibroblasts. | Procollagen and fibronectin are major products of confluent fibroblasts in culture and both are released from the cells. Procollagen is secreted by known pathways, while the mechanism of fibronectin release is controversial. We find that the secretion of both these proteins can be reduced to 20% by low concentrations (... | 377,287 | [
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Healing of microvascular arterial anastomoses, as seen on corrosion casts by scanning electron microscopy. | We made 44 microsurgical anastomoses in the femoral artery in rats. The healing was studied from one day to 4 months, by making an acrylic cast of the lumen of the femoral artery and the surrounding vessels, and examining the cast by scanning electron microscopy. The method proved to be easy and relatively quick, and i... | 377,331 | [
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Alternatives to subcutaneous mastectomy. | It is our belief that subcutaneous mastectomy often leads to complications, with poor results. In addition, because a considerable amount of breast tissue may be left behind, its value as a prophylactic operation must be questioned. Two alternatives are presented. In our experience, these lead to fewer complications wi... | 377,340 | [
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A double-blind study of erbium169 synoviorthesis in rheumatoid digital joints. Results after one year. | A double-blind study was made on the effectivenss of erbium169 synoviorthesis in the digital joints of 7 patients with erosive, seropositive rheumatoid arthritis. The study involved 70 joints observed over a 12-month period: 20 pairs of metacarpophalangeal joints (MCP) and 15 pairs of proximal interphalangeal joints (P... | 377,476 | [
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Permeability of the cell-to-cell membrane channels in mammalian cell juncton. | The channels in the junctions of various mammalian cell types--primary cultures and lines--were probed with a series of linear fluorescent amino acid and peptide molecules of different size and charge. Permeability is limited by probe size and electronegativity, these two factors apparently being related reciprocally. ... | 377,490 | [
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Heparin neutralization of PGI2: effects upon platelets. | Heparin neutralizes the inhibitory effect of prostacyclin (PGI2) on platelet aggregation. The PGI2-induced enhancement of platelet cyclic adenosine monophosphate levels is also inhibited. The mechanism appears to involve a direct interaction in which heparin neutralizes the inhibitory effects of PGI2 on platelet aggreg... | 377,493 | [
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Metabolic alkalosis complicating weaning from mechanical ventilation. | Metabolic alkalosis was identified and confirmed as a precipitator of acute hypercapnea. As a result, weaning from mechanical ventilator therapy was delayed. Correction of alkalosis followed by reduction of PCO2 confirmed the compensatory mechanism during alkalosis, and weaning from intermittent mandatory ventilation t... | 377,506 | [
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Considerations in the choice of surgical needles. | Bodily tissues of varying consistency, thickness, penetrability, location and weave are encountered by the surgeon. Correspondingly, he should choose surgical needles that will introduce sutures through these tissues in the most precise and rapid manner, ideally creating a wound just large enough to draw the suture mat... | 377,531 | [
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Past, present, and future aspects of histocompatibility. | We have stressed problems attendant on studies of the MHC, ignoring non-HLA factors and their role in allograft immunity. Many other topics could have been chosen for discussion is any such overview; our selection reflects our own interests. We felt assured, however, that excellent coverage by our many colleagues of th... | 377,618 | [
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Cryopreserved autologous bone marrow transplantation in the treatment of selected pediatric malignancies: a preliminary report. | We have shown that it is possible to collect and viably store sufficient numbers of stem cells to hematologically reconstitute patients following marrow-lethal doses of chemoradiotherapy. While no current procedure can be guaranteed to eliminate clonogenic tumor from the bone marrow, the fact that hematopoietic stem ce... | 377,634 | [
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Heterotopic versus orthotopic heart transplantation. | Since November 1974, heterotopic cardiac transplants have been performed at this unit in preference to orthotopic transplants. A number of reasons have led us to prefer this technique, namely donor malfunction in the immediate postoperative period and during rejection; right ventricular failure of the donor heart in th... | 377,650 | [
