title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Spectral transmittance of UV-blocking soft contact lenses: a comparative study. | Three major parts of sunlight consist of visible, ultraviolet and infrared radiation. Exposure to ultraviolet radiation (UVR) can result in a spectrum of skin and ocular diseases. UV-blocking contact lenses help provide protection against harmful UV radiation. We studied the ultraviolet and visible light rays transmiss... | 25,129,536 | [
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Gonadoblastoma and selected other aspects of gonadal pathology in young patients with disorders of sex development. | Some patients with disorders of sex development (DSDs), previously known as intersex disorders, have abnormal gonadal development and an increased risk of germ cell tumors. Because of their relative rarity, however, many pathologists are unfamiliar with the morphological findings in the gonads of DSD patients and their... | 25,129,544 | [
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Pathogenic vibrios in environmental, seafood and clinical sources in Germany. | Bacteria of the family Vibrionaceae naturally occur in marine and estuarine environments. Only few species of Vibrionaceae are associated with human cases of gastroenteritis, ear and wound infections, caused by ingestion of seafood or contact with Vibrio containing water. Increasing consumption of seafood (fish, fisher... | 25,129,553 | [
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A motion-compensated image filter for low-dose fluoroscopy in a real-time tumor-tracking radiotherapy system. | In the real-time tumor-tracking radiotherapy system, a surrogate fiducial marker inserted in or near the tumor is detected by fluoroscopy to realize respiratory-gated radiotherapy. The imaging dose caused by fluoroscopy should be minimized. In this work, an image processing technique is proposed for tracing a moving ma... | 25,129,556 | [
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Treatment of PTSD and Chronic Daily Headache. | Posttraumatic stress disorder (PTSD) is often comorbid with chronic migraine (CM) and chronic tension-type headache (CTTH). Trauma-focused cognitive behavioral psychotherapies, selective serotonin reuptake inhibitors (SSRIs), and venlafaxine have demonstrated efficacy in the treatment of PTSD. Amitriptyline, topiramate... | 25,129,572 | [
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Are the leukocyte telomere length attrition and telomerase activity alteration potential predictor biomarkers for sporadic TAA in aged individuals? | A large variability in occurrence, complications, and age/gender manifestations characterizes individual susceptibility of sporadic thoracic aortic aneurysms (TAA), even in subjects with the same risk factor profiles. The reasons are poorly understood. On the other hand, TAA pathophysiology mechanisms remain unclear th... | 25,129,574 | [
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Experiences with capnography in acute care settings: a mixed-methods analysis of clinical staff. | Although capnography is being incorporated into clinical guidelines, it is not used to its full potential. We investigated reasons for limited implementation of capnography in acute care areas and explored facilitators and barriers to its implementation. A purposeful sample of physicians and nurses in emergency departm... | 25,129,575 | [
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Management of mitral regurgitation in Marfan syndrome: Outcomes of valve repair versus replacement and comparison with myxomatous mitral valve disease. | The study objective was to evaluate patients with Marfan syndrome and mitral valve regurgitation undergoing valve repair or replacement and to compare them with patients undergoing repair for myxomatous mitral valve disease. We reviewed the medical records of consecutive patients with Marfan syndrome treated surgically... | 25,129,593 | [
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Developmental changes in guard cell wall structure and pectin composition in the moss Funaria: implications for function and evolution of stomata. | In seed plants, the ability of guard cell walls to move is imparted by pectins. Arabinan rhamnogalacturonan I (RG1) pectins confer flexibility while unesterified homogalacturonan (HG) pectins impart rigidity. Recognized as the first extant plants with stomata, mosses are key to understanding guard cell function and evo... | 25,129,633 | [
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Quantification of cocaine and metabolites in exhaled breath by liquid chromatography-high-resolution mass spectrometry following controlled administration of intravenous cocaine. | Breath has been investigated as an alternative matrix for detecting recent cocaine intake; however, there are no controlled cocaine administration studies that investigated the drug's disposition into breath. Breath was collected from 10 healthy adult cocaine users by asking them to breathe into a SensAbues device for ... | 25,129,634 | [
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Trends in analyzing emerging drugs of abuse--from seized samples to body samples. | This article summarizes the current status of and new trends of analytical approaches in the field of forensic/clinical toxicology for analyzing emerging drugs of abuse. Instruments and devices used for compound identification will be presented as well as types of biosample used to check for drug intake. Finally, a new... | 25,129,635 | [
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Diminished reliability of tryptase as risk indicator of mastocytosis in older overweight subjects. | Currently, measurement of serum tryptase level is the most commonly used test to estimate the need for bone marrow biopsy in patients suspected to have indolent systemic mastocytosis (ISM). Yet tryptase levels do not solely reflect the mast cell load and can be elevated by overweight, older age, and impaired renal func... | 25,129,675 | [
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Targeted sequencing by proximity ligation for comprehensive variant detection and local haplotyping. | Despite developments in targeted gene sequencing and whole-genome analysis techniques, the robust detection of all genetic variation, including structural variants, in and around genes of interest and in an allele-specific manner remains a challenge. Here we present targeted locus amplification (TLA), a strategy to sel... | 25,129,690 | [
