title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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[The value of multi-slice spiral computed tomography portography in assessing severity of liver cirrhosis and predicting episode risks of hepatic encephalopathy]. | To explore the clinical value of multi-slice spiral computed tomography portography (MSCTP) in assessing severity of liver cirrhosis and predicting episode risks of hepatic encephalopathy (HE). Eighty-six patients with liver cirrhosis who were hospitalized in the Department of Gastroenterology at the Affiliated Hospita... | 25,203,802 | [
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[Nutritional risk assessment in patients with chronic liver disease]. | To use the European Nutritional Risk Screening (NRS)-2002 survey tool to investigate nutritional risk associated to different degrees of liver disease and to assess its ability to identify the nutritional risk of hospitalized patients with chronic liver disease. A total of 366 hospitalized patients were assessed with t... | 25,203,807 | [
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[A reduced TKI dosage is not associated with loss of activity in EGFR mutated NSCLC patients]. | Patients treated with anti-EGFR tyrosine kinase inhibitors (TKI) may receive dose reduction due to toxicity; however, the impact on treatment efficacy and patient outcome remains unknown. Patients with stage IV NSCLC harbouring EGFR mutations and treated at our institution were retrospectively analyzed for treatment wi... | 25,203,821 | [
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The interactions of TGF-beta signalling pathway and Jagged2/Notch1 pathway induce acanthosis in lingual epithelia. | The aims of this study were to distinguish between the primary and secondary effects of TGF-β signalling disruption by Dox treatment in NTPDase2+ cells; and to investigate the interactions between TGF-β signalling and Jagged2/Notch1 pathway in regulating the expansion of tongue epithelia stem cells.Transgenic mice expr... | 25,203,837 | [
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Workflow for combined proteomics and glycomics profiling from histological tissues. | Extracellular matrixes comprise glycoproteins, glycosaminoglycans and proteoglycans that order the environment through which cells receive signals and communicate. Proteomic and glycomic molecular signatures from tissue surfaces can add diagnostic power to the immunohistochemistry workflows. Acquired in a spatially res... | 25,203,838 | [
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Radiotherapy-induced skin reactions: prevention and cure. | This article describes the prophylactic use of Mepitel Film in three breast-cancer patients undergoing adjuvant radiotherapy. Each patient had significant risk factors for developing severe radiotherapy-induced skin reactions. This article details the experience encountered by these patients through their treatment cou... | 25,203,851 | [
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Avoiding accidental exposure to intravenous cytotoxic drugs. | Many cytotoxic drugs have been shown to be mutagenic, teratogenic and carcinogenic with second malignancies known to be associated with several specific cancer drugs. Occupational exposure to cytotoxic drugs presents a signification danger to healthcare staff and unwarranted handling of these drugs should be avoided. G... | 25,203,853 | [
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Template-free ordered mesoporous silicas by binary nanoparticle assembly. | Evaporation-induced convective binary assembly of large (A) and small (B) silica nanoparticles is demonstrated as a template-free route to three-dimensionally ordered mesoporous silicas (OMSs), the pore topology of which derives from the interconnected interstices of the resulting ordered nanoparticulate structures. Ev... | 25,203,868 | [
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Is there a relationship between patient satisfaction and favorable outcomes? | Patient satisfaction with the health care experience has become a top priority for Centers for Medicare and Medicaid Services. With resources and efforts directed at patient satisfaction, we evaluated whether high patient satisfaction measured by HCAHPS (Hospital Consumer Assessment of Healthcare Providers and Systems)... | 25,203,875 | [
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Total laparoscopic pancreaticoduodenectomy for pancreatic ductal adenocarcinoma: oncologic advantages over open approaches? | To directly compare the oncologic outcomes of TLPD and OPD in the setting of pancreatic ductal adenocarcinoma. Total laparoscopic pancreaticoduodenectomy (TLPD) has been demonstrated to be feasible and may have several potential advantages over open pancreaticoduodenectomy (OPD), including lower blood loss and shorter ... | 25,203,880 | [
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Differences in surgical outcomes between hepatitis B- and hepatitis C-related hepatocellular carcinoma: a retrospective analysis of a single North American center. | Compare surgical outcomes for hepatitis B virus (HBV)-hepatocellular carcinoma (HCC) versus hepatitis C virus (HCV)-hepatocellular carcinoma (HCC). HCC is the second leading cause of death from cancer worldwide and is associated with hepatitis virus infection in 80% of cases. Between 1997 and 2011, 1008 patients with h... | 25,203,882 | [
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Development of a new calibration procedure and its experimental validation applied to a human motion capture system. | Motion capture systems are often used for checking and analyzing human motion in biomechanical applications. It is important, in this context, that the systems provide the best possible accuracy. Among existing capture systems, optical systems are those with the highest accuracy. In this paper, the development of a new... | 25,203,903 | [
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Activity Profile of International Rugby Sevens: Effect of Score Line, Opponent, and Substitutes. | To investigate the influence of score line, level of opposition, and timing of substitutes on the activity profile of rugby sevens players and describe peak periods of activity. Velocity and distance data were measured via 10-Hz GPS from 17 international-level male rugby sevens players on 2-20 occasions over 4 tourname... | 25,203,905 | [
