title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Eimeria tenella: 14-3-3 protein interacts with telomerase. | Telomerase, consisting of telomerase RNA and telomerase reverse transcriptase (TERT), is responsible for the maintenance of the end of linear chromosomes. TERT, as the catalytic subunit of telomerase, plays a critical role in telomerase activity. Researches indicate TERT-associated proteins participate in the regulatio... | 25,216,780 | [
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Is closed suction drainage effective in early recovery of hip joint function? Comparative evaluation in one-stage bilateral total hip arthroplasty. | One-stage primary bilateral cementless total hip arthroplasty with unilateral closed suction drainage (CSD) was prospectively performed for 51 patients (102 hips), and local effects of CSD were quantitatively evaluated. Postoperatively, pain scores evaluated by visual analog scale and periwound temperatures measured by... | 25,216,791 | [
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Light and electron microscopic features of surgically excised left atrial appendage in rheumatic heart disease patients with atrial fibrillation and sinus rhythm. | There are few studies comparing the pathology of the remodeled substrate in patients of rheumatic heart disease with atrial fibrillation (AF) and normal sinus rhythm (NSR). The study group comprised 30 patients with rheumatic heart disease undergoing mitral valve replacement. Excised left atrial appendages of these pat... | 25,216,788 | [
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Social stress and escalated drug self-administration in mice II. Cocaine and dopamine in the nucleus accumbens. | Social defeat stress results in escalation of cocaine taking and long-term neural adaptations in rats. How the intensity and timing of social defeat stress determine these effects, particularly in mice, have not been well characterized. This study investigated the effects of mild vs. moderate intensities and durations ... | 25,216,798 | [
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Optimising the production of succinate and lactate in Escherichia coli using a hybrid of artificial bee colony algorithm and minimisation of metabolic adjustment. | Metabolic engineering is a research field that focuses on the design of models for metabolism, and uses computational procedures to suggest genetic manipulation. It aims to improve the yield of particular chemical or biochemical products. Several traditional metabolic engineering methods are commonly used to increase t... | 25,216,804 | [
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The concentration of carbon monoxide in the breathing areas of workers during logging operations at the motor-manual level. | This article compares 2 variants of logging technologies at the motor-manual level: variant A - cutting and delimbing by means of a petrol chainsaw, skidding with the use of a cable winch mounted on a tractor (67-74 kW); variant B - cutting by means of a petrol chainsaw, skidding, debranching and cutting to length by m... | 25,216,817 | [
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Modelled target attainment after meropenem infusion in patients with severe nosocomial pneumonia: the PROMESSE study. | The objective of this study was to propose an optimal treatment regimen of meropenem in critically ill patients with severe nosocomial pneumonia. Among 55 patients in intensive care treated with 1 g of meropenem every 8 h for severe nosocomial pneumonia, 30 were assigned to intermittent infusion (II; over 0.5 h) and 25... | 25,216,821 | [
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Diffusion-weighted magnetic resonance imaging for non-neoplastic conditions in the hepatobiliary and pancreatic regions: pearls and potential pitfalls in imaging interpretation. | Potentially, diffusion-weighted magnetic resonance imaging (DWI) can assess the functional information on concerning the status of tissue cellularity, because increased cellularity is associated with impeded diffusion. DWI in the hepatobiliary and pancreatic regions has demonstrated the usefulness to detect malignant l... | 25,216,848 | [
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Downregulation of microRNA-100 correlates with tumor progression and poor prognosis in colorectal cancer. | Dysregulation of microRNA-100 (miR-100) has been shown to be involved in cancer tumorigenesis and progression of several cancer types. However, its expression patterns in tumors are controversial. The aim of this study was to investigate the expression and clinical significance of miR-100 in colorectal cancer (CRC). Qu... | 25,216,869 | [
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WWP2: a multifunctional ubiquitin ligase gene. | The ubiquitin-proteasome system plays an important role in various celluar processes. WWP2, a recently identified ubiquitin E3 ligase, has been proved a multifunctional gene by degradation a series of targets via ubiquitin-dependent proteasome system, including PETN, Smads, Oct4, EGR2, TIRF and so. Hereafter, we review... | 25,216,927 | [
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Direct interaction of actin filaments with F-BAR protein pacsin2. | Two mechanisms have emerged as major regulators of membrane shape: BAR domain-containing proteins, which induce invaginations and protrusions, and nuclear promoting factors, which cause generation of branched actin filaments that exert mechanical forces on membranes. While a large body of information exists on interact... | 25,216,944 | [
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Pulse pressure variation is not a valid predictor of fluid responsiveness in patients with elevated left ventricular filling pressure. | The purpose of this study was to test the hypothesis that the predictive ability of pulse pressure variation (PPV) for fluid responsiveness would be altered in patients with elevated left ventricular (LV) filling pressure. According to the preoperative echocardiographic assessment of the ratio of early transmitral flow... | 25,216,949 | [
