title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Comparative study of cost of care of outpatients with bipolar disorder and schizophrenia. | To assess and compare the average annual the cost of illness of outpatients with bipolar disorder and schizophrenia. Cost of illness in 75 out-patients with bipolar disorder and 53 out-patients with schizophrenia was assessed over a 9-month period by using bottom-up approach. The cost of 9 months was annualized by divi... | 25,246,322 | [
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Preliminary study of Huai Qi Huang granules delay the development of primary glomerular diseases in human. | To evaluate the effects of Huai Qi Huang (HQH) granules on primary glomerulonephritis patients, and to discuss its possible mechanisms. Sixteen patients diagnosed with primary glomerular disease between December 2011 and December 2012 were enrolled. Their blood and urine samples were collected at day 0 (the baseline le... | 25,246,341 | [
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Seasonal immune modulation in humans: observed patterns and potential environmental drivers. | Cyclical fluctuations in host immunity have been proposed as a driver of respiratory infection seasonality, however few studies have attempted to directly assess whether or not seasonal immune modulation occurs in humans. We reviewed studies assessing immune status at different times of the year, restricting our review... | 25,246,360 | [
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Locking plate fixation provides superior fixation of humerus split type greater tuberosity fractures than tension bands and double row suture bridges. | This paper aims to determine the strongest fixation method for split type greater tuberosity fractures of the proximal humerus by testing and comparing three fixation methods: a tension band with No. 2 wire suture, a double-row suture bridge with suture anchors, and a manually contoured calcaneal locking plate. Each me... | 25,246,375 | [
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Epigenetic modifiers of islet function and mass. | Type 2 diabetes (T2D) is associated with insulin resistance in target tissues including the β-cell, leading to significant β-cell loss and secretory dysfunction. T2D is also associated with aging, and the underlying mechanisms that increase susceptibility of an individual to develop the disease implicate epigenetics: i... | 25,246,382 | [
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Pantothenate and pantetheine antagonize the antitubercular activity of pyrazinamide. | Pyrazinamide (PZA) is a first-line tuberculosis drug that inhibits the growth of Mycobacterium tuberculosis via an as yet undefined mechanism. An M. tuberculosis laboratory strain that was auxotrophic for pantothenate was found to be insensitive to PZA and to the active form, pyrazinoic acid (POA). To determine whether... | 25,246,400 | [
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Metformin and low levels of thyroid-stimulating hormone in patients with type 2 diabetes mellitus. | Small cross-sectional studies have suggested that metformin, a first-line oral hypoglycemic agent, may lower thyroid-stimulating hormone (TSH) levels. Our objective was to determine whether the use of metformin monotherapy, when compared with sulfonylurea monotherapy, is associated with an increased risk of low TSH lev... | 25,246,411 | [
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Comparing histological activity indexes in UC. | Assessment of disease activity in UC is important for designing an optimal therapeutic strategy. No single histology score is considered optimum. The aim of this study was to compare intraobserver reproducibility and the interobserver agreement of available histological UC activity indexes. One hundred and two biopsy s... | 25,246,423 | [
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Wnt pathway in atypical teratoid rhabdoid tumors. | Atypical teratoid rhabdoid tumor (ATRT) is an aggressive pediatric brain tumor with limited therapeutic options. The hypothesis for this study was that the Wnt pathway triggered by the Wnt5B ligand plays an important role in ATRT biology. To address this hypothesis, the role of WNT5B and other Wnt pathway genes was ana... | 25,246,426 | [
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PhaseTank: genome-wide computational identification of phasiRNAs and their regulatory cascades. | Emerging evidence has revealed phased siRNAs (phasiRNAs) as important endogenous regulators in plants. However, the integrated prediction tools for phasiRNAs are still limited. In this article, we introduce a stand-alone package PhaseTank for systematically characterizing phasiRNAs and their regulatory networks. (i) It... | 25,246,430 | [
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Reverse intestinal rotation: a rare case of volvulus around a vitelline duct remnant. | We present a rare case of reverse intestinal rotation with volvulus around a Meckel's diverticulum attached to a vitelline duct remnant. The diagnosis was established by CT. The patient was treated with exploratory laparotomy and small bowel resection. The patient made a full recovery and was discharged home on the sev... | 25,246,458 | [
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Fatal recurrence of fulminant giant cell myocarditis and recovery after initialisation of an alternative immunosuppressive regime. | We report on a challenging case of a 34-year-old male patient with giant cell myocarditis (GCM) and fulminant relapse after discontinuing immunomodulatory therapy 2 years after the initial event. Specific combined immunosuppressive therapy with antithymocyte globulin (ATG), cyclosporine and high-dose glucocorticoids co... | 25,246,472 | [
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Midlife blood pressure change and left ventricular mass and remodelling in older age in the 1946 British Birth Cohort Study. | Antecedent blood pressure (BP) may contribute to cardiovascular disease (CVD) independent of current BP. Blood pressure is associated with left ventricular mass index (LVMI) which independently predicts CVD. We investigated the relationship between midlife BP from age 36 to 64 and LVMI at 60-64 years. A total of 1653 p... | 25,246,483 | [
