title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Inhibition of adrenal function in man by heparin or heparinoid Ro 1-8307. | Heparin and the heparinoid Ro 1-8307 inhibited the secretory rate of aldosterone in physiological or pathological aldosteronism to the level found in normal subjects on liberal sodium intake. In addition, these compounds inhibited corticosterone biosynthesis, although less markedly than that of aldosterone. Indications... | 47,702 | [
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Potential for polyvalent infectious bronchitis vaccines. | Numerous antigenic types and subtypes of infectious bronchitis virus (IBV) have been isolated and characterized from field epornitics of infectious bronchitis (IB). Thus obvious failures in obtaining the necessary protection from vaccination have been documented and they underscore the urgent need for vaccines which st... | 47,726 | [
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Investigation into the relationship of M ulcerans to M. buruli and other mycobacteria. | The main characteristics of Mycoplasma ulcerans are its remarkably distinct drug sensitivity pattern and its rather poor enzymatic activity. M. microti is clearly distinguishable from M. bovis and M. tuberculosis. Some of the M. buruli strains appear to be identical with M. ulcerans, Whereas others show similarity eith... | 47,730 | [
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Replacement of class instruction in histology by audio-tape and booklet self-instruction sessions. | A system of self-instruction in histology is described, using audio-tape and booklet instruction to supplement the microscopical examination of tissue sections. A pilot test demonstrated a slight superiority in retention of knowledge among students using this system, compared with those in the conventional class. | 47,754 | [
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Activity, isoenzyme pattern, and synthesis of UDPglucose 4-epimerase during differtiation of Physarium polycephalum. | 1. The specific activity of UDPglucose 4-epimerase (EC 5.1.3.2) increases by about 50% during the first 24 h of starvation-induced differentiation (spherulation) of Physarum polycephalum. 2. At all stages during differentiation, the enzyme activity is very sensitive to actinomycin-C and cycloheximide, inhibitors of tra... | 47,762 | [
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A partial reaction in photosystem II: reduction of silicomolybdate prior to the site of dichlorophenyldimethylurea inhibition. | Silicomolybdate functions as an electron acceptor in a Photosystem II water oxidation (measured as O2 evolution) partial reaction that is 3-(3,4-dichlorophenyl)-1, 1-dimethylurea (DCMU) insensitive, that is, reduction os silicomolybdate occurs at or before the level of Q, the primary electron acceptor for Photosystem I... | 47,764 | [
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Axoplasmic transport of a brain-specific soluble protein. | The rate and extent of axoplasmic transport of the brain-specific soluble protein (14-3-2 protein) has been investigated in the avian visual system. 1-day-old chicks were injected monocularly with tritiated proline, Incorporation of the isotope into the 14-3-2 protein synthesized within the retina of the injected eye, ... | 47,766 | [
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Steroid-binding proteins in rabbit plasma: Separation of testosterone-binding globulin (TeBG) from corticosteroid-binding globulin (CBG), preliminary characterization of TeBG, and changes in TeBG concentration during sexual maturation. | Two distinct steroid-binding proteins are present in rabbit plasma. One of the proteins (TeBG) binds [3-H]5 alpha-dihydrotestosterone (5 alpha DHT) and [3-H]testosterone. The affinity of this binding protein for 5 alpha DHT was 3-4 times greater than for testosterone. Binding of [3-H]5 alphaDHT could be inhibited by un... | 47,821 | [
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Immunity to influenza. | Immunity to influenza virus may be considered from the standpoints of viral and hostfactors. Amonst viral factors the phenomena of antigenic 'shift' and 'drift' of the surface antigens. Hemagglutinin HA and neuraminidase NA, are of utmost importance in enabling the virus to combat host immunity and to produce recurrent... | 47,824 | [
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Studies on parainfluenza-3 virus neuraminidase. | Various parainfluenza-3 virus (PIV-3) strains differ in neuraminidase (NA) activity, some being neuraminidase strong (NAS) and some neuraminidase weak (NAW). No difference in the ability of these strains to elicit antibody activity to hemagglutinin (HA) or NA of PIV-3 was observed. Samples of formalin-treated PIV-3 rel... | 47,826 | [
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Plasma proteins in canine gastric lymph. | Because it has not been possible to collect gastric lymph by cannulation of lymph vessels, the methods of renal micropuncture were adapted to collection and analysis of 0.5- to 3-mu samples obtained by puncturing lymph vessels on or immediately adjacent to the ventral surface of the dog's stomach. Samples of gastric ly... | 47,827 | [
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Relationship of hepatitis B antigen in cirrhosis and hepatoma in Thailand. An etiological significance. | A study of 221 patients revealed that detectable hepatitis B surface antigen (HBS Ag) was found in 16.3% of 49 patients who had hepatoma associated with cirrhosis. None of the 8 hepatoma patients without cirrhosis had detectable HBS Ag in the serum. When known causes of cirrhosis were excluded, HBS Ag was present in 18... | 47,828 | [
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Cell-mediated immunity to moloney sarcoma virus in mice. I. Analysis of antigens responsible for lymphocyte stimulation in regressor mice. | Purified viruses, viral antigens, and cell extracts have been tested for their ability to stimulate protein synthesis by MSV-M-1 regressor spleen cells from BALB/c mice. Immune, but not normal cells, responded to MSV-M, but not to MSV-G virus-1, and to the type-specific viral envelope glycoprotein from MSV-M virus. Ext... | 47,841 | [
