title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Immunologic aspects of 1, 2-dimethylhydrazine-induced colon tumors in rats. | Investigation of immunologic aspects of colon tumors induced in rats by 1,2-dimethylhydrazine demonstrated that: 1) An antigen in an extract of colon tumors was not detected in the normal colon. It was related to antigens in rat fetuses and did not cross-react immunologically with carcinoembryonic antigen. 2) Mucinous ... | 165,314 | [
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Oncogenic transformation of murine lymphoid cells by in vitro infection with Abelson leukemia virus. | Spleen cell cultures stimulated to DNA synthesis by antigen or mitogen were infected with Abelson virus, a C-type RNA virus inducing nonthymic lymphomas in mice. After 3 days the cells were transferred to mice and caused 100 percent incidence of lymphomas in as few as 29 days. That a number of the tumors were of donor ... | 165,315 | [
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Human plasma triglyceride labeling after high sucrose feeding. II. Study on triglyceride kinetics and postheparin lipolytic activity. | Kinetic studies of the very-low-density lipoprotein triglycerides (VLDL-TG) turnover by endogenous labeling with glycerol-2-3-H were performed in 13 patients in the postabsorptive state, first after 10-14 days on a low-sucrose high-starch diet, then again after 10-14 days of isocaloric high-sucrose low-starch diet (HSD... | 165,366 | [
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In vitro cultivation of cells from the chorioallantoic membrane of chick embryos. | By treatment of chorioallantoic membranes from embryonated eggs with collagenase and hyaluronidase before the conventional application of trypsin cells could be grown in culture which supported growth of a large variety of myxoviruses, herpesviruses, avian reoviruses and the infectious bronchitis virus of chickens. The... | 165,393 | [
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Mononeuropathy multiplex as a complication of amphetamine angiitis. | A patient who abused multiple drugs developed a rapidly progressive mononeuropathy multiplex, which appeared to respond to corticosteroid therapy with partial resolution. Intravenous methamphetamine had been used almost exclusively from the fourth month prior to the onset of symptoms. Biopsy material revealed a necroti... | 165,440 | [
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Determination of the 3' terminal nucleotide of DNA fragments. | A new method for determining the 3'-terminal nucleotide of a DNA strand is presented. Use is made of the fact that one (and only one) 2',3'-dideoxyribonucleotide can be added to the 3'-end of a DNA fragment with calf thymus terminal transferase. Addition of more than one nucleotide analog per strand is impossible due t... | 165,468 | [
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Antiviral activity of polynucleotides: copolymers of inosinic acid and N2-dimethylguanylic of 2-methylthioinosinic acid. | Complexes of poly(C) with copolymers of inosinic acid containing various amounts of mismatched bases (see journal for formula) have been examined for direct resistance to virus infection, interferon induction and toxicity in two different cell cultures (primary rabbit kidney cells and mouse L-929 cells). Complexes in w... | 165,469 | [
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Induction of erythroid differentiation in murine virus infected eythroleukemia cells by highly polar compounds. | Murine-virus-infected erythroleukemia cells cultured in a medium with dimethylsulfoxide or N,N-dimethylformamide are induced to differentiate to erythroid cells. A number of highly polar compounds have a similar effect in inducing erythroid differentiation of the virus-infected cells, as assayed by the appearance of he... | 165,480 | [
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[Stimulation of the protein synthesizing capacity of thyroid gland polyribosomes in vitro under the influence of cyclic adenosine-3', 5'-monophosphate]. | It was shown that cAMP increased the capacity of polyribosomes of the thyroid glands to the labeled phenylalanine incorporation into the protein by 51 per cent. Preincubation of microsomes or ribosomes with cAMP in the cell-free protein-synthesizing system also increased the incorporation of the labeled amino acids in... | 165,479 | [
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Regulation of herpesvirus macromolecular synthesis: sequential transition of polypeptide synthesis requires functional viral polypeptides. | It was previously shown that virus-specific polypeptides made in HEp-2 cells infected with herpes simplex 1 form three groups designated alpha, beta, and gamma whose synthesis is coordinately regulated and sequentially ordered. This report shows that one or more functional alpha polypeptides are necessary to turn on th... | 165,503 | [
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Cytotoxic effector cells specific for B Cell lines transformed by Epstein-Barr virus are present in patients with infectious mononucleosis. | Peripheral lymphoid cells, from 12 cases of acute infectious mononucleosis (IM), were tested in a micro chromium-51 release assay for cytotoxic activity against a variety of cell lines that did or did not carry the Epstein-Barr virus (EBV) genome. Unfractionated lymphocytes from these patients were cytotoxic to both ty... | 165,518 | [
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Functional intermediates in reaction of cytochrome oxidase with oxygen. | The development of a low temperature kinetic method for the flash photolysis of the compounds of membrane-bound cytochrome a3 with carbon monoxide in the presence of oxygen affords evidence for three categories of functional intermediate compounds of cytochrome a3 and oxygen. The three classes are identified as follows... | 165,519 | [
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An improved method of fixation for immunofluorescent detection of SV40 T-antigen in infected human fibroblasts. | Improved fixation for immunofluorescence staining in the SV40 T-antigen test has been developed utilizing ethanol in place of acetone. The modified method improves resolution, results in smaller variability of cell numbers, and reduces the time of assay, while maintaining its sensitivity in discriminating between norm... | 165,531 | [
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Effects of endurance exercise on serum enzyme activities in the dog, pig and man. | Daily levels of GOT, GPT, AK and LDH did not change consistently with exercise in any species. The level of CPK each day before exercise presented a consistent rise during the week of exercise in the dog and man but not in the pig. By the third day of resting, all enzyme activities were at control levels. The probable ... | 165,535 | [
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Stress polycythemia--a pathophysiologic study. | Two patients with "Gaisböck syndrome" (stress polycythemia) were found to have been under chronic "stress" with REM sleep decrease, decreased nocturnal ADH-like activity and consequent nocturnal water loss. The role of REM decrease with chronic "stress" in causing secondary decrease in nocturnal ADH-like activity was e... | 165,576 | [