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Double blind controlled comparison of aspirin, allopurinol and placebo in the management of arthralgia during pyrazinamide administration. | Chinese patients with arthralgia during treatment with an antituberculosis regimen containing pyrazinamide were allocated at random to 3 anti-arthralgia treatment series in a controlled double-blind study. One series (18 patients) received soluble aspirin 2.4 g daily, the second (23 patients) allopurinol 200 mg daily, ... | 377,739 | [
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[Theoretical grounds for free osteoplasty in suppurative infection]. | From the materials of extensive experimental studies and clinical observations the theoretical grounds for the free bone plasty under the conditions of purulent infection were devised. The methods of investigation of the microcirculatory vascular bed, luminescent microscopy with a tetracycline mark, photometry, planime... | 377,768 | [
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Calcium antagonists and islet function. IX. Is extracellular calcium required for insulin release? | The physiological relevance of extracellular Ca2+ and Mg2+ to the process of glucose-induced insulin release is examined in both the isolated perfused rat pancreas and rat isolated pancreatic islets. When no Ca2+ is added to the perfusion or incubation media, both the initial and late phases of insulin release are seve... | 377,879 | [
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[New viewpoints on the pathogenesis of diabetes mellitus]. | Diabetes mellitus is a syndrome characterised primarily by an increase in blood glucose and an absolute or relative deficiency of insulin. Etiologically, it is a complex disorder because many different genetic, environmental, immunological, metabolic and hormonal influences interact to produce the clinical picture diab... | 377,886 | [
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Small-colony forms of enteric bacteria after exposure to aminoglycosides. | Small colony forms of enteric bacteria were isolated in vitro after exposure of near-lethal amounts of aminoglycosides. These small-colony forms were several times more resistant to all aminoglycosides than the parent clones. A small form of Escherichia coli was isolated directly from a clinical specimen, along with a ... | 377,947 | [
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Emil Heitz and the concept of heterochromatin: longitudinal chromosome differentiation was recognized fifty years ago. | The work of Emil Heitz (1892--1965) laid one of the keystones of cytogenetics. Using a new in situ method, he established between 1928 and 1935 the longitudinal differentiation of chromosomes in euchromatin (genetically active) and heterochromatin (genetically inert). He recognized the association of satellited chromos... | 377,956 | [
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0.006170942,
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0.09684304,
0.1589939,
-0.132997,
... |
The biochemical genetics of the hexosaminidase system in man. | Tay-Sachs disease and related GM2 ganglioside storage disorders result from the absence of one form of hexosaminidase, HEX A. The persistence of a second major hexosaminidase isozyme, HEX B, does not protect against the lethal accumulation of GM2 ganglioside in the central nervous system. Using immunologic and biochemi... | 377,957 | [
-0.1796681,
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0.1567462,
0.1058719,
0.2283696,
0.3621042,
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... |
Optimum dosage of an oral contraceptive. A report from the study of seven combinations of norgestimate and ethinyl estradiol. | A statistically designed study was carried out to determine an optimum combination of norgestimate and ethinyl estradiol as an oral contraceptive, based on efficacy, safety, and side-effect patterns. A total of 1,991 patients were studied for more than two years while they were receiving various dosage combinations of ... | 377,968 | [
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0.1566176,
0.03629213,
0.2489605,
0.06213518,... |
Reconstruction of the medial eyelid. | We used a free tarsal-conjunctival grate from the upper eyelid and a nasal-based pedicle skin-muscle flap for reconstruction of the medial aspect of the lower eyelid. This had the advantage of confining the reconstruction to the local area and eliminated the need for a temporal flap or an eyelid sharing procedure that ... | 377,974 | [
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0.1154947,
