title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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The immunosuppressive effects of 5-fluorocytosine and 5-fluorouracil. | 5-Fluorocytosine (5-FC) is weakly immunosuppressive when given in lethal doses to mice, and inhibits the responses of mouse and human lymphoid cells to plant lectins at concentrations of 1 mg/ml or more. 5-FC has about 1% of the immunosuppressive activity of 5-fluorouracil in vivo and 0.1% in vitro. Deamination of smal... | 421,598 | [
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[Clinical testing of an image memory in peroperative roentgen diagnosis]. | The relatively high radiation exposure when applying mobile X-ray image intensifiers to surgical radiology can be distinctly reduced by the ultilzation of an electronic image memory, which makes visible as long as you like the last fluoroscopic image of a fluoroscopic scene on the viewing monitor without switching on t... | 421,630 | [
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[Bypass enteritis. The significance of end-to-end and end-to-side anastomosis in jejunoileostomy]. | Jejunoileostomy is an effective procedure in the treatment of morbid obesity. The end-to-end and end-to-side anastomoses are competitive techniques. The end-to-end anastomosis prevents a reflux of food into the shunted intestine loops, but stool reflux to the colon very often occurs over the drainage anastomosis. The p... | 421,637 | [
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Sigmoidal ulcer as a cause of acute colonic obstruction. | A case of primary nonspecific ulceration of the sigmoid colon initially manifesting as acute colonic obstruction is presented. Other possible etiologies of acute sigmoidal obstruction are discussed. | 421,646 | [
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Eosinophilic gastroenteritis involving the ileocecal area. | Eosinophilic gastroenteritis, an idiopathic inflammation of the alimentary canal, is characterized by infiltration of the intestinal wall by eosinophils, massive submucosal edema, and peripheral eosinophilia. It is generally confined to the gastric antrum and proximal small intestine. A young woman had an eosinophilic ... | 421,648 | [
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The role of the reactive disulfide bond in the interaction of cholera-toxin functional regions. | The chemical reactivity of disulfide bonds towards reducing agents, in the absence of denaturing conditions, in cholera toxin has been studied. Treatment of the toxin with dithiothreitol or other mercaptans gave selective reduction of one of the six disulfide bonds of the protein. This reactive disulfide links two dist... | 421,689 | [
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Muscle abnormalities in coeliac disease: studies on gross motor development and muscle fibre composition, size and metabolic substrates. | In 11 children with coeliac disease gross motor development was assessed before and during diet treatment using the gross motor subscale of the Denver developmental screening test. ATP, creatine phosphate (CP), glycogen and lactate concentrations, muscle fibre size and fibre composition were measured in specimens obtai... | 421,695 | [
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Effect of flavoxate on hyperactive detrusor muscle. | The effect of Flavoxate on hyperactive detrusor contraction was studied in 37 patients, including 11 patients in whom the drug was administered intravenously during the urodynamic study. Beside the evaluation of frequency, nocturia and enuresis, the amplitude and the onset of uninhibited detrusor contraction (in correl... | 421,699 | [
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[Vagal thermoreceptors in the gastro-intestinal area. Their role in the regulation of the digestive motility (author's transl)]. | In anaesthetized cats, sensory vagal units were recorded in the nodose ganglion by means of extracellular glass microelectrodes. In the antrum and the duodenum we have found receptors tonically activated by warm (38-51 degrees C with an optimum at 46-49 degrees C) or cold (36-10 degrees C with an optimum at 12-10 degre... | 421,757 | [
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Anatomical and electrophysiological identification of motoneurones supplying the cat retractor bulbi muscle. | Motoneurones innervating the retractor bulbi muscle in the cat have been identified by retrograde labelling with horseradish peroxidase, by intracellular recording and by intracellular staining with horseradish peroxidase. Their somata are found in an accessory abducens nucleus, analogous to that described in some othe... | 421,760 | [
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Do Schwann cells produce collagen type III? | The fact that collagen from both normal nerve endoneurium and Schwann cell tumours present characteristics of collagen type III, suggests that Schwann cells produce this type of collagen. | 421,776 | [
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The influence of homologous plasma and fetal calf serum on human lymphocytic cortisol metabolism. | The influence of a) tissue culture medium (RPMI), b) homologous plasma (HP), and c) fetal calf serum (FCS) on lymphocytic cortisol metabolism was compared to that of phosphate buffered saline alone. RPMI was found to enhance the conversion rate 1.71 times, whereas HP and FCS enhanced it about 3.2 times. Raising the tem... | 421,777 | [
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Influences of temperature change on the relaxation and amplitude inhibition by noradrenaline in the rabbit jejunum. | In the rabbit jejunum, the elevation of temperature within the range of 25-37 degrees C diminished the sensitivity to noradrenaline (NA) for both the relaxation and amplitude inhibition. The relaxation by NA was mainly mediated via adrenergic beta-receptors at 25, 30 or 37 degrees C. The amplitude inhibition was mediat... | 421,805 | [