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The NF-κB regulator Bcl-3 governs dendritic cell antigen presentation functions in adaptive immunity. | Bcl-3 is an atypical member of the IκB family and modulates gene expression via interaction with p50/NF-κB1 or p52/NF-κB2 homodimers. We report in the present study that Bcl-3 is required in dendritic cells (DCs) to assure effective priming of CD4 and CD8 T cells. Lack of Bcl-3 in bone marrow-derived DCs blunted their ... | 25,246,497 | [
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Functional avidity-driven activation-induced cell death shapes CTL immunodominance. | Immunodominance is a complex phenomenon that relies on a mere numerical concept, while being potentially influenced at every step of the immune response. We investigated the mechanisms leading to the establishment of CTL immunodominance in a retroviral model and found that the previously defined subdominant Env-specifi... | 25,246,498 | [
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Brief experimental analysis of reading deficits for children with attention-deficit/hyperactivity disorder. | Reading difficulties are especially high among children with attention-deficit/hyperactivity disorder (ADHD). Although there are a number of empirically supported reading interventions for children with ADHD, there is little data to guide the selection of the most efficacious reading intervention for a specific child. ... | 25,246,507 | [
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Reconstitution of actin-based motility by vasodilator-stimulated phosphoprotein (VASP) depends on the recruitment of F-actin seeds from the solution produced by cofilin. | Vasodilator-stimulated phosphoprotein (VASP) is active in many filopodium-based and cytoskeleton reorganization processes. It is not fully understood how VASP directly functions in actin-based motility and how regulatory proteins affect its function. Here, we combine bead motility assay and single filament experiments.... | 25,246,528 | [
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Antifibrotic therapy in simian immunodeficiency virus infection preserves CD4+ T-cell populations and improves immune reconstitution with antiretroviral therapy. | Even with prolonged antiretroviral therapy (ART), many human immunodeficiency virus-infected individuals have <500 CD4(+) T cells/µL, and CD4(+) T cells in lymphoid tissues remain severely depleted, due in part to fibrosis of the paracortical T-cell zone (TZ) that impairs homeostatic mechanisms required for T-cell s... | 25,246,534 | [
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Dynamical traps lead to the slowing down of intramolecular vibrational energy flow. | The phenomenon of intramolecular vibrational energy redistribution (IVR) is at the heart of chemical reaction dynamics. Statistical rate theories, assuming instantaneous IVR, predict exponential decay of the population with the properties of the transition state essentially determining the mechanism. However, there is ... | 25,246,538 | [
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Complementary symbiont contributions to plant decomposition in a fungus-farming termite. | Termites normally rely on gut symbionts to decompose organic matter but the Macrotermitinae domesticated Termitomyces fungi to produce their own food. This transition was accompanied by a shift in the composition of the gut microbiota, but the complementary roles of these bacteria in the symbiosis have remained enigmat... | 25,246,537 | [
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Emergence of long-range order in sheets of magnetic dimers. | Quantum spins placed on the corners of a square lattice can dimerize and form singlets, which then can be transformed into a magnetic state as the interactions between dimers increase beyond threshold. This is a strictly 2D transition in theory, but real-world materials often need the third dimension to stabilize long-... | 25,246,541 | [
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Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes. | In addition to signaling through the classical tyrosine kinase pathway, recent studies indicate that insulin receptors (IRs) and insulin-like growth factor 1 (IGF1) receptors (IGF1Rs) can emit signals in the unoccupied state through some yet-to-be-defined noncanonical pathways. Here we show that cells lacking both IRs ... | 25,246,545 | [
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Bimodal activation of BubR1 by Bub3 sustains mitotic checkpoint signaling. | The mitotic checkpoint (also known as the spindle assembly checkpoint) prevents premature anaphase onset through generation of an inhibitor of the E3 ubiquitin ligase APC/C, whose ubiquitination of cyclin B and securin targets them for degradation. Combining in vitro reconstitution and cell-based assays, we now identif... | 25,246,557 | [
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Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway. | Imbalances between proinflammatory and proresolving mediators can lead to chronic inflammatory diseases. The balance of arachidonic acid-derived mediators in leukocytes is thought to be achieved through intracellular localization of 5-lipoxygenase (5-LOX): nuclear 5-LOX favors the biosynthesis of proinflammatory leukot... | 25,246,560 | [
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Left-right dissociation of hippocampal memory processes in mice. | Left-right asymmetries have likely evolved to make optimal use of bilaterian nervous systems; however, little is known about the synaptic and circuit mechanisms that support divergence of function between equivalent structures in each hemisphere. Here we examined whether lateralized hippocampal memory processing is pre... | 25,246,561 | [