0.01363018,
0.1285702... |
Bioblock therapy. | An orthopedic treatment philosophy has been presented. Attention is drawn to the fact that the facial bones of both experimental animals and human beings respond extensively to physiologic and pathologic forces, and it is suggested that these could be mimicked to advantage. A system of appliances designed to achieve th... | 377,988 | [
-0.2913588,
0.1572513,
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0.02087215,
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0.03238548,
0.1822495,
-0.00643736,
-0.0937... |
Intraperitoneal povidone-iodine in experimental canine and murine peritonitis. | In dogs with appendicitis-peritonitis, intraperitoneal povidone-iodine caused death more rapidly than the instillation of saline solution. The bacterial content of canine peritoneal fluid increased with time. Although fewer bacteria were found in fluid from povidone-iodine-treated dogs, the differences were not statist... | 378,012 | [
-0.2647066,
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0.06613909,
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0.135066,
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0.2889471,
-0.1145842,
0.2725145,
0.0929... |
Evaluation of various methods for the detection of enteropathogenic Escherichia coli in diarrheic calves. | Evaluation of the Escherichia coli population in the small intestine of diarrheic calves was performed by estimating the number of colony-forming units and the observation of direct gram-stained smears of mucosal scrapings. Enterotoxigenicity of the isolates was determined by the infant mouse test and the ligated intes... | 378,046 | [
-0.02428458,
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0.1400061,
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0.1191028,
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0.08714063,
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0.1352263,
0.3267809,
0.1230442,
0.0447746... |
Corneal transplantation with associated histopathologic description in xeroderma pigmentosum occurring in a black family. | Three cases of xeroderma pigmentosa in Bantu patients with corneal opacification are presented. The histologic appearances of the corneae following corneal transplantation is given. | 378,083 | [
0.2767551,
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-0.1366071,
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0.05004164,
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0.05976513,
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0.1006615,
0.2954899,
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0.2459802,
0.4051809,
-0.06138655,
... |
Toxic fungi. | Much progress in the areas of identification of active components and elucidation of the toxic mechanisms for the principal poisonous mushrooms has been made in the past decade. This affords a more rational approach to therapeutic management which has consequently resulted in a decrease in the morbidity and mortality a... | 378,111 | [
-0.2305661,
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0.1693618,
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0.1661087,
0.04394951,
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0.1802746,
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0.1588232,
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0.3570218,
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0.3357923,
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0.1469129,
0.331275,
0.1419121,
0.180169,
0.536676,
-0.05587671,
-0.0... |
[Dynamics of the change in sensitivity of shigellae to gentamycin and cephaloridine in vitro]. | The dynamics of the changes in the Shigella sensitivity to gentamicin and cephaloridin was studied in vitro using liquid nutrient media with gradually increasing concentrations of the drugs. 50 passages were performed. It was found that Shigella flexner and sonnei decreased their sensitivity to gentamicin to a little e... | 378,113 | [
0.03637715,
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0.1234412,
0.1459891,
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0.2862131,
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0.4250404,
0.2679882,
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0.3080878,
-0.2461287,
-0.2768518,
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0.08799491,
-0.4679277,
0.1553038,
0.1946335,
-0.005553748,
0.2278017,
-0... |
A simple method for closure of patient ductus arteriosus in elderly patients. | A relatively simple and safe method for closure of the patient ductus arteriosus in the elderly patient is described. It has been done successfully in 4 patients. | 378,144 | [
-0.05573572,
0.1948771,
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-0.1974441,
-0.3960156,