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The in vivo uptake of tritiated estradiol in carcinoma of the breast. | In human beings, the uptake of radiolabeled estradiol suppressed by carcinomatous breast tissue in vivo in relation to adipose breast tissue has been studied in 20 patients. The ratio of tumor uptake to fat tissue uptake was correlated with the age of the patient, menopausal status, presence of axillary metastases at t... | 165,580 | [
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Glandular tumors of the palate. | Salivary gland tumors of the palate originate in the minor salivary glands located in the glandular zone of the palate. Approximately 7 per cent of all tumors of the salivary gland occur in the palate, and approximately one-half of such tumors are cancers. The salivary gland tumor is more often found in the hard palate... | 165,581 | [
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The sarcoma arising in giloblastoma: clinico-pathological report of two cases. | Two cases of primary brain tumor composed of an admixture of sarcomatous and gliomatous tissues are reported together with their clinical courses and neurosurgical examination. There is no difference in clinical course nor in the result of examination between the usual glioblastoma multiforme and these admixture tumor.... | 165,588 | [
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Alterations in cyclic necleotides in dogs after triiodothyronine. | The effects of triiodothyronine (T3) on plasma and tissue levels (liver, adipose tissue, muscle) of adenosine 3',5'-monophosphate (cyclic GMP) were determined in Mongrel dogs. Plasma cyclic AMP increased to a mean plateau value 165% greater than control values in response to a single intravenous injection of T3 (100-20... | 165,647 | [
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Age dependence of plasma oestrogen response to HCG and ACTH in men. | Twelve men, 19-40 years old, and 12 men, 60-86 years old, were given ACTH and in a second test series, HCG. Oestrone, oestradiol-17beta and cortisol were measured in the plasma before and after stimulation. Under basal conditions oestrone and oestradiol as well as the percentage binding of testosterone increased signif... | 165,649 | [
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Virus antibody levels in the cerebrospinal fluid from patients with optic neuritis. | Virus antibody levels were studied in the cerebrospinal fluid (CSF) of 58 patients with optic neuritis and 58 control patients with no indication of multiple sclerosis (MS) or infectious disorders of the central nervous system (CNS). The specimens were tested against three different structural components of measles vir... | 165,653 | [
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Relationship between cyclic AMP metabolism and inotropic response of perfused rat hearts to phenylephrine and other adrenergic amines. | A positive correlation between inotropic response and increment of cyclic AMP levels and labeling (from 14-C-adenine in the perfusate) was found after isoprenaline, dopamine, and phenylephrine alone, and after isoprenaline in the presence of chlorpromazine. 2. a lack of correlation between contractile activity and cycl... | 165,678 | [
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Regulation of cyclic AMP content in normal and malignant brain cells. | Pharmacologic characterization of the neurotransmitter-sensitive cyclic AMP-second messenger systems of brain has proven to be a complex and difficult endeavor. At least two types of receptor appear to be involved in the mediation of the effects of NE on cyclic AMP content. One of these receptor systems appears to medi... | 165,690 | [
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Comparisons of major cell-surface proteins of normal and transformed cells. | Transformation of the chick fibroblast surface has been studied in cells infected with Schmidt-Ruppin Rous sarcoma virus and the temperature-sensitive mutant of this virus, TS-68. Major findings following transformation induced by a shift from nonpermissive (41 C.) to permissive (36 C.) temperature in TS-68 infected ce... | 165,707 | [
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Composition of membranes of cells transformed by tumorigenic DNA and RNA viruses. | Continuous cell lines obtained from mouse and hamster embryonic tissue and human lung contain a homologous series of acidic glycolipids known as gangliosides. These complex lipids are highly concentrated in plasma cell membranes. The ganglioside pattern becomes greatly simplified when cells are transformed by tumorigen... | 165,709 | [
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Cholagiocarcinoma in a patient previously given thorotrast. | The long-term effects of thorotrast administration include local granulomas, blood cell abnormalities, and cancer. To date, more than 100 cases of liver cancer have been reported in patients previously given this radioactive contrast material, with a latency period of approximately 22 years. We report such a case; the ... | 165,715 | [
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Crohn's disease of the colon. III. Toxic dilatation of the colon in Crohn's colitis. | In a group of 160 patients with Crohn's disease involving the colon, there were seven patients with toxic dilatation, four with granulomatous colitis and three with ileocolitis, all successfully treated without mortality. This complications is more common than previously recognized in Crohn's colitis. In Crohn's diseas... | 165,716 | [
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Afferent aortic nerve fibers with their pathways in cardiac sympathetic nerves. | The effect of mechanical and chemical stimulation on activity of afferent aortic nerve fibers with pathways in the cardiac sympathetic nerves has been examined. Action potentials were derived from the second or third thoracic communicating ramus of the left side of anesthetized dogs. Thirty myelinated and 19 unmyelinat... | 165,728 | [
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0.07057343,
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-0.347337,
-0.2228755,
0.2391481,
0.2545399,
0.273485... |
Actions of a new muscle relaxant (AH8165) on neuromuscular transmission. | The effects of a new muscle relaxant, AH8165, on miniature endplate potential (MEPP) amplitude and frequency, endplate sensitivity to acetylcholine, and muscle twitch tension were studied in vitro in the frog sartorius muscle. Nerve terminal effects were studied in vivo in the cat soleus muscle and its ventral root fib... | 165,756 | [
0.1222108,
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0.2667054,
0.1839613,... |
Thymosin-induced differentiation of murine thymocytes in allogeneic mixed lymphocyte cultures. | Calf thymosin is shown to enhance the one-way MLR of CBA thymocytes cultured with allogeneic mitomycin-C- treated C57BL/J6 spleen cells. Thymosin does not enhance the one-way MLR of CBA thymocytes cultured with syngeneic mitomucin-C-treated spleen cells. Based on this finding we present a relatively simple, rapid and q... | 165,764 | [
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0.04351493,
0.4117931,
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0.118638... |