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Localization and characterization of carbohydrates in adrenal medullary cells. | The localization and characterization of carbohydrates in adrenal medullary cells were studied by histochemical and cytochemical methods. Adrenaline (A)-and noradrenaline (N)-storing granules were argentaphobic when ultrathin sections of Araldite-embedded medullae were stained according to the periodic acid-thiocarbohy... | 47,862 | [
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Olivocochlear and vestibular efferent neurons of the feline brain stem: their location, morphology and number determined by retrograde axonal transport and acetylcholinesterase histochemistry. | Anterograde degeneration studies have shown that the cochlear and vestibular receptor organs receive an efferent innervation from neurons in the brain stem. This pathway may provide a mechanism by which the CNS could modulate its own afferent input. The neurons which provide this innervation have so far escaped positiv... | 47,866 | [
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Histochemical localization of cytochrome oxidase in gastric mucosa. | A cytochemical technique for localizing cytochrome oxidase activity, based upon the oxidative polymerization of 3,3-diaminobenzidine (DAB) to an osmiophilic reaction product, has been employed to test the possibility of extramitochondrial cytochrome oxidase in gastric mucosa. Deposition of reaction product was found to... | 47,870 | [
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Functional heterogeneity of lymphocytic choriomeningitis virus-specfic T lymphocytes. I. Identification of effector amd memory subsets. | At varying intervals after immunizing infections of adult BALB/c mice with lymphocytic choriomeningitis (LCM) virus, splenic lymphocytes were tested for their ability to either elicit acute LCM or protect against lethal intracerebral LCM virus challenge when transferred to syngeneic recipients that were, respectively, ... | 47,887 | [
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Recognition by pregnancy serums of non-HL-A alloantigens selectively expressed on B lymphocytes. | A group of alloantibodies are found in pregnancy sera which react with antigens present on B lymphocytes and monocytes but are not detectable on the vast majority of unstimulated T cells. This specificity distinguishes them from HL-A antibodies which react with both cell types. They were readily recognized through indi... | 47,890 | [
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Normal serum-lipids in renal-transplant patients. | In contrast to previous reports, most patients (78%) with a successful renal transplant being followed up at the University of Kentucky Medical Center had a normal serum-lipid profile. The patients with hyperlipidaema (22%) had normal fasting insulin levels; they received similar immunosuppressive therapy but were sign... | 47,946 | [
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Doxycycline treatment and human infertility. | The role of mycoplasmas in infertility was studied in 120 couples. During the twelve months of the study 27 couples (22-5%) conceived. T mycoplasmas were isolated from 63% of these couples, and Mycoplasma hominis from 18%, compared with 56% and 13%, respectively, in those who did not conceive. 88, with primary infertil... | 47,949 | [
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Complement changes and disseminated intravascular coagulation in Plasmodium falciparum malaria. | Complement activation as shown by increased clearance of radioactive C1q and reduction in serum-C3 level was found in fifteen (83%) of eighteen patients studied during Plasmodium falciparum infection. Six patients had haemostatic defects suggesting disseminated intravascular coagulation (D.I.C.), and five others had ot... | 48,001 | [
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Atypical spherocytosis, a disease of spleen as well as of red blood-cells. | It is proposed that atypical spherocytosis is a result of severe spherocytosis combined with splenic dysfunction. The spleen exercises a "conditioning" effect on the red blood-cell but is insufficient in the "culling" and "pitting" functions. As a result, a large population of severely damaged erythrocytes is circulat... | 48,127 | [
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[Basophil leucocytes and hyperlipidemia (author's transl)]. | In explorations with 42 patients, who have got 2 g of fat per kg body weight, Heidsick, a member of our hospital, discussed quantitative and qualitative changing in basophil leucocytes in relation to the cholesterol and triglyceride content of the blood and the body weight. He showed, that there was an increase of baso... | 48,182 | [
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[Propafenon, a new antiarrhythmic agent for the treatment of ectopic and rapid cardiac arrhythmias (author's transl)]. | Propafenon (SA 79, Fenoprain, Baxarytmon) is a new antiarrhythmic agent with "quinidine-like" localanaesthetic direct membrane and beta adrenergic blocking actions. The drug was given to 50 patients with various types of cardiac arrhythmias. The effective and compatible dose was 70-140 mg administered intravenously in ... | 48,183 | [
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[Criteria for choice of therapeutic procedures in lymphomas]. | Surgery, high-energy radiotherapy and cyclic polychemotherapy are best indicated for the treatment of Hodgkin's disease and other forms of lymphoma. Overall evaluation will determine the most suitable management in each case. Clinical andpathological stage, the histological picture, the degree of vascular invasion and ... | 48,217 | [
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[Current problems in therapy of evolutive malignant granuloma. Our experience with a new scheme of polychemotherapy]. | Treatment of advanced Hodgkin's disease by associating vincristine, adriblastine, prednisone and procarbazine is compared with other widely employed protocols. Most subjects in the series had already received one or more drugs and had relapsed. In spite of this, 60% were still in complete remission one year after the a... | 48,218 | [
