title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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[Radiophotographic detection in evaluation of the incidence of tuberculosis]. | In a territory with a population of over 120,000 inhabitants, of which 86% in rural environment, with a high tuberculosis endemic rate, four integral detections were organized in 12 districts and three in the other 12 base units of the area between 1969 and 1973. In most of the districts the incidences varied, in the y... | 171,745 | [
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Studies on human serum high-density lipoproteins (HDL). IV. Isolation of lipoprotein families after incubation of HDL. | The high-density lipoproteins (HDL) of human serum appear to be unstable and easily exposed to chemical changes during isolation. In earlier studies we have isolated and purified HDL subfractions either in the presence of an SH-blocking agent, DTNB, or in the cold. By both procedures reproducible lipoprotein subfractio... | 171,762 | [
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Isolated partial deficiency of adrenocorticotrophic hormone. | A patient with tuberculous empyema who presented with severe hyponatraemia, is described. In the course of investigation, he was discovered to be suffering from isolated adrenocorticotrophic hormone deficiency. | 171,777 | [
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Identification and successful treatment of congenital microfistulas with the aid of directional Doppler. | Hitherto unidentifiable and therefore untreatable congenital microfistulas were detected with the aid of continuous-wave directional Doppler and a fine-beam pencil probe. The microfistulas formed part of the Klippel-Trenaunay (K-T) syndrome. The management of one case is reported in detail and in three others salient f... | 171,785 | [
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Serological study of amebiasis and toxoplasmosis in the Lindu Valley, Central Sulawesi, Indonesia. | Results of a serology survey in April 1972 for Entamoeba histolytica and Toxoplasma gondii antibodies among 484 inhabitants of the isolated Lake Lindu Valley of Central Sulawesi (Celebes) are presented. Indirect hemagglutination antibody titers for amebiasis were found in over 10% of the population, although only 3.7% ... | 171,809 | [
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[Role of the virus of Aujeszky's disease in respiratory diseases of swine]. | Studies carried out on pig-breeding farms have established the presence of Aujeszky's disease virus in cases of bronchopneumonia in pigs. On seven out of eight farms with bronchopneumonia the virus wad demonstrated both virologically and serologically, and nearly 50 per cent of the examined diseased pigs on these and o... | 171,824 | [
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Increasing occurence of tumour cell -- tumour cell emperipolesis in the regenerating JB-1 ascites tumour. | During the investigation of JB-1 ascites tumour cells in recurrent growth several cases of emperiopolesis were observed. Different types of emperipolesis are presented. Light microscopical serial sections, autoradiography and transmission electron microscopy indicate that the cells involved in emperipolesis are separat... | 171,869 | [
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[Fibrillar and tubular fine structures in the cytoplasm of Entamoeba histolytica (author's transl)]. | The electron-microscopical study of conventional fixed and contrasted Entamoeba histolytica-trophozoites from Diamonds monoxenic TTY-medium revealed "thick fibrils" in the vesicular cytoplasm of the parasites. They are 9-14 nm in diameter and are therefore considered to be myosin-like filaments, that are spread mainly ... | 171,874 | [
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Hybridization of mouse leukemia virus c-DNA to mouse repeated DNA sequences. | Experiments of hybridization between mouse leukemia virus synthetic 3H-DNA probe and mouse main band and satellite DNAs indicate that there is not a higher concentration of viral sequences in the satellite DNA. On the contrary, viral sequences appear to be enriched in the fast renaturing intermediate main band DNA. | 171,901 | [
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Liver, lung and malignant disease in heterozygous (Pi MZ) alpha1-antitrypsin deficiency. | Theoccurrence of PAS-positive, diastase-resistant, inclusion bodies in hepatocytes has been used as a marker of heterozygous (Pi MZ) alpha1-antitrypsin deficiency in order to study the frequency of lung, liver and malignant disease in a consecutive autopsy material from a well defined population. Typical PAS-positive i... | 171,917 | [
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Effect of Ca++ on renal handling of PO4 identical to: evidence for two reabsorptive mechanisms. | The effect of hypercalcemia on renal handling of phosphorus was studied in parathyroidectomized rats during 1) extracellular volume expansion with normal saline (0.1 mg/100 g per min) and 2) parathyroid extract infusion (1 U/100 g per h). Hypercalcemia (serum calcium 12-15 mg/100 ml) blunted the phosphaturic response t... | 171,963 | [
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The fine structure of the urinary bladder epithelium in the hartebeest, Alcelaphus buselaphus cokii and the Masai giraffe, Giraffa camelopardalis tippelskirchi. | The microscopic anatomy and ultrastructure of the urinary bladder epithelium are described in the giraffe and the hartebeest. Differences between the epithelial cell layers of the urinary bladder are described. Cells belonging to different layers show variations in their cell organelles and inclusions. The surface cell... | 171,975 | [
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The isolation of epithelial cells from the rat epididymis. | Epithelial cells from the epididymis were released by digesting the chopped epididymis with pronase followed by collagenase plus hyaluronidase. The epithelial cells were further separated from contaminating cell types by differential centrifugation and sedimentation at unit gravity through a gradient of sucrose in Ring... | 171,976 | [
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Thermostability of duck hepatitis virus. | The comparative thermostability of 4 duck hepatitis (DH) viruses were tested at various temperatures for different times. Titer of duckling-passaged, pathogenic DH virus decreased from 10(4.50) to 10(2.33) and 10(2.20) median infective doses (ID50/0.1 ml, respectively, in 2 tests; titer of chicken embryo-passaged, nonp... | 171,986 | [
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[Juvenile hormone in diapausing Pieris brassicae and mutations. Tetrahydrofolic acid and pterins incubated in chrysalids, provoking ontogenic and mutagenic genetic information alterations in Drosophila melanogaster]. | Study of AMPc phosphodiesterase shows presence of JH in diapausing chrysalids and antogonistic action of FH and pterines. Study of farnesoldeshydrogenase and farnesal deshydrogenase in Dm shows that FH4 and pterines inhibite FDH, active ADH. Conclusion is JH in diapause chrysalides is active factor with FH4 provoking g... | 172,004 | [
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Desmosome-like structures in the cytoplasm of normal human keratinocyte. | Desmosome-like structures in the cytoplasm which have so far been described in tumoral and acantholytic epidermal cells were observed on two occasions in morphologically normal basal and prickle cells. It seems that under specific conditions a normal epidermal cell can lose contact with the surrounding cell during cell... | 172,032 | [
