title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Cell differentiation in isolated inner cell masses of mouse blastocysts in vitro: onset of specific gene expression. | Inner cell masses (ICMs) were isolated by immunosurgery from giant blastocysts formed by the aggregation of three morulae. A layer of endoderm cells formed on the outer surface of these primary ICMs in vitro. When this layer was removed by immunosurgery, a secondary endoderm layer formed. Alphafetoprotein (AFP) was use... | 94,085 | [
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[Value of radiological investigations in patients with dysuria after prostatic adenomectomy (author's transl)]. | Dysuria is a relatively frequent complication after prostatic adenomectomy. The authors review 107 patients with this complication and demonstrate that radiological investigation, including a micturition study, preferably after IVU, shows the presence of an obstructive cause for the dysuria in the vast majority of case... | 94,093 | [
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Demonstration of an analogue to human pregnancy zone protein in the African green monkey. | A serum protein in the grivet (Cercopithecus aethiops), immunologically cross-reacting with human pregnancy zone protein (PZP), is found in males as well as in nonpregnant females. The electrophoretic mobility, antigenic cross-reactivity, molecular weight, and carbohydrate structure appear analogous to PZP; however, co... | 94,099 | [
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[Palliative chemotherapy with 5 FU and CPM in cancer of the prostate with bone metastases resistant to oestrogens. A clinical trial (author's transl)]. | The efficacy of an association of cyclophosphamide (CPM) and 5-fluorouracil was studied in 15 patients with prostate cancer not responding to oestrogen therapy, and more particularly its effect on pain due to bone metastases. No objective improvement was noted with this association, but there was a definitite reduction... | 94,108 | [
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Effects of intra-arterial bradykinin and substance P on isolated, blood-perfused small intestine of the rat. | Experiments were conducted on rat isolated, small intestine perfused at a fixed flow rate through the superior mesenteric artery with arterial blood from a donor rat, to determine the responses of the ileum to different peptides. Drugs were closely injected into the superior mesenteric artery. Single injections of brad... | 94,115 | [
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Advanced male non-seminomatous germ-cell tumours. Combination chemotherapy with cis-platinum, vinblastine and bleomycin. | Nineteen men with advanced germ-cell tumours were treated with a combination of vinblastine, bleomycin and cis-diamminedichloroplatinum II (cis-platinum). One patient died nine days after starting chemotherapy. Seventeen patients responded to therapy (14 completely and three partially). Toxicity was very high, and thre... | 94,148 | [
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Conversion of 3H-testosterone to dihydrotestosterone in human hypertrophic prostatic tissue. | The aim of the study was to develop a simple method for the determination of the conversion of testosterone to 5 alpha-dihydrotestosterone (5 alpha-DHT) after incubation of human hypertrophic prostatic tissue with 3H-testosterone. The mean conversion rate of 3H-testosterone to 5 alpha-DHT in hypertrophic prostatic tiss... | 94,161 | [
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Separation of the isoenzymes of glyoxalase I from human red blood cells by electrophoresis and isoelectric focusing on polyacrylamide gel and by ion exchange chromatography. | Methods have been devised for the separation of the isoenzymes of glyoxalase I(S-lactoylglutathione methylglyoxal-lyase (isomerizing), EC 4.4.1.5) from human red blood cells by electrophoresis and electrofocusing on polyacrylamide gel slabs. Three different staining methods were used for the location of the enzyme. Thr... | 94,203 | [
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Studies on fibronectin in the skin. III. Indirect immunofluorescence studies in lichen planus. | Fibronectin is a glycoprotein which is responsible for a varity of functions in the human organism, such as mediation of contact between cells and between cells and fibres, opsonic qualities, interaction in the stabilization of fibrin, etc. Fibronectin is an important constituent of the ground substance having a specia... | 94,206 | [
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Ultrastructural study of mechanobullous desquamative gingivitis: a case report. | A 67-year-old female with localized bullous desquamative gingivitis is described. Ultrastructural studies of the perilesional area showed changes similar to those seen in cicatricial pemphigoid and epidermolysis bullosa acquisita. | 94,213 | [
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Mixed bullous disease with labile erythrocyte sedimentation rate. | A woman, aged 66, fulfilled all the usual criteria of dermatitis herpetiformis. Subsequently, she developed circulating IgA and IgM basement membrane zone antibodies, a labile erythrocyte sedimentation rate (ESR), and the clinical picture changed to one of bullous pemphigoid. Her labile ESR was obviously caused by a fa... | 94,214 | [
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Subpopulations of human peripheral blood cells: analysis of granulocytic progenitor cells by flow cytometry and immunologic surface markers. | Normal human peripheral blood cells were separated into different populations based upon isopycnic sedimentation, E rosetting, and EAC rosetting. Each population was characterized according to morphology, surface markers, granulocytic colony formation in semi-solid media, and stainable RNA content by acridine orange (A... | 94,243 | [
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Efficiency and safety of methidathion applied as a pour-on systemic insecticide for control of cattle lice. | Methidathion applied to cattle as a pour-on insecticide for control of lice (predominantly Linognathus vituli, but also Haematopinus eurysternus and Damalinia bovis) caused a reduction in the lice population of approximately 98% to 99% in laboratory trials at the minimum recommended dose of 4 mg/kg and a 98.8% to 100% ... | 94,259 | [