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Subacute thyroiditis. A diagnosis in otolaryngology. | Subacute thyroiditis is often unrecognized and patients may be treated for pharyngitis, laryngitis, otitis media or similar disorders connected with otolaryngology. It is conceivable that these patients may seek treatment in ENT departments. The difficulties encountered in making a correct diagnosis are illustrated her... | 48,224 | [
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[Value of calcium gluconate labelled with 99mTc in the detection of intracranial tumors]. | In a preliminary communication, the authors compare the success coefficients of pertechnate 99m-Tc and of a new labelled molecule: calcium gluconate 99m-Tc, in a group of 32 patients. The results obtained showed the undoubted superiority of the gluconate in comparison with the pertechnate in the detection of intracrani... | 48,229 | [
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Interspecies brain antigen detected by naturally occurring mouse anti-brain autoantibody. | Normal mouse sera contain naturally occurring antibodies that are cytotoxic in the presence of rabbit complement for NB1, a cell line derived from a neuroblastoma adrenal metastasis of a spontaneous ovarian teratoma. The anti-NB1 antibodies can be specifically removed from normal mouse sera by absorption of the sera wi... | 48,248 | [
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Oncornaviral protein modulation in mouse uterine tissue by estrogen (38467). | Treatment of ovariectomized NIH Swiss mice with estrogens elevated the level of the murine leukemia virus group specific protein and the activity of an RNA-directed DNA polymerase in the uterus. The extent that these markers were raised was dependent on the relative biological potency of the estrogen and on the time in... | 48,257 | [
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Replication of IPN virus: a cytochemical and biochemical study in SWT cells. | Although IPN virus failed to multiply at 30 degrees, it replicated at 16 degrees and 22 degrees in SWT cells. At 22 degrees the viral eclipse period lasted nearly 6 hr with maximal virion titers attained by 24 hr, whereas replication at 16 degrees was much slower. The replication of the virion was inhibited by 0.05 mug... | 48,260 | [
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Correlation of the critical micelle concentrations of surfactants with their effects on a bacterial demethylase. | The activity of a sarcosine dehydrogenase isolated from a strain of Pseudomonas is enhanced by the addition of Triton X-100, Brij 35, and Tween 80, and is inhibited by deoxycholate and Sarkosyl NL-97. 2,6-Dichlorophenolindophenol, which is used as the oxidant in the dehydrogenase assay, has also been employed as an ind... | 48,265 | [
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Turkey syndrome 65, oedema syndrome and Mycoplasma meleagridis. | Comparisons of liver histology and serum protein characteristics from cases of oedema syndrome and from poults with Mycoplasma meleagridis induced ascites revealed that the two conditions, though presenting grossly similar post mortem appearances, are different entities. Serum albumin concentrations, but not total seru... | 48,271 | [
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Glomerular antigen complexes associated with transitional cell carcinoma. | An immunofluorescent pattern consistent with glomerular complexes of tumor antigen bound to IgM antibody has been observed in a patient without clinical or pathologic evidence of renal disease. The findings support the thesis that tumors may shed antigen capable of eliciting an immune response which may or may not be a... | 48,285 | [
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An approach to experimental scleroderma, using urinary glycosaminoglycans from patients with systemic scleroderma. | As a result of intraperitoneal injections in mice of crude glycosaminoglycans obtained from the urine of patients with systemic scleroderma, a fibrotic process similar to the intial changes of human scleroderma was frequently observed, especially in the skin and esophagus when the glycosaminoglycans contained a probabl... | 48,324 | [
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Interactions in the uptake between catecholamines and estradiol in the human uterus. | Optimal conditions of pH, dose, time and temperature for the in vitro uptake of radioactivity from 3-H-E or 3-H-NE by the human endometrium and myometrium were established. Uptake was dependent on temperature but not on pH. Uptake of radioactivity from 3-H-NE was always higher (p smaller than 0.05) in both tissues than... | 48,342 | [
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Auto-tutorial method for teaching manual skills. | This paper describes a self-learning method for teaching craft and activity techniques developed by the faculty at St. Mary's Junior College, Minneapolis. The basic assumption is that, in order for learning to take place, the student must be actively involved in the learning-teaching process. Personalized instruction w... | 48,344 | [
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Mucous glands in the developing human nose. | In 56 fetuses the development and spread of the nasal glands were studied by three different whole-mount methods. Development starts anteriorly in the nose and proceeds with a given regularity backward. The anterior nasal, serous glands are found only most anteriorly in the nose. They are laid down in the 11th week by ... | 48,372 | [
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Acute myelogenous leukemia of the Wistar/Furth rat: establishment of a continuous tissue culture line producing lysozyme in vitro and in vivo. | A transplantable myelogenous leukemia of an inbred Wistar/Furth rat has been established in tissue culture and cloned. The resulting transplantable leukemia line demonstrates in vitro doubling time of 20 hr, colony-forming efficiency of 5% in liquid and methylcellulos-containing medium, and a saturation density of 3.0 ... | 48,387 | [