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Evaluation of the ecotoxicity of pollutants with bioluminescent microorganisms. | This chapter deals with the use of bioluminescent microorganisms in environmental monitoring, particularly in the assessment of the ecotoxicity of pollutants. Toxicity bioassays based on bioluminescent microorganisms are an interesting complement to classical toxicity assays, providing easiness of use, rapid response, ... | 25,216,953 | [
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Rapid in-vitro testing for chemotherapy sensitivity in leukaemia patients. | Bioluminescent bacterial biosensors can be used in a rapid in vitro assay to predict sensitivity to commonly used chemotherapy drugs in acute myeloid leukemia (AML). The nucleoside analog cytarabine (ara-C) is the key agent for treating AML; however, up to 30 % of patients fail to respond to treatment. Screening of pat... | 25,216,956 | [
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Mass-spectrometry-based microbial metabolomics: recent developments and applications. | Metabolomics is an omics technique aiming at qualitatively and quantitatively describing a metabolome by various analytical platforms. It is an indispensable component of modern systems biology. Microbial metabolomics can be roughly classified as metabolic footprint analysis and metabolic fingerprint analysis depending... | 25,216,964 | [
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Spatial point processes and moment dynamics in the life sciences: a parsimonious derivation and some extensions. | Mathematical models of dynamical systems in the life sciences typically assume that biological systems are spatially well mixed (the mean-field assumption). Even spatially explicit differential equation models typically make a local mean-field assumption. In effect, the assumption is that diffusive movement is strong e... | 25,216,969 | [
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A 10-year prospective study of respiratory disease and depression and anxiety in adulthood. | Several cross-sectional studies have found an association between respiratory disease and increased mood or anxiety disorders among adults. Little is known about the nature of these associations over time or the role of potential confounders in these links. To investigate the association between respiratory disease and... | 25,216,970 | [
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Medication errors in ED: Do patient characteristics and the environment influence the nature and frequency of medication errors? | Medication safety is of increasing importance and understanding the nature and frequency of medication errors in the Emergency Department (ED) will assist in tailoring interventions which will make patient care safer. The challenge with the literature to date is the wide variability in the frequency of errors reported ... | 25,216,984 | [
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Calcifying fibrous pseudotumour of the tongue: report of a rare case. | We describe a rare case of calcifying fibrous pseudotumour of the tongue in a 33-year-old woman. | 25,216,986 | [
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Climate change and land management in the rangelands of central Oregon. | Climate change, along with exotic species, disturbances, and land use change, will likely have major impacts on sagebrush steppe ecosystems in the western U.S. over the next century. To effectively manage sagebrush steppe landscapes for long-term goals, managers need information about the interacting impacts of climate... | 25,216,989 | [
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Improving survival and growth of planted Austrocedrus chilensis seedlings in disturbed patagonian forests of Argentina by managing understory vegetation. | This study was aimed at determining, under field conditions, early interactions between planted cypress seedlings and their associated shrubs in a mesic area of Andean Patagonia and, in a nursery, the effects of increasing light availability on cypress performance when soil water was not a limiting factor. The field ex... | 25,216,990 | [
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Hemicrania continua: major shortcomings in the new classification. | Hemicrania continua ( HC) was described and coined by Sjaastad and Spierings in 1984. Later cases, carrying this appellation should, grossly, conform to this original description. The proposed classification criteria (ICHD, 3rd edition beta version) for HC has major shortcomings, and ordinary HC cases do not fulfill th... | 25,216,994 | [
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[Clinical relevance of the K-ras oncogene in colorectal cancer: experience in a Mexican population]. | Colorectal cancer is frequent in the developed countries, with a cancer-specific mortality rate of 33%. Different biomarkers are associated with overall survival and the prediction of monoclonal treatment effectiveness. The presence of mutations in the K-ras oncogene alters the response to target therapy with cetuximab... | 25,216,999 | [
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Effects of Nicotine on Streptococcus gordonii Growth, Biofilm Formation, and Cell Aggregation. | Streptococcus gordonii is a commensal species of human oral flora. It initiates dental biofilm formation and provides binding sites for later colonizers to attach to and generate mature biofilm. Smoking is the second highest risk factor for periodontal disease, and cigarette smoke extract has been reported to facilitat... | 25,217,021 | [
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Therapeutic window for striatal dopamine D(2/3) receptor occupancy in older patients with schizophrenia: a pilot PET study. | In younger patients with schizophrenia, positron emission tomography (PET) studies have identified a therapeutic window of striatal dopamine D(2/3) receptor occupancy of 65%-80%. This type of empirical information is not available in late life. Our primary aim was to assess the effect of changes in D(2/3) relative rece... | 25,217,025 | [
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Diet shift induced rapid evolution of size and function in a predatory bird. | A predator's body size correlates with its prey size. Change in the diet may call for changes in the hunting mode and traits determining hunting success. We explored long-term trends in sternum size and shape in the northern goshawk by applying geometric morphometrics. Tetraonids, the primary prey of the goshawk, have ... | 25,217,047 | [
