bc5disease/train_1000.json

[
    {
        "id": "1782",
        "type": "disease",
        "text": "The finding of cocaine - induced vasoconstriction in segments of ( noninnervated ) human umbilical artery suggests that the presence or absence of intact innervation is not sufficient to explain the discrepant data involving the possibility of alpha - mediated effects .",
        "entities": []
    },
    {
        "id": "3318",
        "type": "disease",
        "text": "Finally , pruritus disappeared within 19 months , and liver tests returned to normal 27 months after the onset of hepatitis .",
        "entities": [
            "pruritus",
            "hepatitis"
        ]
    },
    {
        "id": "625",
        "type": "disease",
        "text": "Thus , the relationship between cholinergic activity and responsiveness and alcohol withdrawal was investigated in a genetic animal model of ethanol withdrawal severity .",
        "entities": []
    },
    {
        "id": "1024",
        "type": "disease",
        "text": "These responses were blocked by systemic pre - administration of hexamethonium chloride ( 20 mg / kg ) .",
        "entities": []
    },
    {
        "id": "3632",
        "type": "disease",
        "text": "Recurrence was studied in 82 evaluable patients after 1 year of follow - up and in 72 patients followed for 2 - 3 years ( mean 32 months ) .",
        "entities": []
    },
    {
        "id": "2270",
        "type": "disease",
        "text": "No signs of bone marrow depression were found .",
        "entities": [
            "bone marrow depression"
        ]
    },
    {
        "id": "1713",
        "type": "disease",
        "text": "In addition to genetic influences , recent studies suggest that prenatal drug or chemical exposures are risk factors for autism .",
        "entities": [
            "autism"
        ]
    },
    {
        "id": "40",
        "type": "disease",
        "text": "Motor behavior , passive avoidance , and skilled forelimb function were tested repeatedly for six weeks .",
        "entities": []
    },
    {
        "id": "2695",
        "type": "disease",
        "text": "Efficacy and safety of asenapine in a placebo - and haloperidol - controlled trial in patients with acute exacerbation of schizophrenia .",
        "entities": [
            "schizophrenia"
        ]
    },
    {
        "id": "861",
        "type": "disease",
        "text": "Pseudoacromegaly , on the other hand , is the presence of similar acromegaloid features in the absence of elevated growth hormone or insulin - like growth factor levels .",
        "entities": [
            "Pseudoacromegaly"
        ]
    },
    {
        "id": "4141",
        "type": "disease",
        "text": "A minority of anionic sites were scattered throughout the lamina densa and lamina rara interna , and were significantly smaller than those in the lamina rara externa of the glomerular basement membrane ( p < 0 . 001 and p < 0 . 01 for diabetic and control rats , respectively ) .",
        "entities": [
            "diabetic"
        ]
    },
    {
        "id": "1776",
        "type": "disease",
        "text": "In individuals with preexisting , high - grade coronary arterial narrowing , acute myocardial infarction may result from an increase in myocardial oxygen demand associated with cocaine - induced increase in rate - pressure product .",
        "entities": [
            "acute myocardial infarction"
        ]
    },
    {
        "id": "1762",
        "type": "disease",
        "text": "CONCLUSIONS : The administration of methylprednisolone and gentamicin in the posterior sub - Tenon ' s space was related to a high incidence of side effects including nausea , vomiting , and headache .",
        "entities": [
            "nausea , vomiting",
            "headache"
        ]
    },
    {
        "id": "138",
        "type": "disease",
        "text": "In several models of hypertension , elevation of intracellular sodium level was documented in cardiac tissue .",
        "entities": [
            "hypertension"
        ]
    },
    {
        "id": "3689",
        "type": "disease",
        "text": "Beyond 8 days of DES exposure , the immunochemically PRL - positive proportion of cells increased to over 50 % of the total population .",
        "entities": []
    },
    {
        "id": "4191",
        "type": "disease",
        "text": "Four patients who were rendered comatose or stuporous by drug intoxication , but who were not hypoxic , are described .",
        "entities": [
            "comatose",
            "stuporous"
        ]
    },
    {
        "id": "4148",
        "type": "disease",
        "text": "In addition , reflex bradycardia caused by injected norepinephrine was significantly enhanced by L - dopa , DL - Threo - dihydroxyphenylserine had no effect on blood pressure , heart rate or reflex responses to norepinephrine .",
        "entities": [
            "bradycardia"
        ]
    },
    {
        "id": "783",
        "type": "disease",
        "text": "Clinicians should be aware of this potential complication when adding thalidomide to chemotherapeutic regimens .",
        "entities": []
    },
    {
        "id": "613",
        "type": "disease",
        "text": "The administration of ifosfamide was discontinued and within 12 h the asterixis resolved completely .",
        "entities": [
            "asterixis"
        ]
    },
    {
        "id": "2622",
        "type": "disease",
        "text": "We analyzed the following events : complications related with the topical anesthesia , with MZ use and with the procedure .",
        "entities": []
    },
    {
        "id": "3050",
        "type": "disease",
        "text": "Antihypertensive drugs and depression : a reappraisal .",
        "entities": [
            "depression"
        ]
    },
    {
        "id": "1846",
        "type": "disease",
        "text": "Warfarin is the most widely used oral anticoagulant and is indicated for many clinical conditions .",
        "entities": []
    },
    {
        "id": "2040",
        "type": "disease",
        "text": "Proteinuria increased significantly from a median of 0 . 13 g / day ( range 0 - 5 . 7 ) preswitch to 0 . 23 g / day ( 0 - 9 . 88 ) at 24 months postswitch ( p = 0 . 0024 ) .",
        "entities": []
    },
    {
        "id": "2590",
        "type": "disease",
        "text": "The EDITS scores were 67 . 4 ( 10 . 2 ) for the bupropion and 36 . 3 ( 11 . 7 ) for the placebo group ( P = 0 . 001 ) .",
        "entities": []
    },
    {
        "id": "2852",
        "type": "disease",
        "text": "Myelosuppression was more in patients with hepatic dysfunction .",
        "entities": [
            "Myelosuppression",
            "hepatic dysfunction"
        ]
    },
    {
        "id": "349",
        "type": "disease",
        "text": "Patients who are given this drug regimen should be observed very carefully for early signs of nephrotoxicity .",
        "entities": [
            "nephrotoxicity"
        ]
    },
    {
        "id": "870",
        "type": "disease",
        "text": "The duration of the study was six months .",
        "entities": []
    },
    {
        "id": "4244",
        "type": "disease",
        "text": "Risk factors of sensorineural hearing loss in preterm infants .",
        "entities": [
            "sensorineural hearing loss"
        ]
    },
    {
        "id": "3493",
        "type": "disease",
        "text": "Total fasciculation scores in the 30 - mg bolus group and the 5 - mg s - 1 and 20 - mg s - 1 infusion groups were not significantly different .",
        "entities": [
            "fasciculation"
        ]
    },
    {
        "id": "4271",
        "type": "disease",
        "text": "Pregnant rats were administered one of these calcium channel blockers during the period of cardiac morphogenesis and the offspring examined on day 20 of gestation for cardiovascular malformations .",
        "entities": [
            "cardiovascular malformations"
        ]
    },
    {
        "id": "1787",
        "type": "disease",
        "text": "In the present study , we investigated the changes occurring at the protein level in striatal samples obtained from the unilaterally 6 - hydroxydopamine - lesion rat model of PD treated with saline , L - DOPA or bromocriptine using two - dimensional difference gel electrophoresis and mass spectrometry ( MS ) .",
        "entities": [
            "PD"
        ]
    },
    {
        "id": "3652",
        "type": "disease",
        "text": "An autoradiographic study was performed on male F - 344 rats fed diet containing FANFT at a level of 0 . 2 % and / or aspirin at a level of 0 . 5 % to evaluate the effect of aspirin on the increased cell proliferation induced by FANFT in the forestomach and bladder .",
        "entities": []
    },
    {
        "id": "3566",
        "type": "disease",
        "text": "Reduction in caffeine toxicity by acetaminophen .",
        "entities": [
            "toxicity"
        ]
    },
    {
        "id": "2300",
        "type": "disease",
        "text": "The major effect was on dystonia subscore .",
        "entities": [
            "dystonia"
        ]
    },
    {
        "id": "3541",
        "type": "disease",
        "text": "The follow - up period was 12 months .",
        "entities": []
    },
    {
        "id": "1492",
        "type": "disease",
        "text": "METHODS : All patients with a diagnosed cerebral haemorrhage at three hospitals during the period 2000 - 2002 were identified .",
        "entities": [
            "cerebral haemorrhage"
        ]
    },
    {
        "id": "2215",
        "type": "disease",
        "text": "Adverse effects of topical papaverine on auditory nerve function .",
        "entities": []
    },
    {
        "id": "3840",
        "type": "disease",
        "text": "Treatment was from weeks 0 to 8 and was then tapered from weeks 8 to 16 .",
        "entities": []
    },
    {
        "id": "654",
        "type": "disease",
        "text": "Our findings indicate that cocaine induced hyperlocomotion is modified by 5 - HT1B receptor ligands microinjected into the accumbens shell , but not core , this modification consisting in inhibitory and facilitatory effects of the 5 - HT1B receptor antagonist ( GR 55562 ) and agonist ( CP 93129 ) , respectively .",
        "entities": [
            "hyperlocomotion"
        ]
    },
    {
        "id": "1834",
        "type": "disease",
        "text": "BACKGROUND : A 72 - year - old white man with underlying human immunodeficiency virus , atrial fibrillation , coronary artery disease , and hyperlipidemia presented with generalized pain , fatigue , and dark orange urine for 3 days .",
        "entities": [
            "human immunodeficiency virus",
            "atrial fibrillation",
            "coronary artery disease",
            "hyperlipidemia",
            "pain",
            "fatigue"
        ]
    },
    {
        "id": "2274",
        "type": "disease",
        "text": "Alpha - lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy .",
        "entities": [
            "mitochondrial damage",
            "neurotoxicity",
            "neuropathy"
        ]
    },
    {
        "id": "1796",
        "type": "disease",
        "text": "Serum creatinine ( SCr ) levels and estimated glomerular filtration rate were assessed at baseline and 2 to 5 days after receiving medications .",
        "entities": []
    },
    {
        "id": "2882",
        "type": "disease",
        "text": "Mazindol doses not slow the progression of weakness in Duchenne dystrophy .",
        "entities": [
            "weakness",
            "Duchenne dystrophy"
        ]
    },
    {
        "id": "1257",
        "type": "disease",
        "text": "Decrease of fetal length was the only signs of the DFU developmental toxicity observed in pups exposed to the highest compound dose .",
        "entities": [
            "toxicity"
        ]
    },
    {
        "id": "3165",
        "type": "disease",
        "text": "Modest increases in HDL - cholesterol levels of about 10 % are also reported .",
        "entities": []
    },
    {
        "id": "1007",
        "type": "disease",
        "text": "This case suggests that the psychotic symptoms that occur following phenytoin treatment in some epileptic patients may be the direct result of medication , unrelated to seizures .",
        "entities": [
            "psychotic symptoms",
            "epileptic",
            "seizures"
        ]
    },
    {
        "id": "5",
        "type": "disease",
        "text": "METHODS : The cardiovascular responses to standing and head - up tilt were studied repeatedly in PD patients receiving selegiline and as the drug was withdrawn .",
        "entities": [
            "PD"
        ]
    },
    {
        "id": "4163",
        "type": "disease",
        "text": "The nephrotoxic action of anticancer drugs such as nitrogranulogen ( NG ) , methotrexate ( MTX ) , 5 - fluorouracil ( 5 - FU ) and cyclophosphamide ( CY ) administered alone or in combination [ MTX + 5 - FU + CY ( CMF ) ] was evaluated in experiments on Wistar rats .",
        "entities": [
            "nephrotoxic"
        ]
    },
    {
        "id": "1757",
        "type": "disease",
        "text": "METHODS : A double - blind double - armed prospective study comprised 40 patients who had uneventful sutureless phacoemulsification under sub - Tenon ' s local infiltration of 3 mL of plain lignocaine .",
        "entities": []
    },
    {
        "id": "4252",
        "type": "disease",
        "text": "CASE SUMMARY : A 40 - year - old woman with major depression took an overdose of venlafaxine in an apparent suicide attempt .",
        "entities": [
            "major depression",
            "overdose"
        ]
    },
    {
        "id": "2650",
        "type": "disease",
        "text": "CLINICAL SIGNIFICANCE : This clinical case showing oral manifestations of meth mouth was presented to help dental practitioners recognize and manage patients who may be abusing methamphetamines .",
        "entities": [
            "meth mouth"
        ]
    },
    {
        "id": "2847",
        "type": "disease",
        "text": "A total of 167 courses at doses of 15 to 70 mg / m2 were evaluable .",
        "entities": []
    },
    {
        "id": "1204",
        "type": "disease",
        "text": "RESULTS : Sixty - seven of 926 patients ( 7 . 2 % ) required discontinuation of spironolactone due to hyperkalemia ( n = 33 ) or renal failure ( n = 34 ) .",
        "entities": [
            "hyperkalemia",
            "renal failure"
        ]
    },
    {
        "id": "4536",
        "type": "disease",
        "text": "After EE treatment , changes in immunostaining for 7H6 and ZO - 1 were similar to those seen in periportal hepatocytes after BDL , but distributed more diffusely throughout the lobule .",
        "entities": []
    },
    {
        "id": "2273",
        "type": "disease",
        "text": "This case report shows that ciprofloxacin may precipitate life - threatening thrombocytopenia and haemolytic anaemia , even in the early phases of treatment and without apparent previous exposures .",
        "entities": [
            "thrombocytopenia",
            "haemolytic anaemia"
        ]
    },
    {
        "id": "1400",
        "type": "disease",
        "text": "After 6 weeks of therapy , glomerular filtration rate was not different among the studied groups .",
        "entities": []
    },
    {
        "id": "2519",
        "type": "disease",
        "text": "Increasing doses of catecholamines , sedatives , and muscle relaxants administered through a central venous catheter were ineffective .",
        "entities": []
    },
    {
        "id": "1202",
        "type": "disease",
        "text": "Cases were patients who developed hyperkalemia ( K ( + ) > 5 . 0 mEq / L ) or renal insufficiency ( Cr > or = 2 . 5 mg / dL ) , and they were compared to 2 randomly selected controls per case .",
        "entities": [
            "hyperkalemia",
            "renal insufficiency"
        ]
    },
    {
        "id": "3299",
        "type": "disease",
        "text": "Three months later the patient was exposed to a single dose of metoprolol , diltiazem , propafenone ( since he had received this drug in the past ) , and sparteine ( as a probe for the debrisoquine / sparteine type polymorphism of oxidative drug metabolism ) .",
        "entities": []
    },
    {
        "id": "3668",
        "type": "disease",
        "text": "The median duration of survival in the 12 patients was 54 weeks ( range 21 to more than 156 weeks ) , with an 18 - month survival rate of 42 % .",
        "entities": []
    },
    {
        "id": "4119",
        "type": "disease",
        "text": "Habitual use of acetaminophen as a risk factor for chronic renal failure : a comparison with phenacetin .",
        "entities": [
            "chronic renal failure"
        ]
    },
    {
        "id": "3676",
        "type": "disease",
        "text": "The magnitude and time course of the increase in heart rate and the decrease in systolic blood pressure after nitroglycerin were similar in the normal and diabetic subjects without autonomic neuropathy , whereas a lesser increase in heart rate and a greater decrease in systolic blood pressure occurred in the diabetic subjects with autonomic neuropathy .",
        "entities": [
            "diabetic",
            "autonomic neuropathy",
            "diabetic",
            "autonomic neuropathy"
        ]
    },
    {
        "id": "908",
        "type": "disease",
        "text": "The morphine - induced hyperactivity was potentiated by scopolamine and attenuated by physostigmine .",
        "entities": [
            "hyperactivity"
        ]
    },
    {
        "id": "4555",
        "type": "disease",
        "text": "d - 1 given for 4 weeks , elevated blood pressure from 102 + / - 13 to 152 + / - 15 mm Hg and increased the synthesis of ET - 1 and the levels of ET - 1 mRNA in the mesenteric artery ( 240 % and 230 % , respectively ) .",
        "entities": []
    },
    {
        "id": "2397",
        "type": "disease",
        "text": "CONCLUSIONS : Reversible inferior colliculus lesions could be considered as the characteristic for metronidazole - induced encephalopathy , next to the dentate nucleus involvement .",
        "entities": [
            "inferior colliculus lesions",
            "encephalopathy"
        ]
    },
    {
        "id": "2653",
        "type": "disease",
        "text": "Antituberculosis therapy ( ATT ) - associated acute liver failure ( ATT - ALF ) is the commonest drug - induced ALF in South Asia .",
        "entities": [
            "acute liver failure",
            "ALF",
            "ALF"
        ]
    },
    {
        "id": "1332",
        "type": "disease",
        "text": "Variations of individuals were assessed by Wilcoxon ' s test .",
        "entities": []
    },
    {
        "id": "4052",
        "type": "disease",
        "text": "PURPOSE : To evaluate the response rate and toxic effects of vinorelbine ( VNB ) administered as a single agent in metastatic squamous cell esophageal carcinoma .",
        "entities": [
            "squamous cell esophageal carcinoma"
        ]
    },
    {
        "id": "3031",
        "type": "disease",
        "text": "These short - term studies showed that enalapril reduced arterial blood pressure ( 101 + / - 2 vs . 124 + / - 3 mm Hg , group 2 vs . 1 , P less than 0 . 05 ) and glomerular capillary pressure ( 54 + / - 1 vs . 61 + / - 2 mm Hg , P less than 0 . 05 ) without reducing albuminuria ( 617 + / - 50 vs . 570 + / - 47 mg / day ) or GFR ( 1 . 03 + / - 0 . 04 vs . 1 . 04 + / - 0 . 11 ml / min ) .",
        "entities": [
            "albuminuria"
        ]
    },
    {
        "id": "4215",
        "type": "disease",
        "text": "Therefore , in adult patients affected by HUS , dialysis should not be discontinued prematurely ; moreover , bilateral nephrectomy , for treatment of severe hypertension and microangiopathic hemolytic anemia , should be performed with caution .",
        "entities": [
            "HUS",
            "hypertension",
            "microangiopathic hemolytic anemia"
        ]
    },
    {
        "id": "2035",
        "type": "disease",
        "text": "Calcineurin - inhibitor therapy can lead to renal dysfunction in heart transplantation patients .",
        "entities": [
            "renal dysfunction"
        ]
    },
    {
        "id": "581",
        "type": "disease",
        "text": "Glomerular epithelial protein 1 ( GLEPP1 ) is a podocyte receptor membrane protein tyrosine phosphatase located on the apical cell membrane of visceral glomerular epithelial cell and foot processes .",
        "entities": []
    },
    {
        "id": "1095",
        "type": "disease",
        "text": "We suggest this mode of treatment for patients that were previously treated by drugs , acupuncture and biofeedback , with disappointing results .",
        "entities": []
    },
    {
        "id": "3396",
        "type": "disease",
        "text": "We have described a unique patient who had reversible and dose - related myasthenia gravis after penicillamine and chloroquine therapy for rheumatoid arthritis .",
        "entities": [
            "myasthenia gravis",
            "rheumatoid arthritis"
        ]
    },
    {
        "id": "2453",
        "type": "disease",
        "text": "In addition , working memory processing in ecstasy users has been shown to be associated with neural alterations in hippocampal and / or cortical regions as measured by functional magnetic resonance imaging ( fMRI ) .",
        "entities": []
    },
    {
        "id": "4485",
        "type": "disease",
        "text": "This is a case report of euphoria and choreoathetoid movements both transiently induced by rapid adjustment to the selective mu - opioid receptor agonist methadone in an inpatient previously abusing heroine and cocaine .",
        "entities": [
            "choreoathetoid movements"
        ]
    },
    {
        "id": "3780",
        "type": "disease",
        "text": "The effect of amiloride on lithium - induced polydipsia and polyuria and on the lithium concentration in the plasma , brain , kidney , thyroid and red blood cells was investigated in rats , chronically treated with LiCl .",
        "entities": [
            "polydipsia",
            "polyuria"
        ]
    },
    {
        "id": "2126",
        "type": "disease",
        "text": "Moreover , a positive correlation of histamine to gastric hemorrhage and to ulcer was found in those atherosclerotic rats .",
        "entities": [
            "gastric hemorrhage",
            "ulcer",
            "atherosclerotic"
        ]
    },
    {
        "id": "95",
        "type": "disease",
        "text": "To directly examine the importance of growth to Warfarin - induced artery calcification in animals of the same age , 20 - day - old rats were fed for 2 weeks either an ad libitum diet or a 6 - g / d restricted diet that maintains weight but prevents growth .",
        "entities": [
            "artery calcification"
        ]
    },
    {
        "id": "2440",
        "type": "disease",
        "text": "There was no significant difference in the frequency of signs or symptoms between the two groups although neurotoxicity symptoms presented mostly with lower scores of severity in group G .",
        "entities": [
            "neurotoxicity"
        ]
    },
    {
        "id": "1816",
        "type": "disease",
        "text": "Lipopolysaccharide pretreatment did not affect the basal body temperature or methamphetamine - elicited hyperthermia three days later .",
        "entities": [
            "hyperthermia"
        ]
    },
    {
        "id": "1809",
        "type": "disease",
        "text": "We also examined the neuroprotective effects of maltolyl p - coumarate in vitro using SH - SY5Y cells .",
        "entities": []
    },
    {
        "id": "502",
        "type": "disease",
        "text": "CONCLUSIONS : The combination of cisplatin and amifostine in this study resulted in an overall response rate of 16 % .",
        "entities": []
    },
    {
        "id": "1456",
        "type": "disease",
        "text": "Initial cardiopulmonary resuscitation and immediate treatment with adrenaline ( epinephrine ) , atropine and furosemide was successful .",
        "entities": []
    },
    {
        "id": "1692",
        "type": "disease",
        "text": "Influence of smoking on developing cochlea .",
        "entities": []
    },
    {
        "id": "483",
        "type": "disease",
        "text": "Results show that cumulative HAART caused mitochondrial CM with elevated LA in AIDS transgenic mice .",
        "entities": [
            "CM",
            "AIDS"
        ]
    },
    {
        "id": "363",
        "type": "disease",
        "text": "Since AAP , AMI and DOX undergo biotransformation and are known to produce damaging radicals in vivo , the protection by GSPE may be linked to both inhibition of metabolism and / or detoxification of cytotoxic radicals .",
        "entities": []
    },
    {
        "id": "4275",
        "type": "disease",
        "text": "Atypical sensations following the use of subcutaneous sumatriptan are common , but of uncertain origin .",
        "entities": [
            "Atypical sensations"
        ]
    },
    {
        "id": "771",
        "type": "disease",
        "text": "The results indicated that concomitant treatment with gum Arabic and GM significantly increased creatinine and urea by about 183 and 239 % , respectively ( compared to 432 and 346 % , respectively , in rats treated with cellulose and GM ) , and decreased that of cortical GSH by 21 % ( compared to 27 % in the cellulose plus GM group ) The GM - induced proximal tubular necrosis appeared to be slightly less severe in rats given GM together with gum Arabic than in those given GM and cellulose .",
        "entities": [
            "tubular necrosis"
        ]
    },
    {
        "id": "527",
        "type": "disease",
        "text": "CONCLUSIONS : Patients who are more than 10 years post - OLTX have CRF and ESRD at a high rate .",
        "entities": [
            "CRF",
            "ESRD"
        ]
    },
    {
        "id": "2113",
        "type": "disease",
        "text": "Based on the finding that VPU and VPA could protect the animals against pilocarpine - induced seizure it is suggested that the reduction of inhibitory amino acid neurotransmitters was comparatively minor and offset by a pronounced reduction of glutamate and aspartate .",
        "entities": [
            "seizure"
        ]
    },
    {
        "id": "475",
        "type": "disease",
        "text": "Myocardial histologic features were analyzed semiquantitatively and results were confirmed by transmission electron microscopy .",
        "entities": []
    },
    {
        "id": "2704",
        "type": "disease",
        "text": "Salvage therapy with nelarabine , etoposide , and cyclophosphamide in relapsed / refractory paediatric T - cell lymphoblastic leukaemia and lymphoma .",
        "entities": [
            "T - cell lymphoblastic leukaemia and lymphoma"
        ]
    },
    {
        "id": "3950",
        "type": "disease",
        "text": "None of the sera with negative RAST for AX were positive to BPO .",
        "entities": []
    },
    {
        "id": "1594",
        "type": "disease",
        "text": "The mechanisms of sirolimus - associated proteinuria are multifactorial and may be due to an increase in glomerular capillary pressure following calcineurin inhibitor withdrawal .",
        "entities": [
            "proteinuria"
        ]
    },
    {
        "id": "2112",
        "type": "disease",
        "text": "In addition , a statistically significant reduction was also observed on the level of GABA and glycine but less than a drastic reduction of glutamate and aspartate level .",
        "entities": []
    },
    {
        "id": "1777",
        "type": "disease",
        "text": "In other individuals with no underlying atherosclerotic obstruction , coronary occlusion may be due to spasm , thrombus , or both .",
        "entities": [
            "atherosclerotic obstruction",
            "coronary occlusion",
            "spasm",
            "thrombus"
        ]
    },
    {
        "id": "1005",
        "type": "disease",
        "text": "The development of psychosis related to antiepileptic drug treatment is usually attributed to the interaction between the epileptic brain substratum and the antiepileptic drugs .",
        "entities": [
            "psychosis",
            "epileptic"
        ]
    },
    {
        "id": "3206",
        "type": "disease",
        "text": "Verapamil is an effective and relatively - safe antihypertensive drug .",
        "entities": []
    },
    {
        "id": "884",
        "type": "disease",
        "text": "Associated factors were co - treatment with other centrally antimuscarinic agents , poor clinical outcome , older age , and longer hospitalization ( by 17 . 5 days , increasing cost ) ; sex , diagnosis or medical co - morbidity , and daily clozapine dose , which fell with age , were unrelated .",
        "entities": []
    },
    {
        "id": "967",
        "type": "disease",
        "text": "Monkeys with acute ( short - term ) MPTP exposure , rapid symptom onset and short symptom duration prior to initiation of levodopa therapy developed dyskinesia between 11 and 24 days of daily levodopa administration .",
        "entities": [
            "dyskinesia"
        ]
    },
    {
        "id": "3687",
        "type": "disease",
        "text": "Total cell yields from DES - treated pituitaries increased from 1 . 3 times control yields at 8 days of treatment to 58 . 9 times control values by day 150 .",
        "entities": []
    },
    {
        "id": "456",
        "type": "disease",
        "text": "STUDY OBJECTIVE : We sought to compare the rate of akathisia after administration of intravenous prochlorperazine as a 2 - minute bolus or 15 - minute infusion .",
        "entities": [
            "akathisia"
        ]
    },
    {
        "id": "2657",
        "type": "disease",
        "text": "Another 15 ( 1 . 2 % ) had ATT and simultaneous hepatitis virus infection .",
        "entities": [
            "hepatitis virus infection"
        ]
    },
    {
        "id": "4142",
        "type": "disease",
        "text": "Diabetic rats progressively developed albuminuria reaching 40 . 3 ( 32 . 2 - 62 . 0 ) mg / 24 h after 8 months in contrast to the control animals ( 0 . 8 ( 0 . 2 - 0 . 9 ) mg / 24 h , p < 0 . 002 ) .",
        "entities": [
            "Diabetic",
            "albuminuria"
        ]
    },
    {
        "id": "206",
        "type": "disease",
        "text": "RESULTS : Two hundred sixty - five patients were included in this analysis ( n = 92 , 93 , and 80 for placebo , low dose , and high dose , respectively ) .",
        "entities": []
    },
    {
        "id": "1902",
        "type": "disease",
        "text": "Injections areas were assessed for the presence of bruising at 48 and 72 hours after each injection .",
        "entities": [
            "bruising"
        ]
    },
    {
        "id": "3725",
        "type": "disease",
        "text": "In two patients , the arrhythmia degenerated into irreversible ventricular fibrillation and both patients died .",
        "entities": [
            "arrhythmia",
            "ventricular fibrillation"
        ]
    },
    {
        "id": "3216",
        "type": "disease",
        "text": "Obviously , there is a need for effective chemotherapy .",
        "entities": []
    },
    {
        "id": "1232",
        "type": "disease",
        "text": "The patient was successfully treated with a graft stent .",
        "entities": []
    },
    {
        "id": "2208",
        "type": "disease",
        "text": "We report that prenatally protein deprived ( PD ) female rats showed an increased stereotypic response to apomorphine and an increased locomotor response to amphetamine in adulthood .",
        "entities": []
    },
    {
        "id": "1138",
        "type": "disease",
        "text": "In another series of measurements , reproducibility and reference values of the tremor was assessed in 65 healthy subjects in three sessions , at 9 a . m . , 4 p . m . and 9 a . m . , respectively , 1 week later .",
        "entities": [
            "tremor"
        ]
    },
    {
        "id": "2123",
        "type": "disease",
        "text": "Gastric acid back - diffusion , mucosal LPO generation , histamine concentration , microvascular permeability , luminal hemoglobin content and ulcer areas were determined .",
        "entities": [
            "ulcer"
        ]
    },
    {
        "id": "619",
        "type": "disease",
        "text": "Bovine liver erythroid cells were cultured on monolayers of human bone marrow endothelial cells previously treated with EPO and IGF - IL - 3 .",
        "entities": []
    },
    {
        "id": "1800",
        "type": "disease",
        "text": "SCr increases > or = 0 . 5 mg / dL occurred in 4 . 4 % ( 9 of 204 patients ) after iopamidol and 6 . 7 % ( 14 of 210 patients ) after iodixanol ( P = 0 . 39 ) , whereas rates of SCr increases > or = 25 % were 9 . 8 % and 12 . 4 % , respectively ( P = 0 . 44 ) .",
        "entities": []
    },
    {
        "id": "4378",
        "type": "disease",
        "text": "Plasma sodium concentrations were found to be slightly increased in the Li - treated rats compared with those in controls .",
        "entities": []
    },
    {
        "id": "3841",
        "type": "disease",
        "text": "RESULTS : Mean alprazolam dose was 5 mg daily .",
        "entities": []
    },
    {
        "id": "903",
        "type": "disease",
        "text": "Allopregnanolone and pregnanolone , but not ganaxolone , also reduced cumulative lethality associated with kindling .",
        "entities": []
    },
    {
        "id": "3785",
        "type": "disease",
        "text": "In all the experiments , the attenuation of the lithium - induced diabetes - insipidus - like syndrome by amiloride was accompanied by a reduction of the ratio between the lithium concentration in the renal medulla and its levels in the blood and an elevation in the plasma potassium level .",
        "entities": [
            "diabetes - insipidus - like syndrome"
        ]
    },
    {
        "id": "62",
        "type": "disease",
        "text": "METHODS : Forty - nine patients with advanced NSCLC were included , 38 of whom were age > / = 70 years and 11 were age < 70 years but who had some contraindication to receiving cisplatin .",
        "entities": [
            "NSCLC"
        ]
    },
    {
        "id": "4521",
        "type": "disease",
        "text": "RESULTS : The main pathologic diagnoses ( some overlap ) were acute rejection ( AR ; n = 4 ) , chronic rejection ( CR ; n = 5 ) , AR + CR ( n = 4 ) , recurrent IgA nephropathy ( n = 5 ) , normal findings ( n = 2 ) , minimal - type chronic FK506 nephropathy ( n = 9 ) , and mild - type FK506 nephropathy ( n = 11 ) .",
        "entities": [
            "IgA nephropathy",
            "nephropathy",
            "nephropathy"
        ]
    },
    {
        "id": "2625",
        "type": "disease",
        "text": "The mean doses of MZ and FL were 4 . 3 + / - 1 . 9 mg and 0 . 28 + / - 0 . 2 mg , respectively .",
        "entities": []
    },
    {
        "id": "3594",
        "type": "disease",