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A simple and effective method to synthesize fluorescent nanoparticles using tryptophan and light and their lethal effect against bacteria. | A simple, environmentally friendly and cost-effective method was used to synthesize silver nanoparticles using tryptophan and light. To prepare the nanoparticles, the following components were used: deionized water, silver nitrate, light and tryptophan. The effects of the tryptophan concentration and light exposure tim... | 25,129,701 | [
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High tibial osteotomy. | High tibial osteotomy (HTO) is a widely accepted and performed procedure to treat medial knee arthrosis. The aim of this review is to evaluate the different surgical options in medial knee arthrosis, focusing on indications, patient's selection, long-term follow-up and survival analysis of HTO. Comparison and pooling o... | 25,129,702 | [
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The reliability of the anterior pelvic plane for computer navigated acetabular component placement during total hip arthroplasty: prospective study with the EOS imaging system. | Computer navigated total hip arthroplasty is mostly based on the use of the anterior pelvic plane (APP) as a reference. EOS is a new imaging system that provides three-dimensional analysis of the pelvis in a functional position with a low dose of radiation. The aim of this study was to evaluate the reliability of the A... | 25,129,705 | [
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Physicochemical characteristics of polysaccharide conjugates prepared from fresh tea leaves and their improving impaired glucose tolerance. | Hot-water extracts were prepared from fresh tea leaves and fractionated by DEAE-cellulose DE-52 column chromatography to yield one unexplored polysaccharide-conjugate fraction TPC-L (tea polysaccharide conjugates). Chemical components, molecular weight and its distribution, water vapor sorption properties, zeta potenti... | 25,129,719 | [
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Immunomodulation of human macrophages and myeloid cells by 2-substituted (1-3)-β-D-glucan from P. parvulus 2.6. | β-glucans produced by eukaryotic cells and by microorganisms are known to modulate immune responses by affecting macrophage activation. Here, we have investigated the effect of purified 2-substituted (1-3)-β-D-glucan, produced by either Pediococcus parvulus 2.6 or Lactococcus lactis NZ9000[pNGTF], on the effector funct... | 25,129,723 | [
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Improvement of polyvinyl alcohol properties by adding nanocrystalline cellulose isolated from banana pseudostems. | Cellulose nanocrystals (CNCs) isolated from banana pseudostems fibers (BPF) of the Pacovan variety were used as fillers in a polyvinyl alcohol (PVOH) matrix to yield a nanocomposite. The fibers from the external fractions of the BPF were alkaline bleached and hydrolyzed under acidic conditions (H2SO4 62% w/w, 70 min, 4... | 25,129,731 | [
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Electrosprayed inulin microparticles for microbiota triggered targeting of colon. | Inulin, a naturally occurring polysaccharide, was acetylated to make it processable by electrospraying, a facile and single step method for microparticle fabrication. Electrospraying process parameters were optimized for fabrication of spherical and monodisperse indomethacin (IDM) loaded inulin acetate (INA) microparti... | 25,129,739 | [
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Alginate based hybrid copolymer hydrogels--influence of pore morphology on cell-material interaction. | Alginate based hybrid copolymer hydrogels with unidirectional pore morphology were prepared to achieve synergistic biological performance for cardiac tissue engineering applications. Alginate based hybrid copolymer (ALGP) were prepared using alginate and poly(propylene fumarate) (HT-PPF) units. Different hybrid bimodal... | 25,129,740 | [
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Viscoelastic behavior of maize kernel studied by dynamic mechanical analyzer. | The creep recovery, stress relaxation, temperature-dependence and their frequency-dependence of maize kernel were determined within a moisture content range of 11.9% to 25.9% (w/w) by using a dynamic mechanical analyzer. The 4-element Burgers model was found to adequately represent the creep behavior of the maize seeds... | 25,129,754 | [
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Characterization of glucomannan from Amorphophallus oncophyllus and its prebiotic activity in vivo. | Porang (Amorphophallus oncophyllus) is local perennial plant rich in glucomannan. The aim of this study was to extract and characterize glucomannan from porang tuber and to evaluate its potency as prebiotic in vivo. The research consisted of the following steps, i.e. extraction of glucomannan, evaluation of its physico... | 25,129,770 | [
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Green synthesis of silver and gold nanoparticles employing levan, a biopolymer from Acetobacter xylinum NCIM 2526, as a reducing agent and capping agent. | With a vision of finding greener materials to synthesize nanoparticles, we report the production and isolation of levan, a polysaccharide with repeating units of fructose, from Acetobacter xylinum NCIM2526. The isolated levan were characterized using potassium ferricyanide reducing power assay, Fourier transform infra-... | 25,129,779 | [
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Influence of feeding regimens on rat gut fluids and colonic metabolism of diclofenac-β-cyclodextrin. | Feeding states may affect the performance of colonic prodrugs. The aim is to investigate the influence of feeding regimen in Wistar rats on: (i) distribution and pH contents along the gut and (ii) metabolism of two colonic prodrugs, diclofenac-β-cyclodextrin and a commercially available control, sulfasalazine, within t... | 25,129,806 | [
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Magnetic resonance perfusion and diffusion imaging characteristics of transient bone marrow edema, avascular necrosis and subchondral insufficiency fractures of the proximal femur. | To evaluate magnetic resonance (MR) perfusion and diffusion imaging characteristics in patients with transient bone marrow edema (TBME), avascular necrosis (AVN), or subchondral insufficiency fractures (SIF) of the proximal femur. 29 patients with painful hip and bone marrow edema pattern of the proximal femur on non-c... | 25,129,825 | [