Value of special auditory tests in the latero-medial inferior pontine syndrome. | Results from a special battery of auditory tests are used to document, for the first time, recovery from a total unilateral hearing loss occurring as part of a latero-medial inferior pontine syndrome. Although sensitivity for pure tones and speech was regained within two months of onset, definite retrocochlear signs pe... | 165,772 | [
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0.01623229,
0.1236233,
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0.002774246,
0.04730215,
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0.379675... |
Sexual precocity associated with a hypothalamic tumour. Effects of sex hormone therapy. | A case of sexual precocity of unusually early onset and associated with a hypothalamic tumour is described. The effects of ethinyl oestradiol and medroxyprogesterone acetate treatment have been monitored by plasma testosterone, FSH, and LH estimations. The results suggested a partial suppression of the tumour's influen... | 165,785 | [
-0.09804191,
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0.09770189,
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Bone changes in congenital cytomegalic inclusion disease. | We report the case of a female infant born with cytomegalic inclusion disease, in whom bone changes were present in x-rays of the tibiae and femora. She was the mother's first child and was born 8 days postmature after a normal delivery; birthweight 2.52 kg. Many infarcts were seen in the placenta. The mother had a fev... | 165,786 | [
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0.13486,
0.1649373,
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-0... |
Collagen metabolism in rat lungs during chronic intermittent exposure to oxygen. | Collagen metabolism was studied in rat lungs during prolonged intermittent exposure to oxygen. After an initial of 2-d exposure to oxygen, the rats alternately breathed air and oxygen in 24-h periods up to 30 d. Lung histology showed perivascular edema as an early sign of oxygen toxicity. Increased capillary permeabili... | 165,807 | [
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0.3935915,
0.1950987,
0.4874211,
0.09655505,
... |
An examination of octanol and octanal metabolism to octanoic acid by horse liver alcohol dehydrogenase. | The kinetics of the horse liver alcohol dehydrogenase (alcohol: NAD+ oxidoreductase EC 1.1.1.1) catalyzed metabolism of octanol and octanal to octanoic acid have been examined. On incubation of octanol with horse liver alcohol dehydrogenase in the presence of NAD+, NADH as well as octanal and octanoic acid were seen as... | 165,828 | [
-0.2357674,
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0.141521,
0.3487381,
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0.18075... |
Role of cyclic adenosine 3',5'-monophosphate in the isoprenaline-induced relaxation of the oestrogen dominated rabbit uterus. | 1. The role of cyclic adenosine 3',5'-monophosphate (cyclic AMP) in the relaxation produced by isoprenaline in muscle strips from the oestrogen dominated rabbit uterus has been investigated. 2. Isoprenaline 2 times 10- minus 8 M produced an inhibition of the mechanical activity but no increase in cyclic AMP. Isoprenali... | 165,846 | [
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0.1876638,
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0.4469466,
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-0.2012878... |
Peripheral neuropathy and indomethacin. | A patient with seronegative inflammatory polyarthritis developed a predominantly motorperipheral neuropathy associated with the use of indomethacin. Three other cases of peripheral neuropathy associated with indomethacin treatment have been reported to the Committee on Safety of Medicines. In all cases the neuropathy r... | 165,855 | [
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0.03759911,
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0.2019045... |
Enzymes of fructose metabolism in human kidney. | Activities of enzymes involved in fructose metabolism were measured in samples of human kidney cortex and medulla. The enzymes are ketohexokinase, aldolase, NAD- and NADP-dependent alcohol dehydrogenase, aldehyde dehydrogenase, triokinase and glycerate kinase; hexose biphosphatase and sorbitol dehydrogenase were also i... | 165,931 | [
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0.2310855,
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0.... |
Gastric acid secretion and sleep stages during natural night sleep. | Gastric acid secretion during natural sleep was studied in 4 healthy female volunteers for 11 nights. Acid output was measured by means of intragastric titration and a telemetering capsule, and sleep was monitored continuously by recording EEG and eye movements. Compared to the waking state, sleep was found to be assoc... | 166,004 | [
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0.2375146,
0.01179853,
0.2994284,
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-0.03872221... |
Interaction of collagen with serum complement: inhibition of complement-mediated hemolysis. | Collagens from various vertebrate tissues were tested for their ability to consume complement (C) activity upon incubation in human serum or with isolated components of complement. 10 of 12 collagens tested had anticomplementary activity. The heat-denatured form of collagen, gelatin, was found weakly anticomplementary,... | 166,040 | [
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0.26329,
0.1229285,
0.2129081,
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... |
Muscle fiber and motor end plate involvement in the extraocular muscles of the myotonic mouse. | The extraocular muscles of the C57BL/6Jdy-2j myotonic mouse were studied by phase and electron microscopy. The most susceptible ocular muscle was the levator palpebrae; the other muscles manifested scattered abnormalities to varying degrees. Central nucleation and fiber splitting were prominent. Junctional abnormalitie... | 166,048 | [
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0.5319563,
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0.0570949,
... |
Effects of 5-fluorouracil on exocrine glands. III. Fine structure of Brunner's glands of rats. | Effects of a pyrimidine analogue, 5-fluorouracil (Fur), have been studied by electron microscopy and by electron microscopic cytochemical techniques. Previous studies have demonstrated that rats show serious gastrointestinal disturbances 5 days after 3 daily injections of FUR (50 mg/kg). The present investigation demon... | 166,061 | [
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0.3260313,
0.4298813,
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Adrenal function in hirsutism I. Diurnal change and response of plasma androstenedione, testosterone, 17-hydroxyprogesterone, cortisol, LH and FSH to dexamethasone and 1/2 unit of ACTH. | ACTH dependency of plasma androstenedione (A) and testosterone (T) was determined in normal and hirsute women by measuring the magnitude of change of A and T between the time of the cortisol (F) peak and F nadir in a diurnal study. There was a significant diurnal rhythm of A synchronous with F in both normal and hirsut... | 166,091 | [
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0.07330299,
0.2914462,
0.2144115,
-0.09335... |