        "text": "It is recommended that either glycopyrrolate 10 micrograms kg - 1 or atropine 20 micrograms kg - 1 i . v . should immediately precede induction of anaesthesia , in children , if the repeated administration of suxamethonium is anticipated .",
        "entities": []
    },
    {
        "id": "830",
        "type": "disease",
        "text": "Eight healthy men were recruited .",
        "entities": []
    },
    {
        "id": "1520",
        "type": "disease",
        "text": "The following case is a report of cauda equina syndrome possibly caused by epidural injection of triamcinolone and bupivacaine .",
        "entities": [
            "cauda equina syndrome"
        ]
    },
    {
        "id": "1213",
        "type": "disease",
        "text": "Haloperidol administration ( one dose of 12 mg / kg once a week s . c . ) for 4 weeks caused an increase in vacuous chewing , tongue protrusion and duration of facial twitching observed in four weekly evaluations .",
        "entities": []
    },
    {
        "id": "3891",
        "type": "disease",
        "text": "The patient was treated with methylprednisolone and gradually improved .",
        "entities": []
    },
    {
        "id": "2295",
        "type": "disease",
        "text": "Repetitive transcranial magnetic stimulation for levodopa - induced dyskinesias in Parkinson ' s disease .",
        "entities": [
            "dyskinesias",
            "Parkinson ' s disease"
        ]
    },
    {
        "id": "2306",
        "type": "disease",
        "text": "Priapism is the prolonged erection of the penis in the absence of sexual arousal .",
        "entities": [
            "Priapism"
        ]
    },
    {
        "id": "1301",
        "type": "disease",
        "text": "GNC92H2 was delivered 30 min before , concomitantly or 3 min after cocaine treatment .",
        "entities": []
    },
    {
        "id": "4109",
        "type": "disease",
        "text": "Two pathologic complete responses were observed in patients who had achieved clinical complete responses .",
        "entities": []
    },
    {
        "id": "4443",
        "type": "disease",
        "text": "It may be concluded that , like other tricyclic antidepressants studied previously , TRI given repeatedly increases the responsiveness of brain dopamine D2 and D3 ( locomotor activity but not stereotypy ) as well as alpha1 - adrenergic receptors to their agonists .",
        "entities": []
    },
    {
        "id": "2166",
        "type": "disease",
        "text": "Course following treatment modifications .",
        "entities": []
    },
    {
        "id": "3402",
        "type": "disease",
        "text": "The other rats showed a strong decrease in the rigidity and the occurrence of stereotyped ( S ) licking and / or gnawing in presence of akinetic or hyperkinetic ( K ) behaviour ( AS / KS group ) , suggesting signs of dopaminergic activation .",
        "entities": [
            "rigidity",
            "akinetic",
            "hyperkinetic"
        ]
    },
    {
        "id": "2521",
        "type": "disease",
        "text": "Thus , interference with the central venous infusion by the dialysis catheter was suspected .",
        "entities": []
    },
    {
        "id": "2082",
        "type": "disease",
        "text": "Acute bronchodilating effects of ipratropium bromide and theophylline in chronic obstructive pulmonary disease .",
        "entities": [
            "chronic obstructive pulmonary disease"
        ]
    },
    {
        "id": "365",
        "type": "disease",
        "text": "Additionally , this may have been the first report on AMI - induced apoptotic death in the lung tissue .",
        "entities": []
    },
    {
        "id": "3288",
        "type": "disease",
        "text": "Although the AE RBCs from an individual not taking dapsone had increased incubated Heinz body formation , the GSH content and GSH stability were normal .",
        "entities": []
    },
    {
        "id": "1687",
        "type": "disease",
        "text": "Echocardiographic Doppler studies were performed before infusion and after 15 min of infusion at each rate .",
        "entities": []
    },
    {
        "id": "2223",
        "type": "disease",
        "text": "FINDINGS : A temporal relationship was found between topical papaverine and BAEP changes leading to complete waveform loss .",
        "entities": []
    },
    {
        "id": "389",
        "type": "disease",
        "text": "We suggest that repeated endothelial injury , including immunologic injury , may be the cause of this lesion both in allografts and native kidneys .",
        "entities": [
            "endothelial injury",
            "immunologic injury"
        ]
    },
    {
        "id": "1532",
        "type": "disease",
        "text": "She had a gradual return of motor function and ability of feeling Foley catheter .",
        "entities": []
    },
    {
        "id": "191",
        "type": "disease",
        "text": "METHODS : A review of admissions during a 6 - year period revealed 14 patients with cocaine - related aneurysms .",
        "entities": [
            "aneurysms"
        ]
    },
    {
        "id": "2834",
        "type": "disease",
        "text": "Neuromuscular monitoring was used in two patients .",
        "entities": []
    },
    {
        "id": "3523",
        "type": "disease",
        "text": "Thrombotic microangiopathy and renal failure associated with antineoplastic chemotherapy .",
        "entities": [
            "Thrombotic microangiopathy",
            "renal failure"
        ]
    },
    {
        "id": "2679",
        "type": "disease",
        "text": "Central nervous system ( CNS ) complications during treatment of childhood acute lymphoblastic leukemia ( ALL ) remain a challenging clinical problem .",
        "entities": [
            "Central nervous system ( CNS ) complications",
            "acute lymphoblastic leukemia",
            "ALL"
        ]
    },
    {
        "id": "3597",
        "type": "disease",
        "text": "There was a fulminant clinical course from start of symptoms until death .",
        "entities": [
            "death"
        ]
    },
    {
        "id": "3591",
        "type": "disease",
        "text": "A control group was included for comparison with the lower dose range of glycopyrrolate and atropine .",
        "entities": []
    },
    {
        "id": "3954",
        "type": "disease",
        "text": "Diagnosis of these patients can be achieved only if specific AX - related reagents are employed .",
        "entities": []
    },
    {
        "id": "2633",
        "type": "disease",
        "text": "Effect of direct intracoronary administration of methylergonovine in patients with and without variant angina .",
        "entities": [
            "variant angina"
        ]
    },
    {
        "id": "3960",
        "type": "disease",
        "text": "Left ventricular filling pressure decreased from 19 + / - 2 to 11 + / - 2 mm Hg ( P less than 0 . 001 ) .",
        "entities": []
    },
    {
        "id": "3735",
        "type": "disease",
        "text": "The stone passed spontaneously and was found to contain a triamterene metabolite admixed with uric acid salts .",
        "entities": []
    },
    {
        "id": "1938",
        "type": "disease",
        "text": "Acute vocal fold palsy after acute disulfiram intoxication .",
        "entities": [
            "vocal fold palsy"
        ]
    },
    {
        "id": "965",
        "type": "disease",
        "text": "Due to the interdependence of risk factors in clinical populations , it is difficult to independently examine factors that may influence the development of LIDs .",
        "entities": [
            "LIDs"
        ]
    },
    {
        "id": "2478",
        "type": "disease",
        "text": "Comparative cognitive and subjective side effects of immediate - release oxycodone in healthy middle - aged and older adults .",
        "entities": []
    },
    {
        "id": "3835",
        "type": "disease",
        "text": "Controlled study in agoraphobia with panic disorder .",
        "entities": [
            "agoraphobia",
            "panic disorder"
        ]
    },
    {
        "id": "1582",
        "type": "disease",
        "text": "The events are consistent with a severe reaction to calcium chelation by sodium citrate anticoagulant resulting in symptomatic systemic hypocalcemia .",
        "entities": [
            "hypocalcemia"
        ]
    },
    {
        "id": "3755",
        "type": "disease",
        "text": "Clinical nephrotoxicity of tobramycin and gentamicin .",
        "entities": [
            "nephrotoxicity"
        ]
    },
    {
        "id": "3859",
        "type": "disease",
        "text": "It is necessary that both oncologists and neurologists be fully aware of this unusual complication .",
        "entities": []
    },
    {
        "id": "473",
        "type": "disease",
        "text": "To determine mitochondrial events from HAART in vivo , 8 - week - old hemizygous transgenic AIDS mice ( NL4 - 3Delta gag / pol ; TG ) and wild - type FVB / n littermates were treated with the HAART combination of zidovudine , lamivudine , and indinavir or vehicle control for 10 days or 35 days .",
        "entities": [
            "AIDS"
        ]
    },
    {
        "id": "2841",
        "type": "disease",
        "text": "In a few cases the presence of active denervation signified a poor prognosis , with only slight improvement .",
        "entities": []
    },
    {
        "id": "4015",
        "type": "disease",
        "text": "Thirteen patients developed a raised serum amylase without abdominal pain .",
        "entities": [
            "abdominal pain"
        ]
    },
    {
        "id": "1665",
        "type": "disease",
        "text": "Thus , in cystitis substantial changes of the efferent functional responses occur .",
        "entities": [
            "cystitis"
        ]
    },
    {
        "id": "2865",
        "type": "disease",
        "text": "Desferrioxamine withdrawal resulted in a complete recovery of visual function in 1 patient and partial recovery in 3 , and a complete reversal of hearing loss in 3 patients and partial recovery in 3 .",
        "entities": [
            "hearing loss"
        ]
    },
    {
        "id": "4392",
        "type": "disease",
        "text": "The aim of this study was to describe this hearing loss and to investigate other factors influencing the degree of hearing loss .",
        "entities": [
            "hearing loss",
            "hearing loss"
        ]
    },
    {
        "id": "348",
        "type": "disease",
        "text": "Two patients developed acute tubular necrosis , characterized clinically by acute oliguric renal failure , while they were receiving a combination of cephalothin sodium and gentamicin sulfate therapy .",
        "entities": [
            "acute tubular necrosis",
            "oliguric renal failure"
        ]
    },
    {
        "id": "2189",
        "type": "disease",
        "text": "Furthermore , adriamycin induced the formation of autophagic vacuoles , and 3MA strongly downregulated the expression of beclin 1 in adriamycin - induced failing heart and inhibited the formation of autophagic vacuoles .",
        "entities": []
    },
    {
        "id": "2582",
        "type": "disease",
        "text": "OBJECTIVE : To determine the safety and efficacy of adjunctive bupropion sustained - release ( SR ) on male sexual dysfunction ( SD ) induced by a selective serotonin reuptake inhibitor ( SSRI ) , as SD is a common side - effect of SSRIs and the most effective treatments have yet to be determined .",
        "entities": [
            "sexual dysfunction",
            "SD",
            "SD"
        ]
    },
    {
        "id": "3260",
        "type": "disease",
        "text": "Preoperative assessment should focus on cardiovascular status and serum potassium level .",
        "entities": []
    },
    {
        "id": "1993",
        "type": "disease",
        "text": "Advances in the field of transplantation provide a better quality of life and allow more favorable conditions for growth and development in children .",
        "entities": []
    },
    {
        "id": "2078",
        "type": "disease",
        "text": "RESULT ( S ) : A 36 - year - old Chinese woman developed central retinal vein occlusion after eight courses of CC .",
        "entities": [
            "retinal vein occlusion"
        ]
    },
    {
        "id": "3646",
        "type": "disease",
        "text": "In experimental animals excess deposition of collagen and glycoaminoglycans was observed in the subendothelial and medial layer of the aortic wall , together with prominent basal membrane substance around aortic smooth muscle cells .",
        "entities": []
    },
    {
        "id": "278",
        "type": "disease",
        "text": "Although urinary incontinence is listed as one side effect of these drugs in their package inserts there is only one report in the literature .",
        "entities": [
            "urinary incontinence"
        ]
    },
    {
        "id": "868",
        "type": "disease",
        "text": "Hb , PSA and Testosterone measurements were recorded .",
        "entities": []
    },
    {
        "id": "3421",
        "type": "disease",
        "text": "Recurrent reversible acute renal failure from amphotericin .",
        "entities": [
            "acute renal failure"
        ]
    },
    {
        "id": "4010",
        "type": "disease",
        "text": "A positive weight response was seen in 16 % of patients .",
        "entities": []
    },
    {
        "id": "1423",
        "type": "disease",
        "text": "Compared with MDMA - free polydrug controls , MDMA polydrug users showed impairments in set shifting and memory updating , and also in social and emotional judgement processes .",
        "entities": []
    },
    {
        "id": "3538",
        "type": "disease",
        "text": "Previously recognized side effects , particularly tremor and gastrointestinal problems , were more frequent in the mexiletine group than in the placebo group .",
        "entities": [
            "tremor",
            "gastrointestinal problems"
        ]
    },
    {
        "id": "919",
        "type": "disease",
        "text": "When comparing all lithium treated versus non - lithium - treated groups , lithium caused a reduction in glomerular filtration rate ( GFR ) without significant changes in effective renal plasma flow ( as determined by a marker secreted into the proximal tubules ) or lithium clearance .",
        "entities": []
    },
    {
        "id": "3519",
        "type": "disease",
        "text": "In the twin pregnancy , the mother had Crohn ' s disease .",
        "entities": [
            "Crohn ' s disease"
        ]
    },
    {
        "id": "3327",
        "type": "disease",
        "text": "Based on these data , a plan of management was developed that allows effective yet safe administration of deferoxamine .",
        "entities": []
    },
    {
        "id": "395",
        "type": "disease",
        "text": "Therefore , three novel sigma receptor ligands with antagonist activity were evaluated in Swiss Webster mice : BD1018 ( 3S - 1 - [ 2 - ( 3 , 4 - dichlorophenyl ) ethyl ] - 1 , 4 - diazabicyclo [ 4 . 3 . 0 ] nonane ) , BD1063 ( 1 - [ 2 - ( 3 , 4 - dichlorophenyl ) ethyl ] - 4 - methylpiperazine ) , and LR132 ( 1R , 2S - ( + ) - cis - N - [ 2 - ( 3 , 4 - dichlorophenyl ) ethyl ] - 2 - ( 1 - pyrrolidinyl ) cyclohexylamine ) .",
        "entities": []
    },
    {
        "id": "3576",
        "type": "disease",
        "text": "Dothiepin and amitriptyline were equally effective in alleviating the symptoms of depressive illness , and both were significantly superior to placebo .",
        "entities": [
            "depressive illness"
        ]
    },
    {
        "id": "3495",
        "type": "disease",
        "text": "Azathioprine treatment benefited 19 ( 66 % ) out of 29 patients suffering from severe psoriasis .",
        "entities": [
            "psoriasis"
        ]
    },
    {
        "id": "1544",
        "type": "disease",
        "text": "No association was found for hormone use less than 1 year .",
        "entities": []
    },
    {
        "id": "1720",
        "type": "disease",
        "text": "Our findings indicate that beta2 - adrenoceptor overstimulation during an early critical period results in microglial activation associated with innate neuroinflammatory pathways and behavioral abnormalities , similar to those described in autism .",
        "entities": [
            "behavioral abnormalities",
            "autism"
        ]
    },
    {
        "id": "3243",
        "type": "disease",
        "text": "Five cm H2O CPAP during nitroprusside did not further alter any of the above - mentioned variables .",
        "entities": []
    },
    {
        "id": "2581",
        "type": "disease",
        "text": "The effects of the adjunctive bupropion on male sexual dysfunction induced by a selective serotonin reuptake inhibitor : a double - blind placebo - controlled and randomized study .",
        "entities": [
            "sexual dysfunction"
        ]
    },
    {
        "id": "2624",
        "type": "disease",
        "text": "RESULTS : All patients ( 65 + / - 16 yrs ; 58 % males ) finished the examination .",
        "entities": []
    },
    {
        "id": "676",
        "type": "disease",
        "text": "Severe ocular and orbital toxicity after intracarotid injection of carboplatin for recurrent glioblastomas .",
        "entities": [
            "ocular and orbital toxicity",
            "glioblastomas"
        ]
    },
    {
        "id": "638",
        "type": "disease",
        "text": "The pathophysiology of painful temporomandibular disorders is not fully understood , but evidence suggests that muscle pain modulates motor function in characteristic ways .",
        "entities": [
            "temporomandibular disorders",
            "muscle pain"
        ]
    },
    {
        "id": "1270",
        "type": "disease",
        "text": "However , when the patient was questioned about use of herbal products and supplements , the use of creatine monohydrate was revealed .",
        "entities": []
    },
    {
        "id": "2205",
        "type": "disease",
        "text": "Prenatal protein deprivation alters dopamine - mediated behaviors and dopaminergic and glutamatergic receptor binding .",
        "entities": []
    },
    {
        "id": "430",
        "type": "disease",
        "text": "These data indicate that the free ED50 in plasma for terfenadine ( 1 . 9 nM ) , terodiline ( 76 nM ) , cisapride ( 11 nM ) and E4031 ( 1 . 9 nM ) closely correlate with the free concentration in man causing QT effects .",
        "entities": []
    },
    {
        "id": "3739",
        "type": "disease",
        "text": "Spontaneous resolution occurred following cessation of the drug .",
        "entities": []
    },
    {
        "id": "553",
        "type": "disease",
        "text": "It was found that the transformation of exencephalic tissue was not simply size - dependent , and all cases of anencephaly at E18 . 5 resulted from embryos with a large amount of exencephalic tissue at E13 . 5 .",
        "entities": [
            "exencephalic",
            "anencephaly",
            "exencephalic"
        ]
    },
    {
        "id": "530",
        "type": "disease",
        "text": "However , an increase of serum creatinine at various times postoperatively is more predictive of the development of CRF or ESRD .",
        "entities": [
            "CRF",
            "ESRD"
        ]
    },
    {
        "id": "2010",
        "type": "disease",
        "text": "The Receiver Operative Characteristic Curve showed that OD > 1 . 27 in the isolated - HIT group had a significantly higher chance of developing thrombosis by day 30 .",
        "entities": [
            "HIT",
            "thrombosis"
        ]
    },
    {
        "id": "1459",
        "type": "disease",
        "text": "High doses of atropine ( up to 50 mg per 24 hours ) , adrenaline and dopamine were necessary .",
        "entities": []
    },
    {
        "id": "2711",
        "type": "disease",
        "text": "Thermal enhancement of Adriamycin - mediated antitumor activity and normal tissue toxicities by whole body hyperthermia were compared using a F344 rat model .",
        "entities": [
            "toxicities",
            "hyperthermia"
        ]
    },
    {
        "id": "2360",
        "type": "disease",
        "text": "The data further suggest that the consolidation of this memory is an important interim stage , and may take up to one day .",
        "entities": []
    },
    {
        "id": "3411",
        "type": "disease",
        "text": "Rhabdomyolysis is a potentially lethal syndrome that psychiatric patients seem predisposed to develop .",
        "entities": [
            "Rhabdomyolysis",
            "psychiatric"
        ]
    },
    {
        "id": "4445",
        "type": "disease",
        "text": "Pethidine - associated seizure in a healthy adolescent receiving pethidine for postoperative pain control .",
        "entities": [
            "seizure",
            "postoperative pain"
        ]
    },
    {
        "id": "2960",
        "type": "disease",
        "text": "Groups of 5 - week old male Fischer - 344 rats were fed for 7 - 25 months semipurified choline - devoid or choline - supplemented diets , containing or not 0 . 06 % phenobarbital .",
        "entities": []
    },
    {
        "id": "128",
        "type": "disease",
        "text": "Hemolysis caused by TAM was not preceded by the leakage of K ( + ) from the cells , also excluding a colloid - osmotic type mechanism of hemolysis , according to the effects on osmotic fragility curves .",
        "entities": [
            "Hemolysis",
            "hemolysis"
        ]
    },
    {
        "id": "2674",
        "type": "disease",
        "text": "Subjects were 1210 inpatients with New York Heart Association ( NYHA ) functional class II and III .",
        "entities": []
    },
    {
        "id": "3249",
        "type": "disease",
        "text": "Mean arterial pressure was decreased to 50 mm Hg for 30 minutes either by hemorrhage ( HEM , n = 7 ) or by continuous infusion of sodium nitroprusside ( SNP , n = 7 ) .",
        "entities": [
            "hemorrhage",
            "HEM"
        ]
    },
    {
        "id": "2350",
        "type": "disease",
        "text": "Systematic investigations of the human capacity to remember sensory features of experimental pain are sparse .",
        "entities": [
            "pain"
        ]
    },
    {
        "id": "1663",
        "type": "disease",
        "text": "In contrast to controls , methoctramine increased - - instead of decreased - - the tonic responses at high frequencies .",
        "entities": []
    },
    {
        "id": "12",
        "type": "disease",
        "text": "Further studies on effects of irrigation solutions on rat bladders .",
        "entities": []
    },
    {
        "id": "1887",
        "type": "disease",
        "text": "Admission laboratory tests were as follows : alanine aminotransferase , 67 U / L ( reference range , 10 - 37 U / L ) ; aspartate aminotransferase , 98 U / L ( 10 - 40 U / L ) ; alkaline phosphatase , 513 U / L ( 0 - 270 U / L ) ; gamma - glutamyltransferase , 32 U / L ( 7 - 49 U / L ) ; amylase , 46 U / L ( 0 - 220 U / L ) ; total bilirubin , 20 . 1 mg / dL ( 0 . 2 - 1 . 0 mg / dL ) ; direct bilirubin , 14 . 8 mg / dL ( 0 - 0 . 3 mg / dL ) ; and albumin , 4 . 7 mg / dL ( 3 . 5 - 5 . 4 mg / dL ) .",
        "entities": []
    },
    {
        "id": "3829",
        "type": "disease",
        "text": "No significant differences between groups were found at enrollment .",
        "entities": []
    },
    {
        "id": "3305",
        "type": "disease",
        "text": "The open study lasted for four weeks ; the drug was administrated in the form of 1 mg tablets .",
        "entities": []
    },
    {
        "id": "4347",
        "type": "disease",
        "text": "For previously treated advanced breast cancer , there is no standard second - line therapy .",
        "entities": [
            "breast cancer"
        ]
    },
    {
        "id": "4158",
        "type": "disease",
        "text": "In both cases , discontinuation of FK506 and treatment with plasma exchange , fresh frozen plasma replacement , corticosteroids , aspirin , and dipyridamole led to resolution of MAHA .",
        "entities": [
            "MAHA"
        ]
    },
    {
        "id": "3124",
        "type": "disease",
        "text": "Physicians who use sulfasalazine to treat patients with inflammatory bowel disease should be aware of the signs of sulfasalazine - induced lupus syndrome .",
        "entities": [
            "inflammatory bowel disease",
            "lupus syndrome"
        ]
    },
    {
        "id": "298",
        "type": "disease",
        "text": "The possible interaction of tizanidine and other antihypertensive agents should be kept in mind when prescribing therapy to treat either hypertension or spasticity in such patients .",
        "entities": [
            "hypertension",
            "spasticity"
        ]
    },
    {
        "id": "1588",
        "type": "disease",
        "text": "Sirolimus is a novel immunosuppressant with potent antiproliferative actions through its ability to inhibit the raptor - containing mammalian target of rapamycin protein kinase .",
        "entities": []
    },
    {
        "id": "712",
        "type": "disease",
        "text": "Offspring of rats administered dexamethasone on days 15 and 16 gestation had a 20 % reduction in glomerular number compared with control at 6 to 9 months of age ( 22 527 + / - 509 versus 28 050 + / - 561 , P < 0 . 05 ) , which was comparable to the percent reduction in glomeruli measured at 3 weeks of age .",
        "entities": [
            "reduction in glomerular number"
        ]
    },
    {
        "id": "1091",
        "type": "disease",
        "text": "Idiopathic subjective tinnitus ( IST ) is one of the most obscure otological pathologies .",
        "entities": [
            "Idiopathic subjective tinnitus",
            "IST"
        ]
    },
    {
        "id": "2017",
        "type": "disease",
        "text": "Its activity is believed to be due modulation of the tumour milieu , including downregulation of angiogenesis and inflammatory cytokines .",
        "entities": [
            "tumour"
        ]
    },
    {
        "id": "3709",
        "type": "disease",
        "text": "In both instances , suspicion of the presence of carcinoma was aroused by the palpation of a small nodule in the vaginal fornix .",
        "entities": [
            "carcinoma"
        ]
    },
    {
        "id": "3992",
        "type": "disease",
        "text": "Under anesthesia , the superior temporal gyrus of adult macaque monkeys was exposed , and the tonotopic organization of A1 was mapped using conventional microelectrode recording techniques .",
        "entities": []
    },
    {
        "id": "257",
        "type": "disease",
        "text": "Ketamine can improve morphine analgesia in difficult pain syndromes , such as neuropathic pain .",
        "entities": [
            "pain",
            "neuropathic pain"
        ]
    },
    {
        "id": "4097",
        "type": "disease",
        "text": "We initiated a phase I / II trial to determine the response and toxicity of escalating paclitaxel doses combined with fixed - dose cisplatin with granulocyte colony - stimulating factor support in patients with untreated locally advanced inoperable head and neck carcinoma .",
        "entities": [
            "toxicity",
            "head and neck carcinoma"
        ]
    },
    {
        "id": "3724",
        "type": "disease",
        "text": "In four patients , the arrhythmia was rapidly diagnosed and treated with disappearance of further episodes of the arrhythmia .",
        "entities": [
            "arrhythmia",
            "arrhythmia"
        ]
    },
    {
        "id": "2201",
        "type": "disease",
        "text": "Side effects occurred after both therapeutic and prophylactic intake and were graded from moderate to severe .",
        "entities": []
    },
    {
        "id": "2569",
        "type": "disease",
        "text": "However , a 14 % ( from 70 + / - 8 % to 60 + / - 7 % ) reduction in S ( c ) O ( 2 ) ( P < 0 . 05 ) followed with no change in CO ( 3 . 7 + / - 1 . 1 to 3 . 4 + / - 0 . 9 l min ( - 1 ) ) .",
        "entities": []
    },
    {
        "id": "730",
        "type": "disease",
        "text": "The FK506 plus SRL combination showed only a marginally higher degree of fibrosis as compared with controls ( P = 0 . 05 ) .",
        "entities": [
            "fibrosis"
        ]
    },
    {
        "id": "188",
        "type": "disease",
        "text": "Intracranial aneurysms and cocaine abuse : analysis of prognostic indicators .",
        "entities": [
            "Intracranial aneurysms",
            "cocaine abuse"
        ]
    },
    {
        "id": "1464",
        "type": "disease",
        "text": "On the next day he died , probably as a result of heart failure .",
        "entities": [
            "heart failure"
        ]
    },
    {
        "id": "2996",
        "type": "disease",
        "text": "The initial dose of amantadine depressed locomotor activity in all mouse strains studied with the BALB / C mice being the most sensitive .",
        "entities": [
            "depressed"
        ]
    },
    {
        "id": "2661",
        "type": "disease",
        "text": "The median duration of ATT before ALF was 30 ( 7 - 350 ) days .",
        "entities": [
            "ALF"
        ]
    },
    {
        "id": "2307",
        "type": "disease",
        "text": "A 45 - year - old man , an admitted frequent cocaine user , presented to the Emergency Department ( ED ) on two separate occasions with a history of priapism after cocaine use .",
        "entities": [
            "priapism"
        ]
    },
    {
        "id": "153",
        "type": "disease",
        "text": "Bromocriptine - induced hypotension was unaffected by isoproterenol pretreatment , while tachycardia was reversed to significant bradycardia , an effect that was partly reduced by i . v . domperidone ( 0 . 5 mg / kg ) .",
        "entities": [
            "hypotension",
            "tachycardia",
            "bradycardia"
        ]
    },
    {
        "id": "2279",
        "type": "disease",
        "text": "Alpha - lipoic acid exerts neuroprotective effects against chemotherapy induced neurotoxicity in sensory neurons : it rescues the mitochondrial toxicity and induces the expression of frataxin , an essential mitochondrial protein with anti - oxidant and chaperone properties .",
        "entities": [
            "neurotoxicity",
            "mitochondrial toxicity"
        ]
    },
    {
        "id": "284",
        "type": "disease",
        "text": "Acute cocaine - induced seizures : differential sensitivity of six inbred mouse strains .",
        "entities": [
            "seizures"
        ]
    },
    {
        "id": "8",
        "type": "disease",
        "text": "Orthostatic hypotension was ameliorated 4 days after withdrawal of selegiline and totally abolished 7 days after discontinuation of the drug .",
        "entities": [
            "Orthostatic hypotension"
        ]
    },
    {
        "id": "1555",
        "type": "disease",
        "text": "Finally , percutaneous methods for the exclusion of left atrial appendage are under investigation in high - risk patients .",
        "entities": []
    },
    {
        "id": "4327",
        "type": "disease",
        "text": "Determining testosterone only in cases of low sexual desire or abnormal physical examination would have missed 40 % of the cases with low testosterone , including 37 % of those subsequently improved by androgen therapy .",
        "entities": [
            "low sexual desire"
        ]
    },
    {
        "id": "4058",
        "type": "disease",
        "text": "One of 16 patients ( 6 % ) with prior chemotherapy had a complete response ( CR ) of 31 weeks ' duration ( 95 % CI , 0 % to 30 % ) .",
        "entities": []
    },
    {
        "id": "3967",
        "type": "disease",
        "text": "Three patients on acetazolamide ( 15 % ) developed renal calculi .",
        "entities": [
            "renal calculi"
        ]
    },
    {
        "id": "2063",
        "type": "disease",
        "text": "In addition , the role of dopamine receptors in mediating nicotine - induced locomotor stimulation was investigated by examining the effects of selective D1 and D2 dopamine receptor antagonists on activity induced by nicotine .",
        "entities": []
    },
    {
        "id": "2526",
        "type": "disease",
        "text": "METHOD : This was a cross - sectional study of 85 patients from a lithium clinic who received different dose schedules .",
        "entities": []
    },
    {
        "id": "4117",
        "type": "disease",
        "text": "Ballistic and choreic dyskinesia were markedly ameliorated , whereas dystonia was not .",
        "entities": [
            "dyskinesia",
            "dystonia"
        ]
    },
    {
        "id": "185",
        "type": "disease",
        "text": "In male animals , repeated apomorphine treatment induced a gradual development of aggressive behavior as evidenced by the increased intensity of aggressiveness and shortened latency before the first attack toward the opponent .",
        "entities": [
            "aggressive behavior",
            "aggressiveness"
        ]
    },
    {
        "id": "4272",
        "type": "disease",
        "text": "A low incidence of cardiovascular malformations was observed after exposure to each of the four calcium channel blockers , but this incidence was statistically significant only for verapamil and nifedipine .",
        "entities": [
            "cardiovascular malformations"
        ]
    },
    {
        "id": "1414",
        "type": "disease",
        "text": "Cerebral vasculitis associated with amphetamine abuse is well documented , and in rare cases ischaemic stroke has been reported after methylphenidate intake in children .",
        "entities": [
            "Cerebral vasculitis",
            "amphetamine abuse",
            "ischaemic stroke"
        ]
    },
    {
        "id": "839",
        "type": "disease",
        "text": "Neither L - arginine transport into mononuclear cells ( placebo vs active , 26 . 3 + / - 3 . 6 vs 29 . 0 + / - 2 . 1 pmol / 10 000 cells per 5 minutes , respectively , at an l - arginine concentration of 300 micromol / L ) nor L - arginine extraction in the forearm ( at 80 minutes , placebo vs active , 1 868 904 + / - 434 962 vs 2 013 910 + / - 770 619 disintegrations per minute ) was affected by cortisol treatment ; ie , that L - arginine uptake is not affected by short - term cortisol treatment .",
        "entities": []
    },
    {
        "id": "521",
        "type": "disease",
        "text": "Groups were compared for preoperative laboratory variables , diagnosis , postoperative variables , survival , type of ESRD therapy , and survival from onset of ESRD .",
        "entities": [
            "ESRD",
            "ESRD"
        ]
    },
    {
        "id": "2165",
        "type": "disease",
        "text": "Valvular heart disease in patients with Parkinson ' s disease treated with pergolide .",
        "entities": [
            "Valvular heart disease",