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Phosphorescence of protein-bound eosin and erythrosin. A possible probe for measurements of slow rotational mobility. | We used a pulsed dye laser working at 540 nm to excite triplet-state formation of eosin and erythrosin, either bound or unbound to bovine serum albumin, in aqueous solution anaerobically at pH 8 and 20-22 degrees C. Delayed emission from radiative transitions of the triplet state was readily detectable, both as delayed... | 94,265 | [
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The kallikrein-kinin system in blood pressure homeostasis. | 1. The acute effects of the kallikrein inhibitor aprotinin (498 ki.u./min), and the kininase II inhibitor SQ 14,225 (250 MICROGRAM), GIVEN INTRAVEnously during saralasin-induced angiotensin blockade, were studied in conscious sham-operated rats and rats with benign and malignant two-kidney, one-clip Goldblatt hypertens... | 94,277 | [
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The identification of human H-Y antigen and testicular transformation induced by its interaction with the receptor site of bovine fetal ovarian cells. | beta 2m(-), HLA (-) Daudi human male Burkitt lymphoma cells excreted a group of protein subunits that shared three distinctive characteristics; their conspicuously longer half-lives compared to more hydrophilic Daudi excreted proteins, their tendency to form progressively larger polymers by means of interchain disulfid... | 94,287 | [
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Methylprednisolone sodium succinate treatment in global ischemia of the cat isolated heart. | Effects of methylprednisolone were studied on isolated, blood-perfused cat hearts subjected to 1 hr of normothermic ischemic arrest. Untreated hearts sustained decreases in peak ventricular pressure pulse, dP/dt, and ventricular compliance. Ischemic hearts also became edematous, gained sodium, and lost potassium and cr... | 94,382 | [
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Effect of endothelial damage on prostaglandin synthesis by isolated perfused rabbit mesenteric vasculature. | Isolated perfused rabbit mesenteric blood vessels selectively metabolized arachidonic acid to prostacyclin (prostaglandin I2). However, the less lipid soluble prostaglandin endoperoxide (PGH2) administered exogenously was not metabolized by vascular prostacyclin synthetase but was partially degraded to prostaglandin E2... | 94,398 | [
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Correlation between pharmacokinetics and intropic and electrophysiologic responses to digitoxin in the intact dog. | We attempted to correlate inotropic and eletrophysilogic digitoxin effects with serum digitoxin concentrations during 8 hr after a single dose. Eight pentobarbital-anesthetized Labrador dogs were given 2.0 mg digitoxin intravenously. Left heart catheterization and His bundle registration were performed. acing and progr... | 94,409 | [
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Effect of subminimal inhibitory concentrations of mecillinam on the synthesis of DNA, RNA, and protein of Salmonella typhimurium: a proposed mechanism of action. | Salmonellae alter their rod-like morphology to become large ovals within 3-5 hr after being exposed to concentrations of mecillinam below the minimal inhibitory concentration. Before this overt morphologic change occurs, synthesis of DNA increases, with a concomitant decrease in total protein synthesis. Incorporation o... | 94,451 | [
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Serological evidence of human leptospirosis in northern Greece. | a) 1069 human blood samples were tested for the presence of C. F. antibodies to leptospirae. 98 of these sera were from patients suffering from Weil's syndrome. 13 out of 98 patients were found to be suffering from leptospirosis; one of these died. 460 sera were from patients with febrile (acute) illness of unknown ori... | 94,493 | [
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Induction of interferon and radioprotective activity of polyriboguanylic-polyribocytidylic acid complex in mice. | The effect of polyriboguanylic-polyribocytidylic acid complex was investigated against acute X- and prolonged 60Co-gamma irradiation. Prophylactic administration of the polyribonucleotide complex increased endogenous spleen colony formation and the percentage of survival of irradiated BALB/c mice. The most pronounced e... | 94,503 | [
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Fluorescence-activated separation of cervical abnormal cells using herpesvirus antigenic markers. | Antisera to total HSV-2 (G) viral antigens (Ra-2) and to increasingly purified viral antigenic fractions ("crude" and "pure" AG-e) specifically stain HSV-2-(G)- or HSV-1-(F)-infected HEp-2 cells in indirect immunofluorescence. Anti-"crude" AG-e sera induced by HSV-1 (F) or HSV-2 (G) produce a single precipitin band of ... | 94,520 | [
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Potentiation and inhibition of ganglionic transmission by ruthenium red. | The effect of ruthenium red, 2.5 to 5 muM, on ganglionic transmission in rat superior cervical ganglia and frog abdominal ganglia were studied in vitro. In rat ganglia, ruthenium red caused a spontaneous firing of ganglia cells, and an increase in the amplitude and duration of the compound action potential following a ... | 94,531 | [
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Properties of Border disease virus as studied in a sheep cell line. | A fetal lamb muscle cell line has been isolated in which two strains of Border disease virus replicate well and induce a clear-cut cytopathic effect, thus providing a sensitive and practical assay system for both the virus and neutralizing antibodies. This system enabled us to study some characteristics of Border disea... | 94,539 | [
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Immune retention: immunological requirements for maintaining an easily degradable antigen in vivo. | Radioactive human serum albumin (125I-HSA) was injected into the hind foot pads of unimmunized mice, actively immunized mice and mice passively immunized with mouse or rabbit anti-HSA serum. Eleven days later the unimmunized mice had cleared most of the 125I-HSA. In contrast, a high concentration of 125I-HSA was retain... | 94,545 | [