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Permeability of Ehrlich ascites cells and spectrophotometric assay of the sub-cellular enzymes. | A permeabilization method which allows the assay of intracellular enzymes of the Ehrlich ascites cells is described. The developmental changes in the activity of lactic dehydrogenase and glucose-6-phosphate dehydrogenase of toluene-treated Ehrlich ascites cells were studied. | 421,812 | [
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GABA stimulates the rabbit corneal endothelial fluid pump. | GABA and its analogues were shown to activate the rabbit corneal endothelial fluid pump in the micromolar range. The stimulation was abolished by bicuculline and chlorpromazine, but not by picrotoxin. | 421,825 | [
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Binding of Lens culinaris lectin to sea urchin embryo chromatin. | Lentin binds specifically to sea urchin embryo chromatin. This binding is saturable and inhibited by alpha-methyl-mannose. Scatchard plot analysis of the binding reaction suggests a single binding site. | 421,828 | [
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A rat model of neurobehavioral development. | The neurobehavioral evolution of the normally growing rat has been investigated by means of a series of reflex, motor and sensory tests from birth up to weaning. A sequential development of behavioral responses has been assessed over this 21-days period, and 2nd week following birth representing an important step in th... | 421,830 | [
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A simple interspike interval analyzer for study of neuronal spike trains. | A simple, low cost interspike interval analyzer for the analysis of trains of nerve impulses is described. The analyzer is built with readily available integrated circuits and has been used to analyze spike trains in the lateral vestibular nucleus of cats. | 421,835 | [
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Penetration barrier to sodium fluorescein and fluorescein-labelled dextrans of various molecular sizes in brain capillaries. | The permeability of the blood-brain barrier to sodium fluorescein, or fluorescein-labelled dextrans of various molecular weights, was investigated. Unlike the capillaries in both the area postrema and the eminentia mediana, the capillaries of the cerebral cortex were impermeable to all the intravenous tracer substances... | 421,851 | [
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Thyroid activity in response to some gonadal steroids in methallibure-treated Heteropneustes fossilis (Bloch). | Methallibure treatment is as effective as hypophysectomy in reducing thyroid activity in H. fossilis. Sex steroids (TP and EB) administration restored thyroid activity in methallibure-treated females to normal level, but failed to elicit any response in males. This drug seems to block TSH secretion and thyroid hormone ... | 421,857 | [
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[Case report on a myocardial ischemia due to medical tocolysis with ritodrin (pre-par) (author's transl)]. | In the 24 year old former competitive athelete tocolysis with ritodrin (pre-par) was started at 28 weeks gestation in her second pregnancy for premature labor. Diffuse cardiac ischemia occurred during the intravenous infusion of ritodrin. The betamimetic drug was the factor which started the myocardial ischemia as evid... | 422,024 | [
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[Primary splenic cysts. Clinical study of a rare from of splenomegaly]. | Two cases of a dysontogenetic splenic pseudocysts with seldom symptomatology are described. A splenomegaly can easily be cleared up by angiography of the truncus coeliacus. The risk of operation is minor to that in other forms of splenomegaly. Prognosis is good. | 422,081 | [
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A surfeit of surveys: escalating data demands on community mental health centers. | In a recent six-month period, a state-operated community mental health center was required to gather data for nine major surveys, reviews, and budget requests. Such surveys cover much the same ground, yet without any attempt to standardize formats so that the data a center compiles for one survey can be used in the nex... | 422,131 | [
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Center provides emergency care without unneeded inpatient units. | When a study showed that a hospital had enough beds for its service area but that one growing segment of this area needed faster access to emergency care, the Ambulatory Care Center/Emergency Services System (ACCESS) was established. Through its program and facility, ACCESS provides immediate ambulatory and emergency c... | 422,144 | [
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Affirmative action: what's really fair? | The concept of affirmative action has been the subject of much controversy in the past. Opponents of the concept believe that it provides preferential treatment for minorities and females based upon factors of race and sex that are both unconstitutional and illegal. Proponents believe the concept is needed to make up f... | 422,158 | [
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Partial trisomy 14q. | A dysmorphic female born with partial trisomy of the proximal segment of the long arm of chromosome 14 had 47 chromosomes. The extra one was acrocentric, smaller than the D group, and bigger than the G-chromosome group. By GTG banding it was identified as a deleted chromosome 14, the karyotype being 47,XX,+del 14(q24).... | 422,208 | [
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Histocompatibility-linked genetic control of susceptibility to age-dependent polioencephalomyelitis in mice. | Susceptibility to induction of immune polioencephalomyelitis (IPE) was found to be controlled by a gene that is closely linked to the H-2 complex. Whereas mice of the AKR (H-2k) strain were susceptible to IPE induction, H-2-congenic mice, AKR.H-2b (H-2b from C57BL/6) and AKR.M (H-2m), were resistant. However, susceptib... | 422,235 | [
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Common antigens among systemic disease fungi analyzed by two-dimensional immunoelectrophoresis. | The interpretation of immunological results in systemic mycoses has been complicated by cross-reactions among specimens from patients with blastomycosis, coccidioidomycosis, and histoplasmosis. The fungal preparations used in these tests evidently contained one or more antigens in common. Two-dimensional immunoelectrop... | 422,249 | [