            "Parkinson ' s disease"
        ]
    },
    {
        "id": "2822",
        "type": "disease",
        "text": "Consequently , carmofur - induced leukoencephalopathy may uncommonly result in organic personality syndrome in the residual state .",
        "entities": [
            "leukoencephalopathy",
            "organic personality syndrome"
        ]
    },
    {
        "id": "3037",
        "type": "disease",
        "text": "Clotiazepam - induced acute hepatitis .",
        "entities": [
            "hepatitis"
        ]
    },
    {
        "id": "465",
        "type": "disease",
        "text": "Seventy - three percent ( 73 / 99 ) of the study participants were treated for headache and 70 % ( 70 / 99 ) for nausea .",
        "entities": [
            "headache",
            "nausea"
        ]
    },
    {
        "id": "211",
        "type": "disease",
        "text": "CONCLUSIONS : DBP , but not SBP , reduction was associated with neurological worsening after the intravenous administration of high - dose nimodipine after acute stroke .",
        "entities": [
            "acute stroke"
        ]
    },
    {
        "id": "4088",
        "type": "disease",
        "text": "We conclude that lidocaine reduces the incidence and severity of propofol injection pain in ambulatory patients whereas thiopentone only reduces its severity .",
        "entities": [
            "pain"
        ]
    },
    {
        "id": "4386",
        "type": "disease",
        "text": "( + / - ) - PG - 9 ( 10 - 40 mg kg - 1 i . p . ) was able to prevent amnesia induced by scopolamine ( 1 mg kg - 1 i . p . ) and dicyclomine ( 2 mg kg - 1 i . p . ) in the mouse passive - avoidance test .",
        "entities": [
            "amnesia"
        ]
    },
    {
        "id": "1265",
        "type": "disease",
        "text": "Therefore , when the arrhythmia is present in this population , reversible causes must be identified and resolved .",
        "entities": [
            "arrhythmia"
        ]
    },
    {
        "id": "3344",
        "type": "disease",
        "text": "Several recent studies have stressed the renal sparing features of sulindac , owing to its lack of interference with renal prostacyclin synthesis .",
        "entities": []
    },
    {
        "id": "1545",
        "type": "disease",
        "text": "CONCLUSION : Our results suggest that high - dose testosterone therapy may adversely affect atherosclerosis in postmenopausal women and indicate that androgen replacement in these women may not be harmless .",
        "entities": [
            "atherosclerosis"
        ]
    },
    {
        "id": "2775",
        "type": "disease",
        "text": "RESULTS : We observed a significant decrease in haptoglobin levels at the end of the treatment period .",
        "entities": []
    },
    {
        "id": "4288",
        "type": "disease",
        "text": "Animal studies and mechanistic studies indicate that nicotine could play a role in accelerating atherosclerosis , but evidence among humans is too inadequate to be definitive about such an effect .",
        "entities": [
            "atherosclerosis"
        ]
    },
    {
        "id": "3439",
        "type": "disease",
        "text": "A synergistic effect of etoposide and cyclosporin A was observed in a patient with acute T - lymphocytic leukemia in relapse .",
        "entities": [
            "acute T - lymphocytic leukemia"
        ]
    },
    {
        "id": "124",
        "type": "disease",
        "text": "Despite inducing extensive erythrocyte lysis , TAM does not shift the osmotic fragility curves of erythrocytes .",
        "entities": []
    },
    {
        "id": "2111",
        "type": "disease",
        "text": "Pretreatment with either VPU ( 50 and 100 mg / kg ) or VPA ( 300 and 600 mg / kg ) completely abolished pilocarpine - evoked increases in extracellular glutamate and aspartate .",
        "entities": []
    },
    {
        "id": "2974",
        "type": "disease",
        "text": "Seizure activity due to PTZ and picrotoxin ( PTX ) was significantly decreased ; however , seizure activity due to 3 - mercaptopropionic acid ( MPA ) , bicuculline ( BCC ) , methyl 6 , 7 - dimethoxy - 4 - ethyl - B - carboline - 3 - carboxylate ( DMCM ) , or strychnine ( STR ) was not different from control .",
        "entities": [
            "Seizure",
            "seizure"
        ]
    },
    {
        "id": "1172",
        "type": "disease",
        "text": "RESULTS : Overall , 21 out of 104 patients ( 20 . 2 % ) presented with high frequency sensorineural hearing loss ( SNHL ) , either unilateral or bilateral .",
        "entities": [
            "sensorineural hearing loss",
            "SNHL"
        ]
    },
    {
        "id": "4236",
        "type": "disease",
        "text": "Subsequently , acute cardiac arrest and fatal subarachnoid hemorrhage occurred .",
        "entities": [
            "cardiac arrest",
            "subarachnoid hemorrhage"
        ]
    },
    {
        "id": "4383",
        "type": "disease",
        "text": "( + / - ) - PG - 9 antinociception peaked 15 min after injection and then slowly diminished .",
        "entities": []
    },
    {
        "id": "4470",
        "type": "disease",
        "text": "Twenty - three of the patients had previously taken appetite suppressants , mainly fenfluramines , as compared with only 5 of the controls ( 66 versus 6 % , p < 0 . 0001 ) .",
        "entities": []
    },
    {
        "id": "135",
        "type": "disease",
        "text": "Changes of sodium and ATP affinities of the cardiac ( Na , K ) - ATPase during and after nitric oxide deficient hypertension .",
        "entities": [
            "hypertension"
        ]
    },
    {
        "id": "4157",
        "type": "disease",
        "text": "We describe 3 episodes of microangiopathic hemolytic anemia ( MAHA ) in 2 solid organ recipients under FK506 ( tacrolimus ) therapy .",
        "entities": [
            "microangiopathic hemolytic anemia",
            "MAHA"
        ]
    },
    {
        "id": "577",
        "type": "disease",
        "text": "Zyban caused significant neurological and cardiovascular toxicity in overdose .",
        "entities": [
            "neurological and cardiovascular toxicity",
            "overdose"
        ]
    },
    {
        "id": "1558",
        "type": "disease",
        "text": "Dexamethasone ( Dex ) - induced hypertension is characterized by endothelial dysfunction associated with nitric oxide ( NO ) deficiency and increased superoxide ( O2 - ) production .",
        "entities": [
            "hypertension"
        ]
    },
    {
        "id": "3611",
        "type": "disease",
        "text": "Elevations in the serum GOT and GPT were maximum in the sedentary - isoproterenols and minimum in the exercise - controls .",
        "entities": []
    },
    {
        "id": "1396",
        "type": "disease",
        "text": "Sham - operated rats served as normotensive controls ( 128 + / - 3 mm Hg , n = 8 ) .",
        "entities": []
    },
    {
        "id": "3079",
        "type": "disease",
        "text": "Cerebral infarction occurred in 10 patients ( 22 % ) , intracerebral hemorrhage in 22 ( 49 % ) , and subarachnoid hemorrhage in 13 ( 29 % ) .",
        "entities": [
            "Cerebral infarction",
            "intracerebral hemorrhage",
            "subarachnoid hemorrhage"
        ]
    },
    {
        "id": "3690",
        "type": "disease",
        "text": "Increased density and / or size and PRL content were indicated for the majority of the PRL cell population in both types of separation protocols .",
        "entities": []
    },
    {
        "id": "1315",
        "type": "disease",
        "text": "Whatever was the dose , the central administration of U - II had no effect on body temperature , nociception , apomorphine - induced penile erection and climbing behavior , and stress - induced plasma corticosterone level .",
        "entities": [
            "penile erection"
        ]
    },
    {
        "id": "1298",
        "type": "disease",
        "text": "Current protein - based technology offers a new therapeutic venue by which antibodies bind the drug in the blood stream , inactivating its toxic effects .",
        "entities": []
    },
    {
        "id": "2419",
        "type": "disease",
        "text": "Perceived pain intensity is modulated by attention .",
        "entities": [
            "pain"
        ]
    },
    {
        "id": "1051",
        "type": "disease",
        "text": "Population responses in granule cells of the dentate gyrus were examined in transverse slices of the ventral hippocampus from pilocarpine - treated and untreated mice .",
        "entities": []
    },
    {
        "id": "3256",
        "type": "disease",
        "text": "They are thus more important during absolute hypovolemia than during deliberate hypotension .",
        "entities": [
            "hypovolemia",
            "hypotension"
        ]
    },
    {
        "id": "2640",
        "type": "disease",
        "text": "These results suggest that spasm provocation tests , which use an intracoronary injection of a relatively low dose of methylergonovine , have a high sensitivity in variant angina and the vasoreactivity of the right coronary artery may be greater than that of the other coronary arteries .",
        "entities": [
            "spasm",
            "variant angina"
        ]
    },
    {
        "id": "3214",
        "type": "disease",
        "text": "Adverse cardiac effects during induction chemotherapy treatment with cis - platin and 5 - fluorouracil .",
        "entities": []
    },
    {
        "id": "1963",
        "type": "disease",
        "text": "Cocaine - induced anxiety was also attenuated in Dbh + / - mice following administration of disulfiram , a dopamine beta - hydroxylase ( DBH ) inhibitor .",
        "entities": [
            "anxiety"
        ]
    },
    {
        "id": "4205",
        "type": "disease",
        "text": "Cerebellar volume for the patient group ranged between 67 . 66 and 131 . 08 ml ( mean 108 . 9 ml ) .",
        "entities": []
    },
    {
        "id": "223",
        "type": "disease",
        "text": "A board - certified emergency physician skilled in airway management supervised administration of the anesthetic , and the patients were monitored by a registered nurse .",
        "entities": []
    },
    {
        "id": "3902",
        "type": "disease",
        "text": "During the night clomipramine ingestion altered the complete sleep architecture in that it suppressed REM sleep and the sleep cycles and induced increased wakefulness .",
        "entities": []
    },
    {
        "id": "3869",
        "type": "disease",
        "text": "Rats were treated with a single IV injection of puromycin aminonucleoside , ( PAN , 7 . 5 mg / kg ) and 24 hour urine samples were obtained prior to sacrifice on days 3 , 5 , 7 , 10 , 17 , 27 , 41 ( N = 5 - 10 per group ) .",
        "entities": []
    },
    {
        "id": "2021",
        "type": "disease",
        "text": "Eleven patients progressed during therapy .",
        "entities": []
    },
    {
        "id": "703",
        "type": "disease",
        "text": "The gamma - aminobutyric acid - transmitted thalamocortical circuitry accounts for a major part of the underlying neurophysiology of the absence epilepsy .",
        "entities": [
            "absence epilepsy"
        ]
    },
    {
        "id": "3009",
        "type": "disease",
        "text": "When instilled directly into the bladder , CAA exerts urotoxic effects , it is , however , susceptible to detoxification with mesna .",
        "entities": []
    },
    {
        "id": "2066",
        "type": "disease",
        "text": "The stimulant action of nicotine was blocked by the central nicotinic antagonist mecamylamine but not by the peripheral nicotinic blocker hexamethonium , indicating that the response is probably mediated by central nicotinic receptors .",
        "entities": []
    },
    {
        "id": "1987",
        "type": "disease",
        "text": "There were no suggestions of interactions between clonidine and methylphenidate regarding cardiovascular outcomes .",
        "entities": []
    },
    {
        "id": "1209",
        "type": "disease",
        "text": "Acute reserpine and subchronic haloperidol treatments change synaptosomal brain glutamate uptake and elicit orofacial dyskinesia in rats .",
        "entities": [
            "orofacial dyskinesia"
        ]
    },
    {
        "id": "886",
        "type": "disease",
        "text": "Delirium was inconsistently recognized clinically in milder cases and was associated with increased length - of - stay and higher costs , and inferior clinical outcome .",
        "entities": [
            "Delirium"
        ]
    },
    {
        "id": "110",
        "type": "disease",
        "text": "From such experiments there is evidence that characterization and detection of apomorphine - induced activity in rodents critically depends upon the test conditions employed .",
        "entities": []
    },
    {
        "id": "3856",
        "type": "disease",
        "text": "Because folinic acid was unlikely to be associated with this condition , neurotoxicity due to high - dose 5 - fluorouracil was highly suspected .",
        "entities": [
            "neurotoxicity"
        ]
    },
    {
        "id": "4476",
        "type": "disease",
        "text": "Inappropriate use of carbamazepine and vigabatrin in typical absence seizures .",
        "entities": [
            "absence seizures"
        ]
    },
    {
        "id": "3447",
        "type": "disease",
        "text": "Since adverse reactions are frequent , less than 50 percent of patients are able to continue a particular drug for more than one year .",
        "entities": []
    },
    {
        "id": "2978",
        "type": "disease",
        "text": "The in vitro data suggest that the site responsible for the decrease in seizure activity 24 h after gamma - HCH may be the GABA - A receptor - linked chloride channel .",
        "entities": [
            "seizure"
        ]
    },
    {
        "id": "4329",
        "type": "disease",
        "text": "Only 1 prolactinoma was discovered .",
        "entities": [
            "prolactinoma"
        ]
    },
    {
        "id": "2793",
        "type": "disease",
        "text": "Safety of capecitabine : a review .",
        "entities": []
    },
    {
        "id": "4320",
        "type": "disease",
        "text": "Prolactin results were compared with those of a previous personal cohort of 1 , 340 patients with erectile dysfunction and systematic prolactin determination .",
        "entities": [
            "erectile dysfunction"
        ]
    },
    {
        "id": "4002",
        "type": "disease",
        "text": "Of the 19 patients without sodium bicarbonate added to the medication 11 ( 58 % ) complained of penile pain due to the medication , while only 1 of the 19 men ( 5 % ) who received sodium bicarbonate complained of penile pain .",
        "entities": [
            "penile pain",
            "penile pain"
        ]
    },
    {
        "id": "1806",
        "type": "disease",
        "text": "To develop a novel and effective drug that could enhance cognitive function and neuroprotection , we newly synthesized maltolyl p - coumarate by the esterification of maltol and p - coumaric acid .",
        "entities": []
    },
    {
        "id": "1695",
        "type": "disease",
        "text": "The influence of smoking during pregnancy on the developing cochlea has not been estimated , although smoking has been positively associated with hearing loss in adults .",
        "entities": [
            "hearing loss"
        ]
    },
    {
        "id": "2450",
        "type": "disease",
        "text": "The ocular myasthenia associated with combination therapy of pegylated IFN alpha - 2b and ribavirin for CHC is very rarely reported ; therefore , we present this case with a review of the various eye complications of IFN therapy .",
        "entities": [
            "ocular myasthenia",
            "CHC"
        ]
    },
    {
        "id": "129",
        "type": "disease",
        "text": "However , TAM induces release of peripheral proteins of membrane - cytoskeleton and cytosol proteins essentially bound to band 3 .",
        "entities": []
    },
    {
        "id": "4235",
        "type": "disease",
        "text": "The sudden onset of respiratory distress , rash , and a history of a new medicine led the two paramedics on the scene to administer subcutaneous epinephrine .",
        "entities": [
            "respiratory distress",
            "rash"
        ]
    },
    {
        "id": "723",
        "type": "disease",
        "text": "METHODS : For a period of 2 weeks , CsA 15 mg / kg / day ( given orally ) , FK506 3 . 0 mg / kg / day ( given orally ) or SRL 0 . 4 mg / kg / day ( given intraperitoneally ) was administered once a day as these doses have earlier been found to achieve a significant immunosuppressive effect in Sprague - Dawley rats .",
        "entities": []
    },
    {
        "id": "2792",
        "type": "disease",
        "text": "The findings of this study indicate that the drug is able to antagonize impairment of attention and memory induced by scopolamine .",
        "entities": [
            "impairment of attention and memory"
        ]
    },
    {
        "id": "2191",
        "type": "disease",
        "text": "Mitochondrial injury may be involved in the progression of heart failure caused by adriamycin via the autophagy pathway .",
        "entities": [
            "heart failure"
        ]
    },
    {
        "id": "1924",
        "type": "disease",
        "text": "Cognitive ability was assessed by the Mini - Mental State Examination ( MMSE ) .",
        "entities": []
    },
    {
        "id": "3156",
        "type": "disease",
        "text": "We report a case of severe hypertension with an occluded renal artery to a solitary kidney , who developed sudden deterioration of renal function following treatment with captopril .",
        "entities": [
            "hypertension",
            "sudden deterioration of renal function"
        ]
    },
    {
        "id": "3315",
        "type": "disease",
        "text": "We report the case of a patient in whom troleandomycin - induced hepatitis was followed by prolonged anicteric cholestasis .",
        "entities": [
            "hepatitis",
            "cholestasis"
        ]
    },
    {
        "id": "2570",
        "type": "disease",
        "text": "The administration of ephedrine led to a similar increase in MAP ( 53 + / - 9 to 79 + / - 8 mmHg ; P < 0 . 001 ) , restored CO ( 3 . 2 + / - 1 . 2 to 5 . 0 + / - 1 . 3 l min ( - 1 ) ) , and preserved S ( c ) O ( 2 ) .",
        "entities": []
    },
    {
        "id": "1391",
        "type": "disease",
        "text": "No abnormality in CCO activity was observed through histochemistry .",
        "entities": []
    },
    {
        "id": "4544",
        "type": "disease",
        "text": "The maximal NGF contents obtained by PG - 9 were 17 . 6 - fold of the control value .",
        "entities": []
    },
    {
        "id": "3834",
        "type": "disease",
        "text": "Safety and side - effects of alprazolam .",
        "entities": []
    },
    {
        "id": "4051",
        "type": "disease",
        "text": "European Organization for Research and Treatment of Cancer Gastrointestinal Treat Cancer Cooperative Group .",
        "entities": [
            "Cancer",
            "Cancer"
        ]
    },
    {
        "id": "4189",
        "type": "disease",
        "text": "The observed positive impact of nifedipine on reducing the nephrotoxicity associated with tacrolimus in liver transplant recipients should be an important factor in selecting an agent to treat hypertension in this population .",
        "entities": [
            "nephrotoxicity",
            "hypertension"
        ]
    },
    {
        "id": "3092",
        "type": "disease",
        "text": "All rats in the sodium - depleted group had histopathological evidence of patchy tubular cytoplasmic degeneration in tubules that was not observed in any normal - salt or salt - loaded rat .",
        "entities": []
    },
    {
        "id": "3639",
        "type": "disease",
        "text": "D - penicillamine - induced angiopathy in rats .",
        "entities": [
            "angiopathy"
        ]
    },
    {
        "id": "2271",
        "type": "disease",
        "text": "No thrombi or signs of microangiopathies were observed in arterial vessels .",
        "entities": [
            "thrombi",
            "microangiopathies"
        ]
    },
    {
        "id": "2953",
        "type": "disease",
        "text": "While she was weak , 2 - Hz repetitive stimulation revealed a decrement without significant facilitation at rapid rates or after exercise , suggesting postsynaptic neuromuscular blockade .",
        "entities": [
            "postsynaptic neuromuscular blockade"
        ]
    },
    {
        "id": "3941",
        "type": "disease",
        "text": "Skin tests were performed with benzylpenicilloyl - poly - L - lysine ( BPO - PLL ) , benzylpenicilloate , benzylpenicillin ( PG ) , ampicillin ( AMP ) , and AX .",
        "entities": []
    },
    {
        "id": "3964",
        "type": "disease",
        "text": "Acetazolamide - induced nephrolithiasis : implications for treatment of neuromuscular disorders .",
        "entities": [
            "nephrolithiasis",
            "neuromuscular disorders"
        ]
    },
    {
        "id": "3",
        "type": "disease",
        "text": "This unwanted effect on postural blood pressure was not the result of underlying autonomic failure .",
        "entities": []
    },
    {
        "id": "10",
        "type": "disease",
        "text": "CONCLUSION : This study confirms our previous finding that selegiline in combination with L - dopa is associated with selective orthostatic hypotension .",
        "entities": [
            "orthostatic hypotension"
        ]
    },
    {
        "id": "2654",
        "type": "disease",
        "text": "Prospective studies on ATT - ALF are lacking .",
        "entities": [
            "ALF"
        ]
    },
    {
        "id": "3633",
        "type": "disease",
        "text": "Of the 82 patients studied after 1 year , 23 had primary and 59 recurrent disease .",
        "entities": []
    },
    {
        "id": "379",
        "type": "disease",
        "text": "BACKGROUND : An association has been found between transplant glomerulopathy ( TG ) and reduplication of peritubular capillary basement membranes ( PTCR ) .",
        "entities": [
            "transplant glomerulopathy",
            "TG"
        ]
    },
    {
        "id": "941",
        "type": "disease",
        "text": "Depression and sexual dysfunction have been related to side effects of topical beta - blockers .",
        "entities": [
            "Depression",
            "sexual dysfunction"
        ]
    },
    {
        "id": "3616",
        "type": "disease",
        "text": "The effect of a widely used organic solvent , polyethylene glycol 400 ( PEG 400 ) , on the toxic action of an acute or chronic treatment with adriamycin ( ADR ) was evaluated in mice .",
        "entities": []
    },
    {
        "id": "3285",
        "type": "disease",
        "text": "A Cambodian woman with hemoglobin E trait ( AE ) and leprosy developed a Heinz body hemolytic anemia while taking a dose of dapsone ( 50 mg / day ) not usually associated with clinical hemolysis .",
        "entities": [
            "leprosy",
            "hemolytic anemia",
            "hemolysis"
        ]
    },
    {
        "id": "4274",
        "type": "disease",
        "text": "The site of common side effects of sumatriptan .",
        "entities": []
    },
    {
        "id": "1917",
        "type": "disease",
        "text": "CONCLUSION : In patients with risk factors , e . g . regular consumption of alcohol , liver failure is possible when therapeutic doses are ingested .",
        "entities": [
            "liver failure"
        ]
    },
    {
        "id": "1220",
        "type": "disease",
        "text": "Clinical and experimental studies also suggest that situations causing gallbladder dysfunction , such as fasting , may have a role for the development of pseudolithiasis .",
        "entities": [
            "gallbladder dysfunction",
            "pseudolithiasis"
        ]
    },
    {
        "id": "4446",
        "type": "disease",
        "text": "A healthy 17 - year - old male received standard intermittent doses of pethidine via a patient - controlled analgesia ( PCA ) pump for management of postoperative pain control .",
        "entities": [
            "postoperative pain"
        ]
    },
    {
        "id": "1296",
        "type": "disease",
        "text": "Evaluation of the anticocaine monoclonal antibody GNC92H2 as an immunotherapy for cocaine overdose .",
        "entities": [
            "cocaine overdose"
        ]
    },
    {
        "id": "1599",
        "type": "disease",
        "text": "Proteinuria after conversion to sirolimus in renal transplant recipients .",
        "entities": [
            "Proteinuria"
        ]
    },
    {
        "id": "831",
        "type": "disease",
        "text": "Hydrocortisone acetate ( 50 mg ) was given orally every 6 hours for 24 hours after a 5 - day fixed - salt diet ( 150 mmol / d ) .",
        "entities": []
    },
    {
        "id": "1566",
        "type": "disease",
        "text": "Vascular eNOS mRNA was assessed by semi - quantitative reverse transcription - polymerase chain reaction .",
        "entities": []
    },
    {
        "id": "3889",
        "type": "disease",
        "text": "CASE SUMMARY : A 13 - year - old boy was treated with ampicillin and gentamicin because of suspected septicemia .",
        "entities": [
            "septicemia"
        ]
    },
    {
        "id": "1284",
        "type": "disease",
        "text": "BE - Induced seizures occurred more frequently and had significantly longer latencies than those induced by equimolar amounts of cocaine .",
        "entities": [
            "seizures"
        ]
    },
    {
        "id": "1752",
        "type": "disease",
        "text": "This , together with our previous findings that allopurinol failed to prevent adrenocorticotrophic hormone induced hypertension , suggests that XO activity is not a major determinant of GC - HT in the rat .",
        "entities": [
            "hypertension",
            "HT"
        ]
    },
    {
        "id": "3956",
        "type": "disease",
        "text": "Reversal by phenylephrine of the beneficial effects of intravenous nitroglycerin in patients with acute myocardial infarction .",
        "entities": [
            "acute myocardial infarction"
        ]
    },
    {
        "id": "2862",
        "type": "disease",
        "text": "Moreover , detailed ophthalmologic and audiologic studies disclosed abnormalities in 7 more asymptomatic patients .",
        "entities": []
    },
    {
        "id": "2725",
        "type": "disease",
        "text": "The amount of nephrin was reduced in both diseased and normal areas .",
        "entities": []
    },
    {
        "id": "4434",
        "type": "disease",
        "text": "Repeated trimipramine induces dopamine D2 / D3 and alpha1 - adrenergic up - regulation .",
        "entities": []
    },
    {
        "id": "2371",
        "type": "disease",
        "text": "It was also shown that both products of inducible NO synthase and neuronal NO synthase activation as well as bradykinin are involved in hyperalgesia produced by vincristine .",
        "entities": [
            "hyperalgesia"
        ]
    },
    {
        "id": "2891",
        "type": "disease",
        "text": "In brain membranes from spontaneously hypertensive rats clonidine , 10 ( - 8 ) to 10 ( - 5 ) M , did not influence stereoselective binding of [ 3H ] - naloxone ( 8 nM ) , and naloxone , 10 ( - 8 ) to 10 ( - 4 ) M , did not influence clonidine - suppressible binding of [ 3H ] - dihydroergocryptine ( 1 nM ) .",
        "entities": [
            "hypertensive"
        ]
    },
    {
        "id": "1743",
        "type": "disease",
        "text": "Thirty male Sprague - Dawley rats were divided randomly into four treatment groups : saline , dexamethasone ( dex ) , allopurinol plus saline , and allopurinol plus dex .",
        "entities": []
    },
    {
        "id": "2254",
        "type": "disease",
        "text": "Doxorubicin - induced nephropathy leads to epithelial sodium channel ( ENaC ) - dependent volume retention and renal fibrosis .",
        "entities": [
            "nephropathy",
            "volume retention",
            "fibrosis"
        ]
    },
    {
        "id": "2558",
        "type": "disease",
        "text": "The patient developed weakness , lethargy , and shortness of breath 2 days after starting therapy with omeprazole .",
        "entities": [
            "lethargy",
            "shortness of breath"
        ]
    },
    {
        "id": "246",
        "type": "disease",
        "text": "Analgesic effect of intravenous ketamine in cancer patients on morphine therapy : a randomized , controlled , double - blind , crossover , double - dose study .",
        "entities": [
            "cancer"
        ]
    },
    {
        "id": "3321",
        "type": "disease",
        "text": "Visual and auditory neurotoxicity was previously documented in 42 of 89 patients with transfusion - dependent anemia who were receiving iron chelation therapy with daily subcutaneous deferoxamine .",
        "entities": [
            "Visual and auditory neurotoxicity",
            "anemia"
        ]
    },
    {
        "id": "3907",
        "type": "disease",
        "text": "METHODS : We sent a questionnaire concerning complications of indocyanine green to 32 institutions in Japan , which were selected on the basis of the client list from the Topcon Company , which manufactures the indocyanine green fundus camera .",
        "entities": []
    },
    {
        "id": "1911",
        "type": "disease",
        "text": "RELEVANCE TO CLINICAL PRACTICE : When administering subcutaneous heparin injections , it is important to extend the duration of the injection .",
        "entities": []
    },
    {
        "id": "881",
        "type": "disease",
        "text": "METHODS : We used computerized pharmacy records to identify all adult psychiatric inpatients treated with clozapine ( 1995 - 96 ) , reviewed their medical records to score incidence and severity of delirium , and tested associations with potential risk factors .",
        "entities": [
            "psychiatric",
            "delirium"
        ]
    },
    {
        "id": "1453",
        "type": "disease",
        "text": "Carbachol concentrations in serum and urine on day 1 and 2 of hospital admission were analysed by HPLC - mass spectrometry .",
        "entities": []
    },
    {
        "id": "1877",
        "type": "disease",
        "text": "Ritonavir increased the expression of the scavenger receptor , CD36 mRNA , responsible for the uptake of LDL .",
        "entities": []
    },
    {
        "id": "1306",
        "type": "disease",
        "text": "The electrocardiograms ( ECG ) of 99 cocaine - abusing patients were compared with the ECGs of 50 schizophrenic controls .",
        "entities": [
            "schizophrenic"
        ]
    },
    {
        "id": "2527",
        "type": "disease",
        "text": "Patients were admitted to the hospital for measurement of lithium level , creatinine clearance , urine volume , and maximum osmolality .",
        "entities": []
    },
    {
        "id": "3918",
        "type": "disease",
        "text": "Her medical history included coronary artery disease with previous myocardial infarctions , hypertension , and diabetes mellitus .",
        "entities": [
            "coronary artery disease",
            "myocardial infarctions",
            "hypertension",
            "diabetes mellitus"
        ]
    },
    {
        "id": "1745",
        "type": "disease",
        "text": "Systolic blood pressures ( SBP ) and bodyweights were recorded each alternate day .",
        "entities": []
    },
    {
        "id": "2039",
        "type": "disease",
        "text": "Concomitant IS consisted of mycophenolate mofetil + / - steroids .",
        "entities": []
    },
    {
        "id": "1986",
        "type": "disease",
        "text": "RESULTS : There were more incidents of bradycardia in subjects treated with clonidine compared with those not treated with clonidine ( 17 . 5 % versus 3 . 4 % ; p = . 02 ) , but no other significant group differences regarding electrocardiogram and other cardiovascular outcomes .",
        "entities": [
            "bradycardia"
        ]
    },
    {
        "id": "1935",
        "type": "disease",
        "text": "A higher residual serum concentration of temazepam correlated with a lower MMSE sum score after adjustment for confounding variables .",
        "entities": []
    },
    {
        "id": "1824",
        "type": "disease",
        "text": "RESULTS : A 20 - year - old male with schizophrenia developed a sudden onset of myocarditis after commencement of clozapine .",
        "entities": [
            "schizophrenia",
            "myocarditis"
        ]
    },
    {
        "id": "79",
        "type": "disease",
        "text": "New chemotherapy combinations with higher activity and lower toxicity are needed for elderly patients with advanced NSCLC .",
        "entities": [
            "toxicity",
            "NSCLC"
        ]
    },
    {
        "id": "3080",
        "type": "disease",
        "text": "These data indicate that ( 1 ) the apparent incidence of stroke related to cocaine use is increasing ; ( 2 ) cocaine - associated stroke occurs primarily in young adults ; ( 3 ) stroke may follow any route of cocaine administration ; ( 4 ) stroke after cocaine use is frequently associated with intracranial aneurysms and arteriovenous malformations ; and ( 5 ) in cocaine - associated stroke , the frequency of intracranial hemorrhage exceeds that of cerebral infarction .",
        "entities": [
            "stroke",
            "stroke",
            "stroke",
            "stroke",
            "intracranial aneurysms",
            "arteriovenous malformations",
            "stroke",
            "intracranial hemorrhage",
            "cerebral infarction"
        ]
    },
    {
        "id": "2037",
        "type": "disease",
        "text": "In cardiac transplantation , the incidence of proteinuria associated with Srl is unknown .",
        "entities": [
            "proteinuria"
        ]
    },
    {
        "id": "509",
        "type": "disease",
        "text": "The adjusted odds ratio was 2 . 5 ( 95 percent confidence interval , 1 . 5 to 4 . 1 ) among women who used second - generation oral contraceptives and 1 . 3 ( 95 percent confidence interval , 0 . 7 to 2 . 5 ) among those who used third - generation oral contraceptives .",
        "entities": []
    },
    {
        "id": "336",
        "type": "disease",
        "text": "The cardiotoxicity of conventional anthracycline therapy highlights a need to search for methods that are highly sensitive and capable of predicting cardiac dysfunction .",
        "entities": [
            "cardiotoxicity",
            "cardiac dysfunction"
        ]
    },
    {
        "id": "3474",
        "type": "disease",
