title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Activity profiles of elite wheelchair rugby players during competition. | To quantify the activity profiles of elite wheelchair rugby (WCR) players and establish classification-specific arbitrary speed zones. In addition, indicators of fatigue during full matches were explored. Seventy-five elite WCR players from 11 national teams were monitored using a radio-frequency-based, indoor tracking... | 25,202,822 | [
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The longitudinal association of the diurnal cortisol rhythm with internalizing and externalizing problems in pre-schoolers. The Generation R Study. | Studies investigating the association between diurnal cortisol rhythm and behavioural problems in young children have yielded inconsistent results. We tested the hypothesis that variations in diurnal cortisol rhythm in pre-schoolers are already related to problem behaviour early in life with a cross-sectional and longi... | 25,202,831 | [
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Predictors of airway hyperresponsiveness in elite athletes. | Elite athletes frequently experience asthma and airway hyperresponsiveness (AHR). We aimed to investigate predictors of airway pathophysiology in a group of unselected elite summer-sport athletes, training for the summer 2008 Olympic Games, including markers of airway inflammation, systemic inflammation, and training i... | 25,202,844 | [
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Attentional costs and failures in air traffic control notifications. | Large display screens are common in supervisory tasks, meaning that alerts are often perceived in peripheral vision. Five air traffic control notification designs were evaluated in their ability to capture attention during an ongoing supervisory task, as well as their impact on the primary task. A range of performance ... | 25,202,855 | [
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Reduced susceptibility to Fusarium head blight in Brachypodium distachyon through priming with the Fusarium mycotoxin deoxynivalenol. | The fungal cereal pathogen Fusarium graminearum produces deoxynivalenol (DON) during infection. The mycotoxin DON is associated with Fusarium head blight (FHB), a disease that can cause vast grain losses. Whilst investigating the suitability of Brachypodium distachyon as a model for spreading resistance to F. graminear... | 25,202,860 | [
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Type III secretion system. | The type III secretion system (T3SS) is a membrane-embedded nanomachine found in several Gram-negative bacteria. Upon contact between bacteria and host cells, the syringe-like T3SS (Figure 1) transfers proteins termed effectors from the bacterial cytosol to the cytoplasm or the plasma membrane of a single target cell. ... | 25,202,865 | [
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Evolution: sympatric speciation the eusocial way. | Sympatric speciation normally requires particular conditions of ecological niche differentiation. However, ant social parasites have been suspected to arise sympatrically, because (dis)loyalty to eusocial kin-structures induces disruptive selection for dispersal and inbreeding. A new study documents this process in unp... | 25,202,870 | [
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Nascent adhesions: from fluctuations to a hierarchical organization. | Integrins assemble a complex network of molecular interactions at cell-matrix adhesion sites. Fluorescence correlation microscopy has now shed light on the spatial, temporal and numerical distributions of protein complexes during assembly and stabilization of nascent adhesions. | 25,202,871 | [
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Neurogenetics: sex and the female brain. | Male flies put on a multimedia show during courtship involving dance, song, perfume and even vibrations; if a female likes it, she pauses to let him know. Recent studies shed new light on how development and experience contribute to neural mechanisms of female sexual receptivity. | 25,202,876 | [
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Epithelial homeostasis. | Epithelia form intelligent, dynamic barriers between the external environment and an organism's interior. Intercellular cadherin-based adhesions adapt and respond to mechanical forces and cell density, while tight junctions flexibly control diffusion both within the plasma membrane and between adjacent cells. Epithelia... | 25,202,877 | [
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Three-dimensional illumination procedure for photodynamic therapy of dermatology. | Light dosimetry is an important parameter that affects the efficacy of photodynamic therapy (PDT). However, the irregular morphologies of lesions complicate lesion segmentation and light irradiance adjustment. Therefore, this study developed an illumination demo system comprising a camera, a digital projector, and a co... | 25,202,901 | [
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Myelin Basic Protein and a Multiple Sclerosis-related MBP-peptide Bind to Oligonucleotides. | Aptamer ligands for myelin basic protein (MBP) were obtained using the systematic evolution of ligand by exponential enrichment (SELEX) method. Two clones were isolated from a pool of oligonucleotides and tested for MBP targeting. Using purified MBP, we demonstrated the binding activity of the aptamers and we also show... | 25,202,925 | [
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Scoliosis and chest cage deformity measures predicting impairments in pulmonary function: a cross-sectional study of 492 patients with scoliosis to improve the early identification of patients at risk. | This study examines the correlations between pulmonary function tests (PFTs) and radiographical measures of spinal deformities in patients with scoliosis. To define the parameters that enable more accurate predictions of restricted pulmonary function (PF) in patients with scoliosis. The early identification of patients... | 25,202,929 | [
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Thirty-Day Perioperative Outcomes in Spinal Fusion by Specialty Within the NSQIP Database. | Cross-sectional analysis of the American College of Surgeons' National Surgical Quality Improvement Program database between 2005 and 2011. To determine whether differences exist in 30-day rate of return to the operating room, mortality, and other perioperative outcomes for spinal fusion by specialty. Although both neu... | 25,202,939 | [