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Remarkable diversity of tick or mammalian-associated Borreliae in the metropolitan San Francisco Bay Area, California. | The diversity of Lyme disease (LD) and relapsing fever (RF)-group spirochetes in the metropolitan San Francisco Bay area in northern California is poorly understood. We tested Ixodes pacificus, I. spinipalpis, and small mammals for presence of borreliae in Alameda County in the eastern portion of San Francisco Bay betw... | 25,129,859 | [
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Gait and lower extremity kinematic analysis as an outcome measure after femoroacetabular impingement surgery. | Lower extremity and pelvis kinematics have been shown to be abnormal in patients with femoroacetabular impingement (FAI). We conducted this systematic review to evaluate the current status of gait and lower extremity kinematics as an outcome measure in patients treated surgically for FAI. We searched the Embase, Medlin... | 25,129,866 | [
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0.02013939,
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0.02330746,
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The effects of family-friend visits on anxiety, physiological indices and well-being of MI patients admitted to a coronary care unit. | To investigate the effect of family-friend visits on anxiety, physiological indices and well-being of patients with acute myocardial infarction. A checklist was used to gather socio-demographic data and physiologic indices including blood pressure, heart rate, respiratory rate, and arterial oxygen saturation. The short... | 25,129,882 | [
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Absence of a simple code: how transcription factors read the genome. | Transcription factors (TFs) influence cell fate by interpreting the regulatory DNA within a genome. TFs recognize DNA in a specific manner; the mechanisms underlying this specificity have been identified for many TFs based on 3D structures of protein-DNA complexes. More recently, structural views have been complemented... | 25,129,887 | [
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0.08777522,
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[Effects of drought stress on growth and water use efficiency of two medicinal plants]. | Growth characteristics, stable carbon isotope discrimination (Delta13C), water use efficiency (WUE), and their correlation of Cassia obtusifolia and Isatis indigotica were measured at three soil water levels, i. e., 30%, 50% and 75% of field water holding capacity (FWHC), and at three growth stages. The growth indices ... | 25,129,928 | [
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... |
[Effects of inoculating plant growth-promoting rhizobacteria on the biological characteristics of walnut (Juglans regia) rhizosphere soil under drought condition]. | Effects of four plant growth-promoting rhizobacteria (PGPR) , namely Pseudomonas sp. YT3, Bacillus subtilis DZ1, B. cereus L90 and B. fusiformis L13 on the biological characteristics of walnut (Juglans regia) rhizosphere soil under drought stress were investigated. Results showed that drought stress had little effect o... | 25,129,951 | [
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[Analysis of TEOAE and AABR hearing screening and follow-up in NICU]. | To study the results of TEOAE and AABR hearing screening and follow-up in NICU. Total 574 cases in NICU were included in this study, all cases received both TEOAE and AABR hearing screening while admission and rescreening when one-month-old. The cases that were abnormal on either test in rescreening were asked to retur... | 25,129,970 | [
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... |
[Comparison of application of several psychophysical olfactory test methods in clinic]. | To compare the consistency of four olfactory psychophysical test methods. Twenty out-patients were done with olfactory psychophysical test and the results were analyzed. The four olfactory psychophysical test methods include simple test method, UPSIT, Sniffin Sticks test and the T&T olfactometer test. The consisten... | 25,129,973 | [
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0.04180421,
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0.1788349... |
[Effect of ambroxol on biofilm of Haemophilus influenzae and bactericidal action]. | To establish a biofilm model of Haemophilus influenzae and observe the effect of ambroxol on biofilm of Haemophilus influenzae and bactericidal action. Thirty strains of Haemophilus influenzae were isolated from adenoids of children with adenoidal hypertrophy. Two strains which could build stronger biofilms was selecte... | 25,129,975 | [
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... |
Glucocorticoids activate cardiac mineralocorticoid receptors in adrenalectomized Dahl salt-sensitive rats. | We previously showed that selective mineralocorticoid receptor (MR) blockade by eplerenone is cardioprotective in Dahl salt-sensitive (DS) rats. To clarify the consequences of glucocorticoid-mediated MR activation in these animals, we investigated the effects of exogenous corticosterone on blood pressure as well as car... | 25,129,992 | [
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Factors associated with early postpartum maternity blues and depression tendency among Japanese mothers with full-term healthy infants. | Maternity blues and postpartum depression are common mental health problems during the early postpartum period. However, few studies have examined the factors associated with maternity blues and postpartum depression in healthy mothers with spontaneous births of healthy full-term infants. This study aimed to determine ... | 25,129,999 | [
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Gamma knife radiosurgery of brain metastasis from malignant pleural mesothelioma--report of three cases with autopsy study in a case. | The median survival time of malignant pleural mesothelioma (MPM) has been 9 months. Given the short survival, there have been only few cases in which brain metastases have been diagnosed and treated before death. Three cases of brain metastases treated by gamma knife radiosurgery (GKR) are reported. Case I showed a met... | 25,130,005 | [