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Why brain death is considered death and why there should be no confusion. | Neurologic determination of brain death is a complex assessment that may be misunderstood by nonspecialists and families. Recent guidelines clarify how to proceed with such an examination and are available to physicians, with the time of death in adults and children being determined by the last defining test-the apnea ... | 25,217,058 | [
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Effect of femtosecond laser-assisted cataract surgery on the corneal endothelium. | To compare the effect on the corneal endothelium of femtosecond laser-assisted cataract surgery and conventional phacoemulsification cataract surgery. Private clinic, Tasmania, Australia. Prospective comparative cohort study. Femtosecond laser-assisted cataract surgery (study group) or conventional phacoemulsification ... | 25,217,072 | [
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0.1070654,
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... |
Analysis of selected risk factors for nodal metastases in head and neck cutaneous squamous cell carcinoma. | Cutaneous squamous cell carcinoma (cSCC) accounts for 20% of all skin malignancies and 20% of deaths. In contrast to mucosal SCC, treatment results are very good. However, regional metastases are present in 5-20% of cases, and the prognosis for patients with metastases is 50% lower. It has been reported that several ri... | 25,217,080 | [
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Intratympanic steroids as a salvage treatment for sudden sensorineural hearing loss? A meta-analysis. | Sudden sensorineural hearing loss is typically treated with systemic steroids. The aim of this meta-analysis was to evaluate the efficacy of salvage intratympanic steroid treatment in patients who have initial treatment failure with systemic steroids. A MEDLINE literature search was performed, supported by searches of ... | 25,217,083 | [
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[Successful treatment of Bowen disease with ingenol mebutate]. | Ingenol mebutate is a novel cytotoxic drug extracted from the plant Euphorbia peplus. Since November 2012 it is approved in Germany for the treatment of superficial actinic keratoses. We report the successful treatment of Bowen disease with ingenol mebutate in a patient being treated with the multikinase inhibitor suni... | 25,217,087 | [
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Editorial: ASD and illegal behaviors. | The last decade has seen significant advances in our understanding of autism spectrum disorder, from both biological and clinical perspectives. Outcome runs the gamut from complete independence to relative dependence. Of particular interest, among those described with poor outcome are a small number of individuals, mal... | 25,217,089 | [
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Single-incision versus conventional multiport laparoscopic colorectal surgery-systematic review and pooled analysis. | The aim of this pooled analysis is to determine the effect of single-incision laparoscopic colorectal surgery (SILC) on short-term clinical and oncological outcomes compared with conventional multiport laparoscopic colorectal surgery (CLC). An electronic search of Embase, Medline, Web of Science, and Cochrane databases... | 25,217,093 | [
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Sutured repair of primary small umbilical and epigastric hernias: concomitant rectus diastasis is a significant risk factor for recurrence. | Umbilical and epigastric hernias are common in the adult population and prompt repair is advised. We aimed to evaluate the impact of concomitant rectus diastasis on the outcome of patients who underwent primary sutured fascia closure of a hernia without mesh. We performed a retrospective analysis of 231 consecutive adu... | 25,217,109 | [
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Chondromyxoid fibroma management: a single institution experience of 22 cases. | Several different strategies have been reported for the treatment of chondromyxoid fibromas, all with variable outcomes and high recurrence rates. We report on 22 consecutive cases of chondromyxoid fibromas treated by intralesional curettage, four of which had adjuvant cementation at our institution between 2003 and 20... | 25,217,119 | [
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Predictors for mortality following acute pancreatitis in children. | Although there are several studies focusing on pancreatitis etiology and clinical outcome, no previous report has examined the risk factors for death in children. We reviewed the medical records of all children (ages 0-18 years) admitted to West China Hospital with acute pancreatitis between 2002 and 2012. Independent ... | 25,217,139 | [
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The area and attachment abnormalities of the gubernaculum in patients with undescended testes in comparison with those with retractile testes. | In order to evaluate the gubernaculum (GN) abnormalities quantitatively in patients with undescended testes (UDT), the area and attachment site of the gubernaculum were evaluated. Sixty-seven testes from 61 patients with an undescended testis treated in the past 11 years at our institution were examined. Using intraope... | 25,217,140 | [
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The Affordable Care Act, health care reform, prescription drug formularies and utilization management tools. | The U.S. Patient Protection and Affordable Care Act (hence, Affordable Care Act, or ACA) was signed into law on March 23, 2010. Goals of the ACA include decreasing the number of uninsured people, controlling cost and spending on health care, increasing the quality of care provided, and increasing insurance coverage ben... | 25,217,142 | [