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[Diffusion weighted imaging of SCA3/MJD and SPG4]. | To determine the value of diffusion weighted imaging (DWI) in the diagnosis of hereditary spinocerebellar ataxia 3 and the Machado Joseph disease (SCA3/MJD) and hereditary spastic paraplegia 4 (SPG4). We scanned 13 patients with SPG4, 30 patients with SCA3/MJD (21 onset patients and 9 with only genetic abnormalities), ... | 25,202,952 | [
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[Efficiency and outcome of Boari bladder flap plasty surgery for the treatment of middle and lower ureteral carcinoma]. | To study the effect and outcome of Boari bladder flap plasty surgery for the treatment of kidney-sparing strategy for patients with middle and lower ureteral carcinoma. Database at the department of urology in the Second Xiangya Hospital from 2002-2007 was screened and all cases of primary solitary lower ureteral carci... | 25,202,956 | [
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CD45 ligation expands Tregs by promoting interactions with DCs. | Regulatory T cells (Tregs), which express CD4 and FOXP3, are critical for modulating the immune response and promoting immune tolerance. Consequently, methods to expand Tregs for therapeutic use are of great interest. While transfer of Tregs after massive ex vivo expansion can be achieved, in vivo expansion of Tregs wo... | 25,202,978 | [
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Deranged NMDAergic cortico-subthalamic transmission underlies parkinsonian motor deficits. | Parkinson's disease (PD) is the most prevalent hypokinetic movement disorder, and symptomatic PD pathogenesis has been ascribed to imbalances between the direct and indirect pathways in the basal ganglia circuitry. Here, we applied glutamate receptor blockers to the subthalamic nucleus (STN) of parkinsonian rats and ev... | 25,202,982 | [
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A recommendation for revised dose calibrator measurement procedures for 89Zr and 124I. | Because of their chemical properties and multiday half lives, iodine-124 and zirconium-89 are being used in a growing number of PET imaging studies. Some aspects of their quantitation, however, still need attention. For (89)Zr the PET images should, in principle, be as quantitatively accurate as similarly reconstructed... | 25,202,987 | [
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Oral zinc for arterial and venous leg ulcers. | Leg ulcers affect up to one percent of people at some time in their life. Leg ulceration is chronic in nature and ulcers may be present for months or even years without healing. After healing there is a high risk of recurrence. Treatments include wound dressings alongside the treatment of underlying medical problems su... | 25,202,988 | [
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Diffusion tensor imaging of brain abnormalities induced by prenatal exposure to radiation in rodents. | We assessed brain abnormalities in rats exposed prenatally to radiation (X-rays) using magnetic resonance imaging (MRI) and histological experiments. Pregnant rats were divided into 4 groups: the control group (n = 3) and 3 groups that were exposed to different radiation doses (0.5, 1.0, or 1.5 Gy; n = 3 each). Brain a... | 25,202,992 | [
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Angelica Sinensis polysaccharides stimulated UDP-sugar synthase genes through promoting gene expression of IGF-1 and IGF1R in chondrocytes: promoting anti-osteoarthritic activity. | Osteoarthritis (OA) is a chronic joints disease characterized by progressive degeneration of articular cartilage due to the loss of cartilage matrix. Previously, we found, for the first time, that an acidic glycan from Angelica Sinensis Polysaccharides (APSs), namely the APS-3c, could protect rat cartilage from OA due ... | 25,202,993 | [
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Effects of mental practice in novice learners in a serial positioning skill acquisition. | The effects of mental practice in novices were investigated. University students (N = 60) performed a serial aiming task, distributed in 5 groups of 12: mental practice, physical practice, mental-physical practice (first mental then physical practice), physical-mental practice (first physical then mental practice), and... | 25,202,997 | [
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Relationship between tactics and energy expenditure according to level of experience in badminton. | Research on racket sports has traditionally focused on expert players and has treated energy expenditure and tactics as independent factors. These prior studies could not assess how energy expenditure and tactics changed as a function of experience and skill. Here, the specific relationship between playing tactics and ... | 25,202,998 | [
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Bidirectional relationship of hypertension with obstructive sleep apnea. | Hypertension (HTN) and obstructive sleep apnea (OSA) are coexistent in millions of people, and both have been associated with heart disease, stroke, and premature death. OSA is an important risk factor for HTN. However, the relationship between OSA and HTN may be bidirectional, with high blood pressure (BP) contributin... | 25,203,003 | [
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Patents or patients: who loses? | The unprecedented weakening of patent rights in the United States undermines necessary incentives for the discovery and development of innovative medicines. | 25,203,034 | [
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Reanalyses of randomized clinical trial data. | Reanalyses of randomized clinical trial (RCT) data may help the scientific community assess the validity of reported trial results. To identify published reanalyses of RCT data, to characterize methodological and other differences between the original trial and reanalysis, to evaluate the independence of authors perfor... | 25,203,082 | [