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[Electron microscopy studies on proliferation of foot-and-mouth disease virus in cell cultures. I. Morphologic changes in cell nucleus]. | The first morphological indication of FMD infection of a cell culture was in the nucleus. Components of nucleoli became segregated and were finally present only as remnants. It was not possible to distinguish different stages of segregation, as in the case of entero-virus infections, because of the rapidity of FMD viru... | 172,041 | [
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Acute ocular infection by type 2 herpes simplex virus in adults. | Acute ocular infections in two adults were caused by type 2 herpes simplex virus (HSV) ("genital herpesvirus"). One patient had an acute blepharoconjunctivitis, the other an acute keratoconjunctivitis. Genital infections had preceded the eye infections, and type 2 HSV was isolated from the eyes of both patients and fro... | 172,050 | [
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Maintenance of DNA and repair of Apurinic sites. | Escherichia coli cells contain an enzyme which hydrolyzes a phosphodiester bond near each apurinic site in double-stranded DNA. This endonuclease is specific for apurinic sites; it has no effect on normal DNA, and its action on alkylated DNA is restricted to apurinic sites. In vitro incubation with the endonuclease for... | 172,058 | [
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Isolation and identification of products from alkylation of nucleic acids: ethyl- and isopropyl-purines. | Ethylation and isopropylation of guanine in alkaline solution, or of adenine in formic acid, by alkyl methanesulphonates gave the following products: 1-, N2-, 3-, O6-, 7- and 9-alkylguanines; 1-, 3-, 7- and 9-alkyladenines. The products were identified from their characteristic u.v-absorption spectra, by comparison wit... | 172,066 | [
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The contribution of atrial stretch receptors to salt and water homeostasis in the human. | Studies carried out in both the human and experimental animals provide reasonably strong evidence that receptors contained within the atria are involved in the control of body water. When atrial pressure is increased (and the atria distended) atrial receptor discharge is increased leading to an increase in urine flow a... | 172,063 | [
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A method for investigating the effect of temperature on the 695 nm band of insoluble cytochrome c. | A method is described for computer analysis of simple spectrophotometric changes in particulate systems, and this has been applied to the bleaching of the 695 nm band of insoluble ferricytochrome c by temperature. The results show that insolubilization has no effect on the standard enthalpy change but lowers the value ... | 172,068 | [
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Connective tissue activation. IX. Modification by pharmacologic agents. | Alpha- and beta-adrenergic blocking agents and imipramine inhibit the increased hyaluronate synthesis that may be induced in human synovial cultures by connective tissue activating peptide (CTAP). Considerations of drug concentration requirements, actions of analogues, and time studies all indicate that the adrenergic ... | 172,091 | [
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In vivo microscopic observations of the pathogenesis of acute mouse viral hepatitis. | In vivo microscopy of the liver was undertaken to determine the extent of involvement of the hepatic microvascular system in mice infected with viral hepatitis (MHV-3). It was found that the major effects of the disease were produced in localized areas where parenchyma, sinusoids and blood were obliterated. However, im... | 172,100 | [
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Is the cyclic AMP in psoriatic epidermis low? | A deficiency of epidermal cyclic adenosine 3', 5'-monophosphate (cyclic AMP) has been implicated as the cause of the incomplete differentiation, increased mitosis and increased glycogen concentration which characterize the psoriatic lesion. This communication contains our data on the epidermal concentration of cyclic A... | 172,103 | [
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Sodium periodate modification of factor VIII procoagulant activity. | Chemical treatment of human factor VIII by sodium periodate resulted in increased levels of procoagulant activity when measured by the two-stage assay. Increased levels of factor-VIII activity were observed following periodate treatment of factor-VII concentrates and normal, haemophilic and von Willebrand's disease pla... | 172,113 | [
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Primary carcinoma of stomach with uterine metastasis. | Curettings from a 42-year-old woman who suffered from heartburn, weight loss and irregular vaginal bleeding showed apparently metastatic mucoid adenocarcinoma in the endocervix. The primary site of tumour was not evident. At laparotomy a gastric adenocarcinoma was found and total hysterectomy with bilateral salpingo-oo... | 172,115 | [
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Quantitative aspects of hormone-receptor interactions of high affinity. Effect of receptor concentration and measurement of dissociation constants of labeled and unlabeled hormones. | It is demonstrated that because of limitations in the magnitude of the specific activity of radiolabeled hormone derivatives, direct binding studies of hormone-receptor interactions of high affinity (10(-9) -10(-11) M, depending on whether 3H- or 123I-labeled hormones are used) will be subject to artifactual distortion... | 172,127 | [
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0.1648487,
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0.01146985... |
Respiratory control in isolated perfused rat heart. Role of the equilibrium relations between the mitochondrial electron carriers and the adenylate system. | The effects of KCl-induced cardiac arrest on the redox state of the fluorescent flavoproteins and nicotinamide nucleotides and on that of cytochromes c and a were studied by surface fluorometric and reflectance spectrophotometric methods. These changes were compared with measurements of the concentrations of the adenyl... | 172,132 | [
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0.255162,
0.02031212,
... |
Collagenolytic activity of carrageenin granuloma in rats. | Collagenolytic activity at various phases of the development of carrageenin granuloma was investigated by measuring the amount of dialysable hydroxyproline formed during incubation in vitro of minced granulation tissue. Collagenolytic activity reached a maximum at day 8 after carrageenin injection and then decreased gr... | 172,140 | [
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0... |
Comparison of the secretory processes in the parotid and sublingual glands of the mouse. 1. Regulation of the secretory processes. | 1. Secretion from the mucous sublingual gland of the mouse has been investigated and compared with the serous parotid gland. The influence of acetylcholine, noradrenalin and adrenalin on the secretion of glycoproteins (e.g. mucins) and proteins (e.g. amylase) from these glands in vitro, and the involvement of cyclic AM... | 172,149 | [
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0.5412511,