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0.3252559,
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0.09057798,
0.4530122,
-0.1881... |
Hazard analysis of Arid and semi-Arid (ASAL) regions of Kenya. | This paper describes a situationanalysis on hazards in the Arid and semi-Arid lands of Kenya. The leading hazards affecting the Arid and semi-arid lands are mainly natural and include among others drought, floods, and landslides. Other hazards of importance were found to be war and conflict, HIV/AIDS and fires. Over 80... | 25,130,021 | [
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0.2249716,
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0.4878658,
-0.1189... |
The kallikrein-kinin system in diabetic retinopathy. | Diabetic retinopathy (DR) is a major microvascular complication associated with type 1 and type 2 diabetes mellitus, which can lead to visual impairment and blindness. Current treatment strategies for DR are mostly limited to laser therapies, steroids, and anti-VEGF agents, which are often associated with unwanted side... | 25,130,041 | [
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0.3986883,
0.001060614,
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0.5289585,
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Management of children with possible appendicitis: a survey of emergency physicians in Australia and New Zealand. | To describe current practice in managing children with possible acute appendicitis in EDs in Australia and New Zealand as the basis for a clinical practice guideline (CPG). An anonymous survey was distributed to consultant emergency physicians working at PREDICT (Paediatric Research in Emergency Departments Internation... | 25,130,047 | [
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A half-sandwich organometallic single-ion magnet with hexamethylbenzene coordinated to the Dy(III) ion. | A half-sandwich organolanthanide complex, [(C6Me6)Dy(AlCl4)3], in which Dy(III) is coordinated with a π-bonded arene was synthesized and magnetically characterized. This complex displays slow magnetic relaxation and a hysteresis loop associated with single-ion magnet behavior. The orientation of the magnetic anisotropy... | 25,130,080 | [
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0.2532005,
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Single-walled carbon nanotube-based polymer monoliths for the enantioselective nano-liquid chromatographic separation of racemic pharmaceuticals. | Single-walled carbon nanotubes were encapsulated into different polymer-based monolithic backbones. The polymer monoliths were prepared via the copolymerization of 20% monomers, glycidyl methacrylate, 20% ethylene glycol dimethacrylate and 60% porogens (36% 1-propanol, 18% 1,4-butanediol) or 16.4% monomers (16% butyl m... | 25,130,087 | [
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... |
A novel approach to the quantitative detection of anabolic steroids in bovine muscle tissue by means of a hybrid quadrupole time-of-flight-mass spectrometry instrument. | In recent years, the analysis of veterinary drugs and growth-promoting agents has shifted from target-oriented procedures, mainly based on liquid chromatography coupled to triple-quadrupole mass spectrometry (LC-QqQ-MS), towards accurate mass full scan MS (such as Time-of-Flight (ToF) and Fourier Transform (FT)-MS). In... | 25,130,093 | [
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Marked elevation of serum hyaluronan levels in collagenofibrotic glomerulopathy. | Collagenofibrotic glomerulopathy is a rare glomerular disease characterized by the massive deposition of type III collagen in mesangial and subendothelial spaces. We observed markedly increased serum hyaluronan levels in patients with collagenofibrotic glomerulopathy; levels in three patients were more than 1,000-times... | 25,130,114 | [
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Wandering pneumonia caused by dabigatran. | We herein describe the case of a 74-year-old man who experienced pulmonary consolidation and chest pain following administration of dabigatran, a novel oral anticoagulant. The consolidation settled spontaneously in another lung area, a condition sometimes referred to as "wandering pneumonia." Although we did not find s... | 25,130,119 | [
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... |
Crystalglobulinemia with fulminant course with cylinder-like bodies on peripheral blood smear. | A 63-year-old woman presented to our hospital with fever, purpura and pain in both legs and died 4 days after admission. Her blood smear and skin biopsy showed cylinder-like bodies (20×120 μm). She was diagnosed to have monoclonal gammopathy (IgG, lambda type). An autopsy revealed cylinder-like bodies in the vasculatur... | 25,130,123 | [
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0.3... |
Bortezomib-induced posterior reversible encephalopathy syndrome: clinical and imaging features. | Posterior reversible encephalopathy syndrome (PRES) is a rare and potentially harmful complication in patients receiving targeted chemotherapy. We herein present a case of PRES that occurred after 33 days of high-dose bortezomib treatment and propose both overwhelmed cerebral autoregulation and toxin-mediated blood-bra... | 25,130,124 | [
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0.3302472,
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Prevotella brain abscesses and stroke following dental extraction in a young patient: a case report and review of the literature. | A brain abscess is a life-threatening infection. There are few reports describing Prevotella bacteremia with middle cerebral artery (MCA) occlusion and brain abscess following dental extraction in the literature. We herein describe a 32-year-old healthy man who experienced headache after tooth extraction. He was not co... | 25,130,130 | [
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0.0181481,
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0.07860803,
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Barriers and facilitators to yoga use in a population of individuals with self-reported chronic low back pain: a qualitative approach. | Yoga has been found to be efficacious in treating chronic low back pain, yet biomedical treatments are most commonly used for pain. Promoting yoga as part of integrative care would reduce exclusive reliance on high-cost, higher-risk biomedical treatments. Attitudes toward yoga play a role in consideration of it as a tr... | 25,130,139 | [