        "text": "Since nonsteroidal anti - inflammatory agents interfere with this compensatory mechanism and may cause acute renal failure , they should be used with caution in such patients .",
        "entities": [
            "acute renal failure"
        ]
    },
    {
        "id": "544",
        "type": "disease",
        "text": "INTERPRETATION : Tranexamic acid retains its convulsive action within FS .",
        "entities": [
            "convulsive"
        ]
    },
    {
        "id": "2121",
        "type": "disease",
        "text": "Control rats received corn oil only .",
        "entities": []
    },
    {
        "id": "1944",
        "type": "disease",
        "text": "She noticed hoarseness and distally accentuated motor and sensory dysfunction after she had recovered from this state .",
        "entities": [
            "hoarseness"
        ]
    },
    {
        "id": "3483",
        "type": "disease",
        "text": "The remaining patient in the series developed fulminant hepatitis when the drug was accidentally recommenced 1 year after a prior episode of methyldopa - induced hepatitis .",
        "entities": [
            "fulminant hepatitis",
            "hepatitis"
        ]
    },
    {
        "id": "4199",
        "type": "disease",
        "text": "Magnetic resonance volumetry of the cerebellum in epileptic patients after phenytoin overdosages .",
        "entities": [
            "epileptic",
            "overdosages"
        ]
    },
    {
        "id": "2678",
        "type": "disease",
        "text": "Central nervous system complications during treatment of acute lymphoblastic leukemia in a single pediatric institution .",
        "entities": [
            "Central nervous system complications",
            "acute lymphoblastic leukemia"
        ]
    },
    {
        "id": "2956",
        "type": "disease",
        "text": "Although paralysis after magnesium administration has been described in patients with known myasthenia gravis , it has not previously been reported to be the initial or only manifestation of the disease .",
        "entities": [
            "paralysis",
            "myasthenia gravis"
        ]
    },
    {
        "id": "4025",
        "type": "disease",
        "text": "15 cases of cimetidine - associated mental confusion have been reported .",
        "entities": [
            "confusion"
        ]
    },
    {
        "id": "3887",
        "type": "disease",
        "text": "Erythema multiforme and hypersensitivity myocarditis caused by ampicillin .",
        "entities": [
            "Erythema multiforme",
            "hypersensitivity myocarditis"
        ]
    },
    {
        "id": "2395",
        "type": "disease",
        "text": "High - signal intensity lesions on DWI tended to show low signal intensity on ADC map ( 3 / 4 ) , but in one patient , high signal intensity was shown at bilateral dentate nuclei on not only DWI but also ADC map .",
        "entities": []
    },
    {
        "id": "755",
        "type": "disease",
        "text": "Octreotide - induced hypoxemia and pulmonary hypertension in premature neonates .",
        "entities": [
            "hypoxemia",
            "pulmonary hypertension"
        ]
    },
    {
        "id": "324",
        "type": "disease",
        "text": "Calcineurin - inhibitor induced pain syndrome ( CIPS ) : a severe disabling complication after organ transplantation .",
        "entities": [
            "pain",
            "CIPS"
        ]
    },
    {
        "id": "4511",
        "type": "disease",
        "text": "Myocardial concentrations of calcium also increased significantly ( 12 . 0 vs . 5 . 0 mg . per 100 Gm . of fat - free dry weight ) .",
        "entities": []
    },
    {
        "id": "2687",
        "type": "disease",
        "text": "Different mechanisms have been suggested for cocaine toxicity including an increase in oxidative stress but the association between oxidative status in the brain and cocaine induced - behaviour is poorly understood .",
        "entities": [
            "toxicity"
        ]
    },
    {
        "id": "292",
        "type": "disease",
        "text": "Additional studies of these murine strains may be useful for investigating genetic influences on cocaine - induced seizures .",
        "entities": [
            "seizures"
        ]
    },
    {
        "id": "1425",
        "type": "disease",
        "text": "These data lend further support to the proposal that cognitive processes mediated by the prefrontal cortex may be impaired by recreational ecstasy use .",
        "entities": []
    },
    {
        "id": "3985",
        "type": "disease",
        "text": "Dup 753 prevents the development of puromycin aminonucleoside - induced nephrosis .",
        "entities": [
            "nephrosis"
        ]
    },
    {
        "id": "2107",
        "type": "disease",
        "text": "Acute effects of N - ( 2 - propylpentanoyl ) urea on hippocampal amino acid neurotransmitters in pilocarpine - induced seizure in rats .",
        "entities": [
            "seizure"
        ]
    },
    {
        "id": "2354",
        "type": "disease",
        "text": "Capsaicin injection reliably induced a dose - dependent flare ( p < 0 . 001 ) without any difference within or across sessions .",
        "entities": []
    },
    {
        "id": "3201",
        "type": "disease",
        "text": "In the five rats that developed somatic rigidity , ICP and CVP increased significantly above baseline ( delta ICP 7 . 5 + / - 1 . 0 mmHg , delta CVP 5 . 9 + / - 1 . 3 mmHg ) .",
        "entities": [
            "somatic rigidity"
        ]
    },
    {
        "id": "1602",
        "type": "disease",
        "text": "We retrospectively examined the records of 25 renal transplant patients , who developed or displayed increased proteinuria after SRL conversion .",
        "entities": [
            "proteinuria"
        ]
    },
    {
        "id": "1401",
        "type": "disease",
        "text": "Renal plasma flow increased , but albumin excretion and glomerulosclerosis did not change after enalapril treatment .",
        "entities": [
            "glomerulosclerosis"
        ]
    },
    {
        "id": "4302",
        "type": "disease",
        "text": "We aimed to test whether HCFCs 123 and 124 can result in serious liver disease .",
        "entities": [
            "liver disease"
        ]
    },
    {
        "id": "1386",
        "type": "disease",
        "text": "Mitochondrial abnormalities have been associated with several aspects of epileptogenesis , such as energy generation , control of cell death , neurotransmitter synthesis , and free radical ( FR ) production .",
        "entities": [
            "Mitochondrial abnormalities",
            "death"
        ]
    },
    {
        "id": "4280",
        "type": "disease",
        "text": "BACKGROUND : Although intravitreal aminoglycosides have substantially improved visual prognosis in endophthalmitis , macular infarction may impair full visual recovery .",
        "entities": [
            "endophthalmitis",
            "infarction"
        ]
    },
    {
        "id": "3399",
        "type": "disease",
        "text": "The development of tolerance to the muscular rigidity produced by morphine was studied in rats .",
        "entities": [
            "muscular rigidity"
        ]
    },
    {
        "id": "2291",
        "type": "disease",
        "text": "Myoglobinuria was also observed following the 7 . 0 mg / kg dose .",
        "entities": [
            "Myoglobinuria"
        ]
    },
    {
        "id": "1786",
        "type": "disease",
        "text": "To this day , transcriptome analysis has been performed in a rat model of LID [ Neurobiol . Dis . , 17 ( 2004 ) , 219 ] but information regarding the proteome is still lacking .",
        "entities": [
            "LID"
        ]
    },
    {
        "id": "2813",
        "type": "disease",
        "text": "RESULTS : Bilateral infusions of neurotensin into the globus pallidus reversed haloperidol - induced parkinsonian catalepsy in rats .",
        "entities": [
            "parkinsonian catalepsy"
        ]
    },
    {
        "id": "898",
        "type": "disease",
        "text": "They offer protection against seizures in a range of models and seem to inhibit certain stages of drug dependence in preclinical assessments .",
        "entities": [
            "seizures",
            "drug dependence"
        ]
    },
    {
        "id": "3341",
        "type": "disease",
        "text": "Most side effects were mild and related to the GI tract .",
        "entities": []
    },
    {
        "id": "3968",
        "type": "disease",
        "text": "Extracorporeal lithotripsy successfully removed a renal calculus in one patient and surgery removed a staghorn calculus in another , permitting continued treatment .",
        "entities": [
            "renal calculus",
            "calculus"
        ]
    },
    {
        "id": "821",
        "type": "disease",
        "text": "In each patient who had abnormalities on the initial MR study , a follow - up MR study was performed 1 month later .",
        "entities": []
    },
    {
        "id": "3626",
        "type": "disease",
        "text": "A multicenter study was performed in 110 patients with superficial transitional cell carcinoma of the bladder .",
        "entities": [
            "carcinoma of the bladder"
        ]
    },
    {
        "id": "1960",
        "type": "disease",
        "text": "METHODS : In this study , we evaluated the performance of dopamine beta - hydroxylase knockout ( Dbh - / - ) mice , which lack norepinephrine ( NE ) , in the elevated plus maze ( EPM ) to examine the contribution of noradrenergic signaling to cocaine - induced anxiety .",
        "entities": [
            "anxiety"
        ]
    },
    {
        "id": "4009",
        "type": "disease",
        "text": "Of those positive for p24 antigen at the commencement of the study 67 % showed a positive response , and this was most likely in those with CD4 + lymphocyte subset counts above 100 mm3 .",
        "entities": []
    },
    {
        "id": "3449",
        "type": "disease",
        "text": "Patients treated with alkylating agents have an increased risk of development of acute nonlymphocytic leukemia , and both alkylating agents and azathioprine are associated with the development of non - Hodgkin ' s lymphoma .",
        "entities": [
            "acute nonlymphocytic leukemia",
            "non - Hodgkin ' s lymphoma"
        ]
    },
    {
        "id": "1395",
        "type": "disease",
        "text": "Six weeks after clipping of one renal artery , hypertensive rats ( 178 + / - 4 mm Hg ) were randomly assigned to three groups : untreated hypertensive controls ( n = 8 ) , enalapril - treated ( n = 8 ) , or nitrendipine - treated ( n = 10 ) .",
        "entities": [
            "hypertensive",
            "hypertensive"
        ]
    },
    {
        "id": "4240",
        "type": "disease",
        "text": "The goal of this study was to determine the role of synthesis / release of bradykinin to activate B2 receptors in disruption of the blood - brain barrier during acute hypertension .",
        "entities": [
            "hypertension"
        ]
    },
    {
        "id": "1926",
        "type": "disease",
        "text": "Data on use of BZDs / RDs before admission , current medications and discharge diagnoses were collected from medical records .",
        "entities": []
    },
    {
        "id": "2278",
        "type": "disease",
        "text": "Our results demonstrate that both cisplatin and paclitaxel cause early mitochondrial impairment with loss of membrane potential and induction of autophagic vacuoles in neurons .",
        "entities": [
            "mitochondrial impairment"
        ]
    },
    {
        "id": "2776",
        "type": "disease",
        "text": "Hemoglobin levels also decreased but insignificantly by treatment .",
        "entities": []
    },
    {
        "id": "2589",
        "type": "disease",
        "text": "Total ASEX scores were significantly lower , i . e . better , among men who received bupropion than placebo , at 15 . 5 ( 4 . 3 ) vs 21 . 5 ( 4 . 7 ) ( P = 0 . 002 ) .",
        "entities": []
    },
    {
        "id": "662",
        "type": "disease",
        "text": "Crossover comparison of efficacy and preference for rizatriptan 10 mg versus ergotamine / caffeine in migraine .",
        "entities": [
            "migraine"
        ]
    },
    {
        "id": "3349",
        "type": "disease",
        "text": "Drug - induced arterial spasm relieved by lidocaine .",
        "entities": [
            "spasm"
        ]
    },
    {
        "id": "237",
        "type": "disease",
        "text": "Treatments have included discontinuation or reduction of cyclosporine dose with or without concurrent plasma exchange , plasma infusion , anticoagulation , and intravenous immunoglobulin G infusion .",
        "entities": []
    },
    {
        "id": "2366",
        "type": "disease",
        "text": "Bradykinin receptors antagonists and nitric oxide synthase inhibitors in vincristine and streptozotocin induced hyperalgesia in chemotherapy and diabetic neuropathy rat model .",
        "entities": [
            "hyperalgesia",
            "diabetic neuropathy"
        ]
    },
    {
        "id": "2204",
        "type": "disease",
        "text": "Therefore , certain limitations for malaria prophylaxis and treatment with mefloquine are recommended .",
        "entities": [
            "malaria"
        ]
    },
    {
        "id": "762",
        "type": "disease",
        "text": "We believe the results of those studies may have been affected by residual confounding .",
        "entities": []
    },
    {
        "id": "2249",
        "type": "disease",
        "text": "Within 14 days of the oral bisphosphonate ( alendronate sodium ) administration , the amount of daily urinary protein increased rapidly up to 12 . 8 g with acute renal failure .",
        "entities": [
            "acute renal failure"
        ]
    },
    {
        "id": "1767",
        "type": "disease",
        "text": "METHODS : The study group comprised 40 patients undergoing Sestamibi - SPECT / dobutamine stress test .",
        "entities": []
    },
    {
        "id": "3712",
        "type": "disease",
        "text": "The purpose of this study was to evaluate the neurologic consequences of deliberate subarachnoid injection of large volumes of 2 - chloroprocaine - CE in experimental animals .",
        "entities": []
    },
    {
        "id": "4308",
        "type": "disease",
        "text": "INTERPRETATION : Repeated exposure of human beings to HCFCs 123 and 124 can result in serious liver injury in a large proportion of the exposed population .",
        "entities": [
            "liver injury"
        ]
    },
    {
        "id": "4143",
        "type": "disease",
        "text": "At the same time , the number of heparan sulphate anionic sites and the total anionic site surface ( number of anionic sites x mean anionic site surface ) in the lamina rara externa of the glomerular basement membrane was reduced by 19 % ( p < 0 . 021 ) and by 26 % ( p < 0 . 02 ) , respectively .",
        "entities": []
    },
    {
        "id": "1076",
        "type": "disease",
        "text": "Estrogen replacement ( 17beta - estradiol subcutaneous pellet , 14 . 2 microg / day , 12 wk ) of Ovx rats restored the hemodynamic and locomotor effects of alpha - methyldopa to sham - operated levels .",
        "entities": []
    },
    {
        "id": "1154",
        "type": "disease",
        "text": "RESULTS : During a mean follow - up of 3 . 3 years , raloxifene was associated with an increased risk for venous thromboembolism ( relative risk [ RR ] 2 . 1 ; 95 % confidence interval [ CI ] 1 . 2 - 3 . 8 ) .",
        "entities": [
            "venous thromboembolism"
        ]
    },
    {
        "id": "3194",
        "type": "disease",
        "text": "Both patients recovered quickly after stopping glyburide therapy and have remained well for a follow - up period of 1 year .",
        "entities": []
    },
    {
        "id": "4439",
        "type": "disease",
        "text": "In the acute experiment TRI ( given i . p . ) does not antagonize the reserpine hypothermia in mice and does not potentiate the 5 - hydroxytryptophan head twitches in rats .",
        "entities": [
            "hypothermia"
        ]
    },
    {
        "id": "481",
        "type": "disease",
        "text": "No changes were found in other cohorts .",
        "entities": []
    },
    {
        "id": "3467",
        "type": "disease",
        "text": "Delirium , which may be induced by tricyclic drug therapy in the elderly , can be caused by tricyclics with low anticholinergic potency .",
        "entities": [
            "Delirium"
        ]
    },
    {
        "id": "1879",
        "type": "disease",
        "text": "Treatment with E2 , however , failed to prevent these increases at the mRNA level .",
        "entities": []
    },
    {
        "id": "254",
        "type": "disease",
        "text": "These episodes reversed after the administration of diazepam 1 mg intravenously .",
        "entities": []
    },
    {
        "id": "4",
        "type": "disease",
        "text": "The aims of this study were to confirm our previous findings in a separate cohort of patients and to determine the time course of the cardiovascular consequences of stopping selegiline in the expectation that this might shed light on the mechanisms by which the drug causes orthostatic hypotension .",
        "entities": [
            "orthostatic hypotension"
        ]
    },
    {
        "id": "2849",
        "type": "disease",
        "text": "The dose - limiting toxic effect was transient noncumulative granulocytopenia .",
        "entities": [
            "granulocytopenia"
        ]
    },
    {
        "id": "1426",
        "type": "disease",
        "text": "Phase II study of the amsacrine analogue CI - 921 ( NSC 343499 ) in non - small cell lung cancer .",
        "entities": [
            "non - small cell lung cancer"
        ]
    },
    {
        "id": "4053",
        "type": "disease",
        "text": "PATIENTS AND METHODS : Forty - six eligible patients with measurable lesions were included and were stratified according to previous chemotherapy .",
        "entities": []
    },
    {
        "id": "825",
        "type": "disease",
        "text": "The remaining 1 patient ( 20 . 0 % ) showed lower than normal ADC value and showed incomplete resolution with cortical laminar necrosis .",
        "entities": [
            "cortical laminar necrosis"
        ]
    },
    {
        "id": "3981",
        "type": "disease",
        "text": "After starting PGE1 or TMP , MAP and rate pressure product ( RPP ) decreased significantly compared with preinfusion values ( P < 0 . 01 ) , and the degree of hypotension due to PGE1 remained constant until 60 min after its discontinuation .",
        "entities": [
            "hypotension"
        ]
    },
    {
        "id": "1546",
        "type": "disease",
        "text": "Optimising stroke prevention in non - valvular atrial fibrillation .",
        "entities": [
            "stroke",
            "atrial fibrillation"
        ]
    },
    {
        "id": "944",
        "type": "disease",
        "text": "During the six - month follow up , depression was quantified through the Beck and Zung - Conde scales every two months .",
        "entities": [
            "depression"
        ]
    },
    {
        "id": "4543",
        "type": "disease",
        "text": "PG - 9 was also able to increase the amount of NGF secreted in vitro by astrocytes in a dose - dependent manner .",
        "entities": []
    },
    {
        "id": "3430",
        "type": "disease",
        "text": "Twenty children with acute lymphoblastic leukemia who developed meningeal disease were treated with a high - dose intravenous methotrexate regimen that was designed to achieve and maintain CSF methotrexate concentrations of 10 ( - 5 ) mol / L without the need for concomitant intrathecal dosing .",
        "entities": [
            "acute lymphoblastic leukemia",
            "meningeal disease"
        ]
    },
    {
        "id": "2561",
        "type": "disease",
        "text": "The mechanism by which omeprazole caused the patient ' s hemolytic anemia is uncertain , but physicians should be alerted to this possible adverse effect .",
        "entities": [
            "hemolytic anemia"
        ]
    },
    {
        "id": "3696",
        "type": "disease",
        "text": "The extrapolated 6 - hr serum concentration of cimetidine per unit dose , after intravenous cimetidine , increased with age of the patients .",
        "entities": []
    },
    {
        "id": "1417",
        "type": "disease",
        "text": "We conclude that methylphenidate mediated vasculitis should be considered in patients with neurological symptoms and a history of methylphenidate therapy .",
        "entities": [
            "vasculitis"
        ]
    },
    {
        "id": "4035",
        "type": "disease",
        "text": "In all of 7 patients examined acutely , gallbladder contractility was inhibited after a single 100 - micrograms injection .",
        "entities": []
    },
    {
        "id": "2809",
        "type": "disease",
        "text": "OBJECTIVE : The globus pallidus plays a critical role in movement regulation .",
        "entities": []
    },
    {
        "id": "2231",
        "type": "disease",
        "text": "Recommendations to avoid potential cranial nerve deficits from papaverine are provided .",
        "entities": [
            "cranial nerve deficits"
        ]
    },
    {
        "id": "2836",
        "type": "disease",
        "text": "We recommend objective neuromuscular monitoring during the first ECT .",
        "entities": []
    },
    {
        "id": "4123",
        "type": "disease",
        "text": "These studies suggest that both phenacetin and acetaminophen may contribute to the burden of ESRD , with the risk of the latter being somewhat less than that of the former .",
        "entities": [
            "ESRD"
        ]
    },
    {
        "id": "3464",
        "type": "disease",
        "text": "Reduction in the dosage of amiodarone resulted in the disappearance of the sinoatrial block and the persistence of asymptomatic sinus bradycardia .",
        "entities": [
            "sinoatrial block",
            "sinus bradycardia"
        ]
    },
    {
        "id": "934",
        "type": "disease",
        "text": "Five of 8 patients ( 63 % ) improved during fusidic acid treatment : 3 at two weeks and 2 after four weeks .",
        "entities": []
    },
    {
        "id": "505",
        "type": "disease",
        "text": "BACKGROUND : An association between the use of oral contraceptives and the risk of myocardial infarction has been found in some , but not all , studies .",
        "entities": [
            "myocardial infarction"
        ]
    },
    {
        "id": "4402",
        "type": "disease",
        "text": "Prospective multicentre studies with a large population and a long follow - up should be performed in order to evaluate the incidence of this unusual side effect .",
        "entities": []
    },
    {
        "id": "2087",
        "type": "disease",
        "text": "While side effects were rare , those experienced after theophylline use did involve the cardiovascular and gastrointestinal systems .",
        "entities": [
            "cardiovascular and gastrointestinal systems"
        ]
    },
    {
        "id": "1244",
        "type": "disease",
        "text": "Other causes include drug - related ( cyclosporine , tacrolimus ) toxicity , procoagulant status , and antibody - mediated rejection .",
        "entities": [
            "toxicity"
        ]
    },
    {
        "id": "2105",
        "type": "disease",
        "text": "NIN correlated with blood oxygen level - dependent ( BOLD ) activity levels in a midpontine site in the posterior basis pontis .",
        "entities": [
            "NIN"
        ]
    },
    {
        "id": "1989",
        "type": "disease",
        "text": "Drowsiness was common on clonidine , but generally resolved by 6 to 8 weeks .",
        "entities": [
            "Drowsiness"
        ]
    },
    {
        "id": "3204",
        "type": "disease",
        "text": "These observations suggest that rigidity should be prevented when alfentanil , and , presumably , other opiates , are used in the anesthetic management of patients with ICP problems .",
        "entities": [
            "rigidity"
        ]
    },
    {
        "id": "1062",
        "type": "disease",
        "text": "RESULTS : The median cumulative doses of cyclophosphamide among cases ( n = 11 ) and controls ( n = 25 ) were 113 g and 25 g , respectively .",
        "entities": []
    },
    {
        "id": "2272",
        "type": "disease",
        "text": "Blood and urine cultures did not show any bacterial growth .",
        "entities": []
    },
    {
        "id": "626",
        "type": "disease",
        "text": "METHODS : Cholinergic convulsant sensitivity was examined in alcohol - na ve Withdrawal Seizure - Prone ( WSP ) and - Resistant ( WSR ) mice .",
        "entities": [
            "Seizure"
        ]
    },
    {
        "id": "4042",
        "type": "disease",
        "text": "Depression is a major clinical feature of Parkinson ' s disease .",
        "entities": [
            "Depression",
            "Parkinson ' s disease"
        ]
    },
    {
        "id": "3393",
        "type": "disease",
        "text": "Oral diphenhydramine and prednisone were ineffective in preventing the recurrence of the allergic reaction .",
        "entities": [
            "allergic reaction"
        ]
    },
    {
        "id": "277",
        "type": "disease",
        "text": "Many new serotonergic antidepressants have been introduced over the past decade .",
        "entities": []
    },
    {
        "id": "1821",
        "type": "disease",
        "text": "Acute myocarditis associated with clozapine .",
        "entities": [
            "myocarditis"
        ]
    },
    {
        "id": "262",
        "type": "disease",
        "text": "The emergence of new active drugs might translate into more effective regimens for the treatment of this disease .",
        "entities": []
    },
    {
        "id": "3133",
        "type": "disease",
        "text": "This treatment with CBZ had no apparent adverse effect on folate concentrations in the rat , and , indeed , the folate concentration increased in liver after 6 weeks of treatment and in plasma at 8 weeks of treatment .",
        "entities": []
    },
    {
        "id": "3886",
        "type": "disease",
        "text": "In conclusion , octreotide induced gall stones are generally small , multiple , and cholesterol rich although , in common with spontaneous gall stone disease , at presentation some patients will have a blocked cystic duct and some gall stones containing calcium .",
        "entities": [
            "gall stones",
            "gall stone disease",
            "gall stones"
        ]
    },
    {
        "id": "2155",
        "type": "disease",
        "text": "Fentanyl is a commonly used supplement that may contribute to this , although it may also improve analgesia .",
        "entities": []
    },
    {
        "id": "1276",
        "type": "disease",
        "text": "Clinicians must be diligent when interviewing patients about their drug therapy histories and include questions about their use of herbal products and dietary supplements .",
        "entities": []
    },
    {
        "id": "682",
        "type": "disease",
        "text": "CASE : A 58 - year - old man received an intracarotid injection of carboplatin for recurrent glioblastomas in his left temporal lobe .",
        "entities": [
            "glioblastomas"
        ]
    },
    {
        "id": "3078",
        "type": "disease",
        "text": "Intracranial aneurysms or arteriovenous malformations were present in 17 of 32 patients studied angiographically or at autopsy ; cerebral vasculitis was present in two patients .",
        "entities": [
            "Intracranial aneurysms",
            "arteriovenous malformations",
            "cerebral vasculitis"
        ]
    },
    {
        "id": "3359",
        "type": "disease",
        "text": "In the present experiment calcitonin decreased locomotor activity when locally injected into the same sites where it decreases food intake .",
        "entities": []
    },
    {
        "id": "2188",
        "type": "disease",
        "text": "RESULTS : 3MA significantly improved cardiac function and reduced mitochondrial injury .",
        "entities": []
    },
    {
        "id": "4193",
        "type": "disease",
        "text": "The patient with nitrazepam overdose and two of those with chlormethiazole intoxication conformed to the criteria of ' alpha coma ' , showing non - reactive generalized or frontally predominant alpha activity in the EEG .",
        "entities": [
            "overdose",
            "coma"
        ]
    },
    {
        "id": "875",
        "type": "disease",
        "text": "The development of severe anemia at 6 months post - CAB was predictable by the reduction of Hb baseline value of more than 2 . 5 g / dl after 3 months of CAB ( p = 0 . 01 ) .",
        "entities": [
            "anemia"
        ]
    },
    {
        "id": "556",
        "type": "disease",
        "text": "These findings suggest that overgrowth of the exencephalic neural tissue causes the altered distribution patterns of vessels , subsequent peripheral circulatory failure and / or hemorrhaging in various parts of the exencephalic head , leading to the multiple modes of tissue reduction during transformation from exencephaly to anencephaly .",
        "entities": [
            "exencephalic",
            "circulatory failure",
            "hemorrhaging",
            "exencephalic",
            "exencephaly",
            "anencephaly"
        ]
    },
    {
        "id": "3803",
        "type": "disease",
        "text": "The effects of varying the extracellular concentrations of Na and Ca ( [ Na ] o and [ Ca ] o ) on both , the spontaneous beating and the negative chronotropic action of verapamil , were studied in the isolated rat atria .",
        "entities": []
    },
    {
        "id": "2854",
        "type": "disease",
        "text": "The area under the curve was 537 + / - 149 ng / ml x hours , volume of distribution ( Vd ) 3504 + / - 644 l / m2 , and total clearance ( ClT ) was 204 + 39 . 3 l / hour / m2 .",
        "entities": []
    },
    {
        "id": "714",
        "type": "disease",
        "text": "Male rats that received prenatal dexamethasone on days 15 and 16 , 17 and 18 , and 13 and 14 of gestation had elevated blood pressures at 6 months of age ; the latter group did not have a reduction in glomerular number .",
        "entities": [
            "elevated blood pressures",
            "reduction in glomerular number"
        ]
    },
    {
        "id": "1424",
        "type": "disease",
        "text": "The latter two deficits remained significant after controlling for other drug use .",
        "entities": []
    },
    {
        "id": "3465",
        "type": "disease",
        "text": "Desipramine - induced delirium at \" subtherapeutic \" concentrations : a case report .",
        "entities": [
            "delirium"
        ]
    },
    {
        "id": "3200",
        "type": "disease",
        "text": "Following instrumentation , halothane was discontinued and alfentanil ( 125 mu / kg ) administered iv during emergence from halothane anesthesia .",
        "entities": []
    },
    {
        "id": "840",
        "type": "disease",
        "text": "We conclude that cortisol - induced increases in blood pressure are not associated with abnormalities in the l - arginine transport system .",
        "entities": [
            "increases in blood pressure"
        ]
    },
    {
        "id": "787",
        "type": "disease",
        "text": "T - cell stimulation by therapeutic concentration of ticlopidine was demonstrated in vitro in the patients , but not in healthy controls .",
        "entities": []
    },
    {
        "id": "4405",
        "type": "disease",
        "text": "BACKGROUND : Recent evidence suggests that transient neurologic symptoms ( TNSs ) frequently follow lidocaine spinal anesthesia but are infrequent with bupivacaine .",
        "entities": [
            "transient neurologic symptoms",
            "TNSs"
        ]
    },
    {
        "id": "993",
        "type": "disease",
        "text": "Basal CGRP concentration was significantly higher and platelet 5 - HT content tended to be lower in subjects who experienced a migraine attack .",
        "entities": [
            "migraine"
        ]
    },
    {
        "id": "1356",
        "type": "disease",
        "text": "Safety profile of a nicotine lozenge compared with that of nicotine gum in adult smokers with underlying medical conditions : a 12 - week , randomized , open - label study .",
        "entities": []
    },
    {
        "id": "802",
        "type": "disease",
        "text": "The time courses of urinary sodium excretion , plasma aldosterone concentration and proteinuria were studied in male Sprague - Dawley rats treated with a single dose of either PAN or vehicle .",
        "entities": [
            "proteinuria"
        ]
    },
    {
        "id": "1747",
        "type": "disease",
        "text": "5 .",
        "entities": []
    },
    {
        "id": "439",
        "type": "disease",
        "text": "We report on two fatal cases of accidental intrathecal vincristine instillation in a 5 - year old girl with recurrent acute lymphoblastic leucemia and a 57 - year old man with lymphoblastic lymphoma .",
        "entities": [
            "acute lymphoblastic leucemia",
            "lymphoblastic lymphoma"
        ]
    },
    {
        "id": "1954",
        "type": "disease",
        "text": "Neuropsychological testing showed impaired word fluency , psychomotor speed and working memory .",
        "entities": [
            "impaired word fluency , psychomotor speed and working memory"
        ]
    },
    {
        "id": "2718",
        "type": "disease",
        "text": "Permeability , ultrastructural changes , and distribution of novel proteins in the glomerular barrier in early puromycin aminonucleoside nephrosis .",
        "entities": [
            "nephrosis"
        ]
    },
    {
        "id": "2108",
        "type": "disease",
        "text": "The present study aimed to investigate the anticonvulsant activity as well as the effects on the level of hippocampal amino acid neurotransmitters ( glutamate , aspartate , glycine and GABA ) of N - ( 2 - propylpentanoyl ) urea ( VPU ) in comparison to its parent compound , valproic acid ( VPA ) .",
        "entities": []
    },
    {
        "id": "2738",
        "type": "disease",
        "text": "Dopamine D2 receptors were elevated in the striatum , whereas serotonin 2C , but not serotonin 1A , receptors were elevated in the orbital frontal cortex .",
        "entities": []
    },
    {
        "id": "248",
        "type": "disease",
        "text": "Animal and clinical studies have suggested that N - methyl - D - aspartate ( NMDA ) antagonists , such as ketamine , may be effective in improving opioid analgesia in difficult pain syndromes , such as neuropathic pain .",
        "entities": [
            "pain",