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Identification and characterization of an ecto-pyrophosphatase activity in intact epimastigotes of Trypanosoma rangeli. | In this study, we performed the molecular and biochemical characterization of an ecto-enzyme present in Trypanosoma rangeli that is involved with the hydrolysis of extracellular inorganic pyrophosphate. PCR analysis identified a putative proton-pyrophosphatase (H(+)-PPase) in the epimastigote forms of T. rangeli. This ... | 25,203,926 | [
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Factors controlling the enhanced mechanical and thermal properties of nanodiamond-reinforced cross-linked high density polyethylene. | A systematic investigation of the factors influencing the notable enhancement of the mechanical and thermal properties of nanodiamonds (NDs)-reinforced cross-linked high density polyethylene (PEX) is presented in this work. The effects of crystal structure and molecular conformation as well as filler dispersion and adh... | 25,203,933 | [
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Multiple sclerosis treatment with natalizumab: analysis of a hospital-based cohort. | Natalizumab is licensed as monotherapy for relapsing-remitting multiple sclerosis. Since pivotal studies showing natalizumab efficacy, several subsequent studies confirmed the reduction in annualized relapse rate and the slowing of disability progression. Nevertheless, 'real-world' data, namely in Portugal, are still s... | 25,203,951 | [
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Two-Stage Regularized Linear Discriminant Analysis for 2-D Data. | Fisher linear discriminant analysis (LDA) involves within-class and between-class covariance matrices. For 2-D data such as images, regularized LDA (RLDA) can improve LDA due to the regularized eigenvalues of the estimated within-class matrix. However, it fails to consider the eigenvectors and the estimated between-cla... | 25,204,000 | [
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Time to relapse after epilepsy surgery in children: AED withdrawal policies are a contributing factor. | It was recently suggested that early postoperative seizure relapse implicates a failure to define and resect the epileptogenic zone, that late recurrences reflect the persistence or re-emergence of epileptogenic pathology, and that early recurrences are associated with poor treatment response. Timing of antiepileptic d... | 25,204,012 | [
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Interleukin-18 gene polymorphisms in systemic lupus erythematosus: relation to disease status. | Systemic lupus erythematosus (SLE) is a multisystem autoimmune connective tissue disorder characterized by loss of self-tolerance causing immune-mediated tissue destruction and various clinical presentations Interleukin-18 (IL-18) is a proinflammatory cytokine that plays an important role in chronic inflammation and au... | 25,204,040 | [
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The role of regulatory T cells in preeclampsia. | Preeclampsia is a multisystem disorder of unknown cause that is unique to human pregnancy affecting about 7-10% of pregnant women. CD4+CD25(bright) regulatory T (Treg) cells have been identified as a principle regulator of tolerance during pregnancy. The aim of this study was to demonstrate the change of peripheral CD4... | 25,204,044 | [
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Efficacy of ferterra 0.4% GR (chlorantraniliprole) against stem borers and leaffolder insect-pests of basmati rice. | Field experiments were conducted during three kharif seasons from 2009 to 2011 at Sudhar village, Ludhiana and Rice Research Area of Department of Plant Breeding and Genetics, Punjab Agricultural University, Ludhiana. Four doses of Ferterra 0.4% GR (chlorantraniliprole) a new chemistry @ 20, 30, 40 and 50 g a.i. ha(-1)... | 25,204,052 | [
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Identification of simple sequence repeat markers associated with wilt resistance in pigeonpea. | The present study was carried out with the objective of identifying markers for Fusarium wilt resistance in pigeonpea using simple sequence repeat (SSR) and bulk segregant analysis (BSA). The wilt resistant (ICPL 87119) and wilt susceptible (T. Vishakha-1) genotypes were crossed and their F2 population was used for mar... | 25,204,073 | [
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Fibrinogen, bFGF and VEGF levels during antibiotic therapy in gynecologic cancer: a preliminary report. | The role of angiogenesis in the development of neoplasia has been identified and characterized. However, antiangiogenic therapeutic intervention still requires more evidence to become recognized and successful. The aim of this study was to evaluate levels of selected proangiogenic factors, such as fibrinogen, vascular ... | 25,204,086 | [
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[Profile of moral reasoning in persons with bipolar affective disorder]. | The subject of the research presented in this paper was to analyze the relationships between bipolar disorder (BD) and the profile of moral reasoning according to the concept of James Rest. 86 persons took part in the research, including 43 bipolar patients and 43 healthy individuals. To measure the severity of depress... | 25,204,095 | [
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[Life without childhood--parentification of women with ACoA syndrome]. | The aim of the study conducted on 110 women (55 research group, 55 control group) was to answer the question: If and what kind of parentification (role reversal in the family) do women with Adult Children of Alcoholics (ACoA) syndrome experience in comparison to women who did not experience parent's alcoholism in child... | 25,204,100 | [
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[Cognitive therapy of trauma related guilt in patients with PTSD]. | Various aspects of guilt are frequent problems of patients suffering from PTSD, though they have been included into the diagnostic criteria for PTSD just in the present version DSM-5. Some studies indicate limitation of effectiveness of exposure therapy in PTSD patients with predominant emotions of anger or guilt. The ... | 25,204,104 | [