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Microscope fluorometric investigations on the reticulocytic maturation distribution as diagnostic criterion of disordered erythropoiesis. | A microscope fluorometric technique is described which permits not only the visual identification of reticulocytes under the fluorescence microscope but also the determination of their relative stage of maturation to normocytes. The technique is based on a specific staining procedure which results in a fluorescent comp... | 48,388 | [
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Evaluation of [3-H]proline for radioautographic tracing of axonal projections in the teleost visual system. | The efficacy of [3-H]proline radioautography for tracing retinal ganglion cell projections to the optic tectum of the jewel fish, Hemichromis bimaculatus, has been compared with that of degeneration techniques. There was good agreement between the various methods. Retinal projections to the optic tectum of two other te... | 48,408 | [
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Properties of prostatic cultures transformed by SV40. | SV-40-transformed hamster prostatic tissue has been previously evaluated as a model for human prostatic carcinoma. Because the original cell line was lost, Syrian golden hamster prostatic tissue has been established in explant culture and infected with a 10-6-cell tissue culture infectious dose (50 percent effective) o... | 48,416 | [
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Induction of the polyamine-biosynthetic enzymes in mouse epidermis by tumor-promoting agents. | A single topical application of 1.0 mg of crotol oil or 17 nmoles of 12-O-tetradecanoyl-phorbol-13-acetate (TPA) resulted in a rapid, transient stimulation of mouse epidermal ornithine decarboxylase activity. The activity reached a peak (230-fold greater than control after TPA) at 4 to 5 hr after croton oil or TPA trea... | 48,421 | [
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A quantitative electron microscopic analysis of the keratinizing epithelium of noral human hard palate. | The epithelium of normal human hard palate was subjected to sterologic analysis. Ten biosies were selected from a total of twenty specimens collected from 9 to 16 year old females, and processed for light- and electron microscopy. At two levels of magnification, electron micrographs were sampled from three strata (basa... | 48,425 | [
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The location of the genes coding for hexon and fiber proteins in adenovirus DNA. | A serological analysis has been made of the capsid antigens hexon and fiber from 17 Ad5-Ad2+ND1 recombinants that enables us to determine the phenotype of the recombinants. By correlation of this data with the genetic and physical maps of the adenovirus genome, obtained by recombination and restriction endonuclease ana... | 48,427 | [
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[New chemotherapy (adriamycin, belomycin and vincristin) of metastasizing malignant testicular teratoma (author's transl)]. | In a prospective study 18 patients with metastasizing testicular teratomas were treated with adriamycin, bleomycin and vincristin. Sixteen could be fully evaluated: 12 in stage IV (visceral metastases), three in stage III (lymphondular involvement beyond the diaphragm) and one with advanced stage II (iliac, para-aortic... | 48,459 | [
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Intraaticular treatment of tarsal degenerative joint disease in cattle. | Tarsal degenerative joint disease (DJD) in 12 cattle was classified as primary or secondary, based on age, evidence of hereditary or congenital joint conformation defects, faulty hindlimb alignment, duration and type of usage joints were subjected to, and history or signs of repeated trauma. Three of the cattle had bil... | 48,510 | [
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Primary interaction between antibody and components of Alternaria. I. Immunology and chemical characteristics of labeled antigens. | Components were isolated from Alternaria tenuis and its culture filtrate, and were radiolabeled with 123-I. The labeled antigenic components had a high polysaccharide content as determined by staining patterns following electrophoresis in polyacrylamide gels and by inactivation with sodium metaperiodate. A primary bind... | 48,526 | [
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Subtypes of hepatitis B surface antigen in Southeast Asia. | The prevalences of hepatitis B surface antigen (HBs Ag) subtypes in Thais, Cambodians, and Vietnamese were compared with the prevalences in Americans residing in Southeast Asia. HBs Ag was found with approximately equal frequency in Thai (43 percent) and American (39 percent) patients with hepatitis. However, higher pr... | 48,531 | [
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Salmonella typhimurium mutations conferring resistance to Felix O phage without loss of smooth character: phage attachment and immunochemical and structural analyses of lipopolysaccharides. | Salmonella typhimurium mutants, called Felix O-resistant (FOR), selected for resistance to phage Felix O (FO) which has its receptor in the core lipopolysaccharide (LPS), retain most of the properties of the smooth parent strain (MacPhee, Krishnapillai, Roantree & Stocker, 1975). LPS extracted from one parent and t... | 48,537 | [
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Quantitation of avian RNA tumor virus reverse transcriptase by radioimmunoassay. | A radioimmunoassay was developed that can detect and quantitate 3 ng or more of the avian RNA tumor virus reverse transcriptase. The assay detected no antigenic sites in Rous sarcoma virus alpha virions or in virions of a murine RNA tumor virus. About 70 molecules of reverse transcriptase were found per virion of avian... | 48,558 | [
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Scabies masquerading as dermatitis herpetiformis. | Scabies can be easily mistaken for dermatitis herpetiformis because the two conditions have features in common, namely, pruritic papules, vesicles, and crusted erosions in the sacral and gluteal regions. In five patients with scabies who were initially judged clinically to have dermatitis herpetiformis, histological ex... | 48,563 | [