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0.07777647,
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... |
Immune gene expressions in grouper larvae (Epinephelus coioides) induced by bath and oral vaccinations with inactivated betanodavirus. | Nervous necrosis virus (NNV) has caused mass mortality in many mariculture fish species. Bath vaccination of inactivated NNV and oral immunization of recombinant NNV coat protein are reported to protect grouper larvae against NNV infection. However, the information of immune gene expression in grouper larvae (Epinephel... | 25,130,145 | [
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0.07451072,
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Comparative nutritional and chemical phenome of Clostridium difficile isolates determined using phenotype microarrays. | Clostridium difficile infection (CDI) is the leading cause of infectious diarrhea in North America and Europe. The risk of CDI increases significantly in the case where antimicrobial treatment reduces the number of competing bacteria in the gut, thus leading to the increased availability of nutrients and loss of coloni... | 25,130,165 | [
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... |
Enriched CD44(+)/CD24(-) population drives the aggressive phenotypes presented in triple-negative breast cancer (TNBC). | The mechanism underlying the aggressive behaviors of triple negative breast cancer (TNBC) is not well characterized yet. The association between cancer stem cell (CSC) population and the aggressive behaviors of TNBC has not been established. We found the CD44(+)/CD24(-) cell population was enriched in TNBC tissues and ... | 25,130,168 | [
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0... |
Bergamottin, a natural furanocoumarin obtained from grapefruit juice induces chemosensitization and apoptosis through the inhibition of STAT3 signaling pathway in tumor cells. | Persistent activation of signal transducers and activator of transcription 3 (STAT3) has been closely related to growth, survival, proliferation, metastasis, and angiogenesis of various cancer cells, and thus its inhibition can be considered a potential therapeutic strategy. In this study, we investigated the role of b... | 25,130,169 | [
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Hypoxia inducible factor (HIF)-1α directly activates leptin receptor (Ob-R) in pancreatic cancer cells. | The aim of this study is to investigate the regulatory mechanism of leptin receptors (Ob-R) in pancreatic cancer. We found that the over-expression of hypoxia inducible factor (HIF-1)α and hypoxia up-regulated the expression of Ob-R in pancreatic cancer cells. When HIF-1α gene was silenced in vitro, the expression of O... | 25,130,171 | [
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Family meals and disordered eating in adolescents: are the benefits the same for everyone? | To examine the association between family meals and disordered eating behaviors within a diverse sample of adolescents and further investigate whether family-level variables moderate this association. Data from adolescents (EAT 2010: Eating and Activity in Teens) and their parents (Project F-EAT: Families and Eating an... | 25,130,186 | [
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Assessing the effectiveness of the 'Incredible Years(®) parent training' to parents of young children with ADHD symptoms - a preliminary report. | This study examined the effectiveness of an evidence-based parent training program in a real-world Scandinavian setting. Parents of 36 young children with or at risk of Attention Deficit Hyperactive Disorder (ADHD) self-referred to participate in the Incredible Years(®) Parent Training Program (IYPT) through a Danish e... | 25,130,208 | [
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Family gym: a model to promote physical activity for families with young children. | This report describes Family Gym, a family-centered model that (1) provides free access to physical activity for low-income families in the inner city; (2) targets young children (3-8 years) and their families; (3) engages families together in physical activity; and (4) stimulates social interaction among families. | 25,130,227 | [
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Do our patients have enough to eat?: Food insecurity among urban low-income cancer patients. | This study assessed the prevalence and predictors of food insecurity among a cohort of underserved oncology patients at New York City cancer clinics. A demographic survey and the U.S. Household Food Security Survey Module were administered. A multivariate General Linear Model Analysis of Covariance was used to evaluate... | 25,130,231 | [
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Case of radioactive iodine exposure during pregnancy. | A 43-year-old woman (gravida 0, para 0) was diagnosed with thyroid carcinoma and had been receiving radioactive iodine for remnant ablation. Eventually, her pregnant status became apparent; during radiation, she was at 5 gestational weeks. She decided to continue the pregnancy and delivered a boy of 2362 g at 37 gestat... | 25,130,255 | [
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Use of porcine luteinizing hormone at oestrous onset in a protocol for fixed-time artificial insemination in gilts. | The aim of this study was to evaluate the effect of porcine luteinizing hormone (pLH) given at oestrous onset in gilts, by different routes and doses, on the interval between onset of oestrus and ovulation (IOEO) and reproductive performance using a single fixed-time artificial insemination (FTAI). A total of 153 gilts... | 25,130,264 | [
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Diagnosing and following adult patients with acute myeloid leukaemia in the genomic age. | The diagnosis and follow-up process of adult patients with acute myeloid leukaemia (AML) is challenging to clinicians and laboratory staff alike. While several sets of recommendations have been published over the years, the development of high throughput screening and characterization for both genetic and epigenetic ev... | 25,130,287 | [