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[Study on dynamic change law of N, P and K in Panax notoginseng plant soils with different interval year]. | To study effects of different interval year on Panax notoginseng plant soils macro element content. The dynamic change of total N, P, K and available N, P, K in soil from Mabai, Matang, Gumu and Panlong was determined under different planting patterns (new soil, interval 5 years soil and continuous cropping soil). Cont... | 25,204,125 | [
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[Effect of light quality on growth, photosynthesis and effective components of Panax notoginseng]. | In order to discover light quality's effects on growth, photosynthesis and effective components content of Panax notoginseng, a pot experiment using 7 light qualities (red, orange, yellow, green, cyan, violet, and blue) was conducted. The growth, photosynthesis and content change of effective components were measured d... | 25,204,131 | [
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[Comment on applications of data mining used in studies of heritage of experiences of national medical masters]. | Data mining, as known as knowledge discovery in databases, is a non-trivial process of revealing the implied, previously unknown and potentially useful information from the massive data. In recently years, the applications of data mining in the field of pharmaceutical research of traditional Chinese medicine have wides... | 25,204,132 | [
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[Analysis on medication rules of state medical master Yan Zhenghua from prescriptions with citri reticulatae pericarpium based on data mining]. | The prescriptions containing pericarpium citri reticulatae that built by Professor. Yan were collected to build a database based on traditional Chinese medicine (TCM) inheritance assist system. After analyzed by data mining, such as apriori algorithm, the frequency of single medicine, the frequency of drug combination,... | 25,204,133 | [
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[Effects of micronization on micromeritics properties of baicalin]. | Baicalin extremely fine powder was made by using ball-mill and the effect of micronization on the micromeritics properties of baicalin was studied and analyzed. The microstructures of baicalin ordinary and extremely fine powder were compared by scanning electron microscope, differential scanning calorimeter and X-ray d... | 25,204,141 | [
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[Study on supercritical CO2 extraction of xiaoyaosan and its GC-MS fingerprint]. | To determine the optimum conditions of supercritical CO2 extraction of Xiaoyaosan, and establish its fingerprint by gas chromatography-mass spectrometry (GC-MS), the yield of extract were investigated, an orthogonal test was used to quantify the effects of extraction temperature, pressure, CO2 flow rate and time, and f... | 25,204,145 | [
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[Chemical constituents from Glechoma longituba]. | Fourteen compounds were obtained from Glechoma longituba by the chromatographic methods of silica gel, ODS, Sephadex LH-20 and preparative of HPLC. According to physicochemical properties and spectral data, these compounds were identified as stilbostemin B (1), trilepisiumic acid (2), 3, 4-dihydroxyphenyl ethanol keton... | 25,204,149 | [
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[A phytochemical and pharmacological advance on medicinal plant Litsea cubeba (Lauraceae)]. | Litsea cubeba is one of aromatic medicinal plant belonging to family Lauraceae. The roots, stems and fruits of L. cubeba have been widely applied as folk medicines in some districts in China for relieving rheumatism and cold, regulating Qi (meridian) to alleviate pain. Previous studies revealed that this species contai... | 25,204,163 | [
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[Bufadienolides from venom of Bufo bufo gargarizans]. | Twelve compounds were isolated from the venom of Bufo bufo gargarizans. On the basis of their physical and chemical properties and spectral data, their structures were identified as resibufagenin (1), bufotalin (2), desacetylcinobufagin (3), 19-oxodesacetylcinobufotalin (4), cinobufotalin (5), 1beta-hydroxylbufalin (6)... | 25,204,176 | [
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The influence of vapor pressure of chemicals on dermal penetration. | Dermal exposure is an important route of entry for chemicals in occupational and consumer settings. Key to this exposure is the penetration of the skin's barrier, and key to this penetration is a chemical's vapor pressure. Until now, vapor pressure and its effects on the skin have yet to be widely studied. This review ... | 25,204,211 | [
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Textile allergic contact dermatitis: current status. | We conducted a thorough review of Pubmed search results for "textile percutaneous penetration" and "textile absorption". We also determined relevant articles that discussed percutaneous penetration of textiles into the skin and their associated disease states. Due to limitations in current and past publications, we are... | 25,204,213 | [
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Breech delivery in the all fours position: a prospective observational comparative study with classic assistance. | Vaginal delivery of fetal breech presentation is considered to be a challenge for obstetricians. The purpose of this study was to show that vaginal delivery in all fours position is feasible and safe for mother and child compared with vaginal breech and classic support. A single-center prospective observational case se... | 25,204,214 | [
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Predictors of peer victimization among Peruvian adolescents in the young lives cohort. | Bully-victimization is a widespread public health issue with significant negative effects on both social function and psychological well-being. Existing research in Peru shows high prevalence of bullying. However, researchers have yet to fully understand the phenomenon of victimization in developing regions. The purpos... | 25,204,215 | [