            "neuropathic pain"
        ]
    },
    {
        "id": "2795",
        "type": "disease",
        "text": "AREAS COVERED IN THIS REVIEW : This article reviews the pharmacology and efficacy of capecitabine with a special emphasis on its safety .",
        "entities": []
    },
    {
        "id": "2339",
        "type": "disease",
        "text": "In contrast to the systemic renin - angiotensin system , which is suppressed in response to HS in male DS , intrarenal angiotensinogen expression is increased , and intrarenal levels of ANG II are not suppressed .",
        "entities": []
    },
    {
        "id": "921",
        "type": "disease",
        "text": "Lithium also caused proteinuria and systolic hypertension in absence of glomerulosclerosis .",
        "entities": [
            "proteinuria",
            "hypertension",
            "glomerulosclerosis"
        ]
    },
    {
        "id": "4200",
        "type": "disease",
        "text": "The aim of this study was to evaluate the relationship between phenytoin medication and cerebellar atrophy in patients who had experienced clinical intoxication .",
        "entities": [
            "cerebellar atrophy"
        ]
    },
    {
        "id": "3641",
        "type": "disease",
        "text": "Male Sprague - Dawley rats were treated with D - penicillamine ( D - pen ) 500 mg / kg / day for 10 or 42 days .",
        "entities": []
    },
    {
        "id": "1737",
        "type": "disease",
        "text": "Role of xanthine oxidase in dexamethasone - induced hypertension in rats .",
        "entities": [
            "hypertension"
        ]
    },
    {
        "id": "108",
        "type": "disease",
        "text": "These studies were conducted to examine the differential response to a drug challenge under varied experimental test conditions routinely employed to study drug - induced behavioral and neurophysiological responses in rodents .",
        "entities": []
    },
    {
        "id": "3685",
        "type": "disease",
        "text": "Over a range of 1 - 150 days of DES treatment , pairs of control and DES - treated rats were sacrificed , and their pituitaries dissociated enzymatically into single - cell preparations .",
        "entities": []
    },
    {
        "id": "2810",
        "type": "disease",
        "text": "Previous studies have indicated that the globus pallidus receives neurotensinergic innervation from the striatum , and systemic administration of a neurotensin analog could produce antiparkinsonian effects .",
        "entities": []
    },
    {
        "id": "1129",
        "type": "disease",
        "text": "Routine EKG monitoring during infusional cyclophosphamide did not predict CHF development .",
        "entities": [
            "CHF"
        ]
    },
    {
        "id": "4135",
        "type": "disease",
        "text": "The reports illustrate the need for clinicians to consider acetaminophen in patients with hypotension of unknown origin .",
        "entities": [
            "hypotension"
        ]
    },
    {
        "id": "3984",
        "type": "disease",
        "text": "These results suggest that PGE1 may be preferable to TMP for hypotensive anaesthesia in spinal surgery because TMP decreased EBF .",
        "entities": [
            "hypotensive"
        ]
    },
    {
        "id": "3403",
        "type": "disease",
        "text": "The rigidity was considerably decreased in both groups after 20 days ' treatment .",
        "entities": [
            "rigidity"
        ]
    },
    {
        "id": "1790",
        "type": "disease",
        "text": "Out of these 67 proteins , LID significantly changed the expression level of five proteins : alphabeta - crystalin , gamma - enolase , guanidoacetate methyltransferase , vinculin , and proteasome alpha - 2 subunit .",
        "entities": [
            "LID"
        ]
    },
    {
        "id": "2673",
        "type": "disease",
        "text": "Trial medication was 2 . 5 mg enalapril or 0 . 5 prazosin .",
        "entities": []
    },
    {
        "id": "844",
        "type": "disease",
        "text": "In ICH intrastriatally induced by 0 . 014 - unit , 0 . 070 - unit , and 0 . 350 - unit collagenase , the amount of bleeding was measured using a hemoglobin assay developed in the present study and was compared with the morphologically determined hematoma volume .",
        "entities": [
            "ICH",
            "bleeding",
            "hematoma"
        ]
    },
    {
        "id": "1060",
        "type": "disease",
        "text": "Nested within the cohort , a matched case - control study was performed to estimate the association between cyclophosphamide and bladder cancer using odds ratios ( ORs ) as relative risk .",
        "entities": [
            "bladder cancer"
        ]
    },
    {
        "id": "573",
        "type": "disease",
        "text": "Two patients developed severe cardiac arrhythmias , including one patient who was resuscitated following a cardiac arrest .",
        "entities": [
            "cardiac arrhythmias",
            "cardiac arrest"
        ]
    },
    {
        "id": "4014",
        "type": "disease",
        "text": "Peripheral neuropathy occurred in 12 patients and pancreatitis in six .",
        "entities": [
            "Peripheral neuropathy",
            "pancreatitis"
        ]
    },
    {
        "id": "2825",
        "type": "disease",
        "text": "BACKGROUND : patients undergoing electroconvulsive therapy ( ECT ) often receive succinylcholine as part of the anesthetic procedure .",
        "entities": []
    },
    {
        "id": "3246",
        "type": "disease",
        "text": "During nitroprusside infusion low levels of CPAP do not markedly alter cardiovascular dynamics , but high levels of CPAP ( 10 cm H2O ) , while decreasing QS / QT , produce marked decreases in arterial blood pressure and cardiac output .",
        "entities": [
            "decreases in arterial blood pressure and cardiac output"
        ]
    },
    {
        "id": "252",
        "type": "disease",
        "text": "This effect was more relevant in patients treated with higher doses .",
        "entities": []
    },
    {
        "id": "4282",
        "type": "disease",
        "text": "RESULTS : Endophthalmitis resolved with improvement in visual acuity to 6 / 24 at three months .",
        "entities": [
            "Endophthalmitis"
        ]
    },
    {
        "id": "2334",
        "type": "disease",
        "text": "This study shows that prolonged analgesic treatment in Fischer 344 rats causes progressive and irreversible damage to the interstitial matrix and type 1 interstitial cells leading to RPN .",
        "entities": [
            "RPN"
        ]
    },
    {
        "id": "588",
        "type": "disease",
        "text": "In contrast , podocalyxin did not change significantly at this time .",
        "entities": []
    },
    {
        "id": "2830",
        "type": "disease",
        "text": "The duration of apnea was compared with published data on normal subjects .",
        "entities": [
            "apnea"
        ]
    },
    {
        "id": "757",
        "type": "disease",
        "text": "Pulmonary hypertension developed after administration of a somatostatin analogue , octreotide , to enhance resolution of the fistula .",
        "entities": [
            "Pulmonary hypertension",
            "fistula"
        ]
    },
    {
        "id": "4547",
        "type": "disease",
        "text": "Therefore , PG - 9 could represent a potential useful drug able to improve the function of impaired cognitive processes .",
        "entities": []
    },
    {
        "id": "315",
        "type": "disease",
        "text": "He was hospitalized for a myocardial infarction with pulmonary edema , treated with high - dose diuretics .",
        "entities": [
            "myocardial infarction",
            "pulmonary edema"
        ]
    },
    {
        "id": "2245",
        "type": "disease",
        "text": "Clinicians should be aware of potential hepatotoxicity with simvastatin - ezetimibe especially in elderly patients and should carefully monitor serum aminotransferase levels when starting therapy and titrating the dosage .",
        "entities": [
            "hepatotoxicity"
        ]
    },
    {
        "id": "3123",
        "type": "disease",
        "text": "It is suggested that the patient had sulfasalazine - induced lupus , which manifested with serositis and pulmonary parenchymal involvement in the absence of joint symptoms .",
        "entities": [
            "lupus",
            "serositis"
        ]
    },
    {
        "id": "459",
        "type": "disease",
        "text": "Study participants were randomized to receive 10 mg of prochlorperazine administered intravenously by means of 2 - minute push ( bolus group ) or 10 mg diluted in 50 mL of normal saline solution administered by means of intravenous infusion during a 15 - minute period ( infusion group ) .",
        "entities": []
    },
    {
        "id": "296",
        "type": "disease",
        "text": "Adults chronically treated with angiotensin converting enzyme inhibitors may have a limited ability to respond to hypotension when the sympathetic response is simultaneously blocked .",
        "entities": [
            "hypotension"
        ]
    },
    {
        "id": "748",
        "type": "disease",
        "text": "Maximal cTnI ( pg / ml ) and cTnT levels were significantly increased in DOX rats compared with controls ( p = 0 . 006 , 0 . 007 ) .",
        "entities": []
    },
    {
        "id": "2146",
        "type": "disease",
        "text": "TAC has been shown to be a potent immunosuppressive agent for solid organ transplantation in pediatrics .",
        "entities": []
    },
    {
        "id": "1616",
        "type": "disease",
        "text": "Mean urinary protein of patients who returned to dialysis was 1 . 26 ( 0 . 5 to 3 . 5 ) g / d before and 4 . 7 ( 3 to 12 ) g / d after conversion ( P = . 01 ) .",
        "entities": []
    },
    {
        "id": "4322",
        "type": "disease",
        "text": "Endocrine therapy consisted of testosterone heptylate or human chorionic gonadotropin for hypogonadism and bromocriptine for hyperprolactinemia .",
        "entities": [
            "hypogonadism",
            "hyperprolactinemia"
        ]
    },
    {
        "id": "2573",
        "type": "disease",
        "text": "BACKGROUND : Direct thrombin inhibitors ( DTIs ) provide an alternative method of anticoagulation for patients with a history of heparin - induced thrombocytopenia ( HIT ) or HIT with thrombosis ( HITT ) undergoing cardiopulmonary bypass ( CPB ) .",
        "entities": [
            "thrombocytopenia",
            "HIT",
            "HIT",
            "thrombosis",
            "HITT"
        ]
    },
    {
        "id": "3817",
        "type": "disease",
        "text": "Clinical examinations and skin , oral and parenteral challenges with different corticosteroids and ELISA tests were performed .",
        "entities": []
    },
    {
        "id": "1476",
        "type": "disease",
        "text": "DCE ( 200 , 400 mg / kg , p . o . ) showed significant improvement in memory scores of young and aged mice .",
        "entities": []
    },
    {
        "id": "2095",
        "type": "disease",
        "text": "METH depleted DA , caused microglial activation , and increased body temperature in CX3CR1 knockout mice to the same extent and over the same time course seen in wild - type controls .",
        "entities": []
    },
    {
        "id": "2180",
        "type": "disease",
        "text": "Adriamycin - induced autophagic cardiomyocyte death plays a pathogenic role in a rat model of heart failure .",
        "entities": [
            "death",
            "heart failure"
        ]
    },
    {
        "id": "1462",
        "type": "disease",
        "text": "Respiratory insufficiency was further worsened by Proteus mirabilis infection and severe bronchoconstriction .",
        "entities": [
            "Respiratory insufficiency",
            "Proteus mirabilis infection"
        ]
    },
    {
        "id": "940",
        "type": "disease",
        "text": "Changes in depressive status associated with topical beta - blockers .",
        "entities": [
            "depressive"
        ]
    },
    {
        "id": "538",
        "type": "disease",
        "text": "METHOD : FS containing aprotinin or different concentrations of tAMCA ( 0 . 5 - 47 . 5 mg / ml ) were applied to the pial surface of the cortex of anaesthetized rats .",
        "entities": []
    },
    {
        "id": "4517",
        "type": "disease",
        "text": "Clinical and histopathologic examination of renal allografts treated with tacrolimus ( FK506 ) for at least one year .",
        "entities": []
    },
    {
        "id": "3169",
        "type": "disease",
        "text": "These episodes are asymptomatic and reversible when therapy is discontinued .",
        "entities": []
    },
    {
        "id": "209",
        "type": "disease",
        "text": "Patients with a DBP reduction of > or = 20 % in the high - dose group had a significantly increased adjusted OR for the compound outcome variable death or dependency ( Barthel Index < 60 ) ( n / N = 25 / 26 , OR 10 . 16 , 95 % CI 1 . 02 to 101 . 74 ) and death alone ( n / N = 9 / 26 , OR 4 . 336 , 95 % CI 1 . 131 16 . 619 ) compared with all placebo patients ( n / N = 62 / 92 and 14 / 92 , respectively ) .",
        "entities": [
            "DBP reduction",
            "death",
            "death"
        ]
    },
    {
        "id": "4375",
        "type": "disease",
        "text": "The expression of arginine vasopressin ( AVP ) gene in the paraventricular ( PVN ) and supraoptic nuclei ( SON ) was investigated in rats with lithium ( Li ) - induced polyuria , using in situ hybridization histochemistry and radioimmunoassay .",
        "entities": [
            "polyuria"
        ]
    },
    {
        "id": "1620",
        "type": "disease",
        "text": "The possibility of de novo glomerular pathology under SRL treatment requires further investigation by renal biopsy .",
        "entities": []
    },
    {
        "id": "2117",
        "type": "disease",
        "text": "Studies concerning with pathogenesis of gastric hemorrhage and mucosal ulceration produced in atherosclerotic rats are lacking .",
        "entities": [
            "gastric hemorrhage",
            "atherosclerotic"
        ]
    },
    {
        "id": "4293",
        "type": "disease",
        "text": "Iatrogenically induced intractable atrioventricular reentrant tachycardia after verapamil and catheter ablation in a patient with Wolff - Parkinson - White syndrome and idiopathic dilated cardiomyopathy .",
        "entities": [
            "atrioventricular reentrant tachycardia",
            "Wolff - Parkinson - White syndrome",
            "idiopathic dilated cardiomyopathy"
        ]
    },
    {
        "id": "661",
        "type": "disease",
        "text": "Finally , moral issues relating to the testing of potential cocaine users will be addressed .",
        "entities": []
    },
    {
        "id": "3034",
        "type": "disease",
        "text": "Untreated group 3 rats exhibited a progressive reduction in GFR ( 0 . 35 + / - 0 . 08 ml / min at 4 months , 0 . 27 + / - 0 . 07 ml / min at 6 months ) .",
        "entities": []
    },
    {
        "id": "2777",
        "type": "disease",
        "text": "In contrast with the literature , serum levels of angiogenesis factors did not change significantly by pegylated interferon and ribavirin therapy .",
        "entities": []
    },
    {
        "id": "87",
        "type": "disease",
        "text": "NRA0160 and clozapine significantly reversed the disruption of prepulse inhibition ( PPI ) in rats produced by apomorphine .",
        "entities": []
    },
    {
        "id": "1272",
        "type": "disease",
        "text": "When discharged less than 24 hours later , he was receiving metoprolol and aspirin , with follow - up plans for echocardiography and nuclear imaging to assess perfusion .",
        "entities": []
    },
    {
        "id": "2280",
        "type": "disease",
        "text": "In conclusion mitochondrial toxicity is an early common event both in paclitaxel and cisplatin induced neurotoxicity .",
        "entities": [
            "mitochondrial toxicity",
            "neurotoxicity"
        ]
    },
    {
        "id": "1937",
        "type": "disease",
        "text": "Long - term use was associated with daytime and night - time symptoms indicative of poorer health and potentially caused by the adverse effects of these drugs .",
        "entities": []
    },
    {
        "id": "3407",
        "type": "disease",
        "text": "The results suggest that rigidity , which is assumed to be due to an action of morphine in the striatum , can be antagonized by another process leading to dopaminergic activation in the striatum .",
        "entities": [
            "rigidity"
        ]
    },
    {
        "id": "1182",
        "type": "disease",
        "text": "Therefore , we studied the predictive effect of renal ACE activity for the severity of renal damage induced by a single injection of adriamycin in rats .",
        "entities": [
            "renal damage"
        ]
    },
    {
        "id": "841",
        "type": "disease",
        "text": "Amount of bleeding and hematoma size in the collagenase - induced intracerebral hemorrhage rat model .",
        "entities": [
            "bleeding",
            "hematoma",
            "intracerebral hemorrhage"
        ]
    },
    {
        "id": "740",
        "type": "disease",
        "text": "RESULTS : Eighteen of the DOX rats died prematurely of general toxicity during the 9 - week period .",
        "entities": [
            "toxicity"
        ]
    },
    {
        "id": "3045",
        "type": "disease",
        "text": "The results obtained indicate that with all three carcinogens , administration of 5 - AzC during repair synthesis increased the incidence of initiated hepatocytes , for example 10 - 20 foci / cm2 in 5 - AzC and carcinogen - treated rats compared with 3 - 5 foci / cm2 in rats treated with carcinogen only .",
        "entities": []
    },
    {
        "id": "1104",
        "type": "disease",
        "text": "alpha3 + / - mice were partially resistant to nicotine - induced seizures when compared to wild - type littermates .",
        "entities": [
            "seizures"
        ]
    },
    {
        "id": "4477",
        "type": "disease",
        "text": "Carbamazepine and vigabatrin are contraindicated in typical absence seizures .",
        "entities": [
            "absence seizures"
        ]
    },
    {
        "id": "842",
        "type": "disease",
        "text": "The aggravated risk on intracerebral hemorrhage ( ICH ) with drugs used for stroke patients should be estimated carefully .",
        "entities": [
            "intracerebral hemorrhage",
            "ICH",
            "stroke"
        ]
    },
    {
        "id": "3903",
        "type": "disease",
        "text": "As the relative increase in PRL secretion expressed as a percentage of the mean did not significantly differ between the night and day time studies ( 46 + / - 19 % vs 34 + / - 10 % ) , it can be concluded that the observed sleep disturbance did not interfere with the drug action per se .",
        "entities": [
            "sleep disturbance"
        ]
    },
    {
        "id": "1045",
        "type": "disease",
        "text": "Periodic withdrawal of pyridoxine was associated with return of the hyperkinesis .",
        "entities": [
            "hyperkinesis"
        ]
    },
    {
        "id": "4519",
        "type": "disease",
        "text": "METHODS : Twenty - six renal allograft biopsy specimens from 1 9 renal transplant patients who underwent transplantations between 1991 and 1993 were evaluated .",
        "entities": []
    },
    {
        "id": "4365",
        "type": "disease",
        "text": "Ticlopidine - induced aplastic anemia : report of three Chinese patients and review of the literature .",
        "entities": [
            "aplastic anemia"
        ]
    },
    {
        "id": "778",
        "type": "disease",
        "text": "PATIENTS : Seventy men , aged 50 - 80 years , with advanced androgen - independent prostate cancer .",
        "entities": [
            "prostate cancer"
        ]
    },
    {
        "id": "1055",
        "type": "disease",
        "text": "These data support the hypothesis that SE - induced mossy fiber sprouting and synaptic reorganization are relevant characteristics of seizure development in these murine strains , resembling rat models of human temporal lobe epilepsy .",
        "entities": [
            "SE",
            "seizure",
            "temporal lobe epilepsy"
        ]
    },
    {
        "id": "323",
        "type": "disease",
        "text": "This case report highlights the fact that the angiotensin II receptor antagonist losartan can cause serious unexpected complications in patients with renovascular disease and should be used with extreme caution in this setting .",
        "entities": [
            "renovascular disease"
        ]
    },
    {
        "id": "4257",
        "type": "disease",
        "text": "CONCLUSIONS : The venlafaxine overdose in our patient resulted in a single episode of generalized seizure but elicited no further sequelae .",
        "entities": [
            "overdose",
            "seizure"
        ]
    },
    {
        "id": "1108",
        "type": "disease",
        "text": "The influence of sevoflurane on lidocaine - induced convulsions was studied in cats .",
        "entities": [
            "convulsions"
        ]
    },
    {
        "id": "160",
        "type": "disease",
        "text": "Previous investigations have determined that , in response to clonidine , ultrasound production increases through the 2nd - week postpartum and decreases thereafter .",
        "entities": []
    },
    {
        "id": "1350",
        "type": "disease",
        "text": "The nitric oxide ( NO ) inhibitor nitro - L - arginine methyl ester ( L - NAME ) may act as an otoprotectant against high - frequency hearing loss caused by gentamicin , but further studies are needed to confirm this . Aminoglycoside antibiotics are still widely used by virtue of their efficacy and low cost .",
        "entities": [
            "high - frequency hearing loss"
        ]
    },
    {
        "id": "4145",
        "type": "disease",
        "text": "We conclude that in streptozotocin - diabetic rats with an increased urinary albumin excretion , a reduced heparan sulphate charge barrier / density is found at the lamina rara externa of the glomerular basement membrane .",
        "entities": [
            "diabetic"
        ]
    },
    {
        "id": "4166",
        "type": "disease",
        "text": "After MTX administration a significant increase ( p = 0 . 0228 ) in the plasma creatinine concentration and a significant ( p = 0 . 0001 ) decrease in creatinine clearance was noted compared to controls .",
        "entities": []
    },
    {
        "id": "3607",
        "type": "disease",
        "text": "Effects of training on the extent of experimental myocardial infarction in aging rats .",
        "entities": [
            "myocardial infarction"
        ]
    },
    {
        "id": "1483",
        "type": "disease",
        "text": "Therefore , DCE may prove to be a useful remedy for the management of cognitive dysfunctions on account of its multifarious beneficial effects such as , memory improving property , cholesterol lowering property and anticholinesterase activity .",
        "entities": [
            "cognitive dysfunctions"
        ]
    },
    {
        "id": "2041",
        "type": "disease",
        "text": "Before the switch , 11 . 5 % of patients had high - grade proteinuria ( > 1 . 0 g / day ) ; this increased to 22 . 9 % postswitch ( p = 0 . 006 ) .",
        "entities": [
            "proteinuria"
        ]
    },
    {
        "id": "811",
        "type": "disease",
        "text": "RATIONALE : gamma - Vinyl GABA ( GVG ) irreversibly inhibits GABA - transaminase .",
        "entities": []
    },
    {
        "id": "2392",
        "type": "disease",
        "text": "Follow - up MRIs were performed on 5 patients from third to 14th days after discontinuation of metronidazole administration .",
        "entities": []
    },
    {
        "id": "347",
        "type": "disease",
        "text": "Nephrotoxicity of combined cephalothin - gentamicin regimen .",
        "entities": [
            "Nephrotoxicity"
        ]
    },
    {
        "id": "4433",
        "type": "disease",
        "text": "In particular it illustrates the derangements of thyroid function seen in pregnant women with eating disorders and reminds us that when a cause for thyrotoxicosis remains obscure , thyroxine abuse should be considered and explored .",
        "entities": [
            "eating disorders",
            "thyrotoxicosis"
        ]
    },
    {
        "id": "4129",
        "type": "disease",
        "text": "Through 30 years of widespread use , acetaminophen has been shown to be a remarkably safe medication in therapeutic dosages .",
        "entities": []
    },
    {
        "id": "4125",
        "type": "disease",
        "text": "A lower relative risk would be expected for acetaminophen if the risk of both drugs in combination with other analgesics was higher than the risk of either agent alone .",
        "entities": []
    },
    {
        "id": "2414",
        "type": "disease",
        "text": "The anti - dementia effects of s - limonene and s - perillyl alcohol were observed using the passive avoidance test ( PA ) and the open field habituation test ( OFH ) .",
        "entities": [
            "dementia"
        ]
    },
    {
        "id": "1502",
        "type": "disease",
        "text": "Antipsychotic - like profile of thioperamide , a selective H3 - receptor antagonist in mice .",
        "entities": []
    },
    {
        "id": "1972",
        "type": "disease",
        "text": "Estradiol is known to influence expression of the long form of prolactin receptors ( PRL - R ) and components of prolactin ' s signaling pathway .",
        "entities": []
    },
    {
        "id": "750",
        "type": "disease",
        "text": "All markers remained stable in controls .",
        "entities": []
    },
    {
        "id": "620",
        "type": "disease",
        "text": "There was a significant reduction of thymidine incorporation into both erythroid and endothelial cells in cultures pre - treated with IGF - IL - 3 and EPO .",
        "entities": []
    },
    {
        "id": "3561",
        "type": "disease",
        "text": "Isoniazid was the most frequent agent in drug - induced neuropathy .",
        "entities": [
            "neuropathy"
        ]
    },
    {
        "id": "1419",
        "type": "disease",
        "text": "MDMA polydrug users show process - specific central executive impairments coupled with impaired social and emotional judgement processes .",
        "entities": [
            "impaired social and emotional judgement processes"
        ]
    },
    {
        "id": "4208",
        "type": "disease",
        "text": "However , multiple regression for the daily dosage , duration of phenytoin treatment and cerebellar volume revealed a correlation of these parameters .",
        "entities": []
    },
    {
        "id": "3880",
        "type": "disease",
        "text": "In the remaining 12 patients , localised computed tomography of the gall bladder showed that eight had stones with maximum attenuation scores of < 100 Hounsfield units ( values of < 100 HU predict cholesterol rich , dissolvable stones ) .",
        "entities": []
    },
    {
        "id": "1193",
        "type": "disease",
        "text": "Recurrent acute interstitial nephritis induced by azithromycin .",
        "entities": [
            "interstitial nephritis"
        ]
    },
    {
        "id": "2642",
        "type": "disease",
        "text": "AIM : The aim of the documentation of this clinical case is to make clinicians aware of \" meth mouth \" and the medical risks associated with this serious condition .",
        "entities": [
            "meth mouth"
        ]
    },
    {
        "id": "1921",
        "type": "disease",
        "text": "METHODS : A non - randomised clinical study of patients aged > or = 65 years admitted to acute hospital wards during 1 month .",
        "entities": []
    },
    {
        "id": "2403",
        "type": "disease",
        "text": "METHODS : We analyzed the clinical and laboratory information available for all 119 patients transplanted at the Washington Hospital Center between 1999 - 2003 for whom sirolimus was a component of their immunosuppressant regimen .",
        "entities": []
    },
    {
        "id": "4278",
        "type": "disease",
        "text": "In these individuals , side effects are most likely generated superficially in the skin .",
        "entities": []
    },
    {
        "id": "2286",
        "type": "disease",
        "text": "Using this rationale , the 8 - aminoquinoline WR242511 , a potent long - lasting MHb former in rodents and beagle dogs , was studied in the rhesus monkey for advanced development as a potential CN pretreatment .",
        "entities": []
    },
    {
        "id": "2603",
        "type": "disease",
        "text": "The donor - derived GFP ( + ) cells were rarely found in the brains of transplanted epileptic rats .",
        "entities": [
            "epileptic"
        ]
    },
    {
        "id": "2985",
        "type": "disease",
        "text": "The possible beneficial effect of ribavirin during the initial days of AHF is discussed .",
        "entities": [
            "AHF"
        ]
    },
    {
        "id": "635",
        "type": "disease",
        "text": "CONCLUSIONS : These results suggest that differences in cholinergic activity and postsynaptic sensitivity to cholinergic convulsants may be associated with ethanol withdrawal severity and implicate cholinergic mechanisms in alcohol withdrawal .",
        "entities": [
            "convulsants"
        ]
    },
    {
        "id": "4319",
        "type": "disease",
        "text": "Determination was repeated in case of abnormal first results .",
        "entities": []
    },
    {
        "id": "1878",
        "type": "disease",
        "text": "Additionally , ritonavir treatment selectively increased the relative levels of PPARgamma mRNA , a transcription factor responsible for the regulation of CD36 mRNA expression .",
        "entities": []
    },
    {
        "id": "2605",
        "type": "disease",
        "text": "Normalizing effects of modafinil on sleep in chronic cocaine users .",
        "entities": []
    },
    {
        "id": "3086",
        "type": "disease",
        "text": "Arterial PO2 decreased in both groups .",
        "entities": []
    },
    {
        "id": "2288",
        "type": "disease",
        "text": "Health status and MHb levels were monitored following exposure .",
        "entities": []
    },
    {
        "id": "1501",
        "type": "disease",
        "text": "A significant proportion of warfarin - related cerebral haemorrhages might have been prevented if greater caution had been taken when prescribing drugs known to interact with warfarin .",
        "entities": [
            "cerebral haemorrhages"
        ]
    },
    {
        "id": "580",
        "type": "disease",
        "text": "A marker of acute podocyte injury .",
        "entities": []
    },
    {
        "id": "782",
        "type": "disease",
        "text": "CONCLUSION : The addition of thalidomide to docetaxel in the treatment of prostate cancer significantly increases the frequency of VTE .",
        "entities": [
            "prostate cancer",
            "VTE"
        ]
    },
    {
        "id": "1293",
        "type": "disease",
        "text": "Initial testing in a time - dependent forgetting task employing a 24 - h delay between training and testing showed that metrifonate improved object recognition ( at 10 and 30 mg / kg , p . o . ) , whereas Ro4368554 was inactive .",
        "entities": []
    },
    {
        "id": "819",
        "type": "disease",
        "text": "Our objective was to investigate brain MR imaging findings and the utility of diffusion - weighted ( DW ) imaging in organ transplant patients who developed neurologic symptoms during tacrolimus therapy .",
        "entities": []
    },
    {
        "id": "3774",
        "type": "disease",
        "text": "Abnormal movements and deafness occurred only in rats treated during the preweaning period ; within this period the greatest sensitivities for these abnormalities occurred from 2 to 11 - 17 and 5 to 11 days of age , respectively , indicating that the cochlea is more sensitive to streptomycin than the site ( vestibular or central ) responsible for the dyskinesias .",
        "entities": [
            "Abnormal movements",
            "deafness",
            "dyskinesias"
        ]
    },
    {
        "id": "873",
        "type": "disease",
        "text": "This CAB - induced anemia was normochromic and normocytic .",
        "entities": [
            "anemia"
        ]
    },
    {
        "id": "3751",
        "type": "disease",
        "text": "During the SNP infusion the control animals demonstrated a progressive increase in blood pressure to 61 torr , whereas the saralasin - treated animals showed no change .",
        "entities": [
            "increase in blood pressure"
        ]
    },
    {
        "id": "3448",
        "type": "disease",
        "text": "Since it takes three to 12 months to achieve maximal effects , those patients who are unable to continue the drug receive little benefit from it .",
        "entities": []
    },
    {
        "id": "4050",
        "type": "disease",
        "text": "Phase II trial of vinorelbine in metastatic squamous cell esophageal carcinoma .",
        "entities": [
            "squamous cell esophageal carcinoma"
        ]
    },
    {
        "id": "4323",
        "type": "disease",
        "text": "RESULTS : Testosterone was less than 3 ng . / ml . in 107 patients but normal in 40 % at repeat determination .",
        "entities": []
    },
    {
        "id": "2534",
        "type": "disease",
        "text": "DESIGN , SETTING , AND PARTICIPANTS : Population - based , multisite , case - control study of women who had pregnancies affected by 1 of more than 30 eligible major birth defects identified via birth defect surveillance programs in 10 states ( n = 13 155 ) and control women randomly selected from the same geographical regions ( n = 4941 ) .",
        "entities": [
            "birth defects",
            "birth defect"
        ]
    },
    {
        "id": "1659",
        "type": "disease",
        "text": "In both types , purinoceptor desensitization with alpha , beta - methylene adenosine - 5 ' - triphosphate ( alpha , beta - meATP ) caused further reductions at low frequencies ( < 10 Hz ) .",
        "entities": []
    },
    {
        "id": "3128",
        "type": "disease",
        "text": "A rat model was developed to examine the effects of chronic CBZ treatment on folate concentrations in the rat .",
        "entities": []
    },
    {
        "id": "3211",
        "type": "disease",
        "text": "This paper describes the clinical features of six children who developed the haemolytic - uraemic syndrome after treatment with metronidazole .",