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The pharmacodynamics of 4-(p-chlorophenylthio)butanol (W-2719) in humans. | 4-(p-Chlorophenylthio)butanol (W-2719) is absorbed, metabolized and excreted when administered orally to human volunteers. The butyrate (W-2718) and the acetate (W-2683) metabolites were found in plasma with W-2683 being the major biotransformation product and detectable seven days after administration with an apparent... | 94,548 | [
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0.2143751,
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0.2438645,
-0.07733224,
0.5715219,
-0.1473559,
0... |
Genetic modulation of RNA metabolism in Drosophila. IV. Measurement of rats of RNA synthesis by density labeling. | Accumulation of RNA was measured in adult males of two genotypes: car bb/Ybb- and car bb/YbbSuVar-5. The two genotypes have similar amounts of rDNA, which is reduced in comparison to wild type (CLARK, STRAUSBAUGH and KIEFER 1977). Although genotypically bobbed, car bb/YbbSuVar-5 flies have a wild-type phenotype; car bb... | 94,570 | [
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Oral rehabilitation by prosthetic restoration after maxillectomy for malignant tumors. | In maxillectomy patients, speech intelligibility between before and after insertion of prostheses has been reviewed by many investigators. Speech intelligibility was not related to the size of the defect, but rather to the defect region. Speech intelligibility was considerably improved by the use of prostheses. A great... | 94,595 | [
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Evaluation of indapamide in the treatment of hypertension. | A randomized double-blind, crossover trial was carried out in twenty hypertensive patients to evaluate the hypotensive efficacy and safety of indapamide. Indapamide in doses of 2.5 mg per day in combination with other antihypertensive agents was as effective in reducing the blood pressure in hypertensive patients as on... | 94,616 | [
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Isolation and characterization of free and membrane-bound polyribosomes from rabbit spinal cord. | A procedure is described for the preparation of free and membrane-bound polyribosomes from rabbit spinal cord. First, myelin and filaments are floated away from other subcellular components. The latter are then fractionated by differential centrifugation followed by sedimentation through a discontinuous sucrose gradien... | 94,644 | [
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Improved B cell typing for HLA-DR using nylon wool column enriched B lymphocyte preparations. | A rapid, simple procedure for preparing B lymphocytes using nylon wool has been devised. When mixtures of T lymphocytes, B lymphocytes, and monocytes are applied to nylon wool columns, B lymphocytes can then be removed, virtually free of monocytes. Such preparations (Ad) are 85 +/- 6% SIg+ and have only 3 +/- 1% monocy... | 94,704 | [
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Keratinization of the conjunctiva. | Keratinization of the tarsal conjunctiva in an eye with adequate tears occurs following a number of conditions, including irritation and sensitivity to topical medications, Stevens-Johnson syndrome, radiation to the lid, and occasionally from unknown causes. The keratinized cells produce an epithelial keratitis with su... | 94,716 | [
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Effect of cyproterone acetate on the genital organs of female rats. | Effects of cyproterone acetate, a synthetic steroidal compound, on the reproductive organs of female rats have been investigated. This agent causes reduction in ovarian weights indicative of suppression of pituitary gonadotrophins. Oestrogenic nature of cyproterone acetate was investigated in intact and ovariectomized ... | 94,736 | [
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Transferable drug resistance of Escherichia coli isolated from infant diarrhoea. | The resistance to several drugs was determined in 29 pathogenic strains of Escherichia coli (026, 055 and 0111) isolated from infant diarrhoea and 18 non-pathogenic E. coli strains isolated from the same individuals. Both pathogenic and nonpathogenic strains were resistant to at least 1 to 10 drugs, but only in four ca... | 94,745 | [
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Fungal nucleic acids as interferon inducers. | Nucleic acids isolated from the fungi Aspergillus niger x11, Piptoporus betulinus and Ganoderma applanatum reduced the number of vaccinia virus plaques in chick embryo fibroblast (CEF) tissue culture and when administered intravenously to white mice protected them against lethal infection with tick borne encephalitis v... | 94,746 | [
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Occurrence and distribution of rhizobiophages in Indian soils. | Soil samples from 30 fields in neighbouring districts of Varanasi were screened for rhizobiophages on 60 Rhizobium strains. Plaques were observed on five strains: P1, P5, SU391 (R. leguminosarum), CB756 and 32H1 (Rhizobium sp.). Rhizobiophages infective on one or more of the five strains were present in all fields. The... | 94,751 | [
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Serological relationships between Robinia mosiac, clover blotch and peanut stunt viruses. | Based on the results of agar gel double immunodiffusion tests with broad spectrum rabbit antisera and narrow spectrum mouse immune ascitic fluids and formalin-fixed purified viruses, a close relationship was established between 3 members of the Cucumovirus group namely Robinia mosaic virus (RoMV), clover blotch virus (... | 94,769 | [
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Detection and quantitation of Dermatophagoides antigens in house dust by immunochemical techniques. | Rabbit antibodies against D. pteronyssinus whole culture extract were rendered specific to mite antigens by immunoabsorption with extract of human dander. Using the absorbed antibodies, an extract of a mite culture gave rise to 15 peaks in crossed immunoelectrophoresis and to a titer of 512 in counter-immunoelectrophor... | 94,774 | [
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Effect of evisceration on the disposal of [14C] palmitate in the rat. | The utilization in vivo of [1-(14)C] palmitate was studied in hepatectomized-nephrectomized rats and their sham-operated controls. After i.v. injection of the tracer, the [14C] lipids in plasma disappeared more slowly in eviscerated animals than in their controls. More label reappeared in plasma as esterified fatty aci... | 94,827 | [