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Management of sickle cell disease: summary of the 2014 evidence-based report by expert panel members. | Sickle cell disease (SCD) is a life-threatening genetic disorder affecting nearly 100,000 individuals in the United States and is associated with many acute and chronic complications requiring immediate medical attention. Two disease-modifying therapies, hydroxyurea and long-term blood transfusions, are available but u... | 25,203,083 | [
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The short-chain fatty acid uptake fluxes by mice on a guar gum supplemented diet associate with amelioration of major biomarkers of the metabolic syndrome. | Studies with dietary supplementation of various types of fibers have shown beneficial effects on symptoms of the metabolic syndrome. Short-chain fatty acids (SCFAs), the main products of intestinal bacterial fermentation of dietary fiber, have been suggested to play a key role. Whether the concentration of SCFAs or the... | 25,203,112 | [
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Interstitial lung disease associated with the idiopathic inflammatory myopathies and the antisynthetase syndrome: recent advances. | To highlight recent advances in understanding the clinical spectrum, pathogenesis, and treatment of interstitial lung disease associated with inflammatory myositis and the antisynthetase syndrome. In recent years, serologic tests to identify the less common antisynthetase antibodies and the anti-MDA-5 antibody have bec... | 25,203,119 | [
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Vessel labeling in combined confocal scanning laser ophthalmoscopy and optical coherence tomography images: criteria for blood vessel discrimination. | The diagnostic potential of optical coherence tomography (OCT) in neurological diseases is intensively discussed. Besides the sectional view of the retina, modern OCT scanners produce a simultaneous top-view confocal scanning laser ophthalmoscopy (cSLO) image including the option to evaluate retinal vessels. A correct ... | 25,203,135 | [
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A systematic health assessment of indian ocean bottlenose (Tursiops aduncus) and indo-pacific humpback (Sousa plumbea) dolphins incidentally caught in shark nets off the KwaZulu-Natal Coast, South Africa. | Coastal dolphins are regarded as indicators of changes in coastal marine ecosystem health that could impact humans utilizing the marine environment for food or recreation. Necropsy and histology examinations were performed on 35 Indian Ocean bottlenose dolphins (Tursiops aduncus) and five Indo-Pacific humpback dolphins... | 25,203,143 | [
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Variation in capsidiol sensitivity between Phytophthora infestans and Phytophthora capsici is consistent with their host range. | Plants protect themselves against a variety of invading pathogenic organisms via sophisticated defence mechanisms. These responses include deployment of specialized antimicrobial compounds, such as phytoalexins, that rapidly accumulate at pathogen infection sites. However, the extent to which these compounds contribute... | 25,203,155 | [
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Effect of Angiotensin converting enzyme inhibitors on soluble tumor-necrosis-factor-related apoptosis-inducing ligand levels - association with neointimal hyperplasia in drug eluting stents. | To test the hypothesis that angiotensin converting enzyme inhibitors (ACEi) affect soluble tumor-necrosis-factor-related apoptosis-inducing ligand (sTRAIL) and this interaction is associated with less in-drug-eluting-stent (DES) neointimal hyperplasia following percutaneous coronary intervention (PCI). From our databas... | 25,203,156 | [
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Swimming motility in a longitudinal collection of clinical isolates of Burkholderia cepacia complex bacteria from people with cystic fibrosis. | Chronic bacterial lung infections in cystic fibrosis (CF) are the leading cause of morbidity and mortality. While a range of bacteria are known to be capable of establishing residence in the CF lung, only a small number have a clearly established link to deteriorating clinical status. The two bacteria with the clearest... | 25,203,161 | [
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Inhibitory control and error monitoring by human subthalamic neurons. | The subthalamic nucleus (STN) has been shown to be implicated in the control of voluntary action, especially during tasks involving conflicting choice alternatives or rapid response suppression. However, the precise role of the STN during nonmotor functions remains controversial. First, we tested whether functionally d... | 25,203,170 | [
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Antimicrobial stewardship programs in inpatient hospital settings: a systematic review. | Evaluate the evidence for effects of inpatient antimicrobial stewardship programs (ASPs) on patient, prescribing, and microbial outcomes. Systematic review. Search of MEDLINE (2000 through November 2013), Cochrane Library, and reference lists of relevant studies. We included English language studies with patient popula... | 25,203,174 | [
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Antibiotic prescribing practices in a multicenter cohort of patients hospitalized for acute bacterial skin and skin structure infection. | Hospitalizations for acute bacterial skin and skin structure infection (ABSSSI) are common. Optimizing antibiotic use for ABSSSIs requires an understanding of current management. The objective of this study was to evaluate antibiotic prescribing practices and factors affecting prescribing in a diverse group of hospital... | 25,203,177 | [
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Valuation of hospital bed-days released by infection control programs: a comparison of methods. | We performed a contingent valuation survey to elicit the opportunity cost of bed-days consumed by healthcare-associated infections in 11 European hospitals. The opportunity cost of a bed-day was significantly lower than the accounting cost; median values were €72 and €929, respectively (P < .001). Accounting methods... | 25,203,185 | [