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-0.1978893,
0.00813406,
0.2651585,
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0.1217901,
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0.05777032,
0.2469571,
-0.01151159,
0.01366... |
Ventricular septal defect following myocardial infarction. | Review of the literature since 1970 revealed more than 200 patients who had a ventricular septal defect following myocardial infarction and underwnet operation. Pathogenesis and diagnosis are discussed. The primary therapy is operative repair, which is considered from the standpoint of approach, timing, technique, conc... | 378,155 | [
-0.3075942,
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0.232436,
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0.2809527,
0.09777463,
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0.6372905,
0.1392053,
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0.4055165,
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0.04290834,
0.5691091,
0.1873361,
-0.210993,
-... |
Ia-Type alloantigens and humoral autoimmune responsiveness in insulin-dependent diabetes mellitus. | In the search for markers either closely linked to or identical with the hypothetical "diabetogenic major histocompatibility gene," immune region-associated alloantigens were defined in 80 patients with insulin-dependent diabetes and in 107 controls. A close association between the Ia-type alloantigen DRw3 and DRw4 and... | 378,240 | [
0.2033954,
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0.1272411,
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0.3075235,
0.2584468,
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0.1159626,
0.2715389,
-0.02236236,
-0.1077506,... |
The role of glucagon in the regulation of plasma lipids. | The role of glucagon in regulating plasma lipid concentrations (nonesterified fatty acids, ketone bodies, and triglycerides) is reviewed. The effects of glucagon-induced insulin secretion upon this lipid regulation are discussed that may resolve conflicting reports in the literature are resolved. In addition, the unres... | 378,241 | [
-0.02646087,
0.06553935,
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0.2854092,
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0.01712815,
0.1670747,
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0.1447351,
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0.08006302,
0.01192488,
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0.179684,
0.04041742,
0.1131644,
0.04481791,
-0... |
Epoxide hydrase in Trypanosoma cruzi epimastigotes. | 1. Microsomal fractions from Trypanosoma cruzi epimastigotes catalyze the hydration of styrene oxide to styrene glycol. The activity is linear up to 45 min of incubation, is proportional to microsomal protein concentration within certain range, and has an optimum pH of 8.5. 2. Double-reciprocal plots indicate a Km valu... | 378,266 | [
-0.3008152,
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-0.07729285,
0.1415416,
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0.1315949,
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0.461255,
0.2851357,
0.1398473,
-0.2814958,
... |
Stress analysis of single-tooth implants. II. Effect of implant root-length variation and pseudo-periodontal ligament incorporation. | This study delineates the effects of varying the root length as well as incorporating a soft pseudo periodonal ligament on the overall stress distribution for each of five different implant materials and one implant design. | 378,281 | [
0.1456748,
-0.01860516,
-0.1924752,
0.3238732,
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0.08289812,
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0.1347549,
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0.3520361,
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0.1529812,
0.06900432,
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0.139... |
Stress analysis of single-tooth implants. I. Effect of elastic parameters and geometry of implant. | Five different implant materials and three different geometries of ankylosed single-tooth implants were investigated. The stress distributions within and around the implants were determined by finite element analysis. Results show that the optimal combination of implant material and geometry can reduce implant and alve... | 378,283 | [
0.00410662,
0.2689339,
0.00181924,
0.4057083,
0.2268779,
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0.11355,
0.3415591,
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0.1368671,
0... |
Corneal endothelial cell function after storage in MK medium and hydrocortisone. | We stored rabbit corneas either in MK medium or MK medium plus hydrocortisone 10(-6)M for 7 days. The corneas stored in MK medium with hydrocortisone had better temperature reversal characteristics than those stored in MK medium alone. | 378,331 | [