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Protein nutrition of Tenebrio molitor L. XX. Growth response of larvae to graded levels of amino acids. | Larvae of Tenebrio molitor L;, Gembloux strain, race F, having an average initial weight of 10 mg were reared for 4 weeks at 27 +/- 0.25 degrees C and 65 +/- 5% relative humidity on diets containing an amino-acid mixture resembling the composition of larval tissues; Each of 14 amino acids was tested individually at lev... | 94,831 | [
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Internalization of the amino terminal 1-78 sequence of the gamma chain of native fibrinogen and exposure associated with catabolism and plasmin cleavage. | Specific antibodies of the gamma 1--78 peptide of human fibrinogen were employed in binding assays and in equilibrium competitive inhibition assays to analyze the expression of gamma 1--78 antigenic determinants as an indication of the relative exposure of the gamma 1--78 sequence in the E domain of fibrinogen, high so... | 94,836 | [
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0.4999175,
0.06248498... |
[Effects of different concentrations of chloramphenicol on RNA synthesis in E. coli]. | In the presence of 2 microgram/ml chloramphenicol the rate of total RNA synthesis increases 1,6-fold, while that of rRNA synthesis--2,5--3,0-fold. Other ribosomal antibiotics, e.g. oxytetracycline, neomycin and puromycin, as well as chloramphenicol stimulate the synthesis of RNA while not causing a complete inhibition ... | 94,838 | [
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[Animal experiments on the induction of humoral antibodies by repeated implantations of dental gelatin and dried fibrin foam]. | An attempt was made to demonstrate humoral antibodies against porcine and bovine protein in the sera of guinea pigs following repeated subcutaneous implantation of Gelastypt, Gelfoam, and Fibrospum. Precipitated antibodies against porcine protein could not be demonstrated with the agar gel double diffusion test in the ... | 94,853 | [
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The effects of aminotriazole (ATZ) on the thyroid gland and the development of the White Leghorn chick. | White Leghorn chicks, injected i.p. (days 3 through 40) with 0.5 g/kg or 1.0 g/kg mean body weight of aminotriazole (ATZ), gained less weight than the control animals. In the 1.0 g/kg ATZ group in comparison to the 0.5 g/kg animals, the responses were of greater magnitude and for longer durations of time. In both exper... | 94,856 | [
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Clinical pharmacology of phlebotropic drugs. | Methods used in clinical and clinical pharmacological assessments of phlebotropic drugs are outlined. The knowledge of the pharmacokinetics and metabolism of phlebotropic drugs in human organism is far from complete as yet. Of objective methods proving haemodynamic effects of phlebotropic drugs, the authors have the be... | 94,865 | [
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Biochemical mechanism of platelet activation. Involvement of contractile proteins. | The present state of knowledge of the biochemical mechanism of platelet activation (adhesion, shape change, microspike formation, aggregation, release reaction, clot retraction) is presented under involvement of contractile proteins. The working hypothesis on the contractile mechanism of platelet activation is explaine... | 94,868 | [
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[The heterogeneity of streptokinases]. | Purified streptokinases of some strains of different types of Strep. pyrogenes (group A) as well as streptokinases of a strain of group C or group G streptococci, resp., were studied in regard of their heterogeneity. Differences of the streptokinases were found in their amino acid compositions and in isoelectric points... | 94,885 | [
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[Animal experimental studies on fibrinolysis with streptokinase]. | In contrast to rabbit blood plasma, in guinea pig and rat blood plasma activation of fibrinolysis by streptokinase is achieved after addition of human plasminogen or human plasma only. A simple experimental procedure for testing application forms of streptokinase in rats is described. Fibrinolysis in vivo is more effec... | 94,886 | [
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[Early Awelysin therapy in massive pulmonary embolism after hip alloarthroplasty]. | The fibrinolytic therapy of massive frest pneumatic embolism represents an ensured progress today. Until now it was only possible to report on those cases where the patients had survived at least two hours from the beginning of the acute event. Two cases are reported here where the patients were successfully treated in... | 94,891 | [
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Ability of enriched immune T cells to confer resistance in hamsters to infection with Treponema pertenue. | This investigation presents the first direct evidence that T cells are involved in resistance to challenge with Treponema pertenue. Enriched T cells from immune hamsters were obtained by sequential filtration through glass and nylon-wool columns. This procedure removed the majority of functional antibody-producing and ... | 94,906 | [
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... |
[Kinetic determination of alpha-amylase in serum and urine with an oligosaccharide as substrate--modification for a fully mechanized enzyme measuring device (author's transl)]. | The author reports a modification of the UV method UltraZyme Plus alpha-Amyl Harleco and the adaptation to the Eppendorf Enzymautomat 5010. alpha-amylase acts on an oligosaccharide mixture yielding maltose, which is hydrolysed by alpha-glucosidase. The liberated glucose is determined specifically by the hexokinase/gluc... | 94,928 | [
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... |
Tumor-associated antigenic differences between the primary and the descendant metastatic tumor cell populations. | The existence of antigenic differences between cell populations in the local growth of the 3LL tumor (L-3LL) and its lung metastases (M-3LL) was studied. Normal C57BL/6 spleen cells sensitized in vitro for 5 days against L-3LL monolayers lysed preferentially L-3LL targets but not M-3LL tumor cell targets. Conversely, a... | 94,933 | [