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-0.04332... |
Partial characterization of the 1-anilino-8-naphthalene sulfonate-adrenochrome semicarbazide interaction site in erythrocyte ghost membrane fragments. | The effect of adrenochrome semicarbazide on the conformation of erythrocyte ghost membranes has been studied by ANS fluorescence, lipid and sulfhydryl spin labels and circular dichroism. No large conformational alterations in the membrane were detected by these techniques. Noncompetitive quenching of ANS fluorescence b... | 172,164 | [
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[Propagation of spikes in statistical neuron ensembles. I. Concept of phase transitions]. | A system of two coupled integro-differential equations for the propagation of sipkes is presented. A qualitative consideration of the system shows possibility of concentrational phase transition in the neuron ensemble from the state of spontaneous firing to the strong periodic oscilltation activity. Naer the point of t... | 172,161 | [
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... |
[Basis for the use of Pierre's method for the determination of ACTH in human blood plasma]. | Adrenal glands of rats were immersed in Ringer-Lock solution (used as control), other rat adrenal glands were immersed in human blood plasma. The amount of corticosterone in the extracts received was estimated after two hours of incubation. The activity of adrenocorticotropic function of the pituitary gland of the pati... | 172,167 | [
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0.0742615... |
[Cytological aspects of various particular varieties of breast epitheliomas]. | Needle aspiration for cytological investigation has been used at the Foundation Curie since 1954. Until 1973, no less than 3,176 mammary tumours have been studied by this method and comparison made with the histological findings. In the whole group some relatively rare carcinomas have been encountered -- mucoid, medull... | 172,171 | [
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0.8958316,
-0.4144064,
0.0593955... |
Incidence of Herpesvirus hominis antibodies among blood donor populations. | The microneutralization test was used to determine the occurrence of antibodies to Herpesvirus hominis Type 1 and Type 2 in sera from patients attending the Special Clinic, Bristol Royal Infirmary, with proven herpes genitalis, and in sera taken from blood donors in Bath, Dursley, and Bristol, as well as from donors in... | 172,191 | [
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0.2467722,
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... |
Immunochemical studies of the surface and cytoplasmic membranes of Entamoeba invadens (Rodhain 1934). | The antigenic properties of cell fractions prepared from axenically grown Entamoeba invadens were investigated using various immunoelectrophoretic methods. All membrane fractions displayed varying degrees of antigenicity, the most predominant being a cytoplasmic light-vesicle fraction. The surface membrane showed the l... | 172,203 | [
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0.3722516,
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Electron microscopy of vesicular-arbuscular mycorrhizae of yellow poplar. II. Intracellular hyphae and vesicles. | Intracellular hyphae and vesicles in mycorrhizal roots of yellow poplar were examined by electron microscopy. An investing layer of host wall material and cytoplasm enclosed the endophyte within the cells. Young developing hyphae contained abundant cytoplasm and few vacuoles. As hyphae matured, they became highly vacuo... | 172,206 | [
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0.2034471,
0.6341983,
0.1168781,
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Influence of formycin B on polyadenosine diphosphoribose synthesis in vitro and in vivo. | Formycin B inhibited growth of L5178Y mouse leukemia cells in concentrations of less than twice the concentration that inhibits cell proliferation at 50% by cytostasis; at higher concentrations (more than twice the 50% concentration mentioned), the cells were killed. In cells treated with the concentration that inhibit... | 172,231 | [
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0.03105289,
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... |
[Identification of cAMP dependant protein kinases in human lymphocytes]. | Chromatographic purification by "DEAE" cellulose resolves the cAMP binding proteins in human lymphocytes into three parts. In presence of Mg++ each one possesses cAMP dependent protein-kinase activity, one of them showing allosteric characteristics. | 172,248 | [
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[RNA fragments rich in G and A nucleotides obligatory for in vitro DNA replication of phages phi-X 174 and lambda]. | Evidence was presented that in vitro conversion of single-stranded DNA of phage phi X 174 to the double-stranded replicative form by partially purified DNA-dependent DNA polymerase I requires a specific RNA fragment acting as primer (25-50 nucleotides). RNA fragments highly rich in nucleotides A and G were obtained by ... | 172,251 | [
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-0.1512... |
[Effect of antioxidant substances on the level of free organic radicals naturally present in the rat diaphragm]. | Using the electron spin resonance method, the effect of antioxydants on the number of natural organic free radicals is studied in the case of the diaphragm of the Rat. The effect observed shows an important decrease in the free radical concentration, which may, in the case of ascorbic acid and BHT, lead to their comple... | 172,254 | [
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The radiology of excavated Saxon and medieval human remains from Winchester. | Radiography of many of the human bones discovered during the archeological excavations at Winchester has been an integral part of the study of the Saxon and medieval populations found there. Thus, a radiological study of bone pathology in successive populations from a single site spanning a period of 600 years is prese... | 172,275 | [
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Regulation of enzymes of serine and one-carbon metabolism by testosterone in rat prostate, liver, and kidney. | A significant decrease in the specific activity of 3 enzymes of serine and one-carbon metabolism (3-phosphoglycerate dehydrgenase, phosphoserine phosphatase, and serine hydroxy-methyltransferase) was found in the rat prostate gland with castration. A single injection of testosterone propionate to rats 3 days after cast... | 172,314 | [
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0.4244063,
0.2609771,
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... |
A direct effect of testosterone on muscle cells in tissue culture. | A direct effect of physiological levels of testosterone on skeletal muscle cells in tissue culture is reported. The effect is a 25% stimulation of labeling index by radioautographic analysis of cultures following incubation with [3H]thymidine at the end of a 48-h exposure to 10(-8)M testosterone in 2% gelding serum. Th... | 172,315 | [
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0.2275726,
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0.5506886,
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... |
[Synthesis and properties of semisynthetic penicillins containing the furoxan nucleus]. | Synthesis, antibacterial activity and stability in acid solution of potassium salts of 6-(3-methyl-4-furoxancarboxyamido)penicillanic acid and 6-(4-methyl-3-furoxancarboxyamido)penicillanic acid are reported. | 172,370 | [