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Knowledge and awareness of HIV/AIDS among students of a technical institution. | Acquired immunodeficiency syndrome (AIDS) is a major health problem worldwide. The number of infected people is increasing daily. Knowledge and awareness toward prevention and control of the disease is necessary among both educated and illiterate people. This study is aimed at assessing the knowledge and awareness abou... | 25,204,216 | [
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A core domain of the BMP2 proregion is sufficient for the biogenesis of mature homodimeric growth factor. | The large proregions of cystine knot growth factors exert several important biological functions. Previous results have shown that the proregion of BMP2 retards the activity of the mature growth factor. Hitherto, no information exists about the function of the BMP2 proregion during the biogenesis of the mature growth f... | 25,204,217 | [
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WW domain of BAG3 is required for the induction of autophagy in glioma cells. | Autophagy is an evolutionarily conserved, selective degradation pathway of cellular components that is important for cell homeostasis under healthy and pathologic conditions. Here we demonstrate that an increase in the level of BAG3 results in stimulation of autophagy in glioblastoma cells. BAG3 is a member of a co-cha... | 25,204,229 | [
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Successful isthmo-neovagina anastomosis after Davydov's colpopoiesis in Mayer-Rokitansky-Küster-Hauser syndrome patients with a functional rudimentary uterine horn. | The aim of these case reports is to present the feasibility of isthmo-neovagina anastomosis after Davydov's colpopoiesis in patients with Mayer-Rokitansky-Küster-Hauser syndrome (MRKH) with a rudimentary uterine horn. Ten MRKH patients were treated surgically with laparoscopic Davydov's vaginoplasty between 2006 and 20... | 25,204,254 | [
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Mutation breeding of Saccharomyces cerevisiae with lower methanol content and the effects of pectinase, cellulase and glycine in sugar cane spirits. | To decrease the methanol content of the sugar cane sprits, mutagenesis of ultraviolet (UV) coupled with diethyl sulfate (DES) was used to generate a mutant of Saccharomyces cerevisiae with lower methanol content. Meanwhile, the effects of the additions of pectinase, cellulase and glycine on the production of methanol i... | 25,204,269 | [
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Clinical and radiological long-term outcomes after matrix-induced autologous chondrocyte transplantation: a prospective follow-up at a minimum of 10 years. | It is unclear whether matrix-associated autologous chondrocyte transplantation (MACT) results in objective and subjective clinical improvements at 10 years after surgery. Matrix-associated autologous chondrocyte transplantation will result in clinical and radiological improvements in patients with symptomatic, traumati... | 25,204,296 | [
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Novonestmycins A and B, two new 32-membered bioactive macrolides from Streptomyces phytohabitans HBERC-20821. | Two new 32-membered macrolide compounds, named Novonestmycins A (1) and B (2), were isolated from the soil strain Streptomyces phytohabitans HBERC-20821. Their structures were elucidated by using spectroscopic methods, including 1D, 2D-NMR and MS spectrometry. The two compounds showed strong activities against the phyt... | 25,204,346 | [
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Positive reappraisal in older adults: a systematic literature review. | Positive reappraisal is a meaning-based cognitive emotion regulation strategy that is frequently used by older adults to deal with stressors. The strategy involves finding personally relevant positive meaning from an experience in the face of its negative reality. As positive reappraisal has not been previously systema... | 25,204,368 | [
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Understanding the process of motivational interviewing: A review of the relational and technical hypotheses. | The current study systematically reviews evidence for a causal chain model suggested by Miller and Rose to account for the efficacy of Motivational Interviewing (MI). Literature searches were conducted to identify studies delivering MI in an individual format to treat various problem areas. Thirty-seven studies met inc... | 25,204,407 | [
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Reinforcing Poly(ethylene) with Cellulose Nanocrystals. | The fabrication of nanocomposites of low-density polyethylene (LDPE), one of the world's most widely used polymers, and cellulose nanocrystals (CNCs), which represent the world's most abundant bio-based nanofiller, is reported. While the hydrophobic polymer and the hydrophilic filler seem to be intrinsically incompatib... | 25,204,424 | [
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Isoform-specific SCF(Fbw7) ubiquitination mediates differential regulation of PGC-1α. | The E3 ubiquitin ligase and tumor suppressor SCF(Fbw7) exists as three isoforms that govern the degradation of a host of critical cell regulators, including c-Myc, cyclin E, and PGC-1α. Peroxisome proliferator activated receptor-gamma coactivator 1α (PGC-1α) is a transcriptional coactivator with broad effects on cellul... | 25,204,433 | [
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Extraction optimization of polysaccharides from Chinese rice wine from the Shaoxing region and evaluation of its immunity activities. | Chinese rice wine is well known for its unique flavor and high nutritional value. It is of interest to investigate the functional components of Chinese rice wine and their health benefits. Response surface design of three factors - pH, ethanol concentration and precipitation time - at three levels was utilized to optim... | 25,204,439 | [
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Systemic glucocorticoid therapy: a review of its metabolic and cardiovascular adverse events. | The prevalence of use of long-term systemic glucocorticoid therapy in the general adult population is 1 %. This figure increases to up to 3 % in elderly women. Metabolic (i.e. diabetes mellitus, dyslipidemia, weight gain, lipodystrophy) and cardiovascular (i.e. hypertension, cardiovascular events) adverse events are co... | 25,204,470 | [