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[Our first results with cryotherapy on the prostate]. | It is reported on our first experiences with the cryotherapy in 15 patients with adenomas of the neck of the bladder and carcinoma of the prostate who all on account of high quantities of residual urine underwent a permannt catheterisation and in whom an open operation of Tur were contraindicated due to severe concurri... | 94,966 | [
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... |
The effect of cyclophosphamide on a secondary ocular immune response in rabbits. | Treatment of rabbits with immunosuppressive doses of cyclophosphamide during the primary response to intravitreally injected bovine gamma globulin did not prevent priming for a secondary response to the same antigen. High antibody titers were found in the aqueous humor and serum of most of the treated rabbits. Ocular t... | 94,972 | [
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... |
Genetic polymorphism and close linkage of two alpha 1-protease inhibitors in horse serum. | Two-dimensional electrophoretic analysis of horse serum proteins was done by a first-dimension separation in agarose gel (pH 5.4) followed by a second-dimension separation in horizontal polyacrylamide gel (pH 9.0). This method resulted in improved and reproducible separation of many alpha-globulins. Two groups of alpha... | 94,978 | [
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0.1... |
[Histochemical behavior of succinate dehydrogenase and lactate dehydrogenase as well as ribonucleic acid in the epithelium of lactic ducts and alveoli of cow udder]. | The activities of succinate dehydrogenase (SDR) and lactate dehydrogenase (LDH) as well as the ribonucleic acid levels in the epithelium of both the lactic ducts and alveoli of lactic glands were examined in heifers, close to full term, lactating cows, some of them with subclinical mastitis lesions, and udder biopsies ... | 94,987 | [
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[Carcinoma of papilla of Vater and its surgical treatment (author's transl)]. | Partial pancreato-duodenectomy is in our opinion the method of choice. Mortality rate 15%; 5-years survival rate 31.5%. The results obtained by resection of Vater's papilla are less favourable: the mean survival time comes only up to less than 50%. Palliative procedures should only be practiced in cases of incurability... | 95,074 | [
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... |
Effects of progesterone on the oestrogen-stimulated uterus: a comparative study of the mouse, guinea pig, rabbit and sheep. | To examine more closely the anti-oestrogenic action of progesterone (P), its effect on various parameters in the 17 beta-oestradiol (E2)-primed uterus of the mouse, guinea pig, rabbit and ewe was studied. Changes in uterine wet weight, rate of in vitro protein synthesis, protein : DNA and RNA : DNA ratios, peroxidase a... | 95,094 | [
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Development of metabolic shifts in structures of the spinal reflex arc in rats after space flight. | The stage of structures of the spinal reflex arc was studied by methods of quantitative cytochemistry in rats after orbital space flights lasting 19.5 and 22.5 days; the RNA and cytoplasmic protein content was determined in spinal motoneurons and sensory neurons of the spinal ganglia, the composition of soluble protein... | 95,099 | [
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0... |
Age-dependent changes in tolerizability with rabbit gamma-globulin in the Biozzi high and low-responder lines of mice. | The antibody response to rabbit gamma-globulin (RGG) of high-responder, but not of low-responder Biozzi mice decreased with age. Injection with aggregate-freed RGG reduced the response of high-responder but not of low-responder mice to subsequent injections with aggregated RGG. This reduction in the antibody response, ... | 95,106 | [
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Immunologically active zones in bovine growth hormone. | Antigenic determinant areas were detected in bovine growth hormone fragments 6--124 and 125--149, the former being predominant. Reduction and carboxymethylation of disulfide bridge 53--164 destroys the immunological reactivity of the area which is little affected by reduction and carbamoylmethylation. All the activity ... | 95,107 | [
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Actions of quinacrine on RNA and casein syntheses in mouse mammary gland explants. | Quinacrine at concentrations of 0.025 mM and greater significantly reduced or abolished the prolactin stimulation of RNA synthesis in mouse mammary gland explants. At concentrations of 0.01 mM or greater, the stimulatory action of prolactin on [3H]-leucine incorporation into a casein-rich protein fraction was also redu... | 95,126 | [
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Combination chemotherapy of malignant histiocytosis. | Three patients with malignant histiocytosis treated with combination chemotherapy are reported. Induction treatment included bleomycin, adriamycin, cyclophosphamide, vincristine and prednisone (BACOP). Complete response was obtained in one patient who is alive and well 32 months after diagnosis. A partial response was ... | 95,146 | [
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0.08372... |
Nucleic acids and protein changes in normal and pre-eclamptic placentae. | DNA and RNA assayed in the placentae of three groups of pregnant women: normal second trimester (16-28), normal third trimester (28 weeks up to term) and in preeclampsia. The protein level in the placentae of the three groups was also assayed. The proteins, DNA and RNA all decreased after 28 weeks and up to term in nor... | 95,149 | [
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Visualization of mitochondrial coupling factor F1(ATPase) by freeze-drying. | It is known that the negatively stained preparations of inner mitochondrial membrane display characteristic approximately 9 nm F1 (ATPase) knobs projecting from the matrix surface. Freeze-etch studies have reported the absence of such knobs from the "etched" surface of the inner mitochondrial membranes. We have demonst... | 95,168 | [
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... |