-0.2439812,
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0.3625059,
0.2070066,
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0.223527,
-... |
Immunological aspects of superior limbic keratoconjunctivitis. | Three patients with superior limbic keratoconjunctivitis (SLK) were treated by conjunctival resection. The results of immunological studies and histological examination of the excised tissue were unremarkable; none of seven criteria of antibody dependence were met. We found no specific immune defects in three patients ... | 378,334 | [
0.2423343,
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0.2468368,
0.1685692,
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0.1468956,
0.09033166,
0.337538,
0.1027373,
0.2894875,
0.1543133,
-0... |
Chromosomes and causation of human cancer and leukemia. XXXII. Unusual features of Ph1-positive acute myeloblastic leukemia (AML), including a review of the literature. | Five cases of Ph1-positive AML were studied. In all cases a Ph1-chromosome was shown with banding techniques to be due to a translocation between chromosomes No. 9 and No. 22. Cases 1 and 4 were found to have more than one Ph1 with evidence of only on Ph1-translocation accompanying other chromosome abnormalities. Two c... | 378,356 | [
-0.4361793,
0.1931164,
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0.01453298,
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0.02098412,
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0.1257473,
0.1607744,
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0.3231637,
0.1534312,
-0.081499,
0... |
Childhood lymphoma in southern Iran. | A study of 81 childhood lymphomas diagnosed in the Department of Pathology of Pahlavi University Medical Center, Shiraz, Iran, encompassing all histologically diagnosed childhood lymphomas from the Fars Province, Southern Iran over a 14-year period (1963--1976) revealed a 3:1 male predominance and a 1:4 frequency compa... | 378,362 | [
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0.2813318,
0.145382,
-0.2186801,
0... |
Metastasizing extradural ependymoma of the sacrococcygeal region: case report and review of literature. | A case is discussed in which the patient presented with a primary extradural sacrococcygeal ependymoma and synchronous pulmonary metastasis. The clinical course has been characterized by recurrent pulmonary metastases. Management has consisted of repeated surgical resections of the pulmonary metastases and the tumor at... | 378,364 | [
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0.006244365,
0.2495645,
0.5665862,
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0.005390054,
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-0.3901388,
0.04816119,
-0.1756922,
0.1152874,
-0.04149845,
0.06279444,
0.0974... |
A nucleolar antigen found in a broad range of human malignant tumor specimens. | With rabbit antibodies to nuclear 0.01 M Tris-HCl, pH 8, extract or "nucleolar preparations" of human HeLa S3 cells and fluorescein-labeled goat anti-rabbit antibodies, bright nucleolar immunofluorescence was observed in 61 or 63 human adenocarcinomas, squamous cell carcinomas, sarcomas, hematological neoplasms, and ot... | 378,367 | [
-0.04093977,
-0.315691,
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0.1036624,
0.008109263,
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0.1546216,
0.3093453,
0.1113052,
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-0.09352888,
0.3241538,
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-0.06688133,
0.04223213,
0.3083887,
0.3790682,
0.05946514,
-0.1979389,... |
A secondary attachment site for bacteriophage lambda in trpC of E. coli. | We have determined the nucleotide sequence of a secondary lambda attachment site in trpC. Direct sequence analysis of lambdatrp transducing phage DNA fragments carrying the two prophage attachment sites reveals a 6 nucleotide homology in the crossover region which is a subset of the 15 nucleotide core sequence in the p... | 378,390 | [
0.1937363,
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-0.477025,
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0.07465115,
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0.2361718,
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0.1240074,
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0.07268555,
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0.02445205,
0.006861479,
-0.05440523,
0.06712656,
0.3305356,
-0.2715... |
Isolation of galactose-inducible DNA sequences from Saccharomyces cerevisiae by differential plaque filter hybridization. | Multiple nitrocellulose DNA filter replicas of plaques of in vitro generated recombinants of phage lambda and Saccharomyces cerevisiae have been screened by hybridization with 32P-labeled cDNA probes. These probes were representative of total poly(A)-containing RNA of yeast cells grown on acetate, galactose, glucose or... | 378,392 | [