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Double pancake bonds: pushing the limits of strong π-π stacking interactions. | The concept of a double-bonded pancake bonding mechanism is introduced to explain the extremely short π-π stacking contacts in dimers of dithiatriazines. While ordinary single pancake bonds occur between radicals and already display significantly shorter interatomic distances in comparison to van der Waals (vdW) contac... | 25,203,200 | [
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Flipping a phosphate switch on kinesin-II to turn IFT around. | Cilia and flagella are assembled and maintained by the motor-driven, bidirectional traffic of large protein complexes in a process termed intraflagellar transport (IFT). In this issue of Developmental Cell, Liang et al. (2014) report that IFT is regulated in part by the phosphorylation status of the kinesin-II subunit ... | 25,203,204 | [
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Laser-induced breakdown spectroscopy for 24/7 automatic liquid slag analysis at a steel works. | Laser-induced breakdown spectroscopy (LIBS) is applied for the inline analysis of liquid slag at a steel works. The slag in the ladle of a slag transporter is measured at a distance of several meters during a short stop of the transporter. The slag surface with temperatures from ≈600 to ≈1400 °C consists of liquid slag... | 25,203,225 | [
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Risk Estimation Modeling and Feasibility Testing for a Mobile eHealth Intervention for Binge Drinking Among Young People: The D-ARIANNA (Digital-Alcohol RIsk Alertness Notifying Network for Adolescents and young adults) Project. | Binge drinking is common among young people but often relevant risk factors are not recognized. eHealth apps, attractive for young people, may be useful to enhance awareness of this problem. We aimed at developing a current risk estimation model for binge drinking, incorporated into an eHealth app--D-ARIANNA (Digital-A... | 25,203,226 | [
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Biochar from Alternanthera philoxeroides could remove Pb(II) efficiently. | A novel bio-adsorbent was successfully synthesized by pyrolyzing Alternanthera philoxeroides (AP), one of the most widely used hydrophytes for eutrophic lake ecological restoration under O2-limited condition at 600 °C. Compared with commercially active carbon (AC), the initial solution pH had a weak effect on the adsor... | 25,203,230 | [
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In the shadowlands of global health: observations from health workers in Kenya. | During the past decade, donor funding for health interventions in Kenya and other African countries has risen sharply. Focused on high-profile diseases such as HIV/AIDS, these funds create islands of intervention in a sea of under-resourced public health services. This paper draws on ethnographic research conducted in ... | 25,203,252 | [
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Correlation of Klebsiella pneumoniae comparative genetic analyses with virulence profiles in a murine respiratory disease model. | Klebsiella pneumoniae is a bacterial pathogen of worldwide importance and a significant contributor to multiple disease presentations associated with both nosocomial and community acquired disease. ATCC 43816 is a well-studied K. pneumoniae strain which is capable of causing an acute respiratory disease in surrogate an... | 25,203,254 | [
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Recruiting, hiring, and retaining good employees. | More pharmacists and other health care professionals often feel unprepared when engaged in the hiring process. This can occur both when looking for a new job and when participating as part of the hiring team. In this article, experts in strategies for recruiting, hiring, and retaining employees provide insight into suc... | 25,203,259 | [
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Peptide coupling between amino acids and the carboxylic acid of a functionalized chlorido-gold(I)-phosphane. | We have developed a protocol for the direct coupling between methyl ester protected amino acids and the chlorido-gold(I)-phosphane (p-HOOC(C6H4)PPh2)AuCl. By applying the EDC·HCl/NHS strategy (EDC·HCl = N-ethyl-N'-(3-(dimethylamino)propyl)carbodiimide hydrochloride, NHS = N-hydroxysuccinimide), the methyl esters of l-p... | 25,203,269 | [
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Relating hippocampus to relational memory processing across domains and delays. | The hippocampus has been implicated in a diverse set of cognitive domains and paradigms, including cognitive mapping, long-term memory, and relational memory, at long or short study-test intervals. Despite the diversity of these areas, their association with the hippocampus may rely on an underlying commonality of rela... | 25,203,273 | [
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Another role for CO with nitrogenase? CO stimulates hydrogen evolution catalyzed by variant Azotobacter vinelandii Mo-nitrogenases. | A likely entry/exit path for nitrogenase substrates, products, and/or protons involves residues α277(Arg), α192(Ser), and α356(Gly), all of which are highly conserved among MoFe proteins from different organisms. The α192(Ser) and α277(Arg) residues form part of a hydrogen-bonded network that also involves α195(His), w... | 25,203,280 | [
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Transcranial Direct Current Stimulation for Treating Depression in a Patient With Right Hemispheric Dominance: A Case Study. | We report the case of a 66-year-old male patient with major depressive disorder for the last 6 months. The patient had been diagnosed with dyslexia during childhood and was left-handed. The intervention protocol consisted in 10 consecutive daily transcranial direct current stimulation sessions. However, after 5 days of... | 25,203,287 | [
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Electroconvulsive therapy and its association with demographic and clinical characteristics in Chinese psychiatric patients. | Little is known about the frequency of electroconvulsive therapy (ECT) use in China. This study examined the frequency of ECT and its relationship with demographic and clinical characteristics in a large psychiatric institution in China. This was a retrospective chart review of all the 19,982 inpatients aged 18 to 59 y... | 25,203,288 | [