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Serum osteoprotegerin in relation to metabolic status, severity, and estimated risk of subsequent coronary heart disease. | Osteoprotegerin (OPG), a key factor in bone remodeling and vascular calcification, has been suggested to be associated with cardiovascular events. This study sought to assess the relationship between plasma OPG, anthropometric, metabolic status, severity and extent of coronary artery calcification, and the two-year rec... | 25,204,474 | [
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Effect of psychological distress on weight concern and weight control behaviors. | Obesity is associated with chronic disorders like coronary artery diseases, metabolic syndrome, cancers, and psychiatric disorders. Stress may contribute to weight gain by disrupting weight concern, and lead to uncontrolled eating behavior. This study aimed to investigate the effects of stress on weight concern and con... | 25,204,476 | [
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Dexmedetomidine reduces pain associated with rocuronium injection without causing a decrease in BIS values: a dose-response study. | To examine whether dexmedetomidine reduces the injection pain of propofol and rocuronium and to investigate whether the decrease in injection pain is associated with the known sedative action of dexmedetomidine. Randomized, double-blind, placebo-controlled clinical comparison study. Patients undergoing general anesthes... | 25,204,507 | [
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VEGF-releasing suture material for enhancement of vascularization: development, in vitro and in vivo study. | As it has been demonstrated that bioactive substances can be delivered locally using coated surgical suture materials, the authors developed a vascular endothelial growth factor (VEGF)-releasing suture material that should promote vascularization and potentially wound healing. In this context, the study focused on the ... | 25,204,522 | [
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Community views about the health and exposure of children living near a coal ash storage site. | Coal ash, a waste product generated from burning coal, is composed of small particles comprised of highly toxic elements. Coal ash particles contain heavy metals such as arsenic, lead, and mercury, as well as polyaromatic hydrocarbons and radioactive elements. Most coal ash is stored in landfills and ponds, often locat... | 25,204,532 | [
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Copper-catalyzed phosphorylation of sp(2) C-H bonds. | The phosphorylation of the ortho C-H bonds in benzamides containing an 8-aminoquinoline moiety as a bidentate directing group with H-phosphonates using copper as a catalyst under mild temperature conditions is described. This method shows high functional group compatibility and selectively gives mono-substituted produc... | 25,204,577 | [
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Fibroblast growth factor-21 and the beneficial effects of long-chain n-3 polyunsaturated fatty acids. | Long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) in the diet protect against insulin resistance and obesity. Fibroblast growth factor-21 (Fgf21) is a hormonal factor released mainly by the liver that has powerful anti-diabetic effects. Here, we tested whether the beneficial metabolic effects of LC n-3 PUFA invo... | 25,204,579 | [
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A new species of Glugea Thélohan, 1891 in the red sea bream Pagrus major (Temminck & Schlegel) (Teleostei: Sparidae) from China. | A new microsporidian species is described from farmed red sea bream Pagrus major (Temminck & Schlegel) (Teleostei: Sparidae). Large numbers of spherical whitish xenomas were observed throughout the visceral organs of the host. Histological examination showed that the microsporidia caused several xenomas that were e... | 25,204,603 | [
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Sequence-defined polymers via orthogonal allyl acrylamide building blocks. | Biological systems have long recognized the importance of macromolecular diversity and have evolved efficient processes for the rapid synthesis of sequence-defined biopolymers. However, achieving sequence control via synthetic methods has proven to be a difficult challenge. Herein we describe efforts to circumvent this... | 25,204,618 | [
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Dramatic mechanistic change in acid-catalyzed arylation of azafulleroids depending on their ambident N/C basicity: formation of cyclopentene centered pentakisadduct. | Azafulleroid, amino-bridged [5,6]-open fullerene, has the ambident N/C basicity of the incorporated enamine moiety. Acid-catalyzed arylation of N-substituted azafulleroids proceeded via two types of initial N/C protonation to perform monoarylation or 1,4-bisarylation for the N-alkyl substituents and shuttlecock-type pe... | 25,204,634 | [
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Influence of B-ring modifications on proton affinity, transmembrane anion transport and anti-cancer properties of synthetic prodigiosenes. | Prodigiosin is the parent compound of the tripyrrolic natural products known as the prodigiosenes. Some of these natural products and their synthetic analogs show anti-cancer, immunosuppressive and antimicrobial actions, amongst other biological activities. One mechanism put forth to explain their biological activity i... | 25,204,645 | [
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'Isotopo' a database application for facile analysis and management of mass isotopomer data. | The composition of stable-isotope labelled isotopologues/isotopomers in metabolic products can be measured by mass spectrometry and supports the analysis of pathways and fluxes. As a prerequisite, the original mass spectra have to be processed, managed and stored to rapidly calculate, analyse and compare isotopomer enr... | 25,204,646 | [
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Mitochondrial alternative oxidase maintains respiration and preserves photosynthetic capacity during moderate drought in Nicotiana tabacum. | The mitochondrial electron transport chain includes an alternative oxidase (AOX) that is hypothesized to aid photosynthetic metabolism, perhaps by acting as an additional electron sink for photogenerated reductant or by dampening the generation of reactive oxygen species. Gas exchange, chlorophyll fluorescence, photosy... | 25,204,647 | [