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Histochemical studies on the albino rat pancreas in different periods following vagotomy and simultaneous pyloromyotomy. | The effect of complete subphrenic vagotomy and simultaneous pyloromyotomy on the morphological state and the activities of some intracellular enzymes of the albino rat was studied histochemically. Within the first weeks after vagotomy, the pancreatic acini were found to diminish in size, and the beta-cells in the islet... | 172,415 | [
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0.05099985,
0.06924541,... |
Correlation between various cell-surface antigens induced by murine leukemia virus in the rat: serological analysis. | Analysis based on the cytotoxicity test using antisera produced in rats indicated the presence of various cell-surface antigens on the tumors in WKA/Mk rats induced or artificially infected by Friend, Rauscher or Gross viruses. Each line of the tumor was found to have a common antigen, namely group-specific cell-surfac... | 172,420 | [
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0.09842649,
0.257888,
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... |
Organ culture of human nervous system tumors. | Tumors of the human nervous system (neuroblastomas, an ependymoma, a medulloblastoma, and a Schwannoma) obtained during surgery have been cultured organotypically by the method of Wolff. The tumors retained characteristic morphology, organization and patterns of behavior in vitro, and one neuroblastoma gave rise to a g... | 172,438 | [
-0.04958103,
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0.111418,
0.4797638,
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-0.05533459,... |
Fine structural and cytochemical studies of human diploid fibroblasts arrested in an essentially nonmitotic state. | Human diploid fibroblasts can be maintained in vitro in an arrested, essentially nonmitotic state for extended periods of time by reducing the serum concentration in the medium from 10 to 0.5%. Arrested cells can be induced to re-enter the proliferative state by subcultivation in medium containing 10% serum. Fine struc... | 172,440 | [
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-... |
Viral replication and interferon production in fetal and adult ovine leukocytes and spleen cells. | Peripheral blood leukocyte and spleen cell cultures derived from adult sheep and from third-trimester (107 to 145 days of gestation) and second-trimester (70 to 98 days of gestation) fetal lambs were examined for their ability to support viral replication and to produce interferon. Bluetongue virus, Herpesvirus hominis... | 172,452 | [
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0.1211961,
0.2409378,
0.4030662,
-0.275474... |
Septamycin, a polyether antibiotic. Taxonomy, fermentation, isolation and characterization. | Septamycin is a metal complexing polyether antibiotic produced by a strain of Streptomyces hygroscopicus NRRL 5678. The metabolite, a monocarboxylic acid, was isolated as the sodium salt C48H81NaO16. The crystal structure and absolute configuration were established by X-ray analysis of the p-bromophenacyl derivative. S... | 172,482 | [
-0.4010039,
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-0.009903247,
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0.3800063,
0.2272228,
0.1173318,
-0.1351... |
Binding and degradation of 125I-insulin by rat hepatocytes. | The binding and the velocity of degradation of 125I-insulin in the absence or presence of varying concentrations of native procline insulin were studied using isolated rat hepatocytes. At insulin concentrations ranging from 5 X 10(-11) to 10(-6) M, insulin degradation velocity showed a first order dependence on the tot... | 172,497 | [
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0.2516294,
0.001313215,
-... |
Effect of serum on phenylalanine hydroxylase levels in cultured hepatoma cells. | Continued high levels of phenylalanine hydroxylase in cultured H4-II-E-C3 rat hepatoma cells require either serum or glucocorticoids in the culture medium. Upon withdrawal of serum, cellular phenylalanine hydroxylase levels decay exponentially with a half-life of 22 hours for about 60 hours, after which time a low, con... | 172,500 | [
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0.5466661,
-0.01637414,
0.2496399,
-0.2601618... |
Role of carbohydrate of human chorionic gonadotropin in the mechanism of hormone action. | The role of the carbohydrate part of human chorionic gonadotropin (hCG) was investigated by measuring the ability of hCG derivatives lacking various sugar residues to bind to rat Leydig cells and stimulate them to synthesize testosterone and cyclic adenosine 3':5'-monophosphate (cyclic AMP). Whereas sequential removal ... | 172,504 | [
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-0.5327761,
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-0.1510601,
0.05152666,
0.4418156,
0.04683661,
-0.1062937... |
Membrane-associated thiamin triphosphatase. II. Activation by divalent cations. | Activation of membrane-associated thiamin triphosphatase from rat brain requires a divalent cation (Mg2+, Ca2+, or Mn2+). The optimum concentration of Mg2+ necessary for maximal enzyme activity varies with substrate concentration; conversely, the maximal rate of hydrolysis attainbale by increasing thiamin triphosphate ... | 172,510 | [
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0.3064534,
0.4028475,
0.2054504,
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0.279... |
Biogenesis of microsomal membrane glycoproteins in rat liver. I. Presence of glycoproteins in microsomes and cytosol. | The glycoproteins of microsomes and cytosol were studied. Various washing procedures did not release the proteins from the microsomes, and immunological tests demonstrated that the sialoproteins are not serum components. Low concentrations of deoxycholate and incubation in 0.25 M sucrose solution liberated a small amou... | 172,515 | [
-0.02660625,
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0.03614665,
0.3737278,
0.1376399,
-0.1258161,
-0... |
The role of adenosine 3',5'-monophosphate in the transformation of Cloudman mouse melanoma cells. | The role of adenosine 3',5'-monophosphate (cyclic AMP) in the regulation of mouse melanoma cell growth and differentiation was investigated. A variant melanoma (Cloudman S91-F) which displays a greater degree of transformation than the parental cell (Cloudman S91) was isolated. A correlation between cyclic AMP metaboli... | 172,519 | [
-0.169414,
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0.6075038,
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0.1730099,
0.2248712,
0.6570403,
-0.178824,
-0.4827683,
0.13... |
Metabolism of apoprotein B of plasma very low density lipoproteins in the rat. | As an extension of metabolic studies of the cholesteryl ester component of rat very low density lipoproteins, we have studied the metabolism of the B apoprotein component labeled by intravenous injection of [3H]lysine. The B apoprotein separated from other apoproteins by delipidation and selective precipitation with te... | 172,530 | [
0.009649828,
0.4577149,
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0.2648108,
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0.0443674,
-0.1134153,
0.1165687,
0.2575559,
0.01690696,
... |