        "entities": [
            "haemolytic - uraemic syndrome"
        ]
    },
    {
        "id": "192",
        "type": "disease",
        "text": "This group was compared with a control group of 135 patients with ruptured aneurysms and no history of cocaine abuse .",
        "entities": [
            "ruptured aneurysms",
            "cocaine abuse"
        ]
    },
    {
        "id": "48",
        "type": "disease",
        "text": "A respiratory arrest with severe desaturation and bradycardia occurred .",
        "entities": [
            "respiratory arrest",
            "desaturation",
            "bradycardia"
        ]
    },
    {
        "id": "4440",
        "type": "disease",
        "text": "TRI given repeatedly to rats increases the locomotor hyperactivity induced by d - amphetamine , quinpirole and ( + ) - 7 - hydroxy - dipropyloaminotetralin ( dopamine D2 and D3 effects ) .",
        "entities": [
            "hyperactivity"
        ]
    },
    {
        "id": "2443",
        "type": "disease",
        "text": "This pilot study leads to the conclusion that glutamate supplementation at the chosen regimen fails to protect against peripheral neurotoxicity of PAC .",
        "entities": [
            "peripheral neurotoxicity"
        ]
    },
    {
        "id": "418",
        "type": "disease",
        "text": "The symptom was treated successfully with trihexyphenidyl anticholinergic therapy .",
        "entities": []
    },
    {
        "id": "393",
        "type": "disease",
        "text": "Conformationally restricted analogs of BD1008 and an antisense oligodeoxynucleotide targeting sigma1 receptors produce anti - cocaine effects in mice .",
        "entities": []
    },
    {
        "id": "2971",
        "type": "disease",
        "text": "Gamma - hexachlorocyclohexane ( gamma - HCH ) , the active ingredient of the insecticide lindane , has been shown to decrease seizure threshold to pentylenetrazol ( PTZ ) 3 h after exposure to gamma - HCH and conversely increase threshold to PTZ - induced seizures 24 h after exposure to gamma - HCH ( Vohland et al . 1981 ) .",
        "entities": [
            "seizure",
            "seizures"
        ]
    },
    {
        "id": "380",
        "type": "disease",
        "text": "Although such an association is of practical and theoretical importance , only one prospective study has tried to confirm it .",
        "entities": []
    },
    {
        "id": "3930",
        "type": "disease",
        "text": "Both compounds caused deformations and lethality in a dose - dependent manner .",
        "entities": [
            "deformations"
        ]
    },
    {
        "id": "732",
        "type": "disease",
        "text": "Evaluation of cardiac troponin I and T levels as markers of myocardial damage in doxorubicin - induced cardiomyopathy rats , and their relationship with echocardiographic and histological findings .",
        "entities": [
            "myocardial damage",
            "cardiomyopathy"
        ]
    },
    {
        "id": "306",
        "type": "disease",
        "text": "METHODS : We present the first case report of a woman with hyperthyroidism treated with propylthiouracil in whom a syndrome of pericarditis , fever , and glomerulonephritis developed .",
        "entities": [
            "hyperthyroidism",
            "pericarditis",
            "fever",
            "glomerulonephritis"
        ]
    },
    {
        "id": "1383",
        "type": "disease",
        "text": "The observed drug - induced effects were not due to changes in the baseline fMRI signal .",
        "entities": []
    },
    {
        "id": "3089",
        "type": "disease",
        "text": "The nephrotoxic potential of amphotericin B ( 5 mg / kg per day intraperitoneally for 3 weeks ) has been investigated in salt - depleted , normal - salt , and salt - loaded rats .",
        "entities": [
            "nephrotoxic"
        ]
    },
    {
        "id": "101",
        "type": "disease",
        "text": "High doses of the vitamin K antagonist Warfarin are also known to cause calcification of the artery media , but at treatment times of 2 weeks or longer yet not at 1 week .",
        "entities": [
            "calcification of the artery"
        ]
    },
    {
        "id": "2259",
        "type": "disease",
        "text": "Plasma aldosterone levels increased in nephrotic mice of both genotypes and was followed by increased SGK1 protein expression in sgk1 ( + / + ) mice .",
        "entities": [
            "nephrotic"
        ]
    },
    {
        "id": "1730",
        "type": "disease",
        "text": "TR ( - ) rats exhibited a significant up - regulation of Pgp in brain capillary endothelial cells compared with wild - type controls .",
        "entities": []
    },
    {
        "id": "2489",
        "type": "disease",
        "text": "However , the observation that antagonists of the glutamate N - methyl - D - aspartate ( NMDA ) receptor produce schizophrenic - like symptoms in humans has led to the idea of a dysfunctioning of the glutamatergic system via its NMDA receptor .",
        "entities": [
            "schizophrenic"
        ]
    },
    {
        "id": "2465",
        "type": "disease",
        "text": "The purpose of this report is to describe two cases of a disulfiram - like syndrome following occupational exposure to hydrogen cyanamide .",
        "entities": []
    },
    {
        "id": "4031",
        "type": "disease",
        "text": "They should be closely observed and should be given reduced doses of cimetidine .",
        "entities": []
    },
    {
        "id": "806",
        "type": "disease",
        "text": "A significant up - regulation of alphaENaC and betaENaC mRNA abundance on days 1 and 2 preceded sodium retention on days 2 and 3 .",
        "entities": []
    },
    {
        "id": "3358",
        "type": "disease",
        "text": "In previous experiments we found that decreases in food intake were induced by local administration of calcitonin into several hypothalamic sites and into the nucleus accumbens .",
        "entities": []
    },
    {
        "id": "2134",
        "type": "disease",
        "text": "Two groups were compared in this study .",
        "entities": []
    },
    {
        "id": "1226",
        "type": "disease",
        "text": "The incidence of pseudolithiasis is not affected by fasting .",
        "entities": [
            "pseudolithiasis"
        ]
    },
    {
        "id": "2658",
        "type": "disease",
        "text": "In 44 ( 62 . 8 % ) patients , ATT was prescribed empirically without definitive evidence of tuberculosis .",
        "entities": [
            "tuberculosis"
        ]
    },
    {
        "id": "3651",
        "type": "disease",
        "text": "The co - administration of aspirin with N - [ 4 - ( 5 - nitro - 2 - furyl ) - 2 - thiazolyl ] - formamide ( FANFT ) to rats resulted in a reduced incidence of FANFT - induced bladder carcinomas but a concomitant induction of forestomach tumors .",
        "entities": [
            "bladder carcinomas",
            "forestomach tumors"
        ]
    },
    {
        "id": "3547",
        "type": "disease",
        "text": "Vitamin D3 toxicity in dairy cows .",
        "entities": [
            "toxicity"
        ]
    },
    {
        "id": "2267",
        "type": "disease",
        "text": "The patient progressively developed petechiae and purpura on thorax and lower limbs .",
        "entities": [
            "petechiae",
            "purpura"
        ]
    },
    {
        "id": "162",
        "type": "disease",
        "text": "Therefore , in the present experiment , the effects of clonidine administration ( 0 . 5 mg / kg ) on cardiac rate and ultrasound production were examined in 2 - , 8 - , 15 - , and 20 - day - old rats .",
        "entities": []
    },
    {
        "id": "2264",
        "type": "disease",
        "text": "Haematological adverse reactions associated with fatal outcome are rare during treatment with ciprofloxacin .",
        "entities": []
    },
    {
        "id": "1030",
        "type": "disease",
        "text": "Such organophosphorus ( OP ) compounds as diisopropylfluorophosphate ( DFP ) , sarin and soman are potent inhibitors of acetylcholinesterases ( AChEs ) and butyrylcholinesterases ( BChEs ) .",
        "entities": []
    },
    {
        "id": "183",
        "type": "disease",
        "text": "Development of apomorphine - induced aggressive behavior : comparison of adult male and female Wistar rats .",
        "entities": [
            "aggressive behavior"
        ]
    },
    {
        "id": "202",
        "type": "disease",
        "text": "BACKGROUND AND PURPOSE : The Intravenous Nimodipine West European Stroke Trial ( INWEST ) found a correlation between nimodipine - induced reduction in blood pressure ( BP ) and an unfavorable outcome in acute stroke .",
        "entities": [
            "Stroke",
            "reduction in blood pressure",
            "acute stroke"
        ]
    },
    {
        "id": "1249",
        "type": "disease",
        "text": "Unlike general toxicity data , their prenatal toxic effects were not extensively studied before .",
        "entities": [
            "toxicity"
        ]
    },
    {
        "id": "311",
        "type": "disease",
        "text": "A literature review revealed no prior reports of pericarditis in anti - MPO pANCA - positive vasculitis associated with propylthio - uracil therapy .",
        "entities": [
            "pericarditis",
            "vasculitis"
        ]
    },
    {
        "id": "1186",
        "type": "disease",
        "text": "After 12 weeks , rats were sacrificed and their kidneys harvested .",
        "entities": []
    },
    {
        "id": "2789",
        "type": "disease",
        "text": "Thirty - two healthy young volunteers were randomly allocated to four different groups .",
        "entities": []
    },
    {
        "id": "1732",
        "type": "disease",
        "text": "A comparable overexpression of Pgp in the BBB was obtained after pilocarpine - induced seizures in wild - type Wistar rats .",
        "entities": [
            "seizures"
        ]
    },
    {
        "id": "902",
        "type": "disease",
        "text": "All of these positive GABA ( A ) modulators suppressed the expression of kindled seizures , whereas only allopregnanolone and ganaxolone inhibited the development of kindling .",
        "entities": [
            "seizures"
        ]
    },
    {
        "id": "2538",
        "type": "disease",
        "text": "Sulfonamides were associated with anencephaly ( adjusted OR [ AOR ] = 3 . 4 ; 95 % confidence interval [ CI ] , 1 . 3 - 8 . 8 ) , hypoplastic left heart syndrome ( AOR = 3 . 2 ; 95 % CI , 1 . 3 - 7 . 6 ) , coarctation of the aorta ( AOR = 2 . 7 ; 95 % CI , 1 . 3 - 5 . 6 ) , choanal atresia ( AOR = 8 . 0 ; 95 % CI , 2 . 7 - 23 . 5 ) , transverse limb deficiency ( AOR = 2 . 5 ; 95 % CI , 1 . 0 - 5 . 9 ) , and diaphragmatic hernia ( AOR = 2 . 4 ; 95 % CI , 1 . 1 - 5 . 4 ) .",
        "entities": [
            "anencephaly",
            "hypoplastic left heart syndrome",
            "coarctation of the aorta",
            "choanal atresia",
            "transverse limb deficiency",
            "diaphragmatic hernia"
        ]
    },
    {
        "id": "2880",
        "type": "disease",
        "text": "The effect of mazindol on GH secretion was estimated indirectly by comparing the postabsorptive IGF - I levels obtained following 3 , 6 , 9 , and 12 months in the mazindol treated to those in the placebo groups .",
        "entities": []
    },
    {
        "id": "3525",
        "type": "disease",
        "text": "One patient had thrombotic thrombocytopenic purpura , three the hemolytic - uremic syndrome , and one an apparent forme fruste of one of these disorders .",
        "entities": [
            "thrombotic thrombocytopenic purpura",
            "hemolytic - uremic syndrome"
        ]
    },
    {
        "id": "685",
        "type": "disease",
        "text": "RESULTS : He was treated with intravenous administration of corticosteroids and glycerin for 6 days after the injection .",
        "entities": []
    },
    {
        "id": "4508",
        "type": "disease",
        "text": "Effects of acetylsalicylic acid , dipyridamole , and hydrocortisone on epinephrine - induced myocardial injury in dogs .",
        "entities": [
            "myocardial injury"
        ]
    },
    {
        "id": "1662",
        "type": "disease",
        "text": "In inflamed preparations , the muscarinic receptor antagonism on the phasic component of the electrical field stimulation - evoked contraction was decreased and the pirenzepine and 4 - DAMP antagonism on the tonic component was much less efficient than in controls .",
        "entities": []
    },
    {
        "id": "964",
        "type": "disease",
        "text": "Levodopa - induced dyskinesias ( LIDs ) present a major problem for the long - term management of Parkinson ' s disease ( PD ) patients .",
        "entities": [
            "dyskinesias",
            "LIDs",
            "Parkinson ' s disease",
            "PD"
        ]
    },
    {
        "id": "2408",
        "type": "disease",
        "text": "In 7 of the 28 patients there was a striking temporal association between the initiation of sirolimus and the development of nephrotic - range proteinuria .",
        "entities": [
            "nephrotic",
            "proteinuria"
        ]
    },
    {
        "id": "2247",
        "type": "disease",
        "text": "A 61 - year - old Japanese man with nephrotic syndrome due to focal segmental glomerulosclerosis was initially responding well to steroid therapy .",
        "entities": [
            "nephrotic syndrome",
            "focal segmental glomerulosclerosis"
        ]
    },
    {
        "id": "794",
        "type": "disease",
        "text": "CONCLUSIONS : Cholestatic hepatitis is a rare adverse effect of ticlopidine that may be immune mediated .",
        "entities": [
            "Cholestatic hepatitis"
        ]
    },
    {
        "id": "1377",
        "type": "disease",
        "text": "Secondary hyperalgesia shares clinical characteristics with neurogenic hyperalgesia in patients with neuropathic pain .",
        "entities": [
            "Secondary hyperalgesia",
            "neurogenic hyperalgesia",
            "neuropathic pain"
        ]
    },
    {
        "id": "3528",
        "type": "disease",
        "text": "Diagnosis of this potentially fatal complication may be delayed or missed if renal tissue or the peripheral blood smear is not examined , because renal failure may be ascribed to cisplatin nephrotoxicity and the anemia and thrombocytopenia to drug - induced bone marrow suppression .",
        "entities": [
            "renal failure",
            "nephrotoxicity",
            "anemia",
            "thrombocytopenia",
            "bone marrow suppression"
        ]
    },
    {
        "id": "2656",
        "type": "disease",
        "text": "From January 1986 to January 2009 , 1223 consecutive ALF patients were evaluated : ATT alone was the cause in 70 ( 5 . 7 % ) patients .",
        "entities": [
            "ALF"
        ]
    },
    {
        "id": "2859",
        "type": "disease",
        "text": "Ocular and auditory toxicity in hemodialyzed patients receiving desferrioxamine .",
        "entities": [
            "Ocular and auditory toxicity"
        ]
    },
    {
        "id": "2151",
        "type": "disease",
        "text": "Symptoms persisted for three months despite TAC dose reduction , administration of IVIG and four doses of methylprednisolone pulse therapy .",
        "entities": []
    },
    {
        "id": "440",
        "type": "disease",
        "text": "The girl died seven days , the man four weeks after intrathecal injection of vincristine .",
        "entities": []
    },
    {
        "id": "2429",
        "type": "disease",
        "text": "Isoproterenol - treated rats showed significant increases in the levels of lactate dehydrogenase , aspartate transaminase , creatine kinase and malondialdehyde and significant decreases in the activities of superoxide dismutase , catalase and glutathione peroxidase in serum and heart .",
        "entities": []
    },
    {
        "id": "2681",
        "type": "disease",
        "text": "This study analyzed the incidence of neurological complications during ALL treatment in a single pediatric institution , focusing on clinical , radiological , and electrophysiological findings .",
        "entities": [
            "neurological complications",
            "ALL"
        ]
    },
    {
        "id": "27",
        "type": "disease",
        "text": "Cocaine - induced mood disorder : prevalence rates and psychiatric symptoms in an outpatient cocaine - dependent sample .",
        "entities": [
            "mood disorder",
            "psychiatric"
        ]
    },
    {
        "id": "2845",
        "type": "disease",
        "text": "A Phase I study of intravenous ( IV ) bolus 4 ' - 0 - tetrahydropyranyladriamycin ( Pirarubicin ) was done in 55 patients in good performance status with refractory tumors .",
        "entities": [
            "tumors"
        ]
    },
    {
        "id": "1895",
        "type": "disease",
        "text": "CONCLUSION : Here we report a case of acute hepatitis probably associated with the administration of telithromycin .",
        "entities": [
            "hepatitis"
        ]
    },
    {
        "id": "3546",
        "type": "disease",
        "text": "After re - infarction , heart size increased in the placebo group and remained unchanged in the timolol group .",
        "entities": [
            "infarction"
        ]
    },
    {
        "id": "3221",
        "type": "disease",
        "text": "During treatment , adverse cardiac effects were observed in 14 patients ( 18 % ) .",
        "entities": []
    },
    {
        "id": "2322",
        "type": "disease",
        "text": "Prophylactic administration of lamivudine in patients who required immunosuppressive therapy seems to be safe , well tolerated and effective in preventing HBV reactivation .",
        "entities": []
    },
    {
        "id": "1598",
        "type": "disease",
        "text": "Further long - term analysis of renal allograft studies using sirolimus as de novo immunosuppression along with clinical and laboratory studies will refine these issues in the future .",
        "entities": []
    },
    {
        "id": "1495",
        "type": "disease",
        "text": "RESULTS : Among 593 patients with cerebral haemorrhage , 59 ( 10 % ) were assessed as related to warfarin treatment .",
        "entities": [
            "cerebral haemorrhage"
        ]
    },
    {
        "id": "426",
        "type": "disease",
        "text": "Four compounds known to increase QT interval and cause TDP were investigated : terfenadine , terodiline , cisapride and E4031 .",
        "entities": [
            "TDP"
        ]
    },
    {
        "id": "3776",
        "type": "disease",
        "text": "Cardiac toxicity is a major complication which limits the use of adriamycin as a chemotherapeutic agent .",
        "entities": [
            "Cardiac toxicity"
        ]
    },
    {
        "id": "4261",
        "type": "disease",
        "text": "Haemodilution in groups B and C was produced by withdrawing approximately 1000 mL of blood and replacing it with the same amount of dextran solution , and final haematocrit values were 21 or 22 % .",
        "entities": [
            "Haemodilution"
        ]
    },
    {
        "id": "3810",
        "type": "disease",
        "text": "The [ verapamil ] o that arrested atrial beating ( AC ) was also potentiated with the order LNa = LNa + LCa = LNa + HCa = LCa > HCa = N .",
        "entities": []
    },
    {
        "id": "1815",
        "type": "disease",
        "text": "In this study , we examined the roles of lipopolysaccharide , a pro - inflammatory and inflammatory factor , treatment in modulating the methamphetamine - induced nigrostriatal dopamine neurotoxicity .",
        "entities": [
            "neurotoxicity"
        ]
    },
    {
        "id": "991",
        "type": "disease",
        "text": "In addition , both change and peak , showed significant positive correlations with migraine headache intensity ( P < 0 . 001 ) .",
        "entities": [
            "headache"
        ]
    },
    {
        "id": "4313",
        "type": "disease",
        "text": "Such patients should be under close follow - up , preferably with periodic ultrasound examination of the liver .",
        "entities": []
    },
    {
        "id": "2135",
        "type": "disease",
        "text": "The prophylactic lamivudin group consisted of 37 patients who received prophylactic lamivudine treatment .",
        "entities": []
    },
    {
        "id": "2612",
        "type": "disease",
        "text": "Compared with placebo , modafinil decreased nighttime sleep latency and increased slow - wave sleep time in cocaine - dependent participants .",
        "entities": []
    },
    {
        "id": "3667",
        "type": "disease",
        "text": "In the nine responders , median duration of chemotherapy response from the time of operation was 25 weeks ( range 12 to more than 91 weeks ) .",
        "entities": []
    },
    {
        "id": "2632",
        "type": "disease",
        "text": "There were no severe events and there was no need to interrupt the examinations .",
        "entities": []
    },
    {
        "id": "3565",
        "type": "disease",
        "text": "Some of the factors related to the clinical presentation and pathogenesis of the neuropathies are briefly discussed .",
        "entities": [
            "neuropathies"
        ]
    },
    {
        "id": "1530",
        "type": "disease",
        "text": "She was unable to urinate .",
        "entities": []
    },
    {
        "id": "4107",
        "type": "disease",
        "text": "The overall response rate is 72 % .",
        "entities": []
    },
    {
        "id": "2083",
        "type": "disease",
        "text": "The bronchodilator effects of a single dose of ipratropium bromide aerosol ( 36 micrograms ) and short - acting theophylline tablets ( dose titrated to produce serum levels of 10 - 20 micrograms / mL ) were compared in a double - blind , placebo - controlled crossover study in 21 patients with stable , chronic obstructive pulmonary disease .",
        "entities": [
            "chronic obstructive pulmonary disease"
        ]
    },
    {
        "id": "245",
        "type": "disease",
        "text": "Patients who are switched from cyclosporine to tacrolimus or vice versa should be closely monitored for the signs and symptoms of recurrent TMA .",
        "entities": [
            "TMA"
        ]
    },
    {
        "id": "3662",
        "type": "disease",
        "text": "Intra - arterial BCNU chemotherapy for treatment of malignant gliomas of the central nervous system .",
        "entities": [
            "malignant gliomas"
        ]
    },
    {
        "id": "4471",
        "type": "disease",
        "text": "Five patients died before the interview , all of them had taken appetite suppressants .",
        "entities": []
    },
    {
        "id": "2218",
        "type": "disease",
        "text": "This study supports previous reports and provides neurophysiological evidence of an adverse effect on the auditory nerve .",
        "entities": []
    },
    {
        "id": "3251",
        "type": "disease",
        "text": "The systemic , central venous , pulmonary capillary wedge pressures , and heart rates , were similar in the two groups .",
        "entities": []
    },
    {
        "id": "1083",
        "type": "disease",
        "text": "Cardioprotective effect of tincture of Crataegus on isoproterenol - induced myocardial infarction in rats .",
        "entities": [
            "myocardial infarction"
        ]
    },
    {
        "id": "1122",
        "type": "disease",
        "text": "STUDY DESIGN : We combined paclitaxel , melphalan and high - dose cyclophosphamide , thiotepa , and carboplatin in a triple sequential high - dose regimen for patients with metastatic breast cancer .",
        "entities": [
            "breast cancer"
        ]
    },
    {
        "id": "3684",
        "type": "disease",
        "text": "Pituitary tumors were induced in F344 female rats by chronic treatment with diethylstilbestrol ( DES , 8 - 10 mg ) implanted subcutaneously in silastic capsules .",
        "entities": [
            "Pituitary tumors"
        ]
    },
    {
        "id": "4105",
        "type": "disease",
        "text": "Of 18 patients evaluable for response , seven ( 39 % ) achieved a complete response and six ( 33 % ) achieved a partial response .",
        "entities": []
    },
    {
        "id": "1227",
        "type": "disease",
        "text": "Coronary aneurysm after implantation of a paclitaxel - eluting stent .",
        "entities": [
            "Coronary aneurysm"
        ]
    },
    {
        "id": "207",
        "type": "disease",
        "text": "Nimodipine treatment resulted in a statistically significant reduction in systolic BP ( SBP ) and diastolic BP ( DBP ) from baseline compared with placebo during the first few days .",
        "entities": [
            "reduction in systolic BP"
        ]
    },
    {
        "id": "2257",
        "type": "disease",
        "text": "To this end , doxorubicin ( 15 mug / g body wt ) was injected intravenously into gene - targeted mice lacking SGK1 ( sgk1 ( - / - ) ) and their wild - type littermates ( sgk1 ( + / + ) ) .",
        "entities": []
    },
    {
        "id": "4101",
        "type": "disease",
        "text": "Treatment , given every 21 days for a maximum of three cycles , consisted of paclitaxel by 3 - hour infusion followed the next day by a fixed dose of cisplatin ( 75 mg / m2 ) .",
        "entities": []
    },
    {
        "id": "4144",
        "type": "disease",
        "text": "Number and total anionic site surface in the remaining part of the glomerular basement membrane ( lamina densa and lamina rara interna ) were not significantly changed .",
        "entities": []
    },
    {
        "id": "4467",
        "type": "disease",
        "text": "The importance of this association was evaluated in Belgium while this country still had no restriction on the prescription of appetite suppressants .",
        "entities": []
    },
    {
        "id": "2068",
        "type": "disease",
        "text": "Pretreatment with the D2 agonist PHNO enhanced nicotine - induced hyperactivity , whereas the D1 agonist SKF 38393 had no effect .",
        "entities": [
            "hyperactivity"
        ]
    },
    {
        "id": "436",
        "type": "disease",
        "text": "Various reported side effects of fentanyl administration include chest wall rigidity , hypotension , respiratory depression , and bradycardia .",
        "entities": [
            "chest wall rigidity",
            "hypotension",
            "respiratory depression",
            "bradycardia"
        ]
    },
    {
        "id": "3215",
        "type": "disease",
        "text": "Survival for patients with advanced head and neck carcinoma and esophageal carcinoma is poor with radiotherapy and / or surgery .",
        "entities": [
            "head and neck carcinoma",
            "esophageal carcinoma"
        ]
    },
    {
        "id": "2004",
        "type": "disease",
        "text": "OBJECTIVES : To correlate optical density and percent inhibition of a two - step heparin - induced thrombocytopenia ( HIT ) antigen assay with thrombosis ; the assay utilizes reaction inhibition characteristics of a high heparin concentration .",
        "entities": [
            "thrombocytopenia",
            "HIT",
            "thrombosis"
        ]
    },
    {
        "id": "3205",
        "type": "disease",
        "text": "Verapamil withdrawal as a possible cause of myocardial infarction in a hypertensive woman with a normal coronary angiogram .",
        "entities": [
            "myocardial infarction",
            "hypertensive"
        ]
    },
    {
        "id": "1034",
        "type": "disease",
        "text": "The control rats received atropine sulfate , but also saline and olive oil instead of other antidotes and DFP , respectively .",
        "entities": []
    },
    {
        "id": "3766",
        "type": "disease",
        "text": "A possible involvement of energy metabolism was suggested previously , and in this study the adenylate energy charge and phosphorylcreatine mole fraction were determined in the adriamycin - treated cells .",
        "entities": []
    },
    {
        "id": "2156",
        "type": "disease",
        "text": "METHODS : This double - blind study examined the incidence and severity of postoperative nausea and vomiting and pain in the first 24 h after sevoflurane anaesthesia in 216 adult day surgery patients .",
        "entities": [
            "postoperative nausea and vomiting",
            "pain"
        ]
    },
    {
        "id": "256",
        "type": "disease",
        "text": "A significant difference in MMSE was observed at T30 in patients who received 0 . 50 mg / kg of ketamine .",
        "entities": []
    },
    {
        "id": "1647",
        "type": "disease",
        "text": "Three hundred fifty - five adult male CSS mice , 58 B6 , and 39 A / J were tested for susceptibility to pilocarpine - induced seizures .",
        "entities": [
            "seizures"
        ]
    },
    {
        "id": "2780",
        "type": "disease",
        "text": "Future research with larger number of patients is needed to find out modifiable factors that will improve the safety of ribavirin therapy .",
        "entities": []
    },
    {
        "id": "3988",
        "type": "disease",
        "text": "Neuroplasticity of the adult primate auditory cortex following cochlear hearing loss .",
        "entities": [
            "hearing loss"
        ]
    },
    {
        "id": "829",
        "type": "disease",
        "text": "We investigate whether abnormalities in L - arginine uptake contribute to this deficiency .",
        "entities": []
    },
    {
        "id": "3593",
        "type": "disease",
        "text": "Bradycardia ( defined as a decrease in heart rate to less than 50 beat min - 1 ) was prevented when the larger dose of either active drug was used .",
        "entities": [
            "Bradycardia"
        ]
    },
    {
        "id": "4316",
        "type": "disease",
        "text": "PURPOSE : We reviewed the results of serum testosterone and prolactin determination in 1 , 022 patients referred because of erectile dysfunction and compared the data with history , results of physical examination , other etiological investigations and effects of endocrine therapy to refine the rules of cost - effective endocrine screening and to pinpoint actual responsibility for hormonal abnormalities .",
        "entities": [
            "erectile dysfunction"
        ]
    },
    {
        "id": "3618",
        "type": "disease",
        "text": "Light microscopic analysis showed a significant protection against ADR - induced cardiac morphological alterations .",
        "entities": [
            "cardiac morphological alterations"
        ]
    },
    {
        "id": "137",
        "type": "disease",
        "text": "Inhibition of NO synthesis induces sustained hypertension .",
        "entities": [
            "hypertension"
        ]
    },
    {
        "id": "3756",
        "type": "disease",
        "text": "A prospective study .",
        "entities": []
    },
    {
        "id": "260",
        "type": "disease",
        "text": "Paclitaxel , cisplatin , and gemcitabine combination chemotherapy within a multidisciplinary therapeutic approach in metastatic nonsmall cell lung carcinoma .",
        "entities": [
            "nonsmall cell lung carcinoma"
        ]
    },
    {
        "id": "706",
        "type": "disease",
        "text": "The possibility of drug - induced aggravation should be considered whenever an unexpected increase in seizure frequency and / or new seizure types appear following a change in drug treatment .",
        "entities": [
            "seizure",
            "seizure"
        ]
    },
    {
        "id": "858",
        "type": "disease",
        "text": "Pseudoacromegaly induced by the long - term use of minoxidil .",
        "entities": [
            "Pseudoacromegaly"
        ]
    },
    {
        "id": "1807",
        "type": "disease",
        "text": "In the present study , we investigated whether maltolyl p - coumarate could improve cognitive decline in scopolamine - injected rats and in amyloid beta peptide ( 1 - 42 ) - infused rats .",
        "entities": [
            "cognitive decline"
        ]
    },
    {
        "id": "466",
        "type": "disease",
        "text": "In the bolus group , 26 . 0 % ( 13 / 50 ) had akathisia compared with 32 . 7 % ( 16 / 49 ) in the infusion group ( Delta = - 6 . 7 % ; 95 % confidence interval [ CI ] - 24 . 6 % to 11 . 2 % ) .",
        "entities": [
            "akathisia"
        ]
    },
    {
        "id": "4382",
        "type": "disease",
        "text": "The antinociceptive effect of 3 alpha - tropyl 2 - ( p - bromophenyl ) propionate [ ( + / - ) - PG - 9 ] ( 10 - 40 mg kg - 1 s . c . ; 30 - 60 mg kg - 1 p . o . ; 10 - 30 mg kg - 1 i . v . ; 10 - 30 micrograms / mouse i . c . v . ) was examined in mice , rats and guinea pigs by use of the hot - plate , abdominal - constriction , tail - flick and paw - pressure tests .",
        "entities": []
    },
    {
        "id": "896",
        "type": "disease",
        "text": "Protective efficacy of neuroactive steroids against cocaine kindled - seizures in mice .",
        "entities": [
            "seizures"
        ]
    },
    {
        "id": "2016",
        "type": "disease",
        "text": "Thalidomide is an immunomodulatory agent with demonstrated activity in multiple myeloma , mantle cell lymphoma and lymphoplasmacytic lymphoma .",
        "entities": [
            "multiple myeloma",
            "mantle cell lymphoma",
            "lymphoplasmacytic lymphoma"
        ]
    },
    {
        "id": "3809",
        "type": "disease",
        "text": "Independent but not additive effects of Na and Ca are shown by decreases in the values of [ verapamil ] o needed to reduce BF by 30 % ( IC30 ) with the following order of inhibitory potency : LNa > LCa > HCa > N , resulting LNa + HCa similar to LNa .",
        "entities": []
    },
    {
        "id": "1980",
        "type": "disease",
        "text": "Clonidine for attention - deficit / hyperactivity disorder : II .",
        "entities": [
            "attention - deficit / hyperactivity disorder"
        ]
    },
    {
        "id": "528",
        "type": "disease",
        "text": "The development of ESRD decreases survival , particularly in those patients treated with dialysis only .",
        "entities": [
            "ESRD"
        ]
    },
    {
        "id": "412",
        "type": "disease",
        "text": "This report presents the clinical , laboratory , and light and electron microscopic observations on a patient with chronic active ( aggressive ) hepatitis caused by the administration of propylthiouracil .",
        "entities": [
            "chronic active ( aggressive ) hepatitis"
        ]
    },
    {
        "id": "773",
        "type": "disease",