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The cardiac-specific N-terminal region of troponin I positions the regulatory domain of troponin C. | The cardiac isoform of troponin I (cTnI) has a unique 31-residue N-terminal region that binds cardiac troponin C (cTnC) to increase the calcium sensitivity of the sarcomere. The interaction can be abolished by cTnI phosphorylation at Ser22 and Ser23, an important mechanism for regulating cardiac contractility. cTnC con... | 25,246,568 | [
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α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation. | Physiologically, α-synuclein chaperones soluble NSF attachment protein receptor (SNARE) complex assembly and may also perform other functions; pathologically, in contrast, α-synuclein misfolds into neurotoxic aggregates that mediate neurodegeneration and propagate between neurons. In neurons, α-synuclein exists in an e... | 25,246,573 | [
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Epigenetic dysregulation by nickel through repressive chromatin domain disruption. | Investigations into the genomic landscape of histone modifications in heterochromatic regions have revealed histone H3 lysine 9 dimethylation (H3K9me2) to be important for differentiation and maintaining cell identity. H3K9me2 is associated with gene silencing and is organized into large repressive domains that exist i... | 25,246,589 | [
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Basis for substrate recognition and distinction by matrix metalloproteinases. | Genomic sequencing and structural genomics produced a vast amount of sequence and structural data, creating an opportunity for structure-function analysis in silico [Radivojac P, et al. (2013) Nat Methods 10(3):221-227]. Unfortunately, only a few large experimental datasets exist to serve as benchmarks for function-rel... | 25,246,591 | [
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Extraction of the deciduous canine as an interceptive treatment in children with palatal displaced canines - part I: shall we extract the deciduous canine or not? | To analyse whether extraction of the deciduous canines facilitates eruption of the palatal displaced canines (PDCs), and to analyse root resorption in adjacent teeth caused by the PDCs. Eligibility criteria for participants were as follows: children at age 10-13 years with either maxillary unilateral or bilateral PDC, ... | 25,246,604 | [
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Early neonatal bilirubin, hematocrit, and glucose-6-phosphate dehydrogenase status. | To document the patterns of bilirubin and hematocrit values among glucose-6-phosphate dehydrogenase (G6PD)-deficient and G6PD-normal Nigerian neonates in the first week of life, in the absence of exposure to known icterogenic agents. The G6PD status of consecutive term and near-term neonates was determined, and their b... | 25,246,627 | [
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Binding of WIP to actin is essential for T cell actin cytoskeleton integrity and tissue homing. | The Wiskott-Aldrich syndrome protein (WASp) is important for actin polymerization in T cells and for their migration. WASp-interacting protein (WIP) binds to and stabilizes WASp and also interacts with actin. Cytoskeletal and functional defects are more severe in WIP(-/-) T cells, which lack WASp, than in WASp(-/-) T c... | 25,246,631 | [
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ERBB2 deficiency alters an E2F-1-dependent adaptive stress response and leads to cardiac dysfunction. | The tyrosine kinase receptor ERBB2 is required for normal development of the heart and is a potent oncogene in breast epithelium. Trastuzumab, a monoclonal antibody targeting ERBB2, improves the survival of breast cancer patients, but cardiac dysfunction is a major side effect of the drug. The molecular mechanisms unde... | 25,246,633 | [
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Evidence for distorted mental representation of the hand in osteoarthritis. | Some chronic pain states are associated with a distortion of the perceived size or shape of the painful area, and multisensory illusions that disrupt these dimensions can modulate pain in healthy controls and people with painful disorders. Illusory hand resizing has recently been found to relieve pain in hand OA, raisi... | 25,246,638 | [
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Frequency and time to relapse after discontinuing 6-month therapy with IVIg or pulsed methylprednisolone in CIDP. | We reported that 6-month therapy with intravenous immunoglobulin (IVIg) was more frequently effective or tolerated than intravenous methylprednisolone (IVMP) in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). We now retrospectively compared the proportion of patients who eventually worse... | 25,246,645 | [
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Deletion of L4 domains reveals insights into the importance of ribosomal protein extensions in eukaryotic ribosome assembly. | Numerous ribosomal proteins have a striking bipartite architecture: a globular body positioned on the ribosomal exterior and an internal loop buried deep into the rRNA core. In eukaryotes, a significant number of conserved r-proteins have evolved extra amino- or carboxy-terminal tail sequences, which thread across the ... | 25,246,649 | [
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Metabolic impact of an NADH-producing glucose-6-phosphate dehydrogenase in Escherichia coli. | In Escherichia coli, the oxidative branch of the pentose phosphate pathway (oxPPP) is one of the major sources of NADPH when glucose is the sole carbon nutrient. However, unbalanced NADPH production causes growth impairment as observed in a strain lacking phosphoglucoisomerase (Δpgi). In this work, we studied the metab... | 25,246,670 | [
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Global health research in narrative: a qualitative look at the FICRS-F experience. | For American professional and graduate health sciences trainees, a mentored fellowship in a low- or middle-income country (LMIC) can be a transformative experience of personal growth and scientific discovery. We invited 86 American trainees in the Fogarty International Clinical Research Scholars and Fellows Program and... | 25,246,694 | [