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Androgen-induced hepatoma. | Three cases of hepatocellular carcinoma are reported in young men who had been taking androgenic-anabolic steroids. The tumours were histologically similar to those described in previous reports. The tumour progressed slowly in two patients during four and seven years of observation, but in the latter bony metastases o... | 48,615 | [
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Gastric-acid output, pepsin output, and lean body mass in normal and duodenal-ulcer subjects. | Gastric-acid output bears a significant relationship to parietal cell mass and to lean body mass. The relationships of pepsin output to gastric-acid output and to lean body mass have been investigated in 13 normal subjects and 40 duodenal-ulcer patients. Peak pepsin output (P.P.O[I]) was stimulated by insulin-induced h... | 48,672 | [
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Nucleoside-phosphorylase deficiency in a child with severely defective T-cell immunity and normal B-cell immunity. | A 5-year-old girl with a history of recurrent infection and anaemia has no measurable purine nucleoside phosphorylase (N.P.) activity in her red blood-cells. Her serum-immunoglobulin levels are normal, as are her antibody responses to thymus dependent and independent antigens. However, she has severe lymphopenia, prono... | 48,676 | [
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0.1539385,
0.3225545,
0.1811714,
0.1752208,
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-0.116507... |
Lymph-node biopsy during simple mastectomy. | The distribution of pectoral (external mammary) nodes identified during the operation and removed with the axillary tail of the breast was studied in 45 patients treated by simple (total) mastectomy. Up to 13 nodes may lie within the axillary tail, and these are continuous with the pectoral nodes. Lymph-nodes were iden... | 48,724 | [
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Antibody to cultured human insulinoma cells in insulin-dependent diabetes. | Circulating antibodies to live tissue-cultured human-insulinoma cells were identified in 34 out of 39 insulin-dependent diabetic patients by an indirect immunofluorescent technique. The antibodies were unrelated to insulin therapy since 8 of 9 sera obtained before insulin-replacement treatment were antibody positive an... | 48,725 | [
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0.0994806... |
Ultrasound in the diagnosis of spina bifida. | Three patients who were at risk of having a baby with a neural-tube defect were investigated by ultrasonic examination and alpha-fetoprotein (A;F.P.) estimation. In all three cases amniotic-fluid A.F.P. levels were significantly raised and pregnancy was terminated. In the first case ultrasound failed to detect a small ... | 48,732 | [
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Rubella-virus infection in juvenile rheumatoid arthritis. | Antibody activity against mumps, measles, polio, and rubella viruses was determined in patients with juvenile rheumatoid arthritis (J.R.A.), rubella-vaccine associated arthritis, adult rheumatoid arthritis, other chronic systemic disorders (e.g., systemic lupus and dermatomyositis), and in a matched population of norma... | 48,775 | [
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Grey-scale ultrasonography for monitoring industrial exposure to hepatotoxic agents. | Industrial exposure to several potentially hepatotoxic agents, such as vinyl-chloride monomer may occur, and there is a need for non-vasive, diagnostic techniques to detect and monitor progressive pathological processes in liver or spleen. Grey-scale ultrasonography permits display of detailed anatomy and pathology in ... | 48,839 | [
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Porcine streptococci causing meningitis and septicaemia in man. | From 1968 to 1974 seven cases of septicaemia and purulent meningitis caused by porcine streptococci of the Lancefield group R and three cases caused by similar streptococci lacking R antigen occurred in the Netherlands. Bacteria isolated from all ten patients shared the characteristics of a biochemically well defined b... | 48,908 | [
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Effect of intravenous B.C.G. in guineapigs and pertinence to cancer immunotherapy in man. | Intravenous injection of heat-killed or irradiated B.C.G into tuberculin-positive guineapigs produced macroscopic lesions in the lung when examined 10 days or 4 or 6 weeks later. Microscopically, granulomas typical of a delayed hypersensitivity reaction were seen. Intravenous B.C.G. in normal guineapigs did not produce... | 48,944 | [
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Infection caused by Proteus mirabilis strains with transferrable gentamicin-resistance factors. | During a period of 10 weeks, four patients in one hospital became infected with gentamicin-resistant Proteus mirabilis. In two of them septicaemia associated with indwelling catheters developed, one had urinary tract and wound infections, and in the fourth patient the organism was isolated from a superficial wound. The... | 48,945 | [
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[Transurethral electroresection of prostatic adenoma (author's transl)]. | The affliction of disturbances of the voidance of urine in aging men is becoming an ever more frequent medical problem because of the rising life expectancy of our population. The cause of the urinary obstruction is fibromyoadenomatosis of the paraurethral glands which may develop at any time after the age of 40. Trans... | 49,013 | [
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0.1080182,
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Diabetes mellitus: changes in the transport properties of isolated intestinal microvillous membranes. | Isolated, small intestinal microvillous membranes from normal and acutely diabetic rats were compared with respect to D-glucose transport. D-Glucose was accumulated to a greater extent by diabetic membrane vesicles when supplied with energy in the form of a NaC1 or a NaSCN gradient across the vesicle membrane. The diff... | 49,051 | [
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0.07554227,
0.04753245... |