0.02109455,
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0.3758149,
-0.2107196,
0.4403736,
0.2416236,
-0.2516277,
... |
Identification of initiation sites for the in vitro transcription of rRNA operons rrnE and rrnA in E. coli. | The transcription initiation sites of E. coli rRNA operons were determined using various DNA fragments derived from transducing phage lambda metA20 carrying rrnE and from hybrid plasmid pLC19-3 carrying rrnA. In vitro transcription products were analyzed for their 5' end sequences and their oligonucleotide compositions... | 378,406 | [
-0.3127609,
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-0.02821983,
0.3078706,
0.8635751,
0.187714,
-0.097401... |
In vitro processing of B. mori transfer RNA precursor molecules. | Ribonuclease P and 3'-5' nuclease, two enzymatic activities necessary for tRNA synthesis in E. coli, are also found in the silkgland cells of Bombyx mori. B. mori subcellular extracts containing RNAase P activity can cleave the E. coli tRNA precursor molecule endonucleolytically at the same site as the E. coli enzyme, ... | 378,409 | [
-0.1308868,
0.2068017,
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0.07733992,
0.3481676,
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0.4223292,
0.03105182,
-0.06455785,
0.1825547,
-0.1341207,
0.3626287,
0.3271312,
-0.048945... |
Pulmonary vascular response to endotoxin in normal and lymphocyte depleted sheep. | The cardiopulmonary effects of intravenously administered Escherichia coli endotoxin were studied in unanesthetized sheep. One group of animals was depleted of circulating T-lymphocytes while a non-depleted group served as control. T-lymphocyte depletion was accomplished by chronic thoracic duct drainage of lymph, remo... | 378,454 | [
0.06792856,
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-0.03799498,
0.1464746,
0.1110746,
-0.07506997,
0.0... |
Microvascular plasma velocity and indicator dispersion with hemorrhage. | The effects of stepwise hemorrhages on plasma flow velocity and indicator (FITC-Dextran) dispersion in series and parallel coupled microvascular vessels has been studied. The mesentery of cats (0.6 kg) anesthetized with Dial-Urethane was exposed and studied with a microscope equipped for fluorescense microscopy. Indica... | 378,455 | [
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0.1967123,
0.07292854,
... |
Analysis for diazepam and nordiazepam by electron-capture gas chromatography and by liquid chromatography. | We describe the use of electron-capture gas chromatography or reversed-phase "high-performance" liquid chromatography for concurrent analysis for diazepam and nordiazepam in serum. In the gas-chromatographic analysis our use of a new chemically deactivated stationary liquid phase, SP 2250-DB (Supelco, Inc.), resulted i... | 378,460 | [
-0.1474411,
0.07587305,
0.1099499,
-0.6462142,
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0.1389045,
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0.3023849,
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0.5706163,
0.2495541,
0.08732022,
0.003626624,
0.1091405,
-0.2631029... |
Determination of 3,4-dihydroxyphenylethyleneglycol in urine by gas chromatography with a flame ionization detector: a new rapid method. | 3,4-Dihydroxyphenylethyleneglycol, a major metabolite of noradrenaline in rat brain, is estimated alone or with 4-hydroxy-3-methoxyphenylethyleneglycol in rat and human urine by gas chromatography with a flame ionization detector. The samples are hydrolyzed and extracted at pH 2 with ethyl acetate. Then, to analyze onl... | 378,468 | [
-0.1748401,
0.2539978,
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0.1449168,
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0.417132,
0.2876566,
0.2127576,
0.1668001,
0.100794,
-0.04855278,
-0.16... |
The pituitary-gonadal response to the gonadotrophin releasing hormone analogue D-Ser (TBU)6-Des Gly10-LHRH-ethylamide in normal men. | We have studied the dose-response characteristics of the LHRH analogue D-Ser (TBU)6-Des Gly10-LHRH-ethylamide administered subcutaneously to five normal male volunteers. The relative potency of the analogue is about sixty times (FSH) and forty times (LH) that of the parent peptide and the increased potency and duration... | 378,469 | [
0.01041884,
0.04842662,
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0.07701677,
0.3300653,
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0.04579812,
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0.1874063,
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0.1095086,
0.1828423,
0.1965073,
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0.3181578,