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Neural changes associated with emotion processing in children experiencing peer rejection: a functional MRI study. | This study was performed to investigate differences between children who did and did not experience peer rejection in psychological state through surveys and in emotion processing during an interpersonal stress challenge task to reflect naturalistic interpersonal face-to-face relationships. A total of 20 right-handed c... | 25,246,750 | [
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Extremely elevated international normalized ratio of warfarin in a patient with CYP2C9*1/*3 and thyrotoxicosis. | A 73-yr-old Korean man with permanent atrial fibrillation visited outpatient clinic with severely increased International Normalized Ratio (INR) values after taking a usual starting dosage of warfarin to prevent thromboembolism. We found out later from his blood tests that he had hyperthyroidism at the time of treatmen... | 25,246,753 | [
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Unexpected and permanent central visual loss after removal of intraocular silicone oil. | Here we report a case of unexplained sudden visual loss after removal of silicone oil for rhegmatogenous retinal detachment repair. A patient with visual loss in one eye after removal of silicone oil was investigated with best-corrected Snellen visual acuity assessment, fundus biomicroscopy, optical coherence tomograph... | 25,246,762 | [
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Superior rejection profile during the first 24 months after heart transplantation under tacrolimus as baseline immunosuppressive regimen. | The use of tacrolimus (TAC) in patients after heart transplantation (HTX) has increased over the last few years. In this retrospective study, we evaluated the effects of a TAC (conventional and extended-release TAC)-based immunosuppressive therapy regarding rejection profile in comparison to a cyclosporine A (CSA)-base... | 25,246,772 | [
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Exploring motivations to seek and undergo prosthodontic care: an empirical approach using the Theory of Planned Behavior construct. | Motivations for seeking and undergoing prosthodontic care are poorly understood and are not often explored for clinical purposes when determining treatment need and understanding the factors related to the demand for health care and effective use. This article uses the Theory of Planned Behavior construct to identify f... | 25,246,777 | [
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Carboxyl-modified single-wall carbon nanotubes improve bone tissue formation in vitro and repair in an in vivo rat model. | The clinical management of bone defects caused by trauma or nonunion fractures remains a challenge in orthopedic practice due to the poor integration and biocompatibility properties of the scaffold or implant material. In the current work, the osteogenic properties of carboxyl-modified single-walled carbon nanotubes (C... | 25,246,785 | [
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Nanostructured lipid carrier surface modified with Eudragit RS 100 and its potential ophthalmic functions. | This study was carried out to evaluate the ocular performance of a cationic Eudragit (EDU) RS 100-coated nanostructured lipid carrier (NLC). The genistein encapsulated NLC (GEN-NLC) was produced using the melt-emulsification technique followed by surface absorption of EDU RS 100. The EDU RS 100 increased the surface ze... | 25,246,787 | [
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Biodegradable drug-eluting nanofiber-enveloped implants for sustained release of high bactericidal concentrations of vancomycin and ceftazidime: in vitro and in vivo studies. | We developed biodegradable drug-eluting nanofiber-enveloped implants that provided sustained release of vancomycin and ceftazidime. To prepare the biodegradable nanofibrous membranes, poly(D,L)-lactide-co-glycolide and the antibiotics were first dissolved in 1,1,1,3,3,3-hexafluoro-2-propanol. They were electrospun into... | 25,246,790 | [
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Association between smoking and cognitive impairment in multiple sclerosis. | Although smoking is known to cause various symptoms in multiple sclerosis (MS) patients, there have been no reports regarding the relationship between smoking and cognitive impairment in MS. Studying the effects of cigarette smoking in MS patients is imperative as there is a high prevalence of cognitive impairment in M... | 25,246,792 | [
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Cognitive assessments for the early diagnosis of dementia after stroke. | The early detection of poststroke dementia (PSD) is important for medical practitioners to customize patient treatment programs based on cognitive consequences and disease severity progression. The aim is to diagnose and detect brain degenerative disorders as early as possible to help stroke survivors obtain early trea... | 25,246,795 | [
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Effect of delayed intrathecal administration of capsaicin on neuropathic pain induced by chronic constriction injury of the sciatic nerve in rats. | The current study was designed to examine the antinociceptive effect of intrathecally administered capsaicin, a transient receptor potential vanilloid 1 receptor agonist, in a rat model of neuropathic pain induced by unilateral sciatic nerve chronic constriction injury. Male adult Sprague Dawley rats were randomly assi... | 25,246,806 | [
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Cowden syndrome presenting as breast cancer: imaging and clinical features. | Cowden syndrome is an uncommon, autosomal dominant disease which is characterized by multiple hamartomas of the skin, mucous membrane, brain, breast, thyroid, and gastrointestinal tract. The diagnosis of Cowden syndrome implicates an increased risk of developing breast cancer. We report a case of a 22-year-old woman wi... | 25,246,819 | [