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Prevalence, incidence, clearance, and associated factors of genital human papillomavirus infection among men: a population-based cohort study in rural China. | The natural history of human papillomavirus (HPV) infection in men on a population base has rarely been studied in general, particularly among Chinese men. A total of 1,286 men ages 25 to 65 years from rural China were enrolled during 2009-2010 and their genital HPV infection status was assessed biannually for up to se... | 25,217,154 | [
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TRAIL-receptor costimulation inhibits proximal TCR signaling and suppresses human T cell activation and proliferation. | The TRAIL-receptor/TRAIL system originally described to induce apoptosis preferentially in malignant cells is also known to be involved in T cell homeostasis and the response to viral infections and autoimmune diseases. Whereas the expression of TRAIL on activated NK and T cells increases their cytotoxicity, induction ... | 25,217,163 | [
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Aging delays resolution of acute inflammation in mice: reprogramming the host response with novel nano-proresolving medicines. | Aging is associated with an overt inflammatory phenotype and physiological decline. Specialized proresolving lipid mediators (SPMs) are endogenous autacoids that actively promote resolution of inflammation. In this study, we investigated resolution of acute inflammation in aging and the roles of SPMs. Using a self-reso... | 25,217,168 | [
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White matter microstructure and cognition in adolescents with congenital heart disease. | To describe the relationship between altered white matter microstructure and neurodevelopment in children with dextro-transposition of the great arteries (d-TGA). We report correlations between regional white matter microstructure as measured by fractional anisotropy (FA) and cognitive outcome in a homogeneous group of... | 25,217,200 | [
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All-cause mortality and cardiovascular events with nicorandil in patients with IHD: systematic review and meta-analysis of the literature. | Nicorandil is able to protect the cardiomyocytes from ischemic damage, but clear benefits of nicorandil in all-cause mortality and cardiovascular events were not consistently reported in patients with ischemic heart disease (IHD). Cochrane, PubMed, EMBASE, CBM, CNKI and Wangfang databases were searched for randomized c... | 25,217,220 | [
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Cathepsin B is involved in the heat shock induced cardiomyocytes apoptosis as well as the anti-apoptosis effect of HSP-70. | Cathepsin B is one of the major lysosomal cysteine proteases that plays an important role in apoptosis. Herein, we investigated whether Cathepsin B is involved in cardiomyocyte apoptosis caused by hyperthermic injury (HI) and heat shock protein (HSP)-70 protects these cells from HI-induced apoptosis mediated by Catheps... | 25,217,222 | [
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The p53 control of apoptosis and proliferation: lessons from Drosophila. | The canonical role of p53 in preserving genome integrity and limiting carcinogenesis has been well established. In the presence of acute DNA-damage, oncogene deregulation and other forms of cellular stress, p53 orchestrates a myriad of pleiotropic processes to repair cellular damages and maintain homeostasis. Beside th... | 25,217,223 | [
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Prognostic impact of intraocular involvement in primary CNS lymphoma: experience from the G-PCNSL-SG1 trial. | The impact of intraocular involvement (IOL) in primary CNS lymphoma (PCNSL) has not been sufficiently evaluated. Here, we present the analysis of IOL in the only completed randomized phase III trial in PCNSL. The G-PCNSL-SG1 study evaluated the role of whole-brain radiotherapy in primary therapy of PCNSL. Data of the 5... | 25,217,230 | [
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Disease control for patients with psoriasis receiving continuous versus interrupted therapy with adalimumab or etanercept: a clinical practice study. | Studies analyzing the efficacy and safety of interrupted psoriasis therapy with biologic drugs have not reported clear benefits in routine clinical practice. To identify differences in the disease control of psoriasis patients undergoing continuous or interrupted therapy with adalimumab or etanercept. This retrospectiv... | 25,217,234 | [
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Progenitor cells and podocyte regeneration. | The very limited ability of adult podocytes to proliferate in vivo is clinically significant because podocytes form a vascular barrier that is functionally critical to the nephron, podocyte hypoplasia is a characteristic of disease, and inadequate regeneration of podocytes is a major cause of persistent podocyte hypopl... | 25,217,270 | [
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Large-scale monitoring and assessment of metal contamination in surface water of the Selenga River Basin (2007-2009). | An extensive and year-round survey was conducted to assess metal pollution in vast watershed areas of the Selenga River Basin (2007-2009), which provided baseline heavy metal database for the future management. Sources and environmental hazard and risk indices associated with metal pollution were evidenced across the c... | 25,217,283 | [
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Ghrelin negatively affects the function of ovarian follicles in mature pigs by direct action on basal and gonadotropin-stimulated steroidogenesis. | We previously showed that expression of ghrelin messenger RNA is significantly increased in the ovaries of cycling pigs but not in prepubertal animals and that ghrelin stimulates estradiol (E2) secretion by ovarian follicles in prepubertal animals. The present study investigated in vitro the role of ghrelin in regulati... | 25,217,306 | [
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Population data of 15 autosomal STR markers from Afro-Bolivians of Nor Yungas Province (Bolivia). | Allele frequencies and forensic parameters for 15 autosomal loci included in the AmpFlSTR® Identifiler kit were estimated in a sample of 57 unrelated Afro-descendants from Nor Yungas (Bolivia). Buccal swabs samples were obtained from voluntary donors, after consent was given. All loci were in Hardy-Weinberg equilibrium... | 25,217,341 | [