Physiological variation in abundance of oestrogen specific high-affinity binding sites in hypothalamus, pituitary and uterus of the rat. | High-affinity binding of [2,4,6,7-3-H]oestradiol-17 beta has been studied in cytosols prepared from hypothalami, pituitaries and uteri of female rats killed at different stages of the oestrous cycle, and in cytosols prepared from the hypothalami and pituitaries of male rats. In all cases the equilibrium dissociation co... | 166,131 | [
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0.1852714,
0.2426758,
0.3532781,
-0.06907018,... |
Development of parthenogenetic membranes in double-yolked and injected chicken eggs. | Development of parthenogenetic eggs is expressed in a Dark Cornish stock by either membrane or embryo formation. Double-yolked eggs have membranes developing in zero, one, or two yolks. The incidence of double-yolked eggs with two membranes was higher than expected when compared with the incidence of single-yolked eggs... | 166,142 | [
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0.4654033,
0.2480531,
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... |
The physiological function of nitrate reduction in Clostridium perfringens. | Fermentation-balance studies have been carried out on Clostridium perfringens grown in the presence and absence of nitrate in the medium. Nitrate is able to serve as an electron acceptor for these bacteria, permitting increased growth yields over those obtained in its absence. This increase is due to an increase in the... | 166,143 | [
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0.1987381,
0.1044403,
0.27271,
0.3523221,
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-... |
Timed-release depot for anticancer agents. | The timed-release of anticancer agents from composities with poly (lactic acid) was studied in rats. In the case of cyclophosphamide-poly (lactic acid) composites, 67% of the administered dose was released within 34 days. With cis-dichlorodiammineplatinum (II), the amount of drug released was only 9.3% within the same ... | 166,155 | [
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0.3257309,
0.4290987,
0.4216249,
0.2058747,... |
Behavior modification approach in a partial day treatment center. | Since the beginning of the program in September 1970, we have found that a combined behavioral program of individual therapy, home intervention, and group therapy to be the most effective for maintaining a person in his community. In addition, we have not seen a need for a full eight-hour day in the clinic. Rather, we ... | 166,169 | [
-0.140177,
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0.1591028,
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0.04449871,
0.09195819,
-... |
Clinicopathologic characterization of Herpesvirus saimiri malignant lymphoma in New Zealand white rabbits. | Twenty-two of 39 rabbits inoculated with Herpesvirus saimiri developed malignant lymphoma and either died or were killed between 17 and 165 days after inoculation. No clinical signs were present in animals developing the disease before 46 days, but all other rabbits had a severe conjunctivitis, nasal discharge, and dys... | 166,191 | [
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0.2120819,
0.04792034,
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0.3017723,
0.0935400... |
R-type virus-like particles in avian sarcoma virus-induced rat central nervous system tumors. | Morphologically distinct virus-like particles (VLP), similar to R-type VLP, were observed by electron microscopy in experimental rat central nervous system tumors induced with the B-77-C strain of avian sarcoma virus (ASV). R-type VLP have a characteristic internal radial structure and were observed previously only in ... | 166,194 | [
-0.1295148,
0.1976977,
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0.4186726,
0.05625963,
... |
[The value of pyrophosphate scintigraphy for the assessment of the activity of spondylarthritis ankylopoietica (author's transl)]. | Seriological and scintigraphic activity was compared in 29 patients with spondylarthritis ankylopoietica (Bechterew's disease). Among our cases, 11 serologically active patients also had positive scans. the details being: cervical vertebral column in 5, thoracic vertebral column in 7 cases and the lumbar vertebral colu... | 166,299 | [
0.04339544,
0.09326015,
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0.3216972,
0.1512263,
0.453064,
0.5949854,
0.1851197,
0.0905355... |
Hyperornithinemia, hyperammonemia, and homocitrullinuria associated with decreased carbamyl phosphate synthetase I activity. | Six subjects from three sibships with hyperornithinemia, homocitrullinuria, and hyperammonemia are described. Assays of liver biopsy in one showed decreased CPS I and leukocyte assays indicate a similar defect in all six. Loading studies with ornithine and citrulline are consistent with a block early in the urea cycle ... | 166,348 | [
-0.1610009,
0.0003168252,
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0.08941697,
0.2007315,
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0.1976676,
0.2003982,
0.2763843,
0.... |
A comparative study of iodine and potassium perchlorate metabolism in the laying hen. 1. incorporation of I-131 in chicken ova. | The uptake of 131-I in chicken ova was studied for 3 hours after a single intramuscular dose. There was uptake as early as 10 minutes and it continued throughout the 3 hours in spite of a rapid decrease in blood activity. The fast growing ova, weightin 0.5 to 2.0 grams, were the most efficient in the uptake of 131-I ... | 166,365 | [
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0.1345998,
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0.00784722,
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0.0242825,
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0.09741111,
0.1051351,
0.2214404,
0.001735564,
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0.2317745,
0.3483799,
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0.1854257,
0.2340698,
0.09780663,
-... |
[The clinical value of contrast-less mammography in endocrine diseases]. | The authors analyze the X-ray picture of the changes occurring in the mammary glands in women with various endocrine diseases and in men with gynecomastia. Contrastless mammagraphy was carried out in 189 persons. In studying the mammagrams in patients with endocrine diseases assessment was made of the state of the su... | 166,370 | [
-0.01990371,
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0.1212744,
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0.1597839,
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0.6089671,
-0.03244807,
0.05662... |
Methylated simian virus 40-specific RNA from nuclei and cytoplasm of infected BSC-1 cells. | Host cell and virus-specific poly(A)-containing RNAs isolated from nuclei and cytoplasm of monkey kidney cells infected with simian virus 40 contain different methylated nucleotides. In the cytoplasmic simian virus 40-specific RNA, about 75% of the radioactivity derived from (methyl-3-H)methionine was in N-6-methyladen... | 166,375 | [
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0.6186361,
0.01911149,
-0.1181323,... |
Properties of cytoplasmic mutants of Saccharomyces cerevisiae with specific lesions in cytochrome oxidase. | Two mutants with specific defects in cytochrome c oxidase (ferrocytochrome c:oxygen oxidoreductase; EC 1.9.3.1) have been isolated from cultures of Saccharomyces cerevisiae exposed to the mutagens ethyl-methane sulfonate and Mn++. The mutations have been shown to be extranuclear by two criteria. The phenotype persists ... | 166,377 | [