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-0.1539094... |
The nitroblue-tetrazolium test in granulocytes of the cerebrospinal fluid--methodological problems. | It was originally our intention to study the suitability of the nitroblue-tetrazolium (NBT) test for differentiating the causes of granulocytic pleocytosis of the cerebrospinal fluid (CSF). However, several methodological problems were encountered and required extensive preliminary studies. The test was initially perfo... | 422,251 | [
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... |
A solid-phase radioimmunoassay to detect anti-tuberculin antibodies in the guinea pig. | Despite the importance of the guinea pig as a model test animal for studying the humoral immune response in comparison to the development of cellular immunity after BCG or tuberculosis infection, no precise and sensitive method for the determination of such antibodies is available. We developed an indirect solid-phase ... | 422,282 | [
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Nummular eczema of statis origin. The backbone of a morphologic pattern of diverse etiology. | A total of 113 patients with nummular eruptions of unknown origin were collected over a period of 8 years. This number was reduced to 82 patients by exclusion of known clinical entities which became unmasked during the study. All 82 patients were found to have varicose veins and/or edema of the lower extremities. Autoe... | 422,311 | [
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[21-arginine-A] insulin: a biologically active analog. | An analog of sheep insulin which differs from the parent molecule in that the C-terminal amino acid residue of the A chain, asparagine, is replaced by arginine, has been synthesized and isolated in highly purified form. The [Arg21] A chain of sheep insulin was synthesized by the fragment condensation approach and isola... | 422,323 | [
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Solid-phase active site inhibitors of proteinases. | Phenylalanine chloromethyl ketone covalently attached to porous glass beads was synthesized to serve as a solid-phase active site directed inhibitor of chymotrypsin-like proteolytic enzymes. The solid-phase reagent inhibited 20 nmol of bovine chymotrypsin per gram of glass and covalently bound 30 nmol of protein per gr... | 422,326 | [
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Synthesis, characterization and fluorescence studies on N-alpha-dansylalanyllysyl trypsino (HIS-46)-methane. | The 1-dimethylamino-5-naphthalene sulfonyl (dansyl) derivative of alanyllsyl chloromethane was synthesized and employed to introduce the fluorescent dansyl moiety specifically into the active site of trypsin via affinity labelling. The potential of dansylalanyllysyl chloromethane lies in its high degree of selectivity ... | 422,327 | [
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0.05910284,
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Method of measuring aqueous humor flow and corneal endothelial permeability using a fluorophotometry nomogram. | A new method of measuring aqueous humor flow and corneal endothelial permeability to fluorescein using a fluorophotometry nomogram is described. This method is compared to four other methods, two of which have been described previously. All five methods were carried out simultaneously in a group of 20 normal human subj... | 422,334 | [
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... |
Effect of intraocular irrigating solutions on intracellular membrane potentials and swelling rate of isolated human and rabbit cornea. | Isolated human and rabbit corneas were incubated in glutathione bicarbonate Ringer solution (GBR), balanced salt solution (BSS), or 0.9% NaCl solution. The swelling rate of human corneas was 25.5 micron/hr in GBR and significantly increased to 32.7 in BSS and 66.1 in NaCl. The epithelial intracellular potential of huma... | 422,335 | [
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0.38810... |
Torsion of the spleen in a five-and-a-half-month-old infant. | In this report, we describe torsion of the spleen in a five-and-a-half-month-old infant, thus far the youngest reported patient in the literature. Celiac angiography and tuftsin determination confirmed the clinical impression that the pathology was confined to the spleen. The infant underwent a splenectomy and made an ... | 422,342 | [
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... |
[Panniculitis nodularis febrilis non suppurative in metastasizing soft-tissue sarcoma]. | Report of a 28-year-old female patient with a metastasizing soft tissue sarcoma confined to the oral mucosa and subcutis. The basic disease attracted clinical attention as a nodular febrile nonsuppurative panniculitis (Pfeifer-Weber-Christian disease). Perivascular tumor cells in the subcutis obviously induced localize... | 422,355 | [
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0.03536409,
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... |
The controversial relationship between loudness discomfort levels and acoustic reflex thresholds. | Controversy presently exists concerning the relationship between loudness discomfort levels (LDL's) and acoustic reflex thresholds (ART's). In this study, LDL's and ART's were obtained for two groups of ten normal-hearing adult subjects and one group of ten adult subjects with bilateral sensorineural hearing losses. Th... | 422,423 | [
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... |
The influence of hearing aid nonlinear distortion on two auditory tasks. | A study is reported which examines the influence of hearing aid nonlinear distortion on multitone pitch perception. Normal-hearing subjects produced results indicating that hearing aid-generated harmonic and intermodulation components did significantly affect pitch judgments. Substantial differences in the amount of di... | 422,424 | [