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Rats' choices with token stimuli in concurrent variable-interval schedules. | Four rats responded on concurrent variable-interval schedules that delivered token stimuli (stimulus lights arranged vertically above each of two side levers). During exchange periods, each token could be exchanged for one food pellet by responding on a center lever, with one response required for each pellet delivery.... | 25,130,299 | [
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Cisplatin-induced testicular toxicity in rats: the protective effect of arjunolic acid. | In the present study, the effect of arjunolic acid on testicular damage induced by intraperitoneal injection of rats with 7 mg/kg cisplatin was studied. Cisplatin induced a significant reduction in testicular weights, plasma testosterone, and testicular reduced glutathione levels in addition to a significant elevation ... | 25,130,312 | [
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Obesity. | This narrative symposium was inspired by the American Medical Associations (AMA) decision to label obesity a disease. How do people who have been classified as obese feel this decision impacts on their lives? Personal narrative authors offer their experiences with obesity and healthcare. The symposium also hosts five c... | 25,130,337 | [
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Edge effects in the primate community of the biological dynamics of Forest Fragments Project, Amazonas, Brazil. | While much is known about abiotic and vegetative edge effects in tropical forests, considerably less is known about the impact of forest edges on large mammals. In this study, we examine edge effects in a primate community to determine: 1) the distance from the edge over which edge effects in primate density are detect... | 25,130,367 | [
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miR-338-3p is over-expressed in blood, CFS, serum and spinal cord from sporadic amyotrophic lateral sclerosis patients. | Amyotrophic lateral sclerosis (ALS) is a progressive and seriously disabling adult-onset neurological disease. Ninety percent of ALS patients are sporadic cases (sALS) with no clear genetic linkage. Accumulating evidence indicates that various microRNAs (miRNAs), expressed in a spatially and temporally controlled manne... | 25,130,371 | [
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Efficiency of electronically monitored amblyopia treatment between 5 and 16 years of age: new insight into declining susceptibility of the visual system. | The notion of a limited, early period of plasticity of the visual system has been challenged by more recent research demonstrating functional enhancement even into adulthood. In amblyopia ("lazy eye") it is still unclear to what extent the reduced effect of treatment after early childhood is due to declining plasticity... | 25,130,409 | [
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Ultrathin core-sheath fibers for liposome stabilization. | Ultrathin core-sheath fibers with small unilamellar vesicles (SUVs) in the core were prepared by coaxial electrospinning. SUVs/sodium hyaluranate (HA-Na)/water and polyvinylpyrrolidone (PVP)/ethanol solutions were used as core and sheath fluid in electrospinning, respectively. The ultrathin fibers were characterized by... | 25,130,418 | [
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Delphinid systematics and biogeography with a focus on the current genus Lagenorhynchus: multiple pathways for antitropical and trans-oceanic radiation. | The six species currently classified within the genus Lagenorhynchus exhibit a pattern of antitropical distribution common among marine taxa. In spite of their morphological similarities they are now considered an artificial grouping, and include both recent and the oldest representatives of the Delphinidae radiation. ... | 25,130,419 | [
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IFN-γ CA microsatellite polymorphism is associated with susceptibility to respiratory syncytial virus Infection and severity. | IFN-γ, an essential cytokine in the viral cell-mediated immune response, has been associated with the pathogenesis of respiratory syncytial virus (RSV) bronchiolitis and to the severity of the infection. The aim of this study was to investigate whether IFN-γ CA microsatellite (rs3138557) polymorphism was associated wit... | 25,130,433 | [
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Improved tracking performance of Lagrangian block-matching methodologies using block expansion in the time domain: in silico, phantom and in vivo evaluations. | The aim of this study was to evaluate tracking performance when an extra reference block is added to a basic block-matching method, where the two reference blocks originate from two consecutive ultrasound frames. The use of an extra reference block was evaluated for two putative benefits: (i) an increase in tracking pe... | 25,130,445 | [
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Friends interventions in psychosis: a narrative review and call to action. | To highlight the importance of friendships to young people with psychosis, and the need for clinical interventions to help maintain peer relationships during illness. To structure a research agenda for developing evidence-based interventions with friends. An argument is developed through a narrative review of (i) the p... | 25,130,455 | [
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Correlates of adolescent and young adult sexual initiation patterns. | Identifying adolescent characteristics associated with different patterns of sexual initiation is critical to promoting healthy sexual development. Patterns of sexual initiation were examined among 12,378 respondents to Waves 1 (1994-1995) and 4 (2008) of the National Longitudinal Study of Adolescent Health. Multinomia... | 25,130,473 | [
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Validation of mechanical, electrical and thermal nociceptive stimulation methods in horses. | To validate a model for investigating the effects of analgesic drugs on mechanical, thermal and electrical stimulation testing. To investigate repeatability, sensitivity and specificity of nociceptive tests. Randomised experiment with 2 observers in 2 phases. Mechanical (M), thermal (TL) and electrical (E) stimuli were... | 25,130,475 | [