High-pressure liquid chromatography: separation of the metabolites of vitamins D2 and D3 on small-particle silica columns. | The high-pressure liquid chromatographic separation of all of the known metabolites of vitamin D(2) and vitamin D(3) found in biological fluids has been achieved. This technique has been successfully applied to the analysis of vitamin D mixtures, purification of vitamin D metabolites, and identification of radioactive ... | 172,574 | [
-0.09756849,
0.1368017,
0.1530113,
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0.107069,
0.3022301,
0.1828157,
0.2867324,
0.1987627,
-0.2923163,
0.... |
Modification of myometrial activity in vivo by administration of cyclic nucleotides and theophylline to the pregnant rat. | Myometrial activity was recorded in vivo in unrestrained pregnant rats from day 19 of gestation using radiotelemetry. The effects of short-term infusions of theophylline, dibutyryl cyclic AMP and 8-bromo-cyclic GMP were investigated. All three compounds caused a decrease in oxytocin-induced, prostaglandin F2alpha-induc... | 172,577 | [
0.0004821937,
0.0881118,
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0.0451139,
0.1957076,
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0.1746162,
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0.004794226,
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0.05604298,
0.06703441,
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0.07367612,
-0.3368305,
0.02753723,
0.3403547,
0.1229272,
-0.0437266... |
Sodium chloride transport by rabbit gallbladder. Direct evidence for a coupled NaCl influx process. | The results of the present study that NaCl transport by in vitro rabbit gallbladder must be a consequence of a neutral coupled carrier-mediated mechanism that ultimately results in the active absorption of both ions; pure electrical coupling between the movements of Na and Cl can be excluded on the grounds of electrphy... | 172,595 | [
-0.3153613,
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-0.6978741,
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-0.1585731,
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0.4080201,
-0.09353496,
0.1... |
Genes involved in the uptake and catabolism of gluconate by Escherichia coli. | The isolation and properties of a mutant of Escherichia coli K12 that is totally unable to take up and utilize gluconate are described. Genetical analysis shows this phenotype to be associated with two lesions. One phenotype, designated GntM-, is the result of a mutation in a gene co-transducible with malA; the other, ... | 172,599 | [
-0.1932103,
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0.04451668,
0.1658011,
-0.1243751,
0.3040186,
0.1100941,
-0.262... |
Distribution of membrane-bound cyclic AMP-dependent protein kinase in plasma membranes of cells of the kidney cortex. | Renal cortical plasms membranes were separated by free flow electrophoresis into luminal (brush border microvilli) and contraluminal (basal-lateral membrane) fractions. These membranes were found to contain an intrinsic, self-phosphorylating system which consists of a cyclic AMP-dependent protein kinase, a phosphorprot... | 172,638 | [
-0.1548323,
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-0.11999,
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0.6331528,
0.07531631,
-0.1630797,
... |
tRNA's associated with the 70S RNA of avian myeloblastosis virus. | The distribtuion of various amino acid tRNA's in the 4S RNA components of avian myeloblastosis virus (AMV) and in 4S RNA prepared from chicken cmbryo cells, chicken myeloblasts, and chicken livers was determined. This was done by aminoacylating the 4S RNA samples with a mixture of 17 radioactive amino acids and subsequ... | 172,660 | [
-0.0464853,
0.03481056,
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0.3559966,
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0.07358876,
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0.3216424,
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0.108535,
0.005532396,
0.2234795,
0.4945272,
-0.1321616,
-0.2482193,
... |
Effects of drugs and axotomy on acetylcholine levels in central cholinergic neurons. | Administration of cholinergic nuscarinic agonists either did not alter, or increased hippocampal Ach levels, while antagonists lowered the levels. As observed previously, placement of lesions in the medial septal area resulted in a rise in hippocampal Ach levels in the first thirty minutes. Agonist drugs administered i... | 172,807 | [
0.2209719,
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0.0349043,
0.04877933,
0.1212249,
0.1708496,
0.01260342,
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0.1580904,
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0.2474622,
0.1457181,... |
Scotomatous defects in the central visual field in pituitary adenomas. | In a series of 46 cases of pituitary adenomata (34 solid, 6 with yellow cyst, and 6 with hemorrhagic cyst), we found central scotomatous field defects in 8 patients. Of these 8 scotomatous cases 4 were associated with tumour containing a hemorrhagic cyst. We suggest that rapid expansion of the tumour is one of the prin... | 172,816 | [
-0.07976626,
-0.005021417,
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0.226104,
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0.2045424,
0.1247517,
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0.03242711,
0.221991,
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0.1275371,
0.1078679,
-0.0309799... |
Demonstration of human leukocyte degranulation induced by sera from homozygotes and heterozygotes for cystic fibrosis. | The ability of epsilon-amino caproic acid (EACA)-treated normal serum and of cystic fibrosis (CF)-affected and carrier sera to promote the release of lysosomal enzymes from sensitized human polymorphonuclear leukocytes (PMN) was assessed through the measurement of beta-glucuronidase and myeloperoxidase activity after e... | 172,851 | [
0.02839449,
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0.1638769,
0.07864391,
0.007228117,
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0.3107376,
0.2391472,
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0.1553009,
0.2791756,
0.01839165,
-0.1427174,... |
Seroepidemiologic survey of varicella: Value of specific fluorescent antibody test. | The sensitive varicella-zoster fluorescent antibody to membrane antigen (V-Z FAMA) test was used in a seroepidemiologic survey of two outbreaks of varicella involving 30 children. The attack rate of varicella based on clinical observations alone was 60%. The attack rate based on clinical and serological observations la... | 172,853 | [
0.08504299,
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0.1398584,
0.001817709,
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0.1384673,
0.353425,
0.3152288,
0.4118872,
0.3461881,
-0.2309994,
0.00... |
Pulmonary infections after kidney transplantation. | Seventy-five pulmonary infections out of 173 kidney transplantations have been observed in 62 graft-recipients, from 1965 to 1973. The aetiologic organism is a bacteria in 80% of the cases, a fungus in 8% of the cases, cytomegalovirus and Pneumocystis Carinii in 11% of the cases. A close relationship between infection... | 172,885 | [
0.01647087,
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0.2645968,
0.3486103,
0.2101329,
0.003785665,
0.08... |
Control of oscillating glycolysis of yeast by stochastic, periodic, and steady source of substrate: a model and experimental study. | Type and range of entrainment of glycolytic oscillations by a periodic source of substrate are determined experimentally in yeast extracts. Subharmonic entrainment proves the nonlinear nature of the glycolytic oscillator Random variation of the substrate input yields sustained oscillations of irregular waveform and sta... | 172,886 | [