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0.1394242,
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Influence of cardiac output on intrapulmonary shunt. | The effect of changing cardiac output on intrapulmonary shunt was studied in the setting of hemorrhagic pulmonary edema induced by intravenous oleic acid in 17 alpha-chloralose-anesthetized dogs. The dogs were mechanically ventilated and cardiac output was alternately depressed and augmented using either pharmacologic ... | 422,447 | [
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0... |
Calculation of ventilation needs for confined cattle. | Fundamental to maintaining a healthy environment in a mechanically ventilated livestock building is a continuous flow of air, with at least 4 exchanges per hour to remove moisture and aerosol contaminants. A correctly designed fresh air intake system is mandatory for uniform air distribution. Proper insulation is essen... | 422,460 | [
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0.4327563,
0.059178... |
Poor growth performance associated with hypocupremia in Hawaiian feedlot cattle. | Poor feedlot performance in native Hawaiian feedlot cattle was investigated. Cattle were first noticed to be affected 40 to 60 days after arrival at the feedlot, as judged by their retarded growth, when compared with penmates. Marked hypocupremia was detected in all 10 cattle examined, irrespective of time in the feedl... | 422,461 | [
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0.5804331,
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Effect of carbadox on growth, feed utilization, and development of nasal turbinate lesions in swine infected with Bordetella bronchiseptica. | Carbadox in combination with sulfamethazine did not interfere with the activity of sulfamethazine in clearing experimentally induced Bordetella bronchiseptica nasal infection. Evaluations in three field cases of infectious atrophic rhinitis indicated that carbadox in the feed was as effective as chlortetracycline + sul... | 422,462 | [
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0.3813693,
-0.181... |
Evidence for a haematogenous origin of some of the macrophages appearing in the spinal cord of the rat after dorsal rhizotomy. | A single dose of colloidal carbon was given intravascularly to young adult rats in order to label circulating monocytes. Two days after injection dorsal rhizotomies were performed on the fifth to eighth cervical nerves on the right side. The rats were killed 1, 3, 4 and 8 days later. Electron microscopic examination of... | 422,475 | [
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Spectrophotometric analysis of binary mixtures of sulfonamides. | Different methods for analyzing binary mixtures by using 2 wavelengths are reviewed. The absorbance ratio calculated at 2 wavelengths, not including the isoabsorptive point, was a quadratic function of relative concentration. The curve-fitting process using orthogonal polynomials was applied to obtain the quadratic equ... | 422,506 | [
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Comparison of the membrane composition of Spiroplasma citri and the corn stunt Spiroplasma. | Components of membranes isolated from Spiroplasma citri and corn stunt spiroplasma grown at 28 degrees C were analyzed. On a protein basis, lipid phosphorus was lower and cholesterol was higher in S. citri. Only minor differences between the two species were found in fatty acid composition, reduced nicotinamide adenine... | 422,510 | [
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Physician marriages. | A questionnaire study of physicians' ratings of various aspects of their marriage, was sent to 100 randomly selected physicians in Ramsey County (St. Paul, Minnesota). Eighty per cent of the sample responded. All 80 had been married at least once. There were fewer divorces reported compared with the general population.... | 422,522 | [
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Absorption, fluorescence, and linear dichroism spectra of fluorescein mercuric acetate (FMA) bound to F-actin. Two kinds of effects of divalent cations. | Two kinds of F-actin were prepared; one binds magnesium at the unique divalent cation binding site of actin protomer and the other binds calcium at this site. They were designated as F(Mg)-actin and F(Ca)-actin, respectively. The binding of fluorescein mercuric acetate (FMA) to F(Mg)-actin and F(Ca)-actin was studied s... | 422,536 | [
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Further studies on a human lung tumor-associated antigen. Comparison of antigens from different tumors. | A human lung tumor-associated antigen was purified to homogeneity from a crude cell-free extract of a human lung adenocarcinoma using standard biochemical procedures. In order to facilitate monitoring the recovery of antigen, trace amounts of previously purified and radioiodinated antigen from another lung tumor were a... | 422,569 | [
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0.05504866,
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Fractures at the base of the thumb: treatment with oblique traction. | Oblique traction on the thumb metacarpal, originally described for the treatment of Bennett's fracture, has been applied to comminuted intra-articular fractures of the thumb metacarpal to counter the forces that cause shortening and varus angulation. It also has been applied to fractures of the trapezium to restore con... | 422,612 | [
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0.09... |
The association between congenital elevation of the scapula and diastematomyelia: a preliminary report. | Of forty-six patients with congenital elevation of the scapula, diastematomyelia was confirmed in four and was probably present in five others. Possible reasons for the previously unsuspected association are presented. | 422,634 | [
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Decompression of the extensor tendons at the wrist in rheumatoid arthritis. | Simple decompression of the extensor tendons at the wrist was carried out on fifty-four wrists in a total of forty-one patients with rheumatoid disease. This procedure was combined with excision of the ulnar head in forty-five wrists. Complete resolution of the synovitis occurred in 81.5 per cent of the wrists. In two ... | 422,635 | [