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0.1589756,
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0.5123049,
-0.0837... |
Neutron scattering study of human serum low density lipoprotein. | Regions of different proton density in the low density lipoprotein (LDL) particle from human serum have been determined by neutron scattering. From measurements in various H2O/D2O mixtures, the LDL particle appears to be quasi-spherical, with the centers of gravity of the hydrocarbon and polar regions coinciding. The a... | 166,382 | [
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0.08130586,
0.1978166,
0.09579094,
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0... |
Action of luteinizing hormone-releasing hormone and synthesis of prostaglandin in the pituitary gland. | The possibility that prostaglandin E2 (PGE2) may play a role in luteinizing hormone (LH) release was examined using an in vitro model. Addition of luteinizing hormone-releasing hormone (LH-RH) to the culture medium stimulated cyclic AMP accumulation and LH-release by incubated hemipituitaries, but did not affect the le... | 166,417 | [
-0.07875048,
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0.1228258,
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0.07652483,
0.3852017,
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0... |
Pseudorabies virus - induced neural hyperreactivity following occular and skin infections in the rat. | The types of functional disturbances caused by a neurotropic virus was investigated by means of neurophysiological techniques. Two types of neurophysiologic lesions were produced in the superior cervical sympathetic ganglia and sural nerve in rats infected with two distinct strains of pseudorabies virus. The pruritus-p... | 166,421 | [
-0.1830993,
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0.4205003,
0.2962125,
0.1988042,
0.100765,
0.16... |
Induced adhesion in Crassostrea virginica larvae. | Normal motile veliger larvae of the oyster, Crassostrea virginica, were observed swimming in pairs or trios. Adhesion between animals is firm and has a specific orientation. This adhesion can be induced in low frequencies by culturing larvae at high densities, and in much higher frequencies by inclusion of an antibioti... | 166,435 | [
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0.4040574,
0.001967488,
-0.0... |
[2 cases of hepatorenal polycystosis]. | The authors report two cases of polycystic liver andkidney in two women. They were unusual in that the liver first gave risr to symptoms and the renal lesions were completely latent. Both hepatic and renal lesions were well tolerated in spite of hepatomegally. They emphasize the interest of laparoscopy and biopsy of th... | 166,438 | [
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0.2415664,
0.06695272,
0.09738033,
0.1028251,
-0.2447896... |
Ultrastructural-morphometric analysis of the rat prostate (ventral lobe). | A morphometric model, which provides information on the structure of the normal gland (ventral lobe) has been developed for the rat prostate. The model consists of morphologically defined space and membrane compartments, which are used to describe the specific components of the protein and enzyme synthesizing and secre... | 166,474 | [
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0.3151335,
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0.4129532,
0.009123516,
0.0494611... |
[Study of glycogen metabolism in the liver in type III glycogenosis (limit dextrinosis)]. | Data on biochemical study of a patient with glycogenosis of the III type (limit dextrinosis) are presented. In a punctate of liver tissue absence of amylo-1,6-glucosidase activity and significant accumulation of glycogen, which was anomalous in structure, were noted. Loading with galactose and adrenaline caused alterat... | 166,513 | [
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0.06476631,
0.03718282,
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0.4963312,
0.01203506,
0.0552... |
A study on the influence of papovavirus upon encephalitis caused by SSPE agent. | To investigate a possible interaction between the SSPE agent and papovaviruses, histopathological and statistical evaluations were made of encephalitis induced in hamsters by intracerberal inoculation with isolates from SSPE and PML patients, and with BK virus, alone or in combination. With SSPE virus alone, hamster br... | 166,547 | [
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0.3745231,
0.09460221,
0.2528043,
0.1025182,... |
Experimentally induced malakoplakia. | Malakoplakia was induced experimentally by introducing large amounts of crude endotoxin-antigen comples of 075 Escherichia coli (E. coli 12797 CDC 0 group 75) into the kidneys and testes of rats. First leukocytes, then granulation tissue composed mainly of characteristic macrophages, the so-called Hansemann cells, appe... | 166,563 | [
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0.08808313,
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0.07609594,
0.1868649,
0.3242827,
0.4351194,
0.03933214,
0... |
Seizure activity and anticonvulsant drug concentration. | Current methods permit frequent, accurate serum anticonvulsant drug concentration measurements and continuous, 24-hour electroencephalographic recording with minimal environmental restriction. These techniques were used to perform longitudinal, 24-hour recordings of electroencephalographic paroxysmal activity and sleep... | 166,630 | [
0.06870718,
0.1081239,
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0.08401193,
0.2747118,
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0.04838088,
0.02717812,
-... |
Phosphorylation of the lysine-rich histones throughout the cell cycle. | The phosphorylating of the lysine-rich histone at various stages in the cell cycle has been studied. In rapidly dividing cell populations the lysine-rich histone is phosphorylated rapidly after synthesis and more slowly once bound to the chromosome. The half-life of hydrolysis of such interphase phosphorylation in 5 hr... | 166,660 | [
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0.06631813,
0.5280773,
0.3698627,
0.008231666,
... |
EPR studies on the respiratory chain of wild-type Saccharomyces cerevisiae and mutants with a deficiency in succinate dehydrogenase. | 1. Three nuclear mutants of Saccharomyces cerevisiae deficient in succinate dehydrogenase have been isolated. Two of these mutants are allelic. 2. The amount of covalently bound flavin of submitochondrial particles of the two allelic mutants is about 14% and that of the third mutant about 50% of the amount in wild-type... | 166,668 | [
-0.2202443,
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0.06354288,
0.2587928,
0.5783705,
0.1556226,... |
Spin label evidence for the role of lysoglycerophosphatides in cellular membranes of hibernating mammals. | The phospholipid composition of ground squirrel heart muscle changes during hibernation: more lysoglycerophosphatides are found in the hibernating state than in the active state. Phase transitions inferred from spin label motion occur in the usual manner typical of mammalian mitochondria for the mitochondria and mitoch... | 166,691 | [