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A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer. | In a genome-wide survey on somatic copy-number alterations (SCNAs) of long noncoding RNA (lncRNA) in 2,394 tumor specimens from 12 cancer types, we found that about 21.8% of lncRNA genes were located in regions with focal SCNAs. By integrating bioinformatics analyses of lncRNA SCNAs and expression with functional scree... | 25,203,321 | [
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Patterns and frequency of the treatment of depression in persons with epilepsy. | Though depression is common in persons with epilepsy, it often remains undiagnosed and/or untreated. The current study aimed to determine the proportion of persons with epilepsy receiving depression-related treatment and to characterize the type of treatment received. Persons with epilepsy (n=185) from the only epileps... | 25,203,325 | [
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Can noise cause high blood pressure? Occupational risk in paper industry. | The authors hypothesize cardiovascular effects in paper industry workers exposed to noise. The study included 72 paper industry workers exposed to noise and two control groups not exposed to noise. The workers completed a questionnaire and underwent a medical examination, measurement of blood pressure, electrocardiogra... | 25,203,347 | [
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Velocity thresholds for women's soccer matches: sex specificity dictates high-speed running and sprinting thresholds - Female Athletes in Motion (FAiM). | There is no methodological standardization of velocity thresholds for the quantification of distances covered in various locomotor activities for women's soccer matches, especially for high-speed running and sprinting. Applying velocity thresholds used for motion analysis of men's soccer has likely created skewed obser... | 25,203,354 | [
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A new tonometric device for radial augmentation index and subendocardial viability ratio: potential use in health screening. | Augmentation index (AIx) and subendocardial viability ratio (SEVR) are widely accepted indices of wave reflection and myocardial oxygen demand relative to supply. This study aimed to validate a new tonometric device (IIM-2010A) for obtaining AIx and SEVR from radial artery. A total of 68 outpatients (32 men and 36 wome... | 25,203,355 | [
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Long-term therapeutic effectiveness of maintenance enteral nutrition for Crohn's disease. | Long-term effectiveness of enteral nutrition for maintaining remission in pediatric Crohn's disease (CD) is poorly documented. The aim of this study was therefore to examine the long-term effectiveness of enteral nutrition with aminosalicylates as maintenance therapy for those in whom remission was primarily induced by... | 25,203,356 | [
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Scanning probe microscopy investigations of the electrical properties of chemical vapor deposited graphene grown on a 6H-SiC substrate. | Sublimated graphene grown on SiC is an attractive material for scientific investigations. Nevertheless the self limiting process on the Si face and its sensitivity to the surface quality of the SiC substrates may be unfavourable for later microelectronic processes. On the other hand, chemical vapor deposited (CVD) grap... | 25,203,361 | [
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What obstetrician-gynecologists should know about Ebola: a perspective from the Centers for Disease Control and Prevention. | West Africa is currently in the midst of the largest Ebola outbreak in history. Although there have been no Ebola virus disease cases identified in the United States, two U.S. health care workers with Ebola virus disease were medically evacuated from Liberia to the United States in early August 2014. The Centers for Di... | 25,203,368 | [
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Sacral resection with pelvic exenteration for advanced primary and recurrent pelvic cancer: a single-institution experience of 100 sacrectomies. | Recurrent and advanced primary pelvic cancers present a complex clinical issue requiring multidisciplinary care and radical extended surgery. Sacral resection is necessary for tumors that invade posteriorly but is associated with increased morbidity and mortality. This study aimed to analyze the morbidity and survival ... | 25,203,370 | [
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The potential impact of white-nose syndrome on the conservation status of north american bats. | White-Nose syndrome (WNS) is an emergent infectious disease that has already killed around six million bats in North America and has spread over two thousand kilometers from its epicenter. However, only a few studies on the possible impacts of the fungus on bat hosts were conducted, particularly concerning its implicat... | 25,203,391 | [
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Identification of structurally diverse methanofuran coenzymes in methanococcales that are both N-formylated and N-acetylated. | Methanofuran (MF) is a coenzyme necessary for the first step of methanogenesis from CO2. The well-characterized MF core structure is 4-[N-(γ-l-glutamyl-γ-l-glutamyl)-p-(β-aminoethyl)phenoxymethyl]-2-(aminomethyl)furan (APMF-γ-Glu2). Three different MF structures that differ on the basis of the composition of their side... | 25,203,397 | [
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Medicare Part D: Pharmacists and formularies--whose job is it to address copays? | To explore pharmacists' perceived responsibility to assist Part D patients in the community in managing their out-of-pocket (OOP) costs as well as pharmacists' overall experience with Medicare Part D. Cross-sectional analysis. Maine, New Jersey, New York, Massachusetts, Maryland, and Pennsylvania. 272 pharmacists. 37-q... | 25,203,409 | [
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Fidaxomicin: a novel macrolide antibiotic for Clostridium difficile infection. | To review the chemistry, pharmacology, microbiology, pharmacodynamics, pharmacokinetics, clinical efficacy, tolerability, drug interactions, dosing, and administration of fidaxomicin (FDX). A search of PubMed using the terms "fidaxomicin," "OPT-80," "PAR-101," "OP-1118," "difimicin," "tiacumicin," and "lipiarmycin" was... | 25,203,410 | [