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... |
The management of late diagnosed congenital dislocation and subluxation of the hip-with special reference to femoral shortening. | Thirty hips affected by congenital dislocation or subluxation underwent surgical treatment between the ages of five and fifteen years, and the results are presented. Reduction was aided by concurrent femoral shortening in seventeen. An aggressive approach in older children not only relieves the presenting symptoms in m... | 422,637 | [
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Frequency difference between nuclear and polysomal sequences of poly(A)-containing RNA from cultured AKR mouse embryo cells. | The involvement of post-transcriptional mechanisms in the determination of the frequency distribution of messenger RNA sequences has been studied in cloned mouse embryo cells in culture. Hybridization kinetic experiments between poly(A)-containing RNA and complementary DNA have been used to study the alterations in fre... | 422,658 | [
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Superoxide dismutase specific activities in cultured human diploid cells of various donor ages. | It has been postulated that superoxide dismutase (SOD) protects cells from free radical-induced damage. In these experiments SOD specific activity was measured as established human diploid cell lines from various donor ages progressed through their in vitro lifespan. Significant elevations in activity occurred during t... | 422,668 | [
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0.00248189,
... |
Dyskinetoplasty in two species of trypanosomatids. | Dyskinetoplastic cells from both Crithidia fasciculata and Trypanosoma equiperdum lack detectable kinetoplast DNA (kDNA) by conventional staining techniques. Two dyskinetoplastic strains of T. equiperdum, either acriflavine-induced or spontaneously occurring, show normal amounts of kDNA (p = 1.692 g/cm3) in analytical ... | 422,672 | [
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0.1715141,
0.2408741,
0.00829368,
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Ectopic human growth hormone in ovaries and breast cancer. | Immunoreactive human GH (hGH) has been found in 8 of 118 surgically removed ovaries, with concentrations ranging from 50-51,000 ng/g tissue. The highest concentration was in an ovarian metastasis from an adenocarcinoma of the breast; a skin metastasis from this same carcinoma had an hGH concentration of 350,000 ng/g. A... | 422,705 | [
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0.3738529,
0.3462452,
-0.0753988... |
The use of contingent reinforcement for improving the personal appearance and hygiene of chronic psychiatric inpatients. | Chronic psychiatric patients were Ss in a study designed to evaluate the effectiveness of contingent reinforcement to improve personal appearance and hygiene. Ss were divided into four groups matched on age and years of hospitalization. Group 1 was rated on personal appearance and received contingent material reinforce... | 422,716 | [
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0.09061964,
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An inventory for the identification of child abusers. | Conducted a literature review to identify personality traits that are characteristic of individuals who abuse and neglect children. On the basis of reported traits, a Child Abuse Potential Inventory that consisted of 334 items was constructed. The Inventory was administered to 19 abusing and 19 matched nonabusing paren... | 422,737 | [
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Electron microscopic studies of serially sectioned cat spinal alpha-motoneurons. II. A method for the description of architecture and synaptology of the cell body and proximal dendritic segments. | The paper presents a method for ultrastructural analysis and description of neuronal architecture and synaptology of cat spinal alpha-motoneurons from complete series of consecutive ultrathin sections through the cell body and proximal parts of the dendrites. The method implies that sections are selected for analysis o... | 422,760 | [
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Aging in the rat olfactory bulb: quantitative changes in mitral cell organelles and somato-dendritic synapses. | Quantitative measurements of the major organelles in the mitral cell perikaryon as well as numbers of mitral somato-dendritic synapses, have been made on electron micrographs from rats aged 3 to 30 months. The volume fraction of the cisternae of rough endoplasmic reticulum (RER) is constant throughout the period studie... | 422,764 | [
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Technical note. Recognition of head motion during cranial computed tomography. | A television monitoring technique was developed to analyze patient head motion during cranial computed tomography (CT). The graphs recorded with this system, craniokymograms, are compared with simultaneous CT images. Two other applications of this system are shown with examples of experimental data. | 422,785 | [
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Lissencephaly (agyria) on computed tomography. | Unusual computed tomographic findings were observed in two infants with similar clinical pictures including delay in developmental milestones, seizures, decerebrated posture, and microcephaly. Computed tomography revealed small brain with widened subarachnoid space, smooth surface of the brain, uniformly enlarged ventr... | 422,798 | [
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Multiple cystic encephalomalacia of infancy: computed tomographic findings in two cases with associated intracerebral calcification. | Two initially healthy infants developed acute encephalopathic illnesses characterized by stupor, seizures, cerebrospinal fluid (CSF) erythrocytic and monocytic pleocytosis, increased CSF protein, and decreased CSF glucose and progression to chronic decerebration. In one case, herpes simplex virus was recovered from cut... | 422,799 | [