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A prognosis based classification of undifferentiated uterine sarcomas: identification of mitotic index, hormone receptors and YWHAE-FAM22 translocation status as predictors of survival. | Undifferentiated uterine sarcomas (UUS) are rare tumors with a heterologous biology and a poor prognosis. The goal of this study was to examine clinicopathology, biomarkers and YWHAE-FAM22 translocation status, in the prognosis of these tumors. Twenty-six cases of UUS were included. All original slides were rereviewed ... | 25,130,488 | [
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Comparison of therapeutic results from radiofrequency ablation and stereotactic body radiotherapy in solitary lung tumors measuring 5 cm or smaller. | This retrospective study was conducted to compare the clinical outcomes of radiofrequency ablation (RFA) with those of stereotactic body radiotherapy (SBRT) in patients with lung tumors. Local tumor progression, adverse events, and overall survival were compared in patients who underwent either RFA or SBRT for a single... | 25,130,494 | [
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Investigation of pediatric neck response and muscle activation in low-speed frontal impacts. | Pediatric necks present different responses and injury patterns compared with those of adults in motor vehicle crashes (MVCs). To evaluate the effect of different muscle modeling methodologies, three muscle models were developed and simulated under low-speed frontal impact conditions with an average peak acceleration o... | 25,130,495 | [
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Mesochanneled hierarchically porous aluminosiloxane aerogel microspheres as a stable support for pH-responsive controlled drug release. | The molecular-scale self-assembly of a 3D aluminosiloxane (Al-O-Si) hybrid gel network was successfully performed via the cocondensation of hydrolyzed alumina (AlOOH) and (3-aminopropyl)trimethoxysilane (APS). It was transformed into a microspherical aerogel framework of Al-O-Si containing mesochannels with tunable hie... | 25,130,541 | [
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Asymmetric synthesis of agrochemically attractive trifluoromethylated dihydroazoles and related compounds under organocatalysis. | The unique, partially saturated, fluorinated five-membered heterocyclic compounds, trifluoromethylated dihydroazoles, and their derivatives, have emerged as a new class of heterocycles with remarkable biological activities in the 21st century. Despite their small molecular structures, a single sterically demanding tetr... | 25,130,550 | [
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Sea surface temperature contributes to marine crocodylomorph evolution. | During the Mesozoic and Cenozoic, four distinct crocodylomorph lineages colonized the marine environment. They were conspicuously absent from high latitudes, which in the Mesozoic were occupied by warm-blooded ichthyosaurs and plesiosaurs. Despite a relatively well-constrained stratigraphic distribution, the varying di... | 25,130,564 | [
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JSAP1 and JLP are required for ARF6 localization to the midbody in cytokinesis. | The ADP-ribosylation factor 6 (ARF6) GTPase is important in cytokinesis and localizes to the midbody. However, the mechanism and regulation of ARF6's recruitment to the midbody are largely unknown. Here, we investigated the functions of two binding partners of active ARF6, c-Jun NH2 -terminal kinase (JNK)/stress-activa... | 25,130,574 | [
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Male patients with terminal renal failure exhibit low serum levels of antimüllerian hormone. | Male reproductive function is impaired during end-stage renal disease (ESRD). Disturbance of the hypothalamic-pituitary-gonadal axis, and therefore the regulation of sex hormones, is one of the major causes. Our focus was to include antimüllerian hormone (AMH) and inhibin B concentrations. Twenty male patients on hemod... | 25,130,586 | [
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Benzodithiophene based π-conjugated macrocycles: synthesis, morphology and electrochemical characterization. | A 7,8-didodecyloxybenzo[1,2-b:4,3-b']dithiophene (BdT-Dod) containing a macrocycle was synthesized from a thiophene capped BdT-Dod comonomer through a Ti(iv) mediated McMurry reaction and characterized by (1)H NMR, (13)C NMR and MALDI-TOF mass spectrometry. Additionally, the morphological characterization was performed... | 25,130,594 | [
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A nationwide population-based cohort study on tonsillectomy and subsequent cancer incidence. | Tonsillectomy is related to increased risk of certain types of cancer. This study evaluates the possible association between tonsillectomy and cancer in Taiwan. Data from the National Health Insurance system of Taiwan was used. A cohort study consisting of 997 patients with a new diagnosis of tonsillectomy from 2000 to... | 25,130,597 | [
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0.34... |
Nursing educators' perceptions about disaster preparedness and response in Istanbul and Miyazaki. | As healthcare professionals, nursing educators need to be prepared to manage and deliver care in what are often dangerous conditions. This research aims to determine and compare nursing educators' perceptions of disaster preparedness and response (DP&R) in Istanbul and Miyazaki. An 18 question descriptive questionn... | 25,130,598 | [
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Fabrication of ultralong hybrid microfibers from nanosheets of reduced graphene oxide and transition-metal dichalcogenides and their application as supercapacitors. | Two-dimensional materials have attracted increasing research interest owing to their unique electronic, physical, optical, and mechanical properties. We thus developed a general strategy for the fabrication of ultralong hybrid microfibers from a mixture of reduced graphene oxide and transition-metal dichalcogenides (TM... | 25,130,600 | [
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[Effect of the liquid milk nutritional supplement with enhanced content of whey protein on the nutritional status of the elderly]. | The aim of this study was to evaluate the effect of long-term administration of liquid nutritional supplement with increased amounts of whey protein and reduced amounts of lactose, produced in accordance with a new recipe "Nutrisen" on the elderly living in institutionalized care. The study was carried out from May to ... | 25,130,629 | [