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Unimolecular reactions of 1,1,1-trichloroethane, 1,1,1-trichloropropane, and 3,3,3-trifluoro-1,1,1-trichloropropane: determination of threshold energies by chemical activation. | The recombination of CCl3 radicals with CH3, CH3CH2, and CF3CH2 radicals was used to generate CH3CCl3, CH3CH2CCl3, and CF3CH2CCl3 molecules with approximately 87 kcal mol(-1) of vibrational energy in a bath gas at room temperature. The competition between collisional deactivation and unimolecular reaction by HCl elimin... | 25,203,415 | [
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Comparing the Personality Disorder Interview for DSM-IV (PDI-IV) and SCID-II borderline personality disorder scales: an item-response theory analysis. | One-hundred sixty-nine psychiatric outpatients and 171 undergraduate students were assessed with the Personality Disorder Interview-IV (PDI-IV; Widiger, Mangine, Corbitt, Ellis, & Thomas, 1995) and the Structured Clinical Interview for DSM-IV Axis II disorders (SCID-II; First, Gibbon, Spitzer, Williams, & Benja... | 25,203,418 | [
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The functional TP53 rs1042522 and MDM4 rs4245739 genetic variants contribute to Non-Hodgkin lymphoma risk. | As a heterogeneous kind of malignances, Non-Hodgkin lymphoma (NHL) is the most common hematologic cancer worldwide with the significantly increased morbidity in China. Accumulated evidences demonstrated that oncoprotein MDM4 plays a crucial role in the TP53 tumor suppressor signaling pathway. An rs4245739 A>C polymo... | 25,203,442 | [
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De-differentiation confers multidrug resistance via noncanonical PERK-Nrf2 signaling. | Malignant carcinomas that recur following therapy are typically de-differentiated and multidrug resistant (MDR). De-differentiated cancer cells acquire MDR by up-regulating reactive oxygen species (ROS)-scavenging enzymes and drug efflux pumps, but how these genes are up-regulated in response to de-differentiation is n... | 25,203,443 | [
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High need for MMR vaccination in HIV infected adults in Austria. | Current guidelines recommend screening for HIV infected patients susceptible for vaccine preventable diseases and offering of immunization. However, data regarding the vaccination coverage among this group are largely missing. This study analyzed the serostatus for Measles, Mumps and Rubella of more than 700 HIV infect... | 25,203,449 | [
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A comparison of strategies for imputing saturated pressure array data with application to the wheelchair-seating interface. | The common responses to pressure sensor saturation are extreme: either discarding of data, or wholesale alteration of experimental protocol. Here, we test four simplistic strategies for restoring missing data due to sensor saturation, avoiding such drastic measures. We tested these algorithms on 62 pressure maps collec... | 25,203,501 | [
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Inducible Costimulator Gene-Transduced Bone Marrow-Derived Mesenchymal Stem Cells Attenuate the Severity of Acute Graft-Versus-Host Disease in Mouse Models. | In murine allogeneic transplantation models, ICOS gene-transduced bone marrow-derived mesenchymal stem cells (MSCs(ICOS-EGFP)) were evaluated for their effects on GvHD severity and long-term survival. Lethally irradiated BALB/c or first filial generation of BALB/c and C57BL/6 (CB6F1) mice were transplanted with bone ma... | 25,203,502 | [
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... |
LeoA, B and C from enterotoxigenic Escherichia coli (ETEC) are bacterial dynamins. | Escherichia coli (ETEC) strain H10407 contains a GTPase virulence factor, LeoA, which is encoded on a pathogenicity island and has been shown to enhance toxin release, potentially through vesicle secretion. By sequence comparisons and X-ray structure determination we now identify LeoA as a bacterial dynamin-like protei... | 25,203,511 | [
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The effect of pre-oxidation on NDMA formation and the influence of pH. | N-nitrosodimethylamine (NDMA), a probable human carcinogen, is a disinfection by-product that has been detected in chloraminated drinking water systems. Pre-oxidation of the NDMA precursors prior to chloramination can be a viable approach for water utilities to control the NDMA levels. This study examined the effects o... | 25,203,542 | [
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Neonatal clavicular fracture: recent 10 year study. | The clavicle is the bone most frequently fractured during the delivery process. A retrospective review was performed of all births with clavicular fractures from January 2003 to December 2012. Risk factors for fracture were determined and then compared to the control group. The data were compared and analyzed with prev... | 25,203,556 | [
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An open label study to evaluate the safety and efficacy of intratympanic golimumab therapy in patients with autoimmune inner ear disease. | To evaluate the safety and efficacy of intratympanically injected golimumab (GLM), a TNF-α inhibitor, as a steroid-sparing agent for patients with steroid-dependent autoimmune inner ear disease (AIED). Open label. Tertiary referral center. Ten patients with steroid-dependent AIED were enrolled in Stage 2. The average p... | 25,203,561 | [
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An undetected intraorbital foreign body after a "trivial" facial injury. | Intraorbital foreign objects are common after high-velocity injuries and can result in disastrous consequences. A "trivial" facial injury may sometimes obscure the presence of an intraorbital foreign object. Difficulties in the approach to the intraconal space and possible surgical morbidity to the optic nerve make man... | 25,203,575 | [
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Craniofacial morphologic parameters in a Persian population: an anthropometric study. | Limited data are available regarding the reference ranges of facial proportions of the Persian population in Iran. This study aimed to establish the reference range of craniofacial anthropometric measurements in an adult Iranian population. On 100 individuals (men = women), aged 18 to 30 years with normal faces and occ... | 25,203,584 | [