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Ferromagnetic interactions in Mn3+ based perovskites. | La0.7Sr0.3Mn(3+)0.85Sb(5+)0.15O3 and La0.7Sr0.3Mn(3+)0.8Sb(5+)0.1Ge(4+)0.1O3 compounds with dominantly isovalent Mn3+ ions were studied by neutron powder diffraction and magnetization measurements. The compounds are basically ferromagnetic, with magnetic moments slightly above of 3 μB/Mn. Upon temperature decrease, the... | 25,204,667 | [
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5th National Audit Project (NAP5) on accidental awareness during general anaesthesia: patient experiences, human factors, sedation, consent, and medicolegal issues. | The 5th National Audit Project (NAP5) of the Royal College of Anaesthetists and the Association of Anaesthetists of Great Britain and Ireland into accidental awareness during general anaesthesia (AAGA) yielded data related to psychological aspects from the patient, and the anaesthetist, perspectives; patients' experien... | 25,204,696 | [
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Evaluation of in situ expression of effector and regulatory cytokines, TLR, galectins and matrix metalloproteinases in oral manifestations of paracoccidioidomycosis. | Although the pathophysiology of paracoccidioidomycosis (PCM) is not completely understood, the study of immune response against fungus has provided insight into understanding the natural course of the disease and its clinical manifestations, hence contributing to the development of preventive measures and treatment pro... | 25,204,704 | [
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An orthotopic mouse model of laryngeal squamous cell carcinoma. | This study aimed to create a reliable and reproducible orthotopic mouse model of laryngeal malignancy that recapitulates its biologic behavior, local invasiveness, and spread as seen in patients. Via direct laryngoscopy, human squamous cell carcinoma line FaDu (ATCC HTB-43) was implanted in the larynx (supraglottis and... | 25,204,712 | [
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Use of a Foley catheter balloon as a tool during endoscopic frontal sinus surgery in a resource-poor environment. | This study aimed to evaluate the non-Food and Drug Administration-approved off-label use of a 10F Foley catheter as a tool during endoscopic frontal sinus surgery. A cohort of 40 patients with chronic frontal rhinosinusitis was prospectively evaluated using the Sino-Nasal Outcome Test (SNOT-22), computed tomography (CT... | 25,204,713 | [
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Astrocytes and microglia but not neurons preferentially generate N-terminally truncated Aβ peptides. | The neuropathological hallmarks of Alzheimer's disease include extracellular neuritic plaques and neurofibrillary tangles. The neuritic plaques contain β-amyloid peptides (Aβ peptides) as the major proteinaceous constituent and are surrounded by activated microglia and astrocytes as well as dystrophic neurites. N-termi... | 25,204,716 | [
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Cardiometabolic effects of two coffee blends differing in content for major constituents in overweight adults: a randomized controlled trial. | The hypothesis was tested that coffee types differing in content of major constituents also differ with regard to cardiometabolic effects. Overweight persons (n = 118) were randomized to consume a dark roast [rich in N-methylpyridinium (NMP)] or medium roast (rich in caffeoylquinic acids, trigonelline) coffee blend for... | 25,204,719 | [
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Low abundance of long-tongued pollinators leads to pollen limitation in four specialized hawkmoth-pollinated plants in the Atlantic Rain forest, Brazil. | Long-tubed hawkmoth-pollinated species present some of the most remarkable examples of floral specialization depending exclusively on long-tongued hawkmoths for sexual reproduction. Nonetheless, long-tongued hawkmoths do not rely exclusively on specialized plants as nectar sources, which may limit sexual reproduction t... | 25,204,723 | [
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Intramolecular thioether crosslinking of therapeutic proteins to increase proteolytic stability. | Protein-based pharmaceuticals typically display high selectivity and low toxicity, but are also characterized by low oral availability, mainly because of enzymatic degradation in the gastrointestinal tract and poor permeability across the intestinal wall. One way to increase the proteolytic stability of peptides and pr... | 25,204,725 | [
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Time spent in different types of childcare and children's development at school entry: an Australian longitudinal study. | To investigate whether the total amount of time in childcare through the first 3 years of life was associated with children's receptive vocabulary, externalising and internalising problem behaviours at age 4-5 years, and whether this association varied for different types of childcare. We used data from the prospective... | 25,204,736 | [
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Asymmetric total synthesis of paecilomycin E, 10'-epi-paecilomycin E and 6'-epi-cochliomycin C. | The asymmetric total syntheses of naturally occurring resorcylic acid lactone paecilomycin E and two of its structural congeners have been reported in this article. The major highlight of the synthetic venture is the application of the late stage Mitsunobu macrolactonization method (as it is difficult to achieve the de... | 25,204,742 | [
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Emerging role of hydrogen sulfide in hypertension and related cardiovascular diseases. | Hydrogen sulfide (H2 S) has traditionally been viewed as a highly toxic gas; however, recent studies have implicated H2 S as a third member of the gasotransmitter family, exhibiting properties similar to NO and carbon monoxide. Accumulating evidence has suggested that H2 S influences a wide range of physiological and p... | 25,204,754 | [
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Epilepsy and mental retardation restricted to females: X-linked epileptic infantile encephalopathy of unusual inheritance. | Epilepsy in females with mental retardation (EFMR) is a rare early infantile epileptic encephalopathy (EIEE), phenotypically resembling Dravet syndrome (DS). It is characterised by a variable degree of intellectual deficits and epilepsy. EFMR is caused by heterozygous mutations in the PCDH19 gene (locus Xq22.1) encodin... | 25,204,757 | [