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Sexual characteristics of preadolescent childrens' voices. | This investigation was undertaken to enlarge current understanding of the acoustic properties which influence the perception of maleness and femaleness in the voices of prepubertal children. Perceptual judgments of sexual identity were obtained in response to tape recordings of whispered and normally phonated vowels, n... | 422,813 | [
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Prevention of femoral vein occlusion by local injection of Thrombolysin in the rat. | An experimental model was developed that will produce femoral vein occlusion greater than 90% of the time in rats weighing less than 500 grams. This standard venous clot, produced by combining intimal trauma with local venous stasis, can simulate clinical crush and replantation problems. Using this standard clot model,... | 422,823 | [
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0.23... |
Ultraviolet radiation-induced inflammation and leukocytes. | To evaluate the role of leukocytes in inflammation induced by ultraviolet radiation, the response of guinea pigs make leukopenic with cyclophosphamide was compared with the response of nonleukopenic animals. The response of leukopenic animals to UVB (295 nm) was significantly altered. Leukopenic animals and saline-trea... | 422,868 | [
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... |
Superiority of 24-hour outpatient monitoring over multi-stage exercise testing for the evaluation of syncope. | Twenty-four hour outpatient monitoring was compared with maximum multi-stage Treadmill exercise testing for the detection of dysrhythmias producing syncope or near syncope in 119 patients. All patients had cardiovascular disorders; only 21% had coronary artery disease. Patients with obvious cause of syncope and/or sign... | 422,911 | [
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0.09451322... |
Effect of cadmium on salt hypertension in rats. | The suggestion that cadmium-induced hypertension in rats might be due to renal sodium retention, known to result from Cd treatment, was examined. Young female rats were given a regimen of intraperitoneal cadmium treatments reported to cause hypertension reliably within a month. They were sensitized to the development o... | 422,935 | [
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Safety evaluation of toothpaste containing chloroform. II. Long term studies in rats. | The results of a preliminary rangefinding 13-wk oral toxicity study and of two longer term studies on chloroform in toothpaste base are reported. Significant changes in serum enzymes and certain haemotological parameters were seen at the higher dose-levels in the rangefinding study. Intercurrent disease made it necessa... | 422,937 | [
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Pharmacokinetics of triclosan in rat after intravenous and intravaginal administration. | The pharmacokinetics of triclosan was studied in sexually mature virgin Wistar rats. 14C-triclosan was injected either via the femoral vein, (iv, 5 mg/kg in polyethylene glycol-400) or into the vaginal orifice (ivg, 5 mg/kg in corn oil). Radioactivity was determined by liquid scintillation spectrophotometry. After iv a... | 422,939 | [
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Regeneration of sutured human peripheral nerves: an electrophysiological study. | Electrophysiological and clinical assessment of recovery of function was undertaken on 34 median and 33 ulnar nerve which had been resutured after complete section three and a half months to 24 years previously. An evaluation of different methods of repair was attempted. Our results suggested that re-exploration of the... | 422,969 | [
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Prospective study of 100 lumbosacral discectomies. | A prospective study of 100 patients undergoing discectomy was carried out. The neurological findings were documented preoperatively and at 1 month and 1 year postoperatively. The clinical and radiological data were analyzed with respect to significant associations. There were no complications. At a minimum of 1 year po... | 422,980 | [
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Swan-neck deformity secondary to osteomyelitis of the posterior elements of the cervical spine. Case report. | A case of osteomyelitis is described, involving the posterior elements of the cervical vertebrae in a 7-year-old girl and resulting in swan-neck deformity. Treatment was initiated with antibiotics, and the patient was placed in halo traction. Eventually posterior cervical fusion was performed, which provided excellent ... | 422,993 | [
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Transient ischemic attacks due to increased platelet aggregation and adhesiveness. Ultrastructural and functional correlation. | The authors report 22 cases of transient ischemic attacks (TIA's) manifested by amaurosis fugax or hemiparesis or paresthesia of less than 24 hours' duration. None of the patients demonstrated 1) evidence of atherosclerotic cerebral vascular disease on angiography, 2) evidence of intracranial lesion on brain scan, 3) c... | 422,999 | [
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Effects of maternal isoxsuprine administration on preterm infants. | A retrospective study of all inborn infants at 26 to 35 weeks' gestational age delivered from August, 1976, through July, 1977, was undertaken to determine the effects on the neonate of maternal isoxsuprine therapy for premature labor. Mothers of 43 infants received ISX within 48 hours of delivery and mothers of 107 re... | 423,034 | [
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0.2132416,... |
Pharmacology and use of muscle relaxants in infants and children. | Succinylcholine is a short-acting depolarizing neuromuscular blocker used to facilitate intubation; pancuronium is a longer-acting, nondepolarizing agent commonly employed to control ventilation in pediatric patients. The neuromuscular block produced by both drugs may be modified by patient age, acid-base and electroly... | 423,041 | [