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Association between chemokine receptor 5 delta32 polymorphism and susceptibility to cancer: a meta-analysis. | To explore whether the functional chemokine receptor 5 delta32 (CCR5-Δ32) polymorphism is associated with susceptibility to cancer. A meta-analysis was conducted on the association between the CCR5-Δ32 polymorphism and cancer using (i) allele contrast and (ii) the dominant model. Thirteen articles, including 16 compara... | 25,203,595 | [
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A systematic investigation of polymer binder flexibility on the electrode performance of lithium-ion batteries. | The mechanical failure at the electrode interfaces (laminate/current collector and binder/particle interfaces) leads to particle isolation and delamination, which has been regarded as one of the main reasons for the capacity decay and cell failure of lithium-ion batteries (LIBs). Polymer binder provides the key functio... | 25,203,598 | [
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The importance of internal facial features in learning new faces. | For familiar faces, the internal features (eyes, nose, and mouth) are known to be differentially salient for recognition compared to external features such as hairstyle. Two experiments are reported that investigate how this internal feature advantage accrues as a face becomes familiar. In Experiment 1, we tested the c... | 25,203,612 | [
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Genetic diversity and dynamics of bacterial and yeast strains associated to Spanish-style green table-olive fermentations in large manufacturing companies. | We have genotyped a total of 1045 microbial isolates obtained along the fermentation time of Spanish-style green table olives from the fermentation yards (patios) of two large manufacturing companies in the Province of Sevilla, south of Spain. Genotyping was carried out using RAPD-PCR fingerprinting. In general, isolat... | 25,203,617 | [
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0.5454004,
0.3966644,
-0.3975585,
0.026... |
Repeatability of sound-evoked triceps myogenic potentials. | To investigate the repeatability of sound-evoked vestibular evoked myogenic potentials recorded from the triceps (tVEMPs) with and without visual feedback. tVEMP responses to 95 dB nHL 500-Hz tone bursts were recorded in a longitudinal, repeated measures study where P1 and N1 latencies and amplitudes were measured on t... | 25,203,621 | [
-0.1807772,
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-0.03323454,
-0.05612308,
-0.05657077,
-0.00... |
Effect of particle size on osteoinductive potential of microstructured biphasic calcium phosphate ceramic. | Material factors such as chemistry, surface microstructure and geometry have shown their influence on osteoinduction of calcium phosphate ceramics. Hereby we report that osteoinduction of a micro-structured biphasic calcium phosphate ceramic (BCP) has a relation with the particle sizes. BCP particles with the size of 2... | 25,203,625 | [
-0.2022751,
0.09928818,
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0.01249326,
0.2795086,
0.04929... |
S-Adenosyl-L-methionine-competitive inhibitors of the histone methyltransferase EZH2 induce autophagy and enhance drug sensitivity in cancer cells. | The enhancer of zeste homolog 2 (EZH2) has emerged as a novel anticancer target. Various EZH2 inhibitors have been developed in recent years. Among these, 3-deazaneplanocin A (DZNep) is known to deplete EZH2 protein expression through an indirect pathway. In contrast, GSK343 directly inhibits enzyme activity through an... | 25,203,626 | [
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0.1452673,
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0.03768091,
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0... |
Maternal exposure to brominated flame retardants and infant Apgar scores. | Brominated flame retardants (BFRs) and other persistent organic pollutants have been associated with adverse health outcomes in humans and may be particularly toxic to the developing fetus. We investigated the association between in utero polybrominated biphenyl (PBB) and polychlorinated biphenyl (PCB) exposures and in... | 25,203,650 | [
-0.2278112,
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Nickel-rich layered microspheres cathodes: lithium/nickel disordering and electrochemical performance. | Nickel-rich layered metal oxide materials are prospective cathode materials for lithium ion batteries due to the relatively higher capacity and lower cost than LiCoO2. Nevertheless, the disordered arrangement of Li(+)/Ni(2+) in local regions of these materials and its impact on electrochemistry performance are not well... | 25,203,668 | [
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0.171184,
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0.1322303,
0.1381621,
... |
The aryl hydrocarbon receptor: differential contribution to T helper 17 and T cytotoxic 17 cell development. | The aryl hydrocarbon receptor (AhR) has been shown to be required for optimal Thelper (Th) 17 cell activation. Th17 cells provide immunity against extracellular pathogens and are implicated in autoimmune diseases. Herein, the role of the AhR in cytokine production by Th17, and by the analogous population of T cytotoxic... | 25,203,682 | [
-0.01181407,
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0.1316418,
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0.3058955,
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0.292863,
-0.177077... |
Impurity-band transport in organic spin valves. | The central phenomenon in the field of organic spintronics is the large magnetoresistance in thick organic spin valves. A prerequisite for understanding the magnetoresistance is a reliable description of the device resistance, or the I-V characteristics. Here I show that the observed I-V characteristics in the organic ... | 25,203,690 | [
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0.1952916,
0.1604697,
0.265812,
0.1726075,
0.06275094,
-0.0662990... |