A theoretical model for adhesion between cells mediated by multivalent ligands. | A theoretical model is developed for cell-to-cell binding by bivalent ligands that can bind to mobile receptors on the cell surfaces. Monovalent inhibitors that can bind either to receptors or ligands are also included. For symmetrical ligands, that is, ligands in which both binding sites are the same, it is shown that... | 95,173 | [
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... |
Analysis of cellular DNA distributions. I. G2/G1 channel ratios. | In the influencent-flow cytophotometric measurement of cellular DNA content the DNA distributions usually have two peaks. The second peak, which corresponds to the 4C DNA content of G2 and M cells, is often positioned at lower values of DNA content than twice that of the 2C DNA peak which contains G1 cells. Computerize... | 95,178 | [
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... |
Heterogeneity, immunological comparison and concentration profiles of alpha-fetoproteins derived from late-gestational and early postnatal mouse tissue. | Four distinct alpha-fetoprotein (AFP) species were separated by ion-exchange chromatography of the approximately 70 000 dalton fraction of an extract of late-gestation fetal mice. Although chromatographicaly heterogeneous, antigenic differences among the AFP species resolved were not detected using classical double-dif... | 95,198 | [
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Pacing-induced alternate Wenckebach periods: incidence and clinical significance. | Alternate Wenckebach periods have been defined as episodes of 2:1 atrioventricular (AV) block in which conducted P waves exhibit progressive PR prolongation until two or three successively blocked P waves. Ocurrence of this phenomenon during atrial pacing has been established. Thirty-six patients were studied and right... | 95,224 | [
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... |
Aggression in humans correlates with cerebrospinal fluid amine metabolites. | Cerebrospinal fluid of the major central metabolites of serotonin (5HT), norepinephrine (NE), and dopamine (DA)--5-hydroxyindoleacetic acid (5HIAA), 3-methoxy-4-hydroxy=phenylglycol (MHPG), and homovanillic acid (HVA), respectively--were studied in a group of 26 age-similar military men with no history of major psychia... | 95,232 | [
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-0.06592952... |
An efficient procedure for serial nucleic acid hybridizations by titration analysis. | A simplified and efficient procedure has been developed for performing hybridization reactions and analyses of the percentage of hybridization on glass plates. This method is as accurate as conventional methods, while considerably reducing the time and costs to perform the hybridization in titration hybridization exper... | 95,241 | [
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Diagnostic implications of atrial vulnerability. | Extrastimulation in the atrial vulnerable zone may result in atrial fibrillation or flutter (AFF), especially with stimulation of multiple atrial sites. However, the clinical relevance of such vulnerability to AFF is unknown. Therefore, single twice-threshold extrastimuli were applied at three disparate right atrial si... | 95,283 | [
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Adrenergaically mediated ventricular fibrillation in probucol-treated dogs: roles of alpha and beta adrenergic receptors. | A high incidence of sudden death due to ventricular fibrillation (VF) has been observed in dogs under chronic treatment with probucol, a new hypocholesterolemic agent. The present study describes the cardiac electrophysiologic properties of probucol-treated dogs and characterizes the electrophysiological response of th... | 95,312 | [
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Gas chromatography and mass spectrometry of disaccharides from glycoproteins. | Partial acid hydrolysis and methanolysis released disaccharides and disaccharide methylglycosides from the glycoproteins, ovomucoid and porcine gastric mucin in amounts of 0.5--7 microgram disaccharide per mg of glycoprotein. These disaccharides were fractionated by gas chromatography as the trimethylsilyl (Me3Si) deri... | 95,343 | [
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-... |
Hearing thresholds with outer and inner hair cell loss. | Hearing impairment and related cochlear histopathologic changes were evaluated in experimental animals after treatment with aminoglycoside antibiotics or exposure to intense sound. In the course of treatment with kanamycin, neomycin, or dihydrostreptomycin, permanent hearing loss in monkeys and guinea pigs occurred fir... | 95,382 | [
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The fibrinolysin system in otitis media with effusion. | Middle ear effusions can cause the fibrinolytic dissolution of human fibrin clots. The data presented herein indicate that the highest level of fibrinolytic activity and general proteolytic activity is found in the serous effusions. The mucoid effusions show the lowest levels of fibrinolytic activity. The significance ... | 95,383 | [
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Preliminary quantification of immunological relationships among the transaldolases of the genus Bifidobacterium. | The immunological relatedness among the transaldolases (dihydroxyacetone transferase, E.C. 2.2.1.2) of twenty species of the genus Bifidobacterum has been tested by the microcomplement fixation method, using B. thermophilum (B. ruminale) RU326 (= ATCC 25866), B. cuniculi RA93 (= ATCC 27916) and B. 'minimum' (DNA homolo... | 95,386 | [
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0.251,
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Pathogenesis of proliferative neovascular retinopathies and the role of vitrectomy. A hypothesis. | Proliferative neovascular retinopathies may be caused by the release of a hypothetical vasoproliferative factor, but mechanical factors seem to self-perpetuate the disease as well. Contraction of proliferative tissue causes vitreous detachment and traction on the retina. Congestion of vascular fronds by traction furthe... | 95,405 | [
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-0.... |
Guinea-pig keratinocytes and melanocytes in tissue culture: scanning, transmission and high voltage electron microscope observations. | Keratinocytes and melanocytes cultured from guinea-pig epidermis were studied with scanning, transmission and high voltage electron microscopy to characterize the surface and internal morphology. Keratinocytes exhibited contact-inhibition and a range of surface structures consistent with cell-cycle dependent changes. S... | 95,456 | [