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Fiscal incentives, behavior change and health promotion: what place in the health-in-all-policies toolkit? | Taxes, subsidies and welfare benefits may provide financial incentives to encourage healthy behaviors or discourage less healthy ones. Historically, taxes have been used in many countries to deter behaviors like tobacco smoking or harmful alcohol use. More recently, an increasing number of governments have sought to ex... | 25,217,345 | [
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Evaluation of Health in All Policies: concept, theory and application. | This article describes some of the crucial theoretical, methodological and practical issues that need to be considered when evaluating Health in All Policies (HiAP) initiatives. The approaches that have been applied to evaluate HiAP in South Australia are drawn upon as case studies, and early findings from this evaluat... | 25,217,350 | [
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Impact of hypocapnia and cerebral perfusion on orthostatic tolerance. | We examined two novel hypotheses: (1) that orthostatic tolerance (OT) would be prolonged when hyperventilatory-induced hypocapnia (and hence cerebral hypoperfusion) was prevented; and (2) that pharmacological reductions in cerebral blood flow (CBF) at baseline would lower the 'CBF reserve', and ultimately reduce OT. In... | 25,217,373 | [
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Single unit hyperactivity and bursting in the auditory thalamus of awake rats directly correlates with behavioural evidence of tinnitus. | Tinnitus is an auditory percept without an environmental acoustic correlate. Contemporary tinnitus models hypothesize tinnitus to be a consequence of maladaptive plasticity-induced disturbance of excitation-inhibition homeostasis, possibly convergent on medial geniculate body (MGB, auditory thalamus) and related neuron... | 25,217,380 | [
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Delayed anemia assessment in patients treated with oral artemisinin derivatives for uncomplicated malaria: a pooled analysis of clinical trials data from Mali. | In sub-Saharan Africa, artemisinin-based combination therapy (ACT) and injectable artesunate are the first-line treatments for uncomplicated and severe Plasmodium falciparum malaria, respectively. However, recent studies suggest that delayed anaemia is associated with these treatments in non-immune travellers. This pap... | 25,217,396 | [
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Progression to multi-scale models and the application to food system intervention strategies. | The aim of this article is to discuss how the systems science approach can be used to optimize intervention strategies in food animal systems. It advocates the idea that the challenges of maintaining a safe food supply are best addressed by integrating modeling and mathematics with biological studies critical to formul... | 25,217,407 | [
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Raman spectroscopy for a rapid diagnosis of sickle cell disease in human blood samples: a preliminary study. | Raman spectroscopy has been proposed as a tool for diagnosis of human blood diseases aiming a quick and accurate diagnosis. Sickle cell disease arises in infancy and causes a severe anemia; thus, an early diagnosis may avoid pathological complications such as vasoocclusion, hemolytic anemia, retinopathy, cardiovascular... | 25,217,409 | [
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Vitritis in pediatric genetic retinal disorders. | To determine which types of pediatric retinal degeneration are associated with inflammatory cells in the anterior vitreous. Retrospective, observational study in humans. Retrospective chart review was performed for pediatric patients with suspected retinal degeneration presenting to a single examiner from 2008 to 2013.... | 25,217,415 | [
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Propensity-weighted long-term risk of urinary adverse events after prostate cancer surgery, radiation, or both. | Prostate cancer is the second most common cancer in men and has high survivorship, yet little is known about the long-term risk of urinary adverse events (UAEs) after treatment. To compare the long-term UAE incidence across treatment and control groups. Using a matched-cohort design, we identified elderly men treated w... | 25,217,421 | [
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Management strategies for heart failure with preserved ejection fraction. | The management of heart failure with preserved ejection fraction (HFpEF) is challenging and requires an accurate diagnosis. Although currently there is no convincing therapy that prolongs survival in patients with HFpEF, treatment of fluid retention and of comorbidities, such as hypertension, myocardial ischemia, and a... | 25,217,434 | [
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Why do they keep coming back? Psychosocial etiology of persistence of frequent attendance in primary care: a prospective cohort study. | Patients who visit their General Practitioner (GP) very frequently over extended periods of time often have multimorbidity and are costly in primary and specialist healthcare. We investigated the impact of patient-level psychosocial and GP-level factors on the persistence of frequent attendance (FA) in primary care. Tw... | 25,217,448 | [
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Isoprenoid biosynthesis in Plasmodium falciparum. | Malaria kills nearly 1 million people each year, and the protozoan parasite Plasmodium falciparum has become increasingly resistant to current therapies. Isoprenoid synthesis via the methylerythritol phosphate (MEP) pathway represents an attractive target for the development of new antimalarials. The phosphonic acid an... | 25,217,461 | [