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Internal iliac artery embolization during an endovascular aneurysm repair with detachable interlock microcoils. | The purpose of this study was to evaluate the effectiveness of detachable interlock microcoils for an embolization of the internal iliac artery during an endovascular aneurysm repair (EVAR). A retrospective review was conducted on 40 patients with aortic aneurysms, who had undergone an EVAR between January 2010 and Mar... | 25,246,822 | [
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Breaking into the International Arena: Malaysian Journal of Medical Sciences publishing Report 2013. | The most recent Malaysian Journal of Medical Sciences (MJMS)-MyCite report has shown that it has achieved a level becoming of a leading national medical science journal. This editorial reports on submission and acceptance rates of MJMS throughout the year 2013 and their geographical contributors. Our rejection rate of ... | 25,246,830 | [
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Mycobacterium szulgai pulmonary infection: case report of an uncommon pathogen in Korea. | Mycobacterium szulgai (M. szulgai) is an unusual pathogen in a human non-tuberculous mycobacterial infection. Pulmonary infection due to M. szulgai may be clinically and radiologically confused with active pulmonary tuberculosis. In contrast to other non-tuberculous mycobacteria, M. szulgai infection is well controlled... | 25,246,828 | [
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Histopathological Study of the Lungs of Mice Receiving Human Secretory IgA and Challenged with Mycobacterium tuberculosis. | Humoral and cellular immune responses are associated with protection against extracellular and intracellular pathogens, respectively. In the present study, we evaluated the effect of receiving human secretory immunoglobulin A (hsIgA) on the histopathology of the lungs of mice challenged with virulent Mycobacterium tube... | 25,246,833 | [
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Analysis of mechanical strength to fixing the femoral neck fracture in synthetic bone type Asnis. | To analyze the results of biomechanical assays of fixation of Pauwels type III femoral neck fracture in synthetic bone, using 7.5mm cannulated screws in inverted triangle formation, in relation to the control group. TEN SYNTHETIC BONES WERE USED, FROM A DOMESTIC BRAND, DIVIDED INTO TWO GROUPS: test and control. In the ... | 25,246,851 | [
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0.1201962,
0.149896,
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Clinical and demographic study on open fractures caused by motorcycle traffic accidents. | To assess socio-demographic characteristics of individuals that suffered open fractures caused by motorcycle traffic accident and evaluate infection rate in search of associated risk factors. A retrospective study comprising 81 patients with open fractures caused by motorcycle accidents was carried out. Clinic and soci... | 25,246,853 | [
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Simultaneous Computation of Dynamical and Equilibrium Information Using a Weighted Ensemble of Trajectories. | Equilibrium formally can be represented as an ensemble of uncoupled systems undergoing unbiased dynamics in which detailed balance is maintained. Many nonequilibrium processes can be described by suitable subsets of the equilibrium ensemble. Here, we employ the "weighted ensemble" (WE) simulation protocol [Huber and Ki... | 25,246,856 | [
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Effects of starting powder and thermal treatment on the aerosol deposited BaTiO3 thin films toward less leakage currents. | To prepare high-density integrated capacitors with low leakage currents, 0.2-μm-thick BaTiO3 thin films were successfully deposited on integrated semiconductor substrates at room temperature by the aerosol deposition (AD) method. In this study, the effects of starting powder size were considered in an effort to remove ... | 25,246,860 | [
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Sex hormone levels and sexual dysfunction in men after coronary artery bypass graft. | Sexual dysfunction is one of the most common problems in men after coronary artery bypass graft (CABG). Etiology of sexual dysfunction in these patients may be psychological or organic due to hormonal changes. The purpose was to evaluate the incidence and type of sexual dysfunction and changes in serum concentration of... | 25,246,907 | [
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Effect of combined density gradient centrifugation on X- and Y- sperm separation and chromatin integrity. | It has been claimed that by using different washing methods, the sperms can be separated according to size, motility, density, chromosomal content and surface markings and charge. These methods also reduce sperm chromatin deficiencies and screen the sperms before applying in assisted reproduction techniques. This study... | 25,246,909 | [
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Recommended foods for male infertility in Iranian traditional medicine. | Male infertility accounts for 30-50% of all infertilities among couples. Iranian traditional medicine (ITM) stressed the importance of nutrition in the prevention and treatment of male infertility. Many Iranian traditional physicians have described the traits of specific foods for prevention and treatment of male infer... | 25,246,919 | [
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Evaluation of two DNA extraction methods from maternal plasma for using in non-invasive bovine fetus gender determination. | Fetal DNA in maternal plasma and serum has been shown to be a useful material for prenatal fetal sex determination during early gestational ages. Non-invasive prenatal diagnosis is now possible at 8(th) week of pregnancy, by maternal blood sample testing. The purpose of this study was to evaluate two DNA extraction met... | 25,246,921 | [
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Investigation of the prevalence of female genital tract tuberculosis and its relation to female infertility:An observational analytical study. | Genital tuberculosis is a common entity in gynecological practice particularly among infertile patients. It is rare in developed countries but is an important cause of infertility in developing countries. The present study has investigated the prevalence of female genital tract tuberculosis (FGT) among infertile patien... | 25,246,930 | [