Complement components in normal serum and plasma quantitated by electroimmunoassay. | Sjöholm, A. G. Complement Components in Normal Serum and Plasma Quantitated by Electroimmunoassay. Scand. J. Immunol. 4, 25-30, 1975. The concentrations of C1q, C1s, C3, C4, C5, C3 proactivator, and C1 inactivator in serum and EDTA plasma from 100 normal adults were determined by electroimmunoassay. The normal range of... | 49,076 | [
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... |
Variability of dermal elastin visualized ultrastructurally with iron hematoxylin. | The Verhoeff iron hematoxylin-lead citrate (VIH-LC) method demonstrated vertical elastic fibers that were often composed only of microfibrillar component extending into the epidermal basement membrane in human skin. These fibers connected with a network of trabeculae composed of microfibrils and elastin fibrils in vary... | 49,149 | [
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Adverse reactions to intravenous anaesthetics. | One hundred consecutive reports of reactions to intravenous anaesthetics Althesin, thiopentone and Epontol are reviewed and analysed. Ten reactions are attributed to causes other than the anaesthetic drug, and four are believed to have been caused by the muscle relaxant employed. The remaining 86 reactions were grouped... | 49,189 | [
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Molecular conformation of bovine A1 basic protein, a coiling macromolecule in aqueous solution. | Aqueous solutions of bovine A1 protein, the major component of the basic protein fraction of myelin, were studied by small angle X-ray diffraction. The experimentally determined molecular weight, 17,800, is within 3% of that corresponding to the amino acid sequence, 18, 395, and the radius of gyration was found to be 4... | 49,193 | [
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Current-voltage studies on the thylakoid membrane in the presence of ionophores. | The reversibility of the binding of ionophores to the thylakoid membrane is studied. While gramicidin binds practically irreversibly, valinomycin and nonactin bind reversibly, however, only a small fraction (about 1%) of the membrane-bound valinomycin or nonactin is active in ion transport. The current-voltage relation... | 49,197 | [
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Serum ferritin assay and iron status in chronic renal failure and haemodialysis. | Forty-four patients with chronic renal failure on haemodialysis for four months to eight years were studied. All recieved intravenous iron dextran 100 mg on alternate weeks. Serum ferritin concentrations correlated well with body iron stores estimated by grading the bone marrow stainable iron. Altogether 34 patients sh... | 49,205 | [
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[Whipple's disease]. | Whipple's disease is characterized morphologically by macrophages in the small intestine which store PAS-postive material, as well as coarsening and atrophy of the intestinal villi, with pseudocystic cavitations. Without treatment it ends fatally due to irreversible diarrhoea and cachexia. Until 1963, only 90 cases h... | 49,262 | [
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Immunological comparison of basic encephalitogen and histone F2A1. | The extent of immunological cross-reaction between basic encephalitogen and histone F2A1 on both the humoral antibody level and on the cellular level has been established. The extent of humoral cross-reaction was tested by direct complement fixation employing both anti-histone F2A1 and antisera to basic encephalitogen,... | 49,268 | [
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Mammalian chromosome identification in interspecific hybride cells using "Hoechst 33258". | Treatment of fixed chromosome preparations of mouse-human hybrid cells with the benzimidazol derivative "Hoechst 33258" makes it possible to distinguish between mouse and human chromosomes. Treatment of live cells results in differential condensation of mouse and human centromeric regions. The effects of the dye on a m... | 49,289 | [
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The histochemistry and structure of tentacle cartilage tissues in the marine polychaete, Sabella melanostigma. | The cartilages (or "chondroid" tissue) in tentacles of the polychaete annelid, Sabella melanostigma, have been examined by electron microscopy and a series of histochemical techniques for the demonstration of mucopolysaccharides and protein end-groups. The ultrastructural studies indicated that the cartilages possess a... | 49,336 | [
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A study of the distribution of chromaffin-positive (CH+) and small intensely fluorescent (SIF) cells in sympathetic ganglia of the rat at various ages. | Small intensely fluorescent (SIF) and chromaffin-positive (CH+) cells were independently investigated by formol-induced fluorescence and by chromaffin techniques in the superior cervical, thoracic and coeliac-mesenteric ganglia of neonatal (2--10 days), adolescent (2--4 months) and adult (6--15 months) rats. Identifica... | 49,346 | [
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The binding of cationized ferritin at the surfaces of ehrlich ascites tumor cells: the effect of pH and glutaraldehyde fixation. | The densities of cationized ferritin (CF) particles binding to the surfaces of cultured Ehrlich ascites tumor cells were determined at pH 7.4, where the ferritin stain was applied either prior to or following glutaraldehyde fixation. The densities were also determined with CF adjusted to pH 1.9 and applied after fixat... | 49,356 | [
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Changes with age in protein-bound iodine (PBI) and body temperature in the mouse. | Protein-bound iodine (PBI), body temperature, and the response of the thyroid gland to different doses of thyrotropin (TSH) were examined in males of two inbred strains of mice at different ages. Results indicate persistent decline in PBI with advancing age that is significantly greater in DBA/2J than C57BL/6J mice. Th... | 49,375 | [
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... |
Serodiagnostic application of immunohistoperoxidase reactions on antigen-coupled agarose beads. | Agarose beads to which antigens were covalently bound were subjected to indirect immunohistoperoxidase procedures. For detection and titration of serum antibodies against bovine gamma globulin (BGG) this method appeared to be specific and sensitive. One advantage is that no special instruments are needed. As an example... | 49,378 | [