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0.0421331,
0.04897023,
0.1892795,
0.1458702,
-0.032700... |
The control of anaerobic glycolysis by glucose transport and ouabain in slices of hepatoma 3924A. | 1. The activities of glycolysis and K-+ transport have been studied in slices of Morris hepatoma 3924A incubated under anaerobic conditions in the presence of different concentrations of glucose (1-50 mM). 2. Ouabain-sensitive net transport of K-+ was observed at all glucose concentrations greater than 1 mM; ouabain re... | 166,693 | [
-0.200574,
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0.4818572,
0.1906209,
-0.0415... |
Tissue fractionation in rat brain, kidney and liver. I. Intracellular localization of a 5-methyltetrahydrofolic acid requiring enzyme. | The intracellular distribution of N-methyl-transferase requiring 5-methyl-tetrahydrofolic acid (5 MT-NMT) was studied in brain, kidney and liver of rats. Among these different tissues, the kidney displayed the highest enzyme activity, more than 20 times the activity detected in the brain. As the striatum and, to a less... | 166,705 | [
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0.2012919,
0.4604255,
0.2308062,
0.3958814,
-0.1811521,... |
Effect of chronic marijuana administration of stages of primate sleep-wakefulness. | The effects of the repeated administration of delta-9-tetrahydrocannabinol on sleep-wakefulness patterns were studied in adult male squirrel monkeys. The percent time spent in slow wave sleep was reduced with chronic treatment and failed to return to base line levels after 30 days of recovery. The amount of time spent ... | 166,711 | [
0.1353731,
0.01285755,
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0.1189271,
0.01183328,
0.2072791,
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... |
Electron microscopic findings of cells with inclusion bodies in experimental hemorrhagic enteritis of turkeys. | The spleen, liver, bone marrow and intestines of two turkeys in which hemorrhagic enteritis of turkeys was experimentally reproduced were examined electron-microscopically. Intranuclear inclusion bodies as described in a previous report were found in all the tissues examined. These occupied most of the area in affected... | 166,739 | [
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0.3356072,
0.01534984,
0.2425106,
0.2882613,
-0.00401979... |
Response of hepatic carbohydrate and cyclic AMP metabolism to cadmium treatment in rats. | Daily intraperitoneal injection of cadmium chloride (0.25 or 1 mg/kg) for 21 or 45 days into rats significantly stimulated the activities of hepatic pyruvate carboxylase, phosphoenolpyruvate carboxykinase, fructose-1, 6-diphosphatase, and glucose-6-phosphatase, increased the concentrations of glucose and urea in the bl... | 166,749 | [
-0.3143457,
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0.05685936,
0.1849901,
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-0.04396368,
0.3540199,
-0.2637315... |
Leoprosy- clinical aspectos of nerve involvement. | Leprosy is the cause of the commonest peripheral neuropathy. The predilection of Mycobacterium leprae for nerve tissue accounts for the clinical features that are most dreaded and most characteristic of the disease. Were it not for the progressive destruction of peripheral nerve trunks and the consequences of this, lep... | 166,794 | [
0.07956676,
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0.02491926,
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0.08283331,
0.29144,
0.03010806,
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0.350037,
0.109394... |
Leprosy--histopathologic aspects of nerve involvement. | The most striking single feature of the clinical manifestations of leprosy is the very wide range of appearances shown by the skin lesions. These include the vague, hypopigmented macules of indeterminate leprosy; the large, sharply defined hypopigmented anaesthetic lesions of tuberculoid leprosy; the nodules and diffus... | 166,795 | [
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0.5609103,
0.04845351,
0.003034505,
0.4888451,
0.0442520... |
Red cell enzymes. | As compared to other cells of the body, the mammalian red cell has one of the simplest structural organizations. As a result, this cell has been extensively used in studies involving the structure, function, and integrity of cell membranes as well as cytoplasmic events. Additionally, the metabolic activities of the red... | 166,798 | [
-0.229358,
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0.02761035,
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0.2840504,
0.3639548,
0.2108269,
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... |
Contraceptive steroid binding to the human uterine progesterone-receptor. | Using an equilibrium dialysis method, the competition was investigated between tritated-progesterone and a range of synthetic steroids for binding to 20,000 g. supernatants of human uterine endometrium and myometrium. Both types of uterine tissue showed similar patterns of progestogen binding and probably contain simi... | 166,800 | [
-0.3014019,
0.1936294,
0.0837897,
0.2116424,
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0.1065689,
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0.3263873,
0.2710622,
0.2567154,
0.01532681,
0.10495... |
A method for determination of the specific activity of receptor-bound human chorionic gonadotropin (hCG). | Precise knowledge of the specific activity (S.A., muc/mug) of the receptor bound radiolabelled hormone is required for study of the stoichiometry of peptide hormone-receptor interactios. A radioligand receptor assay using 131-I-hCG as tracer and transplantable mouse luteoma homogenates (Biol. Reprod. 8:550, 1973) as a ... | 166,818 | [
-0.2171173,
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0.1205703,
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0.3070413,
0.4887105,
0.1752166,
0.08575964,
-... |
Stimulation of division of Y1 adrenal cells by a growth factor isolated from bovine pituitary glands. | The effect of Fibroblast Growth Factor (FGF) on the initiation of DNA synthesis and on the rate of division of the Y1 adrenal cell line has been investigated. In sparse populations of Y1 cells (4 times 10- minus 3 cells/cm2) maintained in 0.2 percent calf serum, FGF was able to initiate DNA synthesis to the same extent... | 166,822 | [
-0.02159143,
-0.07128247,
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0.1601789,
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0.3966793,
0.5556464,
-0.2335107,
-0.2789945... |
The effect of LH/FSH, dibutyryl cyclic AMP, and prostaglandins on the production of estrogens by rabbit granulosa cells in vitro. | The purpose of this study was to establish the effects of trophic hormones on the production of estrogens by rabbit granulosa cells. A pure population of these cells was isolated from preovulatory follicles (1-15 mm in diameter) of estrous rabbits, and cultured for 6 days with either one or a combination of the followi... | 166,823 | [
-0.08454205,
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0.07881062,
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0.2846397,
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0.005554237,
0.3487971,
0.2364894,
-0.02875174,
-0.1605474,
... |