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[Effects of DDT and aldrin on swine cell line IB-RS-2]. | Swine cells IB-RS-2 were exposed to 0,1-100 microgram/ml medium of DDT and aldrin for 48 hours. The data obtained showed that both compounds decreased cell growth. This effect depends on the concentration and on the time of cell exposition to the insecticides. These compounds also decreased the levels of cellular prote... | 95,479 | [
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... |
[Chemotherapy of non-microcellular disseminated bronchial cancer (author's transl)]. | Fifty-one patients suffering from non-microcellular bronchial cancer with metastasis were divided at random into two groups: 33 patients received BACFON polychemotherapy, 18 patients did not receive chemotherapy. There was no global significant difference between the two groups (total mean survival time : 22 weeks with... | 95,488 | [
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-0.02124232,
0.1835902,
0.2319914,
0.4797588,
0.3480242,
0.1605323,
-0.075989... |
Na+ interacting with gramicidin D. A nuclear magnetic resonance study. | 23Na nuclei in a milk-white emulsion composed to nonionic surfactant and higher alcohol in saline were characterized by single values of T1 and T2 and a single Larmor frequency. In the presence of small amounts of gramicidin D (Dubos), the relaxations of 23Na were greatly accelerated, and the transverse relaxation was ... | 95,566 | [
-0.1049735,
-0.5483874,
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0.467067,
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0.2315643,
-0.06698742,
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0.2378396,
-0.04606711,
0.003340294,... |
[Determination of the ribonuclease activity of the duodenal contents of children as a test in the differential diagnosis of cystic fibrosis and pancreatic exocrine insufficiency]. | Ribonuclease activity was determined in the duodenal contents of healthy children, in children with cystic fibrosis and with pancreatic exocrine insufficiency. Assays were made at 7.0, in 0.05 M buffer without and with 0.35 M NaCl. The ratio of activity in 0.35 M NaCl to that in buffer alone was found to be 2.4 +/- 1.3... | 95,633 | [
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0.1752257,
0.1467538,
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0.06348096,
... |
Risks of delayed potentials in pacemaker patients prone to ventricular tachycardia. | Late potentials occurring after completion of the QRS complex have been observed in patients prone to ventricular tachycardia. They were recorded either during epicardial studies or in the catheterization laboratory. This paper describes such abnormal myocardial activity and discusses their potential effects on cardiac... | 95,639 | [
-0.1645195,
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0.1777549,
0.0004183854,
0.2836292,
0.1350643,
0.1776628,
... |
Increased survival of experimental skin flaps in rats following treatment with antiadrenergic drugs. | The effect upon the survival of skin flaps of several drugs which affect the adrenergic system was studied in rats. In control animals 41% of the skin flaps had survived seven days after the operation. Reserpine (1 mg/kg) injected intraperitoneally (i.p.) three days and one day before the flap operation increased the s... | 95,655 | [
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0.3056563,
0.09258243,
0.29583,
0.06798071,
-... |
[Indications for relief and palliative operations]. | Torkildsen and Spitz-Holter drainages and/or osteoclastic trepanation were performed on 29 patients suffering from a severe increase in intracranial pressure and/or a severely worsened general condition as a relieving intervention in order to permit a tumor operation later. The relieving measure enabled a tumor operati... | 95,657 | [
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0.006722269,
0.02611249,
0.1099927,
-0.1062803... |
Immunochemical comparison of human and goat haptoglobin and alpha 2-macroglobulin. | 1. A non-haptoglobin alpha 2-globulin was observed in the plasma of goats (Capra hircus) after inflammatory stresses. 2. This stress reaction protein exhibited an electrophoretic mobility and molecular weight similar to goat haptoglobin. 3. Complete immunological cross-reactivity was demonstrated between the goat prote... | 95,679 | [
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0.07029103,
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0.151951,
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0.1748581,
0.2905377,
-0.1833176,
0.2582907,
-0.2192373,
-0.21... |
Amylase activity, glycoprotein and electrolyte concentration in rat's submaxillary salivary gland during heat acclimation. | 1. Amylase activity, glycoproteins, Na and K concentrations were measured in submaxillary salivary gland of the rat during heat acclimation (34 degrees C). 2. Acclimation resulted in a decrease in glycoprotein concentration and amylase activity, whereas Na and K concentrations and the Na/K ratio increased. 3. It is sug... | 95,684 | [
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0.3125002,
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0.09753277,
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-0.4331306,
-0.03587371,
0.4037901,
-0.2069357,
0.202145,
-0.07048161,
-0.00777809... |
Selected enzyme activities in Mya arenaria hemolymph. | 1. The activities of lysozyme, acid and alkaline phosphatases, beta-glucuronidase, amylase, lipase, glutamate-oxalacetate transaminase, and glutamate-pyruvate transaminase in the whole hemolymph and 4000 g pellets and supernatants of Mya arenaria were determined. 2. All of these enzymes, except for amylase, occurred in... | 95,692 | [
0.1289202,
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0.2681434,
0.2625531,
0.3910152,
0.1228465,
-0.3236858,
0.28... |
Minute eye movement during sleep. | The minute eye movements of 4 sleeping subjects were studied with a piezo-electric strain-gauge transducer. The frequency and amplitude of ocular microtremor activity diminished during sleep. Activity increased after auditory stimulation and with the appearance of a K complex in the EEG. The ocular microtremor activity... | 95,706 | [