        "text": "Further work is warranted on the effect of the treatments on renal functional aspects in models of chronic renal failure , and on the mechanism ( s ) involved .",
        "entities": [
            "chronic renal failure"
        ]
    },
    {
        "id": "1754",
        "type": "disease",
        "text": "PURPOSE : To assess the incidence of postoperative emetic side effects after the administration of methylprednisolone and gentamicin into the posterior sub - Tenon ' s space at the end of routine cataract surgery .",
        "entities": [
            "cataract"
        ]
    },
    {
        "id": "2510",
        "type": "disease",
        "text": "Anaesthetists ' nightmare : masseter spasm after induction in an undiagnosed case of myotonia congenita .",
        "entities": [
            "masseter spasm",
            "myotonia congenita"
        ]
    },
    {
        "id": "3900",
        "type": "disease",
        "text": "Plasma PRL concentrations were analysed at 10 min intervals and underlying secretory rates calculated by a deconvolution procedure .",
        "entities": []
    },
    {
        "id": "624",
        "type": "disease",
        "text": "BACKGROUND : The septo - hippocampal cholinergic pathway has been implicated in epileptogenesis , and genetic factors influence the response to cholinergic agents , but limited data are available on cholinergic involvement in alcohol withdrawal severity .",
        "entities": []
    },
    {
        "id": "3369",
        "type": "disease",
        "text": "We conclude that the administration of high doses of cefonicid or cefazedone to dogs can induce hematotoxicity similar to the cephalosporin - induced blood dyscrasias described in man and thus provides a useful model for studying the mechanisms of these disorders .",
        "entities": [
            "hematotoxicity",
            "blood dyscrasias"
        ]
    },
    {
        "id": "2308",
        "type": "disease",
        "text": "The management options in the ED , as exemplified by four individual case reports , in particular the use of a minimally invasive method of intracorporal epinephrine instillation , are discussed .",
        "entities": []
    },
    {
        "id": "88",
        "type": "disease",
        "text": "NRA0160 and clozapine significantly shortened the phencyclidine ( PCP ) - induced prolonged swimming latency in rats in a water maze task .",
        "entities": []
    },
    {
        "id": "1183",
        "type": "disease",
        "text": "METHODS : Renal ACE activity ( Hip - His - Leu cleavage by cortical homogenates ) was determined by renal biopsy in 27 adult male Wistar rats .",
        "entities": []
    },
    {
        "id": "4162",
        "type": "disease",
        "text": "Effect of some anticancer drugs and combined chemotherapy on renal toxicity .",
        "entities": [
            "renal toxicity"
        ]
    },
    {
        "id": "2546",
        "type": "disease",
        "text": "We therefore systematically analyzed the functional impact of the most prevalent immune escape variants , the sG145R and sP120T mutants , on the viral replication efficacy and antiviral drug susceptibility of common treatment - associated mutants with resistance to lamivudine ( LAM ) and / or HBeAg negativity .",
        "entities": []
    },
    {
        "id": "2072",
        "type": "disease",
        "text": "OBJECTIVE : To report a case of central retinal vein occlusion associated with clomiphene citrate ( CC ) .",
        "entities": [
            "retinal vein occlusion"
        ]
    },
    {
        "id": "2999",
        "type": "disease",
        "text": "Readministration of amantadine , after a drug - free overnight period , increased motility from respective saline control in all strains with exception of the BALB / C mice where suppression of motility occurred .",
        "entities": [
            "suppression of motility"
        ]
    },
    {
        "id": "442",
        "type": "disease",
        "text": "Histological and immunohistochemical investigations ( HE - LFB , CD - 68 , Neurofilament ) revealed degeneration of myelin and axons as well as pseudocystic transformation in areas exposed to vincristine , accompanied by secondary changes with numerous prominent macrophages .",
        "entities": [
            "degeneration of myelin and axons",
            "pseudocystic transformation"
        ]
    },
    {
        "id": "1216",
        "type": "disease",
        "text": "Importantly , a decrease in glutamate uptake correlates negatively with an increase in the incidence of orofacial diskinesia .",
        "entities": [
            "orofacial diskinesia"
        ]
    },
    {
        "id": "1674",
        "type": "disease",
        "text": "Clonidine inhibited the native pacemaker current ( I ( f ) ) in isolated sinoatrial node pacemaker cells and the I ( f ) - generating hyperpolarization - activated cyclic nucleotide - gated ( HCN ) 2 and HCN4 channels in transfected HEK293 cells .",
        "entities": []
    },
    {
        "id": "235",
        "type": "disease",
        "text": "Cyclosporine and tacrolimus - associated thrombotic microangiopathy .",
        "entities": [
            "thrombotic microangiopathy"
        ]
    },
    {
        "id": "3765",
        "type": "disease",
        "text": "Adriamycin inhibited cell growth and the rhythmic contractions characteristic of myocardial cells in culture .",
        "entities": []
    },
    {
        "id": "3590",
        "type": "disease",
        "text": "The effectiveness of administration of glycopyrrolate 5 and 10 micrograms kg - 1 and atropine 10 and 20 micrograms kg - 1 i . v . immediately before the induction of anaesthesia , to prevent arrhythmia and bradycardia following repeated doses of suxamethonium in children , was studied .",
        "entities": [
            "arrhythmia",
            "bradycardia"
        ]
    },
    {
        "id": "2576",
        "type": "disease",
        "text": "STUDY DESIGN AND METHODS : Plasma samples from before and after CPB were analyzed postoperatively for argatroban concentration using a modified ecarin clotting time ( ECT ) assay .",
        "entities": []
    },
    {
        "id": "2535",
        "type": "disease",
        "text": "MAIN EXPOSURE : Reported maternal use of antibacterials ( 1 month before pregnancy through the end of the first trimester ) .",
        "entities": []
    },
    {
        "id": "3230",
        "type": "disease",
        "text": "The multiple drug schema consisted of : Etoposide 16 . 213 , Methotrexate , Cyclophosphamide , Actomycin - D , and Cisplatin .",
        "entities": []
    },
    {
        "id": "4397",
        "type": "disease",
        "text": "Long - term follow - up of the patients was not possible .",
        "entities": []
    },
    {
        "id": "2559",
        "type": "disease",
        "text": "Two weeks after the initiation of therapy , her hematocrit had decreased from 44 . 1 % to 20 . 4 % , and she had a positive direct Coombs antiglobulin test and an elevated indirect bilirubin .",
        "entities": []
    },
    {
        "id": "745",
        "type": "disease",
        "text": "Only five of the controls exhibited evidence of very slight perivascular fibrosis .",
        "entities": [
            "fibrosis"
        ]
    },
    {
        "id": "3038",
        "type": "disease",
        "text": "We report the case of a patient who developed acute hepatitis with extensive hepatocellular necrosis , 7 months after the onset of administration of clotiazepam , a thienodiazepine derivative .",
        "entities": [
            "hepatitis",
            "extensive hepatocellular necrosis"
        ]
    },
    {
        "id": "1278",
        "type": "disease",
        "text": "Seizures induced by the cocaine metabolite benzoylecgonine in rats .",
        "entities": [
            "Seizures"
        ]
    },
    {
        "id": "2263",
        "type": "disease",
        "text": "Severe thrombocytopenia and haemolytic anaemia associated with ciprofloxacin : a case report with fatal outcome .",
        "entities": [
            "thrombocytopenia",
            "haemolytic anaemia"
        ]
    },
    {
        "id": "3362",
        "type": "disease",
        "text": "Cephalosporin antibiotics cause a variety of hematologic disturbances in man , the pathogeneses and hematopathology of which remain poorly characterized .",
        "entities": [
            "hematologic disturbances"
        ]
    },
    {
        "id": "3789",
        "type": "disease",
        "text": "Associated corticosteroid therapy and twin gestations appear to be predisposing factors .",
        "entities": []
    },
    {
        "id": "2337",
        "type": "disease",
        "text": "Blood pressure ( BP ) is more salt sensitive in men than in premenopausal women .",
        "entities": []
    },
    {
        "id": "1885",
        "type": "disease",
        "text": "CASE SUMMARY : A 25 - year - old male patient , with a height of 175 cm and weight of 72 kg presented to Marmara University Hospital Emergency Department , Istanbul , Turkey , with 5 days ' history of jaundice , malaise , nausea , and vomiting .",
        "entities": [
            "jaundice",
            "nausea",
            "vomiting"
        ]
    },
    {
        "id": "4128",
        "type": "disease",
        "text": "Acetaminophen - induced hypotension .",
        "entities": [
            "hypotension"
        ]
    },
    {
        "id": "2043",
        "type": "disease",
        "text": "Patients without proteinuria had increased renal function ( median 42 . 5 vs . 64 . 1 , p = 0 . 25 ) , whereas patients who developed high - grade proteinuria showed decreased renal function at the end of follow - up ( median 39 . 6 vs . 29 . 2 , p = 0 . 125 ) .",
        "entities": [
            "proteinuria",
            "proteinuria"
        ]
    },
    {
        "id": "551",
        "type": "disease",
        "text": "However , in many cases , the exencephalic brain tissue was preserved with more or less reduction during this period .",
        "entities": [
            "exencephalic"
        ]
    },
    {
        "id": "510",
        "type": "disease",
        "text": "Among women who used oral contraceptives , the odds ratio was 2 . 1 ( 95 percent confidence interval , 1 . 5 to 3 . 0 ) for those without a prothrombotic mutation and 1 . 9 ( 95 percent confidence interval , 0 . 6 to 5 . 5 ) for those with a mutation CONCLUSIONS : The risk of myocardial infarction was increased among women who used second - generation oral contraceptives .",
        "entities": [
            "myocardial infarction"
        ]
    },
    {
        "id": "3350",
        "type": "disease",
        "text": "Case report .",
        "entities": []
    },
    {
        "id": "361",
        "type": "disease",
        "text": "Additionally , histopathological alterations mirrored both serum chemistry changes and the pattern of DNA fragmentation .",
        "entities": []
    },
    {
        "id": "926",
        "type": "disease",
        "text": "In this model of chronic renal failure the decline in GFR is not accompanied by a corresponding fall in effective renal plasma flow , which may be the functional expression of the formation of nonfiltrating atubular glomeruli .",
        "entities": [
            "chronic renal failure"
        ]
    },
    {
        "id": "1370",
        "type": "disease",
        "text": "The most common adverse events were nausea ( 17 . 2 % and 16 . 1 % ; 95 % CI , - 3 . 7 to 6 . 0 ) , hiccups ( 10 . 7 % and 6 . 6 % ; 95 % CI , 0 . 5 to 7 . 8 ) , and headache ( 8 . 7 % and 9 . 9 % ; 95 % Cl , - 5 . 0 to 2 . 6 ) .",
        "entities": [
            "nausea",
            "hiccups",
            "headache"
        ]
    },
    {
        "id": "3798",
        "type": "disease",
        "text": "Biological features of hepatitis disappeared in all cases after cessation of the incriminated drug , while biliary , viral and immunological searches were negative .",
        "entities": [
            "hepatitis"
        ]
    },
    {
        "id": "1016",
        "type": "disease",
        "text": "These effects gave rise to an increase in the right atrial pressure and a decrease in the left one with a consequent stretching of the foramen ovale and the creation of massive right - to - left shunting .",
        "entities": []
    },
    {
        "id": "1733",
        "type": "disease",
        "text": "Experiments with systemic administration of the Pgp substrate phenobarbital and the selective Pgp inhibitor tariquidar in TR ( - ) rats substantiated that Pgp is functional and compensates for the lack of MRP2 in the BBB .",
        "entities": []
    },
    {
        "id": "1027",
        "type": "disease",
        "text": "The blood flow responses seem to be mediated by the release of acetylcholine and VIP within the meninges .",
        "entities": []
    },
    {
        "id": "2962",
        "type": "disease",
        "text": "The incidence of preneoplastic nodules and of hepatocellular carcinomas was 10 % and 37 % , respectively , in rats fed the plain choline - devoid diet , and 17 % and 30 % , in rats fed the phenobarbital - containing choline - devoid diet .",
        "entities": [
            "hepatocellular carcinomas"
        ]
    },
    {
        "id": "4181",
        "type": "disease",
        "text": "METHOD : Open , case series design .",
        "entities": []
    },
    {
        "id": "2292",
        "type": "disease",
        "text": "Histopathology analyses in the 2 animals that died revealed liver and kidney toxicity , with greater severity in the orally - treated animal .",
        "entities": [
            "liver and kidney toxicity"
        ]
    },
    {
        "id": "1171",
        "type": "disease",
        "text": "Patients were followed for 8 - 14 years .",
        "entities": []
    },
    {
        "id": "1538",
        "type": "disease",
        "text": "METHODS : In a population - based study in 513 naturally postmenopausal women aged 54 - 67 years , we studied the association between self - reported intramuscularly administered high - dose estrogen - testosterone therapy ( estradiol - and testosterone esters ) and aortic atherosclerosis .",
        "entities": [
            "atherosclerosis"
        ]
    },
    {
        "id": "149",
        "type": "disease",
        "text": "It has been shown that bromocriptine - induced tachycardia , which persisted after adrenalectomy , is ( i ) mediated by central dopamine D2 receptor activation and ( ii ) reduced by 5 - day isoproterenol pretreatment , supporting therefore the hypothesis that this effect is dependent on sympathetic outflow to the heart .",
        "entities": [
            "tachycardia"
        ]
    },
    {
        "id": "1031",
        "type": "disease",
        "text": "The acute toxicity of OPs is the result of their irreversible binding with AChEs in the central nervous system ( CNS ) , which elevates acetylcholine ( ACh ) levels .",
        "entities": [
            "toxicity"
        ]
    },
    {
        "id": "3720",
        "type": "disease",
        "text": "Seven cases of procainamide - induced polymorphous ventricular tachycardia are presented .",
        "entities": [
            "ventricular tachycardia"
        ]
    },
    {
        "id": "2665",
        "type": "disease",
        "text": "The mortality rate among patients with ATT - ALF was high ( 67 . 1 % , n = 47 ) , and only 23 ( 32 . 9 % ) patients recovered with medical treatment .",
        "entities": [
            "ALF"
        ]
    },
    {
        "id": "523",
        "type": "disease",
        "text": "Compared with control patients , CRF and ESRD patients had higher preoperative serum creatinine levels , a greater percentage of patients with hepatorenal syndrome , higher percentage requirement for dialysis in the first 3 months postoperatively , and a higher 1 - year serum creatinine .",
        "entities": [
            "CRF",
            "ESRD",
            "hepatorenal syndrome"
        ]
    },
    {
        "id": "2864",
        "type": "disease",
        "text": "Auditory toxicity was characterized by a mid - to high - frequency neurosensorial hearing loss and the lesion was of the cochlear type .",
        "entities": [
            "Auditory toxicity",
            "neurosensorial hearing loss"
        ]
    },
    {
        "id": "3928",
        "type": "disease",
        "text": "The purpose of this study was to evaluate and compare the effects of coniine and nicotine in the developing chick .",
        "entities": []
    },
    {
        "id": "775",
        "type": "disease",
        "text": "STUDY OBJECTIVE : To evaluate the frequency of venous thromboembolism ( VTE ) in patients with advanced androgen - independent prostate cancer who were treated with docetaxel alone or in combination with thalidomide .",
        "entities": [
            "venous thromboembolism",
            "VTE",
            "prostate cancer"
        ]
    },
    {
        "id": "2543",
        "type": "disease",
        "text": "Differential impact of immune escape mutations G145R and P120T on the replication of lamivudine - resistant hepatitis B virus e antigen - positive and - negative strains .",
        "entities": []
    },
    {
        "id": "3871",
        "type": "disease",
        "text": "Kidney cortices from each animal were used to prepare homogenates .",
        "entities": []
    },
    {
        "id": "340",
        "type": "disease",
        "text": "The plasma levels of atrial natriuretic peptide ( ANP ) and BNP were measured at the time of radionuclide angiography .",
        "entities": []
    },
    {
        "id": "552",
        "type": "disease",
        "text": "To analyze the transformation patterns , we classified the exencephaly by size and shape of the exencephalic tissue into several types at E13 . 5 and E18 . 5 .",
        "entities": [
            "exencephaly",
            "exencephalic"
        ]
    },
    {
        "id": "2869",
        "type": "disease",
        "text": "Serial epilepsy caused by levodopa / carbidopa administration in two patients on hemodialysis .",
        "entities": [
            "epilepsy"
        ]
    },
    {
        "id": "4196",
        "type": "disease",
        "text": "The similarities between the effects of structural lesions and pharmacological depression of the brain stem reticular formation are discussed .",
        "entities": [
            "depression"
        ]
    },
    {
        "id": "1118",
        "type": "disease",
        "text": "It is suggested that sevoflurane reduces the convulsive effect of lidocaine toxicity but carries some risk due to circulatory depression .",
        "entities": [
            "convulsive",
            "toxicity",
            "depression"
        ]
    },
    {
        "id": "293",
        "type": "disease",
        "text": "Hypotension following the initiation of tizanidine in a patient treated with an angiotensin converting enzyme inhibitor for chronic hypertension .",
        "entities": [
            "Hypotension",
            "hypertension"
        ]
    },
    {
        "id": "687",
        "type": "disease",
        "text": "Finally , 6 weeks later , diffuse chorioretinal atrophy with optic atrophy occurred and the vision in his left eye was lost .",
        "entities": [
            "chorioretinal atrophy",
            "optic atrophy"
        ]
    },
    {
        "id": "410",
        "type": "disease",
        "text": "Allograft function improved rapidly and returned to baseline after stopping the drug .",
        "entities": []
    },
    {
        "id": "1100",
        "type": "disease",
        "text": "A gene cluster comprises the alpha3 , alpha5 and beta4 subunits , which coassemble to form functional receptors .",
        "entities": []
    },
    {
        "id": "1449",
        "type": "disease",
        "text": "We report an interesting case investigating a ( near ) fatal poisoning .",
        "entities": [
            "poisoning"
        ]
    },
    {
        "id": "3202",
        "type": "disease",
        "text": "These variables returned to baseline when rigidity was abolished with metocurine .",
        "entities": [
            "rigidity"
        ]
    },
    {
        "id": "4078",
        "type": "disease",
        "text": "This study investigated propofol injection pain in patients undergoing ambulatory anaesthesia .",
        "entities": [
            "pain"
        ]
    },
    {
        "id": "2321",
        "type": "disease",
        "text": "Lamivudine was well tolerated and was continued in all patients .",
        "entities": []
    },
    {
        "id": "837",
        "type": "disease",
        "text": "Plasma cortisol concentrations were significantly raised during the active phase ( 323 + / - 43 to 1082 + / - 245 mmol / L , P < 0 . 05 ) .",
        "entities": []
    },
    {
        "id": "2726",
        "type": "disease",
        "text": "The other proteins showed few changes , which were limited to diseased areas .",
        "entities": []
    },
    {
        "id": "3999",
        "type": "disease",
        "text": "Sodium bicarbonate alleviates penile pain induced by intracavernous injections for erectile dysfunction .",
        "entities": [
            "penile pain",
            "erectile dysfunction"
        ]
    },
    {
        "id": "979",
        "type": "disease",
        "text": "These results suggest that a diet comprised of alternating deprivation and access to a sugar solution and chow produces bingeing on sugar that leads to a long lasting state of increased sensitivity to amphetamine , possibly due to a lasting alteration in the dopamine system .",
        "entities": []
    },
    {
        "id": "1133",
        "type": "disease",
        "text": "Aim of the study was to determine sensitivity , reproducibility , reference values and the agreement with a questionnaire .",
        "entities": []
    },
    {
        "id": "3938",
        "type": "disease",
        "text": "Immediate allergic reactions to amoxicillin .",
        "entities": [
            "allergic reactions"
        ]
    },
    {
        "id": "2034",
        "type": "disease",
        "text": "Development of proteinuria after switch to sirolimus - based immunosuppression in long - term cardiac transplant patients .",
        "entities": [
            "proteinuria"
        ]
    },
    {
        "id": "3272",
        "type": "disease",
        "text": "The patient recovered .",
        "entities": []
    },
    {
        "id": "317",
        "type": "disease",
        "text": "Surprisingly , the first dose of 50 mg of losartan resulted in a sudden anuria , which lasted eight hours despite high - dose furosemide and amine infusion .",
        "entities": [
            "anuria"
        ]
    },
    {
        "id": "1780",
        "type": "disease",
        "text": "Diffuse intramural vasoconstriction is not consistent with reports of segmental , discrete infarction .",
        "entities": [
            "infarction"
        ]
    },
    {
        "id": "3337",
        "type": "disease",
        "text": "Thirty - four patients with juvenile rheumatoid arthritis , who were treated with flurbiprofen at a maximum dose of 4 mg / kg / day , had statistically significant decreases from baseline in 6 arthritis indices after 12 weeks of treatment .",
        "entities": [
            "juvenile rheumatoid arthritis",
            "arthritis"
        ]
    },
    {
        "id": "507",
        "type": "disease",
        "text": "Subjects supplied information on oral - contraceptive use and major cardiovascular risk factors .",
        "entities": []
    },
    {
        "id": "3983",
        "type": "disease",
        "text": "EBFF did not change during PGE1 infusion whereas in the TMP group , EBF decreased significantly at 30 and 60 min after the start of TMP ( preinfusion : 45 . 9 + / - 13 . 9 ml / 100g / min . 30 min : 32 . 3 + / - 9 . 9 ml / 100 g / min ( P < 0 . 05 ) . 60 min : 30 + / - 7 . 5 ml / 100 g / min ( P < 0 . 05 ) ) .",
        "entities": []
    },
    {
        "id": "2171",
        "type": "disease",
        "text": "Thirty PD patients participated in the study .",
        "entities": [
            "PD"
        ]
    },
    {
        "id": "186",
        "type": "disease",
        "text": "In female rats , only a weak tendency toward aggressiveness was found .",
        "entities": [
            "aggressiveness"
        ]
    },
    {
        "id": "2410",
        "type": "disease",
        "text": "In most patients , discontinuation of sirolimus resulted in a decrease , but not resolution , of proteinuria .",
        "entities": [
            "proteinuria"
        ]
    },
    {
        "id": "1534",
        "type": "disease",
        "text": "CONCLUSION : Complications associated with epidural steroid injections are rare .",
        "entities": []
    },
    {
        "id": "2103",
        "type": "disease",
        "text": "The aim of this study was to delineate brain structures that are involved in NIN generation .",
        "entities": [
            "NIN"
        ]
    },
    {
        "id": "1521",
        "type": "disease",
        "text": "CLINICAL FEATURES : A 50 - year - old woman with low back and right leg pain was scheduled for epidural steroid injection .",
        "entities": [
            "low back and right leg pain"
        ]
    },
    {
        "id": "102",
        "type": "disease",
        "text": "In the current study , we investigated the synergy between these 2 treatments and found that concurrent Warfarin administration dramatically increased the extent of calcification in the media of vitamin D - treated rats at 3 and 4 days .",
        "entities": [
            "calcification"
        ]
    },
    {
        "id": "559",
        "type": "disease",
        "text": "The animal model used to produce infarction implies artery ligation but chemical induction can be easily obtained with isoproterenol .",
        "entities": [
            "infarction"
        ]
    },
    {
        "id": "1631",
        "type": "disease",
        "text": "Severe toxicity was correlated with the higher cumulative dose of 60 g / m2 of ifosfamide , a younger age ( less than 2 1 / 2 years old ) , and a predominance of vesicoprostatic tumor involvement .",
        "entities": [
            "toxicity",
            "tumor"
        ]
    },
    {
        "id": "13",
        "type": "disease",
        "text": "Further studies on the effects of certain irrigating fluids on the rat bladder for 18 hours are reported .",
        "entities": []
    },
    {
        "id": "2385",
        "type": "disease",
        "text": "CONCLUSION : This work shows that confusion with valproic acid is a serious , rather frequent but reversible adverse drug reaction .",
        "entities": [
            "confusion"
        ]
    },
    {
        "id": "143",
        "type": "disease",
        "text": "During activation with Na + , the Vmax remained unchanged , however the K ( Na ) increased by 50 % , indicating a profound decrease in the affinity of the Na + - binding site in NO - deficient rats .",
        "entities": []
    },
    {
        "id": "3237",
        "type": "disease",
        "text": "Close observation of the response status both clinically and with beta - hCG values may indicate whether and when more agressive combination chemotherapy should be started . ( ABSTRACT TRUNCATED AT 250 WORDS )",
        "entities": []
    },
    {
        "id": "3700",
        "type": "disease",
        "text": "Thus , high cimetidine levels alone do not always induce dementia .",
        "entities": [
            "dementia"
        ]
    },
    {
        "id": "3711",
        "type": "disease",
        "text": "Neurologic effects of subarachnoid administration of 2 - chloroprocaine - CE , bupivacaine , and low pH normal saline in dogs .",
        "entities": []
    },
    {
        "id": "3770",
        "type": "disease",
        "text": "In the adriamycin - treated cells , the addition of adenosine increased the adenylate charge and , concomitant with this inrcease , the cells ' functional integrity , in terms of percentage of beating cells and rate of contractions , was maintained .",
        "entities": []
    },
    {
        "id": "2529",
        "type": "disease",
        "text": "The dosing schedule , duration of lithium treatment , and daily dose of lithium did not affect maximum osmolality or creatinine clearance .",
        "entities": []
    },
    {
        "id": "424",
        "type": "disease",
        "text": "2 .",
        "entities": []
    },
    {
        "id": "906",
        "type": "disease",
        "text": "The effect of humoral modulators on the morphine - induced increase in locomotor activity of mice was studied .",
        "entities": [
            "increase in locomotor activity"
        ]
    },
    {
        "id": "451",
        "type": "disease",
        "text": "A 34 - year - old lady developed a constellation of dermatitis , fever , lymphadenopathy and hepatitis , beginning on the 17th day of a course of oral sulphasalazine for sero - negative rheumatoid arthritis .",
        "entities": [
            "dermatitis",
            "fever",
            "lymphadenopathy",
            "hepatitis",
            "rheumatoid arthritis"
        ]
    },
    {
        "id": "3503",
        "type": "disease",
        "text": "Galanthamine hydrobromide , a longer acting anticholinesterase drug , in the treatment of the central effects of scopolamine ( Hyoscine ) .",
        "entities": []
    },
    {
        "id": "591",
        "type": "disease",
        "text": "We conclude that GLEPP1 expression , unlike podocalyxin , reflects podocyte injury induced by PAN .",
        "entities": []
    },
    {
        "id": "684",
        "type": "disease",
        "text": "Various ocular symptoms and findings caused by carboplatin toxicity were seen .",
        "entities": [
            "toxicity"
        ]
    },
    {
        "id": "490",
        "type": "disease",
        "text": "Early trials of cisplatin and amifostine also suggested that the incidence and severity of cisplatin - induced nephrotoxicity , ototoxicity , and neuropathy were reduced .",
        "entities": [
            "nephrotoxicity",
            "ototoxicity",
            "neuropathy"
        ]
    },
    {
        "id": "4253",
        "type": "disease",
        "text": "After the ingestion of 26 venlafaxine 50 - mg tablets , the patient experienced a witnessed generalized seizure .",
        "entities": [
            "seizure"
        ]
    },
    {
        "id": "3275",
        "type": "disease",
        "text": "Assessments of marital happiness and depressed mood were also made using the CES - D and the Azrin Marital Happiness Scale ( AMHS ) .",
        "entities": [
            "depressed mood"
        ]
    },
    {
        "id": "2491",
        "type": "disease",
        "text": "Among them are glycine transporter - 1 ( GlyT1 ) inhibitors such as SSR103800 , which indirectly enhance NMDA receptor function by increasing the glycine ( a co - agonist for the NMDA receptor ) levels in the synapse .",
        "entities": []
    },
    {
        "id": "2024",
        "type": "disease",
        "text": "Our results failed to demonstrate an important response rate to single agent thalidomide in indolent lymphomas and contrast with the higher activity level reported with the second generation immunomodulatory agent , lenalidomide .",
        "entities": [
            "lymphomas"
        ]
    },
    {
        "id": "2281",
        "type": "disease",
        "text": "Alpha - lipoic acid protects sensory neurons through its anti - oxidant and mitochondrial regulatory functions , possibly inducing the expression of frataxin .",
        "entities": []
    },
    {
        "id": "1994",
        "type": "disease",
        "text": "However , combinations of different therapeutic regimens require consideration of potential adverse reactions .",
        "entities": []
    },
    {
        "id": "1910",
        "type": "disease",
        "text": "This study should be repeated on a larger sample .",
        "entities": []
    },
    {
        "id": "3131",
        "type": "disease",
        "text": "Oral administration of CBZ as an aqueous suspension every 8 h at a dose of 250 mg / kg was continuously protective against HFDE - induced seizures and was minimally toxic as measured by weight gain over 8 weeks of treatment .",
        "entities": [
            "seizures",
            "weight gain"
        ]
    },
    {
        "id": "1946",
        "type": "disease",
        "text": "Laryngeal electromyography ( thyroarytenoid muscle ) showed ample denervation potentials .",
        "entities": []
    },
    {
        "id": "2734",
        "type": "disease",
        "text": "BACKGROUND : Current animal models of obsessive - compulsive disorder ( OCD ) typically involve acute , drug - induced symptom provocation or a genetic association with stereotypies or anxiety .",
        "entities": [
            "obsessive - compulsive disorder",
            "OCD",
            "anxiety"
        ]
    },
    {
        "id": "2238",
        "type": "disease",
        "text": "Simvastatinezetimibe and escitalopram ( which she was taking for depression ) were discontinued , and other potential causes of hepatotoxicity were excluded .",
        "entities": [
            "depression",
            "hepatotoxicity"
        ]
    },
    {
        "id": "3021",
        "type": "disease",
        "text": "Five patients receiving fluoxetine for the treatment of obsessive compulsive disorder or major depression developed akathisia .",
        "entities": [
            "obsessive compulsive disorder",
            "major depression",
            "akathisia"
        ]
    },
    {
        "id": "184",
        "type": "disease",
        "text": "The development of apomorphine - induced ( 1 . 0 mg / kg s . c . once daily ) aggressive behavior of adult male and female Wistar rats obtained from the same breeder was studied in two consecutive sets .",
        "entities": [
            "aggressive behavior"
        ]
    },
    {
        "id": "3412",
        "type": "disease",
        "text": "The clinical signs and symptoms , typical laboratory features , and complications of rhabdomyolysis are presented .",
        "entities": [
            "rhabdomyolysis"
        ]
    },
    {
        "id": "489",
        "type": "disease",
        "text": "Amifostine subsequently was shown to protect normal tissues from the toxic effects of alkylating agents and cisplatin without decreasing the antitumor effect of the chemotherapy .",
        "entities": []
    },
    {
        "id": "3520",
        "type": "disease",
        "text": "The first twin , a female , had a left Potter - type IIa polycystic kidney and a rudimentary left uterine cornu .",
        "entities": [
            "Potter - type IIa polycystic kidney",
            "rudimentary left uterine cornu"
        ]
    },
    {
        "id": "985",
        "type": "disease",
        "text": "The aim of the present study was to investigate changes in the plasma calcitonin gene - related peptide ( CGRP ) concentration and platelet serotonin ( 5 - hydroxytriptamine , 5 - HT ) content during the immediate headache and the delayed genuine migraine attack provoked by nitroglycerin .",
        "entities": [
            "headache",
            "migraine"
        ]
    },
    {
        "id": "443",
        "type": "disease",