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Electrocatalytic CO2 reduction with a membrane supported manganese catalyst in aqueous solution. | [Mn(bpy)(CO)3Br] cast in a Nafion membrane is an active heterogeneous electrocatalyst with good selectivity for CO2 reduction to CO in neutral aqueous electrolyte. Addition of multi-walled carbon nanotubes (MWCNT) leads to a ∼10 fold current enhancement and stable CO : H2 yields (1 : 2) at -1.4 V vs. Ag/AgCl at pH 7. | 25,204,759 | [
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Baseline predictors of physical activity in a sample of adults with arthritis participating in a self-directed exercise program. | To examine baseline predictors of moderate-to-vigorous intensity physical activity (MVPA) at the 12-week follow-up in a sample of adults with arthritis participating in a self-directed, multicomponent exercise program. Pretest-posttest. Analyses were limited to those randomized to the exercise intervention. Participant... | 25,204,768 | [
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Gluconic acid from biomass fast pyrolysis oils: specialty chemicals from the thermochemical conversion of biomass. | Fast pyrolysis of biomass to produce a bio-oil followed by catalytic upgrading is a widely studied approach for the potential production of fuels from biomass. Because of the complexity of the bio-oil, most upgrading strategies focus on removing oxygen from the entire mixture to produce fuels. Here we report a novel me... | 25,204,798 | [
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Clinico-pathological significance of the molecular alterations of the SPOP gene in prostate cancer. | Speckle-type POZ protein (SPOP) is an E3 ubiquitin ligase adaptor recently described to be mutated in prostate cancer (PCa). Hence, studying the gene expression profile and the presence of SPOP mutations in PCa and understanding its clinico-pathological significance as prognostic and therapeutic biomarker are important... | 25,204,806 | [
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-0.06... |
SERS spectroscopic evidence for the integrity of surface-deposited self-assembled coordination cages. | A series of self-assembled coordination cages [Pd4L(n)8] based on a phenothiazine backbone has been investigated by means of Raman spectroscopy in solution and by Surface Enhanced Raman Scattering (SERS) on a nanostructured Au surface. The experiments demonstrate that the cages can be clearly distinguished from their c... | 25,204,834 | [
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0.03498602,
0.07580872,
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0.1397254,
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The increased detection of cervical intraepithelial neoplasia when using a second biopsy at colposcopy. | It has been suggested that colposcopy can miss a significant percentage of high-grade cervical intraepithelial neoplasia (CIN2+). Improved disease ascertainment was evaluated by taking multiple lesion-directed biopsies. In a cross-sectional multicenter study in the Netherlands and Spain, 610 women referred to colposcop... | 25,204,846 | [
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0.001768531,
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Effects of exercise on BMI z-score in overweight and obese children and adolescents: a systematic review with meta-analysis. | Overweight and obesity are major public health problems in children and adolescents. The purpose of this study was to conduct a systematic review with meta-analysis to determine the effects of exercise (aerobic, strength or both) on body mass index (BMI) z-score in overweight and obese children and adolescents. Studies... | 25,204,857 | [
-0.09335665,
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0.1516104,
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Kinetic inductance magnetometer. | Sensing ultra-low magnetic fields has various applications in the fields of science, medicine and industry. There is a growing need for a sensor that can be operated in ambient environments where magnetic shielding is limited or magnetic field manipulation is involved. To this end, here we demonstrate a new magnetomete... | 25,204,869 | [
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0.04520971,
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0.1015185,
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Antibiotic dosing in critically ill patients receiving CRRT: underdosing is overprevalent. | Published CRRT drug dosing algorithms and other dosing guidelines appear to result in underdosed antibiotics, leading to failure to attain pharmacodynamic targets. High mortality rates persist with inadequate antibiotic therapy as the most important risk factor for death. Reasons for unintended antibiotic underdosing i... | 25,204,875 | [
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Knowledge and extractivism of Stryphnodendron rotundifolium Mart. in a local community of the Brazilian Savanna, Northeastern Brazil. | This study aims to understand how the stem bark of Stryphnodendron rotundifolium Mart. is used by a rural community in the savanna of Northeastern Brazil, associated with a preliminary assessment involving plant population structure and extractivism in the main sites of collection. A population structure study and anal... | 25,204,893 | [
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Gout: clinical presentation and management. | Gout is a painful inflammatory condition that can affect a variety of joints, causes significant distress and is associated with a number of comorbidities. This article aims to dispel the myths surrounding this condition and explore the pathogenesis, clinical presentation, risk factors and diagnosis. It also describes ... | 25,204,952 | [
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We are all individuals... bioinformatics in the personalized medicine era. | The medical landscape is evolving at a rapid pace, creating the opportunity for more personalized patient treatment and shifting the way healthcare is approached and thought about. With the availability of (epi)genome-wide, transcriptomic and proteogenomic profiling techniques detailed characterization of a disease at ... | 25,204,962 | [