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0.2733898,
0.2367346,
-0.2601006,
0... |
Biosynthesis of mouse interferon by translation of its messenger RNA in a cell-free system. | A fraction of mouse RNA containing messenger RNA coding for mouse interferon was translated with high efficiency in a wheat germ system into a fully active product. This product fulfills the criteria for mouse interferon, namely: (1) it was active against vesicular stomatitis virus and herpes simplex virus in mouse cel... | 172,890 | [
-0.07605679,
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0.2028543,
0.3155765,
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-0.1742466,
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-0.2861337,
0.06370156,
0.5440702,
-0.1066768,
-0.2413... |
Anatomy of herpes simplex virus DNA: evidence for four populations of molecules that differ in the relative orientations of their long and short components. | Intact DNA molecules extracted from HSV-1 (herpes simplex virus 1, human herpes virus 1) strain MP virions have a molecular weight of approximately 97 X 10(6), but cleavage with the HinIII restriction enzyme yields fourteen fragments with summed molecular weights of 160 X 10(6). Six "major" fragments occur once in ever... | 172,900 | [
0.01260475,
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0.07627805,
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0.3077268,
0.2606825,
0.1379778,
0.1115626,
-0.2780413,... |
Increases in paradoxical sleep as a result of amygdaloid stimulation. | Holtzman rats were partially and selectively deprived of paradoxical sleep (PS) for a 16 1/2 hr period and allowed to rest for a 7 1/2 hr period each day. Test animals were given mild (60 Hz, 50 muA) unilateral amygdaloid stimulation for one min each day of a 5 day test period. There was a significant increase in PS du... | 172,925 | [
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0.1398603,
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0.1074195,
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-0.09880594,
-0.01824292,
0.2607678... |
Neuroendocrine effects of haloperidol therapy in chronic schizophrenia. | The neuroendocrine effects of haloperidol therapy have been examined in 62 male chronic schizophrenic patients, aged 16-62 years. The duration of the disease varied between 2 and 29 years. The patients were divided into 48 hebephrenics with onset of the disease at puberty, or immediately after puberty, and 14 paranoids... | 172,929 | [
-0.1074395,
-0.3337729,
-0.07843514,
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0.1040315,
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0.2187436,
-0.4570586,
0.2015445,
0.2417277,
0.08044504,
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0.03127047,
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0.3477067,
-0.08039037,
0.1473643,
0.3398706,
0.116712,
0.1901262,
-... |
In vivo studies of parainfluenza I (6/94) virus: mononuclear cell interactions. | Adsorption to and penetration of migratory mononuclear cells in vivo by Para-influenza I (6/94) virus were documented by electron microscopy during the acute phase of an experimental meningoencephalitis in ICR mice. Phagocytosis of virions was the apparent and predominant mode of viral entry into these cells. Penetrati... | 172,948 | [
-0.3393484,
-0.1867168,
-0.1312796,
-0.03517963,
0.2061581,
-0.2117396,
-0.3366159,
-0.2404655,
-0.2464368,
-0.1772054,
-0.05527271,
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0.090522,
-0.08200583,
-0.8923283,
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-0.2232071,
0.07726931,
-0.273858,
0.1734412,
0.1311649,
0.03794058,
0.0872644... |
Experimental immunosuppression induced by herpes simplex virus. | Cell-mediated immune response was studied in experimental herpetic infection in mice. Our data suggest that herpes simplex virus induced immunosuppression in mice. This depression was documented by the unresponsiveness of the lymphocytes to PHA stimulation in vitro and by the enhanced susceptibility of adult mice to Co... | 172,950 | [
-0.1385641,
-0.5595198,
-0.2816713,
-0.08570956,
0.2750326,
0.001871472,
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0.01063064,
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0.1915625,
0.004939289,
0.2908995,
0.2521102,
0.06656969,
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0.03386758,
0.3515425,
-0.2068537,
0.5916675,
0.1122335,
-0.06063774,
0.09740334... |
Isolation of herpes simplex virus clones and drug resistant mutants in microcultures. | Suitable dilutions of herpes simplex virus (HSV) preparations inoculated into microcultures of confluent monolayers of human foreskin or Vero cells, in individual wells of plastic "microplates", induced viral cytopathic effects that resulted from the infection of the cultures by single virus particles. The clonal natur... | 172,951 | [
-0.02325235,
-0.2104576,
-0.1639571,
0.06434493,
0.537947,
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-0.3663116,
0.3056374,
0.3951727,
0.07166617,
0.3571895,
0.08747585,
-0.217686,
0.03693667,
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0.1516442,
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0.4091122,
0.5525265,
-0.091017,
-0.06364728,
... |
[Physiopathological and neuropathological study of a cerebral decortication syndrome]. | Detailed observation of a case of laminar necrosis of almost the whole of the cerebral cortex has led to several deductions concerning the physiology of the cortex in man. It suggests that the cortex has a limited influence on sleep, interfering particularly in the electro-encephalographic translation of slow sleep and... | 173,006 | [
0.0235094,
0.1557847,
0.006483867,
0.02364157,
0.1794513,
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-0.3747979,
0.03468449,
0.1742696,
-0.05732489,
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0.1212315,
0.01746318,
0.252718,
0.09784418,
-0.1403549,... |
Virologic studies in rheumatoid arthritis. | Comparison of virus antibody titers in JRA and matched controls failed to implicate rubella, measles, parainfluenza type 1 or Epstein-Barr viruses. Neither RNA viruses or mycoplasma were detected in rheumatoid synovial cell cultures by 3H-uridine incorporation. Mycoplasma were not isolated from rheumatoid synovial memb... | 173,010 | [
-0.2222816,
-0.3943914,
-0.1374799,
-0.2062722,
0.05648106,
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0.09242854,
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0.2107048,
0.06621126,
0.4816286,
0.2990741,
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0.03394542,
0.1204852,
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0.2387209,
0.7041073,
-0.3017329,
0.07357094,
... |
Metabolism of dehydroepiandrosterone by hormone dependent and hormone independent human breast carcinoma. | The metabolism of 7alpha-3H-dehydroepiandrosterone was studied in six human breast carcinomas in vitro. All mammary tumors transformed DHA to testosterone, dihydrotestosterone, 5alpha-androstane-3alpha, 17beta-diol and 5alpha-androstane-3,17-dione. Of the tumors investigated, three estrogen receptor-negative tumors con... | 173,046 | [
-0.2169001,
-0.008571385,
-0.2133769,
-0.3653694,
-0.1226818,
-0.1520424,
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0.3626247,
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0.2760746,
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0.1525264,
0.1136292,
0.1374256,
0.6794708,
0.3000563,