Effects of TSH on iodide transport by mouse thyroid lobes in vitro. | Thyroidal iodide concentration by in vitro mouse thyroid lobes was studied by determining the equilibrium tissue/medium iodide, concentration ratio (T/M[I-]), THYROIDAL I- influx, and thyroidal I-efflux in the presence and absence of ClO4-. Chronic thyroid stimulation by low dietary iodine increased the T/M[I-], and th... | 166,827 | [
-0.4775878,
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0.1502386,
0.08784363,
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0.02853724,
0.1560925,
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0.1028852,
0.2131375,
-0.05808242,
0.0553526... |
The effect of dietary rape-seed oil on cholesterol-ester metabolism and cholesterol-ester-hydrolase activity in the rat adrenal. | The effects of stock diet and stock diet supplemented by olive oil and rape seed on rat adrenal cholesterol ester metabolism have been studied. Rats fed rape seed oil failed to gain weight at the same rate as rats fed olive oil. A prominent feature of the rats fed rape seed oil was an accumulation of high concentration... | 166,839 | [
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0.2832361,
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0.1685739,
0.06012513,
0.1049762,
0.3498827,
-0.321943,
0.2077043,
-0.2890621,
0.01855719,
0.06192385,
0.2934016,
0.5725642,
0.1418891,
-0.09762529,
... |
The detection of the Epstein-Barr virus (EBV) nuclear antigen (EBNA) by anticomplement immunofluorescence. Immunoglobulin class of antibodies and role of complement. | The Epstein-Barr virus (EBV)-associated nuclear antigen (EBNA) was detected by anti-complement immunofluorescence (ACIF) in Raji lymphoblastoid cell line, and the mechanism of the reaction explored, using Ig fractions of anti-EBNA sera and purified components of complement. Following fractionation of serum from 13 dono... | 166,939 | [
0.03059426,
-0.1570206,
0.1349803,
0.0668507,
0.5361543,
0.0589745,
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0.2518761,
0.1975037,
0.4262514,
0.0129234,
0.1608024,
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0.05024329,
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0.196693,
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0.2274176,
0.359622,
-0.1852304,
-0.2590357,
0.04154... |
Interference of pregnancy steroid hormones with FPN test for estimation of phenothiazine derivatives in urine. | Interference of pregnancy steroid hormones with FPN test for estimation of some phenothiazine derivatives in urine has been investigated. The FPN test was positive in 97.9% of urine samples obtained from pregnant women. It is supposed that metabolites of estrogens and progestagens present in higher amounts in urine sam... | 166,958 | [
-0.126701,
0.1886068,
0.09665952,
0.02662916,
0.1574022,
0.0003362637,
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0.09889373,
0.1182741,
0.05440634,
0.4174891,
0.0216825,
0.1233625,
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0.3291797,
-0.007694166,
0.1301769,
-0.07320263,
-0.01932407,
-0.12095... |
Multiple forms of cytochrome b in Mycobacterium phlei: kinetics of reduction. | The kinetics of reduction of the b-type cytochromes in the electron transport particles (ETP) from Mycobacterium phlei were studied with nicotinamide adenine dinucleotide, reduced form (NADH) or succinate as electron donors. There appeared to be three active cytochromes b in the ETP,bS563 and bS559, which were reducibl... | 166,977 | [
-0.2457175,
0.1313287,
0.1123843,
0.3517694,
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-0.4484466,
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0.3365013,
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0.2300476,
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0.1502855,
0.08985216,
0.3376403,
-0.05825416,
0.... |
Mechanism of the isomerization of isopentenyl pyrophosphate in Rhodotorual rubra-1. | Stereospecifically labeled mevalonic acid was incorporated into the carotenoids of Rhodotorula. The randomized results are discussed in relation to mechanisms proposed for the conversion of isopentenyl pyrophosphate to dimethylallyl pyrophosphate and the prenol transferase enzyme system to Rhondotorula rubra. | 166,981 | [
-0.07552409,
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0.1525056,
0.1946187,
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0.08512198,
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0.2283506,
0.0202825,
0.1738073,
0.4169187,
0.3048539,
0.06286208,
-0.... |
Electron paramagnetic resonance and water proton relaxation rate studies of formyltetrahydrofolate synthetase-manganous ion complexes. Evidence for involvement of substrates in the promotion of a catalytically competent active site. | Conformational properties of the active site of formyltetrahydrofolate synthetase from Clostridium cylindrosorum have been examined by EPR spectroscopy and by solvent proton relaxation rate (PPR) studies of manganous complexes with the enzyme. Ternary enzyme-Mn-nucleotide complexes give EPR spectra which are very simil... | 166,989 | [
0.04884931,
-0.3336241,
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0.03648802,
0.3517219,
0.2280362,
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0.2361109,
0.1752535,
0.4097607,
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-0.4537284,
0.193884,
-0.2984565,
0.2972392,
0.3705091,
0.1389927,
-0.06484754,
... |
The role of Ca-2+ and cyclic adenosine 3':5'-monophosphate in insulin release induced in vitro by the divalent cation ionophore A23187. | Insulin release from isolated perifused pancreatic islets was stimulated by the divalent ionophore A23187 in the absence of exogenous glucose. In addition, A23187 produced a 2-fold elevation of cyclic adenosine 3':5'-monophosphate (cAMP) levels in isolated perifused islets. The elevation of cAMP levels coincided with p... | 166,996 | [
-0.2635213,
-0.3403906,
-0.3944981,
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0.2689051,
0.02499726,
0.1825321,
0.3420604,
-0.1124655,
0.2057547,
-0.00343844,
-0.06801365,
-0.1872127,
0.05848901,
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-0.1715794,
-0.3119875,
0.06457269,
0.4214345,
0.02659875,
0.07124171,... |
Rapid identification of amino acid derivatives from the sequenator. | A simple procedure is described for converting thiazolinones, from the protein sequenator, to the more stable phenylthiohydantoins without using the conventional HCI conversion procedure. The thiazolinones are applied to a silica gel plate and converted to phenylthiohydantoins by heating at 140 for 5-10 min, in the pre... | 167,051 | [
0.1631804,
0.1404399,
0.1221431,
-0.3445687,
0.09055591,
-0.2148477,
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0.2886698,
0.3901259,
0.05521338,
0.08865821,
0.0582546,
0.2682905,
-0.3404342,
-0.2031448,
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-0.3258553,
0.1646585,
0.109607,
0.2173385,
-0.09233911,
0.1068747,
-0.1032291,
0.151... |
Analysis for organophosphorus insecticides and metabolites. | Extraction and cleanup methods used for the analysis of organophosphate pesticides are similar to those used for chlorinated hydrocarbons but differ in some important details. Many organophosphates are lost during extraction of acetonitrile solutions containing organophosphates with petroleum ether; dichloromethane is ... | 167,052 | [
0.1007672,
0.381871,