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Surviving catastrophic disintegration of a large left atrial myxoma: the importance of multi-disciplinary team. | Atrial myxomas are the most common primary cardiac tumors, representing ∼50% of all benign cardiac tumors. Patients with a left atrial myxoma (LAM) generally present with symptoms of mechanical obstruction of blood flow, systemic emboli or constitutional symptoms. Embolic complications may occur any time with progressi... | 25,217,477 | [
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Evidence that environmental and genetic risks for psychotic disorder may operate by impacting on connections between core symptoms of perceptual alteration and delusional ideation. | Relational models of psychopathology propose that symptoms are dynamically connected and hypothesize that genetic and environmental influences moderate the strength of these symptom connections. Previous findings suggest that the interplay between hallucinations and delusions may play a crucial role in the development ... | 25,217,481 | [
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Transcatheter aortic valve implantation combined with elective coronary artery stenting: a simultaneous approach†. | Many patients referred for transcatheter aortic valve implantation (TAVI) also require percutaneous coronary intervention (PCI). The aim of the study was to identify whether combined treatment of patients with aortic stenosis and coronary artery disease (CAD) with TAVI and PCI has comparable results to treatment of pat... | 25,217,500 | [
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The Notch pathway inhibits TGFβ signaling in breast cancer through HEYL-mediated crosstalk. | Acquired resistance to TGFβ is a key step in the early stages of tumorigenesis. Mutations in TGFβ signaling components are rare, and little is known about the development of resistance in breast cancer. On the other hand, an activated Notch pathway is known to play a substantial role in promoting breast cancer developm... | 25,217,524 | [
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Evaluation of laser diode thermal desorption-tandem mass spectrometry (LDTD-MS-MS) in forensic toxicology. | Many forensic laboratories experience backlogs due to increased drug-related cases. Laser diode thermal desorption (LDTD) has demonstrated its applicability in other scientific areas by providing data comparable with instrumentation, such as liquid chromatography-tandem mass spectrometry, in less time. LDTD-MS-MS was u... | 25,217,542 | [
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Equine total carbon dioxide testing in Illinois in 2012. | During prolonged strenuous exercise, racehorses can experience acidemia. To counteract this phenomenon, trainers can administer blood alkalizing agents that raise the plasma pH and total carbon dioxide (TCO2) concentration. In Illinois, the administrative threshold for TCO2 in plasma is 37.0 mmol/L. Because accuracy in... | 25,217,543 | [
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XLR-11 and UR-144 in Washington state and state of Alaska driving cases. | The case reports for 18 driving cases positive for the synthetic cannabinoid substances XLR-11 and/or UR-144 are discussed. Eleven of these cases had drug recognition expert evaluations performed. Slurred speech, lack of convergence and body and eyelid tremors were the most consistently noted interview characteristic. ... | 25,217,547 | [
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Improved rat genome gene prediction by integration of ESTs with RNA-Seq information. | RNA-Seq (also called whole-transcriptome sequencing) is an emerging technology that uses the capabilities of next-generation sequencing to detect and quantify entire transcripts. One of its important applications is the improvement of existing genome annotations. RNA-Seq provides rapid, comprehensive and cost-effective... | 25,217,576 | [
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The role of microRNAs in the control of innate immune response in cancer. | Ligands for receptors of natural killer (NK) cells and CD8(+) cytotoxic T lymphocytes (CTL), such as the inhibitory nonclassical HLA-G, the activating stress-induced major histocompatibility complex class I-related antigens MICA and MICB, and/or the UL16-binding proteins (ULBPs), are often aberrantly expressed upon vir... | 25,217,579 | [
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The RIG-I ATPase core has evolved a functional requirement for allosteric stabilization by the Pincer domain. | Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor expressed in metazoan cells that is responsible for eliciting the production of type I interferons and pro-inflammatory cytokines upon detection of intracellular, non-self RNA. Structural studies of RIG-I have identified a novel Pincer domain comp... | 25,217,590 | [
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Regulation of retinal oxygen metabolism in humans during graded hypoxia. | Animal experiments indicate that the inner retina keeps its oxygen extraction constant despite systemic hypoxia. For the human retina no such data exist. In the present study we hypothesized that systemic hypoxia does not alter inner retinal oxygen extraction. To test this hypothesis we included 30 healthy male and fem... | 25,217,648 | [
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Oxidative stress associated with middle aging leads to sympathetic hyperactivity and downregulation of soluble guanylyl cyclase in corpus cavernosum. | Impairment of nitric oxide (NO)-mediated cavernosal relaxations in middle age contributes to erectile dysfunction. However, little information is available about the alterations of sympathetic neurotransmission and contraction in erectile tissue at middle age. This study aimed to evaluate the alterations of the contrac... | 25,217,652 | [
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MicroRNA-146a and microRNA-146b expression and anti-inflammatory function in human airway smooth muscle. | MicroRNA (miR)-146a and miR-146b are negative regulators of inflammatory gene expression in lung fibroblasts, epithelial cells, monocytes, and endothelial cells. The abundance of cyclooxygenase-2 (COX-2) and IL-1β is negatively regulated by the miR-146 family, suggesting miR-146a and/or miR-146b might modulate inflamma... | 25,217,662 | [