-0.09500787,
0... |
[Abdominoanal resection of the rectum with a lowering of different sections of the left half of the colon]. | In tumor localization at the level of 7--12 cm aside from the anus the authors performed 168 abdominoanal resections of the rectum with descending of different portions of the left colon. Among these patients in 126 subjects descending of the sigmoid in the anal canal was performed, in 30 of the splenic angle of the tr... | 173,069 | [
0.06034541,
-0.02051308,
-0.2517847,
-0.255625,
-0.02391663,
-0.2954985,
-0.1146399,
-0.09378379,
0.059321,
0.13071,
0.2115865,
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0.1870402,
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-0.005793838,
0.004154283,
-0.001844409,
0.448297,
0.05555275,
-0.0501212... |
[Functional state of the adrenal cortex in patients with cancer of the rectum]. | The level of 17-ketosteroids and 17-ketogenic steroids in the diurnal urine was determined in 70 patients with rectal cancer prior to and after ACTH administration. In most patients the initial excretion of the steroids under study was found to be decreased. 17-ketosteroids excretion is reduced more frequently in patie... | 173,085 | [
-0.03802667,
0.01962553,
-0.4809481,
-0.2382448,
0.0006765604,
-0.4023192,
-0.2597183,
-0.002146683,
-0.007773835,
-0.1043787,
0.1414156,
-0.1972514,
0.2581428,
-0.1150835,
-0.6520554,
-0.210242,
-0.09870017,
0.1259984,
0.09910984,
0.2676379,
0.5513229,
0.09534634,
0.1361... |
[Diabetogenic and atherogenic effects of glucose]. | Tests were set up on 59 albino male-rats with reproduced functional overstress and depletion of the insular system of the pancreas thorough a long-term (for 50, 100 days) peroral introduction of glucose (2 g/100 g body weight, every other day) and with and alloxan-induced diabetes (achieved by poisoning the animals wit... | 173,088 | [
-0.1428948,
-0.02351016,
-0.09298768,
-0.03973971,
0.2924977,
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0.04319188,
0.08970976,
0.2737594,
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0.1267384,
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0.2281757,
0.3530628,
0.4659055,
0.3679108,
-0.05870596,... |
[Comparative studies of simultaneous intraoperative frozen sections and imprint cytology of the mamma (author's transl)]. | 250 tissue biopsies of the mamma were examined simultaneously by intraoperative histology (frozen sections) and imprint cytology. In 95% of the cases there was a good agreement between the histologic and cytologic diagnoses. The reliability of the imprint cytology was tested in some complicated cases such as proliferat... | 173,104 | [
-0.2146518,
-0.2013918,
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0.243068,
0.2916581,
0.2019591,
0.120012,
0.07285242,
0.09904169,
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0.2251183,
0.5594779,
-0.09401513,
-0.2395918,
0... |
[Disorders in conditioned reflex activity and morphologic changes in the brains of rats deprived of paradoxical sleep]. | Reproduction of defensive conditioned reflexes elaborated before a 96-hour deprivation of paradoxal sleep (DPS) in rats was sharply disturbed immediately after DPS, but became normal 24 hours later. Elaboration of conditioned reflexes immediately after DPS is followed by a disturbance of their reproduction, while such ... | 173,108 | [
0.1122175,
-0.06153943,
-0.1354777,
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0.1664425,
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0.08250652,
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0.2472786,
0.1801525,
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0.1304168,
0.1021961,
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-0.3815045,
0.2391777,
-0.1193993,
0.1573854,
-0.04299913,
-0.03153969,
0.1477374,
... |
Double encephalitis with herpes simplex virus and cytomegalovirus in an adult. | A 51-year-old housewife developed symptoms of a cold followed by high fever, delirium, coma, rigidity of extremity muscles, positive Babinski sign and generalized convulsions, while complement-fixing antibody titre to herpes simplex virus in the sera raised over 128 X and declined to 8 X in the course. She finally expi... | 173,128 | [
0.186265,
0.2510205,
0.02546398,
-0.3325295,
-0.03358202,
-0.1072325,
0.1444,
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0.2236178,
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0.08783355,
0.194945,
0.4148187,
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0.112788,
0.09940265,
0.2085888,
-0.04226765,
0.06579182,
-0.1582004,
-0.1... |
Histopathological studies on experimentally induced pulmonary adenomatosis in guinea-pig lungs. | The main purpose of our experimental series was to induce, in experimental animals, diffuse pulmonary fibrosis resembling that in human lungs. In the lungs of guinea-pigs injected with a soluble immune complex and continuously exposed to a 40-60 per cent oxygen-rich atmosphere, diffuse pulmonary fibrosis occurred in ma... | 173,137 | [
0.1401659,
-0.1707525,
-0.1930876,
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0.1973949,
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0.07389186,
0.05017063,
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0.001648292,
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-0.2477803,
-0.05431456,
0.09971575,
0.7712473,
0.09215947,
0.0946301,
0.3315906,
-0.331451... |
Endocrinology in cancer of the breast. Status and prospects. | Breast cancer is the result of a multistage carcinogenic process. Initiation, promotion, dependency and autonomy make up a sequence of experimentally distinguishable phases of this process. Progression--the transition from dependency on hormonal support to autonomy--is demonstrable clinically. High-affinity saturatable... | 173,180 | [
-0.05182798,
-0.1171392,
-0.02811829,
-0.5207302,
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0.0140005,
0.05836739,
0.09339878,
0.3085233,
0.06360216,
0.1732078,
-0.1132096,
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-0.2374704,
-0.2407228,
0.3290485,
-0.2137149,
0.2084352,
0.06156067,
-0.1886304... |
Prostaglandin E in cholera toxin-induced intestinal secretion. Lack of an intermediary role. | Prostaglandin E1 (PGE1) and cholera enterotoxin stimulate small-intestine mucosal adenylate cyclase and intestinal secretion of water and electrolytes. The previous suggestion that PGE may mediate cholera-toxin effects was explored in these studies. Closed rabbit jejunal loops were injected in vivo with cholera toxin a... | 173,182 | [
-0.2190349,
-0.4397232,
-0.4104815,
-0.2782688,
0.002330245,
-0.1119666,
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0.07158396,
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0.1329441,
0.1367949,
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0.1465248,
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-0.1598272,
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0.1108405,
0.4111994,
-0.05176891,
0.0947992... |
Evaluation of a possible sex difference in recombination for the ABO-AK linkage. | Thirty-five informative families were scored for linkage between the ABO and AK loci. The recombination fractions were estimated separately in females and males and were compared with values reported in the literature. A 1.33:1 ratio for the female:male recombination fraction was obtained by combining all sources, but ... | 173,186 | [
0.0004166205,
0.004521563,
-0.04447216,
-0.1809097,
0.1089399,
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0.2074315,
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0.008437385,