0.01836094,
0.4302329,
0.1507227,
0.1301061,
0.1059016,
-0... |
Late hypertension following renal allotransplantation. | Post-transplant hypertension has been observed in 98 renal allograft recipients who had good renal function and whose follow-up was more than 15 months. The role of the original diseased kidneys as well as the role of the renal pressor system was studied with emphasis on late hypertension. Post-transplant hypertension ... | 378,492 | [
0.2100748,
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0.3679937,
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0.04560864,
0.2383835,
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0.1964265,
0.3046376,
0.2522479,
0.1848275,
0.1802883,
0.2959618,
-0.183814,
0.... |
The role of plasmapheresis in renal transplantation. | Plasmapheresis has been studied in ten patients who received cadaveric renal allografts. In six patients (group A), plasma was carried out on the first post-operative day and then on alternate days until six treatments had been completed. No beneficial effect was observed but treatment was well tolerated and there were... | 378,494 | [
-0.0900927,
0.2362964,
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0.0408847,
0.111417,
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0.04388155,
0.1899969,
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0.2464566,
-0.006198404,
0.01900751,
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0.2529653,
0.5945591,
0.06292397,
... |
Acute dislocation of the patella in children. The natural history. | On the basis of a survey of 55 cases, we can predict that one child in 6 with acute dislocation of the patella will develop recurrent dislocation. Two in 6 children have minor symptoms and the remainder are asymptomatic. The majority of patients show the radiological signs of patellofemoral dysplasia. | 378,498 | [
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0.1136108,
0.01292066,
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0.1630206,
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0.1215843,
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0.4407751,
0.2490146,
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0.4467426,
0.07998177,
-0.03027992,
0.3662812,
-0.02553716,
-0.211103,
... |
Clinical pharmacokinetics of propranolol. | Propranolol is completely absorbed after oral administration and widely distributed throughout tissues. Elimination occurs almost wholly by metabolic transformation in the liver and excretion of the resultant products in the urine. An active metabolite, 4-hydroxypropranolol and possibly other active compounds have been... | 378,502 | [
-0.3089541,
-0.19828,
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0.0316779,
0.0837942,
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0.0197192,
0.2456701,
0.08301258,
0.2605258,
0.1486404,
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0.1209401,
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0.06093726,
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0.3920659,
-0.02709291,
0.5882093,
-0.1142414,
-0.0... |
2,3-Diphosphoglycerate: its role in health and disease. | 2,3-Diphosphoglycerate (2,3-DPG) was first discovered and isolated in 1925. However, it was not until 1967 that the function of 2,3-DPG was explained. This resulted in multiple research projects devoted to elucidating the mechanism by which 2,3-DPG exerts it effect on the oxygen affinity of hemoglobin. In addition, a v... | 378,537 | [
-0.258643,
-0.4263971,
-0.1835217,
-0.233481,
-0.04754541,
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0.09644438,
-0.001934796,
-0.2244903,
0.02544493,
0.07238881,
-0.2416017,
-0.377968,
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-0.1070766,
0.003836666,
-0.07622772,
0.2489098,
0.2257289,
0.3124918,
-0.32867... |
Glipizide ('Glibenese') in maturity-onset diabetes mellitus. | A clinical evaluation was carried out in 19 maturity-onset diabetics to assess the effectiveness of glipizide in the treatment of newly diagnosed patients (11) not responding to diet alone and of patients (8) who had been inadequately controlled on other oral antidiabetic agents. Patients were studied over a period of ... | 378,559 | [
-0.2042141,
-0.01879248,
-0.3685488,
-0.1590546,
0.06788145,
-0.3103839,
-0.1247172,
-0.04958652,
-0.04878261,
-0.02796468,
0.1817002,
0.4218607,
-0.1611818,
-0.07282073,
-0.2208664,
-0.228911,
-0.3261328,
0.1968012,
-0.07245125,
0.2605816,
0.2729715,
0.4170774,
0.0319860... |
Thrombocytosis in chronic eosinophilic pneumonia. | Thrombocytosis has not yet been described in chronic eosinophilic pneumonia. A typical patient with chronic eosinophilic pneumonia is described. The patient's thrombocyte count was up to 900,000 per cu mm, which returned to normal under steroid therapy. Thrombocytosis may be associated with chronic inflammation and sho... | 378,571 | [