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Is it safe to use inhaled corticosteroids in pregnancy? | A healthy woman with mild to moderate asthma came to my clinic today after learning that she was pregnant. She inquired about continuing her inhaled corticosteroid (ICS) medication and whether there would be any risks to her unborn child if she were to do so. What would you advise? Given the published evidence, ICSs sh... | 25,217,675 | [
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JAK2V617F+ myeloproliferative neoplasm clones evoke paracrine DNA damage to adjacent normal cells through secretion of lipocalin-2. | Genetic instability is strongly involved in cancer development and progression, and elucidating the mechanism could lead to novel therapeutics for preventing carcinogenesis. Philadelphia-negative myeloproliferative neoplasms (MPNs) are clonal myeloid disorders with a high prevalence of JAK2V617F mutation, and transform... | 25,217,696 | [
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Complete debromination of decabromodiphenyl ether using the integration of Dehalococcoides sp. strain CBDB1 and zero-valent iron. | This study investigated the effects of nano- and micro-scale zero-valent iron (nZVI and mZVI) particles on Dehalococcoides sp. strain CBDB1 participating in anaerobic reduction of polybrominated diphenyl ethers. nZVI (>0.25 g L(-)(1)) had an inhibitory effect upon this strain, whereas 1.0 g L(-1) mZVI showed no nega... | 25,217,713 | [
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Integration of RAFT polymerization and click chemistry to fabricate PAMPS modified macroporous polypropylene membrane for protein fouling mitigation. | A copper (I)-catalyzed azide-alkyne cycloaddition (CuAAC) grafting-to method was used to tether alkyne-terminated poly(2-acrylamido-2-methyl propane sulfonic acid) (alkyne-PAMPS) to the azide functionalized macroporous polypropylene membrane (MPPM-N3). Alkyne-PAMPS was synthesized by the reversible addition-fragmentati... | 25,217,729 | [
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Does maternal intrapartum antibiotic treatment prolong the incubation time required for blood cultures to become positive for infants with early-onset sepsis? | We hypothesized that maternal intrapartum antibiotic treatment delays the growth of the organism in the blood culture obtained during the work-up for infants with suspected early-onset sepsis (EOS). Single center, retrospective review of infants with blood culture-proven EOS over 13.5 years period. EOS was defined by i... | 25,217,736 | [
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Cover crops influence soil microorganisms and phytoextraction of copper from a moderately contaminated vineyard. | We investigated the ability of summer (Avena sativa [oat], Trifolium incarnatum [crimson clover], Chenopodium [goosefoot]) and winter (Vicia villosa [hairy vetch], Secale Cereale L. [Rye], Brassica napus L. partim [rape]) cover crops, including a mixed species treatment, to extract copper from an organic vineyard soil ... | 25,217,742 | [
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Field study on the impact of nocturnal road traffic noise on sleep: the importance of in- and outdoor noise assessment, the bedroom location and nighttime noise disturbances. | The aim of this field study is to gain more insight into the way nocturnal road traffic noise impacts the sleep of inhabitants living in noisy regions, by taking into account several modifying variables. Participants were tested during five consecutive nights in their homes and comparisons between effective indoor and ... | 25,217,747 | [
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... |
Occurrence of phthalate esters in river sediments in areas with different land use patterns. | Phthalate esters (PAEs) are widely used as plasticizers in both industrial and commercial products and have aroused considerable concern over their widespread distribution and potentially hazardous impacts on the environment. The present study investigated the distribution (concentrations at different sites) of PAEs in... | 25,217,750 | [
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... |
Dynamic mass balance model for mercury in the St. Lawrence River near Cornwall, Ontario, Canada. | A dynamic mass balance model was developed for the St. Lawrence River near Cornwall, Ontario that predicts and hindcasts mercury concentrations and fluxes in three forms, elemental Hg (Hg(0)), divalent mercury (Hg(2+)), and methyl mercury (MeHg), in a six compartment environment (air, water, porewater, sediment, periph... | 25,217,751 | [
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0.187184... |
How "lucky" we are that the Fukushima disaster occurred in early spring: predictions on the contamination levels from various fission products released from the accident and updates on the risk assessment for solid and thyroid cancers. | The present paper studies how a random event (earthquake) and the subsequent disaster in Japan affect transport and deposition of fallout and the resulting health consequences. Therefore, except for the original accident in March 2011, three additional scenarios are assessed assuming that the same releases took place i... | 25,217,754 | [
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The new sulfated O-specific polysaccharide from marine bacterium Cobetia pacifica KMM 3878, containing 3,4-O-[(S)-1-carboxyethylidene]-D-galactose and 2,3-O-disulfate-D-galactose. | The O-specific polysaccharide was isolated from the lipopolysaccharide of Cobetia pacifica KMM 3878 and studied by chemical methods along with (1)H and (13)C NMR spectroscopy, including, 1D TOCSY and 2D (1)H, (1)H COSY, (1)H, (13)C HSQC, (1)H, (1)H ROESY, (1)H, (13)C HMBC and (1)H, (13)C H2BC experiments. The following... | 25,217,756 | [
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Development of a risk-screening tool for cancer survivors to participate in unsupervised moderate- to vigorous-intensity exercise: results from a survey study. | The health benefits of exercise increase in dose-response fashion among cancer survivors. However, it is unclear how to identify cancer survivors who may require a pre-exercise evaluation before they progress from the common recommendation of walking to unsupervised moderate- to vigorous-intensity exercise. To clarify ... | 25,217,819 | [