0.06233185,
0.1351687,
0.3551475,
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0.1734414,
0.06372803,
0.2439335,
0.3697843,
0.1172889,
-0.1282853,... |
Corticosteroids and ACTH are not required for compensatory adrenal growth. | We have tested the hypothesis that unilateral adrenalectomy results in decreased glucocorticoid secretion, reflexly elevated ACTH secretion, and consequently, compensatory adrenal growth. Plasma ACTH and corticosterone and right adrenal weight were measured during the first 10 days after left adrenalectomy or sham adre... | 173,195 | [
0.06476428,
-0.0653448,
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-0.5377174,
0.1524074,
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0.2979744,
0.06931414,
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0.01720683,
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-0.3338681,
-0.1345395,
0.05851944,
-0.10788... |
Hepatic echography. | There are 2 kinds of echographic investigations: those which are only complementary and those which are specific by themselves. To improve this latter category, we would like to emphasize two useful echographic signs. First, the attenuation sign, which indicates the fibrotic nature, therefore practically speaking, the ... | 173,198 | [
-0.1330901,
0.2643387,
-0.06241893,
-0.2367102,
0.1390287,
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0.2164815,
0.3397337,
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0.07555899,
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0.1006323,
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0.1990149,
-0.0119702,
-0.1860037,... |
Equine serum lipids: lipid composition and electrophoretic mobility of equine serum lipoprotein fractions. | The serum lipoprotein fractions from 5 Morgan and 5 Thoroughbred horses were isolated by preparative ultracentrifugation, chemically analyzed for lipid composition, and studied by 2 methods of polyacrylamide gel electrophoresis to determine electrophoretic mobility. Breed differences were not seen in the relative perce... | 173,211 | [
-0.06677796,
0.3135928,
-0.1241662,
-0.250188,
0.06141759,
-0.4375167,
0.04510867,
0.1532824,
0.0206313,
0.01875618,
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0.1489224,
0.1726529,
0.09557205,
0.01437262,
0.1101056,
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0.04846261,
0.1131663,
-0.0990025,
0.149552,
0.2008712,
-0.236386,
-0.1... |
[Peripheral neuropathies i- Waldenstrom's disease. Histological and ultrastructural studies of 5 cases]. | In four cases it was the existence of peripheral neuropathy which led to the discovery of macroglobulinemia within an interval from 1 to 11 years. The treatment of the disease also markedly improved the peripheral neuropathy in three cases. Two patients died. Two of the biopsies of the peripheral nerve showed infiltrat... | 173,209 | [
-0.4417729,
-0.09194388,
0.04324456,
0.1380017,
0.07391568,
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0.276288,
0.1756876,
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0.2472046,
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-0.01552429,
-0.01948781,
-0.2239555,
0.2948896,
0.3461358,
0.02421357,
0.1373004... |
Carcinofetal alterations in glycogen phosphorylase isozymes in rat hepatomas. | As part of a continuing study on the loss or retention of enzymes involved in specific hepatic functions in a series of rat liver neoplasms ranging widely in growth rate and degree of differentiation, isozyme patterns of glycogen phosphorylase in rat hepatomas were compared with those in rat tissues during development.... | 173,229 | [
-0.1599064,
-0.1036852,
-0.3528013,
-0.1890144,
0.4461886,
-0.3339607,
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0.03304383,
0.122075,
0.3826238,
0.2349731,
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0.305049,
-0.2523742,
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0.0455268,
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-0.196565,
0.2169482,
0.05096663,
0.310125,
0.1794416,
-0.06272379,
0.1083... |
[Experimental investigations on the accumulation of radioactive compounds in autochtonal tumors in the rat (author's transl)]. | For the first time results of investigations on rats with radioactive compounds in autochtonal tumors of the central nervous system, induced via placenta by Ethyl-Nitrose-Urea (ENU), are reported. In contrast to transplantation tumors the tumors induced by ENU are comparable in regard to the szintigrafic results with h... | 173,256 | [
-0.3189697,
-0.3467216,
-0.09913801,
-0.1224918,
0.3073299,
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-0.3004759,
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0.231494,
0.3111582,
0.01336101,
0.04269937,
0.3266801,
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-0.6210051,
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-0.4475593,
0.4985133,
-0.3309991,
0.05994815,
-0.09785821,
0.1771078,
-0.125828,
... |
SV40 induced polypeptides in infected and transformed cells. | 5 structural (VP) and 3 non-structural (NSVP) SV40 induced polypeptides which display two kinetic patterns of synthesis are identified in infected cells. NSVP 1 and 2 are "early" functions of which only NSVP 1 is present in transformed cells; NSVP 3 is "late" function which is also present in a line (T-22) of transform... | 173,262 | [
-0.4626604,
-0.1866621,
-0.4618323,
-0.2392232,
0.337944,
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-0.2918897,
0.07731652,
0.1959329,
0.2590702,
0.07903617,
0.03286603,
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0.1335374,
-0.08627997,
0.1379647,
0.3174525,
0.1844544,
-0.1810797,
... |
Variation between electrophoretically identical alleles at the alcohol dehydrogenase locus in Drosophila melanogaster. | A new variant of alcohol dehydrogenase (ADH 7lk) was found in a laboratory stock of Drosophila melanogaster. ADH in this stock had the same electrophoretic mobility as the F variant both on acrylamide and on agar. Activity levels were similar to the levels in F flies at temperature between 15 and 25 C. But while ADH F ... | 173,280 | [
-0.1722039,
-0.02936077,
-0.1778862,
-0.04282322,
-0.01034424,
0.1509759,
0.1023407,
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0.1111154,
-0.2032616,
0.3599702,
0.2428125,
0.139397,
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-0.34199,
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-0.3882681,
-0.06501436,
0.226817,
0.08207145,
0.1669478,
0.1445713,
-0.1538698,
... |
The roles of the infectious bursal agent and several avian adenoviruses in the hemorrhagic-aplastic-anemia syndrome and gangrenous dermatitis. | The effect that breeder-flock immune status regarding the infectious bursal agent (IBA) and two avian adenoviruses (DPI-1 and DPI-2) has on the susceptibility of their commercially reared Delmarva broiler progeny to the hemorrhagic-aplastic-anemia syndrome and concurrent gangrenous dermatitis was determined. Lack of im... | 173,278 | [
0.02924904,
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0.1000644,
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0.1427842,
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0.2152492,
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0.05972316,
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0.3299353,
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0.1276824,
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-0.697035,
0.008511959,
0.1148497,
0.04202467,
0.1751346,
-0.2400187,
-0.3047088,
... |
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