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[Importance of lymphangiogenesis and ultrastructure of lymphatic capillaries in metastasis of malignant melanoma]. | Lymphangiogenesis - proliferation of lymphatic capillaries - in melanoma and in its vicinity plays an important role in metastatic process of malign melanoma cells in organism. Melanoma produces epidermal growth factor EGF which induces vascular endothelial growth factor VEGF-C and thereby starts lymphangiogenesis. It ... | 25,130,633 | [
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[What is new in heart failure with preserved ejection fraction within last five years?]. | Heart failure with preserved ejection fraction of left ventricle (heart failure with normal ejection fraction, HFPEF, HFNEF) is frequent disease with serious consequences. Incidence of HFPEF in population is still growing. The exact pathophysiological mechanism of HFPEF remain unclear .Recent evidence suggests a relati... | 25,130,634 | [
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[Specifics of diabetes mellitus in women]. | Approximately 4 % of female population suffers from diabetes. A permanent interaction between diabetes, its treatment and sex hormonal changes (childhood, puberty, reproduction, pregnancy, menopause) occurs in those women. This review article summarizes up to date published studies concerning reciprocal relationship be... | 25,130,635 | [
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[Education model at the Clinic of Internal Medicine of the Faculty Hospital Motol Prague - our experience with local education project for young physicians on postgraduate education]. | In 2004 the principal legislative changes were accepted in the field of postgraduate medical education in Czech Republic (law No. 95/2004 Code). Replacement of two-stage system of specialized education by its one- stage option has brought some problems and according to our opinion did not lead to clear improvement of p... | 25,130,637 | [
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0.22... |
The protective role of prosaposin and its receptors in the nervous system. | Prosaposin (also known as SGP-1) is an intriguing multifunctional protein that plays roles both intracellularly, as a regulator of lysosomal enzyme function, and extracellularly, as a secreted factor with neuroprotective and glioprotective effects. Following secretion, prosaposin can undergo endocytosis via an interact... | 25,130,661 | [
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Genetic variability in anthocyanin composition and nutritional properties of blue, purple, and red bread (Triticum aestivum L.) and durum (Triticum turgidum L. ssp. turgidum convar. durum) wheats. | Renewed interest in breeding for high anthocyanins in wheat (Triticum ssp.) is due to their antioxidant potential. A collection of different pigmented wheats was used to investigate the stability of anthocyanins over three crop years. The data show higher anthocyanins in blue-aleurone bread wheat (Triticum aestivum L.)... | 25,130,676 | [
0.05645866,
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0.065391,
0.2787324,
0.5101909,
-0.2271595,
-0.3033... |
Sequential gene silencing using wavelength-selective caged morpholino oligonucleotides. | Spectrally differentiated caged morpholino oligonucleotides (cMOs) and wavelength-selective illumination have been used to sequentially inactivate organismal gene function. The efficacy of these reverse-genetic chemical probes has been demonstrated in zebrafish embryos, and these reagents have been employed to examine ... | 25,130,695 | [
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The effects of the pharmaceutical carbamazepine on life history characteristics of flat-headed mayflies (Heptageniidae) and aquatic resource interactions. | Pharmaceutical pollutants are commonly detected in freshwater ecosystems around the world and have biological effects on aquatic organisms. However, current understanding of the influence this contaminant class has on freshwater communities and ecosystems is lacking. Recently the scientific community has called for res... | 25,130,701 | [
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Injurious tail biting in pigs: how can it be controlled in existing systems without tail docking? | Tail biting is a serious animal welfare and economic problem in pig production. Tail docking, which reduces but does not eliminate tail biting, remains widespread. However, in the EU tail docking may not be used routinely, and some 'alternative' forms of pig production and certain countries do not allow tail docking at... | 25,130,712 | [
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Canalicular network morphology is the major determinant of the spatial distribution of mass density in human bone tissue: evidence by means of synchrotron radiation phase-contrast nano-CT. | In bone remodeling, maturation of the newly formed osteonal tissue is associated with a rapid primary increase followed by a slower secondary increase of mineralization. This requires supply and precipitation of mineral into the bone matrix. Mineral delivery can occur only from the extracellular fluid via interfaces su... | 25,130,720 | [
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Genetic battle between Helicobacter pylori and humans. The mechanism underlying homologous recombination in bacteria, which can infect human cells. | Helicobacter pylori is a gram-negative pathogenic bacterium that colonises the human stomach. The chronic infection it causes results in peptic ulcers and gastric cancers. H. pylori can easily establish a chronic infection even if the immune system attacks this pathogen with oxidative stress agents and immunoglobulins.... | 25,130,723 | [
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Conformation-specific antibodies to target amyloid β oligomers and their application to immunotherapy for Alzheimer's disease. | Amyloid β-protein (Aβ) oligomers, intermediates of Aβ aggregation, cause cognitive impairment and synaptotoxicity in the pathogenesis of Alzheimer's disease (AD). Immunotherapy using anti-Aβ antibody is one of the most promising approaches for AD treatment. However, most clinical trials using conventional sequence-spec... | 25,130,729 | [
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0.2703757,
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0.03642575,
0.09056301,
0.3280564,
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... |
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