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0.1187828,
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Incidence and significance of gastroesophageal reflux following repair of esophageal atresia and tracheoesophageal fistula and the need for anti-reflux procedures. | Patients with esophageal atresia and/or tracheoesophageal fistula are known to have disordered esophageal motility, but the incidence of significant gastroesophageal reflux requiring anti-reflux surgery remains undocumented. We have studied a series of patients from 2 wk to 13 yr post-repair, utilizing manometric motil... | 423,064 | [
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Determination of guanfacine in biological fluids by electron-capture GLC. | A quantitative electron-capture GLC method with good sensitivity is described for the determination of guanfacine in human plasma and urine. By condensing its amidino group with hexafluoroacetylacetone, guanfacine is converted to a pyrimidino derivative with better GLC properties than the parent drug. This method allow... | 423,095 | [
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0.1313235,
0.06178847,
... |
Chemical constituents of Echites hirsuta (Apocynaceae). | A phytochemical investigation of an ethanolic extract of the whole plant of Echites hirsuta (Apocynaceae) resulted in the isolation and identification of the flavonoids naringenin, aromadendrin (dihydrokaempferol), and kaempferol; the coumarin fraxetin; the triterpene ursolic acid; and the sterol glycoside sitosteryl g... | 423,102 | [
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-0.2... |
Fluorescamine use in high-performance liquid chromatographic determination of aminocaproic acid in serum. | A sensitive and specific high-performance liquid chromatographic determination of aminocaproic acid in serum is described. omega-Aminocaprylic acid is used as an internal standard. To 10 microliter of serum, 10 microliter of the internal standard solution and 50 microliter of ethanol are added. After centrifugation, a ... | 423,103 | [
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6-substituted 1-methylquinolinium-2-dithioacetic acid zwitterions: antileukemia activity. | Condensation of the anhydro bases derived from 6-substituted 1-methylquinaldinium iodides with carbon disulfide provided the 2-dithioacetic acid zwitterions. Since 1.6-dimethylquinolinium-2-dithioacetic acid zwitterion previously showed appreciable activity against P-388 lymphocytic leukemia in mice, a series of analog... | 423,123 | [
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... |
Synthesis of 1-phenyl-2-(phenylcarbamoyl)pyrazolidines as potential anticonvulsant agents. | Twelve 1-phenyl-2-(phenylcarbamoyl)pyrazolidines were synthesized from 1-arylpyrazolidines and aryl isocyanates. These adducts showed little anticonvulsant activity in the maximal electroshock seizure and pentylenetetrazol seizure assays. | 423,135 | [
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-0.5524173,
0.3994839,
0.004223845,
0.1858371,
-0.07357098,
0.02516235,
-0.07782342... |
Substrate specificity of the lactate dehydrogenase isoenzyme C4 from human spermatozoa and a possible selective assay. | The activity of lactate dehydrogenase (EC 1.1.1.27) in normal human sperm lysates and in human heart and liver homogenates was determined by using a variety of 2-oxoacids as substrates. Sperm preparations were active with pyruvate, 2-oxobutanoate, 2-oxopentanoate and 2-oxohexanoate, while heart and liver extracts utili... | 423,147 | [
-0.09523291,
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0.7021012,
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... |
Symplasma formation and decidualization in the pseudopregnant rabbit after intraluminal instillation of tricaprylin. | A pure neutral triglyceride, tricaprylin, was injected (Day 0) into isolated segments of the uterus of rabbits in which pseudopregnancy had been induced by i.v. injection of hCG 6 days before. The animals were killed in groups of 3 on Days 1, 2, 3, 4 and 6. Saline, simple ligation of the uterus or uterine trauma were u... | 423,151 | [
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0.08598295,
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0.06967276,
0.00730... |
The estimation of sperm motility in semen, on a membrane slide, by measuring the area change frequency with an image analysing computer. | A simple slide is described in which the base is a permeable membrane so that a suspension of spermatozoa (or other cells) may be examined under controlled conditions with a microscope. An objective method of assessing the motility of spermatozoa in undiluted or diluted semen from a wide variety of species including ca... | 423,153 | [
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0.2352305,
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Phosphonate analogue of 2'-deoxy-5-fluorouridylic acid. | The phosphonate analogue (6) of 2'-deoxy-5-fluorouridylic acid has been prepared via a Pfitzner--Moffatt oxidation and Witting reaction. This compound was found to inhibit thymidylate synthetase from three sources and to be cytotoxic to H.Ep.-2 cells in culture. | 423,172 | [
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0.4424522,
0.3339259,
0.1743105,
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... |
Syntheses and antiinflammatory actions of 4,5,6,7-tetrahydroindazole-5-carboxylic acids. | A novel series of 1-aryl-4,5,6,7-tetrahydro-1H-indazole-5-carboxylic acids and 2-aryl-4,5,6,7-tetrahydro-2H-indazole-5-carboxylic acids were synthesized via condensation between a phenylhydrazine and a 2-(hydroxymethylene)cyclohexanone-4-carboxylate, and the antiinflammatory activity was determined. In the carrageenan ... | 423,183 | [
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0.1952928,
0.01250251,
-0... |
Structural requirements for progestational activity. Synthesis and properties of rac-8alpha,9beta,10alpha,14beta-progesterone. | rac-8alpha,9beta,10alpha,14beta-Progesterone, 1, has been synthesized and subjected to X-ray crystallographic analysis which established that the ring conformations are A, 1beta-sofa; B, chair; C, chair; and D, intermediate between an envelope and a half-chair. This compound is 10% as active as progesterone in the Clau... | 423,192 | [