        "text": "The clinical course and histopathological results of the two cases are presented .",
        "entities": []
    },
    {
        "id": "193",
        "type": "disease",
        "text": "Age at presentation , time of ictus after intoxication , Hunt and Hess grade of subarachnoid hemorrhage , size of the aneurysm , location of the aneurysm , and the Glasgow Outcome Scale score were assessed and compared .",
        "entities": [
            "subarachnoid hemorrhage",
            "aneurysm",
            "aneurysm"
        ]
    },
    {
        "id": "4333",
        "type": "disease",
        "text": "Testosterone was low in less than 50 % of cases with prolactin greater than 35 ng . / ml .",
        "entities": []
    },
    {
        "id": "4545",
        "type": "disease",
        "text": "During culture , no morphological changes were found at effective concentrations of PG - 9 .",
        "entities": []
    },
    {
        "id": "117",
        "type": "disease",
        "text": "However , apomorphine - induced reductions in striatal dopamine turnover were detected in both novel and home cage environments .",
        "entities": []
    },
    {
        "id": "1808",
        "type": "disease",
        "text": "Maltolyl p - coumarate was found to attenuate cognitive deficits in both rat models using passive avoidance test and to reduce apoptotic cell death observed in the hippocampus of the amyloid beta peptide ( 1 - 42 ) - infused rats .",
        "entities": [
            "cognitive deficits"
        ]
    },
    {
        "id": "789",
        "type": "disease",
        "text": "Our patients developed jaundice following treatment with ticlopidine and showed the clinical and laboratory characteristics of cholestatic hepatitis , which resolved after discontinuation of the drug .",
        "entities": [
            "jaundice",
            "cholestatic hepatitis"
        ]
    },
    {
        "id": "3847",
        "type": "disease",
        "text": "This case study reveals an unusual finding of rapidly proliferative crescentic glomerulonephritis in a patient treated with rifampin who had no other identifiable causes for developing this disease .",
        "entities": [
            "glomerulonephritis"
        ]
    },
    {
        "id": "4102",
        "type": "disease",
        "text": "The dose levels incorporate escalating paclitaxel doses , and intrapatient escalations within a given dose level are permitted if toxicity permits .",
        "entities": [
            "toxicity"
        ]
    },
    {
        "id": "1998",
        "type": "disease",
        "text": "Three yr after transplantation she developed renal Fanconi syndrome with severe metabolic acidosis , hypophosphatemia , glycosuria , and aminoaciduria .",
        "entities": [
            "renal Fanconi syndrome",
            "metabolic acidosis",
            "hypophosphatemia",
            "glycosuria",
            "aminoaciduria"
        ]
    },
    {
        "id": "1136",
        "type": "disease",
        "text": "Subjects were asked to aim at the centre of a target , subdivided in concentric circles , from 5 m distance .",
        "entities": []
    },
    {
        "id": "668",
        "type": "disease",
        "text": "Forty - nine percent of patients were pain free 2 h after rizatriptan , compared with 24 . 3 % treated with ergotamine / caffeine ( p < or = 0 . 001 ) , rizatriptan being superior within 1 h of treatment .",
        "entities": [
            "pain"
        ]
    },
    {
        "id": "2730",
        "type": "disease",
        "text": "CONCLUSIONS : PAN glomeruli already showed significant pathology by day 4 , despite relatively mild proteinuria .",
        "entities": [
            "proteinuria"
        ]
    },
    {
        "id": "1801",
        "type": "disease",
        "text": "In patients with diabetes , SCr increases > or = 0 . 5 mg / dL were 5 . 1 % ( 4 of 78 patients ) with iopamidol and 13 . 0 % ( 12 of 92 patients ) with iodixanol ( P = 0 . 11 ) , whereas SCr increases > or = 25 % were 10 . 3 % and 15 . 2 % , respectively ( P = 0 . 37 ) .",
        "entities": [
            "diabetes"
        ]
    },
    {
        "id": "1454",
        "type": "disease",
        "text": "RESULTS : Minutes after oral administration , the patient developed nausea , sweating and hypotension , and finally collapsed .",
        "entities": [
            "nausea",
            "hypotension"
        ]
    },
    {
        "id": "1063",
        "type": "disease",
        "text": "The risk of bladder cancer doubled for every 10 g increment in cyclophosphamide ( OR = 2 . 0 , 95 % confidence interval ( CI ) 0 . 8 to 4 . 9 ) .",
        "entities": [
            "bladder cancer"
        ]
    },
    {
        "id": "1753",
        "type": "disease",
        "text": "Side effects of postoperative administration of methylprednisolone and gentamicin into the posterior sub - Tenon ' s space .",
        "entities": []
    },
    {
        "id": "467",
        "type": "disease",
        "text": "The difference between the bolus and infusion groups in the percentage of participants who saw a 50 % reduction in their headache intensity within 30 minutes was 11 . 8 % ( 95 % CI - 9 . 6 % to 33 . 3 % ) .",
        "entities": [
            "headache"
        ]
    },
    {
        "id": "1691",
        "type": "disease",
        "text": "End - systolic left ventricular posterior wall dimension at the 5 - micrograms / kg per min dobutamine infusion for the doxorubicin - treated group was 14 . 1 + / - 2 . 4 mm versus 19 . 3 + / - 2 . 6 mm for control subjects ( p less than 0 . 01 ) . ( ABSTRACT TRUNCATED AT 250 WORDS )",
        "entities": []
    },
    {
        "id": "350",
        "type": "disease",
        "text": "High doses of this antibiotic combination should be avoided especially in elderly patients .",
        "entities": []
    },
    {
        "id": "2092",
        "type": "disease",
        "text": "[ Nat . Neurosci . 9 ( 2006 ) , 917 ] recently identified the microglial - specific fractalkine receptor ( CX3CR1 ) as an important mediator of MPTP - induced neurodegeneration of DA neurons .",
        "entities": [
            "neurodegeneration"
        ]
    },
    {
        "id": "950",
        "type": "disease",
        "text": "A single 18 . 4 mg / kg ( i . p . ) dose of ( + / - ) - amphetamine hemisulfate , given to rats pretreated with iprindole , resulted in persistent depletion of dopamine in the striatum 1 week later .",
        "entities": []
    },
    {
        "id": "3612",
        "type": "disease",
        "text": "These changes in the serum transaminases were associated with corresponding depletions in the cardiac GOT and GPT .",
        "entities": []
    },
    {
        "id": "2495",
        "type": "disease",
        "text": "Importantly , both classical ( haloperidol ) and atypical ( olanzapine , clozapine and aripiprazole ) antipsychotics were effective in all these models of hyperactivity .",
        "entities": [
            "hyperactivity"
        ]
    },
    {
        "id": "2610",
        "type": "disease",
        "text": "For comparison of sleep architecture variables , 12 healthy comparison participants underwent a single night of experimental polysomnography that followed 1 night of accommodation polysomnography .",
        "entities": []
    },
    {
        "id": "3098",
        "type": "disease",
        "text": "Flestolol is metabolized by plasma esterases and has an elimination half - life of approximately 6 . 5 minutes .",
        "entities": []
    },
    {
        "id": "3881",
        "type": "disease",
        "text": "Gall bladder bile was obtained by ultrasound guided , fine needle puncture from six patients .",
        "entities": []
    },
    {
        "id": "2539",
        "type": "disease",
        "text": "Nitrofurantoins were associated with anophthalmia or microphthalmos ( AOR = 3 . 7 ; 95 % CI , 1 . 1 - 12 . 2 ) , hypoplastic left heart syndrome ( AOR = 4 . 2 ; 95 % CI , 1 . 9 - 9 . 1 ) , atrial septal defects ( AOR = 1 . 9 ; 95 % CI , 1 . 1 - 3 . 4 ) , and cleft lip with cleft palate ( AOR = 2 . 1 ; 95 % CI , 1 . 2 - 3 . 9 ) .",
        "entities": [
            "anophthalmia",
            "microphthalmos",
            "hypoplastic left heart syndrome",
            "atrial septal defects",
            "cleft lip",
            "cleft palate"
        ]
    },
    {
        "id": "4195",
        "type": "disease",
        "text": "All four recovered completely without neurological sequelae following the withdrawal of the offending agents .",
        "entities": [
            "neurological sequelae"
        ]
    },
    {
        "id": "4037",
        "type": "disease",
        "text": "After withdrawal of octreotide in 10 patients without gallstones , 8 patients assessed had return of normal gallbladder contractility within 1 month .",
        "entities": [
            "gallstones"
        ]
    },
    {
        "id": "2447",
        "type": "disease",
        "text": "A brain imaging study and repetitive nerve stimulation test indicated no abnormality .",
        "entities": []
    },
    {
        "id": "680",
        "type": "disease",
        "text": "Generally , carboplatin is said to have milder side effects than cisplatin , whose ocular and orbital toxicity are well known .",
        "entities": [
            "ocular and orbital toxicity"
        ]
    },
    {
        "id": "486",
        "type": "disease",
        "text": "Older reports suggest an objective response rate of 8 % when 60 - 120 mg / m2 of cisplatin is administered every 3 - 4 weeks .",
        "entities": []
    },
    {
        "id": "3683",
        "type": "disease",
        "text": "Characterization of estrogen - induced adenohypophyseal tumors in the Fischer 344 rat .",
        "entities": [
            "adenohypophyseal tumors"
        ]
    },
    {
        "id": "3922",
        "type": "disease",
        "text": "During the first day of hospitalization ( while intubated ) , intravenous metoprolol was given , resulting in severe angioedema .",
        "entities": [
            "angioedema"
        ]
    },
    {
        "id": "3879",
        "type": "disease",
        "text": "Chemical analysis of gall stones retrieved at cholecystectomy from two patients , showed that they contained 71 % and 87 % cholesterol by weight .",
        "entities": [
            "gall stones"
        ]
    },
    {
        "id": "4431",
        "type": "disease",
        "text": "When they do occur they are often unrecognized because of denial but when significant may pose a risk to both the mother and her fetus .",
        "entities": []
    },
    {
        "id": "2784",
        "type": "disease",
        "text": "Twenty patients were asked to quantify the severity of pain after receiving standard lidocaine in one femoral area and buffered lidocaine in the opposite femoral area .",
        "entities": [
            "pain"
        ]
    },
    {
        "id": "3176",
        "type": "disease",
        "text": "By November 1984 the Committee on Safety of Medicines had received 82 reports of possible hepatotoxicity associated with the drug , including five deaths .",
        "entities": [
            "hepatotoxicity",
            "deaths"
        ]
    },
    {
        "id": "2346",
        "type": "disease",
        "text": "Testosterone replacement in castrated DS rats increased BP , renal injury , and upregulation of renal angiotensinogen associated with HS diet .",
        "entities": [
            "renal injury"
        ]
    },
    {
        "id": "583",
        "type": "disease",
        "text": "To better understand the utility of GLEPP1 as a marker of glomerular injury , the amount and distribution of GLEPP1 protein and mRNA were examined by immunohistochemistry , Western blot and RNase protection assay in a model of podocyte injury in the rat .",
        "entities": [
            "glomerular injury"
        ]
    },
    {
        "id": "646",
        "type": "disease",
        "text": "The present study was designed to examine the effect of 5 - HT1B receptor ligands microinjected into the subregions of the nucleus accumbens ( the shell and the core ) on the locomotor hyperactivity induced by cocaine in rats .",
        "entities": [
            "locomotor hyperactivity"
        ]
    },
    {
        "id": "1789",
        "type": "disease",
        "text": "Among the 2000 spots compared for statistical difference , 67 spots were significantly changed in abundance and identified using matrix - assisted laser desorption / ionization time - of - flight MS , atmospheric pressure matrix - assisted laser desorption / ionization and HPLC coupled tandem MS ( LC / MS / MS ) .",
        "entities": []
    },
    {
        "id": "2744",
        "type": "disease",
        "text": "METHODS : Thoracic aorta of male Sprague - Dawley rats was exposed to 0 . 5M CaCl ( 2 ) or normal saline ( NaCl ) .",
        "entities": []
    },
    {
        "id": "4456",
        "type": "disease",
        "text": "Postoperatively , the patient refused DC cardioversion and was treated medically .",
        "entities": []
    },
    {
        "id": "3044",
        "type": "disease",
        "text": "The initiated hepatocytes in the liver were assayed as the gamma - glutamyltransferase ( gamma - GT ) positive foci formed following a 2 - week selection regimen consisting of dietary 0 . 02 % 2 - acetylaminofluorene coupled with a necrogenic dose of CCl4 .",
        "entities": []
    },
    {
        "id": "4049",
        "type": "disease",
        "text": "This is the first reported case of sinus arrest associated with continuous - infusion cimetidine .",
        "entities": [
            "sinus arrest"
        ]
    },
    {
        "id": "99",
        "type": "disease",
        "text": "The second set of experiments examined the possible synergy between vitamin D and Warfarin in artery calcification .",
        "entities": [
            "artery calcification"
        ]
    },
    {
        "id": "3082",
        "type": "disease",
        "text": "In a randomized study , labetalol - induced hypotension and nitroprusside - induced hypotension were compared in 20 patients ( 10 in each group ) scheduled for major orthopedic procedures .",
        "entities": [
            "hypotension",
            "hypotension"
        ]
    },
    {
        "id": "3343",
        "type": "disease",
        "text": "Hyperkalemia has recently been recognized as a complication of nonsteroidal antiinflammatory agents ( NSAID ) such as indomethacin .",
        "entities": [
            "Hyperkalemia"
        ]
    },
    {
        "id": "3254",
        "type": "disease",
        "text": "The delta down , which is the measure of decrease of SBP after a mechanical breath , was 20 . 3 + / - 8 . 4 and 10 . 1 + / - 3 . 8 mm Hg in the HEM and SNP groups , respectively , during hypotension ( P less than 0 . 02 ) .",
        "entities": [
            "HEM",
            "hypotension"
        ]
    },
    {
        "id": "1803",
        "type": "disease",
        "text": "CONCLUSIONS : The rate of contrast - induced nephropathy , defined by multiple end points , is not statistically different after the intraarterial administration of iopamidol or iodixanol to high - risk patients , with or without diabetes mellitus .",
        "entities": [
            "nephropathy",
            "diabetes mellitus"
        ]
    },
    {
        "id": "4310",
        "type": "disease",
        "text": "In view of the potentially widespread use of these compounds , there is an urgent need to develop safer alternatives .",
        "entities": []
    },
    {
        "id": "125",
        "type": "disease",
        "text": "The hemolytic effect of TAM is prevented by low concentrations of alpha - tocopherol ( alpha - T ) and alpha - tocopherol acetate ( alpha - TAc ) ( inactivated functional hydroxyl ) indicating that TAM - induced hemolysis is not related to oxidative membrane damage .",
        "entities": [
            "hemolytic",
            "hemolysis"
        ]
    },
    {
        "id": "3473",
        "type": "disease",
        "text": "Our case supports the hypothesis that endogenous renal prostaglandins play a role in the maintenance of renal blood flow when circulating plasma volume is diminished .",
        "entities": []
    },
    {
        "id": "3147",
        "type": "disease",
        "text": "Resting irCRF levels are suppressed only at the highest corticosterone infusion rate , which resulted in systemic corticosterone levels of 40 micrograms / dl .",
        "entities": []
    },
    {
        "id": "448",
        "type": "disease",
        "text": "We report a favorable response to treatment with citalopram by a 15 - year - old boy with major depression who exhibited palpebral twitching during his first 2 weeks of treatment .",
        "entities": [
            "major depression",
            "palpebral twitching"
        ]
    },
    {
        "id": "3311",
        "type": "disease",
        "text": "In the double blind study with haloperidol , both substances were found to be highly effective in the treatment of psychotic syndromes belonging predominantly to the schizophrenia group .",
        "entities": [
            "psychotic syndromes belonging predominantly to the schizophrenia group"
        ]
    },
    {
        "id": "601",
        "type": "disease",
        "text": "Antinociceptive effect of morphine was reduced in chronically treated rats ( 39 + / - 10 vs . 18 + / - 5 au ) while the combination - induced antinociception was remained similar as an acute treatment ( 298 + / - 7 vs . 280 + / - 17 au ) .",
        "entities": []
    },
    {
        "id": "384",
        "type": "disease",
        "text": "RESULTS : We found PTCR in 14 of 15 cases of TG , in 7 transplant biopsy specimens without TG , and in 13 of 143 native kidney biopsy specimens .",
        "entities": [
            "TG",
            "TG"
        ]
    },
    {
        "id": "1513",
        "type": "disease",
        "text": "Such an effect was , however , reversed in presence of RAMH .",
        "entities": []
    },
    {
        "id": "1066",
        "type": "disease",
        "text": "CONCLUSION : The results indicate a dose - response relationship between cyclophosphamide and the risk of bladder cancer , high cumulative risks in the entire cohort , and also the possibility of risk factors operating even before Wegener ' s granulomatosis .",
        "entities": [
            "bladder cancer",
            "Wegener ' s granulomatosis"
        ]
    },
    {
        "id": "3461",
        "type": "disease",
        "text": "Review of this and previously reported cases indicates the need for early diagnosis of amiodarone pneumonitis , immediate withdrawal of amiodarone , and prompt but continued steroid therapy to ensure full recovery .",
        "entities": [
            "pneumonitis"
        ]
    },
    {
        "id": "2094",
        "type": "disease",
        "text": "Mice in which the CX3CR1 gene has been deleted and replaced with a cDNA encoding enhanced green fluorescent protein ( eGFP ) were treated with METH and examined for striatal neurotoxicity .",
        "entities": [
            "neurotoxicity"
        ]
    },
    {
        "id": "3957",
        "type": "disease",
        "text": "Nitroglycerin has been shown to reduce ST - segment elevation during acute myocardial infarction , an effect potentiated in the dog by agents that reverse nitroglycerin - induced hypotension .",
        "entities": [
            "acute myocardial infarction",
            "hypotension"
        ]
    },
    {
        "id": "2164",
        "type": "disease",
        "text": "CONCLUSION : As fentanyl exacerbated postoperative nausea and vomiting without an improvement in postoperative pain and also had adverse cardiorespiratory effects , it appears to be an unnecessary and possibly detrimental supplement to sevoflurane in day surgery .",
        "entities": [
            "postoperative nausea and vomiting",
            "postoperative pain"
        ]
    },
    {
        "id": "3693",
        "type": "disease",
        "text": "Age and renal clearance of cimetidine .",
        "entities": []
    },
    {
        "id": "3106",
        "type": "disease",
        "text": "In patients with unstable angina , flestolol infusion was found to be safe and effective in controlling chest pain .",
        "entities": [
            "unstable angina",
            "chest pain"
        ]
    },
    {
        "id": "2062",
        "type": "disease",
        "text": "In the present study the role of habituation to the experimental environment on the stimulant effect of nicotine in rats was examined .",
        "entities": []
    },
    {
        "id": "543",
        "type": "disease",
        "text": "In contrast , FS containing aprotinin did not evoke any paroxysmal activity .",
        "entities": []
    },
    {
        "id": "2252",
        "type": "disease",
        "text": "This report demonstrates that not only intravenous , but also oral bisphosphonates can aggravate proteinuria and acute renal failure .",
        "entities": [
            "proteinuria",
            "acute renal failure"
        ]
    },
    {
        "id": "3266",
        "type": "disease",
        "text": "Two patients with signs of carbamazepine neurotoxicity after combined treatment with verapamil showed complete recovery after discontinuation of the calcium entry blocker .",
        "entities": [
            "neurotoxicity"
        ]
    },
    {
        "id": "91",
        "type": "disease",
        "text": "The present studies demonstrate that growth and vitamin D treatment enhance the extent of artery calcification in rats given sufficient doses of Warfarin to inhibit gamma - carboxylation of matrix Gla protein , a calcification inhibitor known to be expressed by smooth muscle cells and macrophages in the artery wall .",
        "entities": [
            "artery calcification",
            "calcification"
        ]
    },
    {
        "id": "161",
        "type": "disease",
        "text": "Given that sympathetic neural dominance exhibits a similar developmental pattern , and given that clonidine induces sympathetic withdrawal and bradycardia , we hypothesized that clonidine ' s developmental effects on cardiac rate and ultrasound production would mirror each other .",
        "entities": [
            "bradycardia"
        ]
    },
    {
        "id": "4033",
        "type": "disease",
        "text": "This article reports the changes in gallbladder function examined by ultrasonography in 20 Chinese patients with active acromegaly treated with sc injection of the somatostatin analog octreotide in dosages of 300 - 1500 micrograms / day for a mean of 24 . 2 + / - 13 . 9 months .",
        "entities": [
            "acromegaly"
        ]
    },
    {
        "id": "2084",
        "type": "disease",
        "text": "Mean peak forced expiratory volume in 1 second ( FEV1 ) increases over baseline and the proportion of patients attaining at least a 15 % increase in the FEV1 ( responders ) were 31 % and 90 % , respectively , for ipratropium and 17 % and 50 % , respectively , for theophylline .",
        "entities": []
    },
    {
        "id": "895",
        "type": "disease",
        "text": "Neuroprotection rendered by MPEP may be associated with the reduction of the methamphetamine - induced dopamine efflux in the striatum due to the blockade of extrastriatal mGluR5 , and with a decrease in hyperthermia .",
        "entities": [
            "hyperthermia"
        ]
    },
    {
        "id": "1854",
        "type": "disease",
        "text": "The latter group was further sub - divided into 13 occult HBV ( HBsAg - negative ) and 7 overt HBV ( HBsAg - positive ) patients .",
        "entities": []
    },
    {
        "id": "3238",
        "type": "disease",
        "text": "Pulmonary shunt and cardiovascular responses to CPAP during nitroprusside - induced hypotension .",
        "entities": [
            "hypotension"
        ]
    },
    {
        "id": "659",
        "type": "disease",
        "text": "In particular , the tendency of cocaine to produce chest pain ought to be in the mind of the emergency nurse when faced with a young victim of chest pain who is otherwise at low risk .",
        "entities": [
            "chest pain",
            "chest pain"
        ]
    },
    {
        "id": "1243",
        "type": "disease",
        "text": "CONCLUSIONS : In the literature , the most - frequent cause of hemolytic uremic syndrome in patients following renal transplantation is recurrence of the hemolytic uremic syndrome .",
        "entities": [
            "hemolytic uremic syndrome",
            "hemolytic uremic syndrome"
        ]
    },
    {
        "id": "81",
        "type": "disease",
        "text": "NRA0160 , 5 - [ 2 - ( 4 - ( 3 - fluorobenzylidene ) piperidin - 1 - yl ) ethyl ] - 4 - ( 4 - fluorophenyl ) thiazole - 2 - carboxamide , has a high affinity for human cloned dopamine D4 . 2 , D4 . 4 and D4 . 7 receptors , with Ki values of 0 . 5 , 0 . 9 and 2 . 7 nM , respectively .",
        "entities": []
    },
    {
        "id": "838",
        "type": "disease",
        "text": "Systolic blood pressure was elevated by an average of 7 mm Hg .",
        "entities": []
    },
    {
        "id": "217",
        "type": "disease",
        "text": "The fits ceased within 4 hours of administering intramuscular pyridoxine , suggesting an aetiology of pyridoxine deficiency secondary to isoniazid medication .",
        "entities": [
            "fits"
        ]
    },
    {
        "id": "733",
        "type": "disease",
        "text": "BACKGROUND : Cardiac troponins I ( cTnI ) and T ( cTnT ) have been shown to be highly sensitive and specific markers of myocardial cell injury .",
        "entities": [
            "myocardial cell injury"
        ]
    },
    {
        "id": "1282",
        "type": "disease",
        "text": "Two separate equimolar doses ( 0 . 2 and 0 . 4 mumol ) of either cocaine or BE were injected ventricularly in unanesthetized juvenile rats .",
        "entities": []
    },
    {
        "id": "4391",
        "type": "disease",
        "text": "Up until now , the only factor studied has been the effect of the diameter of the spinal needle on post - operative sensorineural hearing loss .",
        "entities": [
            "sensorineural hearing loss"
        ]
    },
    {
        "id": "295",
        "type": "disease",
        "text": "In addition to their effects on spasticity , certain adverse cardiorespiratory effects have been reported .",
        "entities": [
            "spasticity"
        ]
    },
    {
        "id": "2241",
        "type": "disease",
        "text": "Her aminotransferase levels returned to normal by postoperative day 23 , and her 2 - year follow - up showed no adverse events .",
        "entities": []
    },
    {
        "id": "4472",
        "type": "disease",
        "text": "In 8 patients the diagnosis of primary pulmonary hypertension was uncertain , 5 of them had taken appetite suppressants .",
        "entities": [
            "primary pulmonary hypertension"
        ]
    },
    {
        "id": "2492",
        "type": "disease",
        "text": "This study aimed at investigating the potential antipsychotic - like properties of SSR103800 , with a particular focus on models of hyperactivity , involving either drug challenge ( ie , amphetamine and MK - 801 ) or transgenic mice ( ie , NMDA Nr1 ( neo - / - ) and DAT ( - / - ) ) .",
        "entities": [
            "hyperactivity"
        ]
    },
    {
        "id": "3655",
        "type": "disease",
        "text": "The present results are consistent with the carcinogenicity experiment suggesting that different mechanisms are involved in FANFT carcinogenesis in the bladder and forestomach , and that aspirin ' s effect on FANFT in the forestomach is not due to an irritant effect associated with increased cell proliferation .",
        "entities": [
            "carcinogenesis"
        ]
    },
    {
        "id": "4115",
        "type": "disease",
        "text": "Seven patients suffering from Parkinson ' s disease ( PD ) with severely disabling dyskinesia received low - dose propranolol as an adjunct to the currently used medical treatment .",
        "entities": [
            "Parkinson ' s disease",
            "PD",
            "dyskinesia"
        ]
    },
    {
        "id": "120",
        "type": "disease",
        "text": "Tamoxifen ( TAM ) , the antiestrogenic drug most widely prescribed in the chemotherapy of breast cancer , induces changes in normal discoid shape of erythrocytes and hemolytic anemia .",
        "entities": [
            "breast cancer",
            "hemolytic anemia"
        ]
    },
    {
        "id": "3436",
        "type": "disease",
        "text": "One patient had focal seizures and transient hemiparesis but recovered completely .",
        "entities": [
            "seizures",
            "transient hemiparesis"
        ]
    },
    {
        "id": "1523",
        "type": "disease",
        "text": "Spread of the contrast medium within the epidural space was determined by radiographic imaging .",
        "entities": []
    },
    {
        "id": "1058",
        "type": "disease",
        "text": "METHODS : In the population based , nationwide Swedish Inpatient Register a cohort of 1065 patients with Wegener ' s granulomatosis , 1969 - 95 , was identified .",
        "entities": [
            "Wegener ' s granulomatosis"
        ]
    },
    {
        "id": "2494",
        "type": "disease",
        "text": "In contrast , SSR103800 failed to affect hyperactivity induced by amphetamine or naturally observed in dopamine transporter ( DAT ( - / - ) ) knockout mice ( 10 - 30 mg / kg p . o . ) .",
        "entities": [
            "hyperactivity"
        ]
    },
    {
        "id": "2781",
        "type": "disease",
        "text": "Reduction in injection pain using buffered lidocaine as a local anesthetic before cardiac catheterization .",
        "entities": [
            "pain"
        ]
    },
    {
        "id": "3986",
        "type": "disease",
        "text": "The appearance of nephrotic syndromes such as proteinuria , hypoalbuminemia , hypercholesterolemia and increase in blood nitrogen urea , induced in rats by injection of puromycin aminonucleoside was markedly inhibited by oral administration of Dup 753 ( losartan ) , a novel angiotensin II receptor antagonist , at a dose of 1 or 2 mg / kg per day .",
        "entities": [
            "nephrotic syndromes",
            "proteinuria",
            "hypoalbuminemia",
            "hypercholesterolemia"
        ]
    },
    {
        "id": "3703",
        "type": "disease",
        "text": "His bundle recordings showed an atrial tachycardia with intermittent exit block and greatly prolonged BH and HV intervals ( 40 and 100 msec , respectively ) .",
        "entities": [
            "atrial tachycardia"
        ]
    },
    {
        "id": "792",
        "type": "disease",
        "text": "The mechanisms of this ticlopidine - induced cholestasis are unclear .",
        "entities": [
            "cholestasis"
        ]
    },
    {
        "id": "4170",
        "type": "disease",
        "text": "Histologic changes were found in rat kidneys after administration of MTX , CY and NG , while no such change was observed after 5 - FU and joint administration of MTX + 5 - FU + CY compared to controls .",
        "entities": []
    },
    {
        "id": "1622",
        "type": "disease",
        "text": "The renal function of 74 children with malignant mesenchymal tumors in complete remission and who have received the same ifosfamide chemotherapy protocol ( International Society of Pediatric Oncology Malignant Mesenchymal Tumor Study 84 [ SIOP MMT 84 ] ) were studied 1 year after the completion of treatment .",
        "entities": [
            "malignant mesenchymal tumors",
            "Malignant Mesenchymal Tumor"
        ]
    },
    {
        "id": "3496",
        "type": "disease",
        "text": "Haematological complications were not troublesome and results of biochemical liver function tests remained normal .",
        "entities": []
    },
    {
        "id": "816",
        "type": "disease",
        "text": "RESULTS : Sub - chronic GVG exposure inhibited the effect of cocaine for 3 days , which exceeded in magnitude and duration the identical acute dose .",
        "entities": []
    },
    {
        "id": "2256",
        "type": "disease",
        "text": "The present study was performed to elucidate the role of SGK1 in the volume retention and fibrosis during nephrotic syndrome .",
        "entities": [
            "volume retention",
            "fibrosis",
            "nephrotic syndrome"
        ]
    },
    {
        "id": "92",
        "type": "disease",
        "text": "The first series of experiments examined the influence of age and growth status on artery calcification in Warfarin - treated rats .",
        "entities": [
            "artery calcification"
        ]
    },
    {
        "id": "1222",
        "type": "disease",
        "text": "Fifty children who were given ceftriaxone were evaluated by serial abdominal sonograms .",
        "entities": []
    },
    {
        "id": "4411",
        "type": "disease",
        "text": "Details of spinal puncture , extension and regression of spinal block , and the times to reach discharge criteria were noted .",
        "entities": []
    },
    {
        "id": "1461",
        "type": "disease",
        "text": "However , increased dyspnoea and bronchospasm necessitated reintubation .",
        "entities": [
            "dyspnoea",
            "bronchospasm"
        ]
    },
    {
        "id": "2380",
        "type": "disease",
        "text": "METHODS : Using the French Pharmacovigilance database , we selected the cases of confusion reported since 1985 with valproic acid .",
        "entities": [
            "confusion"
        ]
    },
    {
        "id": "2437",
        "type": "disease",
        "text": "This pilot trial aimed to evaluate the role of glutamate supplementation for preventing PAC - induced peripheral neuropathy in a randomized , placebo - controlled , double - blinded clinical and electro - diagnostic study .",
        "entities": [
            "peripheral neuropathy"
        ]
    },
    {
        "id": "3010",
        "type": "disease",
        "text": "Source of pain and primitive dysfunction in migraine : an identical site ?",
        "entities": [
            "pain",
            "migraine"
        ]
    },
    {
        "id": "3974",
        "type": "disease",
        "text": "The convulsant activity , the time of latency to convulse and the mortality rate were assessed in each group .",
        "entities": []
    },
    {
        "id": "1002",
        "type": "disease",
        "text": "No side effect was noted during the course of therapy .",
        "entities": []
    },
    {
        "id": "4160",
        "type": "disease",
        "text": "FK506 - associated MAHA is probably rare but physicians must be aware of this severe complication .",
        "entities": [
            "MAHA"
        ]
    },
    {
        "id": "945",
        "type": "disease",
        "text": "In a double blind cross - over study with control group , the patients under timolol treatment presented higher depression values measured through the Beck and the Zung - Conde scales ( p < 0 . 001 vs control ) .",
        "entities": [
            "depression"
        ]
    }
]