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... |
Peripheral myopization and visual performance with experimental rigid gas permeable and soft contact lens design. | To evaluate the performance of two experimental contact lenses (CL) designed to induce relative peripheral myopic defocus in myopic eyes. Ten right eyes of 10 subjects were fitted with three different CL: a soft experimental lens (ExpSCL), a rigid gas permeable experimental lens (ExpRGP) and a standard RGP lens made of... | 25,217,826 | [
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The great divide: septation and malformation of the cloaca, and its implications for surgeons. | The anorectal and urogenital systems arise from a common embryonic structure termed cloaca. Subsequent development leads to the division/septation of the cloaca into the urethra, urinary bladder, vagina, anal canal, and rectum. Defective cloacal development and the resulting anorectal and urogenital malformations are s... | 25,217,828 | [
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Small nucleolar RNA 113-1 suppresses tumorigenesis in hepatocellular carcinoma. | Emerging evidence suggests that small nucleolar RNAs (snoRNAs) are involved in tumorigenesis. The roles of small nucleolar RNA 113-1 (SNORD113-1) on the development of hepatocellular carcinoma (HCC) remain unknown. The expression of SNORD113-1 was measured in 112 HCC tumor tissues using quantitative RT-PCR and compared... | 25,217,841 | [
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Female cystic fibrosis mutation carriers and assisted reproductive technology: does carrier status affect reproductive outcomes? | To evaluate the association between female cystic fibrosis (CF) carrier status and in vitro fertilization (IVF) response and outcomes. The presence of cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in male carriers has been associated with infertility, yet possible adverse effects on the ovar... | 25,217,870 | [
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A case of right renal artery originating from the thoracic aorta. | The renal arteries normally originate from the abdominal aorta between the first and second lumbar vertebrae. The main renal artery arising from the thoracic aorta is an uncommon anomaly. Here we report a rare case of a right renal artery originating above the celiac axis. A 38-year-old male underwent computed tomograp... | 25,217,879 | [
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... |
Communication: Low-temperature approximation of the virial series for the Lennard-Jones and modified Lennard-Jones models. | The regularity of the existing data on the virial coefficients for the Lennard-Jones and modified Lennard-Jones models has allowed a rough extrapolation to the coefficients of higher orders. The corresponding approximation of the infinite virial series has been proposed for the limited temperature interval: 0.4-0.8 of ... | 25,217,895 | [
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... |
Analytic first derivatives for a spin-adapted open-shell coupled cluster theory: evaluation of first-order electrical properties. | An analytic scheme is presented for the evaluation of first derivatives of the energy for a unitary group based spin-adapted coupled cluster (CC) theory, namely, the combinatoric open-shell CC (COSCC) approach within the singles and doubles approximation. The widely used Lagrange multiplier approach is employed for the... | 25,217,899 | [
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-0.000... |
Testing time-dependent density functional theory with depopulated molecular orbitals for predicting electronic excitation energies of valence, Rydberg, and charge-transfer states and potential energies near a conical intersection. | Kohn-Sham (KS) time-dependent density functional theory (TDDFT) with most exchange-correlation functionals is well known to systematically underestimate the excitation energies of Rydberg and charge-transfer excited states of atomic and molecular systems. To improve the description of Rydberg states within the KS TDDFT... | 25,217,903 | [
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0... |
On the full exploitation of symmetry in periodic (as well as molecular) self-consistent-field ab initio calculations. | Use of symmetry can dramatically reduce the computational cost (running time and memory allocation) of self-consistent-field ab initio calculations for molecular and crystalline systems. Crucial for running time is symmetry exploitation in the evaluation of one- and two-electron integrals, diagonalization of the Fock m... | 25,217,905 | [
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A new ab initio potential energy surface and infrared spectra for the Ar-CS₂ complex. | We report a new three-dimensional potential energy surface for Ar-CS2 involving the Q3 normal mode for the υ3 antisymmetric stretching vibration of the CS2 molecule. The potential energies were calculated using the supermolecular method at the coupled-cluster singles and doubles level with noniterative inclusion of con... | 25,217,915 | [
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Detailed mechanism of the CH₂I + O₂ reaction: yield and self-reaction of the simplest Criegee intermediate CH₂OO. | The application of a new reaction scheme using CH2I + O2 to generate the simplest Criegee intermediate, CH2OO, has stimulated lively research; the Criegee intermediates are extremely important in atmospheric chemistry. The detailed mechanism of CH2I + O2 is hence important in understanding kinetics involving CH2OO. We ... | 25,217,917 | [
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A diabatic state model for double proton transfer in hydrogen bonded complexes. | Four diabatic states are used to construct a simple model for double proton transfer in hydrogen bonded complexes. Key parameters in the model are the proton donor-acceptor separation R and the ratio, D1/D2, between the proton affinity of a donor with one and two protons. Depending on the values of these two parameters... | 25,217,923 | [
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