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A radioimmunoassay of cellular surface antigens on living cells using iodinated soluble protein A from Staphylococcus aureus. | Soluble protein A from Staphylococcus aureus does carry great promise as a marker for cellular surface determinants, due to its specific reaction with, and high affinity for, most subclasses of mammalian IgG. In this article we present the different parameters involved in a radioimmunoassay using 125-I-labelled protein... | 49,379 | [
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... |
Immunological analysis of plasminogen activators from normal and transformed hamster cells. Evidence that the plasminogen activators produced by SV40 virus-transformed hamster embryo cells and normal hamster lung cells are antigenically identical. | Rabbits were immunized against the plasminogen activator released by SV4- virus-transformed hamster embryo cells. The resulting antiplasminogen activator immunoglobulin (APA-IgG) inhibited the enzymatic activity of the plasminogen activator produced by SV40-transformed hamster cells, and the plasmin-catalyzed release ... | 49,388 | [
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... |
Trisomy 22. Two new cases and delineation of the phenotype. | Two unrelated children, not affected with Down's syndrome, with strikingly similar phenotypes and an extra G-like chromosome are presented. Quinacrine and trypsin-Giemsa banding identified the extra chromosome as No. 22. The phenotype of these patients and the review of 15 additional similar cases from the literature p... | 49,427 | [
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-0.4259413,
... |
A patient with congenital anomalies and a deletion of the long arm of the long arm of chromosome 4 [46,XY,del(4)(q31)]. | This paper describes the clinical symptoms and cytogenetic findings in a patient previously described in a doctoral thesis (van Kempen, 1969). The patient is a boy with multiple congenital anomalies and a deletion of the long arm of chromosome 4. A recent Giemsa banding study showed absence of the terminal G-band, as w... | 49,428 | [
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0.137272,
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0.361559,
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0.05927527,
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0.388321,
0.2981964,
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0.14... |
T-mycoplasmas: a study of the morphology, ultrastructure and mode of division of some human strains. | The morphology of 10 strains of T-mycoplasma was studied in wet preparations of viable cells by darkfield, phase-contrast and interference microscopy, and in fixed preparations by various techniques of electron microscopy. Mycoplasma-like artefacts in the horse-serum component of the medium were eliminated by filtratio... | 49,431 | [
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0.698514,
0.08216758,
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0.14... |
Inhibition of viral transcriptase by immunoglobulin directed against the nucleocapsid NS protein of vesicular stomatitis virus. | In search of an anti-transcriptase, antibody was raised in rabbits to partially purified, soluble NS protein present in cytoplasmic extracts of cells infected with the Indiana serotype of vesicular stomatitis (VSInd) virus. This antiserum gave specific reactions of identity by agar immunodiffusion with both cytoplasmic... | 49,440 | [
0.01111756,
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0.01686879,
0.2069705,
0.4398244,
0.001237331,
0.09846276,
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0... |
Interspecies antigenic determinants of the reverse transcriptases and p30 proteins of mammalian type C viruses. | The major internal structural proteins (p30) of type C viruses isolated from several mammalian species were studied by radioimmunoprecipitation and competitive radioimmunoassays. Three antigenically distinguishable sets of interspecies determinants could be demonstrated by both methods. One set of determinants shared b... | 49,443 | [
0.06260286,
0.08635293,
0.00974643,
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0.003611856,
0.01419577,
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Prevention of fatal postoperative pulmonary embolism by low doses of heparin. An international multicentre trial. | The efficacy of low-dose heparin in preventing fatal postoperative pulmonary embolism has been investigated in a multicentre prospective randomised trial. 4121 patients over the age of forty years undergoing a variety of elective major surgical procedures were included in the trial; 2076 of these were in the control gr... | 49,649 | [
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0.1923099,
0.1600349,
0.07252988,
0.4740208,
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0.... |
Local production of specific IgE antibodies in allergic-rhinitis patients with negative skin tests. | A group of patients with allergic rhinitis had a clinical history strongly suggestive of house-dust-mite (Dermatophagoides pteronyssinus) allergy but negative skin reactions when prick tested with D. pteronyssinus extracts. These patients were proved to be clinically allergic by nasal provocation with this allergen. Al... | 49,744 | [
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0.1769919,
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0.05639554,
0.07558685,
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Reduction in severity of acute renal failure in rats by beta-adrenergic blockade. | The effectiveness of beta-adrenergic blockade in preventing acute renal failure (A.R.F.) in rats was studied in the hypoxia model produced by unilateral nephrectomy and clamping of the contralateral renal artery for 70 minutes. Beta-adrenergic blockade effectively reduced the severity of A.R.F. in this experimental mod... | 49,748 | [
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0.03782289,
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0.01265427,