0.1675297,
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0.5006574,
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... |
A study of faculty attitudes toward Ohio State's three-year medical program. | Three-year curricula, once a proliferating innovation in medical education, are now rapidly waning with the fading of capitation support and the easing of physician manpower shortages. In this article the authors examine faculty opinion of a three-year medical program at the Ohio State University. Using a Likert attitu... | 423,220 | [
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0.2235279,
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0.02694122,
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0.009970637,
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0.2464916,
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0.1472294,
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Aseptic necrosis of the hip in sickle cell disease. | Aseptic necrosis of the hip occurs in people with sickle cell disease. No one physician has had a great deal of experience treating this lesion. Because sickle cell patients are felt to have decreased longevity, traditional treatment is frequently not offered or considered. The purpose of this paper is to report the re... | 423,275 | [
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0.02547339,
0.2020698,
0.3401885,
0.1681731,
-0.028348... |
Thyroid gland disorders in African children. | Although endocrine disorders are uncommon in black African children, thyroid gland disorders made up 37 percent of all types of 27 endocrine disorders seen at University College Hospital, Ibadan, Nigeria over a five-year period. The age range of the children was four months to 14 years. Diagnoses largely depended on cl... | 423,287 | [
-0.1040105,
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0.3512833,
0.01205407,
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... |
Hand-foot roentgen findings in sickle cell anemia. | X-ray findings in the hands and feet of 420 sickle cell anemia patients were studied during the six-year period, 1972-1978. A correlation between roentgen findings and clinical presentations is emphasized. | 423,293 | [
0.01815681,
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0.1538377,
0.2449043,
0.05910637,
... |
Molecular forms of cholinesterases in cerebrospinal fluid, blood plasma, and brain tissue of the beagle dog. | In the present study we have investigated the activity of AChE and BuChE in the cisternal CSF of the Beagle dog and have outlined the characteristics of the molecular forms of both enzymes. The same enzymes were also investigated in samples from blood plasma and brain tissue. It is concluded that AChE in CSF originates... | 423,312 | [
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0.2268664,
0.06605162,
0.2798737,
0.07246021,
-... |
Intracellular studies of GABA and taurine action on the neurons of the cat sensorimotor cortex. | The action of taurine and GABA on the cat cerebral cortex neurons was studied. Electrophoretically administered taurine and GABA hyperpolarized the neuron membrane. GABA, in contrast to taurine, sharply increased the somatic membrane conductance. Taurine action was weaker than that of GABA and its effects were not alwa... | 423,315 | [
-0.003543672,
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0.301706,
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0.1849933,
0.1110858,
0.3311455,
0.1302186,
... |
The cystometric nuclear cystogram. | Vesicoureteral reflux is a common clinical problem that we monitor by interval nuclear cystography. Of the children having nuclear cystograms 40% also have voiding abnormalities, including incontinence (damp pants), urgency and infrequent micturition. We have evaluated these symptoms by recording the intravesical press... | 423,335 | [
0.05956496,
0.1696437,
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0.1213814,
0.07413962,
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0.5185058,
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-0.02925133,
0.21... |
[Toxicological studies on fosfomycin-Na salt. I. Acute toxicity in mice and rats (author's transl)]. | The acute toxicity of sodium fosfomycin (FOM-Na), a new antibiotic in ICR mice and Wistar rats has been investigated. The LD50 values in mice were: 1,230 (male), 1,225 (female) mg/kg by i.v.; 2,175 (m), 2,467 (f) mg/kg by i.p.; 2,625 (m), 2,662 (f) mg/kg by i.m.; 5,100 (m), 6,150 (f) mg/kg by s.c. and 8,020 (m), 7,300 ... | 423,368 | [
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0.09658175,
0.5364058,
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0.0404589,
-0.1652512,
... |
[Evolution of lesser circulation hypertension in patients with congenital heart defects based on the example of an interventricular septal defect]. | The results of direct pressure measurement in pulmonary circulation in 452 patients with ventricular septal defect (216 males and 236 females), whose age ranged from 12 months to 37 years, were analysed. The findings of diagnostic catheterization of the heart in 150 practically healthy persons 12 months to 40 years of ... | 423,432 | [
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0.07631305,
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0.2759373,
0.0006344353,
0.01627807,
-0.02026727,
0.04177361,
0.026349... |
[Characteristics of the pathogenesis of pulmonary hypertension and the formation of cor pulmonale in the basic forms of chronic nonspecific lung diseases]. | A group of 206 patients with the main forms of chronic nonspecific diseases of the lungs (chronic bronchitis, chronic pneumonia, and bronchiectasis--local and diffuse) was studied. The condition of pulmonary ventilation, bronchial patency, and hemodynamics of pulmonary circulation were analysed. Comparison of the data ... | 423,433 | [
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0.2219621,
0.302935,
0.1518025,
0.2363916,
0.0205774,
-0.08686256,
... |
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