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0.07397524,
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-0.2869531,
0.3002428,
-0.08778571,
0.1121634,
0.0361287,
-0.1368604,
-0.2899104,
-0.002321748,
-0.3189401,
-0.1296853,
-0.655756,
0.4771727,
0.1395572,
0.4700438,
-0.07032573,
0.1880506,
-0.2885416,
... |
Transport of dietary cholesterol into blood and milk of the goat. | Position 4 labeled carbon-14 cholesterol was placed in abomasums (stomachs) of two lactating goats. Blood and milk samples were collected from the animals for 5 to 13 days. Specific activities of cholesterol and cholesteryl esters in various fractions of blood serum and milk were determined to reveal pathways by which ... | 167,066 | [
-0.3556489,
0.3150139,
-0.1128305,
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0.08564086,
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0.07003908,
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0.1380073,
0.0799054,
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-0.5488924,
-0.0501317,
0.0725945,
0.1212577,
0.4053688,
0.294185,
-0.0231813,... |
The pituitary-adrenal system of the genetically obese (ob/ob) mouse. | Adult genetically obese (ob/ob) mice which are characterized by adrenal hypertrophy and increased secretion of corticosteroids have considerably increased levels of ACTH in the pituitary gland. At 5 weeks of age there is no difference in the pituitary ACTH content of lean and obese animals and dietary restriction, suff... | 167,093 | [
0.001732707,
-0.09314843,
-0.05984572,
0.1570159,
0.178954,
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0.2313549,
0.001973664,
-0.09117169,
0.1054665,
0.05238861,
-0.005113861,
0.2083096,
0.09058097,
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-0.001207933,
0.1598112,
0.1584547,
0.2050036,
0.3829833,
-0.07273805,
0.009627061,
-0.1664... |
Ultrastructural aspects of BK virus uptake and replication in human fibroblasts. | After exposure of human embryonic fibroblasts to BK virus, virus particles adsorbed to the plasma membrane were engulfed by pinocytosis or captured by vesicles, possibly originating from the endoplasmic reticulum, within 2 h after infection. Most of the virus particles were then transported into lysosomes or into the n... | 167,108 | [
-0.5574415,
0.09059575,
0.1467466,
-0.01635889,
0.2127286,
-0.3356744,
-0.2131144,
-0.08092764,
0.1859017,
0.4062235,
0.1087295,
-0.2302154,
-0.111212,
0.02880753,
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-0.1064015,
0.08036934,
0.3598192,
0.1486964,
0.3665586,
0.3171576,
0.07207061,
-... |
Location and abundance of poly (A) sequences in Sendai virus messenger RNA molecules. | Adenine-rich sequences from 18S Sendai virus messenger RNA species were 99% adenylate, 3'-OH terminal, and were present in at least 50% of the RNA molecules. Intact virus messenger RNA molecules were resistant to exonucleolytic attack by polynucleotide phosphorylase, suggesting that their 3'-termini are masked. | 167,113 | [
-0.1067544,
0.06645108,
-0.3118982,
-0.02317618,
0.1343117,
-0.110766,
-0.1503865,
-0.0641906,
0.1861043,
0.02436946,
0.1054315,
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0.1072408,
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0.1597235,
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0.0385162,
0.241046,
0.2125054,
0.3406627,
-0.06368608,
-0.1682737,
-... |
The lact of antiviral effect of (polyinosinic acid): (polycytidylic acid) when attached to insoluble supports. | A local antiviral effect can be observed when (poly rI)-(poly rC), bound to Visking discs by u.v. irradiation, is incubated with monolayers of human foreskin fibroblast cells. Radioactive labelling of cytosine residues in (poly rI)-(poly rC) with -125I, has provided a much more sensitive method for determining the fate... | 167,121 | [
-0.06384134,
0.06820905,
0.07898084,
0.2066215,
0.3873087,
-0.130508,
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0.2231903,
0.2855945,
0.1504049,
0.2953952,
0.1217971,
0.134068,
0.08135939,
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-0.2848615,
0.05472691,
0.2011779,
0.2775747,
0.6072054,
0.1175313,
-0.2657923,
-0.25130... |
Continuous intraventricular cerebrospinal fluid pressure recording in hydrocephalic children during wakefulness and sleep. | Continuous 24-hour recordings of intracranial pressure and electroencephalographic activity were made on five hydrocephalic children in whom, in the resting wakefulness state, the intracranial pressure (ICP) was considered normal. An increase in both the mean ICP and its oscillations related to cardiac systole was reco... | 167,135 | [
-0.2122542,
-0.09445712,
-0.3868814,
-0.4805048,
0.0999127,
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-0.3045053,
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-0.1573706,
0.1527488,
0.2388926,
0.3490173,
-0.4680158,
-0.1267315,
-0.1108401,
-0.01936062,
-0.5102831,
0.1901099,
-0.165673,
0.001949678,
-0.01451615,
-0.2373643,
0.04102942,... |
The sensitivity of adrenal responses to synthetic adrenocorticotrophin in the conscious unrestrained calf. | 1. Changes in cortisol and corticosterone output and blood flow from the adrenal gland have been determined in the conscious unrestrained calf during I.V. infusions of synthetic adrenocorticotrophin (Synacthen) at 0-5 ng-kg(-1) min- minus 1 (low dose), 5 ng-kg- minus 1 (medium dose), 50 ng-kg- minus 1 min- minus 1 (hig... | 167,157 | [
-0.1500466,
0.05286407,
-0.3530967,
-0.4128296,
0.03502394,
-0.2860648,
-0.334713,
-0.001267865,
0.01637784,
-0.1198076,
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-0.2251314,
0.2255222,
-0.08012979,
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-0.1860012,
-0.3537472,
0.2078656,
0.08841931,
0.5448851,
0.1307708,
-0.006435215,
0.10172... |
Evidence for the existence of protomers in the assembly of encephalomyocarditis virus. | Two capsid precursor subunits, which sediment on glycerol gradients at 13S and 14S, respectively, have been identified in cytoplasmic extracts of encephalomyocarditis virus-infected HeLa cells. The 13S subunit, which was detected after a 10-min pulse label with -3H-labeled amino acids, contained only capsid precursor c... | 167,183 | [
-0.6026644,
0.1329981,
-0.5516251,
0.05897821,
0.274332,
0.03086922,
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0.144444,
0.07792197,
-0.2052601,
0.1218053,
0.2865573,
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-0.01038318,
-0.2369654,
0.4703227,
0.5026841,
0.1116094,
-0.2088927,
-... |
Post-transcriptional restriction of human adenovirus expression in monkey cells. | Infection of the continuous simian cell lines CV-1 and BSC-1 with human adenovirus type 2 (Ad2) is abortive. However, the restriction of Ad2 reproduction in these cells can be overcome by increasing the Ad2 infectious dose or by coinfection with simian virus 40. Vero, another established simian cell line free of detect... | 167,185 | [
-0.1096548,
0.04449067,
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0.3672666,
-0.1975237,
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0.3974924,
-0.0483991,
-0.09394503,
-0.1392484,
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0.2936511,
-0.1915161,
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-0.4615754,
-0.09889192,
-0.1812876,
0.1362794,
0.3997993,
0.285619,
-0.05707171,
... |
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