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Electrolyte disturbances in beer drinkers. A specific "hypo-osmolality syndrome". | A syndrome is described which affects subjects whose consumption of beer is considerable but who take no or little ordinary food. The symptoms include fatigue, dizziness, and muscular weakness; the biochemical changes are hyponatraemia and hypokalaemia. The disorder is rapidly resolved by stay in hospital. Beer is poor... | 49,796 | [
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Cytogenetic effect of bleomycin on human leukocytes in vitro. | Human leukocytes treated with bleomycin (BLM) for clinical use, at concentrations of 0.1, 0.5, 1.0, 10 and 50 mug/ml were studied. Both chromosome- and chromatid-type aberrations were observed. The groups of larger chromosomes were more affected at every concentration. At dosages from 0.1 to 10 mug/ml no significant di... | 49,848 | [
0.09431843,
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0.2807635,
0.4292691,
0.3646884,
0.2745034,... |
Immunoaffinity chromatography of human beta-hexosaminidase A. | A highly specific method for the purification of human beta-hexosaminidase A employing immunoaffinity chromatography is described. Using an antiserum against the unique antigenic determinant, alpha, of beta-hexosaminidase A, and elution with 8.0M urea, a 283-or 417-fold purification of the enzyme was obtained in a sing... | 49,891 | [
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0.2807279,
0.2397559,
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0.1... |
[Activity of the hypophyseal-thyroid gland system in relation to the funcitonal state of the sex glands. Report I]. | Experiments were conducted on intact female rats; it was revealed that the content of protein-bound iodine (PBI) in the blood depended on the stage of the estral cycle. It was decreased at the metestrus and diestrus stages. Castration produced an even greater reduction in the blood PBI content. The blood PBI content... | 49,893 | [
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0.07208934,
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0.2507028,
0.0433857,
0.152055,
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... |
[Demonstration of cells of myothelial origin in canine mammary tumours by special staining methods (author's transl)]. | Three recent staining methods, the TPA-, TPL-, and TPT-method, were used to demonstrate cells of myothelial origin in mammary gland tumours in bitches and were compared with older techniques. The newer methods proved more suitable for demonstration of myofibrils in myothelial cells. With these techniques it is possible... | 49,985 | [
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0.137777,
0.5036731,
-0.09202349,
-0.1695638,
... |
[Vital fluorescent staining of microorganisms by 3',6'-diacetyl-fluoresceine for determination of their metabolic activity (author's transl)]. | By fluorescent microscopy and spectroscopy studies involving micro-organisms which were either viable or devitalised by heat sterilisation or gamma irradiation and could not be cultured any more, fluorochrome binding with 3' , 6'-diacetyl fluorescein was shown to be linked with the viability of a cell and a function of... | 49,989 | [
0.09120456,
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0.1082349,
0.003249262,
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0.06957376,
-0.0126931,
0.447944,
0.4303602,
0.1981576,
-0.1279627,... |
Hydralazine-induced lupus erythematosus-like syndrome. | A reversible syndrome resembling systemic lupus erythematosus and induced by hydralazine hydrochloride therapy is a well-recognized phenomenon in adults but does not seem to have been reported in children. A 9-year-old girl had fever, arthralgias, modest joint swelling, splenomegaly, antinuclear antibodies (ANAs), anit... | 50,009 | [
-0.1338881,
0.1968016,
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0.2078744,
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0.01892076,
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0.061993,
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0.2730823,
0.09462497,
0.08174705,
-0.4980141,
0.0... |
Presence of two virus-like particles in Penicillium citrinum. | Two icosahedral virus-like particles (28 and 19 nm in diameter, respectively) have been detected in sporogenic and asporogenic segregants of a strain of Penicillium citrinum. The distribution of the two particles differed among the two segregants. | 50,049 | [
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0.1753363,
0.2796344,
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... |
Intestinal lymphangiectasia. Long-term results with MCT diet. | The clinical course of 6 children with primary intestinal lymphangiectuasia who have been treated with low fat medium chain triglyceride-supplemented diets for between 3 and 8 years (4 for longer than 5 years) is described. Though laboratory findings indicate continuing chyle leak, evidence for long-term benefit from d... | 50,050 | [
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0.3328051,
0.1285387,
0.3603051,
-0.07535242,
... |
[Formation of elastic fibers around basal cell carcinomas: light microscopical observations (author's transl)]. | From 275 specimens of all sorts of basal cell epitheliomas the new formation of elastic fibers was histologically investigated by means of selective elastic tissue stains such as orcein and resorcinfuchsin. In nearly one third of the basal cell epitheliomas newly formed elastic fibers could be observed in the stroma. I... | 50,052 | [
0.1023572,
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0.2494322,
0.3293996,
0.1524713,
-0.1149511... |
Conformational and spectral analysis of the polypeptide antibiotic N-methylleucine gramicidin S dihydrochloride by nuclear magnetic resonance. | The 220-MHz proton magnetic resonance spectrum of the cyclic decapeptide antibiotic, mono-N-methylleucine gramicidin S, is reported and all the resonances have been assigned to specific protons of the constituent amino acids. Three methods--temperature dependence and solvent mixture (methanol-trifluoroethanol and dimet... | 50,084 | [
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0.3266015,
0.0784611,
0.3510792,
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... |
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