-0.06105153,
0.1025292,
0.06164396,
-0.25374,
-0.1673457,
0.08934524,
-0.05806889,
-0.01142585,
-0.2361369,
-0.01354255,
0.119368,
0.365416,
-0.134708,
-0.02634941,
-0.2661643,
-0.08003147,
0.1303191,
0.1939686,
0.06702352,
0.1873866,
-0.03652499,
-0.05051377,
0.01858399,... |
[Effect of high-dosage prednisolone administration on interstitial transplantation edema following allogeneic kidney transplantation in rats]. | To measure subcapsular pressure of rat kidneys and kidney allografts, microcatheters were implanted in the subcapsular space and the pressure was continuously recorded with a transducer. Subcapsular pressure was found to increase significantly during allograft rejection. After single bolus injection of prednisolone 300... | 378,591 | [
0.1247426,
-0.04155679,
-0.01260554,
-0.171857,
0.1574655,
-0.2928842,
-0.1154703,
0.1974424,
-0.1662882,
-0.1142916,
0.2764128,
-0.2371289,
-0.07335032,
0.02199147,
-0.4718866,
-0.2835896,
0.08514586,
0.09716164,
0.2890163,
0.29618,
0.3767025,
0.0447012,
0.1202162,
0.0... |
[Active enhancement using B-lymphocytes]. | B-lymphocytes given 7 days prior to auxiliary heterotopic heart transplantation significantly delay transplant rejection. T-lymphocytes or purified erythrocytes have no effect at all on the subsequent heart graft. The beneficial effect of blood transfusions could be due to the transfusion of B-lymphocytes, which create... | 378,596 | [
-0.2276811,
-0.06628148,
-0.5578398,
-0.0285094,
0.05238541,
-0.2930095,
-0.1207057,
0.1838623,
-0.2146124,
0.1221038,
-0.1736176,
0.492762,
0.2882522,
0.1532532,
-0.3877549,
-0.2149859,
-0.4798202,
-0.1818422,
0.1021463,
0.3982159,
0.3988641,
0.3686375,
-0.02122322,
-0... |
[Inhibition of stimulated gastric secretion with simultaneous administration of cimetidine and somatostatin]. | In four gastric fistula dogs we studied the effect of cimetidine (5 mg/kg/h) and somatostatin (10 microgram/kg/h), alone or in combination, on gastric secretion stimulated by histamine (160 microgram/kg/h) or pentagastrin (6 microgram/kg/h). Acid and pepsin output after histamine stimulation was more reduced by cimetid... | 378,600 | [
-0.1300488,
-0.2924927,
-0.1108746,
-0.1928042,
0.2521613,
-0.09418806,
0.1334052,
-0.4028373,
0.01553249,
0.120704,
0.00819183,
0.02142006,
-0.2258881,
-0.416367,
-0.5350893,
-0.2166239,
-0.2882582,
0.09796285,
0.06536883,
0.2875607,
0.2444559,
-0.2322507,
-0.03852103,
... |
[Comparative studies on the incorporation of autologous and homologous spongiosa in the compact layer of long bones]. | The healing of fresh autologous and homologous cancellous bone graft in gaps made in diaphysis was checked in a comparative test series of dogs. The general revascularization comes from the medulla. During the 2nd week the newly formed vessels in the homograft are obliterated. These are rebuilt during the 3rd week. At ... | 378,603 | [
0.04125595,
0.1893291,
0.07425244,
-0.05171265,
-0.006228788,
-0.5332569,
-0.02239731,
-0.1818093,
0.01200641,
-0.1039521,
0.03133208,
-0.1949974,
-0.05728013,
-0.1278301,
-1.06979,
-0.1939007,
-0.09408715,
-0.03278349,
-0.03013864,
-0.02946096,
0.1882691,
0.04958476,
-0.... |
Differences in intrahepatic portal-systemic shunting in alcoholic and nonalcoholic liver disease as assessed by liver scan, portal pressure, and E. coli antibodies. | The interrelationship among portal vein pressure, 99mTc sulfur colloid liver/spleen scan abnormality, and serum E. coli antibody titers has been examined in 33 patients with alcoholic liver disease (ALD) and compared with 24 patients with liver disease not related to alcohol (non-ALD). A correlation between portal vein... | 378,627 | [
-0.07430813,
0.06352113,
-0.08221406,
0.09202657,
-0.1126518,
0.01084089,
-0.296189,
-0.278477,
-0.08430224,
0.1278236,
0.2614836,
-0.338143,
-0.2818186,
0.5211341,
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0.1795119,
0.03868821,
0.2758173,
-0.1178587,
-0.03812296,
-0.09651383... |
[Lidocaine prophylaxis in the pre-hospital phase of acute myocardial infarction (author's transl)]. | In a double blind study performed in cooperation with 69 emergency doctors and general practitioners in the catchment areas of the university and of the city hospital in Lübeck the action of intramuscular lidocaine on mortality and on the incidence of arrhythmias was investigated in patients with acute myocardial infar... | 378,632 | [
-0.05029769,
0.1040561,
-0.416252,
-0.05377054,
0.1516538,
-0.1774355,
-0.1088735,
-0.2520232,
-0.4978803,
-0.133771,
0.03402213,
0.4563482,
0.2354699,
0.028561,
-0.01580553,
-0.2016514,
-0.1309452,
0.08461346,
-0.1642696,
0.3164692,
0.2841062,
0.2346445,
-0.05823403,
0... |
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