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Role of PPAR γ in the Differentiation and Function of Neurons. | Neuronal processes (neurites and axons) have an important role in brain cells communication and, generally, they are damaged in neurodegenerative diseases. Recent evidence has showed that the activation of PPARγ pathway promoted neuronal differentiation and axon polarity. In addition, activation of PPARγ using thiazoli... | 25,246,934 | [
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Supercritical carbon dioxide: a solvent like no other. | Supercritical carbon dioxide (scCO2) could be one aspect of a significant and necessary movement towards green chemistry, being a potential replacement for volatile organic compounds (VOCs). Unfortunately, carbon dioxide has a notoriously poor solubilising power and is famously difficult to handle. This review examines... | 25,246,947 | [
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Relay cross metathesis reactions of vinylphosphonates. | Dimethyl (β-substituted) vinylphosphonates do not readily undergo cross metathesis reactions with Grubbs catalyst and terminal alkenes. However, the corresponding mono- or diallyl vinylphosphonate esters undergo facile cross metathesis reactions. The improved reactivity is attributed to a relay step in the cross metath... | 25,246,952 | [
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Lateral ordering of PTCDA on the clean and the oxygen pre-covered Cu(100) surface investigated by scanning tunneling microscopy and low energy electron diffraction. | We have investigated the adsorption of perylene-3,4,9,10-tetracarboxylic acid dianhydride (PTCDA) on the clean and on the oxygen pre-covered Cu(100) surface [referred to as (√2 × 2√2)R45° - 2O/Cu(100)] by scanning tunneling microscopy (STM) and low energy electron diffraction (LEED). Our results confirm the (4√2 × 5√2)... | 25,246,964 | [
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... |
Second generation silver(I)-mediated imidazole base pairs. | The imidazole-Ag(I)-imidazole base pair is one of the best-investigated artificial metal-mediated base pairs. We show here that its stability can be further improved by formally replacing the imidazole moiety by a 2-methylimidazole or 4-methylimidazole moiety. A comparison of the thermal stability of several double hel... | 25,246,972 | [
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Visible light photoredox-catalyzed deoxygenation of alcohols. | Carbon-oxygen single bonds are ubiquitous in natural products whereas efficient methods for their reductive defunctionalization are rare. In this work an environmentally benign protocol for the activation of carbon-oxygen single bonds of alcohols towards a reductive bond cleavage under visible light photocatalysis was ... | 25,246,974 | [
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Synthesis and optical properties of pyrrolidinyl peptide nucleic acid carrying a clicked Nile red label. | DNA or its analogues with an environment-sensitive fluorescent label are potentially useful as a probe for studying the structure and dynamics of nucleic acids. In this work, pyrrolidinyl peptide nucleic acid (acpcPNA) was labeled at its backbone with Nile red, a solvatochromic benzophenoxazine dye, by means of click c... | 25,246,975 | [
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Molecular recognition of AT-DNA sequences by the induced CD pattern of dibenzotetraaza[14]annulene (DBTAA)-adenine derivatives. | An investigation of the interactions of two novel and several known DBTAA-adenine conjugates with double-stranded DNA and RNA has revealed the DNA/RNA groove as the dominant binding site, which is in contrast to the majority of previously studied DBTAA analogues (DNA/RNA intercalators). Only DBTAA-propyladenine conjuga... | 25,246,976 | [
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A case of vasculitis, retinitis and macular neurosensory detachment presenting post typhoid fever. | Ocular and extraocular immune-mediated phenomena are known to occur following febrile illness. Vasculitis, retinitis and neurosensory detachment are not well-recognized sequelae of typhoid fever. We report a case of vasculitis, retinitis and macular neurosensory detachment presenting post typhoid fever. A 27-year-old f... | 25,246,983 | [
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Reducing the use of benzodiazepines and cyclopyrrolones in clinical practice. | Recently, the use of benzodiazepines (BZD) and cyclopyrrolones (CP) has drawn a great deal of attention. About 100,000 patients - approximately 2% of the Danish population - are believed to be addicted to BZD. This article describes a simple and effective method of reducing the use of dependency-producing drugs in clin... | 25,247,003 | [
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Skeletal malocclusion: a developmental disorder with a life-long morbidity. | The likelihood of birth defects in orofacial tissues is high due to the structural and developmental complexity of the face and the susceptibility to intrinsic and extrinsic perturbations. Skeletal malocclusion is caused by the distortion of the proper mandibular and/or maxillary growth during fetal development. Patien... | 25,247,012 | [
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BE-SAFE: Bedside sonography for assessment of the fetus in emergencies: educational intervention for late-pregnancy obstetric ultrasound. | Late obstetric emergencies are time critical presentations in the emergency department. Evaluation to ensure the safety of mother and child includes rapid assessment of fetal viability, fetal heart rate (FHR), fetal lie, and estimated gestational age (EGA). Point-of-care (POC) obstetric ultrasound (OBUS) offers the adv... | 25,247,032 | [