Development of porous polyurethane/strontium-substituted hydroxyapatite composites for bone regeneration. | Polyurethane (PU) has been widely used for the biomedical applications but its potential for bone regeneration is limited due to its lack of osteoconductive properties. Strontium substituted hydroxyapatite (SrHA) particles, on the other hand, are known to exhibit a positive effect on bone formation. Therefore, the aim ... | 25,203,691 | [
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0.4642203,
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0.2515578,
0.1701779,
... |
True aneurysms of the superficial temporal artery: Diagnosis and treatment. | True aneurysms arising from the superficial temporal artery (STA) are quite uncommon. The present study reviews the surgical experience with true STA aneurysms to describe the clinical features and treatment options. This study comprised of 12 patients (6 female; mean age, 44.7 years) of spontaneous aneurysms of the ST... | 25,203,714 | [
0.0032257,
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0.04337299,
0.1482315,
0.1081828,
0.1018394,
-0.07305446,
0.26... |
Exploring marine resources for bioactive compounds. | Biodiversity in the seas is only partly explored, although marine organisms are excellent sources for many industrial products. Through close co-operation between industrial and academic partners, it is possible to successfully collect, isolate and classify marine organisms, such as bacteria, fungi, micro- and macroalg... | 25,203,732 | [
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0.3488053,
0.3723087,
0.0874142,
0.3304177,
0.2689473,
-0.5403947,
-0... |
Prognostic impact of the c-MET polymorphism on the clinical outcome in locoregional gastric cancer patients. | Dysregulation of the c-MET signaling pathway results from various molecular mechanisms including mutation, amplification, and overexpression. Overexpression and amplification of c-MET have been correlated with poor clinical outcome in gastric cancer, whereas the associations between c-MET polymorphisms and prognosis ha... | 25,203,738 | [
0.05136749,
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0.3310116,
0.3231733,
0.09754554,
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0.2... |
Sequence-specific DNA detection at 10 fM by electromechanical signal transduction. | Target DNA fragments at 10 fM concentration (approximately 6 × 10(5) molecules) were detected against a DNA background simulating the noncomplementary genomic DNA present in real samples using a simple, PCR-free, optics-free approach based on electromechanical signal transduction. The development of a rapid, sensitive,... | 25,203,740 | [
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0.4598183,
-0.1259193,
-0.174486,
... |
Species-specific activation of TLR4 by hypoacylated endotoxins governed by residues 82 and 122 of MD-2. | The Toll-like receptor 4/MD-2 receptor complex recognizes endotoxin, a Gram-negative bacterial cell envelope component. Recognition of the most potent hexaacylated form of endotoxin is mediated by the sixth acyl chain that protrudes from the MD-2 hydrophobic pocket and bridges TLR4/MD-2 to the neighboring TLR4 ectodoma... | 25,203,747 | [
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0.00161854,
-0.03678192,
0.3697653,
0.4485289,
-0.1... |
Discovery of small molecular inhibitors targeting HIV-1 gp120-CD4 interaction drived from BMS-378806. | The HIV-1 entry into host cells is a complex, multi-factors involved, and multi-step process. Especially, the attachment of HIV-1 envelope glycoprotein gp120 to the host cell receptor CD4 is the first key step during entry process, representing a promising antiviral therapeutic target. Among the HIV-1 attachment inhibi... | 25,203,778 | [
-0.1635278,
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0.1147855,
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0.0997682,
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0.2786504,
-0.1359083... |
Novel sulfonyl(thio)urea derivatives act efficiently both as insulin secretagogues and as insulinomimetic compounds. | Glibenclamide is widely used in the management of non-insulin dependent diabetes mellitus, but numerous risks limit its use in therapy. In the search for novel structures that are safer and more efficient than glibenclamide, we obtained new chemical analogs based on bioisosterism, through the treatment of benzenesulfon... | 25,203,779 | [
-0.4921775,
0.10568,
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0.06199018,
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0.2010793,
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-0.03006592,
0.2472259,
-0.028341... |
Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups. | Several largazole analogues with modified surface recognition cap groups were synthesized and their HDAC inhibitory activities were determined. The C7-epimer 12 caused negligible inhibition of HDAC activity, failed to induce global histone 3 (H3) acetylation in the HCT116 colorectal cancer cell line and demonstrated mi... | 25,203,782 | [
0.01870468,
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0.2128825,
0.5249706,
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... |
An in situ directing group strategy for chiral anion phase-transfer fluorination of allylic alcohols. | An enantioselective fluorination of allylic alcohols under chiral anion phase-transfer conditions is reported. The in situ generation of a directing group proved crucial for achieving effective enantiocontrol. In the presence of such a directing group, a range of acyclic substrates underwent fluorination to afford high... | 25,203,796 | [
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[Retrospective analysis of the efficacy and safety of anti-hepatitis B virus drugs taken during pregnancy in women from the Guangdong Province]. | To investigate the efficacy of anti-hepatitis B virus (HBV) drugs for preventing vertical transmission of HBV and the safety of these drugs when given as treatment during pregnancy (to women) or insemination (to men). Cases of women and men who had taken anti-HBV drug therapy during pregnancy or insemination, respectiv... | 25,203,798 | [
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0.4116941,
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0.07923087,
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0.2723892,
-0.3834067,
0.292... |
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