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0.02441069,
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Preserved β-cell function in type 1 diabetes by mesenchymal stromal cells. | The retention of endogenous insulin secretion in type 1 diabetes is an attractive clinical goal, which opens possibilities for long-term restoration of glucose metabolism. Mesenchymal stromal cells (MSCs) constitute, based on animal studies, a promising interventional strategy for the disease. This prospective clinical... | 25,204,974 | [
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0.121935,
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Exercise before and during pregnancy prevents the deleterious effects of maternal high-fat feeding on metabolic health of male offspring. | The intrauterine environment during pregnancy is a critical factor in the development of diabetes and obesity in offspring. To determine the effects of maternal exercise during pregnancy on the metabolic health of offspring, 6-week-old C57BL/6 virgin female mice were fed a chow (21%) or high-fat (60%) diet and divided ... | 25,204,976 | [
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0.235094,
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0.3083747,
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Citrullinated glucose-regulated protein 78 is an autoantigen in type 1 diabetes. | Posttranslational modifications of self-proteins play a substantial role in the initiation or propagation of the autoimmune attack in several autoimmune diseases, but their contribution to type 1 diabetes is only recently emerging. In the current study, we demonstrate that inflammatory stress, induced by the cytokines ... | 25,204,978 | [
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0.07568662,
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... |
Pharmacokinetic evaluation of treprostinil (oral) for the treatment of pulmonary arterial hypertension. | This review summarizes current information on the first oral prostanoid approved for treatment of pulmonary arterial hypertension, treprostinil diolamine , which, similar to other prostacyclin analogs, vasodilates, impacts remodeling (antiproliferative), reduces endothelial cell dysfunction, inhibits platelet aggregati... | 25,204,984 | [
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0.05346634,
0.06595185,
0.5518112,
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0.2266483,
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0.... |
Swimming goggle wear is not associated with an increased prevalence of glaucoma. | Previous studies have demonstrated a small but significant transient increase in intraocular pressure (IOP) in individuals wearing certain types of swimming goggles. These findings suggested that wearing goggles could represent a significant risk factor for developing and/or worsening of glaucoma in people who swim reg... | 25,204,989 | [
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0.2579175,
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0.1238981,
... |
Inflammatory monocyte effector mechanisms. | Monocytes are blood-derived mononuclear phagocytic cells that traffic throughout the body and can provide rapid innate immune effector responses in response to microbial pathogen infections. Among blood monocytes, the most abundant subset in mice is represented by inflammatory Ly6C(+) CCR2(+) monocytes and is the funct... | 25,205,002 | [
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0.08084492,
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0.02320695,
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0.02143922,
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0.2126776,
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Risk patterns and correlated brain activities. Multidimensional statistical analysis of FMRI data in economic decision making study. | Decision making usually involves uncertainty and risk. Understanding which parts of the human brain are activated during decisions under risk and which neural processes underly (risky) investment decisions are important goals in neuroeconomics. Here, we analyze functional magnetic resonance imaging (fMRI) data on 17 su... | 25,205,006 | [
0.09495729,
0.1521901,
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0.2992246,
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0.060254... |
A robust rabbit line increases leucocyte counts at weaning and reduces mortality by digestive disorder during fattening. | The present work evaluates how a rabbit line selected for robustness and two other lines selected for productive criteria, could have affected the physiological maturity and blood leukocytes counts of young rabbits at weaning, as well as their possible effect on the subsequent performance and health status during the g... | 25,205,010 | [
0.1888155,
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... |
Paroxysmal kinesigenic dyskinesia and myotonia congenita in the same family: coexistence of a PRRT2 mutation and two CLCN1 mutations. | Paroxysmal kinesigenic dyskinesia (PKD) and myotonia congenita (MC) are independent disorders that share some clinical features. We aimed to investigate the sequences of PRRT2 and CLCN1 in a proband diagnosed with PKD and suspected MC. Clinical evaluation and auxiliary examinations were performed. Direct sequencing of ... | 25,205,014 | [
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0.04591288,
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0.01070382,
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0.2181317,
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Plant genetic identity of foundation tree species and their hybrids affects a litter-dwelling generalist predator. | The effects of plant genetics on predators, especially those not living on the plant itself, are rarely studied and poorly understood. Therefore, we investigated the effect of plant hybridization and genotype on litter-dwelling spiders. Using an 18-year-old cottonwood common garden, we recorded agelenid sheet-web densi... | 25,205,028 | [
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0.3395126,
0.2560608,
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0.2400271,
0.4098688,
-0.205,
-0.... |
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