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Impact of post-intubation interventions on mortality in patients boarding in the emergency department. | Emergency physicians frequently perform endotracheal intubation and mechanical ventilation. The impact of instituting early post-intubation interventions on patients boarding in the emergency department (ED) is not well studied. We sought to determine the impact of post-intubation interventions (arterial blood gas samp... | 25,247,049 | [
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Ultrasound detection of superior vena cava thrombus. | Superior vena cava (SVC) syndrome is most commonly the insidious result of decreased vascular flow through the SVC due to malignancy, spontaneous thrombus, infections, and iatrogenic etiologies. Clinical suspicion usually leads to computed tomography to confirm the diagnosis. However, when a patient in respiratory dist... | 25,247,051 | [
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Mitochondria-targeted antioxidant prevents cardiac dysfunction induced by tafazzin gene knockdown in cardiac myocytes. | Tafazzin, a mitochondrial acyltransferase, plays an important role in cardiolipin side chain remodeling. Previous studies have shown that dysfunction of tafazzin reduces cardiolipin content, impairs mitochondrial function, and causes dilated cardiomyopathy in Barth syndrome. Reactive oxygen species (ROS) have been impl... | 25,247,053 | [
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Socioeconomic status does not predict cocaine use among ischemic stroke patients: A nested case-control study. | Previous studies of cocaine use and stroke have focused on acute effects of cocaine in perceived high-risk populations. We characterized mechanisms and risk factors for cocaine use among ischemic stroke patients from a broad range of socioeconomic backgrounds to inform medical management decisions and prevention effort... | 25,247,073 | [
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Gasless minimum incision access used for extracorporeal orthotopic bladder substitution after laparoscopic radical cystectomy. | Radical cystectomy is the gold standard for treating invasive bladder cancer. We report our outcomes of gasless minimum incision access (GMIA) for extracorporeal orthotopic bladder substitution (ECOBS) after laparoscopic radical cystectomy. Radical surgery was performed in patients in the same hospital suffering from b... | 25,247,092 | [
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Nano-rings with a handle - Synthesis of substituted cycloparaphenylenes. | The research of cycloparaphenylenes (CPPs), the smallest armchair carbon nanotube, has been a quest for the past decades which experienced a revival in 2008 when the first synthesis was achieved. Since then CPPs with various ring sizes have been realized. The incorporation of substituents and the synthesis of CPPs with... | 25,247,115 | [
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Liquid fuel cells. | The advantages of liquid fuel cells (LFCs) over conventional hydrogen-oxygen fuel cells include a higher theoretical energy density and efficiency, a more convenient handling of the streams, and enhanced safety. This review focuses on the use of different types of organic fuels as an anode material for LFCs. An overvie... | 25,247,123 | [
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The cell-type specific uptake of polymer-coated or micelle-embedded QDs and SPIOs does not provoke an acute pro-inflammatory response in the liver. | Semiconductor quantum dots (QD) and superparamagnetic iron oxide nanocrystals (SPIO) have exceptional physical properties that are well suited for biomedical applications in vitro and in vivo. For future applications, the direct injection of nanocrystals for imaging and therapy represents an important entry route into ... | 25,247,125 | [
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0.04679246,
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Near-field photochemical and radiation-induced chemical fabrication of nanopatterns of a self-assembled silane monolayer. | A general concept for parallel near-field photochemical and radiation-induced chemical processes for the fabrication of nanopatterns of a self-assembled monolayer (SAM) of (3-aminopropyl)triethoxysilane (APTES) is explored with three different processes: 1) a near-field photochemical process by photochemical bleaching ... | 25,247,126 | [
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Microarray Analysis of Gene Expression Reveals that Cyclo-oxygenase-2 Gene Therapy Up-regulates Hematopoiesis and Down-regulates Inflammation During Endochondral Bone Fracture Healing. | Cyclo-oxygenase-2 (Cox-2) is an inflammatory mediator that is necessary for the tissue repair, including bone fracture healing. Although the application of Cox-2 gene therapy to a murine closed femoral fracture has accelerated bony union, but the beneficial effect was not observed until the endochondral stage of bone r... | 25,247,155 | [
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Efficacy of Dual Energy X-ray Absorptiometry for Evaluation of Biomechanical Properties: Bone Mineral Density and Actual Bone Strength. | Bone mineral density (BMD) is an important index in diagnosis of osteoporosis and other metabolic bone diseases, prediction of fractures, and monitoring treatment. This study was to find a more feasible technique for prediction of osteoporotic fracture between dual energy X-ray absorptiometry (DXA) and quantitative com... | 25,247,158 | [
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Study of the polycarbonate-urethane/metal contact in different positions during gait cycle. | Nowadays, a growing number of young and more active patients receive hip replacement. More strenuous activities in such patients involve higher friction and wear rates, with friction on the bearing surface being crucial to ensure arthroplasty survival in the long term. Over the last years, the polycarbonate-urethane ha... | 25,247,180 | [
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Clinical correlates of Hachinski ischemic score and vascular factors in cognitive function of elderly. | The aim of this study is to investigate the relationship between Hachinski ischemic score (HIS) and vascular factors as well as between HIS and the cognitive function in elderly community. Demographic characteristics, such as sex, age, education, history of drinking and smoking, family history of dementia and stroke, d... | 25,247,189 | [