-0.07017149,
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-0.7751228,
0.1226717,
0.1329447,
-0.5172979,
0.3541064,
-0.3294088,
0.174... |
Minoxidil in resistant hypertension. | Minoxidil in combination with propranolol and diuretics controlled the blood-pressure in a group of hypertensive patients who were resistant to treatment with large doses of standard drugs. The main problem was fluid retention but subjective side-effects were fewer than in a comparable group on other drugs. | 95,728 | [
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0.17153,
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0.2250762,
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0.2398712,
0.1123511,
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-0.07856035,
0... |
Occurrence of M-proteins in the CSF of a child with prolonged meningococcal meningitis. | CSF of a 4-month-old boy with prolonged, meningococcal meningitis revealed oligoclonal immunoglobulin G about 10 weeks after hospital admission. These proteins persisted for at least 4 months. In contrast to this child, a further 10 infants and young children with bacterial meningitis, whose CSF was examined between 4 ... | 95,803 | [
-0.04788257,
0.03799051,
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0.449214,
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0.236743,
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0.1513488,
0.2574699,
-0.0585399,
0.0468821,
... |
[Vitamin E activity of some alpha-tocopherol derivatives and their effect on the ubiquinone level in rat liver in vitro]. | An addition of alpha-tocopherol (I) and its synthetic derivatives (alpha-tocopheryl quinone (II), its short-chained analog (III), alpha-tocopherol lactone (IV), and short-chained alpha-tocopheryl acetate (V)) to the homogenized liver of vitamin E deficient rats resulted in a significant increase of ubiquinone after 2 h... | 95,824 | [
-0.1517371,
0.1884291,
-0.1306119,
0.2024105,
0.2883488,
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0.1840014,
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0.3224448,
0.3226259,
0.1257615,
0.1602981,
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-0.009211507,
0.05880174,
0.3580959,
0.2848986,
0.3039807,
-0.01412522,
0... |
[Pigments produced by Bacillus subtilis var. niger 16k]. | Pigments produced by Bacillus subtilis var. niger 16k on tyrosine agar and histidine containing synthetic medium were isolated and identified. On the basis of a number of tests the pigments were classified as melanins. | 95,833 | [
0.04248134,
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0.08148539,
0.2070495,
0.004140315,
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0.003503507,
0.047095,
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0.3890843,
0.1618816,
0.1219563,
0.6828427,
0.08532498,
-0.1828998,... |
[Conditions for isolation of cholesterol oxidase from Actinomyces lavendulae mycelia]. | The isolation conditions, composition and certain properties of cholesterol oxidase from the mycelium Actinomyces lavendulae were studied. Selective extraction of the enzyme occurred upon the mycelium extraction by the Tween-80 containing buffer. The specific activity of cholesterol oxidase thus obtained exceeded seven... | 95,829 | [
-0.1006144,
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0.1334963,
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0.03093066,
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-1.025146,
0.1270764,
0.1549167,
0.4552984,
0.6020212,
0.2822971,
-0.06977343,
... |
[The histone hydrolase of the liver and kidneys in rats in postnatal ontogeny]. | It has been demonstrated that total homogenates and subcellular fractions of the liver and kidneys of rats exhibit proteolytic activity which specifically digests histone at pH 8.5. The activity of histone hydrolase undergoes age changes in all the subcellular fractions of the liver and kidneys, except the nuclear frac... | 95,849 | [
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-0.1992539,
0.3004633,
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0.2080087,
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0.2225914,
0.2133204,
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0.1917007,
0.1311748,
0.2295045,
0.3142964,
0.2988951,
-0.2222129,
-... |
Specificities of rabbit anti-human insulin receptor antibodies. | Human insulin receptors obtained from normal human placentae were highly purified by affinity chromatography and used to immunize rabbits. The immunological response was evaluated in order to reveal the presence of antibodies blocking the binding of insulin to monocytes of normal subjects. Since no blocking activity wa... | 95,885 | [
0.2660435,
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0.03106083,
0.2077432,
0.1035289,
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0.2110341,
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0.08891439,
0.1324247,
0.1329889,
-0.07846013,... |
[The oxygen affinity of hemoglobin in the reindeer Rangifer tarandus before and after labor]. | It has been demonstrated that the affinity of hemoglobin to oxygen in the reindeer Rangifer tarandus decreases with ageing. The value of P50 for hemoglobin of 2-3 month foetuses is equal to 22.0 +/- 0.8 mm Hg, newborn animals--to 24.5 +/- 0.5 and adult ones--to 28.0 +/- 0.5 mm Hg. After dialysis, these values are equal... | 95,887 | [
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0.3134484,
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0.2177269,
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0.1127944,
0.3153991,
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... |
[Precipitating immunoenzyme revealed tests on cellulose acetate. Use of ELIEDA (enzyme-linked-immuno-electro-diffusion assay) and ELIDEPA (enzyme-linked-immuno-double-electrophoresis-assay) in parasitology]. | Precipitating tests carried out on cellulose acetate membrane were revealed by treating the immune complexes with enzyme linked anti-immunoglobulin antibodies. We insist on the importance of ELIEDA (enzyme-linked-immuno-electro-diffusion-assay) and ELIDEPA (enzyme-linked-immuno-double-electro-phoresis-assay) for the st... | 95,891 | [
-0.04508975,
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0.1340107,
-0.04267661,
0.1717589,
0.4246082,
0.114281,
-0.1506294,
... |
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