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One adaptive synchronization approach for fractional-order chaotic system with fractional-order 1 < q < 2. | Based on a new stability result of equilibrium point in nonlinear fractional-order systems for fractional-order lying in 1 < q < 2, one adaptive synchronization approach is established. The adaptive synchronization for the fractional-order Lorenz chaotic system with fractional-order 1 < q < 2 is considered.... | 25,247,207 | [
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Anticipatory looks reveal expectations about discourse relations. | Previous research provides evidence for expectation-driven processing within sentences at phonological, lexical, and syntactic levels of linguistic structure. Less well-established is whether comprehenders also anticipate pragmatic relationships between sentences. To address this, we evaluate a unit of discourse struct... | 25,247,235 | [
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Zinc-specific intramolecular excimer formation in TQEN derivatives: fluorescence and zinc binding properties of TPEN-based hexadentate ligands. | Zn(2+)-induced fluorescence enhancement of the TPEN (N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine)-based ligand, N,N-bis(1-isoquinolylmethyl)-N',N'-bis(pyridylmethyl)ethylenediamine (N,N-1-isoBQBPEN, 1b), has been investigated. Upon Zn(2+) binding, 1b shows a fluorescence increase (ϕZn = 0.028) at 353 and 475 nm.... | 25,247,241 | [
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Long-term outcomes after revision neural decompression and fusion for same-level recurrent lumbar stenosis: defining the effectiveness of surgery. | Single-cohort study of patients undergoing revision neural decompression and fusion for same-level recurrent lumbar stenosis. To assess the long-term outcomes of revision surgery using validated patient-reported outcomes measures. Recurrent lumbar stenosis may occur after lumbar spine surgery, leading to significant di... | 25,247,253 | [
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The adsorption of ochratoxin a by lactobacillus species. | The objective of this study was to examine ochratoxin A (OTA) binding by three lactic acid bacteria (LAB) species: Lactobacillus plantarum, L. brevis, and L. sanfranciscensis. Experiments were conducted using MRS medium and PBS buffer contaminated with 1000 ng/mL OTA and inoculated with live or thermally inactivated ba... | 25,247,265 | [
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FDG PET/CT images demonstrating epididymo-orchitis in a patient with HIV, acute kidney injury and known epididymo-orchitis on scrotal ultrasound. | A 52-year-old man with HIV was referred for an F-FDG PET/CT scan for the cause of kidney injury. FDG PET/CT scan revealed increased renal cortical FDG activity, which can be seen in HIV nephropathy or acute interstitial nephritis. Diffuse increased FDG uptake was demonstrated within the right testicle and epididymis, c... | 25,247,269 | [
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High systemic levels of the cytokine-inducing HMGB1 isoform secreted in severe macrophage activation syndrome. | Macrophage activation syndrome (MAS) is a potentially fatal complication of systemic inflammation. High mobility group box 1 (HMGB1) is a nuclear protein extensively leaked extracellularly during necrotic cell death or actively secreted by natural killer (NK) cells, macrophages and additional cells during infection or ... | 25,247,290 | [
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Benchmarking undedicated cloud computing providers for analysis of genomic datasets. | A major bottleneck in biological discovery is now emerging at the computational level. Cloud computing offers a dynamic means whereby small and medium-sized laboratories can rapidly adjust their computational capacity. We benchmarked two established cloud computing services, Amazon Web Services Elastic MapReduce (EMR) ... | 25,247,298 | [
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Genetic diversity and levels of expression of factor H binding protein among carriage isolates of Neisseria meningitidis. | The prevention of meningococcal disease may be improved by recombinant vaccines such as 4CMenB and rLP2086 that target the factor H binding protein (fHbp), an immunogenic surface component of Neisseria meningitidis present as one of three variants. Whether such vaccines decrease carriage of invasive isolates and thus i... | 25,247,300 | [
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Fluorescent bilayer nanocoils assembled from an asymmetric perylene diimide molecule with ultrasensitivity for amine vapors. | Highly fluorescent bilayer nanocoils assembled from an asymmetric perylene diimide molecule exhibit unprecedented sensitivity to trace amines, that is, three orders of magnitude greater than our previously reported solid nanofibers. The coiled nanostructure design for new sensing materials offers a novel option for opt... | 25,247,350 | [
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Human evolution: genomic gifts from archaic hominins. | The dispersal of humans throughout the world was accompanied by adaptations to local environments. New research shows that a previously identified haplotype of the EPAS1 gene, which allows Tibetans to live at high altitude, was inherited from archaic hominin ancestors. | 25,247,359 | [
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It's all about the constraints. | Our ever-growing knowledge about the human brain and human behavior is opening doors to increasingly impressive technological achievements. This neurobiological inspiration has a significant history and involves almost equal parts neuroscience, computation and art. With a focus on the sense of vision, this essay presen... | 25,247,361 | [
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... |
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